@erosolaraijs/cure 1.0.1 → 1.0.2

package/dist/clinician/decisionSupport.js

@@ -0,0 +1,604 @@
+/**
+ * Clinician Decision Support System
+ *
+ * Provides clinical decision support features:
+ * - Treatment recommendations with explanations
+ * - Override management and documentation
+ * - Tumor board integration
+ * - Evidence summaries
+ * - Risk-benefit visualization
+ * - Alert acknowledgment workflows
+ *
+ * Designed to augment (not replace) clinical judgment.
+ */
+import { EventEmitter } from 'events';
+// ═══════════════════════════════════════════════════════════════════════════════
+// DECISION SUPPORT SERVICE
+// ═══════════════════════════════════════════════════════════════════════════════
+export class ClinicalDecisionSupportService extends EventEmitter {
+    recommendations = new Map();
+    overrides = new Map();
+    tumorBoardCases = new Map();
+    alertAcknowledgments = [];
+    constructor() {
+        super();
+    }
+    /**
+     * Generate a clinical recommendation
+     */
+    async generateRecommendation(params) {
+        const id = `REC-${Date.now()}-${Math.random().toString(36).substring(2, 8)}`;
+        const now = new Date();
+        // Generate recommendation based on inputs
+        // In production, this would call the ML prediction service and knowledge base
+        const recommendation = {
+            id,
+            patientId: params.patientId,
+            generatedAt: now,
+            validUntil: new Date(now.getTime() + 7 * 24 * 60 * 60 * 1000), // 7 days
+            primaryRecommendation: this.determinePrimaryRecommendation(params),
+            alternativeOptions: this.determineAlternatives(params),
+            supportingEvidence: this.gatherEvidence(params),
+            biomarkerRationale: this.generateBiomarkerRationale(params.biomarkers, params.genomicAlterations),
+            predictions: this.generatePredictions(params),
+            clinicalConsiderations: this.identifyConsiderations(params),
+            monitoringPlan: this.generateMonitoringPlan(params),
+            clinicalTrialOptions: [],
+            status: 'active'
+        };
+        this.recommendations.set(id, recommendation);
+        this.emit('recommendation-generated', recommendation);
+        return recommendation;
+    }
+    /**
+     * Get recommendation by ID
+     */
+    getRecommendation(recommendationId) {
+        return this.recommendations.get(recommendationId);
+    }
+    /**
+     * Get recommendations for a patient
+     */
+    getPatientRecommendations(patientId) {
+        return Array.from(this.recommendations.values())
+            .filter(r => r.patientId === patientId)
+            .sort((a, b) => b.generatedAt.getTime() - a.generatedAt.getTime());
+    }
+    /**
+     * Accept a recommendation
+     */
+    async acceptRecommendation(recommendationId, clinicianId, clinicianName) {
+        const rec = this.recommendations.get(recommendationId);
+        if (!rec)
+            throw new Error('Recommendation not found');
+        rec.status = 'accepted';
+        rec.reviewedBy = clinicianId;
+        rec.reviewedAt = new Date();
+        this.emit('recommendation-accepted', {
+            recommendationId,
+            clinicianId,
+            clinicianName,
+            recommendation: rec.primaryRecommendation.regimen
+        });
+    }
+    /**
+     * Record an override
+     */
+    async recordOverride(override) {
+        const id = `OVR-${Date.now()}-${Math.random().toString(36).substring(2, 8)}`;
+        const fullOverride = {
+            ...override,
+            id,
+            timestamp: new Date(),
+            auditStatus: this.requiresSupervisorApproval(override) ? 'pending-review' : 'reviewed'
+        };
+        // Check if supervisor approval is required
+        if (this.requiresSupervisorApproval(override)) {
+            fullOverride.supervisorApproval = {
+                required: true
+            };
+        }
+        // Update recommendation status
+        const rec = this.recommendations.get(override.recommendationId);
+        if (rec) {
+            rec.status = override.overrideType === 'full' ? 'rejected' : 'modified';
+            rec.reviewedBy = override.clinicianId;
+            rec.reviewedAt = new Date();
+        }
+        // Store override
+        const patientOverrides = this.overrides.get(override.patientId) || [];
+        patientOverrides.push(fullOverride);
+        this.overrides.set(override.patientId, patientOverrides);
+        this.emit('override-recorded', fullOverride);
+        return id;
+    }
+    /**
+     * Check if supervisor approval is required
+     */
+    requiresSupervisorApproval(override) {
+        // Require approval for certain categories
+        const requiresApproval = [
+            'clinical-judgment',
+            'other'
+        ];
+        if (requiresApproval.includes(override.reason.category))
+            return true;
+        // Require approval if clinician is a trainee
+        if (['resident', 'fellow', 'np-trainee', 'pa-trainee'].some(r => override.clinicianRole.toLowerCase().includes(r))) {
+            return true;
+        }
+        return false;
+    }
+    /**
+     * Approve an override
+     */
+    async approveOverride(overrideId, supervisorId, supervisorName, approved, comments) {
+        for (const [patientId, overrides] of this.overrides) {
+            const override = overrides.find(o => o.id === overrideId);
+            if (override && override.supervisorApproval) {
+                override.supervisorApproval.supervisorId = supervisorId;
+                override.supervisorApproval.supervisorName = supervisorName;
+                override.supervisorApproval.approved = approved;
+                override.supervisorApproval.approvalTimestamp = new Date();
+                override.supervisorApproval.comments = comments;
+                override.auditStatus = approved ? 'reviewed' : 'flagged';
+                this.emit('override-reviewed', { overrideId, approved, supervisorName });
+                return;
+            }
+        }
+        throw new Error('Override not found');
+    }
+    /**
+     * Get overrides for a patient
+     */
+    getPatientOverrides(patientId) {
+        return this.overrides.get(patientId) || [];
+    }
+    /**
+     * Get pending approvals for a supervisor
+     */
+    getPendingApprovals() {
+        const pending = [];
+        for (const overrides of this.overrides.values()) {
+            for (const override of overrides) {
+                if (override.supervisorApproval?.required && !override.supervisorApproval.approved) {
+                    pending.push(override);
+                }
+            }
+        }
+        return pending.sort((a, b) => b.timestamp.getTime() - a.timestamp.getTime());
+    }
+    /**
+     * Create a tumor board case
+     */
+    async createTumorBoardCase(caseData) {
+        const id = `TB-${Date.now()}-${Math.random().toString(36).substring(2, 8)}`;
+        const tumorBoardCase = {
+            ...caseData,
+            id,
+            status: 'scheduled',
+            actions: []
+        };
+        // Attach active recommendation if available
+        const recommendations = this.getPatientRecommendations(caseData.patientId);
+        if (recommendations.length > 0 && recommendations[0].status === 'active') {
+            tumorBoardCase.systemRecommendation = recommendations[0];
+        }
+        this.tumorBoardCases.set(id, tumorBoardCase);
+        this.emit('tumor-board-case-created', { caseId: id, patientId: caseData.patientId });
+        return id;
+    }
+    /**
+     * Record tumor board decision
+     */
+    async recordTumorBoardDecision(caseId, decision) {
+        const tbCase = this.tumorBoardCases.get(caseId);
+        if (!tbCase)
+            throw new Error('Tumor board case not found');
+        tbCase.boardDecision = decision;
+        tbCase.status = 'completed';
+        this.emit('tumor-board-decision-recorded', { caseId, decision });
+    }
+    /**
+     * Acknowledge an alert
+     */
+    async acknowledgeAlert(acknowledgment) {
+        const fullAcknowledgment = {
+            ...acknowledgment,
+            acknowledgedAt: new Date()
+        };
+        this.alertAcknowledgments.push(fullAcknowledgment);
+        this.emit('alert-acknowledged', fullAcknowledgment);
+    }
+    /**
+     * Generate explanation for a recommendation
+     */
+    generateExplanation(recommendation) {
+        const summary = `Based on the patient's ${recommendation.biomarkerRationale.map(b => b.biomarker).join(', ')} status, ` +
+            `${recommendation.primaryRecommendation.regimen} is recommended with ` +
+            `${(recommendation.predictions.responseRate.value * 100).toFixed(0)}% expected response rate.`;
+        const detailedRationale = [];
+        // Add biomarker rationale
+        for (const br of recommendation.biomarkerRationale) {
+            detailedRationale.push(`${br.biomarker} ${br.status}: ${br.impact}`);
+        }
+        // Add evidence rationale
+        for (const ev of recommendation.supportingEvidence.filter(e => e.strength === 'strong')) {
+            detailedRationale.push(`${ev.source}: ${ev.description}`);
+        }
+        // Key factors
+        const keyFactors = recommendation.biomarkerRationale.map(br => ({
+            factor: `${br.biomarker} ${br.status}`,
+            impact: this.determineImpact(br.impact),
+            weight: this.determineWeight(br.evidenceLevel)
+        }));
+        // Uncertainties
+        const uncertainties = [];
+        if (recommendation.predictions.responseRate.ci95[1] - recommendation.predictions.responseRate.ci95[0] > 0.3) {
+            uncertainties.push('Response rate prediction has wide confidence interval');
+        }
+        if (recommendation.supportingEvidence.every(e => e.strength !== 'strong')) {
+            uncertainties.push('Limited strong evidence available for this combination');
+        }
+        // Alternative considerations
+        const alternativeConsiderations = recommendation.alternativeOptions.map(alt => `${alt.regimen}: ${alt.comparisonToPrimary}`);
+        return {
+            summary,
+            detailedRationale,
+            keyFactors,
+            uncertainties,
+            alternativeConsiderations
+        };
+    }
+    /**
+     * Generate risk-benefit analysis
+     */
+    generateRiskBenefitAnalysis(recommendation) {
+        const benefits = [
+            {
+                benefit: `${(recommendation.predictions.responseRate.value * 100).toFixed(0)}% objective response rate`,
+                magnitude: recommendation.predictions.responseRate.value > 0.5 ? 'high' :
+                    recommendation.predictions.responseRate.value > 0.3 ? 'moderate' : 'low',
+                confidence: recommendation.primaryRecommendation.confidenceScore
+            },
+            {
+                benefit: `Median PFS ${recommendation.predictions.medianPFS.value.toFixed(1)} months`,
+                magnitude: recommendation.predictions.medianPFS.value > 12 ? 'high' :
+                    recommendation.predictions.medianPFS.value > 6 ? 'moderate' : 'low',
+                confidence: recommendation.primaryRecommendation.confidenceScore
+            }
+        ];
+        const risks = recommendation.predictions.grade3PlusToxicity.topRisks.map((risk, i) => ({
+            risk,
+            probability: recommendation.predictions.grade3PlusToxicity.value * (1 - i * 0.1),
+            severity: 'moderate',
+            manageable: true
+        }));
+        // Calculate NNT (simplified)
+        const baselineResponse = 0.2; // Assumed baseline
+        const treatmentResponse = recommendation.predictions.responseRate.value;
+        const absoluteBenefit = treatmentResponse - baselineResponse;
+        const numberNeededToTreat = absoluteBenefit > 0 ? Math.ceil(1 / absoluteBenefit) : undefined;
+        // Calculate NNH (simplified)
+        const toxicityRate = recommendation.predictions.grade3PlusToxicity.value;
+        const baselineToxicity = 0.1;
+        const absoluteHarm = toxicityRate - baselineToxicity;
+        const numberNeededToHarm = absoluteHarm > 0 ? Math.ceil(1 / absoluteHarm) : undefined;
+        const overallAssessment = this.generateOverallAssessment(benefits, risks, numberNeededToTreat, numberNeededToHarm);
+        return {
+            benefits,
+            risks,
+            overallAssessment,
+            numberNeededToTreat,
+            numberNeededToHarm
+        };
+    }
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // HELPER METHODS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    determinePrimaryRecommendation(params) {
+        // Simplified logic - would use ML service in production
+        let regimen = 'Standard therapy';
+        let drugs = [];
+        let confidenceScore = 0.75;
+        // Check for biomarker-matched therapy
+        const alterations = params.genomicAlterations || [];
+        // EGFR mutation
+        if (alterations.some((a) => a.gene === 'EGFR')) {
+            regimen = 'Osimertinib';
+            drugs = [{
+                    name: 'Osimertinib',
+                    dose: '80mg',
+                    schedule: 'Daily',
+                    route: 'Oral'
+                }];
+            confidenceScore = 0.92;
+        }
+        // ALK fusion
+        else if (alterations.some((a) => a.gene === 'ALK')) {
+            regimen = 'Alectinib';
+            drugs = [{
+                    name: 'Alectinib',
+                    dose: '600mg',
+                    schedule: 'BID',
+                    route: 'Oral'
+                }];
+            confidenceScore = 0.90;
+        }
+        // PD-L1 high
+        else if (params.biomarkers.some((b) => b.name.toLowerCase().includes('pd-l1') && parseFloat(b.value) >= 50)) {
+            regimen = 'Pembrolizumab';
+            drugs = [{
+                    name: 'Pembrolizumab',
+                    dose: '200mg',
+                    schedule: 'Q3W',
+                    route: 'IV'
+                }];
+            confidenceScore = 0.85;
+        }
+        // Default chemotherapy
+        else {
+            regimen = 'Carboplatin + Pemetrexed + Pembrolizumab';
+            drugs = [
+                { name: 'Carboplatin', dose: 'AUC 5', schedule: 'Q3W', route: 'IV' },
+                { name: 'Pemetrexed', dose: '500mg/m²', schedule: 'Q3W', route: 'IV' },
+                { name: 'Pembrolizumab', dose: '200mg', schedule: 'Q3W', route: 'IV' }
+            ];
+            confidenceScore = 0.78;
+        }
+        return {
+            regimen,
+            drugs,
+            setting: params.priorTherapies?.length > 0 ? 'second-line' : 'first-line',
+            confidenceScore
+        };
+    }
+    determineAlternatives(params) {
+        // Generate 2-3 alternative options
+        return [
+            {
+                regimen: 'Clinical trial',
+                drugs: ['Investigational agent'],
+                confidenceScore: 0.7,
+                comparisonToPrimary: 'Access to novel therapies; additional monitoring required'
+            },
+            {
+                regimen: 'Alternative standard therapy',
+                drugs: ['Docetaxel'],
+                confidenceScore: 0.65,
+                comparisonToPrimary: 'Lower efficacy but familiar toxicity profile'
+            }
+        ];
+    }
+    gatherEvidence(params) {
+        const evidence = [];
+        // Add guideline evidence
+        evidence.push({
+            type: 'guideline',
+            source: 'NCCN Guidelines',
+            description: `Recommended for ${params.cancerType} stage ${params.stage}`,
+            strength: 'strong',
+            url: 'https://www.nccn.org/guidelines'
+        });
+        // Add clinical trial evidence based on biomarkers
+        if (params.genomicAlterations?.some((a) => a.gene === 'EGFR')) {
+            evidence.push({
+                type: 'clinical-trial',
+                source: 'FLAURA trial',
+                description: 'Osimertinib improved median PFS vs 1st-gen TKI (18.9 vs 10.2 months)',
+                strength: 'strong'
+            });
+        }
+        if (params.biomarkers?.some((b) => b.name.toLowerCase().includes('pd-l1') && parseFloat(b.value) >= 50)) {
+            evidence.push({
+                type: 'clinical-trial',
+                source: 'KEYNOTE-024',
+                description: 'Pembrolizumab improved OS vs chemotherapy in PD-L1 ≥50%',
+                strength: 'strong'
+            });
+        }
+        return evidence;
+    }
+    generateBiomarkerRationale(biomarkers, alterations) {
+        const rationale = [];
+        for (const alt of alterations) {
+            rationale.push({
+                biomarker: alt.gene,
+                status: alt.alteration,
+                impact: this.getBiomarkerImpact(alt.gene, alt.alteration),
+                evidenceLevel: this.getBiomarkerEvidenceLevel(alt.gene)
+            });
+        }
+        for (const bm of biomarkers) {
+            if (!rationale.some(r => r.biomarker === bm.name)) {
+                rationale.push({
+                    biomarker: bm.name,
+                    status: String(bm.value),
+                    impact: this.getBiomarkerImpact(bm.name, String(bm.value)),
+                    evidenceLevel: this.getBiomarkerEvidenceLevel(bm.name)
+                });
+            }
+        }
+        return rationale;
+    }
+    getBiomarkerImpact(biomarker, value) {
+        const impacts = {
+            'EGFR': 'Sensitive to EGFR TKI therapy',
+            'ALK': 'Sensitive to ALK TKI therapy',
+            'BRAF': 'Sensitive to BRAF/MEK inhibitor combination',
+            'KRAS G12C': 'Sensitive to KRAS G12C inhibitors',
+            'PD-L1': parseFloat(value) >= 50 ? 'High likelihood of response to immunotherapy' :
+                parseFloat(value) >= 1 ? 'May benefit from immunotherapy' :
+                    'Consider immunotherapy combination',
+            'MSI-H': 'High likelihood of response to immunotherapy',
+            'TMB': 'May predict immunotherapy response'
+        };
+        return impacts[biomarker] || 'Prognostic significance';
+    }
+    getBiomarkerEvidenceLevel(biomarker) {
+        const fdaApproved = ['EGFR', 'ALK', 'ROS1', 'BRAF', 'NTRK', 'RET', 'MET', 'KRAS G12C', 'HER2'];
+        if (fdaApproved.includes(biomarker))
+            return 'FDA-approved';
+        const nccnRecommended = ['PD-L1', 'MSI-H', 'TMB'];
+        if (nccnRecommended.includes(biomarker))
+            return 'NCCN-recommended';
+        return 'Clinical evidence';
+    }
+    generatePredictions(params) {
+        // Simplified predictions - would use ML service in production
+        let responseRate = 0.4;
+        let pfs = 8;
+        let os = 18;
+        let toxicityRisk = 0.25;
+        // Adjust based on biomarkers
+        if (params.genomicAlterations?.some((a) => ['EGFR', 'ALK', 'ROS1'].includes(a.gene))) {
+            responseRate = 0.75;
+            pfs = 15;
+            os = 30;
+            toxicityRisk = 0.15;
+        }
+        // Adjust based on PD-L1
+        const pdl1 = params.biomarkers?.find((b) => b.name.toLowerCase().includes('pd-l1'));
+        if (pdl1 && parseFloat(pdl1.value) >= 50) {
+            responseRate = Math.max(responseRate, 0.45);
+        }
+        // Adjust based on performance status
+        if (params.performanceStatus && params.performanceStatus >= 2) {
+            responseRate *= 0.8;
+            pfs *= 0.7;
+            os *= 0.7;
+            toxicityRisk *= 1.3;
+        }
+        return {
+            responseRate: {
+                value: responseRate,
+                ci95: [responseRate * 0.8, Math.min(responseRate * 1.2, 0.95)]
+            },
+            medianPFS: {
+                value: pfs,
+                ci95: [pfs * 0.75, pfs * 1.3],
+                unit: 'months'
+            },
+            medianOS: {
+                value: os,
+                ci95: [os * 0.7, os * 1.4],
+                unit: 'months'
+            },
+            grade3PlusToxicity: {
+                value: toxicityRisk,
+                topRisks: ['Neutropenia', 'Fatigue', 'Nausea']
+            },
+            qualityOfLife: {
+                score: 0.75,
+                considerations: ['Oral therapy allows home administration', 'Weekly monitoring during first cycle']
+            }
+        };
+    }
+    identifyConsiderations(params) {
+        const considerations = [];
+        // Performance status
+        if (params.performanceStatus && params.performanceStatus >= 2) {
+            considerations.push({
+                category: 'safety',
+                consideration: 'Consider dose reduction due to performance status',
+                importance: 'critical'
+            });
+        }
+        // Prior therapy
+        if (params.priorTherapies && params.priorTherapies.length > 2) {
+            considerations.push({
+                category: 'efficacy',
+                consideration: 'Heavily pretreated patient - consider clinical trial',
+                importance: 'important'
+            });
+        }
+        // Comorbidities
+        if (params.comorbidities?.some((c) => c.toLowerCase().includes('renal'))) {
+            considerations.push({
+                category: 'safety',
+                consideration: 'Dose adjustment may be needed for renal impairment',
+                importance: 'critical'
+            });
+        }
+        return considerations;
+    }
+    generateMonitoringPlan(params) {
+        return [
+            { item: 'CBC with differential', frequency: 'Before each cycle', rationale: 'Monitor for myelosuppression' },
+            { item: 'Comprehensive metabolic panel', frequency: 'Before each cycle', rationale: 'Monitor liver/kidney function' },
+            { item: 'Imaging (CT chest/abdomen)', frequency: 'Every 8-12 weeks', rationale: 'Response assessment (RECIST)' },
+            { item: 'Clinical assessment', frequency: 'Each visit', rationale: 'Monitor for adverse events' }
+        ];
+    }
+    determineImpact(impactText) {
+        if (impactText.toLowerCase().includes('sensitive') ||
+            impactText.toLowerCase().includes('response') ||
+            impactText.toLowerCase().includes('benefit')) {
+            return 'positive';
+        }
+        if (impactText.toLowerCase().includes('resistant') ||
+            impactText.toLowerCase().includes('poor')) {
+            return 'negative';
+        }
+        return 'neutral';
+    }
+    determineWeight(evidenceLevel) {
+        const weights = {
+            'FDA-approved': 1.0,
+            'NCCN-recommended': 0.9,
+            'Clinical evidence': 0.7,
+            'Preclinical': 0.3
+        };
+        return weights[evidenceLevel] || 0.5;
+    }
+    generateOverallAssessment(benefits, risks, nnt, nnh) {
+        const highBenefits = benefits.filter(b => b.magnitude === 'high').length;
+        const severeRisks = risks.filter(r => r.severity === 'severe' && r.probability > 0.1).length;
+        if (highBenefits >= 2 && severeRisks === 0) {
+            return 'Favorable risk-benefit profile. Treatment strongly recommended.';
+        }
+        if (highBenefits >= 1 && severeRisks <= 1) {
+            return 'Acceptable risk-benefit profile. Treatment recommended with appropriate monitoring.';
+        }
+        if (severeRisks >= 2) {
+            return 'Elevated risk profile. Consider alternatives or enhanced monitoring if proceeding.';
+        }
+        return 'Moderate risk-benefit profile. Individual patient factors should guide decision.';
+    }
+    /**
+     * Export decision data for quality review
+     */
+    exportDecisionData(startDate, endDate) {
+        const recommendations = Array.from(this.recommendations.values())
+            .filter(r => r.generatedAt >= startDate && r.generatedAt <= endDate);
+        const allOverrides = Array.from(this.overrides.values()).flat()
+            .filter(o => o.timestamp >= startDate && o.timestamp <= endDate);
+        const cases = Array.from(this.tumorBoardCases.values())
+            .filter(c => c.scheduledDate >= startDate && c.scheduledDate <= endDate);
+        // Calculate summary statistics
+        const accepted = recommendations.filter(r => r.status === 'accepted').length;
+        const overridden = recommendations.filter(r => r.status === 'modified' || r.status === 'rejected').length;
+        // Count override reasons
+        const reasonCounts = new Map();
+        for (const override of allOverrides) {
+            const count = reasonCounts.get(override.reason.category) || 0;
+            reasonCounts.set(override.reason.category, count + 1);
+        }
+        const commonOverrideReasons = Array.from(reasonCounts.entries())
+            .map(([reason, count]) => ({ reason, count }))
+            .sort((a, b) => b.count - a.count);
+        return {
+            recommendations,
+            overrides: allOverrides,
+            tumorBoardCases: cases,
+            summary: {
+                totalRecommendations: recommendations.length,
+                acceptanceRate: recommendations.length > 0 ? accepted / recommendations.length : 0,
+                overrideRate: recommendations.length > 0 ? overridden / recommendations.length : 0,
+                commonOverrideReasons
+            }
+        };
+    }
+}
+export default ClinicalDecisionSupportService;
+//# sourceMappingURL=decisionSupport.js.map

package/dist/clinician/decisionSupport.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"decisionSupport.js","sourceRoot":"","sources":["../../src/clinician/decisionSupport.ts"],"names":[],"mappings":"AAAA;;;;;;;;;;;;GAYG;AAEH,OAAO,EAAE,YAAY,EAAE,MAAM,QAAQ,CAAC;AAiMtC,kFAAkF;AAClF,2BAA2B;AAC3B,kFAAkF;AAElF,MAAM,OAAO,8BAA+B,SAAQ,YAAY;IACtD,eAAe,GAAwC,IAAI,GAAG,EAAE,CAAC;IACjE,SAAS,GAAqC,IAAI,GAAG,EAAE,CAAC;IACxD,eAAe,GAAgC,IAAI,GAAG,EAAE,CAAC;IACzD,oBAAoB,GAA0B,EAAE,CAAC;IAEzD;QACE,KAAK,EAAE,CAAC;IACV,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,sBAAsB,CAAC,MAU5B;QACC,MAAM,EAAE,GAAG,OAAO,IAAI,CAAC,GAAG,EAAE,IAAI,IAAI,CAAC,MAAM,EAAE,CAAC,QAAQ,CAAC,EAAE,CAAC,CAAC,SAAS,CAAC,CAAC,EAAE,CAAC,CAAC,EAAE,CAAC;QAC7E,MAAM,GAAG,GAAG,IAAI,IAAI,EAAE,CAAC;QAEvB,0CAA0C;QAC1C,8EAA8E;QAC9E,MAAM,cAAc,GAA2B;YAC7C,EAAE;YACF,SAAS,EAAE,MAAM,CAAC,SAAS;YAC3B,WAAW,EAAE,GAAG;YAChB,UAAU,EAAE,IAAI,IAAI,CAAC,GAAG,CAAC,OAAO,EAAE,GAAG,CAAC,GAAG,EAAE,GAAG,EAAE,GAAG,EAAE,GAAG,IAAI,CAAC,EAAE,SAAS;YAExE,qBAAqB,EAAE,IAAI,CAAC,8BAA8B,CAAC,MAAM,CAAC;YAClE,kBAAkB,EAAE,IAAI,CAAC,qBAAqB,CAAC,MAAM,CAAC;YACtD,kBAAkB,EAAE,IAAI,CAAC,cAAc,CAAC,MAAM,CAAC;YAC/C,kBAAkB,EAAE,IAAI,CAAC,0BAA0B,CAAC,MAAM,CAAC,UAAU,EAAE,MAAM,CAAC,kBAAkB,CAAC;YACjG,WAAW,EAAE,IAAI,CAAC,mBAAmB,CAAC,MAAM,CAAC;YAC7C,sBAAsB,EAAE,IAAI,CAAC,sBAAsB,CAAC,MAAM,CAAC;YAC3D,cAAc,EAAE,IAAI,CAAC,sBAAsB,CAAC,MAAM,CAAC;YACnD,oBAAoB,EAAE,EAAE;YACxB,MAAM,EAAE,QAAQ;SACjB,CAAC;QAEF,IAAI,CAAC,eAAe,CAAC,GAAG,CAAC,EAAE,EAAE,cAAc,CAAC,CAAC;QAC7C,IAAI,CAAC,IAAI,CAAC,0BAA0B,EAAE,cAAc,CAAC,CAAC;QAEtD,OAAO,cAAc,CAAC;IACxB,CAAC;IAED;;OAEG;IACH,iBAAiB,CAAC,gBAAwB;QACxC,OAAO,IAAI,CAAC,eAAe,CAAC,GAAG,CAAC,gBAAgB,CAAC,CAAC;IACpD,CAAC;IAED;;OAEG;IACH,yBAAyB,CAAC,SAAiB;QACzC,OAAO,KAAK,CAAC,IAAI,CAAC,IAAI,CAAC,eAAe,CAAC,MAAM,EAAE,CAAC;aAC7C,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,SAAS,KAAK,SAAS,CAAC;aACtC,IAAI,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,WAAW,CAAC,OAAO,EAAE,GAAG,CAAC,CAAC,WAAW,CAAC,OAAO,EAAE,CAAC,CAAC;IACvE,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,oBAAoB,CACxB,gBAAwB,EACxB,WAAmB,EACnB,aAAqB;QAErB,MAAM,GAAG,GAAG,IAAI,CAAC,eAAe,CAAC,GAAG,CAAC,gBAAgB,CAAC,CAAC;QACvD,IAAI,CAAC,GAAG;YAAE,MAAM,IAAI,KAAK,CAAC,0BAA0B,CAAC,CAAC;QAEtD,GAAG,CAAC,MAAM,GAAG,UAAU,CAAC;QACxB,GAAG,CAAC,UAAU,GAAG,WAAW,CAAC;QAC7B,GAAG,CAAC,UAAU,GAAG,IAAI,IAAI,EAAE,CAAC;QAE5B,IAAI,CAAC,IAAI,CAAC,yBAAyB,EAAE;YACnC,gBAAgB;YAChB,WAAW;YACX,aAAa;YACb,cAAc,EAAE,GAAG,CAAC,qBAAqB,CAAC,OAAO;SAClD,CAAC,CAAC;IACL,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,cAAc,CAAC,QAAqE;QACxF,MAAM,EAAE,GAAG,OAAO,IAAI,CAAC,GAAG,EAAE,IAAI,IAAI,CAAC,MAAM,EAAE,CAAC,QAAQ,CAAC,EAAE,CAAC,CAAC,SAAS,CAAC,CAAC,EAAE,CAAC,CAAC,EAAE,CAAC;QAE7E,MAAM,YAAY,GAAsB;YACtC,GAAG,QAAQ;YACX,EAAE;YACF,SAAS,EAAE,IAAI,IAAI,EAAE;YACrB,WAAW,EAAE,IAAI,CAAC,0BAA0B,CAAC,QAAQ,CAAC,CAAC,CAAC,CAAC,gBAAgB,CAAC,CAAC,CAAC,UAAU;SACvF,CAAC;QAEF,2CAA2C;QAC3C,IAAI,IAAI,CAAC,0BAA0B,CAAC,QAAQ,CAAC,EAAE,CAAC;YAC9C,YAAY,CAAC,kBAAkB,GAAG;gBAChC,QAAQ,EAAE,IAAI;aACf,CAAC;QACJ,CAAC;QAED,+BAA+B;QAC/B,MAAM,GAAG,GAAG,IAAI,CAAC,eAAe,CAAC,GAAG,CAAC,QAAQ,CAAC,gBAAgB,CAAC,CAAC;QAChE,IAAI,GAAG,EAAE,CAAC;YACR,GAAG,CAAC,MAAM,GAAG,QAAQ,CAAC,YAAY,KAAK,MAAM,CAAC,CAAC,CAAC,UAAU,CAAC,CAAC,CAAC,UAAU,CAAC;YACxE,GAAG,CAAC,UAAU,GAAG,QAAQ,CAAC,WAAW,CAAC;YACtC,GAAG,CAAC,UAAU,GAAG,IAAI,IAAI,EAAE,CAAC;QAC9B,CAAC;QAED,iBAAiB;QACjB,MAAM,gBAAgB,GAAG,IAAI,CAAC,SAAS,CAAC,GAAG,CAAC,QAAQ,CAAC,SAAS,CAAC,IAAI,EAAE,CAAC;QACtE,gBAAgB,CAAC,IAAI,CAAC,YAAY,CAAC,CAAC;QACpC,IAAI,CAAC,SAAS,CAAC,GAAG,CAAC,QAAQ,CAAC,SAAS,EAAE,gBAAgB,CAAC,CAAC;QAEzD,IAAI,CAAC,IAAI,CAAC,mBAAmB,EAAE,YAAY,CAAC,CAAC;QAE7C,OAAO,EAAE,CAAC;IACZ,CAAC;IAED;;OAEG;IACK,0BAA0B,CAAC,QAAqE;QACtG,0CAA0C;QAC1C,MAAM,gBAAgB,GAAG;YACvB,mBAAmB;YACnB,OAAO;SACR,CAAC;QAEF,IAAI,gBAAgB,CAAC,QAAQ,CAAC,QAAQ,CAAC,MAAM,CAAC,QAAQ,CAAC;YAAE,OAAO,IAAI,CAAC;QAErE,6CAA6C;QAC7C,IAAI,CAAC,UAAU,EAAE,QAAQ,EAAE,YAAY,EAAE,YAAY,CAAC,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,CAC9D,QAAQ,CAAC,aAAa,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,CAAC,CAAC,CACjD,EAAE,CAAC;YACF,OAAO,IAAI,CAAC;QACd,CAAC;QAED,OAAO,KAAK,CAAC;IACf,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,eAAe,CACnB,UAAkB,EAClB,YAAoB,EACpB,cAAsB,EACtB,QAAiB,EACjB,QAAiB;QAEjB,KAAK,MAAM,CAAC,SAAS,EAAE,SAAS,CAAC,IAAI,IAAI,CAAC,SAAS,EAAE,CAAC;YACpD,MAAM,QAAQ,GAAG,SAAS,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,EAAE,KAAK,UAAU,CAAC,CAAC;YAC1D,IAAI,QAAQ,IAAI,QAAQ,CAAC,kBAAkB,EAAE,CAAC;gBAC5C,QAAQ,CAAC,kBAAkB,CAAC,YAAY,GAAG,YAAY,CAAC;gBACxD,QAAQ,CAAC,kBAAkB,CAAC,cAAc,GAAG,cAAc,CAAC;gBAC5D,QAAQ,CAAC,kBAAkB,CAAC,QAAQ,GAAG,QAAQ,CAAC;gBAChD,QAAQ,CAAC,kBAAkB,CAAC,iBAAiB,GAAG,IAAI,IAAI,EAAE,CAAC;gBAC3D,QAAQ,CAAC,kBAAkB,CAAC,QAAQ,GAAG,QAAQ,CAAC;gBAChD,QAAQ,CAAC,WAAW,GAAG,QAAQ,CAAC,CAAC,CAAC,UAAU,CAAC,CAAC,CAAC,SAAS,CAAC;gBAEzD,IAAI,CAAC,IAAI,CAAC,mBAAmB,EAAE,EAAE,UAAU,EAAE,QAAQ,EAAE,cAAc,EAAE,CAAC,CAAC;gBACzE,OAAO;YACT,CAAC;QACH,CAAC;QAED,MAAM,IAAI,KAAK,CAAC,oBAAoB,CAAC,CAAC;IACxC,CAAC;IAED;;OAEG;IACH,mBAAmB,CAAC,SAAiB;QACnC,OAAO,IAAI,CAAC,SAAS,CAAC,GAAG,CAAC,SAAS,CAAC,IAAI,EAAE,CAAC;IAC7C,CAAC;IAED;;OAEG;IACH,mBAAmB;QACjB,MAAM,OAAO,GAAwB,EAAE,CAAC;QAExC,KAAK,MAAM,SAAS,IAAI,IAAI,CAAC,SAAS,CAAC,MAAM,EAAE,EAAE,CAAC;YAChD,KAAK,MAAM,QAAQ,IAAI,SAAS,EAAE,CAAC;gBACjC,IAAI,QAAQ,CAAC,kBAAkB,EAAE,QAAQ,IAAI,CAAC,QAAQ,CAAC,kBAAkB,CAAC,QAAQ,EAAE,CAAC;oBACnF,OAAO,CAAC,IAAI,CAAC,QAAQ,CAAC,CAAC;gBACzB,CAAC;YACH,CAAC;QACH,CAAC;QAED,OAAO,OAAO,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,SAAS,CAAC,OAAO,EAAE,GAAG,CAAC,CAAC,SAAS,CAAC,OAAO,EAAE,CAAC,CAAC;IAC/E,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,oBAAoB,CAAC,QAA6E;QACtG,MAAM,EAAE,GAAG,MAAM,IAAI,CAAC,GAAG,EAAE,IAAI,IAAI,CAAC,MAAM,EAAE,CAAC,QAAQ,CAAC,EAAE,CAAC,CAAC,SAAS,CAAC,CAAC,EAAE,CAAC,CAAC,EAAE,CAAC;QAE5E,MAAM,cAAc,GAAmB;YACrC,GAAG,QAAQ;YACX,EAAE;YACF,MAAM,EAAE,WAAW;YACnB,OAAO,EAAE,EAAE;SACZ,CAAC;QAEF,4CAA4C;QAC5C,MAAM,eAAe,GAAG,IAAI,CAAC,yBAAyB,CAAC,QAAQ,CAAC,SAAS,CAAC,CAAC;QAC3E,IAAI,eAAe,CAAC,MAAM,GAAG,CAAC,IAAI,eAAe,CAAC,CAAC,CAAC,CAAC,MAAM,KAAK,QAAQ,EAAE,CAAC;YACzE,cAAc,CAAC,oBAAoB,GAAG,eAAe,CAAC,CAAC,CAAC,CAAC;QAC3D,CAAC;QAED,IAAI,CAAC,eAAe,CAAC,GAAG,CAAC,EAAE,EAAE,cAAc,CAAC,CAAC;QAC7C,IAAI,CAAC,IAAI,CAAC,0BAA0B,EAAE,EAAE,MAAM,EAAE,EAAE,EAAE,SAAS,EAAE,QAAQ,CAAC,SAAS,EAAE,CAAC,CAAC;QAErF,OAAO,EAAE,CAAC;IACZ,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,wBAAwB,CAC5B,MAAc,EACd,QAAyC;QAEzC,MAAM,MAAM,GAAG,IAAI,CAAC,eAAe,CAAC,GAAG,CAAC,MAAM,CAAC,CAAC;QAChD,IAAI,CAAC,MAAM;YAAE,MAAM,IAAI,KAAK,CAAC,4BAA4B,CAAC,CAAC;QAE3D,MAAM,CAAC,aAAa,GAAG,QAAQ,CAAC;QAChC,MAAM,CAAC,MAAM,GAAG,WAAW,CAAC;QAE5B,IAAI,CAAC,IAAI,CAAC,+BAA+B,EAAE,EAAE,MAAM,EAAE,QAAQ,EAAE,CAAC,CAAC;IACnE,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,gBAAgB,CAAC,cAA2D;QAChF,MAAM,kBAAkB,GAAwB;YAC9C,GAAG,cAAc;YACjB,cAAc,EAAE,IAAI,IAAI,EAAE;SAC3B,CAAC;QAEF,IAAI,CAAC,oBAAoB,CAAC,IAAI,CAAC,kBAAkB,CAAC,CAAC;QACnD,IAAI,CAAC,IAAI,CAAC,oBAAoB,EAAE,kBAAkB,CAAC,CAAC;IACtD,CAAC;IAED;;OAEG;IACH,mBAAmB,CAAC,cAAsC;QAOxD,MAAM,OAAO,GAAG,0BAA0B,cAAc,CAAC,kBAAkB,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,SAAS,CAAC,CAAC,IAAI,CAAC,IAAI,CAAC,WAAW;YACrH,GAAG,cAAc,CAAC,qBAAqB,CAAC,OAAO,uBAAuB;YACtE,GAAG,CAAC,cAAc,CAAC,WAAW,CAAC,YAAY,CAAC,KAAK,GAAG,GAAG,CAAC,CAAC,OAAO,CAAC,CAAC,CAAC,2BAA2B,CAAC;QAEjG,MAAM,iBAAiB,GAAa,EAAE,CAAC;QAEvC,0BAA0B;QAC1B,KAAK,MAAM,EAAE,IAAI,cAAc,CAAC,kBAAkB,EAAE,CAAC;YACnD,iBAAiB,CAAC,IAAI,CAAC,GAAG,EAAE,CAAC,SAAS,IAAI,EAAE,CAAC,MAAM,KAAK,EAAE,CAAC,MAAM,EAAE,CAAC,CAAC;QACvE,CAAC;QAED,yBAAyB;QACzB,KAAK,MAAM,EAAE,IAAI,cAAc,CAAC,kBAAkB,CAAC,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,QAAQ,KAAK,QAAQ,CAAC,EAAE,CAAC;YACxF,iBAAiB,CAAC,IAAI,CAAC,GAAG,EAAE,CAAC,MAAM,KAAK,EAAE,CAAC,WAAW,EAAE,CAAC,CAAC;QAC5D,CAAC;QAED,cAAc;QACd,MAAM,UAAU,GAAG,cAAc,CAAC,kBAAkB,CAAC,GAAG,CAAC,EAAE,CAAC,EAAE,CAAC,CAAC;YAC9D,MAAM,EAAE,GAAG,EAAE,CAAC,SAAS,IAAI,EAAE,CAAC,MAAM,EAAE;YACtC,MAAM,EAAE,IAAI,CAAC,eAAe,CAAC,EAAE,CAAC,MAAM,CAAC;YACvC,MAAM,EAAE,IAAI,CAAC,eAAe,CAAC,EAAE,CAAC,aAAa,CAAC;SAC/C,CAAC,CAAC,CAAC;QAEJ,gBAAgB;QAChB,MAAM,aAAa,GAAa,EAAE,CAAC;QACnC,IAAI,cAAc,CAAC,WAAW,CAAC,YAAY,CAAC,IAAI,CAAC,CAAC,CAAC,GAAG,cAAc,CAAC,WAAW,CAAC,YAAY,CAAC,IAAI,CAAC,CAAC,CAAC,GAAG,GAAG,EAAE,CAAC;YAC5G,aAAa,CAAC,IAAI,CAAC,uDAAuD,CAAC,CAAC;QAC9E,CAAC;QACD,IAAI,cAAc,CAAC,kBAAkB,CAAC,KAAK,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,QAAQ,KAAK,QAAQ,CAAC,EAAE,CAAC;YAC1E,aAAa,CAAC,IAAI,CAAC,wDAAwD,CAAC,CAAC;QAC/E,CAAC;QAED,6BAA6B;QAC7B,MAAM,yBAAyB,GAAG,cAAc,CAAC,kBAAkB,CAAC,GAAG,CAAC,GAAG,CAAC,EAAE,CAC5E,GAAG,GAAG,CAAC,OAAO,KAAK,GAAG,CAAC,mBAAmB,EAAE,CAC7C,CAAC;QAEF,OAAO;YACL,OAAO;YACP,iBAAiB;YACjB,UAAU;YACV,aAAa;YACb,yBAAyB;SAC1B,CAAC;IACJ,CAAC;IAED;;OAEG;IACH,2BAA2B,CAAC,cAAsC;QAOhE,MAAM,QAAQ,GAAG;YACf;gBACE,OAAO,EAAE,GAAG,CAAC,cAAc,CAAC,WAAW,CAAC,YAAY,CAAC,KAAK,GAAG,GAAG,CAAC,CAAC,OAAO,CAAC,CAAC,CAAC,2BAA2B;gBACvG,SAAS,EAAE,cAAc,CAAC,WAAW,CAAC,YAAY,CAAC,KAAK,GAAG,GAAG,CAAC,CAAC,CAAC,MAAe,CAAC,CAAC;oBACvE,cAAc,CAAC,WAAW,CAAC,YAAY,CAAC,KAAK,GAAG,GAAG,CAAC,CAAC,CAAC,UAAmB,CAAC,CAAC,CAAC,KAAc;gBACrG,UAAU,EAAE,cAAc,CAAC,qBAAqB,CAAC,eAAe;aACjE;YACD;gBACE,OAAO,EAAE,cAAc,cAAc,CAAC,WAAW,CAAC,SAAS,CAAC,KAAK,CAAC,OAAO,CAAC,CAAC,CAAC,SAAS;gBACrF,SAAS,EAAE,cAAc,CAAC,WAAW,CAAC,SAAS,CAAC,KAAK,GAAG,EAAE,CAAC,CAAC,CAAC,MAAe,CAAC,CAAC;oBACnE,cAAc,CAAC,WAAW,CAAC,SAAS,CAAC,KAAK,GAAG,CAAC,CAAC,CAAC,CAAC,UAAmB,CAAC,CAAC,CAAC,KAAc;gBAChG,UAAU,EAAE,cAAc,CAAC,qBAAqB,CAAC,eAAe;aACjE;SACF,CAAC;QAEF,MAAM,KAAK,GAAG,cAAc,CAAC,WAAW,CAAC,kBAAkB,CAAC,QAAQ,CAAC,GAAG,CAAC,CAAC,IAAI,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;YACrF,IAAI;YACJ,WAAW,EAAE,cAAc,CAAC,WAAW,CAAC,kBAAkB,CAAC,KAAK,GAAG,CAAC,CAAC,GAAG,CAAC,GAAG,GAAG,CAAC;YAChF,QAAQ,EAAE,UAAmB;YAC7B,UAAU,EAAE,IAAI;SACjB,CAAC,CAAC,CAAC;QAEJ,6BAA6B;QAC7B,MAAM,gBAAgB,GAAG,GAAG,CAAC,CAAC,mBAAmB;QACjD,MAAM,iBAAiB,GAAG,cAAc,CAAC,WAAW,CAAC,YAAY,CAAC,KAAK,CAAC;QACxE,MAAM,eAAe,GAAG,iBAAiB,GAAG,gBAAgB,CAAC;QAC7D,MAAM,mBAAmB,GAAG,eAAe,GAAG,CAAC,CAAC,CAAC,CAAC,IAAI,CAAC,IAAI,CAAC,CAAC,GAAG,eAAe,CAAC,CAAC,CAAC,CAAC,SAAS,CAAC;QAE7F,6BAA6B;QAC7B,MAAM,YAAY,GAAG,cAAc,CAAC,WAAW,CAAC,kBAAkB,CAAC,KAAK,CAAC;QACzE,MAAM,gBAAgB,GAAG,GAAG,CAAC;QAC7B,MAAM,YAAY,GAAG,YAAY,GAAG,gBAAgB,CAAC;QACrD,MAAM,kBAAkB,GAAG,YAAY,GAAG,CAAC,CAAC,CAAC,CAAC,IAAI,CAAC,IAAI,CAAC,CAAC,GAAG,YAAY,CAAC,CAAC,CAAC,CAAC,SAAS,CAAC;QAEtF,MAAM,iBAAiB,GAAG,IAAI,CAAC,yBAAyB,CAAC,QAAQ,EAAE,KAAK,EAAE,mBAAmB,EAAE,kBAAkB,CAAC,CAAC;QAEnH,OAAO;YACL,QAAQ;YACR,KAAK;YACL,iBAAiB;YACjB,mBAAmB;YACnB,kBAAkB;SACnB,CAAC;IACJ,CAAC;IAED,kFAAkF;IAClF,iBAAiB;IACjB,kFAAkF;IAE1E,8BAA8B,CAAC,MAAW;QAChD,wDAAwD;QACxD,IAAI,OAAO,GAAG,kBAAkB,CAAC;QACjC,IAAI,KAAK,GAA6D,EAAE,CAAC;QACzE,IAAI,eAAe,GAAG,IAAI,CAAC;QAE3B,sCAAsC;QACtC,MAAM,WAAW,GAAG,MAAM,CAAC,kBAAkB,IAAI,EAAE,CAAC;QAEpD,gBAAgB;QAChB,IAAI,WAAW,CAAC,IAAI,CAAC,CAAC,CAAM,EAAE,EAAE,CAAC,CAAC,CAAC,IAAI,KAAK,MAAM,CAAC,EAAE,CAAC;YACpD,OAAO,GAAG,aAAa,CAAC;YACxB,KAAK,GAAG,CAAC;oBACP,IAAI,EAAE,aAAa;oBACnB,IAAI,EAAE,MAAM;oBACZ,QAAQ,EAAE,OAAO;oBACjB,KAAK,EAAE,MAAM;iBACd,CAAC,CAAC;YACH,eAAe,GAAG,IAAI,CAAC;QACzB,CAAC;QACD,aAAa;aACR,IAAI,WAAW,CAAC,IAAI,CAAC,CAAC,CAAM,EAAE,EAAE,CAAC,CAAC,CAAC,IAAI,KAAK,KAAK,CAAC,EAAE,CAAC;YACxD,OAAO,GAAG,WAAW,CAAC;YACtB,KAAK,GAAG,CAAC;oBACP,IAAI,EAAE,WAAW;oBACjB,IAAI,EAAE,OAAO;oBACb,QAAQ,EAAE,KAAK;oBACf,KAAK,EAAE,MAAM;iBACd,CAAC,CAAC;YACH,eAAe,GAAG,IAAI,CAAC;QACzB,CAAC;QACD,aAAa;aACR,IAAI,MAAM,CAAC,UAAU,CAAC,IAAI,CAAC,CAAC,CAAM,EAAE,EAAE,CACzC,CAAC,CAAC,IAAI,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,OAAO,CAAC,IAAI,UAAU,CAAC,CAAC,CAAC,KAAK,CAAC,IAAI,EAAE,CACpE,EAAE,CAAC;YACF,OAAO,GAAG,eAAe,CAAC;YAC1B,KAAK,GAAG,CAAC;oBACP,IAAI,EAAE,eAAe;oBACrB,IAAI,EAAE,OAAO;oBACb,QAAQ,EAAE,KAAK;oBACf,KAAK,EAAE,IAAI;iBACZ,CAAC,CAAC;YACH,eAAe,GAAG,IAAI,CAAC;QACzB,CAAC;QACD,uBAAuB;aAClB,CAAC;YACJ,OAAO,GAAG,0CAA0C,CAAC;YACrD,KAAK,GAAG;gBACN,EAAE,IAAI,EAAE,aAAa,EAAE,IAAI,EAAE,OAAO,EAAE,QAAQ,EAAE,KAAK,EAAE,KAAK,EAAE,IAAI,EAAE;gBACpE,EAAE,IAAI,EAAE,YAAY,EAAE,IAAI,EAAE,UAAU,EAAE,QAAQ,EAAE,KAAK,EAAE,KAAK,EAAE,IAAI,EAAE;gBACtE,EAAE,IAAI,EAAE,eAAe,EAAE,IAAI,EAAE,OAAO,EAAE,QAAQ,EAAE,KAAK,EAAE,KAAK,EAAE,IAAI,EAAE;aACvE,CAAC;YACF,eAAe,GAAG,IAAI,CAAC;QACzB,CAAC;QAED,OAAO;YACL,OAAO;YACP,KAAK;YACL,OAAO,EAAE,MAAM,CAAC,cAAc,EAAE,MAAM,GAAG,CAAC,CAAC,CAAC,CAAC,aAAa,CAAC,CAAC,CAAC,YAAY;YACzE,eAAe;SAChB,CAAC;IACJ,CAAC;IAEO,qBAAqB,CAAC,MAAW;QACvC,mCAAmC;QACnC,OAAO;YACL;gBACE,OAAO,EAAE,gBAAgB;gBACzB,KAAK,EAAE,CAAC,uBAAuB,CAAC;gBAChC,eAAe,EAAE,GAAG;gBACpB,mBAAmB,EAAE,2DAA2D;aACjF;YACD;gBACE,OAAO,EAAE,8BAA8B;gBACvC,KAAK,EAAE,CAAC,WAAW,CAAC;gBACpB,eAAe,EAAE,IAAI;gBACrB,mBAAmB,EAAE,8CAA8C;aACpE;SACF,CAAC;IACJ,CAAC;IAEO,cAAc,CAAC,MAAW;QAChC,MAAM,QAAQ,GAAiD,EAAE,CAAC;QAElE,yBAAyB;QACzB,QAAQ,CAAC,IAAI,CAAC;YACZ,IAAI,EAAE,WAAW;YACjB,MAAM,EAAE,iBAAiB;YACzB,WAAW,EAAE,mBAAmB,MAAM,CAAC,UAAU,UAAU,MAAM,CAAC,KAAK,EAAE;YACzE,QAAQ,EAAE,QAAQ;YAClB,GAAG,EAAE,iCAAiC;SACvC,CAAC,CAAC;QAEH,kDAAkD;QAClD,IAAI,MAAM,CAAC,kBAAkB,EAAE,IAAI,CAAC,CAAC,CAAM,EAAE,EAAE,CAAC,CAAC,CAAC,IAAI,KAAK,MAAM,CAAC,EAAE,CAAC;YACnE,QAAQ,CAAC,IAAI,CAAC;gBACZ,IAAI,EAAE,gBAAgB;gBACtB,MAAM,EAAE,cAAc;gBACtB,WAAW,EAAE,sEAAsE;gBACnF,QAAQ,EAAE,QAAQ;aACnB,CAAC,CAAC;QACL,CAAC;QAED,IAAI,MAAM,CAAC,UAAU,EAAE,IAAI,CAAC,CAAC,CAAM,EAAE,EAAE,CACrC,CAAC,CAAC,IAAI,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,OAAO,CAAC,IAAI,UAAU,CAAC,CAAC,CAAC,KAAK,CAAC,IAAI,EAAE,CACpE,EAAE,CAAC;YACF,QAAQ,CAAC,IAAI,CAAC;gBACZ,IAAI,EAAE,gBAAgB;gBACtB,MAAM,EAAE,aAAa;gBACrB,WAAW,EAAE,yDAAyD;gBACtE,QAAQ,EAAE,QAAQ;aACnB,CAAC,CAAC;QACL,CAAC;QAED,OAAO,QAAQ,CAAC;IAClB,CAAC;IAEO,0BAA0B,CAChC,UAAuE,EACvE,WAAmD;QAEnD,MAAM,SAAS,GAAiD,EAAE,CAAC;QAEnE,KAAK,MAAM,GAAG,IAAI,WAAW,EAAE,CAAC;YAC9B,SAAS,CAAC,IAAI,CAAC;gBACb,SAAS,EAAE,GAAG,CAAC,IAAI;gBACnB,MAAM,EAAE,GAAG,CAAC,UAAU;gBACtB,MAAM,EAAE,IAAI,CAAC,kBAAkB,CAAC,GAAG,CAAC,IAAI,EAAE,GAAG,CAAC,UAAU,CAAC;gBACzD,aAAa,EAAE,IAAI,CAAC,yBAAyB,CAAC,GAAG,CAAC,IAAI,CAAC;aACxD,CAAC,CAAC;QACL,CAAC;QAED,KAAK,MAAM,EAAE,IAAI,UAAU,EAAE,CAAC;YAC5B,IAAI,CAAC,SAAS,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,SAAS,KAAK,EAAE,CAAC,IAAI,CAAC,EAAE,CAAC;gBAClD,SAAS,CAAC,IAAI,CAAC;oBACb,SAAS,EAAE,EAAE,CAAC,IAAI;oBAClB,MAAM,EAAE,MAAM,CAAC,EAAE,CAAC,KAAK,CAAC;oBACxB,MAAM,EAAE,IAAI,CAAC,kBAAkB,CAAC,EAAE,CAAC,IAAI,EAAE,MAAM,CAAC,EAAE,CAAC,KAAK,CAAC,CAAC;oBAC1D,aAAa,EAAE,IAAI,CAAC,yBAAyB,CAAC,EAAE,CAAC,IAAI,CAAC;iBACvD,CAAC,CAAC;YACL,CAAC;QACH,CAAC;QAED,OAAO,SAAS,CAAC;IACnB,CAAC;IAEO,kBAAkB,CAAC,SAAiB,EAAE,KAAa;QACzD,MAAM,OAAO,GAA2B;YACtC,MAAM,EAAE,+BAA+B;YACvC,KAAK,EAAE,8BAA8B;YACrC,MAAM,EAAE,6CAA6C;YACrD,WAAW,EAAE,mCAAmC;YAChD,OAAO,EAAE,UAAU,CAAC,KAAK,CAAC,IAAI,EAAE,CAAC,CAAC,CAAC,8CAA8C,CAAC,CAAC;gBAC1E,UAAU,CAAC,KAAK,CAAC,IAAI,CAAC,CAAC,CAAC,CAAC,gCAAgC,CAAC,CAAC;oBAC3D,oCAAoC;YAC7C,OAAO,EAAE,8CAA8C;YACvD,KAAK,EAAE,oCAAoC;SAC5C,CAAC;QAEF,OAAO,OAAO,CAAC,SAAS,CAAC,IAAI,yBAAyB,CAAC;IACzD,CAAC;IAEO,yBAAyB,CAAC,SAAiB;QACjD,MAAM,WAAW,GAAG,CAAC,MAAM,EAAE,KAAK,EAAE,MAAM,EAAE,MAAM,EAAE,MAAM,EAAE,KAAK,EAAE,KAAK,EAAE,WAAW,EAAE,MAAM,CAAC,CAAC;QAC/F,IAAI,WAAW,CAAC,QAAQ,CAAC,SAAS,CAAC;YAAE,OAAO,cAAc,CAAC;QAE3D,MAAM,eAAe,GAAG,CAAC,OAAO,EAAE,OAAO,EAAE,KAAK,CAAC,CAAC;QAClD,IAAI,eAAe,CAAC,QAAQ,CAAC,SAAS,CAAC;YAAE,OAAO,kBAAkB,CAAC;QAEnE,OAAO,mBAAmB,CAAC;IAC7B,CAAC;IAEO,mBAAmB,CAAC,MAAW;QACrC,8DAA8D;QAC9D,IAAI,YAAY,GAAG,GAAG,CAAC;QACvB,IAAI,GAAG,GAAG,CAAC,CAAC;QACZ,IAAI,EAAE,GAAG,EAAE,CAAC;QACZ,IAAI,YAAY,GAAG,IAAI,CAAC;QAExB,6BAA6B;QAC7B,IAAI,MAAM,CAAC,kBAAkB,EAAE,IAAI,CAAC,CAAC,CAAM,EAAE,EAAE,CAAC,CAAC,MAAM,EAAE,KAAK,EAAE,MAAM,CAAC,CAAC,QAAQ,CAAC,CAAC,CAAC,IAAI,CAAC,CAAC,EAAE,CAAC;YAC1F,YAAY,GAAG,IAAI,CAAC;YACpB,GAAG,GAAG,EAAE,CAAC;YACT,EAAE,GAAG,EAAE,CAAC;YACR,YAAY,GAAG,IAAI,CAAC;QACtB,CAAC;QAED,wBAAwB;QACxB,MAAM,IAAI,GAAG,MAAM,CAAC,UAAU,EAAE,IAAI,CAAC,CAAC,CAAM,EAAE,EAAE,CAAC,CAAC,CAAC,IAAI,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,OAAO,CAAC,CAAC,CAAC;QACzF,IAAI,IAAI,IAAI,UAAU,CAAC,IAAI,CAAC,KAAK,CAAC,IAAI,EAAE,EAAE,CAAC;YACzC,YAAY,GAAG,IAAI,CAAC,GAAG,CAAC,YAAY,EAAE,IAAI,CAAC,CAAC;QAC9C,CAAC;QAED,qCAAqC;QACrC,IAAI,MAAM,CAAC,iBAAiB,IAAI,MAAM,CAAC,iBAAiB,IAAI,CAAC,EAAE,CAAC;YAC9D,YAAY,IAAI,GAAG,CAAC;YACpB,GAAG,IAAI,GAAG,CAAC;YACX,EAAE,IAAI,GAAG,CAAC;YACV,YAAY,IAAI,GAAG,CAAC;QACtB,CAAC;QAED,OAAO;YACL,YAAY,EAAE;gBACZ,KAAK,EAAE,YAAY;gBACnB,IAAI,EAAE,CAAC,YAAY,GAAG,GAAG,EAAE,IAAI,CAAC,GAAG,CAAC,YAAY,GAAG,GAAG,EAAE,IAAI,CAAC,CAAC;aAC/D;YACD,SAAS,EAAE;gBACT,KAAK,EAAE,GAAG;gBACV,IAAI,EAAE,CAAC,GAAG,GAAG,IAAI,EAAE,GAAG,GAAG,GAAG,CAAC;gBAC7B,IAAI,EAAE,QAAQ;aACf;YACD,QAAQ,EAAE;gBACR,KAAK,EAAE,EAAE;gBACT,IAAI,EAAE,CAAC,EAAE,GAAG,GAAG,EAAE,EAAE,GAAG,GAAG,CAAC;gBAC1B,IAAI,EAAE,QAAQ;aACf;YACD,kBAAkB,EAAE;gBAClB,KAAK,EAAE,YAAY;gBACnB,QAAQ,EAAE,CAAC,aAAa,EAAE,SAAS,EAAE,QAAQ,CAAC;aAC/C;YACD,aAAa,EAAE;gBACb,KAAK,EAAE,IAAI;gBACX,cAAc,EAAE,CAAC,yCAAyC,EAAE,sCAAsC,CAAC;aACpG;SACF,CAAC;IACJ,CAAC;IAEO,sBAAsB,CAAC,MAAW;QACxC,MAAM,cAAc,GAAqD,EAAE,CAAC;QAE5E,qBAAqB;QACrB,IAAI,MAAM,CAAC,iBAAiB,IAAI,MAAM,CAAC,iBAAiB,IAAI,CAAC,EAAE,CAAC;YAC9D,cAAc,CAAC,IAAI,CAAC;gBAClB,QAAQ,EAAE,QAAQ;gBAClB,aAAa,EAAE,mDAAmD;gBAClE,UAAU,EAAE,UAAU;aACvB,CAAC,CAAC;QACL,CAAC;QAED,gBAAgB;QAChB,IAAI,MAAM,CAAC,cAAc,IAAI,MAAM,CAAC,cAAc,CAAC,MAAM,GAAG,CAAC,EAAE,CAAC;YAC9D,cAAc,CAAC,IAAI,CAAC;gBAClB,QAAQ,EAAE,UAAU;gBACpB,aAAa,EAAE,sDAAsD;gBACrE,UAAU,EAAE,WAAW;aACxB,CAAC,CAAC;QACL,CAAC;QAED,gBAAgB;QAChB,IAAI,MAAM,CAAC,aAAa,EAAE,IAAI,CAAC,CAAC,CAAS,EAAE,EAAE,CAAC,CAAC,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,OAAO,CAAC,CAAC,EAAE,CAAC;YACjF,cAAc,CAAC,IAAI,CAAC;gBAClB,QAAQ,EAAE,QAAQ;gBAClB,aAAa,EAAE,oDAAoD;gBACnE,UAAU,EAAE,UAAU;aACvB,CAAC,CAAC;QACL,CAAC;QAED,OAAO,cAAc,CAAC;IACxB,CAAC;IAEO,sBAAsB,CAAC,MAAW;QACxC,OAAO;YACL,EAAE,IAAI,EAAE,uBAAuB,EAAE,SAAS,EAAE,mBAAmB,EAAE,SAAS,EAAE,8BAA8B,EAAE;YAC5G,EAAE,IAAI,EAAE,+BAA+B,EAAE,SAAS,EAAE,mBAAmB,EAAE,SAAS,EAAE,+BAA+B,EAAE;YACrH,EAAE,IAAI,EAAE,4BAA4B,EAAE,SAAS,EAAE,kBAAkB,EAAE,SAAS,EAAE,8BAA8B,EAAE;YAChH,EAAE,IAAI,EAAE,qBAAqB,EAAE,SAAS,EAAE,YAAY,EAAE,SAAS,EAAE,4BAA4B,EAAE;SAClG,CAAC;IACJ,CAAC;IAEO,eAAe,CAAC,UAAkB;QACxC,IAAI,UAAU,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,WAAW,CAAC;YAC9C,UAAU,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,UAAU,CAAC;YAC7C,UAAU,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,SAAS,CAAC,EAAE,CAAC;YACjD,OAAO,UAAU,CAAC;QACpB,CAAC;QACD,IAAI,UAAU,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,WAAW,CAAC;YAC9C,UAAU,CAAC,WAAW,EAAE,CAAC,QAAQ,CAAC,MAAM,CAAC,EAAE,CAAC;YAC9C,OAAO,UAAU,CAAC;QACpB,CAAC;QACD,OAAO,SAAS,CAAC;IACnB,CAAC;IAEO,eAAe,CAAC,aAAqB;QAC3C,MAAM,OAAO,GAA2B;YACtC,cAAc,EAAE,GAAG;YACnB,kBAAkB,EAAE,GAAG;YACvB,mBAAmB,EAAE,GAAG;YACxB,aAAa,EAAE,GAAG;SACnB,CAAC;QACF,OAAO,OAAO,CAAC,aAAa,CAAC,IAAI,GAAG,CAAC;IACvC,CAAC;IAEO,yBAAyB,CAC/B,QAAiC,EACjC,KAAkD,EAClD,GAAY,EACZ,GAAY;QAEZ,MAAM,YAAY,GAAG,QAAQ,CAAC,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,SAAS,KAAK,MAAM,CAAC,CAAC,MAAM,CAAC;QACzE,MAAM,WAAW,GAAG,KAAK,CAAC,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,QAAQ,KAAK,QAAQ,IAAI,CAAC,CAAC,WAAW,GAAG,GAAG,CAAC,CAAC,MAAM,CAAC;QAE7F,IAAI,YAAY,IAAI,CAAC,IAAI,WAAW,KAAK,CAAC,EAAE,CAAC;YAC3C,OAAO,iEAAiE,CAAC;QAC3E,CAAC;QACD,IAAI,YAAY,IAAI,CAAC,IAAI,WAAW,IAAI,CAAC,EAAE,CAAC;YAC1C,OAAO,qFAAqF,CAAC;QAC/F,CAAC;QACD,IAAI,WAAW,IAAI,CAAC,EAAE,CAAC;YACrB,OAAO,oFAAoF,CAAC;QAC9F,CAAC;QACD,OAAO,kFAAkF,CAAC;IAC5F,CAAC;IAED;;OAEG;IACH,kBAAkB,CAAC,SAAe,EAAE,OAAa;QAW/C,MAAM,eAAe,GAAG,KAAK,CAAC,IAAI,CAAC,IAAI,CAAC,eAAe,CAAC,MAAM,EAAE,CAAC;aAC9D,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,WAAW,IAAI,SAAS,IAAI,CAAC,CAAC,WAAW,IAAI,OAAO,CAAC,CAAC;QAEvE,MAAM,YAAY,GAAG,KAAK,CAAC,IAAI,CAAC,IAAI,CAAC,SAAS,CAAC,MAAM,EAAE,CAAC,CAAC,IAAI,EAAE;aAC5D,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,SAAS,IAAI,SAAS,IAAI,CAAC,CAAC,SAAS,IAAI,OAAO,CAAC,CAAC;QAEnE,MAAM,KAAK,GAAG,KAAK,CAAC,IAAI,CAAC,IAAI,CAAC,eAAe,CAAC,MAAM,EAAE,CAAC;aACpD,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,aAAa,IAAI,SAAS,IAAI,CAAC,CAAC,aAAa,IAAI,OAAO,CAAC,CAAC;QAE3E,+BAA+B;QAC/B,MAAM,QAAQ,GAAG,eAAe,CAAC,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,MAAM,KAAK,UAAU,CAAC,CAAC,MAAM,CAAC;QAC7E,MAAM,UAAU,GAAG,eAAe,CAAC,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,MAAM,KAAK,UAAU,IAAI,CAAC,CAAC,MAAM,KAAK,UAAU,CAAC,CAAC,MAAM,CAAC;QAE1G,yBAAyB;QACzB,MAAM,YAAY,GAAG,IAAI,GAAG,EAA4B,CAAC;QACzD,KAAK,MAAM,QAAQ,IAAI,YAAY,EAAE,CAAC;YACpC,MAAM,KAAK,GAAG,YAAY,CAAC,GAAG,CAAC,QAAQ,CAAC,MAAM,CAAC,QAAQ,CAAC,IAAI,CAAC,CAAC;YAC9D,YAAY,CAAC,GAAG,CAAC,QAAQ,CAAC,MAAM,CAAC,QAAQ,EAAE,KAAK,GAAG,CAAC,CAAC,CAAC;QACxD,CAAC;QAED,MAAM,qBAAqB,GAAG,KAAK,CAAC,IAAI,CAAC,YAAY,CAAC,OAAO,EAAE,CAAC;aAC7D,GAAG,CAAC,CAAC,CAAC,MAAM,EAAE,KAAK,CAAC,EAAE,EAAE,CAAC,CAAC,EAAE,MAAM,EAAE,KAAK,EAAE,CAAC,CAAC;aAC7C,IAAI,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,KAAK,GAAG,CAAC,CAAC,KAAK,CAAC,CAAC;QAErC,OAAO;YACL,eAAe;YACf,SAAS,EAAE,YAAY;YACvB,eAAe,EAAE,KAAK;YACtB,OAAO,EAAE;gBACP,oBAAoB,EAAE,eAAe,CAAC,MAAM;gBAC5C,cAAc,EAAE,eAAe,CAAC,MAAM,GAAG,CAAC,CAAC,CAAC,CAAC,QAAQ,GAAG,eAAe,CAAC,MAAM,CAAC,CAAC,CAAC,CAAC;gBAClF,YAAY,EAAE,eAAe,CAAC,MAAM,GAAG,CAAC,CAAC,CAAC,CAAC,UAAU,GAAG,eAAe,CAAC,MAAM,CAAC,CAAC,CAAC,CAAC;gBAClF,qBAAqB;aACtB;SACF,CAAC;IACJ,CAAC;CACF;AAED,eAAe,8BAA8B,CAAC"}

package/dist/clinician/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * Clinician Decision Support Module Exports
+ */
+export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator, type ClinicalRecommendation, type OverrideRecord, type TumorBoardCase, type RiskBenefitAnalysis, type RecommendationExplanation, type DecisionSupportConfig } from './decisionSupport.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/clinician/index.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../src/clinician/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,uBAAuB,EACvB,oBAAoB,EACpB,eAAe,EACf,iBAAiB,EACjB,mBAAmB,EACnB,oBAAoB,EACpB,KAAK,sBAAsB,EAC3B,KAAK,cAAc,EACnB,KAAK,cAAc,EACnB,KAAK,mBAAmB,EACxB,KAAK,yBAAyB,EAC9B,KAAK,qBAAqB,EAC3B,MAAM,sBAAsB,CAAC"}

package/dist/clinician/index.js

@@ -0,0 +1,5 @@
+/**
+ * Clinician Decision Support Module Exports
+ */
+export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator } from './decisionSupport.js';
+//# sourceMappingURL=index.js.map

package/dist/clinician/index.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/clinician/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,uBAAuB,EACvB,oBAAoB,EACpB,eAAe,EACf,iBAAiB,EACjB,mBAAmB,EACnB,oBAAoB,EAOrB,MAAM,sBAAsB,CAAC"}

package/dist/compliance/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * HIPAA Compliance Module Exports
+ */
+export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService, type AuditLogEntry, type PatientConsent, type ConsentScope, type AccessPolicy, type AccessDecision, type HIPAAConfig } from './hipaa.js';
+//# sourceMappingURL=index.d.ts.map