@datagrok/bio 2.22.6 → 2.22.8

package/dist/package.js

@@ -1,8 +1,8 @@
-var bio;(()=>{var t={8924:(t,e,n)=>{"use strict";var i=n(7362);class o extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,o)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,o)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new o({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in o.aaSynonyms?o.aaSynonyms[t]:t;return super.get(e)}}o.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return o.GrokGroups;case"lesk":return o.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,n="",i="";for(const o of t)"("==o?e++:")"==o?e--:e?n+=o:i+=o;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(t="",e="grok"){const n=this.getPalette(e);let[i,o]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,o=o.length>6?`${o.slice(0,3)}...`:o,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in n?[n.get(e),e,o,1]:[this.undefinedColor,i,o,1]}if("d"==t[0]&&t[1]in n&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in n?[n.get(e),e,o,2]:[this.undefinedColor,i,o,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in n?[n.get(e),e,o,3]:[this.undefinedColor,i,o,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in n?[n.get(e),e,o,4]:[this.undefinedColor,i,o,4]}return[this.undefinedColor,i,o,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(t,e,n)=>{"use strict";n.d(e,{j:()=>o});var i=n(6082);async function o(){const t=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===t.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await t[0].prepare().call()).getOutputParamValue()}},3599:(t,e,n)=>{"use strict";n.d(e,{o:()=>i.o});var i=n(6869)},9124:(t,e,n)=>{"use strict";n.d(e,{b2:()=>r,fA:()=>s});var i=n(7389),o=n(6082);async function r(){const t="Helm",e=o.Func.find({package:t,name:"getHelmHelper"});if(0===e.length)throw new Error(`Package '${t}' must be installed for HelmHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}function s(t,e){if(!t)throw new Error("Argument 'a' of type Atom or HelmType is mandatory.");let n,i;const o=t;return"ATOM"===o.T?(n=o.biotype(),i=o.elem):(n=t,i=e),[n,i]}o.JsInputBase,Error,i.input.helmAsync=async function(t,e){return(await r()).createHelmInput(t,e)}},8438:(t,e,n)=>{"use strict";function i(t){return t.startsWith("[")&&t.endsWith("]")?t.slice(1,-1):t}n.d(e,{D:()=>i})},8123:(t,e,n)=>{"use strict";n.d(e,{u:()=>i});const i={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M  RGP",V2K_A_LINE:"A  ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:"  0  0  0  0  0  0            999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M  V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M  V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M  V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M  V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M  V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M  V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M  V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M  V30 ",V3K_END:"M  END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:{polymerType:"RNA",symbol:"d"},RIBOSE:{polymerType:"RNA",symbol:"r"},PHOSPHATE:{polymerType:"RNA",symbol:"p"},OXYGEN:"O",HYDROGEN:"H"}},4356:(t,e,n)=>{"use strict";n.d(e,{Eu:()=>a,ub:()=>s});var i=n(4328);const o="Libraries";let r=Promise.resolve();async function s(){let t;return r=r.then((async()=>{const e=i.userSettings.getValue(o,"Settings",!0);t=e?JSON.parse(e):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},t.exclude=t.exclude instanceof Array?t.exclude:[],t.explicit=t.explicit instanceof Array?t.explicit:[],t.duplicateMonomerPreferences=t.duplicateMonomerPreferences instanceof Object?t.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await r,t}async function a(t){r=r.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),i.userSettings.add(o,"Settings",JSON.stringify(t),!0)})),await r}},5553:(t,e,n)=>{"use strict";n.d(e,{Qc:()=>A,WN:()=>S});var i=n(1991),o=n.n(i);const r="object"==typeof performance&&performance&&"function"==typeof performance.now?performance:Date,s=new Set,a="object"==typeof process&&process?process:{},l=(t,e,n,i)=>{"function"==typeof a.emitWarning?a.emitWarning(t,e,n,i):console.error(`[${n}] ${e}: ${t}`)};let c=globalThis.AbortController,h=globalThis.AbortSignal;if(void 0===c){h=class{onabort;_onabort=[];reason;aborted=!1;addEventListener(t,e){this._onabort.push(e)}},c=class{constructor(){e()}signal=new h;abort(t){if(!this.signal.aborted){this.signal.reason=t,this.signal.aborted=!0;for(const e of this.signal._onabort)e(t);this.signal.onabort?.(t)}}};let t="1"!==a.env?.LRU_CACHE_IGNORE_AC_WARNING;const e=()=>{t&&(t=!1,l("AbortController is not defined. If using lru-cache in node 14, load an AbortController polyfill from the `node-abort-controller` package. A minimal polyfill is provided for use by LRUCache.fetch(), but it should not be relied upon in other contexts (eg, passing it to other APIs that use AbortController/AbortSignal might have undesirable effects). You may disable this with LRU_CACHE_IGNORE_AC_WARNING=1 in the env.","NO_ABORT_CONTROLLER","ENOTSUP",e))}}Symbol("type");const u=t=>t&&t===Math.floor(t)&&t>0&&isFinite(t),d=t=>u(t)?t<=Math.pow(2,8)?Uint8Array:t<=Math.pow(2,16)?Uint16Array:t<=Math.pow(2,32)?Uint32Array:t<=Number.MAX_SAFE_INTEGER?p:null:null;class p extends Array{constructor(t){super(t),this.fill(0)}}class m{heap;length;static#t=!1;static create(t){const e=d(t);if(!e)return[];m.#t=!0;const n=new m(t,e);return m.#t=!1,n}constructor(t,e){if(!m.#t)throw new TypeError("instantiate Stack using Stack.create(n)");this.heap=new e(t),this.length=0}push(t){this.heap[this.length++]=t}pop(){return this.heap[--this.length]}}class f{#e;#n;#i;#o;#r;#s;ttl;ttlResolution;ttlAutopurge;updateAgeOnGet;updateAgeOnHas;allowStale;noDisposeOnSet;noUpdateTTL;maxEntrySize;sizeCalculation;noDeleteOnFetchRejection;noDeleteOnStaleGet;allowStaleOnFetchAbort;allowStaleOnFetchRejection;ignoreFetchAbort;#a;#l;#c;#h;#u;#d;#p;#m;#f;#g;#y;#b;#v;#w;#C;#A;#S;static unsafeExposeInternals(t){return{starts:t.#v,ttls:t.#w,sizes:t.#b,keyMap:t.#c,keyList:t.#h,valList:t.#u,next:t.#d,prev:t.#p,get head(){return t.#m},get tail(){return t.#f},free:t.#g,isBackgroundFetch:e=>t.#x(e),backgroundFetch:(e,n,i,o)=>t.#E(e,n,i,o),moveToTail:e=>t.#T(e),indexes:e=>t.#M(e),rindexes:e=>t.#_(e),isStale:e=>t.#I(e)}}get max(){return this.#e}get maxSize(){return this.#n}get calculatedSize(){return this.#l}get size(){return this.#a}get fetchMethod(){return this.#r}get memoMethod(){return this.#s}get dispose(){return this.#i}get disposeAfter(){return this.#o}constructor(t){const{max:e=0,ttl:n,ttlResolution:i=1,ttlAutopurge:o,updateAgeOnGet:r,updateAgeOnHas:a,allowStale:c,dispose:h,disposeAfter:p,noDisposeOnSet:g,noUpdateTTL:y,maxSize:b=0,maxEntrySize:v=0,sizeCalculation:w,fetchMethod:C,memoMethod:A,noDeleteOnFetchRejection:S,noDeleteOnStaleGet:x,allowStaleOnFetchRejection:E,allowStaleOnFetchAbort:T,ignoreFetchAbort:M}=t;if(0!==e&&!u(e))throw new TypeError("max option must be a nonnegative integer");const _=e?d(e):Array;if(!_)throw new Error("invalid max value: "+e);if(this.#e=e,this.#n=b,this.maxEntrySize=v||this.#n,this.sizeCalculation=w,this.sizeCalculation){if(!this.#n&&!this.maxEntrySize)throw new TypeError("cannot set sizeCalculation without setting maxSize or maxEntrySize");if("function"!=typeof this.sizeCalculation)throw new TypeError("sizeCalculation set to non-function")}if(void 0!==A&&"function"!=typeof A)throw new TypeError("memoMethod must be a function if defined");if(this.#s=A,void 0!==C&&"function"!=typeof C)throw new TypeError("fetchMethod must be a function if specified");if(this.#r=C,this.#A=!!C,this.#c=new Map,this.#h=new Array(e).fill(void 0),this.#u=new Array(e).fill(void 0),this.#d=new _(e),this.#p=new _(e),this.#m=0,this.#f=0,this.#g=m.create(e),this.#a=0,this.#l=0,"function"==typeof h&&(this.#i=h),"function"==typeof p?(this.#o=p,this.#y=[]):(this.#o=void 0,this.#y=void 0),this.#C=!!this.#i,this.#S=!!this.#o,this.noDisposeOnSet=!!g,this.noUpdateTTL=!!y,this.noDeleteOnFetchRejection=!!S,this.allowStaleOnFetchRejection=!!E,this.allowStaleOnFetchAbort=!!T,this.ignoreFetchAbort=!!M,0!==this.maxEntrySize){if(0!==this.#n&&!u(this.#n))throw new TypeError("maxSize must be a positive integer if specified");if(!u(this.maxEntrySize))throw new TypeError("maxEntrySize must be a positive integer if specified");this.#L()}if(this.allowStale=!!c,this.noDeleteOnStaleGet=!!x,this.updateAgeOnGet=!!r,this.updateAgeOnHas=!!a,this.ttlResolution=u(i)||0===i?i:1,this.ttlAutopurge=!!o,this.ttl=n||0,this.ttl){if(!u(this.ttl))throw new TypeError("ttl must be a positive integer if specified");this.#N()}if(0===this.#e&&0===this.ttl&&0===this.#n)throw new TypeError("At least one of max, maxSize, or ttl is required");if(!this.ttlAutopurge&&!this.#e&&!this.#n){const t="LRU_CACHE_UNBOUNDED";(t=>!s.has(t))(t)&&(s.add(t),l("TTL caching without ttlAutopurge, max, or maxSize can result in unbounded memory consumption.","UnboundedCacheWarning",t,f))}}getRemainingTTL(t){return this.#c.has(t)?1/0:0}#N(){const t=new p(this.#e),e=new p(this.#e);this.#w=t,this.#v=e,this.#P=(n,i,o=r.now())=>{if(e[n]=0!==i?o:0,t[n]=i,0!==i&&this.ttlAutopurge){const t=setTimeout((()=>{this.#I(n)&&this.#$(this.#h[n],"expire")}),i+1);t.unref&&t.unref()}},this.#R=n=>{e[n]=0!==t[n]?r.now():0},this.#k=(o,r)=>{if(t[r]){const s=t[r],a=e[r];if(!s||!a)return;o.ttl=s,o.start=a,o.now=n||i();const l=o.now-a;o.remainingTTL=s-l}};let n=0;const i=()=>{const t=r.now();if(this.ttlResolution>0){n=t;const e=setTimeout((()=>n=0),this.ttlResolution);e.unref&&e.unref()}return t};this.getRemainingTTL=o=>{const r=this.#c.get(o);if(void 0===r)return 0;const s=t[r],a=e[r];return s&&a?s-((n||i())-a):1/0},this.#I=o=>{const r=e[o],s=t[o];return!!s&&!!r&&(n||i())-r>s}}#R=()=>{};#k=()=>{};#P=()=>{};#I=()=>!1;#L(){const t=new p(this.#e);this.#l=0,this.#b=t,this.#O=e=>{this.#l-=t[e],t[e]=0},this.#H=(t,e,n,i)=>{if(this.#x(e))return 0;if(!u(n)){if(!i)throw new TypeError("invalid size value (must be positive integer). When maxSize or maxEntrySize is used, sizeCalculation or size must be set.");if("function"!=typeof i)throw new TypeError("sizeCalculation must be a function");if(n=i(e,t),!u(n))throw new TypeError("sizeCalculation return invalid (expect positive integer)")}return n},this.#G=(e,n,i)=>{if(t[e]=n,this.#n){const n=this.#n-t[e];for(;this.#l>n;)this.#F(!0)}this.#l+=t[e],i&&(i.entrySize=n,i.totalCalculatedSize=this.#l)}}#O=t=>{};#G=(t,e,n)=>{};#H=(t,e,n,i)=>{if(n||i)throw new TypeError("cannot set size without setting maxSize or maxEntrySize on cache");return 0};*#M({allowStale:t=this.allowStale}={}){if(this.#a)for(let e=this.#f;this.#D(e)&&(!t&&this.#I(e)||(yield e),e!==this.#m);)e=this.#p[e]}*#_({allowStale:t=this.allowStale}={}){if(this.#a)for(let e=this.#m;this.#D(e)&&(!t&&this.#I(e)||(yield e),e!==this.#f);)e=this.#d[e]}#D(t){return void 0!==t&&this.#c.get(this.#h[t])===t}*entries(){for(const t of this.#M())void 0===this.#u[t]||void 0===this.#h[t]||this.#x(this.#u[t])||(yield[this.#h[t],this.#u[t]])}*rentries(){for(const t of this.#_())void 0===this.#u[t]||void 0===this.#h[t]||this.#x(this.#u[t])||(yield[this.#h[t],this.#u[t]])}*keys(){for(const t of this.#M()){const e=this.#h[t];void 0===e||this.#x(this.#u[t])||(yield e)}}*rkeys(){for(const t of this.#_()){const e=this.#h[t];void 0===e||this.#x(this.#u[t])||(yield e)}}*values(){for(const t of this.#M())void 0===this.#u[t]||this.#x(this.#u[t])||(yield this.#u[t])}*rvalues(){for(const t of this.#_())void 0===this.#u[t]||this.#x(this.#u[t])||(yield this.#u[t])}[Symbol.iterator](){return this.entries()}[Symbol.toStringTag]="LRUCache";find(t,e={}){for(const n of this.#M()){const i=this.#u[n],o=this.#x(i)?i.__staleWhileFetching:i;if(void 0!==o&&t(o,this.#h[n],this))return this.get(this.#h[n],e)}}forEach(t,e=this){for(const n of this.#M()){const i=this.#u[n],o=this.#x(i)?i.__staleWhileFetching:i;void 0!==o&&t.call(e,o,this.#h[n],this)}}rforEach(t,e=this){for(const n of this.#_()){const i=this.#u[n],o=this.#x(i)?i.__staleWhileFetching:i;void 0!==o&&t.call(e,o,this.#h[n],this)}}purgeStale(){let t=!1;for(const e of this.#_({allowStale:!0}))this.#I(e)&&(this.#$(this.#h[e],"expire"),t=!0);return t}info(t){const e=this.#c.get(t);if(void 0===e)return;const n=this.#u[e],i=this.#x(n)?n.__staleWhileFetching:n;if(void 0===i)return;const o={value:i};if(this.#w&&this.#v){const t=this.#w[e],n=this.#v[e];if(t&&n){const e=t-(r.now()-n);o.ttl=e,o.start=Date.now()}}return this.#b&&(o.size=this.#b[e]),o}dump(){const t=[];for(const e of this.#M({allowStale:!0})){const n=this.#h[e],i=this.#u[e],o=this.#x(i)?i.__staleWhileFetching:i;if(void 0===o||void 0===n)continue;const s={value:o};if(this.#w&&this.#v){s.ttl=this.#w[e];const t=r.now()-this.#v[e];s.start=Math.floor(Date.now()-t)}this.#b&&(s.size=this.#b[e]),t.unshift([n,s])}return t}load(t){this.clear();for(const[e,n]of t){if(n.start){const t=Date.now()-n.start;n.start=r.now()-t}this.set(e,n.value,n)}}set(t,e,n={}){if(void 0===e)return this.delete(t),this;const{ttl:i=this.ttl,start:o,noDisposeOnSet:r=this.noDisposeOnSet,sizeCalculation:s=this.sizeCalculation,status:a}=n;let{noUpdateTTL:l=this.noUpdateTTL}=n;const c=this.#H(t,e,n.size||0,s);if(this.maxEntrySize&&c>this.maxEntrySize)return a&&(a.set="miss",a.maxEntrySizeExceeded=!0),this.#$(t,"set"),this;let h=0===this.#a?void 0:this.#c.get(t);if(void 0===h)h=0===this.#a?this.#f:0!==this.#g.length?this.#g.pop():this.#a===this.#e?this.#F(!1):this.#a,this.#h[h]=t,this.#u[h]=e,this.#c.set(t,h),this.#d[this.#f]=h,this.#p[h]=this.#f,this.#f=h,this.#a++,this.#G(h,c,a),a&&(a.set="add"),l=!1;else{this.#T(h);const n=this.#u[h];if(e!==n){if(this.#A&&this.#x(n)){n.__abortController.abort(new Error("replaced"));const{__staleWhileFetching:e}=n;void 0===e||r||(this.#C&&this.#i?.(e,t,"set"),this.#S&&this.#y?.push([e,t,"set"]))}else r||(this.#C&&this.#i?.(n,t,"set"),this.#S&&this.#y?.push([n,t,"set"]));if(this.#O(h),this.#G(h,c,a),this.#u[h]=e,a){a.set="replace";const t=n&&this.#x(n)?n.__staleWhileFetching:n;void 0!==t&&(a.oldValue=t)}}else a&&(a.set="update")}if(0===i||this.#w||this.#N(),this.#w&&(l||this.#P(h,i,o),a&&this.#k(a,h)),!r&&this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#o?.(...e)}return this}pop(){try{for(;this.#a;){const t=this.#u[this.#m];if(this.#F(!0),this.#x(t)){if(t.__staleWhileFetching)return t.__staleWhileFetching}else if(void 0!==t)return t}}finally{if(this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#o?.(...e)}}}#F(t){const e=this.#m,n=this.#h[e],i=this.#u[e];return this.#A&&this.#x(i)?i.__abortController.abort(new Error("evicted")):(this.#C||this.#S)&&(this.#C&&this.#i?.(i,n,"evict"),this.#S&&this.#y?.push([i,n,"evict"])),this.#O(e),t&&(this.#h[e]=void 0,this.#u[e]=void 0,this.#g.push(e)),1===this.#a?(this.#m=this.#f=0,this.#g.length=0):this.#m=this.#d[e],this.#c.delete(n),this.#a--,e}has(t,e={}){const{updateAgeOnHas:n=this.updateAgeOnHas,status:i}=e,o=this.#c.get(t);if(void 0!==o){const t=this.#u[o];if(this.#x(t)&&void 0===t.__staleWhileFetching)return!1;if(!this.#I(o))return n&&this.#R(o),i&&(i.has="hit",this.#k(i,o)),!0;i&&(i.has="stale",this.#k(i,o))}else i&&(i.has="miss");return!1}peek(t,e={}){const{allowStale:n=this.allowStale}=e,i=this.#c.get(t);if(void 0===i||!n&&this.#I(i))return;const o=this.#u[i];return this.#x(o)?o.__staleWhileFetching:o}#E(t,e,n,i){const o=void 0===e?void 0:this.#u[e];if(this.#x(o))return o;const r=new c,{signal:s}=n;s?.addEventListener("abort",(()=>r.abort(s.reason)),{signal:r.signal});const a={signal:r.signal,options:n,context:i},l=(i,o=!1)=>{const{aborted:s}=r.signal,l=n.ignoreFetchAbort&&void 0!==i;if(n.status&&(s&&!o?(n.status.fetchAborted=!0,n.status.fetchError=r.signal.reason,l&&(n.status.fetchAbortIgnored=!0)):n.status.fetchResolved=!0),s&&!l&&!o)return h(r.signal.reason);const c=u;return this.#u[e]===u&&(void 0===i?c.__staleWhileFetching?this.#u[e]=c.__staleWhileFetching:this.#$(t,"fetch"):(n.status&&(n.status.fetchUpdated=!0),this.set(t,i,a.options))),i},h=i=>{const{aborted:o}=r.signal,s=o&&n.allowStaleOnFetchAbort,a=s||n.allowStaleOnFetchRejection,l=a||n.noDeleteOnFetchRejection,c=u;if(this.#u[e]===u&&(l&&void 0!==c.__staleWhileFetching?s||(this.#u[e]=c.__staleWhileFetching):this.#$(t,"fetch")),a)return n.status&&void 0!==c.__staleWhileFetching&&(n.status.returnedStale=!0),c.__staleWhileFetching;if(c.__returned===c)throw i};n.status&&(n.status.fetchDispatched=!0);const u=new Promise(((e,i)=>{const s=this.#r?.(t,o,a);s&&s instanceof Promise&&s.then((t=>e(void 0===t?void 0:t)),i),r.signal.addEventListener("abort",(()=>{n.ignoreFetchAbort&&!n.allowStaleOnFetchAbort||(e(void 0),n.allowStaleOnFetchAbort&&(e=t=>l(t,!0)))}))})).then(l,(t=>(n.status&&(n.status.fetchRejected=!0,n.status.fetchError=t),h(t)))),d=Object.assign(u,{__abortController:r,__staleWhileFetching:o,__returned:void 0});return void 0===e?(this.set(t,d,{...a.options,status:void 0}),e=this.#c.get(t)):this.#u[e]=d,d}#x(t){if(!this.#A)return!1;const e=t;return!!e&&e instanceof Promise&&e.hasOwnProperty("__staleWhileFetching")&&e.__abortController instanceof c}async fetch(t,e={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:o=this.noDeleteOnStaleGet,ttl:r=this.ttl,noDisposeOnSet:s=this.noDisposeOnSet,size:a=0,sizeCalculation:l=this.sizeCalculation,noUpdateTTL:c=this.noUpdateTTL,noDeleteOnFetchRejection:h=this.noDeleteOnFetchRejection,allowStaleOnFetchRejection:u=this.allowStaleOnFetchRejection,ignoreFetchAbort:d=this.ignoreFetchAbort,allowStaleOnFetchAbort:p=this.allowStaleOnFetchAbort,context:m,forceRefresh:f=!1,status:g,signal:y}=e;if(!this.#A)return g&&(g.fetch="get"),this.get(t,{allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:o,status:g});const b={allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:o,ttl:r,noDisposeOnSet:s,size:a,sizeCalculation:l,noUpdateTTL:c,noDeleteOnFetchRejection:h,allowStaleOnFetchRejection:u,allowStaleOnFetchAbort:p,ignoreFetchAbort:d,status:g,signal:y};let v=this.#c.get(t);if(void 0===v){g&&(g.fetch="miss");const e=this.#E(t,v,b,m);return e.__returned=e}{const e=this.#u[v];if(this.#x(e)){const t=n&&void 0!==e.__staleWhileFetching;return g&&(g.fetch="inflight",t&&(g.returnedStale=!0)),t?e.__staleWhileFetching:e.__returned=e}const o=this.#I(v);if(!f&&!o)return g&&(g.fetch="hit"),this.#T(v),i&&this.#R(v),g&&this.#k(g,v),e;const r=this.#E(t,v,b,m),s=void 0!==r.__staleWhileFetching&&n;return g&&(g.fetch=o?"stale":"refresh",s&&o&&(g.returnedStale=!0)),s?r.__staleWhileFetching:r.__returned=r}}async forceFetch(t,e={}){const n=await this.fetch(t,e);if(void 0===n)throw new Error("fetch() returned undefined");return n}memo(t,e={}){const n=this.#s;if(!n)throw new Error("no memoMethod provided to constructor");const{context:i,forceRefresh:o,...r}=e,s=this.get(t,r);if(!o&&void 0!==s)return s;const a=n(t,s,{options:r,context:i});return this.set(t,a,r),a}get(t,e={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:o=this.noDeleteOnStaleGet,status:r}=e,s=this.#c.get(t);if(void 0!==s){const e=this.#u[s],a=this.#x(e);return r&&this.#k(r,s),this.#I(s)?(r&&(r.get="stale"),a?(r&&n&&void 0!==e.__staleWhileFetching&&(r.returnedStale=!0),n?e.__staleWhileFetching:void 0):(o||this.#$(t,"expire"),r&&n&&(r.returnedStale=!0),n?e:void 0)):(r&&(r.get="hit"),a?e.__staleWhileFetching:(this.#T(s),i&&this.#R(s),e))}r&&(r.get="miss")}#B(t,e){this.#p[e]=t,this.#d[t]=e}#T(t){t!==this.#f&&(t===this.#m?this.#m=this.#d[t]:this.#B(this.#p[t],this.#d[t]),this.#B(this.#f,t),this.#f=t)}delete(t){return this.#$(t,"delete")}#$(t,e){let n=!1;if(0!==this.#a){const i=this.#c.get(t);if(void 0!==i)if(n=!0,1===this.#a)this.#V(e);else{this.#O(i);const n=this.#u[i];if(this.#x(n)?n.__abortController.abort(new Error("deleted")):(this.#C||this.#S)&&(this.#C&&this.#i?.(n,t,e),this.#S&&this.#y?.push([n,t,e])),this.#c.delete(t),this.#h[i]=void 0,this.#u[i]=void 0,i===this.#f)this.#f=this.#p[i];else if(i===this.#m)this.#m=this.#d[i];else{const t=this.#p[i];this.#d[t]=this.#d[i];const e=this.#d[i];this.#p[e]=this.#p[i]}this.#a--,this.#g.push(i)}}if(this.#S&&this.#y?.length){const t=this.#y;let e;for(;e=t?.shift();)this.#o?.(...e)}return n}clear(){return this.#V("delete")}#V(t){for(const e of this.#_({allowStale:!0})){const n=this.#u[e];if(this.#x(n))n.__abortController.abort(new Error("deleted"));else{const i=this.#h[e];this.#C&&this.#i?.(n,i,t),this.#S&&this.#y?.push([n,i,t])}}if(this.#c.clear(),this.#u.fill(void 0),this.#h.fill(void 0),this.#w&&this.#v&&(this.#w.fill(0),this.#v.fill(0)),this.#b&&this.#b.fill(0),this.#m=0,this.#f=0,this.#g.length=0,this.#l=0,this.#a=0,this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#o?.(...e)}}}function g(t){window.$monomerHover=t}var y=n(2003),b=n(6077),v=n(3561),w=n(9235);const C="MonomerHoverLinks";async function A(t,e,n,i,r,s=!1){const a=i.getSeqHandler(t),l=a.alphabet==y.YI.RNA||a.alphabet==y.YI.DNA,c=a.isHelm()&&l,h=!a.isHelm()&&l,u=t=>null==t?null:c?s?t:Math.floor(t/3):h&&s?3*t+1:t,d=s?await i.getHelmToMolfileConverter(n):null,p=new f({max:100});function m(t,e){const a=t.get(e);if(null==a)return null;let l=p.get(a);return l||p.set(a,l=function(t,e){const a=i.getSeqHandler(t);if(s){const t=a.getHelm(e);return i.helmToAtomicLevelSingle(t,d,!1,!1).monomers}{const t=a.getSplitted(e),i=a.defaultBiotype,s=o().count(0).take(t.length).map((e=>({position:e,symbol:t.getCanonical(e),biotype:i}))).toArray(),l=a.alphabet,c=l==y.YI.RNA||l==y.YI.DNA?"RNA":"PEPTIDE",h=(0,b.eM)([s],c,l,n,r);return(0,v.gU)(s,h,l,c).monomers}}(t,e)),l}const A={targetCol:e,handler:(e,i,o)=>{const r=o.grid,s=e.tableRowIndex,a=e.gridRow,l=r.cell(o.name,a),c=null!==(h=window.$monomerHover)&&void 0!==h?h:null;var h;if(!c||c&&(c.dataFrameId!=t.dataFrame.id||c.gridRowIdx!=a||c.seqColName!=t.name||c.seqPosition!=i?.position)){if(c&&(g(null),c.gridCell.render()),!i)return g(null),!0;g({gridCell:l,dataFrameId:t.dataFrame.id,gridRowIdx:a,seqColName:t.name,seqPosition:u(i?.position)??-1,getSubstruct:()=>{if(!i||"*"===i.symbol)return;const e=m(t,s);if(!e)return;const o=e.get(u(i?.position));return o?(0,w.H)([o],n):{atoms:[],bonds:[],highlightAtomColors:[],highlightBondColors:[]}}}),l.render()}return!0},getSubstruct:i=>{if("true"!=e.getTag(".sequence-src-highlight-monomers"))return;if(null==i)return;if(!t.get(i))return;const o=m(t,i);return o?(0,w.H)(o.values(),n):void 0}};return function(t,e){let n=t[C];n||(n=t[C]=[]),n.push(e),t[C]=n}(t.temp,A),function(t,e){let n=t["substruct-providers"];n||(n=t["substruct-providers"]=[]),n.push(e),t["substruct-providers"]=n}(e.temp,A),A}function S(t,e){try{const n=t.tableColumn;if(!n)return;const i=function(t){return t.temp[C]??[]}(n);for(let n=i.length-1;n>=0;--n){const o=i[n],r=t.grid.col(o.targetCol.name);if(r&&!o.handler(t,e,r))break}}catch(t){console.error(t)}}},6718:(t,e,n)=>{"use strict";n.d(e,{A7:()=>p,pj:()=>h,uL:()=>u,uX:()=>c});var i=n(6082),o=n(4328),r=n(6295),s=n(3151),a=n(3077),l=n(439);function c(t){const e=[];for(let n=0;n<t.rowCount;n++){const i={};Object.keys(s.Ec).forEach((e=>{if("symbol"===e){const o=t.get(s.Ec[e],n);i[e]="."===o?t.get(s.yw,n):o}else if("rgroups"===e){const o=t.get(s.Ec[e],n).split("\n"),r=[];o.forEach((t=>{const e={},n=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===n?"H":"OH",e.label=`R${i}`,r.push(e)})),i[e]=r}else s.Ec[e]&&(i[e]=t.get(s.Ec[e],n))})),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),e.push(i)}return e}async function h(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function u(t,e,n){t instanceof i.Column&&(t=(0,a.R)(t,n).columns.toList());const r=(await h()).getMonomerLib(),s=new Array(t.length),c=t[0].length,u=new Float32Array(c);for(let n=0;n<t.length;++n){const a=n<e.length?e.getCanonical(n):l._S,h=r.getMonomer("PEPTIDE",a)?.smiles??"",d=t[n],p=d.getRawData(),m=d.categories,f=m.indexOf("");if(s[n]={categories:m,data:p,emptyIndex:f},void 0===a)continue;const g=i.Column.fromStrings("smiles",m.map((t=>r.getMonomer("PEPTIDE",t)?.smiles??""))),y=(i.DataFrame.fromColumns([g]),await o.chem.getSimilarities(g,h)),b=y?y.getRawData():null;for(let t=0;t<c;++t){const e=p[t];a!==l._S&&e!==f?u[t]+=b[e]:a===l._S&&e===f&&(u[t]+=1)}}for(let n=0;n<u.length;++n){let o=u[n]/e.length;for(let r=0;r<t.length;++r){const t=s[r];if(r>=e.length&&t.data[n]!==t.emptyIndex||t.data[n]===t.emptyIndex&&r<e.length){o=i.FLOAT_NULL;break}}u[n]=o}return i.Column.fromFloat32Array("Similarity",u)}async function d(t){const e=(await h()).getMonomerLib(),n=[],r={},s=t.map((t=>e.getMonomer("PEPTIDE",t)?.smiles??"")),a=i.Column.fromStrings("smiles",s);for(let e=0;e<s.length;++e){r[t[e]]=e;const i=s[e],l=""===i?new Array(s.length).fill(0):(await o.chem.getSimilarities(a,i)).getRawData();l[e]=1,n[e]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:r}}async function p(t,e="Morgan"){const n=(await h()).getMonomerLib(),o=new Array(t.length).fill(0).map((()=>new Array(t.length).fill(0))),s={},a=t.map((t=>n.getMonomer("PEPTIDE",t)?.molfile||n.getMonomer("PEPTIDE",t)?.smiles||"")),l=i.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(t);const c=i.Column.fromStrings("smiles",a),u=(i.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:e}))?.entries);if(!u)return console.warn(`${e} Fingerprints could not be calculated for monomers from chem package.\n      falling back to Morgan fingerprints`),await d(t);for(let e=0;e<u.length;++e)if(o[e][e]=1,s[t[e]]=e,u[e])for(let t=e+1;t<u.length;++t)u[t]&&(o[e][t]=o[t][e]=(0,r.$1)(u[e],u[t]));return{scoringMatrix:o,alphabetIndexes:s}}},6197:(t,e,n)=>{"use strict";n.d(e,{Y:()=>o});var i=n(3599);function o(t){let e;switch(t){case i.o.BASE:case i.o.SUGAR:case i.o.LINKER:case i.o.NUCLEOTIDE:case"nucleotide":e="RNA";break;case i.o.AA:e="PEPTIDE";break;case i.o.CHEM:e="CHEM";break;case i.o.BLOB:e="BLOB";break;default:e="PEPTIDE",console.warn(`Unexpected HelmType '${t}'`)}return e}},9235:(t,e,n)=>{"use strict";n.d(e,{H:()=>c,R:()=>l});var i=n(6082),o=n(1991),r=n.n(o),s=n(330),a=n(3599);async function l(t,e,o,l,c,h,u){const d=t.length,p=t.dataFrame,m=Math.max(navigator.hardwareConcurrency-2,1),f=new Array(m).fill(null).map((()=>new Worker(new URL(n.p+n.u(455),n.b)))),g=d/m,y=new Array(m),b=h.getSeqHandler(t),v="RNA"==l?a.o.NUCLEOTIDE:a.o.AA,w=r().count(0).take(t.length).map((t=>{const e=b.getSplitted(t);return r().count(0).take(e.length).map((t=>({position:t,symbol:e.getCanonical(t),biotype:v}))).toArray()})).toArray();for(let t=0;t<m;t++){const n=f[t],i=Math.floor(t*g),r=t===m-1?d:Math.floor((t+1)*g);y[t]=new Promise((t=>{n.onmessage=e=>{t(e.data)}})),n.postMessage({seqList:w,monomersDict:e,alphabet:o,polymerType:l,start:i,end:r})}const C=[],A=[];await Promise.all(y).then((t=>{for(const e of t)C.push(...e.molfiles),A.push(...e.warnings)})),setTimeout((()=>{f.forEach((t=>{t.terminate()}))}),0);const S=(0,s.qj)(p,t.name),x=i.Column.fromType(i.COLUMN_TYPE.STRING,S,t.length).init((t=>C[t]?.molfile));return x.semType=i.SEMTYPE.MOLECULE,x.meta.units=i.UNITS.Molecule.MOLBLOCK,x.setTag(".sequence-src-col",t.name),{molCol:x,warnings:A}}function c(t,e){const n={},o={};for(const r of t){const t=e.getWebEditorMonomer(r.biotype,r.symbol).backgroundcolor,a=(0,s.vG)(t??i.Color.toRgb(i.Color.mouseOverRows))??[1,0,0,.7];for(const t of r.atoms)n[t]=a;for(const t of r.bonds)o[t]=a}return{atoms:Object.keys(n).map((t=>parseInt(t))),bonds:Object.keys(o).map((t=>parseInt(t))),highlightAtomColors:n,highlightBondColors:o}}},3561:(t,e,n)=>{"use strict";n.d(e,{Hb:()=>l,YN:()=>f,gU:()=>c});var i=n(8123),o=n(294),r=n(3151),s=n(439),a=n(6197);function l(t,e,n){const o=new Map;for(const a of t.getMonomerSymbolsByType(e)){const l=t.getMonomer(e,a);if("RNA"===e&&("Branch"===l.monomerType||n===s.YI.DNA&&l.symbol===i.u.DEOXYRIBOSE.symbol||n===s.YI.RNA&&l.symbol===i.u.RIBOSE.symbol||l.symbol===i.u.PHOSPHATE.symbol)||"PEPTIDE"===e&&"Branch"!==l.monomerType){const t={};r.f6.forEach((e=>{t[e]=l[e]})),o.set(l.symbol,t)}}return o}function c(t,e,n,r){if(0===t.length)return o.vF.createEmpty();const l=m,{atomCount:c,bondCount:u,needsCapping:p}=l(t,e,n,r),g=new Array(c),y=new Array(u);let b,v=null,w=null;"PEPTIDE"===r?b=h:(b=d,v=n===s.YI.DNA?(0,o.xb)(e,i.u.DEOXYRIBOSE):(0,o.xb)(e,i.u.RIBOSE),w=(0,o.xb)(e,i.u.PHOSPHATE));const C={i:0,nodeShift:0,bondShift:0,backbonePositionShift:new Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},A={sugar:v,phosphate:w,seqLength:t.length,atomCount:c,bondCount:u},S=new o.Cg,x=[];let E,T=0;for(C.i=0;C.i<A.seqLength;++C.i){const n=t[C.i];if(n.symbol===s._S)continue;const i=(0,o.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)});E=i.terminalR2Atom;const r=C.nodeShift,l=C.bondShift;b(i,g,y,C,A),i.stereoAtoms?.forEach((t=>x.push(t+T))),T+=i.atoms.x.length;const c=C.nodeShift-r,h=new Array(c);for(let t=0;t<c;++t)h[t]=r+t;const u=C.bondShift-l,d=new Array(u);for(let t=0;t<u;++t)d[t]=l+t;S.set(C.i,{biotype:n.biotype,symbol:n.symbol,atoms:h,bonds:d})}p&&function(t,e,n,o,r=i.u.OXYGEN){const s=n.nodeShift+1;t[o.atomCount]=i.u.V3K_BEGIN_DATA_LINE+s+" "+(r??i.u.OXYGEN)+" "+f(n.backbonePositionShift[0])+" "+n.flipFactor*f(n.backbonePositionShift[1])+" 0.000000 0\n";const a=n.backboneAttachNode,l=s;e[o.bondCount]=i.u.V3K_BEGIN_DATA_LINE+n.bondShift+" 1 "+a+" "+l+"\n"}(g,y,C,A,E??i.u.OXYGEN);const M=i.u.V3K_BEGIN_COUNTS_LINE+c+" "+u+i.u.V3K_COUNTS_LINE_ENDING;let _="";return _+=i.u.V3K_HEADER_FIRST_LINE,_+=i.u.V3K_HEADER_SECOND_LINE,_+=i.u.V3K_BEGIN_CTAB_BLOCK,_+=M,_+=i.u.V3K_BEGIN_ATOM_BLOCK,_+=g.join(""),_+=i.u.V3K_END_ATOM_BLOCK,_+=i.u.V3K_BEGIN_BOND_BLOCK,_+=y.join(""),_+=i.u.V3K_END_BOND_BLOCK,x.length>0&&(_+=function(t){const e=[];let n=`M  V30 MDLV30/STEABS ATOMS=(${t.length}`;for(let i=0;i<t.length;i++){const o=`${n} ${t[i]}`;o.length>76?(e.push(`${n} -\n`),n=`M  V30 ${t[i]}`):n=o,i===t.length-1&&e.push(`${n})\n`)}return`M  V30 BEGIN COLLECTION\n${e.join("")}M  V30 END COLLECTION\n`}(x)),_+=i.u.V3K_END_CTAB_BLOCK,_+=i.u.V3K_END,{molfile:_,monomers:S}}function h(t,e,n,i){i.flipFactor=(-1)**(i.i%2),u(t,e,n,i)}function u(t,e,n,o){!function(t,e,n){for(let o=0;o<t.atoms.atomTypes.length;++o){const r=n.nodeShift+o+1;e[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+t.atoms.atomTypes[o]+" "+f(n.backbonePositionShift[0]+t.atoms.x[o])+" "+f(n.backbonePositionShift[1]+n.flipFactor*t.atoms.y[o])+" "+t.atoms.kwargs[o]}}(t,e,o),p(t,n,o),function(t,e,n){if(0!==n.backboneAttachNode){const o=n.bondShift,r=n.backboneAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[n.bondShift-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+r+" "+s+"\n"}}(t,n,o),null!==t.meta.branchShift&&t.meta.terminalNodes.length>2&&function(t,e){e.branchAttachNode=e.nodeShift+t.meta.terminalNodes[2];for(let n=0;n<2;++n)e.branchPositionShift[n]=e.backbonePositionShift[n]+t.meta.branchShift[n]}(t,o),function(t,e){e.backboneAttachNode=e.nodeShift+t.meta.terminalNodes[1],e.bondShift+=t.bonds.atomPairs.length+1,e.nodeShift+=t.atoms.atomTypes.length,e.backbonePositionShift[0]+=t.meta.backboneShift?.[0]??0,e.backbonePositionShift[1]+=e.flipFactor*(t.meta.backboneShift?.[1]??0)}(t,o)}function d(t,e,n,o,r){if(0===o.i)u(r.sugar,e,n,o);else for(const t of[r.phosphate,r.sugar])u(t,e,n,o);!function(t,e,n,o){(function(t,e,n){for(let o=0;o<t.atoms.atomTypes.length;++o){const r=n.nodeShift+o+1;e[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+t.atoms.atomTypes[o]+" "+f(n.branchPositionShift[0]+t.atoms.x[o])+" "+f(n.branchPositionShift[1]+n.flipFactor*t.atoms.y[o])+" "+t.atoms.kwargs[o]}})(t,e,o),p(t,n,o),function(t,e,n){const o=n.bondShift,r=n.branchAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[o-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+r+" "+s+"\n"}(t,n,o);const r=o.bondShift,s=o.branchAttachNode,a=t.meta.terminalNodes[0]+o.nodeShift;n[r-1]=i.u.V3K_BEGIN_DATA_LINE+r+" 1 "+s+" "+a+"\n",o.bondShift+=t.bonds.atomPairs.length+1,o.nodeShift+=t.atoms.atomTypes.length}(t,e,n,o)}function p(t,e,n){for(let o=0;o<t.bonds.atomPairs.length;++o){const r=n.bondShift+o+1,s=t.bonds.atomPairs[o][0]+n.nodeShift,a=t.bonds.atomPairs[o][1]+n.nodeShift;let l="";if(t.bonds.bondConfiguration.has(o)){let e=t.bonds.bondConfiguration.get(o);n.flipFactor<0&&(e=1===e?3:1),l=" CFG="+e}const c=t.bonds.kwargs.has(o)?" "+t.bonds.kwargs.get(o):"";e[n.bondShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+t.bonds.bondTypes[o]+" "+s+" "+a+l+c+"\n"}}function m(t,e,n,r){let l=0,c=0,h=0,u=!0,d=null;for(const n of t)if(n.symbol!==s._S){if("*"==n.symbol)throw new Error("Gap canonical symbol is '', not '*");d=(0,o.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),l+=d.atoms.x.length,c+=d.bonds.bondTypes.length,h++}if("PEPTIDE"===r)l+=1,c+=h,h>0&&((d?.meta?.rNodes?.length??0)<2||d?.terminalR2Atom?.toLowerCase()===i.u.HYDROGEN.toLowerCase())&&(u=!1,l-=1,c-=1);else{const r=n===s.YI.DNA?(0,o.xb)(e,i.u.DEOXYRIBOSE):(0,o.xb)(e,i.u.RIBOSE),a=(0,o.xb)(e,i.u.PHOSPHATE);l+=(t.length-1)*a.atoms.x.length,l+=t.length*r.atoms.x.length,l+=1,c+=(t.length-1)*a.bonds.bondTypes.length,c+=t.length*r.bonds.bondTypes.length,c-=1,c+=3*t.length}return{atomCount:l,bondCount:c,needsCapping:u}}function f(t){return Math.round(i.u.PRECISION_FACTOR*t)/i.u.PRECISION_FACTOR}},6077:(t,e,n)=>{"use strict";n.d(e,{C4:()=>m,eM:()=>f});var i=n(4328),o=n(6082),r=n(1991),s=n.n(r),a=n(439),l=n(3561),c=n(9235),h=n(294),u=n(9192),d=n(330),p=n(8123);async function m(t,e,n,r,l){if(e.semType!==o.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${o.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let h=e;const p=r.getSeqHandler(e);let m,g;p.notation!==a.Hi.SEPARATOR&&(h=p.convert(a.Hi.SEPARATOR,"."),h.name=e.name);try{g=r.getSeqHandler(h).alphabet,m=(0,d.pz)(g)}catch(t){const[e,n]=(0,u.AP)(t);return{molCol:null,warnings:[e]}}const y=function(t,e){const n=t.length,o=new Array(n),r=e.getSeqHandler(t);let a=!1;const l=r.defaultBiotype;for(let t=0;t<n;++t){const e=r.getSplitted(t);a||(a=0===e.length),o[t]=s().count(0).take(e.length).filter((t=>!e.isGap(t))).map((t=>({position:t,biotype:l,symbol:e.getCanonical(t)}))).toArray()}return a&&i.shell.warning(`Some values in the "${t.name}" column are empty`),o}(h,r),b=f(y,m,g,n,l),v=h.length,w=await(0,c.R)(h,b,g,m,n,r,l);w.warnings.length>.05*v&&i.shell.warning(`Molfile conversion resulted in ${w.warnings.length} errors`);const C=o.Func.find({name:"convertToV3KViaOCL"})[0];if(C&&w.molCol)try{const t=w.molCol.toList(),e=await C.apply({mols:t});w.molCol.init((n=>e[n]?e[n]:t[n]))}catch(t){console.error(t)}return w}function f(t,e,n,i,o){const r=(0,l.Hb)(i,e,n),s={},c={value:null};if("RNA"===e){const t=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of t)g(s,n.symbol,r,o,e,c)}for(let n=0;n<t.length;++n){const i=t[n];for(const t of i){const n=t.symbol;if(""!==n)try{if("RNA"===e&&3===n.split(/\(|\)/).filter((t=>!!t)).length){const t=n.split(/\(|\)/)[1];g(s,t,r,o,e,c),s[e]?.[t]&&(s[e][n]=s[e][t])}else g(s,n,r,o,e,c)}catch(t){const e=t instanceof Error?t.message:t.toString(),i=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${e}\n${i}`),new Error(`Can't get monomer '${n}' from library: ${e}`)}}}return s}function g(t,e,n,i,o,r){const s={polymerType:o,symbol:e};if(!(0,h.bq)(t,s)){const a=function(t,e,n,i,o){if(e.has(t)){const s=e.get(t),a=function(t){const e=[];for(const n of t){let t=n.capGroupSmiles;t||(t=n.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,"").replace("OH","O").replace("Oh","O"),e.push(t)}return e}(s.rgroups),c=(r=s.molfile).includes("V3000")?function(t){const e=new Map,n=/M  V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(t));)i.index===n.lastIndex&&n.lastIndex++,e.set(parseInt(i[1]),parseInt(i[3]));return e}(r):function(t){const e=new Map;let n=t.indexOf(p.u.V2K_A_LINE,0),i=n;for(;-1!==n;){i=t.indexOf("\n",n);const o=parseInt(t.substring(n,i).replace(/^A\s+/,""));n=t.indexOf("R",i),i=t.indexOf("\n",n);const r=parseInt(t.substring(n,i).replace(/^R/,""));e.set(o,r),n=t.indexOf(p.u.V2K_A_LINE,i)}for(n=t.indexOf(p.u.V2K_RGP_LINE,0),i=t.indexOf("\n",n);-1!==n;){n+=p.u.V2K_RGP_SHIFT,i=t.indexOf("\n",n);const o=t.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<o.length;t+=2){if(e.has(o[t])&&e.get(o[t])!==o[t+1])throw new Error(`r-group index ${o[t]} has already been added with a different value`);e.set(o[t],o[t+1])}n=t.indexOf(p.u.V2K_RGP_LINE,i)}return e}(r),h=s.molfile.includes("V3000")?s.molfile:function(t,e){const n=e.get_mol(function(t){return t.split("\n").map((t=>{const e=t.indexOf(" R#  "),n=t.indexOf(" R   ");if(-1===e&&-1===n)return t;const i=-1!==e?e:n,o=t.split("");for(let t=i+5;t<o.length;t++)" "!==o[t]&&(o[t]="0");return o.join("")})).join("\n")}(t)),i=n.get_v3Kmolblock();return n.delete(),i}(function(t){let e=t.indexOf(p.u.V2K_A_LINE,0);-1===e&&(e=t.indexOf(p.u.V2K_RGP_LINE));const n=t.indexOf(p.u.V3K_END,e);return t.substring(0,e)+t.substring(n)}(s.molfile),n),u=function(t){let e=(t=t.replaceAll("\r","")).indexOf(p.u.V3K_BEGIN_COUNTS_LINE)+p.u.V3K_COUNTS_SHIFT,n=t.indexOf(" ",e+1);const i=parseInt(t.substring(e,n));return e=n+1,n=t.indexOf(" ",e+1),{atomCount:i,bondCount:parseInt(t.substring(e,n))}}(h),d=function(t,e){const n=new Array(e),i=new Float32Array(e),o=new Float32Array(e),r=new Array(e);let s=t.indexOf(p.u.V3K_BEGIN_ATOM_BLOCK);s=t.indexOf("\n",s);let a=s;for(let l=0;l<e;l++){s=t.indexOf(p.u.V3K_BEGIN_DATA_LINE,s)+p.u.V3K_IDX_SHIFT,a=t.indexOf(" ",s),s=a+1,a=t.indexOf(" ",s),n[l]=t.substring(s,a);const e=new Array(2);for(let n=0;n<2;++n)s=a+1,a=t.indexOf(" ",s),e[n]=parseFloat(t.substring(s,a));i[l]=e[0],o[l]=e[1],s=a,a=t.indexOf("\n",s)+1,r[l]=t.slice(s,a),s=a}return{atomTypes:n,x:i,y:o,kwargs:r}}(h,u.atomCount),m=function(t,e){const n=new Uint32Array(e),i=new Array(e),o=new Map,r=new Map;let s=t.indexOf(p.u.V3K_BEGIN_BOND_BLOCK);s=t.indexOf("\n",s);let a=s;for(let l=0;l<e;++l){const e=new Array(3);s=t.indexOf(p.u.V3K_BEGIN_DATA_LINE,a)+p.u.V3K_IDX_SHIFT,a=t.indexOf(" ",s);for(let n=0;n<3;++n)s=a+1,a=Math.min(t.indexOf("\n",s),t.indexOf(" ",s)),e[n]=parseInt(t.slice(s,a));n[l]=e[0],i[l]=e.slice(1);const c=t.indexOf("\n",s);let h=t.slice(a,c),u=h.indexOf(p.u.V3K_BOND_CONFIG);if(-1!==u){u=h.indexOf("=",u)+1;let t=h.indexOf(" ",u);-1===t&&(t=h.length);const e=parseInt(h.slice(u,t));o.set(l,e);const n=p.u.V3K_BOND_CONFIG+e.toString();h=h.replace(n,"")}h||r.set(l,h)}return{bondTypes:n,atomPairs:i,bondConfiguration:o,kwargs:r}}(h,u.bondCount),f=function(t,e,n,i){const o={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};if(n&&i&&[1,2].some((t=>!Array.from(i.values()).find((e=>e==t))))){const o=[1,2].find((t=>!Array.from(i.values()).find((e=>e==t)))),r=[1,2].find((t=>Array.from(i.values()).find((e=>e==t)))),s=Array.from(i.keys()).find((t=>i.get(t)===r))-1,a=t.x[s],l=t.y[s],c=e.atomPairs.find((t=>t.includes(s+1))).find((t=>t!==s+1))-1;let h=t.x.reduce(((e,n,i)=>{if(i===s)return e;if(i===c)return e;const o=t.y[i];return Math.sqrt((n-a)**2+(o-l)**2)>Math.sqrt((t.x[e]-a)**2+(t.y[e]-l)**2)?i:e}),-1);if(-1===h&&(h=t.x.length,t.x=new Float32Array([...t.x,-a]),t.y=new Float32Array([...t.y,-l]),t.atomTypes=[...t.atomTypes,"H"],t.kwargs=[...t.kwargs,""],e.atomPairs.push([c+1,h+1]),e.bondTypes=new Uint32Array([...e.bondTypes,1]),e.kwargs.set(e.atomPairs.length-1,"")),i.set(h+1,o),1===o)n.unshift(t.atomTypes[h]);else{if(2!==o)throw new Error(`Unexpected missing R-group: ${o}`);n.splice(1,0,t.atomTypes[h])}}return function(t,e,n){for(const[i,o]of n)t.atomTypes[i-1]=e[o-1]}(t,n,i),function(t,e){e.rNodes=Array.from(t.keys());for(let n=0;n<e.rNodes.length;n++)for(const i of[1,2])if(t.get(e.rNodes[n])===i){const t=e.rNodes[i-1];e.rNodes[i-1]=e.rNodes[n],e.rNodes[n]=t}}(i,o),y(e,o),o}(d,m,a,c),g=function(t){let e=[],n=t.indexOf("M  V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const i=t.indexOf(")",n);e=e.concat(t.substring(n,i).split(" ").slice(1).map((t=>parseInt(t)))),n=i,n=t.indexOf("M  V30 MDLV30/STEABS ATOMS=(",n)}return e}(h),v={atoms:d,bonds:m,meta:f,stereoAtoms:g};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,o=t.atoms.y;T(t,-i[e],-o[e]);const r=A(i[n],o[n]);S(t.atoms,-r),i[t.meta.rNodes[1]-1]<0&&x(t);const s=function(t){const e=function(t){const e=new Map;for(const n of t.bonds.atomPairs)for(let t=0;t<2;t++){const i=n[t],o=n[(t+1)%2];e.has(i)?e.get(i)?.push(o):e.set(i,new Array(1).fill(o))}return e}(t);let n=0;const i=t.atoms.atomTypes.length;let o=0;if(t.meta.terminalNodes.length<2)return null;for(;0===n;){const r=e.get(t.meta.terminalNodes[1])[o];if(t.atoms.atomTypes[r-1]===p.u.OXYGEN&&r!==t.meta.rNodes[1]&&(n=r),o++,o>i)return null}return n}(t);null!=s&&(function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){E(t,!0)}(t),S(t.atoms,-function(t,e){return A(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,s),function(t,e){const n=t.atoms.x;n[t.meta.rNodes[1]-1]>n[e-1]&&function(t,e,n){const i=e-1,o=n-1,r=t.atoms.x,s=t.atoms.y,a=r[i],l=s[i];r[i]=r[o],s[i]=s[o],r[o]=a,s[o]=l}(t,e,t.meta.rNodes[1])}(t,s))}(v):t===p.u.RIBOSE.symbol||t===p.u.DEOXYRIBOSE.symbol?function(t,e){const n=t.atoms.x,i=t.atoms.y;let o=t.meta.terminalNodes[0]-1;const r=t.meta.rNodes[1]-1;T(t,-n[o],-i[o]);const s=A(n[t.meta.rNodes[2]-1],i[t.meta.rNodes[2]-1]);S(t.atoms,-s),n[t.meta.rNodes[0]-1]>n[t.meta.rNodes[1]-1]&&x(t);const a=A(n[r],i[r]);S(t.atoms,3*Math.PI/2-a),e.value=function(t){const e=t.atoms.x,n=t.atoms.y,i=t.meta.rNodes[2]-1,o=t.meta.terminalNodes[2]-1,r=e[i]-e[o],s=n[i]-n[o];return Math.atan2(r,s)}(t),o=t.meta.terminalNodes[0]-1,T(t,-n[o],-i[o])}(v,o):t===p.u.PHOSPHATE.symbol?function(t){const e=t.meta.rNodes[1]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,o=t.atoms.y;T(t,-i[e],-o[e]);const r=A(i[n],o[n]);S(t.atoms,Math.PI/2-r)}(v):function(t,e){const n=t.atoms.x,i=t.atoms.y,o=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;T(t,-n[o],-i[o]);const s=A(n[r],i[r]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");S(t.atoms,Math.PI-s+a);const c=function(t,e){return(0,l.YN)(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:n[t.meta.rNodes[0]-1],y:i[t.meta.rNodes[0]-1]},{x:n[t.meta.terminalNodes[0]-1],y:i[t.meta.terminalNodes[0]-1]});if(1!=c)for(let t=0;t<n.length;++t)n[t]=(0,l.YN)(n[t]/c),i[t]=(0,l.YN)(i[t]/c)}(v,o),function(t,e,n){if("PEPTIDE"===t){b(e,t);const n=w(e,e.meta.rNodes[1]);n?.removedAtom&&(e.terminalR2Atom=n.removedAtom)}else n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(w(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],y(e.bonds,e.meta),b(e,t),w(e,e.meta.rNodes[1]),w(e,e.meta.rNodes[0]),w(e,e.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],T(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),b(e,t),w(e,e.meta.rNodes[1]))}(i,v,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===p.u.HYDROGEN&&(w(t,e+1),--e),++e}(v),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)"oh"===t.atoms.atomTypes[e]?.toLowerCase()&&(t.atoms.atomTypes[e]="O"),"?"===t.atoms.atomTypes[e]&&(t.atoms.atomTypes[e]="H"),++e}(v),function(t){const e=" RGROUPS=(1 1)";for(let n=0;n<(t.atoms.kwargs?.length??0);n++){const i=t.atoms.kwargs[n];i&&i.includes(e)&&(t.atoms.kwargs[n]=i.replace(e,""))}}(v),v}var r;return null}(e,n,i,o,r);if(!a)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);(0,h.LQ)(t,s,a)}}function y(t,e){const n=e.rNodes;e.terminalNodes=new Array(n.length).fill(0);const i=e.terminalNodes,o=t.atomPairs;let r=0,s=0;for(;r<o.length&&s<i.length;){for(let t=0;t<i.length;++t)for(let e=0;e<2;++e)o[r][e]===n[t]&&(i[t]=o[r][(e+1)%2],n.length,++s);++r}}function b(t,e){t.meta.rNodes.length>1&&(t.meta.backboneShift=v(t,t.meta.rNodes[1]-1,t.meta.terminalNodes[0]-1)),"RNA"===e&&t.meta.rNodes.length>2&&(t.meta.branchShift=v(t,t.meta.rNodes[2]-1,t.meta.terminalNodes[0]-1))}function v(t,e,n){return[(0,l.YN)(t.atoms.x[e]-t.atoms.x[n]),(0,l.YN)(t.atoms.y[e]-t.atoms.y[n])]}function w(t,e){if(void 0!==e){const n=e-1,i=t.atoms,o=t.bonds,r=t.meta,s=i.atomTypes.splice(n,1)[0];i.x=C(Float32Array,i.x,n,1),i.y=C(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let t=0;t<r.terminalNodes.length;++t)r.terminalNodes[t]>e?--r.terminalNodes[t]:r.terminalNodes[t]===e&&(r.terminalNodes[t]=-1);for(let t=0;t<r.rNodes.length;++t)r.rNodes[t]>e?--r.rNodes[t]:r.rNodes[t]===e&&(r.rNodes[t]=-1);let a=0;for(;a<o.atomPairs.length;){const t=o.atomPairs[a][0],n=o.atomPairs[a][1];t===e||n===e?(o.atomPairs.splice(a,1),o.bondTypes=C(Uint32Array,o.bondTypes,a,1),o.bondConfiguration.has(a)&&o.bondConfiguration.delete(a),o.kwargs.has(a)&&o.kwargs.delete(a),--a):(o.atomPairs[a][0]=t>e?t-1:t,o.atomPairs[a][1]=n>e?n-1:n),++a}let l=Array.from(o.bondConfiguration.keys());return l.forEach((t=>{if(o.bondConfiguration.has(t)&&t>n){const e=o.bondConfiguration.get(t);o.bondConfiguration.delete(t),o.bondConfiguration.set(t-1,e)}})),l=Array.from(o.kwargs.keys()),l.forEach((t=>{if(o.kwargs.has(t)&&t>n){const e=o.kwargs.get(t);o.kwargs.delete(t),o.kwargs.set(t-1,e)}})),s?{removedAtom:s}:void 0}}function C(t,e,n,i){const o=new t(e.length-i);let r=0,s=0;for(;r<e.length;)r===n&&(r+=i),o[s]=e[r],++s,++r;return o}function A(t,e){let n;if(0===t)n=e>0?0:Math.PI;else if(0===e)n=t>0?-Math.PI/2:Math.PI/2;else{const i=e/t,o=Math.atan(i);n=t<0?Math.PI/2+o:-Math.PI/2+o}return n}function S(t,e){if(0!==e){const n=t.x,i=t.y,o=Math.cos(e),r=Math.sin(e);for(let t=0;t<n.length;++t){const e=n[t];n[t]=(0,l.YN)(e*o-i[t]*r),i[t]=(0,l.YN)(e*r+i[t]*o)}}}function x(t){E(t,!1)}function E(t,e){if(e){const e=t.atoms.y;for(let t=0;t<e.length;t++)e[t]=-e[t]}else{const e=t.atoms.x;for(let t=0;t<e.length;t++)e[t]=-e[t]}const n=t.bonds.bondConfiguration;for(const[t,e]of n){const i=1===e?3:1;n.set(t,i)}}function T(t,e,n){const i=t.atoms.x,o=t.atoms.y;for(let t=0;t<i.length;++t)i[t]=(0,l.YN)(i[t]+e),void 0!==n&&(o[t]=(0,l.YN)(o[t]+n))}},294:(t,e,n)=>{"use strict";function i(t,e){return t[e.polymerType]?.[e.symbol]}function o(t,e){return!!t[e.polymerType]?.[e.symbol]}function r(t,e,n){let i=t[e.polymerType];i||(i=t[e.polymerType]={}),i[e.symbol]=n}n.d(e,{Cg:()=>s,LQ:()=>r,bq:()=>o,vF:()=>a,xb:()=>i});class s extends Map{constructor(t){super(t)}}class a{constructor(t,e){this.molfile=t,this.monomers=e}static createEmpty(){return new a("",new s(null))}}},330:(t,e,n)=>{"use strict";n.d(e,{kA:()=>o,pz:()=>s,qj:()=>r,vG:()=>a});var i=n(2003);function o(t,e){return t?t.columns.getUnusedName(e):e}function r(t,e){return o(t,`molfile(${e})`)}function s(t){let e;if(t===i.YI.PT||t===i.YI.UN)e="PEPTIDE";else{if(t!==i.YI.RNA&&t!==i.YI.DNA)throw new Error(`Unexpected alphabet '${t}'.`);e="RNA"}return e}function a(t){const e=7===t.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t);return e?[parseInt(e[1],16)/256,parseInt(e[2],16)/256,parseInt(e[3],16)/256,e.length>4?parseInt(e[4],16)/256:.3]:null}},1093:(t,e,n)=>{"use strict";n(7362);class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(t,e,n)=>{"use strict";n.d(e,{e:()=>i});class i{static makePalette(t,e=!1,n=i){const o={};return t.forEach((t=>{const n=t[0],i=t[1];n.forEach(((t,n)=>{o[t]=this.colourPalette[i][e?0:n]}))})),new n(o)}constructor(t){this._palette=t}get(t,e){return this._palette[t]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(t,e,n)=>{"use strict";n.d(e,{O:()=>r,n:()=>o});var i=n(1858);class o{constructor(t,e=!0,n){return this.substructure=t,this.readOnly=e,this.logger=n,new Proxy(this,{set:(t,e,n)=>{if(this.logger?.debug(`BioFilterProps.set ${e.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return t[e]=n,!0}})}}class r{constructor(){this.onChanged=new i.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(t){this._propsChanging=!0;try{this._props=t,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const t={};for(const[e,n]of Object.entries(this.props))"_onChanged"!==e&&"logger"!==e&&(t[e]=this.props[e]);return t}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(t,e,n)=>{"use strict";var i=n(6082),o=n(7362),r=n(6718);function s(t,e=!0){if(null==t)return"rgb(100,100,100)";const n=i.Color.fromHtml(t);if(e){const t=i.Color.g(n),e=i.Color.r(n),o=i.Color.b(n),r=Math.sqrt(Math.pow(0-e,2)+Math.pow(0-t,2)+Math.pow(0-o,2));if(r>210)return`rgb(${e/r*210},${t/r*210},${o/r*210})`}return i.Color.toRgb(n)}class a{static hashCode(t){let e=0;if(0===t.length)return e;for(let n=0;n<t.length;n++)e=(e<<5)-e+t.charCodeAt(n),e|=0;return e}}class l{}class c extends l{static get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,r.pj)().then((t=>{t.awaitLoaded(1/0).then((()=>{const e=t.getMonomerLib();e.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=e.getPolymerTypes();for(const t of this.polymerTypes){const n=e.getMonomerSymbolsByType(t);for(const i of n){const n=e.getMonomer(t,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][t]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(o.e.colourPalette))}get(t,e){const n=c.palette.length,i=c.customMonomerColors[t],o=e??"PEPTIDE";if(i&&i[o])return i[o];const r=a.hashCode(t)%n;return s(c.palette[r])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(t,e,n)=>{"use strict";n.d(e,{BG:()=>s,sD:()=>l});var i=n(4328),o=n(1858),r=n(8070);function s(t){let e=null,n=null;try{n=t.dart?t.gridColumn:null,e=n?n.temp:null}catch{[n,e]=[null,null]}const i=t.cell.column;if(e=e??(i?i.temp:null),!e)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,e]}class a{onKeyDown(t,e){}onKeyPress(t,e){}onMouseEnter(t,e){}onMouseLeave(t,e){}onMouseDown(t,e){}onMouseUp(t,e){}onMouseMove(t,e){}onClick(t,e){}onDoubleClick(t,e){}}class l extends a{constructor(t,e,n){super(),this.gridCol=t,this.tableCol=e,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++l.viewerCounter,this.errors=[],this._onRendered=new o.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((t=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(t){this.logger.error(t)}})))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((t=>{try{const e=t.args.dataFrame;this.tableCol?.dataFrame.id!==e.id||this.destroyed||this.destroy()}catch(t){this.logger.error(t)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((t=>{try{const e=t.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===e.id&&!this.destroyed&&this.destroy()}catch(t){this.logger.error(t)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const t of this.subs)t.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(t){this.invalidateGrid()}async awaitRendered(t=1e4,e=`${t} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,r.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),t,`${n}, ${e}`),this.errors.length>0){const t=this.errors[0];throw this.errors=[],t}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(t,e,n)=>{"use strict";n.d(e,{s:()=>i});const i={true:"1",false:"0"}},6882:(t,e,n)=>{"use strict";n.d(e,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553),g=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(t,e,n,i,r){if(super(t,e,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})));const t=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((e=>e.args.source===this.tableCol&&t.includes(e.args.key)))),200).subscribe((t=>{this.reset()}))),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((t=>t.args.source===this.tableCol&&t.args.key===l.gp.positionShift))),200).subscribe((t=>{this.reset()})))}}calculateFontBasedSpacing(t){const e=t.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const t=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof t||isNaN(t)||(n=Math.max(t,1))}return{lineHeight:Math.max(1.4*n,e.fontBoundingBoxAscent+e.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(t){return"true"===t.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(t,e,n,i,o,r){if(this.dirty)try{this.reset()}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n)}const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(t),l=e-2*this.padding;let c=0;const h=[];if(i.length>0)for(let e=o;e<i.length;e++){const n=i.getOriginal(e),o=this.props.monomerToShort(n,r);h.push({text:o,posIdx:e}),c=Math.max(c,t.measureText(o).width)}if(0===h.length)return{lineLayouts:[],lineHeight:s};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,f=Math.max(0,Math.floor(m/s)),g=[];let y=0;for(let t=0;t<f&&y<h.length;t++){const e=[];for(let t=0;t<p&&y<h.length;t++){const n=h[y],i=this.padding+t*(d+a);e.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}g.push({lineIdx:t,elements:e})}return{lineLayouts:g,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const t=await(0,h.pj)();this.sysMonomerLib=t.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(t){let e=12;return t&&t.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(e=Math.max(t.temp[".mm.cellRenderer.fontSize"],1)),{font:`${e}px monospace`,fontWidth:.6*e}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<e&&(this.colWidth=e,this.dirty=!0),this.dirty)try{this.reset()}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(t){const e=new Array(t.length+1);e[0]=this.padding;for(let n=1;n<e.length;n++)e[n]=e[n-1]+t[n-1];let n=e[0];for(let t=1;t<e.length;t++)e[t]?n=e[t]:e[t]=n;return e}getCellMonomerLengthsForSeqValue(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(e/i)+o,s=n.splitter(t),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let t=o;t<a;++t){const i=s.getOriginal(t),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[t-o]=a,c+=a,c>e)break}return l}getCellMonomerLengthsForSeq(t){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const e=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+e,r=n.getSplitted(t),s=Math.min(o,r.length);let a=this._monomerLengthList[t];if(null===a||a.length!=s-e){a=this._monomerLengthList[t]=new Array(r.length);let i=0;for(let t=e;t<s;++t){const o=r.getOriginal(t),s=this.props.monomerToShort(o,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[t-e]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var t;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const t=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return t&&t.dart?{startIdx:Math.max(Math.floor((t?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((t?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(t){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,s=Math.ceil(this.colWidth/o)+r;for(let t=n;t<i;t++){if(this._processedRows.get(t)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t,s),i=Math.min(s,n.length);i-r>e.length&&e.push(...new Array(i-r-e.length).fill(o));let a=0;for(let t=r;t<i;++t){const i=n.getOriginal(t),o=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(e[t-r]=Math.max(e[t-r]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(t,!0)}return e}getPosition(t,e,n,i){const[o,r]=this.getCellMonomerLengths(t,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t).length?null:function(t,e,n){if((n??0)>0&&e<(t[0]??0)+n)return-1;e-=n??0;let i,o=100,r=0,s=t.length-1;for(;r<=s;){if(i=Math.floor((s+r)/2),t[i]<=e&&e<t[i+1])return i;if(e<t[i]?s=i-1:r=i+1,--o<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(t)}. `)}return null}(r,e,i)}setMonomerLengthLimit(t){this.monomerLengthLimit!=t&&(this.monomerLengthLimit=t,this.dirty=!0)}setSeparatorWidth(t){this.separatorWidth!=t&&(this.props.separatorWidth=t,this.dirty=!0)}get positionShift(){const t=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(t)?0:Math.max(t,0)}render(t,e,n,i,r,a,c){const h=a.grid?.canvas===t.canvas;if(!this.seqHelper)return;const m=this.tableCol,f=this.positionShift;t.save();try{const c=this.seqHelper.getSeqHandler(m);let u=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const t=parseInt(m.getTag(d.gp.maxMonomerLength));u=!isNaN(t)&&t?t:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=u){let t=0;const e=8;t=m.temp[".mm.cellRenderer.gapLength"]??t,this.setMonomerLengthLimit(u),this.setSeparatorWidth(c.isMsa()?e:t),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false,this.dirty=!0}const g=a.cell.rowIndex,b=a.cell.value;h&&(i=v(a.grid,t,e,i,window.devicePixelRatio)),t.beginPath(),t.rect(e,n,i,r),t.clip(),t.font=this.props?.font??"12px monospace",t.textBaseline="top";const w=m.meta.units,C=m.getTag(l.gp.aligned),A=m.getTag(l.gp.separator)??"",S=h?c.getSplitted(g):c.splitter(b);let x=d.yg.classic;C?.includes("MSA")&&w===l.Hi.SEPARATOR&&(x=d.yg.MSA);const E=m.temp["reference-sequence"],T=this.tableCol.temp["current-word"],M=(()=>{const t=(0,c.splitter)(null!=E&&""!==E?E:T??"");return s().count(0).take(t.length).slice(f).map((e=>t.getCanonical(e))).toArray()})(),_=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)){const s=[],l=this.calculateMultiLineLayoutDynamic(t,i,r,S,f,u);let h=n+this.padding;1===l.lineLayouts.length&&(h=n+(r-l.lineHeight)/2);for(const i of l.lineLayouts){const r=h+i.lineIdx*l.lineHeight;for(const h of i.elements){const u=e+h.x,p=h,g=p.posIdx,b=S.getCanonical(g);let v=y;const w=this.getMonomerLib();w&&(v=w.getMonomerTextColor(c.defaultBiotype,b));let C=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&M.length>0){const t=g-f;t>=0&&t<M.length&&b===M[t]&&(C=.7)}s.push({lineIdx:i.lineIdx,monomerIdx:g-f,bounds:new o.Rect(h.x,r-n,h.width,l.lineHeight),sequencePosition:g}),(0,d.oZ)(t,p.om,u,r,h.width,l.lineHeight,{color:v,isMultiLineContext:!0,transparencyRate:C,selectedPosition:isNaN(_)||_<1?void 0:_,wordIdx:g})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,s)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(f)?t.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,i);h||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,i)));const s=this.props.separatorWidth+1*this.props.fontCharWidth,l=Math.min(S.length,Math.ceil(i/s)+f);for(let s=f;s<l;++s){const l=s<S.length?S.getOriginal(s):c.defaultGapOriginal,h=s<S.length?S.getCanonical(s):c.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(c.defaultBiotype,h));const m={color:p,pivot:0,left:!0,transparencyRate:0,separator:A,last:s===S.length-1,drawStyle:x,maxWord:o,wordIdx:s-f,gridCell:a,referenceSequence:M,maxLengthOfMonomer:u,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(_)||_<1?void 0:_-f};(0,d.oZ)(t,l,e+this.padding+this._leftThreeDotsPadding,n,i,r,m)}if(this.shouldRenderShiftedThreeDots(f)){const s={color:y,pivot:0,left:!0,transparencyRate:0,separator:A,last:!1,drawStyle:x,maxWord:o,wordIdx:0,gridCell:a,maxLengthOfMonomer:u,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,d.oZ)(t,"...",e+this.padding,n,i,r,s)}}}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n),this.errors.push(t)}finally{t.restore()}}shouldRenderShiftedThreeDots(t){return t>0&&(!this.gridCol||!this.gridCol.dart||!this.gridCol.grid||!this.gridCol.grid.dart||(this.gridCol.grid.props.colHeaderHeight??0)<=50)}onMouseMove(t,e){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==t.tableRowIndex)return;const o=this.positionShift,r=t.bounds,s=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=e.offsetY-r.y;this.gridCol?.grid?.canvas&&(this.gridCol.grid.canvas.style.cursor="default");let c=null;const h=this._cellBounds.get(t.tableRowIndex);if(h){for(const t of h)if(t.bounds.contains(s,a)){c=t.monomerIdx;break}}else{const e=this.shouldRenderShiftedThreeDots(o)&&(this._leftThreeDotsPadding??0)>0?this._leftThreeDotsPadding:0;c=this.getPosition(t.tableRowIndex,s,r.width,e)}this.logger.debug(`${n}, argsX: ${s}, argsY: ${a}, left: ${c}`);const u=this.seqHelper.getSeqHandler(this.tableCol),d=u.getSplitted(t.tableRowIndex);if(null!==c&&c>=0&&c+o<d.length){const n=u.alphabet??l.YI.UN,r={position:c,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:d.getCanonical(c+o)},s=[];let a=this._monomerStructureMap[r.symbol];if(!a){const t=this.getMonomerLib();a=this._monomerStructureMap[r.symbol]=t?t.getTooltip(r.biotype,r.symbol):i.divText("Monomer library is not available")}s.push(a),i.tooltip.show(i.divV(s),e.x+16,e.y+16),(0,f.WN)(t,r)}else-1===c?i.tooltip.show(i.divText(`${Math.min(o,d.length)} hidden monomers`),e.x+16,e.y+16):i.tooltip.hide(),(0,f.WN)(t,null)}}function v(t,e,n,i,o){return t?Math.max(Math.min(t.canvas.width/o-n,i)):Math.max(e.canvas.width/o-n,0)}},3856:(t,e,n)=>{"use strict";n.d(e,{Mn:()=>h,gp:()=>c,oZ:()=>p,yg:()=>u});var i=n(6082),o=n(7278);const r="rgb(100,100,100)",s="#808080",a="rgb(0,0,0)",l=o.zS;var c,h,u;!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(c||(c={})),function(t){t.applyToBackground=".m.cellRenderer.applyToBackground"}(h||(h={})),function(t){t.MSA="MSA",t.classic="classic"}(u||(u={}));const d=new class{constructor(){this.color=r,this.pivot=0,this.left=!1,this.transparencyRate=0,this.separator="",this.last=!1,this.drawStyle=u.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0,this.isMultiLineContext=!1,this.lineNumber=0}};function p(t,e,n,o,c,h,p){var m,f,g;const y={...d,...p};if(y.isMultiLineContext){t.textBaseline="middle",t.textAlign="center";let i=e;null!=y.maxLengthOfMonomer&&(i=l(i,y.maxLengthOfMonomer));const s=Math.max(.1,1-(y.transparencyRate??0));t.globalAlpha=s;const u=t.measureText(i),d=u.fontBoundingBoxAscent+u.fontBoundingBoxDescent,p=o+(h-d)/2+u.fontBoundingBoxAscent;let m=y.color??r;return m&&m!==r||(m=a),t.fillStyle=m,y.selectedPosition===y.wordIdx+1&&(t.save(),t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n,o,c,h),t.restore(),t.fillStyle=m),t.fillText(i,n+c/2,p),t.globalAlpha=1,t.textBaseline="top",t.textAlign="start",n+c}p.logger?.debug("Bio: printLeftOrCentered(), start"),t.textAlign="start";let b=e.substring(0),v=y.last?"":y.separator;y.drawStyle===u.MSA&&(v="");let w=!0,C=!0,A="difference";if(null!=y.gridCell&&null!=y.gridCell.cell.column&&(w=y.gridCell.cell.column.temp["color-code"]??!0,C=y.gridCell.cell.column.temp["compare-with-current"]??!0,A=y.gridCell.cell.column.temp["highlight-difference"]??"difference"),y.referenceSequence){const t=y.referenceSequence[y.wordIdx];C&&y.referenceSequence.length>0&&"difference"===A&&(y.transparencyRate=b==t?.7:y.transparencyRate),C&&y.referenceSequence.length>0&&"equal"===A&&(y.transparencyRate=b!=t?.7:y.transparencyRate)}null!=y.maxLengthOfMonomer&&(b=l(b,y.maxLengthOfMonomer));const S=b+v;(m=y.monomerTextSizeMap)[S]??(m[S]=t.measureText(S));let x=y.monomerTextSizeMap[S];(f=y.monomerTextSizeMap)[b]??(f[b]=t.measureText(b));let E=y.monomerTextSizeMap[b].width;const T=h/2-(x.fontBoundingBoxAscent+x.fontBoundingBoxDescent)/2+1;(g=y.monomerTextSizeMap)[v]??(g[v]=t.measureText(v));const M=y.monomerTextSizeMap[v].width;function _(e,r){let l=w?y.color:a;y.selectedPosition===y.wordIdx+1&&(t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n+e-4,o-5,y.monomerTextSizeMap[b].width+8,h+10),l=i.Color.toHtml(i.Color.setAlpha(i.Color.fromHtml(l),255))),t.fillStyle=l,t.globalAlpha=1-y.transparencyRate,y.drawStyle===u.classic&&(t.fillText(b,n+e,o+T),t.fillStyle=s,t.fillText(v,n+r,o+T)),y.drawStyle===u.MSA&&t.fillText(b,n+e,o+T),t.globalAlpha=1}x=x.width,y.drawStyle===u.MSA&&(E=y.maxWord[y.wordIdx],x=y.maxWord[y.wordIdx]);const I=(y.maxWord[y.wordIdx]??0)-(y.maxWord[0]??0);if(y.left||x>c)return _(I,I+E),n+I+E+M;{const t=(c-x)/2;return _(t,t+E),n+I+t+E}}},6307:(t,e,n)=>{"use strict";n.d(e,{F:()=>s});var i=n(7389),o=n(6082),r=n(439);function s(t,e,n){let s=0,a=null;for(const e of Object.values(t))s+=e,a=null===a?e:Math.max(a,e);const l=a/s,c=Object.assign({},...Array.from(Object.entries(t)).sort(((t,e)=>e[1]-t[1])).map((([t,a])=>{const c=a/s;let h;try{const i=n.getMonomerColors(e,t);h=i?.backgroundcolor||"#CCCCCC"}catch(e){console.warn(`Failed to get colors for monomer ${t}:`,e),h="#CCCCCC"}const u=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});u.style.width=50*c/l+"px",u.style.backgroundColor=h,r._S===t&&(u.style.borderWidth="1px",u.style.borderStyle="solid",u.style.borderColor=o.Color.toHtml(o.Color.lightGray));const d=r._S===t?"-":t,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([u,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),h=i.tableFromMap(c);return Array.from(h.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),h}},3151:(t,e,n)=>{"use strict";n.d(e,{EK:()=>l,Ec:()=>r,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>o});const i=["symbol","molfile","rgroups","name"],o="MonomerName",r={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(t,e,n)=>{"use strict";function i(t){return"string"==typeof t||t instanceof String?t:"StateError"===t.constructor.name?t.message:"StateError"===t.constructor.name&&"$thrownJsError"in t?i(t.$thrownJsError):t instanceof Error?t.message:t.toString()}function o(t){return t instanceof Error?t.stack:"StateError"===t.constructor.name&&"$thrownJsError"in t?o(t.$thrownJsError):void 0}function r(t){return[i(t),o(t)]}n.d(e,{AP:()=>r})},3516:(t,e,n)=>{"use strict";n.d(e,{m:()=>r});var i=n(6082),o=n(439);class r{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.meta.units=o.Hi.FASTA,[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},6873:(t,e,n)=>{"use strict";n.d(e,{Hx:()=>h,dW:()=>c});var i=n(6082),o=n(1991),r=n.n(o),s=n(2003),a=n(7278),l=n(439);function c(t=10**5){const e="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(t/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(e));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const o=[];return o.push(n),o.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),o}function h(t,e=s.Hi.SEPARATOR,n=s.YI.PT,o=(e===s.Hi.SEPARATOR?"-":void 0),c=void 0,h="seq",u=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,f=i.Column.fromType(i.COLUMN_TYPE.STRING,h,u);f.semType=i.SEMTYPE.MACROMOLECULE,f.meta.units=e,f.setTag(s.gp.alphabet,n),e==s.Hi.SEPARATOR&&f.setTag(s.gp.separator,o);const g=t.getSeqHandler(f);for(let t=0;t<u;t++){const n=r().count(0).take(d).map((t=>p[Math.floor(Math.random()*m)])).toArray(),i=g.joiner(new a.Mu(n,l.b9[e]));f.set(t,i)}return f}},439:(t,e,n)=>{"use strict";n.d(e,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>o,_S:()=>u,b9:()=>d,gp:()=>r,ot:()=>p,q7:()=>h,z1:()=>a});var i,o,r,s=n(2738);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm",t.CUSTOM="custom"}(i||(i={})),function(t){t.DNA="DNA",t.RNA="RNA",t.PT="PT",t.UN="UN"}(o||(o={})),function(t){t.aligned="aligned",t.alphabet="alphabet",t.alphabetSize=".alphabetSize",t.alphabetIsMultichar=".alphabetIsMultichar",t.separator="separator",t.isHelmCompatible=".isHelmCompatible",t.positionNames=".positionNames",t.positionLabels=".positionLabels",t.regions=".regions",t.positionShift=".positionShift",t.selectedPosition=".selectedPosition"}(r||(r={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},h=[new s.a(o.PT,c.fasta.peptide,.5),new s.a(o.DNA,c.fasta.dna,.55),new s.a(o.RNA,c.fasta.rna,.55)],u="",d={[i.FASTA]:"-",[i.SEPARATOR]:"",[i.HELM]:"*"},p=" , "},2003:(t,e,n)=>{"use strict";n.d(e,{Hi:()=>i.Hi,J9:()=>o.J9,Qf:()=>o.Qf,YI:()=>i.YI,dh:()=>o.dh,gp:()=>i.gp,mn:()=>o.mn,q7:()=>i.q7,qp:()=>o.qp,z1:()=>i.z1,zS:()=>o.zS});var i=n(439),o=n(7278)},2738:(t,e,n)=>{"use strict";n.d(e,{X:()=>o,a:()=>i});class i{constructor(t,e,n){this.name=t,this.alphabet=e,this.cutoff=n}}class o extends i{constructor(t,e,n){super(t.name,t.alphabet,t.cutoff),this.freq=e,this.similarity=n}}},7278:(t,e,n)=>{"use strict";n.d(e,{Iv:()=>y,J9:()=>p,Mu:()=>u,Qf:()=>w,dh:()=>f,mn:()=>S,p0:()=>A,pc:()=>C,qp:()=>g,tm:()=>m,zS:()=>v});var i=n(6082),o=n(1991),r=n.n(o),s=n(3527),a=n(3629),l=n(2738),c=n(439),h=(n(8924),n(1093),n(4152),n(8438));class u{get length(){return this.mList.length}isGap(t){return this.getOriginal(t)===this.gapOriginalMonomer}getCanonical(t){if(this.length<=t)throw new Error("Index out of bounds");const e=this.mList[t];return e!==this.gapOriginalMonomer?e:c._S}getOriginal(t){if(this.length<=t)throw new Error("Index out of bounds");return this.mList[t]}getCanonicalRegion(t,e){const n=Math.min(Math.max(0,t),this.length),i=Math.max(Math.min(this.length,e),0)-n,o=this.gapOriginalMonomer;return new Array(i).fill(null).map(((t,e)=>{const i=this.mList[e+n];return i===o?c._S:i}))}getOriginalRegion(t,e){const n=Math.min(Math.max(0,t),this.length),i=Math.max(Math.min(this.length,e),0);return new Array(i-n).fill(null).map(((t,e)=>this.mList[e+n]))}get gapOriginal(){return this.gapOriginalMonomer}constructor(t,e){this.mList=t,this.gapOriginalMonomer=e}}class d{get length(){return this.seqS.length}isGap(t){return this.getOriginal(t)===c.b9[c.Hi.FASTA]}getCanonical(t){if(this.length<=t)throw new Error("Index out of bounds");return this.isGap(t)?c._S:this.seqS[t]}getOriginal(t){if(this.length<=t)throw new Error("Index out of bounds");return this.seqS[t]}getCanonicalRegion(t,e){const n=Math.max(0,t),i=Math.min(this.length,e)-n,o=c.b9[c.Hi.FASTA];return new Array(i).fill(null).map(((t,e)=>{const i=this.seqS[e+n];return i===o?c._S:i}))}getOriginalRegion(t,e){const n=Math.max(0,t),i=Math.min(this.length,e);return this.seqS.slice(n,i)}get gapOriginal(){return c.b9[c.Hi.FASTA]}constructor(t){this.seqS=t}}const p=t=>{const e=r()(t.toString().matchAll(c.B5)).map((t=>t[2]??t[1])).toArray();return new u(e,c.b9[c.Hi.FASTA])},m=t=>t?new d(t):new u([],c.b9[c.Hi.FASTA]);function f(t,e=void 0){return n=>{if(n){let i;const o=new RegExp(`(?<=^|\\${t})("-"|'-'|[^\\${t}]*)(?=\\${t}|$)`,"g");return void 0!==e?(o.lastIndex=0,i=r()(n.matchAll(o)).take(e).map((t=>t[0])).toArray()):i=n.replaceAll('"-"',"").replaceAll("'-'","").split(t,e),new u(i,c.b9[c.Hi.SEPARATOR])}return new u([],c.b9[c.Hi.SEPARATOR])}}const g=t=>{const e=t.split("$")[0].split("|"),n=r()(e.map((t=>(t.match(/(?<=\{).+(?=})/)?.[0]?.split(".")??[]).map((t=>(0,h.D)(t)))))).flatten().toArray();return new u(n,c.b9[c.Hi.HELM])};function y(t,e,n=void 0){if(t.toLowerCase().startsWith(c.Hi.FASTA))return p;if(t.toLowerCase().startsWith(c.Hi.SEPARATOR))return f(e,n);if(t.toLowerCase().startsWith(c.Hi.HELM))return g;throw new Error(`Unexpected units ${t} .`)}const b=/([^\W_]+)/g;function v(t,e){if(t.length<=e)return t;const n=t.match(b),i=t.length>e||(n?.length??0)>1,o=n?.[0]??" ";return i?o.substring(0,e-1)+"…":o}function w(t){switch(t){case c.YI.DNA:return c.Vl.fasta.dna;case c.YI.RNA:return c.Vl.fasta.rna;case c.YI.PT:return c.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${t}'.`)}}function C(t,e,n="-"){const i=e.map((e=>{const i=function(t,e,n="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(n);const o=[],r=[];for(const n of i)o.push(n in t?t[n]:0),r.push(e.has(n)?1:0);const l=new s.Mi(o),c=new s.Mi(r);return(0,a.KE)(l,c)/((0,a.wQ)(l)*(0,a.wQ)(c))}(t,e.alphabet,n);return new l.X(e,t,i)}));let o;const r=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return o=r>0?i.find((t=>t.similarity===r)).name:c.YI.UN,o}function A(t,e,n="-"){const i=Object.keys(t),o=/\(|\)/;return C(i.filter((t=>3===t.split(o).filter((t=>!!t)).length)).length>.8*i.length?Object.entries(t).reduce(((t,[e,n])=>{const i=e.split(o)[1];return i&&(t[i]=n),t}),{}):t,e,n)}function S(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let n=e.find((t=>{const e=t.meta.units;return!!e&&-1!==e.indexOf("MSA")}))??null;return!n&&e.length>0&&(n=e[0]),n}},8312:(t,e,n)=>{"use strict";n.d(e,{Q:()=>o});var i=n(6082);async function o(){const t=i.Func.find({package:"Bio",name:"getSeqHelper"});if(0===t.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await t[0].prepare().call()).getOutputParamValue()}},3077:(t,e,n)=>{"use strict";n.d(e,{R:()=>o});var i=n(6082);function o(t,e){const n=t=>{const e=s.columns.addNewString((t+1).toString());return o.push(e),e},o=[],r=t.length,s=i.DataFrame.create(r),a=e.getSeqHandler(t);for(let t=0;t<r;++t){const e=a.getSplitted(t);for(let i=0;i<e.length;++i){const r=e.getCanonical(i);((o[i]??null)||n(i)).set(t,r,!1)}}return s}},7602:(t,e,n)=>{"use strict";n.d(e,{g:()=>r});var i,o=n(9192);!function(t){t[t.error=0]="error",t[t.warning=1]="warning",t[t.info=2]="info",t[t.debug=3]="debug"}(i||(i={}));class r{constructor(t){this.logger=t,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(t,e){const n=++this.syncCounter;this.logger.debug(`${t}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${t}, SYNC syncId = ${n}, START `),await e(),this.logger.debug(`${t}, SYNC syncId = ${n}, END `)})).catch((e=>{const[i,r]=(0,o.AP)(e);this.logger.error(`${t}, SYNC syncId = ${n}, ERROR:\n${i}`,void 0,r),this.errors.push(e)}))}resetErrors(){const t=this.errors;return this.errors=[],t}}},4326:(t,e,n)=>{"use strict";n.d(e,{Fo:()=>h,Lp:()=>r,P4:()=>s,fH:()=>o,gp:()=>i,lT:()=>l,mH:()=>a});var i,o,r,s,a,l,c=n(6082);!function(t){t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(o||(o={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(r||(r={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(s||(s={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=o.Entropy,this.positionWidth=20,this.verticalAlignment=r.MIDDLE,this.horizontalAlignment=s.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=25,this.maxHeight=300,this.maxMonomerLetters=5,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},6869:(t,e,n)=>{"use strict";var i;n.d(e,{o:()=>i}),function(t){t.BASE="HELM_BASE",t.SUGAR="HELM_SUGAR",t.LINKER="HELM_LINKER",t.AA="HELM_AA",t.CHEM="HELM_CHEM",t.BLOB="HELM_BLOB",t.NUCLEOTIDE="HELM_NUCLETIDE"}(i||(i={}))},5540:(t,e,n)=>{"use strict";t=n.hmd(t);var i,o=(i="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(t={}){var e,n,o=void 0!==t?t:{};o.ready=new Promise((function(t,i){e=t,n=i}));var r,s=Object.assign({},o),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),i&&(c=i),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(r=t=>{var e=new XMLHttpRequest;return e.open("GET",t,!1),e.responseType="arraybuffer",e.send(null),new Uint8Array(e.response)})),o.print||console.log.bind(console);var h,u,d=o.printErr||console.warn.bind(console);Object.assign(o,s),s=null,o.arguments&&o.arguments,o.thisProgram&&o.thisProgram,o.quit&&o.quit,o.wasmBinary&&(h=o.wasmBinary),o.noExitRuntime,"object"!=typeof WebAssembly&&T("no native wasm support detected");var p,m,f,g=!1;function y(){var t=u.buffer;o.HEAP8=p=new Int8Array(t),o.HEAP16=new Int16Array(t),o.HEAP32=new Int32Array(t),o.HEAPU8=m=new Uint8Array(t),o.HEAPU16=new Uint16Array(t),o.HEAPU32=f=new Uint32Array(t),o.HEAPF32=new Float32Array(t),o.HEAPF64=new Float64Array(t)}var b,v,w=[],C=[],A=[],S=0,x=null,E=null;function T(t){o.onAbort&&o.onAbort(t),d(t="Aborted("+t+")"),g=!0,t+=". Build with -sASSERTIONS for more info.";var e=new WebAssembly.RuntimeError(t);throw n(e),e}function M(t){return t.startsWith("data:application/octet-stream;base64,")}function _(t){try{if(t==b&&h)return new Uint8Array(h);if(r)return r(t);throw"both async and sync fetching of the wasm failed"}catch(t){T(t)}}function I(t,e,n){return function(t){return h||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return _(t)})):fetch(t,{credentials:"same-origin"}).then((function(e){if(!e.ok)throw"failed to load wasm binary file at '"+t+"'";return e.arrayBuffer()})).catch((function(){return _(t)}))}(t).then((function(t){return WebAssembly.instantiate(t,e)})).then((function(t){return t})).then(n,(function(t){d("failed to asynchronously prepare wasm: "+t),T(t)}))}function L(t){for(;t.length>0;)t.shift()(o)}function N(t){this.excPtr=t,this.ptr=t-24,this.set_type=function(t){f[this.ptr+4>>2]=t},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(t){f[this.ptr+8>>2]=t},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(t){t=t?1:0,p[this.ptr+12|0]=t},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(t){t=t?1:0,p[this.ptr+13|0]=t},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(t,e){this.set_adjusted_ptr(0),this.set_type(t),this.set_destructor(e)},this.set_adjusted_ptr=function(t){f[this.ptr+16>>2]=t},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(B(this.get_type()))return f[this.excPtr>>2];var t=this.get_adjusted_ptr();return 0!==t?t:this.excPtr}}function P(t){var e=u.buffer;try{return u.grow(t-e.byteLength+65535>>>16),y(),1}catch(t){}}function $(t){return o["_"+t]}M(b="wasmDbscan.wasm")||(v=b,b=o.locateFile?o.locateFile(v,c):c+v);var R="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function k(t,e,n,i,o){var r={string:t=>{var e=0;return null!=t&&0!==t&&(e=function(t){var e=function(t){for(var e=0,n=0;n<t.length;++n){var i=t.charCodeAt(n);i<=127?e++:i<=2047?e+=2:i>=55296&&i<=57343?(e+=4,++n):e+=3}return e}(t)+1,n=D(e);return function(t,e,n){!function(t,e,n,i){if(!(i>0))return 0;for(var o=n+i-1,r=0;r<t.length;++r){var s=t.charCodeAt(r);if(s>=55296&&s<=57343&&(s=65536+((1023&s)<<10)|1023&t.charCodeAt(++r)),s<=127){if(n>=o)break;e[n++]=s}else if(s<=2047){if(n+1>=o)break;e[n++]=192|s>>6,e[n++]=128|63&s}else if(s<=65535){if(n+2>=o)break;e[n++]=224|s>>12,e[n++]=128|s>>6&63,e[n++]=128|63&s}else{if(n+3>=o)break;e[n++]=240|s>>18,e[n++]=128|s>>12&63,e[n++]=128|s>>6&63,e[n++]=128|63&s}}e[n]=0}(t,m,e,n)}(t,n,e),n}(t)),e},array:t=>{var e,n,i=D(t.length);return e=t,n=i,p.set(e,n),i}},s=$(t),a=[],l=0;if(i)for(var c=0;c<i.length;c++){var h=r[n[c]];h?(0===l&&(l=G()),a[c]=h(i[c])):a[c]=i[c]}var u=s.apply(null,a);return function(t){return 0!==l&&F(l),function(t){return"string"===e?(n=t)?function(t,e,n){for(var i=e+n,o=e;t[o]&&!(o>=i);)++o;if(o-e>16&&t.buffer&&R)return R.decode(t.subarray(e,o));for(var r="";e<o;){var s=t[e++];if(128&s){var a=63&t[e++];if(192!=(224&s)){var l=63&t[e++];if((s=224==(240&s)?(15&s)<<12|a<<6|l:(7&s)<<18|a<<12|l<<6|63&t[e++])<65536)r+=String.fromCharCode(s);else{var c=s-65536;r+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else r+=String.fromCharCode((31&s)<<6|a)}else r+=String.fromCharCode(s)}return r}(m,n,i):"":"boolean"===e?Boolean(t):t;var n,i}(t)}(u)}var O,H={__cxa_throw:function(t,e,n){throw new N(t).init(e,n),t},abort:function(){T("")},emscripten_memcpy_big:function(t,e,n){m.copyWithin(t,e,e+n)},emscripten_resize_heap:function(t){var e,n=m.length,i=2147483648;if((t>>>=0)>i)return!1;for(var o=1;o<=4;o*=2){var r=n*(1+.2/o);if(r=Math.min(r,t+100663296),P(Math.min(i,(e=Math.max(t,r))+(65536-e%65536)%65536)))return!0}return!1}},G=(function(){var t,e,i,r,s={env:H,wasi_snapshot_preview1:H};function a(t,e){var n,i=t.exports;return o.asm=i,u=o.asm.memory,y(),o.asm.__indirect_function_table,n=o.asm.__wasm_call_ctors,C.unshift(n),function(){if(S--,o.monitorRunDependencies&&o.monitorRunDependencies(S),0==S&&(null!==x&&(clearInterval(x),x=null),E)){var t=E;E=null,t()}}(),i}if(S++,o.monitorRunDependencies&&o.monitorRunDependencies(S),o.instantiateWasm)try{return o.instantiateWasm(s,a)}catch(t){d("Module.instantiateWasm callback failed with error: "+t),n(t)}(t=h,e=b,i=s,r=function(t){a(t.instance)},t||"function"!=typeof WebAssembly.instantiateStreaming||M(e)||"function"!=typeof fetch?I(e,i,r):fetch(e,{credentials:"same-origin"}).then((function(t){return WebAssembly.instantiateStreaming(t,i).then(r,(function(t){return d("wasm streaming compile failed: "+t),d("falling back to ArrayBuffer instantiation"),I(e,i,r)}))}))).catch(n)}(),o._dbscan=function(){return(o._dbscan=o.asm.dbscan).apply(null,arguments)},o._malloc=function(){return(o._malloc=o.asm.malloc).apply(null,arguments)},o._free=function(){return(o._free=o.asm.free).apply(null,arguments)},function(){return(G=o.asm.stackSave).apply(null,arguments)}),F=function(){return(F=o.asm.stackRestore).apply(null,arguments)},D=function(){return(D=o.asm.stackAlloc).apply(null,arguments)},B=function(){return(B=o.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function t(){O||(O=!0,o.calledRun=!0,g||(L(C),e(o),o.onRuntimeInitialized&&o.onRuntimeInitialized(),function(){if(o.postRun)for("function"==typeof o.postRun&&(o.postRun=[o.postRun]);o.postRun.length;)t=o.postRun.shift(),A.unshift(t);var t;L(A)}()))}S>0||(function(){if(o.preRun)for("function"==typeof o.preRun&&(o.preRun=[o.preRun]);o.preRun.length;)t=o.preRun.shift(),w.unshift(t);var t;L(w)}(),S>0||(o.setStatus?(o.setStatus("Running..."),setTimeout((function(){setTimeout((function(){o.setStatus("")}),1),t()}),1)):t()))}if(o.ccall=k,o.cwrap=function(t,e,n,i){var o=!n||n.every((t=>"number"===t||"boolean"===t));return"string"!==e&&o&&!i?$(t):function(){return k(t,e,n,arguments)}},E=function t(){O||V(),O||(E=t)},o.preInit)for("function"==typeof o.preInit&&(o.preInit=[o.preInit]);o.preInit.length>0;)o.preInit.pop()();return V(),t.ready});"object"==typeof exports?t.exports=o:"function"==typeof define&&n.amdO?define([],(function(){return o})):"object"==typeof exports&&(exports.exportCppDbscanLib=o)},6295:(t,e,n)=>{"use strict";n.d(e,{$1:()=>s,Hf:()=>h,Hr:()=>E,Ii:()=>g,Qj:()=>m,T6:()=>x,TK:()=>A,be:()=>f,gt:()=>v,ij:()=>w,jL:()=>c,lO:()=>p,lP:()=>b,rR:()=>y,tO:()=>a,v_:()=>l,w_:()=>u,yK:()=>C,zn:()=>d});var i=n(8774),o=n(8498),r=n(6863);function s(t,e){const n=t.trueCount()+e.trueCount();if(0==n)return 1;const i=t.andWithCountBits(e,!0);return i/(n-i)}function a(t,e){return 1-s(t,e)}function l(t,e){return S(s(new i.A(t,32*t.length),new i.A(e,32*e.length)))}function c(t,e){let n=0;for(let i=0;i<t.length;i++)n+=Math.pow(t[i]-e[i],2);return Math.sqrt(n)}function h(t,e){let n=0;for(let i=0;i<t.length;i++)n+=Math.abs(t[i]-e[i]);return n}function u(t,e){let n=0,i=0,o=0;for(let r=0;r<t.length;r++)n+=t[r]*e[r],i+=t[r]*t[r],o+=e[r]*e[r];return(1-n/(Math.sqrt(i)*Math.sqrt(o)))/2}function d(t,e){return 1-function(t,e){const n=t.trueCount()+e.trueCount();return 0==n?0:2*t.andWithCountBits(e,!0)/n}(t,e)}function p(t,e){return 1-function(t,e){const n=t.trueCount()*e.trueCount();return 0==n?0:t.andWithCountBits(e,!0)/Math.sqrt(n)}(t,e)}function m(t,e){return Math.sqrt(t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0))}function f(t,e){return t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0)}function g(t,e){return 1-function(t,e){const n=t.trueCount()+e.trueCount(),i=t.andWithCountBits(e,!0);return i/(2*n-3*i)}(t,e)}function y(t,e){return S(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:t.andWithCountBits(e,!0)*n/(2*i)}(t,e))}function b(t,e){return S(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:(t.andWithCountBits(e,!0)*n-i)/i}(t,e))}function v(t,e){return 1-function(t,e){const n=Math.min(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e)}function w(t,e){return S(function(t,e){const n=Math.max(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e))}function C(t,e){return S(function(t,e){return 0==t.length?0:t.andWithCountBits(e,!0)/t.length}(t,e))}function A(t,e){return S(function(t,e){const n=t.andWithCountBits(e,!0),i=t.countBits(!0)+e.countBits(!0),o=t.length,r=o-i+n;return n==o||r==o?1:n/i+r/(2*o-i)}(t,e))}function S(t){return t<=0?3402823e32:1/t-1}function x(t){if(t&&null!=t.range&&t.range>0){const e=t.range;return(t,n)=>Math.abs(t-n)/e}return(t,e)=>Math.abs(t-e)}function E(t){const e=function(t){const e=t?.mostCommon??new Set;return(t,n)=>{const i=t.length,o=n.length;let r=0,s=0,a=0;for(;s<i&&a<o;)t[s]===n[a]?(e?.has(t[s])||++r,++s,++a):t[s]<n[a]?++s:++a;return r}}(t);return(t,n)=>0===n.length||0===t.length?1e4:Math.min(t.length,n.length)/(e(t,n)+1e-4)}o.aT.Tanimoto,o.aT.Dice,o.aT.Asymmetric,o.aT.BraunBlanquet,o.aT.Cosine,o.aT.Kulczynski,o.aT.McConnaughey,o.aT.RogotGoldberg,o.aT.Russel,o.aT.Sokal,o.aT.Hamming,o.aT.Euclidean,o.aT.Tanimoto,o.aT.Dice,o.aT.Asymmetric,o.aT.BraunBlanquet,o.aT.Cosine,o.aT.Kulczynski,o.aT.McConnaughey,o.aT.RogotGoldberg,o.aT.Russel,o.aT.Sokal,o.aT.Hamming,o.aT.Euclidean,o.aT.Tanimoto,o.aT.Dice,o.aT.Cosine,o.aT.Tanimoto,o.aT.Asymmetric,o.aT.Cosine,o.aT.Sokal,r.Z.HAMMING,r.Z.LEVENSHTEIN,r.Z.MONOMER_CHEMICAL_DISTANCE,r.Z.NEEDLEMANN_WUNSCH},684:(t,e,n)=>{"use strict";n.d(e,{C0:()=>r,GP:()=>i,Gi:()=>a,YP:()=>c,_X:()=>s,n3:()=>o,vb:()=>l});const i="dim-red-preprocessing-function",o="supportedSemTypes",r="supportedTypes",s="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},6863:(t,e,n)=>{"use strict";function i(t={}){const e=function(){if(!t||!t.scoringMatrix||!t.alphabetIndexes)return(t,e)=>t===e?0:1;if(t.scoringMatrix.length!==Object.keys(t.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const e=t.alphabetIndexes,n=t.scoringMatrix,i=Math.min(...Object.keys(e).map((t=>t.charCodeAt(0))))+1,o=new Float32Array((n.length+i)*(n.length+i));return Object.entries(e).forEach((([t,i])=>{const r=n[i];Object.entries(e).forEach((([e,i])=>{o[t.charCodeAt(0)*n.length+e.charCodeAt(0)]=r[i]}))})),(t,e)=>1-o[t.charCodeAt(0)*n.length+e.charCodeAt(0)]}(),n=t?.threshold??0;return(t,i)=>{let o=0;const r=t.length,s=i.length,a=Math.ceil(Math.max(r,s)*(1-n));r!==s&&(o=Math.abs(r-s));let l=0;for(let n=0;n<Math.min(r,s);n++)if(t[n]!==i[n]&&(l+=e(t[n],i[n]),l>a))return 1;return l+=o,l/=Math.max(r,s),l}}n.d(e,{Z:()=>s,V:()=>a});var o=n(2787);const r={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(t){t.HAMMING="Hamming",t.LEVENSHTEIN="Levenshtein",t.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",t.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(t,e)=>(0,o.I)(t,e)/Math.max(t.length,e.length)},[s.NEEDLEMANN_WUNSCH]:function(t){const e=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:o,alphabetIndexes:s}={...r,...t};Object.entries(s).forEach((([t,n])=>e[t.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(t,r)=>{const s=new Array(t.length+1).fill(!1),l=new Array(t.length+1).fill(!1);let c=0,h=1;for(let e=1;e<t.length+1;e++)a[0][e]=-i-(e-1)*i,a[1][e]=0;a[0][0]=0;for(let u=1;u<r.length+1;u++){a[h][0]=-i-(u-1)*i;for(let d=1;d<t.length+1;d++){const p=a[c][d-1]+o[e[t.charCodeAt(d-1)]][e[r.charCodeAt(u-1)]],m=a[c][d]-(s[d]||1===u||u===r.length?i:n),f=a[h][d-1]-(l[d-1]||1===d||d===t.length?i:n);a[h][d]=Math.max(p,f,m),a[h][d]===p?(s[d]=!1,l[d]=!1):a[h][d]===f?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=h,h=(h+1)%2}const u=Math.min(t.length,r.length);return(u-a[c][t.length])/u}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},8060:(t,e,n)=>{"use strict";n.d(e,{S:()=>i});const i="dimensionality-reducer-terminate-event"},9039:(t,e,n)=>{"use strict";var i;n.d(e,{c:()=>i}),function(t){t.UMAP="UMAP",t.T_SNE="t-SNE"}(i||(i={}))},8498:(t,e,n)=>{"use strict";var i,o,r,s,a,l,c;n.d(e,{EG:()=>a,Pn:()=>o,RR:()=>l,Wn:()=>c,aT:()=>r,m6:()=>s,xL:()=>i}),function(t){t.Levenshtein="Levenshtein",t.JaroWinkler="Jaro-Winkler",t.Manhattan="Manhattan String",t.Onehot="One-Hot"}(i||(i={})),function(t){t.Euclidean="Euclidean",t.Manhattan="Manhattan",t.Cosine="Vector Cosine"}(o||(o={})),function(t){t.Tanimoto="Tanimoto",t.Dice="Dice",t.Asymmetric="Asymmetric",t.BraunBlanquet="Braun-Blanquet",t.Cosine="Cosine",t.Kulczynski="Kulczynski",t.McConnaughey="Mc-Connaughey",t.RogotGoldberg="Rogot-Goldberg",t.Russel="Russel",t.Sokal="Sokal",t.Hamming="Hamming",t.Euclidean="Euclidean BitArray"}(r||(r={})),function(t){t.TanimotoIntArray="TanimotoIntArray"}(s||(s={})),function(t){t.Vector="Vector",t.String="String",t.BitArray="BitArray",t.MacroMolecule="MacroMolecule",t.Number="Number",t.IntArray="IntArray",t.NumberArray="NumberArray"}(a||(a={})),function(t){t.Difference="Difference"}(l||(l={})),function(t){t.CommonItems="Common Items"}(c||(c={}))},2780:(t,e,n)=>{"use strict";n(8498),n(9336)},9336:(t,e,n)=>{"use strict";var i=n(2787),o=n(944),r=n(6295),s=n(6863),a=n(8498);const l={[a.Pn.Euclidean]:r.jL,[a.Pn.Manhattan]:r.Hf,[a.Pn.Cosine]:r.w_},c={[a.xL.Levenshtein]:i.I,[a.xL.JaroWinkler]:o.Vb,[a.xL.Manhattan]:function(t,e){if(t.length!==e.length)return 1;{let n=0;for(let i=1;i<t.length;i++)n+=t[i]==e[i]?0:1;return n/t.length}},[a.xL.Onehot]:function(t,e){return t===e?0:1}},h={[a.aT.Tanimoto]:r.tO,[a.aT.Dice]:r.zn,[a.aT.Asymmetric]:r.gt,[a.aT.BraunBlanquet]:r.ij,[a.aT.Cosine]:r.lO,[a.aT.Kulczynski]:r.rR,[a.aT.McConnaughey]:r.lP,[a.aT.RogotGoldberg]:r.TK,[a.aT.Russel]:r.yK,[a.aT.Sokal]:r.Ii,[a.aT.Hamming]:r.be,[a.aT.Euclidean]:r.Qj},u={[a.m6.TanimotoIntArray]:r.v_},d={[a.RR.Difference]:r.T6},p={[a.Wn.CommonItems]:r.Hr},m={[a.EG.Vector]:{[a.Pn.Euclidean]:l[a.Pn.Euclidean],[a.Pn.Manhattan]:l[a.Pn.Manhattan],[a.Pn.Cosine]:l[a.Pn.Cosine]},[a.EG.String]:{[a.xL.Levenshtein]:c[a.xL.Levenshtein],[a.xL.JaroWinkler]:c[a.xL.JaroWinkler],[a.xL.Manhattan]:c[a.xL.Manhattan],[a.xL.Onehot]:c[a.xL.Onehot]},[a.EG.BitArray]:{[a.aT.Tanimoto]:h[a.aT.Tanimoto],[a.aT.Dice]:h[a.aT.Dice],[a.aT.Asymmetric]:h[a.aT.Asymmetric],[a.aT.BraunBlanquet]:h[a.aT.BraunBlanquet],[a.aT.Cosine]:h[a.aT.Cosine],[a.aT.Kulczynski]:h[a.aT.Kulczynski],[a.aT.McConnaughey]:h[a.aT.McConnaughey],[a.aT.RogotGoldberg]:h[a.aT.RogotGoldberg],[a.aT.Russel]:h[a.aT.Russel],[a.aT.Sokal]:h[a.aT.Sokal]},[a.EG.MacroMolecule]:{[s.Z.HAMMING]:s.V[s.Z.HAMMING],[s.Z.LEVENSHTEIN]:s.V[s.Z.LEVENSHTEIN],[s.Z.NEEDLEMANN_WUNSCH]:s.V[s.Z.NEEDLEMANN_WUNSCH],[s.Z.MONOMER_CHEMICAL_DISTANCE]:s.V[s.Z.MONOMER_CHEMICAL_DISTANCE]},[a.EG.Number]:{[a.RR.Difference]:d[a.RR.Difference]},[a.EG.IntArray]:{[a.m6.TanimotoIntArray]:u[a.m6.TanimotoIntArray]},[a.EG.NumberArray]:{[a.Wn.CommonItems]:p[a.Wn.CommonItems]}};Object.keys(m).reduce(((t,e)=>{for(const n of Object.keys(m[e]))t[n]=e;return t}),{})},8774:(t,e,n)=>{"use strict";n.d(e,{A:()=>i});class i{constructor(t,e=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof t){const n=t,o=i._createBuffer(n);if(e)for(let t=0;t<o.length;t++)o[t]=-1;this._data=o,this._length=n}else{if(!(t instanceof Uint32Array))throw new Error("Invalid constructor");this._data=t,this._length=e}}getRawData(){return this._data}assureGoez(t,e){if(t<0)throw new Error(`${e} should be greater than zero`)}assureInRange(t,e,n,i){if(t<e||t>n)throw new Error(`Argument ${i} (${t}) out of range (${e}, ${n})`)}copy(t,e,n){for(let i=0;i<n;i++)e[i]=t[i]}copyFrom(t){if(this._length!=t._length)throw new Error(`Lengths differ (${this._length} != ${t._length})`);this.copy(t._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(t){this._data=t,this._version++}get version(){return this._version}set version(t){this._version=t}incrementVersion(t=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(t){this._versionedName=t,this._versionedNameVersion=this._version}get self(){return this}setLength(t){if(t<0)throw new Error("should be >= 0");if(t==this._length)return;const e=Math.floor((t+31)/32);if(e>this._data.length||e+this.SHRINK_THRESHOLD<this._data.length){const t=new Uint32Array(e);this.copy(this._data,t,e>this._data.length?this._data.length:e),this._data=t}t>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,e)),this._length=t,this._version++}static fromAnd(t,e){if(t._length!=e._length)throw new Error(`Lengths differ (${t._length} != ${e._length})`);const n=new i(t._length);n._length=t._length,n._data=i._createBuffer(n._length),n._version=0;const o=t.lengthInInts;for(let i=0;i<o;i++)n._data[i]=t._data[i]&e._data[i];return n}static _createBuffer(t){return new Uint32Array(Math.floor((t+31)/32))}static fromValues(t){const e=new i(t.length);e._version=0;for(let n=0;n<e._length;n++)t[n]&&(e._data[Math.floor(n/32)]|=1<<(n%32&31));return e}static fromSeq(t,e){const n=new i(t);for(let i=0;i<t;++i)n.setBit(i,e(i));return n._version=0,n}static fromString(t){return i.fromSeq(t.length,(e=>"1"==t.charAt(e)))}static fromUint32Array(t,e){const n=new i(t);return n._data=e,n}static fromBytes(t){const e=t.length,n=new i(8*e);n._data=new Uint32Array(Math.floor((e+3)/4)),n._length=8*e;let o=0,r=0;for(;e-r>=4;)n._data[o++]=255&t[r]|(255&t[r+1])<<8|(255&t[r+2])<<16|(255&t[r+3])<<24,r+=4;return e-r==3&&(n._data[o]=(255&t[r+2])<<16),e-r==2&&(n._data[o]|=(255&t[r+1])<<8),e-r==1&&(n._data[o]|=255&t[r]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(t){if(this==t)return!0;if(null==t)return!1;if(this._length!=t._length)return!1;if(0==this._length)return!0;for(let e=0;e<this._data.length-1;e++)if(this._data[e]!=t._data[e])return!1;for(let e=8*(this._data.length-1);e<this._length;e++)if(this.getBit(e)!=t.getBit(e))return!1;return!0}clone(){const t=new i(0,!1);return t._data=Uint32Array.from(this._data),t._length=this._length,t._version=this._version,t}init(t,e){this.setAll(!1,!1);for(let e=0;e<this._length;e++)t(e)&&(this._data[Math.floor(e/32)]|=1<<(e%32&31));return this.incrementVersion(e),this}invert(t=!0){for(let t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const n=t?-1:0,i=this.lengthInInts;for(let t=0;t<i;t++)this._data[t]=n;this.incrementVersion(e)}setIndexes(t,e=!0,n=!0,i=!0){n&&this.setAll(!e,!1);for(const n of t)this.setFast(n,e);this.incrementVersion(i)}everyIndex(t,e=!0){for(const n of t)if(this.getBit(n)!=e)return!1;return!0}anyIndex(t,e=!0){for(const n of t)if(this.getBit(n)==e)return!0;return!1}setWhere(t,e=!0,n=!0,i=!0,o=!0){if(n&&o&&this.setAll(!e,!1),o)for(let n=0;n<this._length;n++)t(n)&&this.setFast(n,e);else for(let n=0;n<this._length;n++)this.setFast(n,t(n)?e:!e);this.incrementVersion(i)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return i.fromValues(n)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return n}setRange(t,e,n,i=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const o=Math.min(t,e),r=Math.max(t,e);if(n)for(let t=o;t<=r;t++)this.setTrue(t);else for(let t=o;t<=r;t++)this.setFalse(t);return this.incrementVersion(i),this}setRandom(t,e,n=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let n=0;n<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),n++)}this.incrementVersion(n)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let e=0;e<n;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]|=t._data[e];return this.incrementVersion(e),this}xor(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]^=t._data[e];return this.incrementVersion(e),this}insertAt(t,e,n=!1){if(this.assureInRange(t,0,this._length,"pos"),0==e)return;const i=this._length;this.setLength(this._length+e);for(let n=i-1;n>=t;n--)this.setBit(n+e,this.getBit(n));for(let i=t;i<t+e;i++)this.setBit(i,n)}removeAt(t,e=1){if(e<0)throw new Error("n cannot be negative");if(this.assureInRange(t,0,this._length-e,"pos"),this.contains(!0))for(let n=t;n<this._length-e;n++)this.setBit(n,this.getBit(n+e));this.setLength(this._length-e)}removeByMask(t,e=!0){if(this._length!=t.length)throw new Error("length != mask.length");if(t==this)this.setLength(t.countBits(!e)),this.setAll(!e);else{let n=0;for(let i=-1;-1!=(i=t.findNext(i,!e));)this.setFast(n++,this.getBit(i));this._length=n,this._version++}return this}getBit(t){return!!(this._data[Math.floor(t/32)]&1<<(31&t))}setBit(t,e,n=!0){this.setFast(t,e),this._version++}setFast(t,e){e?this._data[Math.floor(t/32)]|=1<<(31&t):this._data[Math.floor(t/32)]&=~(1<<(31&t))}setTrue(t){this._data[Math.floor(t/32)]|=1<<(31&t)}setFalse(t){this._data[Math.floor(t/32)]&=~(1<<(31&t))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(t){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const t=this.lengthInInts;let e=0;for(;e<t-1;e++)for(let t=this._data[e];0!=t;t>>>=8)this._selectedCount+=i._onBitCount[255&t];let n=this._data[e];const o=31&this._length;for(0!=o&&(n&=~(4294967295<<o));0!=n;n>>>=8)this._selectedCount+=i._onBitCount[255&n];this._selectedCountVersion=this._version}return t?this._selectedCount:this._length-this._selectedCount}countWhere(t){let e=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)e+=t(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)e+=t(n)?1:0;return e}andWithCountBits(t,e){if(0==this._length)return 0;let n=0;const o=this.lengthInInts;let r=0;for(;r<o-1;r++)for(let e=this._data[r]&t._data[r];0!=e;e>>>=8)n+=i._onBitCount[255&e];let s=this._data[r]&t._data[r];const a=31&this._length;for(0!=a&&(s&=~(4294967295<<a));0!=s;s>>>=8)n+=i._onBitCount[255&s];return e?n:this._length-n}clear(){this.setLength(0)}contains(t){return this.findNext(-1,t)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(t,e=!0){if(this.assureInRange(t,-1,this._length,"index"),t>=this._length-1)return-1;let n=31&(t=t<0?0:t+1);const o=this.lengthInInts;for(let r=Math.floor(t/32);r<o;r++){let o=e?this._data[r]:~this._data[r];if(0!=n)o&=4294967295<<n&4294967295,n=0;else if(!e&&-4294967296==o)continue;for(let e=0;0!=o;e+=8,o>>>=8){const n=i._firstOnBit[255&o];if(n>=0)return(t=n+32*r+e)>=this._length?-1:t}}return-1}findPrev(t,e=!0){if(0==t)return-1;this.assureInRange(t,-1,this._length,"index");let n=1+(t=t<0?this._length-1:t-1)&31;for(let o=Math.floor(t/32);o>=0;o--){let t=e?this._data[o]:~this._data[o];0!=n&&(t&=~(4294967295<<n),n=0);for(let e=24;0!=t;e-=8,t<<=8){const n=i._lastOnBit[t>>>24];if(n>=0)return n+32*o+e}}return-1}}i._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),i._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),i._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(t,e,n)=>{"use strict";n.d(e,{cb:()=>a,PE:()=>s}),n(4328);var i=n(6082);n(9982),i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var o,r=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function s(t,e,n,i=0,o="timeout"){return r(this,void 0,void 0,(function*(){return new Promise(((r,s)=>{const a=t.subscribe((t=>{try{e(t),r("OK")}catch(t){s(t)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),s(o)}),i);n()}))}))}function a(t){return r(this,void 0,void 0,(function*(){yield new Promise((e=>setTimeout(e,t)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(o||(o={})),i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])])},3527:(t,e,n)=>{"use strict";n.d(e,{Mi:()=>i});class i extends Float32Array{}},3629:(t,e,n)=>{"use strict";n.d(e,{KE:()=>a,S8:()=>l,dC:()=>r,vA:()=>o,wQ:()=>s});var i=n(3527);function o(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function r(t,e,n=1){const r=t.length;o(r==e.length,"Vector lengths do not match.");const s=new i.Mi(r);for(let i=0;i<t.length;++i)s[i]=t[i]+n*e[i];return s}function s(t){let e=0;for(let n=0;n<t.length;n++)e+=t[n]*t[n];return Math.sqrt(e)}function a(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<t.length;i++)n+=t[i]*e[i];return n}function l(t){const e=t.length;let n=0,i=0;for(let o=0;o<e;++o)n+=t[o],i+=Math.pow(t[o],2);const o=n/e,r=1/Math.sqrt(i/e-Math.pow(o,2));for(let n=0;n<e;++n)t[n]=(t[n]-o)*r;return t}},1913:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3282),o=n(9029),r=n(1520),s=n(2586),a=n(8708),l=n(2023),c="errorMessage",h=new i.Name("emUsed"),u={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(t,e={})=>{if(!t.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(t.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return t.addKeyword(function(t){return{keyword:c,schemaType:["string","object"],post:!0,code(e){const{gen:n,data:f,schema:g,schemaValue:y,it:b}=e;if(!1===b.createErrors)return;const v=g,w=o.strConcat(l.default.instancePath,b.errorPath);function C(t,e){return o.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,i._`${t}.instancePath === ${w}`,i._`${t}.keyword in ${e}`,i._`${t}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`/^\\/[^\\/]*$/.test(${t}.schemaPath.slice(${b.errSchemaPath.length}))`)}function A(t,e){const i=[];for(const n in t){const t=e[n];d.test(t)&&i.push([n,x(t)])}return n.object(...i)}function S(t){return d.test(t)?new r._Code(r.safeStringify(t).replace(p,((t,e)=>`" + JSON.stringify(${s.getData(e,b)}) + "`)).replace(m,"")):i.stringify(t)}function x(t){return i._`function(){return ${S(t)}}`}n.if(i._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[r,s]=function(t){let e,n;for(const i in t){if("properties"===i||"items"===i)continue;const o=t[i];if("object"==typeof o){e||(e={});const t=e[i]={};for(const e in o)t[e]=[]}else n||(n={}),n[i]=[]}return[e,n]}(v);s&&function(o){const r=n.const("emErrors",i.stringify(o)),s=n.const("templates",A(o,g));n.forOf("err",l.default.vErrors,(t=>n.if(C(t,r),(()=>n.code(i._`${r}[${t}.keyword].push(${t})`).assign(i._`${t}.${h}`,!0)))));const{singleError:c}=t;if(c){const t=n.let("message",i._`""`),o=n.let("paramsErrors",i._`[]`);u((e=>{n.if(t,(()=>n.code(i._`${t} += ${"string"==typeof c?c:";"}`))),n.code(i._`${t} += ${d(e)}`),n.assign(o,i._`${o}.concat(${r}[${e}])`)})),a.reportError(e,{message:t,params:i._`{errors: ${o}}`})}else u((t=>a.reportError(e,{message:d(t),params:i._`{errors: ${r}[${t}]}`})));function u(t){n.forIn("key",r,(e=>n.if(i._`${r}[${e}].length`,(()=>t(e)))))}function d(t){return i._`${t} in ${s} ? ${s}[${t}]() : ${y}[${t}]`}}(s),r&&function(t){const o=n.const("emErrors",i.stringify(t)),r=[];for(const e in t)r.push([e,A(t[e],g[e])]);const s=n.const("templates",n.object(...r)),c=n.scopeValue("obj",{ref:u,code:i.stringify(u)}),d=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(t=>n.if(C(t,o),(()=>{n.assign(d,i._`${c}[${t}.keyword]`),n.assign(p,i._`${o}[${t}.keyword][${t}.params[${d}]]`),n.if(p,(()=>n.code(i._`${p}.push(${t})`).assign(i._`${t}.${h}`,!0)))})))),n.forIn("key",o,(t=>n.forIn("keyProp",i._`${o}[${t}]`,(r=>{n.assign(p,i._`${o}[${t}][${r}]`),n.if(i._`${p}.length`,(()=>{const o=n.const("tmpl",i._`${s}[${t}] && ${s}[${t}][${r}]`);a.reportError(e,{message:i._`${o} ? ${o}() : ${y}[${t}][${r}]`,params:i._`{errors: ${p}}`})}))}))))}(r),function(t){const{props:r,items:s}=t;if(!r&&!s)return;const u=i._`typeof ${f} == "object"`,d=i._`Array.isArray(${f})`,p=n.let("emErrors");let m,b;const v=n.let("templates");function C(t,e){n.assign(p,i.stringify(t)),n.assign(v,A(t,e))}r&&s?(m=n.let("emChildKwd"),n.if(u),n.if(d,(()=>{C(s,g.items),n.assign(m,i.str`items`)}),(()=>{C(r,g.properties),n.assign(m,i.str`properties`)})),b=i._`[${m}]`):s?(n.if(d),C(s,g.items),b=i._`.items`):r&&(n.if(o.and(u,o.not(d))),C(r,g.properties),b=i._`.properties`),n.forOf("err",l.default.vErrors,(t=>function(t,e,r){n.if(o.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,i._`${t}.instancePath.indexOf(${w}) === 0`),(()=>{const o=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:i._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),s=n.const("emMatches",i._`${o}.exec(${t}.instancePath.slice(${w}.length))`),a=n.const("emChild",i._`${s} && ${s}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(i._`${a} !== undefined && ${a} in ${e}`,(()=>r(a)))}))}(t,p,(e=>n.code(i._`${p}[${e}].push(${t})`).assign(i._`${t}.${h}`,!0))))),n.forIn("key",p,(t=>n.if(i._`${p}[${t}].length`,(()=>{a.reportError(e,{message:i._`${t} in ${v} ? ${v}[${t}]() : ${y}${b}[${t}]`,params:i._`{errors: ${p}[${t}]}`}),n.assign(i._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,i._`${w} + "/" + ${t}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:t,items:e}){const n={};if(t){n.props={};for(const e in t)n.props[e]=[]}if(e){n.items={};for(let t=0;t<e.length;t++)n.items[t]=[]}return n}(v))}const r="string"==typeof v?v:v._;r&&function(t){const r=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(function(t){return o.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,o.or(i._`${t}.instancePath === ${w}`,o.and(i._`${t}.instancePath.indexOf(${w}) === 0`,i._`${t}.instancePath[${w}.length] === "/"`)),i._`${t}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`${t}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(t),(()=>n.code(i._`${r}.push(${t})`).assign(i._`${t}.${h}`,!0))))),n.if(i._`${r}.length`,(()=>a.reportError(e,{message:S(t),params:i._`{errors: ${r}}`})))}(r),t.keepErrors||function(){const t=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(i._`!${e}.${h}`,(()=>n.code(i._`${t}.push(${e})`))))),n.assign(l.default.vErrors,t).assign(l.default.errors,i._`${t}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(e))};e.default=f,t.exports=f,t.exports.default=f},7433:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MissingRefError=e.ValidationError=e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=e.Ajv2020=void 0;const i=n(4042),o=n(6105),r=n(6653),s=n(9572),a="https://json-schema.org/draft/2020-12/schema";class l extends i.default{constructor(t={}){super({...t,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),o.default.forEach((t=>this.addVocabulary(t))),this.opts.discriminator&&this.addKeyword(r.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:t,meta:e}=this.opts;e&&(s.default.call(this,t),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}e.Ajv2020=l,t.exports=e=l,t.exports.Ajv2020=l,Object.defineProperty(e,"__esModule",{value:!0}),e.default=l;var c=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var h=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var u=n(3558);Object.defineProperty(e,"ValidationError",{enumerable:!0,get:function(){return u.default}});var d=n(4551);Object.defineProperty(e,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},3282:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MissingRefError=e.ValidationError=e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=e.Ajv=void 0;const i=n(4042),o=n(6144),r=n(6653),s=n(2079),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends i.default{_addVocabularies(){super._addVocabularies(),o.default.forEach((t=>this.addVocabulary(t))),this.opts.discriminator&&this.addKeyword(r.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const t=this.opts.$data?this.$dataMetaSchema(s,a):s;this.addMetaSchema(t,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}e.Ajv=c,t.exports=e=c,t.exports.Ajv=c,Object.defineProperty(e,"__esModule",{value:!0}),e.default=c;var h=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return h.KeywordCxt}});var u=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var d=n(3558);Object.defineProperty(e,"ValidationError",{enumerable:!0,get:function(){return d.default}});var p=n(4551);Object.defineProperty(e,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.regexpCode=e.getEsmExportName=e.getProperty=e.safeStringify=e.stringify=e.strConcat=e.addCodeArg=e.str=e._=e.nil=e._Code=e.Name=e.IDENTIFIER=e._CodeOrName=void 0;class n{}e._CodeOrName=n,e.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class i extends n{constructor(t){if(super(),!e.IDENTIFIER.test(t))throw new Error("CodeGen: name must be a valid identifier");this.str=t}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}e.Name=i;class o extends n{constructor(t){super(),this._items="string"==typeof t?[t]:t}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const t=this._items[0];return""===t||'""'===t}get str(){var t;return null!==(t=this._str)&&void 0!==t?t:this._str=this._items.reduce(((t,e)=>`${t}${e}`),"")}get names(){var t;return null!==(t=this._names)&&void 0!==t?t:this._names=this._items.reduce(((t,e)=>(e instanceof i&&(t[e.str]=(t[e.str]||0)+1),t)),{})}}function r(t,...e){const n=[t[0]];let i=0;for(;i<e.length;)l(n,e[i]),n.push(t[++i]);return new o(n)}e._Code=o,e.nil=new o(""),e._=r;const s=new o("+");function a(t,...e){const n=[h(t[0])];let i=0;for(;i<e.length;)n.push(s),l(n,e[i]),n.push(s,h(t[++i]));return function(t){let e=1;for(;e<t.length-1;){if(t[e]===s){const n=c(t[e-1],t[e+1]);if(void 0!==n){t.splice(e-1,3,n);continue}t[e++]="+"}e++}}(n),new o(n)}function l(t,e){var n;e instanceof o?t.push(...e._items):e instanceof i?t.push(e):t.push("number"==typeof(n=e)||"boolean"==typeof n||null===n?n:h(Array.isArray(n)?n.join(","):n))}function c(t,e){if('""'===e)return t;if('""'===t)return e;if("string"==typeof t){if(e instanceof i||'"'!==t[t.length-1])return;return"string"!=typeof e?`${t.slice(0,-1)}${e}"`:'"'===e[0]?t.slice(0,-1)+e.slice(1):void 0}return"string"!=typeof e||'"'!==e[0]||t instanceof i?void 0:`"${t}${e.slice(1)}`}function h(t){return JSON.stringify(t).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}e.str=a,e.addCodeArg=l,e.strConcat=function(t,e){return e.emptyStr()?t:t.emptyStr()?e:a`${t}${e}`},e.stringify=function(t){return new o(h(t))},e.safeStringify=h,e.getProperty=function(t){return"string"==typeof t&&e.IDENTIFIER.test(t)?new o(`.${t}`):r`[${t}]`},e.getEsmExportName=function(t){if("string"==typeof t&&e.IDENTIFIER.test(t))return new o(`${t}`);throw new Error(`CodeGen: invalid export name: ${t}, use explicit $id name mapping`)},e.regexpCode=function(t){return new o(t.toString())}},9029:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.or=e.and=e.not=e.CodeGen=e.operators=e.varKinds=e.ValueScopeName=e.ValueScope=e.Scope=e.Name=e.regexpCode=e.stringify=e.getProperty=e.nil=e.strConcat=e.str=e._=void 0;const i=n(1520),o=n(7845);var r=n(1520);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return r._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return r.str}}),Object.defineProperty(e,"strConcat",{enumerable:!0,get:function(){return r.strConcat}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return r.nil}}),Object.defineProperty(e,"getProperty",{enumerable:!0,get:function(){return r.getProperty}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return r.stringify}}),Object.defineProperty(e,"regexpCode",{enumerable:!0,get:function(){return r.regexpCode}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return r.Name}});var s=n(7845);Object.defineProperty(e,"Scope",{enumerable:!0,get:function(){return s.Scope}}),Object.defineProperty(e,"ValueScope",{enumerable:!0,get:function(){return s.ValueScope}}),Object.defineProperty(e,"ValueScopeName",{enumerable:!0,get:function(){return s.ValueScopeName}}),Object.defineProperty(e,"varKinds",{enumerable:!0,get:function(){return s.varKinds}}),e.operators={GT:new i._Code(">"),GTE:new i._Code(">="),LT:new i._Code("<"),LTE:new i._Code("<="),EQ:new i._Code("==="),NEQ:new i._Code("!=="),NOT:new i._Code("!"),OR:new i._Code("||"),AND:new i._Code("&&"),ADD:new i._Code("+")};class a{optimizeNodes(){return this}optimizeNames(t,e){return this}}class l extends a{constructor(t,e,n){super(),this.varKind=t,this.name=e,this.rhs=n}render({es5:t,_n:e}){const n=t?o.varKinds.var:this.varKind,i=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${i};`+e}optimizeNames(t,e){if(t[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,t,e)),this}get names(){return this.rhs instanceof i._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(t,e,n){super(),this.lhs=t,this.rhs=e,this.sideEffects=n}render({_n:t}){return`${this.lhs} = ${this.rhs};`+t}optimizeNames(t,e){if(!(this.lhs instanceof i.Name)||t[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,t,e),this}get names(){return L(this.lhs instanceof i.Name?{}:{...this.lhs.names},this.rhs)}}class h extends c{constructor(t,e,n,i){super(t,n,i),this.op=e}render({_n:t}){return`${this.lhs} ${this.op}= ${this.rhs};`+t}}class u extends a{constructor(t){super(),this.label=t,this.names={}}render({_n:t}){return`${this.label}:`+t}}class d extends a{constructor(t){super(),this.label=t,this.names={}}render({_n:t}){return`break${this.label?` ${this.label}`:""};`+t}}class p extends a{constructor(t){super(),this.error=t}render({_n:t}){return`throw ${this.error};`+t}get names(){return this.error.names}}class m extends a{constructor(t){super(),this.code=t}render({_n:t}){return`${this.code};`+t}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(t,e){return this.code=N(this.code,t,e),this}get names(){return this.code instanceof i._CodeOrName?this.code.names:{}}}class f extends a{constructor(t=[]){super(),this.nodes=t}render(t){return this.nodes.reduce(((e,n)=>e+n.render(t)),"")}optimizeNodes(){const{nodes:t}=this;let e=t.length;for(;e--;){const n=t[e].optimizeNodes();Array.isArray(n)?t.splice(e,1,...n):n?t[e]=n:t.splice(e,1)}return t.length>0?this:void 0}optimizeNames(t,e){const{nodes:n}=this;let i=n.length;for(;i--;){const o=n[i];o.optimizeNames(t,e)||(P(t,o.names),n.splice(i,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((t,e)=>I(t,e.names)),{})}}class g extends f{render(t){return"{"+t._n+super.render(t)+"}"+t._n}}class y extends f{}class b extends g{}b.kind="else";class v extends g{constructor(t,e){super(e),this.condition=t}render(t){let e=`if(${this.condition})`+super.render(t);return this.else&&(e+="else "+this.else.render(t)),e}optimizeNodes(){super.optimizeNodes();const t=this.condition;if(!0===t)return this.nodes;let e=this.else;if(e){const t=e.optimizeNodes();e=this.else=Array.isArray(t)?new b(t):t}return e?!1===t?e instanceof v?e:e.nodes:this.nodes.length?this:new v($(t),e instanceof v?[e]:e.nodes):!1!==t&&this.nodes.length?this:void 0}optimizeNames(t,e){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(t,e),super.optimizeNames(t,e)||this.else)return this.condition=N(this.condition,t,e),this}get names(){const t=super.names;return L(t,this.condition),this.else&&I(t,this.else.names),t}}v.kind="if";class w extends g{}w.kind="for";class C extends w{constructor(t){super(),this.iteration=t}render(t){return`for(${this.iteration})`+super.render(t)}optimizeNames(t,e){if(super.optimizeNames(t,e))return this.iteration=N(this.iteration,t,e),this}get names(){return I(super.names,this.iteration.names)}}class A extends w{constructor(t,e,n,i){super(),this.varKind=t,this.name=e,this.from=n,this.to=i}render(t){const e=t.es5?o.varKinds.var:this.varKind,{name:n,from:i,to:r}=this;return`for(${e} ${n}=${i}; ${n}<${r}; ${n}++)`+super.render(t)}get names(){const t=L(super.names,this.from);return L(t,this.to)}}class S extends w{constructor(t,e,n,i){super(),this.loop=t,this.varKind=e,this.name=n,this.iterable=i}render(t){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(t)}optimizeNames(t,e){if(super.optimizeNames(t,e))return this.iterable=N(this.iterable,t,e),this}get names(){return I(super.names,this.iterable.names)}}class x extends g{constructor(t,e,n){super(),this.name=t,this.args=e,this.async=n}render(t){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(t)}}x.kind="func";class E extends f{render(t){return"return "+super.render(t)}}E.kind="return";class T extends g{render(t){let e="try"+super.render(t);return this.catch&&(e+=this.catch.render(t)),this.finally&&(e+=this.finally.render(t)),e}optimizeNodes(){var t,e;return super.optimizeNodes(),null===(t=this.catch)||void 0===t||t.optimizeNodes(),null===(e=this.finally)||void 0===e||e.optimizeNodes(),this}optimizeNames(t,e){var n,i;return super.optimizeNames(t,e),null===(n=this.catch)||void 0===n||n.optimizeNames(t,e),null===(i=this.finally)||void 0===i||i.optimizeNames(t,e),this}get names(){const t=super.names;return this.catch&&I(t,this.catch.names),this.finally&&I(t,this.finally.names),t}}class M extends g{constructor(t){super(),this.error=t}render(t){return`catch(${this.error})`+super.render(t)}}M.kind="catch";class _ extends g{render(t){return"finally"+super.render(t)}}function I(t,e){for(const n in e)t[n]=(t[n]||0)+(e[n]||0);return t}function L(t,e){return e instanceof i._CodeOrName?I(t,e.names):t}function N(t,e,n){return t instanceof i.Name?r(t):(o=t)instanceof i._Code&&o._items.some((t=>t instanceof i.Name&&1===e[t.str]&&void 0!==n[t.str]))?new i._Code(t._items.reduce(((t,e)=>(e instanceof i.Name&&(e=r(e)),e instanceof i._Code?t.push(...e._items):t.push(e),t)),[])):t;var o;function r(t){const i=n[t.str];return void 0===i||1!==e[t.str]?t:(delete e[t.str],i)}}function P(t,e){for(const n in e)t[n]=(t[n]||0)-(e[n]||0)}function $(t){return"boolean"==typeof t||"number"==typeof t||null===t?!t:i._`!${H(t)}`}_.kind="finally",e.CodeGen=class{constructor(t,e={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...e,_n:e.lines?"\n":""},this._extScope=t,this._scope=new o.Scope({parent:t}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(t){return this._scope.name(t)}scopeName(t){return this._extScope.name(t)}scopeValue(t,e){const n=this._extScope.value(t,e);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(t,e){return this._extScope.getValue(t,e)}scopeRefs(t){return this._extScope.scopeRefs(t,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(t,e,n,i){const o=this._scope.toName(e);return void 0!==n&&i&&(this._constants[o.str]=n),this._leafNode(new l(t,o,n)),o}const(t,e,n){return this._def(o.varKinds.const,t,e,n)}let(t,e,n){return this._def(o.varKinds.let,t,e,n)}var(t,e,n){return this._def(o.varKinds.var,t,e,n)}assign(t,e,n){return this._leafNode(new c(t,e,n))}add(t,n){return this._leafNode(new h(t,e.operators.ADD,n))}code(t){return"function"==typeof t?t():t!==i.nil&&this._leafNode(new m(t)),this}object(...t){const e=["{"];for(const[n,o]of t)e.length>1&&e.push(","),e.push(n),(n!==o||this.opts.es5)&&(e.push(":"),(0,i.addCodeArg)(e,o));return e.push("}"),new i._Code(e)}if(t,e,n){if(this._blockNode(new v(t)),e&&n)this.code(e).else().code(n).endIf();else if(e)this.code(e).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(t){return this._elseNode(new v(t))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(t,e){return this._blockNode(t),e&&this.code(e).endFor(),this}for(t,e){return this._for(new C(t),e)}forRange(t,e,n,i,r=(this.opts.es5?o.varKinds.var:o.varKinds.let)){const s=this._scope.toName(t);return this._for(new A(r,s,e,n),(()=>i(s)))}forOf(t,e,n,r=o.varKinds.const){const s=this._scope.toName(t);if(this.opts.es5){const t=e instanceof i.Name?e:this.var("_arr",e);return this.forRange("_i",0,i._`${t}.length`,(e=>{this.var(s,i._`${t}[${e}]`),n(s)}))}return this._for(new S("of",r,s,e),(()=>n(s)))}forIn(t,e,n,r=(this.opts.es5?o.varKinds.var:o.varKinds.const)){if(this.opts.ownProperties)return this.forOf(t,i._`Object.keys(${e})`,n);const s=this._scope.toName(t);return this._for(new S("in",r,s,e),(()=>n(s)))}endFor(){return this._endBlockNode(w)}label(t){return this._leafNode(new u(t))}break(t){return this._leafNode(new d(t))}return(t){const e=new E;if(this._blockNode(e),this.code(t),1!==e.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(E)}try(t,e,n){if(!e&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const i=new T;if(this._blockNode(i),this.code(t),e){const t=this.name("e");this._currNode=i.catch=new M(t),e(t)}return n&&(this._currNode=i.finally=new _,this.code(n)),this._endBlockNode(M,_)}throw(t){return this._leafNode(new p(t))}block(t,e){return this._blockStarts.push(this._nodes.length),t&&this.code(t).endBlock(e),this}endBlock(t){const e=this._blockStarts.pop();if(void 0===e)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-e;if(n<0||void 0!==t&&n!==t)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${t} expected`);return this._nodes.length=e,this}func(t,e=i.nil,n,o){return this._blockNode(new x(t,e,n)),o&&this.code(o).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(t=1){for(;t-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(t){return this._currNode.nodes.push(t),this}_blockNode(t){this._currNode.nodes.push(t),this._nodes.push(t)}_endBlockNode(t,e){const n=this._currNode;if(n instanceof t||e&&n instanceof e)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${e?`${t.kind}/${e.kind}`:t.kind}"`)}_elseNode(t){const e=this._currNode;if(!(e instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=e.else=t,this}get _root(){return this._nodes[0]}get _currNode(){const t=this._nodes;return t[t.length-1]}set _currNode(t){const e=this._nodes;e[e.length-1]=t}},e.not=$;const R=O(e.operators.AND);e.and=function(...t){return t.reduce(R)};const k=O(e.operators.OR);function O(t){return(e,n)=>e===i.nil?n:n===i.nil?e:i._`${H(e)} ${t} ${H(n)}`}function H(t){return t instanceof i.Name?t:i._`(${t})`}e.or=function(...t){return t.reduce(k)}},7845:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.ValueScope=e.ValueScopeName=e.Scope=e.varKinds=e.UsedValueState=void 0;const i=n(1520);class o extends Error{constructor(t){super(`CodeGen: "code" for ${t} not defined`),this.value=t.value}}var r;!function(t){t[t.Started=0]="Started",t[t.Completed=1]="Completed"}(r||(e.UsedValueState=r={})),e.varKinds={const:new i.Name("const"),let:new i.Name("let"),var:new i.Name("var")};class s{constructor({prefixes:t,parent:e}={}){this._names={},this._prefixes=t,this._parent=e}toName(t){return t instanceof i.Name?t:this.name(t)}name(t){return new i.Name(this._newName(t))}_newName(t){return`${t}${(this._names[t]||this._nameGroup(t)).index++}`}_nameGroup(t){var e,n;if((null===(n=null===(e=this._parent)||void 0===e?void 0:e._prefixes)||void 0===n?void 0:n.has(t))||this._prefixes&&!this._prefixes.has(t))throw new Error(`CodeGen: prefix "${t}" is not allowed in this scope`);return this._names[t]={prefix:t,index:0}}}e.Scope=s;class a extends i.Name{constructor(t,e){super(e),this.prefix=t}setValue(t,{property:e,itemIndex:n}){this.value=t,this.scopePath=i._`.${new i.Name(e)}[${n}]`}}e.ValueScopeName=a;const l=i._`\n`;e.ValueScope=class extends s{constructor(t){super(t),this._values={},this._scope=t.scope,this.opts={...t,_n:t.lines?l:i.nil}}get(){return this._scope}name(t){return new a(t,this._newName(t))}value(t,e){var n;if(void 0===e.ref)throw new Error("CodeGen: ref must be passed in value");const i=this.toName(t),{prefix:o}=i,r=null!==(n=e.key)&&void 0!==n?n:e.ref;let s=this._values[o];if(s){const t=s.get(r);if(t)return t}else s=this._values[o]=new Map;s.set(r,i);const a=this._scope[o]||(this._scope[o]=[]),l=a.length;return a[l]=e.ref,i.setValue(e,{property:o,itemIndex:l}),i}getValue(t,e){const n=this._values[t];if(n)return n.get(e)}scopeRefs(t,e=this._values){return this._reduceValues(e,(e=>{if(void 0===e.scopePath)throw new Error(`CodeGen: name "${e}" has no value`);return i._`${t}${e.scopePath}`}))}scopeCode(t=this._values,e,n){return this._reduceValues(t,(t=>{if(void 0===t.value)throw new Error(`CodeGen: name "${t}" has no value`);return t.value.code}),e,n)}_reduceValues(t,n,s={},a){let l=i.nil;for(const c in t){const h=t[c];if(!h)continue;const u=s[c]=s[c]||new Map;h.forEach((t=>{if(u.has(t))return;u.set(t,r.Started);let s=n(t);if(s){const n=this.opts.es5?e.varKinds.var:e.varKinds.const;l=i._`${l}${n} ${t} = ${s};${this.opts._n}`}else{if(!(s=null==a?void 0:a(t)))throw new o(t);l=i._`${l}${s}${this.opts._n}`}u.set(t,r.Completed)}))}return l}}},8708:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.extendErrors=e.resetErrorsCount=e.reportExtraError=e.reportError=e.keyword$DataError=e.keywordError=void 0;const i=n(9029),o=n(4227),r=n(2023);function s(t,e){const n=t.const("err",e);t.if(i._`${r.default.vErrors} === null`,(()=>t.assign(r.default.vErrors,i._`[${n}]`)),i._`${r.default.vErrors}.push(${n})`),t.code(i._`${r.default.errors}++`)}function a(t,e){const{gen:n,validateName:o,schemaEnv:r}=t;r.$async?n.throw(i._`new ${t.ValidationError}(${e})`):(n.assign(i._`${o}.errors`,e),n.return(!1))}e.keywordError={message:({keyword:t})=>i.str`must pass "${t}" keyword validation`},e.keyword$DataError={message:({keyword:t,schemaType:e})=>e?i.str`"${t}" keyword must be ${e} ($data)`:i.str`"${t}" keyword is invalid ($data)`},e.reportError=function(t,n=e.keywordError,o,r){const{it:l}=t,{gen:h,compositeRule:u,allErrors:d}=l,p=c(t,n,o);(null!=r?r:u||d)?s(h,p):a(l,i._`[${p}]`)},e.reportExtraError=function(t,n=e.keywordError,i){const{it:o}=t,{gen:l,compositeRule:h,allErrors:u}=o;s(l,c(t,n,i)),h||u||a(o,r.default.vErrors)},e.resetErrorsCount=function(t,e){t.assign(r.default.errors,e),t.if(i._`${r.default.vErrors} !== null`,(()=>t.if(e,(()=>t.assign(i._`${r.default.vErrors}.length`,e)),(()=>t.assign(r.default.vErrors,null)))))},e.extendErrors=function({gen:t,keyword:e,schemaValue:n,data:o,errsCount:s,it:a}){if(void 0===s)throw new Error("ajv implementation error");const l=t.name("err");t.forRange("i",s,r.default.errors,(s=>{t.const(l,i._`${r.default.vErrors}[${s}]`),t.if(i._`${l}.instancePath === undefined`,(()=>t.assign(i._`${l}.instancePath`,(0,i.strConcat)(r.default.instancePath,a.errorPath)))),t.assign(i._`${l}.schemaPath`,i.str`${a.errSchemaPath}/${e}`),a.opts.verbose&&(t.assign(i._`${l}.schema`,n),t.assign(i._`${l}.data`,o))}))};const l={keyword:new i.Name("keyword"),schemaPath:new i.Name("schemaPath"),params:new i.Name("params"),propertyName:new i.Name("propertyName"),message:new i.Name("message"),schema:new i.Name("schema"),parentSchema:new i.Name("parentSchema")};function c(t,e,n){const{createErrors:o}=t.it;return!1===o?i._`{}`:function(t,e,n={}){const{gen:o,it:s}=t,a=[h(s,n),u(t,n)];return function(t,{params:e,message:n},o){const{keyword:s,data:a,schemaValue:c,it:h}=t,{opts:u,propertyName:d,topSchemaRef:p,schemaPath:m}=h;o.push([l.keyword,s],[l.params,"function"==typeof e?e(t):e||i._`{}`]),u.messages&&o.push([l.message,"function"==typeof n?n(t):n]),u.verbose&&o.push([l.schema,c],[l.parentSchema,i._`${p}${m}`],[r.default.data,a]),d&&o.push([l.propertyName,d])}(t,e,a),o.object(...a)}(t,e,n)}function h({errorPath:t},{instancePath:e}){const n=e?i.str`${t}${(0,o.getErrorPath)(e,o.Type.Str)}`:t;return[r.default.instancePath,(0,i.strConcat)(r.default.instancePath,n)]}function u({keyword:t,it:{errSchemaPath:e}},{schemaPath:n,parentSchema:r}){let s=r?e:i.str`${e}/${t}`;return n&&(s=i.str`${s}${(0,o.getErrorPath)(n,o.Type.Str)}`),[l.schemaPath,s]}},3835:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.resolveSchema=e.getCompilingSchema=e.resolveRef=e.compileSchema=e.SchemaEnv=void 0;const i=n(9029),o=n(3558),r=n(2023),s=n(6939),a=n(4227),l=n(2586);class c{constructor(t){var e;let n;this.refs={},this.dynamicAnchors={},"object"==typeof t.schema&&(n=t.schema),this.schema=t.schema,this.schemaId=t.schemaId,this.root=t.root||this,this.baseId=null!==(e=t.baseId)&&void 0!==e?e:(0,s.normalizeId)(null==n?void 0:n[t.schemaId||"$id"]),this.schemaPath=t.schemaPath,this.localRefs=t.localRefs,this.meta=t.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function h(t){const e=d.call(this,t);if(e)return e;const n=(0,s.getFullPath)(this.opts.uriResolver,t.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:h}=this.opts,u=new i.CodeGen(this.scope,{es5:a,lines:c,ownProperties:h});let p;t.$async&&(p=u.scopeValue("Error",{ref:o.default,code:i._`require("ajv/dist/runtime/validation_error").default`}));const m=u.scopeName("validate");t.validateName=m;const f={gen:u,allErrors:this.opts.allErrors,data:r.default.data,parentData:r.default.parentData,parentDataProperty:r.default.parentDataProperty,dataNames:[r.default.data],dataPathArr:[i.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:u.scopeValue("schema",!0===this.opts.code.source?{ref:t.schema,code:(0,i.stringify)(t.schema)}:{ref:t.schema}),validateName:m,ValidationError:p,schema:t.schema,schemaEnv:t,rootId:n,baseId:t.baseId||n,schemaPath:i.nil,errSchemaPath:t.schemaPath||(this.opts.jtd?"":"#"),errorPath:i._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(t),(0,l.validateFunctionCode)(f),u.optimize(this.opts.code.optimize);const e=u.toString();g=`${u.scopeRefs(r.default.scope)}return ${e}`,this.opts.code.process&&(g=this.opts.code.process(g,t));const n=new Function(`${r.default.self}`,`${r.default.scope}`,g)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=t.schema,n.schemaEnv=t,t.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:e,scopeValues:u._values}),this.opts.unevaluated){const{props:t,items:e}=f;n.evaluated={props:t instanceof i.Name?void 0:t,items:e instanceof i.Name?void 0:e,dynamicProps:t instanceof i.Name,dynamicItems:e instanceof i.Name},n.source&&(n.source.evaluated=(0,i.stringify)(n.evaluated))}return t.validate=n,t}catch(e){throw delete t.validate,delete t.validateName,g&&this.logger.error("Error compiling schema, function code:",g),e}finally{this._compilations.delete(t)}}function u(t){return(0,s.inlineRef)(t.schema,this.opts.inlineRefs)?t.schema:t.validate?t:h.call(this,t)}function d(t){for(const i of this._compilations)if(n=t,(e=i).schema===n.schema&&e.root===n.root&&e.baseId===n.baseId)return i;var e,n}function p(t,e){let n;for(;"string"==typeof(n=this.refs[e]);)e=n;return n||this.schemas[e]||m.call(this,t,e)}function m(t,e){const n=this.opts.uriResolver.parse(e),i=(0,s._getFullPath)(this.opts.uriResolver,n);let o=(0,s.getFullPath)(this.opts.uriResolver,t.baseId,void 0);if(Object.keys(t.schema).length>0&&i===o)return g.call(this,n,t);const r=(0,s.normalizeId)(i),a=this.refs[r]||this.schemas[r];if("string"==typeof a){const e=m.call(this,t,a);if("object"!=typeof(null==e?void 0:e.schema))return;return g.call(this,n,e)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||h.call(this,a),r===(0,s.normalizeId)(e)){const{schema:e}=a,{schemaId:n}=this.opts,i=e[n];return i&&(o=(0,s.resolveUrl)(this.opts.uriResolver,o,i)),new c({schema:e,schemaId:n,root:t,baseId:o})}return g.call(this,n,a)}}e.SchemaEnv=c,e.compileSchema=h,e.resolveRef=function(t,e,n){var i;n=(0,s.resolveUrl)(this.opts.uriResolver,e,n);const o=t.refs[n];if(o)return o;let r=p.call(this,t,n);if(void 0===r){const o=null===(i=t.localRefs)||void 0===i?void 0:i[n],{schemaId:s}=this.opts;o&&(r=new c({schema:o,schemaId:s,root:t,baseId:e}))}return void 0!==r?t.refs[n]=u.call(this,r):void 0},e.getCompilingSchema=d,e.resolveSchema=m;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(t,{baseId:e,schema:n,root:i}){var o;if("/"!==(null===(o=t.fragment)||void 0===o?void 0:o[0]))return;for(const i of t.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const t=n[(0,a.unescapeFragment)(i)];if(void 0===t)return;const o="object"==typeof(n=t)&&n[this.opts.schemaId];!f.has(i)&&o&&(e=(0,s.resolveUrl)(this.opts.uriResolver,e,o))}let r;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const t=(0,s.resolveUrl)(this.opts.uriResolver,e,n.$ref);r=m.call(this,i,t)}const{schemaId:l}=this.opts;return r=r||new c({schema:n,schemaId:l,root:i,baseId:e}),r.schema!==r.root.schema?r:void 0}},2023:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o={data:new i.Name("data"),valCxt:new i.Name("valCxt"),instancePath:new i.Name("instancePath"),parentData:new i.Name("parentData"),parentDataProperty:new i.Name("parentDataProperty"),rootData:new i.Name("rootData"),dynamicAnchors:new i.Name("dynamicAnchors"),vErrors:new i.Name("vErrors"),errors:new i.Name("errors"),this:new i.Name("this"),self:new i.Name("self"),scope:new i.Name("scope"),json:new i.Name("json"),jsonPos:new i.Name("jsonPos"),jsonLen:new i.Name("jsonLen"),jsonPart:new i.Name("jsonPart")};e.default=o},4551:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(6939);class o extends Error{constructor(t,e,n,o){super(o||`can't resolve reference ${n} from id ${e}`),this.missingRef=(0,i.resolveUrl)(t,e,n),this.missingSchema=(0,i.normalizeId)((0,i.getFullPath)(t,this.missingRef))}}e.default=o},6939:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getSchemaRefs=e.resolveUrl=e.normalizeId=e._getFullPath=e.getFullPath=e.inlineRef=void 0;const i=n(4227),o=n(2017),r=n(7106),s=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);e.inlineRef=function(t,e=!0){return"boolean"==typeof t||(!0===e?!l(t):!!e&&c(t)<=e)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(t){for(const e in t){if(a.has(e))return!0;const n=t[e];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(t){let e=0;for(const n in t){if("$ref"===n)return 1/0;if(e++,!s.has(n)&&("object"==typeof t[n]&&(0,i.eachItem)(t[n],(t=>e+=c(t))),e===1/0))return 1/0}return e}function h(t,e="",n){!1!==n&&(e=p(e));const i=t.parse(e);return u(t,i)}function u(t,e){return t.serialize(e).split("#")[0]+"#"}e.getFullPath=h,e._getFullPath=u;const d=/#\/?$/;function p(t){return t?t.replace(d,""):""}e.normalizeId=p,e.resolveUrl=function(t,e,n){return n=p(n),t.resolve(e,n)};const m=/^[a-z_][-a-z0-9._]*$/i;e.getSchemaRefs=function(t,e){if("boolean"==typeof t)return{};const{schemaId:n,uriResolver:i}=this.opts,s=p(t[n]||e),a={"":s},l=h(i,s,!1),c={},u=new Set;return r(t,{allKeys:!0},((t,e,i,o)=>{if(void 0===o)return;const r=l+e;let s=a[o];function h(e){const n=this.opts.uriResolver.resolve;if(e=p(s?n(s,e):e),u.has(e))throw f(e);u.add(e);let i=this.refs[e];return"string"==typeof i&&(i=this.refs[i]),"object"==typeof i?d(t,i.schema,e):e!==p(r)&&("#"===e[0]?(d(t,c[e],e),c[e]=t):this.refs[e]=r),e}function g(t){if("string"==typeof t){if(!m.test(t))throw new Error(`invalid anchor "${t}"`);h.call(this,`#${t}`)}}"string"==typeof t[n]&&(s=h.call(this,t[n])),g.call(this,t.$anchor),g.call(this,t.$dynamicAnchor),a[e]=s})),c;function d(t,e,n){if(void 0!==e&&!o(t,e))throw f(n)}function f(t){return new Error(`reference "${t}" resolves to more than one schema`)}}},396:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getRules=e.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);e.isJSONType=function(t){return"string"==typeof t&&n.has(t)},e.getRules=function(){const t={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...t,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},t.number,t.string,t.array,t.object],post:{rules:[]},all:{},keywords:{}}}},4227:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.checkStrictMode=e.getErrorPath=e.Type=e.useFunc=e.setEvaluated=e.evaluatedPropsToName=e.mergeEvaluated=e.eachItem=e.unescapeJsonPointer=e.escapeJsonPointer=e.escapeFragment=e.unescapeFragment=e.schemaRefOrVal=e.schemaHasRulesButRef=e.schemaHasRules=e.checkUnknownRules=e.alwaysValidSchema=e.toHash=void 0;const i=n(9029),o=n(1520);function r(t,e=t.schema){const{opts:n,self:i}=t;if(!n.strictSchema)return;if("boolean"==typeof e)return;const o=i.RULES.keywords;for(const n in e)o[n]||m(t,`unknown keyword: "${n}"`)}function s(t,e){if("boolean"==typeof t)return!t;for(const n in t)if(e[n])return!0;return!1}function a(t){return"number"==typeof t?`${t}`:t.replace(/~/g,"~0").replace(/\//g,"~1")}function l(t){return t.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:t,mergeToName:e,mergeValues:n,resultToName:o}){return(r,s,a,l)=>{const c=void 0===a?s:a instanceof i.Name?(s instanceof i.Name?t(r,s,a):e(r,s,a),a):s instanceof i.Name?(e(r,a,s),s):n(s,a);return l!==i.Name||c instanceof i.Name?c:o(r,c)}}function h(t,e){if(!0===e)return t.var("props",!0);const n=t.var("props",i._`{}`);return void 0!==e&&u(t,n,e),n}function u(t,e,n){Object.keys(n).forEach((n=>t.assign(i._`${e}${(0,i.getProperty)(n)}`,!0)))}e.toHash=function(t){const e={};for(const n of t)e[n]=!0;return e},e.alwaysValidSchema=function(t,e){return"boolean"==typeof e?e:0===Object.keys(e).length||(r(t,e),!s(e,t.self.RULES.all))},e.checkUnknownRules=r,e.schemaHasRules=s,e.schemaHasRulesButRef=function(t,e){if("boolean"==typeof t)return!t;for(const n in t)if("$ref"!==n&&e.all[n])return!0;return!1},e.schemaRefOrVal=function({topSchemaRef:t,schemaPath:e},n,o,r){if(!r){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return i._`${n}`}return i._`${t}${e}${(0,i.getProperty)(o)}`},e.unescapeFragment=function(t){return l(decodeURIComponent(t))},e.escapeFragment=function(t){return encodeURIComponent(a(t))},e.escapeJsonPointer=a,e.unescapeJsonPointer=l,e.eachItem=function(t,e){if(Array.isArray(t))for(const n of t)e(n);else e(t)},e.mergeEvaluated={props:c({mergeNames:(t,e,n)=>t.if(i._`${n} !== true && ${e} !== undefined`,(()=>{t.if(i._`${e} === true`,(()=>t.assign(n,!0)),(()=>t.assign(n,i._`${n} || {}`).code(i._`Object.assign(${n}, ${e})`)))})),mergeToName:(t,e,n)=>t.if(i._`${n} !== true`,(()=>{!0===e?t.assign(n,!0):(t.assign(n,i._`${n} || {}`),u(t,n,e))})),mergeValues:(t,e)=>!0===t||{...t,...e},resultToName:h}),items:c({mergeNames:(t,e,n)=>t.if(i._`${n} !== true && ${e} !== undefined`,(()=>t.assign(n,i._`${e} === true ? true : ${n} > ${e} ? ${n} : ${e}`))),mergeToName:(t,e,n)=>t.if(i._`${n} !== true`,(()=>t.assign(n,!0===e||i._`${n} > ${e} ? ${n} : ${e}`))),mergeValues:(t,e)=>!0===t||Math.max(t,e),resultToName:(t,e)=>t.var("items",e)})},e.evaluatedPropsToName=h,e.setEvaluated=u;const d={};var p;function m(t,e,n=t.opts.strictSchema){if(n){if(e=`strict mode: ${e}`,!0===n)throw new Error(e);t.self.logger.warn(e)}}e.useFunc=function(t,e){return t.scopeValue("func",{ref:e,code:d[e.code]||(d[e.code]=new o._Code(e.code))})},function(t){t[t.Num=0]="Num",t[t.Str=1]="Str"}(p||(e.Type=p={})),e.getErrorPath=function(t,e,n){if(t instanceof i.Name){const o=e===p.Num;return n?o?i._`"[" + ${t} + "]"`:i._`"['" + ${t} + "']"`:o?i._`"/" + ${t}`:i._`"/" + ${t}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,i.getProperty)(t).toString():"/"+a(t)},e.checkStrictMode=m},7887:(t,e)=>{"use strict";function n(t,e){return e.rules.some((e=>i(t,e)))}function i(t,e){var n;return void 0!==t[e.keyword]||(null===(n=e.definition.implements)||void 0===n?void 0:n.some((e=>void 0!==t[e])))}Object.defineProperty(e,"__esModule",{value:!0}),e.shouldUseRule=e.shouldUseGroup=e.schemaHasRulesForType=void 0,e.schemaHasRulesForType=function({schema:t,self:e},i){const o=e.RULES.types[i];return o&&!0!==o&&n(t,o)},e.shouldUseGroup=n,e.shouldUseRule=i},8727:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.boolOrEmptySchema=e.topBoolOrEmptySchema=void 0;const i=n(8708),o=n(9029),r=n(2023),s={message:"boolean schema is false"};function a(t,e){const{gen:n,data:o}=t,r={gen:n,keyword:"false schema",data:o,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:t};(0,i.reportError)(r,s,void 0,e)}e.topBoolOrEmptySchema=function(t){const{gen:e,schema:n,validateName:i}=t;!1===n?a(t,!1):"object"==typeof n&&!0===n.$async?e.return(r.default.data):(e.assign(o._`${i}.errors`,null),e.return(!0))},e.boolOrEmptySchema=function(t,e){const{gen:n,schema:i}=t;!1===i?(n.var(e,!1),a(t)):n.var(e,!0)}},208:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.reportTypeError=e.checkDataTypes=e.checkDataType=e.coerceAndCheckDataType=e.getJSONTypes=e.getSchemaTypes=e.DataType=void 0;const i=n(396),o=n(7887),r=n(8708),s=n(9029),a=n(4227);var l;function c(t){const e=Array.isArray(t)?t:t?[t]:[];if(e.every(i.isJSONType))return e;throw new Error("type must be JSONType or JSONType[]: "+e.join(","))}!function(t){t[t.Correct=0]="Correct",t[t.Wrong=1]="Wrong"}(l||(e.DataType=l={})),e.getSchemaTypes=function(t){const e=c(t.type);if(e.includes("null")){if(!1===t.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!e.length&&void 0!==t.nullable)throw new Error('"nullable" cannot be used without "type"');!0===t.nullable&&e.push("null")}return e},e.getJSONTypes=c,e.coerceAndCheckDataType=function(t,e){const{gen:n,data:i,opts:r}=t,a=function(t,e){return e?t.filter((t=>h.has(t)||"array"===e&&"array"===t)):[]}(e,r.coerceTypes),c=e.length>0&&!(0===a.length&&1===e.length&&(0,o.schemaHasRulesForType)(t,e[0]));if(c){const o=d(e,i,r.strictNumbers,l.Wrong);n.if(o,(()=>{a.length?function(t,e,n){const{gen:i,data:o,opts:r}=t,a=i.let("dataType",s._`typeof ${o}`),l=i.let("coerced",s._`undefined`);"array"===r.coerceTypes&&i.if(s._`${a} == 'object' && Array.isArray(${o}) && ${o}.length == 1`,(()=>i.assign(o,s._`${o}[0]`).assign(a,s._`typeof ${o}`).if(d(e,o,r.strictNumbers),(()=>i.assign(l,o))))),i.if(s._`${l} !== undefined`);for(const t of n)(h.has(t)||"array"===t&&"array"===r.coerceTypes)&&c(t);function c(t){switch(t){case"string":return void i.elseIf(s._`${a} == "number" || ${a} == "boolean"`).assign(l,s._`"" + ${o}`).elseIf(s._`${o} === null`).assign(l,s._`""`);case"number":return void i.elseIf(s._`${a} == "boolean" || ${o} === null
+var bio;(()=>{var e={8924:(e,t,n)=>{"use strict";var i=n(7362);class o extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,o)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,o)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new o({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in o.aaSynonyms?o.aaSynonyms[e]:e;return super.get(t)}}o.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(e="grok"){switch(e){case"grok":return o.GrokGroups;case"lesk":return o.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",i="";for(const o of e)"("==o?t++:")"==o?t--:t?n+=o:i+=o;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[i,o]=this.getInnerOuter(e);if(i=i.length>6?`${i.slice(0,3)}...`:i,o=o.length>6?`${o.slice(0,3)}...`:o,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,o,1]:[this.undefinedColor,i,o,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,o,2]:[this.undefinedColor,i,o,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,o,3]:[this.undefinedColor,i,o,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,o,4]:[this.undefinedColor,i,o,4]}return[this.undefinedColor,i,o,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(e,t,n)=>{"use strict";n.d(t,{j:()=>o});var i=n(6082);async function o(){const e=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===e.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await e[0].prepare().call()).getOutputParamValue()}},3599:(e,t,n)=>{"use strict";n.d(t,{o:()=>i.o});var i=n(6869)},9124:(e,t,n)=>{"use strict";n.d(t,{b2:()=>r,fA:()=>s});var i=n(7389),o=n(6082);async function r(){const e="Helm",t=o.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}function s(e,t){if(!e)throw new Error("Argument 'a' of type Atom or HelmType is mandatory.");let n,i;const o=e;return"ATOM"===o.T?(n=o.biotype(),i=o.elem):(n=e,i=t),[n,i]}o.JsInputBase,Error,i.input.helmAsync=async function(e,t){return(await r()).createHelmInput(e,t)}},8438:(e,t,n)=>{"use strict";function i(e){return e.startsWith("[")&&e.endsWith("]")?e.slice(1,-1):e}n.d(t,{D:()=>i})},8123:(e,t,n)=>{"use strict";n.d(t,{u:()=>i});const i={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M  RGP",V2K_A_LINE:"A  ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:"  0  0  0  0  0  0            999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M  V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M  V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M  V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M  V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M  V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M  V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M  V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M  V30 ",V3K_END:"M  END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:{polymerType:"RNA",symbol:"d"},RIBOSE:{polymerType:"RNA",symbol:"r"},PHOSPHATE:{polymerType:"RNA",symbol:"p"},OXYGEN:"O",HYDROGEN:"H"}},4356:(e,t,n)=>{"use strict";n.d(t,{Eu:()=>a,ub:()=>s});var i=n(4328);const o="Libraries";let r=Promise.resolve();async function s(){let e;return r=r.then((async()=>{const t=i.userSettings.getValue(o,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],e.duplicateMonomerPreferences=e.duplicateMonomerPreferences instanceof Object?e.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await r,e}async function a(e){r=r.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),i.userSettings.add(o,"Settings",JSON.stringify(e),!0)})),await r}},5553:(e,t,n)=>{"use strict";n.d(t,{Qc:()=>S,WN:()=>A});var i=n(1991),o=n.n(i);const r="object"==typeof performance&&performance&&"function"==typeof performance.now?performance:Date,s=new Set,a="object"==typeof process&&process?process:{},l=(e,t,n,i)=>{"function"==typeof a.emitWarning?a.emitWarning(e,t,n,i):console.error(`[${n}] ${t}: ${e}`)};let c=globalThis.AbortController,u=globalThis.AbortSignal;if(void 0===c){u=class{onabort;_onabort=[];reason;aborted=!1;addEventListener(e,t){this._onabort.push(t)}},c=class{constructor(){t()}signal=new u;abort(e){if(!this.signal.aborted){this.signal.reason=e,this.signal.aborted=!0;for(const t of this.signal._onabort)t(e);this.signal.onabort?.(e)}}};let e="1"!==a.env?.LRU_CACHE_IGNORE_AC_WARNING;const t=()=>{e&&(e=!1,l("AbortController is not defined. If using lru-cache in node 14, load an AbortController polyfill from the `node-abort-controller` package. A minimal polyfill is provided for use by LRUCache.fetch(), but it should not be relied upon in other contexts (eg, passing it to other APIs that use AbortController/AbortSignal might have undesirable effects). You may disable this with LRU_CACHE_IGNORE_AC_WARNING=1 in the env.","NO_ABORT_CONTROLLER","ENOTSUP",t))}}Symbol("type");const h=e=>e&&e===Math.floor(e)&&e>0&&isFinite(e),d=e=>h(e)?e<=Math.pow(2,8)?Uint8Array:e<=Math.pow(2,16)?Uint16Array:e<=Math.pow(2,32)?Uint32Array:e<=Number.MAX_SAFE_INTEGER?p:null:null;class p extends Array{constructor(e){super(e),this.fill(0)}}class m{heap;length;static#e=!1;static create(e){const t=d(e);if(!t)return[];m.#e=!0;const n=new m(e,t);return m.#e=!1,n}constructor(e,t){if(!m.#e)throw new TypeError("instantiate Stack using Stack.create(n)");this.heap=new t(e),this.length=0}push(e){this.heap[this.length++]=e}pop(){return this.heap[--this.length]}}class g{#t;#n;#i;#o;#r;#s;ttl;ttlResolution;ttlAutopurge;updateAgeOnGet;updateAgeOnHas;allowStale;noDisposeOnSet;noUpdateTTL;maxEntrySize;sizeCalculation;noDeleteOnFetchRejection;noDeleteOnStaleGet;allowStaleOnFetchAbort;allowStaleOnFetchRejection;ignoreFetchAbort;#a;#l;#c;#u;#h;#d;#p;#m;#g;#f;#y;#b;#v;#w;#C;#S;#A;static unsafeExposeInternals(e){return{starts:e.#v,ttls:e.#w,sizes:e.#b,keyMap:e.#c,keyList:e.#u,valList:e.#h,next:e.#d,prev:e.#p,get head(){return e.#m},get tail(){return e.#g},free:e.#f,isBackgroundFetch:t=>e.#x(t),backgroundFetch:(t,n,i,o)=>e.#M(t,n,i,o),moveToTail:t=>e.#E(t),indexes:t=>e.#T(t),rindexes:t=>e.#_(t),isStale:t=>e.#I(t)}}get max(){return this.#t}get maxSize(){return this.#n}get calculatedSize(){return this.#l}get size(){return this.#a}get fetchMethod(){return this.#r}get memoMethod(){return this.#s}get dispose(){return this.#i}get disposeAfter(){return this.#o}constructor(e){const{max:t=0,ttl:n,ttlResolution:i=1,ttlAutopurge:o,updateAgeOnGet:r,updateAgeOnHas:a,allowStale:c,dispose:u,disposeAfter:p,noDisposeOnSet:f,noUpdateTTL:y,maxSize:b=0,maxEntrySize:v=0,sizeCalculation:w,fetchMethod:C,memoMethod:S,noDeleteOnFetchRejection:A,noDeleteOnStaleGet:x,allowStaleOnFetchRejection:M,allowStaleOnFetchAbort:E,ignoreFetchAbort:T}=e;if(0!==t&&!h(t))throw new TypeError("max option must be a nonnegative integer");const _=t?d(t):Array;if(!_)throw new Error("invalid max value: "+t);if(this.#t=t,this.#n=b,this.maxEntrySize=v||this.#n,this.sizeCalculation=w,this.sizeCalculation){if(!this.#n&&!this.maxEntrySize)throw new TypeError("cannot set sizeCalculation without setting maxSize or maxEntrySize");if("function"!=typeof this.sizeCalculation)throw new TypeError("sizeCalculation set to non-function")}if(void 0!==S&&"function"!=typeof S)throw new TypeError("memoMethod must be a function if defined");if(this.#s=S,void 0!==C&&"function"!=typeof C)throw new TypeError("fetchMethod must be a function if specified");if(this.#r=C,this.#S=!!C,this.#c=new Map,this.#u=new Array(t).fill(void 0),this.#h=new Array(t).fill(void 0),this.#d=new _(t),this.#p=new _(t),this.#m=0,this.#g=0,this.#f=m.create(t),this.#a=0,this.#l=0,"function"==typeof u&&(this.#i=u),"function"==typeof p?(this.#o=p,this.#y=[]):(this.#o=void 0,this.#y=void 0),this.#C=!!this.#i,this.#A=!!this.#o,this.noDisposeOnSet=!!f,this.noUpdateTTL=!!y,this.noDeleteOnFetchRejection=!!A,this.allowStaleOnFetchRejection=!!M,this.allowStaleOnFetchAbort=!!E,this.ignoreFetchAbort=!!T,0!==this.maxEntrySize){if(0!==this.#n&&!h(this.#n))throw new TypeError("maxSize must be a positive integer if specified");if(!h(this.maxEntrySize))throw new TypeError("maxEntrySize must be a positive integer if specified");this.#L()}if(this.allowStale=!!c,this.noDeleteOnStaleGet=!!x,this.updateAgeOnGet=!!r,this.updateAgeOnHas=!!a,this.ttlResolution=h(i)||0===i?i:1,this.ttlAutopurge=!!o,this.ttl=n||0,this.ttl){if(!h(this.ttl))throw new TypeError("ttl must be a positive integer if specified");this.#N()}if(0===this.#t&&0===this.ttl&&0===this.#n)throw new TypeError("At least one of max, maxSize, or ttl is required");if(!this.ttlAutopurge&&!this.#t&&!this.#n){const e="LRU_CACHE_UNBOUNDED";(e=>!s.has(e))(e)&&(s.add(e),l("TTL caching without ttlAutopurge, max, or maxSize can result in unbounded memory consumption.","UnboundedCacheWarning",e,g))}}getRemainingTTL(e){return this.#c.has(e)?1/0:0}#N(){const e=new p(this.#t),t=new p(this.#t);this.#w=e,this.#v=t,this.#P=(n,i,o=r.now())=>{if(t[n]=0!==i?o:0,e[n]=i,0!==i&&this.ttlAutopurge){const e=setTimeout((()=>{this.#I(n)&&this.#R(this.#u[n],"expire")}),i+1);e.unref&&e.unref()}},this.#$=n=>{t[n]=0!==e[n]?r.now():0},this.#O=(o,r)=>{if(e[r]){const s=e[r],a=t[r];if(!s||!a)return;o.ttl=s,o.start=a,o.now=n||i();const l=o.now-a;o.remainingTTL=s-l}};let n=0;const i=()=>{const e=r.now();if(this.ttlResolution>0){n=e;const t=setTimeout((()=>n=0),this.ttlResolution);t.unref&&t.unref()}return e};this.getRemainingTTL=o=>{const r=this.#c.get(o);if(void 0===r)return 0;const s=e[r],a=t[r];return s&&a?s-((n||i())-a):1/0},this.#I=o=>{const r=t[o],s=e[o];return!!s&&!!r&&(n||i())-r>s}}#$=()=>{};#O=()=>{};#P=()=>{};#I=()=>!1;#L(){const e=new p(this.#t);this.#l=0,this.#b=e,this.#k=t=>{this.#l-=e[t],e[t]=0},this.#H=(e,t,n,i)=>{if(this.#x(t))return 0;if(!h(n)){if(!i)throw new TypeError("invalid size value (must be positive integer). When maxSize or maxEntrySize is used, sizeCalculation or size must be set.");if("function"!=typeof i)throw new TypeError("sizeCalculation must be a function");if(n=i(t,e),!h(n))throw new TypeError("sizeCalculation return invalid (expect positive integer)")}return n},this.#F=(t,n,i)=>{if(e[t]=n,this.#n){const n=this.#n-e[t];for(;this.#l>n;)this.#G(!0)}this.#l+=e[t],i&&(i.entrySize=n,i.totalCalculatedSize=this.#l)}}#k=e=>{};#F=(e,t,n)=>{};#H=(e,t,n,i)=>{if(n||i)throw new TypeError("cannot set size without setting maxSize or maxEntrySize on cache");return 0};*#T({allowStale:e=this.allowStale}={}){if(this.#a)for(let t=this.#g;this.#B(t)&&(!e&&this.#I(t)||(yield t),t!==this.#m);)t=this.#p[t]}*#_({allowStale:e=this.allowStale}={}){if(this.#a)for(let t=this.#m;this.#B(t)&&(!e&&this.#I(t)||(yield t),t!==this.#g);)t=this.#d[t]}#B(e){return void 0!==e&&this.#c.get(this.#u[e])===e}*entries(){for(const e of this.#T())void 0===this.#h[e]||void 0===this.#u[e]||this.#x(this.#h[e])||(yield[this.#u[e],this.#h[e]])}*rentries(){for(const e of this.#_())void 0===this.#h[e]||void 0===this.#u[e]||this.#x(this.#h[e])||(yield[this.#u[e],this.#h[e]])}*keys(){for(const e of this.#T()){const t=this.#u[e];void 0===t||this.#x(this.#h[e])||(yield t)}}*rkeys(){for(const e of this.#_()){const t=this.#u[e];void 0===t||this.#x(this.#h[e])||(yield t)}}*values(){for(const e of this.#T())void 0===this.#h[e]||this.#x(this.#h[e])||(yield this.#h[e])}*rvalues(){for(const e of this.#_())void 0===this.#h[e]||this.#x(this.#h[e])||(yield this.#h[e])}[Symbol.iterator](){return this.entries()}[Symbol.toStringTag]="LRUCache";find(e,t={}){for(const n of this.#T()){const i=this.#h[n],o=this.#x(i)?i.__staleWhileFetching:i;if(void 0!==o&&e(o,this.#u[n],this))return this.get(this.#u[n],t)}}forEach(e,t=this){for(const n of this.#T()){const i=this.#h[n],o=this.#x(i)?i.__staleWhileFetching:i;void 0!==o&&e.call(t,o,this.#u[n],this)}}rforEach(e,t=this){for(const n of this.#_()){const i=this.#h[n],o=this.#x(i)?i.__staleWhileFetching:i;void 0!==o&&e.call(t,o,this.#u[n],this)}}purgeStale(){let e=!1;for(const t of this.#_({allowStale:!0}))this.#I(t)&&(this.#R(this.#u[t],"expire"),e=!0);return e}info(e){const t=this.#c.get(e);if(void 0===t)return;const n=this.#h[t],i=this.#x(n)?n.__staleWhileFetching:n;if(void 0===i)return;const o={value:i};if(this.#w&&this.#v){const e=this.#w[t],n=this.#v[t];if(e&&n){const t=e-(r.now()-n);o.ttl=t,o.start=Date.now()}}return this.#b&&(o.size=this.#b[t]),o}dump(){const e=[];for(const t of this.#T({allowStale:!0})){const n=this.#u[t],i=this.#h[t],o=this.#x(i)?i.__staleWhileFetching:i;if(void 0===o||void 0===n)continue;const s={value:o};if(this.#w&&this.#v){s.ttl=this.#w[t];const e=r.now()-this.#v[t];s.start=Math.floor(Date.now()-e)}this.#b&&(s.size=this.#b[t]),e.unshift([n,s])}return e}load(e){this.clear();for(const[t,n]of e){if(n.start){const e=Date.now()-n.start;n.start=r.now()-e}this.set(t,n.value,n)}}set(e,t,n={}){if(void 0===t)return this.delete(e),this;const{ttl:i=this.ttl,start:o,noDisposeOnSet:r=this.noDisposeOnSet,sizeCalculation:s=this.sizeCalculation,status:a}=n;let{noUpdateTTL:l=this.noUpdateTTL}=n;const c=this.#H(e,t,n.size||0,s);if(this.maxEntrySize&&c>this.maxEntrySize)return a&&(a.set="miss",a.maxEntrySizeExceeded=!0),this.#R(e,"set"),this;let u=0===this.#a?void 0:this.#c.get(e);if(void 0===u)u=0===this.#a?this.#g:0!==this.#f.length?this.#f.pop():this.#a===this.#t?this.#G(!1):this.#a,this.#u[u]=e,this.#h[u]=t,this.#c.set(e,u),this.#d[this.#g]=u,this.#p[u]=this.#g,this.#g=u,this.#a++,this.#F(u,c,a),a&&(a.set="add"),l=!1;else{this.#E(u);const n=this.#h[u];if(t!==n){if(this.#S&&this.#x(n)){n.__abortController.abort(new Error("replaced"));const{__staleWhileFetching:t}=n;void 0===t||r||(this.#C&&this.#i?.(t,e,"set"),this.#A&&this.#y?.push([t,e,"set"]))}else r||(this.#C&&this.#i?.(n,e,"set"),this.#A&&this.#y?.push([n,e,"set"]));if(this.#k(u),this.#F(u,c,a),this.#h[u]=t,a){a.set="replace";const e=n&&this.#x(n)?n.__staleWhileFetching:n;void 0!==e&&(a.oldValue=e)}}else a&&(a.set="update")}if(0===i||this.#w||this.#N(),this.#w&&(l||this.#P(u,i,o),a&&this.#O(a,u)),!r&&this.#A&&this.#y){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}return this}pop(){try{for(;this.#a;){const e=this.#h[this.#m];if(this.#G(!0),this.#x(e)){if(e.__staleWhileFetching)return e.__staleWhileFetching}else if(void 0!==e)return e}}finally{if(this.#A&&this.#y){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}}}#G(e){const t=this.#m,n=this.#u[t],i=this.#h[t];return this.#S&&this.#x(i)?i.__abortController.abort(new Error("evicted")):(this.#C||this.#A)&&(this.#C&&this.#i?.(i,n,"evict"),this.#A&&this.#y?.push([i,n,"evict"])),this.#k(t),e&&(this.#u[t]=void 0,this.#h[t]=void 0,this.#f.push(t)),1===this.#a?(this.#m=this.#g=0,this.#f.length=0):this.#m=this.#d[t],this.#c.delete(n),this.#a--,t}has(e,t={}){const{updateAgeOnHas:n=this.updateAgeOnHas,status:i}=t,o=this.#c.get(e);if(void 0!==o){const e=this.#h[o];if(this.#x(e)&&void 0===e.__staleWhileFetching)return!1;if(!this.#I(o))return n&&this.#$(o),i&&(i.has="hit",this.#O(i,o)),!0;i&&(i.has="stale",this.#O(i,o))}else i&&(i.has="miss");return!1}peek(e,t={}){const{allowStale:n=this.allowStale}=t,i=this.#c.get(e);if(void 0===i||!n&&this.#I(i))return;const o=this.#h[i];return this.#x(o)?o.__staleWhileFetching:o}#M(e,t,n,i){const o=void 0===t?void 0:this.#h[t];if(this.#x(o))return o;const r=new c,{signal:s}=n;s?.addEventListener("abort",(()=>r.abort(s.reason)),{signal:r.signal});const a={signal:r.signal,options:n,context:i},l=(i,o=!1)=>{const{aborted:s}=r.signal,l=n.ignoreFetchAbort&&void 0!==i;if(n.status&&(s&&!o?(n.status.fetchAborted=!0,n.status.fetchError=r.signal.reason,l&&(n.status.fetchAbortIgnored=!0)):n.status.fetchResolved=!0),s&&!l&&!o)return u(r.signal.reason);const c=h;return this.#h[t]===h&&(void 0===i?c.__staleWhileFetching?this.#h[t]=c.__staleWhileFetching:this.#R(e,"fetch"):(n.status&&(n.status.fetchUpdated=!0),this.set(e,i,a.options))),i},u=i=>{const{aborted:o}=r.signal,s=o&&n.allowStaleOnFetchAbort,a=s||n.allowStaleOnFetchRejection,l=a||n.noDeleteOnFetchRejection,c=h;if(this.#h[t]===h&&(l&&void 0!==c.__staleWhileFetching?s||(this.#h[t]=c.__staleWhileFetching):this.#R(e,"fetch")),a)return n.status&&void 0!==c.__staleWhileFetching&&(n.status.returnedStale=!0),c.__staleWhileFetching;if(c.__returned===c)throw i};n.status&&(n.status.fetchDispatched=!0);const h=new Promise(((t,i)=>{const s=this.#r?.(e,o,a);s&&s instanceof Promise&&s.then((e=>t(void 0===e?void 0:e)),i),r.signal.addEventListener("abort",(()=>{n.ignoreFetchAbort&&!n.allowStaleOnFetchAbort||(t(void 0),n.allowStaleOnFetchAbort&&(t=e=>l(e,!0)))}))})).then(l,(e=>(n.status&&(n.status.fetchRejected=!0,n.status.fetchError=e),u(e)))),d=Object.assign(h,{__abortController:r,__staleWhileFetching:o,__returned:void 0});return void 0===t?(this.set(e,d,{...a.options,status:void 0}),t=this.#c.get(e)):this.#h[t]=d,d}#x(e){if(!this.#S)return!1;const t=e;return!!t&&t instanceof Promise&&t.hasOwnProperty("__staleWhileFetching")&&t.__abortController instanceof c}async fetch(e,t={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:o=this.noDeleteOnStaleGet,ttl:r=this.ttl,noDisposeOnSet:s=this.noDisposeOnSet,size:a=0,sizeCalculation:l=this.sizeCalculation,noUpdateTTL:c=this.noUpdateTTL,noDeleteOnFetchRejection:u=this.noDeleteOnFetchRejection,allowStaleOnFetchRejection:h=this.allowStaleOnFetchRejection,ignoreFetchAbort:d=this.ignoreFetchAbort,allowStaleOnFetchAbort:p=this.allowStaleOnFetchAbort,context:m,forceRefresh:g=!1,status:f,signal:y}=t;if(!this.#S)return f&&(f.fetch="get"),this.get(e,{allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:o,status:f});const b={allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:o,ttl:r,noDisposeOnSet:s,size:a,sizeCalculation:l,noUpdateTTL:c,noDeleteOnFetchRejection:u,allowStaleOnFetchRejection:h,allowStaleOnFetchAbort:p,ignoreFetchAbort:d,status:f,signal:y};let v=this.#c.get(e);if(void 0===v){f&&(f.fetch="miss");const t=this.#M(e,v,b,m);return t.__returned=t}{const t=this.#h[v];if(this.#x(t)){const e=n&&void 0!==t.__staleWhileFetching;return f&&(f.fetch="inflight",e&&(f.returnedStale=!0)),e?t.__staleWhileFetching:t.__returned=t}const o=this.#I(v);if(!g&&!o)return f&&(f.fetch="hit"),this.#E(v),i&&this.#$(v),f&&this.#O(f,v),t;const r=this.#M(e,v,b,m),s=void 0!==r.__staleWhileFetching&&n;return f&&(f.fetch=o?"stale":"refresh",s&&o&&(f.returnedStale=!0)),s?r.__staleWhileFetching:r.__returned=r}}async forceFetch(e,t={}){const n=await this.fetch(e,t);if(void 0===n)throw new Error("fetch() returned undefined");return n}memo(e,t={}){const n=this.#s;if(!n)throw new Error("no memoMethod provided to constructor");const{context:i,forceRefresh:o,...r}=t,s=this.get(e,r);if(!o&&void 0!==s)return s;const a=n(e,s,{options:r,context:i});return this.set(e,a,r),a}get(e,t={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:o=this.noDeleteOnStaleGet,status:r}=t,s=this.#c.get(e);if(void 0!==s){const t=this.#h[s],a=this.#x(t);return r&&this.#O(r,s),this.#I(s)?(r&&(r.get="stale"),a?(r&&n&&void 0!==t.__staleWhileFetching&&(r.returnedStale=!0),n?t.__staleWhileFetching:void 0):(o||this.#R(e,"expire"),r&&n&&(r.returnedStale=!0),n?t:void 0)):(r&&(r.get="hit"),a?t.__staleWhileFetching:(this.#E(s),i&&this.#$(s),t))}r&&(r.get="miss")}#D(e,t){this.#p[t]=e,this.#d[e]=t}#E(e){e!==this.#g&&(e===this.#m?this.#m=this.#d[e]:this.#D(this.#p[e],this.#d[e]),this.#D(this.#g,e),this.#g=e)}delete(e){return this.#R(e,"delete")}#R(e,t){let n=!1;if(0!==this.#a){const i=this.#c.get(e);if(void 0!==i)if(n=!0,1===this.#a)this.#V(t);else{this.#k(i);const n=this.#h[i];if(this.#x(n)?n.__abortController.abort(new Error("deleted")):(this.#C||this.#A)&&(this.#C&&this.#i?.(n,e,t),this.#A&&this.#y?.push([n,e,t])),this.#c.delete(e),this.#u[i]=void 0,this.#h[i]=void 0,i===this.#g)this.#g=this.#p[i];else if(i===this.#m)this.#m=this.#d[i];else{const e=this.#p[i];this.#d[e]=this.#d[i];const t=this.#d[i];this.#p[t]=this.#p[i]}this.#a--,this.#f.push(i)}}if(this.#A&&this.#y?.length){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}return n}clear(){return this.#V("delete")}#V(e){for(const t of this.#_({allowStale:!0})){const n=this.#h[t];if(this.#x(n))n.__abortController.abort(new Error("deleted"));else{const i=this.#u[t];this.#C&&this.#i?.(n,i,e),this.#A&&this.#y?.push([n,i,e])}}if(this.#c.clear(),this.#h.fill(void 0),this.#u.fill(void 0),this.#w&&this.#v&&(this.#w.fill(0),this.#v.fill(0)),this.#b&&this.#b.fill(0),this.#m=0,this.#g=0,this.#f.length=0,this.#l=0,this.#a=0,this.#A&&this.#y){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}}}function f(e){window.$monomerHover=e}var y=n(2003),b=n(6077),v=n(3561),w=n(9235);const C="MonomerHoverLinks";async function S(e,t,n,i,r,s=!1){const a=i.getSeqHandler(e),l=a.alphabet==y.YI.RNA||a.alphabet==y.YI.DNA,c=a.isHelm()&&l,u=!a.isHelm()&&l,h=e=>null==e?null:c?s?e:Math.floor(e/3):u&&s?3*e+1:e,d=s?await i.getHelmToMolfileConverter(n):null,p=new g({max:100});function m(e,t){const a=e.get(t);if(null==a)return null;let l=p.get(a);return l||p.set(a,l=function(e,t){const a=i.getSeqHandler(e);if(s){const e=a.getHelm(t);return i.helmToAtomicLevelSingle(e,d,!1,!1).monomers}{const e=a.getSplitted(t),i=a.defaultBiotype,s=o().count(0).take(e.length).map((t=>({position:t,symbol:e.getCanonical(t),biotype:i}))).toArray(),l=a.alphabet,c=l==y.YI.RNA||l==y.YI.DNA?"RNA":"PEPTIDE",u=(0,b.eM)([s],c,l,n,r);return(0,v.gU)(s,u,l,c).monomers}}(e,t)),l}const S={targetCol:t,handler:(t,i,o)=>{const r=o.grid,s=t.tableRowIndex,a=t.gridRow,l=r.cell(o.name,a),c=null!==(u=window.$monomerHover)&&void 0!==u?u:null;var u;if(!c||c&&(c.dataFrameId!=e.dataFrame.id||c.gridRowIdx!=a||c.seqColName!=e.name||c.seqPosition!=i?.position)){if(c&&(f(null),c.gridCell.render()),!i)return f(null),!0;f({gridCell:l,dataFrameId:e.dataFrame.id,gridRowIdx:a,seqColName:e.name,seqPosition:h(i?.position)??-1,getSubstruct:()=>{if(!i||"*"===i.symbol)return;const t=m(e,s);if(!t)return;const o=t.get(h(i?.position));return o?(0,w.H)([o],n):{atoms:[],bonds:[],highlightAtomColors:[],highlightBondColors:[]}}}),l.render()}return!0},getSubstruct:i=>{if("true"!=t.getTag(".sequence-src-highlight-monomers"))return;if(null==i)return;if(!e.get(i))return;const o=m(e,i);return o?(0,w.H)(o.values(),n):void 0}};return function(e,t){let n=e[C];n||(n=e[C]=[]),n.push(t),e[C]=n}(e.temp,S),function(e,t){let n=e["substruct-providers"];n||(n=e["substruct-providers"]=[]),n.push(t),e["substruct-providers"]=n}(t.temp,S),S}function A(e,t){try{const n=e.tableColumn;if(!n)return;const i=function(e){return e.temp[C]??[]}(n);for(let n=i.length-1;n>=0;--n){const o=i[n],r=e.grid.col(o.targetCol.name);if(r&&!o.handler(e,t,r))break}}catch(e){console.error(e)}}},6718:(e,t,n)=>{"use strict";n.d(t,{A7:()=>p,pj:()=>u,uL:()=>h,uX:()=>c});var i=n(6082),o=n(4328),r=n(6295),s=n(3151),a=n(3077),l=n(439);function c(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(s.Ec).forEach((t=>{if("symbol"===t){const o=e.get(s.Ec[t],n);i[t]="."===o?e.get(s.yw,n):o}else if("rgroups"===t){const o=e.get(s.Ec[t],n).split("\n"),r=[];o.forEach((e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)})),i[t]=r}else s.Ec[t]&&(i[t]=e.get(s.Ec[t],n))})),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}async function u(){const e=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===e.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await e[0].prepare().call()).getOutputParamValue()}async function h(e,t,n){e instanceof i.Column&&(e=(0,a.R)(e,n).columns.toList());const r=(await u()).getMonomerLib(),s=new Array(e.length),c=e[0].length,h=new Float32Array(c);for(let n=0;n<e.length;++n){const a=n<t.length?t.getCanonical(n):l._S,u=r.getMonomer("PEPTIDE",a)?.smiles??"",d=e[n],p=d.getRawData(),m=d.categories,g=m.indexOf("");if(s[n]={categories:m,data:p,emptyIndex:g},void 0===a)continue;const f=i.Column.fromStrings("smiles",m.map((e=>r.getMonomer("PEPTIDE",e)?.smiles??""))),y=(i.DataFrame.fromColumns([f]),await o.chem.getSimilarities(f,u)),b=y?y.getRawData():null;for(let e=0;e<c;++e){const t=p[e];a!==l._S&&t!==g?h[e]+=b[t]:a===l._S&&t===g&&(h[e]+=1)}}for(let n=0;n<h.length;++n){let o=h[n]/t.length;for(let r=0;r<e.length;++r){const e=s[r];if(r>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&r<t.length){o=i.FLOAT_NULL;break}}h[n]=o}return i.Column.fromFloat32Array("Similarity",h)}async function d(e){const t=(await u()).getMonomerLib(),n=[],r={},s=e.map((e=>t.getMonomer("PEPTIDE",e)?.smiles??"")),a=i.Column.fromStrings("smiles",s);for(let t=0;t<s.length;++t){r[e[t]]=t;const i=s[t],l=""===i?new Array(s.length).fill(0):(await o.chem.getSimilarities(a,i)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:r}}async function p(e,t="Morgan"){const n=(await u()).getMonomerLib(),o=new Array(e.length).fill(0).map((()=>new Array(e.length).fill(0))),s={},a=e.map((e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||"")),l=i.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(e);const c=i.Column.fromStrings("smiles",a),h=(i.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:t}))?.entries);if(!h)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n      falling back to Morgan fingerprints`),await d(e);for(let t=0;t<h.length;++t)if(o[t][t]=1,s[e[t]]=t,h[t])for(let e=t+1;e<h.length;++e)h[e]&&(o[t][e]=o[e][t]=(0,r.$1)(h[t],h[e]));return{scoringMatrix:o,alphabetIndexes:s}}},6197:(e,t,n)=>{"use strict";n.d(t,{Y:()=>o});var i=n(3599);function o(e){let t;switch(e){case i.o.BASE:case i.o.SUGAR:case i.o.LINKER:case i.o.NUCLEOTIDE:case"nucleotide":t="RNA";break;case i.o.AA:t="PEPTIDE";break;case i.o.CHEM:t="CHEM";break;case i.o.BLOB:t="BLOB";break;default:t="PEPTIDE",console.warn(`Unexpected HelmType '${e}'`)}return t}},9235:(e,t,n)=>{"use strict";n.d(t,{H:()=>c,R:()=>l});var i=n(6082),o=n(1991),r=n.n(o),s=n(330),a=n(3599);async function l(e,t,o,l,c,u,h){const d=e.length,p=e.dataFrame,m=Math.max(navigator.hardwareConcurrency-2,1),g=new Array(m).fill(null).map((()=>new Worker(new URL(n.p+n.u(455),n.b)))),f=d/m,y=new Array(m),b=u.getSeqHandler(e),v="RNA"==l?a.o.NUCLEOTIDE:a.o.AA,w=r().count(0).take(e.length).map((e=>{const t=b.getSplitted(e);return r().count(0).take(t.length).map((e=>({position:e,symbol:t.getCanonical(e),biotype:v}))).toArray()})).toArray();for(let e=0;e<m;e++){const n=g[e],i=Math.floor(e*f),r=e===m-1?d:Math.floor((e+1)*f);y[e]=new Promise((e=>{n.onmessage=t=>{e(t.data)}})),n.postMessage({seqList:w,monomersDict:t,alphabet:o,polymerType:l,start:i,end:r})}const C=[],S=[];await Promise.all(y).then((e=>{for(const t of e)C.push(...t.molfiles),S.push(...t.warnings)})),setTimeout((()=>{g.forEach((e=>{e.terminate()}))}),0);const A=(0,s.qj)(p,e.name),x=i.Column.fromType(i.COLUMN_TYPE.STRING,A,e.length).init((e=>C[e]?.molfile));return x.semType=i.SEMTYPE.MOLECULE,x.meta.units=i.UNITS.Molecule.MOLBLOCK,x.setTag(".sequence-src-col",e.name),{molCol:x,warnings:S}}function c(e,t){const n={},o={};for(const r of e){const e=t.getWebEditorMonomer(r.biotype,r.symbol).backgroundcolor,a=(0,s.vG)(e??i.Color.toRgb(i.Color.mouseOverRows))??[1,0,0,.7];for(const e of r.atoms)n[e]=a;for(const e of r.bonds)o[e]=a}return{atoms:Object.keys(n).map((e=>parseInt(e))),bonds:Object.keys(o).map((e=>parseInt(e))),highlightAtomColors:n,highlightBondColors:o}}},3561:(e,t,n)=>{"use strict";n.d(t,{Hb:()=>l,YN:()=>g,gU:()=>c});var i=n(8123),o=n(294),r=n(3151),s=n(439),a=n(6197);function l(e,t,n){const o=new Map;for(const a of e.getMonomerSymbolsByType(t)){const l=e.getMonomer(t,a);if("RNA"===t&&("Branch"===l.monomerType||n===s.YI.DNA&&l.symbol===i.u.DEOXYRIBOSE.symbol||n===s.YI.RNA&&l.symbol===i.u.RIBOSE.symbol||l.symbol===i.u.PHOSPHATE.symbol)||"PEPTIDE"===t&&"Branch"!==l.monomerType){const e={};r.f6.forEach((t=>{e[t]=l[t]})),o.set(l.symbol,e)}}return o}function c(e,t,n,r){if(0===e.length)return o.vF.createEmpty();const l=m,{atomCount:c,bondCount:h,needsCapping:p}=l(e,t,n,r),f=new Array(c),y=new Array(h);let b,v=null,w=null;"PEPTIDE"===r?b=u:(b=d,v=n===s.YI.DNA?(0,o.xb)(t,i.u.DEOXYRIBOSE):(0,o.xb)(t,i.u.RIBOSE),w=(0,o.xb)(t,i.u.PHOSPHATE));const C={i:0,nodeShift:0,bondShift:0,backbonePositionShift:new Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},S={sugar:v,phosphate:w,seqLength:e.length,atomCount:c,bondCount:h},A=new o.Cg,x=[];let M,E=0;for(C.i=0;C.i<S.seqLength;++C.i){const n=e[C.i];if(n.symbol===s._S)continue;const i=(0,o.xb)(t,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)});M=i.terminalR2Atom;const r=C.nodeShift,l=C.bondShift;b(i,f,y,C,S),i.stereoAtoms?.forEach((e=>x.push(e+E))),E+=i.atoms.x.length;const c=C.nodeShift-r,u=new Array(c);for(let e=0;e<c;++e)u[e]=r+e;const h=C.bondShift-l,d=new Array(h);for(let e=0;e<h;++e)d[e]=l+e;A.set(C.i,{biotype:n.biotype,symbol:n.symbol,atoms:u,bonds:d})}p&&function(e,t,n,o,r=i.u.OXYGEN){const s=n.nodeShift+1;e[o.atomCount]=i.u.V3K_BEGIN_DATA_LINE+s+" "+(r??i.u.OXYGEN)+" "+g(n.backbonePositionShift[0])+" "+n.flipFactor*g(n.backbonePositionShift[1])+" 0.000000 0\n";const a=n.backboneAttachNode,l=s;t[o.bondCount]=i.u.V3K_BEGIN_DATA_LINE+n.bondShift+" 1 "+a+" "+l+"\n"}(f,y,C,S,M??i.u.OXYGEN);const T=i.u.V3K_BEGIN_COUNTS_LINE+c+" "+h+i.u.V3K_COUNTS_LINE_ENDING;let _="";return _+=i.u.V3K_HEADER_FIRST_LINE,_+=i.u.V3K_HEADER_SECOND_LINE,_+=i.u.V3K_BEGIN_CTAB_BLOCK,_+=T,_+=i.u.V3K_BEGIN_ATOM_BLOCK,_+=f.join(""),_+=i.u.V3K_END_ATOM_BLOCK,_+=i.u.V3K_BEGIN_BOND_BLOCK,_+=y.join(""),_+=i.u.V3K_END_BOND_BLOCK,x.length>0&&(_+=function(e){const t=[];let n=`M  V30 MDLV30/STEABS ATOMS=(${e.length}`;for(let i=0;i<e.length;i++){const o=`${n} ${e[i]}`;o.length>76?(t.push(`${n} -\n`),n=`M  V30 ${e[i]}`):n=o,i===e.length-1&&t.push(`${n})\n`)}return`M  V30 BEGIN COLLECTION\n${t.join("")}M  V30 END COLLECTION\n`}(x)),_+=i.u.V3K_END_CTAB_BLOCK,_+=i.u.V3K_END,{molfile:_,monomers:A}}function u(e,t,n,i){i.flipFactor=(-1)**(i.i%2),h(e,t,n,i)}function h(e,t,n,o){!function(e,t,n){for(let o=0;o<e.atoms.atomTypes.length;++o){const r=n.nodeShift+o+1;t[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+e.atoms.atomTypes[o]+" "+g(n.backbonePositionShift[0]+e.atoms.x[o])+" "+g(n.backbonePositionShift[1]+n.flipFactor*e.atoms.y[o])+" "+e.atoms.kwargs[o]}}(e,t,o),p(e,n,o),function(e,t,n){if(0!==n.backboneAttachNode){const o=n.bondShift,r=n.backboneAttachNode,s=e.meta.terminalNodes[0]+n.nodeShift;t[n.bondShift-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+r+" "+s+"\n"}}(e,n,o),null!==e.meta.branchShift&&e.meta.terminalNodes.length>2&&function(e,t){t.branchAttachNode=t.nodeShift+e.meta.terminalNodes[2];for(let n=0;n<2;++n)t.branchPositionShift[n]=t.backbonePositionShift[n]+e.meta.branchShift[n]}(e,o),function(e,t){t.backboneAttachNode=t.nodeShift+e.meta.terminalNodes[1],t.bondShift+=e.bonds.atomPairs.length+1,t.nodeShift+=e.atoms.atomTypes.length,t.backbonePositionShift[0]+=e.meta.backboneShift?.[0]??0,t.backbonePositionShift[1]+=t.flipFactor*(e.meta.backboneShift?.[1]??0)}(e,o)}function d(e,t,n,o,r){if(0===o.i)h(r.sugar,t,n,o);else for(const e of[r.phosphate,r.sugar])h(e,t,n,o);!function(e,t,n,o){(function(e,t,n){for(let o=0;o<e.atoms.atomTypes.length;++o){const r=n.nodeShift+o+1;t[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+e.atoms.atomTypes[o]+" "+g(n.branchPositionShift[0]+e.atoms.x[o])+" "+g(n.branchPositionShift[1]+n.flipFactor*e.atoms.y[o])+" "+e.atoms.kwargs[o]}})(e,t,o),p(e,n,o),function(e,t,n){const o=n.bondShift,r=n.branchAttachNode,s=e.meta.terminalNodes[0]+n.nodeShift;t[o-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+r+" "+s+"\n"}(e,n,o);const r=o.bondShift,s=o.branchAttachNode,a=e.meta.terminalNodes[0]+o.nodeShift;n[r-1]=i.u.V3K_BEGIN_DATA_LINE+r+" 1 "+s+" "+a+"\n",o.bondShift+=e.bonds.atomPairs.length+1,o.nodeShift+=e.atoms.atomTypes.length}(e,t,n,o)}function p(e,t,n){for(let o=0;o<e.bonds.atomPairs.length;++o){const r=n.bondShift+o+1,s=e.bonds.atomPairs[o][0]+n.nodeShift,a=e.bonds.atomPairs[o][1]+n.nodeShift;let l="";if(e.bonds.bondConfiguration.has(o)){let t=e.bonds.bondConfiguration.get(o);n.flipFactor<0&&(t=1===t?3:1),l=" CFG="+t}const c=e.bonds.kwargs.has(o)?" "+e.bonds.kwargs.get(o):"";t[n.bondShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+e.bonds.bondTypes[o]+" "+s+" "+a+l+c+"\n"}}function m(e,t,n,r){let l=0,c=0,u=0,h=!0,d=null;for(const n of e)if(n.symbol!==s._S){if("*"==n.symbol)throw new Error("Gap canonical symbol is '', not '*");d=(0,o.xb)(t,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),l+=d.atoms.x.length,c+=d.bonds.bondTypes.length,u++}if("PEPTIDE"===r)l+=1,c+=u,u>0&&((d?.meta?.rNodes?.length??0)<2||d?.terminalR2Atom?.toLowerCase()===i.u.HYDROGEN.toLowerCase())&&(h=!1,l-=1,c-=1);else{const r=n===s.YI.DNA?(0,o.xb)(t,i.u.DEOXYRIBOSE):(0,o.xb)(t,i.u.RIBOSE),a=(0,o.xb)(t,i.u.PHOSPHATE);l+=(e.length-1)*a.atoms.x.length,l+=e.length*r.atoms.x.length,l+=1,c+=(e.length-1)*a.bonds.bondTypes.length,c+=e.length*r.bonds.bondTypes.length,c-=1,c+=3*e.length}return{atomCount:l,bondCount:c,needsCapping:h}}function g(e){return Math.round(i.u.PRECISION_FACTOR*e)/i.u.PRECISION_FACTOR}},6077:(e,t,n)=>{"use strict";n.d(t,{C4:()=>m,eM:()=>g});var i=n(4328),o=n(6082),r=n(1991),s=n.n(r),a=n(439),l=n(3561),c=n(9235),u=n(294),h=n(9192),d=n(330),p=n(8123);async function m(e,t,n,r,l){if(t.semType!==o.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${o.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let u=t;const p=r.getSeqHandler(t);let m,f;p.notation!==a.Hi.SEPARATOR&&(u=p.convert(a.Hi.SEPARATOR,"."),u.name=t.name);try{f=r.getSeqHandler(u).alphabet,m=(0,d.pz)(f)}catch(e){const[t,n]=(0,h.AP)(e);return{molCol:null,warnings:[t]}}const y=function(e,t){const n=e.length,o=new Array(n),r=t.getSeqHandler(e);let a=!1;const l=r.defaultBiotype;for(let e=0;e<n;++e){const t=r.getSplitted(e);a||(a=0===t.length),o[e]=s().count(0).take(t.length).filter((e=>!t.isGap(e))).map((e=>({position:e,biotype:l,symbol:t.getCanonical(e)}))).toArray()}return a&&i.shell.warning(`Some values in the "${e.name}" column are empty`),o}(u,r),b=g(y,m,f,n,l),v=u.length,w=await(0,c.R)(u,b,f,m,n,r,l);w.warnings.length>.05*v&&i.shell.warning(`Molfile conversion resulted in ${w.warnings.length} errors`);const C=o.Func.find({name:"convertToV3KViaOCL"})[0];if(C&&w.molCol)try{const e=w.molCol.toList(),t=await C.apply({mols:e});w.molCol.init((n=>t[n]?t[n]:e[n]))}catch(e){console.error(e)}return w}function g(e,t,n,i,o){const r=(0,l.Hb)(i,t,n),s={},c={value:null};if("RNA"===t){const e=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of e)f(s,n.symbol,r,o,t,c)}for(let n=0;n<e.length;++n){const i=e[n];for(const e of i){const n=e.symbol;if(""!==n)try{if("RNA"===t&&3===n.split(/\(|\)/).filter((e=>!!e)).length){const e=n.split(/\(|\)/)[1];f(s,e,r,o,t,c),s[t]?.[e]&&(s[t][n]=s[t][e])}else f(s,n,r,o,t,c)}catch(e){const t=e instanceof Error?e.message:e.toString(),i=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${t}\n${i}`),new Error(`Can't get monomer '${n}' from library: ${t}`)}}}return s}function f(e,t,n,i,o,r){const s={polymerType:o,symbol:t};if(!(0,u.bq)(e,s)){const a=function(e,t,n,i,o){if(t.has(e)){const s=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,"").replace("OH","O").replace("Oh","O"),t.push(e)}return t}(s.rgroups),c=(r=s.molfile).includes("V3000")?function(e){const t=new Map,n=/M  V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(e));)i.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(i[1]),parseInt(i[3]));return t}(r):function(e){const t=new Map;let n=e.indexOf(p.u.V2K_A_LINE,0),i=n;for(;-1!==n;){i=e.indexOf("\n",n);const o=parseInt(e.substring(n,i).replace(/^A\s+/,""));n=e.indexOf("R",i),i=e.indexOf("\n",n);const r=parseInt(e.substring(n,i).replace(/^R/,""));t.set(o,r),n=e.indexOf(p.u.V2K_A_LINE,i)}for(n=e.indexOf(p.u.V2K_RGP_LINE,0),i=e.indexOf("\n",n);-1!==n;){n+=p.u.V2K_RGP_SHIFT,i=e.indexOf("\n",n);const o=e.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<o.length;e+=2){if(t.has(o[e])&&t.get(o[e])!==o[e+1])throw new Error(`r-group index ${o[e]} has already been added with a different value`);t.set(o[e],o[e+1])}n=e.indexOf(p.u.V2K_RGP_LINE,i)}return t}(r),u=s.molfile.includes("V3000")?s.molfile:function(e,t){const n=t.get_mol(function(e){return e.split("\n").map((e=>{const t=e.indexOf(" R#  "),n=e.indexOf(" R   ");if(-1===t&&-1===n)return e;const i=-1!==t?t:n,o=e.split("");for(let e=i+5;e<o.length;e++)" "!==o[e]&&(o[e]="0");return o.join("")})).join("\n")}(e)),i=n.get_v3Kmolblock();return n.delete(),i}(function(e){let t=e.indexOf(p.u.V2K_A_LINE,0);-1===t&&(t=e.indexOf(p.u.V2K_RGP_LINE));const n=e.indexOf(p.u.V3K_END,t);return e.substring(0,t)+e.substring(n)}(s.molfile),n),h=function(e){let t=(e=e.replaceAll("\r","")).indexOf(p.u.V3K_BEGIN_COUNTS_LINE)+p.u.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const i=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:i,bondCount:parseInt(e.substring(t,n))}}(u),d=function(e,t){const n=new Array(t),i=new Float32Array(t),o=new Float32Array(t),r=new Array(t);let s=e.indexOf(p.u.V3K_BEGIN_ATOM_BLOCK);s=e.indexOf("\n",s);let a=s;for(let l=0;l<t;l++){s=e.indexOf(p.u.V3K_BEGIN_DATA_LINE,s)+p.u.V3K_IDX_SHIFT,a=e.indexOf(" ",s),s=a+1,a=e.indexOf(" ",s),n[l]=e.substring(s,a);const t=new Array(2);for(let n=0;n<2;++n)s=a+1,a=e.indexOf(" ",s),t[n]=parseFloat(e.substring(s,a));i[l]=t[0],o[l]=t[1],s=a,a=e.indexOf("\n",s)+1,r[l]=e.slice(s,a),s=a}return{atomTypes:n,x:i,y:o,kwargs:r}}(u,h.atomCount),m=function(e,t){const n=new Uint32Array(t),i=new Array(t),o=new Map,r=new Map;let s=e.indexOf(p.u.V3K_BEGIN_BOND_BLOCK);s=e.indexOf("\n",s);let a=s;for(let l=0;l<t;++l){const t=new Array(3);s=e.indexOf(p.u.V3K_BEGIN_DATA_LINE,a)+p.u.V3K_IDX_SHIFT,a=e.indexOf(" ",s);for(let n=0;n<3;++n)s=a+1,a=Math.min(e.indexOf("\n",s),e.indexOf(" ",s)),t[n]=parseInt(e.slice(s,a));n[l]=t[0],i[l]=t.slice(1);const c=e.indexOf("\n",s);let u=e.slice(a,c),h=u.indexOf(p.u.V3K_BOND_CONFIG);if(-1!==h){h=u.indexOf("=",h)+1;let e=u.indexOf(" ",h);-1===e&&(e=u.length);const t=parseInt(u.slice(h,e));o.set(l,t);const n=p.u.V3K_BOND_CONFIG+t.toString();u=u.replace(n,"")}u||r.set(l,u)}return{bondTypes:n,atomPairs:i,bondConfiguration:o,kwargs:r}}(u,h.bondCount),g=function(e,t,n,i){const o={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};if(n&&i&&[1,2].some((e=>!Array.from(i.values()).find((t=>t==e))))){const o=[1,2].find((e=>!Array.from(i.values()).find((t=>t==e)))),r=[1,2].find((e=>Array.from(i.values()).find((t=>t==e)))),s=Array.from(i.keys()).find((e=>i.get(e)===r))-1,a=e.x[s],l=e.y[s],c=t.atomPairs.find((e=>e.includes(s+1))).find((e=>e!==s+1))-1;let u=e.x.reduce(((t,n,i)=>{if(i===s)return t;if(i===c)return t;const o=e.y[i];return Math.sqrt((n-a)**2+(o-l)**2)>Math.sqrt((e.x[t]-a)**2+(e.y[t]-l)**2)?i:t}),-1);if(-1===u&&(u=e.x.length,e.x=new Float32Array([...e.x,-a]),e.y=new Float32Array([...e.y,-l]),e.atomTypes=[...e.atomTypes,"H"],e.kwargs=[...e.kwargs,""],t.atomPairs.push([c+1,u+1]),t.bondTypes=new Uint32Array([...t.bondTypes,1]),t.kwargs.set(t.atomPairs.length-1,"")),i.set(u+1,o),1===o)n.unshift(e.atomTypes[u]);else{if(2!==o)throw new Error(`Unexpected missing R-group: ${o}`);n.splice(1,0,e.atomTypes[u])}}return function(e,t,n){for(const[i,o]of n)e.atomTypes[i-1]=t[o-1]}(e,n,i),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const i of[1,2])if(e.get(t.rNodes[n])===i){const e=t.rNodes[i-1];t.rNodes[i-1]=t.rNodes[n],t.rNodes[n]=e}}(i,o),y(t,o),o}(d,m,a,c),f=function(e){let t=[],n=e.indexOf("M  V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const i=e.indexOf(")",n);t=t.concat(e.substring(n,i).split(" ").slice(1).map((e=>parseInt(e)))),n=i,n=e.indexOf("M  V30 MDLV30/STEABS ATOMS=(",n)}return t}(u),v={atoms:d,bonds:m,meta:g,stereoAtoms:f};return"PEPTIDE"===i?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,o=e.atoms.y;E(e,-i[t],-o[t]);const r=S(i[n],o[n]);A(e.atoms,-r),i[e.meta.rNodes[1]-1]<0&&x(e);const s=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const i=n[e],o=n[(e+1)%2];t.has(i)?t.get(i)?.push(o):t.set(i,new Array(1).fill(o))}return t}(e);let n=0;const i=e.atoms.atomTypes.length;let o=0;if(e.meta.terminalNodes.length<2)return null;for(;0===n;){const r=t.get(e.meta.terminalNodes[1])[o];if(e.atoms.atomTypes[r-1]===p.u.OXYGEN&&r!==e.meta.rNodes[1]&&(n=r),o++,o>i)return null}return n}(e);null!=s&&(function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){M(e,!0)}(e),A(e.atoms,-function(e,t){return S(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,s),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const i=t-1,o=n-1,r=e.atoms.x,s=e.atoms.y,a=r[i],l=s[i];r[i]=r[o],s[i]=s[o],r[o]=a,s[o]=l}(e,t,e.meta.rNodes[1])}(e,s))}(v):e===p.u.RIBOSE.symbol||e===p.u.DEOXYRIBOSE.symbol?function(e,t){const n=e.atoms.x,i=e.atoms.y;let o=e.meta.terminalNodes[0]-1;const r=e.meta.rNodes[1]-1;E(e,-n[o],-i[o]);const s=S(n[e.meta.rNodes[2]-1],i[e.meta.rNodes[2]-1]);A(e.atoms,-s),n[e.meta.rNodes[0]-1]>n[e.meta.rNodes[1]-1]&&x(e);const a=S(n[r],i[r]);A(e.atoms,3*Math.PI/2-a),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,i=e.meta.rNodes[2]-1,o=e.meta.terminalNodes[2]-1,r=t[i]-t[o],s=n[i]-n[o];return Math.atan2(r,s)}(e),o=e.meta.terminalNodes[0]-1,E(e,-n[o],-i[o])}(v,o):e===p.u.PHOSPHATE.symbol?function(e){const t=e.meta.rNodes[1]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,o=e.atoms.y;E(e,-i[t],-o[t]);const r=S(i[n],o[n]);A(e.atoms,Math.PI/2-r)}(v):function(e,t){const n=e.atoms.x,i=e.atoms.y,o=e.meta.terminalNodes[0]-1,r=e.meta.rNodes[0]-1;E(e,-n[o],-i[o]);const s=S(n[r],i[r]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");A(e.atoms,Math.PI-s+a);const c=function(e,t){return(0,l.YN)(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:i[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:i[e.meta.terminalNodes[0]-1]});if(1!=c)for(let e=0;e<n.length;++e)n[e]=(0,l.YN)(n[e]/c),i[e]=(0,l.YN)(i[e]/c)}(v,o),function(e,t,n){if("PEPTIDE"===e){b(t,e);const n=w(t,t.meta.rNodes[1]);n?.removedAtom&&(t.terminalR2Atom=n.removedAtom)}else n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(w(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],y(t.bonds,t.meta),b(t,e),w(t,t.meta.rNodes[1]),w(t,t.meta.rNodes[0]),w(t,t.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],E(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),b(t,e),w(t,t.meta.rNodes[1]))}(i,v,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===p.u.HYDROGEN&&(w(e,t+1),--t),++t}(v),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)"oh"===e.atoms.atomTypes[t]?.toLowerCase()&&(e.atoms.atomTypes[t]="O"),"?"===e.atoms.atomTypes[t]&&(e.atoms.atomTypes[t]="H"),++t}(v),function(e){const t=" RGROUPS=(1 1)";for(let n=0;n<(e.atoms.kwargs?.length??0);n++){const i=e.atoms.kwargs[n];i&&i.includes(t)&&(e.atoms.kwargs[n]=i.replace(t,""))}}(v),v}var r;return null}(t,n,i,o,r);if(!a)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);(0,u.LQ)(e,s,a)}}function y(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const i=t.terminalNodes,o=e.atomPairs;let r=0,s=0;for(;r<o.length&&s<i.length;){for(let e=0;e<i.length;++e)for(let t=0;t<2;++t)o[r][t]===n[e]&&(i[e]=o[r][(t+1)%2],n.length,++s);++r}}function b(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=v(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=v(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function v(e,t,n){return[(0,l.YN)(e.atoms.x[t]-e.atoms.x[n]),(0,l.YN)(e.atoms.y[t]-e.atoms.y[n])]}function w(e,t){if(void 0!==t){const n=t-1,i=e.atoms,o=e.bonds,r=e.meta,s=i.atomTypes.splice(n,1)[0];i.x=C(Float32Array,i.x,n,1),i.y=C(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let e=0;e<r.terminalNodes.length;++e)r.terminalNodes[e]>t?--r.terminalNodes[e]:r.terminalNodes[e]===t&&(r.terminalNodes[e]=-1);for(let e=0;e<r.rNodes.length;++e)r.rNodes[e]>t?--r.rNodes[e]:r.rNodes[e]===t&&(r.rNodes[e]=-1);let a=0;for(;a<o.atomPairs.length;){const e=o.atomPairs[a][0],n=o.atomPairs[a][1];e===t||n===t?(o.atomPairs.splice(a,1),o.bondTypes=C(Uint32Array,o.bondTypes,a,1),o.bondConfiguration.has(a)&&o.bondConfiguration.delete(a),o.kwargs.has(a)&&o.kwargs.delete(a),--a):(o.atomPairs[a][0]=e>t?e-1:e,o.atomPairs[a][1]=n>t?n-1:n),++a}let l=Array.from(o.bondConfiguration.keys());return l.forEach((e=>{if(o.bondConfiguration.has(e)&&e>n){const t=o.bondConfiguration.get(e);o.bondConfiguration.delete(e),o.bondConfiguration.set(e-1,t)}})),l=Array.from(o.kwargs.keys()),l.forEach((e=>{if(o.kwargs.has(e)&&e>n){const t=o.kwargs.get(e);o.kwargs.delete(e),o.kwargs.set(e-1,t)}})),s?{removedAtom:s}:void 0}}function C(e,t,n,i){const o=new e(t.length-i);let r=0,s=0;for(;r<t.length;)r===n&&(r+=i),o[s]=t[r],++s,++r;return o}function S(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const i=t/e,o=Math.atan(i);n=e<0?Math.PI/2+o:-Math.PI/2+o}return n}function A(e,t){if(0!==t){const n=e.x,i=e.y,o=Math.cos(t),r=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=(0,l.YN)(t*o-i[e]*r),i[e]=(0,l.YN)(t*r+i[e]*o)}}}function x(e){M(e,!1)}function M(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const i=1===t?3:1;n.set(e,i)}}function E(e,t,n){const i=e.atoms.x,o=e.atoms.y;for(let e=0;e<i.length;++e)i[e]=(0,l.YN)(i[e]+t),void 0!==n&&(o[e]=(0,l.YN)(o[e]+n))}},294:(e,t,n)=>{"use strict";function i(e,t){return e[t.polymerType]?.[t.symbol]}function o(e,t){return!!e[t.polymerType]?.[t.symbol]}function r(e,t,n){let i=e[t.polymerType];i||(i=e[t.polymerType]={}),i[t.symbol]=n}n.d(t,{Cg:()=>s,LQ:()=>r,bq:()=>o,vF:()=>a,xb:()=>i});class s extends Map{constructor(e){super(e)}}class a{constructor(e,t){this.molfile=e,this.monomers=t}static createEmpty(){return new a("",new s(null))}}},330:(e,t,n)=>{"use strict";n.d(t,{kA:()=>o,pz:()=>s,qj:()=>r,vG:()=>a});var i=n(2003);function o(e,t){return e?e.columns.getUnusedName(t):t}function r(e,t){return o(e,`molfile(${t})`)}function s(e){let t;if(e===i.YI.PT||e===i.YI.UN)t="PEPTIDE";else{if(e!==i.YI.RNA&&e!==i.YI.DNA)throw new Error(`Unexpected alphabet '${e}'.`);t="RNA"}return t}function a(e){const t=7===e.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(e):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(e);return t?[parseInt(t[1],16)/256,parseInt(t[2],16)/256,parseInt(t[3],16)/256,t.length>4?parseInt(t[4],16)/256:.3]:null}},1093:(e,t,n)=>{"use strict";n(7362);class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(e,t,n)=>{"use strict";n.d(t,{e:()=>i});class i{static makePalette(e,t=!1,n=i){const o={};return e.forEach((e=>{const n=e[0],i=e[1];n.forEach(((e,n)=>{o[e]=this.colourPalette[i][t?0:n]}))})),new n(o)}constructor(e){this._palette=e}get(e,t){return this._palette[e]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(e,t,n)=>{"use strict";n.d(t,{O:()=>r,n:()=>o});var i=n(1858);class o{constructor(e,t=!0,n){return this.substructure=e,this.readOnly=t,this.logger=n,new Proxy(this,{set:(e,t,n)=>{if(this.logger?.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class r{constructor(){this.onChanged=new i.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&"logger"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(e,t,n)=>{"use strict";var i=n(6082),o=n(7362),r=n(6718);function s(e,t=!0){if(null==e)return"rgb(100,100,100)";const n=i.Color.fromHtml(e);if(t){const e=i.Color.g(n),t=i.Color.r(n),o=i.Color.b(n),r=Math.sqrt(Math.pow(0-t,2)+Math.pow(0-e,2)+Math.pow(0-o,2));if(r>210)return`rgb(${t/r*210},${e/r*210},${o/r*210})`}return i.Color.toRgb(n)}class a{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class l{}class c extends l{static get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,r.pj)().then((e=>{e.awaitLoaded(1/0).then((()=>{const t=e.getMonomerLib();t.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=t.getPolymerTypes();for(const e of this.polymerTypes){const n=t.getMonomerSymbolsByType(e);for(const i of n){const n=t.getMonomer(e,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][e]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(o.e.colourPalette))}get(e,t){const n=c.palette.length,i=c.customMonomerColors[e],o=t??"PEPTIDE";if(i&&i[o])return i[o];const r=a.hashCode(e)%n;return s(c.palette[r])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(e,t,n)=>{"use strict";n.d(t,{BG:()=>s,sD:()=>l});var i=n(4328),o=n(1858),r=n(8070);function s(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const i=e.cell.column;if(t=t??(i?i.temp:null),!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,t]}class a{onKeyDown(e,t){}onKeyPress(e,t){}onMouseEnter(e,t){}onMouseLeave(e,t){}onMouseDown(e,t){}onMouseUp(e,t){}onMouseMove(e,t){}onClick(e,t){}onDoubleClick(e,t){}}class l extends a{constructor(e,t,n){super(),this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++l.viewerCounter,this.errors=[],this._onRendered=new o.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((e=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(e){this.logger.error(e)}})))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,r.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(e,t,n)=>{"use strict";n.d(t,{s:()=>i});const i={true:"1",false:"0"}},6882:(e,t,n)=>{"use strict";n.d(t,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),u=n(6718),h=n(9192),d=n(3856),p=n(673),m=n(3599),g=n(5553),f=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,i,r){if(super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})));const e=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter((t=>t.args.source===this.tableCol&&e.includes(t.args.key)))),200).subscribe((e=>{this.reset()}))),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter((e=>e.args.source===this.tableCol&&e.args.key===l.gp.positionShift))),200).subscribe((e=>{this.reset()})))}}calculateFontBasedSpacing(e){const t=e.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const e=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof e||isNaN(e)||(n=Math.max(e,1))}return{lineHeight:Math.max(1.4*n,t.fontBoundingBoxAscent+t.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(e){return"true"===e.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(e,t,n,i,o,r){if(this.dirty)try{this.reset()}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n)}const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(e),l=t-2*this.padding;let c=0;const u=[];if(i.length>0)for(let t=o;t<i.length;t++){const n=i.getOriginal(t),o=this.props.monomerToShort(n,r);u.push({text:o,posIdx:t}),c=Math.max(c,e.measureText(o).width)}if(0===u.length)return{lineLayouts:[],lineHeight:s};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,g=Math.max(0,Math.floor(m/s)),f=[];let y=0;for(let e=0;e<g&&y<u.length;e++){const t=[];for(let e=0;e<p&&y<u.length;e++){const n=u[y],i=this.padding+e*(d+a);t.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}f.push({lineIdx:e,elements:t})}return{lineLayouts:f,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,u.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(e){const t=new Array(e.length+1);t[0]=this.padding;for(let n=1;n<t.length;n++)t[n]=t[n-1]+e[n-1];let n=t[0];for(let e=1;e<t.length;e++)t[e]?n=t[e]:t[e]=n;return t}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(t/i)+o,s=n.splitter(e),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let e=o;e<a;++e){const i=s.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[e-o]=a,c+=a,c>t)break}return l}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+t,r=n.getSplitted(e),s=Math.min(o,r.length);let a=this._monomerLengthList[e];if(null===a||a.length!=s-t){a=this._monomerLengthList[e]=new Array(r.length);let i=0;for(let e=t;e<s;++e){const o=r.getOriginal(e),s=this.props.monomerToShort(o,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[e-t]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,s=Math.ceil(this.colWidth/o)+r;for(let e=n;e<i;e++){if(this._processedRows.get(e)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e,s),i=Math.min(s,n.length);i-r>t.length&&t.push(...new Array(i-r-t.length).fill(o));let a=0;for(let e=r;e<i;++e){const i=n.getOriginal(e),o=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(t[e-r]=Math.max(t[e-r]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(e,!0)}return t}getPosition(e,t,n,i){const[o,r]=this.getCellMonomerLengths(e,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e).length?null:function(e,t,n){if((n??0)>0&&t<(e[0]??0)+n)return-1;t-=n??0;let i,o=100,r=0,s=e.length-1;for(;r<=s;){if(i=Math.floor((s+r)/2),e[i]<=t&&t<e[i+1])return i;if(t<e[i]?s=i-1:r=i+1,--o<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t,i)}setMonomerLengthLimit(e){this.monomerLengthLimit!=e&&(this.monomerLengthLimit=e,this.dirty=!0)}setSeparatorWidth(e){this.separatorWidth!=e&&(this.props.separatorWidth=e,this.dirty=!0)}get positionShift(){const e=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(e)?0:Math.max(e,0)}render(e,t,n,i,r,a,c){const u=a.grid?.canvas===e.canvas;if(!this.seqHelper)return;const m=this.tableCol,g=this.positionShift;e.save();try{const c=this.seqHelper.getSeqHandler(m);let h=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const e=parseInt(m.getTag(d.gp.maxMonomerLength));h=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in m.temp){const e=m.temp[".mm.cellRenderer.maxMonomerLength"],t="number"==typeof e?e:parseInt(e);h=!isNaN(t)&&t?t:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=h){let e=0;const t=8;e=m.temp[".mm.cellRenderer.gapLength"]??e,this.setMonomerLengthLimit(h),this.setSeparatorWidth(c.isMsa()?t:e),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false,this.dirty=!0}const f=a.cell.rowIndex,b=a.cell.value;u&&(i=v(a.grid,e,t,i,window.devicePixelRatio)),e.beginPath(),e.rect(t,n,i,r),e.clip(),e.font=this.props?.font??"12px monospace",e.textBaseline="top";const w=m.meta.units,C=m.getTag(l.gp.aligned),S=m.getTag(l.gp.separator)??"",A=u?c.getSplitted(f):c.splitter(b);let x=d.yg.classic;C?.includes("MSA")&&w===l.Hi.SEPARATOR&&(x=d.yg.MSA);const M=m.temp["reference-sequence"],E=this.tableCol.temp["current-word"],T=(()=>{const e=(0,c.splitter)(null!=M&&""!==M?M:E??"");return s().count(0).take(e.length).slice(g).map((t=>e.getCanonical(t))).toArray()})(),_=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)){const s=[],l=this.calculateMultiLineLayoutDynamic(e,i,r,A,g,h);let u=n+this.padding;1===l.lineLayouts.length&&(u=n+(r-l.lineHeight)/2);for(const i of l.lineLayouts){const r=u+i.lineIdx*l.lineHeight;for(const u of i.elements){const h=t+u.x,p=u,f=p.posIdx,b=A.getCanonical(f);let v=y;const w=this.getMonomerLib();w&&(v=w.getMonomerTextColor(c.defaultBiotype,b));let C=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&T.length>0){const e=f-g;e>=0&&e<T.length&&b===T[e]&&(C=.7)}s.push({lineIdx:i.lineIdx,monomerIdx:f-g,bounds:new o.Rect(u.x,r-n,u.width,l.lineHeight),sequencePosition:f}),(0,d.oZ)(e,p.om,h,r,u.width,l.lineHeight,{color:v,isMultiLineContext:!0,transparencyRate:C,selectedPosition:isNaN(_)||_<1?void 0:_,wordIdx:f})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,s)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(g)?e.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,i);u||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,i)));const s=this.props.separatorWidth+1*this.props.fontCharWidth,l=Math.min(A.length,Math.ceil(i/s)+g);for(let s=g;s<l;++s){const l=s<A.length?A.getOriginal(s):c.defaultGapOriginal,u=s<A.length?A.getCanonical(s):c.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(c.defaultBiotype,u));const m={color:p,pivot:0,left:!0,transparencyRate:0,separator:S,last:s===A.length-1,drawStyle:x,maxWord:o,wordIdx:s-g,gridCell:a,referenceSequence:T,maxLengthOfMonomer:h,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(_)||_<1?void 0:_-g};(0,d.oZ)(e,l,t+this.padding+this._leftThreeDotsPadding,n,i,r,m)}if(this.shouldRenderShiftedThreeDots(g)){const s={color:y,pivot:0,left:!0,transparencyRate:0,separator:S,last:!1,drawStyle:x,maxWord:o,wordIdx:0,gridCell:a,maxLengthOfMonomer:h,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,d.oZ)(e,"...",t+this.padding,n,i,r,s)}}}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n),this.errors.push(e)}finally{e.restore()}}shouldRenderShiftedThreeDots(e){return e>0&&(!this.gridCol||!this.gridCol.dart||!this.gridCol.grid||!this.gridCol.grid.dart||(this.gridCol.grid.props.colHeaderHeight??0)<=50)}onMouseMove(e,t){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==e.tableRowIndex)return;const o=this.positionShift,r=e.bounds,s=t.offsetX-e.gridColumn.left+(e.gridColumn.left-r.x),a=t.offsetY-r.y;this.gridCol?.grid?.canvas&&(this.gridCol.grid.canvas.style.cursor="default");let c=null;const u=this._cellBounds.get(e.tableRowIndex);if(u){for(const e of u)if(e.bounds.contains(s,a)){c=e.monomerIdx;break}}else{const t=this.shouldRenderShiftedThreeDots(o)&&(this._leftThreeDotsPadding??0)>0?this._leftThreeDotsPadding:0;c=this.getPosition(e.tableRowIndex,s,r.width,t)}this.logger.debug(`${n}, argsX: ${s}, argsY: ${a}, left: ${c}`);const h=this.seqHelper.getSeqHandler(this.tableCol),d=h.getSplitted(e.tableRowIndex);if(null!==c&&c>=0&&c+o<d.length){const n=h.alphabet??l.YI.UN,r={position:c,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:d.getCanonical(c+o)},s=[];let a=this._monomerStructureMap[r.symbol];if(!a){const e=this.getMonomerLib();a=this._monomerStructureMap[r.symbol]=e?e.getTooltip(r.biotype,r.symbol):i.divText("Monomer library is not available")}s.push(a),i.tooltip.show(i.divV(s),t.x+16,t.y+16),(0,g.WN)(e,r)}else-1===c?i.tooltip.show(i.divText(`${Math.min(o,d.length)} hidden monomers`),t.x+16,t.y+16):i.tooltip.hide(),(0,g.WN)(e,null)}}function v(e,t,n,i,o){return e?Math.max(Math.min(e.canvas.width/o-n,i)):Math.max(t.canvas.width/o-n,0)}},3856:(e,t,n)=>{"use strict";n.d(t,{Mn:()=>u,gp:()=>c,oZ:()=>p,yg:()=>h});var i=n(6082),o=n(7278);const r="rgb(100,100,100)",s="#808080",a="rgb(0,0,0)",l=o.zS;var c,u,h;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(c||(c={})),function(e){e.applyToBackground=".m.cellRenderer.applyToBackground"}(u||(u={})),function(e){e.MSA="MSA",e.classic="classic"}(h||(h={}));const d=new class{constructor(){this.color=r,this.pivot=0,this.left=!1,this.transparencyRate=0,this.separator="",this.last=!1,this.drawStyle=h.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0,this.isMultiLineContext=!1,this.lineNumber=0}};function p(e,t,n,o,c,u,p){var m,g,f;const y={...d,...p};if(y.isMultiLineContext){e.textBaseline="middle",e.textAlign="center";let i=t;null!=y.maxLengthOfMonomer&&(i=l(i,y.maxLengthOfMonomer));const s=Math.max(.1,1-(y.transparencyRate??0));e.globalAlpha=s;const h=e.measureText(i),d=h.fontBoundingBoxAscent+h.fontBoundingBoxDescent,p=o+(u-d)/2+h.fontBoundingBoxAscent;let m=y.color??r;return m&&m!==r||(m=a),e.fillStyle=m,y.selectedPosition===y.wordIdx+1&&(e.save(),e.fillStyle="rgba(60, 177, 115, 0.2)",e.fillRect(n,o,c,u),e.restore(),e.fillStyle=m),e.fillText(i,n+c/2,p),e.globalAlpha=1,e.textBaseline="top",e.textAlign="start",n+c}p.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let b=t.substring(0),v=y.last?"":y.separator;y.drawStyle===h.MSA&&(v="");let w=!0,C=!0,S="difference";if(null!=y.gridCell&&null!=y.gridCell.cell.column&&(w=y.gridCell.cell.column.temp["color-code"]??!0,C=y.gridCell.cell.column.temp["compare-with-current"]??!0,S=y.gridCell.cell.column.temp["highlight-difference"]??"difference"),y.referenceSequence){const e=y.referenceSequence[y.wordIdx];C&&y.referenceSequence.length>0&&"difference"===S&&(y.transparencyRate=b==e?.7:y.transparencyRate),C&&y.referenceSequence.length>0&&"equal"===S&&(y.transparencyRate=b!=e?.7:y.transparencyRate)}null!=y.maxLengthOfMonomer&&(b=l(b,y.maxLengthOfMonomer));const A=b+v;(m=y.monomerTextSizeMap)[A]??(m[A]=e.measureText(A));let x=y.monomerTextSizeMap[A];(g=y.monomerTextSizeMap)[b]??(g[b]=e.measureText(b));let M=y.monomerTextSizeMap[b].width;const E=u/2-(x.fontBoundingBoxAscent+x.fontBoundingBoxDescent)/2+1;(f=y.monomerTextSizeMap)[v]??(f[v]=e.measureText(v));const T=y.monomerTextSizeMap[v].width;function _(t,r){let l=w?y.color:a;y.selectedPosition===y.wordIdx+1&&(e.fillStyle="rgba(60, 177, 115, 0.2)",e.fillRect(n+t-4,o-5,y.monomerTextSizeMap[b].width+8,u+10),l=i.Color.toHtml(i.Color.setAlpha(i.Color.fromHtml(l),255))),e.fillStyle=l,e.globalAlpha=1-y.transparencyRate,y.drawStyle===h.classic&&(e.fillText(b,n+t,o+E),e.fillStyle=s,e.fillText(v,n+r,o+E)),y.drawStyle===h.MSA&&e.fillText(b,n+t,o+E),e.globalAlpha=1}x=x.width,y.drawStyle===h.MSA&&(M=y.maxWord[y.wordIdx],x=y.maxWord[y.wordIdx]);const I=(y.maxWord[y.wordIdx]??0)-(y.maxWord[0]??0);if(y.left||x>c)return _(I,I+M),n+I+M+T;{const e=(c-x)/2;return _(e,e+M),n+I+e+M}}},6307:(e,t,n)=>{"use strict";n.d(t,{F:()=>s});var i=n(7389),o=n(6082),r=n(439);function s(e,t,n){let s=0,a=null;for(const t of Object.values(e))s+=t,a=null===a?t:Math.max(a,t);const l=a/s,c=Object.assign({},...Array.from(Object.entries(e)).sort(((e,t)=>t[1]-e[1])).map((([e,a])=>{const c=a/s;let u;try{const i=n.getMonomerColors(t,e);u=i?.backgroundcolor||"#CCCCCC"}catch(t){console.warn(`Failed to get colors for monomer ${e}:`,t),u="#CCCCCC"}const h=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});h.style.width=50*c/l+"px",h.style.backgroundColor=u,r._S===e&&(h.style.borderWidth="1px",h.style.borderStyle="solid",h.style.borderColor=o.Color.toHtml(o.Color.lightGray));const d=r._S===e?"-":e,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([h,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),u=i.tableFromMap(c);return Array.from(u.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),u}},3151:(e,t,n)=>{"use strict";n.d(t,{EK:()=>l,Ec:()=>r,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>o});const i=["symbol","molfile","rgroups","name"],o="MonomerName",r={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(e,t,n)=>{"use strict";function i(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?i(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function o(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?o(e.$thrownJsError):void 0}function r(e){return[i(e),o(e)]}n.d(t,{AP:()=>r})},3516:(e,t,n)=>{"use strict";n.d(t,{m:()=>r});var i=n(6082),o=n(439);class r{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const i=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=i.Column.fromStrings("description",this.descriptionsArray),t=i.Column.fromStrings("sequence",this.sequencesArray);return t.semType=i.SEMTYPE.MACROMOLECULE,t.meta.units=o.Hi.FASTA,[i.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},6873:(e,t,n)=>{"use strict";n.d(t,{Hx:()=>u,dW:()=>c});var i=n(6082),o=n(1991),r=n.n(o),s=n(2003),a=n(7278),l=n(439);function c(e=1e4){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const o=[];return o.push(n),o.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),o}function u(e,t=s.Hi.SEPARATOR,n=s.YI.PT,o=(t===s.Hi.SEPARATOR?"-":void 0),c=void 0,u="seq",h=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,g=i.Column.fromType(i.COLUMN_TYPE.STRING,u,h);g.semType=i.SEMTYPE.MACROMOLECULE,g.meta.units=t,g.setTag(s.gp.alphabet,n),t==s.Hi.SEPARATOR&&g.setTag(s.gp.separator,o);const f=e.getSeqHandler(g);for(let e=0;e<h;e++){const n=r().count(0).take(d).map((e=>p[Math.floor(Math.random()*m)])).toArray(),i=f.joiner(new a.Mu(n,l.b9[t]));g.set(e,i)}return g}},439:(e,t,n)=>{"use strict";n.d(t,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>o,_S:()=>h,b9:()=>d,gp:()=>r,ot:()=>p,q7:()=>u,z1:()=>a});var i,o,r,s=n(2738);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm",e.CUSTOM="custom"}(i||(i={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(o||(o={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions",e.positionShift=".positionShift",e.selectedPosition=".selectedPosition"}(r||(r={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},u=[new s.a(o.PT,c.fasta.peptide,.5),new s.a(o.DNA,c.fasta.dna,.55),new s.a(o.RNA,c.fasta.rna,.55)],h="",d={[i.FASTA]:"-",[i.SEPARATOR]:"",[i.HELM]:"*"},p=" , "},2003:(e,t,n)=>{"use strict";n.d(t,{Hi:()=>i.Hi,J9:()=>o.J9,Qf:()=>o.Qf,YI:()=>i.YI,dh:()=>o.dh,gp:()=>i.gp,mn:()=>o.mn,q7:()=>i.q7,qp:()=>o.qp,z1:()=>i.z1,zS:()=>o.zS});var i=n(439),o=n(7278)},2738:(e,t,n)=>{"use strict";n.d(t,{X:()=>o,a:()=>i});class i{constructor(e,t,n){this.name=e,this.alphabet=t,this.cutoff=n}}class o extends i{constructor(e,t,n){super(e.name,e.alphabet,e.cutoff),this.freq=t,this.similarity=n}}},7278:(e,t,n)=>{"use strict";n.d(t,{Iv:()=>y,J9:()=>p,Mu:()=>h,Qf:()=>w,dh:()=>g,mn:()=>A,p0:()=>S,pc:()=>C,qp:()=>f,tm:()=>m,zS:()=>v});var i=n(6082),o=n(1991),r=n.n(o),s=n(3527),a=n(3629),l=n(2738),c=n(439),u=(n(8924),n(1093),n(4152),n(8438));class h{get length(){return this.mList.length}isGap(e){return this.getOriginal(e)===this.gapOriginalMonomer}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");const t=this.mList[e];return t!==this.gapOriginalMonomer?t:c._S}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}getCanonicalRegion(e,t){const n=Math.min(Math.max(0,e),this.length),i=Math.max(Math.min(this.length,t),0)-n,o=this.gapOriginalMonomer;return new Array(i).fill(null).map(((e,t)=>{const i=this.mList[t+n];return i===o?c._S:i}))}getOriginalRegion(e,t){const n=Math.min(Math.max(0,e),this.length),i=Math.max(Math.min(this.length,t),0);return new Array(i-n).fill(null).map(((e,t)=>this.mList[t+n]))}get gapOriginal(){return this.gapOriginalMonomer}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class d{get length(){return this.seqS.length}isGap(e){return this.getOriginal(e)===c.b9[c.Hi.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?c._S:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}getCanonicalRegion(e,t){const n=Math.max(0,e),i=Math.min(this.length,t)-n,o=c.b9[c.Hi.FASTA];return new Array(i).fill(null).map(((e,t)=>{const i=this.seqS[t+n];return i===o?c._S:i}))}getOriginalRegion(e,t){const n=Math.max(0,e),i=Math.min(this.length,t);return this.seqS.slice(n,i)}get gapOriginal(){return c.b9[c.Hi.FASTA]}constructor(e){this.seqS=e}}const p=e=>{const t=r()(e.toString().matchAll(c.B5)).map((e=>e[2]??e[1])).toArray();return new h(t,c.b9[c.Hi.FASTA])},m=e=>e?new d(e):new h([],c.b9[c.Hi.FASTA]);function g(e,t=void 0){return n=>{if(n){let i;const o=new RegExp(`(?<=^|\\${e})("-"|'-'|[^\\${e}]*)(?=\\${e}|$)`,"g");return void 0!==t?(o.lastIndex=0,i=r()(n.matchAll(o)).take(t).map((e=>e[0])).toArray()):i=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t),new h(i,c.b9[c.Hi.SEPARATOR])}return new h([],c.b9[c.Hi.SEPARATOR])}}const f=e=>{const t=e.split("$")[0].split("|"),n=r()(t.map((e=>(e.match(/(?<=\{).+(?=})/)?.[0]?.split(".")??[]).map((e=>(0,u.D)(e)))))).flatten().toArray();return new h(n,c.b9[c.Hi.HELM])};function y(e,t,n=void 0){if(e.toLowerCase().startsWith(c.Hi.FASTA))return p;if(e.toLowerCase().startsWith(c.Hi.SEPARATOR))return g(t,n);if(e.toLowerCase().startsWith(c.Hi.HELM))return f;throw new Error(`Unexpected units ${e} .`)}const b=/([^\W_]+)/g;function v(e,t){if(e.length<=t)return e;const n=e.match(b),i=e.length>t||(n?.length??0)>1,o=n?.[0]??" ";return i?o.substring(0,t-1)+"…":o}function w(e){switch(e){case c.YI.DNA:return c.Vl.fasta.dna;case c.YI.RNA:return c.Vl.fasta.rna;case c.YI.PT:return c.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${e}'.`)}}function C(e,t,n="-"){const i=t.map((t=>{const i=function(e,t,n="-"){const i=new Set([...new Set(Object.keys(e)),...t]);i.delete(n);const o=[],r=[];for(const n of i)o.push(n in e?e[n]:0),r.push(t.has(n)?1:0);const l=new s.Mi(o),c=new s.Mi(r);return(0,a.KE)(l,c)/((0,a.wQ)(l)*(0,a.wQ)(c))}(e,t.alphabet,n);return new l.X(t,e,i)}));let o;const r=Math.max(...i.map((e=>e.similarity>e.cutoff?e.similarity:-1)));return o=r>0?i.find((e=>e.similarity===r)).name:c.YI.UN,o}function S(e,t,n="-"){const i=Object.keys(e),o=/\(|\)/;return C(i.filter((e=>3===e.split(o).filter((e=>!!e)).length)).length>.8*i.length?Object.entries(e).reduce(((e,[t,n])=>{const i=t.split(o)[1];return i&&(e[i]=n),e}),{}):e,t,n)}function A(e){const t=e.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let n=t.find((e=>{const t=e.meta.units;return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},8312:(e,t,n)=>{"use strict";n.d(t,{Q:()=>o});var i=n(6082);async function o(){const e=i.Func.find({package:"Bio",name:"getSeqHelper"});if(0===e.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await e[0].prepare().call()).getOutputParamValue()}},3077:(e,t,n)=>{"use strict";n.d(t,{R:()=>o});var i=n(6082);function o(e,t){const n=e=>{const t=s.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,s=i.DataFrame.create(r),a=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=a.getSplitted(e);for(let i=0;i<t.length;++i){const r=t.getCanonical(i);((o[i]??null)||n(i)).set(e,r,!1)}}return s}},7602:(e,t,n)=>{"use strict";n.d(t,{g:()=>r});var i,o=n(9192);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(i||(i={}));class r{constructor(e){this.logger=e,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(e,t){const n=++this.syncCounter;this.logger.debug(`${e}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${e}, SYNC syncId = ${n}, START `),await t(),this.logger.debug(`${e}, SYNC syncId = ${n}, END `)})).catch((t=>{const[i,r]=(0,o.AP)(t);this.logger.error(`${e}, SYNC syncId = ${n}, ERROR:\n${i}`,void 0,r),this.errors.push(t)}))}resetErrors(){const e=this.errors;return this.errors=[],e}}},4326:(e,t,n)=>{"use strict";n.d(t,{Fo:()=>u,Lp:()=>r,P4:()=>s,fH:()=>o,gp:()=>i,lT:()=>l,mH:()=>a});var i,o,r,s,a,l,c=n(6082);!function(e){e.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(e){e.Entropy="Entropy",e.full="100%"}(o||(o={})),function(e){e.TOP="top",e.MIDDLE="middle",e.BOTTOM="bottom"}(r||(r={})),function(e){e.LEFT="left",e.CENTER="center",e.RIGHT="right"}(s||(s={})),function(e){e.AUTO="auto",e.ON="on",e.OFF="off"}(a||(a={})),function(e){e.Filtered="Filtered",e.Selected="Selected"}(l||(l={}));const u=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=o.Entropy,this.positionWidth=20,this.verticalAlignment=r.MIDDLE,this.horizontalAlignment=s.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=25,this.maxHeight=300,this.maxMonomerLetters=5,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},6869:(e,t,n)=>{"use strict";var i;n.d(t,{o:()=>i}),function(e){e.BASE="HELM_BASE",e.SUGAR="HELM_SUGAR",e.LINKER="HELM_LINKER",e.AA="HELM_AA",e.CHEM="HELM_CHEM",e.BLOB="HELM_BLOB",e.NUCLEOTIDE="HELM_NUCLETIDE"}(i||(i={}))},5540:(e,t,n)=>{"use strict";e=n.hmd(e);var i,o=(i="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(e={}){var t,n,o=void 0!==e?e:{};o.ready=new Promise((function(e,i){t=e,n=i}));var r,s=Object.assign({},o),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),i&&(c=i),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(r=e=>{var t=new XMLHttpRequest;return t.open("GET",e,!1),t.responseType="arraybuffer",t.send(null),new Uint8Array(t.response)})),o.print||console.log.bind(console);var u,h,d=o.printErr||console.warn.bind(console);Object.assign(o,s),s=null,o.arguments&&o.arguments,o.thisProgram&&o.thisProgram,o.quit&&o.quit,o.wasmBinary&&(u=o.wasmBinary),o.noExitRuntime,"object"!=typeof WebAssembly&&E("no native wasm support detected");var p,m,g,f=!1;function y(){var e=h.buffer;o.HEAP8=p=new Int8Array(e),o.HEAP16=new Int16Array(e),o.HEAP32=new Int32Array(e),o.HEAPU8=m=new Uint8Array(e),o.HEAPU16=new Uint16Array(e),o.HEAPU32=g=new Uint32Array(e),o.HEAPF32=new Float32Array(e),o.HEAPF64=new Float64Array(e)}var b,v,w=[],C=[],S=[],A=0,x=null,M=null;function E(e){o.onAbort&&o.onAbort(e),d(e="Aborted("+e+")"),f=!0,e+=". Build with -sASSERTIONS for more info.";var t=new WebAssembly.RuntimeError(e);throw n(t),t}function T(e){return e.startsWith("data:application/octet-stream;base64,")}function _(e){try{if(e==b&&u)return new Uint8Array(u);if(r)return r(e);throw"both async and sync fetching of the wasm failed"}catch(e){E(e)}}function I(e,t,n){return function(e){return u||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return _(e)})):fetch(e,{credentials:"same-origin"}).then((function(t){if(!t.ok)throw"failed to load wasm binary file at '"+e+"'";return t.arrayBuffer()})).catch((function(){return _(e)}))}(e).then((function(e){return WebAssembly.instantiate(e,t)})).then((function(e){return e})).then(n,(function(e){d("failed to asynchronously prepare wasm: "+e),E(e)}))}function L(e){for(;e.length>0;)e.shift()(o)}function N(e){this.excPtr=e,this.ptr=e-24,this.set_type=function(e){g[this.ptr+4>>2]=e},this.get_type=function(){return g[this.ptr+4>>2]},this.set_destructor=function(e){g[this.ptr+8>>2]=e},this.get_destructor=function(){return g[this.ptr+8>>2]},this.set_caught=function(e){e=e?1:0,p[this.ptr+12|0]=e},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(e){e=e?1:0,p[this.ptr+13|0]=e},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(e,t){this.set_adjusted_ptr(0),this.set_type(e),this.set_destructor(t)},this.set_adjusted_ptr=function(e){g[this.ptr+16>>2]=e},this.get_adjusted_ptr=function(){return g[this.ptr+16>>2]},this.get_exception_ptr=function(){if(D(this.get_type()))return g[this.excPtr>>2];var e=this.get_adjusted_ptr();return 0!==e?e:this.excPtr}}function P(e){var t=h.buffer;try{return h.grow(e-t.byteLength+65535>>>16),y(),1}catch(e){}}function R(e){return o["_"+e]}T(b="wasmDbscan.wasm")||(v=b,b=o.locateFile?o.locateFile(v,c):c+v);var $="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function O(e,t,n,i,o){var r={string:e=>{var t=0;return null!=e&&0!==e&&(t=function(e){var t=function(e){for(var t=0,n=0;n<e.length;++n){var i=e.charCodeAt(n);i<=127?t++:i<=2047?t+=2:i>=55296&&i<=57343?(t+=4,++n):t+=3}return t}(e)+1,n=B(t);return function(e,t,n){!function(e,t,n,i){if(!(i>0))return 0;for(var o=n+i-1,r=0;r<e.length;++r){var s=e.charCodeAt(r);if(s>=55296&&s<=57343&&(s=65536+((1023&s)<<10)|1023&e.charCodeAt(++r)),s<=127){if(n>=o)break;t[n++]=s}else if(s<=2047){if(n+1>=o)break;t[n++]=192|s>>6,t[n++]=128|63&s}else if(s<=65535){if(n+2>=o)break;t[n++]=224|s>>12,t[n++]=128|s>>6&63,t[n++]=128|63&s}else{if(n+3>=o)break;t[n++]=240|s>>18,t[n++]=128|s>>12&63,t[n++]=128|s>>6&63,t[n++]=128|63&s}}t[n]=0}(e,m,t,n)}(e,n,t),n}(e)),t},array:e=>{var t,n,i=B(e.length);return t=e,n=i,p.set(t,n),i}},s=R(e),a=[],l=0;if(i)for(var c=0;c<i.length;c++){var u=r[n[c]];u?(0===l&&(l=F()),a[c]=u(i[c])):a[c]=i[c]}var h=s.apply(null,a);return function(e){return 0!==l&&G(l),function(e){return"string"===t?(n=e)?function(e,t,n){for(var i=t+n,o=t;e[o]&&!(o>=i);)++o;if(o-t>16&&e.buffer&&$)return $.decode(e.subarray(t,o));for(var r="";t<o;){var s=e[t++];if(128&s){var a=63&e[t++];if(192!=(224&s)){var l=63&e[t++];if((s=224==(240&s)?(15&s)<<12|a<<6|l:(7&s)<<18|a<<12|l<<6|63&e[t++])<65536)r+=String.fromCharCode(s);else{var c=s-65536;r+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else r+=String.fromCharCode((31&s)<<6|a)}else r+=String.fromCharCode(s)}return r}(m,n,i):"":"boolean"===t?Boolean(e):e;var n,i}(e)}(h)}var k,H={__cxa_throw:function(e,t,n){throw new N(e).init(t,n),e},abort:function(){E("")},emscripten_memcpy_big:function(e,t,n){m.copyWithin(e,t,t+n)},emscripten_resize_heap:function(e){var t,n=m.length,i=2147483648;if((e>>>=0)>i)return!1;for(var o=1;o<=4;o*=2){var r=n*(1+.2/o);if(r=Math.min(r,e+100663296),P(Math.min(i,(t=Math.max(e,r))+(65536-t%65536)%65536)))return!0}return!1}},F=(function(){var e,t,i,r,s={env:H,wasi_snapshot_preview1:H};function a(e,t){var n,i=e.exports;return o.asm=i,h=o.asm.memory,y(),o.asm.__indirect_function_table,n=o.asm.__wasm_call_ctors,C.unshift(n),function(){if(A--,o.monitorRunDependencies&&o.monitorRunDependencies(A),0==A&&(null!==x&&(clearInterval(x),x=null),M)){var e=M;M=null,e()}}(),i}if(A++,o.monitorRunDependencies&&o.monitorRunDependencies(A),o.instantiateWasm)try{return o.instantiateWasm(s,a)}catch(e){d("Module.instantiateWasm callback failed with error: "+e),n(e)}(e=u,t=b,i=s,r=function(e){a(e.instance)},e||"function"!=typeof WebAssembly.instantiateStreaming||T(t)||"function"!=typeof fetch?I(t,i,r):fetch(t,{credentials:"same-origin"}).then((function(e){return WebAssembly.instantiateStreaming(e,i).then(r,(function(e){return d("wasm streaming compile failed: "+e),d("falling back to ArrayBuffer instantiation"),I(t,i,r)}))}))).catch(n)}(),o._dbscan=function(){return(o._dbscan=o.asm.dbscan).apply(null,arguments)},o._malloc=function(){return(o._malloc=o.asm.malloc).apply(null,arguments)},o._free=function(){return(o._free=o.asm.free).apply(null,arguments)},function(){return(F=o.asm.stackSave).apply(null,arguments)}),G=function(){return(G=o.asm.stackRestore).apply(null,arguments)},B=function(){return(B=o.asm.stackAlloc).apply(null,arguments)},D=function(){return(D=o.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function e(){k||(k=!0,o.calledRun=!0,f||(L(C),t(o),o.onRuntimeInitialized&&o.onRuntimeInitialized(),function(){if(o.postRun)for("function"==typeof o.postRun&&(o.postRun=[o.postRun]);o.postRun.length;)e=o.postRun.shift(),S.unshift(e);var e;L(S)}()))}A>0||(function(){if(o.preRun)for("function"==typeof o.preRun&&(o.preRun=[o.preRun]);o.preRun.length;)e=o.preRun.shift(),w.unshift(e);var e;L(w)}(),A>0||(o.setStatus?(o.setStatus("Running..."),setTimeout((function(){setTimeout((function(){o.setStatus("")}),1),e()}),1)):e()))}if(o.ccall=O,o.cwrap=function(e,t,n,i){var o=!n||n.every((e=>"number"===e||"boolean"===e));return"string"!==t&&o&&!i?R(e):function(){return O(e,t,n,arguments)}},M=function e(){k||V(),k||(M=e)},o.preInit)for("function"==typeof o.preInit&&(o.preInit=[o.preInit]);o.preInit.length>0;)o.preInit.pop()();return V(),e.ready});"object"==typeof exports?e.exports=o:"function"==typeof define&&n.amdO?define([],(function(){return o})):"object"==typeof exports&&(exports.exportCppDbscanLib=o)},6295:(e,t,n)=>{"use strict";n.d(t,{$1:()=>s,Hf:()=>u,Hr:()=>M,Ii:()=>f,Qj:()=>m,T6:()=>x,TK:()=>S,be:()=>g,gt:()=>v,ij:()=>w,jL:()=>c,lO:()=>p,lP:()=>b,rR:()=>y,tO:()=>a,v_:()=>l,w_:()=>h,yK:()=>C,zn:()=>d});var i=n(8774),o=n(8498),r=n(6863);function s(e,t){const n=e.trueCount()+t.trueCount();if(0==n)return 1;const i=e.andWithCountBits(t,!0);return i/(n-i)}function a(e,t){return 1-s(e,t)}function l(e,t){return A(s(new i.A(e,32*e.length),new i.A(t,32*t.length)))}function c(e,t){let n=0;for(let i=0;i<e.length;i++)n+=Math.pow(e[i]-t[i],2);return Math.sqrt(n)}function u(e,t){let n=0;for(let i=0;i<e.length;i++)n+=Math.abs(e[i]-t[i]);return n}function h(e,t){let n=0,i=0,o=0;for(let r=0;r<e.length;r++)n+=e[r]*t[r],i+=e[r]*e[r],o+=t[r]*t[r];return(1-n/(Math.sqrt(i)*Math.sqrt(o)))/2}function d(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount();return 0==n?0:2*e.andWithCountBits(t,!0)/n}(e,t)}function p(e,t){return 1-function(e,t){const n=e.trueCount()*t.trueCount();return 0==n?0:e.andWithCountBits(t,!0)/Math.sqrt(n)}(e,t)}function m(e,t){return Math.sqrt(e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0))}function g(e,t){return e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0)}function f(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount(),i=e.andWithCountBits(t,!0);return i/(2*n-3*i)}(e,t)}function y(e,t){return A(function(e,t){const n=e.trueCount()+t.trueCount(),i=e.trueCount()*t.trueCount();return 0==i?0:e.andWithCountBits(t,!0)*n/(2*i)}(e,t))}function b(e,t){return A(function(e,t){const n=e.trueCount()+t.trueCount(),i=e.trueCount()*t.trueCount();return 0==i?0:(e.andWithCountBits(t,!0)*n-i)/i}(e,t))}function v(e,t){return 1-function(e,t){const n=Math.min(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t)}function w(e,t){return A(function(e,t){const n=Math.max(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t))}function C(e,t){return A(function(e,t){return 0==e.length?0:e.andWithCountBits(t,!0)/e.length}(e,t))}function S(e,t){return A(function(e,t){const n=e.andWithCountBits(t,!0),i=e.countBits(!0)+t.countBits(!0),o=e.length,r=o-i+n;return n==o||r==o?1:n/i+r/(2*o-i)}(e,t))}function A(e){return e<=0?3402823e32:1/e-1}function x(e){if(e&&null!=e.range&&e.range>0){const t=e.range;return(e,n)=>Math.abs(e-n)/t}return(e,t)=>Math.abs(e-t)}function M(e){const t=function(e){const t=e?.mostCommon??new Set;return(e,n)=>{const i=e.length,o=n.length;let r=0,s=0,a=0;for(;s<i&&a<o;)e[s]===n[a]?(t?.has(e[s])||++r,++s,++a):e[s]<n[a]?++s:++a;return r}}(e);return(e,n)=>0===n.length||0===e.length?1e4:Math.min(e.length,n.length)/(t(e,n)+1e-4)}o.aT.Tanimoto,o.aT.Dice,o.aT.Asymmetric,o.aT.BraunBlanquet,o.aT.Cosine,o.aT.Kulczynski,o.aT.McConnaughey,o.aT.RogotGoldberg,o.aT.Russel,o.aT.Sokal,o.aT.Hamming,o.aT.Euclidean,o.aT.Tanimoto,o.aT.Dice,o.aT.Asymmetric,o.aT.BraunBlanquet,o.aT.Cosine,o.aT.Kulczynski,o.aT.McConnaughey,o.aT.RogotGoldberg,o.aT.Russel,o.aT.Sokal,o.aT.Hamming,o.aT.Euclidean,o.aT.Tanimoto,o.aT.Dice,o.aT.Cosine,o.aT.Tanimoto,o.aT.Asymmetric,o.aT.Cosine,o.aT.Sokal,r.Z.HAMMING,r.Z.LEVENSHTEIN,r.Z.MONOMER_CHEMICAL_DISTANCE,r.Z.NEEDLEMANN_WUNSCH},684:(e,t,n)=>{"use strict";n.d(t,{C0:()=>r,GP:()=>i,Gi:()=>a,YP:()=>c,_X:()=>s,n3:()=>o,vb:()=>l});const i="dim-red-preprocessing-function",o="supportedSemTypes",r="supportedTypes",s="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},6863:(e,t,n)=>{"use strict";function i(e={}){const t=function(){if(!e||!e.scoringMatrix||!e.alphabetIndexes)return(e,t)=>e===t?0:1;if(e.scoringMatrix.length!==Object.keys(e.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const t=e.alphabetIndexes,n=e.scoringMatrix,i=Math.min(...Object.keys(t).map((e=>e.charCodeAt(0))))+1,o=new Float32Array((n.length+i)*(n.length+i));return Object.entries(t).forEach((([e,i])=>{const r=n[i];Object.entries(t).forEach((([t,i])=>{o[e.charCodeAt(0)*n.length+t.charCodeAt(0)]=r[i]}))})),(e,t)=>1-o[e.charCodeAt(0)*n.length+t.charCodeAt(0)]}(),n=e?.threshold??0;return(e,i)=>{let o=0;const r=e.length,s=i.length,a=Math.ceil(Math.max(r,s)*(1-n));r!==s&&(o=Math.abs(r-s));let l=0;for(let n=0;n<Math.min(r,s);n++)if(e[n]!==i[n]&&(l+=t(e[n],i[n]),l>a))return 1;return l+=o,l/=Math.max(r,s),l}}n.d(t,{Z:()=>s,V:()=>a});var o=n(2787);const r={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(e,t)=>(0,o.I)(e,t)/Math.max(e.length,t.length)},[s.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:o,alphabetIndexes:s}={...r,...e};Object.entries(s).forEach((([e,n])=>t[e.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,r)=>{const s=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-i-(t-1)*i,a[1][t]=0;a[0][0]=0;for(let h=1;h<r.length+1;h++){a[u][0]=-i-(h-1)*i;for(let d=1;d<e.length+1;d++){const p=a[c][d-1]+o[t[e.charCodeAt(d-1)]][t[r.charCodeAt(h-1)]],m=a[c][d]-(s[d]||1===h||h===r.length?i:n),g=a[u][d-1]-(l[d-1]||1===d||d===e.length?i:n);a[u][d]=Math.max(p,g,m),a[u][d]===p?(s[d]=!1,l[d]=!1):a[u][d]===g?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=u,u=(u+1)%2}const h=Math.min(e.length,r.length);return(h-a[c][e.length])/h}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},9039:(e,t,n)=>{"use strict";var i;n.d(t,{c:()=>i}),function(e){e.UMAP="UMAP",e.T_SNE="t-SNE"}(i||(i={}))},8498:(e,t,n)=>{"use strict";var i,o,r,s,a,l,c;n.d(t,{EG:()=>a,Pn:()=>o,RR:()=>l,Wn:()=>c,aT:()=>r,m6:()=>s,xL:()=>i}),function(e){e.Levenshtein="Levenshtein",e.JaroWinkler="Jaro-Winkler",e.Manhattan="Manhattan String",e.Onehot="One-Hot"}(i||(i={})),function(e){e.Euclidean="Euclidean",e.Manhattan="Manhattan",e.Cosine="Vector Cosine"}(o||(o={})),function(e){e.Tanimoto="Tanimoto",e.Dice="Dice",e.Asymmetric="Asymmetric",e.BraunBlanquet="Braun-Blanquet",e.Cosine="Cosine",e.Kulczynski="Kulczynski",e.McConnaughey="Mc-Connaughey",e.RogotGoldberg="Rogot-Goldberg",e.Russel="Russel",e.Sokal="Sokal",e.Hamming="Hamming",e.Euclidean="Euclidean BitArray"}(r||(r={})),function(e){e.TanimotoIntArray="TanimotoIntArray"}(s||(s={})),function(e){e.Vector="Vector",e.String="String",e.BitArray="BitArray",e.MacroMolecule="MacroMolecule",e.Number="Number",e.IntArray="IntArray",e.NumberArray="NumberArray"}(a||(a={})),function(e){e.Difference="Difference"}(l||(l={})),function(e){e.CommonItems="Common Items"}(c||(c={}))},2780:(e,t,n)=>{"use strict";n(8498),n(9336)},9336:(e,t,n)=>{"use strict";var i=n(2787),o=n(944),r=n(6295),s=n(6863),a=n(8498);const l={[a.Pn.Euclidean]:r.jL,[a.Pn.Manhattan]:r.Hf,[a.Pn.Cosine]:r.w_},c={[a.xL.Levenshtein]:i.I,[a.xL.JaroWinkler]:o.Vb,[a.xL.Manhattan]:function(e,t){if(e.length!==t.length)return 1;{let n=0;for(let i=1;i<e.length;i++)n+=e[i]==t[i]?0:1;return n/e.length}},[a.xL.Onehot]:function(e,t){return e===t?0:1}},u={[a.aT.Tanimoto]:r.tO,[a.aT.Dice]:r.zn,[a.aT.Asymmetric]:r.gt,[a.aT.BraunBlanquet]:r.ij,[a.aT.Cosine]:r.lO,[a.aT.Kulczynski]:r.rR,[a.aT.McConnaughey]:r.lP,[a.aT.RogotGoldberg]:r.TK,[a.aT.Russel]:r.yK,[a.aT.Sokal]:r.Ii,[a.aT.Hamming]:r.be,[a.aT.Euclidean]:r.Qj},h={[a.m6.TanimotoIntArray]:r.v_},d={[a.RR.Difference]:r.T6},p={[a.Wn.CommonItems]:r.Hr},m={[a.EG.Vector]:{[a.Pn.Euclidean]:l[a.Pn.Euclidean],[a.Pn.Manhattan]:l[a.Pn.Manhattan],[a.Pn.Cosine]:l[a.Pn.Cosine]},[a.EG.String]:{[a.xL.Levenshtein]:c[a.xL.Levenshtein],[a.xL.JaroWinkler]:c[a.xL.JaroWinkler],[a.xL.Manhattan]:c[a.xL.Manhattan],[a.xL.Onehot]:c[a.xL.Onehot]},[a.EG.BitArray]:{[a.aT.Tanimoto]:u[a.aT.Tanimoto],[a.aT.Dice]:u[a.aT.Dice],[a.aT.Asymmetric]:u[a.aT.Asymmetric],[a.aT.BraunBlanquet]:u[a.aT.BraunBlanquet],[a.aT.Cosine]:u[a.aT.Cosine],[a.aT.Kulczynski]:u[a.aT.Kulczynski],[a.aT.McConnaughey]:u[a.aT.McConnaughey],[a.aT.RogotGoldberg]:u[a.aT.RogotGoldberg],[a.aT.Russel]:u[a.aT.Russel],[a.aT.Sokal]:u[a.aT.Sokal]},[a.EG.MacroMolecule]:{[s.Z.HAMMING]:s.V[s.Z.HAMMING],[s.Z.LEVENSHTEIN]:s.V[s.Z.LEVENSHTEIN],[s.Z.NEEDLEMANN_WUNSCH]:s.V[s.Z.NEEDLEMANN_WUNSCH],[s.Z.MONOMER_CHEMICAL_DISTANCE]:s.V[s.Z.MONOMER_CHEMICAL_DISTANCE]},[a.EG.Number]:{[a.RR.Difference]:d[a.RR.Difference]},[a.EG.IntArray]:{[a.m6.TanimotoIntArray]:h[a.m6.TanimotoIntArray]},[a.EG.NumberArray]:{[a.Wn.CommonItems]:p[a.Wn.CommonItems]}};Object.keys(m).reduce(((e,t)=>{for(const n of Object.keys(m[t]))e[n]=t;return e}),{})},8774:(e,t,n)=>{"use strict";n.d(t,{A:()=>i});class i{constructor(e,t=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof e){const n=e,o=i._createBuffer(n);if(t)for(let e=0;e<o.length;e++)o[e]=-1;this._data=o,this._length=n}else{if(!(e instanceof Uint32Array))throw new Error("Invalid constructor");this._data=e,this._length=t}}getRawData(){return this._data}assureGoez(e,t){if(e<0)throw new Error(`${t} should be greater than zero`)}assureInRange(e,t,n,i){if(e<t||e>n)throw new Error(`Argument ${i} (${e}) out of range (${t}, ${n})`)}copy(e,t,n){for(let i=0;i<n;i++)t[i]=e[i]}copyFrom(e){if(this._length!=e._length)throw new Error(`Lengths differ (${this._length} != ${e._length})`);this.copy(e._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(e){this._data=e,this._version++}get version(){return this._version}set version(e){this._version=e}incrementVersion(e=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(e){this._versionedName=e,this._versionedNameVersion=this._version}get self(){return this}setLength(e){if(e<0)throw new Error("should be >= 0");if(e==this._length)return;const t=Math.floor((e+31)/32);if(t>this._data.length||t+this.SHRINK_THRESHOLD<this._data.length){const e=new Uint32Array(t);this.copy(this._data,e,t>this._data.length?this._data.length:t),this._data=e}e>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,t)),this._length=e,this._version++}static fromAnd(e,t){if(e._length!=t._length)throw new Error(`Lengths differ (${e._length} != ${t._length})`);const n=new i(e._length);n._length=e._length,n._data=i._createBuffer(n._length),n._version=0;const o=e.lengthInInts;for(let i=0;i<o;i++)n._data[i]=e._data[i]&t._data[i];return n}static _createBuffer(e){return new Uint32Array(Math.floor((e+31)/32))}static fromValues(e){const t=new i(e.length);t._version=0;for(let n=0;n<t._length;n++)e[n]&&(t._data[Math.floor(n/32)]|=1<<(n%32&31));return t}static fromSeq(e,t){const n=new i(e);for(let i=0;i<e;++i)n.setBit(i,t(i));return n._version=0,n}static fromString(e){return i.fromSeq(e.length,(t=>"1"==e.charAt(t)))}static fromUint32Array(e,t){const n=new i(e);return n._data=t,n}static fromBytes(e){const t=e.length,n=new i(8*t);n._data=new Uint32Array(Math.floor((t+3)/4)),n._length=8*t;let o=0,r=0;for(;t-r>=4;)n._data[o++]=255&e[r]|(255&e[r+1])<<8|(255&e[r+2])<<16|(255&e[r+3])<<24,r+=4;return t-r==3&&(n._data[o]=(255&e[r+2])<<16),t-r==2&&(n._data[o]|=(255&e[r+1])<<8),t-r==1&&(n._data[o]|=255&e[r]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(e){if(this==e)return!0;if(null==e)return!1;if(this._length!=e._length)return!1;if(0==this._length)return!0;for(let t=0;t<this._data.length-1;t++)if(this._data[t]!=e._data[t])return!1;for(let t=8*(this._data.length-1);t<this._length;t++)if(this.getBit(t)!=e.getBit(t))return!1;return!0}clone(){const e=new i(0,!1);return e._data=Uint32Array.from(this._data),e._length=this._length,e._version=this._version,e}init(e,t){this.setAll(!1,!1);for(let t=0;t<this._length;t++)e(t)&&(this._data[Math.floor(t/32)]|=1<<(t%32&31));return this.incrementVersion(t),this}invert(e=!0){for(let e=0;e<this._data.length;e++)this._data[e]^=-1;this.incrementVersion(e)}setAll(e,t=!1){const n=e?-1:0,i=this.lengthInInts;for(let e=0;e<i;e++)this._data[e]=n;this.incrementVersion(t)}setIndexes(e,t=!0,n=!0,i=!0){n&&this.setAll(!t,!1);for(const n of e)this.setFast(n,t);this.incrementVersion(i)}everyIndex(e,t=!0){for(const n of e)if(this.getBit(n)!=t)return!1;return!0}anyIndex(e,t=!0){for(const n of e)if(this.getBit(n)==t)return!0;return!1}setWhere(e,t=!0,n=!0,i=!0,o=!0){if(n&&o&&this.setAll(!t,!1),o)for(let n=0;n<this._length;n++)e(n)&&this.setFast(n,t);else for(let n=0;n<this._length;n++)this.setFast(n,e(n)?t:!t);this.incrementVersion(i)}getRange(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let i=e;i<t;++i)n.push(this.getBit(i));return i.fromValues(n)}getRangeAsList(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let i=e;i<t;++i)n.push(this.getBit(i));return n}setRange(e,t,n,i=!0){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length-1,"to");const o=Math.min(e,t),r=Math.max(e,t);if(n)for(let e=o;e<=r;e++)this.setTrue(e);else for(let e=o;e<=r;e++)this.setFalse(e);return this.incrementVersion(i),this}setRandom(e,t,n=!0){if(e<0||e>this._length)throw new Error("n must be >= 0 && <= Count");e>this._length/2&&this.setRandom(this._length-e,!t),this.setAll(!t);for(let n=0;n<e;){const e=Math.floor(Math.random()*this._length);this.getBit(e)!=t&&(this.setFast(e,t),n++)}this.incrementVersion(n)}and(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]&=e._data[t];return this.incrementVersion(t),this}andNot(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]&=~e._data[t];return this.incrementVersion(t),this}notAnd(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]=~this._data[t]&e._data[t];return this.incrementVersion(t),this}not(e=!0){for(let e=0,t=this.lengthInInts;e<t;e++)this._data[e]=~this._data[e];return this.incrementVersion(e),this}or(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]|=e._data[t];return this.incrementVersion(t),this}xor(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]^=e._data[t];return this.incrementVersion(t),this}insertAt(e,t,n=!1){if(this.assureInRange(e,0,this._length,"pos"),0==t)return;const i=this._length;this.setLength(this._length+t);for(let n=i-1;n>=e;n--)this.setBit(n+t,this.getBit(n));for(let i=e;i<e+t;i++)this.setBit(i,n)}removeAt(e,t=1){if(t<0)throw new Error("n cannot be negative");if(this.assureInRange(e,0,this._length-t,"pos"),this.contains(!0))for(let n=e;n<this._length-t;n++)this.setBit(n,this.getBit(n+t));this.setLength(this._length-t)}removeByMask(e,t=!0){if(this._length!=e.length)throw new Error("length != mask.length");if(e==this)this.setLength(e.countBits(!t)),this.setAll(!t);else{let n=0;for(let i=-1;-1!=(i=e.findNext(i,!t));)this.setFast(n++,this.getBit(i));this._length=n,this._version++}return this}getBit(e){return!!(this._data[Math.floor(e/32)]&1<<(31&e))}setBit(e,t,n=!0){this.setFast(e,t),this._version++}setFast(e,t){t?this._data[Math.floor(e/32)]|=1<<(31&e):this._data[Math.floor(e/32)]&=~(1<<(31&e))}setTrue(e){this._data[Math.floor(e/32)]|=1<<(31&e)}setFalse(e){this._data[Math.floor(e/32)]&=~(1<<(31&e))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(e){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const e=this.lengthInInts;let t=0;for(;t<e-1;t++)for(let e=this._data[t];0!=e;e>>>=8)this._selectedCount+=i._onBitCount[255&e];let n=this._data[t];const o=31&this._length;for(0!=o&&(n&=~(4294967295<<o));0!=n;n>>>=8)this._selectedCount+=i._onBitCount[255&n];this._selectedCountVersion=this._version}return e?this._selectedCount:this._length-this._selectedCount}countWhere(e){let t=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)t+=e(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)t+=e(n)?1:0;return t}andWithCountBits(e,t){if(0==this._length)return 0;let n=0;const o=this.lengthInInts;let r=0;for(;r<o-1;r++)for(let t=this._data[r]&e._data[r];0!=t;t>>>=8)n+=i._onBitCount[255&t];let s=this._data[r]&e._data[r];const a=31&this._length;for(0!=a&&(s&=~(4294967295<<a));0!=s;s>>>=8)n+=i._onBitCount[255&s];return t?n:this._length-n}clear(){this.setLength(0)}contains(e){return this.findNext(-1,e)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(e,t=!0){if(this.assureInRange(e,-1,this._length,"index"),e>=this._length-1)return-1;let n=31&(e=e<0?0:e+1);const o=this.lengthInInts;for(let r=Math.floor(e/32);r<o;r++){let o=t?this._data[r]:~this._data[r];if(0!=n)o&=4294967295<<n&4294967295,n=0;else if(!t&&-4294967296==o)continue;for(let t=0;0!=o;t+=8,o>>>=8){const n=i._firstOnBit[255&o];if(n>=0)return(e=n+32*r+t)>=this._length?-1:e}}return-1}findPrev(e,t=!0){if(0==e)return-1;this.assureInRange(e,-1,this._length,"index");let n=1+(e=e<0?this._length-1:e-1)&31;for(let o=Math.floor(e/32);o>=0;o--){let e=t?this._data[o]:~this._data[o];0!=n&&(e&=~(4294967295<<n),n=0);for(let t=24;0!=e;t-=8,e<<=8){const n=i._lastOnBit[e>>>24];if(n>=0)return n+32*o+t}}return-1}}i._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),i._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),i._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(e,t,n)=>{"use strict";n.d(t,{cb:()=>a,PE:()=>s}),n(4328);var i=n(6082);n(9982),i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var o,r=function(e,t,n,i){return new(n||(n=Promise))((function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function s(e,t,n,i=0,o="timeout"){return r(this,void 0,void 0,(function*(){return new Promise(((r,s)=>{const a=e.subscribe((e=>{try{t(e),r("OK")}catch(e){s(e)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),s(o)}),i);n()}))}))}function a(e){return r(this,void 0,void 0,(function*(){yield new Promise((t=>setTimeout(t,e)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(e){e.notNull=function(e,t){if(null==e)throw new Error(`${null==t?"Value":t} not defined`)}}(o||(o={})),i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])])},3527:(e,t,n)=>{"use strict";n.d(t,{Mi:()=>i});class i extends Float32Array{}},3629:(e,t,n)=>{"use strict";n.d(t,{KE:()=>a,S8:()=>l,dC:()=>r,vA:()=>o,wQ:()=>s});var i=n(3527);function o(e=!1,t="Assertion error."){if(!e)throw new Error(t)}function r(e,t,n=1){const r=e.length;o(r==t.length,"Vector lengths do not match.");const s=new i.Mi(r);for(let i=0;i<e.length;++i)s[i]=e[i]+n*t[i];return s}function s(e){let t=0;for(let n=0;n<e.length;n++)t+=e[n]*e[n];return Math.sqrt(t)}function a(e,t){if(e.length!=t.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}function l(e){const t=e.length;let n=0,i=0;for(let o=0;o<t;++o)n+=e[o],i+=Math.pow(e[o],2);const o=n/t,r=1/Math.sqrt(i/t-Math.pow(o,2));for(let n=0;n<t;++n)e[n]=(e[n]-o)*r;return e}},1913:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3282),o=n(9029),r=n(1520),s=n(2586),a=n(8708),l=n(2023),c="errorMessage",u=new i.Name("emUsed"),h={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const g=(e,t={})=>{if(!e.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(e.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return e.addKeyword(function(e){return{keyword:c,schemaType:["string","object"],post:!0,code(t){const{gen:n,data:g,schema:f,schemaValue:y,it:b}=t;if(!1===b.createErrors)return;const v=f,w=o.strConcat(l.default.instancePath,b.errorPath);function C(e,t){return o.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,i._`${e}.instancePath === ${w}`,i._`${e}.keyword in ${t}`,i._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`/^\\/[^\\/]*$/.test(${e}.schemaPath.slice(${b.errSchemaPath.length}))`)}function S(e,t){const i=[];for(const n in e){const e=t[n];d.test(e)&&i.push([n,x(e)])}return n.object(...i)}function A(e){return d.test(e)?new r._Code(r.safeStringify(e).replace(p,((e,t)=>`" + JSON.stringify(${s.getData(t,b)}) + "`)).replace(m,"")):i.stringify(e)}function x(e){return i._`function(){return ${A(e)}}`}n.if(i._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[r,s]=function(e){let t,n;for(const i in e){if("properties"===i||"items"===i)continue;const o=e[i];if("object"==typeof o){t||(t={});const e=t[i]={};for(const t in o)e[t]=[]}else n||(n={}),n[i]=[]}return[t,n]}(v);s&&function(o){const r=n.const("emErrors",i.stringify(o)),s=n.const("templates",S(o,f));n.forOf("err",l.default.vErrors,(e=>n.if(C(e,r),(()=>n.code(i._`${r}[${e}.keyword].push(${e})`).assign(i._`${e}.${u}`,!0)))));const{singleError:c}=e;if(c){const e=n.let("message",i._`""`),o=n.let("paramsErrors",i._`[]`);h((t=>{n.if(e,(()=>n.code(i._`${e} += ${"string"==typeof c?c:";"}`))),n.code(i._`${e} += ${d(t)}`),n.assign(o,i._`${o}.concat(${r}[${t}])`)})),a.reportError(t,{message:e,params:i._`{errors: ${o}}`})}else h((e=>a.reportError(t,{message:d(e),params:i._`{errors: ${r}[${e}]}`})));function h(e){n.forIn("key",r,(t=>n.if(i._`${r}[${t}].length`,(()=>e(t)))))}function d(e){return i._`${e} in ${s} ? ${s}[${e}]() : ${y}[${e}]`}}(s),r&&function(e){const o=n.const("emErrors",i.stringify(e)),r=[];for(const t in e)r.push([t,S(e[t],f[t])]);const s=n.const("templates",n.object(...r)),c=n.scopeValue("obj",{ref:h,code:i.stringify(h)}),d=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(e=>n.if(C(e,o),(()=>{n.assign(d,i._`${c}[${e}.keyword]`),n.assign(p,i._`${o}[${e}.keyword][${e}.params[${d}]]`),n.if(p,(()=>n.code(i._`${p}.push(${e})`).assign(i._`${e}.${u}`,!0)))})))),n.forIn("key",o,(e=>n.forIn("keyProp",i._`${o}[${e}]`,(r=>{n.assign(p,i._`${o}[${e}][${r}]`),n.if(i._`${p}.length`,(()=>{const o=n.const("tmpl",i._`${s}[${e}] && ${s}[${e}][${r}]`);a.reportError(t,{message:i._`${o} ? ${o}() : ${y}[${e}][${r}]`,params:i._`{errors: ${p}}`})}))}))))}(r),function(e){const{props:r,items:s}=e;if(!r&&!s)return;const h=i._`typeof ${g} == "object"`,d=i._`Array.isArray(${g})`,p=n.let("emErrors");let m,b;const v=n.let("templates");function C(e,t){n.assign(p,i.stringify(e)),n.assign(v,S(e,t))}r&&s?(m=n.let("emChildKwd"),n.if(h),n.if(d,(()=>{C(s,f.items),n.assign(m,i.str`items`)}),(()=>{C(r,f.properties),n.assign(m,i.str`properties`)})),b=i._`[${m}]`):s?(n.if(d),C(s,f.items),b=i._`.items`):r&&(n.if(o.and(h,o.not(d))),C(r,f.properties),b=i._`.properties`),n.forOf("err",l.default.vErrors,(e=>function(e,t,r){n.if(o.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,i._`${e}.instancePath.indexOf(${w}) === 0`),(()=>{const o=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:i._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),s=n.const("emMatches",i._`${o}.exec(${e}.instancePath.slice(${w}.length))`),a=n.const("emChild",i._`${s} && ${s}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(i._`${a} !== undefined && ${a} in ${t}`,(()=>r(a)))}))}(e,p,(t=>n.code(i._`${p}[${t}].push(${e})`).assign(i._`${e}.${u}`,!0))))),n.forIn("key",p,(e=>n.if(i._`${p}[${e}].length`,(()=>{a.reportError(t,{message:i._`${e} in ${v} ? ${v}[${e}]() : ${y}${b}[${e}]`,params:i._`{errors: ${p}[${e}]}`}),n.assign(i._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,i._`${w} + "/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:e,items:t}){const n={};if(e){n.props={};for(const t in e)n.props[t]=[]}if(t){n.items={};for(let e=0;e<t.length;e++)n.items[e]=[]}return n}(v))}const r="string"==typeof v?v:v._;r&&function(e){const r=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(function(e){return o.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,o.or(i._`${e}.instancePath === ${w}`,o.and(i._`${e}.instancePath.indexOf(${w}) === 0`,i._`${e}.instancePath[${w}.length] === "/"`)),i._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`${e}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(e),(()=>n.code(i._`${r}.push(${e})`).assign(i._`${e}.${u}`,!0))))),n.if(i._`${r}.length`,(()=>a.reportError(t,{message:A(e),params:i._`{errors: ${r}}`})))}(r),e.keepErrors||function(){const e=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(i._`!${t}.${u}`,(()=>n.code(i._`${e}.push(${t})`))))),n.assign(l.default.vErrors,e).assign(l.default.errors,i._`${e}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(t))};t.default=g,e.exports=g,e.exports.default=g},7433:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv2020=void 0;const i=n(4042),o=n(6105),r=n(6653),s=n(9572),a="https://json-schema.org/draft/2020-12/schema";class l extends i.default{constructor(e={}){super({...e,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),o.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(r.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:e,meta:t}=this.opts;t&&(s.default.call(this,e),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}t.Ajv2020=l,e.exports=t=l,e.exports.Ajv2020=l,Object.defineProperty(t,"__esModule",{value:!0}),t.default=l;var c=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var u=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var h=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return h.default}});var d=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},3282:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv=void 0;const i=n(4042),o=n(6144),r=n(6653),s=n(2079),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends i.default{_addVocabularies(){super._addVocabularies(),o.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(r.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const e=this.opts.$data?this.$dataMetaSchema(s,a):s;this.addMetaSchema(e,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}t.Ajv=c,e.exports=t=c,e.exports.Ajv=c,Object.defineProperty(t,"__esModule",{value:!0}),t.default=c;var u=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return u.KeywordCxt}});var h=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var d=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return d.default}});var p=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.regexpCode=t.getEsmExportName=t.getProperty=t.safeStringify=t.stringify=t.strConcat=t.addCodeArg=t.str=t._=t.nil=t._Code=t.Name=t.IDENTIFIER=t._CodeOrName=void 0;class n{}t._CodeOrName=n,t.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class i extends n{constructor(e){if(super(),!t.IDENTIFIER.test(e))throw new Error("CodeGen: name must be a valid identifier");this.str=e}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}t.Name=i;class o extends n{constructor(e){super(),this._items="string"==typeof e?[e]:e}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const e=this._items[0];return""===e||'""'===e}get str(){var e;return null!==(e=this._str)&&void 0!==e?e:this._str=this._items.reduce(((e,t)=>`${e}${t}`),"")}get names(){var e;return null!==(e=this._names)&&void 0!==e?e:this._names=this._items.reduce(((e,t)=>(t instanceof i&&(e[t.str]=(e[t.str]||0)+1),e)),{})}}function r(e,...t){const n=[e[0]];let i=0;for(;i<t.length;)l(n,t[i]),n.push(e[++i]);return new o(n)}t._Code=o,t.nil=new o(""),t._=r;const s=new o("+");function a(e,...t){const n=[u(e[0])];let i=0;for(;i<t.length;)n.push(s),l(n,t[i]),n.push(s,u(e[++i]));return function(e){let t=1;for(;t<e.length-1;){if(e[t]===s){const n=c(e[t-1],e[t+1]);if(void 0!==n){e.splice(t-1,3,n);continue}e[t++]="+"}t++}}(n),new o(n)}function l(e,t){var n;t instanceof o?e.push(...t._items):t instanceof i?e.push(t):e.push("number"==typeof(n=t)||"boolean"==typeof n||null===n?n:u(Array.isArray(n)?n.join(","):n))}function c(e,t){if('""'===t)return e;if('""'===e)return t;if("string"==typeof e){if(t instanceof i||'"'!==e[e.length-1])return;return"string"!=typeof t?`${e.slice(0,-1)}${t}"`:'"'===t[0]?e.slice(0,-1)+t.slice(1):void 0}return"string"!=typeof t||'"'!==t[0]||e instanceof i?void 0:`"${e}${t.slice(1)}`}function u(e){return JSON.stringify(e).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}t.str=a,t.addCodeArg=l,t.strConcat=function(e,t){return t.emptyStr()?e:e.emptyStr()?t:a`${e}${t}`},t.stringify=function(e){return new o(u(e))},t.safeStringify=u,t.getProperty=function(e){return"string"==typeof e&&t.IDENTIFIER.test(e)?new o(`.${e}`):r`[${e}]`},t.getEsmExportName=function(e){if("string"==typeof e&&t.IDENTIFIER.test(e))return new o(`${e}`);throw new Error(`CodeGen: invalid export name: ${e}, use explicit $id name mapping`)},t.regexpCode=function(e){return new o(e.toString())}},9029:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.or=t.and=t.not=t.CodeGen=t.operators=t.varKinds=t.ValueScopeName=t.ValueScope=t.Scope=t.Name=t.regexpCode=t.stringify=t.getProperty=t.nil=t.strConcat=t.str=t._=void 0;const i=n(1520),o=n(7845);var r=n(1520);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return r._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return r.str}}),Object.defineProperty(t,"strConcat",{enumerable:!0,get:function(){return r.strConcat}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return r.nil}}),Object.defineProperty(t,"getProperty",{enumerable:!0,get:function(){return r.getProperty}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return r.stringify}}),Object.defineProperty(t,"regexpCode",{enumerable:!0,get:function(){return r.regexpCode}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return r.Name}});var s=n(7845);Object.defineProperty(t,"Scope",{enumerable:!0,get:function(){return s.Scope}}),Object.defineProperty(t,"ValueScope",{enumerable:!0,get:function(){return s.ValueScope}}),Object.defineProperty(t,"ValueScopeName",{enumerable:!0,get:function(){return s.ValueScopeName}}),Object.defineProperty(t,"varKinds",{enumerable:!0,get:function(){return s.varKinds}}),t.operators={GT:new i._Code(">"),GTE:new i._Code(">="),LT:new i._Code("<"),LTE:new i._Code("<="),EQ:new i._Code("==="),NEQ:new i._Code("!=="),NOT:new i._Code("!"),OR:new i._Code("||"),AND:new i._Code("&&"),ADD:new i._Code("+")};class a{optimizeNodes(){return this}optimizeNames(e,t){return this}}class l extends a{constructor(e,t,n){super(),this.varKind=e,this.name=t,this.rhs=n}render({es5:e,_n:t}){const n=e?o.varKinds.var:this.varKind,i=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${i};`+t}optimizeNames(e,t){if(e[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,e,t)),this}get names(){return this.rhs instanceof i._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(e,t,n){super(),this.lhs=e,this.rhs=t,this.sideEffects=n}render({_n:e}){return`${this.lhs} = ${this.rhs};`+e}optimizeNames(e,t){if(!(this.lhs instanceof i.Name)||e[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,e,t),this}get names(){return L(this.lhs instanceof i.Name?{}:{...this.lhs.names},this.rhs)}}class u extends c{constructor(e,t,n,i){super(e,n,i),this.op=t}render({_n:e}){return`${this.lhs} ${this.op}= ${this.rhs};`+e}}class h extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`${this.label}:`+e}}class d extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`break${this.label?` ${this.label}`:""};`+e}}class p extends a{constructor(e){super(),this.error=e}render({_n:e}){return`throw ${this.error};`+e}get names(){return this.error.names}}class m extends a{constructor(e){super(),this.code=e}render({_n:e}){return`${this.code};`+e}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(e,t){return this.code=N(this.code,e,t),this}get names(){return this.code instanceof i._CodeOrName?this.code.names:{}}}class g extends a{constructor(e=[]){super(),this.nodes=e}render(e){return this.nodes.reduce(((t,n)=>t+n.render(e)),"")}optimizeNodes(){const{nodes:e}=this;let t=e.length;for(;t--;){const n=e[t].optimizeNodes();Array.isArray(n)?e.splice(t,1,...n):n?e[t]=n:e.splice(t,1)}return e.length>0?this:void 0}optimizeNames(e,t){const{nodes:n}=this;let i=n.length;for(;i--;){const o=n[i];o.optimizeNames(e,t)||(P(e,o.names),n.splice(i,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((e,t)=>I(e,t.names)),{})}}class f extends g{render(e){return"{"+e._n+super.render(e)+"}"+e._n}}class y extends g{}class b extends f{}b.kind="else";class v extends f{constructor(e,t){super(t),this.condition=e}render(e){let t=`if(${this.condition})`+super.render(e);return this.else&&(t+="else "+this.else.render(e)),t}optimizeNodes(){super.optimizeNodes();const e=this.condition;if(!0===e)return this.nodes;let t=this.else;if(t){const e=t.optimizeNodes();t=this.else=Array.isArray(e)?new b(e):e}return t?!1===e?t instanceof v?t:t.nodes:this.nodes.length?this:new v(R(e),t instanceof v?[t]:t.nodes):!1!==e&&this.nodes.length?this:void 0}optimizeNames(e,t){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(e,t),super.optimizeNames(e,t)||this.else)return this.condition=N(this.condition,e,t),this}get names(){const e=super.names;return L(e,this.condition),this.else&&I(e,this.else.names),e}}v.kind="if";class w extends f{}w.kind="for";class C extends w{constructor(e){super(),this.iteration=e}render(e){return`for(${this.iteration})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iteration=N(this.iteration,e,t),this}get names(){return I(super.names,this.iteration.names)}}class S extends w{constructor(e,t,n,i){super(),this.varKind=e,this.name=t,this.from=n,this.to=i}render(e){const t=e.es5?o.varKinds.var:this.varKind,{name:n,from:i,to:r}=this;return`for(${t} ${n}=${i}; ${n}<${r}; ${n}++)`+super.render(e)}get names(){const e=L(super.names,this.from);return L(e,this.to)}}class A extends w{constructor(e,t,n,i){super(),this.loop=e,this.varKind=t,this.name=n,this.iterable=i}render(e){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iterable=N(this.iterable,e,t),this}get names(){return I(super.names,this.iterable.names)}}class x extends f{constructor(e,t,n){super(),this.name=e,this.args=t,this.async=n}render(e){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(e)}}x.kind="func";class M extends g{render(e){return"return "+super.render(e)}}M.kind="return";class E extends f{render(e){let t="try"+super.render(e);return this.catch&&(t+=this.catch.render(e)),this.finally&&(t+=this.finally.render(e)),t}optimizeNodes(){var e,t;return super.optimizeNodes(),null===(e=this.catch)||void 0===e||e.optimizeNodes(),null===(t=this.finally)||void 0===t||t.optimizeNodes(),this}optimizeNames(e,t){var n,i;return super.optimizeNames(e,t),null===(n=this.catch)||void 0===n||n.optimizeNames(e,t),null===(i=this.finally)||void 0===i||i.optimizeNames(e,t),this}get names(){const e=super.names;return this.catch&&I(e,this.catch.names),this.finally&&I(e,this.finally.names),e}}class T extends f{constructor(e){super(),this.error=e}render(e){return`catch(${this.error})`+super.render(e)}}T.kind="catch";class _ extends f{render(e){return"finally"+super.render(e)}}function I(e,t){for(const n in t)e[n]=(e[n]||0)+(t[n]||0);return e}function L(e,t){return t instanceof i._CodeOrName?I(e,t.names):e}function N(e,t,n){return e instanceof i.Name?r(e):(o=e)instanceof i._Code&&o._items.some((e=>e instanceof i.Name&&1===t[e.str]&&void 0!==n[e.str]))?new i._Code(e._items.reduce(((e,t)=>(t instanceof i.Name&&(t=r(t)),t instanceof i._Code?e.push(...t._items):e.push(t),e)),[])):e;var o;function r(e){const i=n[e.str];return void 0===i||1!==t[e.str]?e:(delete t[e.str],i)}}function P(e,t){for(const n in t)e[n]=(e[n]||0)-(t[n]||0)}function R(e){return"boolean"==typeof e||"number"==typeof e||null===e?!e:i._`!${H(e)}`}_.kind="finally",t.CodeGen=class{constructor(e,t={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...t,_n:t.lines?"\n":""},this._extScope=e,this._scope=new o.Scope({parent:e}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(e){return this._scope.name(e)}scopeName(e){return this._extScope.name(e)}scopeValue(e,t){const n=this._extScope.value(e,t);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(e,t){return this._extScope.getValue(e,t)}scopeRefs(e){return this._extScope.scopeRefs(e,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(e,t,n,i){const o=this._scope.toName(t);return void 0!==n&&i&&(this._constants[o.str]=n),this._leafNode(new l(e,o,n)),o}const(e,t,n){return this._def(o.varKinds.const,e,t,n)}let(e,t,n){return this._def(o.varKinds.let,e,t,n)}var(e,t,n){return this._def(o.varKinds.var,e,t,n)}assign(e,t,n){return this._leafNode(new c(e,t,n))}add(e,n){return this._leafNode(new u(e,t.operators.ADD,n))}code(e){return"function"==typeof e?e():e!==i.nil&&this._leafNode(new m(e)),this}object(...e){const t=["{"];for(const[n,o]of e)t.length>1&&t.push(","),t.push(n),(n!==o||this.opts.es5)&&(t.push(":"),(0,i.addCodeArg)(t,o));return t.push("}"),new i._Code(t)}if(e,t,n){if(this._blockNode(new v(e)),t&&n)this.code(t).else().code(n).endIf();else if(t)this.code(t).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(e){return this._elseNode(new v(e))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(e,t){return this._blockNode(e),t&&this.code(t).endFor(),this}for(e,t){return this._for(new C(e),t)}forRange(e,t,n,i,r=(this.opts.es5?o.varKinds.var:o.varKinds.let)){const s=this._scope.toName(e);return this._for(new S(r,s,t,n),(()=>i(s)))}forOf(e,t,n,r=o.varKinds.const){const s=this._scope.toName(e);if(this.opts.es5){const e=t instanceof i.Name?t:this.var("_arr",t);return this.forRange("_i",0,i._`${e}.length`,(t=>{this.var(s,i._`${e}[${t}]`),n(s)}))}return this._for(new A("of",r,s,t),(()=>n(s)))}forIn(e,t,n,r=(this.opts.es5?o.varKinds.var:o.varKinds.const)){if(this.opts.ownProperties)return this.forOf(e,i._`Object.keys(${t})`,n);const s=this._scope.toName(e);return this._for(new A("in",r,s,t),(()=>n(s)))}endFor(){return this._endBlockNode(w)}label(e){return this._leafNode(new h(e))}break(e){return this._leafNode(new d(e))}return(e){const t=new M;if(this._blockNode(t),this.code(e),1!==t.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(M)}try(e,t,n){if(!t&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const i=new E;if(this._blockNode(i),this.code(e),t){const e=this.name("e");this._currNode=i.catch=new T(e),t(e)}return n&&(this._currNode=i.finally=new _,this.code(n)),this._endBlockNode(T,_)}throw(e){return this._leafNode(new p(e))}block(e,t){return this._blockStarts.push(this._nodes.length),e&&this.code(e).endBlock(t),this}endBlock(e){const t=this._blockStarts.pop();if(void 0===t)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-t;if(n<0||void 0!==e&&n!==e)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${e} expected`);return this._nodes.length=t,this}func(e,t=i.nil,n,o){return this._blockNode(new x(e,t,n)),o&&this.code(o).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(e=1){for(;e-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(e){return this._currNode.nodes.push(e),this}_blockNode(e){this._currNode.nodes.push(e),this._nodes.push(e)}_endBlockNode(e,t){const n=this._currNode;if(n instanceof e||t&&n instanceof t)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${t?`${e.kind}/${t.kind}`:e.kind}"`)}_elseNode(e){const t=this._currNode;if(!(t instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=t.else=e,this}get _root(){return this._nodes[0]}get _currNode(){const e=this._nodes;return e[e.length-1]}set _currNode(e){const t=this._nodes;t[t.length-1]=e}},t.not=R;const $=k(t.operators.AND);t.and=function(...e){return e.reduce($)};const O=k(t.operators.OR);function k(e){return(t,n)=>t===i.nil?n:n===i.nil?t:i._`${H(t)} ${e} ${H(n)}`}function H(e){return e instanceof i.Name?e:i._`(${e})`}t.or=function(...e){return e.reduce(O)}},7845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ValueScope=t.ValueScopeName=t.Scope=t.varKinds=t.UsedValueState=void 0;const i=n(1520);class o extends Error{constructor(e){super(`CodeGen: "code" for ${e} not defined`),this.value=e.value}}var r;!function(e){e[e.Started=0]="Started",e[e.Completed=1]="Completed"}(r||(t.UsedValueState=r={})),t.varKinds={const:new i.Name("const"),let:new i.Name("let"),var:new i.Name("var")};class s{constructor({prefixes:e,parent:t}={}){this._names={},this._prefixes=e,this._parent=t}toName(e){return e instanceof i.Name?e:this.name(e)}name(e){return new i.Name(this._newName(e))}_newName(e){return`${e}${(this._names[e]||this._nameGroup(e)).index++}`}_nameGroup(e){var t,n;if((null===(n=null===(t=this._parent)||void 0===t?void 0:t._prefixes)||void 0===n?void 0:n.has(e))||this._prefixes&&!this._prefixes.has(e))throw new Error(`CodeGen: prefix "${e}" is not allowed in this scope`);return this._names[e]={prefix:e,index:0}}}t.Scope=s;class a extends i.Name{constructor(e,t){super(t),this.prefix=e}setValue(e,{property:t,itemIndex:n}){this.value=e,this.scopePath=i._`.${new i.Name(t)}[${n}]`}}t.ValueScopeName=a;const l=i._`\n`;t.ValueScope=class extends s{constructor(e){super(e),this._values={},this._scope=e.scope,this.opts={...e,_n:e.lines?l:i.nil}}get(){return this._scope}name(e){return new a(e,this._newName(e))}value(e,t){var n;if(void 0===t.ref)throw new Error("CodeGen: ref must be passed in value");const i=this.toName(e),{prefix:o}=i,r=null!==(n=t.key)&&void 0!==n?n:t.ref;let s=this._values[o];if(s){const e=s.get(r);if(e)return e}else s=this._values[o]=new Map;s.set(r,i);const a=this._scope[o]||(this._scope[o]=[]),l=a.length;return a[l]=t.ref,i.setValue(t,{property:o,itemIndex:l}),i}getValue(e,t){const n=this._values[e];if(n)return n.get(t)}scopeRefs(e,t=this._values){return this._reduceValues(t,(t=>{if(void 0===t.scopePath)throw new Error(`CodeGen: name "${t}" has no value`);return i._`${e}${t.scopePath}`}))}scopeCode(e=this._values,t,n){return this._reduceValues(e,(e=>{if(void 0===e.value)throw new Error(`CodeGen: name "${e}" has no value`);return e.value.code}),t,n)}_reduceValues(e,n,s={},a){let l=i.nil;for(const c in e){const u=e[c];if(!u)continue;const h=s[c]=s[c]||new Map;u.forEach((e=>{if(h.has(e))return;h.set(e,r.Started);let s=n(e);if(s){const n=this.opts.es5?t.varKinds.var:t.varKinds.const;l=i._`${l}${n} ${e} = ${s};${this.opts._n}`}else{if(!(s=null==a?void 0:a(e)))throw new o(e);l=i._`${l}${s}${this.opts._n}`}h.set(e,r.Completed)}))}return l}}},8708:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendErrors=t.resetErrorsCount=t.reportExtraError=t.reportError=t.keyword$DataError=t.keywordError=void 0;const i=n(9029),o=n(4227),r=n(2023);function s(e,t){const n=e.const("err",t);e.if(i._`${r.default.vErrors} === null`,(()=>e.assign(r.default.vErrors,i._`[${n}]`)),i._`${r.default.vErrors}.push(${n})`),e.code(i._`${r.default.errors}++`)}function a(e,t){const{gen:n,validateName:o,schemaEnv:r}=e;r.$async?n.throw(i._`new ${e.ValidationError}(${t})`):(n.assign(i._`${o}.errors`,t),n.return(!1))}t.keywordError={message:({keyword:e})=>i.str`must pass "${e}" keyword validation`},t.keyword$DataError={message:({keyword:e,schemaType:t})=>t?i.str`"${e}" keyword must be ${t} ($data)`:i.str`"${e}" keyword is invalid ($data)`},t.reportError=function(e,n=t.keywordError,o,r){const{it:l}=e,{gen:u,compositeRule:h,allErrors:d}=l,p=c(e,n,o);(null!=r?r:h||d)?s(u,p):a(l,i._`[${p}]`)},t.reportExtraError=function(e,n=t.keywordError,i){const{it:o}=e,{gen:l,compositeRule:u,allErrors:h}=o;s(l,c(e,n,i)),u||h||a(o,r.default.vErrors)},t.resetErrorsCount=function(e,t){e.assign(r.default.errors,t),e.if(i._`${r.default.vErrors} !== null`,(()=>e.if(t,(()=>e.assign(i._`${r.default.vErrors}.length`,t)),(()=>e.assign(r.default.vErrors,null)))))},t.extendErrors=function({gen:e,keyword:t,schemaValue:n,data:o,errsCount:s,it:a}){if(void 0===s)throw new Error("ajv implementation error");const l=e.name("err");e.forRange("i",s,r.default.errors,(s=>{e.const(l,i._`${r.default.vErrors}[${s}]`),e.if(i._`${l}.instancePath === undefined`,(()=>e.assign(i._`${l}.instancePath`,(0,i.strConcat)(r.default.instancePath,a.errorPath)))),e.assign(i._`${l}.schemaPath`,i.str`${a.errSchemaPath}/${t}`),a.opts.verbose&&(e.assign(i._`${l}.schema`,n),e.assign(i._`${l}.data`,o))}))};const l={keyword:new i.Name("keyword"),schemaPath:new i.Name("schemaPath"),params:new i.Name("params"),propertyName:new i.Name("propertyName"),message:new i.Name("message"),schema:new i.Name("schema"),parentSchema:new i.Name("parentSchema")};function c(e,t,n){const{createErrors:o}=e.it;return!1===o?i._`{}`:function(e,t,n={}){const{gen:o,it:s}=e,a=[u(s,n),h(e,n)];return function(e,{params:t,message:n},o){const{keyword:s,data:a,schemaValue:c,it:u}=e,{opts:h,propertyName:d,topSchemaRef:p,schemaPath:m}=u;o.push([l.keyword,s],[l.params,"function"==typeof t?t(e):t||i._`{}`]),h.messages&&o.push([l.message,"function"==typeof n?n(e):n]),h.verbose&&o.push([l.schema,c],[l.parentSchema,i._`${p}${m}`],[r.default.data,a]),d&&o.push([l.propertyName,d])}(e,t,a),o.object(...a)}(e,t,n)}function u({errorPath:e},{instancePath:t}){const n=t?i.str`${e}${(0,o.getErrorPath)(t,o.Type.Str)}`:e;return[r.default.instancePath,(0,i.strConcat)(r.default.instancePath,n)]}function h({keyword:e,it:{errSchemaPath:t}},{schemaPath:n,parentSchema:r}){let s=r?t:i.str`${t}/${e}`;return n&&(s=i.str`${s}${(0,o.getErrorPath)(n,o.Type.Str)}`),[l.schemaPath,s]}},3835:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.resolveSchema=t.getCompilingSchema=t.resolveRef=t.compileSchema=t.SchemaEnv=void 0;const i=n(9029),o=n(3558),r=n(2023),s=n(6939),a=n(4227),l=n(2586);class c{constructor(e){var t;let n;this.refs={},this.dynamicAnchors={},"object"==typeof e.schema&&(n=e.schema),this.schema=e.schema,this.schemaId=e.schemaId,this.root=e.root||this,this.baseId=null!==(t=e.baseId)&&void 0!==t?t:(0,s.normalizeId)(null==n?void 0:n[e.schemaId||"$id"]),this.schemaPath=e.schemaPath,this.localRefs=e.localRefs,this.meta=e.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function u(e){const t=d.call(this,e);if(t)return t;const n=(0,s.getFullPath)(this.opts.uriResolver,e.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:u}=this.opts,h=new i.CodeGen(this.scope,{es5:a,lines:c,ownProperties:u});let p;e.$async&&(p=h.scopeValue("Error",{ref:o.default,code:i._`require("ajv/dist/runtime/validation_error").default`}));const m=h.scopeName("validate");e.validateName=m;const g={gen:h,allErrors:this.opts.allErrors,data:r.default.data,parentData:r.default.parentData,parentDataProperty:r.default.parentDataProperty,dataNames:[r.default.data],dataPathArr:[i.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:h.scopeValue("schema",!0===this.opts.code.source?{ref:e.schema,code:(0,i.stringify)(e.schema)}:{ref:e.schema}),validateName:m,ValidationError:p,schema:e.schema,schemaEnv:e,rootId:n,baseId:e.baseId||n,schemaPath:i.nil,errSchemaPath:e.schemaPath||(this.opts.jtd?"":"#"),errorPath:i._`""`,opts:this.opts,self:this};let f;try{this._compilations.add(e),(0,l.validateFunctionCode)(g),h.optimize(this.opts.code.optimize);const t=h.toString();f=`${h.scopeRefs(r.default.scope)}return ${t}`,this.opts.code.process&&(f=this.opts.code.process(f,e));const n=new Function(`${r.default.self}`,`${r.default.scope}`,f)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=e.schema,n.schemaEnv=e,e.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:t,scopeValues:h._values}),this.opts.unevaluated){const{props:e,items:t}=g;n.evaluated={props:e instanceof i.Name?void 0:e,items:t instanceof i.Name?void 0:t,dynamicProps:e instanceof i.Name,dynamicItems:t instanceof i.Name},n.source&&(n.source.evaluated=(0,i.stringify)(n.evaluated))}return e.validate=n,e}catch(t){throw delete e.validate,delete e.validateName,f&&this.logger.error("Error compiling schema, function code:",f),t}finally{this._compilations.delete(e)}}function h(e){return(0,s.inlineRef)(e.schema,this.opts.inlineRefs)?e.schema:e.validate?e:u.call(this,e)}function d(e){for(const i of this._compilations)if(n=e,(t=i).schema===n.schema&&t.root===n.root&&t.baseId===n.baseId)return i;var t,n}function p(e,t){let n;for(;"string"==typeof(n=this.refs[t]);)t=n;return n||this.schemas[t]||m.call(this,e,t)}function m(e,t){const n=this.opts.uriResolver.parse(t),i=(0,s._getFullPath)(this.opts.uriResolver,n);let o=(0,s.getFullPath)(this.opts.uriResolver,e.baseId,void 0);if(Object.keys(e.schema).length>0&&i===o)return f.call(this,n,e);const r=(0,s.normalizeId)(i),a=this.refs[r]||this.schemas[r];if("string"==typeof a){const t=m.call(this,e,a);if("object"!=typeof(null==t?void 0:t.schema))return;return f.call(this,n,t)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||u.call(this,a),r===(0,s.normalizeId)(t)){const{schema:t}=a,{schemaId:n}=this.opts,i=t[n];return i&&(o=(0,s.resolveUrl)(this.opts.uriResolver,o,i)),new c({schema:t,schemaId:n,root:e,baseId:o})}return f.call(this,n,a)}}t.SchemaEnv=c,t.compileSchema=u,t.resolveRef=function(e,t,n){var i;n=(0,s.resolveUrl)(this.opts.uriResolver,t,n);const o=e.refs[n];if(o)return o;let r=p.call(this,e,n);if(void 0===r){const o=null===(i=e.localRefs)||void 0===i?void 0:i[n],{schemaId:s}=this.opts;o&&(r=new c({schema:o,schemaId:s,root:e,baseId:t}))}return void 0!==r?e.refs[n]=h.call(this,r):void 0},t.getCompilingSchema=d,t.resolveSchema=m;const g=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function f(e,{baseId:t,schema:n,root:i}){var o;if("/"!==(null===(o=e.fragment)||void 0===o?void 0:o[0]))return;for(const i of e.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const e=n[(0,a.unescapeFragment)(i)];if(void 0===e)return;const o="object"==typeof(n=e)&&n[this.opts.schemaId];!g.has(i)&&o&&(t=(0,s.resolveUrl)(this.opts.uriResolver,t,o))}let r;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const e=(0,s.resolveUrl)(this.opts.uriResolver,t,n.$ref);r=m.call(this,i,e)}const{schemaId:l}=this.opts;return r=r||new c({schema:n,schemaId:l,root:i,baseId:t}),r.schema!==r.root.schema?r:void 0}},2023:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={data:new i.Name("data"),valCxt:new i.Name("valCxt"),instancePath:new i.Name("instancePath"),parentData:new i.Name("parentData"),parentDataProperty:new i.Name("parentDataProperty"),rootData:new i.Name("rootData"),dynamicAnchors:new i.Name("dynamicAnchors"),vErrors:new i.Name("vErrors"),errors:new i.Name("errors"),this:new i.Name("this"),self:new i.Name("self"),scope:new i.Name("scope"),json:new i.Name("json"),jsonPos:new i.Name("jsonPos"),jsonLen:new i.Name("jsonLen"),jsonPart:new i.Name("jsonPart")};t.default=o},4551:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(6939);class o extends Error{constructor(e,t,n,o){super(o||`can't resolve reference ${n} from id ${t}`),this.missingRef=(0,i.resolveUrl)(e,t,n),this.missingSchema=(0,i.normalizeId)((0,i.getFullPath)(e,this.missingRef))}}t.default=o},6939:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getSchemaRefs=t.resolveUrl=t.normalizeId=t._getFullPath=t.getFullPath=t.inlineRef=void 0;const i=n(4227),o=n(2017),r=n(7106),s=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);t.inlineRef=function(e,t=!0){return"boolean"==typeof e||(!0===t?!l(e):!!t&&c(e)<=t)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(e){for(const t in e){if(a.has(t))return!0;const n=e[t];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(e){let t=0;for(const n in e){if("$ref"===n)return 1/0;if(t++,!s.has(n)&&("object"==typeof e[n]&&(0,i.eachItem)(e[n],(e=>t+=c(e))),t===1/0))return 1/0}return t}function u(e,t="",n){!1!==n&&(t=p(t));const i=e.parse(t);return h(e,i)}function h(e,t){return e.serialize(t).split("#")[0]+"#"}t.getFullPath=u,t._getFullPath=h;const d=/#\/?$/;function p(e){return e?e.replace(d,""):""}t.normalizeId=p,t.resolveUrl=function(e,t,n){return n=p(n),e.resolve(t,n)};const m=/^[a-z_][-a-z0-9._]*$/i;t.getSchemaRefs=function(e,t){if("boolean"==typeof e)return{};const{schemaId:n,uriResolver:i}=this.opts,s=p(e[n]||t),a={"":s},l=u(i,s,!1),c={},h=new Set;return r(e,{allKeys:!0},((e,t,i,o)=>{if(void 0===o)return;const r=l+t;let s=a[o];function u(t){const n=this.opts.uriResolver.resolve;if(t=p(s?n(s,t):t),h.has(t))throw g(t);h.add(t);let i=this.refs[t];return"string"==typeof i&&(i=this.refs[i]),"object"==typeof i?d(e,i.schema,t):t!==p(r)&&("#"===t[0]?(d(e,c[t],t),c[t]=e):this.refs[t]=r),t}function f(e){if("string"==typeof e){if(!m.test(e))throw new Error(`invalid anchor "${e}"`);u.call(this,`#${e}`)}}"string"==typeof e[n]&&(s=u.call(this,e[n])),f.call(this,e.$anchor),f.call(this,e.$dynamicAnchor),a[t]=s})),c;function d(e,t,n){if(void 0!==t&&!o(e,t))throw g(n)}function g(e){return new Error(`reference "${e}" resolves to more than one schema`)}}},396:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getRules=t.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);t.isJSONType=function(e){return"string"==typeof e&&n.has(e)},t.getRules=function(){const e={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...e,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},e.number,e.string,e.array,e.object],post:{rules:[]},all:{},keywords:{}}}},4227:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.checkStrictMode=t.getErrorPath=t.Type=t.useFunc=t.setEvaluated=t.evaluatedPropsToName=t.mergeEvaluated=t.eachItem=t.unescapeJsonPointer=t.escapeJsonPointer=t.escapeFragment=t.unescapeFragment=t.schemaRefOrVal=t.schemaHasRulesButRef=t.schemaHasRules=t.checkUnknownRules=t.alwaysValidSchema=t.toHash=void 0;const i=n(9029),o=n(1520);function r(e,t=e.schema){const{opts:n,self:i}=e;if(!n.strictSchema)return;if("boolean"==typeof t)return;const o=i.RULES.keywords;for(const n in t)o[n]||m(e,`unknown keyword: "${n}"`)}function s(e,t){if("boolean"==typeof e)return!e;for(const n in e)if(t[n])return!0;return!1}function a(e){return"number"==typeof e?`${e}`:e.replace(/~/g,"~0").replace(/\//g,"~1")}function l(e){return e.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:e,mergeToName:t,mergeValues:n,resultToName:o}){return(r,s,a,l)=>{const c=void 0===a?s:a instanceof i.Name?(s instanceof i.Name?e(r,s,a):t(r,s,a),a):s instanceof i.Name?(t(r,a,s),s):n(s,a);return l!==i.Name||c instanceof i.Name?c:o(r,c)}}function u(e,t){if(!0===t)return e.var("props",!0);const n=e.var("props",i._`{}`);return void 0!==t&&h(e,n,t),n}function h(e,t,n){Object.keys(n).forEach((n=>e.assign(i._`${t}${(0,i.getProperty)(n)}`,!0)))}t.toHash=function(e){const t={};for(const n of e)t[n]=!0;return t},t.alwaysValidSchema=function(e,t){return"boolean"==typeof t?t:0===Object.keys(t).length||(r(e,t),!s(t,e.self.RULES.all))},t.checkUnknownRules=r,t.schemaHasRules=s,t.schemaHasRulesButRef=function(e,t){if("boolean"==typeof e)return!e;for(const n in e)if("$ref"!==n&&t.all[n])return!0;return!1},t.schemaRefOrVal=function({topSchemaRef:e,schemaPath:t},n,o,r){if(!r){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return i._`${n}`}return i._`${e}${t}${(0,i.getProperty)(o)}`},t.unescapeFragment=function(e){return l(decodeURIComponent(e))},t.escapeFragment=function(e){return encodeURIComponent(a(e))},t.escapeJsonPointer=a,t.unescapeJsonPointer=l,t.eachItem=function(e,t){if(Array.isArray(e))for(const n of e)t(n);else t(e)},t.mergeEvaluated={props:c({mergeNames:(e,t,n)=>e.if(i._`${n} !== true && ${t} !== undefined`,(()=>{e.if(i._`${t} === true`,(()=>e.assign(n,!0)),(()=>e.assign(n,i._`${n} || {}`).code(i._`Object.assign(${n}, ${t})`)))})),mergeToName:(e,t,n)=>e.if(i._`${n} !== true`,(()=>{!0===t?e.assign(n,!0):(e.assign(n,i._`${n} || {}`),h(e,n,t))})),mergeValues:(e,t)=>!0===e||{...e,...t},resultToName:u}),items:c({mergeNames:(e,t,n)=>e.if(i._`${n} !== true && ${t} !== undefined`,(()=>e.assign(n,i._`${t} === true ? true : ${n} > ${t} ? ${n} : ${t}`))),mergeToName:(e,t,n)=>e.if(i._`${n} !== true`,(()=>e.assign(n,!0===t||i._`${n} > ${t} ? ${n} : ${t}`))),mergeValues:(e,t)=>!0===e||Math.max(e,t),resultToName:(e,t)=>e.var("items",t)})},t.evaluatedPropsToName=u,t.setEvaluated=h;const d={};var p;function m(e,t,n=e.opts.strictSchema){if(n){if(t=`strict mode: ${t}`,!0===n)throw new Error(t);e.self.logger.warn(t)}}t.useFunc=function(e,t){return e.scopeValue("func",{ref:t,code:d[t.code]||(d[t.code]=new o._Code(t.code))})},function(e){e[e.Num=0]="Num",e[e.Str=1]="Str"}(p||(t.Type=p={})),t.getErrorPath=function(e,t,n){if(e instanceof i.Name){const o=t===p.Num;return n?o?i._`"[" + ${e} + "]"`:i._`"['" + ${e} + "']"`:o?i._`"/" + ${e}`:i._`"/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,i.getProperty)(e).toString():"/"+a(e)},t.checkStrictMode=m},7887:(e,t)=>{"use strict";function n(e,t){return t.rules.some((t=>i(e,t)))}function i(e,t){var n;return void 0!==e[t.keyword]||(null===(n=t.definition.implements)||void 0===n?void 0:n.some((t=>void 0!==e[t])))}Object.defineProperty(t,"__esModule",{value:!0}),t.shouldUseRule=t.shouldUseGroup=t.schemaHasRulesForType=void 0,t.schemaHasRulesForType=function({schema:e,self:t},i){const o=t.RULES.types[i];return o&&!0!==o&&n(e,o)},t.shouldUseGroup=n,t.shouldUseRule=i},8727:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.boolOrEmptySchema=t.topBoolOrEmptySchema=void 0;const i=n(8708),o=n(9029),r=n(2023),s={message:"boolean schema is false"};function a(e,t){const{gen:n,data:o}=e,r={gen:n,keyword:"false schema",data:o,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:e};(0,i.reportError)(r,s,void 0,t)}t.topBoolOrEmptySchema=function(e){const{gen:t,schema:n,validateName:i}=e;!1===n?a(e,!1):"object"==typeof n&&!0===n.$async?t.return(r.default.data):(t.assign(o._`${i}.errors`,null),t.return(!0))},t.boolOrEmptySchema=function(e,t){const{gen:n,schema:i}=e;!1===i?(n.var(t,!1),a(e)):n.var(t,!0)}},208:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const i=n(396),o=n(7887),r=n(8708),s=n(9029),a=n(4227);var l;function c(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(i.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(l||(t.DataType=l={})),t.getSchemaTypes=function(e){const t=c(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=c,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:i,opts:r}=e,a=function(e,t){return t?e.filter((e=>u.has(e)||"array"===t&&"array"===e)):[]}(t,r.coerceTypes),c=t.length>0&&!(0===a.length&&1===t.length&&(0,o.schemaHasRulesForType)(e,t[0]));if(c){const o=d(t,i,r.strictNumbers,l.Wrong);n.if(o,(()=>{a.length?function(e,t,n){const{gen:i,data:o,opts:r}=e,a=i.let("dataType",s._`typeof ${o}`),l=i.let("coerced",s._`undefined`);"array"===r.coerceTypes&&i.if(s._`${a} == 'object' && Array.isArray(${o}) && ${o}.length == 1`,(()=>i.assign(o,s._`${o}[0]`).assign(a,s._`typeof ${o}`).if(d(t,o,r.strictNumbers),(()=>i.assign(l,o))))),i.if(s._`${l} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===r.coerceTypes)&&c(e);function c(e){switch(e){case"string":return void i.elseIf(s._`${a} == "number" || ${a} == "boolean"`).assign(l,s._`"" + ${o}`).elseIf(s._`${o} === null`).assign(l,s._`""`);case"number":return void i.elseIf(s._`${a} == "boolean" || ${o} === null
               || (${a} == "string" && ${o} && ${o} == +${o})`).assign(l,s._`+${o}`);case"integer":return void i.elseIf(s._`${a} === "boolean" || ${o} === null
               || (${a} === "string" && ${o} && ${o} == +${o} && !(${o} % 1))`).assign(l,s._`+${o}`);case"boolean":return void i.elseIf(s._`${o} === "false" || ${o} === 0 || ${o} === null`).assign(l,!1).elseIf(s._`${o} === "true" || ${o} === 1`).assign(l,!0);case"null":return i.elseIf(s._`${o} === "" || ${o} === 0 || ${o} === false`),void i.assign(l,null);case"array":i.elseIf(s._`${a} === "string" || ${a} === "number"
-              || ${a} === "boolean" || ${o} === null`).assign(l,s._`[${o}]`)}}i.else(),m(t),i.endIf(),i.if(s._`${l} !== undefined`,(()=>{i.assign(o,l),function({gen:t,parentData:e,parentDataProperty:n},i){t.if(s._`${e} !== undefined`,(()=>t.assign(s._`${e}[${n}]`,i)))}(t,l)}))}(t,e,a):m(t)}))}return c};const h=new Set(["string","number","integer","boolean","null"]);function u(t,e,n,i=l.Correct){const o=i===l.Correct?s.operators.EQ:s.operators.NEQ;let r;switch(t){case"null":return s._`${e} ${o} null`;case"array":r=s._`Array.isArray(${e})`;break;case"object":r=s._`${e} && typeof ${e} == "object" && !Array.isArray(${e})`;break;case"integer":r=a(s._`!(${e} % 1) && !isNaN(${e})`);break;case"number":r=a();break;default:return s._`typeof ${e} ${o} ${t}`}return i===l.Correct?r:(0,s.not)(r);function a(t=s.nil){return(0,s.and)(s._`typeof ${e} == "number"`,t,n?s._`isFinite(${e})`:s.nil)}}function d(t,e,n,i){if(1===t.length)return u(t[0],e,n,i);let o;const r=(0,a.toHash)(t);if(r.array&&r.object){const t=s._`typeof ${e} != "object"`;o=r.null?t:s._`!${e} || ${t}`,delete r.null,delete r.array,delete r.object}else o=s.nil;r.number&&delete r.integer;for(const t in r)o=(0,s.and)(o,u(t,e,n,i));return o}e.checkDataType=u,e.checkDataTypes=d;const p={message:({schema:t})=>`must be ${t}`,params:({schema:t,schemaValue:e})=>"string"==typeof t?s._`{type: ${t}}`:s._`{type: ${e}}`};function m(t){const e=function(t){const{gen:e,data:n,schema:i}=t,o=(0,a.schemaRefOrVal)(t,i,"type");return{gen:e,keyword:"type",data:n,schema:i.type,schemaCode:o,schemaValue:o,parentSchema:i,params:{},it:t}}(t);(0,r.reportError)(e,p)}e.reportTypeError=m},7870:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.assignDefaults=void 0;const i=n(9029),o=n(4227);function r(t,e,n){const{gen:r,compositeRule:s,data:a,opts:l}=t;if(void 0===n)return;const c=i._`${a}${(0,i.getProperty)(e)}`;if(s)return void(0,o.checkStrictMode)(t,`default is ignored for: ${c}`);let h=i._`${c} === undefined`;"empty"===l.useDefaults&&(h=i._`${h} || ${c} === null || ${c} === ""`),r.if(h,i._`${c} = ${(0,i.stringify)(n)}`)}e.assignDefaults=function(t,e){const{properties:n,items:i}=t.schema;if("object"===e&&n)for(const e in n)r(t,e,n[e].default);else"array"===e&&Array.isArray(i)&&i.forEach(((e,n)=>r(t,n,e.default)))}},2586:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getData=e.KeywordCxt=e.validateFunctionCode=void 0;const i=n(8727),o=n(208),r=n(7887),s=n(208),a=n(7870),l=n(3673),c=n(4495),h=n(9029),u=n(2023),d=n(6939),p=n(4227),m=n(8708);function f({gen:t,validateName:e,schema:n,schemaEnv:i,opts:o},r){o.code.es5?t.func(e,h._`${u.default.data}, ${u.default.valCxt}`,i.$async,(()=>{t.code(h._`"use strict"; ${g(n,o)}`),function(t,e){t.if(u.default.valCxt,(()=>{t.var(u.default.instancePath,h._`${u.default.valCxt}.${u.default.instancePath}`),t.var(u.default.parentData,h._`${u.default.valCxt}.${u.default.parentData}`),t.var(u.default.parentDataProperty,h._`${u.default.valCxt}.${u.default.parentDataProperty}`),t.var(u.default.rootData,h._`${u.default.valCxt}.${u.default.rootData}`),e.dynamicRef&&t.var(u.default.dynamicAnchors,h._`${u.default.valCxt}.${u.default.dynamicAnchors}`)}),(()=>{t.var(u.default.instancePath,h._`""`),t.var(u.default.parentData,h._`undefined`),t.var(u.default.parentDataProperty,h._`undefined`),t.var(u.default.rootData,u.default.data),e.dynamicRef&&t.var(u.default.dynamicAnchors,h._`{}`)}))}(t,o),t.code(r)})):t.func(e,h._`${u.default.data}, ${function(t){return h._`{${u.default.instancePath}="", ${u.default.parentData}, ${u.default.parentDataProperty}, ${u.default.rootData}=${u.default.data}${t.dynamicRef?h._`, ${u.default.dynamicAnchors}={}`:h.nil}}={}`}(o)}`,i.$async,(()=>t.code(g(n,o)).code(r)))}function g(t,e){const n="object"==typeof t&&t[e.schemaId];return n&&(e.code.source||e.code.process)?h._`/*# sourceURL=${n} */`:h.nil}function y({schema:t,self:e}){if("boolean"==typeof t)return!t;for(const n in t)if(e.RULES.all[n])return!0;return!1}function b(t){return"boolean"!=typeof t.schema}function v(t){(0,p.checkUnknownRules)(t),function(t){const{schema:e,errSchemaPath:n,opts:i,self:o}=t;e.$ref&&i.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(e,o.RULES)&&o.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(t)}function w(t,e){if(t.opts.jtd)return A(t,[],!1,e);const n=(0,o.getSchemaTypes)(t.schema);A(t,n,!(0,o.coerceAndCheckDataType)(t,n),e)}function C({gen:t,schemaEnv:e,schema:n,errSchemaPath:i,opts:o}){const r=n.$comment;if(!0===o.$comment)t.code(h._`${u.default.self}.logger.log(${r})`);else if("function"==typeof o.$comment){const n=h.str`${i}/$comment`,o=t.scopeValue("root",{ref:e.root});t.code(h._`${u.default.self}.opts.$comment(${r}, ${n}, ${o}.schema)`)}}function A(t,e,n,i){const{gen:o,schema:a,data:l,allErrors:c,opts:d,self:m}=t,{RULES:f}=m;function g(p){(0,r.shouldUseGroup)(a,p)&&(p.type?(o.if((0,s.checkDataType)(p.type,l,d.strictNumbers)),S(t,p),1===e.length&&e[0]===p.type&&n&&(o.else(),(0,s.reportTypeError)(t)),o.endIf()):S(t,p),c||o.if(h._`${u.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,f)?(d.jtd||function(t,e){!t.schemaEnv.meta&&t.opts.strictTypes&&(function(t,e){e.length&&(t.dataTypes.length?(e.forEach((e=>{x(t.dataTypes,e)||E(t,`type "${e}" not allowed by context "${t.dataTypes.join(",")}"`)})),function(t,e){const n=[];for(const i of t.dataTypes)x(e,i)?n.push(i):e.includes("integer")&&"number"===i&&n.push("integer");t.dataTypes=n}(t,e)):t.dataTypes=e)}(t,e),t.opts.allowUnionTypes||function(t,e){e.length>1&&(2!==e.length||!e.includes("null"))&&E(t,"use allowUnionTypes to allow union type keyword")}(t,e),function(t,e){const n=t.self.RULES.all;for(const i in n){const o=n[i];if("object"==typeof o&&(0,r.shouldUseRule)(t.schema,o)){const{type:n}=o.definition;n.length&&!n.some((t=>{return i=t,(n=e).includes(i)||"number"===i&&n.includes("integer");var n,i}))&&E(t,`missing type "${n.join(",")}" for keyword "${i}"`)}}}(t,t.dataTypes))}(t,e),o.block((()=>{for(const t of f.rules)g(t);g(f.post)}))):o.block((()=>M(t,"$ref",f.all.$ref.definition)))}function S(t,e){const{gen:n,schema:i,opts:{useDefaults:o}}=t;o&&(0,a.assignDefaults)(t,e.type),n.block((()=>{for(const n of e.rules)(0,r.shouldUseRule)(i,n)&&M(t,n.keyword,n.definition,e.type)}))}function x(t,e){return t.includes(e)||"integer"===e&&t.includes("number")}function E(t,e){e+=` at "${t.schemaEnv.baseId+t.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(t,e,t.opts.strictTypes)}e.validateFunctionCode=function(t){b(t)&&(v(t),y(t))?function(t){const{schema:e,opts:n,gen:i}=t;f(t,(()=>{n.$comment&&e.$comment&&C(t),function(t){const{schema:e,opts:n}=t;void 0!==e.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(t,"default is ignored in the schema root")}(t),i.let(u.default.vErrors,null),i.let(u.default.errors,0),n.unevaluated&&function(t){const{gen:e,validateName:n}=t;t.evaluated=e.const("evaluated",h._`${n}.evaluated`),e.if(h._`${t.evaluated}.dynamicProps`,(()=>e.assign(h._`${t.evaluated}.props`,h._`undefined`))),e.if(h._`${t.evaluated}.dynamicItems`,(()=>e.assign(h._`${t.evaluated}.items`,h._`undefined`)))}(t),w(t),function(t){const{gen:e,schemaEnv:n,validateName:i,ValidationError:o,opts:r}=t;n.$async?e.if(h._`${u.default.errors} === 0`,(()=>e.return(u.default.data)),(()=>e.throw(h._`new ${o}(${u.default.vErrors})`))):(e.assign(h._`${i}.errors`,u.default.vErrors),r.unevaluated&&function({gen:t,evaluated:e,props:n,items:i}){n instanceof h.Name&&t.assign(h._`${e}.props`,n),i instanceof h.Name&&t.assign(h._`${e}.items`,i)}(t),e.return(h._`${u.default.errors} === 0`))}(t)}))}(t):f(t,(()=>(0,i.topBoolOrEmptySchema)(t)))};class T{constructor(t,e,n){if((0,l.validateKeywordUsage)(t,e,n),this.gen=t.gen,this.allErrors=t.allErrors,this.keyword=n,this.data=t.data,this.schema=t.schema[n],this.$data=e.$data&&t.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,p.schemaRefOrVal)(t,this.schema,n,this.$data),this.schemaType=e.schemaType,this.parentSchema=t.schema,this.params={},this.it=t,this.def=e,this.$data)this.schemaCode=t.gen.const("vSchema",L(this.$data,t));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,e.schemaType,e.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(e.schemaType)}`);("code"in e?e.trackErrors:!1!==e.errors)&&(this.errsCount=t.gen.const("_errs",u.default.errors))}result(t,e,n){this.failResult((0,h.not)(t),e,n)}failResult(t,e,n){this.gen.if(t),n?n():this.error(),e?(this.gen.else(),e(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(t,e){this.failResult((0,h.not)(t),void 0,e)}fail(t){if(void 0===t)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(t),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(t){if(!this.$data)return this.fail(t);const{schemaCode:e}=this;this.fail(h._`${e} !== undefined && (${(0,h.or)(this.invalid$data(),t)})`)}error(t,e,n){if(e)return this.setParams(e),this._error(t,n),void this.setParams({});this._error(t,n)}_error(t,e){(t?m.reportExtraError:m.reportError)(this,this.def.error,e)}$dataError(){(0,m.reportError)(this,this.def.$dataError||m.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,m.resetErrorsCount)(this.gen,this.errsCount)}ok(t){this.allErrors||this.gen.if(t)}setParams(t,e){e?Object.assign(this.params,t):this.params=t}block$data(t,e,n=h.nil){this.gen.block((()=>{this.check$data(t,n),e()}))}check$data(t=h.nil,e=h.nil){if(!this.$data)return;const{gen:n,schemaCode:i,schemaType:o,def:r}=this;n.if((0,h.or)(h._`${i} === undefined`,e)),t!==h.nil&&n.assign(t,!0),(o.length||r.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),t!==h.nil&&n.assign(t,!1)),n.else()}invalid$data(){const{gen:t,schemaCode:e,schemaType:n,def:i,it:o}=this;return(0,h.or)(function(){if(n.length){if(!(e instanceof h.Name))throw new Error("ajv implementation error");const t=Array.isArray(n)?n:[n];return h._`${(0,s.checkDataTypes)(t,e,o.opts.strictNumbers,s.DataType.Wrong)}`}return h.nil}(),function(){if(i.validateSchema){const n=t.scopeValue("validate$data",{ref:i.validateSchema});return h._`!${n}(${e})`}return h.nil}())}subschema(t,e){const n=(0,c.getSubschema)(this.it,t);(0,c.extendSubschemaData)(n,this.it,t),(0,c.extendSubschemaMode)(n,t);const o={...this.it,...n,items:void 0,props:void 0};return function(t,e){b(t)&&(v(t),y(t))?function(t,e){const{schema:n,gen:i,opts:o}=t;o.$comment&&n.$comment&&C(t),function(t){const e=t.schema[t.opts.schemaId];e&&(t.baseId=(0,d.resolveUrl)(t.opts.uriResolver,t.baseId,e))}(t),function(t){if(t.schema.$async&&!t.schemaEnv.$async)throw new Error("async schema in sync schema")}(t);const r=i.const("_errs",u.default.errors);w(t,r),i.var(e,h._`${r} === ${u.default.errors}`)}(t,e):(0,i.boolOrEmptySchema)(t,e)}(o,e),o}mergeEvaluated(t,e){const{it:n,gen:i}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==t.props&&(n.props=p.mergeEvaluated.props(i,t.props,n.props,e)),!0!==n.items&&void 0!==t.items&&(n.items=p.mergeEvaluated.items(i,t.items,n.items,e)))}mergeValidEvaluated(t,e){const{it:n,gen:i}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return i.if(e,(()=>this.mergeEvaluated(t,h.Name))),!0}}function M(t,e,n,i){const o=new T(t,n,e);"code"in n?n.code(o,i):o.$data&&n.validate?(0,l.funcKeywordCode)(o,n):"macro"in n?(0,l.macroKeywordCode)(o,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(o,n)}e.KeywordCxt=T;const _=/^\/(?:[^~]|~0|~1)*$/,I=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function L(t,{dataLevel:e,dataNames:n,dataPathArr:i}){let o,r;if(""===t)return u.default.rootData;if("/"===t[0]){if(!_.test(t))throw new Error(`Invalid JSON-pointer: ${t}`);o=t,r=u.default.rootData}else{const s=I.exec(t);if(!s)throw new Error(`Invalid JSON-pointer: ${t}`);const a=+s[1];if(o=s[2],"#"===o){if(a>=e)throw new Error(l("property/index",a));return i[e-a]}if(a>e)throw new Error(l("data",a));if(r=n[e-a],!o)return r}let s=r;const a=o.split("/");for(const t of a)t&&(r=h._`${r}${(0,h.getProperty)((0,p.unescapeJsonPointer)(t))}`,s=h._`${s} && ${r}`);return s;function l(t,n){return`Cannot access ${t} ${n} levels up, current level is ${e}`}}e.getData=L},3673:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateKeywordUsage=e.validSchemaType=e.funcKeywordCode=e.macroKeywordCode=void 0;const i=n(9029),o=n(2023),r=n(5765),s=n(8708);function a(t){const{gen:e,data:n,it:o}=t;e.if(o.parentData,(()=>e.assign(n,i._`${o.parentData}[${o.parentDataProperty}]`)))}function l(t,e,n){if(void 0===n)throw new Error(`keyword "${e}" failed to compile`);return t.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,i.stringify)(n)})}e.macroKeywordCode=function(t,e){const{gen:n,keyword:o,schema:r,parentSchema:s,it:a}=t,c=e.macro.call(a.self,r,s,a),h=l(n,o,c);!1!==a.opts.validateSchema&&a.self.validateSchema(c,!0);const u=n.name("valid");t.subschema({schema:c,schemaPath:i.nil,errSchemaPath:`${a.errSchemaPath}/${o}`,topSchemaRef:h,compositeRule:!0},u),t.pass(u,(()=>t.error(!0)))},e.funcKeywordCode=function(t,e){var n;const{gen:c,keyword:h,schema:u,parentSchema:d,$data:p,it:m}=t;!function({schemaEnv:t},e){if(e.async&&!t.$async)throw new Error("async keyword in sync schema")}(m,e);const f=!p&&e.compile?e.compile.call(m.self,u,d,m):e.validate,g=l(c,h,f),y=c.let("valid");function b(n=(e.async?i._`await `:i.nil)){const s=m.opts.passContext?o.default.this:o.default.self,a=!("compile"in e&&!p||!1===e.schema);c.assign(y,i._`${n}${(0,r.callValidateCode)(t,g,s,a)}`,e.modifying)}function v(t){var n;c.if((0,i.not)(null!==(n=e.valid)&&void 0!==n?n:y),t)}t.block$data(y,(function(){if(!1===e.errors)b(),e.modifying&&a(t),v((()=>t.error()));else{const n=e.async?function(){const t=c.let("ruleErrs",null);return c.try((()=>b(i._`await `)),(e=>c.assign(y,!1).if(i._`${e} instanceof ${m.ValidationError}`,(()=>c.assign(t,i._`${e}.errors`)),(()=>c.throw(e))))),t}():function(){const t=i._`${g}.errors`;return c.assign(t,null),b(i.nil),t}();e.modifying&&a(t),v((()=>function(t,e){const{gen:n}=t;n.if(i._`Array.isArray(${e})`,(()=>{n.assign(o.default.vErrors,i._`${o.default.vErrors} === null ? ${e} : ${o.default.vErrors}.concat(${e})`).assign(o.default.errors,i._`${o.default.vErrors}.length`),(0,s.extendErrors)(t)}),(()=>t.error()))}(t,n)))}})),t.ok(null!==(n=e.valid)&&void 0!==n?n:y)},e.validSchemaType=function(t,e,n=!1){return!e.length||e.some((e=>"array"===e?Array.isArray(t):"object"===e?t&&"object"==typeof t&&!Array.isArray(t):typeof t==e||n&&void 0===t))},e.validateKeywordUsage=function({schema:t,opts:e,self:n,errSchemaPath:i},o,r){if(Array.isArray(o.keyword)?!o.keyword.includes(r):o.keyword!==r)throw new Error("ajv implementation error");const s=o.dependencies;if(null==s?void 0:s.some((e=>!Object.prototype.hasOwnProperty.call(t,e))))throw new Error(`parent schema must have dependencies of ${r}: ${s.join(",")}`);if(o.validateSchema&&!o.validateSchema(t[r])){const t=`keyword "${r}" value is invalid at path "${i}": `+n.errorsText(o.validateSchema.errors);if("log"!==e.validateSchema)throw new Error(t);n.logger.error(t)}}},4495:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.extendSubschemaMode=e.extendSubschemaData=e.getSubschema=void 0;const i=n(9029),o=n(4227);e.getSubschema=function(t,{keyword:e,schemaProp:n,schema:r,schemaPath:s,errSchemaPath:a,topSchemaRef:l}){if(void 0!==e&&void 0!==r)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==e){const r=t.schema[e];return void 0===n?{schema:r,schemaPath:i._`${t.schemaPath}${(0,i.getProperty)(e)}`,errSchemaPath:`${t.errSchemaPath}/${e}`}:{schema:r[n],schemaPath:i._`${t.schemaPath}${(0,i.getProperty)(e)}${(0,i.getProperty)(n)}`,errSchemaPath:`${t.errSchemaPath}/${e}/${(0,o.escapeFragment)(n)}`}}if(void 0!==r){if(void 0===s||void 0===a||void 0===l)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:r,schemaPath:s,topSchemaRef:l,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},e.extendSubschemaData=function(t,e,{dataProp:n,dataPropType:r,data:s,dataTypes:a,propertyName:l}){if(void 0!==s&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:c}=e;if(void 0!==n){const{errorPath:s,dataPathArr:a,opts:l}=e;h(c.let("data",i._`${e.data}${(0,i.getProperty)(n)}`,!0)),t.errorPath=i.str`${s}${(0,o.getErrorPath)(n,r,l.jsPropertySyntax)}`,t.parentDataProperty=i._`${n}`,t.dataPathArr=[...a,t.parentDataProperty]}function h(n){t.data=n,t.dataLevel=e.dataLevel+1,t.dataTypes=[],e.definedProperties=new Set,t.parentData=e.data,t.dataNames=[...e.dataNames,n]}void 0!==s&&(h(s instanceof i.Name?s:c.let("data",s,!0)),void 0!==l&&(t.propertyName=l)),a&&(t.dataTypes=a)},e.extendSubschemaMode=function(t,{jtdDiscriminator:e,jtdMetadata:n,compositeRule:i,createErrors:o,allErrors:r}){void 0!==i&&(t.compositeRule=i),void 0!==o&&(t.createErrors=o),void 0!==r&&(t.allErrors=r),t.jtdDiscriminator=e,t.jtdMetadata=n}},4042:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=void 0;var i=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return i.KeywordCxt}});var o=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return o._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return o.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return o.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return o.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return o.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return o.CodeGen}});const r=n(3558),s=n(4551),a=n(396),l=n(3835),c=n(9029),h=n(6939),u=n(208),d=n(4227),p=n(3837),m=n(5944),f=(t,e)=>new RegExp(t,e);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},v={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'};function w(t){var e,n,i,o,r,s,a,l,c,h,u,d,p,g,y,b,v,w,C,A,S,x,E,T,M;const _=t.strict,I=null===(e=t.code)||void 0===e?void 0:e.optimize,L=!0===I||void 0===I?1:I||0,N=null!==(i=null===(n=t.code)||void 0===n?void 0:n.regExp)&&void 0!==i?i:f,P=null!==(o=t.uriResolver)&&void 0!==o?o:m.default;return{strictSchema:null===(s=null!==(r=t.strictSchema)&&void 0!==r?r:_)||void 0===s||s,strictNumbers:null===(l=null!==(a=t.strictNumbers)&&void 0!==a?a:_)||void 0===l||l,strictTypes:null!==(h=null!==(c=t.strictTypes)&&void 0!==c?c:_)&&void 0!==h?h:"log",strictTuples:null!==(d=null!==(u=t.strictTuples)&&void 0!==u?u:_)&&void 0!==d?d:"log",strictRequired:null!==(g=null!==(p=t.strictRequired)&&void 0!==p?p:_)&&void 0!==g&&g,code:t.code?{...t.code,optimize:L,regExp:N}:{optimize:L,regExp:N},loopRequired:null!==(y=t.loopRequired)&&void 0!==y?y:200,loopEnum:null!==(b=t.loopEnum)&&void 0!==b?b:200,meta:null===(v=t.meta)||void 0===v||v,messages:null===(w=t.messages)||void 0===w||w,inlineRefs:null===(C=t.inlineRefs)||void 0===C||C,schemaId:null!==(A=t.schemaId)&&void 0!==A?A:"$id",addUsedSchema:null===(S=t.addUsedSchema)||void 0===S||S,validateSchema:null===(x=t.validateSchema)||void 0===x||x,validateFormats:null===(E=t.validateFormats)||void 0===E||E,unicodeRegExp:null===(T=t.unicodeRegExp)||void 0===T||T,int32range:null===(M=t.int32range)||void 0===M||M,uriResolver:P}}class C{constructor(t={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,t=this.opts={...t,...w(t)};const{es5:e,lines:n}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:e,lines:n}),this.logger=function(t){if(!1===t)return _;if(void 0===t)return console;if(t.log&&t.warn&&t.error)return t;throw new Error("logger must implement log, warn and error methods")}(t.logger);const i=t.validateFormats;t.validateFormats=!1,this.RULES=(0,a.getRules)(),A.call(this,b,t,"NOT SUPPORTED"),A.call(this,v,t,"DEPRECATED","warn"),this._metaOpts=M.call(this),t.formats&&E.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),t.keywords&&T.call(this,t.keywords),"object"==typeof t.meta&&this.addMetaSchema(t.meta),x.call(this),t.validateFormats=i}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:t,meta:e,schemaId:n}=this.opts;let i=p;"id"===n&&(i={...p},i.id=i.$id,delete i.$id),e&&t&&this.addMetaSchema(i,i[n],!1)}defaultMeta(){const{meta:t,schemaId:e}=this.opts;return this.opts.defaultMeta="object"==typeof t?t[e]||t:void 0}validate(t,e){let n;if("string"==typeof t){if(n=this.getSchema(t),!n)throw new Error(`no schema with key or ref "${t}"`)}else n=this.compile(t);const i=n(e);return"$async"in n||(this.errors=n.errors),i}compile(t,e){const n=this._addSchema(t,e);return n.validate||this._compileSchemaEnv(n)}compileAsync(t,e){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return i.call(this,t,e);async function i(t,e){await o.call(this,t.$schema);const n=this._addSchema(t,e);return n.validate||r.call(this,n)}async function o(t){t&&!this.getSchema(t)&&await i.call(this,{$ref:t},!0)}async function r(t){try{return this._compileSchemaEnv(t)}catch(e){if(!(e instanceof s.default))throw e;return a.call(this,e),await l.call(this,e.missingSchema),r.call(this,t)}}function a({missingSchema:t,missingRef:e}){if(this.refs[t])throw new Error(`AnySchema ${t} is loaded but ${e} cannot be resolved`)}async function l(t){const n=await c.call(this,t);this.refs[t]||await o.call(this,n.$schema),this.refs[t]||this.addSchema(n,t,e)}async function c(t){const e=this._loading[t];if(e)return e;try{return await(this._loading[t]=n(t))}finally{delete this._loading[t]}}}addSchema(t,e,n,i=this.opts.validateSchema){if(Array.isArray(t)){for(const e of t)this.addSchema(e,void 0,n,i);return this}let o;if("object"==typeof t){const{schemaId:e}=this.opts;if(o=t[e],void 0!==o&&"string"!=typeof o)throw new Error(`schema ${e} must be string`)}return e=(0,h.normalizeId)(e||o),this._checkUnique(e),this.schemas[e]=this._addSchema(t,n,e,i,!0),this}addMetaSchema(t,e,n=this.opts.validateSchema){return this.addSchema(t,e,!0,n),this}validateSchema(t,e){if("boolean"==typeof t)return!0;let n;if(n=t.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const i=this.validate(n,t);if(!i&&e){const t="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(t);this.logger.error(t)}return i}getSchema(t){let e;for(;"string"==typeof(e=S.call(this,t));)t=e;if(void 0===e){const{schemaId:n}=this.opts,i=new l.SchemaEnv({schema:{},schemaId:n});if(e=l.resolveSchema.call(this,i,t),!e)return;this.refs[t]=e}return e.validate||this._compileSchemaEnv(e)}removeSchema(t){if(t instanceof RegExp)return this._removeAllSchemas(this.schemas,t),this._removeAllSchemas(this.refs,t),this;switch(typeof t){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const e=S.call(this,t);return"object"==typeof e&&this._cache.delete(e.schema),delete this.schemas[t],delete this.refs[t],this}case"object":{const e=t;this._cache.delete(e);let n=t[this.opts.schemaId];return n&&(n=(0,h.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(t){for(const e of t)this.addKeyword(e);return this}addKeyword(t,e){let n;if("string"==typeof t)n=t,"object"==typeof e&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),e.keyword=n);else{if("object"!=typeof t||void 0!==e)throw new Error("invalid addKeywords parameters");if(n=(e=t).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if(L.call(this,n,e),!e)return(0,d.eachItem)(n,(t=>N.call(this,t))),this;$.call(this,e);const i={...e,type:(0,u.getJSONTypes)(e.type),schemaType:(0,u.getJSONTypes)(e.schemaType)};return(0,d.eachItem)(n,0===i.type.length?t=>N.call(this,t,i):t=>i.type.forEach((e=>N.call(this,t,i,e)))),this}getKeyword(t){const e=this.RULES.all[t];return"object"==typeof e?e.definition:!!e}removeKeyword(t){const{RULES:e}=this;delete e.keywords[t],delete e.all[t];for(const n of e.rules){const e=n.rules.findIndex((e=>e.keyword===t));e>=0&&n.rules.splice(e,1)}return this}addFormat(t,e){return"string"==typeof e&&(e=new RegExp(e)),this.formats[t]=e,this}errorsText(t=this.errors,{separator:e=", ",dataVar:n="data"}={}){return t&&0!==t.length?t.map((t=>`${n}${t.instancePath} ${t.message}`)).reduce(((t,n)=>t+e+n)):"No errors"}$dataMetaSchema(t,e){const n=this.RULES.all;t=JSON.parse(JSON.stringify(t));for(const i of e){const e=i.split("/").slice(1);let o=t;for(const t of e)o=o[t];for(const t in n){const e=n[t];if("object"!=typeof e)continue;const{$data:i}=e.definition,r=o[t];i&&r&&(o[t]=k(r))}}return t}_removeAllSchemas(t,e){for(const n in t){const i=t[n];e&&!e.test(n)||("string"==typeof i?delete t[n]:i&&!i.meta&&(this._cache.delete(i.schema),delete t[n]))}}_addSchema(t,e,n,i=this.opts.validateSchema,o=this.opts.addUsedSchema){let r;const{schemaId:s}=this.opts;if("object"==typeof t)r=t[s];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof t)throw new Error("schema must be object or boolean")}let a=this._cache.get(t);if(void 0!==a)return a;n=(0,h.normalizeId)(r||n);const c=h.getSchemaRefs.call(this,t,n);return a=new l.SchemaEnv({schema:t,schemaId:s,meta:e,baseId:n,localRefs:c}),this._cache.set(a.schema,a),o&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),i&&this.validateSchema(t,!0),a}_checkUnique(t){if(this.schemas[t]||this.refs[t])throw new Error(`schema with key or id "${t}" already exists`)}_compileSchemaEnv(t){if(t.meta?this._compileMetaSchema(t):l.compileSchema.call(this,t),!t.validate)throw new Error("ajv implementation error");return t.validate}_compileMetaSchema(t){const e=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,t)}finally{this.opts=e}}}function A(t,e,n,i="error"){for(const o in t){const r=o;r in e&&this.logger[i](`${n}: option ${o}. ${t[r]}`)}}function S(t){return t=(0,h.normalizeId)(t),this.schemas[t]||this.refs[t]}function x(){const t=this.opts.schemas;if(t)if(Array.isArray(t))this.addSchema(t);else for(const e in t)this.addSchema(t[e],e)}function E(){for(const t in this.opts.formats){const e=this.opts.formats[t];e&&this.addFormat(t,e)}}function T(t){if(Array.isArray(t))this.addVocabulary(t);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const e in t){const n=t[e];n.keyword||(n.keyword=e),this.addKeyword(n)}}}function M(){const t={...this.opts};for(const e of g)delete t[e];return t}C.ValidationError=r.default,C.MissingRefError=s.default,e.default=C;const _={log(){},warn(){},error(){}},I=/^[a-z_$][a-z0-9_$:-]*$/i;function L(t,e){const{RULES:n}=this;if((0,d.eachItem)(t,(t=>{if(n.keywords[t])throw new Error(`Keyword ${t} is already defined`);if(!I.test(t))throw new Error(`Keyword ${t} has invalid name`)})),e&&e.$data&&!("code"in e)&&!("validate"in e))throw new Error('$data keyword must have "code" or "validate" function')}function N(t,e,n){var i;const o=null==e?void 0:e.post;if(n&&o)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:r}=this;let s=o?r.post:r.rules.find((({type:t})=>t===n));if(s||(s={type:n,rules:[]},r.rules.push(s)),r.keywords[t]=!0,!e)return;const a={keyword:t,definition:{...e,type:(0,u.getJSONTypes)(e.type),schemaType:(0,u.getJSONTypes)(e.schemaType)}};e.before?P.call(this,s,a,e.before):s.rules.push(a),r.all[t]=a,null===(i=e.implements)||void 0===i||i.forEach((t=>this.addKeyword(t)))}function P(t,e,n){const i=t.rules.findIndex((t=>t.keyword===n));i>=0?t.rules.splice(i,0,e):(t.rules.push(e),this.logger.warn(`rule ${n} is not defined`))}function $(t){let{metaSchema:e}=t;void 0!==e&&(t.$data&&this.opts.$data&&(e=k(e)),t.validateSchema=this.compile(e,!0))}const R={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function k(t){return{anyOf:[t,R]}}},9572:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(1678),o=n(7216),r=n(9547),s=n(8226),a=n(518),l=n(4588),c=n(5707),h=n(7082),u=["/properties"];e.default=function(t){return[i,o,r,s,a,e(this,l),c,e(this,h)].forEach((t=>this.addMetaSchema(t,void 0,!1))),this;function e(e,n){return t?e.$dataMetaSchema(n,u):n}}},6250:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2017);i.code='require("ajv/dist/runtime/equal").default',e.default=i},3853:(t,e)=>{"use strict";function n(t){const e=t.length;let n,i=0,o=0;for(;o<e;)i++,n=t.charCodeAt(o++),n>=55296&&n<=56319&&o<e&&(n=t.charCodeAt(o),56320==(64512&n)&&o++);return i}Object.defineProperty(e,"__esModule",{value:!0}),e.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},5944:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(8343);i.code='require("ajv/dist/runtime/uri").default',e.default=i},3558:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});class n extends Error{constructor(t){super("validation failed"),this.errors=t,this.ajv=this.validation=!0}}e.default=n},5457:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateAdditionalItems=void 0;const i=n(9029),o=n(4227),r={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{parentSchema:e,it:n}=t,{items:i}=e;Array.isArray(i)?s(t,i):(0,o.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function s(t,e){const{gen:n,schema:r,data:s,keyword:a,it:l}=t;l.items=!0;const c=n.const("len",i._`${s}.length`);if(!1===r)t.setParams({len:e.length}),t.pass(i._`${c} <= ${e.length}`);else if("object"==typeof r&&!(0,o.alwaysValidSchema)(l,r)){const r=n.var("valid",i._`${c} <= ${e.length}`);n.if((0,i.not)(r),(()=>function(r){n.forRange("i",e.length,c,(e=>{t.subschema({keyword:a,dataProp:e,dataPropType:o.Type.Num},r),l.allErrors||n.if((0,i.not)(r),(()=>n.break()))}))}(r))),t.ok(r)}}e.validateAdditionalItems=s,e.default=r},8660:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(2023),s=n(4227),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:t})=>o._`{additionalProperty: ${t.additionalProperty}}`},code(t){const{gen:e,schema:n,parentSchema:a,data:l,errsCount:c,it:h}=t;if(!c)throw new Error("ajv implementation error");const{allErrors:u,opts:d}=h;if(h.props=!0,"all"!==d.removeAdditional&&(0,s.alwaysValidSchema)(h,n))return;const p=(0,i.allSchemaProperties)(a.properties),m=(0,i.allSchemaProperties)(a.patternProperties);function f(t){e.code(o._`delete ${l}[${t}]`)}function g(i){if("all"===d.removeAdditional||d.removeAdditional&&!1===n)f(i);else{if(!1===n)return t.setParams({additionalProperty:i}),t.error(),void(u||e.break());if("object"==typeof n&&!(0,s.alwaysValidSchema)(h,n)){const n=e.name("valid");"failing"===d.removeAdditional?(y(i,n,!1),e.if((0,o.not)(n),(()=>{t.reset(),f(i)}))):(y(i,n),u||e.if((0,o.not)(n),(()=>e.break())))}}}function y(e,n,i){const o={keyword:"additionalProperties",dataProp:e,dataPropType:s.Type.Str};!1===i&&Object.assign(o,{compositeRule:!0,createErrors:!1,allErrors:!1}),t.subschema(o,n)}e.forIn("key",l,(n=>{p.length||m.length?e.if(function(n){let r;if(p.length>8){const t=(0,s.schemaRefOrVal)(h,a.properties,"properties");r=(0,i.isOwnProperty)(e,t,n)}else r=p.length?(0,o.or)(...p.map((t=>o._`${n} === ${t}`))):o.nil;return m.length&&(r=(0,o.or)(r,...m.map((e=>o._`${(0,i.usePattern)(t,e)}.test(${n})`)))),(0,o.not)(r)}(n),(()=>g(n))):g(n)})),t.ok(o._`${c} === ${r.default.errors}`)}};e.default=a},5844:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),o={keyword:"allOf",schemaType:"array",code(t){const{gen:e,schema:n,it:o}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");const r=e.name("valid");n.forEach(((e,n)=>{if((0,i.alwaysValidSchema)(o,e))return;const s=t.subschema({keyword:"allOf",schemaProp:n},r);t.ok(r),t.mergeEvaluated(s)}))}};e.default=o},6505:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};e.default=i},2661:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:t,max:e}})=>void 0===e?i.str`must contain at least ${t} valid item(s)`:i.str`must contain at least ${t} and no more than ${e} valid item(s)`,params:({params:{min:t,max:e}})=>void 0===e?i._`{minContains: ${t}}`:i._`{minContains: ${t}, maxContains: ${e}}`},code(t){const{gen:e,schema:n,parentSchema:r,data:s,it:a}=t;let l,c;const{minContains:h,maxContains:u}=r;a.opts.next?(l=void 0===h?1:h,c=u):l=1;const d=e.const("len",i._`${s}.length`);if(t.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,o.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,o.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void t.fail();if((0,o.alwaysValidSchema)(a,n)){let e=i._`${d} >= ${l}`;return void 0!==c&&(e=i._`${e} && ${d} <= ${c}`),void t.pass(e)}a.items=!0;const p=e.name("valid");function m(){const t=e.name("_valid"),n=e.let("count",0);f(t,(()=>e.if(t,(()=>function(t){e.code(i._`${t}++`),void 0===c?e.if(i._`${t} >= ${l}`,(()=>e.assign(p,!0).break())):(e.if(i._`${t} > ${c}`,(()=>e.assign(p,!1).break())),1===l?e.assign(p,!0):e.if(i._`${t} >= ${l}`,(()=>e.assign(p,!0))))}(n)))))}function f(n,i){e.forRange("i",0,d,(e=>{t.subschema({keyword:"contains",dataProp:e,dataPropType:o.Type.Num,compositeRule:!0},n),i()}))}void 0===c&&1===l?f(p,(()=>e.if(p,(()=>e.break())))):0===l?(e.let(p,!0),void 0!==c&&e.if(i._`${s}.length > 0`,m)):(e.let(p,!1),m()),t.result(p,(()=>t.reset()))}};e.default=r},3025:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateSchemaDeps=e.validatePropertyDeps=e.error=void 0;const i=n(9029),o=n(4227),r=n(5765);e.error={message:({params:{property:t,depsCount:e,deps:n}})=>{const o=1===e?"property":"properties";return i.str`must have ${o} ${n} when property ${t} is present`},params:({params:{property:t,depsCount:e,deps:n,missingProperty:o}})=>i._`{property: ${t},
+              || ${a} === "boolean" || ${o} === null`).assign(l,s._`[${o}]`)}}i.else(),m(e),i.endIf(),i.if(s._`${l} !== undefined`,(()=>{i.assign(o,l),function({gen:e,parentData:t,parentDataProperty:n},i){e.if(s._`${t} !== undefined`,(()=>e.assign(s._`${t}[${n}]`,i)))}(e,l)}))}(e,t,a):m(e)}))}return c};const u=new Set(["string","number","integer","boolean","null"]);function h(e,t,n,i=l.Correct){const o=i===l.Correct?s.operators.EQ:s.operators.NEQ;let r;switch(e){case"null":return s._`${t} ${o} null`;case"array":r=s._`Array.isArray(${t})`;break;case"object":r=s._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":r=a(s._`!(${t} % 1) && !isNaN(${t})`);break;case"number":r=a();break;default:return s._`typeof ${t} ${o} ${e}`}return i===l.Correct?r:(0,s.not)(r);function a(e=s.nil){return(0,s.and)(s._`typeof ${t} == "number"`,e,n?s._`isFinite(${t})`:s.nil)}}function d(e,t,n,i){if(1===e.length)return h(e[0],t,n,i);let o;const r=(0,a.toHash)(e);if(r.array&&r.object){const e=s._`typeof ${t} != "object"`;o=r.null?e:s._`!${t} || ${e}`,delete r.null,delete r.array,delete r.object}else o=s.nil;r.number&&delete r.integer;for(const e in r)o=(0,s.and)(o,h(e,t,n,i));return o}t.checkDataType=h,t.checkDataTypes=d;const p={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?s._`{type: ${e}}`:s._`{type: ${t}}`};function m(e){const t=function(e){const{gen:t,data:n,schema:i}=e,o=(0,a.schemaRefOrVal)(e,i,"type");return{gen:t,keyword:"type",data:n,schema:i.type,schemaCode:o,schemaValue:o,parentSchema:i,params:{},it:e}}(e);(0,r.reportError)(t,p)}t.reportTypeError=m},7870:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const i=n(9029),o=n(4227);function r(e,t,n){const{gen:r,compositeRule:s,data:a,opts:l}=e;if(void 0===n)return;const c=i._`${a}${(0,i.getProperty)(t)}`;if(s)return void(0,o.checkStrictMode)(e,`default is ignored for: ${c}`);let u=i._`${c} === undefined`;"empty"===l.useDefaults&&(u=i._`${u} || ${c} === null || ${c} === ""`),r.if(u,i._`${c} = ${(0,i.stringify)(n)}`)}t.assignDefaults=function(e,t){const{properties:n,items:i}=e.schema;if("object"===t&&n)for(const t in n)r(e,t,n[t].default);else"array"===t&&Array.isArray(i)&&i.forEach(((t,n)=>r(e,n,t.default)))}},2586:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const i=n(8727),o=n(208),r=n(7887),s=n(208),a=n(7870),l=n(3673),c=n(4495),u=n(9029),h=n(2023),d=n(6939),p=n(4227),m=n(8708);function g({gen:e,validateName:t,schema:n,schemaEnv:i,opts:o},r){o.code.es5?e.func(t,u._`${h.default.data}, ${h.default.valCxt}`,i.$async,(()=>{e.code(u._`"use strict"; ${f(n,o)}`),function(e,t){e.if(h.default.valCxt,(()=>{e.var(h.default.instancePath,u._`${h.default.valCxt}.${h.default.instancePath}`),e.var(h.default.parentData,u._`${h.default.valCxt}.${h.default.parentData}`),e.var(h.default.parentDataProperty,u._`${h.default.valCxt}.${h.default.parentDataProperty}`),e.var(h.default.rootData,u._`${h.default.valCxt}.${h.default.rootData}`),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`${h.default.valCxt}.${h.default.dynamicAnchors}`)}),(()=>{e.var(h.default.instancePath,u._`""`),e.var(h.default.parentData,u._`undefined`),e.var(h.default.parentDataProperty,u._`undefined`),e.var(h.default.rootData,h.default.data),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`{}`)}))}(e,o),e.code(r)})):e.func(t,u._`${h.default.data}, ${function(e){return u._`{${h.default.instancePath}="", ${h.default.parentData}, ${h.default.parentDataProperty}, ${h.default.rootData}=${h.default.data}${e.dynamicRef?u._`, ${h.default.dynamicAnchors}={}`:u.nil}}={}`}(o)}`,i.$async,(()=>e.code(f(n,o)).code(r)))}function f(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function b(e){return"boolean"!=typeof e.schema}function v(e){(0,p.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:i,self:o}=e;t.$ref&&i.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(t,o.RULES)&&o.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function w(e,t){if(e.opts.jtd)return S(e,[],!1,t);const n=(0,o.getSchemaTypes)(e.schema);S(e,n,!(0,o.coerceAndCheckDataType)(e,n),t)}function C({gen:e,schemaEnv:t,schema:n,errSchemaPath:i,opts:o}){const r=n.$comment;if(!0===o.$comment)e.code(u._`${h.default.self}.logger.log(${r})`);else if("function"==typeof o.$comment){const n=u.str`${i}/$comment`,o=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${r}, ${n}, ${o}.schema)`)}}function S(e,t,n,i){const{gen:o,schema:a,data:l,allErrors:c,opts:d,self:m}=e,{RULES:g}=m;function f(p){(0,r.shouldUseGroup)(a,p)&&(p.type?(o.if((0,s.checkDataType)(p.type,l,d.strictNumbers)),A(e,p),1===t.length&&t[0]===p.type&&n&&(o.else(),(0,s.reportTypeError)(e)),o.endIf()):A(e,p),c||o.if(u._`${h.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,g)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach((t=>{x(e.dataTypes,t)||M(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)})),function(e,t){const n=[];for(const i of e.dataTypes)x(t,i)?n.push(i):t.includes("integer")&&"number"===i&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&M(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const i in n){const o=n[i];if("object"==typeof o&&(0,r.shouldUseRule)(e.schema,o)){const{type:n}=o.definition;n.length&&!n.some((e=>{return i=e,(n=t).includes(i)||"number"===i&&n.includes("integer");var n,i}))&&M(e,`missing type "${n.join(",")}" for keyword "${i}"`)}}}(e,e.dataTypes))}(e,t),o.block((()=>{for(const e of g.rules)f(e);f(g.post)}))):o.block((()=>T(e,"$ref",g.all.$ref.definition)))}function A(e,t){const{gen:n,schema:i,opts:{useDefaults:o}}=e;o&&(0,a.assignDefaults)(e,t.type),n.block((()=>{for(const n of t.rules)(0,r.shouldUseRule)(i,n)&&T(e,n.keyword,n.definition,t.type)}))}function x(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function M(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(v(e),y(e))?function(e){const{schema:t,opts:n,gen:i}=e;g(e,(()=>{n.$comment&&t.$comment&&C(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(e,"default is ignored in the schema root")}(e),i.let(h.default.vErrors,null),i.let(h.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),w(e),function(e){const{gen:t,schemaEnv:n,validateName:i,ValidationError:o,opts:r}=e;n.$async?t.if(u._`${h.default.errors} === 0`,(()=>t.return(h.default.data)),(()=>t.throw(u._`new ${o}(${h.default.vErrors})`))):(t.assign(u._`${i}.errors`,h.default.vErrors),r.unevaluated&&function({gen:e,evaluated:t,props:n,items:i}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),i instanceof u.Name&&e.assign(u._`${t}.items`,i)}(e),t.return(u._`${h.default.errors} === 0`))}(e)}))}(e):g(e,(()=>(0,i.topBoolOrEmptySchema)(e)))};class E{constructor(e,t,n){if((0,l.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,p.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",L(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in t?t.trackErrors:!1!==t.errors)&&(this.errsCount=e.gen.const("_errs",h.default.errors))}result(e,t,n){this.failResult((0,u.not)(e),t,n)}failResult(e,t,n){this.gen.if(e),n?n():this.error(),t?(this.gen.else(),t(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(e,t){this.failResult((0,u.not)(e),void 0,t)}fail(e){if(void 0===e)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(e),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(e){if(!this.$data)return this.fail(e);const{schemaCode:t}=this;this.fail(u._`${t} !== undefined && (${(0,u.or)(this.invalid$data(),e)})`)}error(e,t,n){if(t)return this.setParams(t),this._error(e,n),void this.setParams({});this._error(e,n)}_error(e,t){(e?m.reportExtraError:m.reportError)(this,this.def.error,t)}$dataError(){(0,m.reportError)(this,this.def.$dataError||m.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,m.resetErrorsCount)(this.gen,this.errsCount)}ok(e){this.allErrors||this.gen.if(e)}setParams(e,t){t?Object.assign(this.params,e):this.params=e}block$data(e,t,n=u.nil){this.gen.block((()=>{this.check$data(e,n),t()}))}check$data(e=u.nil,t=u.nil){if(!this.$data)return;const{gen:n,schemaCode:i,schemaType:o,def:r}=this;n.if((0,u.or)(u._`${i} === undefined`,t)),e!==u.nil&&n.assign(e,!0),(o.length||r.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),e!==u.nil&&n.assign(e,!1)),n.else()}invalid$data(){const{gen:e,schemaCode:t,schemaType:n,def:i,it:o}=this;return(0,u.or)(function(){if(n.length){if(!(t instanceof u.Name))throw new Error("ajv implementation error");const e=Array.isArray(n)?n:[n];return u._`${(0,s.checkDataTypes)(e,t,o.opts.strictNumbers,s.DataType.Wrong)}`}return u.nil}(),function(){if(i.validateSchema){const n=e.scopeValue("validate$data",{ref:i.validateSchema});return u._`!${n}(${t})`}return u.nil}())}subschema(e,t){const n=(0,c.getSubschema)(this.it,e);(0,c.extendSubschemaData)(n,this.it,e),(0,c.extendSubschemaMode)(n,e);const o={...this.it,...n,items:void 0,props:void 0};return function(e,t){b(e)&&(v(e),y(e))?function(e,t){const{schema:n,gen:i,opts:o}=e;o.$comment&&n.$comment&&C(e),function(e){const t=e.schema[e.opts.schemaId];t&&(e.baseId=(0,d.resolveUrl)(e.opts.uriResolver,e.baseId,t))}(e),function(e){if(e.schema.$async&&!e.schemaEnv.$async)throw new Error("async schema in sync schema")}(e);const r=i.const("_errs",h.default.errors);w(e,r),i.var(t,u._`${r} === ${h.default.errors}`)}(e,t):(0,i.boolOrEmptySchema)(e,t)}(o,t),o}mergeEvaluated(e,t){const{it:n,gen:i}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==e.props&&(n.props=p.mergeEvaluated.props(i,e.props,n.props,t)),!0!==n.items&&void 0!==e.items&&(n.items=p.mergeEvaluated.items(i,e.items,n.items,t)))}mergeValidEvaluated(e,t){const{it:n,gen:i}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return i.if(t,(()=>this.mergeEvaluated(e,u.Name))),!0}}function T(e,t,n,i){const o=new E(e,n,t);"code"in n?n.code(o,i):o.$data&&n.validate?(0,l.funcKeywordCode)(o,n):"macro"in n?(0,l.macroKeywordCode)(o,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(o,n)}t.KeywordCxt=E;const _=/^\/(?:[^~]|~0|~1)*$/,I=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function L(e,{dataLevel:t,dataNames:n,dataPathArr:i}){let o,r;if(""===e)return h.default.rootData;if("/"===e[0]){if(!_.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);o=e,r=h.default.rootData}else{const s=I.exec(e);if(!s)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+s[1];if(o=s[2],"#"===o){if(a>=t)throw new Error(l("property/index",a));return i[t-a]}if(a>t)throw new Error(l("data",a));if(r=n[t-a],!o)return r}let s=r;const a=o.split("/");for(const e of a)e&&(r=u._`${r}${(0,u.getProperty)((0,p.unescapeJsonPointer)(e))}`,s=u._`${s} && ${r}`);return s;function l(e,n){return`Cannot access ${e} ${n} levels up, current level is ${t}`}}t.getData=L},3673:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateKeywordUsage=t.validSchemaType=t.funcKeywordCode=t.macroKeywordCode=void 0;const i=n(9029),o=n(2023),r=n(5765),s=n(8708);function a(e){const{gen:t,data:n,it:o}=e;t.if(o.parentData,(()=>t.assign(n,i._`${o.parentData}[${o.parentDataProperty}]`)))}function l(e,t,n){if(void 0===n)throw new Error(`keyword "${t}" failed to compile`);return e.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,i.stringify)(n)})}t.macroKeywordCode=function(e,t){const{gen:n,keyword:o,schema:r,parentSchema:s,it:a}=e,c=t.macro.call(a.self,r,s,a),u=l(n,o,c);!1!==a.opts.validateSchema&&a.self.validateSchema(c,!0);const h=n.name("valid");e.subschema({schema:c,schemaPath:i.nil,errSchemaPath:`${a.errSchemaPath}/${o}`,topSchemaRef:u,compositeRule:!0},h),e.pass(h,(()=>e.error(!0)))},t.funcKeywordCode=function(e,t){var n;const{gen:c,keyword:u,schema:h,parentSchema:d,$data:p,it:m}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(m,t);const g=!p&&t.compile?t.compile.call(m.self,h,d,m):t.validate,f=l(c,u,g),y=c.let("valid");function b(n=(t.async?i._`await `:i.nil)){const s=m.opts.passContext?o.default.this:o.default.self,a=!("compile"in t&&!p||!1===t.schema);c.assign(y,i._`${n}${(0,r.callValidateCode)(e,f,s,a)}`,t.modifying)}function v(e){var n;c.if((0,i.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,(function(){if(!1===t.errors)b(),t.modifying&&a(e),v((()=>e.error()));else{const n=t.async?function(){const e=c.let("ruleErrs",null);return c.try((()=>b(i._`await `)),(t=>c.assign(y,!1).if(i._`${t} instanceof ${m.ValidationError}`,(()=>c.assign(e,i._`${t}.errors`)),(()=>c.throw(t))))),e}():function(){const e=i._`${f}.errors`;return c.assign(e,null),b(i.nil),e}();t.modifying&&a(e),v((()=>function(e,t){const{gen:n}=e;n.if(i._`Array.isArray(${t})`,(()=>{n.assign(o.default.vErrors,i._`${o.default.vErrors} === null ? ${t} : ${o.default.vErrors}.concat(${t})`).assign(o.default.errors,i._`${o.default.vErrors}.length`),(0,s.extendErrors)(e)}),(()=>e.error()))}(e,n)))}})),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some((t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e))},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:i},o,r){if(Array.isArray(o.keyword)?!o.keyword.includes(r):o.keyword!==r)throw new Error("ajv implementation error");const s=o.dependencies;if(null==s?void 0:s.some((t=>!Object.prototype.hasOwnProperty.call(e,t))))throw new Error(`parent schema must have dependencies of ${r}: ${s.join(",")}`);if(o.validateSchema&&!o.validateSchema(e[r])){const e=`keyword "${r}" value is invalid at path "${i}": `+n.errorsText(o.validateSchema.errors);if("log"!==t.validateSchema)throw new Error(e);n.logger.error(e)}}},4495:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendSubschemaMode=t.extendSubschemaData=t.getSubschema=void 0;const i=n(9029),o=n(4227);t.getSubschema=function(e,{keyword:t,schemaProp:n,schema:r,schemaPath:s,errSchemaPath:a,topSchemaRef:l}){if(void 0!==t&&void 0!==r)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==t){const r=e.schema[t];return void 0===n?{schema:r,schemaPath:i._`${e.schemaPath}${(0,i.getProperty)(t)}`,errSchemaPath:`${e.errSchemaPath}/${t}`}:{schema:r[n],schemaPath:i._`${e.schemaPath}${(0,i.getProperty)(t)}${(0,i.getProperty)(n)}`,errSchemaPath:`${e.errSchemaPath}/${t}/${(0,o.escapeFragment)(n)}`}}if(void 0!==r){if(void 0===s||void 0===a||void 0===l)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:r,schemaPath:s,topSchemaRef:l,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},t.extendSubschemaData=function(e,t,{dataProp:n,dataPropType:r,data:s,dataTypes:a,propertyName:l}){if(void 0!==s&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:c}=t;if(void 0!==n){const{errorPath:s,dataPathArr:a,opts:l}=t;u(c.let("data",i._`${t.data}${(0,i.getProperty)(n)}`,!0)),e.errorPath=i.str`${s}${(0,o.getErrorPath)(n,r,l.jsPropertySyntax)}`,e.parentDataProperty=i._`${n}`,e.dataPathArr=[...a,e.parentDataProperty]}function u(n){e.data=n,e.dataLevel=t.dataLevel+1,e.dataTypes=[],t.definedProperties=new Set,e.parentData=t.data,e.dataNames=[...t.dataNames,n]}void 0!==s&&(u(s instanceof i.Name?s:c.let("data",s,!0)),void 0!==l&&(e.propertyName=l)),a&&(e.dataTypes=a)},t.extendSubschemaMode=function(e,{jtdDiscriminator:t,jtdMetadata:n,compositeRule:i,createErrors:o,allErrors:r}){void 0!==i&&(e.compositeRule=i),void 0!==o&&(e.createErrors=o),void 0!==r&&(e.allErrors=r),e.jtdDiscriminator=t,e.jtdMetadata=n}},4042:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var i=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return i.KeywordCxt}});var o=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return o._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return o.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return o.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return o.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return o.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return o.CodeGen}});const r=n(3558),s=n(4551),a=n(396),l=n(3835),c=n(9029),u=n(6939),h=n(208),d=n(4227),p=n(3837),m=n(5944),g=(e,t)=>new RegExp(e,t);g.code="new RegExp";const f=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},v={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'};function w(e){var t,n,i,o,r,s,a,l,c,u,h,d,p,f,y,b,v,w,C,S,A,x,M,E,T;const _=e.strict,I=null===(t=e.code)||void 0===t?void 0:t.optimize,L=!0===I||void 0===I?1:I||0,N=null!==(i=null===(n=e.code)||void 0===n?void 0:n.regExp)&&void 0!==i?i:g,P=null!==(o=e.uriResolver)&&void 0!==o?o:m.default;return{strictSchema:null===(s=null!==(r=e.strictSchema)&&void 0!==r?r:_)||void 0===s||s,strictNumbers:null===(l=null!==(a=e.strictNumbers)&&void 0!==a?a:_)||void 0===l||l,strictTypes:null!==(u=null!==(c=e.strictTypes)&&void 0!==c?c:_)&&void 0!==u?u:"log",strictTuples:null!==(d=null!==(h=e.strictTuples)&&void 0!==h?h:_)&&void 0!==d?d:"log",strictRequired:null!==(f=null!==(p=e.strictRequired)&&void 0!==p?p:_)&&void 0!==f&&f,code:e.code?{...e.code,optimize:L,regExp:N}:{optimize:L,regExp:N},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:200,loopEnum:null!==(b=e.loopEnum)&&void 0!==b?b:200,meta:null===(v=e.meta)||void 0===v||v,messages:null===(w=e.messages)||void 0===w||w,inlineRefs:null===(C=e.inlineRefs)||void 0===C||C,schemaId:null!==(S=e.schemaId)&&void 0!==S?S:"$id",addUsedSchema:null===(A=e.addUsedSchema)||void 0===A||A,validateSchema:null===(x=e.validateSchema)||void 0===x||x,validateFormats:null===(M=e.validateFormats)||void 0===M||M,unicodeRegExp:null===(E=e.unicodeRegExp)||void 0===E||E,int32range:null===(T=e.int32range)||void 0===T||T,uriResolver:P}}class C{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...w(e)};const{es5:t,lines:n}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:t,lines:n}),this.logger=function(e){if(!1===e)return _;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const i=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),S.call(this,b,e,"NOT SUPPORTED"),S.call(this,v,e,"DEPRECATED","warn"),this._metaOpts=T.call(this),e.formats&&M.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&E.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),x.call(this),e.validateFormats=i}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let i=p;"id"===n&&(i={...p},i.id=i.$id,delete i.$id),t&&e&&this.addMetaSchema(i,i[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const i=n(t);return"$async"in n||(this.errors=n.errors),i}compile(e,t){const n=this._addSchema(e,t);return n.validate||this._compileSchemaEnv(n)}compileAsync(e,t){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return i.call(this,e,t);async function i(e,t){await o.call(this,e.$schema);const n=this._addSchema(e,t);return n.validate||r.call(this,n)}async function o(e){e&&!this.getSchema(e)&&await i.call(this,{$ref:e},!0)}async function r(e){try{return this._compileSchemaEnv(e)}catch(t){if(!(t instanceof s.default))throw t;return a.call(this,t),await l.call(this,t.missingSchema),r.call(this,e)}}function a({missingSchema:e,missingRef:t}){if(this.refs[e])throw new Error(`AnySchema ${e} is loaded but ${t} cannot be resolved`)}async function l(e){const n=await c.call(this,e);this.refs[e]||await o.call(this,n.$schema),this.refs[e]||this.addSchema(n,e,t)}async function c(e){const t=this._loading[e];if(t)return t;try{return await(this._loading[e]=n(e))}finally{delete this._loading[e]}}}addSchema(e,t,n,i=this.opts.validateSchema){if(Array.isArray(e)){for(const t of e)this.addSchema(t,void 0,n,i);return this}let o;if("object"==typeof e){const{schemaId:t}=this.opts;if(o=e[t],void 0!==o&&"string"!=typeof o)throw new Error(`schema ${t} must be string`)}return t=(0,u.normalizeId)(t||o),this._checkUnique(t),this.schemas[t]=this._addSchema(e,n,t,i,!0),this}addMetaSchema(e,t,n=this.opts.validateSchema){return this.addSchema(e,t,!0,n),this}validateSchema(e,t){if("boolean"==typeof e)return!0;let n;if(n=e.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const i=this.validate(n,e);if(!i&&t){const e="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(e);this.logger.error(e)}return i}getSchema(e){let t;for(;"string"==typeof(t=A.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,i=new l.SchemaEnv({schema:{},schemaId:n});if(t=l.resolveSchema.call(this,i,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=A.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,u.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof t&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),t.keyword=n);else{if("object"!=typeof e||void 0!==t)throw new Error("invalid addKeywords parameters");if(n=(t=e).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if(L.call(this,n,t),!t)return(0,d.eachItem)(n,(e=>N.call(this,e))),this;R.call(this,t);const i={...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)};return(0,d.eachItem)(n,0===i.type.length?e=>N.call(this,e,i):e=>i.type.forEach((t=>N.call(this,e,i,t)))),this}getKeyword(e){const t=this.RULES.all[e];return"object"==typeof t?t.definition:!!t}removeKeyword(e){const{RULES:t}=this;delete t.keywords[e],delete t.all[e];for(const n of t.rules){const t=n.rules.findIndex((t=>t.keyword===e));t>=0&&n.rules.splice(t,1)}return this}addFormat(e,t){return"string"==typeof t&&(t=new RegExp(t)),this.formats[e]=t,this}errorsText(e=this.errors,{separator:t=", ",dataVar:n="data"}={}){return e&&0!==e.length?e.map((e=>`${n}${e.instancePath} ${e.message}`)).reduce(((e,n)=>e+t+n)):"No errors"}$dataMetaSchema(e,t){const n=this.RULES.all;e=JSON.parse(JSON.stringify(e));for(const i of t){const t=i.split("/").slice(1);let o=e;for(const e of t)o=o[e];for(const e in n){const t=n[e];if("object"!=typeof t)continue;const{$data:i}=t.definition,r=o[e];i&&r&&(o[e]=O(r))}}return e}_removeAllSchemas(e,t){for(const n in e){const i=e[n];t&&!t.test(n)||("string"==typeof i?delete e[n]:i&&!i.meta&&(this._cache.delete(i.schema),delete e[n]))}}_addSchema(e,t,n,i=this.opts.validateSchema,o=this.opts.addUsedSchema){let r;const{schemaId:s}=this.opts;if("object"==typeof e)r=e[s];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof e)throw new Error("schema must be object or boolean")}let a=this._cache.get(e);if(void 0!==a)return a;n=(0,u.normalizeId)(r||n);const c=u.getSchemaRefs.call(this,e,n);return a=new l.SchemaEnv({schema:e,schemaId:s,meta:t,baseId:n,localRefs:c}),this._cache.set(a.schema,a),o&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),i&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):l.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,e)}finally{this.opts=t}}}function S(e,t,n,i="error"){for(const o in e){const r=o;r in t&&this.logger[i](`${n}: option ${o}. ${e[r]}`)}}function A(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function x(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function M(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function E(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const n=e[t];n.keyword||(n.keyword=t),this.addKeyword(n)}}}function T(){const e={...this.opts};for(const t of f)delete e[t];return e}C.ValidationError=r.default,C.MissingRefError=s.default,t.default=C;const _={log(){},warn(){},error(){}},I=/^[a-z_$][a-z0-9_$:-]*$/i;function L(e,t){const{RULES:n}=this;if((0,d.eachItem)(e,(e=>{if(n.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!I.test(e))throw new Error(`Keyword ${e} has invalid name`)})),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function N(e,t,n){var i;const o=null==t?void 0:t.post;if(n&&o)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:r}=this;let s=o?r.post:r.rules.find((({type:e})=>e===n));if(s||(s={type:n,rules:[]},r.rules.push(s)),r.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)}};t.before?P.call(this,s,a,t.before):s.rules.push(a),r.all[e]=a,null===(i=t.implements)||void 0===i||i.forEach((e=>this.addKeyword(e)))}function P(e,t,n){const i=e.rules.findIndex((e=>e.keyword===n));i>=0?e.rules.splice(i,0,t):(e.rules.push(t),this.logger.warn(`rule ${n} is not defined`))}function R(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=O(t)),e.validateSchema=this.compile(t,!0))}const $={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function O(e){return{anyOf:[e,$]}}},9572:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1678),o=n(7216),r=n(9547),s=n(8226),a=n(518),l=n(4588),c=n(5707),u=n(7082),h=["/properties"];t.default=function(e){return[i,o,r,s,a,t(this,l),c,t(this,u)].forEach((e=>this.addMetaSchema(e,void 0,!1))),this;function t(t,n){return e?t.$dataMetaSchema(n,h):n}}},6250:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2017);i.code='require("ajv/dist/runtime/equal").default',t.default=i},3853:(e,t)=>{"use strict";function n(e){const t=e.length;let n,i=0,o=0;for(;o<t;)i++,n=e.charCodeAt(o++),n>=55296&&n<=56319&&o<t&&(n=e.charCodeAt(o),56320==(64512&n)&&o++);return i}Object.defineProperty(t,"__esModule",{value:!0}),t.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},5944:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(8343);i.code='require("ajv/dist/runtime/uri").default',t.default=i},3558:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});class n extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=n},5457:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const i=n(9029),o=n(4227),r={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{parentSchema:t,it:n}=e,{items:i}=t;Array.isArray(i)?s(e,i):(0,o.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function s(e,t){const{gen:n,schema:r,data:s,keyword:a,it:l}=e;l.items=!0;const c=n.const("len",i._`${s}.length`);if(!1===r)e.setParams({len:t.length}),e.pass(i._`${c} <= ${t.length}`);else if("object"==typeof r&&!(0,o.alwaysValidSchema)(l,r)){const r=n.var("valid",i._`${c} <= ${t.length}`);n.if((0,i.not)(r),(()=>function(r){n.forRange("i",t.length,c,(t=>{e.subschema({keyword:a,dataProp:t,dataPropType:o.Type.Num},r),l.allErrors||n.if((0,i.not)(r),(()=>n.break()))}))}(r))),e.ok(r)}}t.validateAdditionalItems=s,t.default=r},8660:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(2023),s=n(4227),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>o._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:n,parentSchema:a,data:l,errsCount:c,it:u}=e;if(!c)throw new Error("ajv implementation error");const{allErrors:h,opts:d}=u;if(u.props=!0,"all"!==d.removeAdditional&&(0,s.alwaysValidSchema)(u,n))return;const p=(0,i.allSchemaProperties)(a.properties),m=(0,i.allSchemaProperties)(a.patternProperties);function g(e){t.code(o._`delete ${l}[${e}]`)}function f(i){if("all"===d.removeAdditional||d.removeAdditional&&!1===n)g(i);else{if(!1===n)return e.setParams({additionalProperty:i}),e.error(),void(h||t.break());if("object"==typeof n&&!(0,s.alwaysValidSchema)(u,n)){const n=t.name("valid");"failing"===d.removeAdditional?(y(i,n,!1),t.if((0,o.not)(n),(()=>{e.reset(),g(i)}))):(y(i,n),h||t.if((0,o.not)(n),(()=>t.break())))}}}function y(t,n,i){const o={keyword:"additionalProperties",dataProp:t,dataPropType:s.Type.Str};!1===i&&Object.assign(o,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(o,n)}t.forIn("key",l,(n=>{p.length||m.length?t.if(function(n){let r;if(p.length>8){const e=(0,s.schemaRefOrVal)(u,a.properties,"properties");r=(0,i.isOwnProperty)(t,e,n)}else r=p.length?(0,o.or)(...p.map((e=>o._`${n} === ${e}`))):o.nil;return m.length&&(r=(0,o.or)(r,...m.map((t=>o._`${(0,i.usePattern)(e,t)}.test(${n})`)))),(0,o.not)(r)}(n),(()=>f(n))):f(n)})),e.ok(o._`${c} === ${r.default.errors}`)}};t.default=a},5844:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:n,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");const r=t.name("valid");n.forEach(((t,n)=>{if((0,i.alwaysValidSchema)(o,t))return;const s=e.subschema({keyword:"allOf",schemaProp:n},r);e.ok(r),e.mergeEvaluated(s)}))}};t.default=o},6505:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=i},2661:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?i.str`must contain at least ${e} valid item(s)`:i.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?i._`{minContains: ${e}}`:i._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:r,data:s,it:a}=e;let l,c;const{minContains:u,maxContains:h}=r;a.opts.next?(l=void 0===u?1:u,c=h):l=1;const d=t.const("len",i._`${s}.length`);if(e.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,o.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,o.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,o.alwaysValidSchema)(a,n)){let t=i._`${d} >= ${l}`;return void 0!==c&&(t=i._`${t} && ${d} <= ${c}`),void e.pass(t)}a.items=!0;const p=t.name("valid");function m(){const e=t.name("_valid"),n=t.let("count",0);g(e,(()=>t.if(e,(()=>function(e){t.code(i._`${e}++`),void 0===c?t.if(i._`${e} >= ${l}`,(()=>t.assign(p,!0).break())):(t.if(i._`${e} > ${c}`,(()=>t.assign(p,!1).break())),1===l?t.assign(p,!0):t.if(i._`${e} >= ${l}`,(()=>t.assign(p,!0))))}(n)))))}function g(n,i){t.forRange("i",0,d,(t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:o.Type.Num,compositeRule:!0},n),i()}))}void 0===c&&1===l?g(p,(()=>t.if(p,(()=>t.break())))):0===l?(t.let(p,!0),void 0!==c&&t.if(i._`${s}.length > 0`,m)):(t.let(p,!1),m()),e.result(p,(()=>e.reset()))}};t.default=r},3025:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const i=n(9029),o=n(4227),r=n(5765);t.error={message:({params:{property:e,depsCount:t,deps:n}})=>{const o=1===t?"property":"properties";return i.str`must have ${o} ${n} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:n,missingProperty:o}})=>i._`{property: ${e},
     missingProperty: ${o},
-    depsCount: ${e},
-    deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:e.error,code(t){const[e,n]=function({schema:t}){const e={},n={};for(const i in t)"__proto__"!==i&&((Array.isArray(t[i])?e:n)[i]=t[i]);return[e,n]}(t);a(t,e),l(t,n)}};function a(t,e=t.schema){const{gen:n,data:o,it:s}=t;if(0===Object.keys(e).length)return;const a=n.let("missing");for(const l in e){const c=e[l];if(0===c.length)continue;const h=(0,r.propertyInData)(n,o,l,s.opts.ownProperties);t.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(h,(()=>{for(const e of c)(0,r.checkReportMissingProp)(t,e)})):(n.if(i._`${h} && (${(0,r.checkMissingProp)(t,c,a)})`),(0,r.reportMissingProp)(t,a),n.else())}}function l(t,e=t.schema){const{gen:n,data:i,keyword:s,it:a}=t,l=n.name("valid");for(const c in e)(0,o.alwaysValidSchema)(a,e[c])||(n.if((0,r.propertyInData)(n,i,c,a.opts.ownProperties),(()=>{const e=t.subschema({keyword:s,schemaProp:c},l);t.mergeValidEvaluated(e,l)}),(()=>n.var(l,!0))),t.ok(l))}e.validatePropertyDeps=a,e.validateSchemaDeps=l,e.default=s},4845:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentSchemas",type:"object",schemaType:"object",code:t=>(0,i.validateSchemaDeps)(t)};e.default=o},1239:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:t})=>i.str`must match "${t.ifClause}" schema`,params:({params:t})=>i._`{failingKeyword: ${t.ifClause}}`},code(t){const{gen:e,parentSchema:n,it:r}=t;void 0===n.then&&void 0===n.else&&(0,o.checkStrictMode)(r,'"if" without "then" and "else" is ignored');const a=s(r,"then"),l=s(r,"else");if(!a&&!l)return;const c=e.let("valid",!0),h=e.name("_valid");if(function(){const e=t.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},h);t.mergeEvaluated(e)}(),t.reset(),a&&l){const n=e.let("ifClause");t.setParams({ifClause:n}),e.if(h,u("then",n),u("else",n))}else a?e.if(h,u("then")):e.if((0,i.not)(h),u("else"));function u(n,o){return()=>{const r=t.subschema({keyword:n},h);e.assign(c,h),t.mergeValidEvaluated(r,c),o?e.assign(o,i._`${n}`):t.setParams({ifClause:n})}}t.pass(c,(()=>t.error(!0)))}};function s(t,e){const n=t.schema[e];return void 0!==n&&!(0,o.alwaysValidSchema)(t,n)}e.default=r},6378:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5457),o=n(5354),r=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(2094),h=n(8660),u=n(117),d=n(5333),p=n(7923),m=n(6505),f=n(6163),g=n(5844),y=n(1239),b=n(4426);e.default=function(t=!1){const e=[p.default,m.default,f.default,g.default,y.default,b.default,c.default,h.default,l.default,u.default,d.default];return t?e.push(o.default,s.default):e.push(i.default,r.default),e.push(a.default),e}},494:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateTuple=void 0;const i=n(9029),o=n(4227),r=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(t){const{schema:e,it:n}=t;if(Array.isArray(e))return a(t,"additionalItems",e);n.items=!0,(0,o.alwaysValidSchema)(n,e)||t.ok((0,r.validateArray)(t))}};function a(t,e,n=t.schema){const{gen:r,parentSchema:s,data:a,keyword:l,it:c}=t;!function(t){const{opts:i,errSchemaPath:r}=c,s=n.length,a=s===t.minItems&&(s===t.maxItems||!1===t[e]);if(i.strictTuples&&!a){const t=`"${l}" is ${s}-tuple, but minItems or maxItems/${e} are not specified or different at path "${r}"`;(0,o.checkStrictMode)(c,t,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=o.mergeEvaluated.items(r,n.length,c.items));const h=r.name("valid"),u=r.const("len",i._`${a}.length`);n.forEach(((e,n)=>{(0,o.alwaysValidSchema)(c,e)||(r.if(i._`${u} > ${n}`,(()=>t.subschema({keyword:l,schemaProp:n,dataProp:n},h))),t.ok(h))}))}e.validateTuple=a,e.default=s},3966:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{schema:e,parentSchema:n,it:i}=t,{prefixItems:a}=n;i.items=!0,(0,o.alwaysValidSchema)(i,e)||(a?(0,s.validateAdditionalItems)(t,a):t.ok((0,r.validateArray)(t)))}};e.default=a},7923:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),o={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(t){const{gen:e,schema:n,it:o}=t;if((0,i.alwaysValidSchema)(o,n))return void t.fail();const r=e.name("valid");t.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},r),t.failResult(r,(()=>t.reset()),(()=>t.error()))},error:{message:"must NOT be valid"}};e.default=o},6163:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:t})=>i._`{passingSchemas: ${t.passing}}`},code(t){const{gen:e,schema:n,parentSchema:r,it:s}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&r.discriminator)return;const a=n,l=e.let("valid",!1),c=e.let("passing",null),h=e.name("_valid");t.setParams({passing:c}),e.block((function(){a.forEach(((n,r)=>{let a;(0,o.alwaysValidSchema)(s,n)?e.var(h,!0):a=t.subschema({keyword:"oneOf",schemaProp:r,compositeRule:!0},h),r>0&&e.if(i._`${h} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${r}]`).else(),e.if(h,(()=>{e.assign(l,!0),e.assign(c,r),a&&t.mergeEvaluated(a,i.Name)}))}))})),t.result(l,(()=>t.reset()),(()=>t.error(!0)))}};e.default=r},5333:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(t){const{gen:e,schema:n,data:a,parentSchema:l,it:c}=t,{opts:h}=c,u=(0,i.allSchemaProperties)(n),d=u.filter((t=>(0,r.alwaysValidSchema)(c,n[t])));if(0===u.length||d.length===u.length&&(!c.opts.unevaluated||!0===c.props))return;const p=h.strictSchema&&!h.allowMatchingProperties&&l.properties,m=e.name("valid");!0===c.props||c.props instanceof o.Name||(c.props=(0,s.evaluatedPropsToName)(e,c.props));const{props:f}=c;function g(t){for(const e in p)new RegExp(t).test(e)&&(0,r.checkStrictMode)(c,`property ${e} matches pattern ${t} (use allowMatchingProperties)`)}function y(n){e.forIn("key",a,(r=>{e.if(o._`${(0,i.usePattern)(t,n)}.test(${r})`,(()=>{const i=d.includes(n);i||t.subschema({keyword:"patternProperties",schemaProp:n,dataProp:r,dataPropType:s.Type.Str},m),c.opts.unevaluated&&!0!==f?e.assign(o._`${f}[${r}]`,!0):i||c.allErrors||e.if((0,o.not)(m),(()=>e.break()))}))}))}!function(){for(const t of u)p&&g(t),c.allErrors?y(t):(e.var(m,!0),y(t),e.if(m))}()}};e.default=a},5354:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(494),o={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:t=>(0,i.validateTuple)(t,"items")};e.default=o},117:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2586),o=n(5765),r=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(t){const{gen:e,schema:n,parentSchema:a,data:l,it:c}=t;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const h=(0,o.allSchemaProperties)(n);for(const t of h)c.definedProperties.add(t);c.opts.unevaluated&&h.length&&!0!==c.props&&(c.props=r.mergeEvaluated.props(e,(0,r.toHash)(h),c.props));const u=h.filter((t=>!(0,r.alwaysValidSchema)(c,n[t])));if(0===u.length)return;const d=e.name("valid");for(const n of u)p(n)?m(n):(e.if((0,o.propertyInData)(e,l,n,c.opts.ownProperties)),m(n),c.allErrors||e.else().var(d,!0),e.endIf()),t.it.definedProperties.add(n),t.ok(d);function p(t){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[t].default}function m(e){t.subschema({keyword:"properties",schemaProp:e,dataProp:e},d)}}};e.default=a},2094:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:t})=>i._`{propertyName: ${t.propertyName}}`},code(t){const{gen:e,schema:n,data:r,it:s}=t;if((0,o.alwaysValidSchema)(s,n))return;const a=e.name("valid");e.forIn("key",r,(n=>{t.setParams({propertyName:n}),t.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),e.if((0,i.not)(a),(()=>{t.error(!0),s.allErrors||e.break()}))})),t.ok(a)}};e.default=r},4426:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),o={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:t,parentSchema:e,it:n}){void 0===e.if&&(0,i.checkStrictMode)(n,`"${t}" without "if" is ignored`)}};e.default=o},5765:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateUnion=e.validateArray=e.usePattern=e.callValidateCode=e.schemaProperties=e.allSchemaProperties=e.noPropertyInData=e.propertyInData=e.isOwnProperty=e.hasPropFunc=e.reportMissingProp=e.checkMissingProp=e.checkReportMissingProp=void 0;const i=n(9029),o=n(4227),r=n(2023),s=n(4227);function a(t){return t.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(t,e,n){return i._`${a(t)}.call(${e}, ${n})`}function c(t,e,n,o){const r=i._`${e}${(0,i.getProperty)(n)} === undefined`;return o?(0,i.or)(r,(0,i.not)(l(t,e,n))):r}function h(t){return t?Object.keys(t).filter((t=>"__proto__"!==t)):[]}e.checkReportMissingProp=function(t,e){const{gen:n,data:o,it:r}=t;n.if(c(n,o,e,r.opts.ownProperties),(()=>{t.setParams({missingProperty:i._`${e}`},!0),t.error()}))},e.checkMissingProp=function({gen:t,data:e,it:{opts:n}},o,r){return(0,i.or)(...o.map((o=>(0,i.and)(c(t,e,o,n.ownProperties),i._`${r} = ${o}`))))},e.reportMissingProp=function(t,e){t.setParams({missingProperty:e},!0),t.error()},e.hasPropFunc=a,e.isOwnProperty=l,e.propertyInData=function(t,e,n,o){const r=i._`${e}${(0,i.getProperty)(n)} !== undefined`;return o?i._`${r} && ${l(t,e,n)}`:r},e.noPropertyInData=c,e.allSchemaProperties=h,e.schemaProperties=function(t,e){return h(e).filter((n=>!(0,o.alwaysValidSchema)(t,e[n])))},e.callValidateCode=function({schemaCode:t,data:e,it:{gen:n,topSchemaRef:o,schemaPath:s,errorPath:a},it:l},c,h,u){const d=u?i._`${t}, ${e}, ${o}${s}`:e,p=[[r.default.instancePath,(0,i.strConcat)(r.default.instancePath,a)],[r.default.parentData,l.parentData],[r.default.parentDataProperty,l.parentDataProperty],[r.default.rootData,r.default.rootData]];l.opts.dynamicRef&&p.push([r.default.dynamicAnchors,r.default.dynamicAnchors]);const m=i._`${d}, ${n.object(...p)}`;return h!==i.nil?i._`${c}.call(${h}, ${m})`:i._`${c}(${m})`};const u=i._`new RegExp`;e.usePattern=function({gen:t,it:{opts:e}},n){const o=e.unicodeRegExp?"u":"",{regExp:r}=e.code,a=r(n,o);return t.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===r.code?u:(0,s.useFunc)(t,r)}(${n}, ${o})`})},e.validateArray=function(t){const{gen:e,data:n,keyword:r,it:s}=t,a=e.name("valid");if(s.allErrors){const t=e.let("valid",!0);return l((()=>e.assign(t,!1))),t}return e.var(a,!0),l((()=>e.break())),a;function l(s){const l=e.const("len",i._`${n}.length`);e.forRange("i",0,l,(n=>{t.subschema({keyword:r,dataProp:n,dataPropType:o.Type.Num},a),e.if((0,i.not)(a),s)}))}},e.validateUnion=function(t){const{gen:e,schema:n,keyword:r,it:s}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((t=>(0,o.alwaysValidSchema)(s,t)))&&!s.opts.unevaluated)return;const a=e.let("valid",!1),l=e.name("_valid");e.block((()=>n.forEach(((n,o)=>{const s=t.subschema({keyword:r,schemaProp:o,compositeRule:!0},l);e.assign(a,i._`${a} || ${l}`),t.mergeValidEvaluated(s,l)||e.if((0,i.not)(a))})))),t.result(a,(()=>t.reset()),(()=>t.error(!0)))}},3463:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};e.default=n},2128:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3463),o=n(3693),r=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,o.default];e.default=r},3693:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.callRef=e.getValidate=void 0;const i=n(4551),o=n(5765),r=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(t){const{gen:e,schema:n,it:o}=t,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:p}=o,{root:m}=l;if(("#"===n||"#/"===n)&&s===m.baseId)return function(){if(l===m)return u(t,c,l,l.$async);const n=e.scopeValue("root",{ref:m});return u(t,r._`${n}.validate`,m,m.$async)}();const f=a.resolveRef.call(p,m,s,n);if(void 0===f)throw new i.default(o.opts.uriResolver,s,n);return f instanceof a.SchemaEnv?function(e){const n=h(t,e);u(t,n,e,e.$async)}(f):function(i){const o=e.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,r.stringify)(i)}:{ref:i}),s=e.name("valid"),a=t.subschema({schema:i,dataTypes:[],schemaPath:r.nil,topSchemaRef:o,errSchemaPath:n},s);t.mergeEvaluated(a),t.ok(s)}(f)}};function h(t,e){const{gen:n}=t;return e.validate?n.scopeValue("validate",{ref:e.validate}):r._`${n.scopeValue("wrapper",{ref:e})}.validate`}function u(t,e,n,i){const{gen:a,it:c}=t,{allErrors:h,schemaEnv:u,opts:d}=c,p=d.passContext?s.default.this:r.nil;function m(t){const e=r._`${t}.errors`;a.assign(s.default.vErrors,r._`${s.default.vErrors} === null ? ${e} : ${s.default.vErrors}.concat(${e})`),a.assign(s.default.errors,r._`${s.default.vErrors}.length`)}function f(t){var e;if(!c.opts.unevaluated)return;const i=null===(e=null==n?void 0:n.validate)||void 0===e?void 0:e.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const e=a.var("props",r._`${t}.evaluated.props`);c.props=l.mergeEvaluated.props(a,e,c.props,r.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const e=a.var("items",r._`${t}.evaluated.items`);c.items=l.mergeEvaluated.items(a,e,c.items,r.Name)}}i?function(){if(!u.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(r._`await ${(0,o.callValidateCode)(t,e,p)}`),f(e),h||a.assign(n,!0)}),(t=>{a.if(r._`!(${t} instanceof ${c.ValidationError})`,(()=>a.throw(t))),m(t),h||a.assign(n,!1)})),t.ok(n)}():t.result((0,o.callValidateCode)(t,e,p),(()=>f(e)),(()=>m(e)))}e.getValidate=h,e.callRef=u,e.default=c},6653:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(7652),r=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:t,tagName:e}})=>t===o.DiscrError.Tag?`tag "${e}" must be string`:`value of tag "${e}" must be in oneOf`,params:({params:{discrError:t,tag:e,tagName:n}})=>i._`{error: ${t}, tag: ${n}, tagValue: ${e}}`},code(t){const{gen:e,data:n,schema:l,parentSchema:c,it:h}=t,{oneOf:u}=c;if(!h.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!u)throw new Error("discriminator: requires oneOf keyword");const p=e.let("valid",!1),m=e.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function f(n){const o=e.name("valid"),r=t.subschema({keyword:"oneOf",schemaProp:n},o);return t.mergeEvaluated(r,i.Name),o}e.if(i._`typeof ${m} == "string"`,(()=>function(){const n=function(){var t;const e={},n=o(c);let i=!0;for(let e=0;e<u.length;e++){let c=u[e];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,h.self.RULES)){const t=c.$ref;if(c=r.resolveRef.call(h.self,h.schemaEnv.root,h.baseId,t),c instanceof r.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(h.opts.uriResolver,h.baseId,t)}const p=null===(t=null==c?void 0:c.properties)||void 0===t?void 0:t[d];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||o(c)),l(p,e)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return e;function o({required:t}){return Array.isArray(t)&&t.includes(d)}function l(t,e){if(t.const)p(t.const,e);else{if(!t.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of t.enum)p(n,e)}}function p(t,n){if("string"!=typeof t||t in e)throw new Error(`discriminator: "${d}" values must be unique strings`);e[t]=n}}();e.if(!1);for(const t in n)e.elseIf(i._`${m} === ${t}`),e.assign(p,f(n[t]));e.else(),t.error(!1,{discrError:o.DiscrError.Mapping,tag:m,tagName:d}),e.endIf()}()),(()=>t.error(!1,{discrError:o.DiscrError.Tag,tag:m,tagName:d}))),t.ok(p)}};e.default=l},7652:(t,e)=>{"use strict";var n;Object.defineProperty(e,"__esModule",{value:!0}),e.DiscrError=void 0,function(t){t.Tag="tag",t.Mapping="mapping"}(n||(e.DiscrError=n={}))},6105:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),h=n(9857),u=[s.default,i.default,o.default,(0,r.default)(!0),c.default,h.metadataVocabulary,h.contentVocabulary,a.default,l.default];e.default=u},6144:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(7532),a=n(9857),l=[i.default,o.default,(0,r.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];e.default=l},2476:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.dynamicAnchor=void 0;const i=n(9029),o=n(2023),r=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:t=>l(t,t.schema)};function l(t,e){const{gen:n,it:a}=t;a.schemaEnv.root.dynamicAnchors[e]=!0;const l=i._`${o.default.dynamicAnchors}${(0,i.getProperty)(e)}`,c="#"===a.errSchemaPath?a.validateName:function(t){const{schemaEnv:e,schema:n,self:i}=t.it,{root:o,baseId:a,localRefs:l,meta:c}=e.root,{schemaId:h}=i.opts,u=new r.SchemaEnv({schema:n,schemaId:h,root:o,baseId:a,localRefs:l,meta:c});return r.compileSchema.call(i,u),(0,s.getValidate)(t,u)}(t);n.if(i._`!${l}`,(()=>n.assign(l,c)))}e.dynamicAnchor=l,e.default=a},3252:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.dynamicRef=void 0;const i=n(9029),o=n(2023),r=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:t=>a(t,t.schema)};function a(t,e){const{gen:n,keyword:s,it:a}=t;if("#"!==e[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=e.slice(1);if(a.allErrors)c();else{const e=n.let("valid",!1);c(e),t.ok(e)}function c(t){if(a.schemaEnv.root.dynamicAnchors[l]){const e=n.let("_v",i._`${o.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(e,h(e,t),h(a.validateName,t))}else h(a.validateName,t)()}function h(e,i){return i?()=>n.block((()=>{(0,r.callRef)(t,e),n.let(i,!0)})):()=>(0,r.callRef)(t,e)}}e.dynamicRef=a,e.default=s},5520:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2476),o=n(3252),r=n(2721),s=n(3799),a=[i.default,o.default,r.default,s.default];e.default=a},2721:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2476),o=n(4227),r={keyword:"$recursiveAnchor",schemaType:"boolean",code(t){t.schema?(0,i.dynamicAnchor)(t,""):(0,o.checkStrictMode)(t.it,"$recursiveAnchor: false is ignored")}};e.default=r},3799:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3252),o={keyword:"$recursiveRef",schemaType:"string",code:t=>(0,i.dynamicRef)(t,t.schema)};e.default=o},4737:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:t})=>i.str`must match format "${t}"`,params:({schemaCode:t})=>i._`{format: ${t}}`},code(t,e){const{gen:n,data:o,$data:r,schema:s,schemaCode:a,it:l}=t,{opts:c,errSchemaPath:h,schemaEnv:u,self:d}=l;c.validateFormats&&(r?function(){const r=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${r}[${a}]`),l=n.let("fType"),h=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,(()=>n.assign(l,i._`${s}.type || "string"`).assign(h,i._`${s}.validate`)),(()=>n.assign(l,i._`"string"`).assign(h,s))),t.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${h}`,function(){const t=u.$async?i._`(${s}.async ? await ${h}(${o}) : ${h}(${o}))`:i._`${h}(${o})`,n=i._`(typeof ${h} == "function" ? ${t} : ${h}.test(${o}))`;return i._`${h} && ${h} !== true && ${l} === ${e} && !${n}`}()))}():function(){const r=d.formats[s];if(!r)return void function(){if(!1!==c.strictSchema)throw new Error(t());function t(){return`unknown format "${s}" ignored in schema at path "${h}"`}d.logger.warn(t())}();if(!0===r)return;const[a,l,p]=function(t){const e=t instanceof RegExp?(0,i.regexpCode)(t):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,o=n.scopeValue("formats",{key:s,ref:t,code:e});return"object"!=typeof t||t instanceof RegExp?["string",t,o]:[t.type||"string",t.validate,i._`${o}.validate`]}(r);a===e&&t.pass(function(){if("object"==typeof r&&!(r instanceof RegExp)&&r.async){if(!u.$async)throw new Error("async format in sync schema");return i._`await ${p}(${o})`}return"function"==typeof l?i._`${p}(${o})`:i._`${p}.test(${o})`}())}())}};e.default=o},7532:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=[n(4737).default];e.default=i},9857:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.contentVocabulary=e.metadataVocabulary=void 0,e.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],e.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(1846),o=n(4845),r=n(2626),s=[i.default,o.default,r.default];e.default=s},3265:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(392),o=n(3445),r=[i.default,o.default];e.default=r},3445:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{gen:e,schema:n,data:r,it:s}=t,a=s.items||0;if(!0===a)return;const l=e.const("len",i._`${r}.length`);if(!1===n)t.setParams({len:a}),t.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,o.alwaysValidSchema)(s,n)){const n=e.var("valid",i._`${l} <= ${a}`);e.if((0,i.not)(n),(()=>function(n,r){e.forRange("i",r,l,(r=>{t.subschema({keyword:"unevaluatedItems",dataProp:r,dataPropType:o.Type.Num},n),s.allErrors||e.if((0,i.not)(n),(()=>e.break()))}))}(n,a))),t.ok(n)}s.items=!0}};e.default=r},392:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:t})=>i._`{unevaluatedProperty: ${t.unevaluatedProperty}}`},code(t){const{gen:e,schema:n,data:s,errsCount:a,it:l}=t;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:h}=l;function u(r){if(!1===n)return t.setParams({unevaluatedProperty:r}),t.error(),void(c||e.break());if(!(0,o.alwaysValidSchema)(l,n)){const n=e.name("valid");t.subschema({keyword:"unevaluatedProperties",dataProp:r,dataPropType:o.Type.Str},n),c||e.if((0,i.not)(n),(()=>e.break()))}}h instanceof i.Name?e.if(i._`${h} !== true`,(()=>e.forIn("key",s,(t=>e.if(function(t,e){return i._`!${t} || !${t}[${e}]`}(h,t),(()=>u(t))))))):!0!==h&&e.forIn("key",s,(t=>void 0===h?u(t):e.if(function(t,e){const n=[];for(const o in t)!0===t[o]&&n.push(i._`${e} !== ${o}`);return(0,i.and)(...n)}(h,t),(()=>u(t))))),l.props=!0,t.ok(i._`${a} === ${r.default.errors}`)}};e.default=s},7935:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:t})=>i._`{allowedValue: ${t}}`},code(t){const{gen:e,data:n,$data:s,schemaCode:a,schema:l}=t;s||l&&"object"==typeof l?t.fail$data(i._`!${(0,o.useFunc)(e,r.default)}(${n}, ${a})`):t.fail(i._`${l} !== ${n}`)}};e.default=s},1846:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:t=>(0,i.validatePropertyDeps)(t)};e.default=o},8643:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:t})=>i._`{allowedValues: ${t}}`},code(t){const{gen:e,data:n,$data:s,schema:a,schemaCode:l,it:c}=t;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const h=a.length>=c.opts.loopEnum;let u;const d=()=>null!=u?u:u=(0,o.useFunc)(e,r.default);let p;if(h||s)p=e.let("valid"),t.block$data(p,(function(){e.assign(p,!1),e.forOf("v",l,(t=>e.if(i._`${d()}(${n}, ${t})`,(()=>e.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const t=e.const("vSchema",l);p=(0,i.or)(...a.map(((e,o)=>function(t,e){const o=a[e];return"object"==typeof o&&null!==o?i._`${d()}(${n}, ${t}[${e}])`:i._`${n} === ${o}`}(t,o))))}t.pass(p)}};e.default=s},7060:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5882),o=n(3439),r=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),h=n(617),u=n(7935),d=n(8643),p=[i.default,o.default,r.default,s.default,a.default,l.default,c.default,h.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},u.default,d.default];e.default=p},2626:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),o={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:t,parentSchema:e,it:n}){void 0===e.contains&&(0,i.checkStrictMode)(n,`"${t}" without "contains" is ignored`)}};e.default=o},1163:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxItems"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} items`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:o}=t,r="maxItems"===e?i.operators.GT:i.operators.LT;t.fail$data(i._`${n}.length ${r} ${o}`)}};e.default=o},7307:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxLength"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} characters`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:s,it:a}=t,l="maxLength"===e?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,o.useFunc)(t.gen,r.default)}(${n})`;t.fail$data(i._`${c} ${l} ${s}`)}};e.default=s},5882:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o=i.operators,r={maximum:{okStr:"<=",ok:o.LTE,fail:o.GT},minimum:{okStr:">=",ok:o.GTE,fail:o.LT},exclusiveMaximum:{okStr:"<",ok:o.LT,fail:o.GTE},exclusiveMinimum:{okStr:">",ok:o.GT,fail:o.LTE}},s={message:({keyword:t,schemaCode:e})=>i.str`must be ${r[t].okStr} ${e}`,params:({keyword:t,schemaCode:e})=>i._`{comparison: ${r[t].okStr}, limit: ${e}}`},a={keyword:Object.keys(r),type:"number",schemaType:"number",$data:!0,error:s,code(t){const{keyword:e,data:n,schemaCode:o}=t;t.fail$data(i._`${n} ${r[e].fail} ${o} || isNaN(${n})`)}};e.default=a},4486:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxProperties"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} properties`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:o}=t,r="maxProperties"===e?i.operators.GT:i.operators.LT;t.fail$data(i._`Object.keys(${n}).length ${r} ${o}`)}};e.default=o},3439:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),o={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:t})=>i.str`must be multiple of ${t}`,params:({schemaCode:t})=>i._`{multipleOf: ${t}}`},code(t){const{gen:e,data:n,schemaCode:o,it:r}=t,s=r.opts.multipleOfPrecision,a=e.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;t.fail$data(i._`(${o} === 0 || (${a} = ${n}/${o}, ${l}))`)}};e.default=o},422:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),o=n(9029),r={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:t})=>o.str`must match pattern "${t}"`,params:({schemaCode:t})=>o._`{pattern: ${t}}`},code(t){const{data:e,$data:n,schema:r,schemaCode:s,it:a}=t,l=a.opts.unicodeRegExp?"u":"",c=n?o._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(t,r);t.fail$data(o._`!${c}.test(${e})`)}};e.default=r},4003:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:t}})=>o.str`must have required property '${t}'`,params:({params:{missingProperty:t}})=>o._`{missingProperty: ${t}}`},code(t){const{gen:e,schema:n,schemaCode:s,data:a,$data:l,it:c}=t,{opts:h}=c;if(!l&&0===n.length)return;const u=n.length>=h.loopRequired;if(c.allErrors?function(){if(u||l)t.block$data(o.nil,d);else for(const e of n)(0,i.checkReportMissingProp)(t,e)}():function(){const r=e.let("missing");if(u||l){const n=e.let("valid",!0);t.block$data(n,(()=>function(n,r){t.setParams({missingProperty:n}),e.forOf(n,s,(()=>{e.assign(r,(0,i.propertyInData)(e,a,n,h.ownProperties)),e.if((0,o.not)(r),(()=>{t.error(),e.break()}))}),o.nil)}(r,n))),t.ok(n)}else e.if((0,i.checkMissingProp)(t,n,r)),(0,i.reportMissingProp)(t,r),e.else()}(),h.strictRequired){const e=t.parentSchema.properties,{definedProperties:i}=t.it;for(const t of n)if(void 0===(null==e?void 0:e[t])&&!i.has(t)){const e=`required property "${t}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,r.checkStrictMode)(c,e,c.opts.strictRequired)}}function d(){e.forOf("prop",s,(n=>{t.setParams({missingProperty:n}),e.if((0,i.noPropertyInData)(e,a,n,h.ownProperties),(()=>t.error()))}))}}};e.default=s},617:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(208),o=n(9029),r=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:t,j:e}})=>o.str`must NOT have duplicate items (items ## ${e} and ${t} are identical)`,params:({params:{i:t,j:e}})=>o._`{i: ${t}, j: ${e}}`},code(t){const{gen:e,data:n,$data:a,schema:l,parentSchema:c,schemaCode:h,it:u}=t;if(!a&&!l)return;const d=e.let("valid"),p=c.items?(0,i.getSchemaTypes)(c.items):[];function m(r,s){const a=e.name("item"),l=(0,i.checkDataTypes)(p,a,u.opts.strictNumbers,i.DataType.Wrong),c=e.const("indices",o._`{}`);e.for(o._`;${r}--;`,(()=>{e.let(a,o._`${n}[${r}]`),e.if(l,o._`continue`),p.length>1&&e.if(o._`typeof ${a} == "string"`,o._`${a} += "_"`),e.if(o._`typeof ${c}[${a}] == "number"`,(()=>{e.assign(s,o._`${c}[${a}]`),t.error(),e.assign(d,!1).break()})).code(o._`${c}[${a}] = ${r}`)}))}function f(i,a){const l=(0,r.useFunc)(e,s.default),c=e.name("outer");e.label(c).for(o._`;${i}--;`,(()=>e.for(o._`${a} = ${i}; ${a}--;`,(()=>e.if(o._`${l}(${n}[${i}], ${n}[${a}])`,(()=>{t.error(),e.assign(d,!1).break(c)}))))))}t.block$data(d,(function(){const i=e.let("i",o._`${n}.length`),r=e.let("j");t.setParams({i,j:r}),e.assign(d,!0),e.if(o._`${i} > 1`,(()=>(p.length>0&&!p.some((t=>"object"===t||"array"===t))?m:f)(i,r)))}),o._`${h} === false`),t.ok(d)}};e.default=a},5488:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([t.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([t.id,".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}"],sourceRoot:""}]);const a=s},857:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([t.id,".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB;;AAEA;IACI,qBAAqB;AACzB;;AAEA;IACI,4BAA4B;AAChC",sourcesContent:[".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}"],sourceRoot:""}]);const a=s},6369:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([t.id,".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([t.id,".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,WAAW;AACf;;AAEA;IACI,4BAA4B;IAC5B,yBAAyB;IACzB,eAAe;AACnB;;AAEA;GACG,mBAAmB;AACtB;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([t.id,".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,gBAAgB;EAChB,WAAW;;AAEb",sourcesContent:[".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n"],sourceRoot:""}]);const a=s},6314:t=>{"use strict";t.exports=function(t){var e=[];return e.toString=function(){return this.map((function(e){var n="",i=void 0!==e[5];return e[4]&&(n+="@supports (".concat(e[4],") {")),e[2]&&(n+="@media ".concat(e[2]," {")),i&&(n+="@layer".concat(e[5].length>0?" ".concat(e[5]):""," {")),n+=t(e),i&&(n+="}"),e[2]&&(n+="}"),e[4]&&(n+="}"),n})).join("")},e.i=function(t,n,i,o,r){"string"==typeof t&&(t=[[null,t,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<t.length;c++){var h=[].concat(t[c]);i&&s[h[0]]||(void 0!==r&&(void 0===h[5]||(h[1]="@layer".concat(h[5].length>0?" ".concat(h[5]):""," {").concat(h[1],"}")),h[5]=r),n&&(h[2]?(h[1]="@media ".concat(h[2]," {").concat(h[1],"}"),h[2]=n):h[2]=n),o&&(h[4]?(h[1]="@supports (".concat(h[4],") {").concat(h[1],"}"),h[4]=o):h[4]="".concat(o)),e.push(h))}},e}},1354:t=>{"use strict";t.exports=function(t){var e=t[1],n=t[3];if(!n)return e;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),o="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),r="/*# ".concat(o," */");return[e].concat([r]).join("\n")}return[e].join("\n")}},2017:t=>{"use strict";t.exports=function t(e,n){if(e===n)return!0;if(e&&n&&"object"==typeof e&&"object"==typeof n){if(e.constructor!==n.constructor)return!1;var i,o,r;if(Array.isArray(e)){if((i=e.length)!=n.length)return!1;for(o=i;0!=o--;)if(!t(e[o],n[o]))return!1;return!0}if(e.constructor===RegExp)return e.source===n.source&&e.flags===n.flags;if(e.valueOf!==Object.prototype.valueOf)return e.valueOf()===n.valueOf();if(e.toString!==Object.prototype.toString)return e.toString()===n.toString();if((i=(r=Object.keys(e)).length)!==Object.keys(n).length)return!1;for(o=i;0!=o--;)if(!Object.prototype.hasOwnProperty.call(n,r[o]))return!1;for(o=i;0!=o--;){var s=r[o];if(!t(e[s],n[s]))return!1}return!0}return e!=e&&n!=n}},9982:function(t,e,n){var i;!function(){var e={};!function(t){"use strict";t.__esModule=!0,t.digestLength=32,t.blockSize=64;var e=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(t,n,i,o,r){for(var s,a,l,c,h,u,d,p,m,f,g,y,b;r>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],h=n[4],u=n[5],d=n[6],p=n[7],f=0;f<16;f++)g=o+4*f,t[f]=(255&i[g])<<24|(255&i[g+1])<<16|(255&i[g+2])<<8|255&i[g+3];for(f=16;f<64;f++)y=((m=t[f-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,b=((m=t[f-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,t[f]=(y+t[f-7]|0)+(b+t[f-16]|0);for(f=0;f<64;f++)y=(((h>>>6|h<<26)^(h>>>11|h<<21)^(h>>>25|h<<7))+(h&u^~h&d)|0)+(p+(e[f]+t[f]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,p=d,d=u,u=h,h=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=h,n[5]+=u,n[6]+=d,n[7]+=p,o+=64,r-=64}return o}var i=function(){function e(){this.digestLength=t.digestLength,this.blockSize=t.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return e.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},e.prototype.clean=function(){for(var t=0;t<this.buffer.length;t++)this.buffer[t]=0;for(t=0;t<this.temp.length;t++)this.temp[t]=0;this.reset()},e.prototype.update=function(t,e){if(void 0===e&&(e=t.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=e,this.bufferLength>0){for(;this.bufferLength<64&&e>0;)this.buffer[this.bufferLength++]=t[i++],e--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(e>=64&&(i=n(this.temp,this.state,t,i,e),e%=64);e>0;)this.buffer[this.bufferLength++]=t[i++],e--;return this},e.prototype.finish=function(t){if(!this.finished){var e=this.bytesHashed,i=this.bufferLength,o=e/536870912|0,r=e<<3,s=e%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=o>>>24&255,this.buffer[s-7]=o>>>16&255,this.buffer[s-6]=o>>>8&255,this.buffer[s-5]=o>>>0&255,this.buffer[s-4]=r>>>24&255,this.buffer[s-3]=r>>>16&255,this.buffer[s-2]=r>>>8&255,this.buffer[s-1]=r>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)t[4*a+0]=this.state[a]>>>24&255,t[4*a+1]=this.state[a]>>>16&255,t[4*a+2]=this.state[a]>>>8&255,t[4*a+3]=this.state[a]>>>0&255;return this},e.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},e.prototype._saveState=function(t){for(var e=0;e<this.state.length;e++)t[e]=this.state[e]},e.prototype._restoreState=function(t,e){for(var n=0;n<this.state.length;n++)this.state[n]=t[n];this.bytesHashed=e,this.finished=!1,this.bufferLength=0},e}();t.Hash=i;var o=function(){function t(t){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var e=new Uint8Array(this.blockSize);if(t.length>this.blockSize)(new i).update(t).finish(e).clean();else for(var n=0;n<t.length;n++)e[n]=t[n];for(n=0;n<e.length;n++)e[n]^=54;for(this.inner.update(e),n=0;n<e.length;n++)e[n]^=106;for(this.outer.update(e),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<e.length;n++)e[n]=0}return t.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},t.prototype.clean=function(){for(var t=0;t<this.istate.length;t++)this.ostate[t]=this.istate[t]=0;this.inner.clean(),this.outer.clean()},t.prototype.update=function(t){return this.inner.update(t),this},t.prototype.finish=function(t){return this.outer.finished?this.outer.finish(t):(this.inner.finish(t),this.outer.update(t,this.digestLength).finish(t)),this},t.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},t}();function r(t){var e=(new i).update(t),n=e.digest();return e.clean(),n}function s(t,e){var n=new o(t).update(e),i=n.digest();return n.clean(),i}function a(t,e,n,i){var o=i[0];if(0===o)throw new Error("hkdf: cannot expand more");e.reset(),o>1&&e.update(t),n&&e.update(n),e.update(i),e.finish(t),i[0]++}t.HMAC=o,t.hash=r,t.default=r,t.hmac=s;var l=new Uint8Array(t.digestLength);t.hkdf=function(t,e,n,i){void 0===e&&(e=l),void 0===i&&(i=32);for(var r=new Uint8Array([1]),c=s(e,t),h=new o(c),u=new Uint8Array(h.digestLength),d=u.length,p=new Uint8Array(i),m=0;m<i;m++)d===u.length&&(a(u,h,n,r),d=0),p[m]=u[d++];return h.clean(),u.fill(0),r.fill(0),p},t.pbkdf2=function(t,e,n,i){for(var r=new o(t),s=r.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),h=new Uint8Array(i),u=0;u*s<i;u++){var d=u+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,r.reset(),r.update(e),r.update(a),r.finish(c);for(var p=0;p<s;p++)l[p]=c[p];for(p=2;p<=n;p++){r.reset(),r.update(c).finish(c);for(var m=0;m<s;m++)l[m]^=c[m]}for(p=0;p<s&&u*s+p<i;p++)h[u*s+p]=l[p]}for(u=0;u<s;u++)l[u]=c[u]=0;for(u=0;u<4;u++)a[u]=0;return r.clean(),h}}(e);var o=e.default;for(var r in e)o[r]=e[r];"object"==typeof t.exports?t.exports=o:void 0===(i=function(){return o}.call(e,n,e,t))||(t.exports=i)}()},2787:(t,e,n)=>{"use strict";n.d(e,{I:()=>o});const i=new Uint32Array(65536),o=(t,e)=>{if(t.length<e.length){const n=e;e=t,t=n}return 0===e.length?t.length:t.length<=32?((t,e)=>{const n=t.length,o=e.length,r=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[t.charCodeAt(c)]|=1<<c;for(c=0;c<o;c++){let t=i[e.charCodeAt(c)];const n=t|a;t|=(t&s)+s^s,a|=~(t|s),s&=t,a&r&&l++,s&r&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[t.charCodeAt(c)]=0;return l})(t,e):((t,e)=>{const n=e.length,o=t.length,r=[],s=[],a=Math.ceil(n/32),l=Math.ceil(o/32);for(let t=0;t<a;t++)s[t]=-1,r[t]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const h=32*c,u=Math.min(32,o)+h;for(let e=h;e<u;e++)i[t.charCodeAt(e)]|=1<<e;for(let t=0;t<n;t++){const n=i[e.charCodeAt(t)],o=s[t/32|0]>>>t&1,c=r[t/32|0]>>>t&1,h=n|a,u=((n|c)&l)+l^l|n|c;let d=a|~(u|l),p=l&u;d>>>31^o&&(s[t/32|0]^=1<<t),p>>>31^c&&(r[t/32|0]^=1<<t),d=d<<1|o,p=p<<1|c,l=p|~(h|d),a=d&h}for(let e=h;e<u;e++)i[t.charCodeAt(e)]=0}let h=0,u=-1;const d=32*c,p=Math.min(32,o-d)+d;for(let e=d;e<p;e++)i[t.charCodeAt(e)]|=1<<e;let m=o;for(let t=0;t<n;t++){const n=i[e.charCodeAt(t)],a=s[t/32|0]>>>t&1,l=r[t/32|0]>>>t&1,c=n|h,d=((n|l)&u)+u^u|n|l;let p=h|~(d|u),f=u&d;m+=p>>>o-1&1,m-=f>>>o-1&1,p>>>31^a&&(s[t/32|0]^=1<<t),f>>>31^l&&(r[t/32|0]^=1<<t),p=p<<1|a,f=f<<1|l,u=f|~(c|p),h=p&c}for(let e=d;e<p;e++)i[t.charCodeAt(e)]=0;return m})(t,e)}},9937:t=>{t.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(t,e)=>{e.assign=function(t){t=t||{};var e,n,i,o=Array.prototype.slice.call(arguments).slice(1);for(e=0,i=o.length;e<i;e++)if(o[e])for(n in o[e])t[n]=o[e][n];return t},e.validateSettings=function(t){return"linLogMode"in t&&"boolean"!=typeof t.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in t&&"boolean"!=typeof t.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in t&&"boolean"!=typeof t.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in t&&"number"!=typeof t.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in t)||"number"==typeof t.scalingRatio&&t.scalingRatio>=0?"strongGravityMode"in t&&"boolean"!=typeof t.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in t)||"number"==typeof t.gravity&&t.gravity>=0?"slowDown"in t&&!("number"==typeof t.slowDown||t.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in t&&"boolean"!=typeof t.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in t)||"number"==typeof t.barnesHutTheta&&t.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},e.graphToByteArrays=function(t,e){var n,i=t.order,o=t.size,r={},s=new Float32Array(10*i),a=new Float32Array(3*o);return n=0,t.forEachNode((function(t,e){r[t]=n,s[n]=e.x,s[n+1]=e.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=e.size||1,s[n+9]=e.fixed?1:0,n+=10})),n=0,t.forEachEdge((function(t,i,o,l,c,h,u){var d=r[o],p=r[l],m=e(t,i,o,l,c,h,u);s[d+6]+=m,s[p+6]+=m,a[n]=d,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:s,edges:a}},e.assignLayoutChanges=function(t,e,n){var i=0;t.updateEachNodeAttributes((function(t,o){return o.x=e[i],o.y=e[i+1],i+=10,n?n(t,o):o}))},e.readGraphPositions=function(t,e){var n=0;t.forEachNode((function(t,i){e[n]=i.x,e[n+1]=i.y,n+=10}))},e.collectLayoutChanges=function(t,e,n){for(var i=t.nodes(),o={},r=0,s=0,a=e.length;r<a;r+=10){if(n){var l=Object.assign({},t.getNodeAttributes(i[s]));l.x=e[r],l.y=e[r+1],l=n(i[s],l),o[i[s]]={x:l.x,y:l.y}}else o[i[s]]={x:e[r],y:e[r+1]};s++}return o},e.createWorker=function(t){var e=window.URL||window.webkitURL,n=t.toString(),i=e.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),o=new Worker(i);return e.revokeObjectURL(i),o}},8903:(t,e,n)=>{var i=n(1736),o=n(8153).Fd,r=n(2561),s=n(1782),a=n(9937);function l(t,e,n){if(!i(e))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=o("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,h="function"==typeof n.outputReducer?n.outputReducer:null,u=s.assign({},a,n.settings),d=s.validateSettings(u);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var p,m=s.graphToByteArrays(e,c);for(p=0;p<l;p++)r(u,m.nodes,m.edges);if(!t)return s.collectLayoutChanges(e,m.nodes);s.assignLayoutChanges(e,m.nodes,h)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(t){var e="number"==typeof t?t:t.order;return{barnesHutOptimize:e>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(e)}},t.exports=c},2561:t=>{var e=10;t.exports=function(t,n,i){var o,r,s,a,l,c,h,u,d,p,m,f,g,y,b,v,w,C,A,S,x,E,T,M=n.length,_=i.length,I=t.adjustSizes,L=t.barnesHutTheta*t.barnesHutTheta,N=[];for(s=0;s<M;s+=e)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(t.outboundAttractionDistribution){for(m=0,s=0;s<M;s+=e)m+=n[s+6];m/=M/e}if(t.barnesHutOptimize){var P,$,R,k=1/0,O=-1/0,H=1/0,G=-1/0;for(s=0;s<M;s+=e)k=Math.min(k,n[s+0]),O=Math.max(O,n[s+0]),H=Math.min(H,n[s+1]),G=Math.max(G,n[s+1]);var F=O-k,D=G-H;for(F>D?G=(H-=(F-D)/2)+F:O=(k-=(D-F)/2)+D,N[0]=-1,N[1]=(k+O)/2,N[2]=(H+G)/2,N[3]=Math.max(O-k,G-H),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,o=1,s=0;s<M;s+=e)for(r=0,R=3;;){if(!(N[r+5]>=0)){if(N[r+0]<0){N[r+0]=s;break}if(N[r+5]=9*o,u=N[r+3]/2,N[(d=N[r+5])+0]=-1,N[d+1]=N[r+1]-u,N[d+2]=N[r+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]-u,N[d+2]=N[r+2]+u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+u,N[d+2]=N[r+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+u,N[d+2]=N[r+2]+u,N[d+3]=u,N[d+4]=N[r+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,o+=4,P=n[N[r+0]+0]<N[r+1]?n[N[r+0]+1]<N[r+2]?N[r+5]:N[r+5]+9:n[N[r+0]+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+6]=n[N[r+0]+6],N[r+7]=n[N[r+0]+0],N[r+8]=n[N[r+0]+1],N[P+0]=N[r+0],N[r+0]=-1,P===($=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27)){if(R--){r=P;continue}R=3;break}N[$+0]=s;break}P=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+7]=(N[r+7]*N[r+6]+n[s+0]*n[s+6])/(N[r+6]+n[s+6]),N[r+8]=(N[r+8]*N[r+6]+n[s+1]*n[s+6])/(N[r+6]+n[s+6]),N[r+6]+=n[s+6],r=P}}if(t.barnesHutOptimize){for(f=t.scalingRatio,s=0;s<M;s+=e)for(r=0;;)if(N[r+5]>=0){if(v=Math.pow(n[s+0]-N[r+7],2)+Math.pow(n[s+1]-N[r+8],2),4*(p=N[r+3])*p/v<L){if(g=n[s+0]-N[r+7],y=n[s+1]-N[r+8],!0===I?v>0?(w=f*n[s+6]*N[r+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*N[r+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*N[r+6]/v,n[s+2]+=g*w,n[s+3]+=y*w),(r=N[r+4])<0)break;continue}r=N[r+5]}else if((c=N[r+0])>=0&&c!==s&&(v=(g=n[s+0]-n[c+0])*g+(y=n[s+1]-n[c+1])*y,!0===I?v>0?(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w)),(r=N[r+4])<0)break}else for(f=t.scalingRatio,a=0;a<M;a+=e)for(l=0;l<a;l+=e)g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8])>0?(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):v<0&&(w=100*f*n[a+6]*n[l+6],n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):(v=Math.sqrt(g*g+y*y))>0&&(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);for(d=t.gravity/t.scalingRatio,f=t.scalingRatio,s=0;s<M;s+=e)w=0,g=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),t.strongGravityMode?v>0&&(w=f*n[s+6]*d):v>0&&(w=f*n[s+6]*d/v),n[s+2]-=g*w,n[s+3]-=y*w;for(f=1*(t.outboundAttractionDistribution?m:1),h=0;h<_;h+=3)a=i[h+0],l=i[h+1],u=i[h+2],b=Math.pow(u,t.edgeWeightInfluence),g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8],t.linLogMode?t.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):t.outboundAttractionDistribution?v>0&&(w=-f*b/n[a+6]):v>0&&(w=-f*b)):(v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),t.linLogMode?t.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):t.outboundAttractionDistribution?(v=1,w=-f*b/n[a+6]):(v=1,w=-f*b)),v>0&&(n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);if(!0===I)for(s=0;s<M;s+=e)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+S)/(1+Math.sqrt(A)),E=n[s+0]+n[s+2]*(x/t.slowDown),n[s+0]=E,T=n[s+1]+n[s+3]*(x/t.slowDown),n[s+1]=T);else for(s=0;s<M;s+=e)1!==n[s+9]&&(A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+S)/(1+Math.sqrt(A)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(A)))),E=n[s+0]+n[s+2]*(x/t.slowDown),n[s+0]=E,T=n[s+1]+n[s+3]*(x/t.slowDown),n[s+1]=T);return{}}},8153:(t,e)=>{function n(t){return"number"!=typeof t||isNaN(t)?1:t}e.Fd=function(t){return function(t,e){var n={},i=function(t){return void 0===t?e:t};"function"==typeof e&&(i=e);var o=function(e){return i(e[t])},r=function(){return i(void 0)};return"string"==typeof t?(n.fromAttributes=o,n.fromGraph=function(t,e){return o(t.getEdgeAttributes(e))},n.fromEntry=function(t,e){return o(e)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof t?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(e,n){var o=e.extremities(n);return i(t(n,e.getEdgeAttributes(n),o[0],o[1],e.getNodeAttributes(o[0]),e.getNodeAttributes(o[1]),e.isUndirected(n)))},n.fromEntry=function(e,n,o,r,s,a,l){return i(t(e,n,o,r,s,a,l))},n.fromPartialEntry=function(e,n,o,r){return i(t(e,n,o,r))},n.fromMinimalEntry=function(e,n){return i(t(e,n))}):(n.fromAttributes=r,n.fromGraph=r,n.fromEntry=r,n.fromMinimalEntry=r),n}(t,n)}},1736:t=>{t.exports=function(t){return null!==t&&"object"==typeof t&&"function"==typeof t.addUndirectedEdgeWithKey&&"function"==typeof t.dropNode&&"boolean"==typeof t.multi}},934:function(t){t.exports=function(){"use strict";function t(e){return(t="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(e)}function e(t,e){t.prototype=Object.create(e.prototype),t.prototype.constructor=t,i(t,e)}function n(t){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(t){return t.__proto__||Object.getPrototypeOf(t)},n(t)}function i(t,e){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(t,e){return t.__proto__=e,t},i(t,e)}function o(t,e,n){return o=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(t){return!1}}()?Reflect.construct.bind():function(t,e,n){var o=[null];o.push.apply(o,e);var r=new(Function.bind.apply(t,o));return n&&i(r,n.prototype),r},o.apply(null,arguments)}function r(t){var e="function"==typeof Map?new Map:void 0;return r=function(t){if(null===t||(r=t,-1===Function.toString.call(r).indexOf("[native code]")))return t;var r;if("function"!=typeof t)throw new TypeError("Super expression must either be null or a function");if(void 0!==e){if(e.has(t))return e.get(t);e.set(t,s)}function s(){return o(t,arguments,n(this).constructor)}return s.prototype=Object.create(t.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,t)},r(t)}function s(t){if(void 0===t)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return t}var a=function(){for(var t=arguments[0],e=1,n=arguments.length;e<n;e++)if(arguments[e])for(var i in arguments[e])t[i]=arguments[e][i];return t};function l(t,e,n,i){var o=t._nodes.get(e),r=null;return o?r="mixed"===i?o.out&&o.out[n]||o.undirected&&o.undirected[n]:"directed"===i?o.out&&o.out[n]:o.undirected&&o.undirected[n]:r}function c(e){return"object"===t(e)&&null!==e}function h(t){var e;for(e in t)return!1;return!0}function u(t,e,n){Object.defineProperty(t,e,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(t,e,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(t,e,i)}function p(t){return!(!c(t)||t.attributes&&!Array.isArray(t.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,f={exports:{}},g="object"==typeof Reflect?Reflect:null,y=g&&"function"==typeof g.apply?g.apply:function(t,e,n){return Function.prototype.apply.call(t,e,n)};m=g&&"function"==typeof g.ownKeys?g.ownKeys:Object.getOwnPropertySymbols?function(t){return Object.getOwnPropertyNames(t).concat(Object.getOwnPropertySymbols(t))}:function(t){return Object.getOwnPropertyNames(t)};var b=Number.isNaN||function(t){return t!=t};function v(){v.init.call(this)}f.exports=v,f.exports.once=function(t,e){return new Promise((function(n,i){function o(n){t.removeListener(e,r),i(n)}function r(){"function"==typeof t.removeListener&&t.removeListener("error",o),n([].slice.call(arguments))}I(t,e,r,{once:!0}),"error"!==e&&function(t,e){"function"==typeof t.on&&I(t,"error",e,{once:!0})}(t,o)}))},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(t){if("function"!=typeof t)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof t)}function A(t){return void 0===t._maxListeners?v.defaultMaxListeners:t._maxListeners}function S(t,e,n,i){var o,r,s,a;if(C(n),void 0===(r=t._events)?(r=t._events=Object.create(null),t._eventsCount=0):(void 0!==r.newListener&&(t.emit("newListener",e,n.listener?n.listener:n),r=t._events),s=r[e]),void 0===s)s=r[e]=n,++t._eventsCount;else if("function"==typeof s?s=r[e]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(o=A(t))>0&&s.length>o&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(e)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=t,l.type=e,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return t}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function E(t,e,n){var i={fired:!1,wrapFn:void 0,target:t,type:e,listener:n},o=x.bind(i);return o.listener=n,i.wrapFn=o,o}function T(t,e,n){var i=t._events;if(void 0===i)return[];var o=i[e];return void 0===o?[]:"function"==typeof o?n?[o.listener||o]:[o]:n?function(t){for(var e=new Array(t.length),n=0;n<e.length;++n)e[n]=t[n].listener||t[n];return e}(o):_(o,o.length)}function M(t){var e=this._events;if(void 0!==e){var n=e[t];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function _(t,e){for(var n=new Array(e),i=0;i<e;++i)n[i]=t[i];return n}function I(t,e,n,i){if("function"==typeof t.on)i.once?t.once(e,n):t.on(e,n);else{if("function"!=typeof t.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof t);t.addEventListener(e,(function o(r){i.once&&t.removeEventListener(e,o),n(r)}))}}function L(t){if("function"!=typeof t)throw new Error("obliterator/iterator: expecting a function!");this.next=t}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(t){if("number"!=typeof t||t<0||b(t))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+t+".");w=t}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(t){if("number"!=typeof t||t<0||b(t))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+t+".");return this._maxListeners=t,this},v.prototype.getMaxListeners=function(){return A(this)},v.prototype.emit=function(t){for(var e=[],n=1;n<arguments.length;n++)e.push(arguments[n]);var i="error"===t,o=this._events;if(void 0!==o)i=i&&void 0===o.error;else if(!i)return!1;if(i){var r;if(e.length>0&&(r=e[0]),r instanceof Error)throw r;var s=new Error("Unhandled error."+(r?" ("+r.message+")":""));throw s.context=r,s}var a=o[t];if(void 0===a)return!1;if("function"==typeof a)y(a,this,e);else{var l=a.length,c=_(a,l);for(n=0;n<l;++n)y(c[n],this,e)}return!0},v.prototype.addListener=function(t,e){return S(this,t,e,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(t,e){return S(this,t,e,!0)},v.prototype.once=function(t,e){return C(e),this.on(t,E(this,t,e)),this},v.prototype.prependOnceListener=function(t,e){return C(e),this.prependListener(t,E(this,t,e)),this},v.prototype.removeListener=function(t,e){var n,i,o,r,s;if(C(e),void 0===(i=this._events))return this;if(void 0===(n=i[t]))return this;if(n===e||n.listener===e)0==--this._eventsCount?this._events=Object.create(null):(delete i[t],i.removeListener&&this.emit("removeListener",t,n.listener||e));else if("function"!=typeof n){for(o=-1,r=n.length-1;r>=0;r--)if(n[r]===e||n[r].listener===e){s=n[r].listener,o=r;break}if(o<0)return this;0===o?n.shift():function(t,e){for(;e+1<t.length;e++)t[e]=t[e+1];t.pop()}(n,o),1===n.length&&(i[t]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",t,s||e)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(t){var e,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[t]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[t]),this;if(0===arguments.length){var o,r=Object.keys(n);for(i=0;i<r.length;++i)"removeListener"!==(o=r[i])&&this.removeAllListeners(o);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(e=n[t]))this.removeListener(t,e);else if(void 0!==e)for(i=e.length-1;i>=0;i--)this.removeListener(t,e[i]);return this},v.prototype.listeners=function(t){return T(this,t,!0)},v.prototype.rawListeners=function(t){return T(this,t,!1)},v.listenerCount=function(t,e){return"function"==typeof t.listenerCount?t.listenerCount(e):M.call(t,e)},v.prototype.listenerCount=M,v.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&(L.prototype[Symbol.iterator]=function(){return this}),L.of=function(){var t=arguments,e=t.length,n=0;return new L((function(){return n>=e?{done:!0}:{done:!1,value:t[n++]}}))},L.empty=function(){return new L((function(){return{done:!0}}))},L.fromSequence=function(t){var e=0,n=t.length;return new L((function(){return e>=n?{done:!0}:{done:!1,value:t[e++]}}))},L.is=function(t){return t instanceof L||"object"==typeof t&&null!==t&&"function"==typeof t.next};var N=L,P={};P.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,P.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var $=N,R=P,k=R.ARRAY_BUFFER_SUPPORT,O=R.SYMBOL_SUPPORT,H=function(t){var e=function(t){return"string"==typeof t||Array.isArray(t)||k&&ArrayBuffer.isView(t)?$.fromSequence(t):"object"!=typeof t||null===t?null:O&&"function"==typeof t[Symbol.iterator]?t[Symbol.iterator]():"function"==typeof t.next?t:null}(t);if(!e)throw new Error("obliterator: target is not iterable nor a valid iterator.");return e},G=H,F=function(t,e){for(var n,i=arguments.length>1?e:1/0,o=i!==1/0?new Array(i):[],r=0,s=G(t);;){if(r===i)return o;if((n=s.next()).done)return r!==e&&(o.length=r),o;o[r++]=n.value}},D=function(t){function n(e){var n;return(n=t.call(this)||this).name="GraphError",n.message=e,n}return e(n,t),n}(r(Error)),B=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(D),V=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(D),W=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(D);function U(t,e){this.key=t,this.attributes=e,this.clear()}function j(t,e){this.key=t,this.attributes=e,this.clear()}function q(t,e){this.key=t,this.attributes=e,this.clear()}function z(t,e,n,i,o){this.key=e,this.attributes=o,this.undirected=t,this.source=n,this.target=i}function Y(t,e,n,i,o,r,s){var a,l,c,h;if(i=""+i,0===n){if(!(a=t._nodes.get(i)))throw new V("Graph.".concat(e,': could not find the "').concat(i,'" node in the graph.'));c=o,h=r}else if(3===n){if(o=""+o,!(l=t._edges.get(o)))throw new V("Graph.".concat(e,': could not find the "').concat(o,'" edge in the graph.'));var u=l.source.key,d=l.target.key;if(i===u)a=l.target;else{if(i!==d)throw new V("Graph.".concat(e,': the "').concat(i,'" node is not attached to the "').concat(o,'" edge (').concat(u,", ").concat(d,")."));a=l.source}c=r,h=s}else{if(!(l=t._edges.get(i)))throw new V("Graph.".concat(e,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=o,h=r}return[a,c,h]}U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},j.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},q.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},z.prototype.attach=function(){var t="out",e="in";this.undirected&&(t=e="undirected");var n=this.source.key,i=this.target.key;this.source[t][i]=this,this.undirected&&n===i||(this.target[e][n]=this)},z.prototype.attachMulti=function(){var t="out",e="in",n=this.source.key,i=this.target.key;this.undirected&&(t=e="undirected");var o=this.source[t],r=o[i];if(void 0===r)return o[i]=this,void(this.undirected&&n===i||(this.target[e][n]=this));r.previous=this,this.next=r,o[i]=this,this.target[e][n]=this},z.prototype.detach=function(){var t=this.source.key,e=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][e],delete this.target[i][t]},z.prototype.detachMulti=function(){var t=this.source.key,e=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][e],delete this.target[i][t]):(this.next.previous=void 0,this.source[n][e]=this.next,this.target[i][t]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(t){return"get".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r=Y(this,e,n,t,i,o),s=r[0],a=r[1];return s.attributes[a]}}},{name:function(t){return"get".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){return Y(this,e,n,t,i)[0].attributes}}},{name:function(t){return"has".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r=Y(this,e,n,t,i,o),s=r[0],a=r[1];return s.attributes.hasOwnProperty(a)}}},{name:function(t){return"set".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o,r){var s=Y(this,e,n,t,i,o,r),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(t){return"update".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o,r){var s=Y(this,e,n,t,i,o,r),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new B("Graph.".concat(e,": updater should be a function."));var h=a.attributes,u=c(h[l]);return h[l]=u,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(t){return"remove".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r=Y(this,e,n,t,i,o),s=r[0],a=r[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(t){return"replace".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r=Y(this,e,n,t,i,o),s=r[0],a=r[1];if(!c(a))throw new B("Graph.".concat(e,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(t){return"merge".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r=Y(this,e,n,t,i,o),s=r[0],l=r[1];if(!c(l))throw new B("Graph.".concat(e,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(t){return"update".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r=Y(this,e,n,t,i,o),s=r[0],a=r[1];if("function"!=typeof a)throw new B("Graph.".concat(e,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(t){return"get".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return o.attributes[i]}}},{name:function(t){return"get".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,r=""+arguments[1];if(!(i=l(this,o,r,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(r,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(i=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return i.attributes}}},{name:function(t){return"has".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return o.attributes.hasOwnProperty(i)}}},{name:function(t){return"set".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+t,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return r.attributes[i]=o,this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(t){return"update".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+t,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if("function"!=typeof o)throw new B("Graph.".concat(e,": updater should be a function."));return r.attributes[i]=o(r.attributes[i]),this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(t){return"remove".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return delete o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(t){return"replace".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if(!c(i))throw new B("Graph.".concat(e,": provided attributes are not a plain object."));return o.attributes=i,this.emit("edgeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(t){return"merge".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if(!c(i))throw new B("Graph.".concat(e,": provided attributes are not a plain object."));return a(o.attributes,i),this.emit("edgeAttributesUpdated",{key:o.key,type:"merge",attributes:o.attributes,data:i}),this}}},{name:function(t){return"update".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if("function"!=typeof i)throw new B("Graph.".concat(e,": provided updater is not a function."));return o.attributes=i(o.attributes),this.emit("edgeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],X=N,J=H,Q=function(){var t=arguments,e=null,n=-1;return new X((function(){for(var i=null;;){if(null===e){if(++n>=t.length)return{done:!0};e=J(t[n])}if(!0!==(i=e.next()).done)break;e=null}return i}))},tt=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function et(t,e,n,i){var o=!1;for(var r in e)if(r!==i){var s=e[r];if(o=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),t&&o)return s.key}}function nt(t,e,n,i){var o,r,s,a=!1;for(var l in e)if(l!==i){o=e[l];do{if(r=o.source,s=o.target,a=n(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected),t&&a)return o.key;o=o.next}while(void 0!==o)}}function it(t,e){var n,i=Object.keys(t),o=i.length,r=0;return new N((function(){do{if(n)n=n.next;else{if(r>=o)return{done:!0};var s=i[r++];if(s===e){n=void 0;continue}n=t[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function ot(t,e,n,i){var o=e[n];if(o){var r=o.source,s=o.target;return i(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected)&&t?o.key:void 0}}function rt(t,e,n,i){var o=e[n];if(o){var r=!1;do{if(r=i(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),t&&r)return o.key;o=o.next}while(void 0!==o)}}function st(t,e){var n=t[e];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var t={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:t}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function at(t,e,n,i){if(0!==e.size)for(var o,r,s="mixed"!==n&&n!==e.type,a="undirected"===n,l=!1,c=e._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var h=r,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,r.undirected),t&&l)return u}}function lt(t,e,n,i,o,r){var s,a=e?nt:et;if("undirected"!==n){if("out"!==i&&(s=a(t,o.in,r),t&&s))return s;if("in"!==i&&(s=a(t,o.out,r,i?void 0:o.key),t&&s))return s}if("directed"!==n&&(s=a(t,o.undirected,r),t&&s))return s}function ct(t,e,n,i,o,r,s){var a,l=n?rt:ot;if("undirected"!==e){if(void 0!==o.in&&"out"!==i&&(a=l(t,o.in,r,s),t&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(t,o.out,r,s),t&&a))return a}if("directed"!==e&&void 0!==o.undirected&&(a=l(t,o.undirected,r,s),t&&a))return a}var ht=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ut(){this.A=null,this.B=null}function dt(t,e,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!e||!e.has(c.key)){var h=o(c.key,c.attributes);if(t&&h)return c.key}}}function pt(t,e,n,i,o){if("mixed"!==e){if("undirected"===e)return dt(t,null,i,i.undirected,o);if("string"==typeof n)return dt(t,null,i,i[n],o)}var r,s=new ut;if("undirected"!==e){if("out"!==n){if(r=dt(t,null,i,i.in,o),t&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=dt(t,s,i,i.out,o),t&&r)return r;s.wrap(i.out)}}if("directed"!==e&&(r=dt(t,s,i,i.undirected,o),t&&r))return r}function mt(t,e,n){var i=Object.keys(n),o=i.length,r=0;return new N((function(){var s=null;do{if(r>=o)return t&&t.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===e?c:l,t&&t.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function ft(t,e,n,i,o){for(var r,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(e&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=o(s.key,null,s.attributes,null,null,null,null),t&&u))return null}}function gt(t){if(!c(t))throw new B('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in t))throw new B("Graph.import: serialized node is missing its key.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new B("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function yt(t){if(!c(t))throw new B('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in t))throw new B("Graph.import: serialized edge is missing its source.");if(!("target"in t))throw new B("Graph.import: serialized edge is missing its target.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new B("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in t&&"boolean"!=typeof t.undirected)throw new B("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ut.prototype.wrap=function(t){null===this.A?this.A=t:null===this.B&&(this.B=t)},ut.prototype.has=function(t){return null!==this.A&&t in this.A||null!==this.B&&t in this.B};var bt,vt=(bt=255&Math.floor(256*Math.random()),function(){return bt++}),wt=new Set(["directed","undirected","mixed"]),Ct=new Set(["domain","_events","_eventsCount","_maxListeners"]),At={allowSelfLoops:!0,multi:!1,type:"mixed"};function St(t,e,n){var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}function xt(t,e,n,i,o,r,s,a){if(!i&&"undirected"===t.type)throw new W("Graph.".concat(e,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new W("Graph.".concat(e,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new B("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!t.allowSelfLoops&&r===s)throw new W("Graph.".concat(e,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=t._nodes.get(r),h=t._nodes.get(s);if(!l)throw new V("Graph.".concat(e,': source node "').concat(r,'" not found.'));if(!h)throw new V("Graph.".concat(e,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=t._edgeKeyGenerator();else if(o=""+o,t._edges.has(o))throw new W("Graph.".concat(e,': the "').concat(o,'" edge already exists in the graph.'));if(!t.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new W("Graph.".concat(e,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,h,a);t._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,t._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,u.key=o,t.emit("edgeAdded",u),o}function Et(t,e,n,i,o,r,s,l,h){if(!i&&"undirected"===t.type)throw new W("Graph.".concat(e,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new W("Graph.".concat(e,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new B("Graph.".concat(e,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new B("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(r=""+r,s=""+s,h&&(u=l,l=void 0),!t.allowSelfLoops&&r===s)throw new W("Graph.".concat(e,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=t._nodes.get(r),f=t._nodes.get(s);if(!n&&(d=t._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new W("Graph.".concat(e,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||t.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(h?!u:!l)return g;if(h){var y=p.attributes;p.attributes=u(y),t.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),t.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=t._edgeKeyGenerator();else if(o=""+o,t._edges.has(o))throw new W("Graph.".concat(e,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=St(t,r,{}),v=!0,r===s&&(f=m,w=!0)),f||(f=St(t,s,{}),w=!0),d=new z(i,o,m,f,l),t._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,t._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,b.key=o,t.emit("edgeAdded",b),[o,!0,v,w]}function Tt(t,e){t._edges.delete(e.key);var n=e.source,i=e.target,o=e.attributes,r=e.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,t._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,t._directedSelfLoopCount--)),t.multi?e.detachMulti():e.detach(),r?t._undirectedSize--:t._directedSize--,t.emit("edgeDropped",{key:e.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Mt=function(n){function i(t){var e;if(e=n.call(this)||this,"boolean"!=typeof(t=a({},At,t)).multi)throw new B("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(t.multi,'".'));if(!wt.has(t.type))throw new B('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(t.type,'".'));if("boolean"!=typeof t.allowSelfLoops)throw new B("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(t.allowSelfLoops,'".'));var i="mixed"===t.type?U:"directed"===t.type?j:q;u(s(e),"NodeDataClass",i);var o="geid_"+vt()+"_",r=0;return u(s(e),"_attributes",{}),u(s(e),"_nodes",new Map),u(s(e),"_edges",new Map),u(s(e),"_directedSize",0),u(s(e),"_undirectedSize",0),u(s(e),"_directedSelfLoopCount",0),u(s(e),"_undirectedSelfLoopCount",0),u(s(e),"_edgeKeyGenerator",(function(){var t;do{t=o+r++}while(e._edges.has(t));return t})),u(s(e),"_options",t),Ct.forEach((function(t){return u(s(e),t,e[t])})),d(s(e),"order",(function(){return e._nodes.size})),d(s(e),"size",(function(){return e._edges.size})),d(s(e),"directedSize",(function(){return e._directedSize})),d(s(e),"undirectedSize",(function(){return e._undirectedSize})),d(s(e),"selfLoopCount",(function(){return e._directedSelfLoopCount+e._undirectedSelfLoopCount})),d(s(e),"directedSelfLoopCount",(function(){return e._directedSelfLoopCount})),d(s(e),"undirectedSelfLoopCount",(function(){return e._undirectedSelfLoopCount})),d(s(e),"multi",e._options.multi),d(s(e),"type",e._options.type),d(s(e),"allowSelfLoops",e._options.allowSelfLoops),d(s(e),"implementation",(function(){return"graphology"})),e}e(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(t){return this._nodes.has(""+t)},o.hasDirectedEdge=function(t,e){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){t=""+t,e=""+e;var o=this._nodes.get(t);return!!o&&o.out.hasOwnProperty(e)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(t,e){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){t=""+t,e=""+e;var o=this._nodes.get(t);return!!o&&o.undirected.hasOwnProperty(e)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(t,e){if(1===arguments.length){var n=""+t;return this._edges.has(n)}if(2===arguments.length){t=""+t,e=""+e;var i=this._nodes.get(t);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(e)||void 0!==i.undirected&&i.undirected.hasOwnProperty(e))}throw new B("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(t,e){if("undirected"!==this.type){if(t=""+t,e=""+e,this.multi)throw new W("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.directedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(t,e){if("directed"!==this.type){if(t=""+t,e=""+e,this.multi)throw new W("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.undirected&&n.undirected[e]||void 0;return i?i.key:void 0}},o.edge=function(t,e){if(this.multi)throw new W("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.edge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.edge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||n.undirected&&n.undirected[e]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)},o.areOutNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out},o.areInNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in},o.areUndirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"directed"!==this.type&&e in n.undirected},o.areNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)||"directed"!==this.type&&e in n.undirected},o.areInboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in||"directed"!==this.type&&e in n.undirected},o.areOutboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out||"directed"!==this.type&&e in n.undirected},o.inDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree},o.outDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree},o.directedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree},o.undirectedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegree: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree},o.inboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree),n},o.outboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.outDegree),n},o.degree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree),n},o.inDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree-e.directedLoops},o.outDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree-e.directedLoops},o.directedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree-2*e.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree-2*e.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree,i+=e.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.outDegree,i+=e.directedLoops),n-i},o.degreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree,i+=2*e.directedLoops),n-i},o.source=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.source: could not find the "'.concat(t,'" edge in the graph.'));return e.source.key},o.target=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.target: could not find the "'.concat(t,'" edge in the graph.'));return e.target.key},o.extremities=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.extremities: could not find the "'.concat(t,'" edge in the graph.'));return[e.source.key,e.target.key]},o.opposite=function(t,e){t=""+t,e=""+e;var n=this._edges.get(e);if(!n)throw new V('Graph.opposite: could not find the "'.concat(e,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(t===i)return o;if(t===o)return i;throw new V('Graph.opposite: the "'.concat(t,'" node is not attached to the "').concat(e,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(t,e){t=""+t,e=""+e;var n=this._edges.get(t);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(t,'" edge in the graph.'));return n.source.key===e||n.target.key===e},o.isUndirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isUndirected: could not find the "'.concat(t,'" edge in the graph.'));return e.undirected},o.isDirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isDirected: could not find the "'.concat(t,'" edge in the graph.'));return!e.undirected},o.isSelfLoop=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isSelfLoop: could not find the "'.concat(t,'" edge in the graph.'));return e.source===e.target},o.addNode=function(t,e){var n=function(t,e,n){if(n&&!c(n))throw new B('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(e=""+e,n=n||{},t._nodes.has(e))throw new W('Graph.addNode: the "'.concat(e,'" node already exist in the graph.'));var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}(this,t,e);return n.key},o.mergeNode=function(t,e){if(e&&!c(e))throw new B('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(e,'"'));t=""+t,e=e||{};var n=this._nodes.get(t);return n?(e&&(a(n.attributes,e),this.emit("nodeAttributesUpdated",{type:"merge",key:t,attributes:n.attributes,data:e})),[t,!1]):(n=new this.NodeDataClass(t,e),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:e}),[t,!0])},o.updateNode=function(t,e){if(e&&"function"!=typeof e)throw new B('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(e,'"'));t=""+t;var n=this._nodes.get(t);if(n){if(e){var i=n.attributes;n.attributes=e(i),this.emit("nodeAttributesUpdated",{type:"replace",key:t,attributes:n.attributes})}return[t,!1]}var o=e?e({}):{};return n=new this.NodeDataClass(t,o),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:o}),[t,!0]},o.dropNode=function(t){t=""+t;var e,n=this._nodes.get(t);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(t,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){e=n.out[i];do{Tt(this,e),e=e.next}while(e)}for(var o in n.in){e=n.in[o];do{Tt(this,e),e=e.next}while(e)}}if("directed"!==this.type)for(var r in n.undirected){e=n.undirected[r];do{Tt(this,e),e=e.next}while(e)}this._nodes.delete(t),this.emit("nodeDropped",{key:t,attributes:n.attributes})},o.dropEdge=function(t){var e;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(e=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(t=""+t,!(e=this._edges.get(t)))throw new V('Graph.dropEdge: could not find the "'.concat(t,'" edge in the graph.'));return Tt(this,e),this},o.dropDirectedEdge=function(t,e){if(arguments.length<2)throw new W("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t=""+t,e=""+e,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Tt(this,n),this},o.dropUndirectedEdge=function(t,e){if(arguments.length<2)throw new W("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t,e,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Tt(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var t,e=this._nodes.values();!0!==(t=e.next()).done;)t.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(t){return this._attributes[t]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(t){return this._attributes.hasOwnProperty(t)},o.setAttribute=function(t,e){return this._attributes[t]=e,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},o.updateAttribute=function(t,e){if("function"!=typeof e)throw new B("Graph.updateAttribute: updater should be a function.");var n=this._attributes[t];return this._attributes[t]=e(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},o.removeAttribute=function(t){return delete this._attributes[t],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:t}),this},o.replaceAttributes=function(t){if(!c(t))throw new B("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=t,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(t){if(!c(t))throw new B("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,t),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:t}),this},o.updateAttributes=function(t){if("function"!=typeof t)throw new B("Graph.updateAttributes: provided updater is not a function.");return this._attributes=t(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(t,e){if("function"!=typeof t)throw new B("Graph.updateEachNodeAttributes: expecting an updater function.");if(e&&!p(e))throw new B("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=t(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:e||null})},o.updateEachEdgeAttributes=function(t,e){if("function"!=typeof t)throw new B("Graph.updateEachEdgeAttributes: expecting an updater function.");if(e&&!p(e))throw new B("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=t(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:e||null})},o.forEachAdjacencyEntry=function(t){if("function"!=typeof t)throw new B("Graph.forEachAdjacencyEntry: expecting a callback.");ft(!1,!1,!1,this,t)},o.forEachAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new B("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!1,!0,this,t)},o.forEachAssymetricAdjacencyEntry=function(t){if("function"!=typeof t)throw new B("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ft(!1,!0,!1,this,t)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new B("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!0,!0,this,t)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(t){if("function"!=typeof t)throw new B("Graph.forEachNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)},o.findNode=function(t){if("function"!=typeof t)throw new B("Graph.findNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return n.key},o.mapNodes=function(t){if("function"!=typeof t)throw new B("Graph.mapNode: expecting a callback.");for(var e,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(e=i.next()).done;)n=e.value,o[r++]=t(n.key,n.attributes);return o},o.someNode=function(t){if("function"!=typeof t)throw new B("Graph.someNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return!0;return!1},o.everyNode=function(t){if("function"!=typeof t)throw new B("Graph.everyNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(!t((n=e.value).key,n.attributes))return!1;return!0},o.filterNodes=function(t){if("function"!=typeof t)throw new B("Graph.filterNodes: expecting a callback.");for(var e,n,i=this._nodes.values(),o=[];!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(t,e){if("function"!=typeof t)throw new B("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new B("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=e,r=this._nodes.values();!0!==(n=r.next()).done;)o=t(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var t=this._nodes.values();return new N((function(){var e=t.next();if(e.done)return e;var n=e.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},o.export=function(){var t=this,e=new Array(this._nodes.size),n=0;this._nodes.forEach((function(t,i){e[n++]=function(t,e){var n={key:t};return h(e.attributes)||(n.attributes=a({},e.attributes)),n}(i,t)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(e,o){i[n++]=function(t,e,n){var i={key:e,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===t&&n.undirected&&(i.undirected=!0),i}(t.type,o,e)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:e,edges:i}},o.import=function(t){var e,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(t instanceof i)return t.forEachNode((function(t,e){l?a.mergeNode(t,e):a.addNode(t,e)})),t.forEachEdge((function(t,e,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(t,n,i,e):a.mergeDirectedEdgeWithKey(t,n,i,e):s?a.addUndirectedEdgeWithKey(t,n,i,e):a.addDirectedEdgeWithKey(t,n,i,e)})),this;if(!c(t))throw new B("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(t.attributes){if(!c(t.attributes))throw new B("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(t.attributes):this.replaceAttributes(t.attributes)}if(t.nodes){if(o=t.nodes,!Array.isArray(o))throw new B("Graph.import: invalid nodes. Expecting an array.");for(e=0,n=o.length;e<n;e++){gt(r=o[e]);var h=r,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(t.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=t.edges,!Array.isArray(o))throw new B("Graph.import: invalid edges. Expecting an array.");for(e=0,n=o.length;e<n;e++){yt(s=o[e]);var m=s,f=m.source,g=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,f,g,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},o.nullCopy=function(t){var e=new i(a({},this._options,t));return e.replaceAttributes(a({},this.getAttributes())),e},o.emptyCopy=function(t){var e=this.nullCopy(t);return this._nodes.forEach((function(t,n){var i=a({},t.attributes);t=new e.NodeDataClass(n,i),e._nodes.set(n,t)})),e},o.copy=function(t){if("string"==typeof(t=t||{}).type&&t.type!==this.type&&"mixed"!==t.type)throw new W('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(t.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof t.multi&&t.multi!==this.multi&&!0!==t.multi)throw new W("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof t.allowSelfLoops&&t.allowSelfLoops!==this.allowSelfLoops&&!0!==t.allowSelfLoops)throw new W("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var e,n,i=this.emptyCopy(t),o=this._edges.values();!0!==(e=o.next()).done;)xt(i,"copy",!1,(n=e.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},o.toJSON=function(){return this.export()},o.toString=function(){return"[object Graph]"},o.inspect=function(){var e=this,n={};this._nodes.forEach((function(t,e){n[e]=t.attributes}));var i={},o={};this._edges.forEach((function(t,n){var r,s=t.undirected?"--":"->",a="",l=t.source.key,c=t.target.key;t.undirected&&l>c&&(r=l,l=c,c=r);var h="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?e.multi&&(void 0===o[h]?o[h]=0:o[h]++,a+="".concat(o[h],". ")):a+="[".concat(n,"]: "),i[a+=h]=t.attributes}));var r={};for(var s in this)this.hasOwnProperty(s)&&!Ct.has(s)&&"function"!=typeof this[s]&&"symbol"!==t(s)&&(r[s]=this[s]);return r.attributes=this._attributes,r.nodes=n,r.edges=i,u(r,"constructor",this.constructor),r},i}(f.exports.EventEmitter);"undefined"!=typeof Symbol&&(Mt.prototype[Symbol.for("nodejs.util.inspect.custom")]=Mt.prototype.inspect),[{name:function(t){return"".concat(t,"Edge")},generateKey:!0},{name:function(t){return"".concat(t,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(t){return"".concat(t,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(t){return"".concat(t,"EdgeWithKey")}},{name:function(t){return"".concat(t,"DirectedEdgeWithKey")},type:"directed"},{name:function(t){return"".concat(t,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(t){["add","merge","update"].forEach((function(e){var n=t.name(e),i="add"===e?xt:Et;t.generateKey?Mt.prototype[n]=function(o,r,s){return i(this,n,!0,"undirected"===(t.type||this.type),null,o,r,s,"update"===e)}:Mt.prototype[n]=function(o,r,s,a){return i(this,n,!1,"undirected"===(t.type||this.type),o,r,s,a,"update"===e)}}))})),function(t){K.forEach((function(e){var n=e.name,i=e.attacher;i(t,n("Node"),0),i(t,n("Source"),1),i(t,n("Target"),2),i(t,n("Opposite"),3)}))}(Mt),function(t){Z.forEach((function(e){var n=e.name,i=e.attacher;i(t,n("Edge"),"mixed"),i(t,n("DirectedEdge"),"directed"),i(t,n("UndirectedEdge"),"undirected")}))}(Mt),function(t){tt.forEach((function(e){!function(t,e){var n=e.name,i=e.type,o=e.direction;t.prototype[n]=function(t,e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(t,e){if(0===t.size)return[];if("mixed"===e||e===t.type)return"function"==typeof Array.from?Array.from(t._edges.keys()):F(t._edges.keys(),t._edges.size);for(var n,i,o="undirected"===e?t.undirectedSize:t.directedSize,r=new Array(o),s="undirected"===e,a=t._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(r[l++]=i.key);return r}(this,i);if(1===arguments.length){t=""+t;var r=this._nodes.get(t);if(void 0===r)throw new V("Graph.".concat(n,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n,i){var o=[];return lt(!1,t,e,n,i,(function(t){o.push(t)})),o}(this.multi,"mixed"===i?this.type:i,o,r)}if(2===arguments.length){t=""+t,e=""+e;var s=this._nodes.get(t);if(!s)throw new V("Graph.".concat(n,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(n,':  could not find the "').concat(e,'" target node in the graph.'));return function(t,e,n,i,o){var r=[];return ct(!1,t,e,n,i,o,(function(t){r.push(t)})),r}(i,this.multi,o,s,e)}throw new B("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(t,e),function(t,e){var n=e.name,i=e.type,o=e.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[r]=function(t,e,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return at(!1,this,i,n=t);if(2===arguments.length){t=""+t,n=e;var s=this._nodes.get(t);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(t,'" node in the graph.'));return lt(!1,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){t=""+t,e=""+e;var a=this._nodes.get(t);if(!a)throw new V("Graph.".concat(r,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(r,':  could not find the "').concat(e,'" target node in the graph.'));return ct(!1,i,this.multi,o,a,e,n)}throw new B("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);t.prototype[s]=function(){var t,e=Array.prototype.slice.call(arguments),n=e.pop();if(0===e.length){var o=0;"directed"!==i&&(o+=this.undirectedSize),"undirected"!==i&&(o+=this.directedSize),t=new Array(o);var s=0;e.push((function(e,i,o,r,a,l,c){t[s++]=n(e,i,o,r,a,l,c)}))}else t=[],e.push((function(e,i,o,r,s,a,l){t.push(n(e,i,o,r,s,a,l))}));return this[r].apply(this,e),t};var a="filter"+n[0].toUpperCase()+n.slice(1);t.prototype[a]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop(),n=[];return t.push((function(t,i,o,r,s,a,l){e(t,i,o,r,s,a,l)&&n.push(t)})),this[r].apply(this,t),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);t.prototype[l]=function(){var t,e,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new B("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new B("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(t=n[0],e=n[1],n=[]):3===n.length?(t=n[1],e=n[2],n=[n[0]]):4===n.length&&(t=n[2],e=n[3],n=[n[0],n[1]]);var i=e;return n.push((function(e,n,o,r,s,a,l){i=t(i,e,n,o,r,s,a,l)})),this[r].apply(this,n),i}}(t,e),function(t,e){var n=e.name,i=e.type,o=e.direction,r="find"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[r]=function(t,e,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return at(!0,this,i,n=t);if(2===arguments.length){t=""+t,n=e;var s=this._nodes.get(t);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(t,'" node in the graph.'));return lt(!0,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){t=""+t,e=""+e;var a=this._nodes.get(t);if(!a)throw new V("Graph.".concat(r,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(r,':  could not find the "').concat(e,'" target node in the graph.'));return ct(!0,i,this.multi,o,a,e,n)}throw new B("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[s]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop();return t.push((function(t,n,i,o,r,s,a){return e(t,n,i,o,r,s,a)})),!!this[r].apply(this,t)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[a]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop();return t.push((function(t,n,i,o,r,s,a){return!e(t,n,i,o,r,s,a)})),!this[r].apply(this,t)}}(t,e),function(t,e){var n=e.name,i=e.type,o=e.direction,r=n.slice(0,-1)+"Entries";t.prototype[r]=function(t,e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(t,e){if(0===t.size)return N.empty();var n="mixed"!==e&&e!==t.type,i="undirected"===e,o=t._edges.values();return new N((function(){for(var t,e;;){if((t=o.next()).done)return t;if(e=t.value,!n||e.undirected===i)break}return{value:{edge:e.key,attributes:e.attributes,source:e.source.key,target:e.target.key,sourceAttributes:e.source.attributes,targetAttributes:e.target.attributes,undirected:e.undirected},done:!1}}))}(this,i);if(1===arguments.length){t=""+t;var n=this._nodes.get(t);if(!n)throw new V("Graph.".concat(r,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){var i=N.empty();return"undirected"!==t&&("out"!==e&&void 0!==n.in&&(i=Q(i,it(n.in))),"in"!==e&&void 0!==n.out&&(i=Q(i,it(n.out,e?void 0:n.key)))),"directed"!==t&&void 0!==n.undirected&&(i=Q(i,it(n.undirected))),i}(i,o,n)}if(2===arguments.length){t=""+t,e=""+e;var s=this._nodes.get(t);if(!s)throw new V("Graph.".concat(r,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(r,':  could not find the "').concat(e,'" target node in the graph.'));return function(t,e,n,i){var o=N.empty();return"undirected"!==t&&(void 0!==n.in&&"out"!==e&&i in n.in&&(o=Q(o,st(n.in,i))),void 0!==n.out&&"in"!==e&&i in n.out&&(e||n.key!==i)&&(o=Q(o,st(n.out,i)))),"directed"!==t&&void 0!==n.undirected&&i in n.undirected&&(o=Q(o,st(n.undirected,i))),o}(i,o,s,e)}throw new B("Graph.".concat(r,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(t,e)}))}(Mt),function(t){ht.forEach((function(e){(function(t,e){var n=e.name,i=e.type,o=e.direction;t.prototype[n]=function(t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];t=""+t;var e=this._nodes.get(t);if(void 0===e)throw new V("Graph.".concat(n,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){if("mixed"!==t){if("undirected"===t)return Object.keys(n.undirected);if("string"==typeof e)return Object.keys(n[e])}var i=[];return pt(!1,t,e,n,(function(t){i.push(t)})),i}("mixed"===i?this.type:i,o,e)}})(t,e),function(t,e){var n=e.name,i=e.type,o=e.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[r]=function(t,e){if("mixed"===i||"mixed"===this.type||i===this.type){t=""+t;var n=this._nodes.get(t);if(void 0===n)throw new V("Graph.".concat(r,': could not find the "').concat(t,'" node in the graph.'));pt(!1,"mixed"===i?this.type:i,o,n,e)}};var s="map"+n[0].toUpperCase()+n.slice(1);t.prototype[s]=function(t,e){var n=[];return this[r](t,(function(t,i){n.push(e(t,i))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);t.prototype[a]=function(t,e){var n=[];return this[r](t,(function(t,i){e(t,i)&&n.push(t)})),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);t.prototype[l]=function(t,e,n){if(arguments.length<3)throw new B("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[r](t,(function(t,n){i=e(i,t,n)})),i}}(t,e),function(t,e){var n=e.name,i=e.type,o=e.direction,r=n[0].toUpperCase()+n.slice(1,-1),s="find"+r;t.prototype[s]=function(t,e){if("mixed"===i||"mixed"===this.type||i===this.type){t=""+t;var n=this._nodes.get(t);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(t,'" node in the graph.'));return pt(!0,"mixed"===i?this.type:i,o,n,e)}};var a="some"+r;t.prototype[a]=function(t,e){return!!this[s](t,e)};var l="every"+r;t.prototype[l]=function(t,e){return!this[s](t,(function(t,n){return!e(t,n)}))}}(t,e),function(t,e){var n=e.name,i=e.type,o=e.direction,r=n.slice(0,-1)+"Entries";t.prototype[r]=function(t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();t=""+t;var e=this._nodes.get(t);if(void 0===e)throw new V("Graph.".concat(r,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){if("mixed"!==t){if("undirected"===t)return mt(null,n,n.undirected);if("string"==typeof e)return mt(null,n,n[e])}var i=N.empty(),o=new ut;return"undirected"!==t&&("out"!==e&&(i=Q(i,mt(o,n,n.in))),"in"!==e&&(i=Q(i,mt(o,n,n.out)))),"directed"!==t&&(i=Q(i,mt(o,n,n.undirected))),i}("mixed"===i?this.type:i,o,e)}}(t,e)}))}(Mt);var _t=function(t){function n(e){var n=a({type:"directed"},e);if("multi"in n&&!1!==n.multi)throw new B("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new B('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(Mt),It=function(t){function n(e){var n=a({type:"undirected"},e);if("multi"in n&&!1!==n.multi)throw new B("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new B('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(Mt),Lt=function(t){function n(e){var n=a({multi:!0},e);if("multi"in n&&!0!==n.multi)throw new B("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return t.call(this,n)||this}return e(n,t),n}(Mt),Nt=function(t){function n(e){var n=a({type:"directed",multi:!0},e);if("multi"in n&&!0!==n.multi)throw new B("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new B('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(Mt),Pt=function(t){function n(e){var n=a({type:"undirected",multi:!0},e);if("multi"in n&&!0!==n.multi)throw new B("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new B('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(Mt);function $t(t){t.from=function(e,n){var i=a({},e.options,n),o=new t(i);return o.import(e),o}}return $t(Mt),$t(_t),$t(It),$t(Lt),$t(Nt),$t(Pt),Mt.Graph=Mt,Mt.DirectedGraph=_t,Mt.UndirectedGraph=It,Mt.MultiGraph=Lt,Mt.MultiDirectedGraph=Nt,Mt.MultiUndirectedGraph=Pt,Mt.InvalidArgumentsGraphError=B,Mt.NotFoundGraphError=V,Mt.UsageGraphError=W,Mt}()},944:(t,e)=>{"use strict";e.Vb=void 0,e.Vb=function(t,e,n){var i=function(t,e,n){if(0===t.length||0===e.length)return 0;if(n&&!n.caseSensitive&&(t=t.toUpperCase(),e=e.toUpperCase()),t===e)return 1;for(var i=0,o=t.length,r=e.length,s=Math.floor(Math.max(o,r)/2)-1,a=new Array(o),l=new Array(r),c=0;c<o;c++)for(var h=Math.max(0,c-s);h<=Math.min(r,c+s+1);h++)if(!a[c]&&!l[h]&&t[c]===e[h]){++i,a[c]=l[h]=!0;break}if(0===i)return 0;var u=0,d=0;for(c=0;c<o;c++)if(a[c]){for(;!l[d];)d++;t.charAt(c)!==e.charAt(d++)&&u++}return(i/o+i/r+(i-(u/=2))/i)/3}(t,e,n),o=0;if(i>.7){for(var r=Math.min(t.length,e.length),s=0;t[s]===e[s]&&s<4&&s<r;)++o,s++;i+=.1*o*(1-i)}return i}},7106:t=>{"use strict";var e=t.exports=function(t,e,i){"function"==typeof e&&(i=e,e={}),n(e,"function"==typeof(i=e.cb||i)?i:i.pre||function(){},i.post||function(){},t,"",t)};function n(t,i,o,r,s,a,l,c,h,u){if(r&&"object"==typeof r&&!Array.isArray(r)){for(var d in i(r,s,a,l,c,h,u),r){var p=r[d];if(Array.isArray(p)){if(d in e.arrayKeywords)for(var m=0;m<p.length;m++)n(t,i,o,p[m],s+"/"+d+"/"+m,a,s,d,r,m)}else if(d in e.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(t,i,o,p[f],s+"/"+d+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,s,d,r,f)}else(d in e.keywords||t.allKeys&&!(d in e.skipKeywords))&&n(t,i,o,p,s+"/"+d,a,s,d,r)}o(r,s,a,l,c,h,u)}}e.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},e.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},e.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},e.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:t=>{"use strict";var e=[];function n(t){for(var n=-1,i=0;i<e.length;i++)if(e[i].identifier===t){n=i;break}return n}function i(t,i){for(var r={},s=[],a=0;a<t.length;a++){var l=t[a],c=i.base?l[0]+i.base:l[0],h=r[c]||0,u="".concat(c," ").concat(h);r[c]=h+1;var d=n(u),p={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)e[d].references++,e[d].updater(p);else{var m=o(p,i);i.byIndex=a,e.splice(a,0,{identifier:u,updater:m,references:1})}s.push(u)}return s}function o(t,e){var n=e.domAPI(e);return n.update(t),function(e){if(e){if(e.css===t.css&&e.media===t.media&&e.sourceMap===t.sourceMap&&e.supports===t.supports&&e.layer===t.layer)return;n.update(t=e)}else n.remove()}}t.exports=function(t,o){var r=i(t=t||[],o=o||{});return function(t){t=t||[];for(var s=0;s<r.length;s++){var a=n(r[s]);e[a].references--}for(var l=i(t,o),c=0;c<r.length;c++){var h=n(r[c]);0===e[h].references&&(e[h].updater(),e.splice(h,1))}r=l}}},7659:t=>{"use strict";var e={};t.exports=function(t,n){var i=function(t){if(void 0===e[t]){var n=document.querySelector(t);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(t){n=null}e[t]=n}return e[t]}(t);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540:t=>{"use strict";t.exports=function(t){var e=document.createElement("style");return t.setAttributes(e,t.attributes),t.insert(e,t.options),e}},5056:(t,e,n)=>{"use strict";t.exports=function(t){var e=n.nc;e&&t.setAttribute("nonce",e)}},7825:t=>{"use strict";t.exports=function(t){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var e=t.insertStyleElement(t);return{update:function(n){!function(t,e,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var o=void 0!==n.layer;o&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,o&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var r=n.sourceMap;r&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(r))))," */")),e.styleTagTransform(i,t,e.options)}(e,t,n)},remove:function(){!function(t){if(null===t.parentNode)return!1;t.parentNode.removeChild(t)}(e)}}}},1113:t=>{"use strict";t.exports=function(t,e){if(e.styleSheet)e.styleSheet.cssText=t;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(t))}}},6723:(t,e,n)=>{"use strict";n.r(e),n.d(e,{GetRegionEditor:()=>mo,SeqActivityCliffsEditor:()=>yo,SeqPaletteCustom:()=>ro,SequenceSpaceEditor:()=>go,SplitToMonomersEditor:()=>fo,SubsequenceSearchTopMenu:()=>Qo,_package:()=>io,activityCliffs:()=>Io,addCopyMenu:()=>yr,alignSequences:()=>Go,bioSubstructureFilter:()=>lr,bioSubstructureFilterTest:()=>cr,compositionAnalysis:()=>Fo,compositionAnalysisWidget:()=>Ao,convertColumnAction:()=>Wo,convertDialog:()=>Vo,customSequenceCellRenderer:()=>bo,demoBioActivityCliffs:()=>wr,demoBioAtomicLevel:()=>Cr,demoBioSequenceSpace:()=>vr,demoBioSimilarityDiversity:()=>br,detectMacromoleculeProbe:()=>Er,diversitySearchTopMenu:()=>Xo,diversitySearchViewer:()=>Zo,fastaSequenceCellRenderer:()=>vo,getBioLib:()=>co,getHelmMonomers:()=>zo,getMolFromHelm:()=>Mr,getMonomerLibHelper:()=>oo,getRegion:()=>Mo,getRegionApp:()=>dr,getRegionHelmApp:()=>pr,getRegionPanel:()=>uo,getRegionTopMenu:()=>_o,getSeqHandler:()=>ho,getSeqHelper:()=>Tr,helmPreprocessingFunction:()=>No,importBam:()=>Bo,importFasta:()=>Do,initBio:()=>ao,libraryPanel:()=>po,longSeqTableFasta:()=>fr,longSeqTableHelm:()=>gr,longSeqTableSeparator:()=>mr,macroMolColumnPropertyPanel:()=>Co,macromoleculeDifferenceCellRenderer:()=>So,macromoleculePreprocessingFunction:()=>Lo,manageLibrariesView:()=>ir,manageMonomerLibraries:()=>nr,manageMonomerLibrariesView:()=>rr,manageMonomerLibrariesViewTreeBrowser:()=>sr,manageMonomersView:()=>or,monomerCellRenderer:()=>Uo,multipleSequenceAlignmentDialog:()=>Ho,saveAsFasta:()=>ar,sdfToJsonLib:()=>Ar,searchSubsequenceEditor:()=>Jo,separatorSequenceCellRenderer:()=>wo,seq2atomic:()=>Sr,seqIdentity:()=>xr,sequence3dStructureWidget:()=>Oo,sequenceAlignment:()=>xo,sequenceIdentityScoring:()=>tr,sequenceSimilarityScoring:()=>er,sequenceSpaceTopMenu:()=>Po,sequenceTooltip:()=>lo,similaritySearchTopMenu:()=>Ko,similaritySearchViewer:()=>Yo,splitToMonomersTopMenu:()=>qo,test1:()=>_r,testDetectMacromolecule:()=>jo,toAtomicLevel:()=>$o,toAtomicLevelAction:()=>Ro,toAtomicLevelPanel:()=>ko,vdRegionsViewer:()=>To,webLogoAggApp:()=>ur,webLogoLargeApp:()=>hr,webLogoViewer:()=>Eo});var i,o,r=n(4328),s=n(7389),a=n(6082),l=n(684),c=n(9039);(o=i||(i={})).EUCLIDEAN="EUCLIDEAN",o.MANHATTAN="MANHATTAN";var h=n(1858),u=n(5072),d=n.n(u),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),b=n.n(y),v=n(540),w=n.n(v),C=n(1113),A=n.n(C),S=n(7939),x={};x.styleTagTransform=A(),x.setAttributes=b(),x.insert=g().bind(null,"head"),x.domAPI=m(),x.insertStyleElement=w(),d()(S.A,x),S.A&&S.A.locals&&S.A.locals;var E=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};let T=null,M=null;function _(t,e){return t&&""!=t?t:e}n(2780);class I{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n    the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n  used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return E(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!T&&(T=yield navigator.gpu.requestAdapter(),null==T))return null;let t=null;return"info"in T&&(t=T.info),t?_(t.description,_(t.vendor,"No GPU description available")):"No GPU description available"}))}().then((t=>{t?(this.useWebGPU.tooltip+=` (${t})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const N="MCL";var P=n(1991),$=n.n(P);a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class R{constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class k{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((n=>{null!=t[n].value&&(e[n]=t[n].value)})),e}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(t={}){this.editorSettings={},this.plotEmbeddingsInput=s.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=s.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[c.c.UMAP,c.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=s.inputs([]),this.dbScanSettingsDiv=s.inputs([]),this.preprocessingFuncSettingsDiv=s.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.c.UMAP]:new I,[c.c.T_SNE]:new L},this.dbScanParams=new R,this.editorSettings=t,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.GP]}).forEach((t=>{const e=t.options.get(l.n3)??"",n=t.friendlyName??t.name,i=t.options.get(l.C0)??"",o=t.options.get(l._X)??"",r=t.options.get(l.Gi)??"";this.editorSettings.semtype&&!e.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!o.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:t,semTypes:e?e.split(","):[],types:i?i.split(","):[],units:o?o.split(","):[],distanceFunctions:r?r.split(","):[]})})),this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,items:r.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let e=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:t=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[t])}}),this.methodSettingsIcon=s.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let o=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,o=!0),o||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((t=>this.preprocessingFunctionInputRoot.append(t)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let h=!1;this.preprocessingFuncSettingsIcon=s.icons.settings((async()=>{h?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),h=!h}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const t=this.tableInput.value?.columns.toList().find((t=>!!this.columnFunctionsMap[t.name]))??null,e=s.input.column("Column",{table:this.tableInput.value,value:t,nullable:!1,onValueChanged:()=>this.onColumnInputChanged(),filter:t=>!!this.columnFunctionsMap[t.name]});return this.colInputRoot||(this.colInputRoot=e.root),e}regenerateColInput(){let t=!1;this.colInputRoot&&(t=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),t&&Array.from(this.colInput.root.children).forEach((t=>this.colInputRoot.append(t))),this.onColumnInputChanged()}onTableInputChanged(){const t=this.tableInput.value;if(!t)return;const e=()=>{this.columnFunctionsMap={},t.columns.toList().forEach((t=>{Object.keys(this.supportedFunctions).forEach((e=>{const n=this.supportedFunctions[e].semTypes,i=this.supportedFunctions[e].types,o=this.supportedFunctions[e].units,r=!n.length||t.semType&&n.includes(t.semType),s=!i.length||i.includes(t.type),a=!o.length||t.meta.units&&o.includes(t.meta.units);r&&s&&a&&(this.columnFunctionsMap[t.name]||(this.columnFunctionsMap[t.name]=[]),this.columnFunctionsMap[t.name].push(e))}))})),this.regenerateColInput()};e(),$()(t.columns).some((t=>!!t.getTag(a.Tags.SemanticDetectionDuration)))||t.meta.detectSemanticTypes().then((()=>{e()}))}onColumnInputChanged(){const t=this.colInput.value;if(!t)return;const e=this.columnFunctionsMap[t.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:e[0],items:e,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((t=>this.preprocessingFunctionInputRoot.append(t)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const t=this.preprocessingFunctionInput.value,e=this.supportedFunctions[t].distanceFunctions;this.availableMetrics=[...e],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((t=>this.similarityMetricInputRoot.append(t))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[t].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(t,e){return s.empty(t),Object.keys(e).forEach((n=>{const i=e[n],o="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:t=>{i.value=t}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:t=>{i.value=t}}):s.input.float(i.uiName,{value:i.value,onValueChanged:t=>{i.value=t}});t.append(o.root),i.disable?(o.enabled=!1,s.tooltip.bind(o.input??o.root,i.disableTooltip??"")):s.tooltip.bind(o.input??o.root,i.tooltip)})),t}async createPreprocessingFuncParamsDiv(t,e){if(s.empty(t),e.inputs.length<3)return s.div();const n=e.prepare(),i=await n.buildEditor(s.div());for(let o=2;o<e.inputs.length;o++){const r=e.inputs[o];(this.preprocessingFunctionSettings[r.name]||n.inputParams[e.inputs[o].name].value||r.defaultValue)&&(this.preprocessingFunctionSettings[r.name]=this.preprocessingFunctionSettings[r.name]??n.inputParams[r.name].value??r.defaultValue);const s=i.find((t=>t.property.name===r.name));s&&(null!==this.preprocessingFunctionSettings[r.name]&&void 0!==this.preprocessingFunctionSettings[r.name]&&(s.value=this.preprocessingFunctionSettings[r.name]),s.onChanged.subscribe((t=>{this.preprocessingFunctionSettings[r.name]=t})),t.append(s.root))}return t}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(t){try{const e=JSON.parse(t);await this.applyInput(e)}catch(t){r.shell.error("Error applying input from history"),console.error(t)}}async applyInput(t){try{const e=this.tableInput.value?.col(t.col);if(!e)throw new Error("Column not found");this.colInput.value=e,this.preprocessingFunctionInput.value=t.preprocessingFunction,this.similarityMetricInput.value=t.similarityMetric,this.plotEmbeddingsInput.value=t.plotEmbeddings,this.clusterEmbeddingsInput.value=t.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((e=>{null!=t.options[e]&&(this.methodsParams[t.methodName][e].value=t.options[e])})),this.methodInput.value=t.methodName,this.preprocessingFunctionSettings=t.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(t){r.shell.error("Error applying input from history"),console.error(t)}}}var O=n(9713),H=n(6295);const G=t=>null==t;function F(t,e,n,i){if(n>t[t.length-1])return;const o=t.findIndex((t=>n<t));t.pop(),t.splice(o,0,n),e.pop(),e.splice(o,0,i)}class D{constructor(t=!0,e=!0){const i=navigator.hardwareConcurrency;this._workerCount=t?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=e}async calc(t,e,n=!0,o){return await this.calcMulti([t],[e],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(t,e,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(t.length<1)throw new Error("values must contain at least one array");if(e.length!==t.length||o.length!==t.length||r.length!==t.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=t[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),g=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:t,fnNames:e,startRow:y,startCol:b,chunckSize:g-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise(((t,e)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),o?e(o):(u.set(r,i),s<m&&(m=s),a>f&&(f=a),t())}}))}await Promise.all(l),n&&u.forEach(((t,e)=>{u[e]=(t-m)/(f-m)})),i(u)}catch(t){a(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}class B{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(t,e=1e6){const n=200,i=new Uint32Array(n),o=t.distance.length,r=t.distance;for(let t=0;t<o;t++)i[Math.floor(r[t]*n)]++;let s=0,a=0;for(let t=0;t<n&&(s+=i[t],a=t,!(s>=e));t++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=t.i,d=t.j;let p=0;const m=(a+1)/n;for(let t=0;t<o;t++)r[t]<m&&(l[p]=u[t],c[p]=d[t],h[p]=r[t],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(t,e,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=t[0].length>2e4?await this.getMinimalThreshold(t,e,r,s,a):0;o<h&&(console.log(`using threshold ${h}`),o=h),r.forEach(((t,e)=>r[e].threshold=o));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:t,startIdx:u,endIdx:p,threshold:o,fnNames:e,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:t,i:e,j:o,distance:r}})=>{t?(d[n].terminate(),h(t)):(d[n].terminate(),i({i:e,j:o,distance:r,idx:n}))}}));const p=await Promise.all(u),m=p.reduce(((t,e)=>t+e.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const t of p)f.set(t.i,b),g.set(t.j,b),y.set(t.distance,b),b+=t.i.length;return{i:f,j:g,distance:y}}async calc(t,e,n,i={}){return await this.calcMultiColumn([t],[e],n,[i],[1])}async getKNN(t,e,n=15,i={}){return await this.multiColumnKNN([t],[e],n,[i],[1])}async getThresholdKNN(t,e,n=.8,i={}){return await this.multiColumnThresholdKnn([t],[e],n,[i],[1])}async multiColumnThresholdKnn(t,e,o=.8,r,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==r.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:r,threshold:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:o}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:o}))}}));const d=await Promise.all(h),p=new Int32Array(t[0].length);for(const e of d)for(let n=0;n<t[0].length;++n)p[n]+=e.knnIndexes[n]?.length??0;const m={knnDistances:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e]))),knnIndexes:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e])))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)m.knnDistances[n][p[n]-1]=e.knnDistances[n][t],m.knnIndexes[n][p[n]-1]=e.knnIndexes[n][t],p[n]-=1;return m}async multiColumnSingleValueKNN(t,e,o,r=15,s,a,l=i.EUCLIDEAN){if(t.length!==o.length||t.length!==s.length||t.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),h=new Array(this._workerCount),u=t[0].length,d=t.map((t=>t[e])),p=Math.ceil(u/this._workerCount);for(let e=0;e<this._workerCount;e++)h[e]=new Promise(((n,i)=>{const h=e*p,m=e===this._workerCount-1?u:(e+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[e].postMessage({values:t.map((t=>t.slice(h,m))),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:h}),c[e].onmessage=({data:{error:t,knnDistances:o,knnIndexes:r}})=>{t?(c[e].terminate(),i(t)):(c[e].terminate(),n({knnDistances:o,knnIndexes:r}))}}));const m=await Promise.all(h),f={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const t of m)for(let e=0;e<(t.knnDistances?.length??0);++e)F(f.knnDistances,f.knnIndexes,t.knnDistances[e],t.knnIndexes[e]);return f}async multiColumnKNN(t,e,o=15,r,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==r.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:o}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:o}))}}));const d=await Promise.all(h),p={knnDistances:new Array(t[0].length).fill(null).map((()=>new Array(o).fill(99999))),knnIndexes:new Array(t[0].length).fill(null).map((()=>new Array(o).fill(-1)))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)F(p.knnDistances[n],p.knnIndexes[n],e.knnDistances[n][t],e.knnIndexes[n][t]);return p}async getSampleDistances(t,e,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=t[0].length*(t[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:t,startIdx:d,endIdx:p,sampleLength:h,fnNames:e,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:t,distance:e}})=>{a[l].terminate(),t?u(t):c({distance:e})}}));const d=await Promise.all(u),p=d.reduce(((t,e)=>t+e.distance.length),0),m=new Float32Array(p);let f=0;for(const t of d)m.set(t.distance,f),f+=t.distance.length;return m.sort(),m}catch(t){return a?.forEach((t=>t?.terminate())),console.error(t),new Float32Array(1).fill(.5)}}async getMinimalThreshold(t,e,n=[],o,r=i.EUCLIDEAN){try{const i=t.length*(t.length-1)/2,s=await this.getSampleDistances(t,e,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(t){return console.error(t),.5}}static calcSync(t,e,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const h=t.length*(t.length-1)/2;for(;a<h;){const e=G(t[l])||G(t[c])?1:n(t[l],t[c]);1-e>=i&&(o.push(l),r.push(c),s.push(e)),a++,c++,c===t.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var V,W,U=n(8774);(W=V||(V={})).none="none",W.bold="bold",W.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(t){t!==this._currentLineIdx&&(this._currentLineIdx=t,this.sp.render(this.ctx))}set linesToRender(t){this.updateLines(t),this.sp.render(this.ctx)}set linesVisibility(t){this.visibility=t,this.sp.render(this.ctx)}constructor(t,e,n,i,o=V.none){var r;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=t,this.xAxisCol=this.sp.dataFrame.columns.byName(e),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new U.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=t=>{var e;(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(t.offsetX,t.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},this.canvas.onmousemove=t=>{var e;this.mouseOverLineId=(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)?-1:this.checkCoordsOnLine(t.offsetX,t.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},t.onEvent("d4-before-draw-scene").subscribe((t=>{this.renderLines()}))}updateLines(t){this.lines=t,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),t.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var t,e,n,i,o,r,s,a,l,c,h,u,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(t=this.lines.width)&&void 0!==t?t:1,this.ctx.strokeStyle=`rgba(${null!==(e=this.lines.color)&&void 0!==e?e:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let t=0;t<this.lines.from.length;t++)if(b.get(this.lines.from[t])&&b.get(this.lines.to[t])&&this.visibility.getBit(t)){let e=0;const n=this.sp.getMarkerSize(this.lines.from[t])/2,i=this.sp.getMarkerSize(this.lines.to[t])/2,b=this.sp.pointToScreen(this.lines.from[t]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[t]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const e=(null===(o=this.lines.colors)||void 0===o?void 0:o[t])?null===(r=this.lines.colors)||void 0===r?void 0:r[t]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[t])?null===(l=this.lines.opacities)||void 0===l?void 0:l[t]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${e},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[t])?null===(u=this.lines.widths)||void 0===u?void 0:u[t]:null!==(d=this.lines.width)&&void 0!==d?d:1}t===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[t];let A=null;if(b){e=this.getLineLength(w,C,S,x);const o=this.getPointOnDistance(w,C,S,x,i,e),r=this.getPointOnDistance(S,x,w,C,n,e);w=o.x,C=o.y,S=r.x,x=r.y,A=this.lines.from[t]>this.lines.to[t]?this.findControlPoint(b,w,C,S,x,t):this.findControlPoint(b,S,x,w,C,t),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(t))&&(e||(e=this.getLineLength(w,C,S,x)),e>this.arrowWidth)){const t=b?null:this.getPointOnDistance(w,C,S,x,i,e),n=b?A.x:w,o=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==t?void 0:t.x)&&void 0!==f?f:w,null!==(g=null==t?void 0:t.y)&&void 0!==g?g:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),t===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(t){switch(this.currentLineStyle){case V.bold:t?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:t?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const t=new Path2D;t.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(t),this.ctx.closePath()}createMultiLinesIndices(){const t={};for(let e=0;e<this.lines.from.length;e++){let n=0,i=0;this.lines.from[e]<this.lines.to[e]?(n=this.lines.from[e],i=this.lines.to[e]):(n=this.lines.to[e],i=this.lines.from[e]),t[`${n}|${i}`]?(1===t[`${n}|${i}`].length&&(this.multipleLinesCounts[t[`${n}|${i}`][0]]=1,t[`${n}|${i}`].push(1)),this.multipleLinesCounts[e]=++t[`${n}|${i}`][1]):t[`${n}|${i}`]=[e]}}checkCoordsOnLine(t,e){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,t,e,i,h,u)}else o=this.calculateDistToStraightLine(t,e,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(t,e,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return t>=o-2&&t<=r+2&&e>=s-2&&e<=a+2?this.distToStraightLineSegment(t,e,n,i):null}distToStraightLineSegment(t,e,n,i){const o=(t,e,n,i)=>Math.pow(t-n,2)+Math.pow(e-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(t,e,n.x,n.y);let s=((t-n.x)*(i.x-n.x)+(e-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(t,e,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(t,e,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(e>=s-2&&e<=a+2&&n>=l-2&&n<=c+2){const t=a-s,h=c-l;return this.calculateDistToCurveInRect(e,n,i,r,o,t,h)}return null}calculateDistToCurveInRect(t,e,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new U.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(t-a),f=Math.abs(e-p),g=m+f;(!d||d>g)&&(d=g),u[r]=Math.max(m,f),c[r]=a,h[r]=p}for(let t=0;t<c.length;t++)u[t]<d&&p.setBit(t,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-t,h[n]-e);(!m||m>i)&&(m=i)}return m}getLineLength(t,e,n,i){return Math.sqrt(Math.pow(n-t,2)+Math.pow(i-e,2))}getPointOnDistance(t,e,n,i,o,r){const s=n-o*((n-t)/r),l=i-o*((i-e)/r);return new a.Point(s,l)}findControlPoint(t,e,n,i,o,r){const s=e+(i-e)/2,l=n+(o-n)/2;let c=s-e,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(t/2);return t%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(t,e,n,i,o){const r=Math.atan2(i-e,o-n)+Math.PI;t.moveTo(e-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),t.lineTo(e,n),t.lineTo(e-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}var q,z,Y=n(8060),K=n(3629);async function Z(t,e,i,o,s,a,l){let c=await async function(t,e,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(t.length!==e.length||t.length!==a.distanceFnArgs.length||t.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:t,distanceMetrics:e,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(Y.S).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:t,embedding:e,epochNum:n,epochsLength:i}})=>{G(n)||G(i)?(d.unsubscribe(),t?h(t):c(e),setTimeout((()=>u.terminate()),100)):l&&l(n,i,e)}}))}(t,i,e,o,s,a,l);return c=c.map((t=>(0,K.S8)(t))),c}(z=q||(q={})).EUCLIDEAN="EUCLIDEAN",z.MANHATTAN="MANHATTAN";const X={[q.EUCLIDEAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[q.MANHATTAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const tt={[J.HAMMING]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[J.EUCLIDEAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(t,e){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(t,e){return`\n      let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${t+1}u>;\n      var horizontalGaps: array<u32, ${t+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${e};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${e};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${e}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${e}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[J.SOKAL]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(t,e){return`\n    let range = suppInfo.range${e};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},et={[J.HAMMING]:t=>Math.ceil(t/30),[J.EUCLIDEAN]:t=>Math.ceil(t/30),[J.MANHATTAN]:t=>Math.ceil(t/30),[J.TANIMOTO]:t=>Math.ceil(t/30),[J.SOKAL]:t=>Math.ceil(t/30),[J.COSINE]:t=>Math.ceil(t/30),[J.ASYMMETRIC]:t=>Math.ceil(t/30),[J.LEVENSTEIN]:t=>Math.ceil(t*t/60),[J.NEEDLEMAN_WUNSCH]:t=>Math.ceil(t*t/60),[J.MONOMER_CHEMICAL_DISTANCE]:t=>Math.ceil(t/25),[J.Difference]:t=>1,[J.OneHot]:t=>Math.ceil(t/40),[J.VECTOR_COSINE]:t=>Math.ceil(t/30)},nt={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};var it=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function ot(t,e,n,i){return t.map(((t,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${tt[t](e[i],i)}\n        }\n      `)).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${t.length}>;\n        ${t.map(((t,e)=>`distances[${e}] = distanceScript${e}(aIndex, bIndex);`)).join("\n")}\n        ${X[i](t.length)}\n      }\n    \n    `}let rt=0;const st="cliffsDf",at=new h.Subject,lt="Δ activity",ct="SALI",ht="Similarity",ut="line index",dt=["From","To"],pt="filterCliffs";async function mt(t,e,i,o,l,c,h,u,d,p,m,f,g,y,b,v,w){rt++;const C=c/100;let A,S=!1;const x=f.inputs,_=await f.apply({[x[0].name]:e,[x[1].name]:h,...d.preprocessingFuncArgs??{}});let I=[];if(u===N){const e=await function(t,e,i,o,r,s,a=10,l=!1,c=2){const h=new Worker(new URL(n.p+n.u(980),n.b));let u;return h.postMessage({data:t,threshold:e,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((t,e)=>{u=t,h.onmessage=e=>{setTimeout((()=>h.terminate()),100),t(e.data.res)},h.onerror=t=>{setTimeout((()=>h.terminate()),100),e(t)}})),terminate:()=>{try{u(null),h.terminate()}catch(t){console.error(t)}}}}([_.entries],c,[1],"MANHATTAN",[h],[_.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;t.columns.addNewInt(t.columns.getUnusedName("MCL Cluster")).init((t=>e.clusters[t])),I=[e.embedX,e.embedY]}else I=await Z([_.entries],u,[h],[1],"MANHATTAN",{...d,distanceFnArgs:[_.options??{}]});if(I.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let e=0;e<I.length;++e)t.columns.addNewFloat(i[e]).init((t=>I[e][t]));let L=null;if(d.useWebGPU)try{L=await function(t,e=.8,n,i,o,r){return it(this,void 0,void 0,(function*(){const s=yield function(){return E(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!T&&(T=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==T))return null;let t=!1;if(M&&(M.lost.then((()=>{t=!0})),yield new Promise((t=>setTimeout(t,10)))),!M||t){const t=1e9,e=T.limits,n=e.maxBufferSize,i=e.maxStorageBufferBindingSize;try{return M=yield T.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,t),maxStorageBufferBindingSize:Math.min(i,t)}}),M}catch(t){return console.error("Failed to create device with required limits",t),M=yield T.requestDevice(),M}}return M}))}();if(!s)return null;const a=Object.values(J);if(n.some((t=>!a.includes(t))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(q).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-e;if(r.length!==t.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(t.some((e=>e.length!==t[0].length)))throw new Error("All entry lists must be the same length");const c=t.length,h=t[0].length,u=t.map(((t,e)=>function(t,e=J.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=t.some((t=>"string"==typeof t))?(s="STRING",t.map((t=>new Uint32Array(t.split("").map((t=>t.charCodeAt(0))))))):t.some((t=>"number"==typeof t))?(s="NUMBER",t.map((t=>new Float32Array([t])))):"object"==typeof t[0]&&t.some((t=>"_data"in t&&"_length"in t))?(s="BITARRAY",t.map((t=>t._data))):t.some((t=>t instanceof Float32Array))?(s="FLOAT32ARRAY",t):t.some((t=>t instanceof Uint32Array))?(s="UINT32ARRAY",t):t.some((t=>t instanceof Int32Array))?(s="INT32ARRAY",t):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((t=>t.length)));if(!nt[s]||!nt[s].has(e))throw new Error(`Distance metric '${e}' not supported for entry type '${s}'`);const h=c.reduce(((t,e)=>Math.max(t,e)),0),u=et[e](h),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*h);a.forEach(((t,e)=>{p.set(t,e*h)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(e===J.NEEDLEMAN_WUNSCH||e===J.MONOMER_CHEMICAL_DISTANCE){let t=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((t,e)=>Math.max(t,e.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let e=0;e<p.length;e++)p[e]>t&&(t=p[e]);i.scoringMatrix=new Array(t+1).fill(null).map((()=>new Array(t+1).fill(0))),i.alphabetIndexes={};for(let t=0;t<i.scoringMatrix.length;t++)i.scoringMatrix[t][t]=1,i.alphabetIndexes[String.fromCharCode(t)]=t}const e=(t+1)*(t+1),s=new Array(t+1).fill(null).map((()=>new Float32Array(t+1)));for(let e=0;e<t+1;e++)s[e][e]=1;const a=i.alphabetIndexes;for(const t of Object.keys(a))for(const e of Object.keys(a))t!==e&&(s[t.charCodeAt(0)][e.charCodeAt(0)]=i.scoringMatrix[a[t]][a[e]]);f=2+e,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let t=0;t<s.length;t++)y.set(s[t],l),l+=s[t].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${t+1}>, ${t+1}>`}else if(e===J.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const t=p.reduce(((t,e)=>Math.min(t,e)),p[0]),e=p.reduce(((t,e)=>Math.max(t,e)),p[0]);i.range=e-t}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(t,n[e],e,r[e])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=q.MANHATTAN);let d=u.map((t=>t.suppInfoStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map((t=>t.dataStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),f=new Uint32Array(c*h);u.forEach(((t,e)=>{f.set(t.arraySizes,e*h)}));const g=1e4,y=100,b=u.reduce(((t,e)=>t+e.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=h*(h-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${S} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${ot(n,u.map((t=>t.maxEntryLen)),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),P=new Uint32Array(g),$=Math.floor(A/g);let R=0,k=1;console.time("GPUthreadStarts");for(let t=0;t<g;t++){const e=9999===t?A-1:(t+1)*$,n=h-2-Math.floor(Math.sqrt(-8*e+4*h*(h-1)-7)/2-.5),i=e-h*n+Math.floor((n+1)*(n+2)/2);I[t]=k,L[t]=R,N[t]=i,P[t]=n,R=n,k=i}console.timeEnd("GPUthreadStarts");const O=4e4+h*c+c+u.reduce(((t,e)=>t+e.sourceArraySize),0),H=u.reduce(((t,e)=>t+e.suppInfoSize),0),G=1e6,F=O*Uint32Array.BYTES_PER_ELEMENT;let D=F;const B=15&F;0!==B&&(D+=16-B);const V=s.createBuffer({label:"compute info buffer",size:D,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let U=0;new Uint32Array(W,U,g).set(I),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,g).set(L),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,g).set(N),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,g).set(P),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,f.length).set(f),U+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,U,c).set(o),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const t of u){const e=t.EncodedArrayConstructor,n=t.sourceArraySize;new e(W,U,n).set(t.flatSourceArray),U+=n*e.BYTES_PER_ELEMENT}V.unmap();const j=H*Uint32Array.BYTES_PER_ELEMENT;let z=j;const Y=15&j;0!==Y&&(z+=16-Y),z=Math.max(z,16);const K=s.createBuffer({label:"supp info buffer",size:z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),Z=K.getMappedRange();let X=0;for(const t of u)t.suppInfoBuffer&&t.suppInfoBuffer.byteLength>0&&t.suppInfoSize>0&&(new("UINT32ARRAY"===t.suppInfoType?Uint32Array:Float32Array)(Z,X,t.suppInfoBuffer.length).set(t.suppInfoBuffer),X+=t.suppInfoBuffer.byteLength);0===X&&new Uint32Array(Z,0,4).set([1,1,1,1]),K.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let tt=Q;const it=15&Q;0!==it&&(tt+=16-it);const rt=s.createBuffer({label:"results buffer",size:tt,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),st=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:_.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:rt}}]}),at=s.createBuffer({label:"results out buffer",size:rt.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),lt=[],ct=[],ht=[];let ut=!1;for(;!ut;){const t=s.createCommandEncoder({label:"distance encoder"}),e=t.beginComputePass({label:"distance compute pass"});e.setPipeline(_),e.setBindGroup(0,st),e.dispatchWorkgroups(w,w),e.end(),t.copyBufferToBuffer(rt,0,at,0,at.size);const n=t.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield at.mapAsync(GPUMapMode.READ);const i=at.getMappedRange();let o=0;const r=new Uint32Array(i,o,G);o+=G*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,G);o+=G*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,G);o+=G*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,g);o+=g*Uint32Array.BYTES_PER_ELEMENT,ut=new Uint32Array(i,o,g).every((t=>1===t));const h=c.reduce(((t,e)=>t+e),0),u=new Uint32Array(h),d=new Uint32Array(h),p=new Float32Array(h);let m=0;for(let t=0;t<c.length;t++){const e=c[t];0!==e&&(u.set(r.subarray(t*y,t*y+e),m),d.set(a.subarray(t*y,t*y+e),m),p.set(l.subarray(t*y,t*y+e),m),m+=e)}lt.push(u),ct.push(d),ht.push(p),at.unmap()}const dt=lt.reduce(((t,e)=>t+e.length),0),pt=new Uint32Array(dt),mt=new Uint32Array(dt),ft=new Float32Array(dt);let gt=0;for(let t=0;t<lt.length;t++)pt.set(lt[t],gt),mt.set(ct[t],gt),ft.set(ht[t],gt),gt+=lt[t].length;return V.destroy(),K.destroy(),rt.destroy(),at.destroy(),{i:pt,j:mt,distance:ft}}))}([_.entries],C,[h],q.MANHATTAN,[1],[_.options??{}])}catch(t){console.error(t)}L||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),L=await(new B).calc(_.entries,h,C,_.options));const P=await async function(t,e){const n=t.distance.map(((n,i)=>{const o=Math.abs(e.get(t.i[i])-e.get(t.j[i]));return 0!=n?o/n:1/0})),i=t.distance.map((t=>1-t)),o=t.i,r=t.j,s=a.BitSet.create(e.length);return t.distance.forEach(((e,n)=>{s.set(t.i[n],!0),s.set(t.j[n],!0)})),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:s}}(L,l),R=function(t,e,n,i,o,r,s){const l=new Array(t).fill(0);for(let t=0;t!=i.length;++t)n[t]!=1/0&&(s.get(i[t])>s.get(o[t])?l[i[t]]+=n[t]:l[o[t]]+=n[t]);return a.Column.fromList("double",e,l)}(e.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,P.saliVals,P.n1,P.n2,0,l);t.columns.add(R);const k=P.cliffsBitSet,H=function(t){const e=t.filter((t=>t!==1/0)),n=e.reduce(((t,e)=>Math.min(t,e)),Number.MAX_VALUE);return{max:e.reduce(((t,e)=>Math.max(t,e)),n),min:n}}(P.saliVals),G=.8/(H.max-H.min),F=r.shell.getTableView(t.name),D=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:R.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:o}),W=function(t,e,n,i,o,r,s,l){const c={from:new Uint32Array(e.n1.length),to:new Uint32Array(e.n1.length),opacities:new Float32Array(e.n1.length),colors:new Array(e.n1.length),widths:new Float32Array(e.n1.length)};for(let n=0;n<e.n1.length;n++)c.from[n]=e.n1[n],c.to[n]=e.n2[n],c.opacities[n]=e.saliVals[n]===1/0?1:.2+(e.saliVals[n]-s.min)*l,c.colors[n]=t.selection.get(c.from[n])&&t.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return dt.forEach(((t,e)=>{h.columns.addNewString(t).init((t=>n.get(0===e?c.from[t]:c.to[t]))),function(t,e){Object.keys(e).forEach((n=>{t.tags[n]=e[n]}))}(h.col(t),r),h.col(t).semType=o})),h.columns.addNewFloat(lt).init((t=>Math.abs(i.get(c.from[t])-i.get(c.to[t])))),h.columns.addNewInt(ut).init((t=>t)),h.columns.addNewFloat(ct).init((t=>e.saliVals[t])),h.columns.addNewFloat(ht).init((t=>e.simVals[t])),h.name=`${st}${rt}`,{lines:c,linesDf:h}}(t,P,e,l,p,m,H,G);W.lines.skipMultiLineCalculation=!0,W.linesDf.col(ct).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const U=new j(D,i[0],i[1],W.lines,V.none),z=b?b(W.linesDf,dt).sort([ct],[!1]):W.linesDf.plot.grid().sort([ct],[!1]);z.col(ut)&&(z.col(ut).visible=!1),t.temp[".cliffsDfGrid"]=z;const Y=s.button(`${W.linesDf.rowCount} cliffs`,(()=>{const t=$()(F.viewers).some((t=>t.dataFrame.name===`${st}${rt}`));w&&!t&&F.addViewer(z),F.dockManager.dock(z,"down",null,"Activity cliffs",v??.2)}));Y.classList.add("scatter_plot_link","cliffs_grid");const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:e=>{e?(D.dataFrame.setTag(pt,i[0]),t.filter.and(k),at.next(i[0])):(D.dataFrame.setTag(pt,""),t.filter.setAll(!0),at.next(""))}});D.root.prepend(s.divH([Y,K.root],"cliffs_div")),at.subscribe((t=>{K.enabled=""===t||t===i[0]})),t.onRowsFiltering.subscribe((()=>{K.value&&t.filter.and(P.cliffsBitSet)}));const X=r.events.onViewerClosed.subscribe((t=>{t.args.viewer===D&&(F.dockManager.close(z.root),X.unsubscribe(),F.subs=F.subs.filter((t=>t!==X)))}));return F.subs.push(X),W.linesDf.onCurrentCellChanged.subscribe((()=>{for(let t=0;t<W.linesDf.rowCount;t++)W.lines.widths[t]=t===W.linesDf.currentRowIdx?3:1;U.linesToRender=W.lines;const n=W.linesDf.currentCol&&W.linesDf.currentCol.name===dt[1]?W.lines.to:W.lines.from,o=-1!==W.linesDf.currentRowIdx?W.linesDf.currentRowIdx:null;if(D.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=W.linesDf.currentRowIdx;U.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(t,e,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=t/s,c=e/a,h=Math.min(l,c),u=t/h*5,d=e/h*5,p=(n<o?n:o)+s/2-u/2,m=(i>r?i:r)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(D.viewport.width,D.viewport.height,D.dataFrame.get(i[0],W.lines.from[n]),D.dataFrame.get(i[1],W.lines.from[n]),D.dataFrame.get(i[0],W.lines.to[n]),D.dataFrame.get(i[1],W.lines.to[n]));D.zoom(a,h,c,u),K.value?t.filter.and(k):!0===K.enabled&&t.filter.setAll(!0),setTimeout((()=>{!function(t,e,n,i,o,a,l,c,h){const u=e.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:o,df:t,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout((()=>{r.shell.o=e.root}),500)}(t,A,W.lines.from[o],W.lines.to[o],o,e,l,W.linesDf.get(ct,o),y);const n=D.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(e.name,n.indexOf(D.dataFrame.currentRowIdx))}),1e3)}})),W.linesDf.onSelectionChanged.subscribe((e=>{setTimeout((()=>(()=>{const e=a.BitSet.create(t.rowCount);for(let t=0;t<W.linesDf.rowCount;t++){const n=W.linesDf.selection.get(t);n&&(e.set(W.lines.from[t],!0),e.set(W.lines.to[t],!0)),W.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),U.linesToRender=W.lines})()),100)})),t.onSelectionChanged.subscribe((e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(S?S=!1:(t=>{t.selection.setAll(!1);for(let t=0;t<W.lines.colors.length;t++)W.lines.colors[t]="0,128,0";U.linesToRender=W.lines})(z.dataFrame))})),U.lineClicked.subscribe((e=>{if(S=!0,U.currentLineId=e.id,-1!==e.id){const n=W.linesDf.selection.clone();setTimeout((()=>{e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),W.linesDf.selection.copyFrom(n)):(W.linesDf.currentRowIdx!==e.id&&(W.linesDf.currentRowIdx=e.id,t.currentRowIdx=W.lines.from[e.id]),W.linesDf.selection.copyFrom(n));const i=W.linesDf.getSortedOrder(z.sortByColumns,z.sortTypes);z.scrollToCell(dt[0],i.indexOf(e.id))}),500)}})),U.lineHover.pipe((0,O.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===t.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[W.lines.from[n.id],W.lines.to[n.id]],df:t,seqCol:e,activityCol:l}),n.x,n.y)})),D.addProperty("similarityLimit","double",C),A=function(){const t=s.accordion(),e=s.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(s.span([e,s.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),r.shell.o=t.root,t}(),D}var ft,gt=n(2003),yt=n(3516),bt=n(6718),vt=n(3077),wt=n(439);!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(ft||(ft={}));var Ct=n(9192);class At{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class St extends k{constructor(t={}){super({...t,enableMCL:!0});const e=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new At}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const t=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(t){super.applyInput(t),this.activitiesInput.value=this.tableInput.value.col(t.activityCol),this.similarityInput.value=t.simThreshold}}var xt,Et,Tt,Mt=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function _t(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}function It(t,e){return`${e} (${t.length>4?`${t.length} columns`:t.map((t=>t.name)).join(", ")})`}n(5540),function(t){t.ADD="ADD",t.SUB="SUB",t.MULT="MULT"}(xt||(xt={})),function(t){t.SQUARE="SQUARE",t.INVERSE="INVERSE",t.TRANSPOSE="TRANSPOSE",t.NORM="NORM",t.COLUMN_NORM="COLUMN_NORM"}(Et||(Et={})),function(t){t.SCALARMULT="SCALARMULT",t.SCALARADD="SCALARADD",t.SCALARPOW="SCALARPOW"}(Tt||(Tt={})),Object.prototype.toString;var Lt=n(6873),Nt=n(4356),Pt=n(6717),$t=n(4870),Rt=n(3856),kt=n(6882),Ot=n(7278),Ht=n(5553),Gt=n(6642),Ft=n(3599),Dt=n(673),Bt=n(8312);class Vt extends Gt.sD{monomerLib=null;seqHelper=null;constructor(t,e){super(t,e,io.logger),(0,bt.pj)().then((t=>{this.monomerLib=t.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,Bt.Q)().then((t=>{this.seqHelper=t,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var Wt=n(4139);const Ut=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class jt extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(t){this.seqHandler.column.set(this.rowIdx,t)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===wt.YI.DNA}isRna(){return this.seqHandler.alphabet===wt.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===wt.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(t,e){if(null==e.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=e.column.dataFrame.cell(t,e.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=t,this.seqHandler=e}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const t=(0,Ot.qp)(this.helm),e=[],n=/\(|\)/;for(let i=0;i<t.length;i++){const o=t.getOriginal(i),r=o.split(n).filter((t=>!!t));3===r.length?(e.push(r[0]),e.push(r[1]),e.push(r[2])):e.push(o)}return new Ot.Mu(e,this.seqHandler.defaultGapOriginal)}}const qt=gt.zS;function zt(t){const e=!$().enumerate(t).some((([e,n])=>e.length>1&&0!=n&&n!=t.length-1)),n=[],i=e?"":" ";for(const[e,o]of $().enumerate(t)){let r=e;o<t.length&&(r+=`${e?"":"-"}${i}`),n.push(r)}return[n,e]}class Yt extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=io.seqHelper}getRendererBack(t){const[e,n,i]=(0,Gt.BG)(t);if(n.meta.units!==gt.Hi.CUSTOM)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(e,n)),o}onClick(t,e){if(t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate(),t.cell.column.meta.units===gt.Hi.CUSTOM){const n=this.getRendererBack(t);n?.onClick(t,e)}}onMouseEnter(t,e){const n=this.getRendererBack(t);n?.onMouseEnter(t,e),this.hasMouseOver=!0}onMouseMove(t,e){const n=this.getRendererBack(t);n?.onMouseMove(t,e)}onMouseLeave(t,e){if((0,Ht.WN)(t,null),t?.grid){const e=t.grid.onEvent("d4-grid-show-tooltip").subscribe((t=>{e.unsubscribe(),this.hasMouseOver&&t.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(t,e){const n=this.getRendererBack(t);n?.onDoubleClick(t,e)}onKeyDown(t,e){const n=this.getRendererBack(t);n?.onKeyDown(t,e)}onKeyPress(t,e){const n=this.getRendererBack(t);n?.onKeyPress(t,e)}renderInt(t,e,n,i,o,r,s){const[a,l,c]=(0,Gt.BG)(r);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(io.properties?io.properties.maxMonomerLength:4)??50;if(Rt.gp.maxMonomerLength in l.tags){const t=parseInt(l.getTag(Rt.gp.maxMonomerLength));d=!isNaN(t)&&t?t:50}if(".mm.cellRenderer.maxMonomerLength"in h){const t=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(t)&&t?t:50}let p=c.rendererBack;p||(p=c.rendererBack=new kt.Jy(a,l,io.logger,d,(()=>{const{font:t,fontWidth:e}=kt.Jy.getFontSettings(l);return{font:t,fontCharWidth:e,separatorWidth:u.isMsa()?8:0,monomerToShort:qt}})),l.temp[".mm.cellRenderer.settingsChanged"],Dt.s.true,p.init().then((()=>{}))),p.render(t,e,n,i,o,r,s)}render(t,e,n,i,o,r,s){if(r.cell.column?.meta?.units!==gt.Hi.CUSTOM)this.renderInt(t,e,n,i,o,r,s);else{const a=this.getRendererBack(r);a?.render(t,e,n,i,o,r,s)}}}class Kt extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",h=this.tableCol.tags[gt.gp.separator],u=this.tableCol.meta.units;i=(0,kt.U0)(l,t,e,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Ut.notationProvider]?.separatorSplitter??(0,Ot.Iv)(u,h),f=m(d),g=m(p),y=$().count(0).take(f.length).map((t=>f.getCanonical(t))).toArray(),b=$().count(0).take(g.length).map((t=>g.getCanonical(t))).toArray(),v=this.tableCol.getTag(gt.gp.alphabet);Xt(t,e,n,i,o,y,b,v===gt.YI.RNA||v===gt.YI.DNA?Ft.o.NUCLEOTIDE:Ft.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Gt.BG)(t);let o=i.rendererBack;return o||(o=i.rendererBack=new Kt(e,n)),o}}class Zt extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Wt.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,n,i,o,r,s){Kt.getOrCreate(r).render(t,e,n,i,o,r,s)}}function Xt(t,e,n,i,o,r,s,a,l,c,h){if(r.length!==s.length){const t=function(t,e){let n=0,i=0;const o=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)o[t]===r[t]&&n++;const s=o.length-r.length;for(let t=o.length-1;t>s;t--)o[t]===r[t-s]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill(wt.b9[gt.Hi.FASTA]);function l(t){return n>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l($()(e).toArray()):t=l($()(t).toArray()),{subParts1:t,subParts2:e}}(r,s);r=t.subParts1,s=t.subParts2}const u=t.measureText(zt(r).join("")),d=t.measureText(zt(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*r.length,t.canvas.width=p+4*r.length);let m=Math.max(e,e+(i-(p+4*r.length))/2)+5;const f=Math.max(n,n+(o-28)/2);t.save();try{t.beginPath(),t.rect(e,n,c?p+4*r.length:i,o),t.clip(),t.font="12px monospace",t.textBaseline="top";const u=7;for(let e=0;e<r.length;e++){const n=r[e],c=s[e];let d=kt.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=kt.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Rt.oZ)(t,n,m,f-u,i,o,{color:d,pivot:0,left:!0}),p=(0,Rt.oZ)(t,c,m,f+u,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),h&&(h[e]=Jt(n,c,d,r,f,u,o))}else m=(0,Rt.oZ)(t,n,m,f,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{t.restore()}}function Jt(t,e,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(zt([t]).join("")).width,h=l.measureText(zt([e]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,Rt.oZ)(l,t,0,o-r,u,s,{color:n,pivot:0,left:!0}),(0,Rt.oZ)(l,e,0,o+r,u,s,{color:i,pivot:0,left:!0}),a}var Qt,te=n(8070),ee=n(4326);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(Qt||(Qt={}));const ne=new class{constructor(){this.regionTypes=[Qt.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=ee.fH.Entropy,this.filterSource=ee.Fo.filterSource}};var ie=n(7602),oe=n(250);const re=Qt;var se,ae;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(se||(se={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight",t.filterSource="filterSource"}(ae||(ae={}));const le=ne;class ce extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ae.skipEmptyPositions,le.skipEmptyPositions,{category:se.DATA}),this.regionTypes=this.stringList(ae.regionTypes,le.regionTypes,{category:se.DATA,choices:Object.values(re).filter((t=>t!=re.Unknown))}),this.chains=this.stringList(ae.chains,le.chains,{category:se.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ae.fitWidth,le.fitWidth,{category:se.LAYOUT}),this.positionWidth=this.float(ae.positionWidth,le.positionWidth,{category:se.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ae.positionHeight,le.positionHeight,{category:se.LAYOUT,choices:Object.keys(ee.fH)}),this.filterSource=this.string(ae.filterSource,le.filterSource,{category:se.BEHAVIOR,choices:Object.values(ee.lT)}),this.viewSyncer=new ie.g(io.logger)}static viewerCounter=-1;viewerId=++ce.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const t=`${this.viewerToLog()}.detach()`,e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),e())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case ae.regionTypes:case ae.chains:this.setData(this.regions)}switch(t.name){case ae.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ae.fitWidth:case ae.positionWidth:this.calcSize();break;case ae.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ae.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t){const e=`${this.viewerToLog()}.setData()`;io.logger.debug(`${e}, in, regions.length = ${t.length}`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=t,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(t){io.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){io.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}', this.regions.length = ${this.regions.length}`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<n.length;t++)for(const o of this.chains){const r=e.find((e=>e.order==n[t]&&e.chain==o));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,o,e]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let t=0;t<n.length;++t)this.logos[t]={};for(const[t,e,n]of o)this.logos[t][e]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(ee.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),io.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){io.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let n=0;n<this.logos.length;n++){for(const e of this.chains)this.logos[n][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[n][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,n=13,i=9,o=(this.root.clientWidth-t-(this.logos.length-1)*i-n)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const n=this.logos[t][e];n.setOptions({[oe.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,e=this.filterSourceInput.value;this.viewSyncer.sync(`${t}`,(async()=>{if(this.filterSource!==e){this.props.getProperty(ae.filterSource).set(this,e);for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const n=this.chains[e];this.logos[t][n].setOptions({[oe.n5.filterSource]:this.filterSource})}}}))}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.viewerToLog()}.invalidate(${t?` <- ${t} `:""})`;this.viewSyncer.sync(`${e}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,te.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}var he=n(6625),ue=n(6863);async function de(t,e,n="Morgan",i=1,o=.6){const r=t.length,s=io.seqHelper.getSeqHandler(t),a=Array(r);let l=1;const c=new Map,h=t.categories,u=t.getRawData();for(let e=0;e<r;e++){if(null===h[u[e]]||t.isNone(e)){a[e]=null;continue}a[e]="";const n=s.getSplitted(e);for(let t=0;t<n.length;t++){const i=n.getCanonical(t);c.has(i)||(c.set(i,String.fromCharCode(l)),l++),a[e]+=c.get(i)}}let d={};if(e===ue.Z.MONOMER_CHEMICAL_DISTANCE||e===ue.Z.NEEDLEMANN_WUNSCH){const t=Array.from(c.keys()),r=await(0,bt.A7)(t,n),s={};Object.entries(r.alphabetIndexes).forEach((([t,e])=>{s[c.get(t)]=e}));const l=a.reduce(((t,e)=>Math.max(t,e?.length||0)),0);d={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:l},e===ue.Z.NEEDLEMANN_WUNSCH&&(d.gapOpen=i,d.gapExtend=o)}return{seqList:a,options:d}}var pe=n(4954);function me(t){const e=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.points.forEach((n=>{const i=s.divText(t.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),i]))})),e}function fe(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);t.points.forEach(((e,i)=>{n[i]=t.activityCol.get(e)}));const i={},o=io.seqHelper.getSeqHandler(t.seqCol),r=o.defaultBiotype,a=ye(o.getSplitted(t.points[0]),o.getSplitted(t.points[1]),r,i);return e.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),e.append(be(i)),e.append(ge("Activity delta",Math.abs(n[0]-n[1]))),e.append(ge("Cliff",t.sali)),e}function ge(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function ye(t,e,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=io.monomerLib;return Xt(r,0,0,0,30,$().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),$().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),n,s,!0,i),o}function be(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function ve(t,e){const n=a.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=t.col(e[0]).meta.units,n.setTag(gt.gp.separator,t.col(e[0]).getTag(gt.gp.separator)),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}class we extends a.JsViewer{constructor(t,e){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...e?{semType:e}:{},nullable:!1}),this.name=t,this.semType=e}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>{this.gridSelect||this.render(t)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("targetColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===this.semType&&(this.targetColumn=e)}this.debouncedRender()}}debouncedRender(t=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(t),this.debounceTimer=null}),100)}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class Ce extends we{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ue.Z.NEEDLEMANN_WUNSCH,ue.Z.HAMMING,ue.Z.LEVENSHTEIN,ue.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,gt.gp.aligned,gt.gp.separator,gt.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(t,e){super(t,e),this.distanceMetric=this.string("distanceMetric",ue.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const t=this.dataFrame.rowCount;this.preComputeDistanceMatrix=t<=1e4,this.requiresSampling=t>1e4}}needsGapPenalties(){return this.distanceMetric===ue.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ue.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ue.Z.NEEDLEMANN_WUNSCH}}const Ae={gapPenalty:1,matchScore:1,gapSymbol:wt.b9[wt.Hi.FASTA],localAlignment:!1};class Se extends Ce{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(t,e){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=e}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const e=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(t&&!this.gridSelect||e){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(t,this.idxs.length).init((t=>this.targetColumn?.get(this.idxs?.get(t)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.targetColumn.getTag(t))));const e=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;e.onCurrentRowChanged.subscribe((t=>{n&&clearTimeout(n),(e.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=e.col("indexes").get(e.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(e)}),300),this.gridSelect=!0)})),this.analysisGrid?(this.analysisGrid.dataFrame=e,this.analysisGrid.invalidate()):(this.analysisGrid=e.plot.grid(),(0,$t.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,$t.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const t=this.targetColumn.length,e=Math.min(this.limit,t-1);if(!this.knn||this.kPrevNeighbors!==e||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const t=this.distanceMetric,n=await de(this.targetColumn,t,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=e,this.knn=await(new B).getKNN(i,t,e,o)}const n=new Array(e).fill(0).map(((t,e)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][e],score:1-this.knn.knnDistances[this.targetMoleculeIdx][e]})));n.sort(((t,e)=>e.score-t.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",e+1).init((t=>n[t].idx)),this.scores=a.Column.float("score",e+1).init((t=>n[t].score))}createPropertyPanel(t){const e=s.div(),n={},i=this.molCol?.name,o=t.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(t.currentRowIdx),u=function(t,e,n={}){const i={...Ae,...n},o=t.length,r=e.length,s=Array(o+1).fill(0).map((()=>Array(r+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<o+1;n++)for(let o=1;o<r+1;o++)s[n][o]=Math.max(0,s[n-1][o-1]+(t.getCanonical(n-1)===e.getCanonical(o-1)?i.matchScore:-i.matchScore),s[n-1][o]-i.gapPenalty,s[n][o-1]-i.gapPenalty),s[n][o]>=a&&(a=s[n][o],l=[n,o]);let c=i.localAlignment?l[0]:o,h=i.localAlignment?l[1]:r,u=new Array(0),d=new Array(0);for(;c>0&&h>0;){const n=Math.max(s[c-1][h-1],s[c-1][h],s[c][h-1]);s[c][h]==s[c-1][h-1]+i.matchScore&&n==s[c-1][h-1]?(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1):s[c][h]==s[c-1][h]-i.gapPenalty?(d.push(i.gapSymbol),u.push(t.getCanonical(c-1)),c-=1):s[c][h]==s[c][h-1]-i.gapPenalty?(u.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1)}u=[...$().count(0).take(c).map((e=>t.getCanonical(e))),...u.reverse(),...i.localAlignment?$().count(l[0]).take(o).map((e=>t.getCanonical(e))):[]],d=[...$().count(0).take(h).map((t=>e.getCanonical(t))),...d.reverse(),...i.localAlignment?$().count(l[1]).take(r).map((t=>e.getCanonical(t))):[]];const p=c,m=h;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:u=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...u],d.length>u.length?u.push(...new Array(d.length-u.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(u.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:u.join(""),seq2:d.join(""),seq1Splitted:new Ot.Mu(u,i.gapSymbol),seq2Splitted:new Ot.Mu(d,i.gapSymbol)}}(c,h),d=ye(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);e.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&e.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(be(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>e),!0),r.shell.o=p.root}}class xe extends Ce{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;sampledIndices=null;constructor(t){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.targetColumn){await this.computeByMM();const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,e=a.Column.string(t,this.renderMolIds.length).init((t=>this.targetColumn?.get(this.renderMolIds[t])));e.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>e.setTag(t,this.targetColumn.getTag(t))));const n=a.DataFrame.fromColumns([e]);e.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]}));const i=n.plot.grid();(0,$t.Kd)(i,e.name,450,30),(0,$t.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const t=this.targetColumn.length;let e;this.requiresSampling&&t>1e4?(e=this.createRandomSample(t,1e4),this.sampledIndices=e):(e=Array.from({length:t},((t,e)=>e)),this.sampledIndices=null);const n=this.distanceMetric,i=await de(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=e.map((t=>o[t])),a=new D(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=e.length,h=(d=c,(t,e)=>d*t+e-Math.floor((t+2)*(t+1)/2)),u=function(t,e){function n(t,e){let n=null,i=null;for(const o of t){const t=e(o);(null==i||t>i)&&(n=o,i=t)}return n}const i=[(r=t-1,Math.floor(function(t){return Math.random()*t}(r)))],o=new Set;var r;for(let e=0;e<t;++e)i.includes(e)||o.add(e);for(;i.length<e;){const t=n(o.values(),(t=>Math.min.apply(Math,i.map((function(e,n){return l[h(t,e)]})))));null!=t&&(i.push(t),o.delete(t))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=u.map((t=>e[t]))}createRandomSample(t,e){const n=[];for(let e=0;e<t;e++)this.targetColumn.isNone(e)||n.push(e);if(n.length<=e)return n;for(let t=n.length-1;t>0;t--){const e=Math.floor(Math.random()*(t+1)),i=n[t];n[t]=n[e],n[e]=i}return n.slice(0,e)}}var Ee,Te=n(5433),Me=n(3890),_e=n(1687);!function(t){t.TYPE="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t[t.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",t.RGP_LINE_START="M  RGP",t.ATOM_ALIAS_LINE_START="A  ",t.END="M  END"}(Ee||(Ee={}));class Ie{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let n=t;const i=this.isWhitespace(n)?e:e-1;for(let t=0;t<i;t++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let n=this.getAtomBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToAtomType(n),e[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[t,e,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:t,y:e,z:n}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){e=this.shiftIdxToBondedAtomsPair(e);const i=new Uint16Array(2);i[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),i[1]=this.parseIntValue(e),t[n]=i,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let n=this.getBondBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToBondType(n),e[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let n=e+1;for(;!this.isWhitespace(n);)++n;return t(this.fileContent.substring(e,n))}}class Le extends Ie{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,n=e;return this.isQuote(e)?(n=this.getNextIdenticalChar(e),e++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(e,n)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((n=this.fileContent.charCodeAt(e+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<e;i++){if(n=this.shiftIdxToAtomType(n),t(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Ne extends Le{constructor(t){super(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map,e=this.fileContent.split("\n");e.filter((t=>t.startsWith(Ee.RGP_LINE_START))).forEach((e=>{const n=this.getAtomIdxToRgpIdxList(e);for(const[e,i]of n){if(t.has(e))throw new Error(`R group ${e} is already in the map`);t.set(e,i)}}));const n=e.map(((t,e)=>{if(t.startsWith(Ee.ATOM_ALIAS_LINE_START))return e})).filter((t=>void 0!==t)),i=n.map((t=>e[t])),o=n.map((t=>e[t+1]));i.forEach(((e,n)=>{const i=parseInt(e.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(t.has(r))throw new Error(`R group ${r} is already in the map`);t.set(r,i)}));const r=this.getRGroupAtomicIndices().filter((e=>!Array.from(t.values()).includes(e)));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return t}getAtomIdxToRgpIdxList(t){const e=t.split(/\s+/).filter((t=>t)).slice(3).map((t=>parseInt(t))),n=new Array(e.length/2);for(let t=0;t<e.length;t+=2)n[t/2]=[e[t+1],e[t]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((t,e)=>{if(t.includes("R#"))return e})).filter((t=>void 0!==t))}static isValidMolfile(t){return-1!==t.indexOf(Ee.TYPE)&&-1!==t.indexOf(Ee.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,Ee.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<Ee.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,Ee.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,Ee.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+Ee.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(t,e));return t=e,e+=Ee.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class Pe extends Le{constructor(t){super(t),this.init(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map;return this.getAtomLines().forEach(((e,n)=>{const i=e.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const e=i[1].split(/\s+/).map((t=>parseInt(t)));if(e.length>2)throw new Error(`R group data ${e} has more than 2 elements`);const o=e[1];if(t.has(o))throw new Error(`R group ${o} is already in the map`);t.set(o,n)}})),t}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M  V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M  END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M  V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const n=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class $e{constructor(){}static getInstance(t){if($e.isMolfileV2K(t))return new Ne(t);if($e.isMolfileV3K(t))return new Pe(t);throw new Error("Malformed molfile")}static isMolfileV2K(t){return Ne.isValidMolfile(t)}static isMolfileV3K(t){return Pe.isValidMolfile(t)}}var Re=n(6197),ke=n(9124),Oe=n(3527);class He{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(t,e,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=t,this.id=e,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++He.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ge extends He{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(t){super(t,"*","gap")}}class Fe extends He{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(t,e){super(t,e,"ambiguous")}}class De extends He{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(t,e,n){super(t,e,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Be extends He{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(t,e){super(t,e,"broken")}}class Ve{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(t,e,n,i,o,r,s,a){this.id=t,this.m=e,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(t,e,n){let i={};const o=e.symbol,r=e.smiles;if(e.rgroups.length>0)e.rgroups.forEach((t=>{i[t.label]=t.capGroupName}));else{if(!r){if(e.lib)return new Be(t,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Ve(e.symbol,e.molfile,e.name,e.naturalAnalog,e.polymerType,e.monomerType,i),a=n.getMonomerColors(t,e.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const We={[Ft.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ft.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ft.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Ft.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Ft.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Ft.o.CHEM]:{R:"#eeeeee"},[Ft.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},Ue=/[\w()]+/,je=RegExp(String.raw`\(${Ue}(,${Ue})+\)`),qe=t=>{const e=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,e,t),e},ze=new Oe.Mi([255,255,255]),Ye=new Oe.Mi([0,0,0]),Ke=.7*(0,K.wQ)(ze);class Ze{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(t,e){this._monomers=t,this.source=e,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([t,e])=>0===Object.keys(e).length));for(const[t,e]of Object.entries(this._monomers))for(const[t,n]of Object.entries(e))n.lib=this}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}addMissingMonomer(t,e){let n=this._monomers[t];n||(n=this._monomers[t]={});let i=e;return e==wt._S||e===wt.b9[wt.Hi.HELM]?i="Gap":("PEPTIDE"===t&&"X"===e||"RNA"===t&&"N"===e)&&(i="Any"),n[e]={symbol:e,name:i,molfile:"",author:"MISSING",id:-1,rgroups:$().count(1).take(9).map((t=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${t.toString()}`}))).toArray(),smiles:"",polymerType:t,monomerType:void 0,createDate:null}}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?e[n]:null}else{io.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}getWebEditorMonomer(t,e){const[n,i]=(0,ke.fA)(t,e),o=(0,Re.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Ft.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Ft.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===wt._S||"*"==i?s=r.wem=new Ge(n):n===Ft.o.NUCLEOTIDE&&"N"===i||n===Ft.o.AA&&"X"===i||(Ft.o.CHEM,0)||je.test(i)?s=r.wem=new Fe(n,i):r.lib||(s=r.wem=new De(n,i,this.isEmpty)),s||(s=r.wem=Ve.fromMonomer(n,r,this))),s}getTooltip(t,e){const n=(0,Re.Y)(t),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(t,e),r=this.getMonomer(n,e);if(r){const t=r.symbol,[e,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([t],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:e,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?qe(r.molfile):r.smiles?s.divV([qe(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=wt._S){let t=r.lib?.source;t?(t.endsWith(".json")&&(t=t.substring(0,t.length-5)),t=t.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(t))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${e}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(t,e){const n=this.getMonomerColors(t,e),i=t=>{const e=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(t);if(e)return[parseInt(e[1]),parseInt(e[2]),parseInt(e[3])];const n=a.Color.fromHtml(t);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new Oe.Mi([...o.map((t=>t+1))]),s=(0,K.KE)(r,ze)/((0,K.wQ)(r)*(0,K.wQ)(ze)),l=i(n.backgroundcolor),c=new Oe.Mi([...l.map((t=>t+.01))]);let h;h=(0,K.KE)(c,ze)/((0,K.wQ)(c)*(0,K.wQ)(ze))<s?l:o;let u=new Oe.Mi(h);const d=(0,K.wQ)(u);return d>Ke&&(u=(0,K.dC)(Ye,u,Ke/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(t,e){const n="default";let i=n;const o=(0,Re.Y)(t),r=this.getMonomer(o,e);let s;if(r){if(r.meta&&r.meta.colors){const t=r.meta.colors;n in t||(i="default"),s=t[i]}if(!s){const e=We[t],n=e?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const e=r.naturalAnalog;if(!s&&e)return this.getMonomerColors(t,e)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(t){const e=t.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(e)for(let t=0;t<e.length;t++)if(null!=e[t]&&/\d/.test(e[t])){i=e[t][e[t].length-1],e[t]=e[t].replace(/[0-9]/g,"");for(let n=0;n<e[t].length;n++)":"!=e[t][n]&&(o+=e[t][n]);n["R"+i]=o,o=""}return n}}var Xe=n(5488),Je={};Je.styleTagTransform=A(),Je.setAttributes=b(),Je.insert=g().bind(null,"head"),Je.domAPI=m(),Je.insertStyleElement=w(),d()(Xe.A,Je),Xe.A&&Xe.A.locals&&Xe.A.locals;class Qe extends Ze{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(t,e,n=void 0){super(t,e),this.error=n}toJSON(){const t=[];for(const e of Object.values(this._monomers))for(const n of Object.values(e))t.push({...n,lib:void 0,wem:void 0});return t}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?.[n]??null}else{io.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}_monomerSets=null;getMonomerSet(t){const e=(0,Re.Y)(t);if(this._monomerSets||(this._monomerSets={}),!(t in this._monomerSets))for(const[t,n]of Object.entries(this._monomers[e]));return this._monomerSets[t]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((n=>{e[n]=this._monomers[t][n].molfile})),e}getMonomerSymbolsByRGroup(t,e,n){let i=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return i=i.filter((t=>null!==t)),0===i.length?[]:(i=i.filter((e=>{if(!e?.rgroups)return!1;let n=e?.rgroups.length>=t;var i;return i=$e.getInstance(e.molfile).atomTypes,i.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),n&&=!0,n})),i.map((t=>t?.symbol)))}_updateLibInt(t){const e=t.getPolymerTypes(),n=this.getPolymerTypes();e.forEach((e=>{n.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((n=>{this._monomers[e][n]&&(this._duplicateMonomers[e]??={},this._duplicateMonomers[e][n]??=[this._monomers[e][n]],this._duplicateMonomers[e][n].push(t.getMonomer(e,n))),this._monomers[e][n]=t.getMonomer(e,n)}))})),this._isEmpty=this.isEmpty&&t.isEmpty}updateLibs(t,e=!1){e&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const e of t)e.error||this._updateLibInt(e);Object.entries(this.duplicateMonomers).length>0?(0,Nt.ub)().then((t=>{this.assignDuplicatePreferences(t)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(t){let e=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(t.duplicateMonomerPreferences?.[n]?.[i]){const o=t.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find((t=>t.lib?.source===o));r?this._monomers[n][i]=r:e=!1}else e=!1;return this._duplicatesHandled=e,e}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const t={},e=this.getPolymerTypes();for(const n of e)t[n]=this.getMonomerSymbolsByType(n).length;return t}getSummaryDf(){const t=this.getPolymerTypes(),e=new Array(t.length);for(const[n,i]of $().enumerate(t))e[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",t),a.Column.fromList(a.COLUMN_TYPE.INT,"count",e)])}getSummary(){const t=this.getPolymerTypes();return 0==t.length?"empty":t.map((t=>`${t} ${this.getMonomerSymbolsByType(t).length}`)).join("\n")}static overrideCounter=0;override(t,e){return new tn(t,`override: ${++Qe.overrideCounter}, ${e}`,this)}}class tn extends Ze{data;base;constructor(t,e,n){super(t,e),this.data=t,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(t){const e=this.base.getMonomerSymbolsByType(t);for(const n of Object.keys(this.data[t]??{}))e.includes(n)||e.push(n);return e}addMissingMonomer(t,e){return this.base.addMissingMonomer(t,e)}getMonomer(t,e){const n=this.data[t]?.[e];return n??this.base.getMonomer(t,e)}}class en{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(t,e,n,i,o){this.monomerLib=t,this.symbol=e,this.polymerType=n,this.monomerType=i,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map((t=>{const n=this.monomerLib.getMonomer(this.polymerType,t.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=t.source)throw new Error(`Monomer '${e}' found in different library.`);return n}))}catch(t){const[e,n]=(0,Ct.AP)(t);this.error=e,this.monomers=[]}}}class nn{description;placeholders;source;error;constructor(t,e,n=void 0,i=void 0){this.description=t,this.placeholders=e,this.source=n,this.error=i}updateSets(t,e=!1){e&&(this.placeholders=[]);for(const e of t)e.error||this._updateSetInt(e)}_updateSetInt(t){for(const e of t.placeholders)this.placeholders.push(e)}}var on=n(7433),rn=n.n(on),sn=n(1913),an=n.n(sn);class ln{helmMonomerSchema;validateMonomerSchema;constructor(t){this.helmMonomerSchema=t;const e=new(rn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});an()(e),this.validateMonomerSchema=e.compile(this.helmMonomerSchema)}validateFile(t,e){const n=this.parseJson(t,e);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,e):(console.warn(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(t,e){try{return JSON.parse(t)}catch(t){return console.error(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format:`,t),null}}validateJsonContent(t,e){let n=!0;const i=new Set;for(const o of t){const t=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${e} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${t}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}var cn=n(8604);class hn{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(t,e,n,i){let o;this.fileValidator=t,this.libHelper=e,this.eventManager=n,this.logger=i;let r=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((t=>o=t))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),r||(r=!0,o())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++hn.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(t,e,n){const i=await r.dapi.files.readAsText(cn.gt),o=JSON.parse(i),s=new ln(o);return new hn(s,t,e,n)}async addLibraryFile(t,e,n=!0){try{if(await r.dapi.files.exists(cn.so+`${e}`))return void r.shell.error(`File ${e} already exists`);await this.validateAgainstHELM(t,e),await r.dapi.files.writeAsText(cn.so+`${e}`,t),await this.updateValidLibList(),await r.dapi.files.exists(cn.so+`${e}`)?r.shell.info(`Added ${e} HELM library`):r.shell.error(`Failed to add ${e} library`)}catch(t){console.error(t),r.shell.error(`Failed to add ${e} library`)}}async deleteLibraryFile(t){try{await r.dapi.files.delete(cn.so+`${t}`),await this.updateValidLibList(),r.shell.info(`Deleted ${t} library`)}catch(e){console.error(e),await r.dapi.files.exists(cn.so+`${t}`)?r.shell.error(`Failed to delete ${t} library`):r.shell.warning(`File ${t} already deleted, refresh the list`)}}async loadLibraryFromFile(t,e){let n=[];const i=new a.FileSource(t),o=await i.readAsText(e);n=JSON.parse(o);const r={},s=[];return n.forEach((t=>{const e=t.polymerType,n=t.symbol;s.includes(e)||(r[e]={},s.push(e)),r[e][n]=t})),new Qe(r,e)}async loadSetFromFile(t,e,n){let i={};const o=new a.FileSource(e),r=await o.readAsText(n);i=JSON.parse(r);const s=i.description,l=Object.entries(i.placeholders).map((([e,n])=>{const i=e,o=n.polymerType,r=n.monomerType,s=n.set;return new en(t,i,o,r,s)}));return new nn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const t=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${t}, end, not changed`);for(const t of n){if(!t.endsWith(".json")){e.push(t);continue}const n=await r.dapi.files.readAsText(cn.so+`${t}`);this.isValidHELMLibrary(n,t)||e.push(t)}const i=n.filter((t=>!e.includes(t)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((t=>!t.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),e.length>0){const t=`Invalid monomer library files in ${cn.so}, consider fixing or removing them: ${e.join(", ")}`;this.logger.warning(t)}this.logger.debug(`${t}, OUT`)})),this.logger.debug(`${t}, end`),this.filesPromise}async updateValidSetList(){const t=`${this.toLog()}.updateValidSetList()`;return io.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{io.logger.debug(`${t}, IN`);const e=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void io.logger.debug(`${t}, end, not changed`);for(const t of n)t.endsWith(".json")?await r.dapi.files.readAsText(cn.Es+`${t}`):e.push(t);const i=n.filter((t=>!e.includes(t)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),io.logger.debug(`${t}, OUT`)})),io.logger.debug(`${t}, end`),this.filesPromise}libListHasChanged(t){const e=this.eventManager.getValidLibPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}setListHasChanged(t){const e=this.eventManager.getValidSetPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}async validateAgainstHELM(t,e){if(!this.isValidHELMLibrary(t,e))throw new Error(`File ${e} does not satisfy HELM standard`)}isValidHELMLibrary(t,e){return this.fileValidator.validateFile(t,e)}async getLibFileListAtLocation(){const t=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await r.dapi.files.list(cn.so).then((t=>t.filter((t=>t.isFile)).map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(cn.so.length)))}async getSetFileListAtLocation(){const t=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await r.dapi.files.list(cn.Es).then((t=>t.map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(cn.Es.length)))}}class un{constructor(){}static _instance;static getInstance(){return un._instance||(un._instance=new un),un._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((t=>{const e=this._libFilesUpdateSubject$.pipe((0,O.skip)(1)).subscribe((n=>{t(n),e.unsubscribe()}))}))}changeValidLibPathList(t){this._libFilesUpdateSubject$.next(t)}changeValidSetPathList(t){this._setFilesUpdateSubject$.next(t)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(t,e){this._librarySelectionSubject$.next([t,e])}}class dn{logger;_monomerLib=new Qe({},"MAIN");_monomerSets=new nn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(t=1/0){return t=t===1/0?6e4:t,await Promise.race([(async()=>{const t=await this.getFileManager();return await t.filesPromise,!0})(),(async()=>(await(0,te.cb)(t),!1))()]).then((e=>{if(!e)throw new Error(`Loading monomer libraries timeout ${t} ms.`)}))}constructor(t){this.logger=t}static objCounter=-1;objId=(()=>{if(++dn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return dn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(t){this._monomerLib.assignDuplicatePreferences(t)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const t=await hn.create(this,this._eventManager,this.logger);return await t.initializedPromise,t})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(t=!1){const e=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${e}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[e],i]=await Promise.all([await this.getFileManager().then((t=>[t.getValidLibraryPaths()])),(0,Nt.ub)()]),o=e.filter((t=>{const e=!i.exclude.includes(t),n=0===i.explicit.length||i.explicit.includes(t);return e&&n}));let r=0;const s=o.length,[a]=await Promise.all([Promise.all(o.map((t=>this.readLibrary(cn.so,t).catch((e=>{const n=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new Qe({},t,n)})).finally((()=>{n.update(Math.round(100*++r/s),`Loading monomers ${r}/${s}`)})))))]);this._monomerLib.updateLibs(a,t),this._initialLoadCompleted=!0}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;r.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{n.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadLibrariesPromise}async loadLibraries(t){return this.loadMonomerLib(t)}loadSetsPromise=Promise.resolve();async loadMonomerSets(t=!1){const e=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${e}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[e]]=await Promise.all([await this.getFileManager().then((t=>[t.getValidSetPaths()]))]),n=e.filter((t=>!0));let i=0;const o=n.length,[r]=await Promise.all([Promise.all(n.map((e=>this.readSet(cn.Es,e).catch((t=>{const n=`Loading monomer sets from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new nn("Broken monomer set",[],e,n)})).finally((()=>{t.update(Math.round(100*++i/o),`Loading monomers ${i}/${o}`)})))))]);this._monomerSets.updateSets(r)}catch(t){const e=`Loading monomer sets error: ${t instanceof Error?t.message:t.toString()}`;r.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{t.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadSetsPromise}async readLibrary(t,e){const n=await this.getFileManager();return await n.loadLibraryFromFile(t,e)}async readSet(t,e){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,t,e)}async selectSpecifiedLibraries(t){const e=await this.getInvalidFileNames(t);if(e.length>0)throw new Error(`Cannot select libraries ${e}: no such library in the list`);const n=await(0,Nt.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((e=>!t.includes(e))),await(0,Nt.Eu)(n)}async getInvalidFileNames(t){const e=(await this.getFileManager()).getValidLibraryPaths();return t.filter((t=>!e.includes(t)))}async loadMonomerLibForTests(){await(0,Nt.Eu)(cn.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let t=window.$monomerLibHelperPromise;return null==t&&(t=window.$monomerLibHelperPromise=(async()=>{const t=new dn(io.logger);return t._eventManager=un.getInstance(),t})()),t}}var pn=n(1757),mn=n.n(pn),fn=n(3017),gn={};gn.styleTagTransform=A(),gn.setAttributes=b(),gn.insert=g().bind(null,"head"),gn.domAPI=m(),gn.insertStyleElement=w(),d()(fn.A,gn),fn.A&&fn.A.locals&&fn.A.locals;var yn=n(3151);class bn{constructor(t,e=[],n={}){this.onItemChanged=new h.Subject,this.onAddingItemChanged=new h.Subject,this.onItemAdded=new h.Subject,this.onItemRemoved=new h.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=t,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=e,this.render()}get root(){return this._root}get items(){return this._items}set items(t){this._items=t,this.render()}addItem(t,e=!0){this._items.push(t),this.render(),e&&this.onItemAdded.next(t)}removeItem(t,e=!0){-1!==this._items.indexOf(t)&&(this._items.splice(this._items.indexOf(t),1),this.render(),e&&this.onItemRemoved.next(t))}removeAtIndex(t,e=!0){if(t<0||t>=this._items.length)return;const n=this._items.splice(t,1);this.render(),e&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var t,e,n,i,o;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(t=n.caption)&&void 0!==t?t:n.name;(null===(e=this.options.customLabels)||void 0===e?void 0:e[n.name])&&(i=this.options.customLabels[n.name]);const o=s.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const t of this._items){const e=this.getItemDiv(t);for(const t of e)this._root.appendChild(t)}if(this.options.allowAdd){const t=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const e of t)this._root.appendChild(e)}}get addingItem(){const t={};return Object.keys(this.addingItemInputs).forEach((e=>{t[e]=this.addingItemInputs[e].value})),t}getItemDiv(t={},e){var n,i;const o=[],r={};let l=null;for(const c of this.properties){void 0===t[c.name]&&(t[c.name]=null);const h=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](t):s.input.forProperty(c,t),u=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];u&&h.addValidator(u),o.push(this.options.horizontalInputNames?h.root:this.hideLabel(h.root)),c.propertyType!==a.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&h.input&&(h.input.style.width="100%"),r[c.name]=h,h.onChanged.subscribe((()=>{t[c.name]=h.value,e?this.onAddingItemChanged.next({item:t,fieldName:c.name}):this.onItemChanged.next({item:t,fieldName:c.name})})),h.root.style.alignItems="center",l=h}let c=null;if(e)this.addingItemInputs=r,c=s.icons.add((()=>{const t=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(r).forEach((e=>{t[e]=r[e].value})),this._items.push(t),this.onItemAdded.next(t),this.render()}),this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=s.icons.delete((()=>{this._items.splice(this._items.indexOf(t),1),this.onItemRemoved.next(t),this.render()}),this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(t){return t.getElementsByTagName("label")[0]&&t.removeChild(t.getElementsByTagName("label")[0]),t}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const vn={A:new U.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new U.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new U.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new U.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new U.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new U.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new U.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new U.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new U.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new U.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new U.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new U.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new U.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new U.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new U.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new U.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},wn={RNA:{A:new U.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new U.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new U.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new U.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new U.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:vn};async function Cn(t,e,n=0){if(!Object.keys(wn).includes(e))return null;const i=await async function(t){const e=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!e)return null;try{const n=(await e.apply({molString:t}))?.getBuffer().buffer;if(n)return new U.A(new Uint32Array(n),2048)}catch(t){return null}}(t);if(!i)return null;if(!wn[e])return null;const o=wn[e];let r=0,s=null;for(const[t,e]of Object.entries(o)){const o=(0,H.$1)(i,e);o>r&&o>=n&&(r=o,s=t)}return s}var An,Sn=n(857),xn={};xn.styleTagTransform=A(),xn.setAttributes=b(),xn.insert=g().bind(null,"head"),xn.domAPI=m(),xn.insertStyleElement=w(),d()(Sn.A,xn),Sn.A&&Sn.A.locals&&Sn.A.locals,function(t){t.MONOMER="Monomer",t.SYMBOL="Symbol",t.NAME="Name",t.R_GROUPS="~R-Groups",t.MONOMER_TYPE="Monomer Type",t.POLYMER_TYPE="Polymer Type",t.NATURAL_ANALOG="Natural Analog",t.AUTHOR="Author",t.CREATE_DATE="Create Date",t.ID="ID",t.META="Meta",t.SOURCE="Source"}(An||(An={}));const En={[An.MONOMER]:a.COLUMN_TYPE.STRING,[An.SYMBOL]:a.COLUMN_TYPE.STRING,[An.NAME]:a.COLUMN_TYPE.STRING,[An.R_GROUPS]:a.COLUMN_TYPE.STRING,[An.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[An.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[An.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[An.AUTHOR]:a.COLUMN_TYPE.STRING,[An.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[An.ID]:a.COLUMN_TYPE.INT,[An.META]:a.COLUMN_TYPE.STRING,[An.SOURCE]:a.COLUMN_TYPE.STRING};class Tn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(An.NAME).width=100,this.tv.grid.col(An.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=yn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(t){this.monomerLibManamger=t,this.monomerLib=t.getBioLib(),this._newMonomerForm=new Nn(t,(()=>this.activeMonomerLib),(async t=>{const e=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=e,this.adjustTable(),null!=t&&setTimeout((()=>{const n=e.col(An.SYMBOL).toList().indexOf(t);-1!==n&&(this.tv?.grid.scrollToCell(e.columns.byIndex(0),n),e.currentRow=e.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const t=await dn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.instance=new Tn(t)}return this.instance}static async getNewInstance(){const t=await dn.getInstance();return await t.awaitLoaded(),await t.loadLibrariesPromise,new Tn(t)}async createNewMonomerLib(t,e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(e.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);t.endsWith(".json")||(t+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,t),await r.dapi.files.writeAsText(cn.so+t,n),await this.monomerLibManamger.loadLibraries(!1),r.shell.v=await this.getViewRoot(t)}catch(t){r.shell.error("Error creating library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(t){const e=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const t=i(n.value);o.getButton("Create")?.classList?.toggle("d4-disabled",!!t)}});function i(t){return t&&t.trim()?t.endsWith(".json")&&e.includes(t)||e.includes(t+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const e=i(n.value);if(e)r.shell.warning(e);else{try{await this.createNewMonomerLib(function(){let t=n.value;return t.endsWith(".json")||(t+=".json"),t}(),t??[])}catch(t){r.shell.error("Error creating library"),console.error(t)}o.close()}})).show();o.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(t,e=!0){const n=await this.getMonomersDf(t);return this.tv=a.TableView.create(n,e),this.adjustTable(),this.tv.subs.push(r.events.onContextMenu.subscribe((({args:t})=>{if(!t||!t.menu||!t.context||t.context.type!==a.VIEWER.GRID||!t.context.tableView||t.context.tableView.id!==(this.tv.id??"")||!t.item||!t.item.isTableCell||(t.item.tableRowIndex??-1)<0)return;const e=t.item.tableRowIndex;t.menu.item("Edit Monomer",(async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(e))})),t.menu.item("Fix all monomers",(()=>{this.fixAllMonomers()})),this.tv.dataFrame.selection.trueCount>0?(t.menu.item("Remove Selected Monomers",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>On(this.tv.dataFrame.rows.get(t)))));this._newMonomerForm.removeMonomers(t,this.libInput.value)})),t.menu.item("Selection To New Library",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>On(this.tv.dataFrame.rows.get(t)))));this.createNewLibDialog(t)}))):t.menu.item("Remove Monomer",(async()=>{const t=await On(this.tv.dataFrame.rows.get(e));this._newMonomerForm.removeMonomers([t],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter((t=>t.name===Tn.VIEW_NAME)).forEach((t=>t.close()))}findActiveManagerView(){if(!this.tv)return null;const t=Array.from(r.shell.tableViews??[]).find((t=>t.id===this.tv.id));return t?r.shell.v=t:Tn.closeAllMonomerManagers(),t??null}_skipLibInputOnchange=!1;async getViewRoot(t,e=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),e&&(this.tv=this.findActiveManagerView())&&(t??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),t&&(this.libInput.value=t)}catch(t){r.shell.error("Error updating library list"),console.error(t)}finally{this._skipLibInputOnchange=!1}const e=await this.getMonomersDf(t);return this.tv.dataFrame=e,this.adjustTable(),this.tv}t??=n[0],this.tv=await this.getMonomersTableView(t,e);let i=this.tv.getRibbonPanels();i.forEach(((t,e)=>{i[e]=t.filter((t=>0!==t.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((t=>t.length>0));const o=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.iconFA("wand-magic",(()=>{this.fixAllMonomers()}),"Fix all monomers"),c=s.icons.edit((async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),h=s.icons.delete((async()=>{const t=this.tv?.dataFrame?.currentRowIdx??-1,e=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(t<0&&0===e.length)return;if(e.length>0){const t=await Promise.all(e.map((t=>On(this.tv.dataFrame.rows.get(t)))));return void await this._newMonomerForm.removeMonomers(t,this.libInput.value)}const n=await On(this.tv.dataFrame.rows.get(t));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(h,(()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer"));const u=s.iconFA("arrow-to-bottom",(async()=>{const t=this.libInput.value;if(!t)return r.shell.error("No library selected");let e=null;try{e=await r.dapi.files.readAsText(cn.so+t)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}if(!e)return r.shell.error(`Library ${t} is empty`);a.Utils.download(t,e,"text/plain")}),"Download Monomer Library");i.push([o,c,l,h,u]),this.tv.setRibbonPanels(i),this.tv.name=Tn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:t,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const t=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=t,this.adjustTable()}catch(t){console.error(t)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}async editMonomer(t){return this._newMonomer=await On(t),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(t??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(cn.so,t),!this.activeMonomerLib)return r.shell.error(`Library ${t} not found`),a.DataFrame.create();const e=this.activeMonomerLib.getPolymerTypes().flatMap((t=>this.activeMonomerLib.getMonomerSymbolsByType(t).map((e=>this.activeMonomerLib.getMonomer(t,e))))),n=a.DataFrame.create(e.length),i=new Set;for(const t of e)t.rgroups.forEach((t=>{t.label&&i.add(t.label)}));const o=Array.from(i);o.sort();for(const[t,e]of Object.entries(En))if(n.columns.addNew(t,e),t===An.R_GROUPS)for(const t of o)n.columns.addNew(t,a.COLUMN_TYPE.STRING);n.col(An.SYMBOL).semType="Monomer",n.col(An.SYMBOL).setTag(Rt.Mn.applyToBackground,"true");for(let t=0;t<e.length;t++){let i=$n(e[t].rgroups,e[t].smiles,e[t].molfile);i=Mn(i),e[t].rgroups=Ln(e[t].rgroups);const r=o.map((n=>{const i=e[t].rgroups.find((t=>t.label===n));return i?In(i,"capGroupSmiles"):""}));let s=null;if(e[t].createDate)try{s=Date.parse(e[t].createDate)}catch(n){console.error(`Error parsing date ${e[t].createDate}`)}n.rows.setValues(t,[i,e[t].symbol,e[t].name,JSON.stringify(e[t].rgroups??[]),...r,e[t].monomerType,e[t].polymerType,e[t].naturalAnalog,e[t].author,s,e[t].id,JSON.stringify(e[t].meta??{}),e[t].lib?.source??""]);try{s&&n.col(An.CREATE_DATE)?.set(t,s,!1)}catch(n){console.error(`Error setting date ${e[t].createDate}`)}}return n.col(An.MONOMER).semType=a.SEMTYPE.MOLECULE,o.forEach((t=>{n.col(t).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((async t=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;await this.editMonomer(n.rows.get(n.currentRowIdx))}catch(t){console.error(t)}})),n}catch(t){throw r.shell.error("Error creating monomers dataframe"),console.error(t),t}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK((async()=>{const t=this.tv?.dataFrame;let e=this.libInput.value;if(t&&e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await Promise.all(new Array(t.rowCount).fill(0).map(((e,n)=>On(t.rows.get(n))))),i=JSON.stringify(n.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);e.endsWith(".json")||(e+=".json"),await r.dapi.files.writeAsText(cn.so+e,i),await this.monomerLibManamger.loadLibraries(!0),r.shell.v=await this.getViewRoot(e)}catch(t){r.shell.error("Error saving library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")})).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function Mn(t){let e=t.replaceAll(/\[R[1-9]\]/g,(t=>`[*:${t[2]}]`));return e=e.replaceAll(/\[\d\*\]/g,(t=>`[*:${t[1]}]`)),e.replaceAll(/\[\d\*\:\d\]/g,(t=>`[*:${t[1]}]`))}const _n=["alternateId","capGroupName","capGroupSMILES","label"];function In(t,e){const n=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));if(n)return t[n]}function Ln(t){return t.map((t=>{const e=function(t,e){const n={};return t.forEach((t=>{const i=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));i&&(n[t]=e[i])})),n}(_n,t),n=In(e,"capGroupSMILES"),i=In(e,"alternateId"),o=In(e,"capGroupName"),r=In(e,"label")??"R1";if(n&&i&&o||r.length<2)return e;if(i&&-1!==i.indexOf(`${r}-`)){const t=i.replace(`${r}-`,"");o||(e.capGroupName=t),n||(e.capGroupSMILES=`[*:${r.substring(1)}][${t}]`)}else o&&(n||(e.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(e.alternateId=`${r}-${o}`));return e})).sort(((t,e)=>t.label?.localeCompare(e.label??"")??0))}class Nn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(t){this._molChanged=t}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(t,e,n,i){this.monomerLibManager=t,this.getMonomerLib=e,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Hn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const t=this.validateInputs();t?r.shell.warning(t):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));t&&t.header.style.removeProperty("background-color");let e=this.molSketcher.getSmiles();if(!e)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();e=$n([],e);const n=this.findRgroupsInSmiles(e);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((t=>t[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((t=>Number.parseInt(t[0].match(/[1-9]/g)[0]))).map((t=>this.rgroupsGrid.items.find((e=>e.label===`R${t}`))??{capGroupSMILES:`[*:${t}][H]`,alternateId:`R${t}-H`,capGroupName:"H",label:`R${t}`}));this.rgroupsGrid.items=i.sort(((t,e)=>t.label?.localeCompare(e.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Cn(kn(e,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(t){console.error(t)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new bn(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:t=>t?r.chem.checkSmiles(t)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:t=>t?null:"Alternate ID is required",capGroupName:t=>t?null:"Cap group name is required",label:t=>t?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new bn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const t=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=t?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(t){this.triggerMolChange=!1,this.molSketcher.setSmiles(t.smiles),this.polymerTypeInput.value=t.polymerType,this.monomerTypeInput.value=t.monomerType,this.monomerSymbolInput.value=t.symbol,this.monomerNameInput.value=t.name,this.monomerIdInput.value=t.id,this.monomerNaturalAnalogInput.value=t.naturalAnalog??null,this.rgroupsGrid.items=Ln(t.rgroups),this.metaGrid.items=Object.entries(t.meta??{}).filter((([t,e])=>"colors"!==t?.toLowerCase())).map((([t,e])=>({Property:t,Value:e}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!t.naturalAnalog&&t.polymerType&&Cn(kn(t.smiles,this.rgroupsGrid.items),t.polymerType).then((t=>{t&&(this.monomerNaturalAnalogInput.value=t)}));const e=t.meta?.colors??"";let n={};try{n=e?JSON.parse(e)?.default:{}}catch(t){console.error(t)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));if(t&&t.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const t of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==t.value||""===t.value)return`${t.caption} field is required`;let e=null;if(this.rgroupsGrid.items.length<1&&(e="At least one R-group is required"),!e)t:for(const t of this.rgroupsGrid.items)for(const[n,i]of Object.entries(t))if(!i){e=`R-group ${n} field is required for ${t.label}`;break t}return!e&&this.rgroupsGrid.hasErrors()&&(e="R-group fields contain errors"),e?(t&&t.header.style.setProperty("background-color","#ff000030"),e):null}findRgroupsInSmiles(t){return[...Array.from(t.matchAll(/\[[1-9]\*\]/g)),...Array.from(t.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const t=s.buttonsInput([this.saveButton]);return s.tooltip.bind(t,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,t],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(t){const e=$n(t.rgroups,t.smiles,t.molfile),n=r.chem.drawMolecule(e,150,150),i=s.tableFromMap({name:t.name,author:t.author,createDate:t.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(t,e,n=!0){let i=[];try{const t=await r.dapi.files.readAsText(cn.so+e);i=JSON.parse(t)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}const o=t.map((t=>Pn(i,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType))));for(let n=0;n<o.length;n++)if(-1===o[n])return void r.shell.error(`Monomer ${t[n].symbol} not found in library ${e}`);const a=o.map((t=>i[t])),l=s.divV(a.map((t=>this.getMonomerInfoTable(t))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map((t=>t.symbol)).join(", ")} from ${e} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${e} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",(async()=>{i=i.filter((t=>!a.includes(t))),await r.dapi.files.writeAsText(cn.so+e,JSON.stringify(i,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${c?"s":""} ${a.map((t=>t.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${e} library`),u.close()})).show()}async addMonomerToLib(t,e){let n=[];try{const t=await r.dapi.files.readAsText(cn.so+e);n=JSON.parse(t)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}const i=Pn(n,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType)),o=this.getMonomersDataFrame()?.col(An.MONOMER)?.toList()?.findIndex((e=>e===t.smiles)),a=async()=>{try{const i=n.findIndex((e=>e.symbol===t.symbol&&e.polymerType===t.polymerType));i>=0?n[i]={...t,lib:void 0,wem:void 0}:n.push({...t,lib:void 0,wem:void 0}),await r.dapi.files.writeAsText(cn.so+e,JSON.stringify(n,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(t.symbol),this._molChanged=!1,r.shell.info(`Monomer ${t.symbol} was successfully saved in library ${e}`)}catch(t){r.shell.error("Error saving monomer"),console.error(t)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${t.symbol}' already exists in library ${e}.\nAre you sure you want to overwrite it?`;else if((o??-1)>=0){const t=await On(this.getMonomersDataFrame().rows.get(o));l=this.getMonomerInfoTable(t),c=`Monomer with the same structure already exists in library ${e} with different symbol (${t.symbol}).\nAre you sure you want to duplicate it?`}if(l){const t=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{t.close(),a()})).show()}else await a()}async saveMonomer(){let t=this.molSketcher.getSmiles();if(!t||!r.chem.checkSmiles(t))return void r.shell.warning("Invalid SMILES");t=$n([],t);let e=r.chem.convert(t,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);e=Rn(e);const n={};this.metaGrid.items.filter((t=>!!t.Property&&!!t.Value)).forEach((t=>{n[t.Property]=t.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:e,smiles:t,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function Pn(t,e){let n=-1;for(let i=t.length-1;i>=0;i--)if(e(t[i])){n=i;break}return n}function $n(t,e,n){const i=!e||!r.chem.checkSmiles(e);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):e;return o=function(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=new RegExp(`\\[\\${t.capGroupName}:${e}\\]`,"g");n=n.replace(i,`[*:${e}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(t=>`[*:${t[1]}]`)),n}(o,t),o=Mn(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function Rn(t){const e=t.split("\n"),n=e.findIndex((t=>t.startsWith("M")&&t.includes("ISO")));if(-1!==n){const t=e[n].indexOf("ISO");e[n]=e[n].substring(0,t)+"RGP"+e[n].substring(t+3)}const i=e.findIndex((t=>t.includes("V2000")));if(-1===i)return console.error("Mol start line not found"),t;const o=Number.parseInt(e[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let t=i+1;t<i+1+o;t++){const n=e[t].indexOf("R ");if(-1===n)continue;"#"!==e[t][n+1]&&(e[t]=e[t].replace("R ","R#"));const o=e[t].trim().split(" ").map((t=>t.trim())).filter(Boolean);if(r[t-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[t-i]=s)}const s=Object.keys(r);if(-1===e.findIndex((t=>t.startsWith("M")&&t.includes("RGP")))){const t=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map((([t,e])=>`${t.toString().padStart(4," ")}${e.toString().padStart(4," ")}`)).join("")}`,n=e.findIndex((t=>t.startsWith("M")&&t.includes("END")));e.splice(n,0,t)}return s.filter((t=>!!Number.parseInt(t))).map((t=>Number.parseInt(t)+i)).forEach((t=>{const n=e[t].split(" "),i=n.findIndex((t=>"R#"===t));if(-1!==i){for(let t=i+1;t<n.length;t++)n[t]&&1==n[t].length&&(Number.parseInt(n[t])??0)>0&&(n[t]="0");e[t]=n.join(" ")}})),e.join("\n")}function kn(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=In(t,"capGroupName");n=n.replace(`[*:${e}]`,`[${i}]`)})),n}async function On(t){let e;try{e=JSON.parse(t.get(An.META)??"{}");for(const t in e)"object"==typeof e[t]&&(e[t]=JSON.stringify(e[t])),("string"!=typeof e[t]||e[t]!==a.INT_NULL.toString()&&e[t]!==a.FLOAT_NULL.toString())&&("number"!=typeof e[t]||e[t]!==a.INT_NULL&&e[t]!==a.FLOAT_NULL)||(e[t]=null)}catch(t){console.error(t)}const n=t.get(An.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=Rn(i)}catch(t){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(t)}let o=t.get(An.NATURAL_ANALOG);const s=t.get(An.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(t.get(An.R_GROUPS)??"[]"),!o&&s){const t=await Cn(kn(n,l),s);t&&(o=t)}}catch(t){l??=[]}return{symbol:t.get(An.SYMBOL),name:t.get(An.NAME),molfile:i,smiles:n,polymerType:s,monomerType:t.get(An.MONOMER_TYPE),naturalAnalog:o,id:t.get(An.ID),rgroups:l,meta:e,author:t.get(An.AUTHOR),createDate:t.get(An.CREATE_DATE)}}class Hn{_colors;_colorInputs;constructor(t){this._colors=t,this._colorInputs={line:s.input.color("Line",{value:t.line,onValueChanged:t=>this._colors.line=t}),background:s.input.color("Background",{value:t.background,onValueChanged:t=>this._colors.background=t}),text:s.input.color("Text",{value:t.text,onValueChanged:t=>this._colors.text=t})}}get colors(){return this._colors}set colors(t){const e={line:a.Color.toHtml(a.Color.fromHtml(t.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(t.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(t.text??"#000000"))};this._colors=e;for(const t in this._colorInputs)this._colorInputs[t].value=e[t]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(t){this._selected=t,this.root.style.border=t?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(t){this.monomer=t}render(){s.empty(this.root);const t=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(t);const e=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(e),s.tooltip.bind(e,this.monomer.name),this.monomer.lib?.source){const t=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(t),s.tooltip.bind(t,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Fn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(t,e,n,i){this.monomerSymbol=t,this.monomers=e,this.monomerCards=e.map((t=>new Gn(t)));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(t,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,t),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach((t=>{t.root.onclick=()=>{this.monomerCards.forEach((t=>t.selected=!1)),t.selected=!0,i(t.monomer)},n&&t.monomer===n&&(t.selected=!0),o.appendChild(t.root)}))}render(){this.monomerCards.forEach((t=>t.render()))}}class Dn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Dn._instance||(Dn._instance=new Dn,await Dn._instance.refresh(),(await dn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Dn._instance.refresh()))),Dn._instance.refresh(),Dn._instance}async refresh(){this.settings=await(0,Nt.ub)();const t=await dn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.monomers=t.duplicateMonomers,this.monomerCardRows=[];for(const e in this.monomers)for(const n in this.monomers[e]){const i=this.settings.duplicateMonomerPreferences?.[e]?.[n]??null,o=i?this.monomers[e][n].find((t=>t.lib?.source===i))??null:null;this.monomerCardRows.push(new Fn(n,this.monomers[e][n],o,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][n]=i.lib.source,await(0,Nt.Eu)(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),t.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(t=>(this.monomerCardRows[t].render(),this.monomerCardRows[t].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>t(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const t=t=>{this.filteredMonomerRows=this.monomerCardRows.filter((e=>e.monomerSymbol.toLowerCase().includes(t.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)))}}}constructor(){}get root(){return this._root}}async function Bn(){await jn.showDialog()}async function Vn(t=!0){return await qn.showView(t)}class Wn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Wn.instancePromise&&(Wn.instancePromise=(async()=>{const t=new Wn,e=await(0,bt.pj)();return t._fileManager=await e.getFileManager(),t._widget=await t.createWidget(),t})()),Wn.instancePromise}static async reloadWidget(){const t=await Wn.getInstance();t._widget=await t.createWidget()}async createWidget(){const t=await this.getWidgetContent();return(await(0,bt.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(t)}async getWidgetContent(){const t=await Un.createControlsForm();return mn()(t).addClass("monomer-lib-controls-form"),setTimeout((()=>{t&&mn()(t)&&mn()(t).removeClass("ui-form-condensed")}),200),s.divV([t])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async t=>{const e=await t.text(),n=t.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(e,n)}catch(t){r.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Un{fileManager;userLibSettings;constructor(t,e){this.fileManager=t,this.userLibSettings=e,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([t,e])=>{this.updateLibrarySelectionStatus(e,t)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){io.logger.debug("LibraryControlsForm.createControlsForm(), start");const[t,e]=await Promise.all([(0,bt.pj)().then((t=>t.getFileManager())),await(0,Nt.ub)()]);return new Un(t,e)._createControlsForm()}_createControlsForm(){const t=this.createLibraryControls(),e=s.wideForm(t,void 0);return mn()(e).addClass("monomer-lib-controls-form"),e}updateControlsForm(){const t=this._createControlsForm();mn()(".monomer-lib-controls-form").replaceWith(t)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((t=>this.createLibInput(t)))}createLibInput(t){const e=`${this.toLog()}.createLibInput()`;io.logger.debug(`${e}, libFileName = '${t}', start`);const n=!this.userLibSettings.exclude.includes(t),i=s.input.bool(t,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(t,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${t}`);const o=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(t))),a=s.icons.edit((async()=>{r.shell.v=await(await Tn.getInstance()).getViewRoot(t)}),"Edit monomer library");return s.tooltip.bind(o,`Delete ${t}`),i.addOptions(a),i.addOptions(o),io.logger.debug(`${e}, libFileName = '${t}', end`),i}async updateLibrarySelectionStatus(t,e){this.updateLibrarySettings(t,e),await(0,Nt.Eu)(this.userLibSettings);const n=await(0,bt.pj)();await n.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved")}updateLibrarySettings(t,e){t?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((t=>t!==e)):this.userLibSettings.exclude.includes(e)||this.userLibSettings.exclude.push(e)}promptForLibraryDeletion(t){s.dialog("Warning").add(s.divText(`Delete file ${t}?`)).onOK((async()=>{try{const e=a.TaskBarProgressIndicator.create(`Deleting ${t} library`);await this.updateLibrarySelectionStatus(!1,t),await this.fileManager.deleteLibraryFile(t),e.close()}catch(e){console.error(e),r.shell.error(`Failed to delete ${t} library`)}})).showModal(!1)}}class jn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){jn._instance||(jn._instance=new jn,jn._instance.closeDialogSubject$.subscribe((()=>{jn._instance.dialog=void 0}))),jn._instance.dialog||(jn._instance.dialog=await jn._instance.getDialog()),jn._instance.dialog.show()}async getDialog(){const t=un.getInstance(),e=(await Wn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});mn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>t.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class qn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(t=!0){const e=un.getInstance(),n=(await Wn.getInstance()).widget,i=s.bigButton("Add",(()=>e.addLibraryFile()),"Upload new HELM monomer library"),o=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,o])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach((t=>t.unsubscribe())),this._view.detach(),this._view.close()}catch(t){}return this._view=a.View.fromRoot(l),this._view.name=qn.viewName,t&&r.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const t=Array.from(l.children).filter((t=>t.classList.contains("ui-box")));if(2!==t.length)return;const[e,n]=t,i=e.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;e.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`}),100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe((()=>{try{const t=qn._instance;t&&t._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===t._view.id&&t._duplicateManager?.refresh()}catch(t){console.error(t)}})))})),this._view}static async showView(t=!0){return qn._instance||(qn._instance=new qn),qn._instance._duplicateManager||(qn._instance._duplicateManager=await Dn.getInstance()),qn._instance.libManager||(qn._instance.libManager=await dn.getInstance()),t&&qn._instance._view&&Array.from(r.shell.views).find((t=>t.id&&t.id===qn._instance._view.id))?(r.shell.v=qn._instance._view,await qn._instance._duplicateManager.refresh(),qn._instance._view):(qn.closeExistingViews(),qn._instance.getView(t))}static closeExistingViews(){Array.from(r.shell.views).filter((t=>t.name===qn.viewName)).forEach((t=>t.close()))}async mergeSelectedLibs(){const t="Library with this name already exists",e=await dn.getInstance();if(await e.awaitLoaded(),await e.loadLibrariesPromise,!e.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=e.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const e=h(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!e&&e!==t),i.getButton("Save")?.classList?.toggle("d4-disabled",!!e)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let t=o.value;return t.endsWith(".json")||(t+=".json"),t}function h(e){return e&&e.trim()?e.endsWith(".json")&&l.includes(e)||l.includes(e+".json")?t:null:"Library name cannot be empty"}o.addValidator(h),i.add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const t=c(),e=JSON.stringify(n),o=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await o.addLibraryFile(e,t,!1);const n=await(0,Nt.ub)();n.exclude=l,await(0,Nt.Eu)(n),await this.libManager.loadLibraries(!0),await Wn.reloadWidget()}catch(e){r.shell.error(`Failed to save library ${t}. see console for details.`),console.error(e)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var zn,Yn=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};class Kn{_setBreadcrumbsInViewName(){var t,e;const n=["Home","Demo",...(null!==(t=this._path)&&void 0!==t?t:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((t=>Yn(this,void 0,void 0,(function*(){const e=t[t.length-1];if(e===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===e?n:n.items.find((t=>t.text===e))})))),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const t=s.iconFA("home",(()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));t.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(t)}const t=null===(e=r.shell.v.ribbonMenu.root.parentElement)||void 0===e?void 0:e.getElementsByClassName("d4-ribbon-name")[0];t&&(t.textContent="",t.appendChild(i.root))}}constructor(t,e,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>Yn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,Kn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),o=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var t;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(t=this._path)&&void 0!==t?t:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Yn(this,void 0,void 0,(function*(){var t,e;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(t){console.error(t)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,te.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Yn(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return Yn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),t.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){return Yn(this,void 0,void 0,(function*(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return Yn(this,void 0,void 0,(function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Kn.currentObject=null}step(t,e,n){return this._steps[this.steps.length]={name:t,func:e,options:n},this}start(){return Yn(this,void 0,void 0,(function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Kn.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(zn||(zn={}));var Zn=n(966),Xn=n(608),Jn=n(1619);class Qn{urlParams;funcName;options;df;view;constructor(t,e,n={}){this.urlParams=t,this.funcName=e,this.options=n}async init(t){this.df=t,await this.buildView()}async buildView(){const t=$()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${io.name}.${this.funcName}?${t}`;const e={...this.options,sequenceColumnName:"sequence"};for(const[t,n]of this.urlParams.entries())switch(t){case oe.n5.fixWidth:case oe.n5.fitArea:e[t]=["1","on","true"].includes(n.toLowerCase());break;default:e[t]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ti{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const t=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:t,filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ei=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ni="-";class ii extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,o,r,s){t.save(),t.beginPath(),t.rect(e,n,i,o),t.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Rt.Mn.applyToBackground);t.font="12px monospace",t.textBaseline="middle",t.textAlign="left";let a=r.cell.value;a&&a!==wt._S||(a=ni);const l=a.split(wt.ot).map((t=>t&&t!==wt._S?t.trim():ni)),c=l.map((t=>(0,gt.zS)(t,Math.max(2,Math.floor(.15*i/l.length))))),h=c.map((e=>t.measureText(e).width)),u=h.reduce(((t,e)=>t+e),0);let d=e+(i-u)/2;const p=this.tableCol.getTag(wt.gp.alphabet),m=p===gt.YI.RNA||p===gt.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA;for(let r=0;r<c.length;r++){const a=l[r];let u=kt.S$,p="rgb(255, 255, 255)";if(this.monomerLib)if(s){const t=this.monomerLib.getMonomerColors(m,a);u=t?.textcolor??u,p=t?.backgroundcolor??p}else u=this.monomerLib.getMonomerTextColor(m,a);s&&1==l.length&&(t.fillStyle=p,t.fillRect(e,n,i,o)),t.fillStyle=u,t.fillText(c[r],d,n+o/2,i),d+=h[r]}}finally{t.restore()}}onMouseMove(t,e){if(t.grid.dart!=this.gridCol?.grid.dart||t.gridColumn.dart!=this.gridCol?.dart||!t.tableColumn||!t.isTableCell)return!1;const n=t.tableColumn.getTag(wt.gp.alphabet),i=t.cell.value,o=t.grid.canvas.getBoundingClientRect(),r=t.bounds.right+o.left-4,a=t.bounds.bottom+o.top-4;if(!i||i==wt._S||i==ni)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===gt.YI.RNA||n===gt.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA,c=i.split(wt.ot).map((t=>t&&t!==wt._S&&t!==ni?this.monomerLib.getTooltip(l,t):s.divText("gap"))),h=s.divH(c,{style:{alignItems:"top"}}),u=Array.from(h.querySelectorAll("canvas"));if(u.length>2){const t=Math.floor(550/u.length);u.forEach((e=>{e.style.setProperty("max-width",`${t}px`,"important"),e.style.setProperty("max-height",`${t}px`,"important")}))}return s.tooltip.show(h,r,a),!0}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Gt.BG)(t);let o=i.rendererBack;return o||(o=i.rendererBack=new ii(e,n)),o}}class oi extends a.GridCellRenderer{get name(){return Wt.uF.MONOMER}get cellType(){return Wt.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,n,i,o,r,s){ii.getOrCreate(r).render(t,e,n,i,o,r,s)}onMouseMove(t,e){ii.getOrCreate(t).onMouseMove(t,e)}}class ri{constructor(t,e,n=""){this.target=t,this.debugEnabled=e,this.prefix=n}error(t,e,n){return this.target.error(this.prefix+t,e,n)}warning(t,e){return this.target.warning(this.prefix+t,e)}info(t,e){return this.target.info(this.prefix+t,e)}debug(t,e){if(this.debugEnabled)return this.target.debug(this.prefix+t,e)}}class si extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const t=super.get("FontSize");return t&&!isNaN(t)?Number.parseInt(t):12}set fontSize(t){super.set("FontSize",t),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const t=super.get("MaxMonomerLength");return"long"===t?null:parseInt(t)}set maxMonomerLength(t){const e=null===t?"long":t.toString();super.set("MaxMonomerLength",e),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t))}}class ai extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(t){this._properties=t}_initialized=!1;get initialized(){return this._initialized}constructor(t={debug:!1}){super(),super._logger=new ri(super.logger,t.debug)}completeInit(t,e,n,i){this._seqHelper=t,this._monomerLib=e,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(t){const[e,n]=(0,Ct.AP)(t);r.shell.error(e),this.logger.error(e,void 0,n)}}var li=n(5999),ci={};ci.styleTagTransform=A(),ci.setAttributes=b(),ci.insert=g().bind(null,"head"),ci.domAPI=m(),ci.insertStyleElement=w(),d()(li.A,ci),li.A&&li.A.locals&&li.A.locals;var hi=n(6307);class ui extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(t,e){super(s.divV([])),this.seqCol=t,this.seqHelper=e}async init(){const t=this.seqHelper.getSeqHandler(this.seqCol),e=io.properties.tooltipWebLogo,n=this.seqCol.getTag(ee.gp.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function di(t,e,n,i){const o=io.seqHelper.getSeqHandler(t);let r=null,s=null;for(let t=0;t<o.posList.length;++t)o.posList[t]==e&&(r=t),o.posList[t]==n&&(s=t);if(null===r&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${t.name}: (${e??""}-${n??""})`;return o.getRegion(r,s,a)}const pi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(gt.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class mi{urlParams;funcName;view;data;constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??pi;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(gt.gp.positionNames,this.data.positionNames),this.data.regions&&e.setTag(gt.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${io.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class fi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(t,e){this.call=t,this.seqHelper=e;const n=t=>this.call.inputParams[t].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const t in this.call.inputParams)s.tooltip.bind(this.inputs[t].captionLabel,n(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&this.seqHelper.getSeqHandler(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?this.seqHelper.getSeqHandler(t):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),o=document.createElement("option");e.text=o.text=t,e.value=o.value=t,n.options.add(e),i.options.add(o)}n.value=e?.posList[0]??"",i.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(gt.gp.regions):null,n=e?JSON.parse(e):null,i=this.inputs.region.input;for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const t of n){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),i.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let i=t.options.length-1;i>=0;--i){const o=t.options[i],r=JSON.parse(o.value);r&&e===r.start&&n===r.end&&(t.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=e?`${n.name}(${e.name}): ${e.start}-${e.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(t).onOK((()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{io.handleErrorUI(t)}))})).show()}widget(){const t=s.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=s.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{io.handleErrorUI(t)}))}));return a.Widget.fromRoot(s.divV([t,s.div(e)]))}}var gi=n(8754);async function yi(t,e,n,i,o){const r=await async function(t,e,n,i,o){const r=(0,vt.R)(e,o),s=o.getSeqHandler(e).getNewColumnFromList("ref",[n]),l=o.getSeqHandler(s).getSplitted(0),c=i===ft.IDENTITY?function(t,e){const n=e.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=e.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<t.length?t.getOriginal(s):wt._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",e.rowCount),l=s.getRawData();for(let n=0;n<e.rowCount;++n){l[n]=0;for(let e=0;e<t.length;++e)(i[e]?i[e][n]:0)===r[e]&&++l[n];l[n]/=t.length}return s}(l,r):i===ft.SIMILARITY?await async function(t,e,n){const i=e.columns.toList();return await(0,bt.uL)(i,t,n)}(l,r,o):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=t.columns.getUnusedName(c.name),t.columns.add(c),c}(t,e,n,i,o);for(let t=0;t<r.length;t++)e.isNone(t)&&r.set(t,null,!1);return r}var bi=n(294),vi=n(330);const wi=OCL;var Ci=n(9099);class Ai{monomerSymbol;constructor(t){this.monomerSymbol=t}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const t=this.rGroups.getAtomicIdx(1);if(null===t)return;const{x:e,y:n}=this.atoms.atomCoordinates[t];this.atoms.shift({x:-e,y:-n})}alignR2AlongX(){const t=this.rGroups.getAtomicIdx(2);if(null===t)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const e=this.atoms.atomCoordinates[t],n=e.y/e.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(t){this.rGroups.deleteBondLineWithSpecifiedRGroup(t)}shiftCoordinates(t){this.atoms.shift(t)}rotateCoordinates(t){this.atoms.rotate(t)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(t){this.rGroups.removeRGroups(t)}replaceRGroupWithAttachmentAtom(t,e){this.rGroups.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.rGroups.getAttachmentAtomIdByRGroupId(t)}shiftBonds(t){this.bonds.shift(t)}capRGroups(t){this.rGroups.capRGroups(t)}}var Si=n(6956);class xi{atoms;bonds;constructor(t,e,n){this.atoms=e,this.bonds=n,this.rGroupIdToAtomicIndexMap=t.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(t){const e=this.rGroupIdToAtomicIndexMap.get(t);return void 0===e?null:e}removeRGroupsFromAtomBlock(t){t.forEach((t=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(t))throw new Error(`Cannot find atomic index for R group ${t}`)}));const e=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([e,n])=>t.includes(e))).map((([t,e])=>e));this.atoms.deleteAtoms(e)}removeRGroups(t){this.removeRGroupsFromAtomBlock(t),t.forEach((t=>{const e=this.replaceRGroupInBondsByDummy(t);this.rGroupBondPositionMap.set(t,e)}))}replaceRGroupInBondsByDummy(t){const e=this.rGroupIdToAtomicIndexMap.get(t);if(this.rGroupBondPositionMap.has(t))throw new Error(`R group ${t} is already handled`);const n=this.bonds.getPositionsInBonds(e+1);if(0===n.length)throw new Error(`Cannot find position for R group ${t}`);if(n.length>1)throw new Error(`More than one position for R group ${t}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(e+1),this.removeRGroupFromAtomicIdxMap(t,e),i}removeRGroupFromAtomicIdxMap(t,e){this.rGroupIdToAtomicIndexMap.delete(t);for(const[t,n]of this.rGroupIdToAtomicIndexMap)n>e&&this.rGroupIdToAtomicIndexMap.set(t,n-1)}deleteBondLineWithSpecifiedRGroup(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n}=e;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(t),this.rGroupIdToAtomicIndexMap.delete(t),this.rGroupBondPositionMap.forEach((t=>{t.bondLineIdx>n&&(t.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(t,e){const n=this.rGroupBondPositionMap.get(t);if(!n)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=e}getAttachmentAtomIdByRGroupId(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n,nodeIdx:i}=e;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(t){this.rGroupIdToAtomicIndexMap.forEach(((e,n)=>{const i=t[n-1];i===Si.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(e,i)}))}}class Ei{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(t,e){this.rawAtomLines[t]=this.rawAtomLines[t].replace("R#",e)}deleteAtoms(t){this.coordinates=this.coordinates.filter(((e,n)=>!t.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((e,n)=>!t.includes(n)))}shift(t){this.coordinates=this.coordinates.map((e=>{const n=e.x+t.x,i=e.y+t.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${t.x}, ${t.y}`);return{x:n,y:i}}))}rotate(t){this.coordinates=this.coordinates.map((e=>{const n=e.x,i=e.y,o=n*Math.cos(t)-i*Math.sin(t),r=n*Math.sin(t)+i*Math.cos(t);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${t}`);return{x:o,y:r}}))}}class Ti extends Ei{constructor(t){super(),this.rawAtomLines=t.getAtomLines(),this.coordinates=this.rawAtomLines.map((t=>({x:parseFloat(t.substring(0,10)),y:parseFloat(t.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((t,e)=>{const n=this.coordinates[e];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${t.substring(20)}`}))}}class Mi{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(t){this.rawBondLines=this.rawBondLines.filter(((e,n)=>!t.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((e,n)=>!t.includes(n)))}getPositionsInBonds(t){const e=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,o)=>{n===t&&e.push({bondLineIdx:i,nodeIdx:o})}))})),e}replacePositionsInBondsByDummy(t,e){void 0===e&&(e=-1),t.forEach((t=>{const{bondLineIdx:n,nodeIdx:i}=t;this.bondedAtomPairs[n][i]=e}))}removeAtomIdFromBonds(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e>t?e-1:e))))}shift(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e+t))))}}class _i extends Mi{constructor(t){super(),this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((t=>[parseInt(t.substring(0,3)),parseInt(t.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((t,e)=>{if(t.some((t=>-1===t)))throw new Error(`Bonded pair ${t} contains -1`);return`${t[0].toString().padStart(3," ")}${t[1].toString().padStart(3," ")}${this.rawBondLines[e].substring(6)}`}))}}class Ii extends Ai{constructor(t,e){super(e);const n=$e.getInstance(t);this.atoms=new Ti(n),this.bonds=new _i(n),this.rGroups=new xi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Li extends Ei{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawAtomLines=t.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const t=this.molfileHandler.x,e=this.molfileHandler.y;return Array.from(t).map(((t,n)=>({x:t,y:e[n]})))}get atomLines(){const t=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,e=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(t,((t,e,n,i,o,a)=>e+r+i+s+a)).replace(e,"")}))}replaceRGroupSymbolByElement(t,e){super.replaceRGroupSymbolByElement(t,e);const n=this.rawAtomLines[t].substring(3).split(" ");n.length>7&&(this.rawAtomLines[t]=`M  ${n.slice(0,7).join(" ")}`)}}class Ni extends Mi{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((t=>[t[0],t[1]]))}getBondLines(){const t=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((e,n)=>{if(e.some((t=>-1===t)))throw new Error(`Bonded pair ${e} contains -1`);return this.rawBondLines[n].replace(t,((t,n,i,o,r,s)=>`${n}${e[0]}${o}${e[1]}${s}`))}))}}class Pi extends Ai{constructor(t,e){super(e);const n=$e.getInstance(t);this.atoms=new Li(n),this.bonds=new Ni(n),this.rGroups=new xi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class $i{static getInstance(t,e){if($e.isMolfileV2K(t))return new Ii(t,e);if($e.isMolfileV3K(t))return new Pi(t,e);throw new Error("Unsupported molfile version")}}class Ri{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(t,e,n,i,o,r){this.monomerSymbol=t,this.monomerIdx=e,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;$e.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,t,o)),this.molfileWrapper=$i.getInstance(a,t),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[e]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(t,e,n){if(Ri.molfileV2KToV3KCache.has(t))return Ri.molfileV2KToV3KCache.get(t);let i=null;try{if(i=n.get_mol(t,JSON.stringify({mergeQueryHs:!0})),i){const e=i.get_v3Kmolblock();return Ri.molfileV2KToV3KCache.set(t,e),e}throw new Error(`Cannot convert ${e} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const t=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),e=this.monomerLib.getMonomer(t,this.monomerSymbol);if(!e)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return e}getCapGroupElements(t){return t.rgroups.map((t=>(t.capGroupSmiles||t.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(t){this.molfileWrapper.shiftCoordinates(t)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(t){this.molfileWrapper.removeRGroups(t)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(t,e){this.molfileWrapper.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.molfileWrapper.getAttachmentAtomByRGroupId(t)}deleteBondLineWithSpecifiedRGroup(t){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(t)}shiftBonds(t){this.molfileWrapper.shiftBonds(t)}}class ki{rdKitModule;monomerLib;constructor(t,e,n){this.rdKitModule=e,this.monomerLib=n,this.helm=new Ci.f(t)}monomerWrappers=[];helm;addMonomer(t,e,n){if(t===wt.b9[gt.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Ri(t,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const t=[];let e=0;return this.monomerWrappers.forEach((n=>{t.push(e),e+=n.getAtomLines().length})),t}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((t=>{const e=t.map((t=>t.monomerIdx)),n=t.map((t=>t.rGroupId)),i=e.map((t=>this.monomerWrappers[t])),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const t=[],e=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((t,e)=>{t.shiftBonds(n[e])})),this.restoreBondsBetweenMonomers();const i=new bi.Cg;for(const[n,o]of $().enumerate(this.monomerWrappers)){const r=t.length,s=e.length;t.push(...n.getAtomLines()),e.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Ft.o.NUCLEOTIDE:Ft.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:$().count(r).take(n.atomCount).toArray(),bonds:$().count(s).take(n.bondCount).toArray()})}const o=t.length,r=e.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(t),this.getV3KBondBlock(e),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(t,e){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${t} ${e} 0 0 1`}getV3KAtomBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,o)=>e+i+o))})),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,o)=>e+i+o))})),"M  V30 END BOND"].join("\n")}}class Oi{constructor(t){this.molfileHandler=$e.getInstance(t)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(t){return{x:this.molfileHandler.x[t],y:this.molfileHandler.y[t]}}}class Hi{helmHelper;rdKitModule;monomerLib;constructor(t,e,n){this.helmHelper=t,this.rdKitModule=e,this.monomerLib=n}convertToSmiles(t){const e=t.dataFrame,n=this.getSmilesList(t),i=`smiles(${t.name})`,o=e?e.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map((t=>null===t?"":t)))}getSmilesList(t){return this.convertToMolfileV3KColumn(t).toList().map((t=>a.chem.convert(t,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(t){try{if(!t)return"";return wi.Molecule.fromMolfile(t).toMolfileV3().replace("STERAC1","STEABS")}catch(t){const[e,n]=(0,Ct.AP)(t);return io.logger.error(e,void 0,n),""}}getMolV3000ViaOCL(t,e){const n=t.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let t=0;t<n.length;t++){i[t]=this.molV3KtoMolV3KOCL(n[t]);const e=t/n.length*100;o.update(e,`${e?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(e,i)}convertToRdKitBeautifiedMolfileColumn(t,e,n,i){const o=t.dataFrame,r=this.convertToMolfileV3KColumn(t).toList().map((t=>{if(""===t)return null;const e=n.get_mol(t);return e?(e.set_new_coords(),e.normalize_depiction(1),e.straighten_depiction(!0),e):null})),s=`molfile(${t.name})`,l=o?o.columns.getUnusedName(s):s;return e?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})))}convertToMolfileV3KColumn(t){const e=t.dataFrame,n=this.convertToMolfileV3K(t.toList()).map((t=>t.molfile)),i=(0,vi.kA)(e,`molfileV3K(${t.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(t){const e=new Array(t.length);for(let n=0;n<t.length;++n){const i=t[n];if(!i){e[n]=bi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(t){const[e,n]=(0,Ct.AP)(t);io.logger.error(e,void 0,n),o=bi.vF.createEmpty()}e[n]=o}return e}getPolymerGraphColumn(t){const e=t.toList(),n=this.helmHelper.getMolfiles(e);return a.Column.fromStrings("mols",n)}getPolymerMolfile(t){const e=this.helmHelper.removeGaps(t),n=e.resHelm,i=new Map;for(const[t,n]of e.monomerMap?.entries()??[])i.set(n,t);const o=this.helmHelper.getMolfiles([n])[0],r=new Oi(o),s=new ki(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach(((t,e)=>{const n=r.getMonomerShifts(e);s.addMonomer(t,e,n)}));const a=s.compileToMolfile(),l=new bi.Cg;for(const[t,e]of a.monomers.entries()){const n=i.get(t);l.set(n,e)}return new bi.vF(a.molfile,l)}}class Gi{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(t,e){if(this.seqHelper=e,t.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${a.TYPE.STRING}'.`);this._column=t;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ut.notationProvider]??null);const i=this.isFasta()?wt.b9[gt.Hi.FASTA]:this.isSeparator()?wt.b9[gt.Hi.SEPARATOR]:this.isHelm()?wt.b9[gt.Hi.HELM]:this.isCustom()?this.notationProvider?.defaultGapOriginal??wt.b9[gt.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(gt.gp.aligned)||!this.column.tags.has(gt.gp.alphabet)||!this.column.tags.has(gt.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===gt.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag(gt.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,e)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(gt.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(gt.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${gt.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||this.isCustom()&&this.notationProvider||t.temp.seqHandlerRefined||(this.refineSeparatorNotation(),t.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const t=((t,e,n)=>{const i={};let o=!0,r=null;for(const e of t){const t=e?n(e):[];if(null===r?r=t.length:t.length!==r&&(o=!1),t.length>=3)for(const e of t)e in i||(i[e]=0),i[e]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?$().count(0).take(Math.min(100,this.column.length)).map((t=>this.column.get(t))):this.column.categories.slice(0,100)).map((t=>t?t.substring(0,500):"")).filter((t=>0!==t.length)))],0,(t=>t.split(this.separator)));let e=!1;const n=[{package:"SequenceTranslator",name:"refineNotationProviderForHarmonizedSequence"}];for(const i of n)try{const n=a.Func.find(i);if(0===n.length)continue;const o=n[0].prepare({col:this.column,stats:t,separator:this.separator}),r=(await o.call()).getOutputParamValue();e||=r}catch(t){console.error(t)}e&&(delete this.column.temp[Ut.seqHandler],this.column.fireValuesChanged())}static setTags(t){const e=t.column.meta.units;if([gt.Hi.FASTA,gt.Hi.SEPARATOR].includes(e)){if(!t.column.getTag(gt.gp.alphabet)&&0===Object.keys(t.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let e=t.column.getTag(gt.gp.aligned);null===e&&(e=t.stats.sameLength?"SEQ.MSA":"SEQ",t.column.setTag(gt.gp.aligned,e));let n=t.column.getTag(gt.gp.alphabet);if(null===n&&(n=(0,Ot.pc)(t.stats.freq,gt.q7),t.column.setTag(gt.gp.alphabet,n)),n===gt.YI.UN){const e=Object.keys(t.stats.freq).length,n=Object.keys(t.stats.freq).some((t=>t.length>1));t.column.setTag(gt.gp.alphabetSize,e.toString()),t.column.setTag(gt.gp.alphabetIsMultichar,n?"true":"false")}}else if(e===gt.Hi.HELM){let e=t.column.getTag(gt.gp.alphabet);null===e&&(e=(0,Ot.p0)(t.stats.freq,gt.q7,t.defaultGapOriginal),t.column.setTag(gt.gp.alphabet,e))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const t=this.column.getTag(gt.gp.separator)??void 0;if(this.notation===gt.Hi.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag(gt.gp.aligned);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag(gt.gp.alphabet);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get defaultBiotype(){return this.alphabet===gt.YI.RNA||this.alphabet===gt.YI.DNA?Ft.o.NUCLEOTIDE:Ft.o.AA}get helmCompatible(){return this.column.getTag(gt.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==gt.Hi.HELM||this.alphabet==gt.YI.UN){const t=this.column.getTag(gt.gp.alphabetSize);let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case gt.YI.PT:return 20;case gt.YI.DNA:case gt.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===gt.Hi.HELM||this.alphabet===gt.YI.UN&&"true"===this.column.getTag(gt.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(t,e){if(this.cached&&void 0===e){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let e=this._splitted[t]?this._splitted[t].deref():void 0;if(!e){const n=this.column.get(t);e=this.splitter(n),this._splitted[t]=new WeakRef(e)}return e}{const n=this.column.get(t);return this.getSplitter(e)(n)}}getMonomerAtPosition(t,e,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(t)??"")[e];return n?i===wt.b9[gt.Hi.FASTA]?wt._S:i??wt._S:i??""}const i=this.getSplitted(t);return e<0||e>=i.length?this.defaultGapOriginal:n?i.getCanonical(e):i.getOriginal(e)}getMonomersAtPosition(t,e){const n=this.column.length,i=new Array(n).fill(wt._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(t<n.length){const o=n[t];i[s]=e?o===wt.b9[gt.Hi.FASTA]?wt._S:o??wt._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);t>=0&&t<n.length&&(i[o]=e?n.getCanonical(t):n.getOriginal(t))}return i}getValue(t,e){return this.column.get(t),new jt(t,this)}getHelm(t){let e;const n=this.column.get(t);return e=this.notation===gt.Hi.HELM?n:this.notation===gt.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(gt.Hi.HELM)(n),e}_stats=null;get isCanonicalAlphabet(){const t=this.alphabet;return t===gt.YI.DNA||t===gt.YI.RNA||t===gt.YI.PT}get stats(){if(null===this._stats){const t={};let e=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(e=!1);for(let e=0;e<i.length;++e){const n=i.getCanonical(e);n in t||(t[n]=0),t[n]+=1}}this._stats={freq:t,sameLength:e}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:$().count(0).take(this.column.length).map((t=>this.getSplitted(t).length)).reduce(((t,e)=>t>e?t:e),0)),this._maxLength}_posList=null;get posList(){if(null===this._posList){const t=this.column.getTag(gt.gp.positionNames);this._posList=t?t.split(gt.z1).map((t=>t.trim())):$().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===gt.Hi.FASTA}isSeparator(){return this.notation===gt.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===gt.Hi.HELM}isCustom(){return this.notation===gt.Hi.CUSTOM}isRna(){return this.alphabet===gt.YI.RNA}isDna(){return this.alphabet===gt.YI.DNA}isPeptide(){return this.alphabet===gt.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||t===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return gt.Hi.FASTA;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return gt.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.Hi.HELM;if(this.units.toLowerCase().startsWith(gt.Hi.CUSTOM))return gt.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(t,e,n,i){const o=this.column,r=t.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=t,t===gt.Hi.SEPARATOR){if(!e)throw new Error(`Notation '${gt.Hi.SEPARATOR}' requires separator value.`);l.setTag(gt.gp.separator,e)}l.setTag(a.TAGS.CELL_RENDERER,t===gt.Hi.HELM?"helm":"sequence");const c=o.getTag(gt.gp.aligned);c&&l.setTag(gt.gp.aligned,c);let h=o.getTag(gt.gp.alphabet);h||this.notation!==gt.Hi.HELM||t===gt.Hi.HELM||(h=gt.YI.UN),null!=h&&l.setTag(gt.gp.alphabet,h);let u=o.getTag(gt.gp.alphabetSize);null!=h&&u&&l.setTag(gt.gp.alphabetSize,u);const d=o.getTag(gt.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(gt.gp.alphabetIsMultichar,d),t==gt.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(gt.gp.alphabetSize,u)),l}getNewColumnFromList(t,e){return this.getNewColumn(this.notation,this.separator,t,e)}static unitsStringIsValid(t){return t=t.toLowerCase(),[gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!Gi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",e,new Array(t).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(t){let e=null;if(e=this.notationProvider?this.notationProvider.splitter:null,e)return e;if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return null===this.column.getTag(gt.gp.alphabet)||this.getAlphabetIsMultichar()?gt.J9:Ot.tm;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return(0,gt.dh)(this.separator,t);if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.qp;throw new Error(`Unexpected units ${this.units} .`)}split(t){return this.splitter(t)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ue.Z.HAMMING;switch(this.alphabet){case gt.YI.DNA:case gt.YI.RNA:case gt.YI.PT:}return ue.Z.LEVENSHTEIN}getDistanceFunction(){return ue.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(gt.gp.isHelmCompatible))return"true"===this.column.getTag(gt.gp.isHelmCompatible);const t=(await(0,bt.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),e=new Set(t),n=((0,gt.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let t=0;t<i;++t){const i=o[t];if(!(i in n)){n.add(i);const o=this.getSplitted(t);for(let t=0;t<o.length;++t){const n=o.getCanonical(t);if(!e.has(n))return this.column.setTag(gt.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(gt.gp.isHelmCompatible,"true"),!0}toFasta(t){return t===gt.Hi.FASTA}toSeparator(t){return t===gt.Hi.SEPARATOR}toHelm(t){return t===gt.Hi.HELM}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?wt.b9[gt.Hi.FASTA]:wt.b9[gt.Hi.SEPARATOR]),n||(n=this.toFasta(e)?"":this.separator);const o=t.startsWith("RNA"),r=(0,gt.qp)(t),s=[];for(let t=0;t<r.length;++t){let n=r.getOriginal(t);if(o&&(n=n.replace(yn.EK,"$1")),n===wt.b9[gt.Hi.HELM])s.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join(n)}convert(t,e){const n=this.getJoiner({notation:t,separator:e}),i=this.getNewColumn(t,e);return i.init((t=>{const e=this.getSplitted(t);return n(e)})),i}getRegion(t,e,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=t??0,r=e??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=wt.b9[this.notation];i.init((t=>{const e=this.getSplitted(t),n=new Array(a);for(let t=0;t<a;++t){const i=o+t;n[t]=i<e.length?e.getOriginal(i):l}return s(new Ot.Mu(n,l))}));const c=t=>{const e=t.split(",").map((t=>t.trim())),n=new Array(a);for(let t=0;t<a;++t){const i=o+t;n[t]=i<e.length?e[i]:"?"}return n.join(gt.z1)},h=this.column.getTag(gt.gp.positionNames);h&&i.setTag(gt.gp.positionNames,c(h));const u=this.column.getTag(gt.gp.positionLabels);return u&&i.setTag(gt.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(t){const e=t?t.notation:this.notation,n=t?t.separator:this.separator;let i;const o=this;switch(e){case gt.Hi.FASTA:i=function(t){return o.joinToFasta(t,o.isHelm())};break;case gt.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${e}'.`);i=function(t){return Fi(t,n,o.isHelm())};break;case gt.Hi.HELM:{const t=o.alphabet===gt.YI.DNA||o.alphabet===gt.YI.RNA,e=o.getHelmWrappers();i=function(n){return Di(n,e,t)};break}default:throw new Error(`Unexpected notation '${e}'.`)}return i}getConverter(t,e=void 0){if(t===gt.Hi.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${gt.Hi.SEPARATOR}'.`);const n=this;if(t===gt.Hi.FASTA)return function(t){return n.convertToFasta(t)};if(t===gt.Hi.HELM)return function(t){return n.convertToHelm(t)};if(t===gt.Hi.SEPARATOR)return function(t){return n.convertToSeparator(t,e)};throw new Error}static forColumn(t,e){let n=t.temp[Ut.seqHandler];return n&&n.columnVersion===t.version||(n=t.temp[Ut.seqHandler]=new Gi(t,e)),n}joinToFasta(t,e){const n=new Array(t.length);for(let i=0;i<t.length;++i){const o=t.getOriginal(i);let r=t.getOriginal(i);e&&(r=r.replace(yn.EK,"$1")),o===wt._S?r=wt.b9[gt.Hi.FASTA]:o===yn.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(t){const e=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(t):e(t);return this.joinToFasta(n,this.isHelm())}convertToSeparator(t,e){return Fi(this.isHelm()?this.splitterAsHelmNucl(t):this.splitter(t),e,this.isHelm())}convertToHelm(t){if(this.notation==gt.Hi.HELM)return t;const e=this.getHelmWrappers(),n=t.startsWith("DNA")||t.startsWith("RNA");return Di(this.splitter(t),e,n)}splitterAsHelmNucl(t){const e=this.splitter(t),n=new Array(e.length),i=t.startsWith("DNA"),o=t.startsWith("RNA");for(let t=0;t<e.length;++t){let r=e.getOriginal(t);(i||o)&&(r=r.replace(yn.EK,"$1"),r=r===yn.q7?null:r),n[t]=r||null}return new Ot.Mu(n.filter((t=>!!t)),wt.b9[gt.Hi.HELM])}getRendererBack(t,e){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(t,e)),i}}function Fi(t,e,n){const i=new Array(t.length);for(let e=0;e<t.length;++e){const o=t.getCanonical(e);let r=t.getOriginal(e);n&&(r=r.replace(yn.EK,"$1")),o===wt._S?r=wt.b9[gt.Hi.SEPARATOR]:o===yn.q7&&(r=""),i[e]=r}return i.join(e)}function Di(t,e,n){const[i,o,r,s]=e,a=new Array(t.length);for(let e=0;e<t.length;++e){const i=t.getCanonical(e);let s=t.getOriginal(e);i===wt._S?s=wt.b9[gt.Hi.HELM]:(n&&(s=s.replace(yn.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[e]=s}return`${i}${a.join(".")}${s}`}class Bi{libHelper;rdKitModule;constructor(t,e){this.libHelper=t,this.rdKitModule=e}getSeqHandler(t){return Gi.forColumn(t,this)}getSeqMonomers(t){const e=this.getSeqHandler(t);return Object.keys(e.stats.freq)}async getHelmToMolfileConverter(t){const e=await(0,ke.b2)();return new Hi(e,this.rdKitModule,t)}helmToAtomicLevelSingle(t,e,n,i=!0){if(!t)return bi.vF.createEmpty();const o=e.convertToMolfileV3K([t])[0];if(!o||!o.molfile)return bi.vF.createEmpty();let r=null;try{let t=o.molfile;if(i){if(r=this.rdKitModule.get_mol(t),!r)return bi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),t=r.get_v3Kmolblock()}return n&&(t=e.molV3KtoMolV3KOCL(t)),new bi.vF(t,o.monomers)}catch(t){const[e,n]=(0,Ct.AP)(t);return io.logger.error(e,void 0,n),bi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(t,e,n,i){const o=i??this.libHelper.getMonomerLib(),s=t.dataFrame,l=(0,vi.qj)(s,t.name),c=await this.getHelmToMolfileConverter(o),h=t.toList(),u=new Array(t.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<t.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,e&&!p,!d).molfile;if(d){const e=await d.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n])}if(e&&p){const e=await p.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",t.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.FASTA)throw new Error(`The column of notation '${gt.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);t.column.meta.units=gt.Hi.FASTA,Gi.setTags(t)}setUnitsToSeparatorColumn(t,e){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.SEPARATOR)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must have the separator tag.`);t.column.meta.units=gt.Hi.SEPARATOR,t.column.setTag(gt.gp.separator,e),Gi.setTags(t)}setUnitsToHelmColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${gt.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);t.column.meta.units=gt.Hi.HELM,Gi.setTags(t)}}async function Vi(t){let e="";try{if(!t||!t.value)return e="No sequence provided",{errorText:e,mol:""};if(!(t.cell&&t.cell.dart&&t.cell.dataFrame&&t.cell.column))return e="Atomic level conversion requeires a sequence column",{errorText:e,mol:""};if(![gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].includes(t.cell.column.meta.units?.toLowerCase()??""))return e="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:e,mol:""};const n=(await Tr()).getSeqHandler(t.cell.column);if(!n)return e="No sequence handler found",{errorText:e,mol:""};if((n.getSplitted(t.cell.rowIndex,50)?.length??100)>40)return e="Maximum number of monomers is 40",{errorText:e,mol:""};const i=a.Column.fromStrings("singleVal",[t.value]),o=a.DataFrame.fromColumns([i]);if(Object.entries(t.cell.column.tags).forEach((([t,e])=>{i.setTag(t,e)})),await $o(o,i,t.cell.column.meta.units===gt.Hi.HELM,!1),o.columns.length<2)return e="No structure generated",{errorText:e,mol:""};const r=o.columns.byIndex(1).get(0);return r?{errorText:"",mol:r}:(e="No structure generated",{errorText:e,mol:""})}catch(t){io.logger.error(t)}return e="No Structure generated",{errorText:e,mol:""}}const Wi="#333333",Ui="rgba(60, 177, 115, 0.1)",ji="rgba(240, 240, 240, 0.5)",qi="rgba(100, 100, 100, 0.3)";class zi{constructor(t=Zi.DEFAULT_TRACK_HEIGHT,e=Zi.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=t,this.defaultHeight=t,this.minHeight=e,this.title=n}init(t){this.ctx=t}getMonomerAt(t,e,n){return null}enableTooltip(t){this.tooltipEnabled=t}setTooltipContentGenerator(t){this.tooltipContent=t}getTooltipContent(t,e){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(t)??new Map;return this.tooltipContent(t,e,n)}getPositionData(t){return null}setVisible(t){this.visible=t}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(t){this.height=Math.max(this.minHeight,t)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(t){this.title=t}getTitle(){return this.title}}class Yi extends zi{constructor(t=new Map,e=Zi.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(e,Zi.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=t,this.visible=t.size>0}setHovered(t,e){this.hoveredPosition=t,this.hoveredMonomer=e}getPositionData(t){return this.data.get(t)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator(((t,e,n)=>this.createTooltipContent(t,e,n)))}createFrequencyTable(t){let e;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":e=Ft.o.NUCLEOTIDE;break;default:e=Ft.o.AA}const n=Array.from(t.values()).reduce(((t,e)=>t+e),0),i={};for(const[e,o]of t.entries())i[e]=Math.max(1,Math.round(o/n*100));const o=(0,hi.F)(i,e,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(t,e,n){const i=[];if(i.push(s.divText(`Position: ${t+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),e&&(i.push(s.divText(`Monomer: ${e}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(e)&&i.push(s.divText(`${(100*n.get(e)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const t=this.createFrequencyTable(n);i.push(t)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(t){this.monomerLib=t}setBiotype(t){this.biotype=t}getMonomerAt(t,e,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=e,r=Array.from(i.entries()).sort(((t,e)=>e[1]-t[1])),s=r.reduce(((t,[e,n])=>t+n),0),a=this.height;let l=0;for(const[t,e]of r){const n=e*a/s;if(o>=l&&o<l+n)return t;l+=n}return null}updateData(t){this.data=t,this.visible=t.size>0}draw(t,e,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,h=e+2;for(let u=0;u<l;u++)this.drawWebLogoColumn(u,t,e,n,i,o,r,s,a,h,c)}drawWebLogoColumn(t,e,n,i,o,r,s,a,l,c,h){const u=r+t-1;if(u<0||u>=a)return;const d=this.data.get(u);if(!d||0===d.size)return;const p=e+t*s,m=s-2;r+t===l&&(this.ctx.fillStyle=Ui,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=ji,this.ctx.fillRect(p+1,c,m,h),this.drawLettersInColumn(u,p,m,c,h,d),this.drawColumnBorder(p,c,m,h)}drawLettersInColumn(t,e,n,i,o,r){const s=Array.from(r.entries()).sort(((t,e)=>e[1]-t[1])),a=s.reduce(((t,[e,n])=>t+n),0),l=Math.min(1,o/(a*o));let c=i;const h=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const u=t===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,h-c);if(d<4)break;this.drawLetter(i,e+1,c,n,d,u),c+=d}}drawColumnBorder(t,e,n,i){this.ctx.strokeStyle=qi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+1,e,n,i)}drawLetter(t,e,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(t),a=this.getMonomerTextColor(t);this.ctx.fillStyle=s,this.ctx.fillRect(e,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(e,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(e,n,i,o),this.drawLetterText(t,e,n,i,o,a)}drawLetterSeparators(t,e,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,e+i<e+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(t,e+i),this.ctx.lineTo(t+n,e+i),this.ctx.stroke())}drawLetterText(t,e,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,e+i/2,n+o/2))}getMonomerBackgroundColor(t){if(this.monomerLib)try{const e=this.monomerLib.getMonomerColors(this.biotype,t);if(e&&e.backgroundcolor)return e.backgroundcolor}catch(t){console.warn("Error getting background color from monomerLib:",t)}return"#CCCCCC"}getMonomerTextColor(t){const e=this.getMonomerBackgroundColor(t);try{const t=a.Color.fromHtml(e),n=a.Color.getContrastColor(t);return a.Color.toHtml(n)}catch(t){return console.warn("Error calculating contrast color:",t),"#000000"}}}class Ki extends zi{constructor(t,e=Zi.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(e,Zi.MIN_TRACK_HEIGHT,i),this.data=t,this.colorScheme=n,this.visible=t.length>0}updateData(t){this.data=t,this.visible=t.length>0}draw(t,e,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=t+n*r,h=r,u=c+h/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,h,u,e,i),l===a&&(this.ctx.fillStyle=Ui,this.ctx.fillRect(c,e,h,i)))}}drawConservationBar(t,e,n,i,o,r){if(!this.ctx)return;const s=this.data[t];this.ctx.fillStyle=ji,this.ctx.fillRect(e+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const t=Math.round(255*s);a=`rgb(255, ${t}, ${t})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(e+2,o+r-l,n-4,l),this.ctx.strokeStyle=qi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Wi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const Zi={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},Xi={BASE:Zi.DOTTED_CELL_HEIGHT+Zi.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+Zi.TITLE_HEIGHT+Zi.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP}};class Ji{constructor(t,e){this.gridColumn=e,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:t.x||0,y:t.y||0,width:t.width||0,height:t.height||0,windowStartPosition:t.windowStartPosition||1,positionWidth:t.positionWidth||15,totalPositions:t.totalPositions||5e3,headerHeight:t.headerHeight||Xi.BASE,sliderHeight:t.sliderHeight||Zi.SLIDER_HEIGHT,currentPosition:t.currentPosition||1,cellBackground:void 0===t.cellBackground||t.cellBackground,sliderColor:t.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:t.onPositionChange||((t,e)=>{}),onHeaderHeightChange:t.onHeaderHeightChange||(()=>{}),...t},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const t=this.config.headerHeight,e=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach((t=>{t.setVisible(!1),t.setHeight(Zi.DEFAULT_TRACK_HEIGHT)})),!(t<Xi.WITH_TITLE()||t<Xi.WITH_WEBLOGO()))if(t<Xi.WITH_BOTH()){if(e){e.setVisible(!0);const n=t-Xi.WITH_WEBLOGO();e.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}}else{if(e&&e.setVisible(!0),n&&n.setVisible(!0),e&&t>Xi.WITH_BOTH()){const n=t-Xi.WITH_BOTH();e.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach(((t,e)=>{this.userSelectedTracks[e]||t.setVisible(!1)})),t<Xi.WITH_WEBLOGO()&&e&&e.setVisible(!1),t<Xi.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const t=this.getTrack("conservation"),e=this.getTrack("weblogo"),n=t?.isVisible()??!1,i=e?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=Xi.WITH_TITLE()?(Zi.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&t&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&e&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(t,e,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:t,label:e,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,n+o/2,i+r/2))}handleTrackButtonClick(t,e){for(const n of this.trackButtons)if(t>=n.x&&t<=n.x+n.width&&e>=n.y&&e<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(t,e){return e<(this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0)}snapToTrackHeight(t){let e;if("weblogo"===t)e=Xi.WITH_WEBLOGO();else{if("conservation"!==t)return;e=Xi.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach(((t,e)=>{this.userSelectedTracks[e]=!1}))),"conservation"===t?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===t&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame((()=>this.redraw()))}resetToAutoMode(){this.userSelectedTracks=null;const t=this.tracks.size>0?Xi.WITH_BOTH():Xi.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame((()=>this.redraw()))}drawColumnTitle(t,e,n,i){this.ctx&&i&&this.config.headerHeight>=Xi.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(t,e,n,Zi.TITLE_HEIGHT),this.ctx.fillStyle=Wi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,t+n/2,e+Zi.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach((t=>{t instanceof Yi&&t.setHovered(-1,null)})),window.requestAnimationFrame((()=>this.redraw())))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(t,e,n,i){this.dataFrame=t,this.seqColumn=e,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(t){if(!this.isValid)return;const{x:e,y:n}=this.getCoords(t),i=this.config.positionWidth,o=Math.floor(e/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,l=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,c=l-Zi.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let h=null,u=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let f=c;for(const{id:t,track:e}of d){const i=f-e.getHeight();if(n>=i&&n<f){h=t,u=n-i;break}f=i-Zi.TRACK_GAP}let g=null;if(h){const t=this.tracks.get(h);t&&(g=t.getMonomerAt(e,u,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==h||this.previousHoverMonomer!==g)&&(this.previousHoverPosition=r,this.previousHoverTrack=h,this.previousHoverMonomer=g,h)){const t=this.tracks.get(h);t instanceof Yi&&(t.setHovered(r,g),window.requestAnimationFrame((()=>this.redraw())))}if((r!==this.currentHoverPosition||h!==this.currentHoverTrack||g!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=h,this.currentHoverMonomer=g,h)){const e=this.tracks.get(h);if(e){const n=e.getTooltipContent(r,g);if(n)return void s.tooltip.show(n,t.clientX+16,t.clientY+16)}}h&&g||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame((()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(t,e,n,i,o,r,s,a){if(Object.assign(this.config,{x:t,y:e,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(t,e,n,i),this.ctx.translate(t,e),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=Xi.WITH_TITLE();l&&Zi.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-Zi.SLIDER_HEIGHT,h=c-Zi.DOTTED_CELL_HEIGHT,u=h-Zi.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const f=this.getTrack("conservation");f&&f.isVisible()&&p.push({id:"conservation",track:f});let g=u;for(const{track:t}of p){const e=t.getHeight(),i=g-e;t.draw(0,i,n,e,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:e}),g=i-Zi.TRACK_GAP}if(this.drawDottedCells(0,h,n,Zi.DOTTED_CELL_HEIGHT,c),d.push({y:h,height:Zi.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const t=this.config.positionWidth,e=this.config.currentPosition-this.config.windowStartPosition;if(e>=0&&e<Math.floor(n/t)){const n=e*t+t/2;for(let t=0;t<d.length-1;t++){const e=d[t],i=d[t+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,e.y+e.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(t,e,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),h=e+Zi.TOP_PADDING;this.drawSlider(t,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const u=t+n*s,d=s,p=u+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(u,e,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(u,e),this.ctx.lineTo(u,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,h+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Wi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,h+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(u,e,d,i))}}drawSlider(t,e,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(t,e,n,Zi.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(t+a,e,l,Zi.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(t+o-1,e-2,3,Zi.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(t){const e=this.canvas.getBoundingClientRect();return{x:t.clientX-e.left-this.config.x,y:t.clientY-e.top-this.config.y}}isInHeaderArea(t){const{x:e,y:n}=this.getCoords(t);return e>=0&&e<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(t){this.config.positionWidth=t}isInSliderArea(t){const{y:e}=this.getCoords(t),n=this.config.headerHeight-Zi.SLIDER_HEIGHT;return e>n&&e<n+Zi.SLIDER_HEIGHT}get sliderWidth(){const t=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(t,20)}isInSliderDraggableArea(t){const{x:e,y:n}=this.getCoords(t),i=this.config.headerHeight-Zi.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+Zi.SLIDER_HEIGHT&&e>=a&&e<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",(t=>{this.isValid&&(this.isInSliderDraggableArea(t)?this.eventElement.style.cursor="grab":this.isInSliderArea(t)||this.isInHeaderArea(t)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")})),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(t){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:e,y:n}=this.getCoords(t);if(this.handleTrackButtonClick(e,n))return;if(this.isInsideColumnHeaderArea(e,n))return;const i=this.config.positionWidth,o=Math.floor(e/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,a=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,l=a-Zi.TRACK_GAP;if(n>=a||n<s)return;let c=null,h=0;const u=[],d=this.getTrack("weblogo");d&&d.isVisible()&&u.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&u.push({id:"conservation",track:p});let m=l;for(const{id:t,track:e}of u){const i=m-e.getHeight();if(n>=i&&n<m){c=t,h=n-i;break}m=i-Zi.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(e,h,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),t.stopPropagation(),t.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(t,e){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(t,!0);n.init((t=>i[t]===e))}catch(t){console.error("Error selecting rows:",t)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const t=this.canvas.getContext("2d");t?(this.ctx=t,this.tracks.forEach((e=>e.init(t)))):console.error("Failed to get 2D context from canvas")}addTrack(t,e){this.ctx&&e.init(this.ctx),this.tracks.set(t,e)}removeTrack(t){this.tracks.delete(t)}getTrack(t){return this.tracks.get(t)}updateTrack(t,e){const n=this.getTrack(t);n&&e(n)}get isValid(){const t=this.gridColumn,e=t?.grid,n=e?.horzScroll?.min||0,i=e?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=Xi.WITH_TITLE()&&e&&(Qi(t.left??0,n,i)||Qi(t.right??1/0,n,i))}handleMouseDown(t){if(!this.isValid)return;const{x:e}=this.getCoords(t);this.isInSliderDraggableArea(t)&&(this.state.isDragging=!0,this.state.dragStartX=e,this.handleSliderDrag(e),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation())}handleMouseWheel(t){if(this.isValid&&this.isInHeaderArea(t)){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e=t.shiftKey?Math.sign(t.deltaY):Math.sign(t.deltaX||t.deltaY),n=t.shiftKey?3:1,i=this.config.windowStartPosition+e*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(t){if(!this.state.isDragging||!this.isValid)return;const e=this.canvas.getBoundingClientRect(),n=t.clientX-e.left-this.config.x;this.handleSliderDrag(n),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}handleKeyDown(t){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===t.key||"ArrowRight"===t.key){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e="ArrowLeft"===t.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+e,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=e<0?n:Math.max(1,n-i+1))}else{if("Escape"!==t.key)return;this.config.currentPosition=-2,t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(t){if(!this.isValid)return;const e=this.sliderWidth,n=this.config.width-e,i=Math.max(0,Math.min(this.config.width,t)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-e/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(t){this.config.headerHeight=t}handleClick(t){if(!this.isValid)return;t.clientX,this.canvas.getBoundingClientRect().left,t.clientY,this.canvas.getBoundingClientRect().top;const{x:e,y:n}=this.getCoords(t);if(this.handleTrackButtonClick(e,n))return t.preventDefault(),void t.stopPropagation();if(!this.isInsideColumnHeaderArea(e,n)&&n<this.config.headerHeight-Zi.SLIDER_HEIGHT&&n>=0){const t=this.config.positionWidth,n=Math.round(e/t-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(t){Object.assign(this.config,t),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(t){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:Xi.BASE,WITH_TITLE:Xi.WITH_TITLE(),WITH_WEBLOGO:Xi.WITH_WEBLOGO(),WITH_BOTH:Xi.WITH_BOTH()}}}function Qi(t,e,n){return t>=e&&t<=n}class to{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){to.conservationCache=new a.LruCache(100),to.webLogoCache=new a.LruCache(100),to.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return to.lastInvalidationTime}static getChunkCacheKey(t,e,n){const i=t.dataFrame;return`${i.id}_${t.name}_f${i.filter.version}_${e}_${n}`}static getConservationChunk(t,e,n,i){return to.conservationCache.getOrCreate(i,(()=>{const o=to.getWebLogoChunk(t,e,n,i),r=new Array(n-e).fill(0);for(let i=e;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=t.defaultGapOriginal;for(const[t,e]of n.entries())t&&t!==l&&(s+=e,e>a&&(a=e));r[i-e]=s>0?a/s:0}return r}))}static getWebLogoChunk(t,e,n,i){return to.webLogoCache.getOrCreate(i,(()=>{const i=t.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let t=e;t<n;t++)o.set(t,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=t.getSplitted(i).getOriginalRegion(e,n);if(0!==r.length)for(let t=0;t<r.length;t++){const n=r[t],i=o.get(e+t);i.set(n,(i.get(n)||0)+a)}}return o}))}static getConservationForViewport(t,e,n,i){const o=new Array(i).fill(0),r=Math.floor(e/to.CHUNK_SIZE)*to.CHUNK_SIZE,s=Math.ceil(n/to.CHUNK_SIZE)*to.CHUNK_SIZE;for(let e=r;e<s;e+=to.CHUNK_SIZE){const n=Math.min(e+to.CHUNK_SIZE,i),r=to.getChunkCacheKey(t.column,e,n),s=to.getConservationChunk(t,e,n,r);for(let t=0;t<s.length&&e+t<i;t++)o[e+t]=s[t]}return o}static getWebLogoForViewport(t,e,n,i){const o=new Map,r=Math.floor(e/to.CHUNK_SIZE)*to.CHUNK_SIZE,s=Math.ceil(n/to.CHUNK_SIZE)*to.CHUNK_SIZE;for(let e=r;e<s;e+=to.CHUNK_SIZE){const n=Math.min(e+to.CHUNK_SIZE,i),r=to.getChunkCacheKey(t.column,e,n),s=to.getWebLogoChunk(t,e,n,r);for(const[t,e]of s.entries())t<i&&o.set(t,e)}return o}}class eo extends Yi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(t,e,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=t,this.maxLength=e,this.visible=t.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(t,e){const n=to.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-t)>=10||Math.abs(this.lastViewportEnd-e)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=t,this.lastViewportEnd=e,this.lastInvalidationTime=n;const o=Math.max(0,t-20),r=Math.min(this.maxLength,e+20),s=to.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(t,e,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(t,e,n,i,o,r,s,a)}}class no extends Ki{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(t,e,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=t,this.maxLength=e,this.visible=t.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(t,e){const n=to.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-t)>=10||Math.abs(this.lastViewportEnd-e)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=t,this.lastViewportEnd=e,this.lastInvalidationTime=n;const o=Math.max(0,t-20),r=Math.min(this.maxLength,e+20),s=to.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(t,e,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(t,e,n,i,o,r,s,a)}}const io=new ai;async function oo(){return await dn.getInstance()}class ro{_palette;constructor(t){this._palette=t}get(t){return this._palette[t]}}let so=null;async function ao(){null===so&&(so=async function(){const t="Bio: _package.initBio()";io.logger.debug(`${t}, start`);const e=window.performance.now(),n=await(0,Pt.j)(),i=await io.getProperties(),o=new si(i);io.properties=o;const s=await dn.getInstance(),l=await(0,Nt.ub)();l.explicit&&(l.explicit=[],await(0,Nt.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),u=s.getMonomerSets(),d=window.performance.now();io.logger.debug(`${t}, loading ET: ${d-e} ms`);const p=new Bi(s,n);io.completeInit(p,c,u,n),io.logger.debug(`${t}, end`),function(){const t=t=>{setTimeout((()=>{if(t.isDetached)return;const e=t.dataFrame;if(!e)return;const n=e.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let n=null;try{n=io.seqHelper.getSeqHandler(i)}catch(t){continue}if(!n)continue;if(n.isHelm()||n.alphabet===gt.YI.UN)continue;const o=t.col(i.name);if(!o)continue;let s=!!t.tableView&&Array.from(t.tableView.viewers).some((t=>"Sequence Position Statistics"===t.type));if(n.isMsa()){const l=(t,e)=>Number.isNaN(t)?e:t,c=()=>l(Math.max(Number.parseInt(i.getTag(gt.gp.positionShift)??"0"),0),0)+1,u=()=>l(Number.parseInt(i.getTag(gt.gp.selectedPosition)??"-2"),-2),d=()=>kt.Jy.getFontSettings(i).fontWidth;let p=0,m=0;const f=i.categories;for(let t=0;t<f.length;t++){const e=f[t];e&&e.length>m&&(m=e.length,p=t)}const g=f[p],y=n.splitter(g),b=y?y.length:30,v={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let w;w=i.length>1e5||b<50?v.WITH_TITLE:i.length>5e4?v.WITH_WEBLOGO:v.WITH_BOTH;let C=null,A=null;const S=a.debounce(h.merge(e.onFilterChanged,e.onDataChanged.pipe((0,O.filter)((t=>t?.args?.column===i)))),100).subscribe((()=>{to.clearAllCaches(),C&&(C.resetViewportTracking(),C.forceUpdate()),A&&(A.resetViewportTracking(),A.forceUpdate()),setTimeout((()=>{t.isDetached||t.invalidate()}),50)}));t.sub(S);const x=r=>{const l=[],h=new no(n,b,45,"default","Conservation");A=h,l.push({id:"conservation",track:h,priority:1});const p=new eo(n,b,45,"WebLogo");C=p,r&&(p.setMonomerLib(r),p.setBiotype(n.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new Ji({canvas:t.overlay,headerHeight:w,totalPositions:b+1,onPositionChange:(e,n)=>{setTimeout((()=>{const o=c(),r=u();if(o!==n.start&&i.setTag(gt.gp.positionShift,(n.start-1).toString()),r!==e&&(i.setTag(gt.gp.selectedPosition,e.toString()),e>=0&&!s&&t.tableView&&$()(t.dataFrame?.columns.numerical).find((t=>!0)))){s=!0;const e=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:i.name});t.tableView.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}}))},onHeaderHeightChange:e=>{t.isDetached||e<v.WITH_TITLE||setTimeout((()=>t.props.colHeaderHeight=e))}},o);m.setupTooltipHandling(),l.forEach((({id:t,track:e})=>{m.addTrack(t,e)})),m.setSelectionData(e,i,n),b>50&&(t.props.colHeaderHeight=w,setTimeout((()=>{t.isDetached||(o.width=400)}),300)),t.sub(t.onCellRender.subscribe((t=>{const e=t.cell;if(!e||!e.isColHeader||e?.gridColumn?.name!==o?.name)return;const n=t.bounds;if(!n)return;m.headerHeight=n.height;const r=d();m.positionWidth=r+8;const s=c();m.draw(n.x,n.y,n.width,n.height,u(),s,t,i.name)})))};(0,bt.pj)().then((t=>{const e=t.getMonomerLib();x(e)})).catch((t=>{r.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",t)}))}}}),1e3)},e=(r.events.onViewerAdded.subscribe((e=>{if(!(e.args&&e.args.viewer instanceof a.Grid))return;const n=e.args.viewer;t(n)})),r.shell.tableViews);for(const n of e){const e=n?.grid;e&&t(e)}}()}()),await so}function lo(t){const e=new ui(t,io.seqHelper);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();r.shell.error(e)})),e}function co(){return io.monomerLib}function ho(t){return io.seqHelper.getSeqHandler(t)}function uo(t){const e="getRegionTopMenu",n=a.Func.find({package:io.name,name:e});if(1!==n.length)throw new Error(`Package '${io.name}' func '${e}' not found`);const i=n[0].prepare({table:t.dataFrame,sequence:t});return new fi(i,io.seqHelper).widget()}async function po(t){return async function(){const t=s.label("Manage monomer libraries");return mn()(t).addClass("d4-link-action"),t.onclick=async()=>await Bn(),new a.Widget(t)}()}function mo(t){try{new fi(t,io.seqHelper).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;r.shell.error(`Get region editor error: ${e}`),io.logger.error(e,void 0,n)}}function fo(t){const e=new ti;s.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function go(t){const e=new k({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function yo(t){const e=new St({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function bo(){return new Yt}function vo(){return new Yt}function wo(){return new Yt}function Co(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===a.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);let n=io.properties?io.properties.maxMonomerLength:4;if(Rt.gp.maxMonomerLength in t.tags){const e=parseInt(t.getTag(Rt.gp.maxMonomerLength));n=isNaN(e)?n:e}if(".mm.cellRenderer.maxMonomerLength"in t.temp){const e=parseInt(t.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(e)?n:e}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(0==e)setTimeout((()=>{i.value=null}),0);else{const n=e??"",i=null==n?"":n.toString();t.temp[".mm.cellRenderer.maxMonomerLength"]=i,t.temp[".mm.cellRenderer.settingsChanged"]=Dt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=io.properties?io.properties.fontSize:12;".mm.cellRenderer.fontSize"in t.temp&&t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(o=t.temp[".mm.cellRenderer.fontSize"]);const r=s.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(e&&e>0){const n=e??12;t.temp[".mm.cellRenderer.fontSize"]=n,t.temp[".mm.cellRenderer.settingsChanged"]=Dt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:t.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.temp[".mm.cellRenderer.settingsChanged"]=Dt.s.true,t.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==t?.temp["color-code"]||t.temp["color-code"],onValueChanged:e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],onValueChanged:e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;(()=>{const e=t.meta.units;return e!==gt.Hi.HELM&&e!==gt.Hi.CUSTOM})()&&(d=s.input.bool("Multiline Rendering",{value:"true"===t.getTag("renderMultiline"),onValueChanged:e=>{t.tags.renderMultiline=e?"true":"false",t.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[r,i,l,h,c,u];d&&p.push(d);const m=s.inputs(p);return new a.Widget(m)}(t)}function Ao(t){return function(t,e,n){const i=s.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=t.cell.column.tags[gt.gp.alphabet],r=o===gt.YI.DNA||o===gt.YI.RNA?Ft.o.NUCLEOTIDE:Ft.o.AA,l={},c=n.getSeqHandler(t.cell.column),h=t.cell.rowIndex,u=c.getSplitted(h);$().count(0).take(u.length).filter((t=>!u.isGap(t))).forEach((t=>{let e=u.getCanonical(t);r===Ft.o.NUCLEOTIDE&&c.isHelm()&&"("===e[1]&&")"===e[e.length-2]&&(e=e.substring(2,e.length-2));const n=l[e]||0;l[e]=n+1}));const d=(0,hi.F)(l,r,e);return Array.from(d.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),i.appendChild(d),new a.Widget(i)}(t,io.monomerLib,io.seqHelper)}function So(){return new Zt}function xo(t,e,n,i,o){const r=new he.$(i,o,n,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunsch()}function Eo(){return new oe.oP}function To(){return new ce}function Mo(t,e,n,i){return di(t,e??null,n??null,i??null)}async function _o(t,e,n,i,o){const s=di(e,n??null,i??null,o??null);e.dataFrame.columns.add(s),await r.data.detectSemanticTypes(e.dataFrame)}async function Io(t,e,n,i,o,h,u,d,p){if(t!==r.shell.tv.dataFrame)return void r.shell.error(`Table ${t.name} is not a current table view`);if(r.shell.tv,!(0,Zn.V)(e,"Activity Cliffs"))return;const m=_t(t),f={units:e.meta.units,aligned:e.getTag(gt.gp.aligned),separator:e.getTag(gt.gp.separator),alphabet:e.getTag(gt.gp.alphabet)},g=h,y=e,b=async()=>await mt(t,y,m,"Activity cliffs",n,i,g,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,u,me,fe,ve,void 0,p),v=o===c.c.UMAP?2e5:2e4,w=o===c.c.UMAP?5e3:2e3;if(t.rowCount>v)return void r.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),A=await new Promise(((e,n)=>{t.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK((async()=>{b().then((t=>e(t))).catch((t=>n(t)))})).onCancel((()=>{e(void 0)})).show():b().then((t=>e(t))).catch((t=>n(t)))})).catch((t=>{const[e,n]=(0,Ct.AP)(t);throw io.logger.error(e,void 0,n),t})).finally((()=>{C.close()}));return A?.props?.xColumnName&&A?.props?.yColumnName&&t.col(A.props.xColumnName)&&t.col(A.props.yColumnName)&&(t.col(A.props.xColumnName).set(0,t.col(A.props.xColumnName).get(0)),t.col(A.props.yColumnName).set(0,t.col(A.props.yColumnName).get(0))),A}async function Lo(t,e,n=1,i=.6,o="Morgan"){if(t.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:t.toList(),options:{}};const{seqList:r,options:s}=await de(t,e,o,n,i);return{entries:r,options:s}}async function No(t,e){t.version!==t.temp["last-invalidated-version"]&&await(0,pe.BQ)(t,io.seqHelper,!1);const n=t.temp["monomeric-mols"],i=await r.functions.call("Chem:getMorganFingerprints",{molColumn:n}),o=new Array(i.length).fill(null);for(let t=0;t<i.length;t++){if(i.isNone(t)||!i.get(t))continue;const e=i.get(t);o[t]=U.A.fromUint32Array(e.length,new Uint32Array(e.getBuffer().buffer))}return{entries:o,options:{}}}async function Po(t,e,i,o,c,h,u,d,p){if(t.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${t.name} is not a current table view`);const m=r.shell.tv.dataFrame==t?r.shell.tv:void 0;return(0,Zn.V)(e,"Sequence Space")?(h||(h=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),u??={},await async function(t,e,i,o,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(e.length!==o.length||e.length!==h.length||e.length!==c.length||e.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?f.tableView??r.shell.tableView(t.name)??r.shell.addTableView(t):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=_t(t);function x(n,o,r){let c=null,h=null;t.columns.names().includes(S[0])?(c=t.columns.byName(S[0]),h=t.columns.byName(S[1])):(c=t.columns.add(a.Column.float(S[0],t.rowCount)),h=t.columns.add(a.Column.float(S[1],t.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??It(e,i)}))),f[l.YP]&&(A?.root&&s.setUpdateIndicator(A.root,!1),c.init((t=>r[0]?r[0][t]:void 0)),h.init((t=>r[1]?r[1][t]:void 0)));const u=n/o*100;C.update(u,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${u.toFixed(0)}%`)}async function E(){t.columns.add(a.Column.float(S[0],t.rowCount)),t.columns.add(a.Column.float(S[1],t.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??It(e,i)}),s.setUpdateIndicator(A.root,!0));const p=r.events.onViewerClosed.subscribe((t=>{const e=t.args.viewer;e?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&e?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(r.events.fireCustomEvent(Y.S,{}),p.unsubscribe(),n?.(),C.close())})),g=new Promise((async(r,s)=>{try{n=r;const s=[];let a=o,d=c,p=u;if(b&&e.every((t=>t.isNumerical))){const n=e.map((t=>t.toList())),i=new Array(t.rowCount).fill(0).map(((t,n)=>new Float32Array(e.length)));for(let o=0;o<e.length;++o)for(let e=0;e<t.rowCount;++e)i[e][o]=n[o][e];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let t=0;t<h.length;++t){const n=h[t];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,r=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:e[t],[r]:o[t],...m.preprocessingFuncArgs[t]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=e[t].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}r(await Z(s.map((t=>t.entries)),i,a,d,u,m,f[l.vb]?void 0:x))}catch(t){s(t)}})),y=await g;return C.close(),p.unsubscribe(),y}const T=await E();if(p&&T){const M=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(t,e,i,o){return Mt(this,void 0,void 0,(function*(){return new Promise((function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:t,embedY:e,minPts:o,epsilon:i}),a.onmessage=({data:{error:t,clusters:e}})=>{a.terminate(),t?s(t):r(e)}}))}))}(T[0],T[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=t.columns.getUnusedName("Cluster (DBSCAN)");t.columns.addNewString(I).init((t=>_[t].toString())),A&&(A.props.colorColumnName=I)}catch(L){r.shell.error("Clustering embeddings failed"),console.error(L)}finally{M.close()}}if(T){const N=t.columns.byName(S[0]),P=t.columns.byName(S[1]);if(N.init((t=>T[0][t])),P.init((t=>T[1][t])),g)try{const $=g.inputs[0].name,R=g.inputs[1].name;await g.prepare({[$]:N,[R]:P,...y}).call(!0)}catch(k){r.shell.error("Post-processing failed"),console.error(k)}if(A)return s.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(O){r.shell.error("Dimensionality reduction failed"),console.error(O),C.close(),A&&s.setUpdateIndicator(A.root,!1)}};return new Promise((async(e,n)=>{try{if(f.fastRowCount&&t.rowCount>f.fastRowCount&&!f[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const t=await C();e(t)}catch(t){n(t)}})).onCancel((()=>e(void 0))).show();else{const t=await C();e(t)}}catch(t){n(t)}}))}(t,[e],i,[o],[1],[h],"MANHATTAN",c,d??!1,{...u,preprocessingFuncArgs:[u.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:u?.[l.vb],tableView:m})):void 0}async function $o(t,e,n,i=!1){const o=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await so;const o=e.temp[".mm.cellRenderer.overriddenLibrary"]??io.monomerLib,r=io.seqHelper,s=io.rdKitModule;await(0,gi.V)(t,e,n,i,o,r,s)}finally{o.close()}}async function Ro(t){if(!t?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const e=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!e)throw new Error("To Atomic level Function not found");e.prepare({table:t.dataFrame,seqCol:t}).edit()}async function ko(t){return async function(t){const e=await Vi(t);if(e.errorText||!e.mol)return a.Widget.fromRoot(s.divText(e.errorText??"No structure generated"));try{const t=a.SemanticValue.fromValueType(e.mol,a.SEMTYPE.MOLECULE),n=s.panels.infoPanel(t);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=r.chem.drawMolecule(e.mol,300,300,!1);return o.style.cursor="pointer",s.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const t=window.innerWidth-200,n=window.innerHeight-200,i=r.chem.drawMolecule(e.mol,t,n,!1);s.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(t){io.logger.error(t)}return a.Widget.fromRoot(s.divText("No structure generated"))}(t)}async function Oo(t){return async function(t){const e=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Vi(t);if(o.errorText||!o.mol)return n=s.divText(o.errorText??"No structure generated"),e.close(),new a.Widget(n);const l=o.mol;i=await r.functions.call("Bio:Embed",{molecule:l});const c=wi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(t){console.warn(t)}try{i=i.replaceAll("\\n","\n");const t=new Blob([i],{type:"text/plain"}),e=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});e.style.setProperty("height","100%","important");const o=new NGL.Stage(e,{backgroundColor:"white"});o.loadFile(t,{ext:"sdf"}).then((function(t){o.setSize(300,300),t.addRepresentation("ball+stick"),t.autoView()})),n=s.div([e],{style:{aspectRatio:"1"}})}catch(t){n=s.divText("Couldn't get 3D structure")}}catch(t){n=s.divText("Couldn't get 3D structure")}return e.close(),new a.Widget(n)}(t)}function Ho(){(0,Jn.D)({},io.seqHelper).catch((t=>{const[e,n]=(0,Ct.AP)(t);if(t instanceof Xn.Ap)return r.shell.warning(t.element),void io.logger.warning(e);r.shell.error(e),io.logger.error(e,void 0,n)}))}async function Go(t=null,e=null,n){return(0,Jn.D)({col:t,clustersCol:e,...n},io.seqHelper)}async function Fo(){const t=r.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==a.SEMTYPE.MACROMOLECULE&&(io.seqHelper.getSeqHandler(t),!0))),n=async e=>{if(!(0,Zn.V)(e,"Composition"))return;const n=t.addViewer("WebLogo",{sequenceColumnName:e.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>io.seqHelper.getSeqHandler(t).isMsa())),o=s.input.choice("Column",{value:i?i.name:t[0],items:t});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK((async()=>{const t=e.find((t=>t.name==o.value))??null;t&&await n(t)})).show()}else i=e[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}function Do(t){return new yt.m(t).importFasta()}function Bo(t){return console.log(t),[]}function Vo(){const t=(0,$t.me)()[0];(0,Te.C)(t,io.seqHelper)}function Wo(t){(0,Te.C)(t,io.seqHelper)}function Uo(){return new oi}async function jo(t){const e=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let i=0;const o=[];for(const s of n)try{const e=await r.dapi.files.readAsText(t+s.fullPath),n=a.DataFrame.fromCsv(e);for(const t of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:t})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:t.name,message:`units: ${t.meta.units}`})}catch(t){o.push({file:s.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${t}`,s}async function qo(t,e){return await async function(t,e){if(await(0,te.cb)(10),!(0,Zn.V)(e,"Sequence space"))return t;const n=io.seqHelper,i=(0,vt.R)(e,n);i.name="splitToMonomers";const o=e.dataFrame;for(const t of i.columns)t.semType=Wt.uF.MONOMER,t.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=t=>{s.lastIndex=0;const e=t.match(s);return e?`${e[1]} (${parseInt(e[2]??"0")+1})`:t};for(let t=0;t<i.columns.length;t++){const n=i.columns.byIndex(t);n.semType=Wt.uF.MONOMER,n.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const r=100;let s=0;for(;o.columns.byName(n.name)&&s<r;)n.name=l(n.name),s++;o.columns.add(n)}await r.data.detectSemanticTypes(o);for(let t=0;t<i.columns.length;t++){const e=i.columns.byIndex(t);e.setTag(a.TAGS.CELL_RENDERER,"Monomer"),e.setTag(".use-as-filter","false")}return o}(t,e)}function zo(t){return io.seqHelper.getSeqMonomers(t)}function Yo(){return new Se(io.seqHelper)}function Ko(){const t=r.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Zo(){return new xe(io.seqHelper)}function Xo(){const t=r.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Jo(t){const e=(0,$t.me)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new pe.a7(e,io.seqHelper)}function Qo(t){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),r.shell.tv.grid.scrollToCell(t,0)}async function tr(t,e,n){const i=io.seqHelper;return yi(t,e,n,ft.IDENTITY,i)}async function er(t,e,n){const i=io.seqHelper;return yi(t,e,n,ft.SIMILARITY,i)}async function nr(){Bn()}async function ir(){await Vn()}async function or(){const t=await Tn.getInstance();await t.getViewRoot()}async function rr(){return await Vn(!1)}async function sr(t,e){(await(await dn.getInstance()).getFileManager()).getValidLibraryPaths().forEach((e=>{const n=e.endsWith(".json")?e.substring(0,e.length-5):e;t.item(n).onSelected.subscribe((async()=>{const t=await Tn.getInstance();await t.getViewRoot(e,!0),t.resetCurrentRowFollowing()}))}))}function ar(){(0,Me.TE)()}function lr(){return new _e._i(io.seqHelper,io.logger)}function cr(){return new _e._i(io.seqHelper,io.logger)}async function hr(){const t=a.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new Qn(t,"webLogoLargeApp"),n=await io.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function ur(){const t=a.TaskBarProgressIndicator.create("WebLogo ...");try{const t=new URLSearchParams(window.location.search),e=new Qn(t,"webLogoAggApp"),n=await io.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function dr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new mi(t,"getRegionApp");await e.init()}finally{t.close()}}async function pr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await io.files.readCsv("samples/HELM_empty_vals.csv"),n=new mi(t,"getRegionHelmApp");await n.init({df:e,colName:"HELM"})}finally{t.close()}}function mr(){const t=a.DataFrame.fromColumns((0,Lt.dW)());r.shell.addTableView(t)}function fr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(io.seqHelper,gt.Hi.FASTA)]);r.shell.addTableView(t)}function gr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(io.seqHelper,gt.Hi.HELM)]);r.shell.addTableView(t)}function yr(t,e){!function(t,e,n){const i=Object.values(gt.Hi).filter((t=>t!==gt.Hi.CUSTOM));e.group("Copy").items(i,(e=>{const i=t.column,o=t.rowIndex,s=n.getSeqHandler(i),a=e===gt.Hi.SEPARATOR?io.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:e,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${e}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e,io.seqHelper)}async function br(){await async function(){const t=await io.files.readCsv("samples/peptides-non-natural.csv");t.name="Similarity and Diversity Demo",t.col("activity").setTag("format","3 significant digits"),t.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const e=r.shell.addTableView(t);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t);const n=e.addViewer("Sequence Similarity Search",{limit:20}),i=e.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,$t.Kd)(e.grid,"sequence",500,30);const o=e.addViewer("Sequence Diversity Search",{limit:20});e.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}async function vr(){await async function(){const t=await r.functions.eval("Bio:SeqSpaceDemo"),e=await r.dapi.projects.find(t.id);await e.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}async function wr(){await async function(){const t=await io.files.readCsv("tests/helm_cyclic_cliffs.csv");t.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(t),await t.meta.detectSemanticTypes();const e=r.shell.addTableView(t);s.setUpdateIndicator(e.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Io(t,t.getCol("Sequence"),t.getCol("Activity"),96,c.c.UMAP,ue.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),mn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),e.grid.props.rowHeight=180,e.grid.col("sequence")&&(e.grid.col("sequence").width=300),e.grid.col("structure")&&(e.grid.col("structure").width=300);const o=Array.from(e.viewers).find((t=>t!==e.grid&&t.type===a.VIEWER.GRID));o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,e.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(t){!function(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;r.shell.error(e),io.logger.error(t.message,void 0,n)}(t)}finally{s.setUpdateIndicator(e.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}async function Cr(){await async function(){const t=await io.files.readCsv("samples/HELM_BI_CYCLIC.csv");t.name="To Atomic Level",await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t);const e=r.shell.addTableView(t),n=t.col("HELM");await $o(t,n,!0,!1),(0,$t.Kd)(e.grid,"molfile(HELM)",500,300,!0),(0,$t.Kd)(e.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}async function Ar(t){const e=(0,bt.uX)(t),n=JSON.stringify(e);a.Utils.download(`${t.name}.json`,n)}async function Sr(t,e){if(!t.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[t]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await oo()).getMonomerLib(),l=io.seqHelper,c=await(0,Pt.j)(),h=(await(0,gi.V)(i,n,e,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(t){const[e,n]=(0,Ct.AP)(t);throw io.logger.error(e,void 0,n),t}}async function xr(t,e){if(!t.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[t]),i=a.DataFrame.fromColumns([n]);if(!await r.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await yi(i,n,e,ft.IDENTITY,io.seqHelper)).get(0)}catch(t){const[e,n]=(0,Ct.AP)(t);throw io.logger.error(e,void 0,n),t}}async function Er(t,e,n){const i=await t.readAsString();await async function(t,e,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const s=await r.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(t),u=e?h.getCol(e):h.columns.byIndex(0);await r.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,te.cb)(0))}l>0?r.shell.warning(`detectMacromolecule failed ${l} / ${n}`):r.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,e,n)}async function Tr(){return await ao(),io.seqHelper}function Mr(t,e,n){return async function(t,e,n=!0,i){const o=io.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(e,n,io.rdKitModule,i);return r.semType=a.SEMTYPE.MOLECULE,r}(0,e,n,io.monomerLib)}function _r(){return io.logger.debug("Bio:test1() function"),{value:"value1"}}},6625:(t,e,n)=>{"use strict";n.d(e,{$:()=>r});class i{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class o{seq1;seq2;score;constructor(t,e,n){this.seq1=t,this.seq2=e,this.score=n}}class r{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",r="";const s=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=r+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:r+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const o=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[o][e].parentJ}return new o(n,i,s)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>t&&(t=this.dpGrid[i][o].value,e=i,n=o);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.setMethod(i),this.setSequences(t,e),this.setGap(n)}}},4954:(t,e,n)=>{"use strict";n.d(e,{a7:()=>m,if:()=>g,BQ:()=>y,nI:()=>f});var i=n(4328),o=n(7389),r=n(6082),s=n(8070),a=n(2003),l=n(439);const c=31;async function h(t,e,n=!1,o){const s=e.getSeqHandler(t);let a;o??=new Map;const l=s.isHelm()?e.getSeqMonomers(t):Object.keys(s.stats.freq).filter((t=>""!==t));for(let t=0;t<l.length;t++)o.has(l[t])||o.set(l[t],`${o.size+1}`);if(s.isHelm())a=await i.functions.call("HELM:getMolFiles",{col:t}),a=function(t,e,n=!1){const i=new Array(t.length);for(let o=0;o<t.length;o++){let r=0,s=0,a="\n    Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";const l=t.get(o);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const h=parseInt(l.substring(r,r+3)),u=parseInt(l.substring(r+3,r+6));a+=`M  V30 COUNTS ${h} ${u} 0 0 0\n`,a+="M  V30 BEGIN ATOM\n";for(let t=0;t<h;t++){r=l.indexOf("\n",r)+1+c,s=l.indexOf(" ",r);const i=l.substring(r,s);a+=n?`M  V30 ${t+1} R${e.get(i)} 0.000 0.000 0 0\n`:`M  V30 ${t+1} At 0.000 0.000 0 0 MASS=${e.get(i)}\n`}a+="M  V30 END ATOM\n",a+="M  V30 BEGIN BOND\n";for(let t=0;t<u;t++){r=l.indexOf("\n",r)+1;const e=parseInt(l.substring(r,r+3).trim()),n=parseInt(l.substring(r+3,r+6).trim());a+=`M  V30 ${t+1} ${parseInt(l.substring(r+6,r+9).trim())} ${e} ${n}\n`}a+="M  V30 END BOND\n",a+="M  V30 END CTAB\n",a+="M  END",i[o]=a}return i}(a,o,n);else{a=new Array(t.length);for(let e=0;e<t.length;e++){const t=u(s.getSplitted(e),o,n);a[e]=t}}return r.Column.fromStrings("monomericMols",a)}function u(t,e,n=!1){let i="\n  Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";i+=`M  V30 COUNTS ${t.length} ${t.length?t.length-1:0} 0 0 0\n`,i+="M  V30 BEGIN ATOM\n";for(let o=0;o<t.length;o++){const r=t.getCanonical(o);r!==l._S&&(i+=n?`M  V30 ${o+1} R${e.get(r)} 0.000 0.000 0 0\n`:`M  V30 ${o+1} At 0.000 0.000 0 0 MASS=${e.get(r)}\n`)}i+="M  V30 END ATOM\n",i+="M  V30 BEGIN BOND\n";for(let e=0;e<t.length-1;e++)i+=`M  V30 ${e+1} 1 ${e+1} ${e+2}\n`;return i+="M  V30 END BOND\n",i+="M  V30 END CTAB\n",i+="M  END",i}var d=n(4870);const p="substr_helm";class m{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(t,e){this.seqHelper=e,this.col=t[0],this.createUI()}editHelmLinkAction(){(0,d.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(p,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const t=this.units===a.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,d.Ku)(this.inputsDiv,t)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const t=this.dialog.root.getElementsByClassName("notation-text")[0];t&&(t.textContent=`Notation: ${this.units}`)}createUI(){const t=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:t,value:this.col,onValueChanged:t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()},filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const e=r.DataFrame.create(1);e.columns.addNewString(p).init((t=>"")),e.col(p).semType=this.col.semType,e.col(p).meta.units=a.Hi.HELM,this.grid=e.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,n=this.units===a.Hi.HELM?e.get(p,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),t=this.units===a.Hi.HELM?await g(n,this.col,this.seqHelper):f(n,this.col),this.col.dataFrame.filter.and(t)})).show()}}function f(t,e,n){const i=n?function(t,e){const n=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=t.charAt(0)===e,o=t.charAt(t.length-1)===e,r=t.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(t,n):t,o=r.BitSet.create(e.length);for(let n=0;n<e.length;n++){const r=e.get(n);(r.match(i)||r===t)&&o.set(n,!0,!1)}return o}async function g(t,e,n){e.version!==e.temp["last-invalidated-version"]&&await y(e,n,!0);const o=r.Column.string("helm",1).init((e=>t));o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=a.Hi.HELM;const s=await h(o,n,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function y(t,e,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);try{await(0,s.cb)(10);const i=new Map,o=await h(t,e,n,i);t.temp["monomeric-mols"]=o,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version}finally{i.close()}}},966:(t,e,n)=>{"use strict";n.d(e,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(6723);function s(t,e,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,h]=a(t,e,l,n,o);return s&&!c&&i.shell.warning(h),c}function a(t,e,n,r=[],s=[]){let a=!0,l="";if(t.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(t),o=i.notation;if(r.length>0&&!r.some((t=>o.toUpperCase()==t.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==r.length?"any notation":`notation${r.length>1?"s":""} ${r.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const t=i.alphabet;s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(t,e,n)=>{"use strict";n.d(e,{HX:()=>h,J:()=>a,b9:()=>c,uF:()=>r});var i,o,r,s,a,l=n(8152);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(o||(o={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(t){t.CELL_CHANGING="isCellChanging"}(s||(s={})),function(t){t.SEPARATOR="."}(a||(a={}));const c="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(t,e,n)=>{"use strict";n.d(e,{C:()=>u});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,h=[];function u(t,e){let n=t??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=e.getSeqHandler(n),u=s.notation;const d=o.divText("Current notation: "+u,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=o.input.column("Column",{table:r.shell.t,value:n,filter:t=>t.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:t=>(n=t,s=e.getSeqHandler(n),u=s.notation,u===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+u,g=p.filter((t=>t!==u)),v=o.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),c?.clear(),void c?.add(o.div([d,m.root,v.root,y.root])))}),f=["-",".","/"];let g=p.filter((t=>t!==u));const y=o.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=o.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=o.dialog("Convert Sequence Notation").add(o.div([d,m.root,v.root,y.root])).onOK((async()=>{const t=v.value,i=t===l.Hi.SEPARATOR?y.value:void 0;await async function(t,e,n,i){const o=e.getSeqHandler(t).convert(n,i);t.dataFrame.columns.add(o);const s=await r.functions.call("Bio:detectMacromolecule",{col:o});return s&&(o.semType=s),await r.data.detectSemanticTypes(t.dataFrame),o}(n,e,t,i)})).show({x:350,y:100}),h.push(c.onClose.subscribe((t=>{h.forEach((t=>{t.unsubscribe()})),h=[],c=null}))))}},536:(t,e,n)=>{"use strict";n.d(e,{Z:()=>o});var i=n(6956);class o{constructor(t){const e=t.split(i.xe).filter((t=>t));e.forEach((t=>this.validateConnectionItem(t))),this.connectionItems=e}connectionItems;validateConnectionItem(t){const e="(PEPTIDE|RNA)",n=new RegExp(`${e}[0-9]+,${e}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!t.match(n))throw new Error(`Cannot parse connection item from ${t}`)}getConnectionData(){const t=[];return this.connectionItems.forEach((e=>{const n=[],i=e.split(",");i[2].split("-").forEach(((t,e)=>{const o=i[e],r=t.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})})),t.push(n)})),t}}},6956:(t,e,n)=>{"use strict";n.d(e,{mP:()=>r,pk:()=>o,xe:()=>i});const i="|",o="$",r="H"},9099:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(536),o=n(6956),r=n(9034);class s{helmString;constructor(t){this.helmString=t;const e=this.helmString.split(o.pk),n=e[0].split(o.xe);this.simplePolymers=n.map((t=>new r.d(t))),this.connectionList=new i.Z(e[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const t=this.simplePolymers.map((t=>t.monomers.length)).reduce(((t,e)=>t+e),0),e=Array.from({length:t},(()=>[]));return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,i=t.rGroupId;e[n].push(i)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(t){return this.getSimplePolymerByMonomerIdx(t).polymerType}getSimplePolymerByMonomerIdx(t){const e=this.getMonomerIdxShifts(),n=Object.values(e).sort(((t,e)=>t-e)).find((e=>t>=e));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${t}`);const i=Object.keys(e).find((t=>e[t]===n));return this.simplePolymers.find((t=>t.id===i))}shiftBondMonomerIds(t,e){e.forEach((e=>{e.forEach((e=>{e.monomerIdx+=t}))}))}getMonomerIdxShifts(){const t={};let e=0;return this.simplePolymers.forEach((n=>{t[n.id]=e,e+=n.monomers.length})),t}getBondData(){const t=this.getMonomerIdxShifts(),e=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),o=t[n.id];this.shiftBondMonomerIds(o,i),e.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((e=>{const n=t[e.polymerId],o=e.bond;o.monomerIdx+=n,i.push(o)})),e.push(i)})),e}}},9034:(t,e,n)=>{"use strict";n.d(e,{d:()=>o});var i=n(8438);class o{simplePolymer;isNucleotideSequence=!1;constructor(t){this.simplePolymer=t,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:e,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=e,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const t=new RegExp("(PEPTIDE|RNA)[0-9]+{"),e=this.simplePolymer.match(t);if(!e)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return e[1]}getIdx(){const t=new RegExp(`${this.polymerType}([0-9]+){`),e=this.simplePolymer.match(t);if(!e)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(e[1])}getMonomerSymbolsAndTypes(){const t=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),e=this.simplePolymer.replace(t,"").split("."),n=[],o=[];return e.forEach((t=>{if(this.isNucleotideSequence){const e=t.split(/\(|\)/).filter((t=>!!t)).map((t=>(0,i.D)(t)));n.push(...e),e.forEach(((t,e)=>o.push(e%3==1?"Branch":"Backbone")))}else n.push((0,i.D)(t)),o.push("Backbone")})),{monomers:n,monomerTypes:o}}getBondData(){const t=[],e=this.monomerTypes.map(((t,e)=>{if("Backbone"===t)return e})).filter((t=>void 0!==t)),n=this.monomerTypes.map(((t,e)=>{if("Branch"===t)return e})).filter((t=>void 0!==t));for(let n=0;n<e.length-1;n++){const i=e[n],o=e[n+1];t.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let e=0;e<n.length;e++){const i=n[e],o=i-1;t.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return t}}},8604:(t,e,n)=>{"use strict";n.d(e,{Es:()=>o,G3:()=>s,gt:()=>r,so:()=>i});const i="System:AppData/Bio/monomer-libraries/",o="System:AppData/Bio/monomer-sets/",r="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json",s={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619:(t,e,n)=>{"use strict";n.d(e,{D:()=>M});var i=n(4328),o=n(6082),r=n(7389),s=n(8070),a=n(2003),l=n(608),c=n(8152),h=n(966),u=n(4139),d=n(5072),p=n.n(d),m=n(7825),f=n.n(m),g=n(7659),y=n.n(g),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),A=n(1113),S=n.n(A),x=n(6369),E={};E.styleTagTransform=S(),E.setAttributes=v(),E.insert=y().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=C(),p()(x.A,E),x.A&&x.A.locals&&x.A.locals;var T=n(6723);async function M(t,e){return new Promise((async(n,a)=>{t.clustersCol??=null,t.pepsea??={},t.pepsea.method??=u.HX.pepsea.method,t.pepsea.gapOpen??=u.HX.pepsea.gapOpen,t.pepsea.gapExtend??=u.HX.pepsea.gapExtend;const h=t.col?.dataFrame??i.shell.t;if(!h){const t="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(t)))}const d=t.col??h.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(null==d){const t="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(t)))}const p=r.input.choice("Method",{value:t.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=r.input.float("Terminal gap",{value:t?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const f=r.p(`Kalign version: ${u.b9}`,"kalign-version"),g=r.input.float("Gap open",{value:t.pepsea.gapOpen});g.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.input.float("Gap extend",{value:t.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=r.input.bool("Selected Rows Only",{value:!1}),v=r.inputs([g,y,m]),w=r.button("Alignment parameters",(()=>{v.hidden=!v.hidden,[g,y,m].forEach((t=>{t.root.style.removeProperty("max-width"),t.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");w.classList.add("msa-params-button"),v.hidden=!0,w.prepend(r.icons.settings((()=>null)));const C=[p.root.style],A=[m.root.style,f.style];let S,x=d;const E=r.input.column("Sequence",{table:h,value:d,onValueChanged:async t=>{if(!t||t.semType!==o.SEMTYPE.MACROMOLECULE)return L.disabled=!0,await(0,s.cb)(0),void(E.value=x);x=t,L.disabled=!1,S=await I(E.value,h,e,C,A,p,T,g,y,m,b)},filter:t=>t.semType===o.SEMTYPE.MACROMOLECULE});E.setTooltip("Sequences column to use for alignment");const T=r.input.column("Clusters",{table:h,value:t.clustersCol});T.nullable=!0;const M=r.dialog("MSA").add(E).add(T).add(p).add(v).add(w).add(b).add(f).onOK((async()=>{await _(E,h,S,n,a)})),L=M.getButton("OK");if(E.fireChanged(),t.col)return S=await I(t.col,h,e,C,A,p,T,g,y,m,b),void await _(E,h,S,n,a);M.show()}))}async function _(t,e,n,r,s){let a=null;const l=o.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(t.fireChanged(),t.value.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return s("PepSeA container has not started");e.columns.add(a),await i.data.detectSemanticTypes(e),r(a)}catch(t){s(t)}finally{l.close()}}async function I(t,e,n,r,s,d,p,m,f,g,y){try{if(t.semType!==o.SEMTYPE.MACROMOLECULE)return;const i=e.columns.getUnusedName(`msa(${t.name})`);if((0,h.l)(t,t.name,n,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT])[0]){L(r,s,"kalign"),m.value=null,f.value=null,g.value=null;const o=n.getSeqHandler(t),c=o.isFasta()?t:o.convert(a.Hi.FASTA);return async()=>await(0,l.eE)(e,c,!1,i,p.value,void 0,void 0,void 0,y.value)}if((0,h.l)(t,t.name,n,[a.Hi.HELM],[])[0])return L(r,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,f.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(e,t,i,d.value,m.value,f.value,p.value,void 0,y.value);if((0,h.l)(t,t.name,n,[a.Hi.SEPARATOR],[a.YI.UN])[0]){const o=n.getSeqHandler(t).convert(a.Hi.HELM);return L(r,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,f.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(e,o,i,d.value,m.value,f.value,p.value,void 0,y.value)}return m.value=null,f.value=null,g.value=null,void L(r,s,"kalign")}catch(t){const e=t instanceof Error?t.message:t.toString();i.shell.error(e),T._package.logger.error(e)}}function L(t,e,n){if("kalign"===n){for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}else{for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}}},608:(t,e,n)=>{"use strict";n.d(e,{Ap:()=>H,aZ:()=>B,eE:()=>F});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),h=Symbol("Comlink.endpoint"),u=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),p=t=>"object"==typeof t&&null!==t||"function"==typeof t,m=new Map([["proxy",{canHandle:t=>p(t)&&t[c],serialize(t){const{port1:e,port2:n}=new MessageChannel;return f(t,e),[n,[n]]},deserialize:t=>(t.start(),y(t))}],["throw",{canHandle:t=>p(t)&&d in t,serialize({value:t}){let e;return e=t instanceof Error?{isError:!0,value:{message:t.message,name:t.name,stack:t.stack}}:{isError:!1,value:t},[e,[]]},deserialize(t){throw t.isError?Object.assign(new Error(t.value.message),t.value):t.value}}]]);function f(t,e=self){e.addEventListener("message",(function n(i){if(!i||!i.data)return;const{id:o,type:r,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const e=s.slice(0,-1).reduce(((t,e)=>t[e]),t),n=s.reduce(((t,e)=>t[e]),t);switch(r){case"GET":l=n;break;case"SET":e[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(e,a);break;case"CONSTRUCT":l=function(t){return Object.assign(t,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:e,port2:n}=new MessageChannel;f(t,n),l=function(t,e){return A.set(t,e),t}(e,[e])}break;case"RELEASE":l=void 0;break;default:return}}catch(t){l={value:t,[d]:0}}Promise.resolve(l).catch((t=>({value:t,[d]:0}))).then((t=>{const[i,s]=S(t);e.postMessage(Object.assign(Object.assign({},i),{id:o}),s),"RELEASE"===r&&(e.removeEventListener("message",n),g(e))}))})),e.start&&e.start()}function g(t){(function(t){return"MessagePort"===t.constructor.name})(t)&&t.close()}function y(t,e){return v(t,[],e)}function b(t){if(t)throw new Error("Proxy has been released and is not useable")}function v(t,e=[],n=function(){}){let i=!1;const o=new Proxy(n,{get(n,r){if(b(i),r===u)return()=>E(t,{type:"RELEASE",path:e.map((t=>t.toString()))}).then((()=>{g(t),i=!0}));if("then"===r){if(0===e.length)return{then:()=>o};const n=E(t,{type:"GET",path:e.map((t=>t.toString()))}).then(x);return n.then.bind(n)}return v(t,[...e,r])},set(n,o,r){b(i);const[s,a]=S(r);return E(t,{type:"SET",path:[...e,o].map((t=>t.toString())),value:s},a).then(x)},apply(n,o,r){b(i);const s=e[e.length-1];if(s===h)return E(t,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(t,e.slice(0,-1));const[a,l]=C(r);return E(t,{type:"APPLY",path:e.map((t=>t.toString())),argumentList:a},l).then(x)},construct(n,o){b(i);const[r,s]=C(o);return E(t,{type:"CONSTRUCT",path:e.map((t=>t.toString())),argumentList:r},s).then(x)}});return o}function w(t){return Array.prototype.concat.apply([],t)}function C(t){const e=t.map(S);return[e.map((t=>t[0])),w(e.map((t=>t[1])))]}const A=new WeakMap;function S(t){for(const[e,n]of m)if(n.canHandle(t)){const[i,o]=n.serialize(t);return[{type:"HANDLER",name:e,value:i},o]}return[{type:"RAW",value:t},A.get(t)||[]]}function x(t){switch(t.type){case"HANDLER":return m.get(t.name).deserialize(t.value);case"RAW":return t.value}}function E(t,e,n){return new Promise((i=>{const o=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");t.addEventListener("message",(function e(n){!n.data||!n.data.id||n.data.id!==o||(t.removeEventListener("message",e),i(n.data))})),t.start&&t.start(),t.postMessage(Object.assign({id:o},e),n)}))}const T="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{t.config.printStream?postMessage({type:"biowasm",value:{stdout:i}}):e.stdout+=i+`
`},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";t.config.printStream?postMessage({type:"biowasm",value:{[s]:i}}):e[s]+=i+`
`}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",M=typeof window<"u"&&window.Blob&&new Blob([atob(T)],{type:"text/javascript;charset=utf-8"});function _(){const t=M&&(window.URL||window.webkitURL).createObjectURL(M);try{return t?new Worker(t):new Worker("data:application/javascript;base64,"+T)}finally{t&&(window.URL||window.webkitURL).revokeObjectURL(t)}}const I={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class L{constructor(t,e={}){if(null==t)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(t)||(t=[t]),e=Object.assign({},I,e),t=t.map(this._parseTool),"stg"===e.env&&(e.urlCDN=e.urlCDNStg),this.tools=t,this.config=e,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const t=new _;this.callback&&(t.onmessage=t=>{"biowasm"===t.data.type&&this.callback(t.data.value)});const e=y(t);return e.tools=this.tools,e.config=this.config,await e.init(),e}_parseTool(t){if("string"!=typeof t)return t;const e=t.split("/");if(2!=e.length&&3!=e.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:e[0],program:3==e.length?e[1]:e[0],version:e[e.length-1]}}}var N=n(3629);class P{static getAvailableScales(){return Object.entries(this.scales).map((([t,e])=>t))}static getScale(t){return(0,N.vA)(!(void 0===this.scales[t]),`Scale '${t}' was not found.`),this.scales[t]}}P.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class ${constructor(t="categorial"){this.aa2num=P.getScale(t),this.num2aa={},Object.entries(this.aa2num).forEach((([t,e])=>this.num2aa[e]=t))}static _truncateSequence(t){let e=0,n=t.length;const i=["NH2","COOH"];if(t.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==t[n],`Wrong sequence format: ${i[0]} without following '-' in '${t}'.`),e=n}if(t.endsWith(i[1])){const e=i[1].length+1;(0,N.vA)("-"==t[n-e],`Wrong sequence format: ${i[1]} without '-' precending in '${t}'.`),n-=e}return t.substring(e,n)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return $._dropDefises($._truncateSequence(t))}encode(t){const e=t.length,n=new Array(e).fill(0);for(let i=0;i<e;++i){const e=t[i];(0,N.vA)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),n[i]=this.encodeLettter(e)}return n}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let n=0;n<t.length;++n){const i=t[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${t}'`),e+=this.num2aa[i]}return e}}var R=n(4139);const k="input.fa",O="result.fasta";class H extends Error{element;constructor(t,e){super(t.innerText,e),this.element=t}}function G(t){return t.reduce(((t,e,n)=>t+`>sample${n+1}\n${e}\n`),"")}async function F(t,e,n=!1,i="",r=null,s,c,h,u){let d=e.toList();n&&(d=d.map((t=>$.clean(t).replace(/\-/g,""))));const p=e.length;r??=o.Column.string("Clusters",p).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const m=r.categories,f=r.getRawData(),g=new Array(m.length),y=new Array(m.length);if(u){const e=t.selection;if(0===e.length)throw new Error("No selected rows in the table.");for(let t=-1;-1!==(t=e.findNext(t,!0));){const e=f[t];(g[e]??=[]).push(d[t]),(y[e]??=[]).push(t)}}else for(let t=0;t<p;++t){const e=f[t];(g[e]??=[]).push(d[t]),(y[e]??=[]).push(t)}B(y,m);const b=await new L(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),v=o.Column.string(i,p);for(let t=0;t<m.length;++t){const e=g[t];if(!e||0===e.length)continue;const n=G(e);await b.fs.writeFile(k,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==h?` --tgpe ${h}`:""}`,o=await b.exec(`kalign ${k} -f fasta -o ${O}${i}`);console.warn(o);const r=await b.cat(O);if(!r){const t=D(o,1);throw new Error(t)}const l=new a.m(r).sequencesArray,u=y[t];for(let t=0;t<l.length;++t)v.set(u[t],l[t])}const w=e.meta.units,C=e.getTag(l.gp.alphabet);return v.meta.units=w,v.setTag(l.gp.aligned,"SEQ.MSA"),v.setTag(l.gp.alphabet,C),v.semType=o.SEMTYPE.MACROMOLECULE,v}function D(t,e){const n=[],i=/^.+ERROR : (.+)$/gm;let o;for(;null!=(o=i.exec(t))&&(void 0===e||n.length<e);)n.push(o[1]);return n.join("\n")}function B(t,e){const n=t.map(((t,e)=>[t,e])).filter((([t,e])=>1==t.length)).map((([t,e])=>e));if(n.length>0){const t=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map((t=>{let o=e[t];return o.length>25&&(o=o.slice(0,25)+"..."),i.divText(`"${o}"${t<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new H(t)}}},8152:(t,e,n)=>{"use strict";n.d(e,{GD:()=>d,ZY:()=>h});var i=n(4328),o=n(6082),r=n(2003),s=n(608),a=n(4139),l=n(6723);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},h=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],u=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(t,e,n,i="ginsi",l=1.53,h=0,d=null,m,f=!1){const g=await c.getDockerContainer(),y=e.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,v=d.getRawData(),w=new Array(b.length),C=new Array(b.length);if(f){const n=t.selection;for(let t=-1;-1!==(t=n.findNext(t,!0));){const n=v[t];if(!b[n])continue;const i=n,o=e.get(t);o&&((w[i]??=[]).push({ID:t.toString(),HELM:o}),(C[n]??=[]).push(t))}}else for(let t=0;t<y;++t){const n=v[t];if(!b[n])continue;const i=n,o=e.get(t);o&&((w[i]??=[]).push({ID:t.toString(),HELM:o}),(C[n]??=[]).push(t))}(0,s.aZ)(C,b);const A=new Array(y).fill(null);for(const t of w){if(!t||0===t.length)continue;const e=(await p(g.id,t,i,l,h,m)).Alignment;for(const t of e)A[parseInt(t.ID)]=Object.entries(t).filter((t=>!u.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(a.J.SEPARATOR)}const S=o.Column.fromStrings(n,A);return S.meta.units=r.Hi.SEPARATOR,S.setTag(r.gp.separator,a.J.SEPARATOR),S.setTag(r.gp.aligned,"SEQ.MSA"),S.setTag(r.gp.alphabet,r.YI.UN),S.setTag(r.gp.alphabetIsMultichar,"true"),S.semType=o.SEMTYPE.MACROMOLECULE,S}async function p(t,e,n,o,r,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,h=window.performance.now(),u=await i.dapi.docker.dockerContainers.fetchProxy(t,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-h} ms`);const p="application/json"===u.headers.get("content-type");if(!u.ok&&p){const t=await u.json(),e=t["pepsea-error"];if(e)throw new Error(`PepSeA error: ${e}`);const n=t["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(u.statusText)}if(!u.ok&&!p){const t=await u.text();throw new Error(`Error: ${t}`)}if(!p){const t=await u.text();throw new Error(`Error: PepSeA expected JSON response, got '${t}'.`)}const m=await u.json();if("pepsea-stderr"in m){const t=m["pepsea-stderr"];s?.warning(t)}return m}},3890:(t,e,n)=>{"use strict";n.d(e,{TE:()=>h});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(6723);const c=60;function h(){const t=r.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),n=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),s=n?[n.name]:[],h=o.input.multiChoice("Seq id columns",{value:s,items:e.map((t=>t.name))}),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()})).toArray(),p=d.length>0?d[0].name:[],m=o.input.choice("Seq column",{value:p,items:d.map((t=>t.name))}),f=o.input.int("FASTA line width",{value:c});o.dialog({title:"Save as FASTA"}).add(o.inputs([h,m,f])).onOK((()=>{const e=h.value?h.value.map((e=>t.columns.byName(e).column)):[],n=m.value?t.columns.byName(m.value).column:null,i=f.value??c;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=function(t,e,n=c,i="\n"){const o=[];for(let r=0;r<e.length;r++){const s=t.map((t=>t.get(r).toString())).join("|"),a=u(e.getSplitted(r),n);o.push(`>${s}${i}`);for(const t of a)o.push(`${t}${i}`)}return"".concat(...o)}(e,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${t.dataFrame.name}.fasta`),s.click()})).show()}function u(t,e=c){let n=0;const i=t.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(t.length-n,e)).map((e=>t.getOriginal(e))).toArray(),r=i.map((t=>t.length>1?`[${t}]`:t)).reduce(((t,e)=>t+e),"");o.push(r),n+=i.length}return o}},8754:(t,e,n)=>{"use strict";n.d(e,{V:()=>h});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function h(t,e,n,h,u,d,p){let m;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(e);let o,a;i.isHelm()?o=e:(a=e.name,e.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,t.columns.add(o,!1));try{m=await n.helmToAtomicLevel(o,!0,!0,u)}finally{o!==e&&(t.columns.remove(o.name),e.name=a)}}else{if(!(0,l.l)(e,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,o.C4)(t,e,u,d,p)}if(m.molCol){const o=(0,c.qj)(t,e.name);m.molCol.name=o,t.columns.add(m.molCol,!0),await(0,a.Qc)(e,m.molCol,u,d,p,n),m.molCol.setTag(".sequence-src-highlight-monomers",String(h)),await i.data.detectSemanticTypes(t)}return m}},4870:(t,e,n)=>{"use strict";n.d(e,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const t=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null===t?(i.shell.error("Current table does not contain macromolecules"),[]):t}function s(t,e){t.innerHTML="",t.append(e)}function a(t,e,n,i,o){const r=()=>{const o=t.col(e);o&&(o.width=n),i&&(t.props.rowHeight=i)};if(o)return void r();const s=t.onAfterDrawOverlay.subscribe((()=>{s.unsubscribe(),setTimeout((()=>{r()}))}))}},250:(t,e,n)=>{"use strict";n.d(e,{n5:()=>C,oP:()=>_});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),h=n(1858),u=n(2003),d=n(4326);function p(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?p(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var m=n(8070),f=n(7602),g=n(439),y=n(6882);var b=n(6723);function v(t,e,n){return Math.abs(t-e)<=n}var w,C,A=n(6307);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const n=this.getBoundingClientRect();return new r.Point((t.clientX-n.left)*e,(t.clientY-n.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class S{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(t=0,e){this.value=this.rowCount=t,this.bounds=e}push(t){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=t,++this.valueIdx}aggregate(t){this.value=t(this.valueList)??0,this.valueList=null}}class x{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(t,e,n,i){this.pos=t,this.name=e,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new S),e}aggregate(t){const e=function(t){return e=>{const n=function(t){let e;const n="agg";return e=t instanceof Float32Array?r.Column.fromFloat32Array(n,t):t instanceof Int32Array?r.Column.fromInt32Array(n,t):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,t),e}(e);return n.aggregate(t)}}(t);for(const[t,n]of Object.entries(this._freqs))n.aggregate(e)}getMinValue(){return Math.min(...Object.values(this._freqs).map((t=>t.value)))}calcPlotValue(t){for(const e of Object.values(this._freqs))e.plotValue=e.value-t}calcHeights(t){this.sumPlotValue=0;for(const t of Object.values(this._freqs))this.sumPlotValue+=t.plotValue;if(this.sumPlotValueForHeight=0,t===d.fH.Entropy){const t=Object.keys(this._freqs).length,e=.01*this.sumPlotValue,n=e/t;for(const t of Object.values(this._freqs)){const i=(t.plotValue+n)/(this.sumPlotValue+e);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(t===d.fH.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=t}}calcScreen(t,e,n,i,o,s,a,l,c){const h=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let u=c*l+(n-h-1);const p=Object.entries(this._freqs).sort(((t,e)=>t[0]!==g._S&&e[0]!==g._S?e[1].value-t[1].value:t[0]===g._S&&e[0]===g._S?0:t[0]===g._S?-1:1));for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((t-e)*l*s,u,a*l,n),u+=n}}render(t,e,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==g._S){const c=(0,u.zS)(a,s),h=l.bounds,d=h.left;let p=y.S$;r&&(p=r.getMonomerTextColor(o,a)),t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(d,h.top,h.width,h.height),t.fillStyle=p,t.textAlign="left",t.font=e;const m=t.measureText(c);t.setTransform(h.width/m.width,0,0,h.height/i,d,h.top),t.fillText(c,0,-n)}}getMonomerAt(t,e){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(t,e)));return n?n[0]:void 0}buildCompositionTable(t,e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,A.F)(Object.assign({},...Object.entries(this._freqs).map((([t,e])=>({[t]:e.rowCount})))),t,e)}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(w||(w={})),function(t){t.sequenceColumnName="sequenceColumnName",t.valueAggrType="valueAggrType",t.valueColumnName="valueColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.maxMonomerLetters="maxMonomerLetters",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(C||(C={}));const E=d.Fo;var T;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(T||(T={}));const M=new class{render=20};class _ extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,E.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const t=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],e=Object.values(r.AGG).filter((e=>!t.includes(e)));this.valueColumnName=this.string(C.valueColumnName,E.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,E.valueAggrType,{category:w.DATA,choices:e,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,E.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,E.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,E.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,E.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,E.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,E.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,E.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,E.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,E.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,E.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,E.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,E.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,E.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,E.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,E.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,E.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,E.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,E.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",(0,b.getMonomerLibHelper)().then((t=>{this.monomerLib=t.getMonomerLib(),this.render(T.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(T.Render,"monomerLib changed")})))})),this.viewSyncer=new f.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const t=`${this.toLog()}.setData()`;b._package.logger.debug(`${t}, in`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),b._package.logger.debug(`${t}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${t} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,M.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(T.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(t){const e={width:t.target.clientWidth,height:t.target.clientHeight};this.lastSize.width==e.width&&this.lastSize.height==e.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(e)}, start `),this.render(T.Layout,"rootOnSizeChanged")),this.lastSize=e}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((t=>t.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(T.Freqs,"updateSeqCol()"),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let t;switch(this.filterSource){case d.lT.Filtered:t=this.dataFrame.filter;break;case d.lT.Selected:t=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.calcLayoutNoFitArea(t),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=e*t,this.canvas.height=n*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;let e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e);this.fitArea&&e<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/e),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=e>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*t,this.canvas.height=i*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*t,this.canvas.height=a*t}safeUpdateSlider(t,e,n,i){v(t,this.slider.minRange,.1)&&v(e,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(t,e,n,i)}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(T.Freqs,`onPropertyChanged( ${t.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(T.Layout,`onPropertyChanged(${t.name})`);break;case C.backgroundColor:this.render(T.Render,`onPropertyChanged(${t.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const t=`${this.toLog()}.detach()`;b._package.logger.debug(`${t}, in`);const e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),e())})),b._package.logger.debug(`${t}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const n=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,t.y);return void 0===r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((t=>!t.hasMonomer(g._S)||t.getFreq(g._S).rowCount!==t.sumRowCount)).toArray())}requestedRenderLevel=T.Freqs;renderRequest=new h.Subject;renderRequestSub;render(t,e){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${t}, reason='${e}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,t),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(t){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${t} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const e=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(t>=T.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.seqCol.getTag(u.gp.positionNames),e=this.seqCol.getTag(u.gp.positionLabels);let n;!t&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):t&&this.endPositionName&&(n=t.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((t=>{const e=this.seqHandler.getSplitted(t,n);return i.get(t)&&e?e.length:0})).reduce(((t,e)=>Math.max(t,e)),0);this.positionNames=t?t.split(u.z1).map((t=>t.trim())):[...Array(o).keys()].map((t=>`${t+1}`)),this.positionLabels=e?e.split(u.z1).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let t=0;t<s;t++){const e=this.positionNames[this.startPosition+t],n=this.positionLabels?this.positionLabels[this.startPosition+t]:void 0;this.positions[t]=new x(this.startPosition+t,e,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let t=0;t<s;++t){for(const e of l){const n=this.seqHandler.getSplitted(e),i=t+this.startPosition<n.length?n.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?g._S:i,r=this.positions[t],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let e=null;try{e=this.dataFrame.getCol(this.valueColumnName),e.matches("numerical")||(e=null)}catch{e=null}if(e){for(const n of l){const i=this.seqHandler.getSplitted(n),o=t+this.startPosition<i.length?i.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?g._S:o,s=e.get(n);this.positions[t].getFreq(r).push(s)}this.positions[t].aggregate(this.valueAggrType)}}const h=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((t=>t.getMinValue()))));for(let t=0;t<s;++t)this.positions[t].calcPlotValue(h),this.positions[t].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(e),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));t>=T.Layout&&((t,e,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==t&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(t)}else a=Math.max(...c().count(t).takeWhile((t=>t<=e)).map((t=>this.positions[t].sumPlotValueForHeight)));for(let i=t;i<=e;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const t=10*e;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${t.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(t,e,n,i,o,r,s,a){t.save();try{t.textAlign="center";let l=null,c=null;for(let e=Math.floor(s);e<=Math.floor(a);e++){const n=r[e],i=t.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?o:Math.max(c,o)}const h=l<i*e-2?1:(i*e-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],u=(l-s)*n*e+i*e/2,d=(o*e-c)/2;t.setTransform(h,0,0,1,u,d),t.measureText(a.label),t.fillText(a.label,0,0)}}finally{t.restore()}}(a,e,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let t=o;t<=s;t++)this.positions[t].render(a,i,l,c,h,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${t} ), end`)}}renderRequestOnDebounce(t){const e=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=T.None,this.viewSyncer.sync(e,(async()=>{await this.renderInt(t)}))):b._package.logger.warning(`${e}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const e=t.max-t.min,n=this.canvas.offsetWidth/e-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(T.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(T.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(T.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){if(!this.monomerLib||!this.seqHandler)return;const e=window.devicePixelRatio;try{const n=t,i=this.canvas.getCursorPosition(n,e),[s,a]=this.getMonomer(i,e),l=this.showPositionLabels?12*e:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const t=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.defaultBiotype;t.push(s.buildCompositionTable(e,this.monomerLib))}const e=o.divV(t);e.style.maxHeight="80vh",o.tooltip.show(e,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=s.getFreq(a),e=[o.div(`${a}`),o.div(`${t.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&e.push(o.div(`${this.valueAggrType}: ${t.value.toFixed(3)}`));const i=o.divV(e);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(e,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=r.BitSet.create(this.dataFrame.selection.length,(t=>function(t,e,n,i,o,r){const s=e.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),t,o,i)));this.dataFrame.selection.init((e=>t.get(e)))}}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+e)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`invalidate(${t?` <- ${t} `:""})`,n=`${this.toLog()}.${e}`;this.render(T.None,e),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}},1687:(t,e,n)=>{"use strict";n.d(e,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(4954),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(6723);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(t){super(),this.seqHelper=t,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const t of this.viewSubs)t.unsubscribe()}async attach(){this.viewerToLog();try{const t=await(0,g.b2)();let e,n;this.helmEditor=t.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{e=i.div(),n=t.createWebEditorApp(e,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{try{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(t,void 0,v._package.logger)}catch(t){this.logger.error(t)}finally{f()(e).empty(),e=null,n=null}})).onCancel((()=>{f()(e).empty(),e=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((t=>{try{if(n){const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(t)}}catch(t){const[e,n]=(0,y.AP)(t);this.logger.error(e,void 0,n)}})))}catch(t){const[e,n]=(0,y.AP)(t),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,e)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(t){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=e/2;if(t)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,n);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,t)}}async substructureSearch(t){const e=`${this.viewerToLog()}.substructureSearch( column = <${t.name}> )`;v._package.logger.debug(`${e}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,t,this.seqHelper)}finally{v._package.logger.debug(`${e}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(t,e,n,i,o){this.props=t,this.filterId=e,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class S extends p.n{separator;constructor(t,e,n){super(t,!1,n),this.separator=e,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(t,e){super(),this.seqHelper=t,this.logger=e,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(t){const e=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{e(t),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=t.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new T(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const t=super.detach.bind(this),e=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(e,(async()=>{for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[],t(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(t){t.filterId!==this.filterId&&t.dataFrameId===this.dataFrame.id&&t.columnName===this.columnName&&(this.bioFilter.props=t.props)}applyFilter(){const t=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${t}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=`${this.filterToLog()}.saveState()`,e=super.saveState();return this.logger.debug(`${t}, super.state = ${JSON.stringify(e)}`),e.props=this.bioFilter.saveProps(),e}applyState(t){const e=`${this.filterToLog()}.applyState()`;super.applyState(t),this.filterSyncer.sync(e,(async()=>{t.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(t.props??{}))}))}fireFilterSync(){const t=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${t}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),r.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const t=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${t}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(t,(async()=>{this.calculating=!0;try{this.logger.debug(`${t}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${t}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${t}, end`)}}))}grokEventsOnResetFilterRequest(){const t=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${t}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.filterToLog()}.invalidate(${t?` <- ${t} `:""})`;this.filterSyncer.sync(e,(async()=>{this._onRendered.next()}))}async awaitRendered(t=1e4){const e=`awaitRendered( ${t} )`,n=`${this.filterToLog()}.${e}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(e)}),t,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{window.setTimeout((()=>{this.props=new p.n(t,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(t){return(0,d.nI)(this.props.substructure,t)}async attach(){}async detach(){await super.detach()}}class T extends p.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(t){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{this.props=new S(t,this.props.separator,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=t,onValueChanged:t=>{const e=t||"";this.props=new S(this.props.substructure,e,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const t=this.props.separator??this.colSeparator;this.separatorInput.value!==t&&(this.separatorInput.value=t)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,d.nI)(this.substructure,t,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757:t=>{"use strict";t.exports=$},6082:t=>{"use strict";t.exports=DG},4328:t=>{"use strict";t.exports=grok},1858:t=>{"use strict";t.exports=rxjs},9713:t=>{"use strict";t.exports=rxjs.operators},7389:t=>{"use strict";t.exports=ui},1991:t=>{"use strict";t.exports=wu},8343:(t,e,n)=>{"use strict";const{normalizeIPv6:i,normalizeIPv4:o,removeDotSegments:r,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(t,e,n,i){const o={};return i||(t=p(h(t,n),n),e=p(h(e,n),n)),!(n=n||{}).tolerant&&e.scheme?(o.scheme=e.scheme,o.userinfo=e.userinfo,o.host=e.host,o.port=e.port,o.path=r(e.path||""),o.query=e.query):(void 0!==e.userinfo||void 0!==e.host||void 0!==e.port?(o.userinfo=e.userinfo,o.host=e.host,o.port=e.port,o.path=r(e.path||""),o.query=e.query):(e.path?("/"===e.path.charAt(0)?o.path=r(e.path):(void 0===t.userinfo&&void 0===t.host&&void 0===t.port||t.path?t.path?o.path=t.path.slice(0,t.path.lastIndexOf("/")+1)+e.path:o.path=e.path:o.path="/"+e.path,o.path=r(o.path)),o.query=e.query):(o.path=t.path,void 0!==e.query?o.query=e.query:o.query=t.query),o.userinfo=t.userinfo,o.host=t.host,o.port=t.port),o.scheme=t.scheme),o.fragment=e.fragment,o}function h(t,e){const n={host:t.host,scheme:t.scheme,userinfo:t.userinfo,port:t.port,path:t.path,query:t.query,nid:t.nid,nss:t.nss,uuid:t.uuid,fragment:t.fragment,reference:t.reference,resourceName:t.resourceName,secure:t.secure,error:""},i=Object.assign({},e),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let t=n.path;i.absolutePath||a&&a.absolutePath||(t=r(t)),void 0===c&&(t=t.replace(/^\/\//u,"/%2F")),o.push(t)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const u=Array.from({length:127},((t,e)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(e)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(t,e){const n=Object.assign({},e),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==t.indexOf("%");let a=!1;"suffix"===n.reference&&(t=(n.scheme?n.scheme+":":"")+"//"+t);const c=t.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const t=o(r.host);if(!1===t.isIPV4){const e=i(t.host);r.host=e.host.toLowerCase(),a=e.isIPV6}else r.host=t.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 0===r.fragment?r.reference="absolute":r.reference="uri":r.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==r.reference&&(r.error=r.error||"URI is not a "+n.reference+" reference.");const t=l[(n.scheme||r.scheme||"").toLowerCase()];if(!(n.unicodeSupport||t&&t.unicodeSupport)&&r.host&&(n.domainHost||t&&t.domainHost)&&!1===a&&function(t){let e=0;for(let n=0,i=t.length;n<i;++n)if(e=t.charCodeAt(n),e>126||u[e])return!0;return!1}(r.host))try{r.host=URL.domainToASCII(r.host.toLowerCase())}catch(t){r.error=r.error||"Host's domain name can not be converted to ASCII: "+t}(!t||t&&!t.skipNormalize)&&(s&&void 0!==r.scheme&&(r.scheme=unescape(r.scheme)),s&&void 0!==r.host&&(r.host=unescape(r.host)),r.path&&(r.path=escape(unescape(r.path))),r.fragment&&(r.fragment=encodeURI(decodeURIComponent(r.fragment)))),t&&t.parse&&t.parse(r,n)}else r.error=r.error||"URI can not be parsed.";return r}const m={SCHEMES:l,normalize:function(t,e){return"string"==typeof t?t=h(p(t,e),e):"object"==typeof t&&(t=p(h(t,e),e)),t},resolve:function(t,e,n){const i=Object.assign({scheme:"null"},n);return h(c(p(t,i),p(e,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(t,e,n){return"string"==typeof t?(t=unescape(t),t=h(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=h(a(t,!0),{...n,skipEscape:!0})),"string"==typeof e?(e=unescape(e),e=h(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=h(a(e,!0),{...n,skipEscape:!0})),t.toLowerCase()===e.toLowerCase()},serialize:h,parse:p};t.exports=m,t.exports.default=m,t.exports.fastUri=m},343:t=>{"use strict";const e=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(t){return"boolean"==typeof t.secure?t.secure:"wss"===String(t.scheme).toLowerCase()}function o(t){return t.host||(t.error=t.error||"HTTP URIs must have a host."),t}function r(t){const e="https"===String(t.scheme).toLowerCase();return t.port!==(e?443:80)&&""!==t.port||(t.port=void 0),t.path||(t.path="/"),t}const s={scheme:"http",domainHost:!0,parse:o,serialize:r},a={scheme:"ws",domainHost:!0,parse:function(t){return t.secure=i(t),t.resourceName=(t.path||"/")+(t.query?"?"+t.query:""),t.path=void 0,t.query=void 0,t},serialize:function(t){if(t.port!==(i(t)?443:80)&&""!==t.port||(t.port=void 0),"boolean"==typeof t.secure&&(t.scheme=t.secure?"wss":"ws",t.secure=void 0),t.resourceName){const[e,n]=t.resourceName.split("?");t.path=e&&"/"!==e?e:void 0,t.query=n,t.resourceName=void 0}return t.fragment=void 0,t}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:o,serialize:r},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(t,e){if(!t.path)return t.error="URN can not be parsed",t;const i=t.path.match(n);if(i){const n=e.scheme||t.scheme||"urn";t.nid=i[1].toLowerCase(),t.nss=i[2];const o=`${n}:${e.nid||t.nid}`,r=l[o];t.path=void 0,r&&(t=r.parse(t,e))}else t.error=t.error||"URN can not be parsed.";return t},serialize:function(t,e){const n=e.scheme||t.scheme||"urn",i=t.nid.toLowerCase(),o=`${n}:${e.nid||i}`,r=l[o];r&&(t=r.serialize(t,e));const s=t,a=t.nss;return s.path=`${i||e.nid}:${a}`,e.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(t,n){const i=t;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&e.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(t){const e=t;return e.nss=(t.uuid||"").toLowerCase(),e},skipNormalize:!0}};t.exports=l},4914:t=>{"use strict";t.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(t,e,n)=>{"use strict";const{HEX:i}=n(4914),o=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function r(t){if(c(t,".")<3)return{host:t,isIPV4:!1};const e=t.match(o)||[],[n]=e;return n?{host:l(n,"."),isIPV4:!0}:{host:t,isIPV4:!1}}function s(t,e=!1){let n="",o=!0;for(const e of t){if(void 0===i[e])return;"0"!==e&&!0===o&&(o=!1),o||(n+=e)}return e&&0===n.length&&(n="0"),n}function a(t){if(c(t,":")<2)return{host:t,isIPV6:!1};const e=function(t){let e=0;const n={error:!1,address:"",zone:""},i=[],o=[];let r=!1,a=!1,l=!1;function c(){if(o.length){if(!1===r){const t=s(o);if(void 0===t)return n.error=!0,!1;i.push(t)}o.length=0}return!0}for(let s=0;s<t.length;s++){const h=t[s];if("["!==h&&"]"!==h)if(":"!==h)if("%"===h){if(!c())break;r=!0}else o.push(h);else{if(!0===a&&(l=!0),!c())break;if(e++,i.push(":"),e>7){n.error=!0;break}s-1>=0&&":"===t[s-1]&&(a=!0)}}return o.length&&(r?n.zone=o.join(""):l?i.push(o.join("")):i.push(s(o))),n.address=i.join(""),n}(t);if(e.error)return{host:t,isIPV6:!1};{let t=e.address,n=e.address;return e.zone&&(t+="%"+e.zone,n+="%25"+e.zone),{host:t,escapedHost:n,isIPV6:!0}}}function l(t,e){let n="",i=!0;const o=t.length;for(let r=0;r<o;r++){const s=t[r];"0"===s&&i?(r+1<=o&&t[r+1]===e||r+1===o)&&(n+=s,i=!1):(i=s===e,n+=s)}return n}function c(t,e){let n=0;for(let i=0;i<t.length;i++)t[i]===e&&n++;return n}const h=/^\.\.?\//u,u=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,p=/^\/?(?:.|\n)*?(?=\/|$)/u;t.exports={recomposeAuthority:function(t){const e=[];if(void 0!==t.userinfo&&(e.push(t.userinfo),e.push("@")),void 0!==t.host){let n=unescape(t.host);const i=r(n);if(i.isIPV4)n=i.host;else{const e=a(i.host);n=!0===e.isIPV6?`[${e.escapedHost}]`:t.host}e.push(n)}return"number"!=typeof t.port&&"string"!=typeof t.port||(e.push(":"),e.push(String(t.port))),e.length?e.join(""):void 0},normalizeComponentEncoding:function(t,e){const n=!0!==e?escape:unescape;return void 0!==t.scheme&&(t.scheme=n(t.scheme)),void 0!==t.userinfo&&(t.userinfo=n(t.userinfo)),void 0!==t.host&&(t.host=n(t.host)),void 0!==t.path&&(t.path=n(t.path)),void 0!==t.query&&(t.query=n(t.query)),void 0!==t.fragment&&(t.fragment=n(t.fragment)),t},removeDotSegments:function(t){const e=[];for(;t.length;)if(t.match(h))t=t.replace(h,"");else if(t.match(u))t=t.replace(u,"/");else if(t.match(d))t=t.replace(d,"/"),e.pop();else if("."===t||".."===t)t="";else{const n=t.match(p);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];t=t.slice(i.length),e.push(i)}}return e.join("")},normalizeIPv4:r,normalizeIPv6:a,stringArrayToHexStripped:s}},3837:t=>{"use strict";t.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:t=>{"use strict";t.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},e={};function n(i){var o=e[i];if(void 0!==o)return o.exports;var r=e[i]={id:i,loaded:!1,exports:{}};return t[i].call(r.exports,r,r.exports,n),r.loaded=!0,r.exports}n.m=t,n.amdO={},n.n=t=>{var e=t&&t.__esModule?()=>t.default:()=>t;return n.d(e,{a:e}),e},n.d=(t,e)=>{for(var i in e)n.o(e,i)&&!n.o(t,i)&&Object.defineProperty(t,i,{enumerable:!0,get:e[i]})},n.u=t=>t+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(t){if("object"==typeof window)return window}}(),n.hmd=t=>((t=Object.create(t)).children||(t.children=[]),Object.defineProperty(t,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+t.id)}}),t),n.o=(t,e)=>Object.prototype.hasOwnProperty.call(t,e),n.r=t=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(t,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(t,"__esModule",{value:!0})},(()=>{var t;n.g.importScripts&&(t=n.g.location+"");var e=n.g.document;if(!t&&e&&(e.currentScript&&"SCRIPT"===e.currentScript.tagName.toUpperCase()&&(t=e.currentScript.src),!t)){var i=e.getElementsByTagName("script");if(i.length)for(var o=i.length-1;o>-1&&(!t||!/^http(s?):/.test(t));)t=i[o--].src}if(!t)throw new Error("Automatic publicPath is not supported in this browser");t=t.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=t})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var i=n(6723);bio=i})();
+    depsCount: ${t},
+    deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const i in e)"__proto__"!==i&&((Array.isArray(e[i])?t:n)[i]=e[i]);return[t,n]}(e);a(e,t),l(e,n)}};function a(e,t=e.schema){const{gen:n,data:o,it:s}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const l in t){const c=t[l];if(0===c.length)continue;const u=(0,r.propertyInData)(n,o,l,s.opts.ownProperties);e.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(u,(()=>{for(const t of c)(0,r.checkReportMissingProp)(e,t)})):(n.if(i._`${u} && (${(0,r.checkMissingProp)(e,c,a)})`),(0,r.reportMissingProp)(e,a),n.else())}}function l(e,t=e.schema){const{gen:n,data:i,keyword:s,it:a}=e,l=n.name("valid");for(const c in t)(0,o.alwaysValidSchema)(a,t[c])||(n.if((0,r.propertyInData)(n,i,c,a.opts.ownProperties),(()=>{const t=e.subschema({keyword:s,schemaProp:c},l);e.mergeValidEvaluated(t,l)}),(()=>n.var(l,!0))),e.ok(l))}t.validatePropertyDeps=a,t.validateSchemaDeps=l,t.default=s},4845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,i.validateSchemaDeps)(e)};t.default=o},1239:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>i.str`must match "${e.ifClause}" schema`,params:({params:e})=>i._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:r}=e;void 0===n.then&&void 0===n.else&&(0,o.checkStrictMode)(r,'"if" without "then" and "else" is ignored');const a=s(r,"then"),l=s(r,"else");if(!a&&!l)return;const c=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&l){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,h("then",n),h("else",n))}else a?t.if(u,h("then")):t.if((0,i.not)(u),h("else"));function h(n,o){return()=>{const r=e.subschema({keyword:n},u);t.assign(c,u),e.mergeValidEvaluated(r,c),o?t.assign(o,i._`${n}`):e.setParams({ifClause:n})}}e.pass(c,(()=>e.error(!0)))}};function s(e,t){const n=e.schema[t];return void 0!==n&&!(0,o.alwaysValidSchema)(e,n)}t.default=r},6378:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5457),o=n(5354),r=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(2094),u=n(8660),h=n(117),d=n(5333),p=n(7923),m=n(6505),g=n(6163),f=n(5844),y=n(1239),b=n(4426);t.default=function(e=!1){const t=[p.default,m.default,g.default,f.default,y.default,b.default,c.default,u.default,l.default,h.default,d.default];return e?t.push(o.default,s.default):t.push(i.default,r.default),t.push(a.default),t}},494:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const i=n(9029),o=n(4227),r=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,o.alwaysValidSchema)(n,t)||e.ok((0,r.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:r,parentSchema:s,data:a,keyword:l,it:c}=e;!function(e){const{opts:i,errSchemaPath:r}=c,s=n.length,a=s===e.minItems&&(s===e.maxItems||!1===e[t]);if(i.strictTuples&&!a){const e=`"${l}" is ${s}-tuple, but minItems or maxItems/${t} are not specified or different at path "${r}"`;(0,o.checkStrictMode)(c,e,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=o.mergeEvaluated.items(r,n.length,c.items));const u=r.name("valid"),h=r.const("len",i._`${a}.length`);n.forEach(((t,n)=>{(0,o.alwaysValidSchema)(c,t)||(r.if(i._`${h} > ${n}`,(()=>e.subschema({keyword:l,schemaProp:n,dataProp:n},u))),e.ok(u))}))}t.validateTuple=a,t.default=s},3966:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:i}=e,{prefixItems:a}=n;i.items=!0,(0,o.alwaysValidSchema)(i,t)||(a?(0,s.validateAdditionalItems)(e,a):e.ok((0,r.validateArray)(e)))}};t.default=a},7923:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:o}=e;if((0,i.alwaysValidSchema)(o,n))return void e.fail();const r=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},r),e.failResult(r,(()=>e.reset()),(()=>e.error()))},error:{message:"must NOT be valid"}};t.default=o},6163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>i._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:r,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&r.discriminator)return;const a=n,l=t.let("valid",!1),c=t.let("passing",null),u=t.name("_valid");e.setParams({passing:c}),t.block((function(){a.forEach(((n,r)=>{let a;(0,o.alwaysValidSchema)(s,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:r,compositeRule:!0},u),r>0&&t.if(i._`${u} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${r}]`).else(),t.if(u,(()=>{t.assign(l,!0),t.assign(c,r),a&&e.mergeEvaluated(a,i.Name)}))}))})),e.result(l,(()=>e.reset()),(()=>e.error(!0)))}};t.default=r},5333:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:l,it:c}=e,{opts:u}=c,h=(0,i.allSchemaProperties)(n),d=h.filter((e=>(0,r.alwaysValidSchema)(c,n[e])));if(0===h.length||d.length===h.length&&(!c.opts.unevaluated||!0===c.props))return;const p=u.strictSchema&&!u.allowMatchingProperties&&l.properties,m=t.name("valid");!0===c.props||c.props instanceof o.Name||(c.props=(0,s.evaluatedPropsToName)(t,c.props));const{props:g}=c;function f(e){for(const t in p)new RegExp(e).test(t)&&(0,r.checkStrictMode)(c,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,(r=>{t.if(o._`${(0,i.usePattern)(e,n)}.test(${r})`,(()=>{const i=d.includes(n);i||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:r,dataPropType:s.Type.Str},m),c.opts.unevaluated&&!0!==g?t.assign(o._`${g}[${r}]`,!0):i||c.allErrors||t.if((0,o.not)(m),(()=>t.break()))}))}))}!function(){for(const e of h)p&&f(e),c.allErrors?y(e):(t.var(m,!0),y(e),t.if(m))}()}};t.default=a},5354:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(494),o={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,i.validateTuple)(e,"items")};t.default=o},117:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2586),o=n(5765),r=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const u=(0,o.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=r.mergeEvaluated.props(t,(0,r.toHash)(u),c.props));const h=u.filter((e=>!(0,r.alwaysValidSchema)(c,n[e])));if(0===h.length)return;const d=t.name("valid");for(const n of h)p(n)?m(n):(t.if((0,o.propertyInData)(t,l,n,c.opts.ownProperties)),m(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function p(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function m(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},2094:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>i._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:r,it:s}=e;if((0,o.alwaysValidSchema)(s,n))return;const a=t.name("valid");t.forIn("key",r,(n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,i.not)(a),(()=>{e.error(!0),s.allErrors||t.break()}))})),e.ok(a)}};t.default=r},4426:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,i.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=o},5765:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const i=n(9029),o=n(4227),r=n(2023),s=n(4227);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(e,t,n){return i._`${a(e)}.call(${t}, ${n})`}function c(e,t,n,o){const r=i._`${t}${(0,i.getProperty)(n)} === undefined`;return o?(0,i.or)(r,(0,i.not)(l(e,t,n))):r}function u(e){return e?Object.keys(e).filter((e=>"__proto__"!==e)):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:o,it:r}=e;n.if(c(n,o,t,r.opts.ownProperties),(()=>{e.setParams({missingProperty:i._`${t}`},!0),e.error()}))},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},o,r){return(0,i.or)(...o.map((o=>(0,i.and)(c(e,t,o,n.ownProperties),i._`${r} = ${o}`))))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=l,t.propertyInData=function(e,t,n,o){const r=i._`${t}${(0,i.getProperty)(n)} !== undefined`;return o?i._`${r} && ${l(e,t,n)}`:r},t.noPropertyInData=c,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter((n=>!(0,o.alwaysValidSchema)(e,t[n])))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:o,schemaPath:s,errorPath:a},it:l},c,u,h){const d=h?i._`${e}, ${t}, ${o}${s}`:t,p=[[r.default.instancePath,(0,i.strConcat)(r.default.instancePath,a)],[r.default.parentData,l.parentData],[r.default.parentDataProperty,l.parentDataProperty],[r.default.rootData,r.default.rootData]];l.opts.dynamicRef&&p.push([r.default.dynamicAnchors,r.default.dynamicAnchors]);const m=i._`${d}, ${n.object(...p)}`;return u!==i.nil?i._`${c}.call(${u}, ${m})`:i._`${c}(${m})`};const h=i._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const o=t.unicodeRegExp?"u":"",{regExp:r}=t.code,a=r(n,o);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===r.code?h:(0,s.useFunc)(e,r)}(${n}, ${o})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:r,it:s}=e,a=t.name("valid");if(s.allErrors){const e=t.let("valid",!0);return l((()=>t.assign(e,!1))),e}return t.var(a,!0),l((()=>t.break())),a;function l(s){const l=t.const("len",i._`${n}.length`);t.forRange("i",0,l,(n=>{e.subschema({keyword:r,dataProp:n,dataPropType:o.Type.Num},a),t.if((0,i.not)(a),s)}))}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:r,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((e=>(0,o.alwaysValidSchema)(s,e)))&&!s.opts.unevaluated)return;const a=t.let("valid",!1),l=t.name("_valid");t.block((()=>n.forEach(((n,o)=>{const s=e.subschema({keyword:r,schemaProp:o,compositeRule:!0},l);t.assign(a,i._`${a} || ${l}`),e.mergeValidEvaluated(s,l)||t.if((0,i.not)(a))})))),e.result(a,(()=>e.reset()),(()=>e.error(!0)))}},3463:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},2128:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3463),o=n(3693),r=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,o.default];t.default=r},3693:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const i=n(4551),o=n(5765),r=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:o}=e,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:p}=o,{root:m}=l;if(("#"===n||"#/"===n)&&s===m.baseId)return function(){if(l===m)return h(e,c,l,l.$async);const n=t.scopeValue("root",{ref:m});return h(e,r._`${n}.validate`,m,m.$async)}();const g=a.resolveRef.call(p,m,s,n);if(void 0===g)throw new i.default(o.opts.uriResolver,s,n);return g instanceof a.SchemaEnv?function(t){const n=u(e,t);h(e,n,t,t.$async)}(g):function(i){const o=t.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,r.stringify)(i)}:{ref:i}),s=t.name("valid"),a=e.subschema({schema:i,dataTypes:[],schemaPath:r.nil,topSchemaRef:o,errSchemaPath:n},s);e.mergeEvaluated(a),e.ok(s)}(g)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):r._`${n.scopeValue("wrapper",{ref:t})}.validate`}function h(e,t,n,i){const{gen:a,it:c}=e,{allErrors:u,schemaEnv:h,opts:d}=c,p=d.passContext?s.default.this:r.nil;function m(e){const t=r._`${e}.errors`;a.assign(s.default.vErrors,r._`${s.default.vErrors} === null ? ${t} : ${s.default.vErrors}.concat(${t})`),a.assign(s.default.errors,r._`${s.default.vErrors}.length`)}function g(e){var t;if(!c.opts.unevaluated)return;const i=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const t=a.var("props",r._`${e}.evaluated.props`);c.props=l.mergeEvaluated.props(a,t,c.props,r.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const t=a.var("items",r._`${e}.evaluated.items`);c.items=l.mergeEvaluated.items(a,t,c.items,r.Name)}}i?function(){if(!h.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(r._`await ${(0,o.callValidateCode)(e,t,p)}`),g(t),u||a.assign(n,!0)}),(e=>{a.if(r._`!(${e} instanceof ${c.ValidationError})`,(()=>a.throw(e))),m(e),u||a.assign(n,!1)})),e.ok(n)}():e.result((0,o.callValidateCode)(e,t,p),(()=>g(t)),(()=>m(t)))}t.getValidate=u,t.callRef=h,t.default=c},6653:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(7652),r=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===o.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>i._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:l,parentSchema:c,it:u}=e,{oneOf:h}=c;if(!u.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!h)throw new Error("discriminator: requires oneOf keyword");const p=t.let("valid",!1),m=t.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function g(n){const o=t.name("valid"),r=e.subschema({keyword:"oneOf",schemaProp:n},o);return e.mergeEvaluated(r,i.Name),o}t.if(i._`typeof ${m} == "string"`,(()=>function(){const n=function(){var e;const t={},n=o(c);let i=!0;for(let t=0;t<h.length;t++){let c=h[t];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,u.self.RULES)){const e=c.$ref;if(c=r.resolveRef.call(u.self,u.schemaEnv.root,u.baseId,e),c instanceof r.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(u.opts.uriResolver,u.baseId,e)}const p=null===(e=null==c?void 0:c.properties)||void 0===e?void 0:e[d];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||o(c)),l(p,t)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return t;function o({required:e}){return Array.isArray(e)&&e.includes(d)}function l(e,t){if(e.const)p(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of e.enum)p(n,t)}}function p(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${d}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(i._`${m} === ${e}`),t.assign(p,g(n[e]));t.else(),e.error(!1,{discrError:o.DiscrError.Mapping,tag:m,tagName:d}),t.endIf()}()),(()=>e.error(!1,{discrError:o.DiscrError.Tag,tag:m,tagName:d}))),e.ok(p)}};t.default=l},7652:(e,t)=>{"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,function(e){e.Tag="tag",e.Mapping="mapping"}(n||(t.DiscrError=n={}))},6105:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),u=n(9857),h=[s.default,i.default,o.default,(0,r.default)(!0),c.default,u.metadataVocabulary,u.contentVocabulary,a.default,l.default];t.default=h},6144:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(7532),a=n(9857),l=[i.default,o.default,(0,r.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];t.default=l},2476:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const i=n(9029),o=n(2023),r=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>l(e,e.schema)};function l(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const l=i._`${o.default.dynamicAnchors}${(0,i.getProperty)(t)}`,c="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:i}=e.it,{root:o,baseId:a,localRefs:l,meta:c}=t.root,{schemaId:u}=i.opts,h=new r.SchemaEnv({schema:n,schemaId:u,root:o,baseId:a,localRefs:l,meta:c});return r.compileSchema.call(i,h),(0,s.getValidate)(e,h)}(e);n.if(i._`!${l}`,(()=>n.assign(l,c)))}t.dynamicAnchor=l,t.default=a},3252:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const i=n(9029),o=n(2023),r=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:s,it:a}=e;if("#"!==t[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=t.slice(1);if(a.allErrors)c();else{const t=n.let("valid",!1);c(t),e.ok(t)}function c(e){if(a.schemaEnv.root.dynamicAnchors[l]){const t=n.let("_v",i._`${o.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,i){return i?()=>n.block((()=>{(0,r.callRef)(e,t),n.let(i,!0)})):()=>(0,r.callRef)(e,t)}}t.dynamicRef=a,t.default=s},5520:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),o=n(3252),r=n(2721),s=n(3799),a=[i.default,o.default,r.default,s.default];t.default=a},2721:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),o=n(4227),r={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,i.dynamicAnchor)(e,""):(0,o.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=r},3799:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3252),o={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,i.dynamicRef)(e,e.schema)};t.default=o},4737:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>i.str`must match format "${e}"`,params:({schemaCode:e})=>i._`{format: ${e}}`},code(e,t){const{gen:n,data:o,$data:r,schema:s,schemaCode:a,it:l}=e,{opts:c,errSchemaPath:u,schemaEnv:h,self:d}=l;c.validateFormats&&(r?function(){const r=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${r}[${a}]`),l=n.let("fType"),u=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,(()=>n.assign(l,i._`${s}.type || "string"`).assign(u,i._`${s}.validate`)),(()=>n.assign(l,i._`"string"`).assign(u,s))),e.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${u}`,function(){const e=h.$async?i._`(${s}.async ? await ${u}(${o}) : ${u}(${o}))`:i._`${u}(${o})`,n=i._`(typeof ${u} == "function" ? ${e} : ${u}.test(${o}))`;return i._`${u} && ${u} !== true && ${l} === ${t} && !${n}`}()))}():function(){const r=d.formats[s];if(!r)return void function(){if(!1!==c.strictSchema)throw new Error(e());function e(){return`unknown format "${s}" ignored in schema at path "${u}"`}d.logger.warn(e())}();if(!0===r)return;const[a,l,p]=function(e){const t=e instanceof RegExp?(0,i.regexpCode)(e):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,o=n.scopeValue("formats",{key:s,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,o]:[e.type||"string",e.validate,i._`${o}.validate`]}(r);a===t&&e.pass(function(){if("object"==typeof r&&!(r instanceof RegExp)&&r.async){if(!h.$async)throw new Error("async format in sync schema");return i._`await ${p}(${o})`}return"function"==typeof l?i._`${p}(${o})`:i._`${p}.test(${o})`}())}())}};t.default=o},7532:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=[n(4737).default];t.default=i},9857:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1846),o=n(4845),r=n(2626),s=[i.default,o.default,r.default];t.default=s},3265:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(392),o=n(3445),r=[i.default,o.default];t.default=r},3445:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:r,it:s}=e,a=s.items||0;if(!0===a)return;const l=t.const("len",i._`${r}.length`);if(!1===n)e.setParams({len:a}),e.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,o.alwaysValidSchema)(s,n)){const n=t.var("valid",i._`${l} <= ${a}`);t.if((0,i.not)(n),(()=>function(n,r){t.forRange("i",r,l,(r=>{e.subschema({keyword:"unevaluatedItems",dataProp:r,dataPropType:o.Type.Num},n),s.allErrors||t.if((0,i.not)(n),(()=>t.break()))}))}(n,a))),e.ok(n)}s.items=!0}};t.default=r},392:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>i._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:s,errsCount:a,it:l}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:u}=l;function h(r){if(!1===n)return e.setParams({unevaluatedProperty:r}),e.error(),void(c||t.break());if(!(0,o.alwaysValidSchema)(l,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:r,dataPropType:o.Type.Str},n),c||t.if((0,i.not)(n),(()=>t.break()))}}u instanceof i.Name?t.if(i._`${u} !== true`,(()=>t.forIn("key",s,(e=>t.if(function(e,t){return i._`!${e} || !${e}[${t}]`}(u,e),(()=>h(e))))))):!0!==u&&t.forIn("key",s,(e=>void 0===u?h(e):t.if(function(e,t){const n=[];for(const o in e)!0===e[o]&&n.push(i._`${t} !== ${o}`);return(0,i.and)(...n)}(u,e),(()=>h(e))))),l.props=!0,e.ok(i._`${a} === ${r.default.errors}`)}};t.default=s},7935:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>i._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:s,schemaCode:a,schema:l}=e;s||l&&"object"==typeof l?e.fail$data(i._`!${(0,o.useFunc)(t,r.default)}(${n}, ${a})`):e.fail(i._`${l} !== ${n}`)}};t.default=s},1846:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:e=>(0,i.validatePropertyDeps)(e)};t.default=o},8643:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>i._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:s,schema:a,schemaCode:l,it:c}=e;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=c.opts.loopEnum;let h;const d=()=>null!=h?h:h=(0,o.useFunc)(t,r.default);let p;if(u||s)p=t.let("valid"),e.block$data(p,(function(){t.assign(p,!1),t.forOf("v",l,(e=>t.if(i._`${d()}(${n}, ${e})`,(()=>t.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",l);p=(0,i.or)(...a.map(((t,o)=>function(e,t){const o=a[t];return"object"==typeof o&&null!==o?i._`${d()}(${n}, ${e}[${t}])`:i._`${n} === ${o}`}(e,o))))}e.pass(p)}};t.default=s},7060:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5882),o=n(3439),r=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),u=n(617),h=n(7935),d=n(8643),p=[i.default,o.default,r.default,s.default,a.default,l.default,c.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},h.default,d.default];t.default=p},2626:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,i.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=o},1163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o}=e,r="maxItems"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`${n}.length ${r} ${o}`)}};t.default=o},7307:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:s,it:a}=e,l="maxLength"===t?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,o.useFunc)(e.gen,r.default)}(${n})`;e.fail$data(i._`${c} ${l} ${s}`)}};t.default=s},5882:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=i.operators,r={maximum:{okStr:"<=",ok:o.LTE,fail:o.GT},minimum:{okStr:">=",ok:o.GTE,fail:o.LT},exclusiveMaximum:{okStr:"<",ok:o.LT,fail:o.GTE},exclusiveMinimum:{okStr:">",ok:o.GT,fail:o.LTE}},s={message:({keyword:e,schemaCode:t})=>i.str`must be ${r[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>i._`{comparison: ${r[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(r),type:"number",schemaType:"number",$data:!0,error:s,code(e){const{keyword:t,data:n,schemaCode:o}=e;e.fail$data(i._`${n} ${r[t].fail} ${o} || isNaN(${n})`)}};t.default=a},4486:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o}=e,r="maxProperties"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`Object.keys(${n}).length ${r} ${o}`)}};t.default=o},3439:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>i.str`must be multiple of ${e}`,params:({schemaCode:e})=>i._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:o,it:r}=e,s=r.opts.multipleOfPrecision,a=t.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;e.fail$data(i._`(${o} === 0 || (${a} = ${n}/${o}, ${l}))`)}};t.default=o},422:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>o.str`must match pattern "${e}"`,params:({schemaCode:e})=>o._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:r,schemaCode:s,it:a}=e,l=a.opts.unicodeRegExp?"u":"",c=n?o._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(e,r);e.fail$data(o._`!${c}.test(${t})`)}};t.default=r},4003:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>o.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>o._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:s,data:a,$data:l,it:c}=e,{opts:u}=c;if(!l&&0===n.length)return;const h=n.length>=u.loopRequired;if(c.allErrors?function(){if(h||l)e.block$data(o.nil,d);else for(const t of n)(0,i.checkReportMissingProp)(e,t)}():function(){const r=t.let("missing");if(h||l){const n=t.let("valid",!0);e.block$data(n,(()=>function(n,r){e.setParams({missingProperty:n}),t.forOf(n,s,(()=>{t.assign(r,(0,i.propertyInData)(t,a,n,u.ownProperties)),t.if((0,o.not)(r),(()=>{e.error(),t.break()}))}),o.nil)}(r,n))),e.ok(n)}else t.if((0,i.checkMissingProp)(e,n,r)),(0,i.reportMissingProp)(e,r),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:i}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!i.has(e)){const t=`required property "${e}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,r.checkStrictMode)(c,t,c.opts.strictRequired)}}function d(){t.forOf("prop",s,(n=>{e.setParams({missingProperty:n}),t.if((0,i.noPropertyInData)(t,a,n,u.ownProperties),(()=>e.error()))}))}}};t.default=s},617:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(208),o=n(9029),r=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>o.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>o._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:l,parentSchema:c,schemaCode:u,it:h}=e;if(!a&&!l)return;const d=t.let("valid"),p=c.items?(0,i.getSchemaTypes)(c.items):[];function m(r,s){const a=t.name("item"),l=(0,i.checkDataTypes)(p,a,h.opts.strictNumbers,i.DataType.Wrong),c=t.const("indices",o._`{}`);t.for(o._`;${r}--;`,(()=>{t.let(a,o._`${n}[${r}]`),t.if(l,o._`continue`),p.length>1&&t.if(o._`typeof ${a} == "string"`,o._`${a} += "_"`),t.if(o._`typeof ${c}[${a}] == "number"`,(()=>{t.assign(s,o._`${c}[${a}]`),e.error(),t.assign(d,!1).break()})).code(o._`${c}[${a}] = ${r}`)}))}function g(i,a){const l=(0,r.useFunc)(t,s.default),c=t.name("outer");t.label(c).for(o._`;${i}--;`,(()=>t.for(o._`${a} = ${i}; ${a}--;`,(()=>t.if(o._`${l}(${n}[${i}], ${n}[${a}])`,(()=>{e.error(),t.assign(d,!1).break(c)}))))))}e.block$data(d,(function(){const i=t.let("i",o._`${n}.length`),r=t.let("j");e.setParams({i,j:r}),t.assign(d,!0),t.if(o._`${i} > 1`,(()=>(p.length>0&&!p.some((e=>"object"===e||"array"===e))?m:g)(i,r)))}),o._`${u} === false`),e.ok(d)}};t.default=a},5488:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}"],sourceRoot:""}]);const a=s},857:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB;;AAEA;IACI,qBAAqB;AACzB;;AAEA;IACI,4BAA4B;AAChC",sourcesContent:[".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}"],sourceRoot:""}]);const a=s},6369:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,WAAW;AACf;;AAEA;IACI,4BAA4B;IAC5B,yBAAyB;IACzB,eAAe;AACnB;;AAEA;GACG,mBAAmB;AACtB;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,gBAAgB;EAChB,WAAW;;AAEb",sourcesContent:[".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n"],sourceRoot:""}]);const a=s},6314:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n="",i=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),i&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),i&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n})).join("")},t.i=function(e,n,i,o,r){"string"==typeof e&&(e=[[null,e,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<e.length;c++){var u=[].concat(e[c]);i&&s[u[0]]||(void 0!==r&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=r),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),o&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=o):u[4]="".concat(o)),t.push(u))}},t}},1354:e=>{"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),o="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),r="/*# ".concat(o," */");return[t].concat([r]).join("\n")}return[t].join("\n")}},2017:e=>{"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var i,o,r;if(Array.isArray(t)){if((i=t.length)!=n.length)return!1;for(o=i;0!=o--;)if(!e(t[o],n[o]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((i=(r=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(o=i;0!=o--;)if(!Object.prototype.hasOwnProperty.call(n,r[o]))return!1;for(o=i;0!=o--;){var s=r[o];if(!e(t[s],n[s]))return!1}return!0}return t!=t&&n!=n}},9982:function(e,t,n){var i;!function(){var t={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,i,o,r){for(var s,a,l,c,u,h,d,p,m,g,f,y,b;r>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],u=n[4],h=n[5],d=n[6],p=n[7],g=0;g<16;g++)f=o+4*g,e[g]=(255&i[f])<<24|(255&i[f+1])<<16|(255&i[f+2])<<8|255&i[f+3];for(g=16;g<64;g++)y=((m=e[g-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,b=((m=e[g-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,e[g]=(y+e[g-7]|0)+(b+e[g-16]|0);for(g=0;g<64;g++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&h^~u&d)|0)+(p+(t[g]+e[g]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,p=d,d=h,h=u,u=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=u,n[5]+=h,n[6]+=d,n[7]+=p,o+=64,r-=64}return o}var i=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[i++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(i=n(this.temp,this.state,e,i,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[i++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,i=this.bufferLength,o=t/536870912|0,r=t<<3,s=t%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=o>>>24&255,this.buffer[s-7]=o>>>16&255,this.buffer[s-6]=o>>>8&255,this.buffer[s-5]=o>>>0&255,this.buffer[s-4]=r>>>24&255,this.buffer[s-3]=r>>>16&255,this.buffer[s-2]=r>>>8&255,this.buffer[s-1]=r>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=i;var o=function(){function e(e){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new i).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function r(e){var t=(new i).update(e),n=t.digest();return t.clean(),n}function s(e,t){var n=new o(e).update(t),i=n.digest();return n.clean(),i}function a(e,t,n,i){var o=i[0];if(0===o)throw new Error("hkdf: cannot expand more");t.reset(),o>1&&t.update(e),n&&t.update(n),t.update(i),t.finish(e),i[0]++}e.HMAC=o,e.hash=r,e.default=r,e.hmac=s;var l=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,i){void 0===t&&(t=l),void 0===i&&(i=32);for(var r=new Uint8Array([1]),c=s(t,e),u=new o(c),h=new Uint8Array(u.digestLength),d=h.length,p=new Uint8Array(i),m=0;m<i;m++)d===h.length&&(a(h,u,n,r),d=0),p[m]=h[d++];return u.clean(),h.fill(0),r.fill(0),p},e.pbkdf2=function(e,t,n,i){for(var r=new o(e),s=r.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),u=new Uint8Array(i),h=0;h*s<i;h++){var d=h+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,r.reset(),r.update(t),r.update(a),r.finish(c);for(var p=0;p<s;p++)l[p]=c[p];for(p=2;p<=n;p++){r.reset(),r.update(c).finish(c);for(var m=0;m<s;m++)l[m]^=c[m]}for(p=0;p<s&&h*s+p<i;p++)u[h*s+p]=l[p]}for(h=0;h<s;h++)l[h]=c[h]=0;for(h=0;h<4;h++)a[h]=0;return r.clean(),u}}(t);var o=t.default;for(var r in t)o[r]=t[r];"object"==typeof e.exports?e.exports=o:void 0===(i=function(){return o}.call(t,n,t,e))||(e.exports=i)}()},2787:(e,t,n)=>{"use strict";n.d(t,{I:()=>o});const i=new Uint32Array(65536),o=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,o=t.length,r=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[e.charCodeAt(c)]|=1<<c;for(c=0;c<o;c++){let e=i[t.charCodeAt(c)];const n=e|a;e|=(e&s)+s^s,a|=~(e|s),s&=e,a&r&&l++,s&r&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[e.charCodeAt(c)]=0;return l})(e,t):((e,t)=>{const n=t.length,o=e.length,r=[],s=[],a=Math.ceil(n/32),l=Math.ceil(o/32);for(let e=0;e<a;e++)s[e]=-1,r[e]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const u=32*c,h=Math.min(32,o)+u;for(let t=u;t<h;t++)i[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],o=s[e/32|0]>>>e&1,c=r[e/32|0]>>>e&1,u=n|a,h=((n|c)&l)+l^l|n|c;let d=a|~(h|l),p=l&h;d>>>31^o&&(s[e/32|0]^=1<<e),p>>>31^c&&(r[e/32|0]^=1<<e),d=d<<1|o,p=p<<1|c,l=p|~(u|d),a=d&u}for(let t=u;t<h;t++)i[e.charCodeAt(t)]=0}let u=0,h=-1;const d=32*c,p=Math.min(32,o-d)+d;for(let t=d;t<p;t++)i[e.charCodeAt(t)]|=1<<t;let m=o;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],a=s[e/32|0]>>>e&1,l=r[e/32|0]>>>e&1,c=n|u,d=((n|l)&h)+h^h|n|l;let p=u|~(d|h),g=h&d;m+=p>>>o-1&1,m-=g>>>o-1&1,p>>>31^a&&(s[e/32|0]^=1<<e),g>>>31^l&&(r[e/32|0]^=1<<e),p=p<<1|a,g=g<<1|l,h=g|~(c|p),u=p&c}for(let t=d;t<p;t++)i[e.charCodeAt(t)]=0;return m})(e,t)}},9937:e=>{e.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(e,t)=>{t.assign=function(e){e=e||{};var t,n,i,o=Array.prototype.slice.call(arguments).slice(1);for(t=0,i=o.length;t<i;t++)if(o[t])for(n in o[t])e[n]=o[t][n];return e},t.validateSettings=function(e){return"linLogMode"in e&&"boolean"!=typeof e.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in e&&"boolean"!=typeof e.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in e&&"boolean"!=typeof e.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in e&&"number"!=typeof e.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in e)||"number"==typeof e.scalingRatio&&e.scalingRatio>=0?"strongGravityMode"in e&&"boolean"!=typeof e.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in e)||"number"==typeof e.gravity&&e.gravity>=0?"slowDown"in e&&!("number"==typeof e.slowDown||e.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in e&&"boolean"!=typeof e.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in e)||"number"==typeof e.barnesHutTheta&&e.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},t.graphToByteArrays=function(e,t){var n,i=e.order,o=e.size,r={},s=new Float32Array(10*i),a=new Float32Array(3*o);return n=0,e.forEachNode((function(e,t){r[e]=n,s[n]=t.x,s[n+1]=t.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=t.size||1,s[n+9]=t.fixed?1:0,n+=10})),n=0,e.forEachEdge((function(e,i,o,l,c,u,h){var d=r[o],p=r[l],m=t(e,i,o,l,c,u,h);s[d+6]+=m,s[p+6]+=m,a[n]=d,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:s,edges:a}},t.assignLayoutChanges=function(e,t,n){var i=0;e.updateEachNodeAttributes((function(e,o){return o.x=t[i],o.y=t[i+1],i+=10,n?n(e,o):o}))},t.readGraphPositions=function(e,t){var n=0;e.forEachNode((function(e,i){t[n]=i.x,t[n+1]=i.y,n+=10}))},t.collectLayoutChanges=function(e,t,n){for(var i=e.nodes(),o={},r=0,s=0,a=t.length;r<a;r+=10){if(n){var l=Object.assign({},e.getNodeAttributes(i[s]));l.x=t[r],l.y=t[r+1],l=n(i[s],l),o[i[s]]={x:l.x,y:l.y}}else o[i[s]]={x:t[r],y:t[r+1]};s++}return o},t.createWorker=function(e){var t=window.URL||window.webkitURL,n=e.toString(),i=t.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),o=new Worker(i);return t.revokeObjectURL(i),o}},8903:(e,t,n)=>{var i=n(1736),o=n(8153).Fd,r=n(2561),s=n(1782),a=n(9937);function l(e,t,n){if(!i(t))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=o("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,u="function"==typeof n.outputReducer?n.outputReducer:null,h=s.assign({},a,n.settings),d=s.validateSettings(h);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var p,m=s.graphToByteArrays(t,c);for(p=0;p<l;p++)r(h,m.nodes,m.edges);if(!e)return s.collectLayoutChanges(t,m.nodes);s.assignLayoutChanges(t,m.nodes,u)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(e){var t="number"==typeof e?e:e.order;return{barnesHutOptimize:t>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(t)}},e.exports=c},2561:e=>{var t=10;e.exports=function(e,n,i){var o,r,s,a,l,c,u,h,d,p,m,g,f,y,b,v,w,C,S,A,x,M,E,T=n.length,_=i.length,I=e.adjustSizes,L=e.barnesHutTheta*e.barnesHutTheta,N=[];for(s=0;s<T;s+=t)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(e.outboundAttractionDistribution){for(m=0,s=0;s<T;s+=t)m+=n[s+6];m/=T/t}if(e.barnesHutOptimize){var P,R,$,O=1/0,k=-1/0,H=1/0,F=-1/0;for(s=0;s<T;s+=t)O=Math.min(O,n[s+0]),k=Math.max(k,n[s+0]),H=Math.min(H,n[s+1]),F=Math.max(F,n[s+1]);var G=k-O,B=F-H;for(G>B?F=(H-=(G-B)/2)+G:k=(O-=(B-G)/2)+B,N[0]=-1,N[1]=(O+k)/2,N[2]=(H+F)/2,N[3]=Math.max(k-O,F-H),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,o=1,s=0;s<T;s+=t)for(r=0,$=3;;){if(!(N[r+5]>=0)){if(N[r+0]<0){N[r+0]=s;break}if(N[r+5]=9*o,h=N[r+3]/2,N[(d=N[r+5])+0]=-1,N[d+1]=N[r+1]-h,N[d+2]=N[r+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]-h,N[d+2]=N[r+2]+h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+h,N[d+2]=N[r+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+h,N[d+2]=N[r+2]+h,N[d+3]=h,N[d+4]=N[r+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,o+=4,P=n[N[r+0]+0]<N[r+1]?n[N[r+0]+1]<N[r+2]?N[r+5]:N[r+5]+9:n[N[r+0]+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+6]=n[N[r+0]+6],N[r+7]=n[N[r+0]+0],N[r+8]=n[N[r+0]+1],N[P+0]=N[r+0],N[r+0]=-1,P===(R=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27)){if($--){r=P;continue}$=3;break}N[R+0]=s;break}P=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+7]=(N[r+7]*N[r+6]+n[s+0]*n[s+6])/(N[r+6]+n[s+6]),N[r+8]=(N[r+8]*N[r+6]+n[s+1]*n[s+6])/(N[r+6]+n[s+6]),N[r+6]+=n[s+6],r=P}}if(e.barnesHutOptimize){for(g=e.scalingRatio,s=0;s<T;s+=t)for(r=0;;)if(N[r+5]>=0){if(v=Math.pow(n[s+0]-N[r+7],2)+Math.pow(n[s+1]-N[r+8],2),4*(p=N[r+3])*p/v<L){if(f=n[s+0]-N[r+7],y=n[s+1]-N[r+8],!0===I?v>0?(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*N[r+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w),(r=N[r+4])<0)break;continue}r=N[r+5]}else if((c=N[r+0])>=0&&c!==s&&(v=(f=n[s+0]-n[c+0])*f+(y=n[s+1]-n[c+1])*y,!0===I?v>0?(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w)),(r=N[r+4])<0)break}else for(g=e.scalingRatio,a=0;a<T;a+=t)for(l=0;l<a;l+=t)f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8])>0?(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):v<0&&(w=100*g*n[a+6]*n[l+6],n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):(v=Math.sqrt(f*f+y*y))>0&&(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);for(d=e.gravity/e.scalingRatio,g=e.scalingRatio,s=0;s<T;s+=t)w=0,f=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.strongGravityMode?v>0&&(w=g*n[s+6]*d):v>0&&(w=g*n[s+6]*d/v),n[s+2]-=f*w,n[s+3]-=y*w;for(g=1*(e.outboundAttractionDistribution?m:1),u=0;u<_;u+=3)a=i[u+0],l=i[u+1],h=i[u+2],b=Math.pow(h,e.edgeWeightInfluence),f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8],e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?v>0&&(w=-g*b/n[a+6]):v>0&&(w=-g*b)):(v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?(v=1,w=-g*b/n[a+6]):(v=1,w=-g*b)),v>0&&(n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);if(!0===I)for(s=0;s<T;s+=t)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),S=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),A=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+A)/(1+Math.sqrt(S)),M=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=M,E=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=E);else for(s=0;s<T;s+=t)1!==n[s+9]&&(S=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),A=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+A)/(1+Math.sqrt(S)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(S)))),M=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=M,E=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=E);return{}}},8153:(e,t)=>{function n(e){return"number"!=typeof e||isNaN(e)?1:e}t.Fd=function(e){return function(e,t){var n={},i=function(e){return void 0===e?t:e};"function"==typeof t&&(i=t);var o=function(t){return i(t[e])},r=function(){return i(void 0)};return"string"==typeof e?(n.fromAttributes=o,n.fromGraph=function(e,t){return o(e.getEdgeAttributes(t))},n.fromEntry=function(e,t){return o(t)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof e?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(t,n){var o=t.extremities(n);return i(e(n,t.getEdgeAttributes(n),o[0],o[1],t.getNodeAttributes(o[0]),t.getNodeAttributes(o[1]),t.isUndirected(n)))},n.fromEntry=function(t,n,o,r,s,a,l){return i(e(t,n,o,r,s,a,l))},n.fromPartialEntry=function(t,n,o,r){return i(e(t,n,o,r))},n.fromMinimalEntry=function(t,n){return i(e(t,n))}):(n.fromAttributes=r,n.fromGraph=r,n.fromEntry=r,n.fromMinimalEntry=r),n}(e,n)}},1736:e=>{e.exports=function(e){return null!==e&&"object"==typeof e&&"function"==typeof e.addUndirectedEdgeWithKey&&"function"==typeof e.dropNode&&"boolean"==typeof e.multi}},934:function(e){e.exports=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,i(e,t)}function n(e){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(e){return e.__proto__||Object.getPrototypeOf(e)},n(e)}function i(e,t){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(e,t){return e.__proto__=t,e},i(e,t)}function o(e,t,n){return o=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(e){return!1}}()?Reflect.construct.bind():function(e,t,n){var o=[null];o.push.apply(o,t);var r=new(Function.bind.apply(e,o));return n&&i(r,n.prototype),r},o.apply(null,arguments)}function r(e){var t="function"==typeof Map?new Map:void 0;return r=function(e){if(null===e||(r=e,-1===Function.toString.call(r).indexOf("[native code]")))return e;var r;if("function"!=typeof e)throw new TypeError("Super expression must either be null or a function");if(void 0!==t){if(t.has(e))return t.get(e);t.set(e,s)}function s(){return o(e,arguments,n(this).constructor)}return s.prototype=Object.create(e.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,e)},r(e)}function s(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}var a=function(){for(var e=arguments[0],t=1,n=arguments.length;t<n;t++)if(arguments[t])for(var i in arguments[t])e[i]=arguments[t][i];return e};function l(e,t,n,i){var o=e._nodes.get(t),r=null;return o?r="mixed"===i?o.out&&o.out[n]||o.undirected&&o.undirected[n]:"directed"===i?o.out&&o.out[n]:o.undirected&&o.undirected[n]:r}function c(t){return"object"===e(t)&&null!==t}function u(e){var t;for(t in e)return!1;return!0}function h(e,t,n){Object.defineProperty(e,t,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(e,t,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(e,t,i)}function p(e){return!(!c(e)||e.attributes&&!Array.isArray(e.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,g={exports:{}},f="object"==typeof Reflect?Reflect:null,y=f&&"function"==typeof f.apply?f.apply:function(e,t,n){return Function.prototype.apply.call(e,t,n)};m=f&&"function"==typeof f.ownKeys?f.ownKeys:Object.getOwnPropertySymbols?function(e){return Object.getOwnPropertyNames(e).concat(Object.getOwnPropertySymbols(e))}:function(e){return Object.getOwnPropertyNames(e)};var b=Number.isNaN||function(e){return e!=e};function v(){v.init.call(this)}g.exports=v,g.exports.once=function(e,t){return new Promise((function(n,i){function o(n){e.removeListener(t,r),i(n)}function r(){"function"==typeof e.removeListener&&e.removeListener("error",o),n([].slice.call(arguments))}I(e,t,r,{once:!0}),"error"!==t&&function(e,t){"function"==typeof e.on&&I(e,"error",t,{once:!0})}(e,o)}))},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(e){if("function"!=typeof e)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof e)}function S(e){return void 0===e._maxListeners?v.defaultMaxListeners:e._maxListeners}function A(e,t,n,i){var o,r,s,a;if(C(n),void 0===(r=e._events)?(r=e._events=Object.create(null),e._eventsCount=0):(void 0!==r.newListener&&(e.emit("newListener",t,n.listener?n.listener:n),r=e._events),s=r[t]),void 0===s)s=r[t]=n,++e._eventsCount;else if("function"==typeof s?s=r[t]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(o=S(e))>0&&s.length>o&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(t)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=e,l.type=t,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return e}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function M(e,t,n){var i={fired:!1,wrapFn:void 0,target:e,type:t,listener:n},o=x.bind(i);return o.listener=n,i.wrapFn=o,o}function E(e,t,n){var i=e._events;if(void 0===i)return[];var o=i[t];return void 0===o?[]:"function"==typeof o?n?[o.listener||o]:[o]:n?function(e){for(var t=new Array(e.length),n=0;n<t.length;++n)t[n]=e[n].listener||e[n];return t}(o):_(o,o.length)}function T(e){var t=this._events;if(void 0!==t){var n=t[e];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function _(e,t){for(var n=new Array(t),i=0;i<t;++i)n[i]=e[i];return n}function I(e,t,n,i){if("function"==typeof e.on)i.once?e.once(t,n):e.on(t,n);else{if("function"!=typeof e.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof e);e.addEventListener(t,(function o(r){i.once&&e.removeEventListener(t,o),n(r)}))}}function L(e){if("function"!=typeof e)throw new Error("obliterator/iterator: expecting a function!");this.next=e}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+e+".");w=e}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+e+".");return this._maxListeners=e,this},v.prototype.getMaxListeners=function(){return S(this)},v.prototype.emit=function(e){for(var t=[],n=1;n<arguments.length;n++)t.push(arguments[n]);var i="error"===e,o=this._events;if(void 0!==o)i=i&&void 0===o.error;else if(!i)return!1;if(i){var r;if(t.length>0&&(r=t[0]),r instanceof Error)throw r;var s=new Error("Unhandled error."+(r?" ("+r.message+")":""));throw s.context=r,s}var a=o[e];if(void 0===a)return!1;if("function"==typeof a)y(a,this,t);else{var l=a.length,c=_(a,l);for(n=0;n<l;++n)y(c[n],this,t)}return!0},v.prototype.addListener=function(e,t){return A(this,e,t,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(e,t){return A(this,e,t,!0)},v.prototype.once=function(e,t){return C(t),this.on(e,M(this,e,t)),this},v.prototype.prependOnceListener=function(e,t){return C(t),this.prependListener(e,M(this,e,t)),this},v.prototype.removeListener=function(e,t){var n,i,o,r,s;if(C(t),void 0===(i=this._events))return this;if(void 0===(n=i[e]))return this;if(n===t||n.listener===t)0==--this._eventsCount?this._events=Object.create(null):(delete i[e],i.removeListener&&this.emit("removeListener",e,n.listener||t));else if("function"!=typeof n){for(o=-1,r=n.length-1;r>=0;r--)if(n[r]===t||n[r].listener===t){s=n[r].listener,o=r;break}if(o<0)return this;0===o?n.shift():function(e,t){for(;t+1<e.length;t++)e[t]=e[t+1];e.pop()}(n,o),1===n.length&&(i[e]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",e,s||t)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(e){var t,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[e]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[e]),this;if(0===arguments.length){var o,r=Object.keys(n);for(i=0;i<r.length;++i)"removeListener"!==(o=r[i])&&this.removeAllListeners(o);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(t=n[e]))this.removeListener(e,t);else if(void 0!==t)for(i=t.length-1;i>=0;i--)this.removeListener(e,t[i]);return this},v.prototype.listeners=function(e){return E(this,e,!0)},v.prototype.rawListeners=function(e){return E(this,e,!1)},v.listenerCount=function(e,t){return"function"==typeof e.listenerCount?e.listenerCount(t):T.call(e,t)},v.prototype.listenerCount=T,v.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&(L.prototype[Symbol.iterator]=function(){return this}),L.of=function(){var e=arguments,t=e.length,n=0;return new L((function(){return n>=t?{done:!0}:{done:!1,value:e[n++]}}))},L.empty=function(){return new L((function(){return{done:!0}}))},L.fromSequence=function(e){var t=0,n=e.length;return new L((function(){return t>=n?{done:!0}:{done:!1,value:e[t++]}}))},L.is=function(e){return e instanceof L||"object"==typeof e&&null!==e&&"function"==typeof e.next};var N=L,P={};P.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,P.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var R=N,$=P,O=$.ARRAY_BUFFER_SUPPORT,k=$.SYMBOL_SUPPORT,H=function(e){var t=function(e){return"string"==typeof e||Array.isArray(e)||O&&ArrayBuffer.isView(e)?R.fromSequence(e):"object"!=typeof e||null===e?null:k&&"function"==typeof e[Symbol.iterator]?e[Symbol.iterator]():"function"==typeof e.next?e:null}(e);if(!t)throw new Error("obliterator: target is not iterable nor a valid iterator.");return t},F=H,G=function(e,t){for(var n,i=arguments.length>1?t:1/0,o=i!==1/0?new Array(i):[],r=0,s=F(e);;){if(r===i)return o;if((n=s.next()).done)return r!==t&&(o.length=r),o;o[r++]=n.value}},B=function(e){function n(t){var n;return(n=e.call(this)||this).name="GraphError",n.message=t,n}return t(n,e),n}(r(Error)),D=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B),V=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B),W=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B);function U(e,t){this.key=e,this.attributes=t,this.clear()}function j(e,t){this.key=e,this.attributes=t,this.clear()}function q(e,t){this.key=e,this.attributes=t,this.clear()}function z(e,t,n,i,o){this.key=t,this.attributes=o,this.undirected=e,this.source=n,this.target=i}function Y(e,t,n,i,o,r,s){var a,l,c,u;if(i=""+i,0===n){if(!(a=e._nodes.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" node in the graph.'));c=o,u=r}else if(3===n){if(o=""+o,!(l=e._edges.get(o)))throw new V("Graph.".concat(t,': could not find the "').concat(o,'" edge in the graph.'));var h=l.source.key,d=l.target.key;if(i===h)a=l.target;else{if(i!==d)throw new V("Graph.".concat(t,': the "').concat(i,'" node is not attached to the "').concat(o,'" edge (').concat(h,", ").concat(d,")."));a=l.source}c=r,u=s}else{if(!(l=e._edges.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=o,u=r}return[a,c,u]}U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},j.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},q.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},z.prototype.attach=function(){var e="out",t="in";this.undirected&&(e=t="undirected");var n=this.source.key,i=this.target.key;this.source[e][i]=this,this.undirected&&n===i||(this.target[t][n]=this)},z.prototype.attachMulti=function(){var e="out",t="in",n=this.source.key,i=this.target.key;this.undirected&&(e=t="undirected");var o=this.source[e],r=o[i];if(void 0===r)return o[i]=this,void(this.undirected&&n===i||(this.target[t][n]=this));r.previous=this,this.next=r,o[i]=this,this.target[t][n]=this},z.prototype.detach=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][t],delete this.target[i][e]},z.prototype.detachMulti=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][t],delete this.target[i][e]):(this.next.previous=void 0,this.source[n][t]=this.next,this.target[i][e]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return s.attributes[a]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){return Y(this,t,n,e,i)[0].attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return s.attributes.hasOwnProperty(a)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o,r){var s=Y(this,t,n,e,i,o,r),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o,r){var s=Y(this,t,n,e,i,o,r),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new D("Graph.".concat(t,": updater should be a function."));var u=a.attributes,h=c(u[l]);return u[l]=h,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];if(!c(a))throw new D("Graph.".concat(t,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],l=r[1];if(!c(l))throw new D("Graph.".concat(t,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];if("function"!=typeof a)throw new D("Graph.".concat(t,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes[i]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,r=""+arguments[1];if(!(i=l(this,o,r,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(r,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes.hasOwnProperty(i)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes[i]=o,this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof o)throw new D("Graph.".concat(t,": updater should be a function."));return r.attributes[i]=o(r.attributes[i]),this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(t,": provided attributes are not a plain object."));return o.attributes=i,this.emit("edgeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(t,": provided attributes are not a plain object."));return a(o.attributes,i),this.emit("edgeAttributesUpdated",{key:o.key,type:"merge",attributes:o.attributes,data:i}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new D("Graph.".concat(t,": provided updater is not a function."));return o.attributes=i(o.attributes),this.emit("edgeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],X=N,J=H,Q=function(){var e=arguments,t=null,n=-1;return new X((function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return i}))},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,i){var o=!1;for(var r in t)if(r!==i){var s=t[r];if(o=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),e&&o)return s.key}}function ne(e,t,n,i){var o,r,s,a=!1;for(var l in t)if(l!==i){o=t[l];do{if(r=o.source,s=o.target,a=n(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected),e&&a)return o.key;o=o.next}while(void 0!==o)}}function ie(e,t){var n,i=Object.keys(e),o=i.length,r=0;return new N((function(){do{if(n)n=n.next;else{if(r>=o)return{done:!0};var s=i[r++];if(s===t){n=void 0;continue}n=e[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function oe(e,t,n,i){var o=t[n];if(o){var r=o.source,s=o.target;return i(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected)&&e?o.key:void 0}}function re(e,t,n,i){var o=t[n];if(o){var r=!1;do{if(r=i(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),e&&r)return o.key;o=o.next}while(void 0!==o)}}function se(e,t){var n=e[t];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var o,r,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var u=r,h=u.key,d=u.attributes,p=u.source,m=u.target;if(l=i(h,d,p.key,m.key,p.attributes,m.attributes,r.undirected),e&&l)return h}}function le(e,t,n,i,o,r){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,o.in,r),e&&s))return s;if("in"!==i&&(s=a(e,o.out,r,i?void 0:o.key),e&&s))return s}if("directed"!==n&&(s=a(e,o.undirected,r),e&&s))return s}function ce(e,t,n,i,o,r,s){var a,l=n?re:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==i&&(a=l(e,o.in,r,s),e&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(e,o.out,r,s),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=o(c.key,c.attributes);if(e&&u)return c.key}}}function pe(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new he;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function me(e,t,n){var i=Object.keys(n),o=i.length,r=0;return new N((function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function ge(e,t,n,i,o){for(var r,s,a,l,c,u,h,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(u=c.target,m=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),m=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!m&&(h=o(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function fe(e){if(!c(e))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Se={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ae(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new W("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new W("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new W("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new W("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new W("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,u,a);e._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,u.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Me(e,t,n,i,o,r,s,l,u){if(!i&&"undirected"===e.type)throw new W("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new W("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new D("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new W("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new W("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var f=[p.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=p.attributes;p.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new W("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Ae(e,r,{}),v=!0,r===s&&(g=m,w=!0)),g||(g=Ae(e,s,{}),w=!0),d=new z(i,o,m,g,l),e._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,g.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,g.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Ee(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Se,e)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?U:"directed"===e.type?j:q;h(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",(function(){var e;do{e=o+r++}while(t._edges.has(e));return e})),h(s(t),"_options",e),Ce.forEach((function(e){return h(s(t),e,t[e])})),d(s(t),"order",(function(){return t._nodes.size})),d(s(t),"size",(function(){return t._edges.size})),d(s(t),"directedSize",(function(){return t._directedSize})),d(s(t),"undirectedSize",(function(){return t._undirectedSize})),d(s(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),d(s(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),d(s(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",(function(){return"graphology"})),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new W("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new W("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new W("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new W('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Ee(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Ee(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Ee(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Ee(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new W("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Ee(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new W("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Ee(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):G(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new D("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new D("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new D("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new D("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new D("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new D("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode((function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)})),this;if(!c(e))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new D("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=e.edges,!Array.isArray(o))throw new D("Graph.import: invalid edges. Expecting an array.");for(t=0,n=o.length;t<n;t++){ye(s=o[t]);var m=s,g=m.source,f=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,g,f,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,g,f,y)}}return this},o.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},o.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach((function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)})),t},o.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new W('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new W("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new W("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),o=this._edges.values();!0!==(t=o.next()).done;)xe(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},o.toJSON=function(){return this.export()},o.toString=function(){return"[object Graph]"},o.inspect=function(){var t=this,n={};this._nodes.forEach((function(e,t){n[t]=e.attributes}));var i={},o={};this._edges.forEach((function(e,n){var r,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(r=l,l=c,c=r);var u="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===o[u]?o[u]=0:o[u]++,a+="".concat(o[u],". ")):a+="[".concat(n,"]: "),i[a+=u]=e.attributes}));var r={};for(var s in this)this.hasOwnProperty(s)&&!Ce.has(s)&&"function"!=typeof this[s]&&"symbol"!==e(s)&&(r[s]=this[s]);return r.attributes=this._attributes,r.nodes=n,r.edges=i,h(r,"constructor",this.constructor),r},i}(g.exports.EventEmitter);"undefined"!=typeof Symbol&&(Te.prototype[Symbol.for("nodejs.util.inspect.custom")]=Te.prototype.inspect),[{name:function(e){return"".concat(e,"Edge")},generateKey:!0},{name:function(e){return"".concat(e,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(e){return"".concat(e,"EdgeWithKey")}},{name:function(e){return"".concat(e,"DirectedEdgeWithKey")},type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(e){["add","merge","update"].forEach((function(t){var n=e.name(t),i="add"===t?xe:Me;e.generateKey?Te.prototype[n]=function(o,r,s){return i(this,n,!0,"undirected"===(e.type||this.type),null,o,r,s,"update"===t)}:Te.prototype[n]=function(o,r,s,a){return i(this,n,!1,"undirected"===(e.type||this.type),o,r,s,a,"update"===t)}}))})),function(e){K.forEach((function(t){var n=t.name,i=t.attacher;i(e,n("Node"),0),i(e,n("Source"),1),i(e,n("Target"),2),i(e,n("Opposite"),3)}))}(Te),function(e){Z.forEach((function(t){var n=t.name,i=t.attacher;i(e,n("Edge"),"mixed"),i(e,n("DirectedEdge"),"directed"),i(e,n("UndirectedEdge"),"undirected")}))}(Te),function(e){ee.forEach((function(t){!function(e,t){var n=t.name,i=t.type,o=t.direction;e.prototype[n]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(e,t){if(0===e.size)return[];if("mixed"===t||t===e.type)return"function"==typeof Array.from?Array.from(e._edges.keys()):G(e._edges.keys(),e._edges.size);for(var n,i,o="undirected"===t?e.undirectedSize:e.directedSize,r=new Array(o),s="undirected"===t,a=e._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(r[l++]=i.key);return r}(this,i);if(1===arguments.length){e=""+e;var r=this._nodes.get(e);if(void 0===r)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n,i){var o=[];return le(!1,e,t,n,i,(function(e){o.push(e)})),o}(this.multi,"mixed"===i?this.type:i,o,r)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(n,':  could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(n,':  could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i,o){var r=[];return ce(!1,e,t,n,i,o,(function(e){r.push(e)})),r}(i,this.multi,o,s,t)}throw new D("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return ae(!1,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return le(!1,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(r,':  could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,':  could not find the "').concat(t,'" target node in the graph.'));return ce(!1,i,this.multi,o,a,t,n)}throw new D("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(){var e,t=Array.prototype.slice.call(arguments),n=t.pop();if(0===t.length){var o=0;"directed"!==i&&(o+=this.undirectedSize),"undirected"!==i&&(o+=this.directedSize),e=new Array(o);var s=0;t.push((function(t,i,o,r,a,l,c){e[s++]=n(t,i,o,r,a,l,c)}))}else e=[],t.push((function(t,i,o,r,s,a,l){e.push(n(t,i,o,r,s,a,l))}));return this[r].apply(this,t),e};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop(),n=[];return e.push((function(e,i,o,r,s,a,l){t(e,i,o,r,s,a,l)&&n.push(e)})),this[r].apply(this,e),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(){var e,t,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new D("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new D("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(e=n[0],t=n[1],n=[]):3===n.length?(e=n[1],t=n[2],n=[n[0]]):4===n.length&&(e=n[2],t=n[3],n=[n[0],n[1]]);var i=t;return n.push((function(t,n,o,r,s,a,l){i=e(i,t,n,o,r,s,a,l)})),this[r].apply(this,n),i}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="find"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return ae(!0,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return le(!0,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(r,':  could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,':  could not find the "').concat(t,'" target node in the graph.'));return ce(!0,i,this.multi,o,a,t,n)}throw new D("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,i,o,r,s,a){return t(e,n,i,o,r,s,a)})),!!this[r].apply(this,e)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,i,o,r,s,a){return!t(e,n,i,o,r,s,a)})),!this[r].apply(this,e)}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n.slice(0,-1)+"Entries";e.prototype[r]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(e,t){if(0===e.size)return N.empty();var n="mixed"!==t&&t!==e.type,i="undirected"===t,o=e._edges.values();return new N((function(){for(var e,t;;){if((e=o.next()).done)return e;if(t=e.value,!n||t.undirected===i)break}return{value:{edge:t.key,attributes:t.attributes,source:t.source.key,target:t.target.key,sourceAttributes:t.source.attributes,targetAttributes:t.target.attributes,undirected:t.undirected},done:!1}}))}(this,i);if(1===arguments.length){e=""+e;var n=this._nodes.get(e);if(!n)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){var i=N.empty();return"undirected"!==e&&("out"!==t&&void 0!==n.in&&(i=Q(i,ie(n.in))),"in"!==t&&void 0!==n.out&&(i=Q(i,ie(n.out,t?void 0:n.key)))),"directed"!==e&&void 0!==n.undirected&&(i=Q(i,ie(n.undirected))),i}(i,o,n)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(r,':  could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,':  could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i){var o=N.empty();return"undirected"!==e&&(void 0!==n.in&&"out"!==t&&i in n.in&&(o=Q(o,se(n.in,i))),void 0!==n.out&&"in"!==t&&i in n.out&&(t||n.key!==i)&&(o=Q(o,se(n.out,i)))),"directed"!==e&&void 0!==n.undirected&&i in n.undirected&&(o=Q(o,se(n.undirected,i))),o}(i,o,s,t)}throw new D("Graph.".concat(r,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t)}))}(Te),function(e){ue.forEach((function(t){(function(e,t){var n=t.name,i=t.type,o=t.direction;e.prototype[n]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return Object.keys(n.undirected);if("string"==typeof t)return Object.keys(n[t])}var i=[];return pe(!1,e,t,n,(function(e){i.push(e)})),i}("mixed"===i?this.type:i,o,t)}})(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));pe(!1,"mixed"===i?this.type:i,o,n,t)}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(e,t){var n=[];return this[r](e,(function(e,i){n.push(t(e,i))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(e,t){var n=[];return this[r](e,(function(e,i){t(e,i)&&n.push(e)})),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(e,t,n){if(arguments.length<3)throw new D("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[r](e,(function(e,n){i=t(i,e,n)})),i}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n[0].toUpperCase()+n.slice(1,-1),s="find"+r;e.prototype[s]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return pe(!0,"mixed"===i?this.type:i,o,n,t)}};var a="some"+r;e.prototype[a]=function(e,t){return!!this[s](e,t)};var l="every"+r;e.prototype[l]=function(e,t){return!this[s](e,(function(e,n){return!t(e,n)}))}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n.slice(0,-1)+"Entries";e.prototype[r]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return me(null,n,n.undirected);if("string"==typeof t)return me(null,n,n[t])}var i=N.empty(),o=new he;return"undirected"!==e&&("out"!==t&&(i=Q(i,me(o,n,n.in))),"in"!==t&&(i=Q(i,me(o,n,n.out)))),"directed"!==e&&(i=Q(i,me(o,n,n.undirected))),i}("mixed"===i?this.type:i,o,t)}}(e,t)}))}(Te);var _e=function(e){function n(t){var n=a({type:"directed"},t);if("multi"in n&&!1!==n.multi)throw new D("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new D('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),Ie=function(e){function n(t){var n=a({type:"undirected"},t);if("multi"in n&&!1!==n.multi)throw new D("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new D('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),Le=function(e){function n(t){var n=a({multi:!0},t);if("multi"in n&&!0!==n.multi)throw new D("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return e.call(this,n)||this}return t(n,e),n}(Te),Ne=function(e){function n(t){var n=a({type:"directed",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new D("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new D('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),Pe=function(e){function n(t){var n=a({type:"undirected",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new D("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new D('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te);function Re(e){e.from=function(t,n){var i=a({},t.options,n),o=new e(i);return o.import(t),o}}return Re(Te),Re(_e),Re(Ie),Re(Le),Re(Ne),Re(Pe),Te.Graph=Te,Te.DirectedGraph=_e,Te.UndirectedGraph=Ie,Te.MultiGraph=Le,Te.MultiDirectedGraph=Ne,Te.MultiUndirectedGraph=Pe,Te.InvalidArgumentsGraphError=D,Te.NotFoundGraphError=V,Te.UsageGraphError=W,Te}()},944:(e,t)=>{"use strict";t.Vb=void 0,t.Vb=function(e,t,n){var i=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var i=0,o=e.length,r=t.length,s=Math.floor(Math.max(o,r)/2)-1,a=new Array(o),l=new Array(r),c=0;c<o;c++)for(var u=Math.max(0,c-s);u<=Math.min(r,c+s+1);u++)if(!a[c]&&!l[u]&&e[c]===t[u]){++i,a[c]=l[u]=!0;break}if(0===i)return 0;var h=0,d=0;for(c=0;c<o;c++)if(a[c]){for(;!l[d];)d++;e.charAt(c)!==t.charAt(d++)&&h++}return(i/o+i/r+(i-(h/=2))/i)/3}(e,t,n),o=0;if(i>.7){for(var r=Math.min(e.length,t.length),s=0;e[s]===t[s]&&s<4&&s<r;)++o,s++;i+=.1*o*(1-i)}return i}},7106:e=>{"use strict";var t=e.exports=function(e,t,i){"function"==typeof t&&(i=t,t={}),n(t,"function"==typeof(i=t.cb||i)?i:i.pre||function(){},i.post||function(){},e,"",e)};function n(e,i,o,r,s,a,l,c,u,h){if(r&&"object"==typeof r&&!Array.isArray(r)){for(var d in i(r,s,a,l,c,u,h),r){var p=r[d];if(Array.isArray(p)){if(d in t.arrayKeywords)for(var m=0;m<p.length;m++)n(e,i,o,p[m],s+"/"+d+"/"+m,a,s,d,r,m)}else if(d in t.propsKeywords){if(p&&"object"==typeof p)for(var g in p)n(e,i,o,p[g],s+"/"+d+"/"+g.replace(/~/g,"~0").replace(/\//g,"~1"),a,s,d,r,g)}else(d in t.keywords||e.allKeys&&!(d in t.skipKeywords))&&n(e,i,o,p,s+"/"+d,a,s,d,r)}o(r,s,a,l,c,u,h)}}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:e=>{"use strict";var t=[];function n(e){for(var n=-1,i=0;i<t.length;i++)if(t[i].identifier===e){n=i;break}return n}function i(e,i){for(var r={},s=[],a=0;a<e.length;a++){var l=e[a],c=i.base?l[0]+i.base:l[0],u=r[c]||0,h="".concat(c," ").concat(u);r[c]=u+1;var d=n(h),p={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)t[d].references++,t[d].updater(p);else{var m=o(p,i);i.byIndex=a,t.splice(a,0,{identifier:h,updater:m,references:1})}s.push(h)}return s}function o(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,o){var r=i(e=e||[],o=o||{});return function(e){e=e||[];for(var s=0;s<r.length;s++){var a=n(r[s]);t[a].references--}for(var l=i(e,o),c=0;c<r.length;c++){var u=n(r[c]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}r=l}}},7659:e=>{"use strict";var t={};e.exports=function(e,n){var i=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540:e=>{"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},5056:(e,t,n)=>{"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7825:e=>{"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var o=void 0!==n.layer;o&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,o&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var r=n.sourceMap;r&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(r))))," */")),t.styleTagTransform(i,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},1113:e=>{"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},8926:(e,t,n)=>{"use strict";n.r(t),n.d(t,{GetRegionEditor:()=>uo,PackageFunctions:()=>Lr,SeqActivityCliffsEditor:()=>mo,SeqPaletteCustom:()=>Nr,SequenceSpaceEditor:()=>po,SplitToMonomersEditor:()=>ho,SubsequenceSearchTopMenu:()=>Zo,_package:()=>_r,activityCliffs:()=>Eo,addCopyMenu:()=>mr,alignSequences:()=>Oo,bioSubstructureFilter:()=>rr,bioSubstructureFilterTest:()=>sr,compositionAnalysis:()=>ko,compositionAnalysisWidget:()=>vo,convertColumnAction:()=>Bo,convertDialog:()=>Go,customSequenceCellRenderer:()=>go,demoBioActivityCliffs:()=>yr,demoBioAtomicLevel:()=>br,demoBioSequenceSpace:()=>fr,demoBioSimilarityDiversity:()=>gr,detectMacromoleculeProbe:()=>Sr,diversitySearchTopMenu:()=>Yo,diversitySearchViewer:()=>zo,fastaSequenceCellRenderer:()=>fo,getBioLib:()=>so,getHelmMonomers:()=>Uo,getMolFromHelm:()=>xr,getMonomerLibHelper:()=>io,getRegion:()=>xo,getRegionApp:()=>cr,getRegionHelmApp:()=>ur,getRegionPanel:()=>lo,getRegionTopMenu:()=>Mo,getSeqHandler:()=>ao,getSeqHelper:()=>Ar,helmPreprocessingFunction:()=>_o,importBam:()=>Fo,importFasta:()=>Ho,initBio:()=>oo,libraryPanel:()=>co,longSeqTableFasta:()=>dr,longSeqTableHelm:()=>pr,longSeqTableSeparator:()=>hr,macroMolColumnPropertyPanel:()=>bo,macromoleculeDifferenceCellRenderer:()=>wo,macromoleculePreprocessingFunction:()=>To,manageLibrariesView:()=>er,manageMonomerLibraries:()=>Qo,manageMonomerLibrariesView:()=>nr,manageMonomerLibrariesViewTreeBrowser:()=>ir,manageMonomersView:()=>tr,monomerCellRenderer:()=>Do,multipleSequenceAlignmentDialog:()=>$o,saveAsFasta:()=>or,sdfToJsonLib:()=>vr,searchSubsequenceEditor:()=>Ko,separatorSequenceCellRenderer:()=>yo,seq2atomic:()=>wr,seqIdentity:()=>Cr,sequence3dStructureWidget:()=>Ro,sequenceAlignment:()=>Co,sequenceIdentityScoring:()=>Xo,sequenceSimilarityScoring:()=>Jo,sequenceSpaceTopMenu:()=>Io,sequenceTooltip:()=>ro,similaritySearchTopMenu:()=>qo,similaritySearchViewer:()=>jo,splitToMonomersTopMenu:()=>Wo,test1:()=>Pr,testDetectMacromolecule:()=>Vo,toAtomicLevel:()=>Lo,toAtomicLevelAction:()=>No,toAtomicLevelPanel:()=>Po,vdRegionsViewer:()=>Ao,webLogoAggApp:()=>lr,webLogoLargeApp:()=>ar,webLogoViewer:()=>So});var i,o,r=n(4328),s=n(7389),a=n(6082),l=n(684),c=n(9039);(o=i||(i={})).EUCLIDEAN="EUCLIDEAN",o.MANHATTAN="MANHATTAN";var u=n(1858),h=n(5072),d=n.n(h),p=n(7825),m=n.n(p),g=n(7659),f=n.n(g),y=n(5056),b=n.n(y),v=n(540),w=n.n(v),C=n(1113),S=n.n(C),A=n(7939),x={};x.styleTagTransform=S(),x.setAttributes=b(),x.insert=f().bind(null,"head"),x.domAPI=m(),x.insertStyleElement=w(),d()(A.A,x),A.A&&A.A.locals&&A.A.locals;var M=function(e,t,n,i){return new(n||(n=Promise))((function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};let E=null,T=null;function _(e,t){return e&&""!=e?e:t}n(2780);class I{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n    the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n  used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return M(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter(),null==E))return null;let e=null;return"info"in E&&(e=E.info),e?_(e.description,_(e.vendor,"No GPU description available")):"No GPU description available"}))}().then((e=>{e?(this.useWebGPU.tooltip+=` (${e})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const N="MCL";var P=n(1991),R=n.n(P);a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class ${constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class O{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach((n=>{null!=e[n].value&&(t[n]=e[n].value)})),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=s.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=s.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[c.c.UMAP,c.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=s.inputs([]),this.dbScanSettingsDiv=s.inputs([]),this.preprocessingFuncSettingsDiv=s.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.c.UMAP]:new I,[c.c.T_SNE]:new L},this.dbScanParams=new $,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.GP]}).forEach((e=>{const t=e.options.get(l.n3)??"",n=e.friendlyName??e.name,i=e.options.get(l.C0)??"",o=e.options.get(l._X)??"",r=e.options.get(l.Gi)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!o.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:i?i.split(","):[],units:o?o.split(","):[],distanceFunctions:r?r.split(","):[]})})),this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,items:r.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let t=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:e=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=s.icons.settings((()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let o=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,o=!0),o||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let u=!1;this.preprocessingFuncSettingsIcon=s.icons.settings((async()=>{u?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),u=!u}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find((e=>!!this.columnFunctionsMap[e.name]))??null,t=s.input.column("Column",{table:this.tableInput.value,value:e,nullable:!1,onValueChanged:()=>this.onColumnInputChanged(),filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach((e=>this.colInputRoot.append(e))),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;if(!e)return;const t=()=>{this.columnFunctionsMap={},e.columns.toList().forEach((e=>{Object.keys(this.supportedFunctions).forEach((t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,o=this.supportedFunctions[t].units,r=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!o.length||e.meta.units&&o.includes(e.meta.units);r&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))}))})),this.regenerateColInput()};t(),R()(e.columns).some((e=>!!e.getTag(a.Tags.SemanticDetectionDuration)))||e.meta.detectSemanticTypes().then((()=>{t()}))}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((e=>this.similarityMetricInputRoot.append(e))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return s.empty(e),Object.keys(t).forEach((n=>{const i=t[n],o="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):s.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(o.root),i.disable?(o.enabled=!1,s.tooltip.bind(o.input??o.root,i.disableTooltip??"")):s.tooltip.bind(o.input??o.root,i.tooltip)})),e}async createPreprocessingFuncParamsDiv(e,t){if(s.empty(e),t.inputs.length<3)return s.div();const n=t.prepare(),i=await n.buildEditor(s.div());for(let o=2;o<t.inputs.length;o++){const r=t.inputs[o];(this.preprocessingFunctionSettings[r.name]||n.inputParams[t.inputs[o].name].value||r.defaultValue)&&(this.preprocessingFunctionSettings[r.name]=this.preprocessingFunctionSettings[r.name]??n.inputParams[r.name].value??r.defaultValue);const s=i.find((e=>e.property.name===r.name));s&&(null!==this.preprocessingFunctionSettings[r.name]&&void 0!==this.preprocessingFunctionSettings[r.name]&&(s.value=this.preprocessingFunctionSettings[r.name]),s.onChanged.subscribe((e=>{this.preprocessingFunctionSettings[r.name]=e})),e.append(s.root))}return e}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])})),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}}var k=n(9713),H=n(6295);const F=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex((e=>n<e));e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class B{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,p=1,m=0,g=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*u),f=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*f+4*a*(a-1)-7)/2-.5),p=f-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:f-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),o?t(o):(h.set(r,i),s<m&&(m=s),a>g&&(g=a),e())}}))}await Promise.all(l),n&&h.forEach(((e,t)=>{h[t]=(e-m)/(g-m)})),i(h)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class D{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,r=e.distance;for(let e=0;e<o;e++)i[Math.floor(r[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),u=new Float32Array(s),h=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<o;e++)r[e]<m&&(l[p]=h[e],c[p]=d[e],u[p]=r[e],p++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),r.forEach(((e,t)=>r[t].threshold=o));const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,u)=>{const h=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:p,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}}));const p=await Promise.all(h),m=p.reduce(((e,t)=>e+t.i.length),0),g=new Int32Array(m),f=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}}));const d=await Promise.all(u),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),u=new Array(this._workerCount),h=e[0].length,d=e.map((e=>e[t])),p=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise(((n,i)=>{const u=t*p,m=t===this._workerCount-1?h:(t+1)*p;m<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map((e=>e.slice(u,m))),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}}));const m=await Promise.all(u),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)G(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}}));const d=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(o).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(o).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise(((c,h)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}}));const d=await Promise.all(h),p=d.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let g=0;for(const e of d)m.set(e.distance,g),g+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=F(e[l])||F(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var V,W,U=n(8774);(W=V||(V={})).none="none",W.bold="bold",W.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=V.none){var r;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new U.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,p,m,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const S=this.sp.pointToScreen(this.lines.to[e]);let A=null==S?void 0:S.x,x=null==S?void 0:S.y;const M=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&A&&x&&Math.hypot(A-w,x-C)/M>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let S=null;if(b){t=this.getLineLength(w,C,A,x);const o=this.getPointOnDistance(w,C,A,x,i,t),r=this.getPointOnDistance(A,x,w,C,n,t);w=o.x,C=o.y,A=r.x,x=r.y,S=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,A,x,e):this.findControlPoint(b,A,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(S.x,S.y,A,x)}else(!this.lines.skipShortLines||Math.pow(A-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(A,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,A,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,A,x,i,t),n=b?S.x:w,o=b?S.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const p=new U.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(e-a),g=Math.abs(t-p),f=m+g;(!d||d>f)&&(d=f),h[r]=Math.max(m,g),c[r]=a,u[r]=p}for(let e=0;e<c.length;e++)h[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const s=n-o*((n-e)/r),l=i-o*((i-t)/r);return new a.Point(s,l)}findControlPoint(e,t,n,i,o,r){const s=t+(i-t)/2,l=n+(o-n)/2;let c=s-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*u,l-d/2*c):new a.Point(s-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const q="dimensionality-reducer-terminate-event";var z,Y,K=n(3629);async function Z(e,t,i,o,s,a,l){let c=await async function(e,t,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(q).subscribe((()=>{try{h?.terminate()}finally{d.unsubscribe()}}));h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{F(n)||F(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout((()=>h.terminate()),100)):l&&l(n,i,t)}}))}(e,i,t,o,s,a,l);return c=c.map((e=>(0,K.S8)(e))),c}(Y=z||(z={})).EUCLIDEAN="EUCLIDEAN",Y.MANHATTAN="MANHATTAN";const X={[z.EUCLIDEAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[z.MANHATTAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const ee={[J.HAMMING]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.EUCLIDEAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(e,t){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(e,t){return`\n      let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${e+1}u>;\n      var horizontalGaps: array<u32, ${e+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.SOKAL]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(e,t){return`\n    let range = suppInfo.range${t};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},te={[J.HAMMING]:e=>Math.ceil(e/30),[J.EUCLIDEAN]:e=>Math.ceil(e/30),[J.MANHATTAN]:e=>Math.ceil(e/30),[J.TANIMOTO]:e=>Math.ceil(e/30),[J.SOKAL]:e=>Math.ceil(e/30),[J.COSINE]:e=>Math.ceil(e/30),[J.ASYMMETRIC]:e=>Math.ceil(e/30),[J.LEVENSTEIN]:e=>Math.ceil(e*e/60),[J.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[J.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[J.Difference]:e=>1,[J.OneHot]:e=>Math.ceil(e/40),[J.VECTOR_COSINE]:e=>Math.ceil(e/30)},ne={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};function ie(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))((function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))}(this,void 0,void 0,(function*(){const s=yield function(){return M(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==E))return null;let e=!1;if(T&&(T.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!T||e){const e=1e9,t=E.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return T=yield E.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),T}catch(e){return console.error("Failed to create device with required limits",e),T=yield E.requestDevice(),T}}return T}))}();if(!s)return null;const a=Object.values(J);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(z).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map(((e,t)=>function(e,t=J.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some((e=>"string"==typeof e))?(s="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(s="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(s="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(s="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(s="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((e=>e.length)));if(!ne[s]||!ne[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce(((e,t)=>Math.max(e,t)),0),h=te[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*u);a.forEach(((e,t)=>{p.set(e,t*u)}));let m="",g=0,f="FLOAT32ARRAY",y=null;if(t===J.NEEDLEMAN_WUNSCH||t===J.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);i.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===J.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=p.reduce(((e,t)=>Math.min(e,t)),p[0]),t=p.reduce(((e,t)=>Math.max(e,t)),p[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=z.MANHATTAN);let d=h.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=h.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),g=new Uint32Array(c*u);h.forEach(((e,t)=>{g.set(e.arraySizes,t*u)}));const f=1e4,y=100,b=h.reduce(((e,t)=>e+t.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,S=u*(u-1)/2,A=Math.ceil(S/f),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${A} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${u}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${u}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${oe(n,h.map((e=>e.maxEntryLen)),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(f),L=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(S/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?S-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);I[e]=O,L[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce(((e,t)=>e+t.sourceArraySize),0),H=h.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,G=k*Uint32Array.BYTES_PER_ELEMENT;let B=G;const D=15&G;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let U=0;new Uint32Array(W,U,f).set(I),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,f).set(L),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,f).set(N),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,f).set(P),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,g.length).set(g),U+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,U,c).set(o),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(W,U,n).set(e.flatSourceArray),U+=n*t.BYTES_PER_ELEMENT}V.unmap();const j=H*Uint32Array.BYTES_PER_ELEMENT;let q=j;const Y=15&j;0!==Y&&(q+=16-Y),q=Math.max(q,16);const K=s.createBuffer({label:"supp info buffer",size:q,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),Z=K.getMappedRange();let X=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(Z,X,e.suppInfoBuffer.length).set(e.suppInfoBuffer),X+=e.suppInfoBuffer.byteLength);0===X&&new Uint32Array(Z,0,4).set([1,1,1,1]),K.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let ee=Q;const ie=15&Q;0!==ie&&(ee+=16-ie);const re=s.createBuffer({label:"results buffer",size:ee,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:_.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(_),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,F);o+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every((e=>1===e));const u=c.reduce(((e,t)=>e+t),0),h=new Uint32Array(u),d=new Uint32Array(u),p=new Float32Array(u);let m=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),m),d.set(a.subarray(e*y,e*y+t),m),p.set(l.subarray(e*y,e*y+t),m),m+=t)}le.push(h),ce.push(d),ue.push(p),ae.unmap()}const de=le.reduce(((e,t)=>e+t.length),0),pe=new Uint32Array(de),me=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)pe.set(le[e],fe),me.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),K.destroy(),re.destroy(),ae.destroy(),{i:pe,j:me,distance:ge}}))}function oe(e,t,n,i){return e.map(((e,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${ee[e](t[i],i)}\n        }\n      `)).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${e.length}>;\n        ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n        ${X[i](e.length)}\n      }\n    \n    `}let re=0;const se="cliffsDf",ae=new u.Subject,le="SALI",ce="line index",ue=["From","To"],he="filterCliffs";async function de(e,t,i,o,l,c,u,h,d,p,m,g,f,y,b,v,w){re++;const C=c/100;let S,A=!1;const x=g.inputs,M=await g.apply({[x[0].name]:t,[x[1].name]:u,...d.preprocessingFuncArgs??{}});let E=[];if(h===N){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((e,t)=>{h=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([M.entries],c,[1],"MANHATTAN",[u],[M.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),E=[t.embedX,t.embedY]}else E=await Z([M.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[M.options??{}]});if(E.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<E.length;++t)e.columns.addNewFloat(i[t]).init((e=>E[t][e]));let T=null;if(d.useWebGPU)try{T=await ie([M.entries],C,[u],z.MANHATTAN,[1],[M.options??{}])}catch(e){console.error(e)}T||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),T=await(new D).calc(M.entries,u,C,M.options));const _=await async function(e,t){const n=e.distance.map(((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0})),i=e.distance.map((e=>1-e)),o=e.i,r=e.j,s=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{s.set(e.i[n],!0),s.set(e.j[n],!0)})),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:s}}(T,l),I=function(e,t,n,i,o,r,s){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(s.get(i[e])>s.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return a.Column.fromList("double",t,l)}(t.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,_.saliVals,_.n1,_.n2,0,l);e.columns.add(I);const L=_.cliffsBitSet,P=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}(_.saliVals),$=.8/(P.max-P.min),O=r.shell.getTableView(e.name),H=O.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:I.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:o}),F=function(e,t,n,i,o,r,s,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-s.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=a.DataFrame.create(c.from.length);return ue.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),r),u.col(e).semType=o})),u.columns.addNewFloat("Δ activity").init((e=>Math.abs(i.get(c.from[e])-i.get(c.to[e])))),u.columns.addNewInt(ce).init((e=>e)),u.columns.addNewFloat(le).init((e=>t.saliVals[e])),u.columns.addNewFloat("Similarity").init((e=>t.simVals[e])),u.name=`${se}${re}`,{lines:c,linesDf:u}}(e,_,t,l,p,m,P,$);F.lines.skipMultiLineCalculation=!0,F.linesDf.col(le).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const G=new j(H,i[0],i[1],F.lines,V.none),B=b?b(F.linesDf,ue).sort([le],[!1]):F.linesDf.plot.grid().sort([le],[!1]);B.col(ce)&&(B.col(ce).visible=!1),e.temp[".cliffsDfGrid"]=B;const W=s.button(`${F.linesDf.rowCount} cliffs`,(()=>{const e=R()(O.viewers).some((e=>e.dataFrame.name===`${se}${re}`));w&&!e&&O.addViewer(B),O.dockManager.dock(B,"down",null,"Activity cliffs",v??.2)}));W.classList.add("scatter_plot_link","cliffs_grid");const U=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(H.dataFrame.setTag(he,i[0]),e.filter.and(L),ae.next(i[0])):(H.dataFrame.setTag(he,""),e.filter.setAll(!0),ae.next(""))}});H.root.prepend(s.divH([W,U.root],"cliffs_div")),ae.subscribe((e=>{U.enabled=""===e||e===i[0]})),e.onRowsFiltering.subscribe((()=>{U.value&&e.filter.and(_.cliffsBitSet)}));const q=r.events.onViewerClosed.subscribe((e=>{e.args.viewer===H&&(O.dockManager.close(B.root),q.unsubscribe(),O.subs=O.subs.filter((e=>e!==q)))}));return O.subs.push(q),F.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<F.linesDf.rowCount;e++)F.lines.widths[e]=e===F.linesDf.currentRowIdx?3:1;G.linesToRender=F.lines;const n=F.linesDf.currentCol&&F.linesDf.currentCol.name===ue[1]?F.lines.to:F.lines.from,o=-1!==F.linesDf.currentRowIdx?F.linesDf.currentRowIdx:null;if(H.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=F.linesDf.currentRowIdx;G.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,p=(n<o?n:o)+s/2-h/2,m=(i>r?i:r)-a/2+d/2;return{zoomLeft:p,zoomRight:p+h,zoomTop:m,zoomBottom:m-d}}(H.viewport.width,H.viewport.height,H.dataFrame.get(i[0],F.lines.from[n]),H.dataFrame.get(i[1],F.lines.from[n]),H.dataFrame.get(i[0],F.lines.to[n]),H.dataFrame.get(i[1],F.lines.to[n]));H.zoom(a,u,c,h),U.value?e.filter.and(L):!0===U.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,i,o,a,l,c,u){const h=t.getPane("Cliff Details");s.empty(h.root);const d=u({points:[n,i],lineId:o,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout((()=>{r.shell.o=t.root}),500)}(e,S,F.lines.from[o],F.lines.to[o],o,t,l,F.linesDf.get(le,o),y);const n=H.dataFrame.getSortedOrder(O.grid.sortByColumns,O.grid.sortTypes);O.grid.scrollToCell(t.name,n.indexOf(H.dataFrame.currentRowIdx))}),1e3)}})),F.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<F.linesDf.rowCount;e++){const n=F.linesDf.selection.get(e);n&&(t.set(F.lines.from[e],!0),t.set(F.lines.to[e],!0)),F.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),G.linesToRender=F.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(A?A=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<F.lines.colors.length;e++)F.lines.colors[e]="0,128,0";G.linesToRender=F.lines})(B.dataFrame))})),G.lineClicked.subscribe((t=>{if(A=!0,G.currentLineId=t.id,-1!==t.id){const n=F.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),F.linesDf.selection.copyFrom(n)):(F.linesDf.currentRowIdx!==t.id&&(F.linesDf.currentRowIdx=t.id,e.currentRowIdx=F.lines.from[t.id]),F.linesDf.selection.copyFrom(n));const i=F.linesDf.getSortedOrder(B.sortByColumns,B.sortTypes);B.scrollToCell(ue[0],i.indexOf(t.id))}),500)}})),G.lineHover.pipe((0,k.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&s.tooltip.show(f({lineId:n.id,points:[F.lines.from[n.id],F.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)})),H.addProperty("similarityLimit","double",C),S=function(){const e=s.accordion(),t=s.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(s.span([t,s.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),r.shell.o=e.root,e}(),H}var pe,me=n(6863),ge=n(2003),fe=n(3516),ye=n(6718),be=n(3077),ve=n(439);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var we=n(9192);class Ce{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Se extends O{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ce}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ae,xe,Me;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function Te(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}async function _e(e,t,i,o,c,u,h,d=!0,p=!1,m={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==o.length||t.length!==u.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??r.shell.tableView(e.name)??r.shell.addTableView(e):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let S;try{const A=Ee(e);function x(n,o,r){let c=null,u=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),u=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),u=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!S&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Te(t,i)}))),g[l.YP]&&(S?.root&&s.setUpdateIndicator(S.root,!1),c.init((e=>r[0]?r[0][e]:void 0)),u.init((e=>r[1]?r[1][e]:void 0)));const h=n/o*100;C.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function M(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Te(t,i)}),s.setUpdateIndicator(S.root,!0));const p=r.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&S?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===S?.getOptions()?.look?.title&&(r.events.fireCustomEvent(q,{}),p.unsubscribe(),n?.(),C.close())})),f=new Promise((async(r,s)=>{try{n=r;const s=[];let a=o,d=c,p=h;if(b&&t.every((e=>e.isNumerical))){const n=t.map((e=>e.toList())),i=new Array(e.rowCount).fill(0).map(((e,n)=>new Float32Array(t.length)));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,r=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[r]:o[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}r(await Z(s.map((e=>e.entries)),i,a,d,h,m,g[l.vb]?void 0:x))}catch(e){s(e)}})),y=await f;return C.close(),p.unsubscribe(),y}const E=await M();if(p&&E){const T=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))((function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))}(this,void 0,void 0,(function*(){return new Promise((function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}}))}))}(E[0],E[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init((e=>_[e].toString())),S&&(S.props.colorColumnName=I)}catch(L){r.shell.error("Clustering embeddings failed"),console.error(L)}finally{T.close()}}if(E){const N=e.columns.byName(A[0]),P=e.columns.byName(A[1]);if(N.init((e=>E[0][e])),P.init((e=>E[1][e])),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){r.shell.error("Post-processing failed"),console.error(O)}if(S)return s.setUpdateIndicator(S.root,!1),S.helpUrl="/help/compute/sequence-space",S}}catch(k){r.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),S&&s.setUpdateIndicator(S.root,!1)}};return new Promise((async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await C();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await C();t(e)}}catch(e){n(e)}}))}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ae||(Ae={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(xe||(xe={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Me||(Me={})),Object.prototype.toString;var Ie=n(6873),Le=n(4356),Ne=n(6717),Pe=n(4870),Re=n(3856),$e=n(6882),Oe=n(7278),ke=n(5553),He=n(6642),Fe=n(3599),Ge=n(673),Be=n(8312);class De extends He.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,_r.logger),(0,ye.pj)().then((e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,Be.Q)().then((e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var Ve=n(4139);const We=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class Ue extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(e){this.seqHandler.column.set(this.rowIdx,e)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===ve.YI.DNA}isRna(){return this.seqHandler.alphabet===ve.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===ve.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(e,t){if(null==t.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=t.column.dataFrame.cell(e,t.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=e,this.seqHandler=t}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const e=(0,Oe.qp)(this.helm),t=[],n=/\(|\)/;for(let i=0;i<e.length;i++){const o=e.getOriginal(i),r=o.split(n).filter((e=>!!e));3===r.length?(t.push(r[0]),t.push(r[1]),t.push(r[2])):t.push(o)}return new Oe.Mu(t,this.seqHandler.defaultGapOriginal)}}const je=ge.zS;function qe(e){const t=!R().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],i=t?"":" ";for(const[t,o]of R().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class ze extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=_r.seqHelper}getRendererBack(e){const[t,n,i]=(0,He.BG)(e);if(n.meta.units!==ge.Hi.CUSTOM)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){if(e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate(),e.cell.column.meta.units===ge.Hi.CUSTOM){const n=this.getRendererBack(e);n?.onClick(e,t)}}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,ke.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe((e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,He.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(_r.properties?_r.properties.maxMonomerLength:4)??50;if(Re.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Re.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new $e.Jy(a,l,_r.logger,d,(()=>{const{font:e,fontWidth:t}=$e.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:je}})),l.temp[".mm.cellRenderer.settingsChanged"],Ge.s.true,p.init().then((()=>{}))),p.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){if(r.cell.column?.meta?.units!==ge.Hi.CUSTOM)this.renderInt(e,t,n,i,o,r,s);else{const a=this.getRendererBack(r);a?.render(e,t,n,i,o,r,s)}}}class Ye extends De{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[ge.gp.separator],h=this.tableCol.meta.units;i=(0,$e.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[We.notationProvider]?.separatorSplitter??(0,Oe.Iv)(h,u),g=m(d),f=m(p),y=R().count(0).take(g.length).map((e=>g.getCanonical(e))).toArray(),b=R().count(0).take(f.length).map((e=>f.getCanonical(e))).toArray(),v=this.tableCol.getTag(ge.gp.alphabet);Ze(e,t,n,i,o,y,b,v===ge.YI.RNA||v===ge.YI.DNA?Fe.o.NUCLEOTIDE:Fe.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new Ye(t,n)),o}}class Ke extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ve.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){Ye.getOrCreate(r).render(e,t,n,i,o,r,s)}}function Ze(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(ve.b9[ge.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(R()(t).toArray()):e=l(R()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(qe(r).join("")),d=e.measureText(qe(s).join("")),p=Math.max(h.width,d.width);c&&(i=p+4*r.length,e.canvas.width=p+4*r.length);let m=Math.max(t,t+(i-(p+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=$e.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=$e.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Re.oZ)(e,n,m,g-h,i,o,{color:d,pivot:0,left:!0}),p=(0,Re.oZ)(e,c,m,g+h,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),u&&(u[t]=Xe(n,c,d,r,g,h,o))}else m=(0,Re.oZ)(e,n,m,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Xe(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(qe([e]).join("")).width,u=l.measureText(qe([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Re.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,Re.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var Je,Qe=n(8070),et=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Je||(Je={}));const tt=new class{constructor(){this.regionTypes=[Je.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=et.fH.Entropy,this.filterSource=et.Fo.filterSource}};var nt=n(7602),it=n(250);const ot=Je;var rt,st;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(rt||(rt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(st||(st={}));const at=tt;class lt extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(st.skipEmptyPositions,at.skipEmptyPositions,{category:rt.DATA}),this.regionTypes=this.stringList(st.regionTypes,at.regionTypes,{category:rt.DATA,choices:Object.values(ot).filter((e=>e!=ot.Unknown))}),this.chains=this.stringList(st.chains,at.chains,{category:rt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(st.fitWidth,at.fitWidth,{category:rt.LAYOUT}),this.positionWidth=this.float(st.positionWidth,at.positionWidth,{category:rt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(st.positionHeight,at.positionHeight,{category:rt.LAYOUT,choices:Object.keys(et.fH)}),this.filterSource=this.string(st.filterSource,at.filterSource,{category:rt.BEHAVIOR,choices:Object.values(et.lT)}),this.viewSyncer=new nt.g(_r.logger)}static viewerCounter=-1;viewerId=++lt.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case st.regionTypes:case st.chains:this.setData(this.regions)}switch(e.name){case st.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[it.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case st.fitWidth:case st.positionWidth:this.calcSize();break;case st.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[it.n5.positionHeight]:this.positionHeight});this.calcSize();break;case st.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;_r.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){_r.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){_r.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find((t=>t.order==n[e]&&t.chain==o));i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(et.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),_r.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){_r.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[it.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[it.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(st.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[it.n5.filterSource]:this.filterSource})}}}))}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,Qe.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class ct{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class ut{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class ht{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new ut(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ct);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ct);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function dt(e,t,n="Morgan",i=1,o=.6){const r=e.length,s=_r.seqHelper.getSeqHandler(e),a=Array(r);let l=1;const c=new Map,u=e.categories,h=e.getRawData();for(let t=0;t<r;t++){if(null===u[h[t]]||e.isNone(t)){a[t]=null;continue}a[t]="";const n=s.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);c.has(i)||(c.set(i,String.fromCharCode(l)),l++),a[t]+=c.get(i)}}let d={};if(t===me.Z.MONOMER_CHEMICAL_DISTANCE||t===me.Z.NEEDLEMANN_WUNSCH){const e=Array.from(c.keys()),r=await(0,ye.A7)(e,n),s={};Object.entries(r.alphabetIndexes).forEach((([e,t])=>{s[c.get(e)]=t}));const l=a.reduce(((e,t)=>Math.max(e,t?.length||0)),0);d={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:l},t===me.Z.NEEDLEMANN_WUNSCH&&(d.gapOpen=i,d.gapExtend=o)}return{seqList:a,options:d}}var pt=n(4954);function mt(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))})),t}function gt(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,i)=>{n[i]=e.activityCol.get(t)}));const i={},o=_r.seqHelper.getSeqHandler(e.seqCol),r=o.defaultBiotype,a=yt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),r,i);return t.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(bt(i)),t.append(ft("Activity delta",Math.abs(n[0]-n[1]))),t.append(ft("Cliff",e.sali)),t}function ft(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function yt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=_r.monomerLib;return Ze(r,0,0,0,30,R().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),R().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),n,s,!0,i),o}function bt(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function vt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ge.gp.separator,e.col(t[0]).getTag(ge.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class wt extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>{this.gridSelect||this.render(e)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(e),this.debounceTimer=null}),100)}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class Ct extends wt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[me.Z.NEEDLEMANN_WUNSCH,me.Z.HAMMING,me.Z.LEVENSHTEIN,me.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,ge.gp.aligned,ge.gp.separator,ge.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",me.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===me.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}}const St={gapPenalty:1,matchScore:1,gapSymbol:ve.b9[ve.Hi.FASTA],localAlignment:!1};class At extends Ct{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new u.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init((e=>this.targetColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.targetColumn.getTag(e))));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe((e=>{n&&clearTimeout(n),(t.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(t)}),300),this.gridSelect=!0)})),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Pe.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Pe.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await dt(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new D).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,o=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...St,...n},o=e.length,r=t.length,s=Array(o+1).fill(0).map((()=>Array(r+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<o+1;n++)for(let o=1;o<r+1;o++)s[n][o]=Math.max(0,s[n-1][o-1]+(e.getCanonical(n-1)===t.getCanonical(o-1)?i.matchScore:-i.matchScore),s[n-1][o]-i.gapPenalty,s[n][o-1]-i.gapPenalty),s[n][o]>=a&&(a=s[n][o],l=[n,o]);let c=i.localAlignment?l[0]:o,u=i.localAlignment?l[1]:r,h=new Array(0),d=new Array(0);for(;c>0&&u>0;){const n=Math.max(s[c-1][u-1],s[c-1][u],s[c][u-1]);s[c][u]==s[c-1][u-1]+i.matchScore&&n==s[c-1][u-1]?(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1):s[c][u]==s[c-1][u]-i.gapPenalty?(d.push(i.gapSymbol),h.push(e.getCanonical(c-1)),c-=1):s[c][u]==s[c][u-1]-i.gapPenalty?(h.push(i.gapSymbol),d.push(t.getCanonical(u-1)),u-=1):(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1)}h=[...R().count(0).take(c).map((t=>e.getCanonical(t))),...h.reverse(),...i.localAlignment?R().count(l[0]).take(o).map((t=>e.getCanonical(t))):[]],d=[...R().count(0).take(u).map((e=>t.getCanonical(e))),...d.reverse(),...i.localAlignment?R().count(l[1]).take(r).map((e=>t.getCanonical(e))):[]];const p=c,m=u;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:h=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...h],d.length>h.length?h.push(...new Array(d.length-h.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(h.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:h.join(""),seq2:d.join(""),seq1Splitted:new Oe.Mu(h,i.gapSymbol),seq2Splitted:new Oe.Mu(d,i.gapSymbol)}}(c,u),d=yt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(bt(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>t),!0),r.shell.o=p.root}}class xt extends Ct{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new u.Subject;sampledIndices=null;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=a.Column.string(e,this.renderMolIds.length).init((e=>this.targetColumn?.get(this.renderMolIds[e])));t.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>t.setTag(e,this.targetColumn.getTag(e))));const n=a.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]}));const i=n.plot.grid();(0,Pe.Kd)(i,t.name,450,30),(0,Pe.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},((e,t)=>t)),this.sampledIndices=null);const n=this.distanceMetric,i=await dt(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map((e=>o[e])),a=new B(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),(e=>Math.min.apply(Math,i.map((function(t,n){return l[u(e,t)]})))));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map((e=>t[e]))}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var Mt,Et=n(5433),Tt=n(3890),_t=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M  RGP",e.ATOM_ALIAS_LINE_START="A  ",e.END="M  END"}(Mt||(Mt={}));class It{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Lt extends It{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Nt extends Lt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(Mt.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}}));const n=t.map(((e,t)=>{if(e.startsWith(Mt.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),i=n.map((e=>t[e])),o=n.map((e=>t[e+1]));i.forEach(((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)}));const r=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Mt.TYPE)&&-1!==e.indexOf(Mt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Mt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Mt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Mt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Mt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Mt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Mt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Pt extends Lt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M  V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M  END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M  V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Rt{constructor(){}static getInstance(e){if(Rt.isMolfileV2K(e))return new Nt(e);if(Rt.isMolfileV3K(e))return new Pt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Nt.isValidMolfile(e)}static isMolfileV3K(e){return Pt.isValidMolfile(e)}}var $t=n(6197),Ot=n(9124),kt=n(3527);class Ht{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Ht.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ft extends Ht{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Gt extends Ht{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Bt extends Ht{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Dt extends Ht{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Vt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{i[e.label]=e.capGroupName}));else{if(!r){if(t.lib)return new Dt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Vt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Wt={[Fe.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Fe.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Fe.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Fe.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Fe.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Fe.o.CHEM]:{R:"#eeeeee"},[Fe.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},Ut=/[\w()]+/,jt=RegExp(String.raw`\(${Ut}(,${Ut})+\)`),qt=e=>{const t=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,t,e),t},zt=new kt.Mi([255,255,255]),Yt=new kt.Mi([0,0,0]),Kt=.7*(0,K.wQ)(zt);class Zt{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new u.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length));for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t==ve._S||t===ve.b9[ve.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:R().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{_r.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,Ot.fA)(e,t),o=(0,$t.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Fe.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Fe.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===ve._S||"*"==i?s=r.wem=new Ft(n):n===Fe.o.NUCLEOTIDE&&"N"===i||n===Fe.o.AA&&"X"===i||(Fe.o.CHEM,0)||jt.test(i)?s=r.wem=new Gt(n,i):r.lib||(s=r.wem=new Bt(n,i,this.isEmpty)),s||(s=r.wem=Vt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,$t.Y)(e),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),r=this.getMonomer(n,t);if(r){const e=r.symbol,[t,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?qt(r.molfile):r.smiles?s.divV([qt(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=ve._S){let e=r.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(e))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${t}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new kt.Mi([...o.map((e=>e+1))]),s=(0,K.KE)(r,zt)/((0,K.wQ)(r)*(0,K.wQ)(zt)),l=i(n.backgroundcolor),c=new kt.Mi([...l.map((e=>e+.01))]);let u;u=(0,K.KE)(c,zt)/((0,K.wQ)(c)*(0,K.wQ)(zt))<s?l:o;let h=new kt.Mi(u);const d=(0,K.wQ)(h);return d>Kt&&(h=(0,K.dC)(Yt,h,Kt/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,$t.Y)(e),r=this.getMonomer(o,t);let s;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){_r.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(s=e[i])}if(!s){const t=Wt[e],n=t?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!s&&t)return this.getMonomerColors(e,t)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var Xt=n(5488),Jt={};Jt.styleTagTransform=S(),Jt.setAttributes=b(),Jt.insert=f().bind(null,"head"),Jt.domAPI=m(),Jt.insertStyleElement=w(),d()(Xt.A,Jt),Xt.A&&Xt.A.locals&&Xt.A.locals;class Qt extends Zt{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?.[n]??null}else{_r.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=(0,$t.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return i=i.filter((e=>null!==e)),0===i.length?[]:(i=i.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Rt.getInstance(t.molfile).atomTypes,i.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),i.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Le.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find((e=>e.lib?.source===o));r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of R().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}static overrideCounter=0;override(e,t){return new en(e,`override: ${++Qt.overrideCounter}, ${t}`,this)}}class en extends Zt{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class tn{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,o){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,we.AP)(e);this.error=t,this.monomers=[]}}}class nn{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var on=n(7433),rn=n.n(on),sn=n(1913),an=n.n(sn);class ln{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(rn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});an()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}var cn=n(8604);class un{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(e,t,n,i){let o;this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i;let r=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((e=>o=e))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),r||(r=!0,o())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++un.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await r.dapi.files.readAsText(cn.gt),o=JSON.parse(i),s=new ln(o);return new un(s,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await r.dapi.files.exists(cn.so+`${t}`))return void r.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await r.dapi.files.writeAsText(cn.so+`${t}`,e),await this.updateValidLibList(),await r.dapi.files.exists(cn.so+`${t}`)?r.shell.info(`Added ${t} HELM library`):r.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),r.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await r.dapi.files.delete(cn.so+`${e}`),await this.updateValidLibList(),r.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await r.dapi.files.exists(cn.so+`${e}`)?r.shell.error(`Failed to delete ${e} library`):r.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),o=await i.readAsText(t);n=JSON.parse(o);const r={},s=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;s.includes(t)||(r[t]={},s.push(t)),r[t][n]=e})),new Qt(r,t)}async loadSetFromFile(e,t,n){let i={};const o=new a.FileSource(t),r=await o.readAsText(n);i=JSON.parse(r);const s=i.description,l=Object.entries(i.placeholders).map((([t,n])=>{const i=t,o=n.polymerType,r=n.monomerType,s=n.set;return new tn(e,i,o,r,s)}));return new nn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await r.dapi.files.readAsText(cn.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${cn.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return _r.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{_r.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void _r.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await r.dapi.files.readAsText(cn.Es+`${e}`):t.push(e);const i=n.filter((e=>!t.includes(e)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),_r.logger.debug(`${e}, OUT`)})),_r.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(cn.so).then((e=>e.filter((e=>e.isFile)).map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(cn.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(cn.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(cn.Es.length)))}}class hn{constructor(){}static _instance;static getInstance(){return hn._instance||(hn._instance=new hn),hn._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,k.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class dn{logger;_monomerLib=new Qt({},"MAIN");_monomerSets=new nn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Qe.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++dn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return dn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const e=await un.create(this,this._eventManager,this.logger);return await e.initializedPromise,e})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,Le.ub)()]),o=t.filter((e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n}));let r=0;const s=o.length,[a]=await Promise.all([Promise.all(o.map((e=>this.readLibrary(cn.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Qt({},e,n)})).finally((()=>{n.update(Math.round(100*++r/s),`Loading monomers ${r}/${s}`)})))))]);this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let i=0;const o=n.length,[r]=await Promise.all([Promise.all(n.map((t=>this.readSet(cn.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new nn("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++i/o),`Loading monomers ${i}/${o}`)})))))]);this._monomerSets.updateSets(r)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,Le.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,Le.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}async loadMonomerLibForTests(){await(0,Le.Eu)(cn.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new dn(_r.logger);return e._eventManager=hn.getInstance(),e})()),e}}var pn=n(1757),mn=n.n(pn),gn=n(3017),fn={};fn.styleTagTransform=S(),fn.setAttributes=b(),fn.insert=f().bind(null,"head"),fn.domAPI=m(),fn.insertStyleElement=w(),d()(gn.A,fn),gn.A&&gn.A.locals&&gn.A.locals;var yn=n(3151);class bn{constructor(e,t=[],n={}){this.onItemChanged=new u.Subject,this.onAddingItemChanged=new u.Subject,this.onItemAdded=new u.Subject,this.onItemRemoved=new u.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=s.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach((t=>{e[t]=this.addingItemInputs[t].value})),e}getItemDiv(e={},t){var n,i;const o=[],r={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):s.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),o.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==a.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),r[c.name]=u,u.onChanged.subscribe((()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})})),u.root.style.alignItems="center",l=u}let c=null;if(t)this.addingItemInputs=r,c=s.icons.add((()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(r).forEach((t=>{e[t]=r[t].value})),this._items.push(e),this.onItemAdded.next(e),this.render()}),this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=s.icons.delete((()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()}),this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const vn={A:new U.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new U.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new U.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new U.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new U.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new U.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new U.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new U.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new U.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new U.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new U.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new U.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new U.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new U.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new U.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new U.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new U.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},wn={RNA:{A:new U.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new U.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new U.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new U.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new U.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:vn};async function Cn(e,t,n=0){if(!Object.keys(wn).includes(t))return null;const i=await async function(e){const t=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new U.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!wn[t])return null;const o=wn[t];let r=0,s=null;for(const[e,t]of Object.entries(o)){const o=(0,H.$1)(i,t);o>r&&o>=n&&(r=o,s=e)}return s}var Sn,An=n(857),xn={};xn.styleTagTransform=S(),xn.setAttributes=b(),xn.insert=f().bind(null,"head"),xn.domAPI=m(),xn.insertStyleElement=w(),d()(An.A,xn),An.A&&An.A.locals&&An.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(Sn||(Sn={}));const Mn={[Sn.MONOMER]:a.COLUMN_TYPE.STRING,[Sn.SYMBOL]:a.COLUMN_TYPE.STRING,[Sn.NAME]:a.COLUMN_TYPE.STRING,[Sn.R_GROUPS]:a.COLUMN_TYPE.STRING,[Sn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Sn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Sn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Sn.AUTHOR]:a.COLUMN_TYPE.STRING,[Sn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Sn.ID]:a.COLUMN_TYPE.INT,[Sn.META]:a.COLUMN_TYPE.STRING,[Sn.SOURCE]:a.COLUMN_TYPE.STRING};class En{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Sn.NAME).width=100,this.tv.grid.col(Sn.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=yn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new Nn(e,(()=>this.activeMonomerLib),(async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout((()=>{const n=t.col(Sn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const e=await dn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.instance=new En(e)}return this.instance}static async getNewInstance(){const e=await dn.getInstance();return await e.awaitLoaded(),await e.loadLibrariesPromise,new En(e)}async createNewMonomerLib(e,t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(t.map((e=>({...e,lib:void 0,wem:void 0}))),null,2);e.endsWith(".json")||(e+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,e),await r.dapi.files.writeAsText(cn.so+e,n),await this.monomerLibManamger.loadLibraries(!1),r.shell.v=await this.getViewRoot(e)}catch(e){r.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);o.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const t=i(n.value);if(t)r.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){r.shell.error("Error creating library"),console.error(e)}o.close()}})).show();o.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this.tv.subs.push(r.events.onContextMenu.subscribe((({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",(async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))})),e.menu.item("Fix all monomers",(()=>{this.fixAllMonomers()})),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",(async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>kn(this.tv.dataFrame.rows.get(e)))));this._newMonomerForm.removeMonomers(e,this.libInput.value)})),e.menu.item("Selection To New Library",(async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>kn(this.tv.dataFrame.rows.get(e)))));this.createNewLibDialog(e)}))):e.menu.item("Remove Monomer",(async()=>{const e=await kn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter((e=>e.name===En.VIEW_NAME)).forEach((e=>e.close()))}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(r.shell.tableViews??[]).find((e=>e.id===this.tv.id));return e?r.shell.v=e:En.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){r.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach(((e,t)=>{i[t]=e.filter((e=>0!==e.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((e=>e.length>0));const o=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.iconFA("wand-magic",(()=>{this.fixAllMonomers()}),"Fix all monomers"),c=s.icons.edit((async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),u=s.icons.delete((async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map((e=>kn(this.tv.dataFrame.rows.get(e)))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await kn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(u,(()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer"));const h=s.iconFA("arrow-to-bottom",(async()=>{const e=this.libInput.value;if(!e)return r.shell.error("No library selected");let t=null;try{t=await r.dapi.files.readAsText(cn.so+e)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return r.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")}),"Download Monomer Library");i.push([o,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=En.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}async editMonomer(e){return this._newMonomer=await kn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{return e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(cn.so,e),this.activeMonomerLib?function(e){try{const t=e.getPolymerTypes().flatMap((t=>e.getMonomerSymbolsByType(t).map((n=>e.getMonomer(t,n))))),n=a.DataFrame.create(t.length),i=new Set;for(const e of t)e.rgroups.forEach((e=>{e.label&&i.add(e.label)}));const o=Array.from(i);o.sort();for(const[e,t]of Object.entries(Mn))if(n.columns.addNew(e,t),e===Sn.R_GROUPS)for(const e of o)n.columns.addNew(e,a.COLUMN_TYPE.STRING);n.col(Sn.SYMBOL).semType="Monomer",n.col(Sn.SYMBOL).setTag(Re.Mn.applyToBackground,"true");for(let e=0;e<t.length;e++){let i=Rn(t[e].rgroups,t[e].smiles,t[e].molfile);i=Tn(i),t[e].rgroups=Ln(t[e].rgroups);const r=o.map((n=>{const i=t[e].rgroups.find((e=>e.label===n));return i?In(i,"capGroupSmiles"):""}));let s=null;if(t[e].createDate)try{s=Date.parse(t[e].createDate)}catch(n){console.error(`Error parsing date ${t[e].createDate}`)}n.rows.setValues(e,[i,t[e].symbol,t[e].name,JSON.stringify(t[e].rgroups??[]),...r,t[e].monomerType,t[e].polymerType,t[e].naturalAnalog,t[e].author,s,t[e].id,JSON.stringify(t[e].meta??{}),t[e].lib?.source??""]);try{s&&n.col(Sn.CREATE_DATE)?.set(e,s,!1)}catch(n){console.error(`Error setting date ${t[e].createDate}`,n)}}return n.col(Sn.MONOMER).semType=a.SEMTYPE.MOLECULE,o.forEach((e=>{n.col(e).semType=a.SEMTYPE.MOLECULE})),n}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}}(this.activeMonomerLib):(r.shell.error(`Library ${e} not found`),a.DataFrame.create())}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK((async()=>{const e=this.tv?.dataFrame;let t=this.libInput.value;if(e&&t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await Promise.all(new Array(e.rowCount).fill(0).map(((t,n)=>kn(e.rows.get(n))))),i=JSON.stringify(n.map((e=>({...e,lib:void 0,wem:void 0}))),null,2);t.endsWith(".json")||(t+=".json"),await r.dapi.files.writeAsText(cn.so+t,i),await this.monomerLibManamger.loadLibraries(!0),r.shell.v=await this.getViewRoot(t)}catch(e){r.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")})).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function Tn(e){let t=e.replaceAll(/\[R[1-9]\]/g,(e=>`[*:${e[2]}]`));return t=t.replaceAll(/\[\d\*\]/g,(e=>`[*:${e[1]}]`)),t.replaceAll(/\[\d\*\:\d\]/g,(e=>`[*:${e[1]}]`))}const _n=["alternateId","capGroupName","capGroupSMILES","label"];function In(e,t){const n=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));if(n)return e[n]}function Ln(e){return e.map((e=>{const t=function(e,t){const n={};return e.forEach((e=>{const i=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));i&&(n[e]=t[i])})),n}(_n,e),n=In(t,"capGroupSMILES"),i=In(t,"alternateId"),o=In(t,"capGroupName"),r=In(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t})).sort(((e,t)=>e.label?.localeCompare(t.label??"")??0))}class Nn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Hn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const e=this.validateInputs();e?r.shell.warning(e):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=Rn([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((e=>e[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((e=>Number.parseInt(e[0].match(/[1-9]/g)[0]))).map((e=>this.rgroupsGrid.items.find((t=>t.label===`R${e}`))??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`}));this.rgroupsGrid.items=i.sort(((e,t)=>e.label?.localeCompare(t.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Cn(On(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new bn(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?r.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new bn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Ln(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter((([e,t])=>"colors"!==e?.toLowerCase())).map((([e,t])=>({Property:e,Value:t}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&Cn(On(e.smiles,this.rgroupsGrid.items),e.polymerType).then((e=>{e&&(this.monomerNaturalAnalogInput.value=e)}));const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=s.buttonsInput([this.saveButton]);return s.tooltip.bind(e,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=Rn(e.rgroups,e.smiles,e.molfile),n=r.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await r.dapi.files.readAsText(cn.so+t);i=JSON.parse(e)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}const o=e.map((e=>Pn(i,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType))));for(let n=0;n<o.length;n++)if(-1===o[n])return void r.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=o.map((e=>i[e])),l=s.divV(a.map((e=>this.getMonomerInfoTable(e))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,u=c?`Are you sure you want to remove monomers ${a.map((e=>e.symbol)).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,h=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(u)).add(l).addButton("Remove",(async()=>{i=i.filter((e=>!a.includes(e))),await r.dapi.files.writeAsText(cn.so+t,JSON.stringify(i,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${c?"s":""} ${a.map((e=>e.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),h.close()})).show()}async addMonomerToLib(e,t){let n=[];try{const e=await r.dapi.files.readAsText(cn.so+t);n=JSON.parse(e)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}const i=Pn(n,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType)),o=this.getMonomersDataFrame()?.col(Sn.MONOMER)?.toList()?.findIndex((t=>t===e.smiles)),a=async()=>{try{const i=n.findIndex((t=>t.symbol===e.symbol&&t.polymerType===e.polymerType));i>=0?n[i]={...e,lib:void 0,wem:void 0}:n.push({...e,lib:void 0,wem:void 0}),await r.dapi.files.writeAsText(cn.so+t,JSON.stringify(n,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(e.symbol),this._molChanged=!1,r.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){r.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((o??-1)>=0){const e=await kn(this.getMonomersDataFrame().rows.get(o));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{e.close(),a()})).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!r.chem.checkSmiles(e))return void r.shell.warning("Invalid SMILES");e=Rn([],e);let t=r.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=$n(t);const n={};this.metaGrid.items.filter((e=>!!e.Property&&!!e.Value)).forEach((e=>{n[e.Property]=e.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function Pn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function Rn(e,t,n){const i=!t||!r.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return o=function(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(e=>`[*:${e[1]}]`)),n}(o,e),o=Tn(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function $n(e){const t=e.split("\n"),n=t.findIndex((e=>e.startsWith("M")&&e.includes("ISO")));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex((e=>e.includes("V2000")));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map((e=>e.trim())).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex((e=>e.startsWith("M")&&e.includes("RGP")))){const e=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map((([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`)).join("")}`,n=t.findIndex((e=>e.startsWith("M")&&e.includes("END")));t.splice(n,0,e)}return s.filter((e=>!!Number.parseInt(e))).map((e=>Number.parseInt(e)+i)).forEach((e=>{const n=t[e].split(" "),i=n.findIndex((e=>"R#"===e));if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}})),t.join("\n")}function On(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=In(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)})),n}async function kn(e){let t;try{t=JSON.parse(e.get(Sn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==a.INT_NULL.toString()&&t[e]!==a.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==a.INT_NULL&&t[e]!==a.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(Sn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=$n(i)}catch(e){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let o=e.get(Sn.NATURAL_ANALOG);const s=e.get(Sn.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(e.get(Sn.R_GROUPS)??"[]"),!o&&s){const e=await Cn(On(n,l),s);e&&(o=e)}}catch(e){l??=[]}return{symbol:e.get(Sn.SYMBOL),name:e.get(Sn.NAME),molfile:i,smiles:n,polymerType:s,monomerType:e.get(Sn.MONOMER_TYPE),naturalAnalog:o,id:e.get(Sn.ID),rgroups:l,meta:t,author:e.get(Sn.AUTHOR),createDate:e.get(Sn.CREATE_DATE)}}class Hn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:s.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:s.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:s.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Fn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Gn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map((e=>new Fn(e)));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,e),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach((e=>{e.root.onclick=()=>{this.monomerCards.forEach((e=>e.selected=!1)),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)}))}render(){this.monomerCards.forEach((e=>e.render()))}}class Bn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Bn._instance||(Bn._instance=new Bn,await Bn._instance.refresh(),(await dn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Bn._instance.refresh()))),Bn._instance.refresh(),Bn._instance}async refresh(){this.settings=await(0,Le.ub)();const e=await dn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,o=i?this.monomers[t][n].find((e=>e.lib?.source===i))??null:null;this.monomerCardRows.push(new Gn(n,this.monomers[t][n],o,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Le.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))}))})))}const t=s.divText("Set Default");if(t.addEventListener("click",(async()=>{if(0===Object.keys(this.monomers??{}).length)return void r.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void r.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=s.input.choice("Default Library",{items:n,nullable:!0});s.dialog("Set Default Monomer Source for Duplicates").add(i).onOK((async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some((e=>e.lib?.source===i.value))&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Le.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout((()=>this.refresh()),100)}else r.shell.info("No library selected")})).show()})),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter((t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)))}}}constructor(){}get root(){return this._root}}async function Dn(){await jn.showDialog()}async function Vn(e=!0){return await qn.showView(e)}class Wn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Wn.instancePromise&&(Wn.instancePromise=(async()=>{const e=new Wn,t=await(0,ye.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Wn.instancePromise}static async reloadWidget(){const e=await Wn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,ye.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await Un.createControlsForm();return mn()(e).addClass("monomer-lib-controls-form"),setTimeout((()=>{e&&mn()(e)&&mn()(e).removeClass("ui-form-condensed")}),200),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){r.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Un{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([e,t])=>{this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){_r.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,ye.pj)().then((e=>e.getFileManager())),await(0,Le.ub)()]);return new Un(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=s.wideForm(e,void 0);return mn()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();mn()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;_r.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const o=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e))),a=s.icons.edit((async()=>{r.shell.v=await(await En.getInstance()).getViewRoot(e)}),"Edit monomer library");return s.tooltip.bind(o,`Delete ${e}`),i.addOptions(a),i.addOptions(o),_r.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,Le.Eu)(this.userLibSettings);const n=await(0,ye.pj)();await n.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),r.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class jn{constructor(){}static _instance;dialog;closeDialogSubject$=new u.Subject;static async showDialog(){jn._instance||(jn._instance=new jn,jn._instance.closeDialogSubject$.subscribe((()=>{jn._instance.dialog=void 0}))),jn._instance.dialog||(jn._instance.dialog=await jn._instance.getDialog()),jn._instance.dialog.show()}async getDialog(){const e=hn.getInstance(),t=(await Wn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});mn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class qn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=hn.getInstance(),n=(await Wn.getInstance()).widget,i=s.bigButton("Add",(()=>t.addLibraryFile()),"Upload new HELM monomer library"),o=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,o])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach((e=>e.unsubscribe())),this._view.detach(),this._view.close()}catch(e){}return this._view=a.View.fromRoot(l),this._view.name=qn.viewName,e&&r.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const e=Array.from(l.children).filter((e=>e.classList.contains("ui-box")));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`}),100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe((()=>{try{const e=qn._instance;e&&e._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}})))})),this._view}static async showView(e=!0){return qn._instance||(qn._instance=new qn),qn._instance._duplicateManager||(qn._instance._duplicateManager=await Bn.getInstance()),qn._instance.libManager||(qn._instance.libManager=await dn.getInstance()),e&&qn._instance._view&&Array.from(r.shell.views).find((e=>e.id&&e.id===qn._instance._view.id))?(r.shell.v=qn._instance._view,await qn._instance._duplicateManager.refresh(),qn._instance._view):(qn.closeExistingViews(),qn._instance.getView(e))}static closeExistingViews(){Array.from(r.shell.views).filter((e=>e.name===qn.viewName)).forEach((e=>e.close()))}async mergeSelectedLibs(){const e="Library with this name already exists",t=await dn.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=u(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=o.value;return e.endsWith(".json")||(e+=".json"),e}function u(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}o.addValidator(u),i.add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const e=c(),t=JSON.stringify(n),o=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await o.addLibraryFile(t,e,!1);const n=await(0,Le.ub)();n.exclude=l,await(0,Le.Eu)(n),await this.libManager.loadLibraries(!0),await Wn.reloadWidget()}catch(t){r.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var zn,Yn=function(e,t,n,i){return new(n||(n=Promise))((function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};class Kn{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((e=>Yn(this,void 0,void 0,(function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find((e=>e.text===t))})))),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=s.iconFA("home",(()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=r.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>Yn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,Kn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Yn(this,void 0,void 0,(function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,Qe.cb)(c));const u=s.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Yn(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Yn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),e.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return Yn(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return Yn(this,void 0,void 0,(function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Kn.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Yn(this,void 0,void 0,(function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Kn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(zn||(zn={}));var Zn=n(966),Xn=n(608),Jn=n(1619);class Qn{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=R()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${_r.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case it.n5.fixWidth:case it.n5.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ei{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ti=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ni="-";class ii extends De{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Re.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=r.cell.value;a&&a!==ve._S||(a=ni);const l=a.split(ve.ot).map((e=>e&&e!==ve._S?e.trim():ni)),c=l.map((e=>(0,ge.zS)(e,Math.max(2,Math.floor(.15*i/l.length))))),u=c.map((t=>e.measureText(t).width)),h=u.reduce(((e,t)=>e+t),0);let d=t+(i-h)/2;const p=this.tableCol.getTag(ve.gp.alphabet),m=p===ge.YI.RNA||p===ge.YI.DNA?ti.o.NUCLEOTIDE:ti.o.AA;for(let r=0;r<c.length;r++){const a=l[r];let h=$e.S$,p="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,a);h=e?.textcolor??h,p=e?.backgroundcolor??p}else h=this.monomerLib.getMonomerTextColor(m,a);s&&1==l.length&&(e.fillStyle=p,e.fillRect(t,n,i,o)),e.fillStyle=h,e.fillText(c[r],d,n+o/2,i),d+=u[r]}}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(ve.gp.alphabet),i=e.cell.value,o=e.grid.canvas.getBoundingClientRect(),r=e.bounds.right+o.left-4,a=e.bounds.bottom+o.top-4;if(!i||i==ve._S||i==ni)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===ge.YI.RNA||n===ge.YI.DNA?ti.o.NUCLEOTIDE:ti.o.AA,c=i.split(ve.ot).map((e=>e&&e!==ve._S&&e!==ni?this.monomerLib.getTooltip(l,e):s.divText("gap"))),u=s.divH(c,{style:{alignItems:"top"}}),h=Array.from(u.querySelectorAll("canvas"));if(h.length>2){const e=Math.floor(550/h.length);h.forEach((t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")}))}return s.tooltip.show(u,r,a),!0}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new ii(t,n)),o}}class oi extends a.GridCellRenderer{get name(){return Ve.uF.MONOMER}get cellType(){return Ve.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){ii.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){ii.getOrCreate(e).onMouseMove(e,t)}}class ri{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class si extends Map{_onPropertyChanged=new u.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class ai extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new ri(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,we.AP)(e);r.shell.error(t),this.logger.error(t,void 0,n)}}var li=n(5999),ci={};ci.styleTagTransform=S(),ci.setAttributes=b(),ci.insert=f().bind(null,"head"),ci.domAPI=m(),ci.insertStyleElement=w(),d()(li.A,ci),li.A&&li.A.locals&&li.A.locals;var ui=n(6307);class hi extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(e,t){super(s.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=_r.properties.tooltipWebLogo,n=this.seqCol.getTag(et.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function di(e,t,n,i){const o=_r.seqHelper.getSeqHandler(e);let r=null,s=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(s=e);if(null===r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(r,s,a)}const pi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ge.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class mi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??pi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ge.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ge.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${_r.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class gi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ge.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{_r.handleErrorUI(e)}))})).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=s.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{_r.handleErrorUI(e)}))}));return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var fi=n(8754);async function yi(e,t,n,i,o){const r=await async function(e,t,n,i,o){const r=(0,be.R)(t,o),s=o.getSeqHandler(t).getNewColumnFromList("ref",[n]),l=o.getSeqHandler(s).getSplitted(0),c=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):ve._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return s}(l,r):i===pe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList();return await(0,ye.uL)(i,e,n)}(l,r,o):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,i,o);for(let e=0;e<r.length;e++)t.isNone(e)&&r.set(e,null,!1);return r}var bi=n(294),vi=n(330);const wi=OCL;var Ci=n(2582);class Si{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var Ai=n(6956);class xi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const i=e[n-1];i===Ai.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)}))}}class Mi{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}}))}}class Ei extends Mi{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class Ti{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class _i extends Ti{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class Ii extends Si{constructor(e,t){super(t);const n=Rt.getInstance(e);this.atoms=new Ei(n),this.bonds=new _i(n),this.rGroups=new xi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Li extends Mi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,((e,t,n,i,o,a)=>t+r+i+s+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M  ${n.slice(0,7).join(" ")}`)}}class Ni extends Ti{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`))}))}}class Pi extends Si{constructor(e,t){super(t);const n=Rt.getInstance(e);this.atoms=new Li(n),this.bonds=new Ni(n),this.rGroups=new xi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ri{static getInstance(e,t){if(Rt.isMolfileV2K(e))return new Ii(e,t);if(Rt.isMolfileV3K(e))return new Pi(e,t);throw new Error("Unsupported molfile version")}}class $i{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;Rt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Ri.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if($i.molfileV2KToV3KCache.has(e))return $i.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return $i.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Oi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Ci.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===ve.b9[ge.Hi.HELM])return;const i=this.monomerWrappers.length,o=new $i(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),i=t.map((e=>this.monomerWrappers[e])),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers();const i=new bi.Cg;for(const[n,o]of R().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Fe.o.NUCLEOTIDE:Fe.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:R().count(r).take(n.atomCount).toArray(),bonds:R().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,o)=>t+i+o))})),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,o)=>t+i+o))})),"M  V30 END BOND"].join("\n")}}class ki{constructor(e){this.molfileHandler=Rt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Hi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map((e=>null===e?"":e)))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return wi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,we.AP)(e);return _r.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map((e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null})),s=`molfile(${e.name})`,l=o?o.columns.getUnusedName(s):s;return t?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map((e=>e.molfile)),i=(0,vi.kA)(t,`molfileV3K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=bi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,we.AP)(e);_r.logger.error(t,void 0,n),o=bi.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new ki(o),s=new Oi(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach(((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)}));const a=s.compileToMolfile(),l=new bi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new bi.vF(a.molfile,l)}}class Fi{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[We.notationProvider]??null);const i=this.isFasta()?ve.b9[ge.Hi.FASTA]:this.isSeparator()?ve.b9[ge.Hi.SEPARATOR]:this.isHelm()?ve.b9[ge.Hi.HELM]:this.isCustom()?this.notationProvider?.defaultGapOriginal??ve.b9[ge.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ge.gp.aligned)||!this.column.tags.has(ge.gp.alphabet)||!this.column.tags.has(ge.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ge.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ge.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(ge.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ge.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ge.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||this.isCustom()&&this.notationProvider||e.temp.seqHandlerRefined||(this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null===r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?R().count(0).take(Math.min(100,this.column.length)).map((e=>this.column.get(e))):this.column.categories.slice(0,100)).map((e=>e?e.substring(0,500):"")).filter((e=>0!==e.length)))],0,(e=>e.split(this.separator)));let t=!1;const n=[{package:"SequenceTranslator",name:"refineNotationProviderForHarmonizedSequence"}];for(const i of n)try{const n=a.Func.find(i);if(0===n.length)continue;const o=n[0].prepare({col:this.column,stats:e,separator:this.separator}),r=(await o.call()).getOutputParamValue();t||=r}catch(e){console.error(e)}t&&(delete this.column.temp[We.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ge.Hi.FASTA,ge.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ge.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ge.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ge.gp.aligned,t));let n=e.column.getTag(ge.gp.alphabet);if(null===n&&(n=(0,Oe.pc)(e.stats.freq,ge.q7),e.column.setTag(ge.gp.alphabet,n)),n===ge.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(ge.gp.alphabetSize,t.toString()),e.column.setTag(ge.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ge.Hi.HELM){let t=e.column.getTag(ge.gp.alphabet);null===t&&(t=(0,Oe.p0)(e.stats.freq,ge.q7,e.defaultGapOriginal),e.column.setTag(ge.gp.alphabet,t))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ge.gp.separator)??void 0;if(this.notation===ge.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ge.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ge.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ge.YI.RNA||this.alphabet===ge.YI.DNA?Fe.o.NUCLEOTIDE:Fe.o.AA}get helmCompatible(){return this.column.getTag(ge.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ge.Hi.HELM||this.alphabet==ge.YI.UN){const e=this.column.getTag(ge.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ge.YI.PT:return 20;case ge.YI.DNA:case ge.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ge.Hi.HELM||this.alphabet===ge.YI.UN&&"true"===this.column.getTag(ge.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===ve.b9[ge.Hi.FASTA]?ve._S:i??ve._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(ve._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===ve.b9[ge.Hi.FASTA]?ve._S:o??ve._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new Ue(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ge.Hi.HELM?n:this.notation===ge.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(ge.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ge.YI.DNA||e===ge.YI.RNA||e===ge.YI.PT}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:R().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)).reduce(((e,t)=>e>t?e:t),0)),this._maxLength}_posList=null;get posList(){if(null===this._posList){const e=this.column.getTag(ge.gp.positionNames);this._posList=e?e.split(ge.z1).map((e=>e.trim())):R().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===ge.Hi.FASTA}isSeparator(){return this.notation===ge.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ge.Hi.HELM}isCustom(){return this.notation===ge.Hi.CUSTOM}isRna(){return this.alphabet===ge.YI.RNA}isDna(){return this.alphabet===ge.YI.DNA}isPeptide(){return this.alphabet===ge.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return ge.Hi.FASTA;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return ge.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.Hi.HELM;if(this.units.toLowerCase().startsWith(ge.Hi.CUSTOM))return ge.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ge.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ge.Hi.SEPARATOR}' requires separator value.`);l.setTag(ge.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===ge.Hi.HELM?"helm":"sequence");const c=o.getTag(ge.gp.aligned);c&&l.setTag(ge.gp.aligned,c);let u=o.getTag(ge.gp.alphabet);u||this.notation!==ge.Hi.HELM||e===ge.Hi.HELM||(u=ge.YI.UN),null!=u&&l.setTag(ge.gp.alphabet,u);let h=o.getTag(ge.gp.alphabetSize);null!=u&&h&&l.setTag(ge.gp.alphabetSize,h);const d=o.getTag(ge.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ge.gp.alphabetIsMultichar,d),e==ge.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ge.gp.alphabetSize,h)),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!Fi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return null===this.column.getTag(ge.gp.alphabet)||this.getAlphabetIsMultichar()?ge.J9:Oe.tm;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return(0,ge.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return me.Z.HAMMING;switch(this.alphabet){case ge.YI.DNA:case ge.YI.RNA:case ge.YI.PT:}return me.Z.LEVENSHTEIN}getDistanceFunction(){return me.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ge.gp.isHelmCompatible))return"true"===this.column.getTag(ge.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ge.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ge.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ge.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ge.Hi.FASTA}toSeparator(e){return e===ge.Hi.SEPARATOR}toHelm(e){return e===ge.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?ve.b9[ge.Hi.FASTA]:ve.b9[ge.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ge.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(yn.EK,"$1")),n===ve.b9[ge.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init((e=>{const t=this.getSplitted(e);return n(t)})),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=ve.b9[this.notation];i.init((e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new Oe.Mu(n,l))}));const c=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ge.z1)},u=this.column.getTag(ge.gp.positionNames);u&&i.setTag(ge.gp.positionNames,c(u));const h=this.column.getTag(ge.gp.positionLabels);return h&&i.setTag(ge.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ge.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ge.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Gi(e,n,o.isHelm())};break;case ge.Hi.HELM:{const e=o.alphabet===ge.YI.DNA||o.alphabet===ge.YI.RNA,t=o.getHelmWrappers();i=function(n){return Bi(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ge.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ge.Hi.SEPARATOR}'.`);const n=this;if(e===ge.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ge.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ge.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e,t){let n=e.temp[We.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[We.seqHandler]=new Fi(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(yn.EK,"$1")),o===ve._S?r=ve.b9[ge.Hi.FASTA]:o===yn.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Gi(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ge.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return Bi(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(yn.EK,"$1"),r=r===yn.q7?null:r),n[e]=r||null}return new Oe.Mu(n.filter((e=>!!e)),ve.b9[ge.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(e,t)),i}}function Gi(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(yn.EK,"$1")),o===ve._S?r=ve.b9[ge.Hi.SEPARATOR]:o===yn.q7&&(r=""),i[t]=r}return i.join(t)}function Bi(e,t,n){const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=e.getOriginal(t);i===ve._S?s=ve.b9[ge.Hi.HELM]:(n&&(s=s.replace(yn.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}class Di{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return Fi.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Ot.b2)();return new Hi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return bi.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return bi.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return bi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new bi.vF(e,o.monomers)}catch(e){const[t,n]=(0,we.AP)(e);return _r.logger.error(t,void 0,n),bi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const o=i??this.libHelper.getMonomerLib(),s=e.dataFrame,l=(0,vi.qj)(s,e.name),c=await this.getHelmToMolfileConverter(o),u=e.toList(),h=new Array(e.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!p,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&p){const t=await p.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,h);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",e.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.FASTA)throw new Error(`The column of notation '${ge.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ge.Hi.FASTA,Fi.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.SEPARATOR)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ge.Hi.SEPARATOR,e.column.setTag(ge.gp.separator,t),Fi.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ge.Hi.HELM,Fi.setTags(e)}}async function Vi(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};if(![ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].includes(e.cell.column.meta.units?.toLowerCase()??""))return t="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:t,mol:""};const n=(await Lr.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,50)?.length??100)>40)return t="Maximum number of monomers is 40",{errorText:t,mol:""};const i=a.Column.fromStrings("singleVal",[e.value]),o=a.DataFrame.fromColumns([i]);if(Object.entries(e.cell.column.tags).forEach((([e,t])=>{i.setTag(e,t)})),await Lr.toAtomicLevel(o,i,e.cell.column.meta.units===ge.Hi.HELM,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const r=o.columns.byIndex(1).get(0);return r?{errorText:"",mol:r}:(t="No structure generated",{errorText:t,mol:""})}catch(e){_r.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const Wi="#333333",Ui="rgba(60, 177, 115, 0.1)",ji="rgba(240, 240, 240, 0.5)",qi="rgba(100, 100, 100, 0.3)";class zi{constructor(e=Zi.DEFAULT_TRACK_HEIGHT,t=Zi.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class Yi extends zi{constructor(e=new Map,t=Zi.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,Zi.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator(((e,t,n)=>this.createTooltipContent(e,t,n)))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=Fe.o.NUCLEOTIDE;break;default:t=Fe.o.AA}const n=Array.from(e.values()).reduce(((e,t)=>e+t),0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,ui.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(s.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(s.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(s.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort(((e,t)=>t[1]-e[1])),s=r.reduce(((e,[t,n])=>e+n),0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const p=t+e*s,m=s-2;r+e===l&&(this.ctx.fillStyle=Ui,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=ji,this.ctx.fillRect(p+1,c,m,u),this.drawLettersInColumn(h,p,m,c,u,d),this.drawColumnBorder(p,c,m,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort(((e,t)=>t[1]-e[1])),a=s.reduce(((e,[t,n])=>e+n),0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=qi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=a.Color.fromHtml(t),n=a.Color.getContrastColor(e);return a.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class Ki extends zi{constructor(e,t=Zi.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,Zi.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=Ui,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=ji,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=qi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Wi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const Zi={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},Xi={BASE:Zi.DOTTED_CELL_HEIGHT+Zi.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+Zi.TITLE_HEIGHT+Zi.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP}};class Ji{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||Xi.BASE,sliderHeight:e.sliderHeight||Zi.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach((e=>{e.setVisible(!1),e.setHeight(Zi.DEFAULT_TRACK_HEIGHT)})),!(e<Xi.WITH_TITLE()||e<Xi.WITH_WEBLOGO()))if(e<Xi.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-Xi.WITH_WEBLOGO();t.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>Xi.WITH_BOTH()){const n=e-Xi.WITH_BOTH();t.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach(((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)})),e<Xi.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<Xi.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=Xi.WITH_TITLE()?(Zi.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=Xi.WITH_WEBLOGO();else{if("conservation"!==e)return;t=Xi.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach(((e,t)=>{this.userSelectedTracks[t]=!1}))),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame((()=>this.redraw()))}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?Xi.WITH_BOTH():Xi.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame((()=>this.redraw()))}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=Xi.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,Zi.TITLE_HEIGHT),this.ctx.fillStyle=Wi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+Zi.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach((e=>{e instanceof Yi&&e.setHovered(-1,null)})),window.requestAnimationFrame((()=>this.redraw())))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,l=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,c=l-Zi.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let g=c;for(const{id:e,track:t}of d){const i=g-t.getHeight();if(n>=i&&n<g){u=e,h=n-i;break}g=i-Zi.TRACK_GAP}let f=null;if(u){const e=this.tracks.get(u);e&&(f=e.getMonomerAt(t,h,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==u||this.previousHoverMonomer!==f)&&(this.previousHoverPosition=r,this.previousHoverTrack=u,this.previousHoverMonomer=f,u)){const e=this.tracks.get(u);e instanceof Yi&&(e.setHovered(r,f),window.requestAnimationFrame((()=>this.redraw())))}if((r!==this.currentHoverPosition||u!==this.currentHoverTrack||f!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=u,this.currentHoverMonomer=f,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(r,f);if(n)return void s.tooltip.show(n,e.clientX+16,e.clientY+16)}}u&&f||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame((()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=Xi.WITH_TITLE();l&&Zi.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-Zi.SLIDER_HEIGHT,u=c-Zi.DOTTED_CELL_HEIGHT,h=u-Zi.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const g=this.getTrack("conservation");g&&g.isVisible()&&p.push({id:"conservation",track:g});let f=h;for(const{track:e}of p){const t=e.getHeight(),i=f-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),f=i-Zi.TRACK_GAP}if(this.drawDottedCells(0,u,n,Zi.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:Zi.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+Zi.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,p=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Wi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,Zi.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,Zi.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,Zi.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-Zi.SLIDER_HEIGHT;return t>n&&t<n+Zi.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-Zi.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+Zi.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",(e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")})),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,a=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,l=a-Zi.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&h.push({id:"conservation",track:p});let m=l;for(const{id:e,track:t}of h){const i=m-t.getHeight();if(n>=i&&n<m){c=e,u=n-i;break}m=i-Zi.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init((e=>i[e]===t))}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach((t=>t.init(e)))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=Xi.WITH_TITLE()&&t&&(Qi(e.left??0,n,i)||Qi(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-Zi.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:Xi.BASE,WITH_TITLE:Xi.WITH_TITLE(),WITH_WEBLOGO:Xi.WITH_WEBLOGO(),WITH_BOTH:Xi.WITH_BOTH()}}}function Qi(e,t,n){return e>=t&&e<=n}class eo{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){eo.conservationCache=new a.LruCache(100),eo.webLogoCache=new a.LruCache(100),eo.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return eo.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return eo.conservationCache.getOrCreate(i,(()=>{const o=eo.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r}))}static getWebLogoChunk(e,t,n,i){return eo.webLogoCache.getOrCreate(i,(()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o}))}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/eo.CHUNK_SIZE)*eo.CHUNK_SIZE,s=Math.ceil(n/eo.CHUNK_SIZE)*eo.CHUNK_SIZE;for(let t=r;t<s;t+=eo.CHUNK_SIZE){const n=Math.min(t+eo.CHUNK_SIZE,i),r=eo.getChunkCacheKey(e.column,t,n),s=eo.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/eo.CHUNK_SIZE)*eo.CHUNK_SIZE,s=Math.ceil(n/eo.CHUNK_SIZE)*eo.CHUNK_SIZE;for(let t=r;t<s;t+=eo.CHUNK_SIZE){const n=Math.min(t+eo.CHUNK_SIZE,i),r=eo.getChunkCacheKey(e.column,t,n),s=eo.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class to extends Yi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=eo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=eo.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class no extends Ki{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=eo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=eo.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}async function io(){return Lr.getMonomerLibHelper()}async function oo(){return Lr.initBio()}function ro(e){return Lr.sequenceTooltip(e)}function so(){return Lr.getBioLib()}function ao(e){return Lr.getSeqHandler(e)}function lo(e){return Lr.getRegionPanel(e)}async function co(e){return Lr.libraryPanel(e)}function uo(e){return Lr.GetRegionEditor(e)}function ho(e){return Lr.SplitToMonomersEditor(e)}function po(e){return Lr.SequenceSpaceEditor(e)}function mo(e){return Lr.SeqActivityCliffsEditor(e)}function go(){return Lr.customSequenceCellRenderer()}function fo(){return Lr.fastaSequenceCellRenderer()}function yo(){return Lr.separatorSequenceCellRenderer()}function bo(e){return Lr.macroMolColumnPropertyPanel(e)}function vo(e){return Lr.compositionAnalysisWidget(e)}function wo(){return Lr.macromoleculeDifferenceCellRenderer()}function Co(e,t,n,i,o){return Lr.sequenceAlignment(e,t,n,i,o)}function So(){return Lr.webLogoViewer()}function Ao(){return Lr.vdRegionsViewer()}function xo(e,t,n,i){return Lr.getRegion(e,t,n,i)}async function Mo(e,t,n,i,o){return Lr.getRegionTopMenu(e,t,n,i,o)}async function Eo(e,t,n,i,o,r,s,a,l){return Lr.activityCliffs(e,t,n,i,o,r,s,a,l)}async function To(e,t,n,i,o){return Lr.macromoleculePreprocessingFunction(e,t,n,i,o)}async function _o(e,t){return Lr.helmPreprocessingFunction(e,t)}async function Io(e,t,n,i,o,r,s,a,l){return Lr.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function Lo(e,t,n,i){return Lr.toAtomicLevel(e,t,n,i)}async function No(e){return Lr.toAtomicLevelAction(e)}async function Po(e){return Lr.toAtomicLevelPanel(e)}async function Ro(e){return Lr.sequence3dStructureWidget(e)}function $o(){return Lr.multipleSequenceAlignmentDialog()}async function Oo(e,t,n){return Lr.alignSequences(e,t,n)}async function ko(){return Lr.compositionAnalysis()}function Ho(e){return Lr.importFasta(e)}function Fo(e){return Lr.importBam(e)}function Go(){return Lr.convertDialog()}function Bo(e){return Lr.convertColumnAction(e)}function Do(){return Lr.monomerCellRenderer()}async function Vo(e){return Lr.testDetectMacromolecule(e)}async function Wo(e,t){return Lr.splitToMonomersTopMenu(e,t)}function Uo(e){return Lr.getHelmMonomers(e)}function jo(){return Lr.similaritySearchViewer()}function qo(){return Lr.similaritySearchTopMenu()}function zo(){return Lr.diversitySearchViewer()}function Yo(){return Lr.diversitySearchTopMenu()}function Ko(e){return Lr.searchSubsequenceEditor(e)}function Zo(e){return Lr.SubsequenceSearchTopMenu(e)}async function Xo(e,t,n){return Lr.sequenceIdentityScoring(e,t,n)}async function Jo(e,t,n){return Lr.sequenceSimilarityScoring(e,t,n)}async function Qo(){return Lr.manageMonomerLibraries()}async function er(){return Lr.manageLibrariesView()}async function tr(){return Lr.manageMonomersView()}async function nr(){return Lr.manageMonomerLibrariesView()}async function ir(e,t){return Lr.manageMonomerLibrariesViewTreeBrowser(e,t)}function or(){return Lr.saveAsFasta()}function rr(){return Lr.bioSubstructureFilter()}function sr(){return Lr.bioSubstructureFilterTest()}async function ar(){return Lr.webLogoLargeApp()}async function lr(){return Lr.webLogoAggApp()}async function cr(){return Lr.getRegionApp()}async function ur(){return Lr.getRegionHelmApp()}function hr(){return Lr.longSeqTableSeparator()}function dr(){return Lr.longSeqTableFasta()}function pr(){return Lr.longSeqTableHelm()}function mr(e,t){return Lr.addCopyMenu(e,t)}async function gr(){return Lr.demoBioSimilarityDiversity()}async function fr(){return Lr.demoBioSequenceSpace()}async function yr(){return Lr.demoBioActivityCliffs()}async function br(){return Lr.demoBioAtomicLevel()}async function vr(e){return Lr.sdfToJsonLib(e)}async function wr(e,t){return Lr.seq2atomic(e,t)}async function Cr(e,t){return Lr.seqIdentity(e,t)}async function Sr(e,t,n){return Lr.detectMacromoleculeProbe(e,t,n)}async function Ar(){return Lr.getSeqHelper()}async function xr(e,t,n){return Lr.getMolFromHelm(e,t,n)}var Mr=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},Er=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Tr=function(e,t){return function(n,i){t(n,i,e)}};const _r=new ai;let Ir=null;class Lr{static async getMonomerLibHelper(){return await dn.getInstance()}static async initBio(){null===Ir&&(Ir=async function(){const e="Bio: _package.initBio()";_r.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Ne.j)(),i=await _r.getProperties(),o=new si(i);_r.properties=o;const s=await dn.getInstance(),l=await(0,Le.ub)();l.explicit&&(l.explicit=[],await(0,Le.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),h=s.getMonomerSets(),d=window.performance.now();_r.logger.debug(`${e}, loading ET: ${d-t} ms`);const p=new Di(s,n);_r.completeInit(p,c,h,n),_r.logger.debug(`${e}, end`),function(){const e=e=>{setTimeout((()=>{if(e.isDetached)return;const t=e.dataFrame;if(!t)return;const n=t.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let n=null;try{n=_r.seqHelper.getSeqHandler(i)}catch(e){continue}if(!n)continue;if(n.isHelm()||n.alphabet===ge.YI.UN)continue;const o=e.col(i.name);if(!o)continue;let s=!!e.tableView&&Array.from(e.tableView.viewers).some((e=>"Sequence Position Statistics"===e.type));if(n.isMsa()){const l=(e,t)=>Number.isNaN(e)?t:e,c=()=>l(Math.max(Number.parseInt(i.getTag(ge.gp.positionShift)??"0"),0),0)+1,h=()=>l(Number.parseInt(i.getTag(ge.gp.selectedPosition)??"-2"),-2),d=()=>$e.Jy.getFontSettings(i).fontWidth;let p=0,m=0;const g=i.categories;for(let e=0;e<g.length;e++){const t=g[e];t&&t.length>m&&(m=t.length,p=e)}const f=g[p],y=n.splitter(f),b=y?y.length:30,v={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let w;w=i.length>1e5||b<50?v.WITH_TITLE:i.length>5e4?v.WITH_WEBLOGO:v.WITH_BOTH;let C=null,S=null;const A=a.debounce(u.merge(t.onFilterChanged,t.onDataChanged.pipe((0,k.filter)((e=>e?.args?.column===i)))),100).subscribe((()=>{eo.clearAllCaches(),C&&(C.resetViewportTracking(),C.forceUpdate()),S&&(S.resetViewportTracking(),S.forceUpdate()),setTimeout((()=>{e.isDetached||e.invalidate()}),50)}));e.sub(A);const x=r=>{const l=[],u=new no(n,b,45,"default","Conservation");S=u,l.push({id:"conservation",track:u,priority:1});const p=new to(n,b,45,"WebLogo");C=p,r&&(p.setMonomerLib(r),p.setBiotype(n.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new Ji({canvas:e.overlay,headerHeight:w,totalPositions:b+1,onPositionChange:(t,n)=>{setTimeout((()=>{const o=c(),r=h();if(o!==n.start&&i.setTag(ge.gp.positionShift,(n.start-1).toString()),r!==t&&(i.setTag(ge.gp.selectedPosition,t.toString()),t>=0&&!s&&e.tableView&&R()(e.dataFrame?.columns.numerical).find((e=>!0)))){s=!0;const t=e.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:i.name});e.tableView.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}}))},onHeaderHeightChange:t=>{e.isDetached||t<v.WITH_TITLE||setTimeout((()=>e.props.colHeaderHeight=t))}},o);m.setupTooltipHandling(),l.forEach((({id:e,track:t})=>{m.addTrack(e,t)})),m.setSelectionData(t,i,n),b>50&&(e.props.colHeaderHeight=w,setTimeout((()=>{e.isDetached||(o.width=400)}),300)),e.sub(e.onCellRender.subscribe((e=>{const t=e.cell;if(!t||!t.isColHeader||t?.gridColumn?.name!==o?.name)return;const n=e.bounds;if(!n)return;m.headerHeight=n.height;const r=d();m.positionWidth=r+8;const s=c();m.draw(n.x,n.y,n.width,n.height,h(),s,e,i.name)})))};(0,ye.pj)().then((e=>{const t=e.getMonomerLib();x(t)})).catch((e=>{r.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)}))}}}),1e3)},t=(r.events.onViewerAdded.subscribe((t=>{if(!(t.args&&t.args.viewer instanceof a.Grid))return;const n=t.args.viewer;e(n)})),r.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await Ir}static sequenceTooltip(e){const t=new hi(e,_r.seqHelper);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();r.shell.error(t)})),t}static getBioLib(){return _r.monomerLib}static getSeqHandler(e){return _r.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=a.Func.find({package:_r.name,name:t});if(1!==n.length)throw new Error(`Package '${_r.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new gi(i,_r.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=s.label("Manage monomer libraries");return mn()(e).addClass("d4-link-action"),e.onclick=async()=>await Dn(),new a.Widget(e)}()}static GetRegionEditor(e){try{new gi(e,_r.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(`Get region editor error: ${t}`),_r.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new ei;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}static SequenceSpaceEditor(e){const t=new O({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}static SeqActivityCliffsEditor(e){const t=new Se({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}static customSequenceCellRenderer(){return new ze}static fastaSequenceCellRenderer(){return new ze}static separatorSequenceCellRenderer(){return new ze}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);let n=_r.properties?_r.properties.maxMonomerLength:4;if(Re.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Re.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout((()=>{i.value=null}),0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Ge.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=_r.properties?_r.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const r=s.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Ge.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Ge.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),u=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),h=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;(()=>{const t=e.meta.units;return t!==ge.Hi.HELM&&t!==ge.Hi.CUSTOM})()&&(d=s.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[r,i,l,u,c,h];d&&p.push(d);const m=s.inputs(p);return new a.Widget(m)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=s.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ge.gp.alphabet],r=o===ge.YI.DNA||o===ge.YI.RNA?Fe.o.NUCLEOTIDE:Fe.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u);R().count(0).take(h.length).filter((e=>!h.isGap(e))).forEach((e=>{let t=h.getCanonical(e);r===Fe.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;l[t]=n+1}));const d=(0,ui.F)(l,r,t);return Array.from(d.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),i.appendChild(d),new a.Widget(i)}(e,_r.monomerLib,_r.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new Ke}static sequenceAlignment(e,t,n,i,o){const r=new ht(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new it.oP}static vdRegionsViewer(){return new lt}static getRegion(e,t,n,i){return di(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,o){const s=di(t,n??null,i??null,o??null);t.dataFrame.columns.add(s),await r.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,o,u,h,d,p){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);if(!(0,Zn.V)(t,"Activity Cliffs"))return;const m=Ee(e),g={units:t.meta.units,aligned:t.getTag(ge.gp.aligned),separator:t.getTag(ge.gp.separator),alphabet:t.getTag(ge.gp.alphabet)},f=u,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,f,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,g,h,mt,gt,vt,void 0,p),v=o===c.c.UMAP?2e5:2e4,w=o===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void r.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),S=await new Promise(((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK((async()=>{b().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():b().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,we.AP)(e);throw _r.logger.error(t,void 0,n),e})).finally((()=>{C.close()}));return S?.props?.xColumnName&&S?.props?.yColumnName&&e.col(S.props.xColumnName)&&e.col(S.props.yColumnName)&&(e.col(S.props.xColumnName).set(0,e.col(S.props.xColumnName).get(0)),e.col(S.props.yColumnName).set(0,e.col(S.props.yColumnName).get(0))),S}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:s}=await dt(e,t,o,n,i);return{entries:r,options:s}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,pt.BQ)(e,_r.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await r.functions.call("Chem:getMorganFingerprints",{molColumn:n}),o=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);o[e]=U.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:o,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,o,s,c,u,h){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);const d=r.shell.tv.dataFrame==e?r.shell.tv:void 0;return(0,Zn.V)(t,"Sequence Space")?(s||(s=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await _e(e,[t],n,[i],[1],[s],"MANHATTAN",o,u??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[l.vb],tableView:d})):void 0}static async toAtomicLevel(e,t,n,i=!1){const o=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Ir;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??_r.monomerLib,r=_r.seqHelper,s=_r.rdKitModule;await(0,fi.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Vi(e);if(t.errorText||!t.mol)return a.Widget.fromRoot(s.divText(t.errorText??"No structure generated"));try{const e=a.SemanticValue.fromValueType(t.mol,a.SEMTYPE.MOLECULE),n=s.panels.infoPanel(e);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=r.chem.drawMolecule(t.mol,300,300,!1);return o.style.cursor="pointer",s.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=r.chem.drawMolecule(t.mol,e,n,!1);s.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(e){_r.logger.error(e)}return a.Widget.fromRoot(s.divText("No structure generated"))}(e)}static async sequence3dStructureWidget(e){return async function(e){const t=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Vi(e);if(o.errorText||!o.mol)return n=s.divText(o.errorText??"No structure generated"),t.close(),new a.Widget(n);const l=o.mol;i=await r.functions.call("Bio:Embed",{molecule:l});const c=wi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then((function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()})),n=s.div([t],{style:{aspectRatio:"1"}})}catch(e){n=s.divText("Couldn't get 3D structure")}}catch(e){n=s.divText("Couldn't get 3D structure")}return t.close(),new a.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,Jn.D)({},_r.seqHelper).catch((e=>{const[t,n]=(0,we.AP)(e);if(e instanceof Xn.Ap)return r.shell.warning(e.element),void _r.logger.warning(t);r.shell.error(t),_r.logger.error(t,void 0,n)}))}static async alignSequences(e=null,t=null,n){return(0,Jn.D)({col:e,clustersCol:t,...n},_r.seqHelper)}static async compositionAnalysis(){const e=r.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(_r.seqHelper.getSeqHandler(e),!0))),n=async t=>{if(!(0,Zn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),i=t.find((e=>_r.seqHelper.getSeqHandler(e).isMsa())),o=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK((async()=>{const e=t.find((e=>e.name==o.value))??null;e&&await n(e)})).show()}else i=t[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}static importFasta(e){return new fe.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Pe.me)()[0];(0,Et.C)(e,_r.seqHelper)}static convertColumnAction(e){(0,Et.C)(e,_r.seqHelper)}static monomerCellRenderer(){return new oi}static async testDetectMacromolecule(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let i=0;const o=[];for(const s of n)try{const t=await r.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){o.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${e}`,s}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,Qe.cb)(10),!(0,Zn.V)(t,"Sequence space"))return e;const n=_r.seqHelper,i=(0,be.R)(t,n);i.name="splitToMonomers";const o=t.dataFrame;for(const e of i.columns)e.semType=Ve.uF.MONOMER,e.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=e=>{s.lastIndex=0;const t=e.match(s);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<i.columns.length;e++){const n=i.columns.byIndex(e);n.semType=Ve.uF.MONOMER,n.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const r=100;let s=0;for(;o.columns.byName(n.name)&&s<r;)n.name=l(n.name),s++;o.columns.add(n)}await r.data.detectSemanticTypes(o);for(let e=0;e<i.columns.length;e++){const t=i.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return o}(e,t)}static getHelmMonomers(e){return _r.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new At(_r.seqHelper)}static similaritySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new xt(_r.seqHelper)}static diversitySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Pe.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new pt.a7(t,_r.seqHelper)}static SubsequenceSearchTopMenu(e){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),r.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=_r.seqHelper;return yi(e,t,n,pe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=_r.seqHelper;return yi(e,t,n,pe.SIMILARITY,i)}static async manageMonomerLibraries(){Dn()}static async manageLibrariesView(){await Vn()}static async manageMonomersView(){const e=await En.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await Vn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e,t){(await(await dn.getInstance()).getFileManager()).getValidLibraryPaths().forEach((t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe((async()=>{const e=await En.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()}))}))}static saveAsFasta(){(0,Tt.TE)()}static bioSubstructureFilter(){return new _t._i(_r.seqHelper,_r.logger)}static bioSubstructureFilterTest(){return new _t._i(_r.seqHelper,_r.logger)}static async webLogoLargeApp(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new Qn(e,"webLogoLargeApp"),n=await _r.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new Qn(e,"webLogoAggApp"),n=await _r.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new mi(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await _r.files.readCsv("samples/HELM_empty_vals.csv"),n=new mi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=a.DataFrame.fromColumns((0,Ie.dW)());r.shell.addTableView(e)}static longSeqTableFasta(){const e=a.DataFrame.fromColumns([(0,Ie.Hx)(_r.seqHelper,ge.Hi.FASTA)]);r.shell.addTableView(e)}static longSeqTableHelm(){const e=a.DataFrame.fromColumns([(0,Ie.Hx)(_r.seqHelper,ge.Hi.HELM)]);r.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(ge.Hi).filter((e=>e!==ge.Hi.CUSTOM));t.group("Copy").items(i,(t=>{const i=e.column,o=e.rowIndex,s=n.getSeqHandler(i),a=t===ge.Hi.SEPARATOR?_r.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${t}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(e,t,_r.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await _r.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=r.shell.addTableView(e);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Pe.Kd)(t.grid,"sequence",500,30);const o=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await r.functions.eval("Bio:SeqSpaceDemo"),t=await r.dapi.projects.find(e.id);await t.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await _r.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=r.shell.addTableView(e);s.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Lr.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,me.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),mn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find((e=>e!==t.grid&&e.type===a.VIEWER.GRID));o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(t),_r.logger.error(e.message,void 0,n)}(e)}finally{s.setUpdateIndicator(t.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await _r.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const t=r.shell.addTableView(e),n=e.col("HELM");await Lr.toAtomicLevel(e,n,!0,!1),(0,Pe.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Pe.Kd)(t.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}static async sdfToJsonLib(e){const t=(0,ye.uX)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){if(!e.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[e]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await Lr.getMonomerLibHelper()).getMonomerLib(),l=_r.seqHelper,c=await(0,Ne.j)(),u=(await(0,fi.V)(i,n,t,!1,s,l,c))?.molCol?.get(0);return u??void 0}catch(e){const[t,n]=(0,we.AP)(e);throw _r.logger.error(t,void 0,n),e}}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[e]),i=a.DataFrame.fromColumns([n]);if(!await r.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await yi(i,n,t,pe.IDENTITY,_r.seqHelper)).get(0)}catch(e){const[t,n]=(0,we.AP)(e);throw _r.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const s=await r.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=a.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await r.functions.call("Bio:detectMacromolecule",{col:h})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Qe.cb)(0))}l>0?r.shell.warning(`detectMacromolecule failed ${l} / ${n}`):r.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await Lr.initBio(),_r.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=_r.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,_r.rdKitModule,i);return r.semType=a.SEMTYPE.MOLECULE,r}(0,t,n,_r.monomerLib)}}Mr([r.decorators.func({description:"Returns an instance of the monomer library helper",outputs:[{type:"object",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"getMonomerLibHelper",null),Mr([r.decorators.init({}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"initBio",null),Mr([r.decorators.func({tags:["tooltip"]}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",a.Widget)],Lr,"sequenceTooltip",null),Mr([r.decorators.func({outputs:[{type:"object",name:"monomerLib"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Object)],Lr,"getBioLib",null),Mr([r.decorators.func({outputs:[{type:"object",name:"result"}]}),Tr(0,r.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",Object)],Lr,"getSeqHandler",null),Mr([r.decorators.panel({name:"Bioinformatics | Get Region",description:"Creates a new column with sequences of the region between start and end"}),Tr(0,r.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",a.Widget)],Lr,"getRegionPanel",null),Mr([r.decorators.panel({name:"Bioinformatics | Manage Monomer Libraries",tags:["exclude-actions-panel"]}),Tr(0,r.decorators.param({name:"seqColumn",options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",Promise)],Lr,"libraryPanel",null),Mr([r.decorators.editor({}),Er("design:type",Function),Er("design:paramtypes",[a.FuncCall]),Er("design:returntype",void 0)],Lr,"GetRegionEditor",null),Mr([r.decorators.editor({}),Er("design:type",Function),Er("design:paramtypes",[a.FuncCall]),Er("design:returntype",void 0)],Lr,"SplitToMonomersEditor",null),Mr([r.decorators.editor({}),Er("design:type",Function),Er("design:paramtypes",[a.FuncCall]),Er("design:returntype",void 0)],Lr,"SequenceSpaceEditor",null),Mr([r.decorators.editor({}),Er("design:type",Function),Er("design:paramtypes",[a.FuncCall]),Er("design:returntype",void 0)],Lr,"SeqActivityCliffsEditor",null),Mr([r.decorators.func({name:"customSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=custom"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",a.GridCellRenderer)],Lr,"customSequenceCellRenderer",null),Mr([r.decorators.func({name:"fastaSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=fasta"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",ze)],Lr,"fastaSequenceCellRenderer",null),Mr([r.decorators.func({name:"separatorSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=separator"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",ze)],Lr,"separatorSequenceCellRenderer",null),Mr([r.decorators.panel({name:"Bioinformatics | Sequence Renderer"}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",a.Widget)],Lr,"macroMolColumnPropertyPanel",null),Mr([r.decorators.panel({name:"Composition analysis",tags:["bio","widgets"]}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.SemanticValue]),Er("design:returntype",a.Widget)],Lr,"compositionAnalysisWidget",null),Mr([r.decorators.func({name:"MacromoleculeDifferenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"MacromoleculeDifference",columnTags:"quality=MacromoleculeDifference"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Ke)],Lr,"macromoleculeDifferenceCellRenderer",null),Mr([r.decorators.func({outputs:[{type:"object",name:"result"}]}),Tr(0,r.decorators.param({options:{choices:["Local alignment","Global alignment"]}})),Tr(1,r.decorators.param({options:{choices:["AUTO","NUCLEOTIDES","BLOSUM45","BLOSUM50","BLOSUM62","BLOSUM80","BLOSUM90","PAM30","PAM70","PAM250","SCHNEIDER","TRANS"]}})),Er("design:type",Function),Er("design:paramtypes",[String,String,Number,String,String]),Er("design:returntype",void 0)],Lr,"sequenceAlignment",null),Mr([r.decorators.panel({name:"WebLogo",description:"WebLogo",tags:["viewer"],meta:{icon:"files/icons/weblogo-viewer.svg"},outputs:[{type:"viewer",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"webLogoViewer",null),Mr([r.decorators.panel({name:"VdRegions",description:"V-Domain regions viewer",tags:["viewer"],meta:{icon:"files/icons/vdregions-viewer.svg"},outputs:[{type:"viewer",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"vdRegionsViewer",null),Mr([r.decorators.func({name:"getRegion",description:"Gets a new column with sequences of the region between start and end"}),Tr(0,r.decorators.param({type:"column"})),Tr(1,r.decorators.param({type:"string",options:{optional:!0}})),Tr(2,r.decorators.param({type:"string",options:{optional:!0}})),Tr(3,r.decorators.param({type:"string",options:{optional:!0,description:"Name of the column to be created"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column,Object,Object,Object]),Er("design:returntype",a.Column)],Lr,"getRegion",null),Mr([r.decorators.func({name:"Get Region Top Menu",description:"Get sequences for a region specified from a Macromolecule","top-menu":"Bio | Calculate | Get Region...",editor:"Bio:GetRegionEditor"}),Tr(0,r.decorators.param({options:{description:"Input data table"}})),Tr(1,r.decorators.param({options:{semType:"Macromolecule",description:"Sequence column"}})),Tr(2,r.decorators.param({type:"string",options:{optional:!0,description:"Region start position name"}})),Tr(3,r.decorators.param({type:"string",options:{optional:!0,description:"Region end position name"}})),Tr(4,r.decorators.param({type:"string",options:{optional:!0,description:"Region column name"}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column,Object,Object,Object]),Er("design:returntype",Promise)],Lr,"getRegionTopMenu",null),Mr([r.decorators.func({name:"Sequence Activity Cliffs",description:"Detects pairs of molecules with similar structure and significant difference in any given property","top-menu":"Bio | Analyze | Activity Cliffs...",editor:"Bio:SeqActivityCliffsEditor",outputs:[]}),Tr(0,r.decorators.param({options:{description:"Input data table"}})),Tr(1,r.decorators.param({type:"string",options:{semType:"Macromolecule",description:"Input data table"}})),Tr(3,r.decorators.param({options:{initialValue:"80",description:"Similarity cutoff"}})),Tr(4,r.decorators.param({type:"string",options:{choices:["UMAP","t-SNE"]}})),Tr(5,r.decorators.param({type:"string",options:{choices:["Hamming","Levenshtein","Monomer chemical distance"]}})),Tr(6,r.decorators.param({type:"func"})),Tr(7,r.decorators.param({type:"object",options:{optional:!0}})),Tr(8,r.decorators.param({options:{optional:!0}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column,a.Column,Number,String,String,a.Func,Object,Boolean]),Er("design:returntype",Promise)],Lr,"activityCliffs",null),Mr([r.decorators.func({name:"Encode Sequences",tags:["dim-red-preprocessing-function"],meta:{supportedSemTypes:"Macromolecule",supportedTypes:"string",supportedDistanceFunctions:"Hamming,Levenshtein,Monomer chemical distance,Needlemann-Wunsch"},outputs:[{type:"object",name:"result"}]}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Tr(1,r.decorators.param({type:"string"})),Tr(2,r.decorators.param({options:{initialValue:"1",caption:"Gap open penalty",optional:!0}})),Tr(3,r.decorators.param({options:{initialValue:"0.6",caption:"Gap extension penalty",optional:!0}})),Tr(4,r.decorators.param({options:{caption:"Fingerprint type",initialValue:"Morgan",choices:["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"],optional:!0}})),Er("design:type",Function),Er("design:paramtypes",[a.Column,String,Number,Number,String]),Er("design:returntype",Promise)],Lr,"macromoleculePreprocessingFunction",null),Mr([r.decorators.func({name:"Helm Fingerprints",meta:{supportedSemTypes:"Macromolecule",supportedTypes:"string",supportedUnits:"helm",supportedDistanceFunctions:"Tanimoto,Asymmetric,Cosine,Sokal"},outputs:[{type:"object",name:"result"}]}),Tr(0,r.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Tr(1,r.decorators.param({type:"string"})),Er("design:type",Function),Er("design:paramtypes",[a.Column,String]),Er("design:returntype",Promise)],Lr,"helmPreprocessingFunction",null),Mr([r.decorators.func({name:"Sequence Space",description:"Creates 2D sequence space with projected sequences by pairwise distance","top-menu":"Bio | Analyze | Sequence Space...",editor:"Bio:SequenceSpaceEditor",outputs:[]}),Tr(1,r.decorators.param({options:{semType:"Macromolecule"}})),Tr(2,r.decorators.param({type:"string",options:{choices:["UMAP","t-SNE"]}})),Tr(3,r.decorators.param({type:"string",options:{choices:["Hamming","Levenshtein","Monomer chemical distance"]}})),Tr(4,r.decorators.param({options:{initialValue:"true"}})),Tr(5,r.decorators.param({type:"func",options:{optional:!0}})),Tr(6,r.decorators.param({type:"object",options:{optional:!0}})),Tr(7,r.decorators.param({options:{optional:!0,initialValue:"true"}})),Tr(8,r.decorators.param({options:{optional:!0}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column,String,String,Boolean,a.Func,Object,Boolean,Boolean]),Er("design:returntype",Promise)],Lr,"sequenceSpaceTopMenu",null),Mr([r.decorators.func({name:"To Atomic Level",description:"Converts sequences to molblocks","top-menu":"Bio | Transform | To Atomic Level..."}),Tr(0,r.decorators.param({options:{description:"Input data table"}})),Tr(1,r.decorators.param({options:{semType:"Macromolecule",caption:"Sequence"}})),Tr(2,r.decorators.param({options:{initialValue:"false",caption:"Non-linear",description:"Slower mode for cycling/branching HELM structures"}})),Tr(3,r.decorators.param({options:{initialValue:"false",caption:"Highlight monomers",description:"Highlight monomers' substructures of the molecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column,Boolean,Boolean]),Er("design:returntype",Promise)],Lr,"toAtomicLevel",null),Mr([r.decorators.func({name:"To Atomic Level...",meta:{action:"to atomic level"}}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",Promise)],Lr,"toAtomicLevelAction",null),Mr([r.decorators.panel({name:"Molecular Structure",tags:["bio","widgets"]}),Tr(0,r.decorators.param({name:"sequence",type:"semantic_value",options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.SemanticValue]),Er("design:returntype",Promise)],Lr,"toAtomicLevelPanel",null),Mr([r.decorators.panel({name:"Molecular 3D Structure",tags:["bio","widgets"]}),Tr(0,r.decorators.param({type:"semantic_value",options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.SemanticValue]),Er("design:returntype",Promise)],Lr,"sequence3dStructureWidget",null),Mr([r.decorators.panel({name:"MSA",description:"Performs multiple sequence alignment",tags:["bio"],"top-menu":"Bio | Analyze | MSA..."}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"multipleSequenceAlignmentDialog",null),Mr([r.decorators.func({name:"Multiple Sequence Alignment",description:"Multiple sequence alignment",tags:["bio"]}),Tr(0,r.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Tr(1,r.decorators.param({type:"column"})),Tr(2,r.decorators.param({type:"object",options:{optional:!0}})),Er("design:type",Function),Er("design:paramtypes",[Object,Object,Object]),Er("design:returntype",Promise)],Lr,"alignSequences",null),Mr([r.decorators.func({name:"Composition Analysis",description:"Visualizes sequence composition on a WebLogo plot","top-menu":"Bio | Analyze | Composition",meta:{icon:"files/icons/composition-analysis.svg"},outputs:[{name:"result",type:"viewer"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"compositionAnalysis",null),Mr([r.decorators.fileHandler({name:"importFasta",description:"Opens FASTA file",ext:"fasta, fna, ffn, faa, frn, fa, fst"}),Er("design:type",Function),Er("design:paramtypes",[String]),Er("design:returntype",Array)],Lr,"importFasta",null),Mr([r.decorators.fileHandler({name:"importBam",description:"Opens Bam file",ext:"bam, bai"}),Er("design:type",Function),Er("design:paramtypes",[String]),Er("design:returntype",Array)],Lr,"importBam",null),Mr([r.decorators.func({name:"convertDialog","top-menu":"Bio | Transform | Convert Notation..."}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"convertDialog",null),Mr([r.decorators.func({name:"Convert Notation...",meta:{action:"Convert Notation..."}}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",void 0)],Lr,"convertColumnAction",null),Mr([r.decorators.func({name:"monomerCellRenderer",tags:["cellRenderer"],meta:{cellType:"Monomer",columnTags:"quality=Monomer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",oi)],Lr,"monomerCellRenderer",null),Mr([r.decorators.func({name:"testDetectMacromolecule"}),Tr(0,r.decorators.param({options:{choices:["Demo:Files/","System:AppData/"]}})),Er("design:type",Function),Er("design:paramtypes",[String]),Er("design:returntype",Promise)],Lr,"testDetectMacromolecule",null),Mr([r.decorators.func({name:"Split to Monomers","top-menu":"Bio | Transform | Split to Monomers...",editor:"Bio:SplitToMonomersEditor"}),Tr(1,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column]),Er("design:returntype",Promise)],Lr,"splitToMonomersTopMenu",null),Mr([r.decorators.func({name:"Bio: getHelmMonomers",outputs:[{name:"result",type:"object"}]}),Tr(0,r.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",Array)],Lr,"getHelmMonomers",null),Mr([r.decorators.func({name:"Sequence Similarity Search",tags:["viewer"],meta:{icon:"files/icons/sequence-similarity-viewer.svg"},outputs:[{name:"result",type:"viewer"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",At)],Lr,"similaritySearchViewer",null),Mr([r.decorators.func({name:"similaritySearch",description:"Finds similar sequences","top-menu":"Bio | Search | Similarity Search",outputs:[{name:"result",type:"viewer"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"similaritySearchTopMenu",null),Mr([r.decorators.func({name:"Sequence Diversity Search",tags:["viewer"],meta:{icon:"files/icons/sequence-diversity-viewer.svg"},outputs:[{name:"result",type:"viewer"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",xt)],Lr,"diversitySearchViewer",null),Mr([r.decorators.func({name:"diversitySearch",description:"Finds the most diverse sequences","top-menu":"Bio | Search | Diversity Search",outputs:[{name:"result",type:"viewer"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"diversitySearchTopMenu",null),Mr([r.decorators.editor({name:"SearchSubsequenceEditor"}),Er("design:type",Function),Er("design:paramtypes",[a.FuncCall]),Er("design:returntype",void 0)],Lr,"searchSubsequenceEditor",null),Mr([r.decorators.func({name:"Subsequence Search","top-menu":"Bio | Search | Subsequence Search ...",editor:"Bio:SearchSubsequenceEditor"}),Er("design:type",Function),Er("design:paramtypes",[a.Column]),Er("design:returntype",void 0)],Lr,"SubsequenceSearchTopMenu",null),Mr([r.decorators.func({name:"Identity Scoring",description:"Adds a column with fraction of matching monomers","top-menu":"Bio | Calculate | Identity..."}),Tr(0,r.decorators.param({options:{description:"Table containing Macromolecule column"}})),Tr(1,r.decorators.param({options:{semType:"Macromolecule",description:"Sequences to score"}})),Tr(2,r.decorators.param({options:{description:"Sequence,matching column format"}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column,String]),Er("design:returntype",Promise)],Lr,"sequenceIdentityScoring",null),Mr([r.decorators.func({name:"Similarity Scoring",description:"Adds a column with similarity scores, calculated as sum of monomer fingerprint similarities","top-menu":"Bio | Calculate | Similarity..."}),Tr(0,r.decorators.param({options:{description:"Table containing Macromolecule column"}})),Tr(1,r.decorators.param({options:{semType:"Macromolecule",description:"Sequences to score"}})),Tr(2,r.decorators.param({options:{description:"Sequence,matching column format"}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column,String]),Er("design:returntype",Promise)],Lr,"sequenceSimilarityScoring",null),Mr([r.decorators.func({name:"Manage Monomer Libraries",description:"Manage HELM monomer libraries"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"manageMonomerLibraries",null),Mr([r.decorators.func({name:"Manage Monomer Libraries View","top-menu":"Bio | Manage | Monomer Libraries"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"manageLibrariesView",null),Mr([r.decorators.func({name:"manageMonomersView",description:"Edit and create monomers","top-menu":"Bio | Manage | Monomers"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"manageMonomersView",null),Mr([r.decorators.app({name:"Manage Monomer Libraries",browsePath:"Peptides",icon:"files/icons/monomers.png"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"manageMonomerLibrariesView",null),Mr([r.decorators.func({name:"Monomer Manager Tree Browser"}),Er("design:type",Function),Er("design:paramtypes",[a.TreeViewGroup,a.BrowsePanel]),Er("design:returntype",Promise)],Lr,"manageMonomerLibrariesViewTreeBrowser",null),Mr([r.decorators.fileExporter({description:"As FASTA..."}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"saveAsFasta",null),Mr([r.decorators.func({name:"Bio Substructure Filter",description:"Substructure filter for macromolecules",tags:["filter"],meta:{semType:"Macromolecule"},outputs:[{type:"filter",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",_t._i)],Lr,"bioSubstructureFilter",null),Mr([r.decorators.func({name:"Bio Substructure Filter Test",description:"Substructure filter for Helm package tests",outputs:[{name:"result",type:"object"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",_t._i)],Lr,"bioSubstructureFilterTest",null),Mr([r.decorators.func(),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"webLogoLargeApp",null),Mr([r.decorators.func(),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"webLogoAggApp",null),Mr([r.decorators.func(),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"getRegionApp",null),Mr([r.decorators.func(),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"getRegionHelmApp",null),Mr([r.decorators.func(),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"longSeqTableSeparator",null),Mr([r.decorators.func(),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"longSeqTableFasta",null),Mr([r.decorators.func(),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",void 0)],Lr,"longSeqTableHelm",null),Mr([r.decorators.func(),Tr(0,r.decorators.param({type:"object"})),Tr(1,r.decorators.param({type:"object"})),Er("design:type",Function),Er("design:paramtypes",[a.Cell,a.Menu]),Er("design:returntype",void 0)],Lr,"addCopyMenu",null),Mr([r.decorators.demo({description:"Sequence similarity tracking and evaluation dataset diversity",demoPath:"Bioinformatics | Similarity, Diversity",path:"/apps/Tutorials/Demo/Bioinformatics/Similarity,%20Diversity",demoSkip:"GROK-14320"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"demoBioSimilarityDiversity",null),Mr([r.decorators.demo({description:"Exploring sequence space of Macromolecules, comparison with hierarchical clustering results",demoPath:"Bioinformatics | Sequence Space",path:"/apps/Tutorials/Demo/Bioinformatics/Sequence%20Space",demoSkip:"GROK-14320"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"demoBioSequenceSpace",null),Mr([r.decorators.demo({description:"Activity Cliffs analysis on Macromolecules data",demoPath:"Bioinformatics | Activity Cliffs",path:"/apps/Tutorials/Demo/Bioinformatics/Activity%20Cliffs",demoSkip:"GROK-14320"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"demoBioActivityCliffs",null),Mr([r.decorators.demo({description:"Atomic level structure of Macromolecules",demoPath:"Bioinformatics | Atomic Level",path:"/apps/Tutorials/Demo/Bioinformatics/Atomic%20Level",demoSkip:"GROK-14320"}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"demoBioAtomicLevel",null),Mr([r.decorators.func({name:"SDF to JSON Library"}),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame]),Er("design:returntype",Promise)],Lr,"sdfToJsonLib",null),Mr([r.decorators.func({friendlyName:"seq2atomic",description:"Converts a `Macromolecule` sequence to its atomic level `Molecule` representation",outputs:[{name:"molfile",type:"string",options:{semType:"Molecule"}}]}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[String,Boolean]),Er("design:returntype",Promise)],Lr,"seq2atomic",null),Mr([r.decorators.func({name:"seqIdentity",friendlyName:"seqIdentity",description:"Gets identity to a reference sequence"}),Tr(0,r.decorators.param({options:{semType:"Macromolecule"}})),Tr(1,r.decorators.param({options:{semType:"Macromolecule"}})),Er("design:type",Function),Er("design:paramtypes",[String,String]),Er("design:returntype",Promise)],Lr,"seqIdentity",null),Mr([r.decorators.func(),Tr(2,r.decorators.param({options:{initialValue:"100"}})),Er("design:type",Function),Er("design:paramtypes",[a.FileInfo,String,Number]),Er("design:returntype",Promise)],Lr,"detectMacromoleculeProbe",null),Mr([r.decorators.func({outputs:[{type:"object",name:"result"}]}),Er("design:type",Function),Er("design:paramtypes",[]),Er("design:returntype",Promise)],Lr,"getSeqHelper",null),Mr([r.decorators.func(),Tr(1,r.decorators.param({type:"column"})),Tr(2,r.decorators.param({options:{initialValue:"true"}})),Er("design:type",Function),Er("design:paramtypes",[a.DataFrame,a.Column,Boolean]),Er("design:returntype",Promise)],Lr,"getMolFromHelm",null);class Nr{_palette;constructor(e){this._palette=e}get(e){return this._palette[e]}}function Pr(){return _r.logger.debug("Bio:test1() function"),{value:"value1"}}},4954:(e,t,n)=>{"use strict";n.d(t,{a7:()=>m,if:()=>f,BQ:()=>y,nI:()=>g});var i=n(4328),o=n(7389),r=n(6082),s=n(8070),a=n(2003),l=n(439);const c=31;async function u(e,t,n=!1,o){const s=t.getSeqHandler(e);let a;o??=new Map;const l=s.isHelm()?t.getSeqMonomers(e):Object.keys(s.stats.freq).filter((e=>""!==e));for(let e=0;e<l.length;e++)o.has(l[e])||o.set(l[e],`${o.size+1}`);if(s.isHelm())a=await i.functions.call("HELM:getMolFiles",{col:e}),a=function(e,t,n=!1){const i=new Array(e.length);for(let o=0;o<e.length;o++){let r=0,s=0,a="\n    Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";const l=e.get(o);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const u=parseInt(l.substring(r,r+3)),h=parseInt(l.substring(r+3,r+6));a+=`M  V30 COUNTS ${u} ${h} 0 0 0\n`,a+="M  V30 BEGIN ATOM\n";for(let e=0;e<u;e++){r=l.indexOf("\n",r)+1+c,s=l.indexOf(" ",r);const i=l.substring(r,s);a+=n?`M  V30 ${e+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M  V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(i)}\n`}a+="M  V30 END ATOM\n",a+="M  V30 BEGIN BOND\n";for(let e=0;e<h;e++){r=l.indexOf("\n",r)+1;const t=parseInt(l.substring(r,r+3).trim()),n=parseInt(l.substring(r+3,r+6).trim());a+=`M  V30 ${e+1} ${parseInt(l.substring(r+6,r+9).trim())} ${t} ${n}\n`}a+="M  V30 END BOND\n",a+="M  V30 END CTAB\n",a+="M  END",i[o]=a}return i}(a,o,n);else{a=new Array(e.length);for(let t=0;t<e.length;t++){const e=h(s.getSplitted(t),o,n);a[t]=e}}return r.Column.fromStrings("monomericMols",a)}function h(e,t,n=!1){let i="\n  Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";i+=`M  V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,i+="M  V30 BEGIN ATOM\n";for(let o=0;o<e.length;o++){const r=e.getCanonical(o);r!==l._S&&(i+=n?`M  V30 ${o+1} R${t.get(r)} 0.000 0.000 0 0\n`:`M  V30 ${o+1} At 0.000 0.000 0 0 MASS=${t.get(r)}\n`)}i+="M  V30 END ATOM\n",i+="M  V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)i+=`M  V30 ${t+1} 1 ${t+1} ${t+2}\n`;return i+="M  V30 END BOND\n",i+="M  V30 END CTAB\n",i+="M  END",i}var d=n(4870);const p="substr_helm";class m{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,d.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(p,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===a.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,d.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const t=r.DataFrame.create(1);t.columns.addNewString(p).init((e=>"")),t.col(p).semType=this.col.semType,t.col(p).meta.units=a.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,n=this.units===a.Hi.HELM?t.get(p,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===a.Hi.HELM?await f(n,this.col,this.seqHelper):g(n,this.col),this.col.dataFrame.filter.and(e)})).show()}}function g(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,o=e.charAt(e.length-1)===t,r=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(e,n):e,o=r.BitSet.create(t.length);for(let n=0;n<t.length;n++){const r=t.get(n);(r.match(i)||r===e)&&o.set(n,!0,!1)}return o}async function f(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await y(t,n,!0);const o=r.Column.string("helm",1).init((t=>e));o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=a.Hi.HELM;const s=await u(o,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function y(e,t,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,s.cb)(10);const i=new Map,o=await u(e,t,n,i);e.temp["monomeric-mols"]=o,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(8926);function s(e,t,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,u]=a(e,t,l,n,o);return s&&!c&&i.shell.warning(u),c}function a(e,t,n,r=[],s=[]){let a=!0,l="";if(e.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),o=i.notation;if(r.length>0&&!r.some((e=>o.toUpperCase()==e.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==r.length?"any notation":`notation${r.length>1?"s":""} ${r.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const e=i.alphabet;s.length>0&&!s.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>u,J:()=>a,b9:()=>c,uF:()=>r});var i,o,r,s,a,l=n(8152);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(o||(o={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(e){e.CELL_CHANGING="isCellChanging"}(s||(s={})),function(e){e.SEPARATOR="."}(a||(a={}));const c="3.3.1",u={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(e,t,n)=>{"use strict";n.d(t,{C:()=>h});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,u=[];function h(e,t){let n=e??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=t.getSeqHandler(n),h=s.notation;const d=o.divText("Current notation: "+h,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=o.input.column("Column",{table:r.shell.t,value:n,filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:e=>(n=e,s=t.getSeqHandler(n),h=s.notation,h===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+h,f=p.filter((e=>e!==h)),v=o.input.choice("Convert to",{value:f[0],items:f,onValueChanged:b}),b(),c?.clear(),void c?.add(o.div([d,m.root,v.root,y.root])))}),g=["-",".","/"];let f=p.filter((e=>e!==h));const y=o.input.choice("Separator",{value:g[0],items:g}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=o.input.choice("Convert to",{value:f[0],items:f,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=o.dialog("Convert Sequence Notation").add(o.div([d,m.root,v.root,y.root])).onOK((async()=>{const e=v.value,i=e===l.Hi.SEPARATOR?y.value:void 0;await async function(e,t,n,i){const o=t.getSeqHandler(e).convert(n,i);e.dataFrame.columns.add(o);const s=await r.functions.call("Bio:detectMacromolecule",{col:o});return s&&(o.semType=s),await r.data.detectSemanticTypes(e.dataFrame),o}(n,t,e,i)})).show({x:350,y:100}),u.push(c.onClose.subscribe((e=>{u.forEach((e=>{e.unsubscribe()})),u=[],c=null}))))}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>r,pk:()=>o,xe:()=>i});const i="|",o="$",r="H"},2582:(e,t,n)=>{"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.xe).filter((e=>e));t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],i=t.split(",");i[2].split("-").forEach(((e,t)=>{const o=i[t],r=e.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})})),e.push(n)})),e}}var r=n(8438);class s{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach((e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter((e=>!!e)).map((e=>(0,r.D)(e)));n.push(...t),t.forEach(((e,t)=>i.push(t%3==1?"Branch":"Backbone")))}else n.push((0,r.D)(e)),i.push("Backbone")})),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(i.pk),n=t[0].split(i.xe);this.simplePolymers=n.map((e=>new s(e))),this.connectionList=new o(t[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map((e=>e.monomers.length)).reduce(((e,t)=>e+t),0),t=Array.from({length:e},(()=>[]));return this.bondData.forEach((e=>{e.forEach((e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)}))})),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===i))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)})),t.push(i)})),t}}},8604:(e,t,n)=>{"use strict";n.d(t,{Es:()=>o,G3:()=>s,gt:()=>r,so:()=>i});const i="System:AppData/Bio/monomer-libraries/",o="System:AppData/Bio/monomer-sets/",r="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json",s={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>T});var i=n(4328),o=n(6082),r=n(7389),s=n(8070),a=n(2003),l=n(608),c=n(8152),u=n(966),h=n(4139),d=n(5072),p=n.n(d),m=n(7825),g=n.n(m),f=n(7659),y=n.n(f),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),S=n(1113),A=n.n(S),x=n(6369),M={};M.styleTagTransform=A(),M.setAttributes=v(),M.insert=y().bind(null,"head"),M.domAPI=g(),M.insertStyleElement=C(),p()(x.A,M),x.A&&x.A.locals&&x.A.locals;var E=n(8926);async function T(e,t){return new Promise((async(n,a)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=h.HX.pepsea.method,e.pepsea.gapOpen??=h.HX.pepsea.gapOpen,e.pepsea.gapExtend??=h.HX.pepsea.gapExtend;const u=e.col?.dataFrame??i.shell.t;if(!u){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const d=e.col??u.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(null==d){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const p=r.input.choice("Method",{value:e.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=r.p(`Kalign version: ${h.b9}`,"kalign-version"),f=r.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=r.input.bool("Selected Rows Only",{value:!1}),v=r.inputs([f,y,m]),w=r.button("Alignment parameters",(()=>{v.hidden=!v.hidden,[f,y,m].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");w.classList.add("msa-params-button"),v.hidden=!0,w.prepend(r.icons.settings((()=>null)));const C=[p.root.style],S=[m.root.style,g.style];let A,x=d;const M=r.input.column("Sequence",{table:u,value:d,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return L.disabled=!0,await(0,s.cb)(0),void(M.value=x);x=e,L.disabled=!1,A=await I(M.value,u,t,C,S,p,E,f,y,m,b)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});M.setTooltip("Sequences column to use for alignment");const E=r.input.column("Clusters",{table:u,value:e.clustersCol});E.nullable=!0;const T=r.dialog("MSA").add(M).add(E).add(p).add(v).add(w).add(b).add(g).onOK((async()=>{await _(M,u,A,n,a)})),L=T.getButton("OK");if(M.fireChanged(),e.col)return A=await I(e.col,u,t,C,S,p,E,f,y,m,b),void await _(M,u,A,n,a);T.show()}))}async function _(e,t,n,r,s){let a=null;const l=o.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return s("PepSeA container has not started");t.columns.add(a),await i.data.detectSemanticTypes(t),r(a)}catch(e){s(e)}finally{l.close()}}async function I(e,t,n,r,s,d,p,m,g,f,y){try{if(e.semType!==o.SEMTYPE.MACROMOLECULE)return;const i=t.columns.getUnusedName(`msa(${e.name})`);if((0,u.l)(e,e.name,n,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT])[0]){L(r,s,"kalign"),m.value=null,g.value=null,f.value=null;const o=n.getSeqHandler(e),c=o.isFasta()?e:o.convert(a.Hi.FASTA);return async()=>await(0,l.eE)(t,c,!1,i,p.value,void 0,void 0,void 0,y.value)}if((0,u.l)(e,e.name,n,[a.Hi.HELM],[])[0])return L(r,s,"pepsea"),m.value??=h.HX.pepsea.gapOpen,g.value??=h.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,e,i,d.value,m.value,g.value,p.value,void 0,y.value);if((0,u.l)(e,e.name,n,[a.Hi.SEPARATOR],[a.YI.UN])[0]){const o=n.getSeqHandler(e).convert(a.Hi.HELM);return L(r,s,"pepsea"),m.value??=h.HX.pepsea.gapOpen,g.value??=h.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,o,i,d.value,m.value,g.value,p.value,void 0,y.value)}return m.value=null,g.value=null,f.value=null,void L(r,s,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),E._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}},608:(e,t,n)=>{"use strict";n.d(t,{Ap:()=>H,aZ:()=>D,eE:()=>G});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),h=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),p=e=>"object"==typeof e&&null!==e||"function"==typeof e,m=new Map([["proxy",{canHandle:e=>p(e)&&e[c],serialize(e){const{port1:t,port2:n}=new MessageChannel;return g(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>p(e)&&d in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function g(e,t=self){t.addEventListener("message",(function n(i){if(!i||!i.data)return;const{id:o,type:r,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const t=s.slice(0,-1).reduce(((e,t)=>e[t]),e),n=s.reduce(((e,t)=>e[t]),e);switch(r){case"GET":l=n;break;case"SET":t[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(t,a);break;case"CONSTRUCT":l=function(e){return Object.assign(e,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;g(e,n),l=function(e,t){return S.set(e,t),e}(t,[t])}break;case"RELEASE":l=void 0;break;default:return}}catch(e){l={value:e,[d]:0}}Promise.resolve(l).catch((e=>({value:e,[d]:0}))).then((e=>{const[i,s]=A(e);t.postMessage(Object.assign(Object.assign({},i),{id:o}),s),"RELEASE"===r&&(t.removeEventListener("message",n),f(t))}))})),t.start&&t.start()}function f(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return v(e,[],t)}function b(e){if(e)throw new Error("Proxy has been released and is not useable")}function v(e,t=[],n=function(){}){let i=!1;const o=new Proxy(n,{get(n,r){if(b(i),r===h)return()=>M(e,{type:"RELEASE",path:t.map((e=>e.toString()))}).then((()=>{f(e),i=!0}));if("then"===r){if(0===t.length)return{then:()=>o};const n=M(e,{type:"GET",path:t.map((e=>e.toString()))}).then(x);return n.then.bind(n)}return v(e,[...t,r])},set(n,o,r){b(i);const[s,a]=A(r);return M(e,{type:"SET",path:[...t,o].map((e=>e.toString())),value:s},a).then(x)},apply(n,o,r){b(i);const s=t[t.length-1];if(s===u)return M(e,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(e,t.slice(0,-1));const[a,l]=C(r);return M(e,{type:"APPLY",path:t.map((e=>e.toString())),argumentList:a},l).then(x)},construct(n,o){b(i);const[r,s]=C(o);return M(e,{type:"CONSTRUCT",path:t.map((e=>e.toString())),argumentList:r},s).then(x)}});return o}function w(e){return Array.prototype.concat.apply([],e)}function C(e){const t=e.map(A);return[t.map((e=>e[0])),w(t.map((e=>e[1])))]}const S=new WeakMap;function A(e){for(const[t,n]of m)if(n.canHandle(e)){const[i,o]=n.serialize(e);return[{type:"HANDLER",name:t,value:i},o]}return[{type:"RAW",value:e},S.get(e)||[]]}function x(e){switch(e.type){case"HANDLER":return m.get(e.name).deserialize(e.value);case"RAW":return e.value}}function M(e,t,n){return new Promise((i=>{const o=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");e.addEventListener("message",(function t(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",t),i(n.data))})),e.start&&e.start(),e.postMessage(Object.assign({id:o},t),n)}))}const E="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{t.config.printStream?postMessage({type:"biowasm",value:{stdout:i}}):e.stdout+=i+`
`},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";t.config.printStream?postMessage({type:"biowasm",value:{[s]:i}}):e[s]+=i+`
`}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",T=typeof window<"u"&&window.Blob&&new Blob([atob(E)],{type:"text/javascript;charset=utf-8"});function _(){const e=T&&(window.URL||window.webkitURL).createObjectURL(T);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+E)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const I={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class L{constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},I,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new _;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class P{static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}P.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class R{constructor(e="categorial"){this.aa2num=P.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const i=["NH2","COOH"];if(e.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${i[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(i[1])){const t=i[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${i[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return R._dropDefises(R._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let i=0;i<t;++i){const t=e[i];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[i]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const i=e[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${e}'`),t+=this.num2aa[i]}return t}}var $=n(4139);const O="input.fa",k="result.fasta";class H extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function F(e){return e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function G(e,t,n=!1,i="",r=null,s,c,u,h){let d=t.toList();n&&(d=d.map((e=>R.clean(e).replace(/\-/g,""))));const p=t.length;r??=o.Column.string("Clusters",p).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const m=r.categories,g=r.getRawData(),f=new Array(m.length),y=new Array(m.length);if(h){const t=e.selection;if(0===t.length)throw new Error("No selected rows in the table.");for(let e=-1;-1!==(e=t.findNext(e,!0));){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}}else for(let e=0;e<p;++e){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}D(y,m);const b=await new L(["base/1.0.0",{tool:"kalign",version:$.b9,reinit:!0}]),v=o.Column.string(i,p);for(let e=0;e<m.length;++e){const t=f[e];if(!t||0===t.length)continue;const n=F(t);await b.fs.writeFile(O,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==u?` --tgpe ${u}`:""}`,o=await b.exec(`kalign ${O} -f fasta -o ${k}${i}`);console.warn(o);const r=await b.cat(k);if(!r){const e=B(o,1);throw new Error(e)}const l=new a.m(r).sequencesArray,h=y[e];for(let e=0;e<l.length;++e)v.set(h[e],l[e])}const w=t.meta.units,C=t.getTag(l.gp.alphabet);return v.meta.units=w,v.setTag(l.gp.aligned,"SEQ.MSA"),v.setTag(l.gp.alphabet,C),v.semType=o.SEMTYPE.MACROMOLECULE,v}function B(e,t){const n=[],i=/^.+ERROR : (.+)$/gm;let o;for(;null!=(o=i.exec(e))&&(void 0===t||n.length<t);)n.push(o[1]);return n.join("\n")}function D(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map((e=>{let o=t[e];return o.length>25&&(o=o.slice(0,25)+"..."),i.divText(`"${o}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new H(e)}}},8152:(e,t,n)=>{"use strict";n.d(t,{GD:()=>d,ZY:()=>u});var i=n(4328),o=n(6082),r=n(2003),s=n(608),a=n(4139),l=n(8926);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n,i="ginsi",l=1.53,u=0,d=null,m,g=!1){const f=await c.getDockerContainer(),y=t.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,v=d.getRawData(),w=new Array(b.length),C=new Array(b.length);if(g){const n=e.selection;for(let e=-1;-1!==(e=n.findNext(e,!0));){const n=v[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((w[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}}else for(let e=0;e<y;++e){const n=v[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((w[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}(0,s.aZ)(C,b);const S=new Array(y).fill(null);for(const e of w){if(!e||0===e.length)continue;const t=(await p(f.id,e,i,l,u,m)).Alignment;for(const e of t)S[parseInt(e.ID)]=Object.entries(e).filter((e=>!h.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(a.J.SEPARATOR)}const A=o.Column.fromStrings(n,S);return A.meta.units=r.Hi.SEPARATOR,A.setTag(r.gp.separator,a.J.SEPARATOR),A.setTag(r.gp.aligned,"SEQ.MSA"),A.setTag(r.gp.alphabet,r.YI.UN),A.setTag(r.gp.alphabetIsMultichar,"true"),A.semType=o.SEMTYPE.MACROMOLECULE,A}async function p(e,t,n,o,r,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-u} ms`);const p="application/json"===h.headers.get("content-type");if(!h.ok&&p){const e=await h.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const n=e["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(h.statusText)}if(!h.ok&&!p){const e=await h.text();throw new Error(`Error: ${e}`)}if(!p){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const m=await h.json();if("pepsea-stderr"in m){const e=m["pepsea-stderr"];s?.warning(e)}return m}},3890:(e,t,n)=>{"use strict";n.d(t,{TE:()=>u});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(8926);const c=60;function u(){const e=r.shell.tv.grid,t=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>!!e.column&&e.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),n=t.find((e=>-1!==e.name.toLowerCase().indexOf("id"))),s=n?[n.name]:[],u=o.input.multiChoice("Seq id columns",{value:s,items:t.map((e=>e.name))}),d=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>{const t=e.column;return!(!t||t.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(t).isFasta()})).toArray(),p=d.length>0?d[0].name:[],m=o.input.choice("Seq column",{value:p,items:d.map((e=>e.name))}),g=o.input.int("FASTA line width",{value:c});o.dialog({title:"Save as FASTA"}).add(o.inputs([u,m,g])).onOK((()=>{const t=u.value?u.value.map((t=>e.columns.byName(t).column)):[],n=m.value?e.columns.byName(m.value).column:null,i=g.value??c;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=function(e,t,n=c,i="\n"){const o=[];for(let r=0;r<t.length;r++){const s=e.map((e=>e.get(r).toString())).join("|"),a=h(t.getSplitted(r),n);o.push(`>${s}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}(t,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()})).show()}function h(e,t=c){let n=0;const i=e.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(e.length-n,t)).map((t=>e.getOriginal(t))).toArray(),r=i.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");o.push(r),n+=i.length}return o}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function u(e,t,n,u,h,d,p){let m;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let o,a;i.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,e.columns.add(o,!1));try{m=await n.helmToAtomicLevel(o,!0,!0,h)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,o.C4)(e,t,h,d,p)}if(m.molCol){const o=(0,c.qj)(e,t.name);m.molCol.name=o,e.columns.add(m.molCol,!0),await(0,a.Qc)(t,m.molCol,h,d,p,n),m.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await i.data.detectSemanticTypes(e)}return m}},4870:(e,t,n)=>{"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const e=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null===e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function s(e,t){e.innerHTML="",e.append(t)}function a(e,t,n,i,o){const r=()=>{const o=e.col(t);o&&(o.width=n),i&&(e.props.rowHeight=i)};if(o)return void r();const s=e.onAfterDrawOverlay.subscribe((()=>{s.unsubscribe(),setTimeout((()=>{r()}))}))}},250:(e,t,n)=>{"use strict";n.d(t,{n5:()=>C,oP:()=>_});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(2003),d=n(4326);function p(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?p(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var m=n(8070),g=n(7602),f=n(439),y=n(6882);var b=n(8926);function v(e,t,n){return Math.abs(e-t)<=n}var w,C,S=n(6307);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class A{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class x{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const p=Object.entries(this._freqs).sort(((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1));for(const[n,i]of p){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){const c=(0,h.zS)(a,s),u=l.bounds,d=u.left;let p=y.S$;r&&(p=r.getMonomerTextColor(o,a)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const m=e.measureText(c);e.setTransform(u.width/m.width,0,0,u.height/i,d,u.top),e.fillText(c,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,S.F)(Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const T=new class{render=20};class _ extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter((t=>!e.includes(t)));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then((e=>{this.monomerLib=e.getMonomerLib(),this.render(E.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(E.Render,"monomerLib changed")})))})),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,T.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return void 0===r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount)).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(h.z1).map((e=>e.trim())):[...Array(o).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(h.z1).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new x(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],h=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(E.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(E.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(7602),d=n(4954),p=n(4574),m=n(1757),g=n.n(m),f=n(9124),y=n(9192),b=n(4870),v=n(8926);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class S{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class A extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new M:this.notation===c.Hi.SEPARATOR?new E(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),r.events.fireCustomEvent(C,new S(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class M extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new p.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class E extends p.O{emptyProps=new A("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new A(e,this.props.separator,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new A(this.props.substructure,t,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new A("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},9713:e=>{"use strict";e.exports=rxjs.operators},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use strict";e.exports=wu},8343:(e,t,n)=>{"use strict";const{normalizeIPv6:i,normalizeIPv4:o,removeDotSegments:r,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(e,t,n,i){const o={};return i||(e=p(u(e,n),n),t=p(u(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(o.scheme=t.scheme,o.userinfo=t.userinfo,o.host=t.host,o.port=t.port,o.path=r(t.path||""),o.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(o.userinfo=t.userinfo,o.host=t.host,o.port=t.port,o.path=r(t.path||""),o.query=t.query):(t.path?("/"===t.path.charAt(0)?o.path=r(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?o.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:o.path=t.path:o.path="/"+t.path,o.path=r(o.path)),o.query=t.query):(o.path=e.path,void 0!==t.query?o.query=t.query:o.query=e.query),o.userinfo=e.userinfo,o.host=e.host,o.port=e.port),o.scheme=e.scheme),o.fragment=t.fragment,o}function u(e,t){const n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=r(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),o.push(e)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const h=Array.from({length:127},((e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(e,t){const n=Object.assign({},t),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const c=e.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const e=o(r.host);if(!1===e.isIPV4){const t=i(e.host);r.host=t.host.toLowerCase(),a=t.isIPV6}else r.host=e.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 0===r.fragment?r.reference="absolute":r.reference="uri":r.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==r.reference&&(r.error=r.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||r.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&r.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(r.host))try{r.host=URL.domainToASCII(r.host.toLowerCase())}catch(e){r.error=r.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(s&&void 0!==r.scheme&&(r.scheme=unescape(r.scheme)),s&&void 0!==r.host&&(r.host=unescape(r.host)),r.path&&(r.path=escape(unescape(r.path))),r.fragment&&(r.fragment=encodeURI(decodeURIComponent(r.fragment)))),e&&e.parse&&e.parse(r,n)}else r.error=r.error||"URI can not be parsed.";return r}const m={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(p(e,t),t):"object"==typeof e&&(e=p(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(p(e,i),p(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:p};e.exports=m,e.exports.default=m,e.exports.fastUri=m},343:e=>{"use strict";const t=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function o(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function r(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const s={scheme:"http",domainHost:!0,parse:o,serialize:r},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=i(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(i(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:o,serialize:r},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const i=e.path.match(n);if(i){const n=t.scheme||e.scheme||"urn";e.nid=i[1].toLowerCase(),e.nss=i[2];const o=`${n}:${t.nid||e.nid}`,r=l[o];e.path=void 0,r&&(e=r.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",i=e.nid.toLowerCase(),o=`${n}:${t.nid||i}`,r=l[o];r&&(e=r.serialize(e,t));const s=e,a=e.nss;return s.path=`${i||t.nid}:${a}`,t.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const i=e;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&t.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=l},4914:e=>{"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(e,t,n)=>{"use strict";const{HEX:i}=n(4914),o=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function r(e){if(c(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(o)||[],[n]=t;return n?{host:l(n,"."),isIPV4:!0}:{host:e,isIPV4:!1}}function s(e,t=!1){let n="",o=!0;for(const t of e){if(void 0===i[t])return;"0"!==t&&!0===o&&(o=!1),o||(n+=t)}return t&&0===n.length&&(n="0"),n}function a(e){if(c(e,":")<2)return{host:e,isIPV6:!1};const t=function(e){let t=0;const n={error:!1,address:"",zone:""},i=[],o=[];let r=!1,a=!1,l=!1;function c(){if(o.length){if(!1===r){const e=s(o);if(void 0===e)return n.error=!0,!1;i.push(e)}o.length=0}return!0}for(let s=0;s<e.length;s++){const u=e[s];if("["!==u&&"]"!==u)if(":"!==u)if("%"===u){if(!c())break;r=!0}else o.push(u);else{if(!0===a&&(l=!0),!c())break;if(t++,i.push(":"),t>7){n.error=!0;break}s-1>=0&&":"===e[s-1]&&(a=!0)}}return o.length&&(r?n.zone=o.join(""):l?i.push(o.join("")):i.push(s(o))),n.address=i.join(""),n}(e);if(t.error)return{host:e,isIPV6:!1};{let e=t.address,n=t.address;return t.zone&&(e+="%"+t.zone,n+="%25"+t.zone),{host:e,escapedHost:n,isIPV6:!0}}}function l(e,t){let n="",i=!0;const o=e.length;for(let r=0;r<o;r++){const s=e[r];"0"===s&&i?(r+1<=o&&e[r+1]===t||r+1===o)&&(n+=s,i=!1):(i=s===t,n+=s)}return n}function c(e,t){let n=0;for(let i=0;i<e.length;i++)e[i]===t&&n++;return n}const u=/^\.\.?\//u,h=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,p=/^\/?(?:.|\n)*?(?=\/|$)/u;e.exports={recomposeAuthority:function(e){const t=[];if(void 0!==e.userinfo&&(t.push(e.userinfo),t.push("@")),void 0!==e.host){let n=unescape(e.host);const i=r(n);if(i.isIPV4)n=i.host;else{const t=a(i.host);n=!0===t.isIPV6?`[${t.escapedHost}]`:e.host}t.push(n)}return"number"!=typeof e.port&&"string"!=typeof e.port||(t.push(":"),t.push(String(e.port))),t.length?t.join(""):void 0},normalizeComponentEncoding:function(e,t){const n=!0!==t?escape:unescape;return void 0!==e.scheme&&(e.scheme=n(e.scheme)),void 0!==e.userinfo&&(e.userinfo=n(e.userinfo)),void 0!==e.host&&(e.host=n(e.host)),void 0!==e.path&&(e.path=n(e.path)),void 0!==e.query&&(e.query=n(e.query)),void 0!==e.fragment&&(e.fragment=n(e.fragment)),e},removeDotSegments:function(e){const t=[];for(;e.length;)if(e.match(u))e=e.replace(u,"");else if(e.match(h))e=e.replace(h,"/");else if(e.match(d))e=e.replace(d,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(p);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];e=e.slice(i.length),t.push(i)}}return t.join("")},normalizeIPv4:r,normalizeIPv6:a,stringArrayToHexStripped:s}},3837:e=>{"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:e=>{"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},t={};function n(i){var o=t[i];if(void 0!==o)return o.exports;var r=t[i]={id:i,loaded:!1,exports:{}};return e[i].call(r.exports,r,r.exports,n),r.loaded=!0,r.exports}n.m=e,n.amdO={},n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var i in t)n.o(t,i)&&!n.o(e,i)&&Object.defineProperty(e,i,{enumerable:!0,get:t[i]})},n.u=e=>e+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),n.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;n.g.importScripts&&(e=n.g.location+"");var t=n.g.document;if(!e&&t&&(t.currentScript&&"SCRIPT"===t.currentScript.tagName.toUpperCase()&&(e=t.currentScript.src),!e)){var i=t.getElementsByTagName("script");if(i.length)for(var o=i.length-1;o>-1&&(!e||!/^http(s?):/.test(e));)e=i[o--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=e})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var i=n(8926);bio=i})();
 //# sourceMappingURL=package.js.map