@bgicli/bgicli 2.1.1 → 2.2.1

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (1267) hide show
  1. package/README.md +152 -74
  2. package/data/skills/aav-vector-design-agent/SKILL.md +198 -0
  3. package/data/skills/adaptyv/SKILL.md +112 -0
  4. package/data/skills/adhd-daily-planner/SKILL.md +271 -0
  5. package/data/skills/aeon/SKILL.md +372 -0
  6. package/data/skills/agent-browser/SKILL.md +159 -0
  7. package/data/skills/agentd-drug-discovery/SKILL.md +52 -0
  8. package/data/skills/ai-analyzer/SKILL.md +218 -0
  9. package/data/skills/alphafold/SKILL.md +183 -0
  10. package/data/skills/alphafold-database/SKILL.md +500 -0
  11. package/data/skills/anndata/SKILL.md +394 -0
  12. package/data/skills/antibody-design-agent/SKILL.md +64 -0
  13. package/data/skills/arboreto/SKILL.md +237 -0
  14. package/data/skills/armored-cart-design-agent/SKILL.md +225 -0
  15. package/data/skills/arxiv-search/SKILL.md +224 -0
  16. package/data/skills/autonomous-oncology-agent/SKILL.md +77 -0
  17. package/data/skills/bayesian-optimizer/SKILL.md +60 -0
  18. package/data/skills/benchling-integration/SKILL.md +473 -0
  19. package/data/skills/bgpt-paper-search/SKILL.md +81 -0
  20. package/data/skills/bindcraft/SKILL.md +198 -0
  21. package/data/skills/binder-design/SKILL.md +182 -0
  22. package/data/skills/binding-characterization/SKILL.md +234 -0
  23. package/data/skills/bindingdb-database/SKILL.md +332 -0
  24. package/data/skills/bio-admet-prediction/SKILL.md +224 -0
  25. package/data/skills/bio-alignment-files-bam-statistics/SKILL.md +340 -0
  26. package/data/skills/bio-alignment-filtering/SKILL.md +322 -0
  27. package/data/skills/bio-alignment-indexing/SKILL.md +249 -0
  28. package/data/skills/bio-alignment-io/SKILL.md +301 -0
  29. package/data/skills/bio-alignment-msa-parsing/SKILL.md +366 -0
  30. package/data/skills/bio-alignment-msa-statistics/SKILL.md +375 -0
  31. package/data/skills/bio-alignment-pairwise/SKILL.md +277 -0
  32. package/data/skills/bio-alignment-sorting/SKILL.md +296 -0
  33. package/data/skills/bio-alignment-validation/SKILL.md +374 -0
  34. package/data/skills/bio-atac-seq-atac-peak-calling/SKILL.md +221 -0
  35. package/data/skills/bio-atac-seq-atac-qc/SKILL.md +292 -0
  36. package/data/skills/bio-atac-seq-differential-accessibility/SKILL.md +268 -0
  37. package/data/skills/bio-atac-seq-footprinting/SKILL.md +256 -0
  38. package/data/skills/bio-atac-seq-motif-deviation/SKILL.md +319 -0
  39. package/data/skills/bio-atac-seq-nucleosome-positioning/SKILL.md +321 -0
  40. package/data/skills/bio-basecalling/SKILL.md +368 -0
  41. package/data/skills/bio-batch-downloads/SKILL.md +384 -0
  42. package/data/skills/bio-batch-processing/SKILL.md +303 -0
  43. package/data/skills/bio-bedgraph-handling/SKILL.md +336 -0
  44. package/data/skills/bio-blast-searches/SKILL.md +354 -0
  45. package/data/skills/bio-causal-genomics-colocalization-analysis/SKILL.md +264 -0
  46. package/data/skills/bio-causal-genomics-fine-mapping/SKILL.md +267 -0
  47. package/data/skills/bio-causal-genomics-mediation-analysis/SKILL.md +264 -0
  48. package/data/skills/bio-causal-genomics-mendelian-randomization/SKILL.md +221 -0
  49. package/data/skills/bio-causal-genomics-pleiotropy-detection/SKILL.md +292 -0
  50. package/data/skills/bio-cfdna-preprocessing/SKILL.md +200 -0
  51. package/data/skills/bio-chipseq-differential-binding/SKILL.md +262 -0
  52. package/data/skills/bio-chipseq-motif-analysis/SKILL.md +387 -0
  53. package/data/skills/bio-chipseq-peak-annotation/SKILL.md +239 -0
  54. package/data/skills/bio-chipseq-peak-calling/SKILL.md +277 -0
  55. package/data/skills/bio-chipseq-qc/SKILL.md +391 -0
  56. package/data/skills/bio-chipseq-super-enhancers/SKILL.md +288 -0
  57. package/data/skills/bio-chipseq-visualization/SKILL.md +289 -0
  58. package/data/skills/bio-clinical-databases-clinvar-lookup/SKILL.md +188 -0
  59. package/data/skills/bio-clinical-databases-dbsnp-queries/SKILL.md +171 -0
  60. package/data/skills/bio-clinical-databases-gnomad-frequencies/SKILL.md +205 -0
  61. package/data/skills/bio-clinical-databases-hla-typing/SKILL.md +248 -0
  62. package/data/skills/bio-clinical-databases-myvariant-queries/SKILL.md +174 -0
  63. package/data/skills/bio-clinical-databases-pharmacogenomics/SKILL.md +232 -0
  64. package/data/skills/bio-clinical-databases-polygenic-risk/SKILL.md +276 -0
  65. package/data/skills/bio-clinical-databases-somatic-signatures/SKILL.md +261 -0
  66. package/data/skills/bio-clinical-databases-tumor-mutational-burden/SKILL.md +301 -0
  67. package/data/skills/bio-clinical-databases-variant-prioritization/SKILL.md +225 -0
  68. package/data/skills/bio-clip-seq-binding-site-annotation/SKILL.md +66 -0
  69. package/data/skills/bio-clip-seq-clip-alignment/SKILL.md +70 -0
  70. package/data/skills/bio-clip-seq-clip-motif-analysis/SKILL.md +62 -0
  71. package/data/skills/bio-clip-seq-clip-peak-calling/SKILL.md +282 -0
  72. package/data/skills/bio-clip-seq-clip-preprocessing/SKILL.md +142 -0
  73. package/data/skills/bio-codon-usage/SKILL.md +353 -0
  74. package/data/skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md +312 -0
  75. package/data/skills/bio-comparative-genomics-hgt-detection/SKILL.md +341 -0
  76. package/data/skills/bio-comparative-genomics-ortholog-inference/SKILL.md +308 -0
  77. package/data/skills/bio-comparative-genomics-positive-selection/SKILL.md +354 -0
  78. package/data/skills/bio-comparative-genomics-synteny-analysis/SKILL.md +315 -0
  79. package/data/skills/bio-compressed-files/SKILL.md +263 -0
  80. package/data/skills/bio-consensus-sequences/SKILL.md +340 -0
  81. package/data/skills/bio-copy-number-cnv-annotation/SKILL.md +307 -0
  82. package/data/skills/bio-copy-number-cnv-visualization/SKILL.md +294 -0
  83. package/data/skills/bio-copy-number-cnvkit-analysis/SKILL.md +290 -0
  84. package/data/skills/bio-copy-number-gatk-cnv/SKILL.md +270 -0
  85. package/data/skills/bio-crispr-screens-base-editing-analysis/SKILL.md +110 -0
  86. package/data/skills/bio-crispr-screens-batch-correction/SKILL.md +316 -0
  87. package/data/skills/bio-crispr-screens-crispresso-editing/SKILL.md +205 -0
  88. package/data/skills/bio-crispr-screens-hit-calling/SKILL.md +264 -0
  89. package/data/skills/bio-crispr-screens-jacks-analysis/SKILL.md +313 -0
  90. package/data/skills/bio-crispr-screens-library-design/SKILL.md +417 -0
  91. package/data/skills/bio-crispr-screens-mageck-analysis/SKILL.md +222 -0
  92. package/data/skills/bio-crispr-screens-screen-qc/SKILL.md +243 -0
  93. package/data/skills/bio-ctdna-mutation-detection/SKILL.md +234 -0
  94. package/data/skills/bio-data-visualization-circos-plots/SKILL.md +405 -0
  95. package/data/skills/bio-data-visualization-color-palettes/SKILL.md +244 -0
  96. package/data/skills/bio-data-visualization-genome-browser-tracks/SKILL.md +328 -0
  97. package/data/skills/bio-data-visualization-genome-tracks/SKILL.md +249 -0
  98. package/data/skills/bio-data-visualization-ggplot2-fundamentals/SKILL.md +313 -0
  99. package/data/skills/bio-data-visualization-heatmaps-clustering/SKILL.md +227 -0
  100. package/data/skills/bio-data-visualization-interactive-visualization/SKILL.md +210 -0
  101. package/data/skills/bio-data-visualization-multipanel-figures/SKILL.md +274 -0
  102. package/data/skills/bio-data-visualization-specialized-omics-plots/SKILL.md +251 -0
  103. package/data/skills/bio-data-visualization-upset-plots/SKILL.md +228 -0
  104. package/data/skills/bio-data-visualization-volcano-customization/SKILL.md +233 -0
  105. package/data/skills/bio-de-deseq2-basics/SKILL.md +376 -0
  106. package/data/skills/bio-de-edger-basics/SKILL.md +418 -0
  107. package/data/skills/bio-de-results/SKILL.md +378 -0
  108. package/data/skills/bio-de-visualization/SKILL.md +408 -0
  109. package/data/skills/bio-differential-expression-batch-correction/SKILL.md +253 -0
  110. package/data/skills/bio-differential-expression-timeseries-de/SKILL.md +370 -0
  111. package/data/skills/bio-differential-splicing/SKILL.md +177 -0
  112. package/data/skills/bio-duplicate-handling/SKILL.md +292 -0
  113. package/data/skills/bio-entrez-fetch/SKILL.md +334 -0
  114. package/data/skills/bio-entrez-link/SKILL.md +325 -0
  115. package/data/skills/bio-entrez-search/SKILL.md +311 -0
  116. package/data/skills/bio-epidemiological-genomics-amr-surveillance/SKILL.md +233 -0
  117. package/data/skills/bio-epidemiological-genomics-pathogen-typing/SKILL.md +202 -0
  118. package/data/skills/bio-epidemiological-genomics-phylodynamics/SKILL.md +207 -0
  119. package/data/skills/bio-epidemiological-genomics-transmission-inference/SKILL.md +237 -0
  120. package/data/skills/bio-epidemiological-genomics-variant-surveillance/SKILL.md +237 -0
  121. package/data/skills/bio-epitranscriptomics-m6a-differential/SKILL.md +88 -0
  122. package/data/skills/bio-epitranscriptomics-m6a-peak-calling/SKILL.md +89 -0
  123. package/data/skills/bio-epitranscriptomics-m6anet-analysis/SKILL.md +101 -0
  124. package/data/skills/bio-epitranscriptomics-merip-preprocessing/SKILL.md +81 -0
  125. package/data/skills/bio-epitranscriptomics-modification-visualization/SKILL.md +98 -0
  126. package/data/skills/bio-experimental-design-batch-design/SKILL.md +110 -0
  127. package/data/skills/bio-experimental-design-multiple-testing/SKILL.md +98 -0
  128. package/data/skills/bio-experimental-design-power-analysis/SKILL.md +84 -0
  129. package/data/skills/bio-experimental-design-sample-size/SKILL.md +93 -0
  130. package/data/skills/bio-expression-matrix-counts-ingest/SKILL.md +220 -0
  131. package/data/skills/bio-expression-matrix-gene-id-mapping/SKILL.md +256 -0
  132. package/data/skills/bio-expression-matrix-metadata-joins/SKILL.md +271 -0
  133. package/data/skills/bio-expression-matrix-sparse-handling/SKILL.md +247 -0
  134. package/data/skills/bio-fastq-quality/SKILL.md +279 -0
  135. package/data/skills/bio-filter-sequences/SKILL.md +265 -0
  136. package/data/skills/bio-flow-cytometry-bead-normalization/SKILL.md +315 -0
  137. package/data/skills/bio-flow-cytometry-clustering-phenotyping/SKILL.md +237 -0
  138. package/data/skills/bio-flow-cytometry-compensation-transformation/SKILL.md +196 -0
  139. package/data/skills/bio-flow-cytometry-cytometry-qc/SKILL.md +382 -0
  140. package/data/skills/bio-flow-cytometry-differential-analysis/SKILL.md +217 -0
  141. package/data/skills/bio-flow-cytometry-doublet-detection/SKILL.md +288 -0
  142. package/data/skills/bio-flow-cytometry-fcs-handling/SKILL.md +221 -0
  143. package/data/skills/bio-flow-cytometry-gating-analysis/SKILL.md +193 -0
  144. package/data/skills/bio-format-conversion/SKILL.md +193 -0
  145. package/data/skills/bio-fragment-analysis/SKILL.md +214 -0
  146. package/data/skills/bio-gatk-variant-calling/SKILL.md +422 -0
  147. package/data/skills/bio-genome-assembly-assembly-polishing/SKILL.md +333 -0
  148. package/data/skills/bio-genome-assembly-assembly-qc/SKILL.md +344 -0
  149. package/data/skills/bio-genome-assembly-contamination-detection/SKILL.md +235 -0
  150. package/data/skills/bio-genome-assembly-hifi-assembly/SKILL.md +178 -0
  151. package/data/skills/bio-genome-assembly-long-read-assembly/SKILL.md +307 -0
  152. package/data/skills/bio-genome-assembly-metagenome-assembly/SKILL.md +227 -0
  153. package/data/skills/bio-genome-assembly-scaffolding/SKILL.md +204 -0
  154. package/data/skills/bio-genome-assembly-short-read-assembly/SKILL.md +319 -0
  155. package/data/skills/bio-genome-engineering-base-editing-design/SKILL.md +277 -0
  156. package/data/skills/bio-genome-engineering-grna-design/SKILL.md +221 -0
  157. package/data/skills/bio-genome-engineering-hdr-template-design/SKILL.md +264 -0
  158. package/data/skills/bio-genome-engineering-off-target-prediction/SKILL.md +232 -0
  159. package/data/skills/bio-genome-engineering-prime-editing-design/SKILL.md +275 -0
  160. package/data/skills/bio-genome-intervals-bed-file-basics/SKILL.md +357 -0
  161. package/data/skills/bio-genome-intervals-bigwig-tracks/SKILL.md +351 -0
  162. package/data/skills/bio-genome-intervals-coverage-analysis/SKILL.md +300 -0
  163. package/data/skills/bio-genome-intervals-gtf-gff-handling/SKILL.md +345 -0
  164. package/data/skills/bio-genome-intervals-interval-arithmetic/SKILL.md +485 -0
  165. package/data/skills/bio-genome-intervals-proximity-operations/SKILL.md +337 -0
  166. package/data/skills/bio-geo-data/SKILL.md +380 -0
  167. package/data/skills/bio-hi-c-analysis-compartment-analysis/SKILL.md +261 -0
  168. package/data/skills/bio-hi-c-analysis-contact-pairs/SKILL.md +278 -0
  169. package/data/skills/bio-hi-c-analysis-hic-data-io/SKILL.md +260 -0
  170. package/data/skills/bio-hi-c-analysis-hic-differential/SKILL.md +328 -0
  171. package/data/skills/bio-hi-c-analysis-hic-visualization/SKILL.md +297 -0
  172. package/data/skills/bio-hi-c-analysis-loop-calling/SKILL.md +284 -0
  173. package/data/skills/bio-hi-c-analysis-matrix-operations/SKILL.md +274 -0
  174. package/data/skills/bio-hi-c-analysis-tad-detection/SKILL.md +239 -0
  175. package/data/skills/bio-imaging-mass-cytometry-cell-segmentation/SKILL.md +241 -0
  176. package/data/skills/bio-imaging-mass-cytometry-data-preprocessing/SKILL.md +279 -0
  177. package/data/skills/bio-imaging-mass-cytometry-interactive-annotation/SKILL.md +304 -0
  178. package/data/skills/bio-imaging-mass-cytometry-phenotyping/SKILL.md +231 -0
  179. package/data/skills/bio-imaging-mass-cytometry-quality-metrics/SKILL.md +316 -0
  180. package/data/skills/bio-imaging-mass-cytometry-spatial-analysis/SKILL.md +246 -0
  181. package/data/skills/bio-immunoinformatics-epitope-prediction/SKILL.md +259 -0
  182. package/data/skills/bio-immunoinformatics-immunogenicity-scoring/SKILL.md +275 -0
  183. package/data/skills/bio-immunoinformatics-mhc-binding-prediction/SKILL.md +260 -0
  184. package/data/skills/bio-immunoinformatics-neoantigen-prediction/SKILL.md +277 -0
  185. package/data/skills/bio-immunoinformatics-tcr-epitope-binding/SKILL.md +257 -0
  186. package/data/skills/bio-isoform-switching/SKILL.md +192 -0
  187. package/data/skills/bio-liquid-biopsy-pipeline/SKILL.md +311 -0
  188. package/data/skills/bio-local-blast/SKILL.md +350 -0
  189. package/data/skills/bio-long-read-sequencing-clair3-variants/SKILL.md +252 -0
  190. package/data/skills/bio-long-read-sequencing-isoseq-analysis/SKILL.md +334 -0
  191. package/data/skills/bio-long-read-sequencing-nanopore-methylation/SKILL.md +110 -0
  192. package/data/skills/bio-longitudinal-monitoring/SKILL.md +271 -0
  193. package/data/skills/bio-longread-alignment/SKILL.md +193 -0
  194. package/data/skills/bio-longread-medaka/SKILL.md +176 -0
  195. package/data/skills/bio-longread-qc/SKILL.md +224 -0
  196. package/data/skills/bio-longread-structural-variants/SKILL.md +201 -0
  197. package/data/skills/bio-machine-learning-atlas-mapping/SKILL.md +139 -0
  198. package/data/skills/bio-machine-learning-biomarker-discovery/SKILL.md +157 -0
  199. package/data/skills/bio-machine-learning-model-validation/SKILL.md +148 -0
  200. package/data/skills/bio-machine-learning-omics-classifiers/SKILL.md +146 -0
  201. package/data/skills/bio-machine-learning-prediction-explanation/SKILL.md +162 -0
  202. package/data/skills/bio-machine-learning-survival-analysis/SKILL.md +176 -0
  203. package/data/skills/bio-metabolomics-lipidomics/SKILL.md +265 -0
  204. package/data/skills/bio-metabolomics-metabolite-annotation/SKILL.md +241 -0
  205. package/data/skills/bio-metabolomics-msdial-preprocessing/SKILL.md +308 -0
  206. package/data/skills/bio-metabolomics-normalization-qc/SKILL.md +283 -0
  207. package/data/skills/bio-metabolomics-pathway-mapping/SKILL.md +237 -0
  208. package/data/skills/bio-metabolomics-statistical-analysis/SKILL.md +276 -0
  209. package/data/skills/bio-metabolomics-targeted-analysis/SKILL.md +314 -0
  210. package/data/skills/bio-metabolomics-xcms-preprocessing/SKILL.md +268 -0
  211. package/data/skills/bio-metagenomics-abundance/SKILL.md +203 -0
  212. package/data/skills/bio-metagenomics-amr-detection/SKILL.md +293 -0
  213. package/data/skills/bio-metagenomics-functional-profiling/SKILL.md +252 -0
  214. package/data/skills/bio-metagenomics-kraken/SKILL.md +204 -0
  215. package/data/skills/bio-metagenomics-metaphlan/SKILL.md +214 -0
  216. package/data/skills/bio-metagenomics-strain-tracking/SKILL.md +292 -0
  217. package/data/skills/bio-metagenomics-visualization/SKILL.md +240 -0
  218. package/data/skills/bio-methylation-based-detection/SKILL.md +223 -0
  219. package/data/skills/bio-methylation-bismark-alignment/SKILL.md +195 -0
  220. package/data/skills/bio-methylation-calling/SKILL.md +200 -0
  221. package/data/skills/bio-methylation-dmr-detection/SKILL.md +211 -0
  222. package/data/skills/bio-methylation-methylkit/SKILL.md +219 -0
  223. package/data/skills/bio-microbiome-amplicon-processing/SKILL.md +137 -0
  224. package/data/skills/bio-microbiome-differential-abundance/SKILL.md +147 -0
  225. package/data/skills/bio-microbiome-diversity-analysis/SKILL.md +188 -0
  226. package/data/skills/bio-microbiome-functional-prediction/SKILL.md +153 -0
  227. package/data/skills/bio-microbiome-qiime2-workflow/SKILL.md +219 -0
  228. package/data/skills/bio-microbiome-taxonomy-assignment/SKILL.md +168 -0
  229. package/data/skills/bio-molecular-descriptors/SKILL.md +200 -0
  230. package/data/skills/bio-molecular-io/SKILL.md +188 -0
  231. package/data/skills/bio-motif-search/SKILL.md +354 -0
  232. package/data/skills/bio-multi-omics-data-harmonization/SKILL.md +228 -0
  233. package/data/skills/bio-multi-omics-mixomics-analysis/SKILL.md +221 -0
  234. package/data/skills/bio-multi-omics-mofa-integration/SKILL.md +225 -0
  235. package/data/skills/bio-multi-omics-similarity-network/SKILL.md +235 -0
  236. package/data/skills/bio-orchestrator/SKILL.md +133 -0
  237. package/data/skills/bio-paired-end-fastq/SKILL.md +334 -0
  238. package/data/skills/bio-pathway-enrichment-visualization/SKILL.md +278 -0
  239. package/data/skills/bio-pathway-go-enrichment/SKILL.md +218 -0
  240. package/data/skills/bio-pathway-gsea/SKILL.md +227 -0
  241. package/data/skills/bio-pathway-kegg-pathways/SKILL.md +234 -0
  242. package/data/skills/bio-pathway-reactome/SKILL.md +215 -0
  243. package/data/skills/bio-pathway-wikipathways/SKILL.md +255 -0
  244. package/data/skills/bio-pdb-geometric-analysis/SKILL.md +475 -0
  245. package/data/skills/bio-pdb-structure-io/SKILL.md +296 -0
  246. package/data/skills/bio-pdb-structure-modification/SKILL.md +448 -0
  247. package/data/skills/bio-pdb-structure-navigation/SKILL.md +335 -0
  248. package/data/skills/bio-phasing-imputation-genotype-imputation/SKILL.md +201 -0
  249. package/data/skills/bio-phasing-imputation-haplotype-phasing/SKILL.md +190 -0
  250. package/data/skills/bio-phasing-imputation-imputation-qc/SKILL.md +265 -0
  251. package/data/skills/bio-phasing-imputation-reference-panels/SKILL.md +203 -0
  252. package/data/skills/bio-phylo-distance-calculations/SKILL.md +307 -0
  253. package/data/skills/bio-phylo-modern-tree-inference/SKILL.md +274 -0
  254. package/data/skills/bio-phylo-tree-io/SKILL.md +252 -0
  255. package/data/skills/bio-phylo-tree-manipulation/SKILL.md +375 -0
  256. package/data/skills/bio-phylo-tree-visualization/SKILL.md +275 -0
  257. package/data/skills/bio-pileup-generation/SKILL.md +314 -0
  258. package/data/skills/bio-population-genetics-association-testing/SKILL.md +293 -0
  259. package/data/skills/bio-population-genetics-linkage-disequilibrium/SKILL.md +260 -0
  260. package/data/skills/bio-population-genetics-plink-basics/SKILL.md +338 -0
  261. package/data/skills/bio-population-genetics-population-structure/SKILL.md +352 -0
  262. package/data/skills/bio-population-genetics-scikit-allel-analysis/SKILL.md +306 -0
  263. package/data/skills/bio-population-genetics-selection-statistics/SKILL.md +251 -0
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  1266. package/dist/bgi.js +128 -2
  1267. package/package.json +2 -1
@@ -0,0 +1,175 @@
1
+ """
2
+ ============================================================================
3
+ LOAD SPATIAL TRANSCRIPTOMICS DATA
4
+ ============================================================================
5
+
6
+ Functions:
7
+ - load_visium_heart(): Load V1_Human_Heart example dataset from 10x Genomics
8
+ - load_visium_data(): Load user-provided Visium data (h5ad or Space Ranger)
9
+
10
+ Usage:
11
+ from load_example_data import load_visium_heart
12
+ adata = load_visium_heart()
13
+ """
14
+
15
+ from pathlib import Path
16
+ from typing import Optional, Union
17
+
18
+
19
+ def load_visium_heart() -> 'anndata.AnnData':
20
+ """
21
+ Load V1_Human_Heart Visium dataset from 10x Genomics.
22
+
23
+ Downloads the processed dataset via scanpy's built-in datasets module.
24
+ Contains ~4,247 spots and ~33,538 genes with H&E tissue image.
25
+
26
+ Returns
27
+ -------
28
+ AnnData
29
+ Visium spatial transcriptomics data with:
30
+ - .X: count matrix (spots x genes)
31
+ - .obs: spot metadata
32
+ - .obsm['spatial']: spatial coordinates
33
+ - .uns['spatial']: tissue image and scalefactors
34
+ """
35
+ import scanpy as sc
36
+
37
+ print("Loading V1_Human_Heart Visium dataset...")
38
+ print(" Source: 10x Genomics Spatial Gene Expression")
39
+ print(" Description: Human heart tissue section")
40
+ print(" Platform: Visium Spatial Gene Expression")
41
+ print(" (First run downloads ~50 MB, subsequent runs use cache)")
42
+
43
+ try:
44
+ adata = sc.datasets.visium_sge(sample_id="V1_Human_Heart")
45
+ except AttributeError:
46
+ # Fallback for Python <3.12 (tarfile.data_filter not available)
47
+ print(" Using manual download fallback...")
48
+ adata = _download_visium_manual("V1_Human_Heart")
49
+
50
+ # Make variable names unique (critical for some Visium datasets)
51
+ adata.var_names_make_unique()
52
+
53
+ # Report dataset summary
54
+ has_image = 'spatial' in adata.uns and len(adata.uns['spatial']) > 0
55
+
56
+ print(f"\n✓ Data loaded successfully!")
57
+ print(f" Spots: {adata.n_obs}")
58
+ print(f" Genes: {adata.n_vars}")
59
+ print(f" Spatial image: {'Yes' if has_image else 'No'}")
60
+ if 'spatial' in adata.obsm:
61
+ print(f" Spatial coordinates: {adata.obsm['spatial'].shape}")
62
+
63
+ return adata
64
+
65
+
66
+ def _download_file(url: str, dest: Path) -> None:
67
+ """Download a file with proper User-Agent header."""
68
+ import urllib.request
69
+
70
+ req = urllib.request.Request(url, headers={
71
+ 'User-Agent': 'Mozilla/5.0 (compatible; scanpy-downloader)'
72
+ })
73
+ with urllib.request.urlopen(req) as response, open(dest, 'wb') as out:
74
+ while True:
75
+ chunk = response.read(8192)
76
+ if not chunk:
77
+ break
78
+ out.write(chunk)
79
+
80
+
81
+ def _download_visium_manual(sample_id: str) -> 'anndata.AnnData':
82
+ """Manual Visium dataset download for Python <3.12 compatibility."""
83
+ import scanpy as sc
84
+ import tarfile
85
+
86
+ base_url = "https://cf.10xgenomics.com/samples/spatial-exp/1.1.0"
87
+
88
+ cache_dir = Path(sc.settings.datasetdir) / sample_id
89
+ cache_dir.mkdir(parents=True, exist_ok=True)
90
+
91
+ # Download H5 file (required by sc.read_visium)
92
+ h5_path = cache_dir / "filtered_feature_bc_matrix.h5"
93
+ if not h5_path.exists():
94
+ h5_url = f"{base_url}/{sample_id}/{sample_id}_filtered_feature_bc_matrix.h5"
95
+ print(f" Downloading filtered feature-barcode matrix (H5)...")
96
+ _download_file(h5_url, h5_path)
97
+
98
+ # Download and extract spatial data
99
+ spatial_dir = cache_dir / "spatial"
100
+ if not spatial_dir.exists():
101
+ spatial_url = f"{base_url}/{sample_id}/{sample_id}_spatial.tar.gz"
102
+ print(f" Downloading spatial data...")
103
+ tar_path = cache_dir / "spatial.tar.gz"
104
+ _download_file(spatial_url, tar_path)
105
+ with tarfile.open(tar_path, 'r:gz') as tf:
106
+ tf.extractall(cache_dir)
107
+ tar_path.unlink()
108
+
109
+ adata = sc.read_visium(cache_dir)
110
+ return adata
111
+
112
+
113
+ def load_visium_data(
114
+ path: Union[str, Path],
115
+ library_id: Optional[str] = None
116
+ ) -> 'anndata.AnnData':
117
+ """
118
+ Load user-provided Visium data.
119
+
120
+ Supports:
121
+ - .h5ad files (AnnData format)
122
+ - Space Ranger output directory (with filtered_feature_bc_matrix/)
123
+ - .h5 files (10x HDF5 format)
124
+
125
+ Parameters
126
+ ----------
127
+ path : str or Path
128
+ Path to data file or Space Ranger output directory.
129
+ library_id : str, optional
130
+ Library ID for Space Ranger output.
131
+
132
+ Returns
133
+ -------
134
+ AnnData
135
+ Loaded spatial data with spatial coordinates.
136
+ """
137
+ import scanpy as sc
138
+
139
+ path = Path(path)
140
+
141
+ if not path.exists():
142
+ raise FileNotFoundError(f"Path not found: {path}")
143
+
144
+ if path.suffix == '.h5ad':
145
+ print(f"Loading AnnData from {path}...")
146
+ adata = sc.read_h5ad(path)
147
+ elif path.suffix == '.h5':
148
+ print(f"Loading 10x HDF5 from {path}...")
149
+ adata = sc.read_10x_h5(path)
150
+ elif path.is_dir():
151
+ print(f"Loading Space Ranger output from {path}...")
152
+ adata = sc.read_visium(path, library_id=library_id)
153
+ else:
154
+ raise ValueError(
155
+ f"Unsupported format: {path.suffix}. "
156
+ "Expected .h5ad, .h5, or Space Ranger output directory."
157
+ )
158
+
159
+ adata.var_names_make_unique()
160
+
161
+ has_image = 'spatial' in adata.uns and len(adata.uns['spatial']) > 0
162
+
163
+ print(f"\n✓ Data loaded successfully!")
164
+ print(f" Spots: {adata.n_obs}")
165
+ print(f" Genes: {adata.n_vars}")
166
+ print(f" Spatial image: {'Yes' if has_image else 'No'}")
167
+ if 'spatial' in adata.obsm:
168
+ print(f" Spatial coordinates: {adata.obsm['spatial'].shape}")
169
+
170
+ return adata
171
+
172
+
173
+ if __name__ == "__main__":
174
+ adata = load_visium_heart()
175
+ print("\nExample data ready for spatial analysis!")
@@ -0,0 +1,206 @@
1
+ """
2
+ ============================================================================
3
+ SPATIAL TRANSCRIPTOMICS ANALYSIS WORKFLOW
4
+ ============================================================================
5
+
6
+ Complete Visium spatial analysis: QC -> filtering -> normalization ->
7
+ clustering -> spatial neighbors -> SVGs -> neighborhood enrichment ->
8
+ co-occurrence.
9
+
10
+ Functions:
11
+ - run_spatial_analysis(): Execute complete spatial workflow
12
+
13
+ Usage:
14
+ from spatial_workflow import run_spatial_analysis
15
+ adata = run_spatial_analysis(adata)
16
+ """
17
+
18
+ import numpy as np
19
+ import pandas as pd
20
+ from typing import Optional, List
21
+
22
+
23
+ def run_spatial_analysis(
24
+ adata: 'anndata.AnnData',
25
+ min_genes: int = 200,
26
+ min_cells: int = 10,
27
+ max_pct_mito: float = 50.0,
28
+ n_top_genes: int = 2000,
29
+ n_pcs: int = 30,
30
+ resolution: float = 0.8,
31
+ n_neighbors: int = 15,
32
+ svgs_n_perms: int = 100,
33
+ svgs_n_jobs: int = 1,
34
+ output_dir: str = "visium_results"
35
+ ) -> 'anndata.AnnData':
36
+ """
37
+ Run complete spatial transcriptomics analysis.
38
+
39
+ Pipeline:
40
+ 1. QC metrics (mitochondrial %, total counts, genes per spot)
41
+ 2. Filter spots (min_genes, max_mito)
42
+ 3. Normalize + log1p
43
+ 4. HVG selection (seurat_v3 on raw counts)
44
+ 5. PCA + Neighbors + UMAP + Leiden clustering
45
+ 6. Spatial neighbors graph
46
+ 7. Spatially variable genes (Moran's I)
47
+ 8. Neighborhood enrichment
48
+ 9. Co-occurrence analysis
49
+
50
+ Parameters
51
+ ----------
52
+ adata : AnnData
53
+ Raw Visium data (from load_example_data).
54
+ min_genes : int
55
+ Minimum genes per spot (default: 200).
56
+ min_cells : int
57
+ Minimum spots per gene (default: 10).
58
+ max_pct_mito : float
59
+ Maximum mitochondrial percentage (default: 50.0; heart tissue is MT-rich).
60
+ n_top_genes : int
61
+ Number of highly variable genes (default: 2000).
62
+ n_pcs : int
63
+ Number of PCA components (default: 30).
64
+ resolution : float
65
+ Leiden clustering resolution (default: 0.8).
66
+ n_neighbors : int
67
+ Number of neighbors for expression graph (default: 15).
68
+ svgs_n_perms : int
69
+ Permutations for Moran's I (default: 100).
70
+ svgs_n_jobs : int
71
+ Parallel jobs for Moran's I (default: 1).
72
+ output_dir : str
73
+ Output directory (default: "visium_results").
74
+
75
+ Returns
76
+ -------
77
+ AnnData
78
+ Processed adata with clustering, SVGs, enrichment results attached.
79
+ """
80
+ import scanpy as sc
81
+ import squidpy as sq
82
+ import os
83
+
84
+ os.makedirs(output_dir, exist_ok=True)
85
+
86
+ print("\n=== Step 2: Spatial Transcriptomics Analysis ===\n")
87
+ n_spots_initial = adata.n_obs
88
+
89
+ # --- 1. QC metrics ---
90
+ print("1. Calculating QC metrics...")
91
+ adata.var['mt'] = adata.var_names.str.startswith('MT-')
92
+ sc.pp.calculate_qc_metrics(
93
+ adata, qc_vars=['mt'], percent_top=None, log1p=False, inplace=True
94
+ )
95
+ print(f" Median genes/spot: {adata.obs['n_genes_by_counts'].median():.0f}")
96
+ print(f" Median counts/spot: {adata.obs['total_counts'].median():.0f}")
97
+ print(f" Median %MT: {adata.obs['pct_counts_mt'].median():.1f}%")
98
+
99
+ # --- 2. Filter spots ---
100
+ print(f"\n2. Filtering spots (min_genes={min_genes}, max_mito={max_pct_mito}%)...")
101
+
102
+ # Store raw counts BEFORE any processing
103
+ adata.layers['counts'] = adata.X.copy()
104
+
105
+ sc.pp.filter_cells(adata, min_genes=min_genes)
106
+ sc.pp.filter_genes(adata, min_cells=min_cells)
107
+ adata = adata[adata.obs['pct_counts_mt'] < max_pct_mito, :].copy()
108
+
109
+ n_spots_after = adata.n_obs
110
+ retention = 100 * n_spots_after / n_spots_initial
111
+ print(f" Spots: {n_spots_initial} -> {n_spots_after} ({retention:.1f}% retained)")
112
+
113
+ # --- 3. Normalize ---
114
+ print("\n3. Normalizing (target sum + log1p)...")
115
+ sc.pp.normalize_total(adata, target_sum=1e4)
116
+ sc.pp.log1p(adata)
117
+
118
+ # Store normalized counts for SVG computation later
119
+ adata.layers['normalized'] = adata.X.copy()
120
+
121
+ # --- 4. HVG selection ---
122
+ print(f"\n4. Selecting {n_top_genes} highly variable genes...")
123
+ sc.pp.highly_variable_genes(
124
+ adata, n_top_genes=n_top_genes, flavor='seurat_v3',
125
+ layer='counts'
126
+ )
127
+ n_hvgs = adata.var['highly_variable'].sum()
128
+ print(f" Highly variable genes: {n_hvgs}")
129
+
130
+ # --- 5. PCA + Neighbors + UMAP + Leiden ---
131
+ print("\n5. Dimensionality reduction and clustering...")
132
+ sc.pp.scale(adata, max_value=10)
133
+ sc.tl.pca(adata, n_comps=n_pcs, svd_solver='arpack')
134
+ sc.pp.neighbors(adata, n_neighbors=n_neighbors, n_pcs=n_pcs)
135
+ sc.tl.umap(adata)
136
+ sc.tl.leiden(adata, resolution=resolution, key_added='leiden')
137
+
138
+ n_clusters = adata.obs['leiden'].nunique()
139
+ print(f" PCA: {n_pcs} components")
140
+ print(f" Leiden clusters: {n_clusters} (resolution={resolution})")
141
+
142
+ # --- 6. Spatial neighbors ---
143
+ print("\n6. Building spatial neighbors graph...")
144
+ sq.gr.spatial_neighbors(adata, coord_type='grid', n_neighs=6)
145
+ n_edges = adata.obsp['spatial_connectivities'].nnz
146
+ print(f" Spatial graph: {n_edges} edges")
147
+
148
+ # --- 7. Spatially variable genes (Moran's I) ---
149
+ print(f"\n7. Computing spatially variable genes (Moran's I, n_perms={svgs_n_perms})...")
150
+
151
+ # Restore normalized expression for SVG computation (scale modifies X)
152
+ adata.X = adata.layers['normalized'].copy()
153
+
154
+ sq.gr.spatial_autocorr(
155
+ adata,
156
+ mode='moran',
157
+ n_perms=svgs_n_perms,
158
+ n_jobs=svgs_n_jobs
159
+ )
160
+
161
+ # Extract significant SVGs
162
+ moranI = adata.uns['moranI'].copy()
163
+ svgs = moranI[moranI['pval_norm_fdr_bh'] < 0.05].sort_values('I', ascending=False)
164
+ n_svgs = len(svgs)
165
+ print(f" Spatially variable genes (FDR < 0.05): {n_svgs}")
166
+ if n_svgs > 0:
167
+ top5 = svgs.index[:5].tolist()
168
+ print(f" Top SVGs: {', '.join(top5)}")
169
+
170
+ # Store SVG results
171
+ adata.uns['svg_results'] = svgs
172
+
173
+ # --- 8. Neighborhood enrichment ---
174
+ print("\n8. Computing neighborhood enrichment...")
175
+ sq.gr.nhood_enrichment(adata, cluster_key='leiden')
176
+ print(f" Enrichment matrix: {n_clusters}x{n_clusters}")
177
+
178
+ # --- 9. Co-occurrence ---
179
+ print("\n9. Computing co-occurrence scores...")
180
+ sq.gr.co_occurrence(adata, cluster_key='leiden')
181
+ print(f" Co-occurrence computed for {n_clusters} clusters")
182
+
183
+ # --- Store analysis parameters ---
184
+ adata.uns['spatial_analysis_params'] = {
185
+ 'min_genes': min_genes,
186
+ 'min_cells': min_cells,
187
+ 'max_pct_mito': max_pct_mito,
188
+ 'n_top_genes': n_top_genes,
189
+ 'n_pcs': n_pcs,
190
+ 'resolution': resolution,
191
+ 'n_neighbors': n_neighbors,
192
+ 'svgs_n_perms': svgs_n_perms,
193
+ 'n_spots_initial': int(n_spots_initial),
194
+ 'n_spots_after': int(n_spots_after),
195
+ 'n_clusters': int(n_clusters),
196
+ 'n_svgs': int(n_svgs),
197
+ }
198
+
199
+ print("\n" + "=" * 50)
200
+ print("✓ Spatial analysis completed successfully!")
201
+ print("=" * 50)
202
+ print(f"\n Spots analyzed: {n_spots_after}")
203
+ print(f" Clusters found: {n_clusters}")
204
+ print(f" SVGs identified: {n_svgs}")
205
+
206
+ return adata
package/dist/bgi.js CHANGED
@@ -13930,6 +13930,33 @@ async function streamOnce(client, messages, model) {
13930
13930
  finishReason
13931
13931
  };
13932
13932
  }
13933
+ async function compactMessages(messages, config) {
13934
+ const prov = PROVIDERS[config.provider];
13935
+ if (!prov) throw new Error(`Unknown provider: ${config.provider}`);
13936
+ const baseURL = config.provider === "custom" ? config.customUrl : prov.baseURL;
13937
+ const apiKey = getApiKey(config);
13938
+ const client = new openai_default({ apiKey: apiKey || "none", baseURL });
13939
+ const transcript = messages.filter((m2) => m2.role === "user" || m2.role === "assistant").map((m2) => `[${m2.role === "user" ? "\u7528\u6237" : "AI"}]: ${String(m2.content ?? "").slice(0, 2e3)}`).join("\n\n");
13940
+ const resp = await client.chat.completions.create({
13941
+ model: config.model,
13942
+ messages: [
13943
+ {
13944
+ role: "system",
13945
+ content: "\u4F60\u662F\u4E00\u4E2A\u5BF9\u8BDD\u6458\u8981\u52A9\u624B\u3002\u8BF7\u5C06\u4EE5\u4E0B\u5BF9\u8BDD\u5386\u53F2\u538B\u7F29\u4E3A\u7B80\u6D01\u7684\u4E2D\u6587\u6458\u8981\uFF0C\u4FDD\u7559\u6240\u6709\u5173\u952E\u6280\u672F\u4FE1\u606F\uFF1A\u6587\u4EF6\u8DEF\u5F84\u3001\u547D\u4EE4\u3001\u5206\u6790\u7ED3\u679C\u3001\u7528\u6237\u51B3\u7B56\u3001\u5DF2\u6FC0\u6D3B\u7684\u5DE5\u4F5C\u6D41/\u6280\u80FD\u3002\u6458\u8981\u5E94\u8BA9\u5BF9\u8BDD\u80FD\u591F\u65E0\u7F1D\u7EE7\u7EED\u3002"
13946
+ },
13947
+ {
13948
+ role: "user",
13949
+ content: `\u8BF7\u538B\u7F29\u4EE5\u4E0B\u5BF9\u8BDD\u5386\u53F2\uFF1A
13950
+
13951
+ ${transcript}
13952
+
13953
+ \u8F93\u51FA\u683C\u5F0F\uFF1A\u76F4\u63A5\u8F93\u51FA\u6458\u8981\u6587\u672C\uFF0C\u4E0D\u9700\u8981\u4EFB\u4F55\u524D\u7F00\u3002`
13954
+ }
13955
+ ],
13956
+ stream: false
13957
+ });
13958
+ return resp.choices[0]?.message?.content ?? "\uFF08\u5BF9\u8BDD\u5386\u53F2\u5DF2\u538B\u7F29\uFF09";
13959
+ }
13933
13960
  function getApiKey(cfg) {
13934
13961
  const prov = PROVIDERS[cfg.provider];
13935
13962
  if (prov?.envKey && process.env[prov.envKey]) return process.env[prov.envKey];
@@ -14657,7 +14684,33 @@ function routeSkill(message) {
14657
14684
  }
14658
14685
 
14659
14686
  // src/index.ts
14660
- var VERSION2 = "2.1.0";
14687
+ var VERSION2 = "2.2.0";
14688
+ function installBundledData() {
14689
+ const bundledData = (0, import_path4.join)(__dirname, "..", "data");
14690
+ if (!(0, import_fs4.existsSync)(bundledData)) return;
14691
+ ensureDirs();
14692
+ const targets = [
14693
+ { src: (0, import_path4.join)(bundledData, "workflows"), dest: WORKFLOWS_DIR, name: "\u5DE5\u4F5C\u6D41" },
14694
+ { src: (0, import_path4.join)(bundledData, "skills"), dest: SKILLS_DIR, name: "OpenClaw Skills" },
14695
+ { src: (0, import_path4.join)(bundledData, "tools"), dest: TOOLS_DIR, name: "\u5DE5\u5177" }
14696
+ ];
14697
+ let installed = false;
14698
+ for (const { src, dest, name } of targets) {
14699
+ if (!(0, import_fs4.existsSync)(src)) continue;
14700
+ const isEmpty = !(0, import_fs4.existsSync)(dest) || (0, import_fs4.readdirSync)(dest).length === 0;
14701
+ if (isEmpty) {
14702
+ (0, import_fs4.mkdirSync)(dest, { recursive: true });
14703
+ (0, import_fs4.cpSync)(src, dest, { recursive: true });
14704
+ if (!installed) {
14705
+ process.stdout.write(source_default.dim("\u6B63\u5728\u521D\u59CB\u5316\u5185\u7F6E\u6570\u636E...\n"));
14706
+ installed = true;
14707
+ }
14708
+ process.stdout.write(source_default.green(` \u2713 ${name} \u5DF2\u5B89\u88C5
14709
+ `));
14710
+ }
14711
+ }
14712
+ if (installed) console.log();
14713
+ }
14661
14714
  function printBanner() {
14662
14715
  console.log(source_default.cyan.bold(`
14663
14716
  \u2588\u2588\u2588\u2588\u2588\u2588\u2557 \u2588\u2588\u2588\u2588\u2588\u2588\u2557 \u2588\u2588\u2557 \u2588\u2588\u2588\u2588\u2588\u2588\u2557\u2588\u2588\u2557 \u2588\u2588\u2557
@@ -14681,6 +14734,7 @@ function printHelp() {
14681
14734
  console.log(source_default.bold.cyan("\u2500\u2500\u2500 \u5BF9\u8BDD\u7BA1\u7406 \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500"));
14682
14735
  console.log(` ${source_default.cyan("/clear")} \u6E05\u7A7A\u5BF9\u8BDD\u5386\u53F2`);
14683
14736
  console.log(` ${source_default.cyan("/history")} \u67E5\u770B\u5BF9\u8BDD\u7EDF\u8BA1\uFF08\u8F6E\u6B21 / Token \u4F30\u7B97\uFF09`);
14737
+ console.log(` ${source_default.cyan("/compact")} \u7ACB\u5373\u538B\u7F29\u5BF9\u8BDD\u5386\u53F2\uFF08\u8D85 60k token \u81EA\u52A8\u89E6\u53D1\uFF09`);
14684
14738
  console.log(` ${source_default.cyan("/save")} [\u6587\u4EF6\u540D] \u4FDD\u5B58\u5BF9\u8BDD\u4E3A Markdown \u6587\u4EF6`);
14685
14739
  console.log(` ${source_default.cyan("/think")} [on|off] \u5207\u6362\u601D\u8003\u6A21\u5F0F (Qwen3 /think \u524D\u7F00)`);
14686
14740
  console.log();
@@ -14908,6 +14962,45 @@ ${msg.content}
14908
14962
  (0, import_fs4.writeFileSync)(outPath, lines.join("\n"), "utf8");
14909
14963
  console.log(source_default.green(`\u2713 \u5BF9\u8BDD\u5DF2\u4FDD\u5B58: ${outPath}`));
14910
14964
  }
14965
+ var COMPACT_TOKEN_THRESHOLD = 6e4;
14966
+ var COMPACT_KEEP_RECENT = 8;
14967
+ function estimateTokens(messages) {
14968
+ const chars = messages.reduce((n2, m2) => n2 + String(m2.content ?? "").length, 0);
14969
+ return Math.round(chars / 3.5);
14970
+ }
14971
+ async function maybeCompact(history, cfg) {
14972
+ const tokens = estimateTokens(history);
14973
+ if (tokens < COMPACT_TOKEN_THRESHOLD) return history;
14974
+ const recent = history.slice(-COMPACT_KEEP_RECENT);
14975
+ const old = history.slice(0, -COMPACT_KEEP_RECENT);
14976
+ if (old.length === 0) return history;
14977
+ process.stdout.write(source_default.dim(`
14978
+ [\u4E0A\u4E0B\u6587\u5DF2\u8FBE ~${Math.round(tokens / 1e3)}k tokens\uFF0C\u6B63\u5728\u81EA\u52A8\u538B\u7F29...]
14979
+ `));
14980
+ try {
14981
+ const summary = await compactMessages(old, cfg);
14982
+ const compacted = [
14983
+ {
14984
+ role: "user",
14985
+ content: `[\u5BF9\u8BDD\u5386\u53F2\u6458\u8981 \u2014 \u8BF7\u5728\u6B64\u57FA\u7840\u4E0A\u7EE7\u7EED]
14986
+
14987
+ ${summary}`
14988
+ },
14989
+ {
14990
+ role: "assistant",
14991
+ content: "\u2713 \u5DF2\u7406\u89E3\u4E4B\u524D\u7684\u5BF9\u8BDD\u6458\u8981\uFF0C\u8BF7\u7EE7\u7EED\u3002"
14992
+ },
14993
+ ...recent
14994
+ ];
14995
+ const saved = estimateTokens(history) - estimateTokens(compacted);
14996
+ process.stdout.write(source_default.dim(`[\u538B\u7F29\u5B8C\u6210\uFF0C\u91CA\u653E\u7EA6 ~${Math.round(saved / 1e3)}k tokens]
14997
+
14998
+ `));
14999
+ return compacted;
15000
+ } catch {
15001
+ return history.slice(-COMPACT_KEEP_RECENT * 2);
15002
+ }
15003
+ }
14911
15004
  async function handleCommand(input, rl, history, thinkMode) {
14912
15005
  const [cmd, ...rest] = input.slice(1).trim().split(/\s+/);
14913
15006
  const arg = rest.join(" ");
@@ -15011,6 +15104,37 @@ async function handleCommand(input, rl, history, thinkMode) {
15011
15104
  saveConversation(history, arg || void 0);
15012
15105
  break;
15013
15106
  }
15107
+ case "compact": {
15108
+ const tokens = estimateTokens(history);
15109
+ if (history.length < 4) {
15110
+ console.log(source_default.dim("\u5BF9\u8BDD\u592A\u77ED\uFF0C\u65E0\u9700\u538B\u7F29"));
15111
+ break;
15112
+ }
15113
+ console.log(source_default.dim(`\u5F53\u524D\u5BF9\u8BDD\u7EA6 ~${Math.round(tokens / 1e3)}k tokens\uFF0C\u6B63\u5728\u538B\u7F29...`));
15114
+ try {
15115
+ const currentCfg = loadConfig();
15116
+ const recent = history.slice(-COMPACT_KEEP_RECENT);
15117
+ const old = history.slice(0, -COMPACT_KEEP_RECENT);
15118
+ if (old.length === 0) {
15119
+ console.log(source_default.dim("\u8FD1\u671F\u6D88\u606F\u4E0D\u8DB3\uFF0C\u65E0\u9700\u538B\u7F29"));
15120
+ break;
15121
+ }
15122
+ const summary = await compactMessages(old, currentCfg);
15123
+ const newHistory = [
15124
+ { role: "user", content: `[\u5BF9\u8BDD\u5386\u53F2\u6458\u8981 \u2014 \u8BF7\u5728\u6B64\u57FA\u7840\u4E0A\u7EE7\u7EED]
15125
+
15126
+ ${summary}` },
15127
+ { role: "assistant", content: "\u2713 \u5DF2\u7406\u89E3\u4E4B\u524D\u7684\u5BF9\u8BDD\u6458\u8981\uFF0C\u8BF7\u7EE7\u7EED\u3002" },
15128
+ ...recent
15129
+ ];
15130
+ const after = estimateTokens(newHistory);
15131
+ console.log(source_default.green(`\u2713 \u538B\u7F29\u5B8C\u6210: ${history.length} \u6761\u6D88\u606F \u2192 ${newHistory.length} \u6761\uFF0C~${Math.round(after / 1e3)}k tokens`));
15132
+ return { injectHistory: newHistory };
15133
+ } catch (err) {
15134
+ console.error(source_default.red(`\u538B\u7F29\u5931\u8D25: ${err instanceof Error ? err.message : String(err)}`));
15135
+ }
15136
+ break;
15137
+ }
15014
15138
  case "think": {
15015
15139
  const val = arg.toLowerCase();
15016
15140
  if (val === "on" || val === "1" || val === "true") {
@@ -15105,6 +15229,7 @@ async function handleCommand(input, rl, history, thinkMode) {
15105
15229
  return {};
15106
15230
  }
15107
15231
  async function main() {
15232
+ installBundledData();
15108
15233
  printBanner();
15109
15234
  const rl = (0, import_readline.createInterface)({
15110
15235
  input: process.stdin,
@@ -15155,6 +15280,7 @@ async function main() {
15155
15280
  history = [];
15156
15281
  injectedSkills.clear();
15157
15282
  }
15283
+ if (result.injectHistory) history = result.injectHistory;
15158
15284
  if (result.thinkMode !== void 0) thinkMode = result.thinkMode;
15159
15285
  continue;
15160
15286
  }
@@ -15183,7 +15309,7 @@ ${expanded}` : expanded;
15183
15309
  const currentCfg = loadConfig();
15184
15310
  const reply = await chat(history, currentCfg, systemPrompt);
15185
15311
  history.push({ role: "assistant", content: reply });
15186
- if (history.length > 40) history = history.slice(-40);
15312
+ history = await maybeCompact(history, currentCfg);
15187
15313
  } catch (err) {
15188
15314
  const msg = err instanceof Error ? err.message : String(err);
15189
15315
  console.error(source_default.red(`
package/package.json CHANGED
@@ -1,12 +1,13 @@
1
1
  {
2
2
  "name": "@bgicli/bgicli",
3
- "version": "2.1.1",
3
+ "version": "2.2.1",
4
4
  "description": "BGI CLI — Bioinformatics AI terminal for Chinese researchers (百炼/DeepSeek/Kimi/Qwen)",
5
5
  "bin": {
6
6
  "bgi": "dist/bgi.js"
7
7
  },
8
8
  "files": [
9
9
  "dist/bgi.js",
10
+ "data/",
10
11
  "README.md"
11
12
  ],
12
13
  "publishConfig": {