@datagrok/bio 2.9.0 → 2.10.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (24) hide show
  1. package/CHANGELOG.md +16 -1
  2. package/dist/452.js +1 -1
  3. package/dist/452.js.map +1 -1
  4. package/dist/package-test.js +1 -1
  5. package/dist/package-test.js.map +1 -1
  6. package/dist/package.js +1 -1
  7. package/dist/package.js.map +1 -1
  8. package/package.json +4 -4
  9. package/src/analysis/sequence-space.ts +5 -6
  10. package/src/apps/get-region-app.ts +56 -0
  11. package/src/apps/web-logo-app.ts +3 -6
  12. package/src/package-test.ts +1 -0
  13. package/src/package-types.ts +13 -0
  14. package/src/package.ts +152 -52
  15. package/src/tests/converters-test.ts +2 -3
  16. package/src/tests/scoring.ts +8 -4
  17. package/src/tests/units-handler-get-region.ts +116 -0
  18. package/src/utils/cell-renderer.ts +5 -32
  19. package/src/utils/context-menu.ts +2 -3
  20. package/src/utils/convert.ts +6 -7
  21. package/src/utils/get-region-func-editor.ts +241 -0
  22. package/src/utils/get-region.ts +65 -0
  23. package/src/utils/multiple-sequence-alignment-ui.ts +21 -17
  24. package/src/viewers/web-logo-viewer.ts +8 -6
package/dist/package.js CHANGED
@@ -1,2 +1,2 @@
1
- var bio;(()=>{var t={6e3:(t,e,s)=>{"use strict";var i;s(4469),s(976),function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(i||(i={}))},7997:(t,e,s)=>{"use strict";function i(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function n(t){let e=0;for(let s=0;s<t.length;s++)e+=t[s]*t[s];return Math.sqrt(e)}function r(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let s=0;for(let i=0;i<t.length;i++)s+=t[i]*e[i];return s}s.d(e,{$G:()=>n,MA:()=>r,hu:()=>i})},2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>n});var i=s(9976);class n extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,n)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,n)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new n({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in n.aaSynonyms?n.aaSynonyms[t]:t;return super.get(e)}}n.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return n.GrokGroups;case"lesk":return n.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",i="";for(const n of t)"("==n?e++:")"==n?e--:e?s+=n:i+=n;return isNaN(parseInt(s))?[i,s]:[i,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[i,n]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,n=n.length>6?`${n.slice(0,3)}...`:n,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,n,1]:[this.undefinedColor,i,n,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,n,2]:[this.undefinedColor,i,n,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,n,3]:[this.undefinedColor,i,n,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,n,4]:[this.undefinedColor,i,n,4]}return[this.undefinedColor,i,n,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>l,Qx:()=>h,Xk:()=>a});var i=s(976),n=s(4469),r=s(1047),o=(s(499),s(8457));function a(t){const e=[];for(let s=0;s<t.rowCount;s++){const i={};Object.keys(r.K4).forEach((e=>{if("symbol"===e){const n=t.get(r.K4[e],s);i[e]="."===n?t.get(r.At,s):n}else if("rgroups"===e){const n=t.get(r.K4[e],s).split("\n"),o=[];n.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===s?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${i}`,o.push(e)})),i[e]=o}else r.K4[e]&&(i[e]=t.get(r.K4[e],s))})),e.push(i)}return e}async function l(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function h(t,e){t instanceof i.Column&&(t=(0,o.O)(t).columns.toList());const s=(await l()).getBioLib(),r=new Array(t.length),a=t[0].length,h=new Float32Array(a);for(let o=0;o<t.length;++o){const l=e[o],c=s.getMonomer("PEPTIDE",l)?.smiles??"",u=t[o],m=u.getRawData(),d=u.categories,p=d.indexOf("");if(r[o]={categories:d,data:m,emptyIndex:p},void 0===l)continue;const g=i.Column.fromStrings("smiles",d.map((t=>s.getMonomer("PEPTIDE",t)?.smiles??""))),f=(i.DataFrame.fromColumns([g]),(await n.chem.getSimilarities(g,c)).getRawData());for(let t=0;t<a;++t){const e=m[t];h[t]+=""!==l&&e!==p?f[e]:""===l&&e===p?1:0}}for(let s=0;s<h.length;++s){let n=h[s]/e.length;for(let o=0;o<t.length;++o){const t=r[o];if(o>=e.length&&t.data[s]!==t.emptyIndex||t.data[s]===t.emptyIndex&&o<e.length){n=i.FLOAT_NULL;break}}h[s]=n}return i.Column.fromFloat32Array("Similarity",h)}},6375:(t,e,s)=>{"use strict";s.d(e,{i0:()=>p});var i=s(4469),n=s(976),r=s(6414),o=s.n(r);function a(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?a(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}s(6e3);var l=s(1821),h=s(7767),c=s(499);const u={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG:",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var m=s(1047);function d(t){return Math.round(u.PRECISION_FACTOR*t)/u.PRECISION_FACTOR}async function p(t,e,r){if(0===n.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(e.semType!==n.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${n.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let d=e;c.Cn.getOrCreate(e).isHelm()&&(d=new h.L(e).convert(l.r2.SEPARATOR,"."),d.name=e.name);const p=c.Cn.getOrCreate(d).alphabet;let f;if("PT"===p||"UN"===p)f="PEPTIDE";else{if("RNA"!==p&&"DNA"!==p)return{col:null,warnings:[`Unexpected column's '${d.name}' alphabet '${p}'.`]};f="RNA"}const y=function(t){const e=t.length,s=new Array(e),i=c.Cn.getOrCreate(t).getSplitter();for(let n=0;n<e;++n){const e=t.get(n);s[n]=e?o()(i(e)).filter((t=>""!==t)).toArray():[]}return s}(d),w=await async function(t,e,s,n){const r=function(t,e,s){const i=new Map;for(const n of t.getMonomerSymbolsByType(e)){const r=t.getMonomer(e,n);if("RNA"===e&&("Branch"===r.monomerType||"DNA"===s&&r.symbol===u.DEOXYRIBOSE||"RNA"===s&&r.symbol===u.RIBOSE||r.symbol===u.PHOSPHATE)||"PEPTIDE"===e&&"Branch"!==r.monomerType){const t={};m.rx.forEach((e=>{t[e]=r[e]})),i.set(r.symbol,t)}}return i}(e,s,n),o=new Map,l=await i.functions.call("Chem:getRdKitModule"),h={value:null};if("RNA"===s){const t="RNA"===n?[u.RIBOSE,u.PHOSPHATE]:[u.DEOXYRIBOSE,u.PHOSPHATE];for(const e of t)g(o,e,r,l,s,h)}for(let e=0;e<t.length;++e){const i=t[e];for(const t of i)if(""!==t)try{g(o,t,r,l,s,h)}catch(e){const s=a(e);throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n`+s),new Error(`Сan't get monomer '${t}' from library: ${s}`)}}return o}(y,r,f,p),b=d.length,{molfileList:v,molfileWarningList:C}=await async function(t,e,i,n,r){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=r/o;let h=[],c=[];const u=new Array(o);for(let s=0;s<o;s++){const h=Math.floor(s*l),c=s===o-1?r:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:i,polymerType:n,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(y,w,p,f,b);if(C.length>.05*b)throw new Error("Too many errors getting molfiles.");const S=`molfile(${d.name})`,M=t.columns.getUnusedName(S),A=n.Column.fromStrings(M,v);return A.semType=n.SEMTYPE.MOLECULE,A.setTag(n.TAGS.UNITS,n.UNITS.Molecule.MOLBLOCK),{col:A,warnings:C}}function g(t,e,s,i,n,r){if(!t.has(e)){const o=function(t,e,s,i,n){if(e.has(t)){const r=e.get(t),o=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(r.rgroups),a=function(t){const e=new Map;let s=t.indexOf(u.V2K_A_LINE,0),i=s;for(;-1!==s;){i=t.indexOf("\n",s);const n=parseInt(t.substring(s,i).replace(/^A\s+/,""));s=t.indexOf("R",i),i=t.indexOf("\n",s);const r=parseInt(t.substring(s,i).replace(/^R/,""));e.set(n,r),s=t.indexOf(u.V2K_A_LINE,i)}for(s=t.indexOf(u.V2K_RGP_LINE,0),i=t.indexOf("\n",s);-1!==s;){s+=u.V2K_RGP_SHIFT,i=t.indexOf("\n",s);const n=t.substring(s,i).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<n.length;t+=2){if(e.has(n[t])&&e.get(n[t])!==n[t+1])throw new Error(`r-group index ${n[t]} has already been added with a different value`);e.set(n[t],n[t+1])}s=t.indexOf(u.V2K_RGP_LINE,i)}return e}(r.molfile),l=function(t,e){const s=e.get_mol(t),i=s.get_v3Kmolblock();return s.delete(),i}(function(t){let e=t.indexOf(u.V2K_A_LINE,0);-1===e&&(e=t.indexOf(u.V2K_RGP_LINE));const s=t.indexOf(u.V3K_END,e);return t.substring(0,e)+t.substring(s)}(r.molfile),s),h=function(t){let e=(t=t.replaceAll("\r","")).indexOf(u.V3K_BEGIN_COUNTS_LINE)+u.V3K_COUNTS_SHIFT,s=t.indexOf(" ",e+1);const i=parseInt(t.substring(e,s));return e=s+1,s=t.indexOf(" ",e+1),{atomCount:i,bondCount:parseInt(t.substring(e,s))}}(l),c=function(t,e){const s=new Array(e),i=new Float32Array(e),n=new Float32Array(e),r=new Array(e);let o=t.indexOf(u.V3K_BEGIN_ATOM_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;l++){o=t.indexOf(u.V3K_BEGIN_DATA_LINE,o)+u.V3K_IDX_SHIFT,a=t.indexOf(" ",o),o=a+1,a=t.indexOf(" ",o),s[l]=t.substring(o,a);const e=new Array(2);for(let s=0;s<2;++s)o=a+1,a=t.indexOf(" ",o),e[s]=parseFloat(t.substring(o,a));i[l]=e[0],n[l]=e[1],o=a,a=t.indexOf("\n",o)+1,r[l]=t.slice(o,a),o=a}return{atomTypes:s,x:i,y:n,kwargs:r}}(l,h.atomCount),m=function(t,e){const s=new Uint32Array(e),i=new Array(e),n=new Map,r=new Map;let o=t.indexOf(u.V3K_BEGIN_BOND_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;++l){const e=new Array(3);o=t.indexOf(u.V3K_BEGIN_DATA_LINE,a)+u.V3K_IDX_SHIFT,a=t.indexOf(" ",o);for(let s=0;s<3;++s)o=a+1,a=Math.min(t.indexOf("\n",o),t.indexOf(" ",o)),e[s]=parseInt(t.slice(o,a));s[l]=e[0],i[l]=e.slice(1);const h=t.indexOf("\n",o);let c=t.slice(a,h),m=c.indexOf(u.V3K_BOND_CONFIG);if(-1!==m){m=c.indexOf("=",m)+1;let t=c.indexOf(" ",m);-1===t&&(t=c.length);const e=parseInt(c.slice(m,t));n.set(l,e);const s=u.V3K_BOND_CONFIG+e.toString();c=c.replace(s,"")}c||r.set(l,c)}return{bondTypes:s,atomPairs:i,bondConfiguration:n,kwargs:r}}(l,h.bondCount),p={atoms:c,bonds:m,meta:f(c,m,o,a)};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,i=t.atoms.x,n=t.atoms.y;T(t,-i[e],-n[e]);const r=S(i[s],n[s]);M(t.atoms,-r),i[t.meta.rNodes[1]-1]<0&&function(t){A(t,!1)}(t);const o=function(t){const e=function(t){const e=new Map;for(const s of t.bonds.atomPairs)for(let t=0;t<2;t++){const i=s[t],n=s[(t+1)%2];e.has(i)?e.get(i)?.push(n):e.set(i,new Array(1).fill(n))}return e}(t);let s=0,i=0;for(;0===s;){const n=e.get(t.meta.terminalNodes[1])[i];t.atoms.atomTypes[n-1]===u.OXYGEN&&n!==t.meta.rNodes[1]&&(s=n),i++}return s}(t);!function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){A(t,!0)}(t),M(t.atoms,-function(t,e){return S(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,o),function(t,e){const s=t.atoms.x;s[t.meta.rNodes[1]-1]>s[e-1]&&function(t,e,s){const i=e-1,n=s-1,r=t.atoms.x,o=t.atoms.y,a=r[i],l=o[i];r[i]=r[n],o[i]=o[n],r[n]=a,o[n]=l}(t,e,t.meta.rNodes[1])}(t,o)}(p):t===u.RIBOSE||t===u.DEOXYRIBOSE?function(t,e){const s=t.atoms.x,i=t.atoms.y;let n=t.meta.terminalNodes[0]-1;const r=t.meta.rNodes[1]-1;T(t,-s[n],-i[n]);const o=S(s[r],i[r]);M(t.atoms,3*Math.PI/2-o),e.value=function(t){const e=t.atoms.x,s=t.atoms.y,i=t.meta.rNodes[2]-1,n=t.meta.terminalNodes[2]-1,r=e[i]-e[n],o=s[i]-s[n];return Math.atan(o/r)+Math.PI/2}(t),n=t.meta.terminalNodes[0]-1,T(t,-s[n],-i[n])}(p,n):t===u.PHOSPHATE?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,i=t.atoms.x,n=t.atoms.y;T(t,-i[e],-n[e]);const r=S(i[s],n[s]);M(t.atoms,Math.PI/2-r)}(p):function(t,e){const s=t.atoms.x,i=t.atoms.y,n=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;T(t,-s[n],-i[n]);const o=S(s[r],i[r]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");M(t.atoms,Math.PI-o+a);const l=function(t,e){return d(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:s[t.meta.rNodes[0]-1],y:i[t.meta.rNodes[0]-1]},{x:s[t.meta.terminalNodes[0]-1],y:i[t.meta.terminalNodes[0]-1]});if(1!=l)for(let t=0;t<s.length;++t)s[t]=d(s[t]/l),i[t]=d(i[t]/l)}(p,n),function(t,e,s){"PEPTIDE"===t?(w(e,t),v(e,e.meta.rNodes[1])):s===u.RIBOSE||s===u.DEOXYRIBOSE?(v(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],y(e.bonds,e.meta),w(e,t),v(e,e.meta.rNodes[1]),v(e,e.meta.rNodes[0]),v(e,e.meta.rNodes[2])):s===u.PHOSPHATE&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],T(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),w(e,t),v(e,e.meta.rNodes[1]))}(i,p,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===u.HYDROGEN&&(v(t,e+1),--e),++e}(p),p}return null}(e,s,i,n,r);if(!o)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);t.set(e,o)}}function f(t,e,s,i){const n={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(t,e,s){for(const[i,n]of s)t.atomTypes[i-1]=e[n-1]}(t,s,i),function(t,e){e.rNodes=Array.from(t.keys());for(let s=0;s<e.rNodes.length;s++)for(const i of[1,2])if(t.get(e.rNodes[s])===i){const t=e.rNodes[i-1];e.rNodes[i-1]=e.rNodes[s],e.rNodes[s]=t}}(i,n),y(e,n),n}function y(t,e){const s=e.rNodes;e.terminalNodes=new Array(s.length).fill(0);const i=e.terminalNodes,n=t.atomPairs;let r=0,o=0;for(;r<n.length&&o<i.length;){for(let t=0;t<i.length;++t)for(let e=0;e<2;++e)n[r][e]===s[t]&&(i[t]=n[r][(e+1)%2],s.length,++o);++r}}function w(t,e){t.meta.rNodes.length>1&&(t.meta.backboneShift=b(t,t.meta.rNodes[1]-1,t.meta.terminalNodes[0]-1)),"RNA"===e&&t.meta.rNodes.length>2&&(t.meta.branchShift=b(t,t.meta.rNodes[2]-1,t.meta.terminalNodes[0]-1))}function b(t,e,s){return[d(t.atoms.x[e]-t.atoms.x[s]),d(t.atoms.y[e]-t.atoms.y[s])]}function v(t,e){if(void 0!==e){const s=e-1,i=t.atoms,n=t.bonds,r=t.meta;i.atomTypes.splice(s,1),i.x=C(Float32Array,i.x,s,1),i.y=C(Float32Array,i.y,s,1),i.kwargs.splice(s,1);for(let t=0;t<r.terminalNodes.length;++t)r.terminalNodes[t]>e?--r.terminalNodes[t]:r.terminalNodes[t]===e&&(r.terminalNodes[t]=-1);for(let t=0;t<r.rNodes.length;++t)r.rNodes[t]>e?--r.rNodes[t]:r.rNodes[t]===e&&(r.rNodes[t]=-1);let o=0;for(;o<n.atomPairs.length;){const t=n.atomPairs[o][0],s=n.atomPairs[o][1];t===e||s===e?(n.atomPairs.splice(o,1),n.bondTypes=C(Uint32Array,n.bondTypes,o,1),n.bondConfiguration.has(o)&&n.bondConfiguration.delete(o),n.kwargs.has(o)&&n.kwargs.delete(o),--o):(n.atomPairs[o][0]=t>e?t-1:t,n.atomPairs[o][1]=s>e?s-1:s),++o}let a=Array.from(n.bondConfiguration.keys());a.forEach((t=>{if(n.bondConfiguration.has(t)&&t>s){const e=n.bondConfiguration.get(t);n.bondConfiguration.delete(t),n.bondConfiguration.set(t-1,e)}})),a=Array.from(n.kwargs.keys()),a.forEach((t=>{if(n.kwargs.has(t)&&t>s){const e=n.kwargs.get(t);n.kwargs.delete(t),n.kwargs.set(t-1,e)}}))}}function C(t,e,s,i){const n=new t(e.length-i);let r=0,o=0;for(;r<e.length;)r===s&&(r+=i),n[o]=e[r],++o,++r;return n}function S(t,e){let s;if(0===t)s=e>0?0:Math.PI;else if(0===e)s=t>0?-Math.PI/2:Math.PI/2;else{const i=e/t,n=Math.atan(i);s=t<0?Math.PI/2+n:-Math.PI/2+n}return s}function M(t,e){if(0!==e){const s=t.x,i=t.y,n=Math.cos(e),r=Math.sin(e);for(let t=0;t<s.length;++t){const e=s[t];s[t]=d(e*n-i[t]*r),i[t]=d(e*r+i[t]*n)}}}function A(t,e){if(e){const e=t.atoms.y;for(let t=0;t<e.length;t++)e[t]=-e[t]}else{const e=t.atoms.x;for(let t=0;t<e.length;t++)e[t]=-e[t]}const s=t.bonds.bondConfiguration;for(const[t,e]of s){const i=1===e?3:1;s.set(t,i)}}function T(t,e,s){const i=t.atoms.x,n=t.atoms.y;for(let t=0;t<i.length;++t)i[t]=d(i[t]+e),void 0!==s&&(n[t]=d(n[t]+s))}},6137:(t,e,s)=>{"use strict";s.d(e,{J:()=>n});var i=s(9976);class n extends i.B{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new n({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class r{}r.SemType="Nucleotides",r.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",r.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},9976:(t,e,s)=>{"use strict";s.d(e,{B:()=>i});class i{static makePalette(t,e=!1,s=i){const n={};return t.forEach((t=>{const s=t[0],i=t[1];s.forEach(((t,s)=>{n[t]=this.colourPalette[i][e?0:s]}))})),new s(n)}constructor(t){this._palette=t}get(t){return this._palette[t]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},7331:(t,e,s)=>{"use strict";s.d(e,{UE:()=>h});var i=s(976),n=s(9976);class r{static hashCode(t){let e=0;if(0===t.length)return e;for(let s=0;s<t.length;s++)e=(e<<5)-e+t.charCodeAt(s),e|=0;return e}}class o{}class a extends o{get(t){return"#666666"}}class l extends o{static buildPalette(){return[].concat(...Object.values(n.B.colourPalette))}get(t){const e=r.hashCode(t)%l.palette.length;return function(t){if(null==t)return"rgb(100,100,100)";const e=i.Color.fromHtml(t),s=i.Color.g(e),n=i.Color.r(e),r=i.Color.b(e),o=Math.sqrt(Math.pow(0-n,2)+Math.pow(0-s,2)+Math.pow(0-r,2));return o>210?`rgb(${n/o*210},${s/o*210},${r/o*210})`:i.Color.toRgb(e)}(l.palette[e])}}l.palette=l.buildPalette();class h extends n.B{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new l),this.color}}},9611:(t,e,s)=>{"use strict";s.d(e,{A:()=>h});var i=s(4469),n=s(976),r=s(6414),o=s.n(r),a=s(8447);const l={DNA:"RNA",RNA:"RNA",PT:"PEPTIDE",UN:"PEPTIDE"};class h{get updated(){return this._updated}constructor(t,e,s){this.grid=t,this.col=e,this.propsProvider=s,this._monomerLengthList=null,this.separatorWidth=5,this._updated=!1,this._monomerLengthMap={},this._monomerStructureMap={},this.subs=[],this._splitter=(0,a.Mj)(this.col),this.props=this.propsProvider(),this._rowsProcessed=n.BitSet.create(this.col.length),this.grid&&(this.subs.push(e.dataFrame.onDataChanged.subscribe((()=>{this.props=this.propsProvider(),this._monomerLengthList=null,this._rowsProcessed=n.BitSet.create(this.col.length)}))),this.subs.push(i.events.onViewRemoved.subscribe((t=>{this.grid?.view?.id===t.id&&this.destroy()}))))}destroy(){for(const t of this.subs)t.unsubscribe()}getCellMonomerLengths(t){const e=this.props.unitsHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t),s=new Array(e.length+1);s[0]=5;for(let t=1;t<s.length;t++)s[t]=s[t-1]+e[t-1];return[e,s]}getCellMonomerLengthsForSeq(t){null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.col.length).fill(null),this._updated=!0);let e=this._monomerLengthList[t];if(null===e){const s=this.getSeqMonList(t);e=this._monomerLengthList[t]=new Array(s.length);for(const[t,i]of o().enumerate(s)){const s=this.props.monomerToShort(t,this.props.monomerLengthLimit),n=(this.props.unitsHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.monomerCharWidth;e[i]=n}this._updated=!0}return e}getCellMonomerLengthsForSeqMsa(){var t;null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null),this._updated=!0),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],s=Math.max(Math.floor((this.grid?.vertScroll.min??0)-10),0),i=Math.min(Math.ceil((this.grid?.vertScroll.max??0)+10),this.col.length);for(let t=s;t<i;t++){if(this._rowsProcessed.get(t))continue;const s=this.getSeqMonList(t);s.length>e.length&&e.push(...new Array(s.length-e.length).fill(0));for(const[t,i]of o().enumerate(s)){const s=this.props.monomerToShort(t,this.props.monomerLengthLimit),n=this.props.separatorWidth+s.length*this.props.monomerCharWidth;e[i]=Math.max(e[i]??0,n)}this._updated=!0}return e}getPosition(t,e){const[s,i]=this.getCellMonomerLengths(t),n=this.col.get(t);let r=100,a=null,l=o()(this._splitter(n)).toArray().length,h=!1,c=0;if(i[0]<=e&&e<i.slice(-1)[0])for(;!h;)if(c=Math.floor((l+(a??0))/2),e>=i[c]&&e<=i[c+1]?(a=c,h=!0):e<i[c]?l=c-1:e>i[c+1]&&(a=c+1),a==l&&(h=!0),--r<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(i)}. `);return a}getSeqMonList(t){const e=this.col.get(t);return e?o()(this._splitter(e)).toArray():[]}getMonomer(t){const e=this.props.unitsHandler.alphabet??"UN",s=l[e];return this.props.monomerLib?.getMonomer(s,t)??null}setMonomerLengthLimit(t){this.props.monomerLengthLimit=t,this._updated=!0}setSeparatorWidth(t){this.props.separatorWidth=t,this._updated=!0}isMsa(){return this.props.unitsHandler.isMsa()}}},1047:(t,e,s)=>{"use strict";s.d(e,{At:()=>n,K4:()=>r,rx:()=>i});const i=["symbol","molfile","rgroups","name"],n="MonomerName",r={monomerType:null,smiles:null,name:"MonomerName",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerCode"}},5226:(t,e,s)=>{"use strict";s.d(e,{i:()=>o});var i=s(976),n=s(499),r=s(1821);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,s=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==s&&this._sequencesArray.push(this.parseMacromolecule(s,e.index)),s=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(s,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.setTag(i.TAGS.UNITS,r.r2.FASTA),n.Cn.getOrCreate(e),[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},1821:(t,e,s)=>{"use strict";s.d(e,{BM:()=>r,XS:()=>a,r2:()=>i});var i,n=s(6286);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm"}(i||(i={}));const r=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,o=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},a=[new n.L("PT",o.fasta.peptide,.5),new n.L("DNA",o.fasta.dna,.55),new n.L("RNA",o.fasta.rna,.55)]},8447:(t,e,s)=>{"use strict";s.d(e,{GU:()=>n.GU,Mj:()=>n.Mj,dQ:()=>n.dQ,kB:()=>n.kB,py:()=>n.py,r2:()=>i.r2,up:()=>n.up});var i=s(1821),n=s(6066)},6286:(t,e,s)=>{"use strict";s.d(e,{L:()=>i,d:()=>n});class i{constructor(t,e,s){this.name=t,this.alphabet=e,this.cutoff=s}}class n extends i{constructor(t,e,s){super(t.name,t.alphabet,t.cutoff),this.freq=e,this.similarity=s}}},6066:(t,e,s)=>{"use strict";s.d(e,{w4:()=>A,py:()=>E,vU:()=>v,Mj:()=>C,Ar:()=>f,GU:()=>M,dQ:()=>T,up:()=>x,kB:()=>p,FJ:()=>g,gP:()=>b});var i=s(976),n=s(6414),r=s.n(n),o=s(6286),a=s(1821),l=s(499);class h extends Float32Array{}var c=s(7997),u=s(2012),m=s(6137),d=s(7331);function p(t){return r()(t.toString().matchAll(a.BM)).map((t=>t[2]??t[1])).toArray()}function g(t){return t||[]}function f(t,e=undefined){return s=>s.split(t,e)}const y=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,w=/\[([^\[\]]+)]/g;function b(t){y.lastIndex=0;const e=y.exec(t.toString()),s=e?e[2]:null;return(s?s.split("."):[]).map((t=>{w.lastIndex=0;const e=w.exec(t);return e&&e.length>=2?e[1]:t}))}function v(t,e,s=undefined){if(t.toLowerCase().startsWith(a.r2.FASTA))return p;if(t.toLowerCase().startsWith(a.r2.SEPARATOR))return f(e,s);if(t.toLowerCase().startsWith(a.r2.HELM))return b;throw new Error(`Unexpected units ${t} .`)}function C(t){return l.Cn.getOrCreate(t).getSplitter()}const S=/([^\W_]+)/g;function M(t,e){if(t.length<=e)return t;const s=t.match(S),i=t.length>e||(s?.length??0)>1,n=s?.[0]??" ";return i?n.substring(0,e-1)+"…":n}function A(t,e,s="-"){const i=e.map((e=>{const i=function(t,e,s="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(s);const n=[],r=[];for(const s of i)n.push(s in t?t[s]:0),r.push(e.has(s)?1:0);const o=new h(n),a=new h(r);return(0,c.MA)(o,a)/((0,c.$G)(o)*(0,c.$G)(a))}(t,e.alphabet,s);return new o.d(e,t,i)}));let n;const r=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return n=r>0?i.find((t=>t.similarity===r)).name:"UN",n}function T(t,e=5){let s;if(t.semType==i.SEMTYPE.MACROMOLECULE)s=l.Cn.getOrCreate(t).alphabet;else{const i=function(t,e,s){return t.categories,function(t,e){const s={};let i=!0,n=null;for(const r of t)if(null==n?n=r.length:r.length!==n&&(i=!1),r.length>=e)for(const t of r)t in s||(s[t]=0),s[t]+=1;return{freq:s,sameLength:i}}(r()(t.getRawData()).map((e=>s(t.categories[e]))),e)}(t,e,p);s=A(i.freq,a.XS)}return E(s)}function E(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return m.J.Chromatogram;default:return d.UE.Color}}function x(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},7767:(t,e,s)=>{"use strict";s.d(e,{L:()=>l});var i=s(6414),n=s.n(i),r=s(499),o=s(1821),a=s(6066);class l extends r.Cn{get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===o.r2.FASTA}toSeparator(t){return t===o.r2.SEPARATOR}toHelm(t){return t===o.r2.HELM}convertHelmToFastaSeparator(t,e,s,i){i||(i=this.toFasta(e)?r._9[o.r2.FASTA]:r._9[o.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const n=/(R\(|D\(|\)|P)/g,a=t.startsWith("DNA")||t.startsWith("RNA"),l=this.splitter(t),h=[];for(let t=0;t<l.length;t++){let s=l[t];if(a&&(s=s.replace(n,"")),s===r._9[o.r2.HELM])h.push(i);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";h.push(t)}else h.push(s)}return h.join(s)}convert(t,e){const s=this.getConverter(t,e),i=this.getNewColumn(t,e);return i.init((t=>s(this.column.get(t)))),i}constructor(t){super(t),this._splitter=null}getConverter(t,e=null){if(t===o.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const s=this;if(t===o.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?c(t,e):t.getSplitter()(e),i=new Array(s.length);for(const[e,a]of n().enumerate(s)){let n=e;t.isHelm()&&(n=e.replace(h,"$1")),t.isGap(n)?n=r._9[o.r2.FASTA]:n.length>1&&(n="["+s[a]+"]"),i[a]=n}return i.join("")}(s,t)};if(t===o.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA"),i=e.startsWith("RNA"),[a,l,c,u]=t.getHelmWrappers(),m=t.getSplitter()(e);return`${a}${n()(m).map((e=>{let n=e;return n=t.isGap(n)?r._9[o.r2.HELM]:s||i?n.replace(h,"$1"):1==e.length?`${l}${e}${c}`:`${l}[${e}]${c}`,n})).toArray().join(".")}${u}`}(s,t)};if(t===o.r2.SEPARATOR)return function(t){return function(t,e,s){const i=t.isHelm()?c(t,e):t.getSplitter()(e),a=new Array(i.length);e.startsWith("PEPTIDE");for(const[e,s]of n().enumerate(i)){let i=e;t.isGap(i)&&(i=r._9[o.r2.SEPARATOR]),a[s]=i}return a.filter((t=>null!==t)).join(s)}(s,t,e)};throw new Error}}const h=/[RD]\((\w)\)P?/g;function c(t,e){const s=t.getSplitter()(e),i=new Array(s.length),r=e.startsWith("DNA"),o=e.startsWith("RNA");for(const[t,e]of n().enumerate(s)){let s=t;(r||o)&&(s=s.replace(h,"$1"),s="P"===s?null:s),i[e]=s}return i.filter((t=>null!==t))}},8457:(t,e,s)=>{"use strict";s.d(e,{O:()=>a});var i=s(976),n=s(6414),r=s.n(n),o=s(6066);function a(t){const e=(0,o.Mj)(t),s=t=>{const e=l.columns.addNewString((t+1).toString());return n.push(e),e},n=[],a=t.length,l=i.DataFrame.create(a);for(let i=0;i<a;++i){const o=t.get(i);if(null==o)continue;const a=e(o);for(const[t,e]of r().enumerate(a))((n[e]??null)||s(e)).set(i,t||"-",!1)}return l}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>c,_9:()=>h});var i=s(976),n=s(1821),r=s(6066),o=s(489),a=s(7228);const l=new class{constructor(){this.uhTemp=`units-handler.${i.SEMTYPE.MACROMOLECULE}`}},h={[n.r2.FASTA]:"-",[n.r2.SEPARATOR]:"",[n.r2.HELM]:"*"};class c{static setUnitsToFastaColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==n.r2.FASTA)throw new Error(`The column of notation '${n.r2.FASTA}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(i.TAGS.UNITS,n.r2.FASTA),c.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==n.r2.SEPARATOR)throw new Error(`The column of notation '${n.r2.SEPARATOR}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${n.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(i.TAGS.UNITS,n.r2.SEPARATOR),t.column.setTag("separator",e),c.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${n.r2.HELM}' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(i.TAGS.UNITS,n.r2.HELM),c.setTags(t)}static setTags(t){const e=t.column.getTag(i.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[n.r2.FASTA,n.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");const e=s.sameLength?"SEQ.MSA":"SEQ";t.column.setTag("aligned",e);const i=(0,r.w4)(s.freq,n.XS);if(t.column.setTag("alphabet",i),"UN"===i){const e=Object.keys(s.freq).length,i=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",i?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===n.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==n.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===n.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),i=this._column.categories;for(let n=0;n<e;n++){const e=i[s[n]];this._splitted[n]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const i of this.splitted){null==s?s=i.length:i.length!==s&&(e=!1);for(const e of i)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}isFasta(){return this.notation===n.r2.FASTA}isSeparator(){return this.notation===n.r2.SEPARATOR}isHelm(){return this.notation===n.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===n.r2.FASTA&&t===h[n.r2.FASTA]||this.units===n.r2.HELM&&t===h[n.r2.HELM]}getNotation(){if(this.units.toLowerCase().startsWith(n.r2.FASTA))return n.r2.FASTA;if(this.units.toLowerCase().startsWith(n.r2.SEPARATOR))return n.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(n.r2.HELM))return n.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}getNewColumn(t,e){const s=this.column,r=s.length,o=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(o),l=i.Column.fromList("string",a,new Array(r).fill(""));if(l.semType=i.SEMTYPE.MACROMOLECULE,l.setTag(i.TAGS.UNITS,t),t===n.r2.SEPARATOR){if(!e)throw new Error(`Notation '${n.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");null!=c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");null!=c&&u&&l.setTag(".alphabetSize",u);const m=s.getTag(".alphabetIsMultichar");return null!=c&&void 0!==m&&l.setTag(".alphabetIsMultichar",m),t==n.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=c.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[n.r2.FASTA,n.r2.SEPARATOR,n.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!c.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const n=i.Column.fromList("string",e,new Array(t).fill(""));return n.semType=i.SEMTYPE.MACROMOLECULE,n.setTag(i.TAGS.UNITS,s),n}getSplitter(t){if(this.units.toLowerCase().startsWith(n.r2.FASTA))return null===this.column.getTag("alphabet")||this.getAlphabetIsMultichar()?r.kB:r.FJ;if(this.units.toLowerCase().startsWith(n.r2.SEPARATOR))return(0,r.Ar)(this.separator,t);if(this.units.toLowerCase().startsWith(n.r2.HELM))return r.gP;throw new Error(`Unexpected units ${this.units} .`)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return o.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return o.U.LEVENSHTEIN;case"PT":return o.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return o.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,a.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,r.Ar)(this.separator);for(const t of this.column.categories){const i=s(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}constructor(t){if(this._splitted=null,this._stats=null,t.type!=i.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${i.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?h[n.r2.FASTA]:this.isHelm()?h[n.r2.HELM]:h[n.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())c.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");c.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(i.TAGS.UNITS)}'.`);c.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return l.uhTemp in t.temp||(t.temp[l.uhTemp]=new c(t)),t.temp[l.uhTemp]}}},9298:(t,e,s)=>{"use strict";var i,n,r,o,a,l;s.d(e,{CI:()=>c,Ct:()=>l,DX:()=>i,ES:()=>n,dE:()=>a,iD:()=>o,vS:()=>h,vw:()=>r}),function(t){t.positionNames=".wl.positionNames",t.positionLabels=".wl.positionLabels",t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(n||(n={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(r||(r={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(o||(o={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=n.full,this.positionWidth=16,this.verticalAlignment=r.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}},c=", "},2669:(t,e,s)=>{"use strict";s.d(e,{m:()=>i});class i{constructor(t=!0,e=!0){const i=navigator.hardwareConcurrency;this._workerCount=t?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(18),s.b)))),this._terminateOnComplete=e}async calc(t,e,s=!0){return new Promise((async(i,n)=>{try{const n=t.length,r=new Array(this._workerCount),o=n*(n-1)/2;this._workerCount=Math.min(this._workerCount,o);const a=o/this._workerCount,l=new Float32Array(o);let h=0,c=1,u=0,m=Number.MIN_VALUE;for(let s=0;s<this._workerCount;s++){const i=Math.floor(s*a),d=s===this._workerCount-1?o:Math.floor((s+1)*a),p=h,g=c;s!==this._workerCount-1&&(h=n-2-Math.floor(Math.sqrt(-8*d+4*n*(n-1)-7)/2-.5),c=d-n*h+Math.floor((h+1)*(h+2)/2)),this._workers[s].postMessage({values:t,fnName:e,startRow:p,startCol:g,chunckSize:d-i}),r[s]=new Promise(((t,e)=>{this._workers[s].onmessage=({data:{error:n,distanceMatrixData:r,min:o,max:a}})=>{this._terminateOnComplete&&this._workers[s].terminate(),n?e(n):(l.set(r,i),o<u&&(u=o),a>m&&(m=a),t())}}))}await Promise.all(r),s&&l.forEach(((t,e)=>{l[e]=(t-u)/(m-u)})),i(l)}catch(t){n(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}},3914:(t,e,s)=>{"use strict";s.d(e,{H:()=>n});var i=s(6814);class n{get data(){return this._data}get size(){return this._size}constructor(t,e){if(null==e){if(null==t)throw new Error("Arguments error: data or size is required.");if(this._data=t,this._size=(1+Math.sqrt(1+8*this._data.length))/2,this._size!=Math.floor(this._size))throw new Error(`Invalid data length ${this._data.length} leads to non integer size ${this._size}`)}else{this._size=e;const s=e*(e-1)/2;if(t){if(t.length!=s)throw new Error(`Invalid data length. Observations size ${e} requires data length ${s}.`);this._data=t}else this._data=new Float32Array(s)}}_linearizeIJ(t,e){if(!(t<e))throw new Error("i must be less than j");return this._size*t+e-Math.floor((t+2)*(t+1)/2)}get(t,e){return t==e?0:t<e?this._data[this._linearizeIJ(t,e)]:this._data[this._linearizeIJ(e,t)]}set(t,e,s){this._data[this._linearizeIJ(t,e)]=s}static calc(t,e){const s=t.length,r=new n(void 0,s);for(let n=0;n<s;n++)for(let o=n+1;o<s;o++)r.set(n,o,(0,i.k)(t[n])||(0,i.k)(t[o])?1:e(t[n],t[o]));return r}square(){for(let t=0;t<this._data.length;t++)this._data[t]=this._data[t]**2}add(t){if(this._size!==t._size)throw new Error(`Matrices must have the same size. This size: ${this._size}, other size: ${t._size}`);for(let e=0;e<this._data.length;e++)this._data[e]+=t._data[e]}sqrt(){for(let t=0;t<this._data.length;t++)this._data[t]=Math.sqrt(this._data[t])}normalize(){let t=0,e=this._data[0];for(let s=0;s<this._data.length;s++)this._data[s]<t&&(t=this._data[s]),this._data[s]>e&&(e=this._data[s]);const s=e-t;for(let i=0;i<this._data.length;i++)this._data[i]=0===s?this._data[i]-t:(this._data[i]-t)/(e-t)}}},6254:(t,e,s)=>{"use strict";function i(t,e){const s=n(e);function i(t,e){const i=Number(t),n=Number(e);return s(i,n)}const r={get:(t,s,n)=>"length"===s?e:new Proxy(t,function(t){return{get:(e,s,n)=>t===s?0:e[Number(t)>Number(s)?i(s,t):i(t,s)]}}(s))};return new Proxy(t,r)}function n(t){return(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2)}s.d(e,{_:()=>i,y:()=>n})},6814:(t,e,s)=>{"use strict";s.d(e,{k:()=>i});const i=t=>null==t},5697:(t,e,s)=>{"use strict";s.d(e,{Dz:()=>g,KR:()=>o,MI:()=>y,NB:()=>u,Om:()=>w,Rt:()=>r,UX:()=>c,WI:()=>h,Zd:()=>l,_h:()=>a,aW:()=>d,bX:()=>v,fX:()=>f,kg:()=>n,s:()=>m,yU:()=>p});var i=s(1040);i.gk.Tanimoto,i.gk.Dice,i.gk.Asymmetric,i.gk.BraunBlanquet,i.gk.Cosine,i.gk.Kulczynski,i.gk.McConnaughey,i.gk.RogotGoldberg,i.gk.Russel,i.gk.Sokal,i.gk.Hamming,i.gk.Euclidean,i.gk.Tanimoto,i.gk.Dice,i.gk.Asymmetric,i.gk.BraunBlanquet,i.gk.Cosine,i.gk.Kulczynski,i.gk.McConnaughey,i.gk.RogotGoldberg,i.gk.Russel,i.gk.Sokal,i.gk.Hamming,i.gk.Euclidean;const n=[i.gk.Tanimoto,i.gk.Dice,i.gk.Cosine],r=[i.gk.Tanimoto,i.gk.Asymmetric,i.gk.Cosine,i.gk.Sokal];function o(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount();if(0==s)return 1;const i=t.andWithCountBits(e,!0);return i/(s-i)}(t,e))}function a(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount();return 0==s?0:2*t.andWithCountBits(e,!0)/s}(t,e))}function l(t,e){return b(function(t,e){const s=t.trueCount()*e.trueCount();return 0==s?0:t.andWithCountBits(e,!0)/Math.sqrt(s)}(t,e))}function h(t,e){return Math.sqrt(t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0))}function c(t,e){return t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0)}function u(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount(),i=t.andWithCountBits(e,!0);return i/(2*s-3*i)}(t,e))}function m(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:t.andWithCountBits(e,!0)*s/(2*i)}(t,e))}function d(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:(t.andWithCountBits(e,!0)*s-i)/i}(t,e))}function p(t,e){return b(function(t,e){const s=Math.min(t.trueCount(),e.trueCount());return 0==s?0:t.andWithCountBits(e,!0)/s}(t,e))}function g(t,e){return b(function(t,e){const s=Math.max(t.trueCount(),e.trueCount());return 0==s?0:t.andWithCountBits(e,!0)/s}(t,e))}function f(t,e){return b(function(t,e){return 0==t.length?0:t.andWithCountBits(e,!0)/t.length}(t,e))}function y(t,e){return b(function(t,e){const s=t.andWithCountBits(e,!0),i=t.countBits(!0)+e.countBits(!0),n=t.length,r=n-i+s;return s==n||r==n?1:s/i+r/(2*n-i)}(t,e))}function w(t){return 1/(1+t)}function b(t){return 1/t-1}function v(t,e){return Math.abs(t-e)}},779:(t,e,s)=>{"use strict";function i(){return(t,e)=>{let s=0;t.length!==e.length&&(s=Math.abs(t.length-e.length));let i=0;for(let s=0;s<Math.min(t.length,e.length);s++)t[s]!==e[s]&&i++;return i+=s,i/=Math.max(t.length,e.length),i}}s.d(e,{j:()=>i})},489:(t,e,s)=>{"use strict";s.d(e,{U:()=>i.U,o:()=>i.o});var i=s(5540)},458:(t,e,s)=>{"use strict";s.d(e,{r:()=>n});var i=s(1811);function n(){return(t,e)=>(0,i.T)(t,e)/Math.max(t.length,e.length)}},5540:(t,e,s)=>{"use strict";s.d(e,{U:()=>i,o:()=>a});var i,n=s(779),r=s(458),o=s(6683);!function(t){t.HAMMING="Hamming",t.LEVENSHTEIN="Levenshtein",t.NEEDLEMANN_WUNSCH="Needlemann-Wunsch"}(i||(i={}));const a={[i.HAMMING]:n.j,[i.LEVENSHTEIN]:r.r,[i.NEEDLEMANN_WUNSCH]:o.n}},6683:(t,e,s)=>{"use strict";s.d(e,{n:()=>n});const i={gapOpen:8,gapExtend:2,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};function n(t){return(e,s)=>{const{gapOpen:n,gapExtend:r,scoringMatrix:o,alphabetIndexes:a}={...i,...t},l=[new Array(e.length+1).fill(0),new Array(e.length+1).fill(0)],h=new Array(e.length+1).fill(!1),c=new Array(e.length+1).fill(!1);let u=0,m=1;for(let t=1;t<e.length+1;t++)l[0][t]=-n-(t-1)*r;for(let t=1;t<s.length+1;t++){l[m][0]=-n-(t-1)*r;for(let i=1;i<e.length+1;i++){const d=l[u][i-1]+o[a[e[i-1]]][a[s[t-1]]],p=l[u][i]-(h[i]?r:n),g=l[m][i-1]-(c[i-1]?r:n);l[m][i]=Math.max(d,g,p),l[m][i]===d?(h[i]=!1,c[i]=!1):l[m][i]===g?(h[i]=!1,c[i]=!0):(h[i]=!0,c[i]=!1)}u=m,m=(m+1)%2}const d=e.split("").map((t=>o[a[t]][a[t]])).reduce(((t,e)=>t+e),0),p=s.split("").map((t=>o[a[t]][a[t]])).reduce(((t,e)=>t+e),0),g=Math.max(d,p);return(g-l[u][e.length])/g}}},116:(t,e,s)=>{"use strict";var i;s.d(e,{AL:()=>i,aP:()=>r,bD:()=>n}),s(4221),s(7659),s(3659),s(850),s(9006),s(7861),s(9657),s(2669),s(3914),s(6254),function(t){t.UMAP="UMAP",t.T_SNE="t-SNE"}(i||(i={}));class n{constructor(){this.learningRate={uiName:"Learinig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nComponents={uiName:"Components",value:2,tooltip:"The number of components (dimensions) to project the data to"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, used with spread to control the clumped/dispersed nature of the embedding"}}}class r{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"},this.dim={uiName:"Dimensionality",value:2,tooltip:"Dimensionality of the embedding"}}}},7656:(t,e,s)=>{"use strict";s.d(e,{I:()=>n});var i=s(850);async function n(t,e,n,r,o){const a=await async function(t,e,i,n){return new Promise((function(r,o){const a=new Worker(new URL(s.p+s.u(729),s.b));a.postMessage({columnData:t.data,method:e,measure:t.metric,options:i,parallelDistanceWorkers:n}),a.onmessage=({data:{error:t,distance:e,embedding:s}})=>{t?o(t):r({distance:e,embedding:s}),setTimeout((()=>a.terminate()),0)}}))}({data:t,metric:n},e,r,o);return a.embedding=a.embedding.map((t=>(0,i.Fv)(t))),a}},9006:(t,e,s)=>{"use strict";s.d(e,{Ek:()=>l,a1:()=>a,nR:()=>h});var i=s(850),n=s(4588),r=s(6254),o=s(2669);class a{constructor(t){this.steps=t?.steps??0,this.cycles=t?.cycles??1e6,this.cutoff=t?.cutoff??0,this.lambda=t?.lambda??2,this.dlambda=t?.dlambda??.01,this.lambda2=this.lambda/2,this.dlambda2=this.dlambda/2,this.epsilon=t?.epsilon??1e-10,this.distanceFunction=t?.distance??i.dP,this.distance=new Float32Array,this.distanceFunctionName=t?.distanceFunctionName}async initDistance(t){this.dmIndexFunct=(0,r.y)(t.length);const e=new o.m(!0,!1);this.distance=await e.calc(t,this.distanceFunctionName),e.terminate()}calcDistance(t,e,s){return this.distance[this.dmIndexFunct(e,s)]}async embed(t){const e=t.length,s=(0,i.kO)(e,a.dimension,40);let r=this.lambda2;0===this.steps&&(this.steps=t.length-1),await this.initDistance(t);for(let o=0;o<this.cycles;++o){for(let o=0;o<this.steps;++o){const o=(0,n.I)(e);let a=(0,n.I)(e);for(;o==a;)a=(0,n.I)(e);const l=s[o],h=s[a],c=this.calcDistance(t,o,a),u=(0,i.dP)(l,h);if(0==this.cutoff||c<=this.cutoff||u<c){const t=r*(c-u)/(u+this.epsilon),e=(0,i.On)(l,h,-1);s[o]=(0,i.On)(l,e,t),s[a]=(0,i.On)(h,e,-t)}}if(r-=this.dlambda2,r<=0)break}return s}}a.dimension=2;class l extends a{async embed(t){const e=t.length,s=(0,i.kO)(e,l.dimension,40);let r=this.lambda;await this.initDistance(t);for(let o=0;o<this.cycles;++o){const o=(0,n.I)(e),a=s[o];for(let n=0;n<e;++n){if(o==n)continue;const e=s[n],l=this.calcDistance(t,o,n),h=(0,i.dP)(a,e);if(0==this.cutoff||l<=this.cutoff||h<l){const t=r*(l-h)/(h+this.epsilon),o=(0,i.On)(a,e,-1);s[n]=(0,i.On)(e,o,-t)}}if(r-=this.dlambda,r<=0)break}return s}}class h extends a{constructor(t){super(t),this.cycles=t?.cycles??1e3,this.steps=t?.steps??1e5,this.radiusPercent=t?.radiusPercent??1,this.maxDistance=t?.maxDistance??null,this.maxDistanceSteps=t?.maxDistanceSteps??null}async embed(t){const e=t.length,s=(0,i.kO)(e,h.dimension,40);if(await this.initDistance(t),null===this.maxDistanceSteps&&(this.maxDistanceSteps=e*Math.floor((e-1)/2)),null===this.maxDistance){this.maxDistance=-1e37;for(let s=0;s<this.maxDistanceSteps;s++){const s=(0,n.I)(e);let i=(0,n.I)(e);for(;s==i;)i=(0,n.I)(e);const r=this.calcDistance(t,s,i);r>this.maxDistance&&(this.maxDistance=r)}}let r=this.lambda;const o=0==this.radiusPercent?this.maxDistance:this.maxDistance*this.radiusPercent;for(let a=0;a<this.cycles;++a){for(let a=0;a<this.steps;++a){const a=(0,n.I)(e);let l=(0,n.I)(e);for(;a==l;)l=(0,n.I)(e);const h=s[a],c=s[l],u=this.calcDistance(t,a,l),m=(0,i.dP)(h,c);if(u<=o||m<u){const t=.5*r*(u-m)/(m+this.epsilon),e=(0,i.On)(h,c,-1);s[a]=(0,i.On)(h,e,t),s[l]=(0,i.On)(c,e,-t)}}if(r-=(this.lambda-this.dlambda)/(this.cycles-1),r<this.dlambda)break}return s}}},1040:(t,e,s)=>{"use strict";var i,n,r,o,a;s.d(e,{CF:()=>n,Qe:()=>o,W:()=>i,Yc:()=>a,gk:()=>r}),function(t){t.Levenshtein="Levenshtein",t.JaroWinkler="Jaro-Winkler",t.Manhattan="Manhattan"}(i||(i={})),function(t){t.Euclidean="Euclidean"}(n||(n={})),function(t){t.Tanimoto="Tanimoto",t.Dice="Dice",t.Asymmetric="Asymmetric",t.BraunBlanquet="Braun-Blanquet",t.Cosine="Cosine",t.Kulczynski="Kulczynski",t.McConnaughey="Mc-Connaughey",t.RogotGoldberg="Rogot-Goldberg",t.Russel="Russel",t.Sokal="Sokal",t.Hamming="Hamming",t.Euclidean="Euclidean"}(r||(r={})),function(t){t.Vector="Vector",t.String="String",t.BitArray="BitArray",t.MacroMolecule="MacroMolecule",t.Number="Number"}(o||(o={})),function(t){t.NumericDistance="NumericDistance"}(a||(a={}))},7861:(t,e,s)=>{"use strict";var i=s(1811),n=s(3979),r=s(5697),o=s(850),a=s(489),l=s(1040);const h={[l.CF.Euclidean]:o.dP},c={[l.W.Levenshtein]:i.T,[l.W.JaroWinkler]:n.H$,[l.W.Manhattan]:function(t,e){if(t.length!==e.length)return 1;{let s=0;for(let i=1;i<t.length;i++)s+=t[i]==e[i]?0:1;return s/t.length}}},u={[l.gk.Tanimoto]:r.KR,[l.gk.Dice]:r._h,[l.gk.Asymmetric]:r.yU,[l.gk.BraunBlanquet]:r.Dz,[l.gk.Cosine]:r.Zd,[l.gk.Kulczynski]:r.s,[l.gk.McConnaughey]:r.aW,[l.gk.RogotGoldberg]:r.MI,[l.gk.Russel]:r.fX,[l.gk.Sokal]:r.NB,[l.gk.Hamming]:r.UX,[l.gk.Euclidean]:r.WI},m={[l.Yc.NumericDistance]:r.bX},d={[l.Qe.Vector]:{[l.CF.Euclidean]:h[l.CF.Euclidean]},[l.Qe.String]:{[l.W.Levenshtein]:c[l.W.Levenshtein],[l.W.JaroWinkler]:c[l.W.JaroWinkler],[l.W.Manhattan]:c[l.W.Manhattan]},[l.Qe.BitArray]:{[l.gk.Tanimoto]:u[l.gk.Tanimoto],[l.gk.Dice]:u[l.gk.Dice],[l.gk.Asymmetric]:u[l.gk.Asymmetric],[l.gk.BraunBlanquet]:u[l.gk.BraunBlanquet],[l.gk.Cosine]:u[l.gk.Cosine],[l.gk.Kulczynski]:u[l.gk.Kulczynski],[l.gk.McConnaughey]:u[l.gk.McConnaughey],[l.gk.RogotGoldberg]:u[l.gk.RogotGoldberg],[l.gk.Russel]:u[l.gk.Russel],[l.gk.Sokal]:u[l.gk.Sokal]},[l.Qe.MacroMolecule]:{[a.U.HAMMING]:a.o[a.U.HAMMING],[a.U.LEVENSHTEIN]:a.o[a.U.LEVENSHTEIN],[a.U.NEEDLEMANN_WUNSCH]:a.o[a.U.NEEDLEMANN_WUNSCH]},[l.Qe.Number]:{[l.Yc.NumericDistance]:m[l.Yc.NumericDistance]}};Object.keys(d).reduce(((t,e)=>{for(const s of Object.keys(d[e]))t[s]=e;return t}),{})},9657:(t,e,s)=>{"use strict";class i{constructor(t,e=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof t){const s=t,n=i._createBuffer(s);if(e)for(let t=0;t<n.length;t++)n[t]=-1;this._data=n,this._length=s}else{if(!(t instanceof Uint32Array))throw new Error("Invalid constructor");this._data=t,this._length=e}}getRawData(){return this._data}assureGoez(t,e){if(t<0)throw new Error(`${e} should be greater than zero`)}assureInRange(t,e,s,i){if(t<e||t>s)throw new Error(`Argument ${i} (${t}) out of range (${e}, ${s})`)}copy(t,e,s){for(let i=0;i<s;i++)e[i]=t[i]}copyFrom(t){if(this._length!=t._length)throw new Error(`Lengths differ (${this._length} != ${t._length})`);this.copy(t._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(t){this._data=t,this._version++}get version(){return this._version}set version(t){this._version=t}incrementVersion(t=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(t){this._versionedName=t,this._versionedNameVersion=this._version}get self(){return this}setLength(t){if(t<0)throw new Error("should be >= 0");if(t==this._length)return;const e=Math.floor((t+31)/32);if(e>this._data.length||e+this.SHRINK_THRESHOLD<this._data.length){const t=new Uint32Array(e);this.copy(this._data,t,e>this._data.length?this._data.length:e),this._data=t}t>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,e)),this._length=t,this._version++}static fromAnd(t,e){if(t._length!=e._length)throw new Error(`Lengths differ (${t._length} != ${e._length})`);const s=new i(t._length);s._length=t._length,s._data=i._createBuffer(s._length),s._version=0;const n=t.lengthInInts;for(let i=0;i<n;i++)s._data[i]=t._data[i]&e._data[i];return s}static _createBuffer(t){return new Uint32Array(Math.floor((t+31)/32))}static fromValues(t){const e=new i(t.length);e._version=0;for(let s=0;s<e._length;s++)t[s]&&(e._data[Math.floor(s/32)]|=1<<(s%32&31));return e}static fromSeq(t,e){const s=new i(t);for(let i=0;i<t;++i)s.setBit(i,e(i));return s._version=0,s}static fromString(t){return i.fromSeq(t.length,(e=>"1"==t.charAt(e)))}static fromUint32Array(t,e){const s=new i(t);return s._data=e,s}static fromBytes(t){const e=t.length,s=new i(8*e);s._data=new Uint32Array(Math.floor((e+3)/4)),s._length=8*e;let n=0,r=0;for(;e-r>=4;)s._data[n++]=255&t[r]|(255&t[r+1])<<8|(255&t[r+2])<<16|(255&t[r+3])<<24,r+=4;return e-r==3&&(s._data[n]=(255&t[r+2])<<16),e-r==2&&(s._data[n]|=(255&t[r+1])<<8),e-r==1&&(s._data[n]|=255&t[r]),s._version=0,s}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(t){if(this==t)return!0;if(null==t)return!1;if(this._length!=t._length)return!1;if(0==this._length)return!0;for(let e=0;e<this._data.length-1;e++)if(this._data[e]!=t._data[e])return!1;for(let e=8*(this._data.length-1);e<this._length;e++)if(this.getBit(e)!=t.getBit(e))return!1;return!0}clone(){const t=new i(0,!1);return t._data=Uint32Array.from(this._data),t._length=this._length,t._version=this._version,t}init(t,e){this.setAll(!1,!1);for(let e=0;e<this._length;e++)t(e)&&(this._data[Math.floor(e/32)]|=1<<(e%32&31));return this.incrementVersion(e),this}invert(t=!0){for(let t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const s=t?-1:0,i=this.lengthInInts;for(let t=0;t<i;t++)this._data[t]=s;this.incrementVersion(e)}setIndexes(t,e=!0,s=!0,i=!0){s&&this.setAll(!e,!1);for(const s of t)this.setFast(s,e);this.incrementVersion(i)}everyIndex(t,e=!0){for(const s of t)if(this.getBit(s)!=e)return!1;return!0}anyIndex(t,e=!0){for(const s of t)if(this.getBit(s)==e)return!0;return!1}setWhere(t,e=!0,s=!0,i=!0,n=!0){if(s&&n&&this.setAll(!e,!1),n)for(let s=0;s<this._length;s++)t(s)&&this.setFast(s,e);else for(let s=0;s<this._length;s++)this.setFast(s,t(s)?e:!e);this.incrementVersion(i)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const s=[];for(let i=t;i<e;++i)s.push(this.getBit(i));return i.fromValues(s)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const s=[];for(let i=t;i<e;++i)s.push(this.getBit(i));return s}setRange(t,e,s,i=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const n=Math.min(t,e),r=Math.max(t,e);if(s)for(let t=n;t<=r;t++)this.setTrue(t);else for(let t=n;t<=r;t++)this.setFalse(t);return this.incrementVersion(i),this}setRandom(t,e,s=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let s=0;s<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),s++)}this.incrementVersion(s)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const s=this.lengthInInts;for(let e=0;e<s;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]|=t._data[e];return this.incrementVersion(e),this}xor(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]^=t._data[e];return this.incrementVersion(e),this}insertAt(t,e,s=!1){if(this.assureInRange(t,0,this._length,"pos"),0==e)return;const i=this._length;this.setLength(this._length+e);for(let s=i-1;s>=t;s--)this.setBit(s+e,this.getBit(s));for(let i=t;i<t+e;i++)this.setBit(i,s)}removeAt(t,e=1){if(e<0)throw new Error("n cannot be negative");if(this.assureInRange(t,0,this._length-e,"pos"),this.contains(!0))for(let s=t;s<this._length-e;s++)this.setBit(s,this.getBit(s+e));this.setLength(this._length-e)}removeByMask(t,e=!0){if(this._length!=t.length)throw new Error("length != mask.length");if(t==this)this.setLength(t.countBits(!e)),this.setAll(!e);else{let s=0;for(let i=-1;-1!=(i=t.findNext(i,!e));)this.setFast(s++,this.getBit(i));this._length=s,this._version++}return this}getBit(t){return 0!=(this._data[Math.floor(t/32)]&1<<(31&t))}setBit(t,e,s=!0){this.setFast(t,e),this._version++}setFast(t,e){e?this._data[Math.floor(t/32)]|=1<<(31&t):this._data[Math.floor(t/32)]&=~(1<<(31&t))}setTrue(t){this._data[Math.floor(t/32)]|=1<<(31&t)}setFalse(t){this._data[Math.floor(t/32)]&=~(1<<(31&t))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(t){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const t=this.lengthInInts;let e=0;for(;e<t-1;e++)for(let t=this._data[e];0!=t;t>>>=8)this._selectedCount+=i._onBitCount[255&t];let s=this._data[e];const n=31&this._length;for(0!=n&&(s&=~(4294967295<<n));0!=s;s>>>=8)this._selectedCount+=i._onBitCount[255&s];this._selectedCountVersion=this._version}return t?this._selectedCount:this._length-this._selectedCount}countWhere(t){let e=0;if(this.trueCount()==this._length)for(let s=0;s<this._length;s++)e+=t(s)?1:0;else for(let s=-1;-1!=(s=this.findNext(s,!0));)e+=t(s)?1:0;return e}andWithCountBits(t,e){if(0==this._length)return 0;let s=0;const n=this.lengthInInts;let r=0;for(;r<n-1;r++)for(let e=this._data[r]&t._data[r];0!=e;e>>>=8)s+=i._onBitCount[255&e];let o=this._data[r]&t._data[r];const a=31&this._length;for(0!=a&&(o&=~(4294967295<<a));0!=o;o>>>=8)s+=i._onBitCount[255&o];return e?s:this._length-s}clear(){this.setLength(0)}contains(t){return this.findNext(-1,t)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(t,e=!0){if(this.assureInRange(t,-1,this._length,"index"),t>=this._length-1)return-1;let s=31&(t=t<0?0:t+1);const n=this.lengthInInts;for(let r=Math.floor(t/32);r<n;r++){let n=e?this._data[r]:~this._data[r];if(0!=s)n&=4294967295<<s&4294967295,s=0;else if(!e&&-4294967296==n)continue;for(let e=0;0!=n;e+=8,n>>>=8){const s=i._firstOnBit[255&n];if(s>=0)return(t=s+32*r+e)>=this._length?-1:t}}return-1}findPrev(t,e=!0){if(0==t)return-1;this.assureInRange(t,-1,this._length,"index");let s=1+(t=t<0?this._length-1:t-1)&31;for(let n=Math.floor(t/32);n>=0;n--){let t=e?this._data[n]:~this._data[n];0!=s&&(t&=~(4294967295<<s),s=0);for(let e=24;0!=t;e-=8,t<<=8){const s=i._lastOnBit[t>>>24];if(s>=0)return s+32*n+e}}return-1}}i._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),i._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),i._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},4588:(t,e,s)=>{"use strict";function i(t){return Math.random()*t}function n(t){return Math.floor(i(t))}s.d(e,{I:()=>n,t:()=>i})},8518:(t,e,s)=>{"use strict";s.d(e,{L:()=>n});var i=s(4588);function n(t,e,s){function n(t,e){let s=null,i=null;for(const n of t){const t=e(n);(null==i||t>i)&&(s=n,i=t)}return s}const r=[(0,i.I)(t-1)],o=new Set;for(let e=0;e<t;++e)r.includes(e)||o.add(e);for(;r.length<e;){const t=n(o.values(),(t=>Math.min.apply(Math,r.map((function(e,i){return s(t,e)})))));null!=t&&(r.push(t),o.delete(t))}return r}},1061:(t,e,s)=>{"use strict";s.d(e,{gw:()=>r}),s(4469),s(976);var i,n=function(t,e,s,i){return new(s||(s=Promise))((function(n,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?n(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};function r(t){return n(this,void 0,void 0,(function*(){yield new Promise((e=>setTimeout(e,t)))}))}!function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(i||(i={}))},3659:(t,e,s)=>{"use strict";s.d(e,{OW:()=>i});class i extends Float32Array{}},850:(t,e,s)=>{"use strict";s.d(e,{Fv:()=>h,On:()=>o,dP:()=>l,hu:()=>r,kO:()=>a});var i=s(3659),n=s(4588);function r(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function o(t,e,s=1){const n=t.length;r(n==e.length,"Vector lengths do not match.");const o=new i.OW(n);for(let i=0;i<t.length;++i)o[i]=t[i]+s*e[i];return o}function a(t,e,s=1){const r=function(t,e,s=0){return new Array(t).fill(s).map((()=>new i.OW(e).fill(s)))}(t,e);for(let i=0;i<t;++i)for(let t=0;t<e;++t)r[i][t]=(0,n.t)(s);return r}function l(t,e){const s=function(t){let e=0;for(let s=0;s<t.length;++s)e+=t[s];return e}(function(t){const e=t.length,s=new i.OW(e);for(let e=0;e<t.length;++e)s[e]=t[e]*t[e];return s}(o(t,e,-1)));return Math.sqrt(s)}function h(t){let e=0,s=0;for(let s=0;s<t.length;++s)e+=t[s];e/=t.length;for(let i=0;i<t.length;++i)s+=(t[i]-e)*(t[i]-e);s=Math.sqrt(s/t.length);for(let i=0;i<t.length;++i)t[i]=(t[i]-e)/s;return t}},7659:(t,e,s)=>{"use strict";e.Z=void 0;var i=s(6215);Object.defineProperty(e,"Z",{enumerable:!0,get:function(){return i.TSNE}})},6215:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.TSNE=void 0,e.TSNE=class{constructor(t){this.returnV=!1,this.vValue=0,this.iter=0,t=t||{},this.perplexity=this.getopt(t,"perplexity",30),this.dim=this.getopt(t,"dim",2),this.epsilon=this.getopt(t,"epsilon",10)}assert(t,e){if(!t)throw e||"Assertion failed"}getopt(t,e,s){return t.hasOwnProperty(e)?t[e]:s}gaussRandom(){if(this.returnV)return this.returnV=!1,this.vValue;const t=2*Math.random()-1,e=2*Math.random()-1,s=t*t+e*e;if(0===s||s>1)return this.gaussRandom();const i=Math.sqrt(-2*Math.log(s)/s);return this.vValue=e*i,this.returnV=!0,t*i}randn(t,e){return t+this.gaussRandom()*e}zeros(t){if(void 0===t||isNaN(t))return[];if("undefined"==typeof ArrayBuffer){const e=new Array(t);for(let s=0;s<t;s++)e[s]=0;return e}return new Float64Array(t)}randn2d(t,e,s){const i=void 0!==s,n=[];for(let r=0;r<t;r++){const t=[];for(let n=0;n<e;n++)i?t.push(s):t.push(this.randn(0,1e-4));n.push(t)}return n}L2(t,e){const s=t.length;let i=0;for(let n=0;n<s;n++){const s=t[n],r=e[n];i+=(s-r)*(s-r)}return i}xtod(t){const e=t.length,s=this.zeros(e*e);for(let i=0;i<e;i++)for(let n=i+1;n<e;n++){const r=this.L2(t[i],t[n]);s[i*e+n]=r,s[n*e+i]=r}return s}d2p(t,e,s){const i=Math.sqrt(t.length),n=Math.floor(i);this.assert(n===i,"D should have square number of elements.");const r=Math.log(e),o=this.zeros(n*n),a=this.zeros(n);for(let e=0;e<n;e++){let i=-1/0,l=1/0,h=1,c=!1;const u=50;let m=0;for(;!c;){let o=0;for(let s=0;s<n;s++){let i=Math.exp(-t[e*n+s]*h);e===s&&(i=0),a[s]=i,o+=i}let d=0;for(let t=0;t<n;t++){let e;e=0===o?0:a[t]/o,a[t]=e,e>1e-7&&(d-=e*Math.log(e))}d>r?(i=h,l===1/0?h*=2:h=(h+l)/2):(l=h,i===-1/0?h/=2:h=(h+i)/2),m++,Math.abs(d-r)<s&&(c=!0),m>=u&&(c=!0)}for(let t=0;t<n;t++)o[e*n+t]=a[t]}const l=this.zeros(n*n),h=2*n;for(let t=0;t<n;t++)for(let e=0;e<n;e++)l[t*n+e]=Math.max((o[t*n+e]+o[e*n+t])/h,1e-100);return l}sign(t){return t>0?1:t<0?-1:0}initDataRaw(t){const e=t.length,s=t[0].length;this.assert(e>0," X is empty? You must have some data!"),this.assert(s>0," X[0] is empty? Where is the data?");const i=this.xtod(t);this.P=this.d2p(i,this.perplexity,1e-4),this.N=e,this.initSolution()}initDataDist(t){const e=t.length;this.assert(e>0," X is empty? You must have some data!");const s=this.zeros(e*e);for(let i=0;i<e;i++)for(let n=i+1;n<e;n++){const r=t[i][n];s[i*e+n]=r,s[n*e+i]=r}this.P=this.d2p(s,this.perplexity,1e-4),this.N=e,this.initSolution()}initSolution(){this.Y=this.randn2d(this.N,this.dim),this.gains=this.randn2d(this.N,this.dim,1),this.ystep=this.randn2d(this.N,this.dim,0),this.iter=0}getSolution(){return this.Y}step(){this.iter+=1;const t=this.N,e=this.costGrad(this.Y),s=e.cost,i=e.grad,n=this.zeros(this.dim);for(let e=0;e<t;e++)for(let t=0;t<this.dim;t++){const s=i[e][t],r=this.ystep[e][t],o=this.gains[e][t];let a=this.sign(s)===this.sign(r)?.8*o:o+.2;a<.01&&(a=.01),this.gains[e][t]=a;const l=(this.iter<250?.5:.8)*r-this.epsilon*a*i[e][t];this.ystep[e][t]=l,this.Y[e][t]+=l,n[t]+=this.Y[e][t]}for(let e=0;e<t;e++)for(let s=0;s<this.dim;s++)this.Y[e][s]-=n[s]/t;return s}debugGrad(){const t=this.N,e=this.costGrad(this.Y),s=(e.cost,e.grad),i=1e-5;for(let e=0;e<t;e++)for(let t=0;t<this.dim;t++){const n=this.Y[e][t];this.Y[e][t]=n+i;const r=this.costGrad(this.Y);this.Y[e][t]=n-i;const o=this.costGrad(this.Y),a=s[e][t],l=(r.cost-o.cost)/(2*i);console.log(e+","+t+": gradcheck analytic: "+a+" vs. numerical: "+l),this.Y[e][t]=n}}costGrad(t){const e=this.N,s=this.dim,i=this.P,n=this.iter<100?4:1,r=this.zeros(e*e);let o=0;for(let i=0;i<e;i++)for(let n=i+1;n<e;n++){let a=0;for(let e=0;e<s;e++){const s=t[i][e]-t[n][e];a+=s*s}const l=1/(1+a);r[i*e+n]=l,r[n*e+i]=l,o+=2*l}const a=e*e,l=this.zeros(a);for(let t=0;t<a;t++)l[t]=Math.max(r[t]/o,1e-100);let h=0;const c=[];for(let o=0;o<e;o++){const a=new Array(s);for(let t=0;t<s;t++)a[t]=0;for(let c=0;c<e;c++){h+=-i[o*e+c]*Math.log(l[o*e+c]);const u=4*(n*i[o*e+c]-l[o*e+c])*r[o*e+c];for(let e=0;e<s;e++)a[e]+=u*(t[o][e]-t[c][e])}c.push(a)}return{cost:h,grad:c}}}},5362:(t,e,s)=>{"use strict";s.d(e,{Z:()=>a});var i=s(7537),n=s.n(i),r=s(3645),o=s.n(r)()(n());o.push([t.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=o},9564:(t,e,s)=>{"use strict";s.d(e,{Z:()=>a});var i=s(7537),n=s.n(i),r=s(3645),o=s.n(r)()(n());o.push([t.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=o},9414:(t,e,s)=>{"use strict";s.d(e,{Z:()=>a});var i=s(7537),n=s.n(i),r=s(3645),o=s.n(r)()(n());o.push([t.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n"],sourceRoot:""}]);const a=o},3645:t=>{"use strict";t.exports=function(t){var e=[];return e.toString=function(){return this.map((function(e){var s="",i=void 0!==e[5];return e[4]&&(s+="@supports (".concat(e[4],") {")),e[2]&&(s+="@media ".concat(e[2]," {")),i&&(s+="@layer".concat(e[5].length>0?" ".concat(e[5]):""," {")),s+=t(e),i&&(s+="}"),e[2]&&(s+="}"),e[4]&&(s+="}"),s})).join("")},e.i=function(t,s,i,n,r){"string"==typeof t&&(t=[[null,t,void 0]]);var o={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(o[l]=!0)}for(var h=0;h<t.length;h++){var c=[].concat(t[h]);i&&o[c[0]]||(void 0!==r&&(void 0===c[5]||(c[1]="@layer".concat(c[5].length>0?" ".concat(c[5]):""," {").concat(c[1],"}")),c[5]=r),s&&(c[2]?(c[1]="@media ".concat(c[2]," {").concat(c[1],"}"),c[2]=s):c[2]=s),n&&(c[4]?(c[1]="@supports (".concat(c[4],") {").concat(c[1],"}"),c[4]=n):c[4]="".concat(n)),e.push(c))}},e}},7537:t=>{"use strict";t.exports=function(t){var e=t[1],s=t[3];if(!s)return e;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(s)))),n="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),r="/*# ".concat(n," */");return[e].concat([r]).join("\n")}return[e].join("\n")}},9133:function(t,e,s){var i;!function(e,n){var r={};!function(t){"use strict";t.__esModule=!0,t.digestLength=32,t.blockSize=64;var e=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function s(t,s,i,n,r){for(var o,a,l,h,c,u,m,d,p,g,f,y,w;r>=64;){for(o=s[0],a=s[1],l=s[2],h=s[3],c=s[4],u=s[5],m=s[6],d=s[7],g=0;g<16;g++)f=n+4*g,t[g]=(255&i[f])<<24|(255&i[f+1])<<16|(255&i[f+2])<<8|255&i[f+3];for(g=16;g<64;g++)y=((p=t[g-2])>>>17|p<<15)^(p>>>19|p<<13)^p>>>10,w=((p=t[g-15])>>>7|p<<25)^(p>>>18|p<<14)^p>>>3,t[g]=(y+t[g-7]|0)+(w+t[g-16]|0);for(g=0;g<64;g++)y=(((c>>>6|c<<26)^(c>>>11|c<<21)^(c>>>25|c<<7))+(c&u^~c&m)|0)+(d+(e[g]+t[g]|0)|0)|0,w=((o>>>2|o<<30)^(o>>>13|o<<19)^(o>>>22|o<<10))+(o&a^o&l^a&l)|0,d=m,m=u,u=c,c=h+y|0,h=l,l=a,a=o,o=y+w|0;s[0]+=o,s[1]+=a,s[2]+=l,s[3]+=h,s[4]+=c,s[5]+=u,s[6]+=m,s[7]+=d,n+=64,r-=64}return n}var i=function(){function e(){this.digestLength=t.digestLength,this.blockSize=t.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return e.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},e.prototype.clean=function(){for(var t=0;t<this.buffer.length;t++)this.buffer[t]=0;for(t=0;t<this.temp.length;t++)this.temp[t]=0;this.reset()},e.prototype.update=function(t,e){if(void 0===e&&(e=t.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=e,this.bufferLength>0){for(;this.bufferLength<64&&e>0;)this.buffer[this.bufferLength++]=t[i++],e--;64===this.bufferLength&&(s(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(e>=64&&(i=s(this.temp,this.state,t,i,e),e%=64);e>0;)this.buffer[this.bufferLength++]=t[i++],e--;return this},e.prototype.finish=function(t){if(!this.finished){var e=this.bytesHashed,i=this.bufferLength,n=e/536870912|0,r=e<<3,o=e%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<o-8;a++)this.buffer[a]=0;this.buffer[o-8]=n>>>24&255,this.buffer[o-7]=n>>>16&255,this.buffer[o-6]=n>>>8&255,this.buffer[o-5]=n>>>0&255,this.buffer[o-4]=r>>>24&255,this.buffer[o-3]=r>>>16&255,this.buffer[o-2]=r>>>8&255,this.buffer[o-1]=r>>>0&255,s(this.temp,this.state,this.buffer,0,o),this.finished=!0}for(a=0;a<8;a++)t[4*a+0]=this.state[a]>>>24&255,t[4*a+1]=this.state[a]>>>16&255,t[4*a+2]=this.state[a]>>>8&255,t[4*a+3]=this.state[a]>>>0&255;return this},e.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},e.prototype._saveState=function(t){for(var e=0;e<this.state.length;e++)t[e]=this.state[e]},e.prototype._restoreState=function(t,e){for(var s=0;s<this.state.length;s++)this.state[s]=t[s];this.bytesHashed=e,this.finished=!1,this.bufferLength=0},e}();t.Hash=i;var n=function(){function t(t){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var e=new Uint8Array(this.blockSize);if(t.length>this.blockSize)(new i).update(t).finish(e).clean();else for(var s=0;s<t.length;s++)e[s]=t[s];for(s=0;s<e.length;s++)e[s]^=54;for(this.inner.update(e),s=0;s<e.length;s++)e[s]^=106;for(this.outer.update(e),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),s=0;s<e.length;s++)e[s]=0}return t.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},t.prototype.clean=function(){for(var t=0;t<this.istate.length;t++)this.ostate[t]=this.istate[t]=0;this.inner.clean(),this.outer.clean()},t.prototype.update=function(t){return this.inner.update(t),this},t.prototype.finish=function(t){return this.outer.finished?this.outer.finish(t):(this.inner.finish(t),this.outer.update(t,this.digestLength).finish(t)),this},t.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},t}();function r(t){var e=(new i).update(t),s=e.digest();return e.clean(),s}function o(t,e){var s=new n(t).update(e),i=s.digest();return s.clean(),i}function a(t,e,s,i){var n=i[0];if(0===n)throw new Error("hkdf: cannot expand more");e.reset(),n>1&&e.update(t),s&&e.update(s),e.update(i),e.finish(t),i[0]++}t.HMAC=n,t.hash=r,t.default=r,t.hmac=o;var l=new Uint8Array(t.digestLength);t.hkdf=function(t,e,s,i){void 0===e&&(e=l),void 0===i&&(i=32);for(var r=new Uint8Array([1]),h=o(e,t),c=new n(h),u=new Uint8Array(c.digestLength),m=u.length,d=new Uint8Array(i),p=0;p<i;p++)m===u.length&&(a(u,c,s,r),m=0),d[p]=u[m++];return c.clean(),u.fill(0),r.fill(0),d},t.pbkdf2=function(t,e,s,i){for(var r=new n(t),o=r.digestLength,a=new Uint8Array(4),l=new Uint8Array(o),h=new Uint8Array(o),c=new Uint8Array(i),u=0;u*o<i;u++){var m=u+1;a[0]=m>>>24&255,a[1]=m>>>16&255,a[2]=m>>>8&255,a[3]=m>>>0&255,r.reset(),r.update(e),r.update(a),r.finish(h);for(var d=0;d<o;d++)l[d]=h[d];for(d=2;d<=s;d++){r.reset(),r.update(h).finish(h);for(var p=0;p<o;p++)l[p]^=h[p]}for(d=0;d<o&&u*o+d<i;d++)c[u*o+d]=l[d]}for(u=0;u<o;u++)l[u]=h[u]=0;for(u=0;u<4;u++)a[u]=0;return r.clean(),c}}(r);var o=r.default;for(var a in r)o[a]=r[a];"object"==typeof t.exports?t.exports=o:void 0===(i=function(){return o}.call(r,s,r,t))||(t.exports=i)}()},1811:(t,e,s)=>{"use strict";s.d(e,{T:()=>n});const i=new Uint32Array(65536),n=(t,e)=>{if(t.length<e.length){const s=e;e=t,t=s}return 0===e.length?t.length:t.length<=32?((t,e)=>{const s=t.length,n=e.length,r=1<<s-1;let o=-1,a=0,l=s,h=s;for(;h--;)i[t.charCodeAt(h)]|=1<<h;for(h=0;h<n;h++){let t=i[e.charCodeAt(h)];const s=t|a;t|=(t&o)+o^o,a|=~(t|o),o&=t,a&r&&l++,o&r&&l--,a=a<<1|1,o=o<<1|~(s|a),a&=s}for(h=s;h--;)i[t.charCodeAt(h)]=0;return l})(t,e):((t,e)=>{const s=e.length,n=t.length,r=[],o=[],a=Math.ceil(s/32),l=Math.ceil(n/32);for(let t=0;t<a;t++)o[t]=-1,r[t]=0;let h=0;for(;h<l-1;h++){let a=0,l=-1;const c=32*h,u=Math.min(32,n)+c;for(let e=c;e<u;e++)i[t.charCodeAt(e)]|=1<<e;for(let t=0;t<s;t++){const s=i[e.charCodeAt(t)],n=o[t/32|0]>>>t&1,h=r[t/32|0]>>>t&1,c=s|a,u=((s|h)&l)+l^l|s|h;let m=a|~(u|l),d=l&u;m>>>31^n&&(o[t/32|0]^=1<<t),d>>>31^h&&(r[t/32|0]^=1<<t),m=m<<1|n,d=d<<1|h,l=d|~(c|m),a=m&c}for(let e=c;e<u;e++)i[t.charCodeAt(e)]=0}let c=0,u=-1;const m=32*h,d=Math.min(32,n-m)+m;for(let e=m;e<d;e++)i[t.charCodeAt(e)]|=1<<e;let p=n;for(let t=0;t<s;t++){const s=i[e.charCodeAt(t)],a=o[t/32|0]>>>t&1,l=r[t/32|0]>>>t&1,h=s|c,m=((s|l)&u)+u^u|s|l;let d=c|~(m|u),g=u&m;p+=d>>>n-1&1,p-=g>>>n-1&1,d>>>31^a&&(o[t/32|0]^=1<<t),g>>>31^l&&(r[t/32|0]^=1<<t),d=d<<1|a,g=g<<1|l,u=g|~(h|d),c=d&h}for(let e=m;e<d;e++)i[t.charCodeAt(e)]=0;return p})(t,e)}},3979:(t,e)=>{"use strict";e.H$=void 0,e.H$=function(t,e,s){var i=function(t,e,s){if(0===t.length||0===e.length)return 0;if(s&&!s.caseSensitive&&(t=t.toUpperCase(),e=e.toUpperCase()),t===e)return 1;for(var i=0,n=t.length,r=e.length,o=Math.floor(Math.max(n,r)/2)-1,a=new Array(n),l=new Array(r),h=0;h<n;h++)for(var c=Math.max(0,h-o);c<=Math.min(r,h+o+1);c++)if(!a[h]&&!l[c]&&t[h]===e[c]){++i,a[h]=l[c]=!0;break}if(0===i)return 0;var u=0,m=0;for(h=0;h<n;h++)if(a[h]){for(;!l[m];)m++;t.charAt(h)!==e.charAt(m++)&&u++}return(i/n+i/r+(i-(u/=2))/i)/3}(t,e,s),n=0;if(i>.7){for(var r=Math.min(t.length,e.length),o=0;t[o]===e[o]&&o<4&&o<r;)++n,o++;i+=.1*n*(1-i)}return i}},9251:(t,e,s)=>{"use strict";s.r(e),s.d(e,{default:()=>P});const i=Object.prototype.toString;function n(t){return i.call(t).endsWith("Array]")}function r(t,e,s){let i=0;const n=s(e);for(let e=0;e<t.x.length;e++)i+=Math.abs(t.y[e]-n(t.x[e]));return i}const o=Object.prototype.toString;function a(t){return o.call(t).endsWith("Array]")}const l=Object.prototype.toString;function h(t){return l.call(t).endsWith("Array]")}const c=Object.prototype.toString;const u=Object.prototype.toString;function m(t){var e,s=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!h(t))throw new TypeError("input must be an array");if(0===t.length)throw new TypeError("input must not be empty");if(void 0!==s.output){if(!h(s.output))throw new TypeError("output option must be an array if specified");e=s.output}else e=new Array(t.length);var i=function(t){var e,s=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(e=t,!u.call(e).endsWith("Array]"))throw new TypeError("input must be an array");if(0===t.length)throw new TypeError("input must not be empty");var i=s.fromIndex,n=void 0===i?0:i,r=s.toIndex,o=void 0===r?t.length:r;if(n<0||n>=t.length||!Number.isInteger(n))throw new Error("fromIndex must be a positive integer smaller than length");if(o<=n||o>t.length||!Number.isInteger(o))throw new Error("toIndex must be an integer greater than fromIndex and at most equal to length");for(var a=t[n],l=n+1;l<o;l++)t[l]<a&&(a=t[l]);return a}(t),n=function(t){var e,s=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(e=t,!c.call(e).endsWith("Array]"))throw new TypeError("input must be an array");if(0===t.length)throw new TypeError("input must not be empty");var i=s.fromIndex,n=void 0===i?0:i,r=s.toIndex,o=void 0===r?t.length:r;if(n<0||n>=t.length||!Number.isInteger(n))throw new Error("fromIndex must be a positive integer smaller than length");if(o<=n||o>t.length||!Number.isInteger(o))throw new Error("toIndex must be an integer greater than fromIndex and at most equal to length");for(var a=t[n],l=n+1;l<o;l++)t[l]>a&&(a=t[l]);return a}(t);if(i===n)throw new RangeError("minimum and maximum input values are equal. Cannot rescale a constant array");var r=s.min,o=void 0===r?s.autoMinMax?i:0:r,a=s.max,l=void 0===a?s.autoMinMax?n:1:a;if(o>=l)throw new RangeError("min option must be smaller than max option");for(var m=(l-o)/(n-i),d=0;d<t.length;d++)e[d]=(t[d]-i)*m+o;return e}const d=" ".repeat(2),p=" ".repeat(4);function g(t,e={}){const{maxRows:s=15,maxColumns:i=10,maxNumSize:n=8,padMinus:r="auto"}=e;return`${t.constructor.name} {\n${d}[\n${p}${function(t,e,s,i,n){const{rows:r,columns:o}=t,a=Math.min(r,e),l=Math.min(o,s),h=[];if("auto"===n){n=!1;t:for(let e=0;e<a;e++)for(let s=0;s<l;s++)if(t.get(e,s)<0){n=!0;break t}}for(let e=0;e<a;e++){let s=[];for(let r=0;r<l;r++)s.push(f(t.get(e,r),i,n));h.push(`${s.join(" ")}`)}return l!==o&&(h[h.length-1]+=` ... ${o-s} more columns`),a!==r&&h.push(`... ${r-e} more rows`),h.join(`\n${p}`)}(t,s,i,n,r)}\n${d}]\n${d}rows: ${t.rows}\n${d}columns: ${t.columns}\n}`}function f(t,e,s){return(t>=0&&s?` ${y(t,e-1)}`:y(t,e)).padEnd(e)}function y(t,e){let s=t.toString();if(s.length<=e)return s;let i=t.toFixed(e);if(i.length>e&&(i=t.toFixed(Math.max(0,e-(i.length-e)))),i.length<=e&&!i.startsWith("0.000")&&!i.startsWith("-0.000"))return i;let n=t.toExponential(e);return n.length>e&&(n=t.toExponential(Math.max(0,e-(n.length-e)))),n.slice(0)}function w(t,e,s){let i=s?t.rows:t.rows-1;if(e<0||e>i)throw new RangeError("Row index out of range")}function b(t,e,s){let i=s?t.columns:t.columns-1;if(e<0||e>i)throw new RangeError("Column index out of range")}function v(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.columns)throw new RangeError("vector size must be the same as the number of columns");return e}function C(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.rows)throw new RangeError("vector size must be the same as the number of rows");return e}function S(t,e,s,i,n){if(5!==arguments.length)throw new RangeError("expected 4 arguments");if(A("startRow",e),A("endRow",s),A("startColumn",i),A("endColumn",n),e>s||i>n||e<0||e>=t.rows||s<0||s>=t.rows||i<0||i>=t.columns||n<0||n>=t.columns)throw new RangeError("Submatrix indices are out of range")}function M(t,e=0){let s=[];for(let i=0;i<t;i++)s.push(e);return s}function A(t,e){if("number"!=typeof e)throw new TypeError(`${t} must be a number`)}function T(t){if(t.isEmpty())throw new Error("Empty matrix has no elements to index")}class E{static from1DArray(t,e,s){if(t*e!==s.length)throw new RangeError("data length does not match given dimensions");let i=new N(t,e);for(let n=0;n<t;n++)for(let t=0;t<e;t++)i.set(n,t,s[n*e+t]);return i}static rowVector(t){let e=new N(1,t.length);for(let s=0;s<t.length;s++)e.set(0,s,t[s]);return e}static columnVector(t){let e=new N(t.length,1);for(let s=0;s<t.length;s++)e.set(s,0,t[s]);return e}static zeros(t,e){return new N(t,e)}static ones(t,e){return new N(t,e).fill(1)}static rand(t,e,s={}){if("object"!=typeof s)throw new TypeError("options must be an object");const{random:i=Math.random}=s;let n=new N(t,e);for(let s=0;s<t;s++)for(let t=0;t<e;t++)n.set(s,t,i());return n}static randInt(t,e,s={}){if("object"!=typeof s)throw new TypeError("options must be an object");const{min:i=0,max:n=1e3,random:r=Math.random}=s;if(!Number.isInteger(i))throw new TypeError("min must be an integer");if(!Number.isInteger(n))throw new TypeError("max must be an integer");if(i>=n)throw new RangeError("min must be smaller than max");let o=n-i,a=new N(t,e);for(let s=0;s<t;s++)for(let t=0;t<e;t++){let e=i+Math.round(r()*o);a.set(s,t,e)}return a}static eye(t,e,s){void 0===e&&(e=t),void 0===s&&(s=1);let i=Math.min(t,e),n=this.zeros(t,e);for(let t=0;t<i;t++)n.set(t,t,s);return n}static diag(t,e,s){let i=t.length;void 0===e&&(e=i),void 0===s&&(s=e);let n=Math.min(i,e,s),r=this.zeros(e,s);for(let e=0;e<n;e++)r.set(e,e,t[e]);return r}static min(t,e){t=this.checkMatrix(t),e=this.checkMatrix(e);let s=t.rows,i=t.columns,n=new N(s,i);for(let r=0;r<s;r++)for(let s=0;s<i;s++)n.set(r,s,Math.min(t.get(r,s),e.get(r,s)));return n}static max(t,e){t=this.checkMatrix(t),e=this.checkMatrix(e);let s=t.rows,i=t.columns,n=new this(s,i);for(let r=0;r<s;r++)for(let s=0;s<i;s++)n.set(r,s,Math.max(t.get(r,s),e.get(r,s)));return n}static checkMatrix(t){return E.isMatrix(t)?t:new N(t)}static isMatrix(t){return null!=t&&"Matrix"===t.klass}get size(){return this.rows*this.columns}apply(t){if("function"!=typeof t)throw new TypeError("callback must be a function");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.call(this,e,s);return this}to1DArray(){let t=[];for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.push(this.get(e,s));return t}to2DArray(){let t=[];for(let e=0;e<this.rows;e++){t.push([]);for(let s=0;s<this.columns;s++)t[e].push(this.get(e,s))}return t}toJSON(){return this.to2DArray()}isRowVector(){return 1===this.rows}isColumnVector(){return 1===this.columns}isVector(){return 1===this.rows||1===this.columns}isSquare(){return this.rows===this.columns}isEmpty(){return 0===this.rows||0===this.columns}isSymmetric(){if(this.isSquare()){for(let t=0;t<this.rows;t++)for(let e=0;e<=t;e++)if(this.get(t,e)!==this.get(e,t))return!1;return!0}return!1}isEchelonForm(){let t=0,e=0,s=-1,i=!0,n=!1;for(;t<this.rows&&i;){for(e=0,n=!1;e<this.columns&&!1===n;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(n=!0,s=e):(i=!1,n=!0);t++}return i}isReducedEchelonForm(){let t=0,e=0,s=-1,i=!0,n=!1;for(;t<this.rows&&i;){for(e=0,n=!1;e<this.columns&&!1===n;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(n=!0,s=e):(i=!1,n=!0);for(let s=e+1;s<this.rows;s++)0!==this.get(t,s)&&(i=!1);t++}return i}echelonForm(){let t=this.clone(),e=0,s=0;for(;e<t.rows&&s<t.columns;){let i=e;for(let n=e;n<t.rows;n++)t.get(n,s)>t.get(i,s)&&(i=n);if(0===t.get(i,s))s++;else{t.swapRows(e,i);let n=t.get(e,s);for(let i=s;i<t.columns;i++)t.set(e,i,t.get(e,i)/n);for(let i=e+1;i<t.rows;i++){let n=t.get(i,s)/t.get(e,s);t.set(i,s,0);for(let r=s+1;r<t.columns;r++)t.set(i,r,t.get(i,r)-t.get(e,r)*n)}e++,s++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,s=t.rows,i=s-1;for(;i>=0;)if(0===t.maxRow(i))i--;else{let n=0,r=!1;for(;n<s&&!1===r;)1===t.get(i,n)?r=!0:n++;for(let s=0;s<i;s++){let r=t.get(s,n);for(let o=n;o<e;o++){let e=t.get(s,o)-r*t.get(i,o);t.set(s,o,e)}}i--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:s=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(s)||s<=0)throw new TypeError("columns must be a positive integer");let i=new N(this.rows*e,this.columns*s);for(let t=0;t<e;t++)for(let e=0;e<s;e++)i.setSubMatrix(this,this.rows*t,this.columns*e);return i}fill(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,t);return this}neg(){return this.mulS(-1)}getRow(t){w(this,t);let e=[];for(let s=0;s<this.columns;s++)e.push(this.get(t,s));return e}getRowVector(t){return N.rowVector(this.getRow(t))}setRow(t,e){w(this,t),e=v(this,e);for(let s=0;s<this.columns;s++)this.set(t,s,e[s]);return this}swapRows(t,e){w(this,t),w(this,e);for(let s=0;s<this.columns;s++){let i=this.get(t,s);this.set(t,s,this.get(e,s)),this.set(e,s,i)}return this}getColumn(t){b(this,t);let e=[];for(let s=0;s<this.rows;s++)e.push(this.get(s,t));return e}getColumnVector(t){return N.columnVector(this.getColumn(t))}setColumn(t,e){b(this,t),e=C(this,e);for(let s=0;s<this.rows;s++)this.set(s,t,e[s]);return this}swapColumns(t,e){b(this,t),b(this,e);for(let s=0;s<this.rows;s++){let i=this.get(s,t);this.set(s,t,this.get(s,e)),this.set(s,e,i)}return this}addRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[s]);return this}subRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[s]);return this}mulRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[s]);return this}divRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[s]);return this}addColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[e]);return this}subColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[e]);return this}mulColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[e]);return this}divColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[e]);return this}mulRow(t,e){w(this,t);for(let s=0;s<this.columns;s++)this.set(t,s,this.get(t,s)*e);return this}mulColumn(t,e){b(this,t);for(let s=0;s<this.rows;s++)this.set(s,t,this.get(s,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){T(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)>t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){T(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)<t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}maxRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)>e&&(e=this.get(t,s));return e}maxRowIndex(t){w(this,t),T(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),s[1]=i);return s}minRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){w(this,t),T(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),s[1]=i);return s}maxColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),s[0]=i);return s}minColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),s[0]=i);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let i=0;i<e.length;i++)s+=e[i]*t[i];return s}mmul(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,i=t.columns,n=new N(e,i),r=new Float64Array(s);for(let o=0;o<i;o++){for(let e=0;e<s;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let i=0;i<s;i++)e+=this.get(t,i)*r[i];n.set(t,o,e)}}return n}strassen2x2(t){t=N.checkMatrix(t);let e=new N(2,2);const s=this.get(0,0),i=t.get(0,0),n=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(i+h),u=(o+l)*i,m=s*(r-h),d=l*(a-i),p=(s+n)*h,g=c+d-p+(n-l)*(a+h),f=m+p,y=u+d,w=c-u+m+(o-s)*(i+r);return e.set(0,0,g),e.set(0,1,f),e.set(1,0,y),e.set(1,1,w),e}strassen3x3(t){t=N.checkMatrix(t);let e=new N(3,3);const s=this.get(0,0),i=this.get(0,1),n=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),p=t.get(1,0),g=t.get(1,1),f=t.get(1,2),y=t.get(2,0),w=t.get(2,1),b=t.get(2,2),v=(s-r)*(-m+g),C=(-s+r+o)*(u-m+g),S=(r+o)*(-u+m),M=s*u,A=(-s+l+h)*(u-d+f),T=(-s+l)*(d-f),E=(l+h)*(-u+d),x=(-n+h+c)*(g+y-w),L=(n-c)*(g-w),I=n*y,_=(h+c)*(-y+w),R=(-n+o+a)*(f+y-b),O=(n-a)*(f-b),k=(o+a)*(-y+b),P=M+I+i*p,G=(s+i+n-r-o-h-c)*g+C+S+M+x+I+_,F=M+A+E+(s+i+n-o-a-l-h)*f+I+R+k,W=v+o*(-u+m+p-g-f-y+b)+C+M+I+R+O,H=v+C+S+M+a*w,V=I+R+O+k+r*d,D=M+A+T+h*(-u+d+p-g-f-y+w)+x+L+I,B=x+L+I+_+l*m,U=M+A+T+E+c*b;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,W),e.set(1,1,H),e.set(1,2,V),e.set(2,0,D),e.set(2,1,B),e.set(2,2,U),e}mmulStrassen(t){t=N.checkMatrix(t);let e=this.clone(),s=e.rows,i=e.columns,n=t.rows,r=t.columns;function o(t,e,s){let i=t.rows,n=t.columns;if(i===e&&n===s)return t;{let i=E.zeros(e,s);return i=i.setSubMatrix(t,0,0),i}}i!==n&&console.warn(`Multiplying ${s} x ${i} and ${n} x ${r} matrix: dimensions do not match.`);let a=Math.max(s,n),l=Math.max(i,r);return e=o(e,a,l),function t(e,s,i,n){if(i<=512||n<=512)return e.mmul(s);i%2==1&&n%2==1?(e=o(e,i+1,n+1),s=o(s,i+1,n+1)):i%2==1?(e=o(e,i+1,n),s=o(s,i+1,n)):n%2==1&&(e=o(e,i,n+1),s=o(s,i,n+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=s.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=s.subMatrix(0,r-1,a,s.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=s.subMatrix(r,s.rows-1,0,a-1),p=e.subMatrix(r,e.rows-1,a,e.columns-1),g=s.subMatrix(r,s.rows-1,a,s.columns-1),f=t(E.add(l,p),E.add(h,g),r,a),y=t(E.add(m,p),h,r,a),w=t(l,E.sub(u,g),r,a),b=t(p,E.sub(d,h),r,a),v=t(E.add(l,c),g,r,a),C=t(E.sub(m,l),E.add(h,u),r,a),S=t(E.sub(c,p),E.add(d,g),r,a),M=E.add(f,b);M.sub(v),M.add(S);let A=E.add(w,v),T=E.add(y,b),x=E.sub(f,y);x.add(w),x.add(C);let N=E.zeros(2*M.rows,2*M.columns);return N=N.setSubMatrix(M,0,0),N=N.setSubMatrix(A,M.rows,0),N=N.setSubMatrix(T,0,M.columns),N=N.setSubMatrix(x,M.rows,M.columns),N.subMatrix(0,i-1,0,n-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let i=new N(this.rows,this.columns);for(let t=0;t<this.rows;t++){const n=this.getRow(t);n.length>0&&m(n,{min:e,max:s,output:n}),i.setRow(t,n)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let i=new N(this.rows,this.columns);for(let t=0;t<this.columns;t++){const n=this.getColumn(t);n.length&&m(n,{min:e,max:s,output:n}),i.setColumn(t,n)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let s=0;s<t;s++){let t=this.get(e,s),i=this.get(e,this.columns-1-s);this.set(e,s,i),this.set(e,this.columns-1-s,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let s=0;s<t;s++){let t=this.get(s,e),i=this.get(this.rows-1-s,e);this.set(s,e,i),this.set(this.rows-1-s,e,t)}return this}kroneckerProduct(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,i=t.rows,n=t.columns,r=new N(e*i,s*n);for(let o=0;o<e;o++)for(let e=0;e<s;e++)for(let s=0;s<i;s++)for(let a=0;a<n;a++)r.set(i*o+s,n*e+a,this.get(o,e)*t.get(s,a));return r}kroneckerSum(t){if(t=N.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,s=t.rows,i=this.kroneckerProduct(N.eye(s,s)),n=N.eye(e,e).kroneckerProduct(t);return i.add(n)}transpose(){let t=new N(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(s,e,this.get(e,s));return t}sortRows(t=x){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=x){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,s,i){S(this,t,e,s,i);let n=new N(e-t+1,i-s+1);for(let r=t;r<=e;r++)for(let e=s;e<=i;e++)n.set(r-t,e-s,this.get(r,e));return n}subMatrixRow(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.columns-1),e>s||e<0||e>=this.columns||s<0||s>=this.columns)throw new RangeError("Argument out of range");let i=new N(t.length,s-e+1);for(let n=0;n<t.length;n++)for(let r=e;r<=s;r++){if(t[n]<0||t[n]>=this.rows)throw new RangeError(`Row index out of range: ${t[n]}`);i.set(n,r-e,this.get(t[n],r))}return i}subMatrixColumn(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.rows-1),e>s||e<0||e>=this.rows||s<0||s>=this.rows)throw new RangeError("Argument out of range");let i=new N(s-e+1,t.length);for(let n=0;n<t.length;n++)for(let r=e;r<=s;r++){if(t[n]<0||t[n]>=this.columns)throw new RangeError(`Column index out of range: ${t[n]}`);i.set(r-e,n,this.get(r,t[n]))}return i}setSubMatrix(t,e,s){if((t=N.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,s,s+t.columns-1);for(let i=0;i<t.rows;i++)for(let n=0;n<t.columns;n++)this.set(e+i,s+n,t.get(i,n));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let s=new N(t.length,e.length);for(let i=0;i<t.length;i++){let n=t[i];for(let t=0;t<e.length;t++){let r=e[t];s.set(i,t,this.get(n,r))}}return s}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let s=0;s<t;s++)e+=this.get(s,s);return e}clone(){let t=new N(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(e,s,this.get(e,s));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[s]+=t.get(s,i);return e}(this);case"column":return function(t){let e=M(t.columns);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[i]+=t.get(s,i);return e}(this);case void 0:return function(t){let e=0;for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)e+=t.get(s,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[s]*=t.get(s,i);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[i]*=t.get(s,i);return e}(this);case void 0:return function(t){let e=1;for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)e*=t.get(s,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:s=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof s)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,s){const i=t.rows,n=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<n;e++)l=t.get(o,e)-s[o],i+=l,a+=l*l;e?r.push((a-i*i/n)/(n-1)):r.push((a-i*i/n)/n)}return r}(this,s,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,s){const i=t.rows,n=t.columns,r=[];for(let o=0;o<n;o++){let n=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,o)-s[o],n+=l,a+=l*l;e?r.push((a-n*n/i)/(i-1)):r.push((a-n*n/i)/i)}return r}(this,s,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,s){const i=t.rows,n=t.columns,r=i*n;let o=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<n;i++)l=t.get(e,i)-s,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,s,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const s=this.variance(t,e);if(void 0===t)return Math.sqrt(s);for(let t=0;t<s.length;t++)s[t]=Math.sqrt(s[t]);return s}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:s=this.mean(t)}=e;switch(t){case"row":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e[s])}(this,s),this;case"column":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e[i])}(this,s),this;case void 0:if("number"!=typeof s)throw new TypeError("center must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let s=e.scale;switch(t){case"row":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.rows;s++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(s,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e[s])}(this,s),this;case"column":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.columns;s++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,s),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e[i])}(this,s),this;case void 0:if(void 0===s)s=function(t){const e=t.size-1;let s=0;for(let i=0;i<t.columns;i++)for(let n=0;n<t.rows;n++)s+=Math.pow(t.get(n,i),2)/e;return Math.sqrt(s)}(this);else if("number"!=typeof s)throw new TypeError("scale must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return g(this,t)}}function x(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return g(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class N extends E{constructor(t,e){if(super(),N.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let s=0;s<t;s++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const s=t;if("number"!=typeof(e=(t=s.length)?s[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(s[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!s[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(s[i]))}}}this.rows=t,this.columns=e}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}removeRow(t){return w(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),w(this,t,!0),e=Float64Array.from(v(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){b(this,t);for(let e=0;e<this.rows;e++){const s=new Float64Array(this.columns-1);for(let i=0;i<t;i++)s[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)s[i-1]=this.data[e][i];this.data[e]=s}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),b(this,t,!0),e=C(this,e);for(let s=0;s<this.rows;s++){const i=new Float64Array(this.columns+1);let n=0;for(;n<t;n++)i[n]=this.data[s][n];for(i[n++]=e[s];n<this.columns+1;n++)i[n]=this.data[s][n-1];this.data[s]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t.get(e,s));return this},t.add=function(t,s){return new e(t).add(s)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t.get(e,s));return this},t.sub=function(t,s){return new e(t).sub(s)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t.get(e,s));return this},t.mul=function(t,s){return new e(t).mul(s)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t.get(e,s));return this},t.div=function(t,s){return new e(t).div(s)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t.get(e,s));return this},t.mod=function(t,s){return new e(t).mod(s)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t.get(e,s));return this},t.and=function(t,s){return new e(t).and(s)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t.get(e,s));return this},t.or=function(t,s){return new e(t).or(s)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t.get(e,s));return this},t.xor=function(t,s){return new e(t).xor(s)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t.get(e,s));return this},t.leftShift=function(t,s){return new e(t).leftShift(s)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t.get(e,s));return this},t.signPropagatingRightShift=function(t,s){return new e(t).signPropagatingRightShift(s)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t.get(e,s));return this},t.rightShift=function(t,s){return new e(t).rightShift(s)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,s){return new e(t).pow(s)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t.get(e,s)));return this}}(E,N);class L extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}}class I{constructor(t){let e,s,i,n,r,o,a,l,h,c=(t=L.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),p=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),s=0;s<m;s++){for(e=0;e<u;e++)l[e]=c.get(e,s);for(e=0;e<u;e++){for(h=Math.min(e,s),r=0,i=0;i<h;i++)r+=c.get(e,i)*l[i];l[e]-=r,c.set(e,s,l[e])}for(n=s,e=s+1;e<u;e++)Math.abs(l[e])>Math.abs(l[n])&&(n=e);if(n!==s){for(i=0;i<m;i++)o=c.get(n,i),c.set(n,i,c.get(s,i)),c.set(s,i,o);a=d[n],d[n]=d[s],d[s]=a,p=-p}if(s<u&&0!==c.get(s,s))for(e=s+1;e<u;e++)c.set(e,s,c.get(e,s)/c.get(s,s))}this.LU=c,this.pivotVector=d,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=N.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,i,n,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(n=0;n<a;n++)for(s=n+1;s<a;s++)for(i=0;i<r;i++)o.set(s,i,o.get(s,i)-o.get(n,i)*e.get(s,n));for(n=a-1;n>=0;n--){for(i=0;i<r;i++)o.set(n,i,o.get(n,i)/e.get(n,n));for(s=0;s<n;s++)for(i=0;i<r;i++)o.set(s,i,o.get(s,i)-o.get(n,i)*e.get(s,n))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let i=0;i<s;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,i=new N(e,s);for(let n=0;n<e;n++)for(let e=0;e<s;e++)n>e?i.set(n,e,t.get(n,e)):n===e?i.set(n,e,1):i.set(n,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,i=new N(e,s);for(let n=0;n<e;n++)for(let e=0;e<s;e++)n<=e?i.set(n,e,t.get(n,e)):i.set(n,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function _(t,e){let s=0;return Math.abs(t)>Math.abs(e)?(s=e/t,Math.abs(t)*Math.sqrt(1+s*s)):0!==e?(s=t/e,Math.abs(e)*Math.sqrt(1+s*s)):0}class R{constructor(t){let e,s,i,n,r=(t=L.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<o;e++)t=_(t,r.get(e,i));if(0!==t){for(r.get(i,i)<0&&(t=-t),e=i;e<o;e++)r.set(e,i,r.get(e,i)/t);for(r.set(i,i,r.get(i,i)+1),s=i+1;s<a;s++){for(n=0,e=i;e<o;e++)n+=r.get(e,i)*r.get(e,s);for(n=-n/r.get(i,i),e=i;e<o;e++)r.set(e,s,r.get(e,s)+n*r.get(e,i))}}l[i]=-t}this.QR=r,this.Rdiag=l}solve(t){t=N.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,n,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(n=0;n<a;n++){for(o=0,i=r;i<s;i++)o+=e.get(i,r)*l.get(i,n);for(o=-o/e.get(r,r),i=r;i<s;i++)l.set(i,n,l.get(i,n)+o*e.get(i,r))}for(r=h-1;r>=0;r--){for(n=0;n<a;n++)l.set(r,n,l.get(r,n)/this.Rdiag[r]);for(i=0;i<r;i++)for(n=0;n<a;n++)l.set(i,n,l.get(i,n)-l.get(r,n)*e.get(i,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,i=s.columns,n=new N(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?n.set(t,e,s.get(t,e)):t===e?n.set(t,e,this.Rdiag[t]):n.set(t,e,0);return n}get orthogonalMatrix(){let t,e,s,i,n=this.QR,r=n.rows,o=n.columns,a=new N(r,o);for(s=o-1;s>=0;s--){for(t=0;t<r;t++)a.set(t,s,0);for(a.set(s,s,1),e=s;e<o;e++)if(0!==n.get(s,s)){for(i=0,t=s;t<r;t++)i+=n.get(t,s)*a.get(t,e);for(i=-i/n.get(s,s),t=s;t<r;t++)a.set(t,e,a.get(t,e)+i*n.get(t,s))}}return a}}class O{constructor(t,e={}){if((t=L.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,i=t.columns;const{computeLeftSingularVectors:n=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(n),h=Boolean(r),c=!1;if(s<i)if(o){a=t.transpose(),s=a.rows,i=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(s,i),m=Math.min(s+1,i),d=new Float64Array(m),p=new N(s,u),g=new N(i,i),f=new Float64Array(i),y=new Float64Array(s),w=new Float64Array(m);for(let t=0;t<m;t++)w[t]=t;let b=Math.min(s-1,i),v=Math.max(0,Math.min(i-2,s)),C=Math.max(b,v);for(let t=0;t<C;t++){if(t<b){d[t]=0;for(let e=t;e<s;e++)d[t]=_(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<s;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<i;e++){if(t<b&&0!==d[t]){let i=0;for(let n=t;n<s;n++)i+=a.get(n,t)*a.get(n,e);i=-i/a.get(t,t);for(let n=t;n<s;n++)a.set(n,e,a.get(n,e)+i*a.get(n,t))}f[e]=a.get(t,e)}if(l&&t<b)for(let e=t;e<s;e++)p.set(e,t,a.get(e,t));if(t<v){f[t]=0;for(let e=t+1;e<i;e++)f[t]=_(f[t],f[e]);if(0!==f[t]){f[t+1]<0&&(f[t]=0-f[t]);for(let e=t+1;e<i;e++)f[e]/=f[t];f[t+1]+=1}if(f[t]=-f[t],t+1<s&&0!==f[t]){for(let e=t+1;e<s;e++)y[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<i;s++)y[e]+=f[s]*a.get(e,s);for(let e=t+1;e<i;e++){let i=-f[e]/f[t+1];for(let n=t+1;n<s;n++)a.set(n,e,a.get(n,e)+i*y[n])}}if(h)for(let e=t+1;e<i;e++)g.set(e,t,f[e])}}let S=Math.min(i,s+1);if(b<i&&(d[b]=a.get(b,b)),s<S&&(d[S-1]=0),v+1<S&&(f[v]=a.get(v,S-1)),f[S-1]=0,l){for(let t=b;t<u;t++){for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}for(let t=b-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let i=0;for(let n=t;n<s;n++)i+=p.get(n,t)*p.get(n,e);i=-i/p.get(t,t);for(let n=t;n<s;n++)p.set(n,e,p.get(n,e)+i*p.get(n,t))}for(let e=t;e<s;e++)p.set(e,t,-p.get(e,t));p.set(t,t,1+p.get(t,t));for(let e=0;e<t-1;e++)p.set(e,t,0)}else{for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<v&&0!==f[t])for(let e=t+1;e<i;e++){let s=0;for(let n=t+1;n<i;n++)s+=g.get(n,t)*g.get(n,e);s=-s/g.get(t+1,t);for(let n=t+1;n<i;n++)g.set(n,e,g.get(n,e)+s*g.get(n,t))}for(let e=0;e<i;e++)g.set(e,t,0);g.set(t,t,1)}let M=S-1,A=0,T=Number.EPSILON;for(;S>0;){let t,e;for(t=S-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+T*Math.abs(d[t]+Math.abs(d[t+1]));if(Math.abs(f[t])<=e||Number.isNaN(f[t])){f[t]=0;break}}if(t===S-2)e=4;else{let s;for(s=S-1;s>=t&&s!==t;s--){let e=(s!==S?Math.abs(f[s]):0)+(s!==t+1?Math.abs(f[s-1]):0);if(Math.abs(d[s])<=T*e){d[s]=0;break}}s===t?e=3:s===S-1?e=1:(e=2,t=s)}switch(t++,e){case 1:{let e=f[S-2];f[S-2]=0;for(let s=S-2;s>=t;s--){let n=_(d[s],e),r=d[s]/n,o=e/n;if(d[s]=n,s!==t&&(e=-o*f[s-1],f[s-1]=r*f[s-1]),h)for(let t=0;t<i;t++)n=r*g.get(t,s)+o*g.get(t,S-1),g.set(t,S-1,-o*g.get(t,s)+r*g.get(t,S-1)),g.set(t,s,n)}break}case 2:{let e=f[t-1];f[t-1]=0;for(let i=t;i<S;i++){let n=_(d[i],e),r=d[i]/n,o=e/n;if(d[i]=n,e=-o*f[i],f[i]=r*f[i],l)for(let e=0;e<s;e++)n=r*p.get(e,i)+o*p.get(e,t-1),p.set(e,t-1,-o*p.get(e,i)+r*p.get(e,t-1)),p.set(e,i,n)}break}case 3:{const e=Math.max(Math.abs(d[S-1]),Math.abs(d[S-2]),Math.abs(f[S-2]),Math.abs(d[t]),Math.abs(f[t])),n=d[S-1]/e,r=d[S-2]/e,o=f[S-2]/e,a=d[t]/e,c=f[t]/e,u=((r+n)*(r-n)+o*o)/2,m=n*o*(n*o);let y=0;0===u&&0===m||(y=u<0?0-Math.sqrt(u*u+m):Math.sqrt(u*u+m),y=m/(u+y));let w=(a+n)*(a-n)+y,b=a*c;for(let e=t;e<S-1;e++){let n=_(w,b);0===n&&(n=Number.MIN_VALUE);let r=w/n,o=b/n;if(e!==t&&(f[e-1]=n),w=r*d[e]+o*f[e],f[e]=r*f[e]-o*d[e],b=o*d[e+1],d[e+1]=r*d[e+1],h)for(let t=0;t<i;t++)n=r*g.get(t,e)+o*g.get(t,e+1),g.set(t,e+1,-o*g.get(t,e)+r*g.get(t,e+1)),g.set(t,e,n);if(n=_(w,b),0===n&&(n=Number.MIN_VALUE),r=w/n,o=b/n,d[e]=n,w=r*f[e]+o*d[e+1],d[e+1]=-o*f[e]+r*d[e+1],b=o*f[e+1],f[e+1]=r*f[e+1],l&&e<s-1)for(let t=0;t<s;t++)n=r*p.get(t,e)+o*p.get(t,e+1),p.set(t,e+1,-o*p.get(t,e)+r*p.get(t,e+1)),p.set(t,e,n)}f[S-2]=w,A+=1;break}case 4:if(d[t]<=0&&(d[t]=d[t]<0?-d[t]:0,h))for(let e=0;e<=M;e++)g.set(e,t,-g.get(e,t));for(;t<M&&!(d[t]>=d[t+1]);){let e=d[t];if(d[t]=d[t+1],d[t+1]=e,h&&t<i-1)for(let s=0;s<i;s++)e=g.get(s,t+1),g.set(s,t+1,g.get(s,t)),g.set(s,t,e);if(l&&t<s-1)for(let i=0;i<s;i++)e=p.get(i,t+1),p.set(i,t+1,p.get(i,t)),p.set(i,t,e);t++}A=0,S--}}if(c){let t=g;g=p,p=t}this.m=s,this.n=i,this.s=d,this.U=p,this.V=g}solve(t){let e=t,s=this.threshold,i=this.s.length,n=N.zeros(i,i);for(let t=0;t<i;t++)Math.abs(this.s[t])<=s?n.set(t,t,0):n.set(t,t,1/this.s[t]);let r=this.U,o=this.rightSingularVectors,a=o.mmul(n),l=o.rows,h=r.rows,c=N.zeros(l,h);for(let t=0;t<l;t++)for(let e=0;e<h;e++){let s=0;for(let n=0;n<i;n++)s+=a.get(t,n)*r.get(e,n);c.set(t,e,s)}return c.mmul(e)}solveForDiagonal(t){return this.solve(N.diag(t))}inverse(){let t=this.V,e=this.threshold,s=t.rows,i=t.columns,n=new N(s,this.s.length);for(let r=0;r<s;r++)for(let s=0;s<i;s++)Math.abs(this.s[s])>e&&n.set(r,s,t.get(r,s)/this.s[s]);let r=this.U,o=r.rows,a=r.columns,l=new N(s,o);for(let t=0;t<s;t++)for(let e=0;e<o;e++){let s=0;for(let i=0;i<a;i++)s+=n.get(t,i)*r.get(e,i);l.set(t,e,s)}return l}get condition(){return this.s[0]/this.s[Math.min(this.m,this.n)-1]}get norm2(){return this.s[0]}get rank(){let t=Math.max(this.m,this.n)*this.s[0]*Number.EPSILON,e=0,s=this.s;for(let i=0,n=s.length;i<n;i++)s[i]>t&&e++;return e}get diagonal(){return Array.from(this.s)}get threshold(){return Number.EPSILON/2*Math.max(this.m,this.n)*this.s[0]}get leftSingularVectors(){return this.U}get rightSingularVectors(){return this.V}get diagonalMatrix(){return N.diag(this.s)}}function k(t,e,s,i,n){let r=s*i*i,o=N.eye(e.length,e.length,r);const a=n(e);let l=new Float64Array(t.x.length);for(let e=0;e<t.x.length;e++)l[e]=a(t.x[e]);let h=function(t,e,s,i,n){const r=s.length,o=t.x.length;let a=new Array(r);for(let l=0;l<r;l++){a[l]=new Array(o);let r=s.slice();r[l]+=i;let h=n(r);for(let s=0;s<o;s++)a[l][s]=e[s]-h(t.x[s])}return new N(a)}(t,l,e,i,n),c=function(t,e){const s=t.x.length;let i=new Array(s);for(let n=0;n<s;n++)i[n]=[t.y[n]-e[n]];return new N(i)}(t,l),u=function(t,e=!1){return t=L.checkMatrix(t),e?new O(t).inverse():function(t,e,s=!1){return t=L.checkMatrix(t),e=L.checkMatrix(e),s?new O(t).solve(e):t.isSquare()?new I(t).solve(e):new R(t).solve(e)}(t,N.eye(t.rows))}(o.add(h.mmul(h.transpose())));return(e=(e=new N([e])).sub(u.mmul(h).mmul(c).mul(i).transpose())).to1DArray()}function P(t,e,s={}){let{maxIterations:i=100,gradientDifference:o=.1,damping:a=0,errorTolerance:l=.01,minValues:h,maxValues:c,initialValues:u}=s;if(a<=0)throw new Error("The damping option must be a positive number");if(!t.x||!t.y)throw new Error("The data parameter must have x and y elements");if(!n(t.x)||t.x.length<2||!n(t.y)||t.y.length<2)throw new Error("The data parameter elements must be an array with more than 2 points");if(t.x.length!==t.y.length)throw new Error("The data parameter elements must have the same size");let m=u||new Array(e.length).fill(1),d=m.length;if(c=c||new Array(d).fill(Number.MAX_SAFE_INTEGER),h=h||new Array(d).fill(Number.MIN_SAFE_INTEGER),c.length!==h.length)throw new Error("minValues and maxValues must be the same size");if(!n(m))throw new Error("initialValues must be an array");let p,g=r(t,m,e),f=g<=l;for(p=0;p<i&&!f;p++){m=k(t,m,a,o,e);for(let t=0;t<d;t++)m[t]=Math.min(Math.max(h[t],m[t]),c[t]);if(g=r(t,m,e),isNaN(g))break;f=g<=l}return{parameterValues:m,parameterError:g,iterations:p}}},3379:t=>{"use strict";var e=[];function s(t){for(var s=-1,i=0;i<e.length;i++)if(e[i].identifier===t){s=i;break}return s}function i(t,i){for(var r={},o=[],a=0;a<t.length;a++){var l=t[a],h=i.base?l[0]+i.base:l[0],c=r[h]||0,u="".concat(h," ").concat(c);r[h]=c+1;var m=s(u),d={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==m)e[m].references++,e[m].updater(d);else{var p=n(d,i);i.byIndex=a,e.splice(a,0,{identifier:u,updater:p,references:1})}o.push(u)}return o}function n(t,e){var s=e.domAPI(e);return s.update(t),function(e){if(e){if(e.css===t.css&&e.media===t.media&&e.sourceMap===t.sourceMap&&e.supports===t.supports&&e.layer===t.layer)return;s.update(t=e)}else s.remove()}}t.exports=function(t,n){var r=i(t=t||[],n=n||{});return function(t){t=t||[];for(var o=0;o<r.length;o++){var a=s(r[o]);e[a].references--}for(var l=i(t,n),h=0;h<r.length;h++){var c=s(r[h]);0===e[c].references&&(e[c].updater(),e.splice(c,1))}r=l}}},569:t=>{"use strict";var e={};t.exports=function(t,s){var i=function(t){if(void 0===e[t]){var s=document.querySelector(t);if(window.HTMLIFrameElement&&s instanceof window.HTMLIFrameElement)try{s=s.contentDocument.head}catch(t){s=null}e[t]=s}return e[t]}(t);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(s)}},9216:t=>{"use strict";t.exports=function(t){var e=document.createElement("style");return t.setAttributes(e,t.attributes),t.insert(e,t.options),e}},3565:(t,e,s)=>{"use strict";t.exports=function(t){var e=s.nc;e&&t.setAttribute("nonce",e)}},7795:t=>{"use strict";t.exports=function(t){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var e=t.insertStyleElement(t);return{update:function(s){!function(t,e,s){var i="";s.supports&&(i+="@supports (".concat(s.supports,") {")),s.media&&(i+="@media ".concat(s.media," {"));var n=void 0!==s.layer;n&&(i+="@layer".concat(s.layer.length>0?" ".concat(s.layer):""," {")),i+=s.css,n&&(i+="}"),s.media&&(i+="}"),s.supports&&(i+="}");var r=s.sourceMap;r&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(r))))," */")),e.styleTagTransform(i,t,e.options)}(e,t,s)},remove:function(){!function(t){if(null===t.parentNode)return!1;t.parentNode.removeChild(t)}(e)}}}},4589:t=>{"use strict";t.exports=function(t,e){if(e.styleSheet)e.styleSheet.cssText=t;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(t))}}},7241:(t,e,s)=>{"use strict";s.d(e,{D:()=>c});var i=s(4469),n=s(976),r=s(6414),o=s.n(r),a=s(2140),l=s(499);const h=31;async function c(t,e=!1,s){const r=l.Cn.getOrCreate(t);let c;s??(s=new Map);const m=r.isHelm()?(0,a.getHelmMonomers)(t):Object.keys(r.stats.freq).filter((t=>""!==t));for(let t=0;t<m.length;t++)s.has(m[t])||s.set(m[t],`${s.size+1}`);if(r.isHelm())c=await i.functions.call("HELM:getMolFiles",{col:t}),c=function(t,e,s=!1){const i=new Array(t.length);for(let n=0;n<t.length;n++){let r=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=t.get(n);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const c=parseInt(l.substring(r,r+3)),u=parseInt(l.substring(r+3,r+6));a+=`M V30 COUNTS ${c} ${u} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let t=0;t<c;t++){r=l.indexOf("\n",r)+1+h,o=l.indexOf(" ",r);const i=l.substring(r,o);a+=s?`M V30 ${t+1} R${e.get(i)} 0.000 0.000 0 0\n`:`M V30 ${t+1} At 0.000 0.000 0 0 MASS=${e.get(i)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let t=0;t<u;t++){r=l.indexOf("\n",r)+1;const e=parseInt(l.substring(r,r+3).trim()),s=parseInt(l.substring(r+3,r+6).trim());a+=`M V30 ${t+1} ${parseInt(l.substring(r+6,r+9).trim())} ${e} ${s}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",i[n]=a}return i}(c,s,e);else{c=new Array(t.length);for(let i=0;i<t.length;i++){const t=u(o()(r.splitted[i]).filter((t=>""!==t)).toArray(),s,e);c[i]=t}}return n.Column.fromStrings("monomericMols",c)}function u(t,e,s=!1){let i="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";i+=`M V30 COUNTS ${t.length} ${t.length?t.length-1:0} 0 0 0\n`,i+="M V30 BEGIN ATOM\n";for(let n=0;n<t.length;n++)i+=s?`M V30 ${n+1} R${e.get(t[n])} 0.000 0.000 0 0\n`:`M V30 ${n+1} At 0.000 0.000 0 0 MASS=${e.get(t[n])}\n`;i+="M V30 END ATOM\n",i+="M V30 BEGIN BOND\n";for(let e=0;e<t.length-1;e++)i+=`M V30 ${e+1} 1 ${e+1} ${e+2}\n`;return i+="M V30 END BOND\n",i+="M V30 END CTAB\n",i+="M END",i}},2140:(t,e,s)=>{"use strict";s.r(e),s.d(e,{SeqActivityCliffsEditor:()=>Ye,SeqPaletteCustom:()=>_e,SequenceSpaceEditor:()=>qe,SplitToMonomersEditor:()=>rs,SubsequenceSearchTopMenu:()=>ds,_package:()=>Ne,activityCliffs:()=>ze,addCopyMenu:()=>bs,alignSequences:()=>je,bioSubstructureFilter:()=>ys,compositionAnalysis:()=>Je,compositionAnalysisWidget:()=>He,convertDialog:()=>ss,demoBioActivityCliffs:()=>Ss,demoBioAtomicLevel:()=>Ms,demoBioHelmMsaSequenceSpace:()=>As,demoBioSequenceSpace:()=>Cs,demoBioSimilarityDiversity:()=>vs,diversitySearchTopMenu:()=>us,diversitySearchViewer:()=>cs,fastaSequenceCellRenderer:()=>Fe,getBioLib:()=>ke,getHelmMonomers:()=>as,getMonomerLibHelper:()=>Le,hydrophobPalette:()=>Ie,importBam:()=>es,importFasta:()=>ts,initBio:()=>Re,libraryPanel:()=>Pe,macroMolColumnPropertyPanel:()=>We,macromoleculeDifferenceCellRenderer:()=>De,monomerCellRenderer:()=>is,multipleSequenceAlignmentDialog:()=>$e,packageSettingsEditor:()=>Ge,saveAsFasta:()=>fs,sdfToJsonLib:()=>Qe,searchSubsequenceEditor:()=>ms,separatorSequenceCellRenderer:()=>Ve,sequenceAlignment:()=>Be,sequenceIdentityScoring:()=>ps,sequenceSimilarityScoring:()=>gs,sequenceSpaceTopMenu:()=>Xe,sequenceTooltip:()=>Oe,similaritySearchTopMenu:()=>hs,similaritySearchViewer:()=>ls,splitToMonomersTopMenu:()=>os,testDetectMacromolecule:()=>ns,toAtomicLevel:()=>Ke,vdRegionsViewer:()=>Ze,webLogoLargeApp:()=>ws,webLogoViewer:()=>Ue});var i=s(4469),n=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(6066);const h="rgb(100,100,100)",c="#808080",u="rgb(0,0,0)",m=l.GU;var d;function p(t,e,s,i,n,r,o=h,a=0,l=!1,p=1,g="",f=!1,y=d.classic,w=[],b=0,v=null,C=[],S=null,M={}){n.textAlign="start";let A=r.substring(0),T=f?"":g;y===d.MSA&&(T="");let E=!0,x=!0,N="difference";null!=v&&null!=v.cell.column&&(E=v.cell.column.temp["color-code"]??!0,x=v.cell.column.temp["compare-with-current"]??!0,N=v.cell.column.temp["highlight-difference"]??"difference");const L=C[b];x&&C.length>0&&"difference"===N&&(p=A==L?.3:p),x&&C.length>0&&"equal"===N&&(p=A!=L?.3:p),null!=S&&(A=m(A,S));const I=A+T;M[I]??(M[I]=n.measureText(I));let _=M[I];M[A]??(M[A]=n.measureText(A));let R=M[A].width;M[T]??(M[T]=n.measureText(T));const O=M[T].width,k=i/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function P(s,i){const r=E?o:u;n.fillStyle=r,n.globalAlpha=p,y===d.classic&&(n.fillText(A,t+s,e+k),n.fillStyle=c,n.fillText(T,t+i,e+k)),y===d.MSA&&n.fillText(A,t+s,e+k)}_=_.width,y===d.MSA&&(R=w[b],_=w[b]);const G=(w[b]??0)-(w[0]??0);if(l||_>s)return P(G,G+R),t+G+R+O;{const e=(s-_)/2;return P(e,e+R),t+G+e+R}}!function(t){t.MSA="MSA",t.classic="classic"}(d||(d={}));var g,f=s(9611),y=s(8447),w=s(7331),b=s(499);!function(t){t.long="long",t.short="short"}(g||(g={}));const v={true:"1",false:"0"};var C=s(3553);const S="rgb(100,100,100)",M=y.GU;function A(t,e,s,i){return t?Math.min(t.canvas.width-s,i):e.canvas.width-s}function T(t){const e=!a().enumerate(t).some((([e,s])=>e.length>1&&0!=s&&s!=t.length-1)),s=[],i=e?"":" ";for(const[e,n]of a().enumerate(t)){let r=e;n<t.length&&(r+=`${e?"":"-"}${i}`),s.push(r)}return[s,e]}class E extends r.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const r=t.bounds,o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=s.getPosition(t.tableRowIndex,o),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],r=[n.div(t)];if(s._monomerStructureMap[t])r.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const n={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=i.chem.svgMol(e.smiles,void 0,void 0,n);r.push(o),s._monomerStructureMap[t]=o}}n.tooltip.show(n.divV(r),e.x+16,e.y+16)}else n.tooltip.hide()}render(t,e,s,i,n,o,l){let h=0,c=999;const u=o.grid,m=o.cell.column,g=m.temp,w=g["monomer-width"];"short"===(null!=w?w:"short")&&(c=g[".mm.cellRenderer.maxMonomerLength"]??Ne.properties.MaxMonomerLength);let C=m.temp["bio-seqCol"];C||(C=new f.A(u,m,(()=>{const t=b.Cn.getOrCreate(m);return{unitsHandler:t,monomerCharWidth:7,separatorWidth:t.isMsa()?8:h,monomerToShort:M,monomerLengthLimit:c,monomerLib:ke()}}))),m.tags[".mm.cellRenderer.settingsChanged"]===v.true&&(h=g[".mm.cellRenderer.gapLength"]??h,C.setMonomerLengthLimit(c),C.setSeparatorWidth(C.isMsa()?8:h),m.setTag(".mm.cellRenderer.settingsChanged",v.false));const[T,E]=C.getCellMonomerLengths(o.tableRowIndex);T.length,C.updated&&(g["bio-seqCol"]=C),t.save();try{const l=-1!==o.gridRow?o.grid:null,h=o.cell.value,u=m.getTag("alphabet"),f=50;i=A(l,t,e,i),t.beginPath(),t.rect(e+this.padding,s+this.padding,i-this.padding-1,n-2*this.padding),t.clip(),t.font="12px monospace",t.textBaseline="top";const w=m.getTag(r.TAGS.UNITS),v=m.getTag("aligned"),M=(0,y.py)(u),T=m.getTag("separator")??"",x=i/5,N=b.Cn.getOrCreate(m).getSplitter(x),L=g["reference-sequence"],I=g["current-word"],_=N(null!=L&&""!=L?L:I??""),R=N(h);let O=S,k=d.classic;v&&v.includes("MSA")&&w==y.r2.SEPARATOR&&(k=d.MSA);for(const[r,l]of a().enumerate(R)){O=M.get(r),t.fillStyle=S;const a=l===R.length-1;if(p(e+this.padding,s,i,n,t,r,O,0,!0,1,T,a,k,E,l,o,_,c,C._monomerLengthMap),f>i)break}}catch(t){const e=t instanceof Error?t.message:t?t.toString():"Error 'undefined'";Ne.logger.error(`Bio: MacromoleculeSequenceCellRenderer.render() error: ${e}`)}finally{t.restore()}}}class x extends r.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return C.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,i,n,o,a){const h=o.grid,c=o.cell,u=o.tableColumn,m=c.value??"",d=u.tags.separator,p=u.tags[r.TAGS.UNITS];i=A(h,t,e,i);const[g,f]=m.split("#"),y=(0,l.vU)(p,d);N(t,e,s,i,n,y(g),y(f),p)}}function N(t,e,s,i,n,r,o,l,h,c){if(r.length!==o.length){const t=function(t,e){let s=0,i=0;const n=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)n[t]===r[t]&&s++;const o=n.length-r.length;for(let t=n.length-1;t>o;t--)n[t]===r[t-o]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(a()(r).toArray(),a()(o).toArray());r=t.subParts1,o=t.subParts2}const u=t.measureText(T(r).join("")),m=t.measureText(T(o).join("")),d=Math.max(u.width,m.width);h&&(i=d+4*r.length,t.canvas.width=d+4*r.length);let g=Math.max(e,e+(i-(d+4*r.length))/2)+5;const f=Math.max(s,s+(n-28)/2);t.save(),t.beginPath(),t.rect(e,s,h?d+4*r.length:i,n),t.clip(),t.font="12px monospace",t.textBaseline="top";let b=w.UE.Color;"HELM"!=l&&(b=(0,y.py)(l.substring(l.length-2)));for(let e=0;e<r.length;e++){const s=r[e],a=o[e],l=b.get(s);if(s!=a){const r=b.get(a),o=p(g,f-7,i,n,t,s,l,0,!0),h=p(g,f+7,i,n,t,a,r,0,!0);g=Math.max(h,o),c&&(c[e]=L(s,a,l,r,f,7,n))}else g=p(g,f,i,n,t,s,l,0,!0,.5);g+=4}t.restore()}function L(t,e,s,i,n,r,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const h=l.measureText(T([t]).join("")).width,c=l.measureText(T([e]).join("")).width,u=Math.max(h,c);return a.height=o,a.width=u+4,l.font="12px monospace",l.textBaseline="top",p(0,n-r,u,o,l,t,s,0,!0),p(0,n+r,u,o,l,e,i,0,!0),a}var I,_=s(701),R=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(I||(I={})),new class{constructor(){this.regionTypes=[I.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.positionWidth=16,this.positionHeight=R.ES.Entropy}};var O=s(833);const k=I;var P,G;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(P||(P={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.positionWidth="positionWidth",t.positionHeight="positionHeight"}(G||(G={}));class F extends r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.skipEmptyPositions=this.bool(G.skipEmptyPositions,!1,{category:P.DATA}),this.regionTypes=this.stringList(G.regionTypes,[k.CDR],{category:P.DATA,choices:Object.values(k).filter((t=>t!=k.Unknown))}),this.chains=this.stringList(G.chains,["Heavy","Light"],{category:P.DATA,choices:["Heavy","Light"]}),this.positionWidth=this.float(G.positionWidth,16,{category:P.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position. A value of zero means autofit to the width."}),this.positionHeight=this.string(G.positionHeight,R.ES.Entropy,{category:P.LAYOUT,choices:Object.keys(R.ES)})}async init(){this.subs.push((0,_.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){if(this.setDataInProgress)return;const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}onTableAttached(){super.onTableAttached(),this.setData(this.dataFrame,this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case G.regionTypes:case G.chains:this.setData(this.dataFrame,this.regions)}switch(t.name){case G.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[O.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case G.positionWidth:this.calcSize();break;case G.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[O.bo.positionWidth]:this.positionWidth});this.calcSize();break;default:this.setData(this.dataFrame,this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){this.setDataInProgress||(this.setDataInProgress=!0,Ne.logger.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.regions=e,this.dataFrame.dart!==t.dart&&(this.dataFrame=t)})).then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)})).catch((t=>{const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ne.logger.error(e,void 0,s)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(t){Ne.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&n.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Ne.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<s.length;t++)for(const n of this.chains){const r=e.find((e=>e.order==s[t]&&e.chain==n));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,n,e]})())}const r=await Promise.all(i);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of r)this.logos[t][e]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=n.table(this.chains,(t=>[...s.length>0?[n.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",n.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=n.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",n.tooltip.bind(this.filterSourceInput.input,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=n.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Ne.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){Ne.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let s=0;s<this.logos.length;s++){for(const e of this.chains)this.logos[s][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[s][t].Length)))}if(0===this.positionWidth){if(this.logos.length>0&&e>0){const t=22,s=13,i=9,n=(this.root.clientWidth-t-(this.logos.length-1)*i-s)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const s=this.logos[t][e];s.setOptions({[O.bo.positionWidth]:n}),s.root.style.width=n*s.Length+"px"}}}else for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[O.bo.positionWidth]:this.positionWidth});0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?R.Ct.Selected:R.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let s=0;s<this.chains.length;s++){const i=this.chains[s];this.logos[e][i].setOptions({[O.bo.filterSource]:t})}}}var W=s(9017),H=s(7656),V=s(7983),D=s(7767),B=s(489);async function U(t){const e=new D.L(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let s=B.U.LEVENSHTEIN,i=t.seqCol.toList();if(e.isSeparator()){const t=e.convert(y.r2.FASTA);i=t.toList(),s=b.Cn.getOrCreate(t).getDistanceFunctionName()}else s=e.getDistanceFunctionName();for(let e=0;e<i.length;e++)i[e]=t.seqCol.isNone(e)?null:i[e];const n=await(0,H.I)(i,t.methodName,s,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,n.embedding[e])));return{distance:n.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,V.HV)(t.seqCol,!1),await i.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function Z(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var Y=s(5697),z=s(3379),q=s.n(z),X=s(7795),K=s.n(X),$=s(569),j=s.n($),J=s(3565),Q=s.n(J),tt=s(9216),et=s.n(tt),st=s(4589),it=s.n(st),nt=s(9414),rt={};rt.styleTagTransform=it(),rt.setAttributes=Q(),rt.insert=j().bind(null,"head"),rt.domAPI=K(),rt.insertStyleElement=et(),q()(nt.Z,rt),nt.Z&&nt.Z.locals&&nt.Z.locals;var ot=s(3914),at=s(6254);let lt=0;const ht="cliffsDf",ct=new _.Subject,ut="act_diff",mt="sali",dt="sim",pt="line_index",gt=["1_seq","2_seq"],ft="filterCliffs";function yt(t,e,s){const i=e.getBoundingClientRect(),n=t.clientX-i.left,r=t.clientY-i.top;let o=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-n,t.a[1]-r)+Math.hypot(t.b[0]-n,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var wt=s(1040);async function bt(t,e,s,n,o){e.version!==e.temp["last-invalidated-version"]&&await(0,V.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(n).init((t=>e.temp["monomeric-mols"].get(t))),await i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:n,simArr:o})}function vt(t){const e=n.divH([]),s=n.divV([n.divText(t.seqCol.name),n.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,i)=>{const r=n.divText(t.activityCol.get(s).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(n.divV([n.divText(t.seqCol.get(s)),r]))})),e}function Ct(t){const e=n.div();e.append(n.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),i=new Array(2);t.line.mols.forEach(((e,n)=>{s[n]=t.seqCol.get(e),i[n]=t.activityCol.get(e)}));const r={},o=b.Cn.getOrCreate(t.seqCol),a=o.getSplitter(),l=Mt(a(s[0]),a(s[1]),o.units,r);return e.append(n.div(l,{style:{width:"300px",overflow:"scroll"}})),e.append(At(r)),e.append(St("Activity delta",Math.abs(i[0]-i[1]))),e.append(St("Cliff",t.sali)),e}function St(t,e){return n.divH([n.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),n.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function Mt(t,e,s,i){const n=document.createElement("canvas"),r=n.getContext("2d");return n.height=30,N(r,0,0,0,30,t,e,s,!0,i),n}function At(t){const e=n.div();if(Object.keys(t).length>0){const s=n.divV([]);s.append(n.divH([n.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),n.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(n.divH([n.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function Tt(t,e){const s=r.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}s(7861);var Et=s(4004),xt=s(7228),Nt=s(6375),Lt=s(5226);s(9133);class It extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",Y.kg[0],{choices:Y.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((async t=>await this.render())));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((async e=>await this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((async t=>await this.render(!1)))),this.subs.push(r.debounce(n.onSizeChanged(this.root),50).subscribe((async t=>await this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}await this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}async render(t=!0){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var _t=s(7241),Rt=s(4293),Ot=s(2669);async function kt(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=b.Cn.getOrCreate(t).getDistanceFunctionName(),i=new Ot.m(!0,!1),n=await i.calc(e,s);return i.terminate(),n}function Pt(t){return(e,s)=>{const i=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?i(e,s):i(s,e)}}class Gt extends It{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new _.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async render(t=!0){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=b.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const n=s.plot.grid();n.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));n.cell("score",o).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Rt.Y)(this.root,n.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,_t.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await kt(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const i=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const n=b.Cn.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),i.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(i.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const r=Math.floor(s*i.length/o),u=s===a.length-1?Math.floor((s+1)*i.length/o):i.length;return new Promise(((s,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:i,max:n}})=>{t?o(t):(h=Math.min(h,i),c=Math.max(c,n),l.set(e,r),s())},t.postMessage({fnName:n,values:i,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,i=Pt(e),n=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[i(this.targetMoleculeIdx,s)]:1-t[s]})));n.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=n.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=n.div(),s={},r=this.molCol?.name,o=t.col(r),a=b.Cn.getOrCreate(o),l=a.getSplitter(),h=l(this.moleculeColumn.get(this.targetMoleculeIdx)),c=l(t.get(r,t.currentRowIdx)),u=Mt(h,c,a.units,s);e.append(n.div(u,{style:{width:"300px",overflow:"scroll"}})),h.length!==c.length&&e.append(n.divV([n.divText("Different sequence length:",{style:{fontWeight:"bold"}}),n.divText(`target: ${h.length} monomers`),n.divText(`selected: ${c.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(At(s));const m=n.accordion(),d=n.element("i");d.className="grok-icon svg-icon svg-view-layout",m.addTitle(n.span([d,n.label("Similarity search")])),m.addPane("Differences",(()=>e),!0),i.shell.o=m.root}}var Ft=s(8518);class Wt extends It{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new _.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async render(t=!0){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=b.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const i=r.DataFrame.fromColumns([s]);i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Rt.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,_t.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await kt(this.moleculeColumn),e=this.moleculeColumn.length,s=Pt(e);this.renderMolIds=(0,Ft.L)(e,Math.min(e,this.limit),((e,i)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(i)?0:t[s(e,i)]))}}var Ht=s(9943),Vt=s(4413),Dt=s(1061),Bt=s(1345),Ut=s(116);const Zt={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class Yt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=n.inputs([]),this.methodsParams={[Ut.AL.UMAP]:new Ut.bD,[Ut.AL.T_SNE]:new Ut.aP},this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=n.columnInput(Zt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=n.choiceInput("Method",Ut.AL.UMAP,[Ut.AL.UMAP,Ut.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=n.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):n.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=n.inputs([]);let e=!1;this.similarityMetricInput=n.choiceInput("Similarity",wt.gk.Tanimoto,Y.Rt)}createAlgorithmSettingsDiv(t,e){return n.empty(t),Object.keys(e).forEach((s=>{const i=e[s],r=n.floatInput(i.uiName,i.value,(()=>{i.value=r.value}));n.tooltip.bind(r.root,i.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=n.columnInput(Zt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),n.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class zt extends Yt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=n.boolInput("Plot Embeddings",!0),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class qt extends Yt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=n.intInput("Similarity cutoff",80),n.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),n.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Xt,Kt=s(8457);async function $t(t,e,s,i){const n=(0,Kt.O)(e),o=(0,l.vU)(e.getTag(r.TAGS.UNITS),e.getTag("separator"))(s),a=i===Xt.IDENTITY?function(t,e){const s=e.columns.length,i=new Array(s),n=new Array(s),o=new Array(s);for(let r=0;r<s;++r){const s=e.columns.byIndex(r);i[r]=s.getRawData(),n[r]=s.categories.indexOf(""),o[r]=s.categories.indexOf(t[r]??"")}const a=r.Column.float("Identity",e.rowCount),l=a.getRawData();for(let s=0;s<e.rowCount;++s){l[s]=0;for(let e=0;e<t.length;++e)i[e][s]===o[e]&&++l[s];l[s]/=t.length}return a}(o,n):i===Xt.SIMILARITY?await async function(t,e){const s=e.columns.toList();return await(0,xt.Qx)(s,t)}(o,n):null;if(null===a)throw new Error(`In bio library: Unkown sequence scoring method: ${i}`);return a.name=t.columns.getUnusedName(a.name),t.columns.add(a),a}!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(Xt||(Xt={}));var jt,Jt=function(t,e,s,i){return new(s||(s=Promise))((function(n,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?n(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};class Qt{constructor(t,e,s=!1,i){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._stopStartBtn=n.button(n.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=n.button(n.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=n.button(n.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._closeBtn=n.button(n.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Qt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=n.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(n.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=n.iconFA("clock");this._isAutomatic||0===e&&(s=n.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const i=n.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=n.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=n.divH([s,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,s;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const n=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,n,""),(null===(e=null===(t=n.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=n.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return Jt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,i,a),yield(0,Dt.gw)(a));const l=n.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=n.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Jt(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return Jt(this,void 0,void 0,(function*(){const i=n.div([],"demo-script-countdown");e.classList.add("hidden");let r=s/1e3;const o=this._createSVGIndicator(r);i.append(o),t.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Qt.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return Jt(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function te(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ne.logger.error(t.message,void 0,s)}Qt.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(jt||(jt={}));const ee="data/sample_FASTA_PT_activity.csv";var se=s(1811);async function ie(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function ne(){return await i.functions.call("Dendrogram:getDendrogramService",{})}const re="data/sample_FASTA_PT_activity.csv",oe="sequence";var ae=s(3336),le=s.n(ae);const he="data/sample_FASTA_PT_activity.csv";var ce=s(8341);const ue="samples/HELM.csv";var me=s(2568),de=s(525);class pe{constructor(t){this.urlParams=t,this._funcName=""}async init(t,e){this._funcName=e,this.df=t,await this.buildView()}async buildView(){const t=a()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Ne.name}.${this._funcName}?${t}`;const e={sequenceColumnName:"sequence"};for(const[t,s]of this.urlParams.entries())switch(t){case O.bo.fixWidth:case O.bo.fitArea:e[t]=["1","on","true"].includes(s.toLowerCase());break;default:e[t]=s}const s=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ge{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=n.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=n.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=n.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var fe=s(9416);class ye{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const we=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},be={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class ve{constructor(t){this.gridCol=t,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.gridCol.grid.dart||t.gridColumn.dart!=this.gridCol.dart||!t.tableColumn||!t.isTableCell)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new ye(Le().getBioLib()).getCappedRotatedMonomer(a,o),h=n.div(o),c=l?i.chem.svgMol(l,void 0,void 0,be):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return n.tooltip.show(n.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){let e=t.temp[we.tooltipHandlerTemp];return e||(e=t.temp[we.tooltipHandlerTemp]=new ve(t)),e}}class Ce extends r.GridCellRenderer{get name(){return C.Of.MONOMER}get cellType(){return C.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,i,n,r,o){if(r.gridRow<0)return;ve.getOrCreate(r.gridColumn),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,y.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,y.GU)(l,6),e+i/2,s+n/2,i)}}class Se extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new _.Subject}}class Me extends r.Package{get properties(){return this._properties}set properties(t){this._properties=t}}class Ae extends r.Widget{constructor(t){super(n.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=n.intInput("Max monomer length",Ne.properties.MaxMonomerLength,(t=>{Ne.properties.MaxMonomerLength=t})),e=n.boolInput("Tooltip WebLogo",Ne.properties.TooltipWebLogo,(t=>{Ne.properties.TooltipWebLogo=t})),s=n.choiceInput("Default Separator",Ne.properties.DefaultSeparator,[".","/","-"],(t=>{Ne.properties.DefaultSeparator=t}));this.root.appendChild(n.form([t,e,s]))}}var Te=s(5362),Ee={};Ee.styleTagTransform=it(),Ee.setAttributes=Q(),Ee.insert=j().bind(null,"head"),Ee.domAPI=K(),Ee.insertStyleElement=et(),q()(Te.Z,Ee),Te.Z&&Te.Z.locals&&Te.Z.locals;class xe extends r.Widget{constructor(t){super(n.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=b.Cn.getOrCreate(this.seqCol),e=Ne.properties.TooltipWebLogo,s=this.seqCol.getTag(R.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}const Ne=new Me;function Le(){return Bt.NT.instance}let Ie=null;class _e{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function Re(){let t;await Promise.all([(async()=>{await Bt.NT.instance.loadLibraries()})(),(async()=>{t=await i.functions.call("Chem:getRdKitModule")})(),(async()=>{const t=await Ne.getProperties(),e=new Se(t);Ne.properties=e})()]);const e=Bt.NT.instance.getBioLib(),s=[],n=[],r=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((e=>{s.push(e);const i=r[e].replaceAll("#R","O "),o=t.get_mol(i),a=JSON.parse(o.get_descriptors()).CrippenClogP;n.push(a),o?.delete()}));const o=n.reduce(((t,e)=>t+e),0)/n.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=n[t]<o?"#4682B4":"#DC143C";Ie=new _e(a)}function Oe(t){const e=new xe(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();i.shell.error(e)})),e}function ke(){return Bt.NT.instance.getBioLib()}async function Pe(t){return(0,Bt.cf)()}function Ge(t){const e=new Ae(t);return e.init().then(),e}function Fe(){return new E}function We(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===r.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=n.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:g.short,[g.short,g.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const i=n.intInput("Max monomer length",t.temp[".mm.cellRenderer.maxMonomerLength"]??Ne.properties.MaxMonomerLength,(e=>{t.temp[".mm.cellRenderer.maxMonomerLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));i.setTooltip(`The max length of monomer name displayed without shortening in '${g.short}' monomer width mode.`);const o=n.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));o.setTooltip("The size of margin between monomers (in pixels)");const a=n.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));a.setTooltip("Color code");const l=n.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const h=n.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip('When on, all sequences get rendered in the "diff" mode');const c=n.inputs([s,i,o,l,a,h]);return new r.Widget(c)}(t)}function He(t){return function(t){const e=n.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let i=w.UE.Color;switch(s){case"DNA":case"RNA":i=(0,y.py)("DNA");break;case"PT":i=(0,y.py)("PT")}const o=new Map;let l=0;const h=b.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),c=h.length;a()(h).filter((t=>!!t&&""!==t)).forEach((t=>{const e=o.get(t)||0;o.set(t,e+1),l=Math.max(l,e+1)})),l/=c;const u={},m=Array.from(o.entries());m.sort(((t,e)=>e[1]-t[1])),m.forEach((([t,e])=>{const s=e/c,r=i.get(t),o=n.div("",{classes:"macromolecule-cell-comp-analysis-bar"});o.style.width=s/l*50+"px";const a=n.div((100*s).toFixed(2)+"%");o.style.backgroundColor=r,u[t]=n.div([o,a],{classes:"macromolecule-cell-comp-analysis-value"})}));const d=n.tableFromMap(u);return Array.from(d.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(d),new r.Widget(e)}(t)}function Ve(){return new E}function De(){return new x}function Be(t,e,s,i,n){const r=new W.k(i,n,s,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunch()}function Ue(){return new O.OZ}function Ze(){return new F}function Ye(t){const e=new qt(r.SEMTYPE.MACROMOLECULE);n.dialog({title:"Activity Cliffs"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}async function ze(t,e,o,a,l,h){if(!(0,me.n)(e,"Activity Cliffs"))return;const c=Z(t),u={units:e.getTag(r.TAGS.UNITS),aligned:e.getTag("aligned"),separator:e.getTag("separator"),alphabet:e.getTag("alphabet")},m=new D.L(e);let d=wt.gk.Tanimoto,p=e;if(m.isFasta()||m.isSeparator()&&m.alphabet&&"UN"!==m.alphabet)if(m.isFasta())d=m.getDistanceFunctionName();else{p=m.convert(y.r2.FASTA);const t=b.Cn.getOrCreate(p);d=t.getDistanceFunctionName(),u.units=y.r2.FASTA}const g=async()=>await async function(t,e,o,a,l,h,c,u,m,d,p,g,f,y,w,b,v,C){lt++;const S=c/100,M=o??e;let A=!1,T=!1;const E={};let x,N;const L={seqCol:M,methodName:m,similarityMetric:u,embedAxesNames:a,options:v},{distance:I,coordinates:_}=await g(L);for(const e of _)t.columns.add(e);let R=I;const O=Object.values(B.U).map((t=>t.toString())).includes(u);O&&!I&&(R=ot.H.calc(e.toList(),B.o[u]()).data);const k=function(t,e,s){const i=[],n=[],r=[],o=[],a=new Set;for(let l=0;l!=t.length;++l)for(let h=0;h!=t.length-l;++h){const c=t[l]?t[l].get(h):0;if(c>=e){r.push(l),o.push(l+h+1),a.add(l),a.add(l+h+1),i.push(c);const t=Math.abs(s.get(l)-s.get(l+h+1));n.push(1!=c?t/(1-c):1/0)}}return{simVals:i,saliVals:n,n1:r,n2:o,cliffsMolIds:a}}(await async function(t,e,s,i){const n=t.categories,o=t.getRawData(),a=r.Column.string("seq",t.length).init((t=>n[o[t]])),l=r.DataFrame.fromColumns([a]),h=t.length;let c=Array(h-1);return s&&e?function(t,e,s){const i=(0,at.y)(t);for(let n=0;n<t-1;++n){const o=new Float32Array(t-n-1).fill(0);for(let s=n+1;s<t;++s){const t=i(n,s);o[s-n-1]=e[t]===r.FLOAT_NULL?0:(0,Y.Om)(e[t])}s[n]=r.Column.fromFloat32Array("similarity",o)}}(h,e,c):c=await i(h,t,l,"seq",c),c}(M,R,O,f),S,h),P=function(t,e,s,i,n,o){const a=new Array(t).fill(0);for(let t=0;t!=s.length;++t)e[t]!=1/0&&(o.get(s[t])>o.get(i[t])?a[s[t]]+=e[t]:a[i[t]]+=e[t]);return r.Column.fromList("double",`sali_${n[0].substring(n[0].lastIndexOf("_"))}`,a)}(M.length,k.saliVals,k.n1,k.n2,a,h);t.columns.add(P);const G=function(t,e){const s="containsCliff",i=t.columns.names().filter((t=>t.includes(s))).length+1,n=`${s}_${i}`;return r.Column.bool(n,t.rowCount).init((t=>e.has(t)))}(t,k.cliffsMolIds);t.columns.add(G);const F=function(t){const e=t.filter((t=>t!==1/0)),s=Math.min(...e);return{max:Math.max(...e),min:s}}(k.saliVals),W=.8/(F.max-F.min),H=i.shell.getTableView(t.name);H.grid.columns.byName(G.name).visible=!1;const V=H.addViewer(r.VIEWER.SCATTER_PLOT,{xColumnName:a[0],yColumnName:a[1],size:P.name,color:h.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:l}),D=V.getInfo().canvas,U=function(t,e,s,i,n){const o=new Array(t.n1.length).fill(null);for(let e=0;e<t.n1.length;e++){const s=t.n1[e],i=t.n2[e];o[e]={id:e,mols:[s,i],selected:!1,a:[],b:[]}}const a=r.DataFrame.create(o.length);return gt.forEach(((t,s)=>{a.columns.addNewString(t).init((t=>e.get(o[t].mols[s]))),function(t,e){Object.keys(e).forEach((s=>{t.tags[s]=e[s]}))}(a.col(t),n),a.col(t).semType=i})),a.columns.addNewFloat(ut).init((t=>Math.abs(s.get(o[t].mols[0])-s.get(o[t].mols[1])))),a.columns.addNewInt(pt).init((t=>t)),a.columns.addNewFloat(mt).init((e=>t.saliVals[e])),a.columns.addNewFloat(dt).init((e=>t.simVals[e])),a.name=`${ht}${lt}`,{lines:o,linesDf:a}}(k,e,h,d,p),Z=b?b(U.linesDf,gt).sort([mt],[!1]):U.linesDf.plot.grid().sort([mt],[!1]);t.temp[".cliffsDfGrid"]=Z;const z=n.button(`${U.linesDf.rowCount} cliffs`,(()=>{H.dockManager.dock(Z,"down",null,"Activity cliffs",C??.2)}));z.classList.add("scatter_plot_link","cliffs_grid"),V.root.append(z);const q=n.switchInput("Show only cliffs",!1,(()=>{q.value?(V.dataFrame.setTag(ft,G.name),t.rows.match({[G.name]:!0}).filter(),ct.next(G.name)):(V.dataFrame.setTag(ft,""),t.filter.setAll(!0,!0),ct.next(""))}));q.root.classList.add("scatter_plot_link","show_only_cliffs"),V.root.append(q.root),ct.subscribe((t=>{q.enabled=""===t||t===G.name}));const X=i.events.onViewerClosed.subscribe((t=>{t.args.viewer===V&&(H.dockManager.close(Z.root),X.unsubscribe(),H.subs=H.subs.filter((t=>t!==X)))}));return H.subs.push(X),U.linesDf.onCurrentCellChanged.subscribe((()=>{A=!0;const s=U.linesDf.currentCol&&U.linesDf.currentCol.name===gt[1]?1:0,r=-1!==U.linesDf.currentRowIdx?U.lines[U.linesDf.currentRowIdx]:null;V.dataFrame.currentRowIdx=r?r.mols[s]:-1,V.dataFrame.filter.set(0,!U.lines[0].selected),V.dataFrame.filter.set(0,U.lines[0].selected),r&&setTimeout((()=>{!function(t,e,s,r,o,a,l,h){const c=e.getPane("Cliff Details");n.empty(c.root);const u=h({cashedData:s,line:r,df:t,seqCol:o,activityCol:a,sali:l});c.root.append(u),setTimeout((()=>{i.shell.o=e.root}),500)}(t,x,E,r,e,h,U.linesDf.get(mt,r.id),w);const s=V.dataFrame.getSortedOrder(H.grid.sortByColumns,H.grid.sortTypes);H.grid.scrollToCell(e.name,s.indexOf(V.dataFrame.currentRowIdx))}),1e3)})),U.linesDf.onSelectionChanged.subscribe((e=>{if(!1===U.linesDf.selection.anyTrue)U.lines.forEach((t=>{t.selected=!1}));else if(-1!==U.linesDf.mouseOverRowIdx){const t=U.lines[U.linesDf.mouseOverRowIdx];t.selected=!t.selected}setTimeout((()=>{const e=r.BitSet.create(t.rowCount);U.lines.forEach((t=>{t.selected&&t.mols.forEach((s=>{e.set(s,t.selected,!0)}))})),t.selection.copyFrom(e),H.grid.invalidate()}),300)})),t.onSelectionChanged.subscribe((e=>{T?T=!1:!1===t.selection.anyTrue&&"number"==typeof e&&(U.lines.forEach((t=>{t.selected=!1})),Z.dataFrame.selection.setAll(!1,!1),Z.invalidate())})),D.addEventListener("mousemove",(function(i){clearTimeout(N),N=s.g.setTimeout((function(){const s=yt(i,D,U.lines);s&&-1===t.mouseOverRowIdx&&n.tooltip.show(y({cashedData:E,line:s,df:t,seqCol:e,activityCol:h}),i.clientX,i.clientY)}),500)})),D.addEventListener("mousedown",(function(e){T=!0;const s=yt(e,D,U.lines);if(s&&-1===t.mouseOverRowIdx){e.ctrlKey?(s.selected=!s.selected,U.linesDf.selection.set(s.id,s.selected)):U.linesDf.currentRowIdx!==s.id&&(U.linesDf.currentRowIdx=s.id,t.currentRowIdx=s.mols[0],t.filter.set(0,!U.lines[0].selected),t.filter.set(0,U.lines[0].selected));const i=U.linesDf.getSortedOrder(Z.sortByColumns,Z.sortTypes);Z.scrollToCell(gt[0],i.indexOf(s.id))}})),V.onEvent("d4-before-draw-scene").subscribe((e=>{const s=function(t,e,s,i,n,r,o){const a=i.lines,l=t.getInfo().canvas.getContext("2d"),h=t.dataFrame.columns.byName(e),c=t.dataFrame.columns.byName(s);for(let e=0;e<a.length;e++){const s=t.worldToScreen(h.get(a[e].mols[0]),c.get(a[e].mols[0])),u=t.worldToScreen(h.get(a[e].mols[1]),c.get(a[e].mols[1]));a[e].a=[s.x,s.y],a[e].b=[u.x,u.y];const m=new Path2D;m.moveTo(a[e].a[0],a[e].a[1]);const d=a[e].selected?"255,255,0":"0,128,0",p=n[e]===1/0?1:.2+(n[e]-o)*r;l.strokeStyle=`rgba(${d},${p})`,l.lineWidth=a[e].id===i.linesDf.currentRowIdx?3:1,m.lineTo(a[e].b[0],a[e].b[1]),l.stroke(m)}return a}(V,a[0],a[1],U,k.saliVals,W,F.min);if(A){const t=s[U.linesDf.currentRowIdx];setTimeout((()=>{const{zoomLeft:e,zoomRight:s,zoomTop:i,zoomBottom:n}=function(t,e,s,i,n,r){const o=Math.abs(s-n),a=Math.abs(i-r),l=t/o,h=e/a,c=Math.min(l,h),u=t/c*5,m=e/c*5,d=(s<n?s:n)+o/2-u/2,p=(i>r?i:r)-a/2+m/2;return{zoomLeft:d,zoomRight:d+u,zoomTop:p,zoomBottom:p-m}}(V.viewport.width,V.viewport.height,V.dataFrame.get(a[0],t.mols[0]),V.dataFrame.get(a[1],t.mols[0]),V.dataFrame.get(a[0],t.mols[1]),V.dataFrame.get(a[1],t.mols[1]));V.zoom(e,i,s,n)}),300),A=!1}q.value?t.rows.match({[G.name]:!0}).filter():!0===q.enabled&&t.filter.setAll(!0,!1)})),V.addProperty("similarityLimit","double",S),x=function(){const t=n.accordion(),e=n.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(n.span([e,n.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>n.divText("Cliff has not been selected")),!0),i.shell.o=t.root,t}(),V}(t,p,null,c,"Activity cliffs",o,a,d,l,r.SEMTYPE.MACROMOLECULE,u,U,bt,vt,Ct,Tt,h),f=l===Ut.AL.UMAP?5e3:2e3;if(t.rowCount>2e4)i.shell.warning("Too many rows, maximum for sequence activity cliffs is 20000");else{if(!(t.rowCount>f))return await g();n.dialog().add(n.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),e=await g();return t.close(),e})).show()}}function qe(t){const e=new zt(r.SEMTYPE.MACROMOLECULE);n.dialog({title:"Sequence Space"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}async function Xe(t,e,s,o=wt.gk.Tanimoto,a,l){if(await(0,Dt.gw)(10),!(0,me.n)(e,"Sequence space"))return;const h=Z(t),c=r.DataFrame.fromColumns([e]).clone(),u=function(t,e){const s=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),i=[...e.getRawData()],n=[];let r=0;for(let e=0;e<t.rowCount;e++)s.includes(i[e])&&(t.rows.removeAt(e-r),n.push(e),r+=1);return n}(c,e),m={seqCol:c.col(e.name),methodName:s,similarityMetric:o,embedAxesNames:h,options:l},d=s===Ut.AL.UMAP?1e5:15e3,p=s===Ut.AL.UMAP?5e3:2e3;if(t.rowCount>d)i.shell.warning(`Too many rows, maximum for sequence space is ${d}`);else{if(!(t.rowCount>p))return g(await U(m));n.dialog().add(n.divText("Sequence space analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running Sequence space..."),e=await U(m);return t.close(),g(e)})).show()}function g(e){const s=e.coordinates;for(const e of s){const s=e.toList();u.forEach((t=>s.splice(t,0,null))),t.columns.add(r.Column.float(e.name,t.rowCount).init((t=>s[t])))}if(a)return i.shell.tableView(t.name).scatterPlot({x:h[0],y:h[1],title:"Sequence space"})}}async function Ke(t,e){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,me.n)(e,"To Atomic Level"))return;const s=(await Le()).getBioLib(),o=await(0,Nt.i0)(t,e,s);null!==o.col&&(t.columns.add(o.col,!0),await i.data.detectSemanticTypes(t)),o.warnings&&o.warnings.length>0&&i.shell.warning(n.list(o.warnings))}function $e(){(0,de.K)()}async function je(t=null,e=null){return(0,de.K)({col:t,clustersCol:e})}async function Je(){const t=i.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==r.SEMTYPE.MACROMOLECULE&&(b.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,me.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});i.shell.tv.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let o=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>b.Cn.getOrCreate(t).isMsa())),r=n.choiceInput("Column",i?i.name:t[0],t);n.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(n.div([r])).onOK((async()=>{const t=e.find((t=>t.name==r.value))??null;t&&await s(t)})).show()}else o=e[0];o&&await s(o)}else i.shell.error("Current table does not contain sequences")}async function Qe(t){(0,xt.Xk)(t)}function ts(t){return new Lt.i(t).importFasta()}function es(t){return console.log(t),[]}function ss(){const t=(0,Rt.B)()[0];(0,Et.O)(t)}function is(){return new Ce}async function ns(t){const e=r.TaskBarProgressIndicator.create("Test detectMacromolecule..."),s=(await i.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let n=0;const o=[];for(const a of s)try{const e=await i.dapi.files.readAsText(t+a.fullPath),s=r.DataFrame.fromCsv(e);for(const t of s.columns)await i.functions.call("Bio:detectMacromolecule",{col:t})===r.SEMTYPE.MACROMOLECULE&&o.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(r.TAGS.UNITS)}`})}catch(t){o.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{n+=1,e.update(100*n/s.length,`Test ${a.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=r.DataFrame.fromObjects(o);return a.name=`datasets_detectMacromolecule_${t}`,a}function rs(t){const e=new ge;n.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}async function os(t,e){await(0,fe.n)(t,e)}function as(t){const e=b.Cn.getOrCreate(t).stats;return Object.keys(e.freq)}function ls(){return new Gt}function hs(){const t=i.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function cs(){return new Wt}function us(){const t=i.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function ms(t){const e=(0,Rt.B)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new V.uH(e)}function ds(t){i.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),i.shell.tv.grid.scrollToCell(t,0)}async function ps(t,e,s){return $t(t,e,s,Xt.IDENTITY)}async function gs(t,e,s){return $t(t,e,s,Xt.SIMILARITY)}function fs(){(0,Ht.C2)()}function ys(){return new Vt.ST}async function ws(){const t=r.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new pe(t),s=await Ne.files.readCsv("data/sample_PT_100000x5.csv");await i.data.detectSemanticTypes(s),await e.init(s,"webLogoLargeApp")}finally{t.close()}}function bs(t,e){!function(t,e){const s=b.Cn.getOrCreate(t.column),n=Object.values(y.r2).filter((t=>t!==s.units));e.group("Copy").items(n,(e=>{const s=new D.L(t.column),n=e===y.r2.SEPARATOR?Ne.properties.DefaultSeparator:void 0,r=s.getConverter(e,n)(t.value);navigator.clipboard?(navigator.clipboard.writeText(r),i.shell.info(`Value of notation '${e}' copied to clipboard`)):i.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e)}async function vs(){await async function(){let t,e;try{const s=new Qt("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await s.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await Ne.files.readCsv(ee),t=i.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const s=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(s,r.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const s=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){te(t)}}()}async function Cs(){await async function(){let t,e,s,n,o;try{const a=new Qt("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[n,t,e]=await Promise.all([Ne.files.readCsv(re),ie(),ne()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,s,i){let n;{const t=Object.values(jt);for(let s=0;s<t.length;s++){const i=t[s];if(!e.col(i)){const n=s==t.length-1;e.columns.add(r.Column.float(i,e.rowCount),n)}}if(e.rowCount>=1){const i=e.getCol(s).toList(),n=Date.now();Ne.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await(0,H.I)(i,"UMAP",wt.W.Levenshtein,{}),o=Date.now();Ne.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-n)/1e3} s`);for(let s=0;s<t.length;s++){const i=t[s],n=e.getCol(i),o=r.embedding[s];n.init((t=>o[t]))}const a=Date.now();Ne.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}n=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:jt.X,yColumnName:jt.Y,lassoTool:!0})}return t.dockManager.dock(n,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),n}(s,n,oe)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const i=n.getCol(oe).toList(),r=ot.H.calc(i,((t,e)=>se.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{n.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=n.getCol("sequence_id");n.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),n.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){te(t)}}()}async function Ss(){await async function(){let t,e,s,n,o;const a=Ut.AL.UMAP;try{const l=new Qt("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([Ne.files.readCsv(he),ie(),ne()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=300,n.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await ze(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),n.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),le()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const i=s.getCol("sequence").toList(),r=ot.H.calc(i,((t,e)=>se.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(n.grid,o,void 0,150,void 0),n.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){te(t)}}()}async function Ms(){await async function(){const t="HELM";let e,s,o;try{await new Qt("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await Ne.files.readCsv("samples/HELM.csv"),s=i.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const i=s.grid.columns.byIndex(e);[t,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await Ke(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const i=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(i),o=n.dialog().add(a).show(),await(0,Dt.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){te(t)}}()}async function As(){await async function(){let t,e,s,n,o,a;const l="msa(HELM)",h=Ut.AL.UMAP;try{const c=new Qt("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=i.shell.addTableView(e=await Ne.files.readCsv(ue)),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=ce.J[0];n=await(0,ce.f)(s,l,t,1.53,0,void 0),e.columns.add(n),await i.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await Xe(e,n,h,B.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){te(t)}}()}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>r});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class n{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",i="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=r+s,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:r+s,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const n=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[n][e].parentJ}return new n(s,i,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let i=1;i<=this.len1;i++)for(let n=1;n<=this.len2;n++)this.fillOne(i,n),this.dpGrid[i][n].value<=0?(this.dpGrid[i][n].value=0,this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0):0==this.dpGrid[this.dpGrid[i][n].parentI][this.dpGrid[i][n].parentJ].value&&(this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0),this.dpGrid[i][n].value>t&&(t=this.dpGrid[i][n].value,e=i,s=n);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],this.BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]],this.NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]],this.PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]],this.PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]],this.PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]],this.TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]],this.CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23},this.CONNUCL={A:0,T:1,C:2,G:3},this.CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63},this.setMethod(i),this.setSequences(t,e),this.setGap(s)}}},7983:(t,e,s)=>{"use strict";s.d(e,{HV:()=>p,QF:()=>d,pf:()=>m,uH:()=>u});var i=s(4469),n=s(3870),r=s(976),o=s(7241),a=s(4293),l=s(1061),h=s(8447);const c="substr_helm";class u{constructor(t){this.col=t[0],this.createUI()}editHelmLinkAction(){(0,a.Y)(this.inputsDiv,this.grid.root),n.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(c,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const t=this.units===h.r2.HELM?n.divV([this.columnsInput,this.editHelmLink]):this.units===h.r2.SEPARATOR?n.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):n.inputs([this.columnsInput,this.substructureInput]);(0,a.Y)(this.inputsDiv,t)}updateNotationDiv(){this.units=this.col.getTag(r.TAGS.UNITS),this.separator=this.col.getTag("separator");const t=this.dialog.root.getElementsByClassName("notation-text")[0];t&&(t.textContent=`Notation: ${this.units}`)}createUI(){const t=i.shell.tv.dataFrame,e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.columnsInput=n.columnInput("Column",t,this.col,(t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()}),e),this.substructureInput=n.stringInput("Substructure",""),this.editHelmLink=n.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const s=r.DataFrame.create(1);s.columns.addNewString(c).init((t=>"")),s.col(c).semType=this.col.semType,s.col(c).setTag(r.TAGS.UNITS,h.r2.HELM),this.grid=s.plot.grid(),this.separatorInput=n.stringInput("Separator",this.separator),this.inputsDiv=n.div(),this.units=this.col.getTag(r.TAGS.UNITS),this.separator=this.col.getTag("separator"),this.updateInputs(),this.dialog=n.dialog("Substructure Search").add(n.divV([n.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,e=this.units===h.r2.HELM?s.get(c,0):this.substructureInput.value;this.units===h.r2.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(e=e.replaceAll(this.separatorInput.value,this.separator)),t=this.units===h.r2.HELM?await d(e,this.col):m(e,this.col),this.col.dataFrame.filter.and(t)})).show()}}function m(t,e,s){const i=s?function(t,e){const s=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=t.charAt(0)===e,n=t.charAt(t.length-1)===e,r=t.replace(new RegExp(`^${s}|${s}$`,"g"),"");return i?n?`${s}${r}${s}`:`${s}${r}${s}|${s}${r}$`:n?`^${r}${s}|${s}${r}${s}`:`^${r}${s}|${s}${r}${s}|${s}${r}$`}(t,s):t,n=r.BitSet.create(e.length);for(let s=0;s<e.length;s++){const r=e.get(s);(r.match(i)||r===t)&&n.set(s,!0,!1)}return n}async function d(t,e){e.version!==e.temp["last-invalidated-version"]&&await p(e,!0);const s=r.Column.string("helm",1).init((e=>t));s.semType=r.SEMTYPE.MACROMOLECULE,s.setTag(r.TAGS.UNITS,h.r2.HELM);const n=await(0,o.D)(s,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:n.get(0),molBlockFailover:""})).get(0)}async function p(t,e){const s=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);await(0,l.gw)(10);const i=new Map,n=await(0,o.D)(t,e,i);t.temp["monomeric-mols"]=n,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version,s.close()}},2568:(t,e,s)=>{"use strict";s.d(e,{n:()=>o});var i=s(4469),n=s(976),r=s(499);function o(t,e,s=[],o=[],a=!0){const[l,h]=function(t,e,s=[],o=[]){let a=!0,l="";const h=r.Cn.getOrCreate(t);if(t.semType!==n.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const t=h.notation;if(s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!h.isHelm()){const t=h.alphabet;o.length>0&&!o.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(t,e,s,o);return a&&!l&&i.shell.warning(h),l}},3553:(t,e,s)=>{"use strict";s.d(e,{Of:()=>r,WY:()=>h,jB:()=>c,rs:()=>a});var i,n,r,o,a,l=s(8341);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(n||(n={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(t){t.CELL_CHANGING="isCellChanging"}(o||(o={})),function(t){t.SEPARATOR="."}(a||(a={}));const h="3.3.1",c={pepsea:{gapOpen:1.53,gapExtend:0,method:l.J[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(t,e,s)=>{"use strict";s.d(e,{O:()=>m});var i=s(976),n=s(3870),r=s(4469),o=s(3336),a=s.n(o),l=s(8447),h=s(7767);let c=null,u=[];function m(t){let e=t??r.shell.t.columns.bySemType("Macromolecule");if(!e)throw new Error("No column with Macromolecule semantic type found");let s=new h.L(e),o=s.notation;const m=n.divText("Current notation: "+o,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),d=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],p=n.columnInput("Column",r.shell.t,e,(t=>{t.semType===i.SEMTYPE.MACROMOLECULE?(e=t,s=new h.L(e),o=s.notation,o===l.r2.HELM&&(y.value="/"),m.textContent="Current notation: "+o,f=d.filter((t=>t!==o)),b=n.choiceInput("Convert to",f[0],f,w),w(),c?.clear(),c?.add(n.div([m,p.root,b.root,y.root]))):p.value=e})),g=["-",".","/"];let f=d.filter((t=>t!==o));const y=n.choiceInput("Separator",g[0],g),w=()=>{b.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let b=n.choiceInput("Convert to",f[0],f,w);w(),b.onChanged((()=>{w()})),null==c&&(c=n.dialog("Convert Sequence Notation").add(n.div([m,p.root,b.root,y.root])).onOK((async()=>{const t=b.value,s=y.value??void 0;await async function(t,e,s){const i=new h.L(t).convert(e,s);t.dataFrame.columns.add(i);const n=await r.functions.call("Bio:detectMacromolecule",{col:i});return n&&(i.semType=n),await r.data.detectSemanticTypes(t.dataFrame),i}(e,t,s)})).show({x:350,y:100}),u.push(c.onClose.subscribe((t=>{u.forEach((t=>{t.unsubscribe()})),u=[],c=null}))))}},1345:(t,e,s)=>{"use strict";s.d(e,{NT:()=>w,cf:()=>f});var i=s(4469),n=s(3870),r=s(976),o=s(701),a=s(7228),l=s(2140);const h="Libraries",c="System:AppData/Bio/libraries/";async function u(){return await Promise.all((await i.dapi.files.list(c,!0,"")).map((async t=>t.fullPath.substring(c.length))))}let m=Promise.resolve();async function d(){let t;return m=m.then((async()=>{const e=await i.dapi.userDataStorage.getValue(h,"Settings",!0);t=e?JSON.parse(e):{exclude:[]},t.exclude=t.exclude instanceof Array?t.exclude:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await m,t}async function p(t){m=m.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),await i.dapi.userDataStorage.postValue(h,"Settings",JSON.stringify(t),!0)})),await m}async function g(){const t=n.dialog({title:"Manage files"}).add(n.fileBrowser({path:"System:AppData/Bio/libraries"}).root).addButton("OK",(()=>t.close())).show()}async function f(){const t=n.button("Manage",g),e=n.inputs([]),s=await u(),o=await d();for(const t of s){const s=n.boolInput(t,!o.exclude.includes(t),(()=>{1==s.value?o.exclude=o.exclude.filter((e=>e!=t)):o.exclude.includes(t)||o.exclude.push(t),p(o).then((async()=>{await w.instance.loadLibraries(!0),i.shell.info("Monomer library user settings saved.")}))}));e.append(s.root)}return new r.Widget(n.divV([e,n.div(t)]))}class y{constructor(t,e){this._monomers={},this._onChanged=new o.Subject,this._monomers=t,this.error=e}getMonomer(t,e){return t in this._monomers&&e in this._monomers[t]?this._monomers[t][e]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((s=>{e[s]=this._monomers[t][s].molfile})),e}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}get onChanged(){return this._onChanged}_updateInt(t){const e=t.getPolymerTypes(),s=this.getPolymerTypes();e.forEach((e=>{s.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((s=>{this._monomers[e][s]=t.getMonomer(e,s)}))}))}update(t){this._updateInt(t),this._onChanged.next()}updateLibs(t,e=!1){e&&(this._monomers={});for(const e of t)e.error||this._updateInt(e);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}}class w{constructor(){this._monomerLib=new y({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(t=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[e,s]=await Promise.all([u(),d()]),i=e.filter((t=>!s.exclude.includes(t))),n=await Promise.all(i.map((t=>this.readLibrary(c,t).catch((e=>{const s=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new y({},s)})))));this._monomerLib.updateLibs(n,t)}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;i.shell.warning(e);const s=t instanceof Error?t.stack:void 0;l._package.logger.error(e,void 0,s)}}))}async readLibrary(t,e){let s,n,o=[];const l=new r.FileSource(t);if(e.endsWith(".sdf"))1===r.Func.find({package:"Chem",name:"importSdf"}).length?(s=await l.readAsBytes(e),n=await i.functions.call("Chem:importSdf",{bytes:s}),o=(0,a.Xk)(n[0])):i.shell.warning("Chem package is not installed");else{const t=await l.readAsText(e);o=JSON.parse(t)}const h={},c=[];return o.forEach((t=>{c.includes(t.polymerType)||(h[t.polymerType]={},c.push(t.polymerType)),h[t.polymerType][t.symbol]=t})),new y(h)}static get instance(){return w._instance||(w._instance=new w),w._instance}}w._instance=null},525:(t,e,s)=>{"use strict";s.d(e,{K:()=>N});var i=s(4469),n=s(976),r=s(3870),o=s(8447),a=s(6098),l=s(8341),h=s(2568),c=s(7767),u=s(2140),m=s(3553),d=s(3379),p=s.n(d),g=s(7795),f=s.n(g),y=s(569),w=s.n(y),b=s(3565),v=s.n(b),C=s(9216),S=s.n(C),M=s(4589),A=s.n(M),T=s(9564),E={};E.styleTagTransform=A(),E.setAttributes=v(),E.insert=w().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=S(),p()(T.Z,E),T.Z&&T.Z.locals&&T.Z.locals;class x extends Error{constructor(t,e){super(t,e)}}async function N(t={}){return new Promise((async(e,s)=>{var o,a,h;t.clustersCol??(t.clustersCol=null),t.pepsea??(t.pepsea={}),(o=t.pepsea).method??(o.method=m.jB.pepsea.method),(a=t.pepsea).gapOpen??(a.gapOpen=m.jB.pepsea.gapOpen),(h=t.pepsea).gapExtend??(h.gapExtend=m.jB.pepsea.gapExtend);const c=t.col?.dataFrame??i.shell.t,u=t.col??c.columns.bySemType(n.SEMTYPE.MACROMOLECULE);if(null==u){const t="MSAError: dataset doesn't conain any Macromolecule column";i.shell.warning(t),s(new x(t))}const d=r.choiceInput("Method",t.pepsea.method,l.J);d.setTooltip("Alignment method");const p=r.floatInput("Terminal gap",t?.kalign?.terminalGap??null);p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=r.p(`Kalign version: ${m.WY}`,"kalign-version"),f=r.floatInput("Gap open",t.pepsea.gapOpen);f.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.floatInput("Gap extend",t.pepsea.gapExtend);y.setTooltip("Gap extension penalty to skip the alignment");const w=r.inputs([f,y,p]),b=r.button("Alignment parameters",(()=>{w.hidden=!w.hidden}),"Adjust alignment parameters such as penalties for opening and extending gaps");b.classList.add("msa-params-button"),w.hidden=!0,b.prepend(r.icons.settings((()=>null)));const v=[d.root.style],C=[p.root.style,g.style];let S;const M=r.columnInput("Sequence",c,u,(async()=>{S=await I(M.value,c,v,C,d,A,f,y,p)}),{filter:t=>t.semType===n.SEMTYPE.MACROMOLECULE});M.setTooltip("Sequences column to use for alignment");const A=r.columnInput("Clusters",c,t.clustersCol);if(A.nullable=!0,M.fireChanged(),t.col)return S=await I(t.col,c,v,C,d,A,f,y,p),void await L(M,c,S,e,s);r.dialog("MSA").add(M).add(A).add(d).add(w).add(b).add(g).onOK((async()=>{await L(M,c,S,e,s)})).show()}))}async function L(t,e,s,r,o){let a=null;const l=n.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(t.fireChanged(),t.value.semType!==n.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===s)throw new Error("Invalid column format");if(a=await s(),null==a)return o("PepSeA container has not started");e.columns.add(a),await i.data.detectSemanticTypes(e),r(a)}catch(t){const e=t instanceof Error?t.message:t.toString();i.shell.error(e),o(t)}finally{l.close()}}async function I(t,e,s,r,d,p,g,f,y){try{if(t.semType!==n.SEMTYPE.MACROMOLECULE)return;const i=e.columns.getUnusedName(`msa(${t.name})`);if((0,h.n)(t,t.name,[o.r2.FASTA,o.r2.SEPARATOR],["DNA","RNA","PT"],!1)){_(s,r,"kalign"),g.value=null,f.value=null,y.value=null;const e=new c.L(t),n=e.isFasta()?t:e.convert(o.r2.FASTA);return async()=>await(0,a.U)(n,!1,i,p.value)}if((0,h.n)(t,t.name,[o.r2.HELM],[],!1))return _(s,r,"pepsea"),g.value??(g.value=m.jB.pepsea.gapOpen),f.value??(f.value=m.jB.pepsea.gapExtend),async()=>await(0,l.f)(t,i,d.value,g.value,f.value,p.value);if((0,h.n)(t,t.name,[o.r2.SEPARATOR],["UN"],!1)){const e=new c.L(t).convert(o.r2.HELM);return _(s,r,"pepsea"),g.value??(g.value=m.jB.pepsea.gapOpen),f.value??(f.value=m.jB.pepsea.gapExtend),async()=>await(0,l.f)(e,i,d.value,g.value,f.value,p.value)}return g.value=null,f.value=null,y.value=null,void _(s,r,"kalign")}catch(t){const e=t instanceof Error?t.message:t.toString();i.shell.error(e),u._package.logger.error(e)}}function _(t,e,s){if("kalign"===s){for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}else{for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}}},6098:(t,e,s)=>{"use strict";s.d(e,{U:()=>k});var i=s(976),n=s(5226);const r=Symbol("Comlink.proxy"),o=Symbol("Comlink.endpoint"),a=Symbol("Comlink.releaseProxy"),l=Symbol("Comlink.thrown"),h=t=>"object"==typeof t&&null!==t||"function"==typeof t,c=new Map([["proxy",{canHandle:t=>h(t)&&t[r],serialize(t){const{port1:e,port2:s}=new MessageChannel;return u(t,e),[s,[s]]},deserialize:t=>(t.start(),d(t))}],["throw",{canHandle:t=>h(t)&&l in t,serialize({value:t}){let e;return e=t instanceof Error?{isError:!0,value:{message:t.message,name:t.name,stack:t.stack}}:{isError:!1,value:t},[e,[]]},deserialize(t){throw t.isError?Object.assign(new Error(t.value.message),t.value):t.value}}]]);function u(t,e=self){e.addEventListener("message",(function s(i){if(!i||!i.data)return;const{id:n,type:o,path:a}=Object.assign({path:[]},i.data),h=(i.data.argumentList||[]).map(v);let c;try{const e=a.slice(0,-1).reduce(((t,e)=>t[e]),t),s=a.reduce(((t,e)=>t[e]),t);switch(o){case"GET":c=s;break;case"SET":e[a.slice(-1)[0]]=v(i.data.value),c=!0;break;case"APPLY":c=s.apply(e,h);break;case"CONSTRUCT":c=function(t){return Object.assign(t,{[r]:!0})}(new s(...h));break;case"ENDPOINT":{const{port1:e,port2:s}=new MessageChannel;u(t,s),c=function(t,e){return w.set(t,e),t}(e,[e])}break;case"RELEASE":c=void 0;break;default:return}}catch(t){c={value:t,[l]:0}}Promise.resolve(c).catch((t=>({value:t,[l]:0}))).then((t=>{const[i,r]=b(t);e.postMessage(Object.assign(Object.assign({},i),{id:n}),r),"RELEASE"===o&&(e.removeEventListener("message",s),m(e))}))})),e.start&&e.start()}function m(t){(function(t){return"MessagePort"===t.constructor.name})(t)&&t.close()}function d(t,e){return g(t,[],e)}function p(t){if(t)throw new Error("Proxy has been released and is not useable")}function g(t,e=[],s=function(){}){let i=!1;const n=new Proxy(s,{get(s,r){if(p(i),r===a)return()=>C(t,{type:"RELEASE",path:e.map((t=>t.toString()))}).then((()=>{m(t),i=!0}));if("then"===r){if(0===e.length)return{then:()=>n};const s=C(t,{type:"GET",path:e.map((t=>t.toString()))}).then(v);return s.then.bind(s)}return g(t,[...e,r])},set(s,n,r){p(i);const[o,a]=b(r);return C(t,{type:"SET",path:[...e,n].map((t=>t.toString())),value:o},a).then(v)},apply(s,n,r){p(i);const a=e[e.length-1];if(a===o)return C(t,{type:"ENDPOINT"}).then(v);if("bind"===a)return g(t,e.slice(0,-1));const[l,h]=y(r);return C(t,{type:"APPLY",path:e.map((t=>t.toString())),argumentList:l},h).then(v)},construct(s,n){p(i);const[r,o]=y(n);return C(t,{type:"CONSTRUCT",path:e.map((t=>t.toString())),argumentList:r},o).then(v)}});return n}function f(t){return Array.prototype.concat.apply([],t)}function y(t){const e=t.map(b);return[e.map((t=>t[0])),f(e.map((t=>t[1])))]}const w=new WeakMap;function b(t){for(const[e,s]of c)if(s.canHandle(t)){const[i,n]=s.serialize(t);return[{type:"HANDLER",name:e,value:i},n]}return[{type:"RAW",value:t},w.get(t)||[]]}function v(t){switch(t.type){case"HANDLER":return c.get(t.name).deserialize(t.value);case"RAW":return t.value}}function C(t,e,s){return new Promise((i=>{const n=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");t.addEventListener("message",(function e(s){!s.data||!s.data.id||s.data.id!==n||(t.removeEventListener("message",e),i(s.data))})),t.start&&t.start(),t.postMessage(Object.assign({id:n},e),s)}))}const S="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),u=(s.data.argumentList||[]).map(m);let l;try{const c=n.slice(0,-1).reduce((d,h)=>d[h],e),f=n.reduce((d,h)=>d[h],e);switch(a){case"GET":l=f;break;case"SET":c[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(c,u);break;case"CONSTRUCT":{const d=new f(...u);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:h}=new MessageChannel;w(e,h),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(c){l={value:c,[y]:0}}Promise.resolve(l).catch(c=>({value:c,[y]:0})).then(c=>{const[f,d]=S(c);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),F(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function F(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function p(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(p(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(u=>u.toString())}).then(()=>{F(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const u=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return u.then.bind(u)}return b(e,[...r,n])},set(a,n,u){p(s);const[l,c]=S(u);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},c).then(m)},apply(a,n,u){p(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[c,f]=M(u);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:c},f).then(m)},construct(a,n){p(s);const[u,l]=M(n);return g(e,{type:"CONSTRUCT",path:r.map(c=>c.toString()),argumentList:u},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function M(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),x="eager",k="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const u=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${u}`),t.fs.symlink(u,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var u;let n=i;return((u=a==null?void 0:a.features)==null?void 0:u.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==k&&(s.loading=x,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};if(t.config.printInterleaved&&(o=s.stdout),s.reinit===!0){const a=t.base.module.FS.cwd();Object.assign(s,s.config),s.ready=!1,await this.init(),s.isBaseModule&&this.mount(),this.cd(a)}return o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=x),e.loading===k){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>e.stdout+=`${i}
`,printErr:t.config.printInterleaved?i=>e.stdout+=`${i}
`:i=>e.stderr+=`${i}
`});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",M=typeof window<"u"&&window.Blob&&new Blob([atob(S)],{type:"text/javascript;charset=utf-8"});function A(){const t=M&&(window.URL||window.webkitURL).createObjectURL(M);try{return t?new Worker(t):new Worker("data:application/javascript;base64,"+S)}finally{t&&(window.URL||window.webkitURL).revokeObjectURL(t)}}const T={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,callback:null,debug:!1,env:"prd"};class E{constructor(t,e={}){if(null==t)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(t)||(t=[t]),e=Object.assign({},T,e),t=t.map(this._parseTool),"stg"===e.env&&(e.urlCDN=e.urlCDNStg),this.tools=t,this.config=e,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const t=new A;this.callback&&(t.onmessage=t=>{"biowasm"===t.data.type&&this.callback(t.data.value)});const e=d(t);return e.tools=this.tools,e.config=this.config,await e.init(),e}_parseTool(t){if("string"!=typeof t)return t;const e=t.split("/");if(2!=e.length&&3!=e.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:e[0],program:3==e.length?e[1]:e[0],version:e[e.length-1]}}}var x=s(7997);class N{static getAvailableScales(){return Object.entries(this.scales).map((([t,e])=>t))}static getScale(t){return(0,x.hu)(!(void 0===this.scales[t]),`Scale '${t}' was not found.`),this.scales[t]}}N.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class L{constructor(t="categorial"){this.aa2num=N.getScale(t),this.num2aa={},Object.entries(this.aa2num).forEach((([t,e])=>this.num2aa[e]=t))}static _truncateSequence(t){let e=0,s=t.length;const i=["NH2","COOH"];if(t.startsWith(i[0])){const s=i[0].length;(0,x.hu)("-"==t[s],`Wrong sequence format: ${i[0]} without following '-' in '${t}'.`),e=s}if(t.endsWith(i[1])){const e=i[1].length+1;(0,x.hu)("-"==t[s-e],`Wrong sequence format: ${i[1]} without '-' precending in '${t}'.`),s-=e}return t.substring(e,s)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return L._dropDefises(L._truncateSequence(t))}encode(t){const e=t.length,s=new Array(e).fill(0);for(let i=0;i<e;++i){const e=t[i];(0,x.hu)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),s[i]=this.encodeLettter(e)}return s}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let s=0;s<t.length;++s){const i=t[s];(0,x.hu)(i in this.num2aa,`Unknown code '${i}' found in vector '${t}'`),e+=this.num2aa[i]}return e}}var I=s(3553);const _="input.fa",R="result.fasta";function O(t){return t.reduce(((t,e,s)=>t+`>sample${s+1}\n${e}\n`),"")}async function k(t,e=!1,s="",r=null,o,a,l){let h=t.toList();e&&(h=h.map((t=>L.clean(t).replace(/\-/g,""))));const c=t.length;r??(r=i.Column.string("Clusters",c).init("0")),r.type!=i.COLUMN_TYPE.STRING&&(r=r.convertTo(i.TYPE.STRING)),r.compact();const u=r.categories,m=r.getRawData(),d=new Array(u.length),p=new Array(u.length);for(let t=0;t<c;++t){const e=m[t];(d[e]??(d[e]=[])).push(h[t]),(p[e]??(p[e]=[])).push(t)}const g=await new E(["base/1.0.0",{tool:"kalign",version:I.WY,reinit:!0}]),f=i.Column.string(s,c);for(let t=0;t<u.length;++t){const e=O(d[t]);await g.fs.writeFile(_,e);const s=`${void 0!==o?` --gpo ${o}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,i=await g.exec(`kalign ${_} -f fasta -o ${R}${s}`);console.warn(i);const r=await g.cat(R);if(!r)throw new Error("kalign output no result");const h=new n.i(r).sequencesArray,c=p[t];for(let t=0;t<h.length;++t)f.set(c[t],h[t])}const y=t.getTag(i.TAGS.UNITS),w=t.getTag("alphabet");return f.setTag(i.TAGS.UNITS,y),f.setTag("aligned","SEQ.MSA"),f.setTag("alphabet",w),f.semType=i.SEMTYPE.MACROMOLECULE,f}},8341:(t,e,s)=>{"use strict";s.d(e,{J:()=>a,f:()=>h});var i=s(4469),n=s(976),r=s(8447),o=s(3553);const a=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function h(t,e,s="ginsi",a=1.53,h=0,u=null){const m=await i.dapi.docker.dockerContainers.filter("bio").first();if("started"!==m.status&&"checking"!==m.status)return i.log.warning("PepSeA container has not started yet"),null;const d=t.length;u??(u=n.Column.int("Clusters",d).init(0)),u.type!=n.COLUMN_TYPE.STRING&&(u=u.convertTo(n.TYPE.STRING));const p=u.categories,g=new Array(p.length);for(let e=0;e<d;++e){const s=u.get(e);if(""===s)continue;const i=p.indexOf(s),n=t.get(e);n&&(g[i]??(g[i]=[])).push({ID:e.toString(),HELM:n})}const f=new Array(d);for(const t of g){const e=(await c(m.id,t,s,a,h)).Alignment;for(const t of e)f[parseInt(t.ID)]=Object.entries(t).filter((t=>!l.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(o.rs.SEPARATOR)}const y=n.Column.fromStrings(e,f);return y.setTag(n.TAGS.UNITS,r.r2.SEPARATOR),y.setTag("separator",o.rs.SEPARATOR),y.setTag("aligned","SEQ.MSA"),y.setTag("alphabet","UN"),y.setTag(".alphabetIsMultichar","true"),y.semType=n.SEMTYPE.MACROMOLECULE,y}async function c(t,e,s,n,r){const o={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},a=`/align?method=${s}&gap_open=${n}&gap_extend=${r}`,l=await i.dapi.docker.dockerContainers.request(t,a,o);return JSON.parse(l??"{}")}},9943:(t,e,s)=>{"use strict";s.d(e,{C2:()=>u});var i=s(976),n=s(3870),r=s(4469),o=s(6414),a=s.n(o),l=s(8447),h=s(499);const c=60;function u(){const t=r.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),s=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),o=s?[s.name]:[],u=n.multiChoiceInput("Seq id columns",o,e.map((t=>t.name))),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&h.Cn.getOrCreate(e).isFasta()})).toArray(),p=d.length>0?d[0].name:[],g=n.choiceInput("Seq column",p,d.map((t=>t.name))),f=n.intInput("FASTA line width",c);n.dialog({title:"Save as FASTA"}).add(n.inputs([u,g,f])).onOK((()=>{const e=u.value?u.value.map((e=>t.columns.byName(e).column)):[],s=g.value?t.columns.byName(g.value).column:null,i=f.value??c;s||r.shell.warning("Seq column is mandatory to save as FASTA.");const n=function(t,e,s=c,i="\n"){const n=l.kB,r=[];for(let o=0;o<e.length;o++){const a=t.map((t=>t.get(o).toString())).join("|"),l=m(e.get(o),n,s);r.push(`>${a}${i}`);for(const t of l)r.push(`${t}${i}`)}return"".concat(...r)}(e,s,i),o=document.createElement("a");o.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(n)}`),o.setAttribute("download",`${t.dataFrame.name}.fasta`),o.click()})).show()}function m(t,e,s=c){const i=e(t);let n=0;const r=i.length,o=[];for(;n<r;){const t=a()(i).slice(n,n+s).toArray(),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");o.push(e),n+=t.length}return o}},9416:(t,e,s)=>{"use strict";s.d(e,{n:()=>h});var i=s(4469),n=s(976),r=s(1061),o=s(2568),a=s(8457),l=s(3553);async function h(t,e){if(await(0,r.gw)(10),!(0,o.n)(e,"Sequence space"))return t;const s=(0,a.O)(e);s.name="splitToMonomers";const h=e.dataFrame;for(const t of s.columns)t.semType=l.Of.MONOMER,t.setTag("alphabet",e.getTag("alphabet"));const c=/(\d+)(?: \((\d+)\))?/,u=t=>{c.lastIndex=0;const e=t.match(c);return e?`${e[1]} (${parseInt(e[2]??0)+1})`:t};for(let t=0;t<s.columns.length;t++){const i=s.columns.byIndex(t);i.semType=l.Of.MONOMER,i.setTag("alphabet",e.getTag("alphabet"));const n=100;let r=0;for(;h.columns.byName(i.name)&&r<n;)i.name=u(i.name),r++;h.columns.add(i)}await i.data.detectSemanticTypes(h);for(let t=0;t<s.columns.length;t++)s.columns.byIndex(t).setTag(n.TAGS.CELL_RENDERER,"Monomer");return h}},4293:(t,e,s)=>{"use strict";s.d(e,{B:()=>r,Y:()=>o});var i=s(4469),n=s(976);function r(){const t=i.shell.t.columns.bySemTypeAll(n.SEMTYPE.MACROMOLECULE);if(null!==t)return t;i.shell.error("Current table does not contain macromolecules")}function o(t,e){t.innerHTML="",t.append(e)}},833:(t,e,s)=>{"use strict";s.d(e,{bo:()=>p,OZ:()=>v});var i=s(4469),n=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(701),h=s(499),c=s(8447),u=s(9298);function m(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?m(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var d,p,g=s(2140);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const s=this.getBoundingClientRect();return new r.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class f{constructor(t=0,e){this.count=t,this.bounds=e}}class y{get label(){return this._label?this._label:this.name}constructor(t,e,s,i){this.pos=t,this.name=e,this._freqs=s??{},i?.rowCount&&(this.rowCount=i.rowCount),i?.sumForHeightCalc&&(this.sumForHeightCalc=i.sumForHeightCalc),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new f),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,i])=>i.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,i,n,o,a,l,h){const c=i==u.ES.Entropy?s*(n-this.sumForHeightCalc)/n:s;let m=h*l+(s-c-1);const d=Object.entries(this._freqs).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const s of d){const i=s[1],n=c*i.count/this.rowCount;i.bounds=new r.Rect((t-e)*l*o,m,a*l,n),m+=n}}render(t,e,s,i,n){for(const[r,o]of Object.entries(this._freqs))if("-"!==r){const a=(0,c.GU)(r,5),l=o.bounds,h=l.left;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(h,l.top,l.width,l.height),t.fillStyle=n.get(r)??n.get("other"),t.textAlign="left",t.font=e;const u=t.measureText(a);t.setTransform(l.width/u.width,0,0,l.height/i,h,l.top),t.fillText(a,0,-s)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(p||(p={}));const w=u.vS;var b;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(b||(b={}));class v extends r.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewSubs=[],this._onSizeChanged=new l.Subject,this._onFreqsCalculated=new l.Subject,this._onLayoutCalculated=new l.Subject,this.renderLevelRequested=b.Freqs,this.viewerId=v.viewerCount,v.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(p.sequenceColumnName,w.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(p.startPositionName,w.startPositionName,{category:d.DATA}),this.endPositionName=this.string(p.endPositionName,w.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(p.skipEmptySequences,w.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(p.skipEmptyPositions,w.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(p.shrinkEmptyTail,w.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(p.backgroundColor,w.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(p.positionHeight,w.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(p.positionWidth,w.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(p.verticalAlignment,w.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(p.horizontalAlignment,w.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(p.fixWidth,w.fixWidth,{category:d.LAYOUT,userEditable:!1}),this.fitArea=this.bool(p.fitArea,w.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(p.minHeight,w.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(p.maxHeight,w.maxHeight,{category:d.LAYOUT}),this.showPositionLabels=this.bool(p.showPositionLabels,w.showPositionLabels,{category:d.LAYOUT}),this.positionMarginState=this.string(p.positionMarginState,w.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(p.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(p.filterSource,w.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=n.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=n.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%"}setData(){this.viewed&&(this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.viewed||(this.buildView(),this.viewed=!0)}async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),super.detach(),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=n.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=n.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=n.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,n.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),await this.render(b.Freqs,"buildView"),g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(b.Layout,"rootOnSizeChanged").then((()=>{}))}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqCol.getTag(r.TAGS.UNITS),this.seqCol.getTag("separator"),this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.cp=(0,c.dQ)(this.seqCol),this.updatePositions(),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,e=a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(u.DX.positionNames),i=this.seqCol.getTag(u.DX.positionLabels);this.positionNames=s?s.split(u.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=i?i.split(u.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1,this.render(b.Freqs,"updatePositions").then((()=>{}))}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&0!==this.root.clientHeight&&0!==this.root.clientWidth&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.fitArea?this.calcLayoutFitArea(t):this.calcLayoutNoFitArea(t))}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=u.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,this.Length-1,0,this.Length-1),this.canvas.width=e*t,this.canvas.height=s*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=Math.min(this.root.clientWidth,e);this.canvas.style.width=`${i}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${i}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${i+6}px`),this.host.style.width=`${this.host}px`;const n=e>i;if(this.setSliderVisibility(n),n){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=i*t,this.canvas.height=s*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,n=this.root.clientHeight/s,r=Math.max(1,Math.min(i,n));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*s,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const h=o>l;if(this.setSliderVisibility(h),h){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=l*t,this.canvas.height=a*t}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case p.sequenceColumnName:this.updateSeqCol();break;case p.sequenceColumnName:case p.startPositionName:case p.endPositionName:case p.filterSource:case p.shrinkEmptyTail:case p.skipEmptyPositions:case p.positionHeight:this.updatePositions();break;case p.minHeight:case p.maxHeight:case p.positionWidth:case p.showPositionLabels:case p.fixWidth:case p.fitArea:case p.horizontalAlignment:case p.verticalAlignment:case p.positionMargin:case p.positionMarginState:this.render(b.Layout,`onPropertyChanged(${t.name})`).then((()=>{}));break;case p.backgroundColor:this.render(b.Render,`onPropertyChanged(${t.name})`).then((()=>{}))}}onTableAttached(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){this.viewed&&(this.destroyView(),this.viewed=!1)}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const s=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),n=this.positions[i];if(void 0===n)return[i,null,null];const r=n.getMonomerAt(s,t.y);return void 0===r?[i,null,null]:[i,r,n.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>!t.hasMonomer("-")||t.getFreq("-").count!==t.rowCount)).toArray())}render(t,e){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevel=${t}, reason='${e}' )`);const s=()=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new y(this.startPosition+e,t,{},{label:s})}const s=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,i=this.dataFrame.rowCount,n=this.unitsHandler.splitted;for(let e=0;e<i;++e)if(s.get(e)){const s=n[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||"-";this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()},n=(t,e)=>{g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `),this.calcLayout(t);const s=this.canvas.height-e*t,n=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==n&&i.shell.error("WebLogo: alphabet is undefined.");const r=Math.log2(n);for(let i=Math.floor(this.slider.min);i<=Math.floor(this.slider.max);++i)this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,r,this._positionWidthWithMargin,this._positionWidth,t,e);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()},o=t=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const i=window.devicePixelRatio,o=this.showPositionLabels?12:0;t>=b.Freqs&&s(),t>=b.Layout&&n(window.devicePixelRatio,o),this.Length,e.resetTransform(),e.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const a=10*i;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),h=l<this._positionWidth*i-2?1:(this._positionWidth*i-2)/l;o>0&&function(t,e,s,i,n,r,o,a){for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=r[l];t.resetTransform(),t.setTransform(s,0,0,1,(l-o)*i*e+n*e/2,0),t.fillText(a.label,0,1)}}(e,i,h,this._positionWidthWithMargin,this._positionWidth,this.positions,this.slider.min,this.slider.max);for(let t=Math.floor(this.slider.min);t<=Math.floor(this.slider.max);t++)this.positions[t].render(e,"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.cp);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)};return this.renderLevelRequested=Math.max(this.renderLevelRequested,t),new Promise(((t,e)=>{window.setTimeout((()=>{try{if(this.renderLevelRequested>b.None)try{o(this.renderLevelRequested)}finally{this.renderLevelRequested=b.None}}catch(t){e(t)}}),0)}))}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(t)} ), start`),this.render(b.Layout,"sliderOnValuesChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){g._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()");try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(b.Freqs,"dataFrameFilterOnChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){g._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()");try{this.filterSource===u.Ct.Selected&&this.render(b.Freqs,"dataFrameSelectionOnChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,i=this.canvas.getCursorPosition(s,e),[r,o]=this.getMonomer(i,e);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],e=function(t,e,s,i,n){let r=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const t=e.splitted[o],s=n.pos;(s<t.length?t[s]:null)===i&&r++}return r}(this.dataFrame,this.unitsHandler,this.filter,o,t),i=n.div([n.div(`${o}`),n.div(`${e} rows`)]);n.tooltip.show(i,s.x+16,s.y+16)}else n.tooltip.hide()}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[i,n]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&n){const t=this.positions[i],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,i,n,r){const o=e.splitted[i],a=r.pos<o.length?o[r.pos]:null;return a===n||""===a&&"-"===n}(this.dataFrame,this.unitsHandler,this.filter,e,n,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n"+e)}}}v.residuesSet="nucleotides",v.viewerCount=0},4413:(t,e,s)=>{"use strict";s.d(e,{ST:()=>p});var i=s(3870),n=s(976),r=s(4469),o=s(6414),a=s.n(o),l=s(7983),h=s(701),c=s(4293),u=s(8447),m=s(1061);const d=rxjs.operators;class p extends n.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=i.loader(),this.notation=void 0,this.root=i.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(n.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(n.TAGS.UNITS)),this.bioFilter=this.notation===u.r2.FASTA?new f:this.notation===u.r2.SEPARATOR?new y(this.column.getTag("separator")):new w,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class g{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class f extends g{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class y extends f{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t,this.colSeparator)}}class w extends g{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await r.functions.call("HELM:helmWebEditor"),await i.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:s}=this.helmEditor.createWebEditor(this.helmSubstructure);i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),i.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=e/2;if(t)(0,c.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,s);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,c.Y)(this._filterPanel,t)}}async substrucrureSearch(t){i.setUpdateIndicator(this._filterPanel,!0),await(0,m.gw)(10);const e=await(0,l.QF)(this.substructure,t);return i.setUpdateIndicator(this._filterPanel,!1),e}}},9378:function(t,e,s){"use strict";var i=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var n=i(s(4517));function r(t,e){var s=function(s){return n.empty(t).map((function(){return n.filled(e,s)}))},i=[];return i.push(s(-1)),i.push(s(1/0)),i.push(s(0)),i}function o(t,e,s,i,n){e=Math.floor(e);var r=t[0][e],o=t[1][e];if(t[2][e],s>=o[0])return 0;for(var l=0;l<r.length;l++)if(i===r[l])return 0;return a(t,e,s,i,n)}function a(t,e,s,i,n){var r=t[0][e],o=t[1][e],a=t[2][e];if(s>=o[0])return 0;o[0]=s,r[0]=i,a[0]=n;for(var l=0,h=0;;){var c=2*l+1,u=c+1,m=t[0][0].length;if(c>=m)break;if(u>=m){if(!(o[c]>s))break;h=c}else if(o[c]>=o[u]){if(!(s<o[c]))break;h=c}else{if(!(s<o[u]))break;h=u}o[l]=o[h],r[l]=r[h],a[l]=a[h],l=h}return o[l]=s,r[l]=i,a[l]=n,1}function l(t,e,s,i){for(;2*i+1<s;){var n=2*i+1,r=n+1,o=i;if(t[o]<t[n]&&(o=n),r<s&&t[o]<t[r]&&(o=r),o===i)break;var a=t[i];t[i]=t[o],t[o]=a;var l=e[i];e[i]=e[o],e[o]=l,i=o}}e.makeHeap=r,e.rejectionSample=function(t,e,s){for(var i=n.zeros(t),r=0;r<t;r++){for(var o=!0,a=0;o;){a=n.tauRandInt(e,s);for(var l=!1,h=0;h<r;h++)if(a===i[h]){l=!0;break}l||(o=!1)}i[r]=a}return i},e.heapPush=o,e.uncheckedHeapPush=a,e.buildCandidates=function(t,e,s,i,a){for(var l=r(e,i),h=0;h<e;h++)for(var c=0;c<s;c++)if(!(t[0][h][c]<0)){var u=t[0][h][c],m=t[2][h][c],d=n.tauRand(a);o(l,h,d,u,m),o(l,u,d,h,m),t[2][h][c]=0}return l},e.deheapSort=function(t){for(var e=t[0],s=t[1],i=0;i<e.length;i++)for(var n=e[i],r=s[i],o=0;o<n.length-1;o++){var a=n.length-o-1,h=r.length-o-1,c=n[0];n[0]=n[a],n[a]=c;var u=r[0];r[0]=r[h],r[h]=u,l(r,n,h,0)}return{indices:e,weights:s}},e.smallestFlagged=function(t,e){for(var s=t[0][e],i=t[1][e],n=t[2][e],r=1/0,o=-1,a=0;a>s.length;a++)1===n[a]&&i[a]<r&&(r=i[a],o=a);return o>=0?(n[o]=0,Math.floor(s[o])):-1}},4221:(t,e,s)=>{"use strict";var i=s(4364);e.u=i.UMAP},5686:function(t,e,s){"use strict";var i,n=this&&this.__read||function(t,e){var s="function"==typeof Symbol&&t[Symbol.iterator];if(!s)return t;var i,n,r=s.call(t),o=[];try{for(;(void 0===e||e-- >0)&&!(i=r.next()).done;)o.push(i.value)}catch(t){n={error:t}}finally{try{i&&!i.done&&(s=r.return)&&s.call(r)}finally{if(n)throw n.error}}return o},r=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}},o=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var a=o(s(4517)),l=function(){function t(t,e,s,i){if(this.entries=new Map,this.nRows=0,this.nCols=0,t.length!==e.length||t.length!==s.length)throw new Error("rows, cols and values arrays must all have the same length");this.nRows=i[0],this.nCols=i[1];for(var n=0;n<s.length;n++){var r=t[n],o=e[n];this.checkDims(r,o);var a=this.makeKey(r,o);this.entries.set(a,{value:s[n],row:r,col:o})}}return t.prototype.makeKey=function(t,e){return t+":"+e},t.prototype.checkDims=function(t,e){if(!(t<this.nRows&&e<this.nCols))throw new Error("row and/or col specified outside of matrix dimensions")},t.prototype.set=function(t,e,s){this.checkDims(t,e);var i=this.makeKey(t,e);this.entries.has(i)?this.entries.get(i).value=s:this.entries.set(i,{value:s,row:t,col:e})},t.prototype.get=function(t,e,s){void 0===s&&(s=0),this.checkDims(t,e);var i=this.makeKey(t,e);return this.entries.has(i)?this.entries.get(i).value:s},t.prototype.getAll=function(t){void 0===t&&(t=!0);var e=[];return this.entries.forEach((function(t){e.push(t)})),t&&e.sort((function(t,e){return t.row===e.row?t.col-e.col:t.row-e.row})),e},t.prototype.getDims=function(){return[this.nRows,this.nCols]},t.prototype.getRows=function(){return Array.from(this.entries,(function(t){var e=n(t,2);return e[0],e[1].row}))},t.prototype.getCols=function(){return Array.from(this.entries,(function(t){var e=n(t,2);return e[0],e[1].col}))},t.prototype.getValues=function(){return Array.from(this.entries,(function(t){var e=n(t,2);return e[0],e[1].value}))},t.prototype.forEach=function(t){this.entries.forEach((function(e){return t(e.value,e.row,e.col)}))},t.prototype.map=function(e){var s=[];this.entries.forEach((function(t){s.push(e(t.value,t.row,t.col))}));var i=[this.nRows,this.nCols];return new t(this.getRows(),this.getCols(),s,i)},t.prototype.toArray=function(){var t=this,e=a.empty(this.nRows).map((function(){return a.zeros(t.nCols)}));return this.entries.forEach((function(t){e[t.row][t.col]=t.value})),e},t}();e.SparseMatrix=l,e.transpose=function(t){var e=[],s=[],i=[];t.forEach((function(t,n,r){e.push(n),s.push(r),i.push(t)}));var n=[t.nCols,t.nRows];return new l(s,e,i,n)},e.identity=function(t){for(var e=n(t,1)[0],s=new l([],[],[],t),i=0;i<e;i++)s.set(i,i,1);return s},e.pairwiseMultiply=function(t,e){return c(t,e,(function(t,e){return t*e}))},e.add=function(t,e){return c(t,e,(function(t,e){return t+e}))},e.subtract=function(t,e){return c(t,e,(function(t,e){return t-e}))},e.maximum=function(t,e){return c(t,e,(function(t,e){return t>e?t:e}))},e.multiplyScalar=function(t,e){return t.map((function(t){return t*e}))},e.eliminateZeros=function(t){for(var e=new Set,s=t.getValues(),i=t.getRows(),n=t.getCols(),r=0;r<s.length;r++)0===s[r]&&e.add(r);var o=function(t,s){return!e.has(s)},a=s.filter(o),h=i.filter(o),c=n.filter(o);return new l(h,c,a,t.getDims())},e.normalize=function(t,e){var s,i;void 0===e&&(e="l2");var n=h[e],o=new Map;t.forEach((function(t,e,s){var i=o.get(e)||[];i.push(s),o.set(e,i)}));var a=new l([],[],[],t.getDims()),c=function(e){for(var s=o.get(e).sort(),i=s.map((function(s){return t.get(e,s)})),r=n(i),l=0;l<r.length;l++)a.set(e,s[l],r[l])};try{for(var u=r(o.keys()),m=u.next();!m.done;m=u.next())c(m.value)}catch(t){s={error:t}}finally{try{m&&!m.done&&(i=u.return)&&i.call(u)}finally{if(s)throw s.error}}return a};var h=((i={}).max=function(t){for(var e=-1/0,s=0;s<t.length;s++)e=t[s]>e?t[s]:e;return t.map((function(t){return t/e}))},i.l1=function(t){for(var e=0,s=0;s<t.length;s++)e+=t[s];return t.map((function(t){return t/e}))},i.l2=function(t){for(var e=0,s=0;s<t.length;s++)e+=Math.pow(t[s],2);return t.map((function(t){return Math.sqrt(Math.pow(t,2)/e)}))},i);function c(t,e,s){for(var i=new Set,n=[],r=[],o=[],a=function(i,a){n.push(i),r.push(a);var l=s(t.get(i,a),e.get(i,a));o.push(l)},h=t.getValues(),c=t.getRows(),u=t.getCols(),m=0;m<h.length;m++){var d=(y=c[m])+":"+(w=u[m]);i.add(d),a(y,w)}var p=e.getValues(),g=e.getRows(),f=e.getCols();for(m=0;m<p.length;m++){var y,w;d=(y=g[m])+":"+(w=f[m]),i.has(d)||a(y,w)}var b=[t.nRows,t.nCols];return new l(n,r,o,b)}e.getCSR=function(t){var e=[];t.forEach((function(t,s,i){e.push({value:t,row:s,col:i})})),e.sort((function(t,e){return t.row===e.row?t.col-e.col:t.row-e.row}));for(var s=[],i=[],n=[],r=-1,o=0;o<e.length;o++){var a=e[o],l=a.row,h=a.col,c=a.value;l!==r&&(r=l,n.push(o)),s.push(h),i.push(c)}return{indices:s,values:i,indptr:n}}},760:function(t,e,s){"use strict";var i=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}},n=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var r=n(s(9378)),o=n(s(5686)),a=n(s(2320)),l=n(s(4517));e.makeNNDescent=function(t,e){return function(s,i,n,o,a,h,c,u){void 0===o&&(o=10),void 0===a&&(a=50),void 0===h&&(h=.001),void 0===c&&(c=.5),void 0===u&&(u=!0);for(var m=s.length,d=r.makeHeap(s.length,n),p=0;p<s.length;p++)for(var g=r.rejectionSample(n,s.length,e),f=0;f<g.length;f++){var y=t(s[p],s[g[f]]);r.heapPush(d,p,y,g[f],1),r.heapPush(d,g[f],y,p,1)}if(u)for(var w=0;w<i.length;w++)for(p=0;p<i[w].length&&!(i[w][p]<0);p++)for(f=p+1;f<i[w].length&&!(i[w][f]<0);f++)y=t(s[i[w][p]],s[i[w][f]]),r.heapPush(d,i[w][p],y,i[w][f],1),r.heapPush(d,i[w][f],y,i[w][p],1);for(w=0;w<o;w++){var b=r.buildCandidates(d,m,n,a,e),v=0;for(p=0;p<m;p++)for(f=0;f<a;f++){var C=Math.floor(b[0][p][f]);if(!(C<0||l.tauRand(e)<c))for(var S=0;S<a;S++){var M=Math.floor(b[0][p][S]),A=b[2][p][f],T=b[2][p][S];M<0||!A&&!T||(y=t(s[C],s[M]),v+=r.heapPush(d,C,y,M,1),v+=r.heapPush(d,M,y,C,1))}}if(v<=h*n*s.length)break}return r.deheapSort(d)}},e.makeInitializations=function(t){return{initFromRandom:function(e,s,i,n,o){for(var a=0;a<i.length;a++)for(var h=l.rejectionSample(e,s.length,o),c=0;c<h.length;c++)if(!(h[c]<0)){var u=t(s[h[c]],i[a]);r.heapPush(n,a,u,h[c],1)}},initFromTree:function(e,s,i,n,o){for(var l=0;l<i.length;l++)for(var h=a.searchFlatTree(i[l],e,o),c=0;c<h.length;c++){if(h[c]<0)return;var u=t(s[h[c]],i[l]);r.heapPush(n,l,u,h[c],1)}}}},e.makeInitializedNNSearch=function(t){return function(e,s,n,a){for(var l,h,c=o.getCSR(s),u=c.indices,m=c.indptr,d=0;d<a.length;d++)for(var p=new Set(n[0][d]);;){var g=r.smallestFlagged(n,d);if(-1===g)break;var f=u.slice(m[g],m[g+1]);try{for(var y=i(f),w=y.next();!w.done;w=y.next()){var b=w.value;if(b!==g&&-1!==b&&!p.has(b)){var v=t(e[b],a[d]);r.uncheckedHeapPush(n,d,v,b,1),p.add(b)}}}catch(t){l={error:t}}finally{try{w&&!w.done&&(h=y.return)&&h.call(y)}finally{if(l)throw l.error}}}return n}},e.initializeSearch=function(t,e,s,n,o,a,l){var h,c,u=r.makeHeap(s.length,n);if(o(n,e,s,u,l),t)try{for(var m=i(t),d=m.next();!d.done;d=m.next())a(d.value,e,s,u,l)}catch(t){h={error:t}}finally{try{d&&!d.done&&(c=m.return)&&c.call(m)}finally{if(h)throw h.error}}return u}},2320:function(t,e,s){"use strict";var i=this&&this.__read||function(t,e){var s="function"==typeof Symbol&&t[Symbol.iterator];if(!s)return t;var i,n,r=s.call(t),o=[];try{for(;(void 0===e||e-- >0)&&!(i=r.next()).done;)o.push(i.value)}catch(t){n={error:t}}finally{try{i&&!i.done&&(s=r.return)&&s.call(r)}finally{if(n)throw n.error}}return o},n=this&&this.__spread||function(){for(var t=[],e=0;e<arguments.length;e++)t=t.concat(i(arguments[e]));return t},r=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}},o=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var a=o(s(4517)),l=function(t,e,s,i){this.hyperplanes=t,this.offsets=e,this.children=s,this.indices=i};function h(t,e,s,i,n){if(void 0===s&&(s=30),e.length>s){var r=function(t,e,s){var i=t[0].length,n=a.tauRandInt(e.length,s),r=a.tauRandInt(e.length,s);r=(r+=n===r?1:0)%e.length;for(var o=e[n],l=e[r],h=0,c=a.zeros(i),u=0;u<c.length;u++)c[u]=t[o][u]-t[l][u],h-=c[u]*(t[o][u]+t[l][u])/2;var m=0,d=0,p=a.zeros(e.length);for(u=0;u<e.length;u++){for(var g=h,f=0;f<i;f++)g+=c[f]*t[e[u]][f];0===g?(p[u]=a.tauRandInt(2,s),0===p[u]?m+=1:d+=1):g>0?(p[u]=0,m+=1):(p[u]=1,d+=1)}var y=a.zeros(m),w=a.zeros(d);for(m=0,d=0,u=0;u<p.length;u++)0===p[u]?(y[m]=e[u],m+=1):(w[d]=e[u],d+=1);return{indicesLeft:y,indicesRight:w,hyperplane:c,offset:h}}(t,e,n),o=r.indicesLeft,l=r.indicesRight,c=r.hyperplane,u=r.offset;return{leftChild:h(t,o,s,i+1,n),rightChild:h(t,l,s,i+1,n),isLeaf:!1,hyperplane:c,offset:u}}return{indices:e,isLeaf:!0}}function c(t,e,s,i,r,o,a){var l;if(t.isLeaf)return i[o][0]=-a,(l=r[a]).splice.apply(l,n([0,t.indices.length],t.indices)),{nodeNum:o,leafNum:a+=1};e[o]=t.hyperplane,s[o]=t.offset,i[o][0]=o+1;var h=o,u=c(t.leftChild,e,s,i,r,o+1,a);return o=u.nodeNum,a=u.leafNum,i[h][1]=o+1,{nodeNum:(u=c(t.rightChild,e,s,i,r,o+1,a)).nodeNum,leafNum:u.leafNum}}function u(t){return t.isLeaf?1:1+u(t.leftChild)+u(t.rightChild)}function m(t){return t.isLeaf?1:m(t.leftChild)+m(t.rightChild)}function d(t,e,s,i){for(var n=e,r=0;r<s.length;r++)n+=t[r]*s[r];return 0===n?a.tauRandInt(2,i):n>0?0:1}e.FlatTree=l,e.makeForest=function(t,e,s,i){var n=Math.max(10,e);return a.range(s).map((function(e,s){return function(t,e,s,i){return void 0===e&&(e=30),h(t,a.range(t.length),e,s,i)}(t,n,s,i)})).map((function(t){return function(t,e){var s=u(t),i=m(t),n=a.range(s).map((function(){return a.zeros(t.hyperplane?t.hyperplane.length:0)})),r=a.zeros(s),o=a.range(s).map((function(){return[-1,-1]})),h=a.range(i).map((function(){return a.range(e).map((function(){return-1}))}));return c(t,n,r,o,h,0,0),new l(n,r,o,h)}(t,n)}))},e.makeLeafArray=function(t){var e,s;if(t.length>0){var i=[];try{for(var o=r(t),a=o.next();!a.done;a=o.next()){var l=a.value;i.push.apply(i,n(l.indices))}}catch(t){e={error:t}}finally{try{a&&!a.done&&(s=o.return)&&s.call(o)}finally{if(e)throw e.error}}return i}return[[-1]]},e.searchFlatTree=function(t,e,s){for(var i=0;e.children[i][0]>0;)i=0===d(e.hyperplanes[i],e.offsets[i],t,s)?e.children[i][0]:e.children[i][1];var n=-1*e.children[i][0];return e.indices[n]}},4364:function(t,e,s){"use strict";var i=this&&this.__awaiter||function(t,e,s,i){return new(s||(s=Promise))((function(n,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){t.done?n(t.value):new s((function(e){e(t.value)})).then(o,a)}l((i=i.apply(t,e||[])).next())}))},n=this&&this.__generator||function(t,e){var s,i,n,r,o={label:0,sent:function(){if(1&n[0])throw n[1];return n[1]},trys:[],ops:[]};return r={next:a(0),throw:a(1),return:a(2)},"function"==typeof Symbol&&(r[Symbol.iterator]=function(){return this}),r;function a(r){return function(a){return function(r){if(s)throw new TypeError("Generator is already executing.");for(;o;)try{if(s=1,i&&(n=2&r[0]?i.return:r[0]?i.throw||((n=i.return)&&n.call(i),0):i.next)&&!(n=n.call(i,r[1])).done)return n;switch(i=0,n&&(r=[2&r[0],n.value]),r[0]){case 0:case 1:n=r;break;case 4:return o.label++,{value:r[1],done:!1};case 5:o.label++,i=r[1],r=[0];continue;case 7:r=o.ops.pop(),o.trys.pop();continue;default:if(!((n=(n=o.trys).length>0&&n[n.length-1])||6!==r[0]&&2!==r[0])){o=0;continue}if(3===r[0]&&(!n||r[1]>n[0]&&r[1]<n[3])){o.label=r[1];break}if(6===r[0]&&o.label<n[1]){o.label=n[1],n=r;break}if(n&&o.label<n[2]){o.label=n[2],o.ops.push(r);break}n[2]&&o.ops.pop(),o.trys.pop();continue}r=e.call(t,o)}catch(t){r=[6,t],i=0}finally{s=n=0}if(5&r[0])throw r[1];return{value:r[0]?r[1]:void 0,done:!0}}([r,a])}}},r=this&&this.__read||function(t,e){var s="function"==typeof Symbol&&t[Symbol.iterator];if(!s)return t;var i,n,r=s.call(t),o=[];try{for(;(void 0===e||e-- >0)&&!(i=r.next()).done;)o.push(i.value)}catch(t){n={error:t}}finally{try{i&&!i.done&&(s=r.return)&&s.call(r)}finally{if(n)throw n.error}}return o},o=this&&this.__spread||function(){for(var t=[],e=0;e<arguments.length;e++)t=t.concat(r(arguments[e]));return t},a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e},l=this&&this.__importDefault||function(t){return t&&t.__esModule?t:{default:t}};Object.defineProperty(e,"__esModule",{value:!0});var h=a(s(9378)),c=a(s(5686)),u=a(s(760)),m=a(s(2320)),d=a(s(4517)),p=l(s(9251)),g=1e-5,f=.001,y=function(){function t(t){void 0===t&&(t={});var e=this;this.learningRate=1,this.localConnectivity=1,this.minDist=.1,this.nComponents=2,this.nEpochs=0,this.nNeighbors=15,this.negativeSampleRate=5,this.random=Math.random,this.repulsionStrength=1,this.setOpMixRatio=1,this.spread=1,this.transformQueueSize=4,this.targetMetric="categorical",this.targetWeight=.5,this.targetNNeighbors=this.nNeighbors,this.distanceFn=w,this.isInitialized=!1,this.rpForest=[],this.embedding=[],this.optimizationState=new b;var s=function(s){void 0!==t[s]&&(e[s]=t[s])};s("distanceFn"),s("learningRate"),s("localConnectivity"),s("minDist"),s("nComponents"),s("nEpochs"),s("nNeighbors"),s("negativeSampleRate"),s("random"),s("repulsionStrength"),s("setOpMixRatio"),s("spread"),s("transformQueueSize")}return t.prototype.fit=function(t){return this.initializeFit(t),this.optimizeLayout(),this.embedding},t.prototype.fitAsync=function(t,e){return void 0===e&&(e=function(){return!0}),i(this,void 0,void 0,(function(){return n(this,(function(s){switch(s.label){case 0:return this.initializeFit(t),[4,this.optimizeLayoutAsync(e)];case 1:return s.sent(),[2,this.embedding]}}))}))},t.prototype.setSupervisedProjection=function(t,e){void 0===e&&(e={}),this.Y=t,this.targetMetric=e.targetMetric||this.targetMetric,this.targetWeight=e.targetWeight||this.targetWeight,this.targetNNeighbors=e.targetNNeighbors||this.targetNNeighbors},t.prototype.setPrecomputedKNN=function(t,e){this.knnIndices=t,this.knnDistances=e},t.prototype.initializeFit=function(t){if(t.length<=this.nNeighbors)throw new Error("Not enough data points ("+t.length+") to create nNeighbors: "+this.nNeighbors+". Add more data points or adjust the configuration.");if(this.X===t&&this.isInitialized)return this.getNEpochs();if(this.X=t,!this.knnIndices&&!this.knnDistances){var e=this.nearestNeighbors(t);this.knnIndices=e.knnIndices,this.knnDistances=e.knnDistances}this.graph=this.fuzzySimplicialSet(t,this.nNeighbors,this.setOpMixRatio),this.makeSearchFns(),this.searchGraph=this.makeSearchGraph(t),this.processGraphForSupervisedProjection();var s=this.initializeSimplicialSetEmbedding(),i=s.head,n=s.tail,r=s.epochsPerSample;return this.optimizationState.head=i,this.optimizationState.tail=n,this.optimizationState.epochsPerSample=r,this.initializeOptimization(),this.prepareForOptimizationLoop(),this.isInitialized=!0,this.getNEpochs()},t.prototype.makeSearchFns=function(){var t=u.makeInitializations(this.distanceFn),e=t.initFromTree,s=t.initFromRandom;this.initFromTree=e,this.initFromRandom=s,this.search=u.makeInitializedNNSearch(this.distanceFn)},t.prototype.makeSearchGraph=function(t){for(var e=this.knnIndices,s=this.knnDistances,i=[t.length,t.length],n=new c.SparseMatrix([],[],[],i),r=0;r<e.length;r++)for(var o=e[r],a=s[r],l=0;l<o.length;l++){var h=o[l],u=a[l];u>0&&n.set(r,h,u)}var m=c.transpose(n);return c.maximum(n,m)},t.prototype.transform=function(t){var e=this,s=this.X;if(void 0===s||0===s.length)throw new Error("No data has been fit.");var i=Math.floor(this.nNeighbors*this.transformQueueSize);i=Math.min(s.length,i);var n=u.initializeSearch(this.rpForest,s,t,i,this.initFromRandom,this.initFromTree,this.random),r=this.search(s,this.searchGraph,n,t),o=h.deheapSort(r),a=o.indices,l=o.weights;a=a.map((function(t){return t.slice(0,e.nNeighbors)})),l=l.map((function(t){return t.slice(0,e.nNeighbors)}));var m=Math.max(0,this.localConnectivity-1),p=this.smoothKNNDistance(l,this.nNeighbors,m),g=p.sigmas,f=p.rhos,y=this.computeMembershipStrengths(a,l,g,f),w=y.rows,b=y.cols,v=y.vals,C=[t.length,s.length],S=new c.SparseMatrix(w,b,v,C),M=c.normalize(S,"l1"),A=c.getCSR(M),E=t.length,x=T(d.reshape2d(A.indices,E,this.nNeighbors),d.reshape2d(A.values,E,this.nNeighbors),this.embedding),N=this.nEpochs?this.nEpochs/3:S.nRows<=1e4?100:30,L=S.getValues().reduce((function(t,e){return e>t?e:t}),0);S=S.map((function(t){return t<L/N?0:t})),S=c.eliminateZeros(S);var I=this.makeEpochsPerSample(S.getValues(),N),_=S.getRows(),R=S.getCols();return this.assignOptimizationStateParameters({headEmbedding:x,tailEmbedding:this.embedding,head:_,tail:R,currentEpoch:0,nEpochs:N,nVertices:S.getDims()[1],epochsPerSample:I}),this.prepareForOptimizationLoop(),this.optimizeLayout()},t.prototype.processGraphForSupervisedProjection=function(){var t=this.Y,e=this.X;if(t){if(t.length!==e.length)throw new Error("Length of X and y must be equal");if("categorical"===this.targetMetric){var s=this.targetWeight<1?1/(1-this.targetWeight)*2.5:1e12;this.graph=this.categoricalSimplicialSetIntersection(this.graph,t,s)}}},t.prototype.step=function(){var t=this.optimizationState.currentEpoch;return t<this.getNEpochs()&&this.optimizeLayoutStep(t),this.optimizationState.currentEpoch},t.prototype.getEmbedding=function(){return this.embedding},t.prototype.nearestNeighbors=function(t){var e,s=this.distanceFn,i=this.nNeighbors,n=u.makeNNDescent(s,this.random),r=5+Math.floor(.5==(e=Math.pow(t.length,.5)/20)?0:Math.round(e)),o=Math.max(5,Math.floor(Math.round(function(t){return Math.log(t)/Math.log(2)}(t.length))));this.rpForest=m.makeForest(t,i,r,this.random);var a=n(t,m.makeLeafArray(this.rpForest),i,o);return{knnIndices:a.indices,knnDistances:a.weights}},t.prototype.fuzzySimplicialSet=function(t,e,s){void 0===s&&(s=1);var i=this,n=i.knnIndices,r=void 0===n?[]:n,o=i.knnDistances,a=void 0===o?[]:o,l=i.localConnectivity,h=this.smoothKNNDistance(a,e,l),u=h.sigmas,m=h.rhos,d=this.computeMembershipStrengths(r,a,u,m),p=d.rows,g=d.cols,f=d.vals,y=[t.length,t.length],w=new c.SparseMatrix(p,g,f,y),b=c.transpose(w),v=c.pairwiseMultiply(w,b),C=c.subtract(c.add(w,b),v),S=c.multiplyScalar(C,s),M=c.multiplyScalar(v,1-s);return c.add(S,M)},t.prototype.categoricalSimplicialSetIntersection=function(t,e,s,i){void 0===i&&(i=1);var n=M(t,e,i,s);return A(n=c.eliminateZeros(n))},t.prototype.smoothKNNDistance=function(t,e,s,i,n){void 0===s&&(s=1),void 0===i&&(i=64),void 0===n&&(n=1);for(var r=Math.log(e)/Math.log(2)*n,o=d.zeros(t.length),a=d.zeros(t.length),l=0;l<t.length;l++){var h=0,c=1/0,u=1,m=t[l],p=m.filter((function(t){return t>0}));if(p.length>=s){var y=Math.floor(s),w=s-y;y>0?(o[l]=p[y-1],w>g&&(o[l]+=w*(p[y]-p[y-1]))):o[l]=w*p[0]}else p.length>0&&(o[l]=d.max(p));for(var b=0;b<i;b++){for(var v=0,C=1;C<t[l].length;C++){var S=t[l][C]-o[l];v+=S>0?Math.exp(-S/u):1}if(Math.abs(v-r)<g)break;v>r?u=(h+(c=u))/2:(h=u,c===1/0?u*=2:u=(h+c)/2)}if(a[l]=u,o[l]>0){var M=d.mean(m);a[l]<f*M&&(a[l]=f*M)}else{var A=d.mean(t.map(d.mean));a[l]<f*A&&(a[l]=f*A)}}return{sigmas:a,rhos:o}},t.prototype.computeMembershipStrengths=function(t,e,s,i){for(var n=t.length,r=t[0].length,o=d.zeros(n*r),a=d.zeros(n*r),l=d.zeros(n*r),h=0;h<n;h++)for(var c=0;c<r;c++){var u=0;-1!==t[h][c]&&(u=t[h][c]===h?0:e[h][c]-i[h]<=0?1:Math.exp(-(e[h][c]-i[h])/s[h]),o[h*r+c]=h,a[h*r+c]=t[h][c],l[h*r+c]=u)}return{rows:o,cols:a,vals:l}},t.prototype.initializeSimplicialSetEmbedding=function(){for(var t=this,e=this.getNEpochs(),s=this.nComponents,i=this.graph.getValues(),n=0,r=0;r<i.length;r++){var o=i[r];n<i[r]&&(n=o)}var a=this.graph.map((function(t){return t<n/e?0:t}));this.embedding=d.zeros(a.nRows).map((function(){return d.zeros(s).map((function(){return 20*d.tauRand(t.random)-10}))}));var l=[],h=[],c=[],u=a.getAll();for(r=0;r<u.length;r++){var m=u[r];m.value&&(l.push(m.value),c.push(m.row),h.push(m.col))}return{head:h,tail:c,epochsPerSample:this.makeEpochsPerSample(l,e)}},t.prototype.makeEpochsPerSample=function(t,e){var s=d.filled(t.length,-1),i=d.max(t),n=t.map((function(t){return t/i*e}));return n.forEach((function(t,i){t>0&&(s[i]=e/n[i])})),s},t.prototype.assignOptimizationStateParameters=function(t){Object.assign(this.optimizationState,t)},t.prototype.prepareForOptimizationLoop=function(){var t=this,e=t.repulsionStrength,s=t.learningRate,i=t.negativeSampleRate,n=this.optimizationState,r=n.epochsPerSample,a=n.headEmbedding,l=n.tailEmbedding,h=a[0].length,c=a.length===l.length,u=r.map((function(t){return t/i})),m=o(u),d=o(r);this.assignOptimizationStateParameters({epochOfNextSample:d,epochOfNextNegativeSample:m,epochsPerNegativeSample:u,moveOther:c,initialAlpha:s,alpha:s,gamma:e,dim:h})},t.prototype.initializeOptimization=function(){var t=this.embedding,e=this.embedding,s=this.optimizationState,i=s.head,n=s.tail,r=s.epochsPerSample,o=this.getNEpochs(),a=this.graph.nCols,l=S(this.spread,this.minDist),h=l.a,c=l.b;this.assignOptimizationStateParameters({headEmbedding:t,tailEmbedding:e,head:i,tail:n,epochsPerSample:r,a:h,b:c,nEpochs:o,nVertices:a})},t.prototype.optimizeLayoutStep=function(t){for(var e=this.optimizationState,s=e.head,i=e.tail,n=e.headEmbedding,r=e.tailEmbedding,o=e.epochsPerSample,a=e.epochOfNextSample,l=e.epochOfNextNegativeSample,h=e.epochsPerNegativeSample,c=e.moveOther,u=e.initialAlpha,m=e.alpha,p=e.gamma,g=e.a,f=e.b,y=e.dim,w=e.nEpochs,b=e.nVertices,S=0;S<o.length;S++)if(!(a[S]>t)){var M=s[S],A=i[S],T=n[M],E=r[A],x=C(T,E),N=0;x>0&&(N=-2*g*f*Math.pow(x,f-1),N/=g*Math.pow(x,f)+1);for(var L=0;L<y;L++){var I=v(N*(T[L]-E[L]),4);T[L]+=I*m,c&&(E[L]+=-I*m)}a[S]+=o[S];for(var _=Math.floor((t-l[S])/h[S]),R=0;R<_;R++){var O=d.tauRandInt(b,this.random),k=r[O],P=C(T,k),G=0;if(P>0)G=2*p*f,G/=(.001+P)*(g*Math.pow(P,f)+1);else if(M===O)continue;for(L=0;L<y;L++)I=4,G>0&&(I=v(G*(T[L]-k[L]),4)),T[L]+=I*m}l[S]+=_*h[S]}return e.alpha=u*(1-t/w),e.currentEpoch+=1,n},t.prototype.optimizeLayoutAsync=function(t){var e=this;return void 0===t&&(t=function(){return!0}),new Promise((function(s,r){var o=function(){return i(e,void 0,void 0,(function(){var e,i,a,l,h,c;return n(this,(function(n){try{if(e=this.optimizationState,i=e.nEpochs,a=e.currentEpoch,this.embedding=this.optimizeLayoutStep(a),l=this.optimizationState.currentEpoch,h=!1===t(l),c=l===i,h||c)return[2,s(c)];setTimeout((function(){return o()}),0)}catch(t){r(t)}return[2]}))}))};setTimeout((function(){return o()}),0)}))},t.prototype.optimizeLayout=function(t){void 0===t&&(t=function(){return!0});for(var e=!1,s=[];!e;){var i=this.optimizationState,n=i.nEpochs,r=i.currentEpoch;s=this.optimizeLayoutStep(r);var o=this.optimizationState.currentEpoch,a=!1===t(o);e=o===n||a}return s},t.prototype.getNEpochs=function(){var t=this.graph;if(this.nEpochs>0)return this.nEpochs;var e=t.nRows;return e<=2500?500:e<=5e3?400:e<=7500?300:200},t}();function w(t,e){for(var s=0,i=0;i<t.length;i++)s+=Math.pow(t[i]-e[i],2);return Math.sqrt(s)}e.UMAP=y,e.euclidean=w,e.cosine=function(t,e){for(var s=0,i=0,n=0,r=0;r<t.length;r++)s+=t[r]*e[r],i+=Math.pow(t[r],2),n+=Math.pow(e[r],2);return 0===i&&0===n?0:0===i||0===n?1:1-s/Math.sqrt(i*n)};var b=function(){this.currentEpoch=0,this.headEmbedding=[],this.tailEmbedding=[],this.head=[],this.tail=[],this.epochsPerSample=[],this.epochOfNextSample=[],this.epochOfNextNegativeSample=[],this.epochsPerNegativeSample=[],this.moveOther=!0,this.initialAlpha=1,this.alpha=1,this.gamma=1,this.a=1.5769434603113077,this.b=.8950608779109733,this.dim=2,this.nEpochs=500,this.nVertices=0};function v(t,e){return t>e?e:t<-e?-e:t}function C(t,e){for(var s=0,i=0;i<t.length;i++)s+=Math.pow(t[i]-e[i],2);return s}function S(t,e){var s=d.linear(0,3*t,300).map((function(t){return t<e?1:t})),i=d.zeros(s.length).map((function(i,n){return s[n]>=e?Math.exp(-(s[n]-e)/t):i})),n={x:s,y:i},o=p.default(n,(function(t){var e=r(t,2),s=e[0],i=e[1];return function(t){return 1/(1+s*Math.pow(t,2*i))}}),{damping:1.5,initialValues:[.5,.5],gradientDifference:.1,maxIterations:100,errorTolerance:.01}).parameterValues,a=r(o,2);return{a:a[0],b:a[1]}}function M(t,e,s,i){return void 0===s&&(s=1),void 0===i&&(i=5),t.map((function(t,n,r){return-1===e[n]||-1===e[r]?t*Math.exp(-s):e[n]!==e[r]?t*Math.exp(-i):t}))}function A(t){t=c.normalize(t,"max");var e=c.transpose(t),s=c.pairwiseMultiply(e,t);return t=c.add(t,c.subtract(e,s)),c.eliminateZeros(t)}function T(t,e,s){for(var i=d.zeros(t.length).map((function(t){return d.zeros(s[0].length)})),n=0;n<t.length;n++)for(var r=0;r<t[0].length;r++)for(var o=0;o<s[0].length;o++){var a=t[n][r];i[n][o]+=e[n][r]*s[a][o]}return i}e.findABParams=S,e.fastIntersection=M,e.resetLocalConnectivity=A,e.initTransform=T},4517:function(t,e){"use strict";var s=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}};function i(t,e){return Math.floor(e()*t)}function n(t){for(var e=[],s=0;s<t;s++)e.push(void 0);return e}function r(t,e){return n(t).map((function(){return e}))}function o(t){return r(t,0)}function a(t){return t.reduce((function(t,e){return t+e}))}Object.defineProperty(e,"__esModule",{value:!0}),e.tauRandInt=i,e.tauRand=function(t){return t()},e.norm=function(t){var e,i,n=0;try{for(var r=s(t),o=r.next();!o.done;o=r.next()){var a=o.value;n+=Math.pow(a,2)}}catch(t){e={error:t}}finally{try{o&&!o.done&&(i=r.return)&&i.call(r)}finally{if(e)throw e.error}}return Math.sqrt(n)},e.empty=n,e.range=function(t){return n(t).map((function(t,e){return e}))},e.filled=r,e.zeros=o,e.ones=function(t){return r(t,1)},e.linear=function(t,e,s){return n(s).map((function(i,n){return t+n*((e-t)/(s-1))}))},e.sum=a,e.mean=function(t){return a(t)/t.length},e.max=function(t){for(var e=0,s=0;s<t.length;s++)e=t[s]>e?t[s]:e;return e},e.max2d=function(t){for(var e=0,s=0;s<t.length;s++)for(var i=0;i<t[s].length;i++)e=t[s][i]>e?t[s][i]:e;return e},e.rejectionSample=function(t,e,s){for(var n=o(t),r=0;r<t;r++)for(var a=!0;a;){for(var l=i(e,s),h=!1,c=0;c<r;c++)if(l===n[c]){h=!0;break}h||(a=!1),n[r]=l}return n},e.reshape2d=function(t,e,s){var i=[],n=0;if(t.length!==e*s)throw new Error("Array dimensions must match input length.");for(var r=0;r<e;r++){for(var o=[],a=0;a<s;a++)o.push(t[n]),n+=1;i.push(o)}return i}},3336:t=>{"use strict";t.exports=$},976:t=>{"use strict";t.exports=DG},4469:t=>{"use strict";t.exports=grok},701:t=>{"use strict";t.exports=rxjs},3870:t=>{"use strict";t.exports=ui},6414:t=>{"use strict";t.exports=wu}},e={};function s(i){var n=e[i];if(void 0!==n)return n.exports;var r=e[i]={id:i,exports:{}};return t[i].call(r.exports,r,r.exports,s),r.exports}s.m=t,s.n=t=>{var e=t&&t.__esModule?()=>t.default:()=>t;return s.d(e,{a:e}),e},s.d=(t,e)=>{for(var i in e)s.o(e,i)&&!s.o(t,i)&&Object.defineProperty(t,i,{enumerable:!0,get:e[i]})},s.u=t=>t+".js",s.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(t){if("object"==typeof window)return window}}(),s.o=(t,e)=>Object.prototype.hasOwnProperty.call(t,e),s.r=t=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(t,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(t,"__esModule",{value:!0})},(()=>{var t;s.g.importScripts&&(t=s.g.location+"");var e=s.g.document;if(!t&&e&&(e.currentScript&&(t=e.currentScript.src),!t)){var i=e.getElementsByTagName("script");if(i.length)for(var n=i.length-1;n>-1&&!t;)t=i[n--].src}if(!t)throw new Error("Automatic publicPath is not supported in this browser");t=t.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),s.p=t})(),s.b=document.baseURI||self.location.href,s.nc=void 0;var i=s(2140);bio=i})();
1
+ var bio;(()=>{var t={7997:(t,e,s)=>{"use strict";function n(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function i(t){let e=0;for(let s=0;s<t.length;s++)e+=t[s]*t[s];return Math.sqrt(e)}function r(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let s=0;for(let n=0;n<t.length;n++)s+=t[n]*e[n];return s}s.d(e,{$G:()=>i,MA:()=>r,hu:()=>n})},2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>i});var n=s(9976);class i extends n.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,i)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,i)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new i({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in i.aaSynonyms?i.aaSynonyms[t]:t;return super.get(e)}}i.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return i.GrokGroups;case"lesk":return i.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",n="";for(const i of t)"("==i?e++:")"==i?e--:e?s+=i:n+=i;return isNaN(parseInt(s))?[n,s]:[n,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[n,i]=this.getInnerOuter(t);if(n=n.length>6?`${n.slice(0,3)}...`:n,i=i.length>6?`${i.slice(0,3)}...`:i,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,i,1]:[this.undefinedColor,n,i,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,i,2]:[this.undefinedColor,n,i,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,i,3]:[this.undefinedColor,n,i,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,i,4]:[this.undefinedColor,n,i,4]}return[this.undefinedColor,n,i,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>l,Qx:()=>h,Xk:()=>a});var n=s(976),i=s(4469),r=s(1047),o=(s(499),s(8457));function a(t){const e=[];for(let s=0;s<t.rowCount;s++){const n={};Object.keys(r.K4).forEach((e=>{if("symbol"===e){const i=t.get(r.K4[e],s);n[e]="."===i?t.get(r.At,s):i}else if("rgroups"===e){const i=t.get(r.K4[e],s).split("\n"),o=[];i.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),n=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${n}][H]`:`O[*:${n}]`,e.alternateId="H"===s?`R${n}-H`:`R${n}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${n}`,o.push(e)})),n[e]=o}else r.K4[e]&&(n[e]=t.get(r.K4[e],s))})),e.push(n)}return e}async function l(){const t=n.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function h(t,e){t instanceof n.Column&&(t=(0,o.O)(t).columns.toList());const s=(await l()).getBioLib(),r=new Array(t.length),a=t[0].length,h=new Float32Array(a);for(let o=0;o<t.length;++o){const l=e[o],c=s.getMonomer("PEPTIDE",l)?.smiles??"",u=t[o],m=u.getRawData(),d=u.categories,p=d.indexOf("");if(r[o]={categories:d,data:m,emptyIndex:p},void 0===l)continue;const g=n.Column.fromStrings("smiles",d.map((t=>s.getMonomer("PEPTIDE",t)?.smiles??""))),f=(n.DataFrame.fromColumns([g]),(await i.chem.getSimilarities(g,c)).getRawData());for(let t=0;t<a;++t){const e=m[t];h[t]+=""!==l&&e!==p?f[e]:""===l&&e===p?1:0}}for(let s=0;s<h.length;++s){let i=h[s]/e.length;for(let o=0;o<t.length;++o){const t=r[o];if(o>=e.length&&t.data[s]!==t.emptyIndex||t.data[s]===t.emptyIndex&&o<e.length){i=n.FLOAT_NULL;break}}h[s]=i}return n.Column.fromFloat32Array("Similarity",h)}},8601:(t,e,s)=>{"use strict";s.d(e,{i0:()=>m});var n=s(4469),i=s(976),r=s(6414),o=s.n(r),a=s(1821),l=s(499);const h={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG:",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var c=s(1047);function u(t){return Math.round(h.PRECISION_FACTOR*t)/h.PRECISION_FACTOR}async function m(t,e,r){if(0===i.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(e.semType!==i.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${i.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let u=e;const m=l.Cn.getOrCreate(e);m.isHelm()&&(u=m.convert(a.r2.SEPARATOR,"."),u.name=e.name);const p=l.Cn.getOrCreate(u).alphabet;let g;if("PT"===p||"UN"===p)g="PEPTIDE";else{if("RNA"!==p&&"DNA"!==p)return{col:null,warnings:[`Unexpected column's '${u.name}' alphabet '${p}'.`]};g="RNA"}const f=function(t){const e=t.length,s=new Array(e),n=l.Cn.getOrCreate(t).getSplitter();for(let i=0;i<e;++i){const e=t.get(i);s[i]=e?o()(n(e)).filter((t=>""!==t)).toArray():[]}return s}(u),y=await async function(t,e,s,i){const r=function(t,e,s){const n=new Map;for(const i of t.getMonomerSymbolsByType(e)){const r=t.getMonomer(e,i);if("RNA"===e&&("Branch"===r.monomerType||"DNA"===s&&r.symbol===h.DEOXYRIBOSE||"RNA"===s&&r.symbol===h.RIBOSE||r.symbol===h.PHOSPHATE)||"PEPTIDE"===e&&"Branch"!==r.monomerType){const t={};c.rx.forEach((e=>{t[e]=r[e]})),n.set(r.symbol,t)}}return n}(e,s,i),o=new Map,a=await n.functions.call("Chem:getRdKitModule"),l={value:null};if("RNA"===s){const t="RNA"===i?[h.RIBOSE,h.PHOSPHATE]:[h.DEOXYRIBOSE,h.PHOSPHATE];for(const e of t)d(o,e,r,a,s,l)}for(let e=0;e<t.length;++e){const n=t[e];for(const t of n)if(""!==t)try{d(o,t,r,a,s,l)}catch(e){const s=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n${s}\n${n}`),new Error(`Can't get monomer '${t}' from library: ${s}`)}}return o}(f,r,g,p),w=u.length,{molfileList:b,molfileWarningList:v}=await async function(t,e,n,i,r){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=r/o;let h=[],c=[];const u=new Array(o);for(let s=0;s<o;s++){const h=Math.floor(s*l),c=s===o-1?r:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:n,polymerType:i,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(f,y,p,g,w);if(v.length>.05*w)throw new Error("Too many errors getting molfiles.");const C=`molfile(${u.name})`,S=t.columns.getUnusedName(C),M=i.Column.fromStrings(S,b);return M.semType=i.SEMTYPE.MOLECULE,M.setTag(i.TAGS.UNITS,i.UNITS.Molecule.MOLBLOCK),{col:M,warnings:v}}function d(t,e,s,n,i,r){if(!t.has(e)){const o=function(t,e,s,n,i){if(e.has(t)){const r=e.get(t),o=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(r.rgroups),a=function(t){const e=new Map;let s=t.indexOf(h.V2K_A_LINE,0),n=s;for(;-1!==s;){n=t.indexOf("\n",s);const i=parseInt(t.substring(s,n).replace(/^A\s+/,""));s=t.indexOf("R",n),n=t.indexOf("\n",s);const r=parseInt(t.substring(s,n).replace(/^R/,""));e.set(i,r),s=t.indexOf(h.V2K_A_LINE,n)}for(s=t.indexOf(h.V2K_RGP_LINE,0),n=t.indexOf("\n",s);-1!==s;){s+=h.V2K_RGP_SHIFT,n=t.indexOf("\n",s);const i=t.substring(s,n).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<i.length;t+=2){if(e.has(i[t])&&e.get(i[t])!==i[t+1])throw new Error(`r-group index ${i[t]} has already been added with a different value`);e.set(i[t],i[t+1])}s=t.indexOf(h.V2K_RGP_LINE,n)}return e}(r.molfile),l=function(t,e){const s=e.get_mol(t),n=s.get_v3Kmolblock();return s.delete(),n}(function(t){let e=t.indexOf(h.V2K_A_LINE,0);-1===e&&(e=t.indexOf(h.V2K_RGP_LINE));const s=t.indexOf(h.V3K_END,e);return t.substring(0,e)+t.substring(s)}(r.molfile),s),c=function(t){let e=(t=t.replaceAll("\r","")).indexOf(h.V3K_BEGIN_COUNTS_LINE)+h.V3K_COUNTS_SHIFT,s=t.indexOf(" ",e+1);const n=parseInt(t.substring(e,s));return e=s+1,s=t.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(t.substring(e,s))}}(l),m=function(t,e){const s=new Array(e),n=new Float32Array(e),i=new Float32Array(e),r=new Array(e);let o=t.indexOf(h.V3K_BEGIN_ATOM_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;l++){o=t.indexOf(h.V3K_BEGIN_DATA_LINE,o)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",o),o=a+1,a=t.indexOf(" ",o),s[l]=t.substring(o,a);const e=new Array(2);for(let s=0;s<2;++s)o=a+1,a=t.indexOf(" ",o),e[s]=parseFloat(t.substring(o,a));n[l]=e[0],i[l]=e[1],o=a,a=t.indexOf("\n",o)+1,r[l]=t.slice(o,a),o=a}return{atomTypes:s,x:n,y:i,kwargs:r}}(l,c.atomCount),d=function(t,e){const s=new Uint32Array(e),n=new Array(e),i=new Map,r=new Map;let o=t.indexOf(h.V3K_BEGIN_BOND_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;++l){const e=new Array(3);o=t.indexOf(h.V3K_BEGIN_DATA_LINE,a)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",o);for(let s=0;s<3;++s)o=a+1,a=Math.min(t.indexOf("\n",o),t.indexOf(" ",o)),e[s]=parseInt(t.slice(o,a));s[l]=e[0],n[l]=e.slice(1);const c=t.indexOf("\n",o);let u=t.slice(a,c),m=u.indexOf(h.V3K_BOND_CONFIG);if(-1!==m){m=u.indexOf("=",m)+1;let t=u.indexOf(" ",m);-1===t&&(t=u.length);const e=parseInt(u.slice(m,t));i.set(l,e);const s=h.V3K_BOND_CONFIG+e.toString();u=u.replace(s,"")}u||r.set(l,u)}return{bondTypes:s,atomPairs:n,bondConfiguration:i,kwargs:r}}(l,c.bondCount),y={atoms:m,bonds:d,meta:p(m,d,o,a)};return"PEPTIDE"===n?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,n=t.atoms.x,i=t.atoms.y;M(t,-n[e],-i[e]);const r=v(n[s],i[s]);C(t.atoms,-r),n[t.meta.rNodes[1]-1]<0&&function(t){S(t,!1)}(t);const o=function(t){const e=function(t){const e=new Map;for(const s of t.bonds.atomPairs)for(let t=0;t<2;t++){const n=s[t],i=s[(t+1)%2];e.has(n)?e.get(n)?.push(i):e.set(n,new Array(1).fill(i))}return e}(t);let s=0,n=0;for(;0===s;){const i=e.get(t.meta.terminalNodes[1])[n];t.atoms.atomTypes[i-1]===h.OXYGEN&&i!==t.meta.rNodes[1]&&(s=i),n++}return s}(t);!function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){S(t,!0)}(t),C(t.atoms,-function(t,e){return v(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,o),function(t,e){const s=t.atoms.x;s[t.meta.rNodes[1]-1]>s[e-1]&&function(t,e,s){const n=e-1,i=s-1,r=t.atoms.x,o=t.atoms.y,a=r[n],l=o[n];r[n]=r[i],o[n]=o[i],r[i]=a,o[i]=l}(t,e,t.meta.rNodes[1])}(t,o)}(y):t===h.RIBOSE||t===h.DEOXYRIBOSE?function(t,e){const s=t.atoms.x,n=t.atoms.y;let i=t.meta.terminalNodes[0]-1;const r=t.meta.rNodes[1]-1;M(t,-s[i],-n[i]);const o=v(s[r],n[r]);C(t.atoms,3*Math.PI/2-o),e.value=function(t){const e=t.atoms.x,s=t.atoms.y,n=t.meta.rNodes[2]-1,i=t.meta.terminalNodes[2]-1,r=e[n]-e[i],o=s[n]-s[i];return Math.atan(o/r)+Math.PI/2}(t),i=t.meta.terminalNodes[0]-1,M(t,-s[i],-n[i])}(y,i):t===h.PHOSPHATE?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,n=t.atoms.x,i=t.atoms.y;M(t,-n[e],-i[e]);const r=v(n[s],i[s]);C(t.atoms,Math.PI/2-r)}(y):function(t,e){const s=t.atoms.x,n=t.atoms.y,i=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;M(t,-s[i],-n[i]);const o=v(s[r],n[r]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");C(t.atoms,Math.PI-o+a);const l=function(t,e){return u(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:s[t.meta.rNodes[0]-1],y:n[t.meta.rNodes[0]-1]},{x:s[t.meta.terminalNodes[0]-1],y:n[t.meta.terminalNodes[0]-1]});if(1!=l)for(let t=0;t<s.length;++t)s[t]=u(s[t]/l),n[t]=u(n[t]/l)}(y,i),function(t,e,s){"PEPTIDE"===t?(f(e,t),w(e,e.meta.rNodes[1])):s===h.RIBOSE||s===h.DEOXYRIBOSE?(w(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],g(e.bonds,e.meta),f(e,t),w(e,e.meta.rNodes[1]),w(e,e.meta.rNodes[0]),w(e,e.meta.rNodes[2])):s===h.PHOSPHATE&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],M(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),f(e,t),w(e,e.meta.rNodes[1]))}(n,y,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===h.HYDROGEN&&(w(t,e+1),--e),++e}(y),y}return null}(e,s,n,i,r);if(!o)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);t.set(e,o)}}function p(t,e,s,n){const i={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(t,e,s){for(const[n,i]of s)t.atomTypes[n-1]=e[i-1]}(t,s,n),function(t,e){e.rNodes=Array.from(t.keys());for(let s=0;s<e.rNodes.length;s++)for(const n of[1,2])if(t.get(e.rNodes[s])===n){const t=e.rNodes[n-1];e.rNodes[n-1]=e.rNodes[s],e.rNodes[s]=t}}(n,i),g(e,i),i}function g(t,e){const s=e.rNodes;e.terminalNodes=new Array(s.length).fill(0);const n=e.terminalNodes,i=t.atomPairs;let r=0,o=0;for(;r<i.length&&o<n.length;){for(let t=0;t<n.length;++t)for(let e=0;e<2;++e)i[r][e]===s[t]&&(n[t]=i[r][(e+1)%2],s.length,++o);++r}}function f(t,e){t.meta.rNodes.length>1&&(t.meta.backboneShift=y(t,t.meta.rNodes[1]-1,t.meta.terminalNodes[0]-1)),"RNA"===e&&t.meta.rNodes.length>2&&(t.meta.branchShift=y(t,t.meta.rNodes[2]-1,t.meta.terminalNodes[0]-1))}function y(t,e,s){return[u(t.atoms.x[e]-t.atoms.x[s]),u(t.atoms.y[e]-t.atoms.y[s])]}function w(t,e){if(void 0!==e){const s=e-1,n=t.atoms,i=t.bonds,r=t.meta;n.atomTypes.splice(s,1),n.x=b(Float32Array,n.x,s,1),n.y=b(Float32Array,n.y,s,1),n.kwargs.splice(s,1);for(let t=0;t<r.terminalNodes.length;++t)r.terminalNodes[t]>e?--r.terminalNodes[t]:r.terminalNodes[t]===e&&(r.terminalNodes[t]=-1);for(let t=0;t<r.rNodes.length;++t)r.rNodes[t]>e?--r.rNodes[t]:r.rNodes[t]===e&&(r.rNodes[t]=-1);let o=0;for(;o<i.atomPairs.length;){const t=i.atomPairs[o][0],s=i.atomPairs[o][1];t===e||s===e?(i.atomPairs.splice(o,1),i.bondTypes=b(Uint32Array,i.bondTypes,o,1),i.bondConfiguration.has(o)&&i.bondConfiguration.delete(o),i.kwargs.has(o)&&i.kwargs.delete(o),--o):(i.atomPairs[o][0]=t>e?t-1:t,i.atomPairs[o][1]=s>e?s-1:s),++o}let a=Array.from(i.bondConfiguration.keys());a.forEach((t=>{if(i.bondConfiguration.has(t)&&t>s){const e=i.bondConfiguration.get(t);i.bondConfiguration.delete(t),i.bondConfiguration.set(t-1,e)}})),a=Array.from(i.kwargs.keys()),a.forEach((t=>{if(i.kwargs.has(t)&&t>s){const e=i.kwargs.get(t);i.kwargs.delete(t),i.kwargs.set(t-1,e)}}))}}function b(t,e,s,n){const i=new t(e.length-n);let r=0,o=0;for(;r<e.length;)r===s&&(r+=n),i[o]=e[r],++o,++r;return i}function v(t,e){let s;if(0===t)s=e>0?0:Math.PI;else if(0===e)s=t>0?-Math.PI/2:Math.PI/2;else{const n=e/t,i=Math.atan(n);s=t<0?Math.PI/2+i:-Math.PI/2+i}return s}function C(t,e){if(0!==e){const s=t.x,n=t.y,i=Math.cos(e),r=Math.sin(e);for(let t=0;t<s.length;++t){const e=s[t];s[t]=u(e*i-n[t]*r),n[t]=u(e*r+n[t]*i)}}}function S(t,e){if(e){const e=t.atoms.y;for(let t=0;t<e.length;t++)e[t]=-e[t]}else{const e=t.atoms.x;for(let t=0;t<e.length;t++)e[t]=-e[t]}const s=t.bonds.bondConfiguration;for(const[t,e]of s){const n=1===e?3:1;s.set(t,n)}}function M(t,e,s){const n=t.atoms.x,i=t.atoms.y;for(let t=0;t<n.length;++t)n[t]=u(n[t]+e),void 0!==s&&(i[t]=u(i[t]+s))}},6137:(t,e,s)=>{"use strict";s.d(e,{J:()=>i});var n=s(9976);class i extends n.B{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new i({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class r{}r.SemType="Nucleotides",r.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",r.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},9976:(t,e,s)=>{"use strict";s.d(e,{B:()=>n});class n{static makePalette(t,e=!1,s=n){const i={};return t.forEach((t=>{const s=t[0],n=t[1];s.forEach(((t,s)=>{i[t]=this.colourPalette[n][e?0:s]}))})),new s(i)}constructor(t){this._palette=t}get(t){return this._palette[t]}}n.undefinedColor="rgb(100,100,100)",n.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},7331:(t,e,s)=>{"use strict";s.d(e,{UE:()=>h});var n=s(976),i=s(9976);class r{static hashCode(t){let e=0;if(0===t.length)return e;for(let s=0;s<t.length;s++)e=(e<<5)-e+t.charCodeAt(s),e|=0;return e}}class o{}class a extends o{get(t){return"#666666"}}class l extends o{static buildPalette(){return[].concat(...Object.values(i.B.colourPalette))}get(t){const e=r.hashCode(t)%l.palette.length;return function(t){if(null==t)return"rgb(100,100,100)";const e=n.Color.fromHtml(t),s=n.Color.g(e),i=n.Color.r(e),r=n.Color.b(e),o=Math.sqrt(Math.pow(0-i,2)+Math.pow(0-s,2)+Math.pow(0-r,2));return o>210?`rgb(${i/o*210},${s/o*210},${r/o*210})`:n.Color.toRgb(e)}(l.palette[e])}}l.palette=l.buildPalette();class h extends i.B{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new l),this.color}}},9611:(t,e,s)=>{"use strict";s.d(e,{A:()=>h});var n=s(4469),i=s(976),r=s(6414),o=s.n(r),a=s(8447);const l={DNA:"RNA",RNA:"RNA",PT:"PEPTIDE",UN:"PEPTIDE"};class h{get updated(){return this._updated}constructor(t,e,s){this.grid=t,this.col=e,this.propsProvider=s,this._monomerLengthList=null,this.separatorWidth=5,this._updated=!1,this._monomerLengthMap={},this._monomerStructureMap={},this.subs=[],this._splitter=(0,a.Mj)(this.col),this.props=this.propsProvider(),this._rowsProcessed=i.BitSet.create(this.col.length),this.grid&&(this.subs.push(e.dataFrame.onDataChanged.subscribe((()=>{this.props=this.propsProvider(),this._monomerLengthList=null,this._rowsProcessed=i.BitSet.create(this.col.length)}))),this.subs.push(n.events.onViewRemoved.subscribe((t=>{this.grid?.view?.id===t.id&&this.destroy()}))))}destroy(){for(const t of this.subs)t.unsubscribe()}getCellMonomerLengths(t){const e=this.props.unitsHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t),s=new Array(e.length+1);s[0]=5;for(let t=1;t<s.length;t++)s[t]=s[t-1]+e[t-1];return[e,s]}getCellMonomerLengthsForSeq(t){null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.col.length).fill(null),this._updated=!0);let e=this._monomerLengthList[t];if(null===e){const s=this.getSeqMonList(t);e=this._monomerLengthList[t]=new Array(s.length);for(const[t,n]of o().enumerate(s)){const s=this.props.monomerToShort(t,this.props.monomerLengthLimit),i=(this.props.unitsHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.monomerCharWidth;e[n]=i}this._updated=!0}return e}getCellMonomerLengthsForSeqMsa(){var t;null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null),this._updated=!0),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],s=Math.max(Math.floor((this.grid?.vertScroll.min??0)-10),0),n=Math.min(Math.ceil((this.grid?.vertScroll.max??0)+10),this.col.length);for(let t=s;t<n;t++){if(this._rowsProcessed.get(t))continue;const s=this.getSeqMonList(t);s.length>e.length&&e.push(...new Array(s.length-e.length).fill(0));for(const[t,n]of o().enumerate(s)){const s=this.props.monomerToShort(t,this.props.monomerLengthLimit),i=this.props.separatorWidth+s.length*this.props.monomerCharWidth;e[n]=Math.max(e[n]??0,i)}this._updated=!0}return e}getPosition(t,e){const[s,n]=this.getCellMonomerLengths(t),i=this.col.get(t);let r=100,a=null,l=o()(this._splitter(i)).toArray().length,h=!1,c=0;if(n[0]<=e&&e<n.slice(-1)[0])for(;!h;)if(c=Math.floor((l+(a??0))/2),e>=n[c]&&e<=n[c+1]?(a=c,h=!0):e<n[c]?l=c-1:e>n[c+1]&&(a=c+1),a==l&&(h=!0),--r<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(n)}. `);return a}getSeqMonList(t){const e=this.col.get(t);return e?o()(this._splitter(e)).toArray():[]}getMonomer(t){const e=this.props.unitsHandler.alphabet??"UN",s=l[e];return this.props.monomerLib?.getMonomer(s,t)??null}setMonomerLengthLimit(t){this.props.monomerLengthLimit=t,this._updated=!0}setSeparatorWidth(t){this.props.separatorWidth=t,this._updated=!0}isMsa(){return this.props.unitsHandler.isMsa()}}},1047:(t,e,s)=>{"use strict";s.d(e,{At:()=>i,K4:()=>r,rx:()=>n});const n=["symbol","molfile","rgroups","name"],i="MonomerName",r={monomerType:null,smiles:null,name:"MonomerName",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerCode"}},5226:(t,e,s)=>{"use strict";s.d(e,{i:()=>o});var n=s(976),i=s(499),r=s(1821);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,s=0;for(;e=t.exec(this._fileContent);){const n=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(n),0!==s&&this._sequencesArray.push(this.parseMacromolecule(s,e.index)),s=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(s,-1))}importFasta(){const t=n.Column.fromStrings("description",this.descriptionsArray),e=n.Column.fromStrings("sequence",this.sequencesArray);return e.semType=n.SEMTYPE.MACROMOLECULE,e.setTag(n.TAGS.UNITS,r.r2.FASTA),i.Cn.getOrCreate(e),[n.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},1821:(t,e,s)=>{"use strict";s.d(e,{BM:()=>o,CI:()=>r,XS:()=>l,r2:()=>n});var n,i=s(6286);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm"}(n||(n={}));const r=", ",o=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,a=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},l=[new i.L("PT",a.fasta.peptide,.5),new i.L("DNA",a.fasta.dna,.55),new i.L("RNA",a.fasta.rna,.55)]},8447:(t,e,s)=>{"use strict";s.d(e,{CI:()=>n.CI,GU:()=>i.GU,Mj:()=>i.Mj,XS:()=>n.XS,dQ:()=>i.dQ,kB:()=>i.kB,py:()=>i.py,r2:()=>n.r2,up:()=>i.up});var n=s(1821),i=s(6066)},6286:(t,e,s)=>{"use strict";s.d(e,{L:()=>n,d:()=>i});class n{constructor(t,e,s){this.name=t,this.alphabet=e,this.cutoff=s}}class i extends n{constructor(t,e,s){super(t.name,t.alphabet,t.cutoff),this.freq=e,this.similarity=s}}},6066:(t,e,s)=>{"use strict";s.d(e,{w4:()=>A,py:()=>E,vU:()=>v,Mj:()=>C,Ar:()=>f,GU:()=>M,dQ:()=>T,up:()=>x,kB:()=>p,FJ:()=>g,gP:()=>b});var n=s(976),i=s(6414),r=s.n(i),o=s(6286),a=s(1821),l=s(499);class h extends Float32Array{}var c=s(7997),u=s(2012),m=s(6137),d=s(7331);function p(t){return r()(t.toString().matchAll(a.BM)).map((t=>t[2]??t[1])).toArray()}function g(t){return t||[]}function f(t,e=undefined){return s=>s.split(t,e)}const y=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,w=/\[([^\[\]]+)]/g;function b(t){y.lastIndex=0;const e=y.exec(t.toString()),s=e?e[2]:null;return(s?s.split("."):[]).map((t=>{w.lastIndex=0;const e=w.exec(t);return e&&e.length>=2?e[1]:t}))}function v(t,e,s=undefined){if(t.toLowerCase().startsWith(a.r2.FASTA))return p;if(t.toLowerCase().startsWith(a.r2.SEPARATOR))return f(e,s);if(t.toLowerCase().startsWith(a.r2.HELM))return b;throw new Error(`Unexpected units ${t} .`)}function C(t){return l.Cn.getOrCreate(t).getSplitter()}const S=/([^\W_]+)/g;function M(t,e){if(t.length<=e)return t;const s=t.match(S),n=t.length>e||(s?.length??0)>1,i=s?.[0]??" ";return n?i.substring(0,e-1)+"…":i}function A(t,e,s="-"){const n=e.map((e=>{const n=function(t,e,s="-"){const n=new Set([...new Set(Object.keys(t)),...e]);n.delete(s);const i=[],r=[];for(const s of n)i.push(s in t?t[s]:0),r.push(e.has(s)?1:0);const o=new h(i),a=new h(r);return(0,c.MA)(o,a)/((0,c.$G)(o)*(0,c.$G)(a))}(t,e.alphabet,s);return new o.d(e,t,n)}));let i;const r=Math.max(...n.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return i=r>0?n.find((t=>t.similarity===r)).name:"UN",i}function T(t,e=5){let s;if(t.semType==n.SEMTYPE.MACROMOLECULE)s=l.Cn.getOrCreate(t).alphabet;else{const n=function(t,e,s){return t.categories,function(t,e){const s={};let n=!0,i=null;for(const r of t)if(null==i?i=r.length:r.length!==i&&(n=!1),r.length>=e)for(const t of r)t in s||(s[t]=0),s[t]+=1;return{freq:s,sameLength:n}}(r()(t.getRawData()).map((e=>s(t.categories[e]))),e)}(t,e,p);s=A(n.freq,a.XS)}return E(s)}function E(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return m.J.Chromatogram;default:return d.UE.Color}}function x(t){const e=t.columns.bySemTypeAll(n.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(n.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},8457:(t,e,s)=>{"use strict";s.d(e,{O:()=>a});var n=s(976),i=s(6414),r=s.n(i),o=s(6066);function a(t){const e=(0,o.Mj)(t),s=t=>{const e=l.columns.addNewString((t+1).toString());return i.push(e),e},i=[],a=t.length,l=n.DataFrame.create(a);for(let n=0;n<a;++n){const o=t.get(n);if(null==o)continue;const a=e(o);for(const[t,e]of r().enumerate(a))((i[e]??null)||s(e)).set(n,t||"-",!1)}return l}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>m});var n=s(976),i=s(6414),r=s.n(i),o=s(8447),a=s(6066),l=s(489),h=s(7228);const c=new class{constructor(){this.uhTemp=`units-handler.${n.SEMTYPE.MACROMOLECULE}`}},u={[o.r2.FASTA]:"-",[o.r2.SEPARATOR]:"",[o.r2.HELM]:"*"};class m{static setUnitsToFastaColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||t.column.getTag(n.TAGS.UNITS)!==o.r2.FASTA)throw new Error(`The column of notation '${o.r2.FASTA}' must be '${n.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(n.TAGS.UNITS,o.r2.FASTA),m.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||t.column.getTag(n.TAGS.UNITS)!==o.r2.SEPARATOR)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must be '${n.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(n.TAGS.UNITS,o.r2.SEPARATOR),t.column.setTag("separator",e),m.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${o.r2.HELM}' must be '${n.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(n.TAGS.UNITS,o.r2.HELM),m.setTags(t)}static setTags(t){const e=t.column.getTag(n.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[o.r2.FASTA,o.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");const e=s.sameLength?"SEQ.MSA":"SEQ";t.column.setTag("aligned",e);const n=(0,a.w4)(s.freq,o.XS);if(t.column.setTag("alphabet",n),"UN"===n){const e=Object.keys(s.freq).length,n=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",n?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===o.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==o.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===o.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),n=this._column.categories;for(let i=0;i<e;i++){const e=n[s[i]];this._splitted[i]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const n of this.splitted){null==s?s=n.length:n.length!==s&&(e=!1);for(const e of n)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=Math.max(...this.splitted.map((t=>t.length)))),this._maxLength}get posList(){if(null===this._posList){const t=this.column.getTag(".positionNames");this._posList=t?t.split(o.CI).map((t=>t.trim())):r().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===o.r2.FASTA}isSeparator(){return this.notation===o.r2.SEPARATOR}isHelm(){return this.notation===o.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===o.r2.FASTA&&t===u[o.r2.FASTA]||this.units===o.r2.HELM&&t===u[o.r2.HELM]}getNotation(){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return o.r2.FASTA;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return o.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(o.r2.HELM))return o.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}getNewColumn(t,e){const s=this.column,i=s.length,r=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(r),l=n.Column.fromList("string",a,new Array(i).fill(""));if(l.semType=n.SEMTYPE.MACROMOLECULE,l.setTag(n.TAGS.UNITS,t),t===o.r2.SEPARATOR){if(!e)throw new Error(`Notation '${o.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(n.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");null!=c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");null!=c&&u&&l.setTag(".alphabetSize",u);const m=s.getTag(".alphabetIsMultichar");return null!=c&&void 0!==m&&l.setTag(".alphabetIsMultichar",m),t==o.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=m.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[o.r2.FASTA,o.r2.SEPARATOR,o.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!m.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const i=n.Column.fromList("string",e,new Array(t).fill(""));return i.semType=n.SEMTYPE.MACROMOLECULE,i.setTag(n.TAGS.UNITS,s),i}getSplitter(t){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return null===this.column.getTag("alphabet")||this.getAlphabetIsMultichar()?a.kB:a.FJ;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return(0,a.Ar)(this.separator,t);if(this.units.toLowerCase().startsWith(o.r2.HELM))return a.gP;throw new Error(`Unexpected units ${this.units} .`)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return l.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return l.U.LEVENSHTEIN;case"PT":return l.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return l.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,h.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,a.Ar)(this.separator);for(const t of this.column.categories){const n=s(t);for(const t of n)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===o.r2.FASTA}toSeparator(t){return t===o.r2.SEPARATOR}toHelm(t){return t===o.r2.HELM}convertHelmToFastaSeparator(t,e,s,n){n||(n=this.toFasta(e)?u[o.r2.FASTA]:u[o.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const i=/(R\(|D\(|\)|P)/g,r=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let s=a[t];if(r&&(s=s.replace(i,"")),s===u[o.r2.HELM])l.push(n);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";l.push(t)}else l.push(s)}return l.join(s)}convert(t,e){const s=this.getConverter(t,e),n=this.getNewColumn(t,e);return n.init((t=>s(this.column.get(t)))),n}getRegion(t,e,s){const n=this.getNewColumn(this.notation,this.separator);n.name=s,Math.max(...this.splitted.map((t=>t.length)));const i=t??0,r=e??this.maxLength-1,a=this.getJoiner(),l=r-i+1;n.init((t=>{const e=this.splitted[t],s=new Array(l);for(let t=0;t<l;++t){const n=i+t;s[t]=n<e.length?e[n]:u[this.notation]}return a(s)}));const h=t=>{const e=t.split(",").map((t=>t.trim())),s=new Array(l);for(let t=0;t<l;++t){const n=i+t;s[t]=n<e.length?e[n]:"?"}return s.join(o.CI)},c=this.column.getTag(".positionNames");c&&n.setTag(".positionNames",h(c));const m=this.column.getTag(".positionLabels");return m&&n.setTag(".positionLabels",h(m)),n}getJoiner(){const t=this;if(this.notation===o.r2.FASTA)return function(e){return p(t,e)};if(this.notation===o.r2.SEPARATOR)return function(e){return g(t,e,t.separator)};if(this.notation===o.r2.HELM){const e="DNA"===t.alphabet||"RNA"===t.alphabet;return function(s){return f(t,s,e)}}throw new Error}getConverter(t,e=undefined){if(t===o.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const s=this;if(t===o.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?y(t,e):t.getSplitter()(e);return p(t,s)}(s,t)};if(t===o.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA")||e.startsWith("RNA"),n=t.getSplitter()(e);return f(t,n,s)}(s,t)};if(t===o.r2.SEPARATOR)return function(t){return function(t,e,s){const n=t.isHelm()?y(t,e):t.getSplitter()(e);return g(t,n,s)}(s,t,e)};throw new Error}constructor(t){if(this._splitter=null,this._splitted=null,this._stats=null,this._maxLength=null,this._posList=null,t.type!=n.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${n.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(n.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?u[o.r2.FASTA]:this.isHelm()?u[o.r2.HELM]:u[o.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())m.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");m.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(n.TAGS.UNITS)}'.`);m.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return c.uhTemp in t.temp||(t.temp[c.uhTemp]=new m(t)),t.temp[c.uhTemp]}}const d=/[RD]\((\w)\)P?/g;function p(t,e){const s=new Array(e.length);for(const[n,i]of r().enumerate(e)){let r=n;t.isHelm()&&(r=n.replace(d,"$1")),t.isGap(r)?r=u[o.r2.FASTA]:r.length>1&&(r="["+e[i]+"]"),s[i]=r}return s.join("")}function g(t,e,s){const n=new Array(e.length);for(const[s,i]of r().enumerate(e)){let e=s;t.isGap(e)&&(e=u[o.r2.SEPARATOR]),n[i]=e}return n.map((t=>t??"")).join(s)}function f(t,e,s){const[n,i,a,l]=t.getHelmWrappers();return`${n}${r()(e).map((e=>{let n=e;return n=t.isGap(n)?u[o.r2.HELM]:s?n.replace(d,"$1"):1==e.length?`${i}${e}${a}`:`${i}[${e}]${a}`,n})).toArray().join(".")}${l}`}function y(t,e){const s=t.getSplitter()(e),n=new Array(s.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(const[t,e]of r().enumerate(s)){let s=t;(i||o)&&(s=s.replace(d,"$1"),s="P"===s?null:s),n[e]=s}return n.filter((t=>null!==t))}},9298:(t,e,s)=>{"use strict";var n,i,r,o,a,l;s.d(e,{Ct:()=>l,DX:()=>n,ES:()=>i,dE:()=>a,iD:()=>o,vS:()=>h,vw:()=>r}),function(t){t.tooltipWebLogo=".tooltipWebLogo"}(n||(n={})),function(t){t.Entropy="Entropy",t.full="100%"}(i||(i={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(r||(r={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(o||(o={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=i.full,this.positionWidth=16,this.verticalAlignment=r.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},2669:(t,e,s)=>{"use strict";s.d(e,{m:()=>n});class n{constructor(t=!0,e=!0){const n=navigator.hardwareConcurrency;this._workerCount=t?Math.max(n-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(18),s.b)))),this._terminateOnComplete=e}async calc(t,e,s=!0){return new Promise((async(n,i)=>{try{const i=t.length,r=new Array(this._workerCount),o=i*(i-1)/2;this._workerCount=Math.min(this._workerCount,o);const a=o/this._workerCount,l=new Float32Array(o);let h=0,c=1,u=0,m=Number.MIN_VALUE;for(let s=0;s<this._workerCount;s++){const n=Math.floor(s*a),d=s===this._workerCount-1?o:Math.floor((s+1)*a),p=h,g=c;s!==this._workerCount-1&&(h=i-2-Math.floor(Math.sqrt(-8*d+4*i*(i-1)-7)/2-.5),c=d-i*h+Math.floor((h+1)*(h+2)/2)),this._workers[s].postMessage({values:t,fnName:e,startRow:p,startCol:g,chunckSize:d-n}),r[s]=new Promise(((t,e)=>{this._workers[s].onmessage=({data:{error:i,distanceMatrixData:r,min:o,max:a}})=>{this._terminateOnComplete&&this._workers[s].terminate(),i?e(i):(l.set(r,n),o<u&&(u=o),a>m&&(m=a),t())}}))}await Promise.all(r),s&&l.forEach(((t,e)=>{l[e]=(t-u)/(m-u)})),n(l)}catch(t){i(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}},3914:(t,e,s)=>{"use strict";s.d(e,{H:()=>i});var n=s(6814);class i{get data(){return this._data}get size(){return this._size}constructor(t,e){if(null==e){if(null==t)throw new Error("Arguments error: data or size is required.");if(this._data=t,this._size=(1+Math.sqrt(1+8*this._data.length))/2,this._size!=Math.floor(this._size))throw new Error(`Invalid data length ${this._data.length} leads to non integer size ${this._size}`)}else{this._size=e;const s=e*(e-1)/2;if(t){if(t.length!=s)throw new Error(`Invalid data length. Observations size ${e} requires data length ${s}.`);this._data=t}else this._data=new Float32Array(s)}}_linearizeIJ(t,e){if(!(t<e))throw new Error("i must be less than j");return this._size*t+e-Math.floor((t+2)*(t+1)/2)}get(t,e){return t==e?0:t<e?this._data[this._linearizeIJ(t,e)]:this._data[this._linearizeIJ(e,t)]}set(t,e,s){this._data[this._linearizeIJ(t,e)]=s}static calc(t,e){const s=t.length,r=new i(void 0,s);for(let i=0;i<s;i++)for(let o=i+1;o<s;o++)r.set(i,o,(0,n.k)(t[i])||(0,n.k)(t[o])?1:e(t[i],t[o]));return r}square(){for(let t=0;t<this._data.length;t++)this._data[t]=this._data[t]**2}add(t){if(this._size!==t._size)throw new Error(`Matrices must have the same size. This size: ${this._size}, other size: ${t._size}`);for(let e=0;e<this._data.length;e++)this._data[e]+=t._data[e]}sqrt(){for(let t=0;t<this._data.length;t++)this._data[t]=Math.sqrt(this._data[t])}normalize(){let t=0,e=this._data[0];for(let s=0;s<this._data.length;s++)this._data[s]<t&&(t=this._data[s]),this._data[s]>e&&(e=this._data[s]);const s=e-t;for(let n=0;n<this._data.length;n++)this._data[n]=0===s?this._data[n]-t:(this._data[n]-t)/(e-t)}}},6254:(t,e,s)=>{"use strict";function n(t,e){const s=i(e);function n(t,e){const n=Number(t),i=Number(e);return s(n,i)}const r={get:(t,s,i)=>"length"===s?e:new Proxy(t,function(t){return{get:(e,s,i)=>t===s?0:e[Number(t)>Number(s)?n(s,t):n(t,s)]}}(s))};return new Proxy(t,r)}function i(t){return(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2)}s.d(e,{_:()=>n,y:()=>i})},6814:(t,e,s)=>{"use strict";s.d(e,{k:()=>n});const n=t=>null==t},5697:(t,e,s)=>{"use strict";s.d(e,{Dz:()=>g,KR:()=>o,MI:()=>y,NB:()=>u,Om:()=>w,Rt:()=>r,UX:()=>c,WI:()=>h,Zd:()=>l,_h:()=>a,aW:()=>d,bX:()=>v,fX:()=>f,kg:()=>i,s:()=>m,yU:()=>p});var n=s(1040);n.gk.Tanimoto,n.gk.Dice,n.gk.Asymmetric,n.gk.BraunBlanquet,n.gk.Cosine,n.gk.Kulczynski,n.gk.McConnaughey,n.gk.RogotGoldberg,n.gk.Russel,n.gk.Sokal,n.gk.Hamming,n.gk.Euclidean,n.gk.Tanimoto,n.gk.Dice,n.gk.Asymmetric,n.gk.BraunBlanquet,n.gk.Cosine,n.gk.Kulczynski,n.gk.McConnaughey,n.gk.RogotGoldberg,n.gk.Russel,n.gk.Sokal,n.gk.Hamming,n.gk.Euclidean;const i=[n.gk.Tanimoto,n.gk.Dice,n.gk.Cosine],r=[n.gk.Tanimoto,n.gk.Asymmetric,n.gk.Cosine,n.gk.Sokal];function o(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount();if(0==s)return 1;const n=t.andWithCountBits(e,!0);return n/(s-n)}(t,e))}function a(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount();return 0==s?0:2*t.andWithCountBits(e,!0)/s}(t,e))}function l(t,e){return b(function(t,e){const s=t.trueCount()*e.trueCount();return 0==s?0:t.andWithCountBits(e,!0)/Math.sqrt(s)}(t,e))}function h(t,e){return Math.sqrt(t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0))}function c(t,e){return t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0)}function u(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount(),n=t.andWithCountBits(e,!0);return n/(2*s-3*n)}(t,e))}function m(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount(),n=t.trueCount()*e.trueCount();return 0==n?0:t.andWithCountBits(e,!0)*s/(2*n)}(t,e))}function d(t,e){return b(function(t,e){const s=t.trueCount()+e.trueCount(),n=t.trueCount()*e.trueCount();return 0==n?0:(t.andWithCountBits(e,!0)*s-n)/n}(t,e))}function p(t,e){return b(function(t,e){const s=Math.min(t.trueCount(),e.trueCount());return 0==s?0:t.andWithCountBits(e,!0)/s}(t,e))}function g(t,e){return b(function(t,e){const s=Math.max(t.trueCount(),e.trueCount());return 0==s?0:t.andWithCountBits(e,!0)/s}(t,e))}function f(t,e){return b(function(t,e){return 0==t.length?0:t.andWithCountBits(e,!0)/t.length}(t,e))}function y(t,e){return b(function(t,e){const s=t.andWithCountBits(e,!0),n=t.countBits(!0)+e.countBits(!0),i=t.length,r=i-n+s;return s==i||r==i?1:s/n+r/(2*i-n)}(t,e))}function w(t){return 1/(1+t)}function b(t){return 0===t?3402823e32:1/t-1}function v(t,e){return Math.abs(t-e)}},779:(t,e,s)=>{"use strict";function n(){return(t,e)=>{let s=0;t.length!==e.length&&(s=Math.abs(t.length-e.length));let n=0;for(let s=0;s<Math.min(t.length,e.length);s++)t[s]!==e[s]&&n++;return n+=s,n/=Math.max(t.length,e.length),n}}s.d(e,{j:()=>n})},489:(t,e,s)=>{"use strict";s.d(e,{U:()=>n.U,o:()=>n.o});var n=s(5540)},458:(t,e,s)=>{"use strict";s.d(e,{r:()=>i});var n=s(1811);function i(){return(t,e)=>(0,n.T)(t,e)/Math.max(t.length,e.length)}},5540:(t,e,s)=>{"use strict";s.d(e,{U:()=>n,o:()=>a});var n,i=s(779),r=s(458),o=s(6683);!function(t){t.HAMMING="Hamming",t.LEVENSHTEIN="Levenshtein",t.NEEDLEMANN_WUNSCH="Needlemann-Wunsch"}(n||(n={}));const a={[n.HAMMING]:i.j,[n.LEVENSHTEIN]:r.r,[n.NEEDLEMANN_WUNSCH]:o.n}},6683:(t,e,s)=>{"use strict";s.d(e,{n:()=>i});const n={gapOpen:8,gapExtend:2,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};function i(t){return(e,s)=>{const{gapOpen:i,gapExtend:r,scoringMatrix:o,alphabetIndexes:a}={...n,...t},l=[new Array(e.length+1).fill(0),new Array(e.length+1).fill(0)],h=new Array(e.length+1).fill(!1),c=new Array(e.length+1).fill(!1);let u=0,m=1;for(let t=1;t<e.length+1;t++)l[0][t]=-i-(t-1)*r;for(let t=1;t<s.length+1;t++){l[m][0]=-i-(t-1)*r;for(let n=1;n<e.length+1;n++){const d=l[u][n-1]+o[a[e[n-1]]][a[s[t-1]]],p=l[u][n]-(h[n]?r:i),g=l[m][n-1]-(c[n-1]?r:i);l[m][n]=Math.max(d,g,p),l[m][n]===d?(h[n]=!1,c[n]=!1):l[m][n]===g?(h[n]=!1,c[n]=!0):(h[n]=!0,c[n]=!1)}u=m,m=(m+1)%2}const d=e.split("").map((t=>o[a[t]][a[t]])).reduce(((t,e)=>t+e),0),p=s.split("").map((t=>o[a[t]][a[t]])).reduce(((t,e)=>t+e),0),g=Math.max(d,p);return(g-l[u][e.length])/g}}},116:(t,e,s)=>{"use strict";var n;s.d(e,{AL:()=>n,aP:()=>r,bD:()=>i}),s(4221),s(7659),s(3659),s(850),s(9006),s(7861),s(9657),s(2669),s(3914),s(6254),function(t){t.UMAP="UMAP",t.T_SNE="t-SNE"}(n||(n={}));class i{constructor(){this.learningRate={uiName:"Learinig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nComponents={uiName:"Components",value:2,tooltip:"The number of components (dimensions) to project the data to"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, used with spread to control the clumped/dispersed nature of the embedding"}}}class r{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"},this.dim={uiName:"Dimensionality",value:2,tooltip:"Dimensionality of the embedding"}}}},7656:(t,e,s)=>{"use strict";s.d(e,{I:()=>i});var n=s(850);async function i(t,e,i,r,o){const a=await async function(t,e,n,i){return new Promise((function(r,o){const a=new Worker(new URL(s.p+s.u(729),s.b));a.postMessage({columnData:t.data,method:e,measure:t.metric,options:n,parallelDistanceWorkers:i}),a.onmessage=({data:{error:t,distance:e,embedding:s}})=>{t?o(t):r({distance:e,embedding:s}),setTimeout((()=>a.terminate()),0)}}))}({data:t,metric:i},e,r,o);return a.embedding=a.embedding.map((t=>(0,n.Fv)(t))),a}},9006:(t,e,s)=>{"use strict";s.d(e,{Ek:()=>l,a1:()=>a,nR:()=>h});var n=s(850),i=s(4588),r=s(6254),o=s(2669);class a{constructor(t){this.steps=t?.steps??0,this.cycles=t?.cycles??1e6,this.cutoff=t?.cutoff??0,this.lambda=t?.lambda??2,this.dlambda=t?.dlambda??.01,this.lambda2=this.lambda/2,this.dlambda2=this.dlambda/2,this.epsilon=t?.epsilon??1e-10,this.distanceFunction=t?.distance??n.dP,this.distance=new Float32Array,this.distanceFunctionName=t?.distanceFunctionName}async initDistance(t){this.dmIndexFunct=(0,r.y)(t.length);const e=new o.m(!0,!1);this.distance=await e.calc(t,this.distanceFunctionName),e.terminate()}calcDistance(t,e,s){return this.distance[this.dmIndexFunct(e,s)]}async embed(t){const e=t.length,s=(0,n.kO)(e,a.dimension,40);let r=this.lambda2;0===this.steps&&(this.steps=t.length-1),await this.initDistance(t);for(let o=0;o<this.cycles;++o){for(let o=0;o<this.steps;++o){const o=(0,i.I)(e);let a=(0,i.I)(e);for(;o==a;)a=(0,i.I)(e);const l=s[o],h=s[a],c=this.calcDistance(t,o,a),u=(0,n.dP)(l,h);if(0==this.cutoff||c<=this.cutoff||u<c){const t=r*(c-u)/(u+this.epsilon),e=(0,n.On)(l,h,-1);s[o]=(0,n.On)(l,e,t),s[a]=(0,n.On)(h,e,-t)}}if(r-=this.dlambda2,r<=0)break}return s}}a.dimension=2;class l extends a{async embed(t){const e=t.length,s=(0,n.kO)(e,l.dimension,40);let r=this.lambda;await this.initDistance(t);for(let o=0;o<this.cycles;++o){const o=(0,i.I)(e),a=s[o];for(let i=0;i<e;++i){if(o==i)continue;const e=s[i],l=this.calcDistance(t,o,i),h=(0,n.dP)(a,e);if(0==this.cutoff||l<=this.cutoff||h<l){const t=r*(l-h)/(h+this.epsilon),o=(0,n.On)(a,e,-1);s[i]=(0,n.On)(e,o,-t)}}if(r-=this.dlambda,r<=0)break}return s}}class h extends a{constructor(t){super(t),this.cycles=t?.cycles??1e3,this.steps=t?.steps??1e5,this.radiusPercent=t?.radiusPercent??1,this.maxDistance=t?.maxDistance??null,this.maxDistanceSteps=t?.maxDistanceSteps??null}async embed(t){const e=t.length,s=(0,n.kO)(e,h.dimension,40);if(await this.initDistance(t),null===this.maxDistanceSteps&&(this.maxDistanceSteps=e*Math.floor((e-1)/2)),null===this.maxDistance){this.maxDistance=-1e37;for(let s=0;s<this.maxDistanceSteps;s++){const s=(0,i.I)(e);let n=(0,i.I)(e);for(;s==n;)n=(0,i.I)(e);const r=this.calcDistance(t,s,n);r>this.maxDistance&&(this.maxDistance=r)}}let r=this.lambda;const o=0==this.radiusPercent?this.maxDistance:this.maxDistance*this.radiusPercent;for(let a=0;a<this.cycles;++a){for(let a=0;a<this.steps;++a){const a=(0,i.I)(e);let l=(0,i.I)(e);for(;a==l;)l=(0,i.I)(e);const h=s[a],c=s[l],u=this.calcDistance(t,a,l),m=(0,n.dP)(h,c);if(u<=o||m<u){const t=.5*r*(u-m)/(m+this.epsilon),e=(0,n.On)(h,c,-1);s[a]=(0,n.On)(h,e,t),s[l]=(0,n.On)(c,e,-t)}}if(r-=(this.lambda-this.dlambda)/(this.cycles-1),r<this.dlambda)break}return s}}},1040:(t,e,s)=>{"use strict";var n,i,r,o,a;s.d(e,{CF:()=>i,Qe:()=>o,W:()=>n,Yc:()=>a,gk:()=>r}),function(t){t.Levenshtein="Levenshtein",t.JaroWinkler="Jaro-Winkler",t.Manhattan="Manhattan"}(n||(n={})),function(t){t.Euclidean="Euclidean"}(i||(i={})),function(t){t.Tanimoto="Tanimoto",t.Dice="Dice",t.Asymmetric="Asymmetric",t.BraunBlanquet="Braun-Blanquet",t.Cosine="Cosine",t.Kulczynski="Kulczynski",t.McConnaughey="Mc-Connaughey",t.RogotGoldberg="Rogot-Goldberg",t.Russel="Russel",t.Sokal="Sokal",t.Hamming="Hamming",t.Euclidean="Euclidean"}(r||(r={})),function(t){t.Vector="Vector",t.String="String",t.BitArray="BitArray",t.MacroMolecule="MacroMolecule",t.Number="Number"}(o||(o={})),function(t){t.NumericDistance="NumericDistance"}(a||(a={}))},7861:(t,e,s)=>{"use strict";var n=s(1811),i=s(3979),r=s(5697),o=s(850),a=s(489),l=s(1040);const h={[l.CF.Euclidean]:o.dP},c={[l.W.Levenshtein]:n.T,[l.W.JaroWinkler]:i.H$,[l.W.Manhattan]:function(t,e){if(t.length!==e.length)return 1;{let s=0;for(let n=1;n<t.length;n++)s+=t[n]==e[n]?0:1;return s/t.length}}},u={[l.gk.Tanimoto]:r.KR,[l.gk.Dice]:r._h,[l.gk.Asymmetric]:r.yU,[l.gk.BraunBlanquet]:r.Dz,[l.gk.Cosine]:r.Zd,[l.gk.Kulczynski]:r.s,[l.gk.McConnaughey]:r.aW,[l.gk.RogotGoldberg]:r.MI,[l.gk.Russel]:r.fX,[l.gk.Sokal]:r.NB,[l.gk.Hamming]:r.UX,[l.gk.Euclidean]:r.WI},m={[l.Yc.NumericDistance]:r.bX},d={[l.Qe.Vector]:{[l.CF.Euclidean]:h[l.CF.Euclidean]},[l.Qe.String]:{[l.W.Levenshtein]:c[l.W.Levenshtein],[l.W.JaroWinkler]:c[l.W.JaroWinkler],[l.W.Manhattan]:c[l.W.Manhattan]},[l.Qe.BitArray]:{[l.gk.Tanimoto]:u[l.gk.Tanimoto],[l.gk.Dice]:u[l.gk.Dice],[l.gk.Asymmetric]:u[l.gk.Asymmetric],[l.gk.BraunBlanquet]:u[l.gk.BraunBlanquet],[l.gk.Cosine]:u[l.gk.Cosine],[l.gk.Kulczynski]:u[l.gk.Kulczynski],[l.gk.McConnaughey]:u[l.gk.McConnaughey],[l.gk.RogotGoldberg]:u[l.gk.RogotGoldberg],[l.gk.Russel]:u[l.gk.Russel],[l.gk.Sokal]:u[l.gk.Sokal]},[l.Qe.MacroMolecule]:{[a.U.HAMMING]:a.o[a.U.HAMMING],[a.U.LEVENSHTEIN]:a.o[a.U.LEVENSHTEIN],[a.U.NEEDLEMANN_WUNSCH]:a.o[a.U.NEEDLEMANN_WUNSCH]},[l.Qe.Number]:{[l.Yc.NumericDistance]:m[l.Yc.NumericDistance]}};Object.keys(d).reduce(((t,e)=>{for(const s of Object.keys(d[e]))t[s]=e;return t}),{})},9657:(t,e,s)=>{"use strict";class n{constructor(t,e=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof t){const s=t,i=n._createBuffer(s);if(e)for(let t=0;t<i.length;t++)i[t]=-1;this._data=i,this._length=s}else{if(!(t instanceof Uint32Array))throw new Error("Invalid constructor");this._data=t,this._length=e}}getRawData(){return this._data}assureGoez(t,e){if(t<0)throw new Error(`${e} should be greater than zero`)}assureInRange(t,e,s,n){if(t<e||t>s)throw new Error(`Argument ${n} (${t}) out of range (${e}, ${s})`)}copy(t,e,s){for(let n=0;n<s;n++)e[n]=t[n]}copyFrom(t){if(this._length!=t._length)throw new Error(`Lengths differ (${this._length} != ${t._length})`);this.copy(t._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(t){this._data=t,this._version++}get version(){return this._version}set version(t){this._version=t}incrementVersion(t=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(t){this._versionedName=t,this._versionedNameVersion=this._version}get self(){return this}setLength(t){if(t<0)throw new Error("should be >= 0");if(t==this._length)return;const e=Math.floor((t+31)/32);if(e>this._data.length||e+this.SHRINK_THRESHOLD<this._data.length){const t=new Uint32Array(e);this.copy(this._data,t,e>this._data.length?this._data.length:e),this._data=t}t>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,e)),this._length=t,this._version++}static fromAnd(t,e){if(t._length!=e._length)throw new Error(`Lengths differ (${t._length} != ${e._length})`);const s=new n(t._length);s._length=t._length,s._data=n._createBuffer(s._length),s._version=0;const i=t.lengthInInts;for(let n=0;n<i;n++)s._data[n]=t._data[n]&e._data[n];return s}static _createBuffer(t){return new Uint32Array(Math.floor((t+31)/32))}static fromValues(t){const e=new n(t.length);e._version=0;for(let s=0;s<e._length;s++)t[s]&&(e._data[Math.floor(s/32)]|=1<<(s%32&31));return e}static fromSeq(t,e){const s=new n(t);for(let n=0;n<t;++n)s.setBit(n,e(n));return s._version=0,s}static fromString(t){return n.fromSeq(t.length,(e=>"1"==t.charAt(e)))}static fromUint32Array(t,e){const s=new n(t);return s._data=e,s}static fromBytes(t){const e=t.length,s=new n(8*e);s._data=new Uint32Array(Math.floor((e+3)/4)),s._length=8*e;let i=0,r=0;for(;e-r>=4;)s._data[i++]=255&t[r]|(255&t[r+1])<<8|(255&t[r+2])<<16|(255&t[r+3])<<24,r+=4;return e-r==3&&(s._data[i]=(255&t[r+2])<<16),e-r==2&&(s._data[i]|=(255&t[r+1])<<8),e-r==1&&(s._data[i]|=255&t[r]),s._version=0,s}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(t){if(this==t)return!0;if(null==t)return!1;if(this._length!=t._length)return!1;if(0==this._length)return!0;for(let e=0;e<this._data.length-1;e++)if(this._data[e]!=t._data[e])return!1;for(let e=8*(this._data.length-1);e<this._length;e++)if(this.getBit(e)!=t.getBit(e))return!1;return!0}clone(){const t=new n(0,!1);return t._data=Uint32Array.from(this._data),t._length=this._length,t._version=this._version,t}init(t,e){this.setAll(!1,!1);for(let e=0;e<this._length;e++)t(e)&&(this._data[Math.floor(e/32)]|=1<<(e%32&31));return this.incrementVersion(e),this}invert(t=!0){for(let t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const s=t?-1:0,n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]=s;this.incrementVersion(e)}setIndexes(t,e=!0,s=!0,n=!0){s&&this.setAll(!e,!1);for(const s of t)this.setFast(s,e);this.incrementVersion(n)}everyIndex(t,e=!0){for(const s of t)if(this.getBit(s)!=e)return!1;return!0}anyIndex(t,e=!0){for(const s of t)if(this.getBit(s)==e)return!0;return!1}setWhere(t,e=!0,s=!0,n=!0,i=!0){if(s&&i&&this.setAll(!e,!1),i)for(let s=0;s<this._length;s++)t(s)&&this.setFast(s,e);else for(let s=0;s<this._length;s++)this.setFast(s,t(s)?e:!e);this.incrementVersion(n)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const s=[];for(let n=t;n<e;++n)s.push(this.getBit(n));return n.fromValues(s)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const s=[];for(let n=t;n<e;++n)s.push(this.getBit(n));return s}setRange(t,e,s,n=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const i=Math.min(t,e),r=Math.max(t,e);if(s)for(let t=i;t<=r;t++)this.setTrue(t);else for(let t=i;t<=r;t++)this.setFalse(t);return this.incrementVersion(n),this}setRandom(t,e,s=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let s=0;s<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),s++)}this.incrementVersion(s)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const s=this.lengthInInts;for(let e=0;e<s;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]|=t._data[e];return this.incrementVersion(e),this}xor(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,s=this.lengthInInts;e<s;e++)this._data[e]^=t._data[e];return this.incrementVersion(e),this}insertAt(t,e,s=!1){if(this.assureInRange(t,0,this._length,"pos"),0==e)return;const n=this._length;this.setLength(this._length+e);for(let s=n-1;s>=t;s--)this.setBit(s+e,this.getBit(s));for(let n=t;n<t+e;n++)this.setBit(n,s)}removeAt(t,e=1){if(e<0)throw new Error("n cannot be negative");if(this.assureInRange(t,0,this._length-e,"pos"),this.contains(!0))for(let s=t;s<this._length-e;s++)this.setBit(s,this.getBit(s+e));this.setLength(this._length-e)}removeByMask(t,e=!0){if(this._length!=t.length)throw new Error("length != mask.length");if(t==this)this.setLength(t.countBits(!e)),this.setAll(!e);else{let s=0;for(let n=-1;-1!=(n=t.findNext(n,!e));)this.setFast(s++,this.getBit(n));this._length=s,this._version++}return this}getBit(t){return 0!=(this._data[Math.floor(t/32)]&1<<(31&t))}setBit(t,e,s=!0){this.setFast(t,e),this._version++}setFast(t,e){e?this._data[Math.floor(t/32)]|=1<<(31&t):this._data[Math.floor(t/32)]&=~(1<<(31&t))}setTrue(t){this._data[Math.floor(t/32)]|=1<<(31&t)}setFalse(t){this._data[Math.floor(t/32)]&=~(1<<(31&t))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(t){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const t=this.lengthInInts;let e=0;for(;e<t-1;e++)for(let t=this._data[e];0!=t;t>>>=8)this._selectedCount+=n._onBitCount[255&t];let s=this._data[e];const i=31&this._length;for(0!=i&&(s&=~(4294967295<<i));0!=s;s>>>=8)this._selectedCount+=n._onBitCount[255&s];this._selectedCountVersion=this._version}return t?this._selectedCount:this._length-this._selectedCount}countWhere(t){let e=0;if(this.trueCount()==this._length)for(let s=0;s<this._length;s++)e+=t(s)?1:0;else for(let s=-1;-1!=(s=this.findNext(s,!0));)e+=t(s)?1:0;return e}andWithCountBits(t,e){if(0==this._length)return 0;let s=0;const i=this.lengthInInts;let r=0;for(;r<i-1;r++)for(let e=this._data[r]&t._data[r];0!=e;e>>>=8)s+=n._onBitCount[255&e];let o=this._data[r]&t._data[r];const a=31&this._length;for(0!=a&&(o&=~(4294967295<<a));0!=o;o>>>=8)s+=n._onBitCount[255&o];return e?s:this._length-s}clear(){this.setLength(0)}contains(t){return this.findNext(-1,t)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(t,e=!0){if(this.assureInRange(t,-1,this._length,"index"),t>=this._length-1)return-1;let s=31&(t=t<0?0:t+1);const i=this.lengthInInts;for(let r=Math.floor(t/32);r<i;r++){let i=e?this._data[r]:~this._data[r];if(0!=s)i&=4294967295<<s&4294967295,s=0;else if(!e&&-4294967296==i)continue;for(let e=0;0!=i;e+=8,i>>>=8){const s=n._firstOnBit[255&i];if(s>=0)return(t=s+32*r+e)>=this._length?-1:t}}return-1}findPrev(t,e=!0){if(0==t)return-1;this.assureInRange(t,-1,this._length,"index");let s=1+(t=t<0?this._length-1:t-1)&31;for(let i=Math.floor(t/32);i>=0;i--){let t=e?this._data[i]:~this._data[i];0!=s&&(t&=~(4294967295<<s),s=0);for(let e=24;0!=t;e-=8,t<<=8){const s=n._lastOnBit[t>>>24];if(s>=0)return s+32*i+e}}return-1}}n._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),n._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),n._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},4588:(t,e,s)=>{"use strict";function n(t){return Math.random()*t}function i(t){return Math.floor(n(t))}s.d(e,{I:()=>i,t:()=>n})},8518:(t,e,s)=>{"use strict";s.d(e,{L:()=>i});var n=s(4588);function i(t,e,s){function i(t,e){let s=null,n=null;for(const i of t){const t=e(i);(null==n||t>n)&&(s=i,n=t)}return s}const r=[(0,n.I)(t-1)],o=new Set;for(let e=0;e<t;++e)r.includes(e)||o.add(e);for(;r.length<e;){const t=i(o.values(),(t=>Math.min.apply(Math,r.map((function(e,n){return s(t,e)})))));null!=t&&(r.push(t),o.delete(t))}return r}},1061:(t,e,s)=>{"use strict";s.d(e,{gw:()=>r}),s(4469),s(976);var n,i=function(t,e,s,n){return new(s||(s=Promise))((function(i,r){function o(t){try{l(n.next(t))}catch(t){r(t)}}function a(t){try{l(n.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?i(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((n=n.apply(t,e||[])).next())}))};function r(t){return i(this,void 0,void 0,(function*(){yield new Promise((e=>setTimeout(e,t)))}))}!function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(n||(n={}))},3659:(t,e,s)=>{"use strict";s.d(e,{OW:()=>n});class n extends Float32Array{}},850:(t,e,s)=>{"use strict";s.d(e,{Fv:()=>h,On:()=>o,dP:()=>l,hu:()=>r,kO:()=>a});var n=s(3659),i=s(4588);function r(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function o(t,e,s=1){const i=t.length;r(i==e.length,"Vector lengths do not match.");const o=new n.OW(i);for(let n=0;n<t.length;++n)o[n]=t[n]+s*e[n];return o}function a(t,e,s=1){const r=function(t,e,s=0){return new Array(t).fill(s).map((()=>new n.OW(e).fill(s)))}(t,e);for(let n=0;n<t;++n)for(let t=0;t<e;++t)r[n][t]=(0,i.t)(s);return r}function l(t,e){const s=function(t){let e=0;for(let s=0;s<t.length;++s)e+=t[s];return e}(function(t){const e=t.length,s=new n.OW(e);for(let e=0;e<t.length;++e)s[e]=t[e]*t[e];return s}(o(t,e,-1)));return Math.sqrt(s)}function h(t){let e=0,s=0;for(let s=0;s<t.length;++s)e+=t[s];e/=t.length;for(let n=0;n<t.length;++n)s+=(t[n]-e)*(t[n]-e);s=Math.sqrt(s/t.length);for(let n=0;n<t.length;++n)t[n]=(t[n]-e)/s;return t}},7659:(t,e,s)=>{"use strict";e.Z=void 0;var n=s(6215);Object.defineProperty(e,"Z",{enumerable:!0,get:function(){return n.TSNE}})},6215:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.TSNE=void 0,e.TSNE=class{constructor(t){this.returnV=!1,this.vValue=0,this.iter=0,t=t||{},this.perplexity=this.getopt(t,"perplexity",30),this.dim=this.getopt(t,"dim",2),this.epsilon=this.getopt(t,"epsilon",10)}assert(t,e){if(!t)throw e||"Assertion failed"}getopt(t,e,s){return t.hasOwnProperty(e)?t[e]:s}gaussRandom(){if(this.returnV)return this.returnV=!1,this.vValue;const t=2*Math.random()-1,e=2*Math.random()-1,s=t*t+e*e;if(0===s||s>1)return this.gaussRandom();const n=Math.sqrt(-2*Math.log(s)/s);return this.vValue=e*n,this.returnV=!0,t*n}randn(t,e){return t+this.gaussRandom()*e}zeros(t){if(void 0===t||isNaN(t))return[];if("undefined"==typeof ArrayBuffer){const e=new Array(t);for(let s=0;s<t;s++)e[s]=0;return e}return new Float64Array(t)}randn2d(t,e,s){const n=void 0!==s,i=[];for(let r=0;r<t;r++){const t=[];for(let i=0;i<e;i++)n?t.push(s):t.push(this.randn(0,1e-4));i.push(t)}return i}L2(t,e){const s=t.length;let n=0;for(let i=0;i<s;i++){const s=t[i],r=e[i];n+=(s-r)*(s-r)}return n}xtod(t){const e=t.length,s=this.zeros(e*e);for(let n=0;n<e;n++)for(let i=n+1;i<e;i++){const r=this.L2(t[n],t[i]);s[n*e+i]=r,s[i*e+n]=r}return s}d2p(t,e,s){const n=Math.sqrt(t.length),i=Math.floor(n);this.assert(i===n,"D should have square number of elements.");const r=Math.log(e),o=this.zeros(i*i),a=this.zeros(i);for(let e=0;e<i;e++){let n=-1/0,l=1/0,h=1,c=!1;const u=50;let m=0;for(;!c;){let o=0;for(let s=0;s<i;s++){let n=Math.exp(-t[e*i+s]*h);e===s&&(n=0),a[s]=n,o+=n}let d=0;for(let t=0;t<i;t++){let e;e=0===o?0:a[t]/o,a[t]=e,e>1e-7&&(d-=e*Math.log(e))}d>r?(n=h,l===1/0?h*=2:h=(h+l)/2):(l=h,n===-1/0?h/=2:h=(h+n)/2),m++,Math.abs(d-r)<s&&(c=!0),m>=u&&(c=!0)}for(let t=0;t<i;t++)o[e*i+t]=a[t]}const l=this.zeros(i*i),h=2*i;for(let t=0;t<i;t++)for(let e=0;e<i;e++)l[t*i+e]=Math.max((o[t*i+e]+o[e*i+t])/h,1e-100);return l}sign(t){return t>0?1:t<0?-1:0}initDataRaw(t){const e=t.length,s=t[0].length;this.assert(e>0," X is empty? You must have some data!"),this.assert(s>0," X[0] is empty? Where is the data?");const n=this.xtod(t);this.P=this.d2p(n,this.perplexity,1e-4),this.N=e,this.initSolution()}initDataDist(t){const e=t.length;this.assert(e>0," X is empty? You must have some data!");const s=this.zeros(e*e);for(let n=0;n<e;n++)for(let i=n+1;i<e;i++){const r=t[n][i];s[n*e+i]=r,s[i*e+n]=r}this.P=this.d2p(s,this.perplexity,1e-4),this.N=e,this.initSolution()}initSolution(){this.Y=this.randn2d(this.N,this.dim),this.gains=this.randn2d(this.N,this.dim,1),this.ystep=this.randn2d(this.N,this.dim,0),this.iter=0}getSolution(){return this.Y}step(){this.iter+=1;const t=this.N,e=this.costGrad(this.Y),s=e.cost,n=e.grad,i=this.zeros(this.dim);for(let e=0;e<t;e++)for(let t=0;t<this.dim;t++){const s=n[e][t],r=this.ystep[e][t],o=this.gains[e][t];let a=this.sign(s)===this.sign(r)?.8*o:o+.2;a<.01&&(a=.01),this.gains[e][t]=a;const l=(this.iter<250?.5:.8)*r-this.epsilon*a*n[e][t];this.ystep[e][t]=l,this.Y[e][t]+=l,i[t]+=this.Y[e][t]}for(let e=0;e<t;e++)for(let s=0;s<this.dim;s++)this.Y[e][s]-=i[s]/t;return s}debugGrad(){const t=this.N,e=this.costGrad(this.Y),s=(e.cost,e.grad),n=1e-5;for(let e=0;e<t;e++)for(let t=0;t<this.dim;t++){const i=this.Y[e][t];this.Y[e][t]=i+n;const r=this.costGrad(this.Y);this.Y[e][t]=i-n;const o=this.costGrad(this.Y),a=s[e][t],l=(r.cost-o.cost)/(2*n);console.log(e+","+t+": gradcheck analytic: "+a+" vs. numerical: "+l),this.Y[e][t]=i}}costGrad(t){const e=this.N,s=this.dim,n=this.P,i=this.iter<100?4:1,r=this.zeros(e*e);let o=0;for(let n=0;n<e;n++)for(let i=n+1;i<e;i++){let a=0;for(let e=0;e<s;e++){const s=t[n][e]-t[i][e];a+=s*s}const l=1/(1+a);r[n*e+i]=l,r[i*e+n]=l,o+=2*l}const a=e*e,l=this.zeros(a);for(let t=0;t<a;t++)l[t]=Math.max(r[t]/o,1e-100);let h=0;const c=[];for(let o=0;o<e;o++){const a=new Array(s);for(let t=0;t<s;t++)a[t]=0;for(let c=0;c<e;c++){h+=-n[o*e+c]*Math.log(l[o*e+c]);const u=4*(i*n[o*e+c]-l[o*e+c])*r[o*e+c];for(let e=0;e<s;e++)a[e]+=u*(t[o][e]-t[c][e])}c.push(a)}return{cost:h,grad:c}}}},5362:(t,e,s)=>{"use strict";s.d(e,{Z:()=>a});var n=s(7537),i=s.n(n),r=s(3645),o=s.n(r)()(i());o.push([t.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=o},9564:(t,e,s)=>{"use strict";s.d(e,{Z:()=>a});var n=s(7537),i=s.n(n),r=s(3645),o=s.n(r)()(i());o.push([t.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=o},9414:(t,e,s)=>{"use strict";s.d(e,{Z:()=>a});var n=s(7537),i=s.n(n),r=s(3645),o=s.n(r)()(i());o.push([t.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n"],sourceRoot:""}]);const a=o},3645:t=>{"use strict";t.exports=function(t){var e=[];return e.toString=function(){return this.map((function(e){var s="",n=void 0!==e[5];return e[4]&&(s+="@supports (".concat(e[4],") {")),e[2]&&(s+="@media ".concat(e[2]," {")),n&&(s+="@layer".concat(e[5].length>0?" ".concat(e[5]):""," {")),s+=t(e),n&&(s+="}"),e[2]&&(s+="}"),e[4]&&(s+="}"),s})).join("")},e.i=function(t,s,n,i,r){"string"==typeof t&&(t=[[null,t,void 0]]);var o={};if(n)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(o[l]=!0)}for(var h=0;h<t.length;h++){var c=[].concat(t[h]);n&&o[c[0]]||(void 0!==r&&(void 0===c[5]||(c[1]="@layer".concat(c[5].length>0?" ".concat(c[5]):""," {").concat(c[1],"}")),c[5]=r),s&&(c[2]?(c[1]="@media ".concat(c[2]," {").concat(c[1],"}"),c[2]=s):c[2]=s),i&&(c[4]?(c[1]="@supports (".concat(c[4],") {").concat(c[1],"}"),c[4]=i):c[4]="".concat(i)),e.push(c))}},e}},7537:t=>{"use strict";t.exports=function(t){var e=t[1],s=t[3];if(!s)return e;if("function"==typeof btoa){var n=btoa(unescape(encodeURIComponent(JSON.stringify(s)))),i="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(n),r="/*# ".concat(i," */");return[e].concat([r]).join("\n")}return[e].join("\n")}},9133:function(t,e,s){var n;!function(e,i){var r={};!function(t){"use strict";t.__esModule=!0,t.digestLength=32,t.blockSize=64;var e=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function s(t,s,n,i,r){for(var o,a,l,h,c,u,m,d,p,g,f,y,w;r>=64;){for(o=s[0],a=s[1],l=s[2],h=s[3],c=s[4],u=s[5],m=s[6],d=s[7],g=0;g<16;g++)f=i+4*g,t[g]=(255&n[f])<<24|(255&n[f+1])<<16|(255&n[f+2])<<8|255&n[f+3];for(g=16;g<64;g++)y=((p=t[g-2])>>>17|p<<15)^(p>>>19|p<<13)^p>>>10,w=((p=t[g-15])>>>7|p<<25)^(p>>>18|p<<14)^p>>>3,t[g]=(y+t[g-7]|0)+(w+t[g-16]|0);for(g=0;g<64;g++)y=(((c>>>6|c<<26)^(c>>>11|c<<21)^(c>>>25|c<<7))+(c&u^~c&m)|0)+(d+(e[g]+t[g]|0)|0)|0,w=((o>>>2|o<<30)^(o>>>13|o<<19)^(o>>>22|o<<10))+(o&a^o&l^a&l)|0,d=m,m=u,u=c,c=h+y|0,h=l,l=a,a=o,o=y+w|0;s[0]+=o,s[1]+=a,s[2]+=l,s[3]+=h,s[4]+=c,s[5]+=u,s[6]+=m,s[7]+=d,i+=64,r-=64}return i}var n=function(){function e(){this.digestLength=t.digestLength,this.blockSize=t.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return e.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},e.prototype.clean=function(){for(var t=0;t<this.buffer.length;t++)this.buffer[t]=0;for(t=0;t<this.temp.length;t++)this.temp[t]=0;this.reset()},e.prototype.update=function(t,e){if(void 0===e&&(e=t.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var n=0;if(this.bytesHashed+=e,this.bufferLength>0){for(;this.bufferLength<64&&e>0;)this.buffer[this.bufferLength++]=t[n++],e--;64===this.bufferLength&&(s(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(e>=64&&(n=s(this.temp,this.state,t,n,e),e%=64);e>0;)this.buffer[this.bufferLength++]=t[n++],e--;return this},e.prototype.finish=function(t){if(!this.finished){var e=this.bytesHashed,n=this.bufferLength,i=e/536870912|0,r=e<<3,o=e%64<56?64:128;this.buffer[n]=128;for(var a=n+1;a<o-8;a++)this.buffer[a]=0;this.buffer[o-8]=i>>>24&255,this.buffer[o-7]=i>>>16&255,this.buffer[o-6]=i>>>8&255,this.buffer[o-5]=i>>>0&255,this.buffer[o-4]=r>>>24&255,this.buffer[o-3]=r>>>16&255,this.buffer[o-2]=r>>>8&255,this.buffer[o-1]=r>>>0&255,s(this.temp,this.state,this.buffer,0,o),this.finished=!0}for(a=0;a<8;a++)t[4*a+0]=this.state[a]>>>24&255,t[4*a+1]=this.state[a]>>>16&255,t[4*a+2]=this.state[a]>>>8&255,t[4*a+3]=this.state[a]>>>0&255;return this},e.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},e.prototype._saveState=function(t){for(var e=0;e<this.state.length;e++)t[e]=this.state[e]},e.prototype._restoreState=function(t,e){for(var s=0;s<this.state.length;s++)this.state[s]=t[s];this.bytesHashed=e,this.finished=!1,this.bufferLength=0},e}();t.Hash=n;var i=function(){function t(t){this.inner=new n,this.outer=new n,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var e=new Uint8Array(this.blockSize);if(t.length>this.blockSize)(new n).update(t).finish(e).clean();else for(var s=0;s<t.length;s++)e[s]=t[s];for(s=0;s<e.length;s++)e[s]^=54;for(this.inner.update(e),s=0;s<e.length;s++)e[s]^=106;for(this.outer.update(e),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),s=0;s<e.length;s++)e[s]=0}return t.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},t.prototype.clean=function(){for(var t=0;t<this.istate.length;t++)this.ostate[t]=this.istate[t]=0;this.inner.clean(),this.outer.clean()},t.prototype.update=function(t){return this.inner.update(t),this},t.prototype.finish=function(t){return this.outer.finished?this.outer.finish(t):(this.inner.finish(t),this.outer.update(t,this.digestLength).finish(t)),this},t.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},t}();function r(t){var e=(new n).update(t),s=e.digest();return e.clean(),s}function o(t,e){var s=new i(t).update(e),n=s.digest();return s.clean(),n}function a(t,e,s,n){var i=n[0];if(0===i)throw new Error("hkdf: cannot expand more");e.reset(),i>1&&e.update(t),s&&e.update(s),e.update(n),e.finish(t),n[0]++}t.HMAC=i,t.hash=r,t.default=r,t.hmac=o;var l=new Uint8Array(t.digestLength);t.hkdf=function(t,e,s,n){void 0===e&&(e=l),void 0===n&&(n=32);for(var r=new Uint8Array([1]),h=o(e,t),c=new i(h),u=new Uint8Array(c.digestLength),m=u.length,d=new Uint8Array(n),p=0;p<n;p++)m===u.length&&(a(u,c,s,r),m=0),d[p]=u[m++];return c.clean(),u.fill(0),r.fill(0),d},t.pbkdf2=function(t,e,s,n){for(var r=new i(t),o=r.digestLength,a=new Uint8Array(4),l=new Uint8Array(o),h=new Uint8Array(o),c=new Uint8Array(n),u=0;u*o<n;u++){var m=u+1;a[0]=m>>>24&255,a[1]=m>>>16&255,a[2]=m>>>8&255,a[3]=m>>>0&255,r.reset(),r.update(e),r.update(a),r.finish(h);for(var d=0;d<o;d++)l[d]=h[d];for(d=2;d<=s;d++){r.reset(),r.update(h).finish(h);for(var p=0;p<o;p++)l[p]^=h[p]}for(d=0;d<o&&u*o+d<n;d++)c[u*o+d]=l[d]}for(u=0;u<o;u++)l[u]=h[u]=0;for(u=0;u<4;u++)a[u]=0;return r.clean(),c}}(r);var o=r.default;for(var a in r)o[a]=r[a];"object"==typeof t.exports?t.exports=o:void 0===(n=function(){return o}.call(r,s,r,t))||(t.exports=n)}()},1811:(t,e,s)=>{"use strict";s.d(e,{T:()=>i});const n=new Uint32Array(65536),i=(t,e)=>{if(t.length<e.length){const s=e;e=t,t=s}return 0===e.length?t.length:t.length<=32?((t,e)=>{const s=t.length,i=e.length,r=1<<s-1;let o=-1,a=0,l=s,h=s;for(;h--;)n[t.charCodeAt(h)]|=1<<h;for(h=0;h<i;h++){let t=n[e.charCodeAt(h)];const s=t|a;t|=(t&o)+o^o,a|=~(t|o),o&=t,a&r&&l++,o&r&&l--,a=a<<1|1,o=o<<1|~(s|a),a&=s}for(h=s;h--;)n[t.charCodeAt(h)]=0;return l})(t,e):((t,e)=>{const s=e.length,i=t.length,r=[],o=[],a=Math.ceil(s/32),l=Math.ceil(i/32);for(let t=0;t<a;t++)o[t]=-1,r[t]=0;let h=0;for(;h<l-1;h++){let a=0,l=-1;const c=32*h,u=Math.min(32,i)+c;for(let e=c;e<u;e++)n[t.charCodeAt(e)]|=1<<e;for(let t=0;t<s;t++){const s=n[e.charCodeAt(t)],i=o[t/32|0]>>>t&1,h=r[t/32|0]>>>t&1,c=s|a,u=((s|h)&l)+l^l|s|h;let m=a|~(u|l),d=l&u;m>>>31^i&&(o[t/32|0]^=1<<t),d>>>31^h&&(r[t/32|0]^=1<<t),m=m<<1|i,d=d<<1|h,l=d|~(c|m),a=m&c}for(let e=c;e<u;e++)n[t.charCodeAt(e)]=0}let c=0,u=-1;const m=32*h,d=Math.min(32,i-m)+m;for(let e=m;e<d;e++)n[t.charCodeAt(e)]|=1<<e;let p=i;for(let t=0;t<s;t++){const s=n[e.charCodeAt(t)],a=o[t/32|0]>>>t&1,l=r[t/32|0]>>>t&1,h=s|c,m=((s|l)&u)+u^u|s|l;let d=c|~(m|u),g=u&m;p+=d>>>i-1&1,p-=g>>>i-1&1,d>>>31^a&&(o[t/32|0]^=1<<t),g>>>31^l&&(r[t/32|0]^=1<<t),d=d<<1|a,g=g<<1|l,u=g|~(h|d),c=d&h}for(let e=m;e<d;e++)n[t.charCodeAt(e)]=0;return p})(t,e)}},3979:(t,e)=>{"use strict";e.H$=void 0,e.H$=function(t,e,s){var n=function(t,e,s){if(0===t.length||0===e.length)return 0;if(s&&!s.caseSensitive&&(t=t.toUpperCase(),e=e.toUpperCase()),t===e)return 1;for(var n=0,i=t.length,r=e.length,o=Math.floor(Math.max(i,r)/2)-1,a=new Array(i),l=new Array(r),h=0;h<i;h++)for(var c=Math.max(0,h-o);c<=Math.min(r,h+o+1);c++)if(!a[h]&&!l[c]&&t[h]===e[c]){++n,a[h]=l[c]=!0;break}if(0===n)return 0;var u=0,m=0;for(h=0;h<i;h++)if(a[h]){for(;!l[m];)m++;t.charAt(h)!==e.charAt(m++)&&u++}return(n/i+n/r+(n-(u/=2))/n)/3}(t,e,s),i=0;if(n>.7){for(var r=Math.min(t.length,e.length),o=0;t[o]===e[o]&&o<4&&o<r;)++i,o++;n+=.1*i*(1-n)}return n}},9251:(t,e,s)=>{"use strict";s.r(e),s.d(e,{default:()=>P});const n=Object.prototype.toString;function i(t){return n.call(t).endsWith("Array]")}function r(t,e,s){let n=0;const i=s(e);for(let e=0;e<t.x.length;e++)n+=Math.abs(t.y[e]-i(t.x[e]));return n}const o=Object.prototype.toString;function a(t){return o.call(t).endsWith("Array]")}const l=Object.prototype.toString;function h(t){return l.call(t).endsWith("Array]")}const c=Object.prototype.toString;const u=Object.prototype.toString;function m(t){var e,s=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!h(t))throw new TypeError("input must be an array");if(0===t.length)throw new TypeError("input must not be empty");if(void 0!==s.output){if(!h(s.output))throw new TypeError("output option must be an array if specified");e=s.output}else e=new Array(t.length);var n=function(t){var e,s=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(e=t,!u.call(e).endsWith("Array]"))throw new TypeError("input must be an array");if(0===t.length)throw new TypeError("input must not be empty");var n=s.fromIndex,i=void 0===n?0:n,r=s.toIndex,o=void 0===r?t.length:r;if(i<0||i>=t.length||!Number.isInteger(i))throw new Error("fromIndex must be a positive integer smaller than length");if(o<=i||o>t.length||!Number.isInteger(o))throw new Error("toIndex must be an integer greater than fromIndex and at most equal to length");for(var a=t[i],l=i+1;l<o;l++)t[l]<a&&(a=t[l]);return a}(t),i=function(t){var e,s=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(e=t,!c.call(e).endsWith("Array]"))throw new TypeError("input must be an array");if(0===t.length)throw new TypeError("input must not be empty");var n=s.fromIndex,i=void 0===n?0:n,r=s.toIndex,o=void 0===r?t.length:r;if(i<0||i>=t.length||!Number.isInteger(i))throw new Error("fromIndex must be a positive integer smaller than length");if(o<=i||o>t.length||!Number.isInteger(o))throw new Error("toIndex must be an integer greater than fromIndex and at most equal to length");for(var a=t[i],l=i+1;l<o;l++)t[l]>a&&(a=t[l]);return a}(t);if(n===i)throw new RangeError("minimum and maximum input values are equal. Cannot rescale a constant array");var r=s.min,o=void 0===r?s.autoMinMax?n:0:r,a=s.max,l=void 0===a?s.autoMinMax?i:1:a;if(o>=l)throw new RangeError("min option must be smaller than max option");for(var m=(l-o)/(i-n),d=0;d<t.length;d++)e[d]=(t[d]-n)*m+o;return e}const d=" ".repeat(2),p=" ".repeat(4);function g(t,e={}){const{maxRows:s=15,maxColumns:n=10,maxNumSize:i=8,padMinus:r="auto"}=e;return`${t.constructor.name} {\n${d}[\n${p}${function(t,e,s,n,i){const{rows:r,columns:o}=t,a=Math.min(r,e),l=Math.min(o,s),h=[];if("auto"===i){i=!1;t:for(let e=0;e<a;e++)for(let s=0;s<l;s++)if(t.get(e,s)<0){i=!0;break t}}for(let e=0;e<a;e++){let s=[];for(let r=0;r<l;r++)s.push(f(t.get(e,r),n,i));h.push(`${s.join(" ")}`)}return l!==o&&(h[h.length-1]+=` ... ${o-s} more columns`),a!==r&&h.push(`... ${r-e} more rows`),h.join(`\n${p}`)}(t,s,n,i,r)}\n${d}]\n${d}rows: ${t.rows}\n${d}columns: ${t.columns}\n}`}function f(t,e,s){return(t>=0&&s?` ${y(t,e-1)}`:y(t,e)).padEnd(e)}function y(t,e){let s=t.toString();if(s.length<=e)return s;let n=t.toFixed(e);if(n.length>e&&(n=t.toFixed(Math.max(0,e-(n.length-e)))),n.length<=e&&!n.startsWith("0.000")&&!n.startsWith("-0.000"))return n;let i=t.toExponential(e);return i.length>e&&(i=t.toExponential(Math.max(0,e-(i.length-e)))),i.slice(0)}function w(t,e,s){let n=s?t.rows:t.rows-1;if(e<0||e>n)throw new RangeError("Row index out of range")}function b(t,e,s){let n=s?t.columns:t.columns-1;if(e<0||e>n)throw new RangeError("Column index out of range")}function v(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.columns)throw new RangeError("vector size must be the same as the number of columns");return e}function C(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.rows)throw new RangeError("vector size must be the same as the number of rows");return e}function S(t,e,s,n,i){if(5!==arguments.length)throw new RangeError("expected 4 arguments");if(A("startRow",e),A("endRow",s),A("startColumn",n),A("endColumn",i),e>s||n>i||e<0||e>=t.rows||s<0||s>=t.rows||n<0||n>=t.columns||i<0||i>=t.columns)throw new RangeError("Submatrix indices are out of range")}function M(t,e=0){let s=[];for(let n=0;n<t;n++)s.push(e);return s}function A(t,e){if("number"!=typeof e)throw new TypeError(`${t} must be a number`)}function T(t){if(t.isEmpty())throw new Error("Empty matrix has no elements to index")}class E{static from1DArray(t,e,s){if(t*e!==s.length)throw new RangeError("data length does not match given dimensions");let n=new N(t,e);for(let i=0;i<t;i++)for(let t=0;t<e;t++)n.set(i,t,s[i*e+t]);return n}static rowVector(t){let e=new N(1,t.length);for(let s=0;s<t.length;s++)e.set(0,s,t[s]);return e}static columnVector(t){let e=new N(t.length,1);for(let s=0;s<t.length;s++)e.set(s,0,t[s]);return e}static zeros(t,e){return new N(t,e)}static ones(t,e){return new N(t,e).fill(1)}static rand(t,e,s={}){if("object"!=typeof s)throw new TypeError("options must be an object");const{random:n=Math.random}=s;let i=new N(t,e);for(let s=0;s<t;s++)for(let t=0;t<e;t++)i.set(s,t,n());return i}static randInt(t,e,s={}){if("object"!=typeof s)throw new TypeError("options must be an object");const{min:n=0,max:i=1e3,random:r=Math.random}=s;if(!Number.isInteger(n))throw new TypeError("min must be an integer");if(!Number.isInteger(i))throw new TypeError("max must be an integer");if(n>=i)throw new RangeError("min must be smaller than max");let o=i-n,a=new N(t,e);for(let s=0;s<t;s++)for(let t=0;t<e;t++){let e=n+Math.round(r()*o);a.set(s,t,e)}return a}static eye(t,e,s){void 0===e&&(e=t),void 0===s&&(s=1);let n=Math.min(t,e),i=this.zeros(t,e);for(let t=0;t<n;t++)i.set(t,t,s);return i}static diag(t,e,s){let n=t.length;void 0===e&&(e=n),void 0===s&&(s=e);let i=Math.min(n,e,s),r=this.zeros(e,s);for(let e=0;e<i;e++)r.set(e,e,t[e]);return r}static min(t,e){t=this.checkMatrix(t),e=this.checkMatrix(e);let s=t.rows,n=t.columns,i=new N(s,n);for(let r=0;r<s;r++)for(let s=0;s<n;s++)i.set(r,s,Math.min(t.get(r,s),e.get(r,s)));return i}static max(t,e){t=this.checkMatrix(t),e=this.checkMatrix(e);let s=t.rows,n=t.columns,i=new this(s,n);for(let r=0;r<s;r++)for(let s=0;s<n;s++)i.set(r,s,Math.max(t.get(r,s),e.get(r,s)));return i}static checkMatrix(t){return E.isMatrix(t)?t:new N(t)}static isMatrix(t){return null!=t&&"Matrix"===t.klass}get size(){return this.rows*this.columns}apply(t){if("function"!=typeof t)throw new TypeError("callback must be a function");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.call(this,e,s);return this}to1DArray(){let t=[];for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.push(this.get(e,s));return t}to2DArray(){let t=[];for(let e=0;e<this.rows;e++){t.push([]);for(let s=0;s<this.columns;s++)t[e].push(this.get(e,s))}return t}toJSON(){return this.to2DArray()}isRowVector(){return 1===this.rows}isColumnVector(){return 1===this.columns}isVector(){return 1===this.rows||1===this.columns}isSquare(){return this.rows===this.columns}isEmpty(){return 0===this.rows||0===this.columns}isSymmetric(){if(this.isSquare()){for(let t=0;t<this.rows;t++)for(let e=0;e<=t;e++)if(this.get(t,e)!==this.get(e,t))return!1;return!0}return!1}isEchelonForm(){let t=0,e=0,s=-1,n=!0,i=!1;for(;t<this.rows&&n;){for(e=0,i=!1;e<this.columns&&!1===i;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(i=!0,s=e):(n=!1,i=!0);t++}return n}isReducedEchelonForm(){let t=0,e=0,s=-1,n=!0,i=!1;for(;t<this.rows&&n;){for(e=0,i=!1;e<this.columns&&!1===i;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(i=!0,s=e):(n=!1,i=!0);for(let s=e+1;s<this.rows;s++)0!==this.get(t,s)&&(n=!1);t++}return n}echelonForm(){let t=this.clone(),e=0,s=0;for(;e<t.rows&&s<t.columns;){let n=e;for(let i=e;i<t.rows;i++)t.get(i,s)>t.get(n,s)&&(n=i);if(0===t.get(n,s))s++;else{t.swapRows(e,n);let i=t.get(e,s);for(let n=s;n<t.columns;n++)t.set(e,n,t.get(e,n)/i);for(let n=e+1;n<t.rows;n++){let i=t.get(n,s)/t.get(e,s);t.set(n,s,0);for(let r=s+1;r<t.columns;r++)t.set(n,r,t.get(n,r)-t.get(e,r)*i)}e++,s++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,s=t.rows,n=s-1;for(;n>=0;)if(0===t.maxRow(n))n--;else{let i=0,r=!1;for(;i<s&&!1===r;)1===t.get(n,i)?r=!0:i++;for(let s=0;s<n;s++){let r=t.get(s,i);for(let o=i;o<e;o++){let e=t.get(s,o)-r*t.get(n,o);t.set(s,o,e)}}n--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:s=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(s)||s<=0)throw new TypeError("columns must be a positive integer");let n=new N(this.rows*e,this.columns*s);for(let t=0;t<e;t++)for(let e=0;e<s;e++)n.setSubMatrix(this,this.rows*t,this.columns*e);return n}fill(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,t);return this}neg(){return this.mulS(-1)}getRow(t){w(this,t);let e=[];for(let s=0;s<this.columns;s++)e.push(this.get(t,s));return e}getRowVector(t){return N.rowVector(this.getRow(t))}setRow(t,e){w(this,t),e=v(this,e);for(let s=0;s<this.columns;s++)this.set(t,s,e[s]);return this}swapRows(t,e){w(this,t),w(this,e);for(let s=0;s<this.columns;s++){let n=this.get(t,s);this.set(t,s,this.get(e,s)),this.set(e,s,n)}return this}getColumn(t){b(this,t);let e=[];for(let s=0;s<this.rows;s++)e.push(this.get(s,t));return e}getColumnVector(t){return N.columnVector(this.getColumn(t))}setColumn(t,e){b(this,t),e=C(this,e);for(let s=0;s<this.rows;s++)this.set(s,t,e[s]);return this}swapColumns(t,e){b(this,t),b(this,e);for(let s=0;s<this.rows;s++){let n=this.get(s,t);this.set(s,t,this.get(s,e)),this.set(s,e,n)}return this}addRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[s]);return this}subRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[s]);return this}mulRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[s]);return this}divRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[s]);return this}addColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[e]);return this}subColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[e]);return this}mulColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[e]);return this}divColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[e]);return this}mulRow(t,e){w(this,t);for(let s=0;s<this.columns;s++)this.set(t,s,this.get(t,s)*e);return this}mulColumn(t,e){b(this,t);for(let s=0;s<this.rows;s++)this.set(s,t,this.get(s,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){T(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let n=0;n<this.columns;n++)this.get(s,n)>t&&(t=this.get(s,n),e[0]=s,e[1]=n);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){T(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let n=0;n<this.columns;n++)this.get(s,n)<t&&(t=this.get(s,n),e[0]=s,e[1]=n);return e}maxRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)>e&&(e=this.get(t,s));return e}maxRowIndex(t){w(this,t),T(this);let e=this.get(t,0),s=[t,0];for(let n=1;n<this.columns;n++)this.get(t,n)>e&&(e=this.get(t,n),s[1]=n);return s}minRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){w(this,t),T(this);let e=this.get(t,0),s=[t,0];for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n),s[1]=n);return s}maxColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t),s[0]=n);return s}minColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t),s[0]=n);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let n=0;n<e.length;n++)s+=e[n]*t[n];return s}mmul(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,n=t.columns,i=new N(e,n),r=new Float64Array(s);for(let o=0;o<n;o++){for(let e=0;e<s;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let n=0;n<s;n++)e+=this.get(t,n)*r[n];i.set(t,o,e)}}return i}strassen2x2(t){t=N.checkMatrix(t);let e=new N(2,2);const s=this.get(0,0),n=t.get(0,0),i=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(n+h),u=(o+l)*n,m=s*(r-h),d=l*(a-n),p=(s+i)*h,g=c+d-p+(i-l)*(a+h),f=m+p,y=u+d,w=c-u+m+(o-s)*(n+r);return e.set(0,0,g),e.set(0,1,f),e.set(1,0,y),e.set(1,1,w),e}strassen3x3(t){t=N.checkMatrix(t);let e=new N(3,3);const s=this.get(0,0),n=this.get(0,1),i=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),p=t.get(1,0),g=t.get(1,1),f=t.get(1,2),y=t.get(2,0),w=t.get(2,1),b=t.get(2,2),v=(s-r)*(-m+g),C=(-s+r+o)*(u-m+g),S=(r+o)*(-u+m),M=s*u,A=(-s+l+h)*(u-d+f),T=(-s+l)*(d-f),E=(l+h)*(-u+d),x=(-i+h+c)*(g+y-w),L=(i-c)*(g-w),I=i*y,_=(h+c)*(-y+w),R=(-i+o+a)*(f+y-b),O=(i-a)*(f-b),k=(o+a)*(-y+b),P=M+I+n*p,G=(s+n+i-r-o-h-c)*g+C+S+M+x+I+_,F=M+A+E+(s+n+i-o-a-l-h)*f+I+R+k,W=v+o*(-u+m+p-g-f-y+b)+C+M+I+R+O,V=v+C+S+M+a*w,H=I+R+O+k+r*d,D=M+A+T+h*(-u+d+p-g-f-y+w)+x+L+I,B=x+L+I+_+l*m,U=M+A+T+E+c*b;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,D),e.set(2,1,B),e.set(2,2,U),e}mmulStrassen(t){t=N.checkMatrix(t);let e=this.clone(),s=e.rows,n=e.columns,i=t.rows,r=t.columns;function o(t,e,s){let n=t.rows,i=t.columns;if(n===e&&i===s)return t;{let n=E.zeros(e,s);return n=n.setSubMatrix(t,0,0),n}}n!==i&&console.warn(`Multiplying ${s} x ${n} and ${i} x ${r} matrix: dimensions do not match.`);let a=Math.max(s,i),l=Math.max(n,r);return e=o(e,a,l),function t(e,s,n,i){if(n<=512||i<=512)return e.mmul(s);n%2==1&&i%2==1?(e=o(e,n+1,i+1),s=o(s,n+1,i+1)):n%2==1?(e=o(e,n+1,i),s=o(s,n+1,i)):i%2==1&&(e=o(e,n,i+1),s=o(s,n,i+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=s.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=s.subMatrix(0,r-1,a,s.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=s.subMatrix(r,s.rows-1,0,a-1),p=e.subMatrix(r,e.rows-1,a,e.columns-1),g=s.subMatrix(r,s.rows-1,a,s.columns-1),f=t(E.add(l,p),E.add(h,g),r,a),y=t(E.add(m,p),h,r,a),w=t(l,E.sub(u,g),r,a),b=t(p,E.sub(d,h),r,a),v=t(E.add(l,c),g,r,a),C=t(E.sub(m,l),E.add(h,u),r,a),S=t(E.sub(c,p),E.add(d,g),r,a),M=E.add(f,b);M.sub(v),M.add(S);let A=E.add(w,v),T=E.add(y,b),x=E.sub(f,y);x.add(w),x.add(C);let N=E.zeros(2*M.rows,2*M.columns);return N=N.setSubMatrix(M,0,0),N=N.setSubMatrix(A,M.rows,0),N=N.setSubMatrix(T,0,M.columns),N=N.setSubMatrix(x,M.rows,M.columns),N.subMatrix(0,n-1,0,i-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new N(this.rows,this.columns);for(let t=0;t<this.rows;t++){const i=this.getRow(t);i.length>0&&m(i,{min:e,max:s,output:i}),n.setRow(t,i)}return n}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new N(this.rows,this.columns);for(let t=0;t<this.columns;t++){const i=this.getColumn(t);i.length&&m(i,{min:e,max:s,output:i}),n.setColumn(t,i)}return n}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let s=0;s<t;s++){let t=this.get(e,s),n=this.get(e,this.columns-1-s);this.set(e,s,n),this.set(e,this.columns-1-s,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let s=0;s<t;s++){let t=this.get(s,e),n=this.get(this.rows-1-s,e);this.set(s,e,n),this.set(this.rows-1-s,e,t)}return this}kroneckerProduct(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,n=t.rows,i=t.columns,r=new N(e*n,s*i);for(let o=0;o<e;o++)for(let e=0;e<s;e++)for(let s=0;s<n;s++)for(let a=0;a<i;a++)r.set(n*o+s,i*e+a,this.get(o,e)*t.get(s,a));return r}kroneckerSum(t){if(t=N.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,s=t.rows,n=this.kroneckerProduct(N.eye(s,s)),i=N.eye(e,e).kroneckerProduct(t);return n.add(i)}transpose(){let t=new N(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(s,e,this.get(e,s));return t}sortRows(t=x){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=x){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,s,n){S(this,t,e,s,n);let i=new N(e-t+1,n-s+1);for(let r=t;r<=e;r++)for(let e=s;e<=n;e++)i.set(r-t,e-s,this.get(r,e));return i}subMatrixRow(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.columns-1),e>s||e<0||e>=this.columns||s<0||s>=this.columns)throw new RangeError("Argument out of range");let n=new N(t.length,s-e+1);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.rows)throw new RangeError(`Row index out of range: ${t[i]}`);n.set(i,r-e,this.get(t[i],r))}return n}subMatrixColumn(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.rows-1),e>s||e<0||e>=this.rows||s<0||s>=this.rows)throw new RangeError("Argument out of range");let n=new N(s-e+1,t.length);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.columns)throw new RangeError(`Column index out of range: ${t[i]}`);n.set(r-e,i,this.get(r,t[i]))}return n}setSubMatrix(t,e,s){if((t=N.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,s,s+t.columns-1);for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)this.set(e+n,s+i,t.get(n,i));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let s=new N(t.length,e.length);for(let n=0;n<t.length;n++){let i=t[n];for(let t=0;t<e.length;t++){let r=e[t];s.set(n,t,this.get(i,r))}}return s}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let s=0;s<t;s++)e+=this.get(s,s);return e}clone(){let t=new N(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(e,s,this.get(e,s));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]+=t.get(s,n);return e}(this);case"column":return function(t){let e=M(t.columns);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]+=t.get(s,n);return e}(this);case void 0:return function(t){let e=0;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e+=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]*=t.get(s,n);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]*=t.get(s,n);return e}(this);case void 0:return function(t){let e=1;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e*=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:s=!0,mean:n=this.mean(t)}=e;if("boolean"!=typeof s)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<n;o++){let n=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(o,e)-s[o],n+=l,a+=l*l;e?r.push((a-n*n/i)/(i-1)):r.push((a-n*n/i)/i)}return r}(this,s,n);case"column":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<n;e++)l=t.get(e,o)-s[o],i+=l,a+=l*l;e?r.push((a-i*i/n)/(n-1)):r.push((a-i*i/n)/n)}return r}(this,s,n);case void 0:if("number"!=typeof n)throw new TypeError("mean must be a number");return function(t,e,s){const n=t.rows,i=t.columns,r=n*i;let o=0,a=0,l=0;for(let e=0;e<n;e++)for(let n=0;n<i;n++)l=t.get(e,n)-s,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,s,n);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const s=this.variance(t,e);if(void 0===t)return Math.sqrt(s);for(let t=0;t<s.length;t++)s[t]=Math.sqrt(s[t]);return s}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:s=this.mean(t)}=e;switch(t){case"row":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[s])}(this,s),this;case"column":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[n])}(this,s),this;case void 0:if("number"!=typeof s)throw new TypeError("center must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let s=e.scale;switch(t){case"row":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.rows;s++){let n=0;for(let e=0;e<t.columns;e++)n+=Math.pow(t.get(s,e),2)/(t.columns-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[s])}(this,s),this;case"column":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.columns;s++){let n=0;for(let e=0;e<t.rows;e++)n+=Math.pow(t.get(e,s),2)/(t.rows-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[n])}(this,s),this;case void 0:if(void 0===s)s=function(t){const e=t.size-1;let s=0;for(let n=0;n<t.columns;n++)for(let i=0;i<t.rows;i++)s+=Math.pow(t.get(i,n),2)/e;return Math.sqrt(s)}(this);else if("number"!=typeof s)throw new TypeError("scale must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return g(this,t)}}function x(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return g(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class N extends E{constructor(t,e){if(super(),N.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let s=0;s<t;s++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const s=t;if("number"!=typeof(e=(t=s.length)?s[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let n=0;n<t;n++){if(s[n].length!==e)throw new RangeError("Inconsistent array dimensions");if(!s[n].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(s[n]))}}}this.rows=t,this.columns=e}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}removeRow(t){return w(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),w(this,t,!0),e=Float64Array.from(v(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){b(this,t);for(let e=0;e<this.rows;e++){const s=new Float64Array(this.columns-1);for(let n=0;n<t;n++)s[n]=this.data[e][n];for(let n=t+1;n<this.columns;n++)s[n-1]=this.data[e][n];this.data[e]=s}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),b(this,t,!0),e=C(this,e);for(let s=0;s<this.rows;s++){const n=new Float64Array(this.columns+1);let i=0;for(;i<t;i++)n[i]=this.data[s][i];for(n[i++]=e[s];i<this.columns+1;i++)n[i]=this.data[s][i-1];this.data[s]=n}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t.get(e,s));return this},t.add=function(t,s){return new e(t).add(s)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t.get(e,s));return this},t.sub=function(t,s){return new e(t).sub(s)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t.get(e,s));return this},t.mul=function(t,s){return new e(t).mul(s)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t.get(e,s));return this},t.div=function(t,s){return new e(t).div(s)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t.get(e,s));return this},t.mod=function(t,s){return new e(t).mod(s)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t.get(e,s));return this},t.and=function(t,s){return new e(t).and(s)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t.get(e,s));return this},t.or=function(t,s){return new e(t).or(s)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t.get(e,s));return this},t.xor=function(t,s){return new e(t).xor(s)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t.get(e,s));return this},t.leftShift=function(t,s){return new e(t).leftShift(s)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t.get(e,s));return this},t.signPropagatingRightShift=function(t,s){return new e(t).signPropagatingRightShift(s)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t.get(e,s));return this},t.rightShift=function(t,s){return new e(t).rightShift(s)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,s){return new e(t).pow(s)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t.get(e,s)));return this}}(E,N);class L extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}}class I{constructor(t){let e,s,n,i,r,o,a,l,h,c=(t=L.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),p=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),s=0;s<m;s++){for(e=0;e<u;e++)l[e]=c.get(e,s);for(e=0;e<u;e++){for(h=Math.min(e,s),r=0,n=0;n<h;n++)r+=c.get(e,n)*l[n];l[e]-=r,c.set(e,s,l[e])}for(i=s,e=s+1;e<u;e++)Math.abs(l[e])>Math.abs(l[i])&&(i=e);if(i!==s){for(n=0;n<m;n++)o=c.get(i,n),c.set(i,n,c.get(s,n)),c.set(s,n,o);a=d[i],d[i]=d[s],d[s]=a,p=-p}if(s<u&&0!==c.get(s,s))for(e=s+1;e<u;e++)c.set(e,s,c.get(e,s)/c.get(s,s))}this.LU=c,this.pivotVector=d,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=N.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,n,i,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(i=0;i<a;i++)for(s=i+1;s<a;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i));for(i=a-1;i>=0;i--){for(n=0;n<r;n++)o.set(i,n,o.get(i,n)/e.get(i,i));for(s=0;s<i;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let n=0;n<s;n++)e*=t.get(n,n);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new N(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i>e?n.set(i,e,t.get(i,e)):i===e?n.set(i,e,1):n.set(i,e,0);return n}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new N(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i<=e?n.set(i,e,t.get(i,e)):n.set(i,e,0);return n}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function _(t,e){let s=0;return Math.abs(t)>Math.abs(e)?(s=e/t,Math.abs(t)*Math.sqrt(1+s*s)):0!==e?(s=t/e,Math.abs(e)*Math.sqrt(1+s*s)):0}class R{constructor(t){let e,s,n,i,r=(t=L.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(n=0;n<a;n++){let t=0;for(e=n;e<o;e++)t=_(t,r.get(e,n));if(0!==t){for(r.get(n,n)<0&&(t=-t),e=n;e<o;e++)r.set(e,n,r.get(e,n)/t);for(r.set(n,n,r.get(n,n)+1),s=n+1;s<a;s++){for(i=0,e=n;e<o;e++)i+=r.get(e,n)*r.get(e,s);for(i=-i/r.get(n,n),e=n;e<o;e++)r.set(e,s,r.get(e,s)+i*r.get(e,n))}}l[n]=-t}this.QR=r,this.Rdiag=l}solve(t){t=N.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let n,i,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(i=0;i<a;i++){for(o=0,n=r;n<s;n++)o+=e.get(n,r)*l.get(n,i);for(o=-o/e.get(r,r),n=r;n<s;n++)l.set(n,i,l.get(n,i)+o*e.get(n,r))}for(r=h-1;r>=0;r--){for(i=0;i<a;i++)l.set(r,i,l.get(r,i)/this.Rdiag[r]);for(n=0;n<r;n++)for(i=0;i<a;i++)l.set(n,i,l.get(n,i)-l.get(r,i)*e.get(n,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,n=s.columns,i=new N(n,n);for(t=0;t<n;t++)for(e=0;e<n;e++)t<e?i.set(t,e,s.get(t,e)):t===e?i.set(t,e,this.Rdiag[t]):i.set(t,e,0);return i}get orthogonalMatrix(){let t,e,s,n,i=this.QR,r=i.rows,o=i.columns,a=new N(r,o);for(s=o-1;s>=0;s--){for(t=0;t<r;t++)a.set(t,s,0);for(a.set(s,s,1),e=s;e<o;e++)if(0!==i.get(s,s)){for(n=0,t=s;t<r;t++)n+=i.get(t,s)*a.get(t,e);for(n=-n/i.get(s,s),t=s;t<r;t++)a.set(t,e,a.get(t,e)+n*i.get(t,s))}}return a}}class O{constructor(t,e={}){if((t=L.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,n=t.columns;const{computeLeftSingularVectors:i=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(i),h=Boolean(r),c=!1;if(s<n)if(o){a=t.transpose(),s=a.rows,n=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(s,n),m=Math.min(s+1,n),d=new Float64Array(m),p=new N(s,u),g=new N(n,n),f=new Float64Array(n),y=new Float64Array(s),w=new Float64Array(m);for(let t=0;t<m;t++)w[t]=t;let b=Math.min(s-1,n),v=Math.max(0,Math.min(n-2,s)),C=Math.max(b,v);for(let t=0;t<C;t++){if(t<b){d[t]=0;for(let e=t;e<s;e++)d[t]=_(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<s;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<n;e++){if(t<b&&0!==d[t]){let n=0;for(let i=t;i<s;i++)n+=a.get(i,t)*a.get(i,e);n=-n/a.get(t,t);for(let i=t;i<s;i++)a.set(i,e,a.get(i,e)+n*a.get(i,t))}f[e]=a.get(t,e)}if(l&&t<b)for(let e=t;e<s;e++)p.set(e,t,a.get(e,t));if(t<v){f[t]=0;for(let e=t+1;e<n;e++)f[t]=_(f[t],f[e]);if(0!==f[t]){f[t+1]<0&&(f[t]=0-f[t]);for(let e=t+1;e<n;e++)f[e]/=f[t];f[t+1]+=1}if(f[t]=-f[t],t+1<s&&0!==f[t]){for(let e=t+1;e<s;e++)y[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<n;s++)y[e]+=f[s]*a.get(e,s);for(let e=t+1;e<n;e++){let n=-f[e]/f[t+1];for(let i=t+1;i<s;i++)a.set(i,e,a.get(i,e)+n*y[i])}}if(h)for(let e=t+1;e<n;e++)g.set(e,t,f[e])}}let S=Math.min(n,s+1);if(b<n&&(d[b]=a.get(b,b)),s<S&&(d[S-1]=0),v+1<S&&(f[v]=a.get(v,S-1)),f[S-1]=0,l){for(let t=b;t<u;t++){for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}for(let t=b-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let n=0;for(let i=t;i<s;i++)n+=p.get(i,t)*p.get(i,e);n=-n/p.get(t,t);for(let i=t;i<s;i++)p.set(i,e,p.get(i,e)+n*p.get(i,t))}for(let e=t;e<s;e++)p.set(e,t,-p.get(e,t));p.set(t,t,1+p.get(t,t));for(let e=0;e<t-1;e++)p.set(e,t,0)}else{for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}}if(h)for(let t=n-1;t>=0;t--){if(t<v&&0!==f[t])for(let e=t+1;e<n;e++){let s=0;for(let i=t+1;i<n;i++)s+=g.get(i,t)*g.get(i,e);s=-s/g.get(t+1,t);for(let i=t+1;i<n;i++)g.set(i,e,g.get(i,e)+s*g.get(i,t))}for(let e=0;e<n;e++)g.set(e,t,0);g.set(t,t,1)}let M=S-1,A=0,T=Number.EPSILON;for(;S>0;){let t,e;for(t=S-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+T*Math.abs(d[t]+Math.abs(d[t+1]));if(Math.abs(f[t])<=e||Number.isNaN(f[t])){f[t]=0;break}}if(t===S-2)e=4;else{let s;for(s=S-1;s>=t&&s!==t;s--){let e=(s!==S?Math.abs(f[s]):0)+(s!==t+1?Math.abs(f[s-1]):0);if(Math.abs(d[s])<=T*e){d[s]=0;break}}s===t?e=3:s===S-1?e=1:(e=2,t=s)}switch(t++,e){case 1:{let e=f[S-2];f[S-2]=0;for(let s=S-2;s>=t;s--){let i=_(d[s],e),r=d[s]/i,o=e/i;if(d[s]=i,s!==t&&(e=-o*f[s-1],f[s-1]=r*f[s-1]),h)for(let t=0;t<n;t++)i=r*g.get(t,s)+o*g.get(t,S-1),g.set(t,S-1,-o*g.get(t,s)+r*g.get(t,S-1)),g.set(t,s,i)}break}case 2:{let e=f[t-1];f[t-1]=0;for(let n=t;n<S;n++){let i=_(d[n],e),r=d[n]/i,o=e/i;if(d[n]=i,e=-o*f[n],f[n]=r*f[n],l)for(let e=0;e<s;e++)i=r*p.get(e,n)+o*p.get(e,t-1),p.set(e,t-1,-o*p.get(e,n)+r*p.get(e,t-1)),p.set(e,n,i)}break}case 3:{const e=Math.max(Math.abs(d[S-1]),Math.abs(d[S-2]),Math.abs(f[S-2]),Math.abs(d[t]),Math.abs(f[t])),i=d[S-1]/e,r=d[S-2]/e,o=f[S-2]/e,a=d[t]/e,c=f[t]/e,u=((r+i)*(r-i)+o*o)/2,m=i*o*(i*o);let y=0;0===u&&0===m||(y=u<0?0-Math.sqrt(u*u+m):Math.sqrt(u*u+m),y=m/(u+y));let w=(a+i)*(a-i)+y,b=a*c;for(let e=t;e<S-1;e++){let i=_(w,b);0===i&&(i=Number.MIN_VALUE);let r=w/i,o=b/i;if(e!==t&&(f[e-1]=i),w=r*d[e]+o*f[e],f[e]=r*f[e]-o*d[e],b=o*d[e+1],d[e+1]=r*d[e+1],h)for(let t=0;t<n;t++)i=r*g.get(t,e)+o*g.get(t,e+1),g.set(t,e+1,-o*g.get(t,e)+r*g.get(t,e+1)),g.set(t,e,i);if(i=_(w,b),0===i&&(i=Number.MIN_VALUE),r=w/i,o=b/i,d[e]=i,w=r*f[e]+o*d[e+1],d[e+1]=-o*f[e]+r*d[e+1],b=o*f[e+1],f[e+1]=r*f[e+1],l&&e<s-1)for(let t=0;t<s;t++)i=r*p.get(t,e)+o*p.get(t,e+1),p.set(t,e+1,-o*p.get(t,e)+r*p.get(t,e+1)),p.set(t,e,i)}f[S-2]=w,A+=1;break}case 4:if(d[t]<=0&&(d[t]=d[t]<0?-d[t]:0,h))for(let e=0;e<=M;e++)g.set(e,t,-g.get(e,t));for(;t<M&&!(d[t]>=d[t+1]);){let e=d[t];if(d[t]=d[t+1],d[t+1]=e,h&&t<n-1)for(let s=0;s<n;s++)e=g.get(s,t+1),g.set(s,t+1,g.get(s,t)),g.set(s,t,e);if(l&&t<s-1)for(let n=0;n<s;n++)e=p.get(n,t+1),p.set(n,t+1,p.get(n,t)),p.set(n,t,e);t++}A=0,S--}}if(c){let t=g;g=p,p=t}this.m=s,this.n=n,this.s=d,this.U=p,this.V=g}solve(t){let e=t,s=this.threshold,n=this.s.length,i=N.zeros(n,n);for(let t=0;t<n;t++)Math.abs(this.s[t])<=s?i.set(t,t,0):i.set(t,t,1/this.s[t]);let r=this.U,o=this.rightSingularVectors,a=o.mmul(i),l=o.rows,h=r.rows,c=N.zeros(l,h);for(let t=0;t<l;t++)for(let e=0;e<h;e++){let s=0;for(let i=0;i<n;i++)s+=a.get(t,i)*r.get(e,i);c.set(t,e,s)}return c.mmul(e)}solveForDiagonal(t){return this.solve(N.diag(t))}inverse(){let t=this.V,e=this.threshold,s=t.rows,n=t.columns,i=new N(s,this.s.length);for(let r=0;r<s;r++)for(let s=0;s<n;s++)Math.abs(this.s[s])>e&&i.set(r,s,t.get(r,s)/this.s[s]);let r=this.U,o=r.rows,a=r.columns,l=new N(s,o);for(let t=0;t<s;t++)for(let e=0;e<o;e++){let s=0;for(let n=0;n<a;n++)s+=i.get(t,n)*r.get(e,n);l.set(t,e,s)}return l}get condition(){return this.s[0]/this.s[Math.min(this.m,this.n)-1]}get norm2(){return this.s[0]}get rank(){let t=Math.max(this.m,this.n)*this.s[0]*Number.EPSILON,e=0,s=this.s;for(let n=0,i=s.length;n<i;n++)s[n]>t&&e++;return e}get diagonal(){return Array.from(this.s)}get threshold(){return Number.EPSILON/2*Math.max(this.m,this.n)*this.s[0]}get leftSingularVectors(){return this.U}get rightSingularVectors(){return this.V}get diagonalMatrix(){return N.diag(this.s)}}function k(t,e,s,n,i){let r=s*n*n,o=N.eye(e.length,e.length,r);const a=i(e);let l=new Float64Array(t.x.length);for(let e=0;e<t.x.length;e++)l[e]=a(t.x[e]);let h=function(t,e,s,n,i){const r=s.length,o=t.x.length;let a=new Array(r);for(let l=0;l<r;l++){a[l]=new Array(o);let r=s.slice();r[l]+=n;let h=i(r);for(let s=0;s<o;s++)a[l][s]=e[s]-h(t.x[s])}return new N(a)}(t,l,e,n,i),c=function(t,e){const s=t.x.length;let n=new Array(s);for(let i=0;i<s;i++)n[i]=[t.y[i]-e[i]];return new N(n)}(t,l),u=function(t,e=!1){return t=L.checkMatrix(t),e?new O(t).inverse():function(t,e,s=!1){return t=L.checkMatrix(t),e=L.checkMatrix(e),s?new O(t).solve(e):t.isSquare()?new I(t).solve(e):new R(t).solve(e)}(t,N.eye(t.rows))}(o.add(h.mmul(h.transpose())));return(e=(e=new N([e])).sub(u.mmul(h).mmul(c).mul(n).transpose())).to1DArray()}function P(t,e,s={}){let{maxIterations:n=100,gradientDifference:o=.1,damping:a=0,errorTolerance:l=.01,minValues:h,maxValues:c,initialValues:u}=s;if(a<=0)throw new Error("The damping option must be a positive number");if(!t.x||!t.y)throw new Error("The data parameter must have x and y elements");if(!i(t.x)||t.x.length<2||!i(t.y)||t.y.length<2)throw new Error("The data parameter elements must be an array with more than 2 points");if(t.x.length!==t.y.length)throw new Error("The data parameter elements must have the same size");let m=u||new Array(e.length).fill(1),d=m.length;if(c=c||new Array(d).fill(Number.MAX_SAFE_INTEGER),h=h||new Array(d).fill(Number.MIN_SAFE_INTEGER),c.length!==h.length)throw new Error("minValues and maxValues must be the same size");if(!i(m))throw new Error("initialValues must be an array");let p,g=r(t,m,e),f=g<=l;for(p=0;p<n&&!f;p++){m=k(t,m,a,o,e);for(let t=0;t<d;t++)m[t]=Math.min(Math.max(h[t],m[t]),c[t]);if(g=r(t,m,e),isNaN(g))break;f=g<=l}return{parameterValues:m,parameterError:g,iterations:p}}},3379:t=>{"use strict";var e=[];function s(t){for(var s=-1,n=0;n<e.length;n++)if(e[n].identifier===t){s=n;break}return s}function n(t,n){for(var r={},o=[],a=0;a<t.length;a++){var l=t[a],h=n.base?l[0]+n.base:l[0],c=r[h]||0,u="".concat(h," ").concat(c);r[h]=c+1;var m=s(u),d={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==m)e[m].references++,e[m].updater(d);else{var p=i(d,n);n.byIndex=a,e.splice(a,0,{identifier:u,updater:p,references:1})}o.push(u)}return o}function i(t,e){var s=e.domAPI(e);return s.update(t),function(e){if(e){if(e.css===t.css&&e.media===t.media&&e.sourceMap===t.sourceMap&&e.supports===t.supports&&e.layer===t.layer)return;s.update(t=e)}else s.remove()}}t.exports=function(t,i){var r=n(t=t||[],i=i||{});return function(t){t=t||[];for(var o=0;o<r.length;o++){var a=s(r[o]);e[a].references--}for(var l=n(t,i),h=0;h<r.length;h++){var c=s(r[h]);0===e[c].references&&(e[c].updater(),e.splice(c,1))}r=l}}},569:t=>{"use strict";var e={};t.exports=function(t,s){var n=function(t){if(void 0===e[t]){var s=document.querySelector(t);if(window.HTMLIFrameElement&&s instanceof window.HTMLIFrameElement)try{s=s.contentDocument.head}catch(t){s=null}e[t]=s}return e[t]}(t);if(!n)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");n.appendChild(s)}},9216:t=>{"use strict";t.exports=function(t){var e=document.createElement("style");return t.setAttributes(e,t.attributes),t.insert(e,t.options),e}},3565:(t,e,s)=>{"use strict";t.exports=function(t){var e=s.nc;e&&t.setAttribute("nonce",e)}},7795:t=>{"use strict";t.exports=function(t){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var e=t.insertStyleElement(t);return{update:function(s){!function(t,e,s){var n="";s.supports&&(n+="@supports (".concat(s.supports,") {")),s.media&&(n+="@media ".concat(s.media," {"));var i=void 0!==s.layer;i&&(n+="@layer".concat(s.layer.length>0?" ".concat(s.layer):""," {")),n+=s.css,i&&(n+="}"),s.media&&(n+="}"),s.supports&&(n+="}");var r=s.sourceMap;r&&"undefined"!=typeof btoa&&(n+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(r))))," */")),e.styleTagTransform(n,t,e.options)}(e,t,s)},remove:function(){!function(t){if(null===t.parentNode)return!1;t.parentNode.removeChild(t)}(e)}}}},4589:t=>{"use strict";t.exports=function(t,e){if(e.styleSheet)e.styleSheet.cssText=t;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(t))}}},7241:(t,e,s)=>{"use strict";s.d(e,{D:()=>c});var n=s(4469),i=s(976),r=s(6414),o=s.n(r),a=s(4941),l=s(499);const h=31;async function c(t,e=!1,s){const r=l.Cn.getOrCreate(t);let c;s??(s=new Map);const m=r.isHelm()?(0,a.getHelmMonomers)(t):Object.keys(r.stats.freq).filter((t=>""!==t));for(let t=0;t<m.length;t++)s.has(m[t])||s.set(m[t],`${s.size+1}`);if(r.isHelm())c=await n.functions.call("HELM:getMolFiles",{col:t}),c=function(t,e,s=!1){const n=new Array(t.length);for(let i=0;i<t.length;i++){let r=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=t.get(i);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const c=parseInt(l.substring(r,r+3)),u=parseInt(l.substring(r+3,r+6));a+=`M V30 COUNTS ${c} ${u} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let t=0;t<c;t++){r=l.indexOf("\n",r)+1+h,o=l.indexOf(" ",r);const n=l.substring(r,o);a+=s?`M V30 ${t+1} R${e.get(n)} 0.000 0.000 0 0\n`:`M V30 ${t+1} At 0.000 0.000 0 0 MASS=${e.get(n)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let t=0;t<u;t++){r=l.indexOf("\n",r)+1;const e=parseInt(l.substring(r,r+3).trim()),s=parseInt(l.substring(r+3,r+6).trim());a+=`M V30 ${t+1} ${parseInt(l.substring(r+6,r+9).trim())} ${e} ${s}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",n[i]=a}return n}(c,s,e);else{c=new Array(t.length);for(let n=0;n<t.length;n++){const t=u(o()(r.splitted[n]).filter((t=>""!==t)).toArray(),s,e);c[n]=t}}return i.Column.fromStrings("monomericMols",c)}function u(t,e,s=!1){let n="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";n+=`M V30 COUNTS ${t.length} ${t.length?t.length-1:0} 0 0 0\n`,n+="M V30 BEGIN ATOM\n";for(let i=0;i<t.length;i++)n+=s?`M V30 ${i+1} R${e.get(t[i])} 0.000 0.000 0 0\n`:`M V30 ${i+1} At 0.000 0.000 0 0 MASS=${e.get(t[i])}\n`;n+="M V30 END ATOM\n",n+="M V30 BEGIN BOND\n";for(let e=0;e<t.length-1;e++)n+=`M V30 ${e+1} 1 ${e+1} ${e+2}\n`;return n+="M V30 END BOND\n",n+="M V30 END CTAB\n",n+="M END",n}},4941:(t,e,s)=>{"use strict";s.r(e),s.d(e,{GetRegionEditor:()=>De,SeqActivityCliffsEditor:()=>Ze,SeqPaletteCustom:()=>Pe,SequenceSpaceEditor:()=>Ue,SplitToMonomersEditor:()=>Be,SubsequenceSearchTopMenu:()=>Cs,_package:()=>Re,activityCliffs:()=>ss,addCopyMenu:()=>Ns,alignSequences:()=>os,bioSubstructureFilter:()=>Ts,compositionAnalysis:()=>as,compositionAnalysisWidget:()=>Xe,convertDialog:()=>us,demoBioActivityCliffs:()=>_s,demoBioAtomicLevel:()=>Rs,demoBioHelmMsaSequenceSpace:()=>Os,demoBioSequenceSpace:()=>Is,demoBioSimilarityDiversity:()=>Ls,diversitySearchTopMenu:()=>bs,diversitySearchViewer:()=>ws,fastaSequenceCellRenderer:()=>ze,getBioLib:()=>We,getHelmMonomers:()=>gs,getMonomerLibHelper:()=>Oe,getRegion:()=>ts,getRegionApp:()=>xs,getRegionPanel:()=>Ve,getRegionTopMenu:()=>es,hydrophobPalette:()=>ke,importBam:()=>cs,importFasta:()=>hs,initBio:()=>Ge,libraryPanel:()=>He,macroMolColumnPropertyPanel:()=>qe,macromoleculeDifferenceCellRenderer:()=>$e,monomerCellRenderer:()=>ms,multipleSequenceAlignmentDialog:()=>rs,packageSettingsEditor:()=>Ye,saveAsFasta:()=>As,sdfToJsonLib:()=>ls,searchSubsequenceEditor:()=>vs,separatorSequenceCellRenderer:()=>Ke,sequenceAlignment:()=>je,sequenceIdentityScoring:()=>Ss,sequenceSimilarityScoring:()=>Ms,sequenceSpaceTopMenu:()=>ns,sequenceTooltip:()=>Fe,similaritySearchTopMenu:()=>ys,similaritySearchViewer:()=>fs,splitToMonomersTopMenu:()=>ps,testDetectMacromolecule:()=>ds,toAtomicLevel:()=>is,vdRegionsViewer:()=>Qe,webLogoLargeApp:()=>Es,webLogoViewer:()=>Je});var n=s(4469),i=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(6066);const h="rgb(100,100,100)",c="#808080",u="rgb(0,0,0)",m=l.GU;var d;function p(t,e,s,n,i,r,o=h,a=0,l=!1,p=1,g="",f=!1,y=d.classic,w=[],b=0,v=null,C=[],S=null,M={}){i.textAlign="start";let A=r.substring(0),T=f?"":g;y===d.MSA&&(T="");let E=!0,x=!0,N="difference";null!=v&&null!=v.cell.column&&(E=v.cell.column.temp["color-code"]??!0,x=v.cell.column.temp["compare-with-current"]??!0,N=v.cell.column.temp["highlight-difference"]??"difference");const L=C[b];x&&C.length>0&&"difference"===N&&(p=A==L?.3:p),x&&C.length>0&&"equal"===N&&(p=A!=L?.3:p),null!=S&&(A=m(A,S));const I=A+T;M[I]??(M[I]=i.measureText(I));let _=M[I];M[A]??(M[A]=i.measureText(A));let R=M[A].width;M[T]??(M[T]=i.measureText(T));const O=M[T].width,k=n/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function P(s,n){const r=E?o:u;i.fillStyle=r,i.globalAlpha=p,y===d.classic&&(i.fillText(A,t+s,e+k),i.fillStyle=c,i.fillText(T,t+n,e+k)),y===d.MSA&&i.fillText(A,t+s,e+k)}_=_.width,y===d.MSA&&(R=w[b],_=w[b]);const G=(w[b]??0)-(w[0]??0);if(l||_>s)return P(G,G+R),t+G+R+O;{const e=(s-_)/2;return P(e,e+R),t+G+e+R}}!function(t){t.MSA="MSA",t.classic="classic"}(d||(d={}));var g,f=s(9611),y=s(8447),w=s(7331),b=s(499);!function(t){t.long="long",t.short="short"}(g||(g={}));const v={true:"1",false:"0"};var C=s(3553);const S="rgb(100,100,100)",M=y.GU;function A(t,e,s,n){return t?Math.min(t.canvas.width-s,n):e.canvas.width-s}function T(t){const e=!a().enumerate(t).some((([e,s])=>e.length>1&&0!=s&&s!=t.length-1)),s=[],n=e?"":" ";for(const[e,i]of a().enumerate(t)){let r=e;i<t.length&&(r+=`${e?"":"-"}${n}`),s.push(r)}return[s,e]}class E extends r.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const r=t.bounds,o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=s.getPosition(t.tableRowIndex,o),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],r=[i.div(t)];if(s._monomerStructureMap[t])r.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const i={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=n.chem.svgMol(e.smiles,void 0,void 0,i);r.push(o),s._monomerStructureMap[t]=o}}i.tooltip.show(i.divV(r),e.x+16,e.y+16)}else i.tooltip.hide()}render(t,e,s,n,i,o,l){let h=0,c=999;const u=o.grid,m=o.cell.column,g=m.temp,w=g["monomer-width"];"short"===(null!=w?w:"short")&&(c=g[".mm.cellRenderer.maxMonomerLength"]??Re.properties?.MaxMonomerLength??4);let C=m.temp["bio-seqCol"];C||(C=new f.A(u,m,(()=>{const t=b.Cn.getOrCreate(m);return{unitsHandler:t,monomerCharWidth:7,separatorWidth:t.isMsa()?8:h,monomerToShort:M,monomerLengthLimit:c,monomerLib:We()}}))),m.tags[".mm.cellRenderer.settingsChanged"]===v.true&&(h=g[".mm.cellRenderer.gapLength"]??h,C.setMonomerLengthLimit(c),C.setSeparatorWidth(C.isMsa()?8:h),m.setTag(".mm.cellRenderer.settingsChanged",v.false));const[T,E]=C.getCellMonomerLengths(o.tableRowIndex);T.length,C.updated&&(g["bio-seqCol"]=C),t.save();try{const l=-1!==o.gridRow?o.grid:null,h=o.cell.value,u=m.getTag("alphabet"),f=50;n=A(l,t,e,n),t.beginPath(),t.rect(e+this.padding,s+this.padding,n-this.padding-1,i-2*this.padding),t.clip(),t.font="12px monospace",t.textBaseline="top";const w=m.getTag(r.TAGS.UNITS),v=m.getTag("aligned"),M=(0,y.py)(u),T=m.getTag("separator")??"",x=n/5,N=b.Cn.getOrCreate(m).getSplitter(x),L=g["reference-sequence"],I=g["current-word"],_=N(null!=L&&""!=L?L:I??""),R=N(h);let O=S,k=d.classic;v&&v.includes("MSA")&&w==y.r2.SEPARATOR&&(k=d.MSA);for(const[r,l]of a().enumerate(R)){O=M.get(r),t.fillStyle=S;const a=l===R.length-1;if(p(e+this.padding,s,n,i,t,r,O,0,!0,1,T,a,k,E,l,o,_,c,C._monomerLengthMap),f>n)break}}catch(t){const e=t instanceof Error?t.message:t?t.toString():"Error 'undefined'";Re.logger.error(`Bio: MacromoleculeSequenceCellRenderer.render() error: ${e}`)}finally{t.restore()}}}class x extends r.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return C.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,n,i,o,a){const h=o.grid,c=o.cell,u=o.tableColumn,m=c.value??"",d=u.tags.separator,p=u.tags[r.TAGS.UNITS];n=A(h,t,e,n);const[g,f]=m.split("#"),y=(0,l.vU)(p,d);N(t,e,s,n,i,y(g),y(f),p)}}function N(t,e,s,n,i,r,o,l,h,c){if(r.length!==o.length){const t=function(t,e){let s=0,n=0;const i=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)i[t]===r[t]&&s++;const o=i.length-r.length;for(let t=i.length-1;t>o;t--)i[t]===r[t-o]&&n++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>n?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(a()(r).toArray(),a()(o).toArray());r=t.subParts1,o=t.subParts2}const u=t.measureText(T(r).join("")),m=t.measureText(T(o).join("")),d=Math.max(u.width,m.width);h&&(n=d+4*r.length,t.canvas.width=d+4*r.length);let g=Math.max(e,e+(n-(d+4*r.length))/2)+5;const f=Math.max(s,s+(i-28)/2);t.save(),t.beginPath(),t.rect(e,s,h?d+4*r.length:n,i),t.clip(),t.font="12px monospace",t.textBaseline="top";let b=w.UE.Color;"HELM"!=l&&(b=(0,y.py)(l.substring(l.length-2)));for(let e=0;e<r.length;e++){const s=r[e],a=o[e],l=b.get(s);if(s!=a){const r=b.get(a),o=p(g,f-7,n,i,t,s,l,0,!0),h=p(g,f+7,n,i,t,a,r,0,!0);g=Math.max(h,o),c&&(c[e]=L(s,a,l,r,f,7,i))}else g=p(g,f,n,i,t,s,l,0,!0,.5);g+=4}t.restore()}function L(t,e,s,n,i,r,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const h=l.measureText(T([t]).join("")).width,c=l.measureText(T([e]).join("")).width,u=Math.max(h,c);return a.height=o,a.width=u+4,l.font="12px monospace",l.textBaseline="top",p(0,i-r,u,o,l,t,s,0,!0),p(0,i+r,u,o,l,e,n,0,!0),a}var I,_=s(701),R=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(I||(I={})),new class{constructor(){this.regionTypes=[I.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.positionWidth=16,this.positionHeight=R.ES.Entropy}};var O=s(833);const k=I;var P,G;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(P||(P={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.positionWidth="positionWidth",t.positionHeight="positionHeight"}(G||(G={}));class F extends r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.skipEmptyPositions=this.bool(G.skipEmptyPositions,!1,{category:P.DATA}),this.regionTypes=this.stringList(G.regionTypes,[k.CDR],{category:P.DATA,choices:Object.values(k).filter((t=>t!=k.Unknown))}),this.chains=this.stringList(G.chains,["Heavy","Light"],{category:P.DATA,choices:["Heavy","Light"]}),this.positionWidth=this.float(G.positionWidth,16,{category:P.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position. A value of zero means autofit to the width."}),this.positionHeight=this.string(G.positionHeight,R.ES.Entropy,{category:P.LAYOUT,choices:Object.keys(R.ES)})}async init(){this.subs.push((0,_.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){if(this.setDataInProgress)return;const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}onTableAttached(){super.onTableAttached(),this.setData(this.dataFrame,this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case G.regionTypes:case G.chains:this.setData(this.dataFrame,this.regions)}switch(t.name){case G.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[O.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case G.positionWidth:this.calcSize();break;case G.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[O.bo.positionWidth]:this.positionWidth});this.calcSize();break;default:this.setData(this.dataFrame,this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){this.setDataInProgress||(this.setDataInProgress=!0,Re.logger.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.regions=e,this.dataFrame.dart!==t.dart&&(this.dataFrame=t)})).then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)})).catch((t=>{const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),Re.logger.error(e,void 0,s)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(t){Re.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&i.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Re.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),n=[];for(let t=0;t<s.length;t++)for(const i of this.chains){const r=e.find((e=>e.order==s[t]&&e.chain==i));n.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,i,e]})())}const r=await Promise.all(n);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of r)this.logos[t][e]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=i.table(this.chains,(t=>[...s.length>0?[i.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",i.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=i.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",i.tooltip.bind(this.filterSourceInput.input,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=i.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Re.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){Re.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let s=0;s<this.logos.length;s++){for(const e of this.chains)this.logos[s][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[s][t].Length)))}if(0===this.positionWidth){if(this.logos.length>0&&e>0){const t=22,s=13,n=9,i=(this.root.clientWidth-t-(this.logos.length-1)*n-s)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const s=this.logos[t][e];s.setOptions({[O.bo.positionWidth]:i}),s.root.style.width=i*s.Length+"px"}}}else for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[O.bo.positionWidth]:this.positionWidth});0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?R.Ct.Selected:R.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let s=0;s<this.chains.length;s++){const n=this.chains[s];this.logos[e][n].setOptions({[O.bo.filterSource]:t})}}}var W=s(9017),V=s(7656),H=s(7983),D=s(489);async function B(t){const e=b.Cn.getOrCreate(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let s=D.U.LEVENSHTEIN,n=t.seqCol.toList();if(e.isSeparator()){const t=e.convert(y.r2.FASTA);n=t.toList(),s=b.Cn.getOrCreate(t).getDistanceFunctionName()}else s=e.getDistanceFunctionName();for(let e=0;e<n.length;e++)n[e]=t.seqCol.isNone(e)?null:n[e];const i=await(0,V.I)(n,t.methodName,s,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,i.embedding[e])));return{distance:i.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,H.HV)(t.seqCol,!1),await n.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function U(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var Z=s(5697),Y=s(3379),z=s.n(Y),q=s(7795),X=s.n(q),K=s(569),$=s.n(K),j=s(3565),J=s.n(j),Q=s(9216),tt=s.n(Q),et=s(4589),st=s.n(et),nt=s(9414),it={};it.styleTagTransform=st(),it.setAttributes=J(),it.insert=$().bind(null,"head"),it.domAPI=X(),it.insertStyleElement=tt(),z()(nt.Z,it),nt.Z&&nt.Z.locals&&nt.Z.locals;var rt=s(3914),ot=s(6254);let at=0;const lt="cliffsDf",ht=new _.Subject,ct="act_diff",ut="sali",mt="sim",dt="line_index",pt=["1_seq","2_seq"],gt="filterCliffs";function ft(t,e,s){const n=e.getBoundingClientRect(),i=t.clientX-n.left,r=t.clientY-n.top;let o=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-i,t.a[1]-r)+Math.hypot(t.b[0]-i,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var yt=s(1040);async function wt(t,e,s,i,o){e.version!==e.temp["last-invalidated-version"]&&await(0,H.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(i).init((t=>e.temp["monomeric-mols"].get(t))),await n.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:i,simArr:o})}function bt(t){const e=i.divH([]),s=i.divV([i.divText(t.seqCol.name),i.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,n)=>{const r=i.divText(t.activityCol.get(s).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(i.divV([i.divText(t.seqCol.get(s)),r]))})),e}function vt(t){const e=i.div();e.append(i.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),n=new Array(2);t.line.mols.forEach(((e,i)=>{s[i]=t.seqCol.get(e),n[i]=t.activityCol.get(e)}));const r={},o=b.Cn.getOrCreate(t.seqCol),a=o.getSplitter(),l=St(a(s[0]),a(s[1]),o.units,r);return e.append(i.div(l,{style:{width:"300px",overflow:"scroll"}})),e.append(Mt(r)),e.append(Ct("Activity delta",Math.abs(n[0]-n[1]))),e.append(Ct("Cliff",t.sali)),e}function Ct(t,e){return i.divH([i.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),i.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function St(t,e,s,n){const i=document.createElement("canvas"),r=i.getContext("2d");return i.height=30,N(r,0,0,0,30,t,e,s,!0,n),i}function Mt(t){const e=i.div();if(Object.keys(t).length>0){const s=i.divV([]);s.append(i.divH([i.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),i.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(i.divH([i.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function At(t,e){const s=r.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const n=t.plot.grid();return n.col(e[0]).visible=!1,n.col(e[1]).visible=!1,n}s(7861);var Tt=s(4004),Et=s(7228),xt=s(8601),Nt=s(5226);s(9133);class Lt extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",Z.kg[0],{choices:Z.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((async t=>await this.render())));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((async e=>await this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((async t=>await this.render(!1)))),this.subs.push(r.debounce(i.onSizeChanged(this.root),50).subscribe((async t=>await this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}await this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}async render(t=!0){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(n.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var It=s(7241),_t=s(4293),Rt=s(2669);async function Ot(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=b.Cn.getOrCreate(t).getDistanceFunctionName(),n=new Rt.m(!0,!1),i=await n.calc(e,s);return n.terminate(),i}function kt(t){return(e,s)=>{const n=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?n(e,s):n(s,e)}}class Pt extends Lt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new _.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async render(t=!0){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=b.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const i=s.plot.grid();i.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));i.cell("score",o).cell.value=null,n.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,_t.Y)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,It.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await n.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Ot(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const n=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const i=b.Cn.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),n.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(n.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const r=Math.floor(s*n.length/o),u=s===a.length-1?Math.floor((s+1)*n.length/o):n.length;return new Promise(((s,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:n,max:i}})=>{t?o(t):(h=Math.min(h,n),c=Math.max(c,i),l.set(e,r),s())},t.postMessage({fnName:i,values:n,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,n=kt(e),i=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[n(this.targetMoleculeIdx,s)]:1-t[s]})));i.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=i.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=i.div(),s={},r=this.molCol?.name,o=t.col(r),a=b.Cn.getOrCreate(o),l=a.getSplitter(),h=l(this.moleculeColumn.get(this.targetMoleculeIdx)),c=l(t.get(r,t.currentRowIdx)),u=St(h,c,a.units,s);e.append(i.div(u,{style:{width:"300px",overflow:"scroll"}})),h.length!==c.length&&e.append(i.divV([i.divText("Different sequence length:",{style:{fontWeight:"bold"}}),i.divText(`target: ${h.length} monomers`),i.divText(`selected: ${c.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(Mt(s));const m=i.accordion(),d=i.element("i");d.className="grok-icon svg-icon svg-view-layout",m.addTitle(i.span([d,i.label("Similarity search")])),m.addPane("Differences",(()=>e),!0),n.shell.o=m.root}}var Gt=s(8518);class Ft extends Lt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new _.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async render(t=!0){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=b.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const n=r.DataFrame.fromColumns([s]);n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]})),(0,_t.Y)(this.root,n.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,It.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await n.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Ot(this.moleculeColumn),e=this.moleculeColumn.length,s=kt(e);this.renderMolIds=(0,Gt.L)(e,Math.min(e,this.limit),((e,n)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(n)?0:t[s(e,n)]))}}var Wt=s(9943),Vt=s(4413),Ht=s(1061),Dt=s(1345),Bt=s(116);const Ut={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class Zt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=i.inputs([]),this.methodsParams={[Bt.AL.UMAP]:new Bt.bD,[Bt.AL.T_SNE]:new Bt.aP},this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=i.columnInput(Ut[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=i.choiceInput("Method",Bt.AL.UMAP,[Bt.AL.UMAP,Bt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=i.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):i.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=i.inputs([]);let e=!1;this.similarityMetricInput=i.choiceInput("Similarity",yt.gk.Tanimoto,Z.Rt)}createAlgorithmSettingsDiv(t,e){return i.empty(t),Object.keys(e).forEach((s=>{const n=e[s],r=i.floatInput(n.uiName,n.value,(()=>{n.value=r.value}));i.tooltip.bind(r.root,n.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=i.columnInput(Ut[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),i.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Yt extends Zt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=i.boolInput("Plot Embeddings",!0),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class zt extends Zt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=i.intInput("Similarity cutoff",80),i.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),i.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var qt,Xt=s(8457);async function Kt(t,e,s,n){const i=(0,Xt.O)(e),o=(0,l.vU)(e.getTag(r.TAGS.UNITS),e.getTag("separator"))(s),a=n===qt.IDENTITY?function(t,e){const s=e.columns.length,n=new Array(s),i=new Array(s),o=new Array(s);for(let r=0;r<s;++r){const s=e.columns.byIndex(r);n[r]=s.getRawData(),i[r]=s.categories.indexOf(""),o[r]=s.categories.indexOf(t[r]??"")}const a=r.Column.float("Identity",e.rowCount),l=a.getRawData();for(let s=0;s<e.rowCount;++s){l[s]=0;for(let e=0;e<t.length;++e)n[e][s]===o[e]&&++l[s];l[s]/=t.length}return a}(o,i):n===qt.SIMILARITY?await async function(t,e){const s=e.columns.toList();return await(0,Et.Qx)(s,t)}(o,i):null;if(null===a)throw new Error(`In bio library: Unkown sequence scoring method: ${n}`);return a.name=t.columns.getUnusedName(a.name),t.columns.add(a),a}!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(qt||(qt={}));var $t,jt=function(t,e,s,n){return new(s||(s=Promise))((function(i,r){function o(t){try{l(n.next(t))}catch(t){r(t)}}function a(t){try{l(n.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?i(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((n=n.apply(t,e||[])).next())}))};class Jt{constructor(t,e,s=!1,n){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._stopStartBtn=i.button(i.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=i.button(i.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=i.button(i.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._closeBtn=i.button(i.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==n?void 0:n.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Jt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=i.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(i.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=i.iconFA("clock");this._isAutomatic||0===e&&(s=i.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const n=i.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=i.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=i.divH([s,n],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,s;n.shell.windows.showContextPanel=!0,n.shell.windows.showHelp=!1;const i=Array.from(n.shell.dockManager.rootNode.children)[0];this._node=n.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,i,""),(null===(e=null===(t=i.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=i.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return jt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],n=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];n.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,n,a),yield(0,Ht.gw)(a));const l=i.iconFA("check");if(n.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=i.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return jt(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return jt(this,void 0,void 0,(function*(){const n=i.div([],"demo-script-countdown");e.classList.add("hidden");let r=s/1e3;const o=this._createSVGIndicator(r);n.append(o),t.prepend(n);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),n.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){n.shell.dockManager.close(this._node),n.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){n.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Jt.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return jt(this,void 0,void 0,(function*(){this._initRoot(),n.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function Qt(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),Re.logger.error(t.message,void 0,s)}Jt.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}($t||($t={}));const te="data/sample_FASTA_PT_activity.csv";var ee=s(1811);async function se(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function ne(){return await n.functions.call("Dendrogram:getDendrogramService",{})}const ie="data/sample_FASTA_PT_activity.csv",re="sequence";var oe=s(3336),ae=s.n(oe);const le="data/sample_FASTA_PT_activity.csv";var he=s(8341);const ce="samples/HELM.csv";var ue=s(2568),me=s(525);class de{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.df=t,await this.buildView()}async buildView(){const t=a()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=n.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Re.name}.${this.funcName}?${t}`;const e={sequenceColumnName:"sequence"};for(const[t,s]of this.urlParams.entries())switch(t){case O.bo.fixWidth:case O.bo.fitArea:e[t]=["1","on","true"].includes(s.toLowerCase());break;default:e[t]=s}const s=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class pe{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=i.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=i.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=i.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var ge=s(9416);class fe{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const ye=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},we={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class be{constructor(t){this.gridCol=t,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.gridCol.grid.dart||t.gridColumn.dart!=this.gridCol.dart||!t.tableColumn||!t.isTableCell)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new fe(Oe().getBioLib()).getCappedRotatedMonomer(a,o),h=i.div(o),c=l?n.chem.svgMol(l,void 0,void 0,we):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return i.tooltip.show(i.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){let e=t.temp[ye.tooltipHandlerTemp];return e||(e=t.temp[ye.tooltipHandlerTemp]=new be(t)),e}}class ve extends r.GridCellRenderer{get name(){return C.Of.MONOMER}get cellType(){return C.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,n,i,r,o){if(r.gridRow<0)return;be.getOrCreate(r.gridColumn),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,y.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,y.GU)(l,6),e+n/2,s+i/2,n)}}class Ce extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new _.Subject}}class Se extends r.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(t){this._properties=t}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),this.logger.error(e,void 0,s)}}class Me extends r.Widget{constructor(t){super(i.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=i.intInput("Max monomer length",Re.properties.MaxMonomerLength,(t=>{Re.properties.MaxMonomerLength=t})),e=i.boolInput("Tooltip WebLogo",Re.properties.TooltipWebLogo,(t=>{Re.properties.TooltipWebLogo=t})),s=i.choiceInput("Default Separator",Re.properties.DefaultSeparator,[".","/","-"],(t=>{Re.properties.DefaultSeparator=t}));this.root.appendChild(i.form([t,e,s]))}}var Ae=s(5362),Te={};Te.styleTagTransform=st(),Te.setAttributes=J(),Te.insert=$().bind(null,"head"),Te.domAPI=X(),Te.insertStyleElement=tt(),z()(Ae.Z,Te),Ae.Z&&Ae.Z.locals&&Ae.Z.locals;class Ee extends r.Widget{constructor(t){super(i.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=b.Cn.getOrCreate(this.seqCol),e=Re.properties.TooltipWebLogo,s=this.seqCol.getTag(R.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}function xe(t,e,s,n){const i=b.Cn.getOrCreate(t);let r=null,o=null;for(let t=0;t<i.posList.length;++t)i.posList[t]==e&&(r=t),i.posList[t]==s&&(o=t);if(null===r&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===o&&null!==s)throw new Error(`End position ${s} not found.`);if(i.posList.length<o)throw new Error(`End position ${o} exceeds positions length`);const a=n||`${t.name}: (${e??""}-${s??""})`;return i.getRegion(r,o,a)}const Ne=["1","1A","1C","2","4","4A","4B","5","6"].join(y.CI),Le=[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}];class Ie{constructor(t,e){this.urlParams=t,this.funcName=e}async init(){this.df=r.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1");const t=this.df.getCol("seq");t.setTag(".positionNames",Ne),t.setTag(".regions",JSON.stringify(Le)),await this.buildView()}async buildView(){this.view=n.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Re.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo");this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class _e{constructor(t){this.call=t,this.inputs=new class{},this.fixRegion=!1;const e=t=>this.call.inputParams[t].property.description;this.inputs.table=i.tableInput("Table",this.call.inputParams.table.value??n.shell.tv.dataFrame,void 0,(()=>{}));const s=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),o={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.inputs.sequence=i.columnInput("Sequence",n.shell.tv.dataFrame,s,this.sequenceInputChanged.bind(this),o),this.inputs.start=i.choiceInput("Start",void 0,[],this.startInputChanged.bind(this)),this.inputs.end=i.choiceInput("End",void 0,[],this.endInputChanged.bind(this)),this.inputs.region=i.choiceInput("Region",null,[],this.regionInputChanged.bind(this)),this.inputs.name=i.stringInput("Name","",(()=>{}),{placeholder:this.getDefaultName()});for(const t in this.call.inputParams)i.tooltip.bind(this.inputs[t].captionLabel,e(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&b.Cn.getOrCreate(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInputPlaceholder()}regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=b.Cn.getOrCreate(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInputPlaceholder()}endInputChanged(){this.updateRegion(!1),this.updateNameInputPlaceholder()}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?b.Cn.getOrCreate(t):null,s=this.inputs.start.input,n=this.inputs.end.input;for(let t=s.options.length-1;t>=0;--t)s.options.remove(t);for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),i=document.createElement("option");e.text=i.text=t,e.value=i.value=t,s.options.add(e),n.options.add(i)}s.value=e?.posList[0]??"",n.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(".regions"):null,s=e?JSON.parse(e):null,n=this.inputs.region.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);const i=document.createElement("option");if(i.text="",i.value=JSON.stringify(null),n.options.add(i),null!=s){this.inputs.region.root.style.removeProperty("display");for(const t of s){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),n.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",s=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let n=t.options.length-1;n>=0;--n){const i=t.options[n],r=JSON.parse(i.value);r&&e===r.start&&s===r.end&&(t.selectedIndex=n)}}}updateNameInputPlaceholder(){this.inputs.name.input.attributes.placeholder.value=this.getDefaultName()}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,s=this.inputs.sequence.value,n=this.inputs.start.stringValue??"",i=this.inputs.end.stringValue??"";return null!=e?`${s.name}(${e.name}): ${e.start}-${e.end}`:`${s?.name}: (${n}-${i})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()??this.getDefaultName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=i.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});i.dialog({title:"Get Region"}).add(t).onOK((async()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Re.handleErrorUI(t)}))})).show()}widget(){const t=i.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=i.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Re.handleErrorUI(t)}))}));return r.Widget.fromRoot(i.divV([t,i.div(e)]))}}const Re=new Se;function Oe(){return Dt.NT.instance}let ke=null;class Pe{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function Ge(){let t;await Promise.all([(async()=>{await Dt.NT.instance.loadLibraries()})(),(async()=>{t=await n.functions.call("Chem:getRdKitModule")})(),(async()=>{const t=await Re.getProperties(),e=new Ce(t);Re.properties=e})()]).finally((()=>{Re.completeInit()}));const e=Dt.NT.instance.getBioLib(),s=[],i=[],r=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((e=>{s.push(e);const n=r[e].replaceAll("#R","O "),o=t.get_mol(n),a=JSON.parse(o.get_descriptors()).CrippenClogP;i.push(a),o?.delete()}));const o=i.reduce(((t,e)=>t+e),0)/i.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=i[t]<o?"#4682B4":"#DC143C";ke=new Pe(a)}function Fe(t){const e=new Ee(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();n.shell.error(e)})),e}function We(){return Dt.NT.instance.getBioLib()}function Ve(t){const e="getRegionTopMenu",s=r.Func.find({package:Re.name,name:e});if(1!==s.length)throw new Error(`Package '${Re.name}' func '${e}' not found`);const n=s[0].prepare({table:t.dataFrame,sequence:t});return new _e(n).widget()}async function He(t){return(0,Dt.cf)()}function De(t){try{new _e(t).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(`Get region editor error: ${e}`),Re.logger.error(e,void 0,s)}}function Be(t){const e=new pe;i.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function Ue(t){const e=new Yt(r.SEMTYPE.MACROMOLECULE);i.dialog({title:"Sequence Space"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function Ze(t){const e=new zt(r.SEMTYPE.MACROMOLECULE);i.dialog({title:"Activity Cliffs"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function Ye(t){const e=new Me(t);return e.init().then(),e}function ze(){return new E}function qe(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===r.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=i.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:g.short,[g.short,g.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const n=i.intInput("Max monomer length",t.temp[".mm.cellRenderer.maxMonomerLength"]??Re.properties.MaxMonomerLength,(e=>{t.temp[".mm.cellRenderer.maxMonomerLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));n.setTooltip(`The max length of monomer name displayed without shortening in '${g.short}' monomer width mode.`);const o=i.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));o.setTooltip("The size of margin between monomers (in pixels)");const a=i.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));a.setTooltip("Color code");const l=i.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const h=i.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip('When on, all sequences get rendered in the "diff" mode');const c=i.inputs([s,n,o,l,a,h]);return new r.Widget(c)}(t)}function Xe(t){return function(t){const e=i.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let n=w.UE.Color;switch(s){case"DNA":case"RNA":n=(0,y.py)("DNA");break;case"PT":n=(0,y.py)("PT")}const o=new Map;let l=0;const h=b.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),c=h.length;a()(h).filter((t=>!!t&&""!==t)).forEach((t=>{const e=o.get(t)||0;o.set(t,e+1),l=Math.max(l,e+1)})),l/=c;const u={},m=Array.from(o.entries());m.sort(((t,e)=>e[1]-t[1])),m.forEach((([t,e])=>{const s=e/c,r=n.get(t),o=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});o.style.width=s/l*50+"px";const a=i.div((100*s).toFixed(2)+"%");o.style.backgroundColor=r,u[t]=i.div([o,a],{classes:"macromolecule-cell-comp-analysis-value"})}));const d=i.tableFromMap(u);return Array.from(d.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(d),new r.Widget(e)}(t)}function Ke(){return new E}function $e(){return new x}function je(t,e,s,n,i){const r=new W.k(n,i,s,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunch()}function Je(){return new O.OZ}function Qe(){return new F}function ts(t,e,s,n){return xe(t,e??null,s??null,n??null)}function es(t,e,s,n,i){const o=xe(e,s??null,n??null,i??null);e.dataFrame.columns.add(o),o.setTag(r.TAGS.CELL_RENDERER,"sequence")}async function ss(t,e,o,a,l,h){if(!(0,ue.n)(e,"Activity Cliffs"))return;const c=U(t),u={units:e.getTag(r.TAGS.UNITS),aligned:e.getTag("aligned"),separator:e.getTag("separator"),alphabet:e.getTag("alphabet")},m=b.Cn.getOrCreate(e);let d=yt.gk.Tanimoto,p=e;if(m.isFasta()||m.isSeparator()&&m.alphabet&&"UN"!==m.alphabet)if(m.isFasta())d=m.getDistanceFunctionName();else{p=m.convert(y.r2.FASTA);const t=b.Cn.getOrCreate(p);d=t.getDistanceFunctionName(),u.units=y.r2.FASTA}const g=async()=>await async function(t,e,o,a,l,h,c,u,m,d,p,g,f,y,w,b,v,C){at++;const S=c/100,M=o??e;let A=!1,T=!1;const E={};let x,N;const L={seqCol:M,methodName:m,similarityMetric:u,embedAxesNames:a,options:v},{distance:I,coordinates:_}=await g(L);for(const e of _)t.columns.add(e);let R=I;const O=Object.values(D.U).map((t=>t.toString())).includes(u);O&&!I&&(R=rt.H.calc(e.toList(),D.o[u]()).data);const k=function(t,e,s){const n=[],i=[],r=[],o=[],a=new Set;for(let l=0;l!=t.length;++l)for(let h=0;h!=t.length-l;++h){const c=t[l]?t[l].get(h):0;if(c>=e){r.push(l),o.push(l+h+1),a.add(l),a.add(l+h+1),n.push(c);const t=Math.abs(s.get(l)-s.get(l+h+1));i.push(1!=c?t/(1-c):1/0)}}return{simVals:n,saliVals:i,n1:r,n2:o,cliffsMolIds:a}}(await async function(t,e,s,n){const i=t.categories,o=t.getRawData(),a=r.Column.string("seq",t.length).init((t=>i[o[t]])),l=r.DataFrame.fromColumns([a]),h=t.length;let c=Array(h-1);return s&&e?function(t,e,s){const n=(0,ot.y)(t);for(let i=0;i<t-1;++i){const o=new Float32Array(t-i-1).fill(0);for(let s=i+1;s<t;++s){const t=n(i,s);o[s-i-1]=e[t]===r.FLOAT_NULL?0:(0,Z.Om)(e[t])}s[i]=r.Column.fromFloat32Array("similarity",o)}}(h,e,c):c=await n(h,t,l,"seq",c),c}(M,R,O,f),S,h),P=function(t,e,s,n,i,o){const a=new Array(t).fill(0);for(let t=0;t!=s.length;++t)e[t]!=1/0&&(o.get(s[t])>o.get(n[t])?a[s[t]]+=e[t]:a[n[t]]+=e[t]);return r.Column.fromList("double",`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,a)}(M.length,k.saliVals,k.n1,k.n2,a,h);t.columns.add(P);const G=function(t,e){const s="containsCliff",n=t.columns.names().filter((t=>t.includes(s))).length+1,i=`${s}_${n}`;return r.Column.bool(i,t.rowCount).init((t=>e.has(t)))}(t,k.cliffsMolIds);t.columns.add(G);const F=function(t){const e=t.filter((t=>t!==1/0)),s=Math.min(...e);return{max:Math.max(...e),min:s}}(k.saliVals),W=.8/(F.max-F.min),V=n.shell.getTableView(t.name);V.grid.columns.byName(G.name).visible=!1;const H=V.addViewer(r.VIEWER.SCATTER_PLOT,{xColumnName:a[0],yColumnName:a[1],size:P.name,color:h.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:l}),B=H.getInfo().canvas,U=function(t,e,s,n,i){const o=new Array(t.n1.length).fill(null);for(let e=0;e<t.n1.length;e++){const s=t.n1[e],n=t.n2[e];o[e]={id:e,mols:[s,n],selected:!1,a:[],b:[]}}const a=r.DataFrame.create(o.length);return pt.forEach(((t,s)=>{a.columns.addNewString(t).init((t=>e.get(o[t].mols[s]))),function(t,e){Object.keys(e).forEach((s=>{t.tags[s]=e[s]}))}(a.col(t),i),a.col(t).semType=n})),a.columns.addNewFloat(ct).init((t=>Math.abs(s.get(o[t].mols[0])-s.get(o[t].mols[1])))),a.columns.addNewInt(dt).init((t=>t)),a.columns.addNewFloat(ut).init((e=>t.saliVals[e])),a.columns.addNewFloat(mt).init((e=>t.simVals[e])),a.name=`${lt}${at}`,{lines:o,linesDf:a}}(k,e,h,d,p),Y=b?b(U.linesDf,pt).sort([ut],[!1]):U.linesDf.plot.grid().sort([ut],[!1]);t.temp[".cliffsDfGrid"]=Y;const z=i.button(`${U.linesDf.rowCount} cliffs`,(()=>{V.dockManager.dock(Y,"down",null,"Activity cliffs",C??.2)}));z.classList.add("scatter_plot_link","cliffs_grid"),H.root.append(z);const q=i.switchInput("Show only cliffs",!1,(()=>{q.value?(H.dataFrame.setTag(gt,G.name),t.rows.match({[G.name]:!0}).filter(),ht.next(G.name)):(H.dataFrame.setTag(gt,""),t.filter.setAll(!0,!0),ht.next(""))}));q.root.classList.add("scatter_plot_link","show_only_cliffs"),H.root.append(q.root),ht.subscribe((t=>{q.enabled=""===t||t===G.name}));const X=n.events.onViewerClosed.subscribe((t=>{t.args.viewer===H&&(V.dockManager.close(Y.root),X.unsubscribe(),V.subs=V.subs.filter((t=>t!==X)))}));return V.subs.push(X),U.linesDf.onCurrentCellChanged.subscribe((()=>{A=!0;const s=U.linesDf.currentCol&&U.linesDf.currentCol.name===pt[1]?1:0,r=-1!==U.linesDf.currentRowIdx?U.lines[U.linesDf.currentRowIdx]:null;H.dataFrame.currentRowIdx=r?r.mols[s]:-1,H.dataFrame.filter.set(0,!U.lines[0].selected),H.dataFrame.filter.set(0,U.lines[0].selected),r&&setTimeout((()=>{!function(t,e,s,r,o,a,l,h){const c=e.getPane("Cliff Details");i.empty(c.root);const u=h({cashedData:s,line:r,df:t,seqCol:o,activityCol:a,sali:l});c.root.append(u),setTimeout((()=>{n.shell.o=e.root}),500)}(t,x,E,r,e,h,U.linesDf.get(ut,r.id),w);const s=H.dataFrame.getSortedOrder(V.grid.sortByColumns,V.grid.sortTypes);V.grid.scrollToCell(e.name,s.indexOf(H.dataFrame.currentRowIdx))}),1e3)})),U.linesDf.onSelectionChanged.subscribe((e=>{if(!1===U.linesDf.selection.anyTrue)U.lines.forEach((t=>{t.selected=!1}));else if(-1!==U.linesDf.mouseOverRowIdx){const t=U.lines[U.linesDf.mouseOverRowIdx];t.selected=!t.selected}setTimeout((()=>{const e=r.BitSet.create(t.rowCount);U.lines.forEach((t=>{t.selected&&t.mols.forEach((s=>{e.set(s,t.selected,!0)}))})),t.selection.copyFrom(e),V.grid.invalidate()}),300)})),t.onSelectionChanged.subscribe((e=>{T?T=!1:!1===t.selection.anyTrue&&"number"==typeof e&&(U.lines.forEach((t=>{t.selected=!1})),Y.dataFrame.selection.setAll(!1,!1),Y.invalidate())})),B.addEventListener("mousemove",(function(n){clearTimeout(N),N=s.g.setTimeout((function(){const s=ft(n,B,U.lines);s&&-1===t.mouseOverRowIdx&&i.tooltip.show(y({cashedData:E,line:s,df:t,seqCol:e,activityCol:h}),n.clientX,n.clientY)}),500)})),B.addEventListener("mousedown",(function(e){T=!0;const s=ft(e,B,U.lines);if(s&&-1===t.mouseOverRowIdx){e.ctrlKey?(s.selected=!s.selected,U.linesDf.selection.set(s.id,s.selected)):U.linesDf.currentRowIdx!==s.id&&(U.linesDf.currentRowIdx=s.id,t.currentRowIdx=s.mols[0],t.filter.set(0,!U.lines[0].selected),t.filter.set(0,U.lines[0].selected));const n=U.linesDf.getSortedOrder(Y.sortByColumns,Y.sortTypes);Y.scrollToCell(pt[0],n.indexOf(s.id))}})),H.onEvent("d4-before-draw-scene").subscribe((e=>{const s=function(t,e,s,n,i,r,o){const a=n.lines,l=t.getInfo().canvas.getContext("2d"),h=t.dataFrame.columns.byName(e),c=t.dataFrame.columns.byName(s);for(let e=0;e<a.length;e++){const s=t.worldToScreen(h.get(a[e].mols[0]),c.get(a[e].mols[0])),u=t.worldToScreen(h.get(a[e].mols[1]),c.get(a[e].mols[1]));a[e].a=[s.x,s.y],a[e].b=[u.x,u.y];const m=new Path2D;m.moveTo(a[e].a[0],a[e].a[1]);const d=a[e].selected?"255,255,0":"0,128,0",p=i[e]===1/0?1:.2+(i[e]-o)*r;l.strokeStyle=`rgba(${d},${p})`,l.lineWidth=a[e].id===n.linesDf.currentRowIdx?3:1,m.lineTo(a[e].b[0],a[e].b[1]),l.stroke(m)}return a}(H,a[0],a[1],U,k.saliVals,W,F.min);if(A){const t=s[U.linesDf.currentRowIdx];setTimeout((()=>{const{zoomLeft:e,zoomRight:s,zoomTop:n,zoomBottom:i}=function(t,e,s,n,i,r){const o=Math.abs(s-i),a=Math.abs(n-r),l=t/o,h=e/a,c=Math.min(l,h),u=t/c*5,m=e/c*5,d=(s<i?s:i)+o/2-u/2,p=(n>r?n:r)-a/2+m/2;return{zoomLeft:d,zoomRight:d+u,zoomTop:p,zoomBottom:p-m}}(H.viewport.width,H.viewport.height,H.dataFrame.get(a[0],t.mols[0]),H.dataFrame.get(a[1],t.mols[0]),H.dataFrame.get(a[0],t.mols[1]),H.dataFrame.get(a[1],t.mols[1]));H.zoom(e,n,s,i)}),300),A=!1}q.value?t.rows.match({[G.name]:!0}).filter():!0===q.enabled&&t.filter.setAll(!0,!1)})),H.addProperty("similarityLimit","double",S),x=function(){const t=i.accordion(),e=i.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(i.span([e,i.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>i.divText("Cliff has not been selected")),!0),n.shell.o=t.root,t}(),H}(t,p,null,c,"Activity cliffs",o,a,d,l,r.SEMTYPE.MACROMOLECULE,u,B,wt,bt,vt,At,h),f=l===Bt.AL.UMAP?5e3:2e3;if(t.rowCount>2e4)n.shell.warning("Too many rows, maximum for sequence activity cliffs is 20000");else{if(!(t.rowCount>f))return await g();i.dialog().add(i.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),e=await g();return t.close(),e})).show()}}async function ns(t,e,s,o=yt.gk.Tanimoto,a,l){if(await(0,Ht.gw)(10),!(0,ue.n)(e,"Sequence space"))return;const h=U(t),c=r.DataFrame.fromColumns([e]).clone(),u=function(t,e){const s=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),n=[...e.getRawData()],i=[];let r=0;for(let e=0;e<t.rowCount;e++)s.includes(n[e])&&(t.rows.removeAt(e-r),i.push(e),r+=1);return i}(c,e),m={seqCol:c.col(e.name),methodName:s,similarityMetric:o,embedAxesNames:h,options:l},d=s===Bt.AL.UMAP?1e5:15e3,p=s===Bt.AL.UMAP?5e3:2e3;if(t.rowCount>d)n.shell.warning(`Too many rows, maximum for sequence space is ${d}`);else{if(!(t.rowCount>p))return g(await B(m));i.dialog().add(i.divText("Sequence space analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running Sequence space..."),e=await B(m);return t.close(),g(e)})).show()}function g(e){const s=e.coordinates;for(const e of s){const s=e.toList();u.forEach((t=>s.splice(t,0,null))),t.columns.add(r.Column.float(e.name,t.rowCount).init((t=>s[t])))}if(a)return n.shell.tableView(t.name).scatterPlot({x:h[0],y:h[1],title:"Sequence space"})}}async function is(t,e){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void n.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,ue.n)(e,"To Atomic Level"))return;const s=(await Oe()).getBioLib(),o=await(0,xt.i0)(t,e,s);null!==o.col&&(t.columns.add(o.col,!0),await n.data.detectSemanticTypes(t)),o.warnings&&o.warnings.length>0&&n.shell.warning(i.list(o.warnings))}function rs(){(0,me.K)()}async function os(t=null,e=null){return(0,me.K)({col:t,clustersCol:e})}async function as(){const t=n.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==r.SEMTYPE.MACROMOLECULE&&(b.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,ue.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});n.shell.tv.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let o=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),n=e.find((t=>b.Cn.getOrCreate(t).isMsa())),r=i.choiceInput("Column",n?n.name:t[0],t);i.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(i.div([r])).onOK((async()=>{const t=e.find((t=>t.name==r.value))??null;t&&await s(t)})).show()}else o=e[0];o&&await s(o)}else n.shell.error("Current table does not contain sequences")}async function ls(t){(0,Et.Xk)(t)}function hs(t){return new Nt.i(t).importFasta()}function cs(t){return console.log(t),[]}function us(){const t=(0,_t.B)()[0];(0,Tt.O)(t)}function ms(){return new ve}async function ds(t){const e=r.TaskBarProgressIndicator.create("Test detectMacromolecule..."),s=(await n.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let i=0;const o=[];for(const a of s)try{const e=await n.dapi.files.readAsText(t+a.fullPath),s=r.DataFrame.fromCsv(e);for(const t of s.columns)await n.functions.call("Bio:detectMacromolecule",{col:t})===r.SEMTYPE.MACROMOLECULE&&o.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(r.TAGS.UNITS)}`})}catch(t){o.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/s.length,`Test ${a.fileName}`)}n.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=r.DataFrame.fromObjects(o);return a.name=`datasets_detectMacromolecule_${t}`,a}async function ps(t,e){await(0,ge.n)(t,e)}function gs(t){const e=b.Cn.getOrCreate(t).stats;return Object.keys(e.freq)}function fs(){return new Pt}function ys(){const t=n.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function ws(){return new Ft}function bs(){const t=n.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function vs(t){const e=(0,_t.B)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new H.uH(e)}function Cs(t){n.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),n.shell.tv.grid.scrollToCell(t,0)}async function Ss(t,e,s){return Kt(t,e,s,qt.IDENTITY)}async function Ms(t,e,s){return Kt(t,e,s,qt.SIMILARITY)}function As(){(0,Wt.C2)()}function Ts(){return new Vt.ST}async function Es(){const t=r.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new de(t,"webLogoLargeApp"),s=await Re.files.readCsv("data/sample_PT_100000x5.csv");await n.data.detectSemanticTypes(s),await e.init(s)}finally{t.close()}}async function xs(){const t=r.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new Ie(t,"getRegionApp");await e.init()}finally{t.close()}}function Ns(t,e){!function(t,e){const s=b.Cn.getOrCreate(t.column),i=Object.values(y.r2).filter((t=>t!==s.units));e.group("Copy").items(i,(e=>{const s=b.Cn.getOrCreate(t.column),i=e===y.r2.SEPARATOR?Re.properties.DefaultSeparator:void 0,r=s.getConverter(e,i)(t.value);navigator.clipboard?(navigator.clipboard.writeText(r),n.shell.info(`Value of notation '${e}' copied to clipboard`)):n.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e)}async function Ls(){await async function(){let t,e;try{const s=new Jt("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await s.step("Load DNA sequences",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,e=await Re.files.readCsv(te),t=n.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const s=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(s,r.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const s=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){Qt(t)}}()}async function Is(){await async function(){let t,e,s,i,o;try{const a=new Jt("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[i,t,e]=await Promise.all([Re.files.readCsv(ie),se(),ne()]),s=n.shell.addTableView(i),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,s,n){let i;{const t=Object.values($t);for(let s=0;s<t.length;s++){const n=t[s];if(!e.col(n)){const i=s==t.length-1;e.columns.add(r.Column.float(n,e.rowCount),i)}}if(e.rowCount>=1){const n=e.getCol(s).toList(),i=Date.now();Re.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await(0,V.I)(n,"UMAP",yt.W.Levenshtein,{}),o=Date.now();Re.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-i)/1e3} s`);for(let s=0;s<t.length;s++){const n=t[s],i=e.getCol(n),o=r.embedding[s];i.init((t=>o[t]))}const a=Date.now();Re.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}i=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:$t.X,yColumnName:$t.Y,lassoTool:!0})}return t.dockManager.dock(i,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),i}(s,i,re)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const n=i.getCol(re).toList(),r=rt.H.calc(n,((t,e)=>ee.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{i.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=i.getCol("sequence_id");i.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),i.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){Qt(t)}}()}async function _s(){await async function(){let t,e,s,i,o;const a=Bt.AL.UMAP;try{const l=new Jt("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([Re.files.readCsv(le),se(),ne()]),i=n.shell.addTableView(s),i.grid.props.rowHeight=22,i.grid.columns.byName("cluster").visible=!1,i.grid.columns.byName("sequence").width=300,i.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await ss(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),i.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),ae()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const n=s.getCol("sequence").toList(),r=rt.H.calc(n,((t,e)=>ee.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(i.grid,o,void 0,150,void 0),i.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){Qt(t)}}()}async function Rs(){await async function(){const t="HELM";let e,s,o;try{await new Jt("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,e=await Re.files.readCsv("samples/HELM.csv"),s=n.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const n=s.grid.columns.byIndex(e);[t,"Activity"].includes(n.name)||(n.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await is(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const n=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(n),o=i.dialog().add(a).show(),await(0,Ht.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){Qt(t)}}()}async function Os(){await async function(){let t,e,s,i,o,a;const l="msa(HELM)",h=Bt.AL.UMAP;try{const c=new Jt("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=n.shell.addTableView(e=await Re.files.readCsv(ce)),n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=he.J[0];i=await(0,he.f)(s,l,t,1.53,0,void 0),e.columns.add(i),await n.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await ns(e,i,h,D.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){Qt(t)}}()}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>r});class n{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class i{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",n="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=r+s,n=this.seq2.substr((e-1)*this.step,this.step)+n):this.dpGrid[t][e].parentJ==e?(n=r+n,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:r+s,n=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+n:r+n);const i=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[i][e].parentJ}return new i(s,n,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let n=1;n<=this.len1;n++)for(let i=1;i<=this.len2;i++)this.fillOne(n,i),this.dpGrid[n][i].value<=0?(this.dpGrid[n][i].value=0,this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0):0==this.dpGrid[this.dpGrid[n][i].parentI][this.dpGrid[n][i].parentJ].value&&(this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0),this.dpGrid[n][i].value>t&&(t=this.dpGrid[n][i].value,e=n,s=i);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,n=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],this.BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]],this.NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]],this.PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]],this.PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]],this.PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]],this.TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]],this.CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23},this.CONNUCL={A:0,T:1,C:2,G:3},this.CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63},this.setMethod(n),this.setSequences(t,e),this.setGap(s)}}},7983:(t,e,s)=>{"use strict";s.d(e,{HV:()=>p,QF:()=>d,pf:()=>m,uH:()=>u});var n=s(4469),i=s(3870),r=s(976),o=s(7241),a=s(4293),l=s(1061),h=s(8447);const c="substr_helm";class u{constructor(t){this.col=t[0],this.createUI()}editHelmLinkAction(){(0,a.Y)(this.inputsDiv,this.grid.root),i.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(c,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const t=this.units===h.r2.HELM?i.divV([this.columnsInput,this.editHelmLink]):this.units===h.r2.SEPARATOR?i.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):i.inputs([this.columnsInput,this.substructureInput]);(0,a.Y)(this.inputsDiv,t)}updateNotationDiv(){this.units=this.col.getTag(r.TAGS.UNITS),this.separator=this.col.getTag("separator");const t=this.dialog.root.getElementsByClassName("notation-text")[0];t&&(t.textContent=`Notation: ${this.units}`)}createUI(){const t=n.shell.tv.dataFrame,e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.columnsInput=i.columnInput("Column",t,this.col,(t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()}),e),this.substructureInput=i.stringInput("Substructure",""),this.editHelmLink=i.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const s=r.DataFrame.create(1);s.columns.addNewString(c).init((t=>"")),s.col(c).semType=this.col.semType,s.col(c).setTag(r.TAGS.UNITS,h.r2.HELM),this.grid=s.plot.grid(),this.separatorInput=i.stringInput("Separator",this.separator),this.inputsDiv=i.div(),this.units=this.col.getTag(r.TAGS.UNITS),this.separator=this.col.getTag("separator"),this.updateInputs(),this.dialog=i.dialog("Substructure Search").add(i.divV([i.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,e=this.units===h.r2.HELM?s.get(c,0):this.substructureInput.value;this.units===h.r2.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(e=e.replaceAll(this.separatorInput.value,this.separator)),t=this.units===h.r2.HELM?await d(e,this.col):m(e,this.col),this.col.dataFrame.filter.and(t)})).show()}}function m(t,e,s){const n=s?function(t,e){const s=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),n=t.charAt(0)===e,i=t.charAt(t.length-1)===e,r=t.replace(new RegExp(`^${s}|${s}$`,"g"),"");return n?i?`${s}${r}${s}`:`${s}${r}${s}|${s}${r}$`:i?`^${r}${s}|${s}${r}${s}`:`^${r}${s}|${s}${r}${s}|${s}${r}$`}(t,s):t,i=r.BitSet.create(e.length);for(let s=0;s<e.length;s++){const r=e.get(s);(r.match(n)||r===t)&&i.set(s,!0,!1)}return i}async function d(t,e){e.version!==e.temp["last-invalidated-version"]&&await p(e,!0);const s=r.Column.string("helm",1).init((e=>t));s.semType=r.SEMTYPE.MACROMOLECULE,s.setTag(r.TAGS.UNITS,h.r2.HELM);const i=await(0,o.D)(s,!0,e.temp["monomers-dict"]);return(await n.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:i.get(0),molBlockFailover:""})).get(0)}async function p(t,e){const s=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);await(0,l.gw)(10);const n=new Map,i=await(0,o.D)(t,e,n);t.temp["monomeric-mols"]=i,t.temp["monomers-dict"]=n,t.temp["last-invalidated-version"]=t.version,s.close()}},2568:(t,e,s)=>{"use strict";s.d(e,{n:()=>o});var n=s(4469),i=s(976),r=s(499);function o(t,e,s=[],o=[],a=!0){const[l,h]=function(t,e,s=[],o=[]){let a=!0,l="";const h=r.Cn.getOrCreate(t);if(t.semType!==i.SEMTYPE.MACROMOLECULE)n.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const t=h.notation;if(s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!h.isHelm()){const t=h.alphabet;o.length>0&&!o.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(t,e,s,o);return a&&!l&&n.shell.warning(h),l}},3553:(t,e,s)=>{"use strict";s.d(e,{Of:()=>r,WY:()=>h,jB:()=>c,rs:()=>a});var n,i,r,o,a,l=s(8341);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(n||(n={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(i||(i={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(t){t.CELL_CHANGING="isCellChanging"}(o||(o={})),function(t){t.SEPARATOR="."}(a||(a={}));const h="3.3.1",c={pepsea:{gapOpen:1.53,gapExtend:0,method:l.J[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(t,e,s)=>{"use strict";s.d(e,{O:()=>m});var n=s(976),i=s(3870),r=s(4469),o=s(3336),a=s.n(o),l=s(8447),h=s(499);let c=null,u=[];function m(t){let e=t??r.shell.t.columns.bySemType("Macromolecule");if(!e)throw new Error("No column with Macromolecule semantic type found");let s=h.Cn.getOrCreate(e),o=s.notation;const m=i.divText("Current notation: "+o,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),d=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],p=i.columnInput("Column",r.shell.t,e,(t=>{t.semType===n.SEMTYPE.MACROMOLECULE?(e=t,s=h.Cn.getOrCreate(e),o=s.notation,o===l.r2.HELM&&(y.value="/"),m.textContent="Current notation: "+o,f=d.filter((t=>t!==o)),b=i.choiceInput("Convert to",f[0],f,w),w(),c?.clear(),c?.add(i.div([m,p.root,b.root,y.root]))):p.value=e})),g=["-",".","/"];let f=d.filter((t=>t!==o));const y=i.choiceInput("Separator",g[0],g),w=()=>{b.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let b=i.choiceInput("Convert to",f[0],f,w);w(),b.onChanged((()=>{w()})),null==c&&(c=i.dialog("Convert Sequence Notation").add(i.div([m,p.root,b.root,y.root])).onOK((async()=>{const t=b.value,s=y.value??void 0;await async function(t,e,s){const n=h.Cn.getOrCreate(t).convert(e,s);t.dataFrame.columns.add(n);const i=await r.functions.call("Bio:detectMacromolecule",{col:n});return i&&(n.semType=i),await r.data.detectSemanticTypes(t.dataFrame),n}(e,t,s)})).show({x:350,y:100}),u.push(c.onClose.subscribe((t=>{u.forEach((t=>{t.unsubscribe()})),u=[],c=null}))))}},1345:(t,e,s)=>{"use strict";s.d(e,{NT:()=>w,cf:()=>f});var n=s(4469),i=s(3870),r=s(976),o=s(701),a=s(7228),l=s(4941);const h="Libraries",c="System:AppData/Bio/libraries/";async function u(){return await Promise.all((await n.dapi.files.list(c,!0,"")).map((async t=>t.fullPath.substring(c.length))))}let m=Promise.resolve();async function d(){let t;return m=m.then((async()=>{const e=await n.dapi.userDataStorage.getValue(h,"Settings",!0);t=e?JSON.parse(e):{exclude:[]},t.exclude=t.exclude instanceof Array?t.exclude:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await m,t}async function p(t){m=m.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),await n.dapi.userDataStorage.postValue(h,"Settings",JSON.stringify(t),!0)})),await m}async function g(){const t=i.dialog({title:"Manage files"}).add(i.fileBrowser({path:"System:AppData/Bio/libraries"}).root).addButton("OK",(()=>t.close())).show()}async function f(){const t=i.button("Manage",g),e=i.inputs([]),s=await u(),o=await d();for(const t of s){const s=i.boolInput(t,!o.exclude.includes(t),(()=>{1==s.value?o.exclude=o.exclude.filter((e=>e!=t)):o.exclude.includes(t)||o.exclude.push(t),p(o).then((async()=>{await w.instance.loadLibraries(!0),n.shell.info("Monomer library user settings saved.")}))}));e.append(s.root)}return new r.Widget(i.divV([e,i.div(t)]))}class y{constructor(t,e){this._monomers={},this._onChanged=new o.Subject,this._monomers=t,this.error=e}getMonomer(t,e){return t in this._monomers&&e in this._monomers[t]?this._monomers[t][e]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((s=>{e[s]=this._monomers[t][s].molfile})),e}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}get onChanged(){return this._onChanged}_updateInt(t){const e=t.getPolymerTypes(),s=this.getPolymerTypes();e.forEach((e=>{s.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((s=>{this._monomers[e][s]=t.getMonomer(e,s)}))}))}update(t){this._updateInt(t),this._onChanged.next()}updateLibs(t,e=!1){e&&(this._monomers={});for(const e of t)e.error||this._updateInt(e);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}}class w{constructor(){this._monomerLib=new y({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(t=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[e,s]=await Promise.all([u(),d()]),n=e.filter((t=>!s.exclude.includes(t))),i=await Promise.all(n.map((t=>this.readLibrary(c,t).catch((e=>{const s=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new y({},s)})))));this._monomerLib.updateLibs(i,t)}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;n.shell.warning(e);const s=t instanceof Error?t.stack:void 0;l._package.logger.error(e,void 0,s)}}))}async readLibrary(t,e){let s,i,o=[];const l=new r.FileSource(t);if(e.endsWith(".sdf"))1===r.Func.find({package:"Chem",name:"importSdf"}).length?(s=await l.readAsBytes(e),i=await n.functions.call("Chem:importSdf",{bytes:s}),o=(0,a.Xk)(i[0])):n.shell.warning("Chem package is not installed");else{const t=await l.readAsText(e);o=JSON.parse(t)}const h={},c=[];return o.forEach((t=>{c.includes(t.polymerType)||(h[t.polymerType]={},c.push(t.polymerType)),h[t.polymerType][t.symbol]=t})),new y(h)}static get instance(){return w._instance||(w._instance=new w),w._instance}}w._instance=null},525:(t,e,s)=>{"use strict";s.d(e,{K:()=>N});var n=s(4469),i=s(976),r=s(3870),o=s(8447),a=s(499),l=s(6098),h=s(8341),c=s(2568),u=s(3553),m=s(4941),d=s(3379),p=s.n(d),g=s(7795),f=s.n(g),y=s(569),w=s.n(y),b=s(3565),v=s.n(b),C=s(9216),S=s.n(C),M=s(4589),A=s.n(M),T=s(9564),E={};E.styleTagTransform=A(),E.setAttributes=v(),E.insert=w().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=S(),p()(T.Z,E),T.Z&&T.Z.locals&&T.Z.locals;class x extends Error{constructor(t,e){super(t,e)}}async function N(t={}){return new Promise((async(e,s)=>{var o,a,l;t.clustersCol??(t.clustersCol=null),t.pepsea??(t.pepsea={}),(o=t.pepsea).method??(o.method=u.jB.pepsea.method),(a=t.pepsea).gapOpen??(a.gapOpen=u.jB.pepsea.gapOpen),(l=t.pepsea).gapExtend??(l.gapExtend=u.jB.pepsea.gapExtend);const c=t.col?.dataFrame??n.shell.t,m=t.col??c.columns.bySemType(i.SEMTYPE.MACROMOLECULE);if(null==m){const t="MSAError: dataset doesn't conain any Macromolecule column";n.shell.warning(t),s(new x(t))}const d=r.choiceInput("Method",t.pepsea.method,h.J);d.setTooltip("Alignment method");const p=r.floatInput("Terminal gap",t?.kalign?.terminalGap??null);p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=r.p(`Kalign version: ${u.WY}`,"kalign-version"),f=r.floatInput("Gap open",t.pepsea.gapOpen);f.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.floatInput("Gap extend",t.pepsea.gapExtend);y.setTooltip("Gap extension penalty to skip the alignment");const w=r.inputs([f,y,p]),b=r.button("Alignment parameters",(()=>{w.hidden=!w.hidden}),"Adjust alignment parameters such as penalties for opening and extending gaps");b.classList.add("msa-params-button"),w.hidden=!0,b.prepend(r.icons.settings((()=>null)));const v=[d.root.style],C=[p.root.style,g.style];let S;const M=r.columnInput("Sequence",c,m,(async()=>{S=await I(M.value,c,v,C,d,A,f,y,p)}),{filter:t=>t.semType===i.SEMTYPE.MACROMOLECULE});M.setTooltip("Sequences column to use for alignment");const A=r.columnInput("Clusters",c,t.clustersCol);if(A.nullable=!0,M.fireChanged(),t.col)return S=await I(t.col,c,v,C,d,A,f,y,p),void await L(M,c,S,e,s);r.dialog("MSA").add(M).add(A).add(d).add(w).add(b).add(g).onOK((async()=>{await L(M,c,S,e,s)})).show()}))}async function L(t,e,s,r,o){let a=null;const l=i.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(t.fireChanged(),t.value.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===s)throw new Error("Invalid column format");if(a=await s(),null==a)return o("PepSeA container has not started");e.columns.add(a),await n.data.detectSemanticTypes(e),r(a)}catch(t){const e=t instanceof Error?t.message:t.toString();n.shell.error(e),o(t)}finally{l.close()}}async function I(t,e,s,r,d,p,g,f,y){try{if(t.semType!==i.SEMTYPE.MACROMOLECULE)return;const n=e.columns.getUnusedName(`msa(${t.name})`);if((0,c.n)(t,t.name,[o.r2.FASTA,o.r2.SEPARATOR],["DNA","RNA","PT"],!1)){_(s,r,"kalign"),g.value=null,f.value=null,y.value=null;const e=a.Cn.getOrCreate(t),i=e.isFasta()?t:e.convert(o.r2.FASTA);return async()=>await(0,l.U)(i,!1,n,p.value)}if((0,c.n)(t,t.name,[o.r2.HELM],[],!1))return _(s,r,"pepsea"),g.value??(g.value=u.jB.pepsea.gapOpen),f.value??(f.value=u.jB.pepsea.gapExtend),async()=>await(0,h.f)(t,n,d.value,g.value,f.value,p.value);if((0,c.n)(t,t.name,[o.r2.SEPARATOR],["UN"],!1)){const e=a.Cn.getOrCreate(t).convert(o.r2.HELM);return _(s,r,"pepsea"),g.value??(g.value=u.jB.pepsea.gapOpen),f.value??(f.value=u.jB.pepsea.gapExtend),async()=>await(0,h.f)(e,n,d.value,g.value,f.value,p.value)}return g.value=null,f.value=null,y.value=null,void _(s,r,"kalign")}catch(t){const e=t instanceof Error?t.message:t.toString();n.shell.error(e),m._package.logger.error(e)}}function _(t,e,s){if("kalign"===s){for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}else{for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}}},6098:(t,e,s)=>{"use strict";s.d(e,{U:()=>k});var n=s(976),i=s(5226);const r=Symbol("Comlink.proxy"),o=Symbol("Comlink.endpoint"),a=Symbol("Comlink.releaseProxy"),l=Symbol("Comlink.thrown"),h=t=>"object"==typeof t&&null!==t||"function"==typeof t,c=new Map([["proxy",{canHandle:t=>h(t)&&t[r],serialize(t){const{port1:e,port2:s}=new MessageChannel;return u(t,e),[s,[s]]},deserialize:t=>(t.start(),d(t))}],["throw",{canHandle:t=>h(t)&&l in t,serialize({value:t}){let e;return e=t instanceof Error?{isError:!0,value:{message:t.message,name:t.name,stack:t.stack}}:{isError:!1,value:t},[e,[]]},deserialize(t){throw t.isError?Object.assign(new Error(t.value.message),t.value):t.value}}]]);function u(t,e=self){e.addEventListener("message",(function s(n){if(!n||!n.data)return;const{id:i,type:o,path:a}=Object.assign({path:[]},n.data),h=(n.data.argumentList||[]).map(v);let c;try{const e=a.slice(0,-1).reduce(((t,e)=>t[e]),t),s=a.reduce(((t,e)=>t[e]),t);switch(o){case"GET":c=s;break;case"SET":e[a.slice(-1)[0]]=v(n.data.value),c=!0;break;case"APPLY":c=s.apply(e,h);break;case"CONSTRUCT":c=function(t){return Object.assign(t,{[r]:!0})}(new s(...h));break;case"ENDPOINT":{const{port1:e,port2:s}=new MessageChannel;u(t,s),c=function(t,e){return w.set(t,e),t}(e,[e])}break;case"RELEASE":c=void 0;break;default:return}}catch(t){c={value:t,[l]:0}}Promise.resolve(c).catch((t=>({value:t,[l]:0}))).then((t=>{const[n,r]=b(t);e.postMessage(Object.assign(Object.assign({},n),{id:i}),r),"RELEASE"===o&&(e.removeEventListener("message",s),m(e))}))})),e.start&&e.start()}function m(t){(function(t){return"MessagePort"===t.constructor.name})(t)&&t.close()}function d(t,e){return g(t,[],e)}function p(t){if(t)throw new Error("Proxy has been released and is not useable")}function g(t,e=[],s=function(){}){let n=!1;const i=new Proxy(s,{get(s,r){if(p(n),r===a)return()=>C(t,{type:"RELEASE",path:e.map((t=>t.toString()))}).then((()=>{m(t),n=!0}));if("then"===r){if(0===e.length)return{then:()=>i};const s=C(t,{type:"GET",path:e.map((t=>t.toString()))}).then(v);return s.then.bind(s)}return g(t,[...e,r])},set(s,i,r){p(n);const[o,a]=b(r);return C(t,{type:"SET",path:[...e,i].map((t=>t.toString())),value:o},a).then(v)},apply(s,i,r){p(n);const a=e[e.length-1];if(a===o)return C(t,{type:"ENDPOINT"}).then(v);if("bind"===a)return g(t,e.slice(0,-1));const[l,h]=y(r);return C(t,{type:"APPLY",path:e.map((t=>t.toString())),argumentList:l},h).then(v)},construct(s,i){p(n);const[r,o]=y(i);return C(t,{type:"CONSTRUCT",path:e.map((t=>t.toString())),argumentList:r},o).then(v)}});return i}function f(t){return Array.prototype.concat.apply([],t)}function y(t){const e=t.map(b);return[e.map((t=>t[0])),f(e.map((t=>t[1])))]}const w=new WeakMap;function b(t){for(const[e,s]of c)if(s.canHandle(t)){const[n,i]=s.serialize(t);return[{type:"HANDLER",name:e,value:n},i]}return[{type:"RAW",value:t},w.get(t)||[]]}function v(t){switch(t.type){case"HANDLER":return c.get(t.name).deserialize(t.value);case"RAW":return t.value}}function C(t,e,s){return new Promise((n=>{const i=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");t.addEventListener("message",(function e(s){!s.data||!s.data.id||s.data.id!==i||(t.removeEventListener("message",e),n(s.data))})),t.start&&t.start(),t.postMessage(Object.assign({id:i},e),s)}))}const S="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),u=(s.data.argumentList||[]).map(m);let l;try{const c=n.slice(0,-1).reduce((d,h)=>d[h],e),f=n.reduce((d,h)=>d[h],e);switch(a){case"GET":l=f;break;case"SET":c[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(c,u);break;case"CONSTRUCT":{const d=new f(...u);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:h}=new MessageChannel;w(e,h),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(c){l={value:c,[y]:0}}Promise.resolve(l).catch(c=>({value:c,[y]:0})).then(c=>{const[f,d]=S(c);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),F(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function F(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function p(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(p(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(u=>u.toString())}).then(()=>{F(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const u=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return u.then.bind(u)}return b(e,[...r,n])},set(a,n,u){p(s);const[l,c]=S(u);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},c).then(m)},apply(a,n,u){p(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[c,f]=M(u);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:c},f).then(m)},construct(a,n){p(s);const[u,l]=M(n);return g(e,{type:"CONSTRUCT",path:r.map(c=>c.toString()),argumentList:u},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function M(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),x="eager",k="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const u=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${u}`),t.fs.symlink(u,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var u;let n=i;return((u=a==null?void 0:a.features)==null?void 0:u.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==k&&(s.loading=x,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};if(t.config.printInterleaved&&(o=s.stdout),s.reinit===!0){const a=t.base.module.FS.cwd();Object.assign(s,s.config),s.ready=!1,await this.init(),s.isBaseModule&&this.mount(),this.cd(a)}return o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=x),e.loading===k){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>e.stdout+=`${i}
`,printErr:t.config.printInterleaved?i=>e.stdout+=`${i}
`:i=>e.stderr+=`${i}
`});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",M=typeof window<"u"&&window.Blob&&new Blob([atob(S)],{type:"text/javascript;charset=utf-8"});function A(){const t=M&&(window.URL||window.webkitURL).createObjectURL(M);try{return t?new Worker(t):new Worker("data:application/javascript;base64,"+S)}finally{t&&(window.URL||window.webkitURL).revokeObjectURL(t)}}const T={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,callback:null,debug:!1,env:"prd"};class E{constructor(t,e={}){if(null==t)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(t)||(t=[t]),e=Object.assign({},T,e),t=t.map(this._parseTool),"stg"===e.env&&(e.urlCDN=e.urlCDNStg),this.tools=t,this.config=e,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const t=new A;this.callback&&(t.onmessage=t=>{"biowasm"===t.data.type&&this.callback(t.data.value)});const e=d(t);return e.tools=this.tools,e.config=this.config,await e.init(),e}_parseTool(t){if("string"!=typeof t)return t;const e=t.split("/");if(2!=e.length&&3!=e.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:e[0],program:3==e.length?e[1]:e[0],version:e[e.length-1]}}}var x=s(7997);class N{static getAvailableScales(){return Object.entries(this.scales).map((([t,e])=>t))}static getScale(t){return(0,x.hu)(!(void 0===this.scales[t]),`Scale '${t}' was not found.`),this.scales[t]}}N.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class L{constructor(t="categorial"){this.aa2num=N.getScale(t),this.num2aa={},Object.entries(this.aa2num).forEach((([t,e])=>this.num2aa[e]=t))}static _truncateSequence(t){let e=0,s=t.length;const n=["NH2","COOH"];if(t.startsWith(n[0])){const s=n[0].length;(0,x.hu)("-"==t[s],`Wrong sequence format: ${n[0]} without following '-' in '${t}'.`),e=s}if(t.endsWith(n[1])){const e=n[1].length+1;(0,x.hu)("-"==t[s-e],`Wrong sequence format: ${n[1]} without '-' precending in '${t}'.`),s-=e}return t.substring(e,s)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return L._dropDefises(L._truncateSequence(t))}encode(t){const e=t.length,s=new Array(e).fill(0);for(let n=0;n<e;++n){const e=t[n];(0,x.hu)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),s[n]=this.encodeLettter(e)}return s}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let s=0;s<t.length;++s){const n=t[s];(0,x.hu)(n in this.num2aa,`Unknown code '${n}' found in vector '${t}'`),e+=this.num2aa[n]}return e}}var I=s(3553);const _="input.fa",R="result.fasta";function O(t){return t.reduce(((t,e,s)=>t+`>sample${s+1}\n${e}\n`),"")}async function k(t,e=!1,s="",r=null,o,a,l){let h=t.toList();e&&(h=h.map((t=>L.clean(t).replace(/\-/g,""))));const c=t.length;r??(r=n.Column.string("Clusters",c).init("0")),r.type!=n.COLUMN_TYPE.STRING&&(r=r.convertTo(n.TYPE.STRING)),r.compact();const u=r.categories,m=r.getRawData(),d=new Array(u.length),p=new Array(u.length);for(let t=0;t<c;++t){const e=m[t];(d[e]??(d[e]=[])).push(h[t]),(p[e]??(p[e]=[])).push(t)}const g=await new E(["base/1.0.0",{tool:"kalign",version:I.WY,reinit:!0}]),f=n.Column.string(s,c);for(let t=0;t<u.length;++t){const e=O(d[t]);await g.fs.writeFile(_,e);const s=`${void 0!==o?` --gpo ${o}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,n=await g.exec(`kalign ${_} -f fasta -o ${R}${s}`);console.warn(n);const r=await g.cat(R);if(!r)throw new Error("kalign output no result");const h=new i.i(r).sequencesArray,c=p[t];for(let t=0;t<h.length;++t)f.set(c[t],h[t])}const y=t.getTag(n.TAGS.UNITS),w=t.getTag("alphabet");return f.setTag(n.TAGS.UNITS,y),f.setTag("aligned","SEQ.MSA"),f.setTag("alphabet",w),f.semType=n.SEMTYPE.MACROMOLECULE,f}},8341:(t,e,s)=>{"use strict";s.d(e,{J:()=>a,f:()=>h});var n=s(4469),i=s(976),r=s(8447),o=s(3553);const a=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function h(t,e,s="ginsi",a=1.53,h=0,u=null){const m=await n.dapi.docker.dockerContainers.filter("bio").first();if("started"!==m.status&&"checking"!==m.status)return n.log.warning("PepSeA container has not started yet"),null;const d=t.length;u??(u=i.Column.int("Clusters",d).init(0)),u.type!=i.COLUMN_TYPE.STRING&&(u=u.convertTo(i.TYPE.STRING));const p=u.categories,g=new Array(p.length);for(let e=0;e<d;++e){const s=u.get(e);if(""===s)continue;const n=p.indexOf(s),i=t.get(e);i&&(g[n]??(g[n]=[])).push({ID:e.toString(),HELM:i})}const f=new Array(d);for(const t of g){const e=(await c(m.id,t,s,a,h)).Alignment;for(const t of e)f[parseInt(t.ID)]=Object.entries(t).filter((t=>!l.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(o.rs.SEPARATOR)}const y=i.Column.fromStrings(e,f);return y.setTag(i.TAGS.UNITS,r.r2.SEPARATOR),y.setTag("separator",o.rs.SEPARATOR),y.setTag("aligned","SEQ.MSA"),y.setTag("alphabet","UN"),y.setTag(".alphabetIsMultichar","true"),y.semType=i.SEMTYPE.MACROMOLECULE,y}async function c(t,e,s,i,r){const o={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},a=`/align?method=${s}&gap_open=${i}&gap_extend=${r}`,l=await n.dapi.docker.dockerContainers.request(t,a,o);return JSON.parse(l??"{}")}},9943:(t,e,s)=>{"use strict";s.d(e,{C2:()=>u});var n=s(976),i=s(3870),r=s(4469),o=s(6414),a=s.n(o),l=s(8447),h=s(499);const c=60;function u(){const t=r.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==n.SEMTYPE.MACROMOLECULE)).toArray(),s=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),o=s?[s.name]:[],u=i.multiChoiceInput("Seq id columns",o,e.map((t=>t.name))),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==n.SEMTYPE.MACROMOLECULE)&&h.Cn.getOrCreate(e).isFasta()})).toArray(),p=d.length>0?d[0].name:[],g=i.choiceInput("Seq column",p,d.map((t=>t.name))),f=i.intInput("FASTA line width",c);i.dialog({title:"Save as FASTA"}).add(i.inputs([u,g,f])).onOK((()=>{const e=u.value?u.value.map((e=>t.columns.byName(e).column)):[],s=g.value?t.columns.byName(g.value).column:null,n=f.value??c;s||r.shell.warning("Seq column is mandatory to save as FASTA.");const i=function(t,e,s=c,n="\n"){const i=l.kB,r=[];for(let o=0;o<e.length;o++){const a=t.map((t=>t.get(o).toString())).join("|"),l=m(e.get(o),i,s);r.push(`>${a}${n}`);for(const t of l)r.push(`${t}${n}`)}return"".concat(...r)}(e,s,n),o=document.createElement("a");o.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(i)}`),o.setAttribute("download",`${t.dataFrame.name}.fasta`),o.click()})).show()}function m(t,e,s=c){const n=e(t);let i=0;const r=n.length,o=[];for(;i<r;){const t=a()(n).slice(i,i+s).toArray(),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");o.push(e),i+=t.length}return o}},9416:(t,e,s)=>{"use strict";s.d(e,{n:()=>h});var n=s(4469),i=s(976),r=s(1061),o=s(2568),a=s(8457),l=s(3553);async function h(t,e){if(await(0,r.gw)(10),!(0,o.n)(e,"Sequence space"))return t;const s=(0,a.O)(e);s.name="splitToMonomers";const h=e.dataFrame;for(const t of s.columns)t.semType=l.Of.MONOMER,t.setTag("alphabet",e.getTag("alphabet"));const c=/(\d+)(?: \((\d+)\))?/,u=t=>{c.lastIndex=0;const e=t.match(c);return e?`${e[1]} (${parseInt(e[2]??0)+1})`:t};for(let t=0;t<s.columns.length;t++){const n=s.columns.byIndex(t);n.semType=l.Of.MONOMER,n.setTag("alphabet",e.getTag("alphabet"));const i=100;let r=0;for(;h.columns.byName(n.name)&&r<i;)n.name=u(n.name),r++;h.columns.add(n)}await n.data.detectSemanticTypes(h);for(let t=0;t<s.columns.length;t++)s.columns.byIndex(t).setTag(i.TAGS.CELL_RENDERER,"Monomer");return h}},4293:(t,e,s)=>{"use strict";s.d(e,{B:()=>r,Y:()=>o});var n=s(4469),i=s(976);function r(){const t=n.shell.t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);if(null!==t)return t;n.shell.error("Current table does not contain macromolecules")}function o(t,e){t.innerHTML="",t.append(e)}},833:(t,e,s)=>{"use strict";s.d(e,{bo:()=>p,OZ:()=>v});var n=s(4469),i=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(701),h=s(499),c=s(8447),u=s(9298);function m(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?m(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var d,p,g=s(4941);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const s=this.getBoundingClientRect();return new r.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class f{constructor(t=0,e){this.count=t,this.bounds=e}}class y{get label(){return this._label?this._label:this.name}constructor(t,e,s,n){this.pos=t,this.name=e,this._freqs=s??{},n?.rowCount&&(this.rowCount=n.rowCount),n?.sumForHeightCalc&&(this.sumForHeightCalc=n.sumForHeightCalc),n?.label&&(this._label=n.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new f),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,n])=>n.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,n,i,o,a,l,h){const c=n==u.ES.Entropy?s*(i-this.sumForHeightCalc)/i:s;let m=h*l+(s-c-1);const d=Object.entries(this._freqs).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const s of d){const n=s[1],i=c*n.count/this.rowCount;n.bounds=new r.Rect((t-e)*l*o,m,a*l,i),m+=i}}render(t,e,s,n,i){for(const[r,o]of Object.entries(this._freqs))if("-"!==r){const a=(0,c.GU)(r,5),l=o.bounds,h=l.left;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(h,l.top,l.width,l.height),t.fillStyle=i.get(r)??i.get("other"),t.textAlign="left",t.font=e;const u=t.measureText(a);t.setTransform(l.width/u.width,0,0,l.height/n,h,l.top),t.fillText(a,0,-s)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(p||(p={}));const w=u.vS;var b;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(b||(b={}));class v extends r.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewSubs=[],this._onSizeChanged=new l.Subject,this._onFreqsCalculated=new l.Subject,this._onLayoutCalculated=new l.Subject,this.renderLevelRequested=b.Freqs,this.viewerId=v.viewerCount,v.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(p.sequenceColumnName,w.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(p.startPositionName,w.startPositionName,{category:d.DATA}),this.endPositionName=this.string(p.endPositionName,w.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(p.skipEmptySequences,w.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(p.skipEmptyPositions,w.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(p.shrinkEmptyTail,w.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(p.backgroundColor,w.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(p.positionHeight,w.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(p.positionWidth,w.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(p.verticalAlignment,w.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(p.horizontalAlignment,w.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(p.fixWidth,w.fixWidth,{category:d.LAYOUT,userEditable:!1}),this.fitArea=this.bool(p.fitArea,w.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(p.minHeight,w.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(p.maxHeight,w.maxHeight,{category:d.LAYOUT}),this.showPositionLabels=this.bool(p.showPositionLabels,w.showPositionLabels,{category:d.LAYOUT}),this.positionMarginState=this.string(p.positionMarginState,w.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(p.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(p.filterSource,w.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=i.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=i.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%"}setData(){this.viewed&&(this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.viewed||(this.buildView(),this.viewed=!0)}async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),super.detach(),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=i.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=i.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=i.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,i.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),await this.render(b.Freqs,"buildView"),g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(b.Layout,"rootOnSizeChanged").then((()=>{}))}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqCol.getTag(r.TAGS.UNITS),this.seqCol.getTag("separator"),this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.cp=(0,c.dQ)(this.seqCol),this.updatePositions(),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,e=a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(".positionNames"),n=this.seqCol.getTag(".positionLabels");this.positionNames=s?s.split(c.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=n?n.split(c.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1,this.render(b.Freqs,"updatePositions").then((()=>{}))}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&0!==this.root.clientHeight&&0!==this.root.clientWidth&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.fitArea?this.calcLayoutFitArea(t):this.calcLayoutNoFitArea(t))}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=u.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,this.Length-1,0,this.Length-1),this.canvas.width=e*t,this.canvas.height=s*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=Math.min(this.root.clientWidth,e);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${n}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+6}px`),this.host.style.width=`${this.host}px`;const i=e>n;if(this.setSliderVisibility(i),i){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=n*t,this.canvas.height=s*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,i=this.root.clientHeight/s,r=Math.max(1,Math.min(n,i));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*s,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const h=o>l;if(this.setSliderVisibility(h),h){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=l*t,this.canvas.height=a*t}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case p.sequenceColumnName:this.updateSeqCol();break;case p.sequenceColumnName:case p.startPositionName:case p.endPositionName:case p.filterSource:case p.shrinkEmptyTail:case p.skipEmptyPositions:case p.positionHeight:this.updatePositions();break;case p.minHeight:case p.maxHeight:case p.positionWidth:case p.showPositionLabels:case p.fixWidth:case p.fitArea:case p.horizontalAlignment:case p.verticalAlignment:case p.positionMargin:case p.positionMarginState:this.render(b.Layout,`onPropertyChanged(${t.name})`).then((()=>{}));break;case p.backgroundColor:this.render(b.Render,`onPropertyChanged(${t.name})`).then((()=>{}))}}onTableAttached(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){this.viewed&&(this.destroyView(),this.viewed=!1)}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const s=t.x,n=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),i=this.positions[n];if(void 0===i)return[n,null,null];const r=i.getMonomerAt(s,t.y);return void 0===r?[n,null,null]:[n,r,i.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>!t.hasMonomer("-")||t.getFreq("-").count!==t.rowCount)).toArray())}render(t,e){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevel=${t}, reason='${e}' )`);const s=()=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new y(this.startPosition+e,t,{},{label:s})}const s=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,n=this.dataFrame.rowCount,i=this.unitsHandler.splitted;for(let e=0;e<n;++e)if(s.get(e)){const s=i[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||"-";this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()},i=(t,e)=>{g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `),this.calcLayout(t);const s=this.canvas.height-e*t,i=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==i&&n.shell.error("WebLogo: alphabet is undefined.");const r=Math.log2(i);for(let n=Math.floor(this.slider.min);n<=Math.floor(this.slider.max);++n)this.positions[n].calcScreen(n,this.slider.min,s,this.positionHeight,r,this._positionWidthWithMargin,this._positionWidth,t,e);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()},o=t=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const n=window.devicePixelRatio,o=this.showPositionLabels?12:0;t>=b.Freqs&&s(),t>=b.Layout&&i(window.devicePixelRatio,o),this.Length,e.resetTransform(),e.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const a=10*n;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),h=l<this._positionWidth*n-2?1:(this._positionWidth*n-2)/l;o>0&&function(t,e,s,n,i,r,o,a){for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=r[l];t.resetTransform(),t.setTransform(s,0,0,1,(l-o)*n*e+i*e/2,0),t.fillText(a.label,0,1)}}(e,n,h,this._positionWidthWithMargin,this._positionWidth,this.positions,this.slider.min,this.slider.max);for(let t=Math.floor(this.slider.min);t<=Math.floor(this.slider.max);t++)this.positions[t].render(e,"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.cp);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)};return this.renderLevelRequested=Math.max(this.renderLevelRequested,t),new Promise(((t,e)=>{window.setTimeout((()=>{try{if(this.renderLevelRequested>b.None)try{o(this.renderLevelRequested)}finally{this.renderLevelRequested=b.None}}catch(t){e(t)}}),0)}))}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(t)} ), start`),this.render(b.Layout,"sliderOnValuesChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){g._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()");try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(b.Freqs,"dataFrameFilterOnChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){g._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()");try{this.filterSource===u.Ct.Selected&&this.render(b.Freqs,"dataFrameSelectionOnChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,n=this.canvas.getCursorPosition(s,e),[r,o]=this.getMonomer(n,e);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],e=function(t,e,s,n,i){let r=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const t=e.splitted[o],s=i.pos;(s<t.length?t[s]:null)===n&&r++}return r}(this.dataFrame,this.unitsHandler,this.filter,o,t),n=i.div([i.div(`${o}`),i.div(`${e} rows`)]);i.tooltip.show(n,s.x+16,s.y+16)}else i.tooltip.hide()}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[n,i]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&i){const t=this.positions[n],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,n,i,r){const o=e.splitted[n],a=r.pos<o.length?o[r.pos]:null;return a===i||""===a&&"-"===i}(this.dataFrame,this.unitsHandler,this.filter,e,i,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*e),n=t.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+n)}catch(t){const e=m(t);g._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n"+e)}}}v.residuesSet="nucleotides",v.viewerCount=0},4413:(t,e,s)=>{"use strict";s.d(e,{ST:()=>p});var n=s(3870),i=s(976),r=s(4469),o=s(6414),a=s.n(o),l=s(7983),h=s(701),c=s(4293),u=s(8447),m=s(1061);const d=rxjs.operators;class p extends i.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=n.loader(),this.notation=void 0,this.root=n.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(i.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(i.TAGS.UNITS)),this.bioFilter=this.notation===u.r2.FASTA?new f:this.notation===u.r2.SEPARATOR?new y(this.column.getTag("separator")):new w,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class g{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class f extends g{constructor(){super(),this.substructureInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class y extends f{constructor(t){super(),this.colSeparator="",this.separatorInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return n.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t,this.colSeparator)}}class w extends g{constructor(){super(),this._filterPanel=n.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await r.functions.call("HELM:helmWebEditor"),await n.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:s}=this.helmEditor.createWebEditor(this.helmSubstructure);n.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),n.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=e/2;if(t)(0,c.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,s);else{const t=n.divText("Click to edit","helm-substructure-filter");(0,c.Y)(this._filterPanel,t)}}async substrucrureSearch(t){n.setUpdateIndicator(this._filterPanel,!0),await(0,m.gw)(10);const e=await(0,l.QF)(this.substructure,t);return n.setUpdateIndicator(this._filterPanel,!1),e}}},9378:function(t,e,s){"use strict";var n=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var i=n(s(4517));function r(t,e){var s=function(s){return i.empty(t).map((function(){return i.filled(e,s)}))},n=[];return n.push(s(-1)),n.push(s(1/0)),n.push(s(0)),n}function o(t,e,s,n,i){e=Math.floor(e);var r=t[0][e],o=t[1][e];if(t[2][e],s>=o[0])return 0;for(var l=0;l<r.length;l++)if(n===r[l])return 0;return a(t,e,s,n,i)}function a(t,e,s,n,i){var r=t[0][e],o=t[1][e],a=t[2][e];if(s>=o[0])return 0;o[0]=s,r[0]=n,a[0]=i;for(var l=0,h=0;;){var c=2*l+1,u=c+1,m=t[0][0].length;if(c>=m)break;if(u>=m){if(!(o[c]>s))break;h=c}else if(o[c]>=o[u]){if(!(s<o[c]))break;h=c}else{if(!(s<o[u]))break;h=u}o[l]=o[h],r[l]=r[h],a[l]=a[h],l=h}return o[l]=s,r[l]=n,a[l]=i,1}function l(t,e,s,n){for(;2*n+1<s;){var i=2*n+1,r=i+1,o=n;if(t[o]<t[i]&&(o=i),r<s&&t[o]<t[r]&&(o=r),o===n)break;var a=t[n];t[n]=t[o],t[o]=a;var l=e[n];e[n]=e[o],e[o]=l,n=o}}e.makeHeap=r,e.rejectionSample=function(t,e,s){for(var n=i.zeros(t),r=0;r<t;r++){for(var o=!0,a=0;o;){a=i.tauRandInt(e,s);for(var l=!1,h=0;h<r;h++)if(a===n[h]){l=!0;break}l||(o=!1)}n[r]=a}return n},e.heapPush=o,e.uncheckedHeapPush=a,e.buildCandidates=function(t,e,s,n,a){for(var l=r(e,n),h=0;h<e;h++)for(var c=0;c<s;c++)if(!(t[0][h][c]<0)){var u=t[0][h][c],m=t[2][h][c],d=i.tauRand(a);o(l,h,d,u,m),o(l,u,d,h,m),t[2][h][c]=0}return l},e.deheapSort=function(t){for(var e=t[0],s=t[1],n=0;n<e.length;n++)for(var i=e[n],r=s[n],o=0;o<i.length-1;o++){var a=i.length-o-1,h=r.length-o-1,c=i[0];i[0]=i[a],i[a]=c;var u=r[0];r[0]=r[h],r[h]=u,l(r,i,h,0)}return{indices:e,weights:s}},e.smallestFlagged=function(t,e){for(var s=t[0][e],n=t[1][e],i=t[2][e],r=1/0,o=-1,a=0;a>s.length;a++)1===i[a]&&n[a]<r&&(r=n[a],o=a);return o>=0?(i[o]=0,Math.floor(s[o])):-1}},4221:(t,e,s)=>{"use strict";var n=s(4364);e.u=n.UMAP},5686:function(t,e,s){"use strict";var n,i=this&&this.__read||function(t,e){var s="function"==typeof Symbol&&t[Symbol.iterator];if(!s)return t;var n,i,r=s.call(t),o=[];try{for(;(void 0===e||e-- >0)&&!(n=r.next()).done;)o.push(n.value)}catch(t){i={error:t}}finally{try{n&&!n.done&&(s=r.return)&&s.call(r)}finally{if(i)throw i.error}}return o},r=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}},o=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var a=o(s(4517)),l=function(){function t(t,e,s,n){if(this.entries=new Map,this.nRows=0,this.nCols=0,t.length!==e.length||t.length!==s.length)throw new Error("rows, cols and values arrays must all have the same length");this.nRows=n[0],this.nCols=n[1];for(var i=0;i<s.length;i++){var r=t[i],o=e[i];this.checkDims(r,o);var a=this.makeKey(r,o);this.entries.set(a,{value:s[i],row:r,col:o})}}return t.prototype.makeKey=function(t,e){return t+":"+e},t.prototype.checkDims=function(t,e){if(!(t<this.nRows&&e<this.nCols))throw new Error("row and/or col specified outside of matrix dimensions")},t.prototype.set=function(t,e,s){this.checkDims(t,e);var n=this.makeKey(t,e);this.entries.has(n)?this.entries.get(n).value=s:this.entries.set(n,{value:s,row:t,col:e})},t.prototype.get=function(t,e,s){void 0===s&&(s=0),this.checkDims(t,e);var n=this.makeKey(t,e);return this.entries.has(n)?this.entries.get(n).value:s},t.prototype.getAll=function(t){void 0===t&&(t=!0);var e=[];return this.entries.forEach((function(t){e.push(t)})),t&&e.sort((function(t,e){return t.row===e.row?t.col-e.col:t.row-e.row})),e},t.prototype.getDims=function(){return[this.nRows,this.nCols]},t.prototype.getRows=function(){return Array.from(this.entries,(function(t){var e=i(t,2);return e[0],e[1].row}))},t.prototype.getCols=function(){return Array.from(this.entries,(function(t){var e=i(t,2);return e[0],e[1].col}))},t.prototype.getValues=function(){return Array.from(this.entries,(function(t){var e=i(t,2);return e[0],e[1].value}))},t.prototype.forEach=function(t){this.entries.forEach((function(e){return t(e.value,e.row,e.col)}))},t.prototype.map=function(e){var s=[];this.entries.forEach((function(t){s.push(e(t.value,t.row,t.col))}));var n=[this.nRows,this.nCols];return new t(this.getRows(),this.getCols(),s,n)},t.prototype.toArray=function(){var t=this,e=a.empty(this.nRows).map((function(){return a.zeros(t.nCols)}));return this.entries.forEach((function(t){e[t.row][t.col]=t.value})),e},t}();e.SparseMatrix=l,e.transpose=function(t){var e=[],s=[],n=[];t.forEach((function(t,i,r){e.push(i),s.push(r),n.push(t)}));var i=[t.nCols,t.nRows];return new l(s,e,n,i)},e.identity=function(t){for(var e=i(t,1)[0],s=new l([],[],[],t),n=0;n<e;n++)s.set(n,n,1);return s},e.pairwiseMultiply=function(t,e){return c(t,e,(function(t,e){return t*e}))},e.add=function(t,e){return c(t,e,(function(t,e){return t+e}))},e.subtract=function(t,e){return c(t,e,(function(t,e){return t-e}))},e.maximum=function(t,e){return c(t,e,(function(t,e){return t>e?t:e}))},e.multiplyScalar=function(t,e){return t.map((function(t){return t*e}))},e.eliminateZeros=function(t){for(var e=new Set,s=t.getValues(),n=t.getRows(),i=t.getCols(),r=0;r<s.length;r++)0===s[r]&&e.add(r);var o=function(t,s){return!e.has(s)},a=s.filter(o),h=n.filter(o),c=i.filter(o);return new l(h,c,a,t.getDims())},e.normalize=function(t,e){var s,n;void 0===e&&(e="l2");var i=h[e],o=new Map;t.forEach((function(t,e,s){var n=o.get(e)||[];n.push(s),o.set(e,n)}));var a=new l([],[],[],t.getDims()),c=function(e){for(var s=o.get(e).sort(),n=s.map((function(s){return t.get(e,s)})),r=i(n),l=0;l<r.length;l++)a.set(e,s[l],r[l])};try{for(var u=r(o.keys()),m=u.next();!m.done;m=u.next())c(m.value)}catch(t){s={error:t}}finally{try{m&&!m.done&&(n=u.return)&&n.call(u)}finally{if(s)throw s.error}}return a};var h=((n={}).max=function(t){for(var e=-1/0,s=0;s<t.length;s++)e=t[s]>e?t[s]:e;return t.map((function(t){return t/e}))},n.l1=function(t){for(var e=0,s=0;s<t.length;s++)e+=t[s];return t.map((function(t){return t/e}))},n.l2=function(t){for(var e=0,s=0;s<t.length;s++)e+=Math.pow(t[s],2);return t.map((function(t){return Math.sqrt(Math.pow(t,2)/e)}))},n);function c(t,e,s){for(var n=new Set,i=[],r=[],o=[],a=function(n,a){i.push(n),r.push(a);var l=s(t.get(n,a),e.get(n,a));o.push(l)},h=t.getValues(),c=t.getRows(),u=t.getCols(),m=0;m<h.length;m++){var d=(y=c[m])+":"+(w=u[m]);n.add(d),a(y,w)}var p=e.getValues(),g=e.getRows(),f=e.getCols();for(m=0;m<p.length;m++){var y,w;d=(y=g[m])+":"+(w=f[m]),n.has(d)||a(y,w)}var b=[t.nRows,t.nCols];return new l(i,r,o,b)}e.getCSR=function(t){var e=[];t.forEach((function(t,s,n){e.push({value:t,row:s,col:n})})),e.sort((function(t,e){return t.row===e.row?t.col-e.col:t.row-e.row}));for(var s=[],n=[],i=[],r=-1,o=0;o<e.length;o++){var a=e[o],l=a.row,h=a.col,c=a.value;l!==r&&(r=l,i.push(o)),s.push(h),n.push(c)}return{indices:s,values:n,indptr:i}}},760:function(t,e,s){"use strict";var n=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}},i=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var r=i(s(9378)),o=i(s(5686)),a=i(s(2320)),l=i(s(4517));e.makeNNDescent=function(t,e){return function(s,n,i,o,a,h,c,u){void 0===o&&(o=10),void 0===a&&(a=50),void 0===h&&(h=.001),void 0===c&&(c=.5),void 0===u&&(u=!0);for(var m=s.length,d=r.makeHeap(s.length,i),p=0;p<s.length;p++)for(var g=r.rejectionSample(i,s.length,e),f=0;f<g.length;f++){var y=t(s[p],s[g[f]]);r.heapPush(d,p,y,g[f],1),r.heapPush(d,g[f],y,p,1)}if(u)for(var w=0;w<n.length;w++)for(p=0;p<n[w].length&&!(n[w][p]<0);p++)for(f=p+1;f<n[w].length&&!(n[w][f]<0);f++)y=t(s[n[w][p]],s[n[w][f]]),r.heapPush(d,n[w][p],y,n[w][f],1),r.heapPush(d,n[w][f],y,n[w][p],1);for(w=0;w<o;w++){var b=r.buildCandidates(d,m,i,a,e),v=0;for(p=0;p<m;p++)for(f=0;f<a;f++){var C=Math.floor(b[0][p][f]);if(!(C<0||l.tauRand(e)<c))for(var S=0;S<a;S++){var M=Math.floor(b[0][p][S]),A=b[2][p][f],T=b[2][p][S];M<0||!A&&!T||(y=t(s[C],s[M]),v+=r.heapPush(d,C,y,M,1),v+=r.heapPush(d,M,y,C,1))}}if(v<=h*i*s.length)break}return r.deheapSort(d)}},e.makeInitializations=function(t){return{initFromRandom:function(e,s,n,i,o){for(var a=0;a<n.length;a++)for(var h=l.rejectionSample(e,s.length,o),c=0;c<h.length;c++)if(!(h[c]<0)){var u=t(s[h[c]],n[a]);r.heapPush(i,a,u,h[c],1)}},initFromTree:function(e,s,n,i,o){for(var l=0;l<n.length;l++)for(var h=a.searchFlatTree(n[l],e,o),c=0;c<h.length;c++){if(h[c]<0)return;var u=t(s[h[c]],n[l]);r.heapPush(i,l,u,h[c],1)}}}},e.makeInitializedNNSearch=function(t){return function(e,s,i,a){for(var l,h,c=o.getCSR(s),u=c.indices,m=c.indptr,d=0;d<a.length;d++)for(var p=new Set(i[0][d]);;){var g=r.smallestFlagged(i,d);if(-1===g)break;var f=u.slice(m[g],m[g+1]);try{for(var y=n(f),w=y.next();!w.done;w=y.next()){var b=w.value;if(b!==g&&-1!==b&&!p.has(b)){var v=t(e[b],a[d]);r.uncheckedHeapPush(i,d,v,b,1),p.add(b)}}}catch(t){l={error:t}}finally{try{w&&!w.done&&(h=y.return)&&h.call(y)}finally{if(l)throw l.error}}}return i}},e.initializeSearch=function(t,e,s,i,o,a,l){var h,c,u=r.makeHeap(s.length,i);if(o(i,e,s,u,l),t)try{for(var m=n(t),d=m.next();!d.done;d=m.next())a(d.value,e,s,u,l)}catch(t){h={error:t}}finally{try{d&&!d.done&&(c=m.return)&&c.call(m)}finally{if(h)throw h.error}}return u}},2320:function(t,e,s){"use strict";var n=this&&this.__read||function(t,e){var s="function"==typeof Symbol&&t[Symbol.iterator];if(!s)return t;var n,i,r=s.call(t),o=[];try{for(;(void 0===e||e-- >0)&&!(n=r.next()).done;)o.push(n.value)}catch(t){i={error:t}}finally{try{n&&!n.done&&(s=r.return)&&s.call(r)}finally{if(i)throw i.error}}return o},i=this&&this.__spread||function(){for(var t=[],e=0;e<arguments.length;e++)t=t.concat(n(arguments[e]));return t},r=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}},o=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var a=o(s(4517)),l=function(t,e,s,n){this.hyperplanes=t,this.offsets=e,this.children=s,this.indices=n};function h(t,e,s,n,i){if(void 0===s&&(s=30),e.length>s){var r=function(t,e,s){var n=t[0].length,i=a.tauRandInt(e.length,s),r=a.tauRandInt(e.length,s);r=(r+=i===r?1:0)%e.length;for(var o=e[i],l=e[r],h=0,c=a.zeros(n),u=0;u<c.length;u++)c[u]=t[o][u]-t[l][u],h-=c[u]*(t[o][u]+t[l][u])/2;var m=0,d=0,p=a.zeros(e.length);for(u=0;u<e.length;u++){for(var g=h,f=0;f<n;f++)g+=c[f]*t[e[u]][f];0===g?(p[u]=a.tauRandInt(2,s),0===p[u]?m+=1:d+=1):g>0?(p[u]=0,m+=1):(p[u]=1,d+=1)}var y=a.zeros(m),w=a.zeros(d);for(m=0,d=0,u=0;u<p.length;u++)0===p[u]?(y[m]=e[u],m+=1):(w[d]=e[u],d+=1);return{indicesLeft:y,indicesRight:w,hyperplane:c,offset:h}}(t,e,i),o=r.indicesLeft,l=r.indicesRight,c=r.hyperplane,u=r.offset;return{leftChild:h(t,o,s,n+1,i),rightChild:h(t,l,s,n+1,i),isLeaf:!1,hyperplane:c,offset:u}}return{indices:e,isLeaf:!0}}function c(t,e,s,n,r,o,a){var l;if(t.isLeaf)return n[o][0]=-a,(l=r[a]).splice.apply(l,i([0,t.indices.length],t.indices)),{nodeNum:o,leafNum:a+=1};e[o]=t.hyperplane,s[o]=t.offset,n[o][0]=o+1;var h=o,u=c(t.leftChild,e,s,n,r,o+1,a);return o=u.nodeNum,a=u.leafNum,n[h][1]=o+1,{nodeNum:(u=c(t.rightChild,e,s,n,r,o+1,a)).nodeNum,leafNum:u.leafNum}}function u(t){return t.isLeaf?1:1+u(t.leftChild)+u(t.rightChild)}function m(t){return t.isLeaf?1:m(t.leftChild)+m(t.rightChild)}function d(t,e,s,n){for(var i=e,r=0;r<s.length;r++)i+=t[r]*s[r];return 0===i?a.tauRandInt(2,n):i>0?0:1}e.FlatTree=l,e.makeForest=function(t,e,s,n){var i=Math.max(10,e);return a.range(s).map((function(e,s){return function(t,e,s,n){return void 0===e&&(e=30),h(t,a.range(t.length),e,s,n)}(t,i,s,n)})).map((function(t){return function(t,e){var s=u(t),n=m(t),i=a.range(s).map((function(){return a.zeros(t.hyperplane?t.hyperplane.length:0)})),r=a.zeros(s),o=a.range(s).map((function(){return[-1,-1]})),h=a.range(n).map((function(){return a.range(e).map((function(){return-1}))}));return c(t,i,r,o,h,0,0),new l(i,r,o,h)}(t,i)}))},e.makeLeafArray=function(t){var e,s;if(t.length>0){var n=[];try{for(var o=r(t),a=o.next();!a.done;a=o.next()){var l=a.value;n.push.apply(n,i(l.indices))}}catch(t){e={error:t}}finally{try{a&&!a.done&&(s=o.return)&&s.call(o)}finally{if(e)throw e.error}}return n}return[[-1]]},e.searchFlatTree=function(t,e,s){for(var n=0;e.children[n][0]>0;)n=0===d(e.hyperplanes[n],e.offsets[n],t,s)?e.children[n][0]:e.children[n][1];var i=-1*e.children[n][0];return e.indices[i]}},4364:function(t,e,s){"use strict";var n=this&&this.__awaiter||function(t,e,s,n){return new(s||(s=Promise))((function(i,r){function o(t){try{l(n.next(t))}catch(t){r(t)}}function a(t){try{l(n.throw(t))}catch(t){r(t)}}function l(t){t.done?i(t.value):new s((function(e){e(t.value)})).then(o,a)}l((n=n.apply(t,e||[])).next())}))},i=this&&this.__generator||function(t,e){var s,n,i,r,o={label:0,sent:function(){if(1&i[0])throw i[1];return i[1]},trys:[],ops:[]};return r={next:a(0),throw:a(1),return:a(2)},"function"==typeof Symbol&&(r[Symbol.iterator]=function(){return this}),r;function a(r){return function(a){return function(r){if(s)throw new TypeError("Generator is already executing.");for(;o;)try{if(s=1,n&&(i=2&r[0]?n.return:r[0]?n.throw||((i=n.return)&&i.call(n),0):n.next)&&!(i=i.call(n,r[1])).done)return i;switch(n=0,i&&(r=[2&r[0],i.value]),r[0]){case 0:case 1:i=r;break;case 4:return o.label++,{value:r[1],done:!1};case 5:o.label++,n=r[1],r=[0];continue;case 7:r=o.ops.pop(),o.trys.pop();continue;default:if(!((i=(i=o.trys).length>0&&i[i.length-1])||6!==r[0]&&2!==r[0])){o=0;continue}if(3===r[0]&&(!i||r[1]>i[0]&&r[1]<i[3])){o.label=r[1];break}if(6===r[0]&&o.label<i[1]){o.label=i[1],i=r;break}if(i&&o.label<i[2]){o.label=i[2],o.ops.push(r);break}i[2]&&o.ops.pop(),o.trys.pop();continue}r=e.call(t,o)}catch(t){r=[6,t],n=0}finally{s=i=0}if(5&r[0])throw r[1];return{value:r[0]?r[1]:void 0,done:!0}}([r,a])}}},r=this&&this.__read||function(t,e){var s="function"==typeof Symbol&&t[Symbol.iterator];if(!s)return t;var n,i,r=s.call(t),o=[];try{for(;(void 0===e||e-- >0)&&!(n=r.next()).done;)o.push(n.value)}catch(t){i={error:t}}finally{try{n&&!n.done&&(s=r.return)&&s.call(r)}finally{if(i)throw i.error}}return o},o=this&&this.__spread||function(){for(var t=[],e=0;e<arguments.length;e++)t=t.concat(r(arguments[e]));return t},a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e},l=this&&this.__importDefault||function(t){return t&&t.__esModule?t:{default:t}};Object.defineProperty(e,"__esModule",{value:!0});var h=a(s(9378)),c=a(s(5686)),u=a(s(760)),m=a(s(2320)),d=a(s(4517)),p=l(s(9251)),g=1e-5,f=.001,y=function(){function t(t){void 0===t&&(t={});var e=this;this.learningRate=1,this.localConnectivity=1,this.minDist=.1,this.nComponents=2,this.nEpochs=0,this.nNeighbors=15,this.negativeSampleRate=5,this.random=Math.random,this.repulsionStrength=1,this.setOpMixRatio=1,this.spread=1,this.transformQueueSize=4,this.targetMetric="categorical",this.targetWeight=.5,this.targetNNeighbors=this.nNeighbors,this.distanceFn=w,this.isInitialized=!1,this.rpForest=[],this.embedding=[],this.optimizationState=new b;var s=function(s){void 0!==t[s]&&(e[s]=t[s])};s("distanceFn"),s("learningRate"),s("localConnectivity"),s("minDist"),s("nComponents"),s("nEpochs"),s("nNeighbors"),s("negativeSampleRate"),s("random"),s("repulsionStrength"),s("setOpMixRatio"),s("spread"),s("transformQueueSize")}return t.prototype.fit=function(t){return this.initializeFit(t),this.optimizeLayout(),this.embedding},t.prototype.fitAsync=function(t,e){return void 0===e&&(e=function(){return!0}),n(this,void 0,void 0,(function(){return i(this,(function(s){switch(s.label){case 0:return this.initializeFit(t),[4,this.optimizeLayoutAsync(e)];case 1:return s.sent(),[2,this.embedding]}}))}))},t.prototype.setSupervisedProjection=function(t,e){void 0===e&&(e={}),this.Y=t,this.targetMetric=e.targetMetric||this.targetMetric,this.targetWeight=e.targetWeight||this.targetWeight,this.targetNNeighbors=e.targetNNeighbors||this.targetNNeighbors},t.prototype.setPrecomputedKNN=function(t,e){this.knnIndices=t,this.knnDistances=e},t.prototype.initializeFit=function(t){if(t.length<=this.nNeighbors)throw new Error("Not enough data points ("+t.length+") to create nNeighbors: "+this.nNeighbors+". Add more data points or adjust the configuration.");if(this.X===t&&this.isInitialized)return this.getNEpochs();if(this.X=t,!this.knnIndices&&!this.knnDistances){var e=this.nearestNeighbors(t);this.knnIndices=e.knnIndices,this.knnDistances=e.knnDistances}this.graph=this.fuzzySimplicialSet(t,this.nNeighbors,this.setOpMixRatio),this.makeSearchFns(),this.searchGraph=this.makeSearchGraph(t),this.processGraphForSupervisedProjection();var s=this.initializeSimplicialSetEmbedding(),n=s.head,i=s.tail,r=s.epochsPerSample;return this.optimizationState.head=n,this.optimizationState.tail=i,this.optimizationState.epochsPerSample=r,this.initializeOptimization(),this.prepareForOptimizationLoop(),this.isInitialized=!0,this.getNEpochs()},t.prototype.makeSearchFns=function(){var t=u.makeInitializations(this.distanceFn),e=t.initFromTree,s=t.initFromRandom;this.initFromTree=e,this.initFromRandom=s,this.search=u.makeInitializedNNSearch(this.distanceFn)},t.prototype.makeSearchGraph=function(t){for(var e=this.knnIndices,s=this.knnDistances,n=[t.length,t.length],i=new c.SparseMatrix([],[],[],n),r=0;r<e.length;r++)for(var o=e[r],a=s[r],l=0;l<o.length;l++){var h=o[l],u=a[l];u>0&&i.set(r,h,u)}var m=c.transpose(i);return c.maximum(i,m)},t.prototype.transform=function(t){var e=this,s=this.X;if(void 0===s||0===s.length)throw new Error("No data has been fit.");var n=Math.floor(this.nNeighbors*this.transformQueueSize);n=Math.min(s.length,n);var i=u.initializeSearch(this.rpForest,s,t,n,this.initFromRandom,this.initFromTree,this.random),r=this.search(s,this.searchGraph,i,t),o=h.deheapSort(r),a=o.indices,l=o.weights;a=a.map((function(t){return t.slice(0,e.nNeighbors)})),l=l.map((function(t){return t.slice(0,e.nNeighbors)}));var m=Math.max(0,this.localConnectivity-1),p=this.smoothKNNDistance(l,this.nNeighbors,m),g=p.sigmas,f=p.rhos,y=this.computeMembershipStrengths(a,l,g,f),w=y.rows,b=y.cols,v=y.vals,C=[t.length,s.length],S=new c.SparseMatrix(w,b,v,C),M=c.normalize(S,"l1"),A=c.getCSR(M),E=t.length,x=T(d.reshape2d(A.indices,E,this.nNeighbors),d.reshape2d(A.values,E,this.nNeighbors),this.embedding),N=this.nEpochs?this.nEpochs/3:S.nRows<=1e4?100:30,L=S.getValues().reduce((function(t,e){return e>t?e:t}),0);S=S.map((function(t){return t<L/N?0:t})),S=c.eliminateZeros(S);var I=this.makeEpochsPerSample(S.getValues(),N),_=S.getRows(),R=S.getCols();return this.assignOptimizationStateParameters({headEmbedding:x,tailEmbedding:this.embedding,head:_,tail:R,currentEpoch:0,nEpochs:N,nVertices:S.getDims()[1],epochsPerSample:I}),this.prepareForOptimizationLoop(),this.optimizeLayout()},t.prototype.processGraphForSupervisedProjection=function(){var t=this.Y,e=this.X;if(t){if(t.length!==e.length)throw new Error("Length of X and y must be equal");if("categorical"===this.targetMetric){var s=this.targetWeight<1?1/(1-this.targetWeight)*2.5:1e12;this.graph=this.categoricalSimplicialSetIntersection(this.graph,t,s)}}},t.prototype.step=function(){var t=this.optimizationState.currentEpoch;return t<this.getNEpochs()&&this.optimizeLayoutStep(t),this.optimizationState.currentEpoch},t.prototype.getEmbedding=function(){return this.embedding},t.prototype.nearestNeighbors=function(t){var e,s=this.distanceFn,n=this.nNeighbors,i=u.makeNNDescent(s,this.random),r=5+Math.floor(.5==(e=Math.pow(t.length,.5)/20)?0:Math.round(e)),o=Math.max(5,Math.floor(Math.round(function(t){return Math.log(t)/Math.log(2)}(t.length))));this.rpForest=m.makeForest(t,n,r,this.random);var a=i(t,m.makeLeafArray(this.rpForest),n,o);return{knnIndices:a.indices,knnDistances:a.weights}},t.prototype.fuzzySimplicialSet=function(t,e,s){void 0===s&&(s=1);var n=this,i=n.knnIndices,r=void 0===i?[]:i,o=n.knnDistances,a=void 0===o?[]:o,l=n.localConnectivity,h=this.smoothKNNDistance(a,e,l),u=h.sigmas,m=h.rhos,d=this.computeMembershipStrengths(r,a,u,m),p=d.rows,g=d.cols,f=d.vals,y=[t.length,t.length],w=new c.SparseMatrix(p,g,f,y),b=c.transpose(w),v=c.pairwiseMultiply(w,b),C=c.subtract(c.add(w,b),v),S=c.multiplyScalar(C,s),M=c.multiplyScalar(v,1-s);return c.add(S,M)},t.prototype.categoricalSimplicialSetIntersection=function(t,e,s,n){void 0===n&&(n=1);var i=M(t,e,n,s);return A(i=c.eliminateZeros(i))},t.prototype.smoothKNNDistance=function(t,e,s,n,i){void 0===s&&(s=1),void 0===n&&(n=64),void 0===i&&(i=1);for(var r=Math.log(e)/Math.log(2)*i,o=d.zeros(t.length),a=d.zeros(t.length),l=0;l<t.length;l++){var h=0,c=1/0,u=1,m=t[l],p=m.filter((function(t){return t>0}));if(p.length>=s){var y=Math.floor(s),w=s-y;y>0?(o[l]=p[y-1],w>g&&(o[l]+=w*(p[y]-p[y-1]))):o[l]=w*p[0]}else p.length>0&&(o[l]=d.max(p));for(var b=0;b<n;b++){for(var v=0,C=1;C<t[l].length;C++){var S=t[l][C]-o[l];v+=S>0?Math.exp(-S/u):1}if(Math.abs(v-r)<g)break;v>r?u=(h+(c=u))/2:(h=u,c===1/0?u*=2:u=(h+c)/2)}if(a[l]=u,o[l]>0){var M=d.mean(m);a[l]<f*M&&(a[l]=f*M)}else{var A=d.mean(t.map(d.mean));a[l]<f*A&&(a[l]=f*A)}}return{sigmas:a,rhos:o}},t.prototype.computeMembershipStrengths=function(t,e,s,n){for(var i=t.length,r=t[0].length,o=d.zeros(i*r),a=d.zeros(i*r),l=d.zeros(i*r),h=0;h<i;h++)for(var c=0;c<r;c++){var u=0;-1!==t[h][c]&&(u=t[h][c]===h?0:e[h][c]-n[h]<=0?1:Math.exp(-(e[h][c]-n[h])/s[h]),o[h*r+c]=h,a[h*r+c]=t[h][c],l[h*r+c]=u)}return{rows:o,cols:a,vals:l}},t.prototype.initializeSimplicialSetEmbedding=function(){for(var t=this,e=this.getNEpochs(),s=this.nComponents,n=this.graph.getValues(),i=0,r=0;r<n.length;r++){var o=n[r];i<n[r]&&(i=o)}var a=this.graph.map((function(t){return t<i/e?0:t}));this.embedding=d.zeros(a.nRows).map((function(){return d.zeros(s).map((function(){return 20*d.tauRand(t.random)-10}))}));var l=[],h=[],c=[],u=a.getAll();for(r=0;r<u.length;r++){var m=u[r];m.value&&(l.push(m.value),c.push(m.row),h.push(m.col))}return{head:h,tail:c,epochsPerSample:this.makeEpochsPerSample(l,e)}},t.prototype.makeEpochsPerSample=function(t,e){var s=d.filled(t.length,-1),n=d.max(t),i=t.map((function(t){return t/n*e}));return i.forEach((function(t,n){t>0&&(s[n]=e/i[n])})),s},t.prototype.assignOptimizationStateParameters=function(t){Object.assign(this.optimizationState,t)},t.prototype.prepareForOptimizationLoop=function(){var t=this,e=t.repulsionStrength,s=t.learningRate,n=t.negativeSampleRate,i=this.optimizationState,r=i.epochsPerSample,a=i.headEmbedding,l=i.tailEmbedding,h=a[0].length,c=a.length===l.length,u=r.map((function(t){return t/n})),m=o(u),d=o(r);this.assignOptimizationStateParameters({epochOfNextSample:d,epochOfNextNegativeSample:m,epochsPerNegativeSample:u,moveOther:c,initialAlpha:s,alpha:s,gamma:e,dim:h})},t.prototype.initializeOptimization=function(){var t=this.embedding,e=this.embedding,s=this.optimizationState,n=s.head,i=s.tail,r=s.epochsPerSample,o=this.getNEpochs(),a=this.graph.nCols,l=S(this.spread,this.minDist),h=l.a,c=l.b;this.assignOptimizationStateParameters({headEmbedding:t,tailEmbedding:e,head:n,tail:i,epochsPerSample:r,a:h,b:c,nEpochs:o,nVertices:a})},t.prototype.optimizeLayoutStep=function(t){for(var e=this.optimizationState,s=e.head,n=e.tail,i=e.headEmbedding,r=e.tailEmbedding,o=e.epochsPerSample,a=e.epochOfNextSample,l=e.epochOfNextNegativeSample,h=e.epochsPerNegativeSample,c=e.moveOther,u=e.initialAlpha,m=e.alpha,p=e.gamma,g=e.a,f=e.b,y=e.dim,w=e.nEpochs,b=e.nVertices,S=0;S<o.length;S++)if(!(a[S]>t)){var M=s[S],A=n[S],T=i[M],E=r[A],x=C(T,E),N=0;x>0&&(N=-2*g*f*Math.pow(x,f-1),N/=g*Math.pow(x,f)+1);for(var L=0;L<y;L++){var I=v(N*(T[L]-E[L]),4);T[L]+=I*m,c&&(E[L]+=-I*m)}a[S]+=o[S];for(var _=Math.floor((t-l[S])/h[S]),R=0;R<_;R++){var O=d.tauRandInt(b,this.random),k=r[O],P=C(T,k),G=0;if(P>0)G=2*p*f,G/=(.001+P)*(g*Math.pow(P,f)+1);else if(M===O)continue;for(L=0;L<y;L++)I=4,G>0&&(I=v(G*(T[L]-k[L]),4)),T[L]+=I*m}l[S]+=_*h[S]}return e.alpha=u*(1-t/w),e.currentEpoch+=1,i},t.prototype.optimizeLayoutAsync=function(t){var e=this;return void 0===t&&(t=function(){return!0}),new Promise((function(s,r){var o=function(){return n(e,void 0,void 0,(function(){var e,n,a,l,h,c;return i(this,(function(i){try{if(e=this.optimizationState,n=e.nEpochs,a=e.currentEpoch,this.embedding=this.optimizeLayoutStep(a),l=this.optimizationState.currentEpoch,h=!1===t(l),c=l===n,h||c)return[2,s(c)];setTimeout((function(){return o()}),0)}catch(t){r(t)}return[2]}))}))};setTimeout((function(){return o()}),0)}))},t.prototype.optimizeLayout=function(t){void 0===t&&(t=function(){return!0});for(var e=!1,s=[];!e;){var n=this.optimizationState,i=n.nEpochs,r=n.currentEpoch;s=this.optimizeLayoutStep(r);var o=this.optimizationState.currentEpoch,a=!1===t(o);e=o===i||a}return s},t.prototype.getNEpochs=function(){var t=this.graph;if(this.nEpochs>0)return this.nEpochs;var e=t.nRows;return e<=2500?500:e<=5e3?400:e<=7500?300:200},t}();function w(t,e){for(var s=0,n=0;n<t.length;n++)s+=Math.pow(t[n]-e[n],2);return Math.sqrt(s)}e.UMAP=y,e.euclidean=w,e.cosine=function(t,e){for(var s=0,n=0,i=0,r=0;r<t.length;r++)s+=t[r]*e[r],n+=Math.pow(t[r],2),i+=Math.pow(e[r],2);return 0===n&&0===i?0:0===n||0===i?1:1-s/Math.sqrt(n*i)};var b=function(){this.currentEpoch=0,this.headEmbedding=[],this.tailEmbedding=[],this.head=[],this.tail=[],this.epochsPerSample=[],this.epochOfNextSample=[],this.epochOfNextNegativeSample=[],this.epochsPerNegativeSample=[],this.moveOther=!0,this.initialAlpha=1,this.alpha=1,this.gamma=1,this.a=1.5769434603113077,this.b=.8950608779109733,this.dim=2,this.nEpochs=500,this.nVertices=0};function v(t,e){return t>e?e:t<-e?-e:t}function C(t,e){for(var s=0,n=0;n<t.length;n++)s+=Math.pow(t[n]-e[n],2);return s}function S(t,e){var s=d.linear(0,3*t,300).map((function(t){return t<e?1:t})),n=d.zeros(s.length).map((function(n,i){return s[i]>=e?Math.exp(-(s[i]-e)/t):n})),i={x:s,y:n},o=p.default(i,(function(t){var e=r(t,2),s=e[0],n=e[1];return function(t){return 1/(1+s*Math.pow(t,2*n))}}),{damping:1.5,initialValues:[.5,.5],gradientDifference:.1,maxIterations:100,errorTolerance:.01}).parameterValues,a=r(o,2);return{a:a[0],b:a[1]}}function M(t,e,s,n){return void 0===s&&(s=1),void 0===n&&(n=5),t.map((function(t,i,r){return-1===e[i]||-1===e[r]?t*Math.exp(-s):e[i]!==e[r]?t*Math.exp(-n):t}))}function A(t){t=c.normalize(t,"max");var e=c.transpose(t),s=c.pairwiseMultiply(e,t);return t=c.add(t,c.subtract(e,s)),c.eliminateZeros(t)}function T(t,e,s){for(var n=d.zeros(t.length).map((function(t){return d.zeros(s[0].length)})),i=0;i<t.length;i++)for(var r=0;r<t[0].length;r++)for(var o=0;o<s[0].length;o++){var a=t[i][r];n[i][o]+=e[i][r]*s[a][o]}return n}e.findABParams=S,e.fastIntersection=M,e.resetLocalConnectivity=A,e.initTransform=T},4517:function(t,e){"use strict";var s=this&&this.__values||function(t){var e="function"==typeof Symbol&&t[Symbol.iterator],s=0;return e?e.call(t):{next:function(){return t&&s>=t.length&&(t=void 0),{value:t&&t[s++],done:!t}}}};function n(t,e){return Math.floor(e()*t)}function i(t){for(var e=[],s=0;s<t;s++)e.push(void 0);return e}function r(t,e){return i(t).map((function(){return e}))}function o(t){return r(t,0)}function a(t){return t.reduce((function(t,e){return t+e}))}Object.defineProperty(e,"__esModule",{value:!0}),e.tauRandInt=n,e.tauRand=function(t){return t()},e.norm=function(t){var e,n,i=0;try{for(var r=s(t),o=r.next();!o.done;o=r.next()){var a=o.value;i+=Math.pow(a,2)}}catch(t){e={error:t}}finally{try{o&&!o.done&&(n=r.return)&&n.call(r)}finally{if(e)throw e.error}}return Math.sqrt(i)},e.empty=i,e.range=function(t){return i(t).map((function(t,e){return e}))},e.filled=r,e.zeros=o,e.ones=function(t){return r(t,1)},e.linear=function(t,e,s){return i(s).map((function(n,i){return t+i*((e-t)/(s-1))}))},e.sum=a,e.mean=function(t){return a(t)/t.length},e.max=function(t){for(var e=0,s=0;s<t.length;s++)e=t[s]>e?t[s]:e;return e},e.max2d=function(t){for(var e=0,s=0;s<t.length;s++)for(var n=0;n<t[s].length;n++)e=t[s][n]>e?t[s][n]:e;return e},e.rejectionSample=function(t,e,s){for(var i=o(t),r=0;r<t;r++)for(var a=!0;a;){for(var l=n(e,s),h=!1,c=0;c<r;c++)if(l===i[c]){h=!0;break}h||(a=!1),i[r]=l}return i},e.reshape2d=function(t,e,s){var n=[],i=0;if(t.length!==e*s)throw new Error("Array dimensions must match input length.");for(var r=0;r<e;r++){for(var o=[],a=0;a<s;a++)o.push(t[i]),i+=1;n.push(o)}return n}},3336:t=>{"use strict";t.exports=$},976:t=>{"use strict";t.exports=DG},4469:t=>{"use strict";t.exports=grok},701:t=>{"use strict";t.exports=rxjs},3870:t=>{"use strict";t.exports=ui},6414:t=>{"use strict";t.exports=wu}},e={};function s(n){var i=e[n];if(void 0!==i)return i.exports;var r=e[n]={id:n,exports:{}};return t[n].call(r.exports,r,r.exports,s),r.exports}s.m=t,s.n=t=>{var e=t&&t.__esModule?()=>t.default:()=>t;return s.d(e,{a:e}),e},s.d=(t,e)=>{for(var n in e)s.o(e,n)&&!s.o(t,n)&&Object.defineProperty(t,n,{enumerable:!0,get:e[n]})},s.u=t=>t+".js",s.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(t){if("object"==typeof window)return window}}(),s.o=(t,e)=>Object.prototype.hasOwnProperty.call(t,e),s.r=t=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(t,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(t,"__esModule",{value:!0})},(()=>{var t;s.g.importScripts&&(t=s.g.location+"");var e=s.g.document;if(!t&&e&&(e.currentScript&&(t=e.currentScript.src),!t)){var n=e.getElementsByTagName("script");if(n.length)for(var i=n.length-1;i>-1&&!t;)t=n[i--].src}if(!t)throw new Error("Automatic publicPath is not supported in this browser");t=t.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),s.p=t})(),s.b=document.baseURI||self.location.href,s.nc=void 0;var n=s(4941);bio=n})();
2
2
  //# sourceMappingURL=package.js.map