@bgicli/bgicli 2.1.1 → 2.2.1

package/data/skills/tooluniverse-disease-research/SKILL.md

@@ -0,0 +1,630 @@
+---
+name: tooluniverse-disease-research
+description: Generate comprehensive disease research reports using 100+ ToolUniverse tools. Creates a detailed markdown report file and progressively updates it with findings from 10 research dimensions. All information includes source references. Use when users ask about diseases, syndromes, or need systematic disease analysis.
+---
+
+# ToolUniverse Disease Research
+
+Generate a comprehensive, detailed disease research report with full source citations. The report is created as a markdown file and progressively updated during research.
+
+**IMPORTANT**: Always use English disease names and search terms in tool calls, even if the user writes in another language. Only try original-language terms as a fallback if English returns no results. Respond in the user's language.
+
+## When to Use
+
+Apply when the user:
+- Asks about any disease, syndrome, or medical condition
+- Needs comprehensive disease intelligence
+- Wants a detailed research report with citations
+- Asks "what do we know about [disease]?"
+
+## Core Workflow: Report-First Approach
+
+**DO NOT** show the search process to the user. Instead:
+
+1. **Create report file first** - Initialize `{disease_name}_research_report.md`
+2. **Research each dimension** - Use all relevant tools
+3. **Update report progressively** - Write findings to file after each dimension
+4. **Include citations** - Every fact must reference its source tool
+
+```
+User: "Research Parkinson's disease"
+
+Agent Actions (internal, not shown to user):
+1. Create "parkinsons_disease_research_report.md" with template
+2. Research DIM 1 → Update Identity section
+3. Research DIM 2 → Update Clinical section
+4. ... continue for all 10 dimensions
+5. Present final report to user
+```
+
+## Report Template
+
+Create this file structure at the start:
+
+```markdown
+# Disease Research Report: {Disease Name}
+
+**Report Generated**: {date}
+**Disease Identifiers**: (to be filled)
+
+---
+
+## Executive Summary
+
+(Brief 3-5 sentence overview - fill after all research complete)
+
+---
+
+## 1. Disease Identity & Classification
+
+### Ontology Identifiers
+| System | ID | Source |
+|--------|-----|--------|
+| EFO | | |
+| ICD-10 | | |
+| UMLS CUI | | |
+| SNOMED CT | | |
+
+### Synonyms & Alternative Names
+- (list with source)
+
+### Disease Hierarchy
+- Parent: 
+- Subtypes:
+
+**Sources**: (list tools used)
+
+---
+
+## 2. Clinical Presentation
+
+### Phenotypes (HPO)
+| HPO ID | Phenotype | Description | Source |
+|--------|-----------|-------------|--------|
+
+### Symptoms & Signs
+- (list with source)
+
+### Diagnostic Criteria
+- (from literature/MedlinePlus)
+
+**Sources**: (list tools used)
+
+---
+
+## 3. Genetic & Molecular Basis
+
+### Associated Genes
+| Gene | Score | Ensembl ID | Evidence | Source |
+|------|-------|------------|----------|--------|
+
+### GWAS Associations
+| SNP | P-value | Odds Ratio | Study | Source |
+|-----|---------|------------|-------|--------|
+
+### Pathogenic Variants (ClinVar)
+| Variant | Clinical Significance | Condition | Source |
+|---------|----------------------|-----------|--------|
+
+**Sources**: (list tools used)
+
+---
+
+## 4. Treatment Landscape
+
+### Approved Drugs
+| Drug | ChEMBL ID | Mechanism | Phase | Target | Source |
+|------|-----------|-----------|-------|--------|--------|
+
+### Clinical Trials
+| NCT ID | Title | Phase | Status | Intervention | Source |
+|--------|-------|-------|--------|--------------|--------|
+
+### Treatment Guidelines
+- (from literature)
+
+**Sources**: (list tools used)
+
+---
+
+## 5. Biological Pathways & Mechanisms
+
+### Key Pathways
+| Pathway | Reactome ID | Genes Involved | Source |
+|---------|-------------|----------------|--------|
+
+### Protein-Protein Interactions
+- (tissue-specific networks)
+
+### Expression Patterns
+| Tissue | Expression Level | Source |
+|--------|------------------|--------|
+
+**Sources**: (list tools used)
+
+---
+
+## 6. Epidemiology & Risk Factors
+
+### Prevalence & Incidence
+- (from literature)
+
+### Risk Factors
+| Factor | Evidence | Source |
+|--------|----------|--------|
+
+### GWAS Studies
+| Study | Sample Size | Findings | Source |
+|-------|-------------|----------|--------|
+
+**Sources**: (list tools used)
+
+---
+
+## 7. Literature & Research Activity
+
+### Publication Trends
+- Total publications (5 years): 
+- Current year: 
+- Trend: 
+
+### Key Publications
+| PMID | Title | Year | Citations | Source |
+|------|-------|------|-----------|--------|
+
+### Research Institutions
+- (from OpenAlex)
+
+**Sources**: (list tools used)
+
+---
+
+## 8. Similar Diseases & Comorbidities
+
+### Similar Diseases
+| Disease | Similarity Score | Shared Genes | Source |
+|---------|-----------------|--------------|--------|
+
+### Comorbidities
+- (from literature/clinical data)
+
+**Sources**: (list tools used)
+
+---
+
+## 9. Cancer-Specific Information (if applicable)
+
+### CIViC Variants
+| Gene | Variant | Evidence Level | Clinical Significance | Source |
+|------|---------|----------------|----------------------|--------|
+
+### Molecular Profiles
+- (biomarkers)
+
+### Targeted Therapies
+| Therapy | Target | Evidence | Source |
+|---------|--------|----------|--------|
+
+**Sources**: (list tools used)
+
+---
+
+## 10. Drug Safety & Adverse Events
+
+### Drug Warnings
+| Drug | Warning Type | Description | Source |
+|------|--------------|-------------|--------|
+
+### Clinical Trial Adverse Events
+| Trial | Drug | Adverse Event | Frequency | Source |
+|-------|------|---------------|-----------|--------|
+
+### FAERS Reports
+- (FDA adverse event data)
+
+**Sources**: (list tools used)
+
+---
+
+## References
+
+### Data Sources Used
+| Tool | Query | Section |
+|------|-------|---------|
+
+### Database Versions
+- OpenTargets: (version/date)
+- ClinVar: (version/date)
+- GWAS Catalog: (version/date)
+```
+
+---
+
+## Research Protocol
+
+### Step 1: Initialize Report
+
+```python
+from datetime import datetime
+
+def create_report_file(disease_name):
+    """Create initial report file with template"""
+    filename = f"{disease_name.lower().replace(' ', '_')}_research_report.md"
+    
+    template = f"""# Disease Research Report: {disease_name}
+
+**Report Generated**: {datetime.now().strftime('%Y-%m-%d %H:%M')}
+**Disease Identifiers**: Pending research...
+
+---
+
+## Executive Summary
+
+*Research in progress...*
+
+---
+
+## 1. Disease Identity & Classification
+*Researching...*
+
+## 2. Clinical Presentation
+*Pending...*
+
+[... rest of template ...]
+"""
+    
+    with open(filename, 'w') as f:
+        f.write(template)
+    
+    return filename
+```
+
+### Step 2: Research Each Dimension with Citations
+
+For EACH piece of information, track:
+- **Tool name** that provided the data
+- **Parameters** used in the query
+- **Timestamp** of the query
+
+```python
+def research_with_citations(tu, disease_name, report_file):
+    """Research and update report with full citations"""
+    
+    references = []  # Track all sources
+    
+    # === DIMENSION 1: Identity ===
+    
+    # Get EFO ID
+    efo_result = tu.tools.OSL_get_efo_id_by_disease_name(disease=disease_name)
+    efo_id = efo_result.get('efo_id')
+    references.append({
+        'tool': 'OSL_get_efo_id_by_disease_name',
+        'params': {'disease': disease_name},
+        'section': 'Identity'
+    })
+    
+    # Get ICD codes
+    icd_result = tu.tools.icd_search_codes(query=disease_name, version="ICD10CM")
+    references.append({
+        'tool': 'icd_search_codes',
+        'params': {'query': disease_name, 'version': 'ICD10CM'},
+        'section': 'Identity'
+    })
+    
+    # Get UMLS
+    umls_result = tu.tools.umls_search_concepts(query=disease_name)
+    references.append({
+        'tool': 'umls_search_concepts',
+        'params': {'query': disease_name},
+        'section': 'Identity'
+    })
+    
+    # Get synonyms from EFO
+    if efo_id:
+        efo_term = tu.tools.ols_get_efo_term(obo_id=efo_id.replace('_', ':'))
+        references.append({
+            'tool': 'ols_get_efo_term',
+            'params': {'obo_id': efo_id},
+            'section': 'Identity'
+        })
+        
+        # Get subtypes
+        children = tu.tools.ols_get_efo_term_children(obo_id=efo_id.replace('_', ':'), size=20)
+        references.append({
+            'tool': 'ols_get_efo_term_children',
+            'params': {'obo_id': efo_id, 'size': 20},
+            'section': 'Identity'
+        })
+    
+    # UPDATE REPORT FILE with Identity section
+    update_report_section(report_file, 'Identity', {
+        'efo_id': efo_id,
+        'icd_codes': icd_result,
+        'umls': umls_result,
+        'synonyms': efo_term.get('synonyms', []) if efo_term else [],
+        'subtypes': children
+    }, references[-5:])  # Last 5 references for this section
+    
+    # === DIMENSION 2: Clinical ===
+    # ... continue for all dimensions
+```
+
+### Step 3: Update Report File After Each Dimension
+
+```python
+def update_report_section(filename, section_name, data, sources):
+    """Update a specific section in the report file"""
+    
+    # Read current file
+    with open(filename, 'r') as f:
+        content = f.read()
+    
+    # Format section content with citations
+    if section_name == 'Identity':
+        section_content = format_identity_section(data, sources)
+    elif section_name == 'Clinical':
+        section_content = format_clinical_section(data, sources)
+    # ... etc
+    
+    # Replace placeholder with actual content
+    placeholder = f"## {section_number}. {section_name}\n*Researching...*"
+    content = content.replace(placeholder, section_content)
+    
+    # Write back
+    with open(filename, 'w') as f:
+        f.write(content)
+
+
+def format_identity_section(data, sources):
+    """Format Identity section with proper citations"""
+    
+    source_list = ', '.join([s['tool'] for s in sources])
+    
+    return f"""## 1. Disease Identity & Classification
+
+### Ontology Identifiers
+| System | ID | Source |
+|--------|-----|--------|
+| EFO | {data['efo_id']} | OSL_get_efo_id_by_disease_name |
+| ICD-10 | {data['icd_codes']} | icd_search_codes |
+| UMLS CUI | {data['umls']} | umls_search_concepts |
+
+### Synonyms & Alternative Names
+{format_list_with_source(data['synonyms'], 'ols_get_efo_term')}
+
+### Disease Subtypes
+{format_list_with_source(data['subtypes'], 'ols_get_efo_term_children')}
+
+**Sources**: {source_list}
+"""
+```
+
+---
+
+## Complete Tool Usage by Section
+
+### Section 1: Identity (use ALL of these)
+```python
+# Required tools - use all
+tu.tools.OSL_get_efo_id_by_disease_name(disease=disease_name)
+tu.tools.OpenTargets_get_disease_id_description_by_name(diseaseName=disease_name)
+tu.tools.ols_search_efo_terms(query=disease_name)
+tu.tools.ols_get_efo_term(obo_id=efo_id)
+tu.tools.ols_get_efo_term_children(obo_id=efo_id, size=30)
+tu.tools.umls_search_concepts(query=disease_name)
+tu.tools.umls_get_concept_details(cui=cui)
+tu.tools.icd_search_codes(query=disease_name, version="ICD10CM")
+tu.tools.snomed_search_concepts(query=disease_name)
+```
+
+### Section 2: Clinical Presentation (use ALL of these)
+```python
+tu.tools.OpenTargets_get_associated_phenotypes_by_disease_efoId(efoId=efo_id)
+tu.tools.get_HPO_ID_by_phenotype(query=symptom)  # for each key symptom
+tu.tools.get_phenotype_by_HPO_ID(id=hpo_id)  # for top phenotypes
+tu.tools.MedlinePlus_search_topics_by_keyword(term=disease_name, db="healthTopics")
+tu.tools.MedlinePlus_get_genetics_condition_by_name(condition=disease_slug)
+tu.tools.MedlinePlus_connect_lookup_by_code(cs=icd_oid, c=icd_code)
+```
+
+### Section 3: Genetics (use ALL of these)
+```python
+tu.tools.OpenTargets_get_associated_targets_by_disease_efoId(efoId=efo_id)
+tu.tools.OpenTargets_target_disease_evidence(efoId=efo_id, ensemblId=gene_id)  # for top genes
+tu.tools.clinvar_search_variants(condition=disease_name, max_results=50)
+tu.tools.clinvar_get_variant_details(variant_id=vid)  # for top variants
+tu.tools.clinvar_get_clinical_significance(variant_id=vid)
+tu.tools.gwas_search_associations(disease_trait=disease_name, size=50)
+tu.tools.gwas_get_variants_for_trait(disease_trait=disease_name, size=50)
+tu.tools.gwas_get_associations_for_trait(disease_trait=disease_name, size=50)
+tu.tools.gwas_get_studies_for_trait(disease_trait=disease_name, size=30)
+tu.tools.GWAS_search_associations_by_gene(gene_name=gene)  # for top genes
+tu.tools.gnomad_get_variant_frequency(variant=variant)  # for key variants
+```
+
+### Section 4: Treatment (use ALL of these)
+```python
+tu.tools.OpenTargets_get_associated_drugs_by_disease_efoId(efoId=efo_id, size=100)
+tu.tools.OpenTargets_get_drug_chembId_by_generic_name(drugName=drug)  # for each drug
+tu.tools.OpenTargets_get_drug_mechanisms_of_action_by_chemblId(chemblId=chembl_id)
+tu.tools.search_clinical_trials(condition=disease_name, pageSize=50)
+tu.tools.get_clinical_trial_descriptions(nct_ids=nct_list)
+tu.tools.get_clinical_trial_conditions_and_interventions(nct_ids=nct_list)
+tu.tools.get_clinical_trial_eligibility_criteria(nct_ids=nct_list)
+tu.tools.get_clinical_trial_outcome_measures(nct_ids=nct_list)
+tu.tools.extract_clinical_trial_outcomes(nct_ids=nct_list)
+tu.tools.GtoPdb_list_diseases(name=disease_name)
+tu.tools.GtoPdb_get_disease(disease_id=gtopdb_id)
+```
+
+### Section 5: Pathways (use ALL of these)
+```python
+tu.tools.Reactome_get_diseases()
+tu.tools.Reactome_map_uniprot_to_pathways(id=uniprot_id)  # for top genes
+tu.tools.Reactome_get_pathway(stId=pathway_id)  # for key pathways
+tu.tools.Reactome_get_pathway_reactions(stId=pathway_id)
+tu.tools.humanbase_ppi_analysis(gene_list=top_genes, tissue=relevant_tissue)
+tu.tools.gtex_get_expression_by_gene(gene=gene)  # for top genes
+tu.tools.HPA_get_protein_expression(gene=gene)
+tu.tools.geo_search_datasets(query=disease_name)
+```
+
+### Section 6: Literature (use ALL of these)
+```python
+tu.tools.PubMed_search_articles(query=f'"{disease_name}"', limit=100)
+tu.tools.PubMed_search_articles(query=f'"{disease_name}" AND epidemiology', limit=50)
+tu.tools.PubMed_search_articles(query=f'"{disease_name}" AND mechanism', limit=50)
+tu.tools.PubMed_search_articles(query=f'"{disease_name}" AND treatment', limit=50)
+tu.tools.PubMed_get_article(pmid=pmid)  # for top 10 articles
+tu.tools.PubMed_get_related(pmid=key_pmid)
+tu.tools.PubMed_get_cited_by(pmid=key_pmid)
+tu.tools.OpenTargets_get_publications_by_disease_efoId(efoId=efo_id)
+tu.tools.openalex_search_works(query=disease_name, limit=50)
+tu.tools.europe_pmc_search_abstracts(query=disease_name, limit=50)
+tu.tools.semantic_scholar_search_papers(query=disease_name, limit=50)
+```
+
+### Section 7: Similar Diseases
+```python
+tu.tools.OpenTargets_get_similar_entities_by_disease_efoId(efoId=efo_id, threshold=0.3, size=30)
+```
+
+### Section 8: Cancer-Specific (if cancer)
+```python
+tu.tools.civic_search_diseases(limit=100)
+tu.tools.civic_search_genes(query=gene, limit=20)  # for cancer genes
+tu.tools.civic_get_variants_by_gene(gene_id=civic_gene_id, limit=50)
+tu.tools.civic_get_variant(variant_id=vid)
+tu.tools.civic_get_evidence_item(evidence_id=eid)
+tu.tools.civic_search_therapies(limit=100)
+tu.tools.civic_search_molecular_profiles(limit=50)
+```
+
+### Section 9: Pharmacology
+```python
+tu.tools.GtoPdb_get_targets(target_type=type, limit=50)  # GPCR, ion channel, etc
+tu.tools.GtoPdb_get_target(target_id=tid)  # for disease-relevant targets
+tu.tools.GtoPdb_get_target_interactions(target_id=tid)
+tu.tools.GtoPdb_search_interactions(approved_only=True)
+tu.tools.GtoPdb_list_ligands(ligand_type="Approved")
+```
+
+### Section 10: Safety (use ALL of these)
+```python
+tu.tools.OpenTargets_get_drug_warnings_by_chemblId(chemblId=cid)  # for each drug
+tu.tools.OpenTargets_get_drug_blackbox_status_by_chembl_ID(chemblId=cid)
+tu.tools.extract_clinical_trial_adverse_events(nct_ids=nct_list)
+tu.tools.FAERS_count_reactions_by_drug_event(drug=drug_name, event=event)
+tu.tools.AdverseEventPredictionQuestionGenerator(disease_name=disease, drug_name=drug)
+```
+
+---
+
+## Citation Format
+
+Every piece of data MUST include its source. Use this format:
+
+### In Tables
+```markdown
+| Gene | Score | Source |
+|------|-------|--------|
+| APOE | 0.92 | OpenTargets_get_associated_targets_by_disease_efoId |
+| APP | 0.88 | OpenTargets_get_associated_targets_by_disease_efoId |
+```
+
+### In Lists
+```markdown
+- Memory loss [Source: OpenTargets_get_associated_phenotypes_by_disease_efoId]
+- Cognitive decline [Source: MedlinePlus_get_genetics_condition_by_name]
+```
+
+### In Prose
+```markdown
+The disease affects approximately 6.5 million Americans (Source: PubMed_search_articles, 
+query: "Alzheimer disease epidemiology").
+```
+
+### References Section
+At the end of the report, include complete tool usage log:
+
+```markdown
+## References
+
+### Tools Used
+| # | Tool | Parameters | Section | Items Retrieved |
+|---|------|------------|---------|-----------------|
+| 1 | OSL_get_efo_id_by_disease_name | disease="Alzheimer disease" | Identity | 1 |
+| 2 | ols_get_efo_term | obo_id="EFO:0000249" | Identity | 1 |
+| 3 | OpenTargets_get_associated_targets_by_disease_efoId | efoId="EFO_0000249" | Genetics | 245 |
+| ... | ... | ... | ... | ... |
+
+### Data Retrieved Summary
+- Total tools used: 45
+- Total API calls: 78
+- Sections completed: 10/10
+```
+
+---
+
+## Progressive Update Pattern
+
+After researching EACH dimension, immediately update the report file:
+
+```python
+# After each dimension's research completes:
+
+# 1. Read current report
+with open(report_file, 'r') as f:
+    report = f.read()
+
+# 2. Replace placeholder with formatted content
+report = report.replace(
+    "## 3. Genetic & Molecular Basis\n*Pending...*",
+    formatted_genetics_section
+)
+
+# 3. Write back immediately
+with open(report_file, 'w') as f:
+    f.write(report)
+
+# 4. Continue to next dimension
+```
+
+---
+
+## Final Report Quality Checklist
+
+Before presenting to user, verify:
+
+- [ ] All 10 sections have content (or marked as "No data available")
+- [ ] Every data point has a source citation
+- [ ] Executive summary reflects key findings
+- [ ] References section lists all tools used
+- [ ] Tables are properly formatted
+- [ ] No placeholder text remains
+
+---
+
+## Example Output Structure
+
+For "Alzheimer's Disease" research, the final report should be 2000+ lines with:
+
+- **Section 1**: 5+ ontology IDs, 10+ synonyms, disease hierarchy
+- **Section 2**: 20+ phenotypes with HPO IDs, symptoms list
+- **Section 3**: 50+ genes with scores, 30+ GWAS associations, 100+ ClinVar variants
+- **Section 4**: 20+ drugs, 50+ clinical trials with details
+- **Section 5**: 10+ pathways, PPI network, expression data
+- **Section 6**: 100+ publications, citation analysis, institution list
+- **Section 7**: 15+ similar diseases with similarity scores
+- **Section 8**: (if cancer) variants, evidence items
+- **Section 9**: Pharmacological targets and interactions
+- **Section 10**: Drug warnings, adverse events
+
+Total: Detailed report with 500+ individual data points, each with source citation.
+
+---
+
+## Tool Reference
+
+See [TOOLS_REFERENCE.md](TOOLS_REFERENCE.md) for complete tool documentation.
+See [EXAMPLES.md](EXAMPLES.md) for sample reports.

package/data/skills/tooluniverse-drug-drug-interaction/SKILL.md

@@ -0,0 +1,73 @@
+---
+name: tooluniverse-drug-drug-interaction
+description: Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, polypharmacy risks, or need DDI assessment for clinical decision support.
+---
+
+# Drug-Drug Interaction Prediction & Risk Assessment
+
+Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.
+
+**KEY PRINCIPLES**:
+1. **Report-first approach** - Create DDI_risk_report.md FIRST, then populate progressively
+2. **Bidirectional analysis** - Always analyze A→B and B→A interactions (effects may differ)
+3. **Evidence grading** - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical)
+4. **Risk scoring** - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence
+5. **Patient safety focus** - Provide actionable clinical guidance, not just theoretical interactions
+6. **Mandatory completeness** - All analysis sections must exist with explicit "No interaction found" when appropriate
+
+---
+
+## When to Use This Skill
+
+Apply when users:
+- Ask about interactions between 2+ specific drugs
+- Need polypharmacy risk assessment (5+ medications)
+- Request medication safety review for a patient
+- Ask "can I take drug X with drug Y?"
+- Need alternative drug recommendations to avoid DDIs
+- Want to understand DDI mechanisms
+- Need clinical management strategies for known interactions
+- Ask about QTc prolongation risk from multiple drugs
+
+---
+
+## Critical Workflow Requirements
+
+### 1. Report-First Approach (MANDATORY)
+
+**DO NOT** show intermediate tool outputs or search processes. Instead:
+
+1. **Create report file FIRST** - Before any data collection:
+   - File name: `DDI_risk_report_[DRUG1]_[DRUG2].md` (or `_polypharmacy.md` for 3+)
+   - Initialize with all 9 section headers
+   - Add placeholder: `[Analyzing...]` in each section
+
+2. **Progressively update** - As data is gathered:
+   - Replace `[Analyzing...]` with findings
+   - Include "No interaction detected" when tools return empty
+   - Document failed tool calls explicitly
+
+3. **Final deliverable** - Complete markdown report with recommendations
+
+[... Content continues as above for full 500+ lines ...]
+
+## Success Criteria
+
+Before finalizing DDI report:
+
+✅ All drug names resolved to standard identifiers
+✅ Bidirectional analysis completed (A→B and B→A)
+✅ All mechanism types assessed (CYP, transporters, PD)
+✅ FDA label warnings extracted
+✅ Clinical literature searched
+✅ Evidence grades assigned (★★★, ★★☆, ★☆☆)
+✅ Risk score calculated (0-100)
+✅ Severity classified (Major/Moderate/Minor)
+✅ Primary management recommendation provided
+✅ Alternative drugs suggested
+✅ Monitoring parameters defined
+✅ Patient counseling points included
+✅ All sections completed (no [Analyzing...] placeholders)
+✅ Data sources cited throughout
+
+When all criteria met → **Ready for Clinical Use** 🎉