finishm 0.0.8 → 0.0.9

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Files changed (41) hide show
  1. checksums.yaml +4 -4
  2. data/Rakefile +2 -1
  3. data/VERSION +1 -1
  4. data/bin/finishm +18 -18
  5. data/ext/mkrf_conf.rb +1 -1
  6. data/finishm.gemspec +23 -19
  7. data/lib/finishm/connect.rb +65 -0
  8. data/lib/priner.rb +3 -3
  9. data/spec/data/gapfilling/5/a.svg +1118 -0
  10. data/spec/data/gapfilling/5/reads.faVanswer.bam +0 -0
  11. data/spec/data/gapfilling/5/reads.faVanswer.bam.bai +0 -0
  12. data/spec/data/gapfilling/5/reads2.fa +17961 -0
  13. data/spec/data/gapfilling/5/to_gapfill.fa +2 -0
  14. data/spec/data/gapfilling/5/velvet23_3.5/Graph2 +8758 -0
  15. data/spec/data/gapfilling/5/velvet23_3.5/LastGraph +8337 -0
  16. data/spec/data/gapfilling/5/velvet23_3.5/Log +210 -0
  17. data/spec/data/gapfilling/5/velvet23_3.5/PreGraph +303 -0
  18. data/spec/data/gapfilling/5/velvet23_3.5/Roadmaps +20440 -0
  19. data/spec/data/gapfilling/5/velvet23_3.5/Sequences +20921 -0
  20. data/spec/data/gapfilling/5/velvet23_3.5/contigs.fa +296 -0
  21. data/spec/data/gapfilling/5/velvet23_3.5/stats.txt +100 -0
  22. data/spec/data/visualise/2_paired_end/a.svg +59 -0
  23. data/spec/data/wander/1/reference.broken.fa +4 -0
  24. data/spec/data/wander/1/reference.fa +2 -0
  25. data/spec/data/wander/1/reference_reads.fa +2004 -0
  26. metadata +23 -20
  27. data/ext/src/third-party/zlib-1.2.3/adler32.o +0 -0
  28. data/ext/src/third-party/zlib-1.2.3/compress.o +0 -0
  29. data/ext/src/third-party/zlib-1.2.3/crc32.o +0 -0
  30. data/ext/src/third-party/zlib-1.2.3/deflate.o +0 -0
  31. data/ext/src/third-party/zlib-1.2.3/example +0 -0
  32. data/ext/src/third-party/zlib-1.2.3/gzio.o +0 -0
  33. data/ext/src/third-party/zlib-1.2.3/infback.o +0 -0
  34. data/ext/src/third-party/zlib-1.2.3/inffast.o +0 -0
  35. data/ext/src/third-party/zlib-1.2.3/inflate.o +0 -0
  36. data/ext/src/third-party/zlib-1.2.3/inftrees.o +0 -0
  37. data/ext/src/third-party/zlib-1.2.3/libz.a +0 -0
  38. data/ext/src/third-party/zlib-1.2.3/minigzip +0 -0
  39. data/ext/src/third-party/zlib-1.2.3/trees.o +0 -0
  40. data/ext/src/third-party/zlib-1.2.3/uncompr.o +0 -0
  41. data/ext/src/third-party/zlib-1.2.3/zutil.o +0 -0
checksums.yaml CHANGED
@@ -1,7 +1,7 @@
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+ metadata.gz: 667e8e59b39401f9da3d1e8d8fc20e54edf4c8a2
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+ data.tar.gz: d233480875faa70a9d4c1b1fc0cf13cbec848af676c3b5005d5c0bc9230d0287cbda14859337c898065805ad9a59ee5b05d0722ccba5fa9fe8c59cc407d9219b
data/Rakefile CHANGED
@@ -16,7 +16,8 @@ Jeweler::Tasks.new do |gem|
16
16
  # gem is a Gem::Specification... see http://docs.rubygems.org/read/chapter/20 for more options
17
17
  gem.name = "finishm"
18
18
  gem.homepage = "http://github.com/wwood/finishm"
19
- gem.license = "GPL3+"
19
+ gem.license = "GPL-3.0+"
20
+ gem.required_ruby_version = '~> 2.3'
20
21
  gem.summary = %Q{Genome improvement and finishing with or without further sequencing effort}
21
22
  gem.description = %Q{De-novo assemblies generally only provide draft genomes. FinishM is aimed at improving these draft assemblies.}
22
23
  gem.email = "donttrustben near gmail.com"
data/VERSION CHANGED
@@ -1 +1 @@
1
- 0.0.8
1
+ 0.0.9
@@ -28,13 +28,13 @@ global = OptionParser.new do |opts|
28
28
  wander\tTry to connect contigs (experimental)
29
29
  gapfill\tFill assembly gaps (N characters) (experimental)
30
30
  explore\tWhat happens in the graph beyond the end of my contig(s)? (experimental)
31
+ "+ # primer stuff is not really ready and requires bio-primer3 to be released.
32
+ # Commands for PCR finishing:
31
33
 
32
- Commands for PCR finishing:
33
-
34
- primers\tdesign primers for multi-primer multi-lane PCR experimental setup (experimental)
35
- primers_check\ttest a set of primers for incompatibility (experimental)
36
- finish\tprocess results from multi-primer multi-lane PCR experimental setup (experimental)
37
-
34
+ # primers\tdesign primers for multi-primer multi-lane PCR experimental setup (experimental)
35
+ # primers_check\ttest a set of primers for incompatibility (experimental)
36
+ # finish\tprocess results from multi-primer multi-lane PCR experimental setup (experimental)
37
+ "
38
38
  Utility modes:
39
39
 
40
40
  sequence\tGiven a defined sequence of nodes, what is the corresponding sequence?
@@ -46,18 +46,18 @@ global.order!
46
46
 
47
47
  operator = nil
48
48
  subcommands = {
49
- 'primers' => lambda {OptionParser.new do |opts|
50
- operator = Bio::FinishM::Primers.new
51
- operator.add_options(opts, options)
52
- end},
53
- 'primers_check' => lambda {OptionParser.new do |opts|
54
- operator = Bio::FinishM::Primers::Checker.new
55
- operator.add_options(opts, options)
56
- end},
57
- 'finish' => lambda {OptionParser.new do |opts|
58
- operator = Bio::FinishM::Finisher.new
59
- operator.add_options(opts, options)
60
- end},
49
+ # 'primers' => lambda {OptionParser.new do |opts|
50
+ # operator = Bio::FinishM::Primers.new
51
+ # operator.add_options(opts, options)
52
+ # end},
53
+ # 'primers_check' => lambda {OptionParser.new do |opts|
54
+ # operator = Bio::FinishM::Primers::Checker.new
55
+ # operator.add_options(opts, options)
56
+ # end},
57
+ # 'finish' => lambda {OptionParser.new do |opts|
58
+ # operator = Bio::FinishM::Finisher.new
59
+ # operator.add_options(opts, options)
60
+ # end},
61
61
  'gapfill' => lambda {OptionParser.new do |opts|
62
62
  operator = Bio::FinishM::GapFiller.new
63
63
  operator.add_options(opts, options)
@@ -25,7 +25,7 @@ path_external = File.join(File.dirname(__FILE__), "../lib/external")
25
25
  task :compile do
26
26
  cd(File.join(File.dirname(__FILE__),'src')) do
27
27
  #sh "patch -p1 < ../bioruby.patch"
28
- case Config::CONFIG['host_os']
28
+ case RbConfig::CONFIG['host_os']
29
29
  when /linux/
30
30
 
31
31
  # Create library with default install params
@@ -2,17 +2,17 @@
2
2
  # DO NOT EDIT THIS FILE DIRECTLY
3
3
  # Instead, edit Jeweler::Tasks in Rakefile, and run 'rake gemspec'
4
4
  # -*- encoding: utf-8 -*-
5
- # stub: finishm 0.0.8 ruby lib
5
+ # stub: finishm 0.0.9 ruby lib
6
6
  # stub: ext/mkrf_conf.rb
7
7
 
8
8
  Gem::Specification.new do |s|
9
9
  s.name = "finishm"
10
- s.version = "0.0.8"
10
+ s.version = "0.0.9"
11
11
 
12
12
  s.required_rubygems_version = Gem::Requirement.new(">= 0") if s.respond_to? :required_rubygems_version=
13
13
  s.require_paths = ["lib"]
14
14
  s.authors = ["Ben J. Woodcroft"]
15
- s.date = "2016-08-01"
15
+ s.date = "2016-08-21"
16
16
  s.description = "De-novo assemblies generally only provide draft genomes. FinishM is aimed at improving these draft assemblies."
17
17
  s.email = "donttrustben near gmail.com"
18
18
  s.executables = ["finishm"]
@@ -111,7 +111,6 @@ Gem::Specification.new do |s|
111
111
  "ext/src/third-party/zlib-1.2.3/Makefile.in",
112
112
  "ext/src/third-party/zlib-1.2.3/README",
113
113
  "ext/src/third-party/zlib-1.2.3/adler32.c",
114
- "ext/src/third-party/zlib-1.2.3/adler32.o",
115
114
  "ext/src/third-party/zlib-1.2.3/algorithm.txt",
116
115
  "ext/src/third-party/zlib-1.2.3/amiga/Makefile.pup",
117
116
  "ext/src/third-party/zlib-1.2.3/amiga/Makefile.sas",
@@ -120,7 +119,6 @@ Gem::Specification.new do |s|
120
119
  "ext/src/third-party/zlib-1.2.3/as400/readme.txt",
121
120
  "ext/src/third-party/zlib-1.2.3/as400/zlib.inc",
122
121
  "ext/src/third-party/zlib-1.2.3/compress.c",
123
- "ext/src/third-party/zlib-1.2.3/compress.o",
124
122
  "ext/src/third-party/zlib-1.2.3/configure",
125
123
  "ext/src/third-party/zlib-1.2.3/contrib/README.contrib",
126
124
  "ext/src/third-party/zlib-1.2.3/contrib/ada/buffer_demo.adb",
@@ -248,11 +246,8 @@ Gem::Specification.new do |s|
248
246
  "ext/src/third-party/zlib-1.2.3/contrib/vstudio/vc8/zlibvc.vcproj",
249
247
  "ext/src/third-party/zlib-1.2.3/crc32.c",
250
248
  "ext/src/third-party/zlib-1.2.3/crc32.h",
251
- "ext/src/third-party/zlib-1.2.3/crc32.o",
252
249
  "ext/src/third-party/zlib-1.2.3/deflate.c",
253
250
  "ext/src/third-party/zlib-1.2.3/deflate.h",
254
- "ext/src/third-party/zlib-1.2.3/deflate.o",
255
- "ext/src/third-party/zlib-1.2.3/example",
256
251
  "ext/src/third-party/zlib-1.2.3/example.c",
257
252
  "ext/src/third-party/zlib-1.2.3/examples/README.examples",
258
253
  "ext/src/third-party/zlib-1.2.3/examples/fitblk.c",
@@ -265,22 +260,15 @@ Gem::Specification.new do |s|
265
260
  "ext/src/third-party/zlib-1.2.3/examples/zpipe.c",
266
261
  "ext/src/third-party/zlib-1.2.3/examples/zran.c",
267
262
  "ext/src/third-party/zlib-1.2.3/gzio.c",
268
- "ext/src/third-party/zlib-1.2.3/gzio.o",
269
263
  "ext/src/third-party/zlib-1.2.3/infback.c",
270
- "ext/src/third-party/zlib-1.2.3/infback.o",
271
264
  "ext/src/third-party/zlib-1.2.3/inffast.c",
272
265
  "ext/src/third-party/zlib-1.2.3/inffast.h",
273
- "ext/src/third-party/zlib-1.2.3/inffast.o",
274
266
  "ext/src/third-party/zlib-1.2.3/inffixed.h",
275
267
  "ext/src/third-party/zlib-1.2.3/inflate.c",
276
268
  "ext/src/third-party/zlib-1.2.3/inflate.h",
277
- "ext/src/third-party/zlib-1.2.3/inflate.o",
278
269
  "ext/src/third-party/zlib-1.2.3/inftrees.c",
279
270
  "ext/src/third-party/zlib-1.2.3/inftrees.h",
280
- "ext/src/third-party/zlib-1.2.3/inftrees.o",
281
- "ext/src/third-party/zlib-1.2.3/libz.a",
282
271
  "ext/src/third-party/zlib-1.2.3/make_vms.com",
283
- "ext/src/third-party/zlib-1.2.3/minigzip",
284
272
  "ext/src/third-party/zlib-1.2.3/minigzip.c",
285
273
  "ext/src/third-party/zlib-1.2.3/msdos/Makefile.bor",
286
274
  "ext/src/third-party/zlib-1.2.3/msdos/Makefile.dj2",
@@ -303,9 +291,7 @@ Gem::Specification.new do |s|
303
291
  "ext/src/third-party/zlib-1.2.3/qnx/package.qpg",
304
292
  "ext/src/third-party/zlib-1.2.3/trees.c",
305
293
  "ext/src/third-party/zlib-1.2.3/trees.h",
306
- "ext/src/third-party/zlib-1.2.3/trees.o",
307
294
  "ext/src/third-party/zlib-1.2.3/uncompr.c",
308
- "ext/src/third-party/zlib-1.2.3/uncompr.o",
309
295
  "ext/src/third-party/zlib-1.2.3/win32/DLL_FAQ.txt",
310
296
  "ext/src/third-party/zlib-1.2.3/win32/Makefile.bor",
311
297
  "ext/src/third-party/zlib-1.2.3/win32/Makefile.emx",
@@ -320,7 +306,6 @@ Gem::Specification.new do |s|
320
306
  "ext/src/third-party/zlib-1.2.3/zlib.h",
321
307
  "ext/src/third-party/zlib-1.2.3/zutil.c",
322
308
  "ext/src/third-party/zlib-1.2.3/zutil.h",
323
- "ext/src/third-party/zlib-1.2.3/zutil.o",
324
309
  "finishm.gemspec",
325
310
  "lib/assembly/a_b_visualiser.rb",
326
311
  "lib/assembly/acyclic_connection_finder.rb",
@@ -357,6 +342,7 @@ Gem::Specification.new do |s|
357
342
  "lib/assembly/velvet_graph_sequence_extractor.rb",
358
343
  "lib/external/VERSION",
359
344
  "lib/finishm/assemble.rb",
345
+ "lib/finishm/connect.rb",
360
346
  "lib/finishm/explore.rb",
361
347
  "lib/finishm/finisher.rb",
362
348
  "lib/finishm/fluff.rb",
@@ -456,9 +442,22 @@ Gem::Specification.new do |s|
456
442
  "spec/data/gapfilling/4/HOWTO_recreate",
457
443
  "spec/data/gapfilling/4/reads.fa.gz",
458
444
  "spec/data/gapfilling/5/HOWTO_RECREATE",
445
+ "spec/data/gapfilling/5/a.svg",
459
446
  "spec/data/gapfilling/5/answer.fna",
460
447
  "spec/data/gapfilling/5/gappy.fna",
461
448
  "spec/data/gapfilling/5/reads.fa",
449
+ "spec/data/gapfilling/5/reads.faVanswer.bam",
450
+ "spec/data/gapfilling/5/reads.faVanswer.bam.bai",
451
+ "spec/data/gapfilling/5/reads2.fa",
452
+ "spec/data/gapfilling/5/to_gapfill.fa",
453
+ "spec/data/gapfilling/5/velvet23_3.5/Graph2",
454
+ "spec/data/gapfilling/5/velvet23_3.5/LastGraph",
455
+ "spec/data/gapfilling/5/velvet23_3.5/Log",
456
+ "spec/data/gapfilling/5/velvet23_3.5/PreGraph",
457
+ "spec/data/gapfilling/5/velvet23_3.5/Roadmaps",
458
+ "spec/data/gapfilling/5/velvet23_3.5/Sequences",
459
+ "spec/data/gapfilling/5/velvet23_3.5/contigs.fa",
460
+ "spec/data/gapfilling/5/velvet23_3.5/stats.txt",
462
461
  "spec/data/gapfilling/5/velvet51_3.5/LastGraph",
463
462
  "spec/data/gapfilling/5/velvet51_3.5/Sequences",
464
463
  "spec/data/gapfilling/6/random1.fa",
@@ -518,12 +517,16 @@ Gem::Specification.new do |s|
518
517
  "spec/data/velvet_test_trails_reverse/reads_reversed.fa",
519
518
  "spec/data/visualise/1/LastGraph",
520
519
  "spec/data/visualise/2_paired_end/HOWTO_RECREATE.txt",
520
+ "spec/data/visualise/2_paired_end/a.svg",
521
521
  "spec/data/visualise/2_paired_end/rand1.fa",
522
522
  "spec/data/visualise/2_paired_end/rand2.fa",
523
523
  "spec/data/visualise/2_paired_end/with_gaps.fa",
524
524
  "spec/data/visualise/2_paired_end/with_gaps.read_pairs.fa.gz",
525
525
  "spec/data/wander/1/random1.fa",
526
526
  "spec/data/wander/1/random1.sammy.fa",
527
+ "spec/data/wander/1/reference.broken.fa",
528
+ "spec/data/wander/1/reference.fa",
529
+ "spec/data/wander/1/reference_reads.fa",
527
530
  "spec/depth_first_search_spec.rb",
528
531
  "spec/dijkstra_spec.rb",
529
532
  "spec/explore_spec.rb",
@@ -558,7 +561,8 @@ Gem::Specification.new do |s|
558
561
  "validation/gapfill_simulate_perfect.rb"
559
562
  ]
560
563
  s.homepage = "http://github.com/wwood/finishm"
561
- s.licenses = ["GPL3+"]
564
+ s.licenses = ["GPL-3.0+"]
565
+ s.required_ruby_version = Gem::Requirement.new("~> 2.3")
562
566
  s.rubygems_version = "2.5.1"
563
567
  s.summary = "Genome improvement and finishing with or without further sequencing effort"
564
568
 
@@ -0,0 +1,65 @@
1
+ require 'tmpdir'
2
+
3
+ class Bio::FinishM::GapFiller
4
+ include Bio::FinishM::Logging
5
+
6
+ def add_options(optparse_object, options)
7
+ optparse_object.banner = "\nUsage: finishm distance --read-sets <set1.fasta>,<set2.fasta>[,<set3.fasta>...] <assembly-specification>
8
+
9
+ Takes two or more set of reads determines the minimum distance between in a de-Bruijn graph traversal.
10
+
11
+ example: finishm distance --read-sets gene1reads.fa,gene2reads.fa,gene3reads.fa --fastq-gz reads.1.fq.gz,reads.2.fq.gz
12
+ \n"
13
+
14
+ options.merge!({
15
+ :graph_search_leash_length => 20000,
16
+ })
17
+
18
+ optparse_object.separator "\nRequired arguments:\n\n"
19
+ optparse_object.on("--read-sets FILES", Array, "comma-separated list of fasta files containing read sets to connect [required]") do |arg|
20
+ options[:read_sets] = arg
21
+ end
22
+
23
+ optparse_object.separator "\nThere must be some definition of of how to do the assembly, or else a path to a previous assembly directory:\n\n"
24
+ Bio::FinishM::ReadInput.new.add_options(optparse_object, options)
25
+ Bio::FinishM::GraphGenerator.new.add_options optparse_object, options
26
+
27
+ optparse_object.separator "\nOptional graph search options:\n\n"
28
+ optparse_object.on("--leash-length NUM", Integer, "Don't explore too far in the graph, only this many base pairs and not (much) more [default: #{options[:graph_search_leash_length] }]") do |arg|
29
+ options[:graph_search_leash_length] = arg
30
+ end
31
+ end
32
+
33
+ def validate_options(options, argv)
34
+ #TODO: give a better description of the error that has occurred
35
+ #TODO: require reads options
36
+ if argv.length != 0
37
+ return "Dangling argument(s) found e.g. #{argv[0] }"
38
+ else
39
+ [
40
+ :read_sets,
41
+ ].each do |sym|
42
+ if options[sym].nil?
43
+ return "No option found to specify #{sym}"
44
+ end
45
+ end
46
+
47
+ #if return nil from here, options all were parsed successfully
48
+ return Bio::FinishM::ReadInput.new.validate_options(options, [])
49
+ end
50
+ end
51
+
52
+ def run(options, argv)
53
+ # read in fasta file of read sets
54
+
55
+ # create a finishm graph with each of the reads in the read sets as probes
56
+
57
+ # Determine which nodes contain the reads, and choose two reads from each detected node as examples
58
+
59
+ # Dijkstra out from each of the probe nodes, ignoring direction
60
+
61
+ # Detemine connections between readsets given the minimum distances
62
+
63
+ # Output connectivity information
64
+ end
65
+ end
@@ -51,9 +51,9 @@ require 'assembly/bubbly_assembler'
51
51
  require 'assembly/bad_format_writer'
52
52
  require 'assembly/height_finder'
53
53
 
54
- require 'finishm/primers'
55
- require 'finishm/primers_check'
56
- require 'finishm/finisher'
54
+ #require 'finishm/primers' # Do not require as bio-primer3 has not been released.
55
+ #require 'finishm/primers_check'
56
+ #require 'finishm/finisher'
57
57
  require 'finishm/gapfiller'
58
58
  require 'finishm/wander'
59
59
  require 'finishm/fluff'
@@ -0,0 +1,1118 @@
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+ <g id="node46" class="node"><title>46</title>
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+ <!-- 6 -->
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+ <g id="node6" class="node"><title>6</title>
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+ <text text-anchor="middle" x="2490.06" y="-1133.59" font-family="Times Roman,serif" font-size="14.00">n6_length6_coverage43</text>
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+ <!-- 43 -->
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+ <g id="node43" class="node"><title>43</title>
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+ <ellipse fill="none" stroke="black" cx="2954.99" cy="-1383.47" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="2954.99" y="-1379.87" font-family="Times Roman,serif" font-size="14.00">n43_length30_coverage45</text>
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+ <g id="node7" class="node"><title>7</title>
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+ <ellipse fill="none" stroke="black" cx="2188.71" cy="-1152.09" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="2188.71" y="-1148.49" font-family="Times Roman,serif" font-size="14.00">n7_length105_coverage27</text>
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+ <!-- 6&#45;&gt;7 -->
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+ <g id="edge22" class="edge"><title>6&#45;&gt;7</title>
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+ <path fill="none" stroke="black" d="M2367.92,-1143.23C2356.07,-1143.82 2343.97,-1144.42 2331.93,-1145.01"/>
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+ <polygon fill="black" stroke="black" points="2331.66,-1141.52 2321.85,-1145.51 2332.01,-1148.51 2331.66,-1141.52"/>
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+ <!-- 72 -->
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+ <g id="node72" class="node"><title>72</title>
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+ <ellipse fill="none" stroke="black" cx="2321.81" cy="-886.917" rx="147.992" ry="18.3848"/>
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+ <text text-anchor="middle" x="2321.81" y="-883.317" font-family="Times Roman,serif" font-size="14.00">n72_length105_coverage20</text>
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+ <!-- 6&#45;&gt;72 -->
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+ <g id="edge20" class="edge"><title>6&#45;&gt;72</title>
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+ <path fill="none" stroke="black" d="M2477.41,-1118.38C2446.15,-1071.89 2365.54,-951.971 2334.37,-905.606"/>
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+ <!-- 28 -->
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+ <g id="node28" class="node"><title>28</title>
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+ <ellipse fill="none" stroke="black" cx="2020.2" cy="-902.53" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="2020.2" y="-898.93" font-family="Times Roman,serif" font-size="14.00">n28_length57_coverage53</text>
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+ <!-- 7&#45;&gt;28 -->
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+ <g id="edge26" class="edge"><title>7&#45;&gt;28</title>
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+ <path fill="none" stroke="black" d="M2176.05,-1133.34C2144.74,-1086.97 2064,-967.399 2032.78,-921.165"/>
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+ </g>
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+ <!-- 8 -->
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+ <g id="node8" class="node"><title>8</title>
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+ <ellipse fill="none" stroke="black" cx="1846.76" cy="-656.432" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="1846.76" y="-652.832" font-family="Times Roman,serif" font-size="14.00">n8_length288_coverage25</text>
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+ <!-- 8&#45;&gt;28 -->
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+ <g id="edge28" class="edge"><title>8&#45;&gt;28</title>
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+ <path fill="none" stroke="black" d="M1859.79,-674.929C1890.12,-717.953 1965.49,-824.912 2001.05,-875.367"/>
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+ <polygon fill="black" stroke="black" points="1998.39,-877.66 2007.01,-883.818 2004.11,-873.628 1998.39,-877.66"/>
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+ <!-- 47 -->
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+ <g id="node47" class="node"><title>47</title>
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+ <ellipse fill="none" stroke="black" cx="1545.71" cy="-680.455" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="1545.71" y="-676.855" font-family="Times Roman,serif" font-size="14.00">n47_length75_coverage44</text>
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+ <!-- 8&#45;&gt;47 -->
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+ <g id="edge30" class="edge"><title>8&#45;&gt;47</title>
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+ <path fill="none" stroke="blue" d="M1725.61,-666.099C1709.65,-667.373 1693.22,-668.684 1677.09,-669.971"/>
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+ <polygon fill="blue" stroke="blue" points="1676.79,-666.484 1667.1,-670.768 1677.35,-673.462 1676.79,-666.484"/>
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+ <!-- 9 -->
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+ <g id="node9" class="node"><title>9</title>
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+ <ellipse fill="none" stroke="black" cx="8890.42" cy="-6870.79" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="8890.42" y="-6867.19" font-family="Times Roman,serif" font-size="14.00">n9_length237_coverage30</text>
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+ <!-- 40 -->
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+ <g id="node40" class="node"><title>40</title>
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+ <ellipse fill="none" stroke="black" cx="8859.4" cy="-6570.07" rx="147.992" ry="18.3848"/>
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+ <text text-anchor="middle" x="8859.4" y="-6566.47" font-family="Times Roman,serif" font-size="14.00">n40_length118_coverage49</text>
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+ <!-- 9&#45;&gt;40 -->
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+ <g id="edge32" class="edge"><title>9&#45;&gt;40</title>
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+ <path fill="none" stroke="black" d="M8888.48,-6851.98C8882.91,-6797.98 8866.91,-6642.87 8861.34,-6588.88"/>
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+ <!-- 10 -->
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+ <g id="node10" class="node"><title>10</title>
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+ <ellipse fill="none" stroke="black" cx="5527.75" cy="-2787.33" rx="147.992" ry="18.3848"/>
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+ <text text-anchor="middle" x="5527.75" y="-2783.73" font-family="Times Roman,serif" font-size="14.00">n10_length189_coverage25</text>
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+ <!-- 10&#45;&gt;2 -->
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+ <g id="edge8" class="edge"><title>10&#45;&gt;2</title>
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+ <path fill="none" stroke="black" d="M5566.34,-2805.27C5615.49,-2828.12 5700.41,-2867.58 5753.53,-2892.27"/>
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+ <polygon fill="black" stroke="black" points="5752.19,-2895.51 5762.74,-2896.55 5755.14,-2889.16 5752.19,-2895.51"/>
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+ <!-- 48 -->
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+ <g id="node48" class="node"><title>48</title>
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+ <ellipse fill="none" stroke="black" cx="5325.93" cy="-2563.98" rx="147.992" ry="18.3848"/>
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+ <text text-anchor="middle" x="5325.93" y="-2560.38" font-family="Times Roman,serif" font-size="14.00">n48_length135_coverage46</text>
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+ <!-- 10&#45;&gt;48 -->
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+ <g id="edge36" class="edge"><title>10&#45;&gt;48</title>
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+ <path fill="none" stroke="blue" d="M5510.89,-2768.68C5474.96,-2728.92 5390.78,-2635.76 5349.54,-2590.12"/>
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+ <polygon fill="blue" stroke="blue" points="5351.9,-2587.5 5342.6,-2582.43 5346.7,-2592.2 5351.9,-2587.5"/>
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+ <!-- 11 -->
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+ <g id="node11" class="node"><title>11</title>
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+ <ellipse fill="none" stroke="black" cx="8177.95" cy="-5423.64" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="8177.95" y="-5420.04" font-family="Times Roman,serif" font-size="14.00">n11_length96_coverage21</text>
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+ <!-- 49 -->
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+ <g id="node49" class="node"><title>49</title>
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+ <ellipse fill="none" stroke="black" cx="7897.96" cy="-5309.89" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="7897.96" y="-5306.29" font-family="Times Roman,serif" font-size="14.00">n49_length18_coverage59</text>
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+ <!-- 11&#45;&gt;49 -->
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+ <g id="edge38" class="edge"><title>11&#45;&gt;49</title>
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+ <path fill="none" stroke="black" d="M8134.51,-5405.99C8085.05,-5385.9 8004.26,-5353.07 7951.09,-5331.47"/>
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+ <!-- 12 -->
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+ <g id="node12" class="node"><title>12</title>
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+ <ellipse fill="none" stroke="black" cx="143" cy="-86.4827" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="143" y="-82.8827" font-family="Times Roman,serif" font-size="14.00">n12_length84_coverage15</text>
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+ <!-- 36 -->
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+ <g id="node36" class="node"><title>36</title>
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+ <ellipse fill="none" stroke="black" cx="296.57" cy="-334.53" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="296.57" y="-330.93" font-family="Times Roman,serif" font-size="14.00">n36_length99_coverage27</text>
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+ <!-- 12&#45;&gt;36 -->
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+ <g id="edge42" class="edge"><title>12&#45;&gt;36</title>
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+ <path fill="none" stroke="black" d="M154.543,-105.127C181.401,-148.508 248.185,-256.378 279.655,-307.209"/>
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+ <polygon fill="black" stroke="black" points="276.863,-309.348 285.103,-316.008 282.814,-305.663 276.863,-309.348"/>
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+ <!-- 79 -->
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+ <g id="node79" class="node"><title>79</title>
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+ <ellipse fill="none" stroke="black" cx="428.365" cy="-19.5" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="428.365" y="-15.9" font-family="Times Roman,serif" font-size="14.00">n79_length99_coverage24</text>
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+ <!-- 12&#45;&gt;79 -->
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+ <g id="edge44" class="edge"><title>12&#45;&gt;79</title>
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+ <path fill="none" stroke="black" d="M212.079,-70.268C253.55,-60.5337 306.445,-48.1178 349.545,-38.0012"/>
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+ <polygon fill="black" stroke="black" points="350.493,-41.3739 359.428,-35.6813 348.893,-34.5591 350.493,-41.3739"/>
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+ <!-- 13 -->
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+ <g id="node13" class="node"><title>13</title>
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+ <ellipse fill="none" stroke="black" cx="7837.48" cy="-5013.72" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="7837.48" y="-5010.12" font-family="Times Roman,serif" font-size="14.00">n13_length51_coverage26</text>
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+ <!-- 13&#45;&gt;45 -->
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+ <g id="edge46" class="edge"><title>13&#45;&gt;45</title>
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+ <path fill="none" stroke="black" d="M7790.35,-4996.18C7737.93,-4976.67 7653.73,-4945.33 7601.26,-4925.8"/>
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+ </g>
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+ <!-- 14 -->
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+ <g id="node14" class="node"><title>14</title>
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+ <ellipse fill="none" stroke="black" cx="6390.42" cy="-3462.33" rx="147.992" ry="18.3848"/>
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+ <text text-anchor="middle" x="6390.42" y="-3458.73" font-family="Times Roman,serif" font-size="14.00">n14_length148_coverage23</text>
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+ <!-- 51 -->
241
+ <g id="node51" class="node"><title>51</title>
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+ <ellipse fill="none" stroke="black" cx="6465.11" cy="-3753.82" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="6465.11" y="-3750.22" font-family="Times Roman,serif" font-size="14.00">n51_length24_coverage45</text>
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+ <!-- 14&#45;&gt;51 -->
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+ <g id="edge50" class="edge"><title>14&#45;&gt;51</title>
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+ <path fill="none" stroke="black" d="M6395.21,-3481.01C6408.7,-3533.66 6446.92,-3682.84 6460.37,-3735.3"/>
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+ <!-- 14&#45;&gt;99 -->
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+ <g id="edge52" class="edge"><title>14&#45;&gt;99</title>
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+ <path fill="none" stroke="blue" d="M6338.2,-3444.93C6289.53,-3428.71 6216.91,-3404.51 6165.44,-3387.36"/>
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+ <!-- 15 -->
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+ <g id="node15" class="node"><title>15</title>
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+ <ellipse fill="none" stroke="black" cx="3717.59" cy="-1640.31" rx="147.992" ry="18.3848"/>
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+ <text text-anchor="middle" x="3717.59" y="-1636.71" font-family="Times Roman,serif" font-size="14.00">n15_length267_coverage25</text>
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+ <!-- 16 -->
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+ <g id="node16" class="node"><title>16</title>
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+ <ellipse fill="none" stroke="black" cx="3415.97" cy="-1638.6" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="3415.97" y="-1635" font-family="Times Roman,serif" font-size="14.00">n16_length23_coverage44</text>
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+ <!-- 15&#45;&gt;16 -->
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+ <g id="edge54" class="edge"><title>15&#45;&gt;16</title>
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+ <path fill="none" stroke="black" d="M3569.43,-1639.47C3569.08,-1639.47 3568.73,-1639.46 3568.38,-1639.46"/>
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+ <!-- 55 -->
270
+ <g id="node55" class="node"><title>55</title>
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+ <ellipse fill="none" stroke="black" cx="3874.99" cy="-1898.62" rx="142.128" ry="18.3848"/>
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+ <text text-anchor="middle" x="3874.99" y="-1895.02" font-family="Times Roman,serif" font-size="14.00">n55_length69_coverage45</text>
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+ <!-- 15&#45;&gt;55 -->
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+ <g id="edge56" class="edge"><title>15&#45;&gt;55</title>
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+ <path fill="none" stroke="blue" d="M3728.91,-1658.89C3756.24,-1703.74 3825.94,-1818.14 3858.18,-1871.03"/>
277
+ <polygon fill="blue" stroke="blue" points="3855.37,-1873.15 3863.56,-1879.87 3861.34,-1869.51 3855.37,-1873.15"/>
278
+ </g>
279
+ <!-- 17 -->
280
+ <g id="node17" class="node"><title>17</title>
281
+ <ellipse fill="none" stroke="black" cx="3256.74" cy="-1381.66" rx="142.128" ry="18.3848"/>
282
+ <text text-anchor="middle" x="3256.74" y="-1378.06" font-family="Times Roman,serif" font-size="14.00">n17_length91_coverage22</text>
283
+ </g>
284
+ <!-- 16&#45;&gt;17 -->
285
+ <g id="edge60" class="edge"><title>16&#45;&gt;17</title>
286
+ <path fill="none" stroke="black" d="M3404.52,-1620.12C3376.87,-1575.51 3306.36,-1461.72 3273.75,-1409.11"/>
287
+ <polygon fill="black" stroke="black" points="3276.55,-1406.97 3268.31,-1400.32 3270.6,-1410.66 3276.55,-1406.97"/>
288
+ </g>
289
+ <!-- 62 -->
290
+ <g id="node62" class="node"><title>62</title>
291
+ <ellipse fill="none" stroke="black" cx="3114.41" cy="-1639.95" rx="142.128" ry="18.3848"/>
292
+ <text text-anchor="middle" x="3114.41" y="-1636.35" font-family="Times Roman,serif" font-size="14.00">n62_length91_coverage26</text>
293
+ </g>
294
+ <!-- 16&#45;&gt;62 -->
295
+ <g id="edge58" class="edge"><title>16&#45;&gt;62</title>
296
+ <path fill="none" stroke="black" d="M3274.02,-1639.23C3268.22,-1639.26 3262.39,-1639.28 3256.59,-1639.31"/>
297
+ </g>
298
+ <!-- 17&#45;&gt;43 -->
299
+ <g id="edge64" class="edge"><title>17&#45;&gt;43</title>
300
+ <path fill="none" stroke="black" d="M3114.7,-1382.51C3108.9,-1382.55 3103.07,-1382.58 3097.26,-1382.62"/>
301
+ </g>
302
+ <!-- 18 -->
303
+ <g id="node18" class="node"><title>18</title>
304
+ <ellipse fill="none" stroke="black" cx="8273.32" cy="-6020.76" rx="142.128" ry="18.3848"/>
305
+ <text text-anchor="middle" x="8273.32" y="-6017.16" font-family="Times Roman,serif" font-size="14.00">n18_length96_coverage24</text>
306
+ </g>
307
+ <!-- 53 -->
308
+ <g id="node53" class="node"><title>53</title>
309
+ <ellipse fill="none" stroke="black" cx="8229.55" cy="-5721.65" rx="142.128" ry="18.3848"/>
310
+ <text text-anchor="middle" x="8229.55" y="-5718.05" font-family="Times Roman,serif" font-size="14.00">n53_length21_coverage47</text>
311
+ </g>
312
+ <!-- 18&#45;&gt;53 -->
313
+ <g id="edge68" class="edge"><title>18&#45;&gt;53</title>
314
+ <path fill="none" stroke="blue" d="M8270.58,-6002.05C8263.17,-5951.37 8242.65,-5811.21 8233.76,-5750.41"/>
315
+ <polygon fill="blue" stroke="blue" points="8237.19,-5749.74 8232.28,-5740.35 8230.27,-5750.76 8237.19,-5749.74"/>
316
+ </g>
317
+ <!-- 98 -->
318
+ <g id="node98" class="node"><title>98</title>
319
+ <ellipse fill="none" stroke="black" cx="8549.42" cy="-6142.34" rx="135.765" ry="18.3848"/>
320
+ <text text-anchor="middle" x="8549.42" y="-6138.74" font-family="Times Roman,serif" font-size="14.00">n98_length9_coverage52</text>
321
+ </g>
322
+ <!-- 18&#45;&gt;98 -->
323
+ <g id="edge66" class="edge"><title>18&#45;&gt;98</title>
324
+ <path fill="none" stroke="black" d="M8313.76,-6038.57C8366.04,-6061.59 8456.54,-6101.44 8508.87,-6124.48"/>
325
+ </g>
326
+ <!-- 19 -->
327
+ <g id="node19" class="node"><title>19</title>
328
+ <ellipse fill="none" stroke="black" cx="9188.32" cy="-7303.87" rx="142.128" ry="18.3848"/>
329
+ <text text-anchor="middle" x="9188.32" y="-7300.27" font-family="Times Roman,serif" font-size="14.00">n19_length51_coverage21</text>
330
+ </g>
331
+ <!-- 41 -->
332
+ <g id="node41" class="node"><title>41</title>
333
+ <ellipse fill="none" stroke="black" cx="9161.74" cy="-7002.93" rx="142.128" ry="18.3848"/>
334
+ <text text-anchor="middle" x="9161.74" y="-6999.33" font-family="Times Roman,serif" font-size="14.00">n41_length60_coverage53</text>
335
+ </g>
336
+ <!-- 19&#45;&gt;41 -->
337
+ <g id="edge72" class="edge"><title>19&#45;&gt;41</title>
338
+ <path fill="none" stroke="blue" d="M9186.66,-7285.04C9182.16,-7234.06 9169.7,-7093.04 9164.29,-7031.87"/>
339
+ <polygon fill="blue" stroke="blue" points="9167.77,-7031.4 9163.4,-7021.75 9160.79,-7032.02 9167.77,-7031.4"/>
340
+ </g>
341
+ <!-- 90 -->
342
+ <g id="node90" class="node"><title>90</title>
343
+ <ellipse fill="none" stroke="black" cx="9458.03" cy="-7439.64" rx="135.765" ry="18.3848"/>
344
+ <text text-anchor="middle" x="9458.03" y="-7436.04" font-family="Times Roman,serif" font-size="14.00">n90_length1_coverage54</text>
345
+ </g>
346
+ <!-- 19&#45;&gt;90 -->
347
+ <g id="edge70" class="edge"><title>19&#45;&gt;90</title>
348
+ <path fill="none" stroke="black" d="M9224.14,-7321.9C9275.87,-7347.94 9370.93,-7395.79 9422.5,-7421.75"/>
349
+ </g>
350
+ <!-- 20 -->
351
+ <g id="node20" class="node"><title>20</title>
352
+ <ellipse fill="none" stroke="black" cx="7485.14" cy="-4614.12" rx="147.992" ry="18.3848"/>
353
+ <text text-anchor="middle" x="7485.14" y="-4610.52" font-family="Times Roman,serif" font-size="14.00">n20_length204_coverage25</text>
354
+ </g>
355
+ <!-- 20&#45;&gt;45 -->
356
+ <g id="edge76" class="edge"><title>20&#45;&gt;45</title>
357
+ <path fill="none" stroke="blue" d="M7489.55,-4632.96C7501.29,-4683.07 7533.33,-4819.86 7547.33,-4879.63"/>
358
+ <polygon fill="blue" stroke="blue" points="7543.96,-4880.59 7549.65,-4889.53 7550.77,-4878.99 7543.96,-4880.59"/>
359
+ </g>
360
+ <!-- 20&#45;&gt;46 -->
361
+ <g id="edge74" class="edge"><title>20&#45;&gt;46</title>
362
+ <path fill="none" stroke="black" d="M7433.91,-4596.67C7381.75,-4578.91 7301.36,-4551.53 7249.36,-4533.82"/>
363
+ </g>
364
+ <!-- 21 -->
365
+ <g id="node21" class="node"><title>21</title>
366
+ <ellipse fill="none" stroke="black" cx="10978.9" cy="-10202" rx="135.765" ry="18.3848"/>
367
+ <text text-anchor="middle" x="10978.9" y="-10198.4" font-family="Times Roman,serif" font-size="14.00">n21_length4_coverage60</text>
368
+ </g>
369
+ <!-- 22 -->
370
+ <g id="node22" class="node"><title>22</title>
371
+ <ellipse fill="none" stroke="black" cx="10928.9" cy="-10500.1" rx="142.128" ry="18.3848"/>
372
+ <text text-anchor="middle" x="10928.9" y="-10496.5" font-family="Times Roman,serif" font-size="14.00">n22_length51_coverage31</text>
373
+ </g>
374
+ <!-- 21&#45;&gt;22 -->
375
+ <g id="edge78" class="edge"><title>21&#45;&gt;22</title>
376
+ <path fill="none" stroke="black" d="M10975.7,-10220.7C10967.3,-10271.2 10943.9,-10410.8 10933.7,-10471.4"/>
377
+ <polygon fill="black" stroke="black" points="10930.2,-10471 10932,-10481.5 10937.1,-10472.2 10930.2,-10471"/>
378
+ </g>
379
+ <!-- 35 -->
380
+ <g id="node35" class="node"><title>35</title>
381
+ <ellipse fill="none" stroke="black" cx="11014" cy="-9901.59" rx="147.992" ry="18.3848"/>
382
+ <text text-anchor="middle" x="11014" y="-9897.99" font-family="Times Roman,serif" font-size="14.00">n35_length101_coverage23</text>
383
+ </g>
384
+ <!-- 21&#45;&gt;35 -->
385
+ <g id="edge82" class="edge"><title>21&#45;&gt;35</title>
386
+ <path fill="none" stroke="blue" d="M10981.1,-10183.2C10987,-10132.3 11003.5,-9991.54 11010.6,-9930.47"/>
387
+ <polygon fill="blue" stroke="blue" points="11014.1,-9930.71 11011.8,-9920.37 11007.2,-9929.9 11014.1,-9930.71"/>
388
+ </g>
389
+ <!-- 77 -->
390
+ <g id="node77" class="node"><title>77</title>
391
+ <ellipse fill="none" stroke="black" cx="10741.7" cy="-10018.1" rx="147.992" ry="18.3848"/>
392
+ <text text-anchor="middle" x="10741.7" y="-10014.5" font-family="Times Roman,serif" font-size="14.00">n77_length101_coverage23</text>
393
+ </g>
394
+ <!-- 21&#45;&gt;77 -->
395
+ <g id="edge84" class="edge"><title>21&#45;&gt;77</title>
396
+ <path fill="none" stroke="blue" d="M10955.3,-10183.7C10912.4,-10150.5 10821.7,-10080.2 10773.5,-10042.8"/>
397
+ <polygon fill="blue" stroke="blue" points="10775.6,-10040 10765.5,-10036.6 10771.3,-10045.5 10775.6,-10040"/>
398
+ </g>
399
+ <!-- 92 -->
400
+ <g id="node92" class="node"><title>92</title>
401
+ <ellipse fill="none" stroke="black" cx="11208.5" cy="-10395.1" rx="142.128" ry="18.3848"/>
402
+ <text text-anchor="middle" x="11208.5" y="-10391.5" font-family="Times Roman,serif" font-size="14.00">n92_length51_coverage26</text>
403
+ </g>
404
+ <!-- 21&#45;&gt;92 -->
405
+ <g id="edge80" class="edge"><title>21&#45;&gt;92</title>
406
+ <path fill="none" stroke="black" d="M11000.9,-10220.5C11042.4,-10255.4 11132.1,-10330.9 11178.9,-10370.2"/>
407
+ <polygon fill="black" stroke="black" points="11176.6,-10372.9 11186.5,-10376.6 11181.1,-10367.5 11176.6,-10372.9"/>
408
+ </g>
409
+ <!-- 56 -->
410
+ <g id="node56" class="node"><title>56</title>
411
+ <ellipse fill="none" stroke="black" cx="11157.6" cy="-10693.2" rx="142.128" ry="18.3848"/>
412
+ <text text-anchor="middle" x="11157.6" y="-10689.6" font-family="Times Roman,serif" font-size="14.00">n56_length45_coverage44</text>
413
+ </g>
414
+ <!-- 22&#45;&gt;56 -->
415
+ <g id="edge86" class="edge"><title>22&#45;&gt;56</title>
416
+ <path fill="none" stroke="black" d="M10950.8,-10518.6C10992.1,-10553.4 11081.2,-10628.7 11127.8,-10668.1"/>
417
+ <polygon fill="black" stroke="black" points="11125.8,-10671 11135.7,-10674.8 11130.3,-10665.6 11125.8,-10671"/>
418
+ </g>
419
+ <!-- 23 -->
420
+ <g id="node23" class="node"><title>23</title>
421
+ <ellipse fill="none" stroke="black" cx="11226.5" cy="-11475" rx="147.992" ry="18.3848"/>
422
+ <text text-anchor="middle" x="11226.5" y="-11471.4" font-family="Times Roman,serif" font-size="14.00">n23_length174_coverage25</text>
423
+ </g>
424
+ <!-- 59 -->
425
+ <g id="node59" class="node"><title>59</title>
426
+ <ellipse fill="none" stroke="black" cx="11316.4" cy="-11187.1" rx="142.128" ry="18.3848"/>
427
+ <text text-anchor="middle" x="11316.4" y="-11183.5" font-family="Times Roman,serif" font-size="14.00">n59_length54_coverage46</text>
428
+ </g>
429
+ <!-- 23&#45;&gt;59 -->
430
+ <g id="edge88" class="edge"><title>23&#45;&gt;59</title>
431
+ <path fill="none" stroke="black" d="M11232.4,-11456.1C11248.7,-11403.8 11294.4,-11257.6 11310.6,-11205.7"/>
432
+ </g>
433
+ <!-- 24 -->
434
+ <g id="node24" class="node"><title>24</title>
435
+ <ellipse fill="none" stroke="black" cx="10293.2" cy="-9081.87" rx="147.992" ry="18.3848"/>
436
+ <text text-anchor="middle" x="10293.2" y="-9078.27" font-family="Times Roman,serif" font-size="14.00">n24_length126_coverage31</text>
437
+ </g>
438
+ <!-- 70 -->
439
+ <g id="node70" class="node"><title>70</title>
440
+ <ellipse fill="none" stroke="black" cx="10547.4" cy="-9243.88" rx="142.128" ry="18.3848"/>
441
+ <text text-anchor="middle" x="10547.4" y="-9240.28" font-family="Times Roman,serif" font-size="14.00">n70_length18_coverage45</text>
442
+ </g>
443
+ <!-- 24&#45;&gt;70 -->
444
+ <g id="edge92" class="edge"><title>24&#45;&gt;70</title>
445
+ <path fill="none" stroke="black" d="M10321.9,-9100.14C10370.8,-9131.34 10470,-9194.52 10518.8,-9225.68"/>
446
+ </g>
447
+ <!-- 25 -->
448
+ <g id="node25" class="node"><title>25</title>
449
+ <ellipse fill="none" stroke="black" cx="1245.77" cy="-712.399" rx="142.128" ry="18.3848"/>
450
+ <text text-anchor="middle" x="1245.77" y="-708.799" font-family="Times Roman,serif" font-size="14.00">n25_length75_coverage27</text>
451
+ </g>
452
+ <!-- 25&#45;&gt;47 -->
453
+ <g id="edge96" class="edge"><title>25&#45;&gt;47</title>
454
+ <path fill="none" stroke="black" d="M1355.75,-700.686C1381.84,-697.908 1409.66,-694.945 1435.74,-692.167"/>
455
+ </g>
456
+ <!-- 97 -->
457
+ <g id="node97" class="node"><title>97</title>
458
+ <ellipse fill="none" stroke="black" cx="1068.25" cy="-470.554" rx="135.765" ry="18.3848"/>
459
+ <text text-anchor="middle" x="1068.25" y="-466.954" font-family="Times Roman,serif" font-size="14.00">n97_length6_coverage65</text>
460
+ </g>
461
+ <!-- 25&#45;&gt;97 -->
462
+ <g id="edge98" class="edge"><title>25&#45;&gt;97</title>
463
+ <path fill="none" stroke="blue" d="M1232.13,-693.824C1200.96,-651.356 1124.38,-547.026 1088.03,-497.496"/>
464
+ <polygon fill="blue" stroke="blue" points="1090.67,-495.183 1081.93,-489.193 1085.03,-499.325 1090.67,-495.183"/>
465
+ </g>
466
+ <!-- 26 -->
467
+ <g id="node26" class="node"><title>26</title>
468
+ <ellipse fill="none" stroke="black" cx="11093.8" cy="-10988.2" rx="142.128" ry="18.3848"/>
469
+ <text text-anchor="middle" x="11093.8" y="-10984.6" font-family="Times Roman,serif" font-size="14.00">n26_length51_coverage26</text>
470
+ </g>
471
+ <!-- 26&#45;&gt;56 -->
472
+ <g id="edge100" class="edge"><title>26&#45;&gt;56</title>
473
+ <path fill="none" stroke="black" d="M11097.9,-10969.3C11109.4,-10916 11142,-10765 11153.5,-10712"/>
474
+ </g>
475
+ <!-- 26&#45;&gt;59 -->
476
+ <g id="edge102" class="edge"><title>26&#45;&gt;59</title>
477
+ <path fill="none" stroke="blue" d="M11114.4,-11006.5C11154.4,-11042.3 11242.8,-11121.3 11288.2,-11161.9"/>
478
+ <polygon fill="blue" stroke="blue" points="11286.1,-11164.7 11295.9,-11168.8 11290.8,-11159.5 11286.1,-11164.7"/>
479
+ </g>
480
+ <!-- 63 -->
481
+ <g id="node63" class="node"><title>63</title>
482
+ <ellipse fill="none" stroke="black" cx="1719.34" cy="-925.927" rx="147.992" ry="18.3848"/>
483
+ <text text-anchor="middle" x="1719.34" y="-922.327" font-family="Times Roman,serif" font-size="14.00">n63_length288_coverage27</text>
484
+ </g>
485
+ <!-- 28&#45;&gt;63 -->
486
+ <g id="edge108" class="edge"><title>28&#45;&gt;63</title>
487
+ <path fill="none" stroke="blue" d="M1898.26,-912.013C1884.23,-913.103 1869.87,-914.221 1855.67,-915.325"/>
488
+ <polygon fill="blue" stroke="blue" points="1855.06,-911.861 1845.37,-916.126 1855.61,-918.84 1855.06,-911.861"/>
489
+ </g>
490
+ <!-- 28&#45;&gt;72 -->
491
+ <g id="edge106" class="edge"><title>28&#45;&gt;72</title>
492
+ <path fill="none" stroke="black" d="M2152.49,-895.682C2159.89,-895.299 2167.35,-894.913 2174.79,-894.527"/>
493
+ <polygon fill="black" stroke="black" points="2175.13,-898.015 2184.94,-894.002 2174.77,-891.024 2175.13,-898.015"/>
494
+ </g>
495
+ <!-- 29 -->
496
+ <g id="node29" class="node"><title>29</title>
497
+ <ellipse fill="none" stroke="black" cx="10036.7" cy="-8627.87" rx="142.128" ry="18.3848"/>
498
+ <text text-anchor="middle" x="10036.7" y="-8624.27" font-family="Times Roman,serif" font-size="14.00">n29_length54_coverage25</text>
499
+ </g>
500
+ <!-- 52 -->
501
+ <g id="node52" class="node"><title>52</title>
502
+ <ellipse fill="none" stroke="black" cx="10297.2" cy="-8780.28" rx="142.128" ry="18.3848"/>
503
+ <text text-anchor="middle" x="10297.2" y="-8776.68" font-family="Times Roman,serif" font-size="14.00">n52_length36_coverage51</text>
504
+ </g>
505
+ <!-- 29&#45;&gt;52 -->
506
+ <g id="edge112" class="edge"><title>29&#45;&gt;52</title>
507
+ <path fill="none" stroke="blue" d="M10067.6,-8645.95C10115,-8673.68 10205.6,-8726.69 10257.7,-8757.17"/>
508
+ <polygon fill="blue" stroke="blue" points="10256,-8760.19 10266.4,-8762.22 10259.5,-8754.15 10256,-8760.19"/>
509
+ </g>
510
+ <!-- 60 -->
511
+ <g id="node60" class="node"><title>60</title>
512
+ <ellipse fill="none" stroke="black" cx="10029.2" cy="-8326.41" rx="142.128" ry="18.3848"/>
513
+ <text text-anchor="middle" x="10029.2" y="-8322.81" font-family="Times Roman,serif" font-size="14.00">n60_length18_coverage55</text>
514
+ </g>
515
+ <!-- 29&#45;&gt;60 -->
516
+ <g id="edge110" class="edge"><title>29&#45;&gt;60</title>
517
+ <path fill="none" stroke="black" d="M10036.2,-8609.01C10035,-8557.94 10031.4,-8416.68 10029.9,-8355.39"/>
518
+ <polygon fill="black" stroke="black" points="10033.4,-8355.17 10029.7,-8345.26 10026.4,-8355.34 10033.4,-8355.17"/>
519
+ </g>
520
+ <!-- 30 -->
521
+ <g id="node30" class="node"><title>30</title>
522
+ <ellipse fill="none" stroke="black" cx="8823.08" cy="-6269.77" rx="142.128" ry="18.3848"/>
523
+ <text text-anchor="middle" x="8823.08" y="-6266.17" font-family="Times Roman,serif" font-size="14.00">n30_length51_coverage27</text>
524
+ </g>
525
+ <!-- 30&#45;&gt;40 -->
526
+ <g id="edge114" class="edge"><title>30&#45;&gt;40</title>
527
+ <path fill="none" stroke="black" d="M8825.35,-6288.55C8831.51,-6339.43 8848.53,-6480.15 8855.91,-6541.2"/>
528
+ <polygon fill="black" stroke="black" points="8852.45,-6541.79 8857.13,-6551.3 8859.4,-6540.95 8852.45,-6541.79"/>
529
+ </g>
530
+ <!-- 30&#45;&gt;98 -->
531
+ <g id="edge116" class="edge"><title>30&#45;&gt;98</title>
532
+ <path fill="none" stroke="blue" d="M8784.74,-6251.91C8735.62,-6229.04 8650.47,-6189.39 8597.18,-6164.58"/>
533
+ <polygon fill="blue" stroke="blue" points="8598.49,-6161.33 8587.94,-6160.28 8595.53,-6167.67 8598.49,-6161.33"/>
534
+ </g>
535
+ <!-- 31 -->
536
+ <g id="node31" class="node"><title>31</title>
537
+ <ellipse fill="none" stroke="black" cx="4034.12" cy="-2156" rx="142.128" ry="18.3848"/>
538
+ <text text-anchor="middle" x="4034.12" y="-2152.4" font-family="Times Roman,serif" font-size="14.00">n31_length78_coverage30</text>
539
+ </g>
540
+ <!-- 85 -->
541
+ <g id="node85" class="node"><title>85</title>
542
+ <ellipse fill="none" stroke="black" cx="4335.63" cy="-2157.57" rx="142.128" ry="18.3848"/>
543
+ <text text-anchor="middle" x="4335.63" y="-2153.97" font-family="Times Roman,serif" font-size="14.00">n85_length36_coverage56</text>
544
+ </g>
545
+ <!-- 31&#45;&gt;85 -->
546
+ <g id="edge118" class="edge"><title>31&#45;&gt;85</title>
547
+ <path fill="none" stroke="black" d="M4176.04,-2156.74C4178.49,-2156.75 4180.94,-2156.76 4183.4,-2156.78"/>
548
+ <polygon fill="black" stroke="black" points="4183.46,-2160.28 4193.47,-2156.83 4183.49,-2153.28 4183.46,-2160.28"/>
549
+ </g>
550
+ <!-- 32 -->
551
+ <g id="node32" class="node"><title>32</title>
552
+ <ellipse fill="none" stroke="black" cx="10013.4" cy="-8024.97" rx="147.992" ry="18.3848"/>
553
+ <text text-anchor="middle" x="10013.4" y="-8021.37" font-family="Times Roman,serif" font-size="14.00">n32_length102_coverage28</text>
554
+ </g>
555
+ <!-- 95 -->
556
+ <g id="node95" class="node"><title>95</title>
557
+ <ellipse fill="none" stroke="black" cx="9748.04" cy="-7880.29" rx="135.765" ry="18.3848"/>
558
+ <text text-anchor="middle" x="9748.04" y="-7876.69" font-family="Times Roman,serif" font-size="14.00">n95_length2_coverage47</text>
559
+ </g>
560
+ <!-- 32&#45;&gt;95 -->
561
+ <g id="edge122" class="edge"><title>32&#45;&gt;95</title>
562
+ <path fill="none" stroke="black" d="M9980.09,-8006.79C9931.89,-7980.52 9842.77,-7931.94 9790.11,-7903.23"/>
563
+ <polygon fill="black" stroke="black" points="9791.49,-7900 9781.03,-7898.28 9788.14,-7906.14 9791.49,-7900"/>
564
+ </g>
565
+ <!-- 33 -->
566
+ <g id="node33" class="node"><title>33</title>
567
+ <ellipse fill="none" stroke="black" cx="6374" cy="-6256.5" rx="135.765" ry="18.3848"/>
568
+ <text text-anchor="middle" x="6374" y="-6252.9" font-family="Times Roman,serif" font-size="14.00">n33_length23_coverage5</text>
569
+ </g>
570
+ <!-- 34 -->
571
+ <g id="node34" class="node"><title>34</title>
572
+ <ellipse fill="none" stroke="black" cx="889.1" cy="-230.795" rx="147.992" ry="18.3848"/>
573
+ <text text-anchor="middle" x="889.1" y="-227.195" font-family="Times Roman,serif" font-size="14.00">n34_length129_coverage29</text>
574
+ </g>
575
+ <!-- 34&#45;&gt;97 -->
576
+ <g id="edge126" class="edge"><title>34&#45;&gt;97</title>
577
+ <path fill="none" stroke="black" d="M903.157,-249.608C936.647,-294.428 1020.83,-407.097 1054.26,-451.828"/>
578
+ </g>
579
+ <!-- 78 -->
580
+ <g id="node78" class="node"><title>78</title>
581
+ <ellipse fill="none" stroke="black" cx="10775.5" cy="-9718.02" rx="142.128" ry="18.3848"/>
582
+ <text text-anchor="middle" x="10775.5" y="-9714.42" font-family="Times Roman,serif" font-size="14.00">n78_length63_coverage47</text>
583
+ </g>
584
+ <!-- 35&#45;&gt;78 -->
585
+ <g id="edge130" class="edge"><title>35&#45;&gt;78</title>
586
+ <path fill="none" stroke="black" d="M10990.3,-9883.31C10947.2,-9850.14 10856,-9779.98 10807.5,-9742.63"/>
587
+ <polygon fill="black" stroke="black" points="10809.6,-9739.82 10799.5,-9736.49 10805.3,-9745.36 10809.6,-9739.82"/>
588
+ </g>
589
+ <!-- 54 -->
590
+ <g id="node54" class="node"><title>54</title>
591
+ <ellipse fill="none" stroke="black" cx="590.479" cy="-270.753" rx="142.128" ry="18.3848"/>
592
+ <text text-anchor="middle" x="590.479" y="-267.153" font-family="Times Roman,serif" font-size="14.00">n54_length27_coverage59</text>
593
+ </g>
594
+ <!-- 36&#45;&gt;54 -->
595
+ <g id="edge132" class="edge"><title>36&#45;&gt;54</title>
596
+ <path fill="none" stroke="black" d="M369.977,-318.601C411.699,-309.547 464.078,-298.181 507.316,-288.799"/>
597
+ <polygon fill="black" stroke="black" points="508.213,-292.186 517.244,-286.645 506.729,-285.345 508.213,-292.186"/>
598
+ </g>
599
+ <!-- 37 -->
600
+ <g id="node37" class="node"><title>37</title>
601
+ <ellipse fill="none" stroke="black" cx="4503.77" cy="-2409.35" rx="147.992" ry="18.3848"/>
602
+ <text text-anchor="middle" x="4503.77" y="-2405.75" font-family="Times Roman,serif" font-size="14.00">n37_length124_coverage22</text>
603
+ </g>
604
+ <!-- 37&#45;&gt;85 -->
605
+ <g id="edge134" class="edge"><title>37&#45;&gt;85</title>
606
+ <path fill="none" stroke="black" d="M4491.41,-2390.83C4460.31,-2344.27 4379.12,-2222.7 4348.01,-2176.11"/>
607
+ </g>
608
+ <!-- 38 -->
609
+ <g id="node38" class="node"><title>38</title>
610
+ <ellipse fill="none" stroke="black" cx="7122.92" cy="-4224.41" rx="142.128" ry="18.3848"/>
611
+ <text text-anchor="middle" x="7122.92" y="-4220.81" font-family="Times Roman,serif" font-size="14.00">n38_length51_coverage14</text>
612
+ </g>
613
+ <!-- 38&#45;&gt;46 -->
614
+ <g id="edge140" class="edge"><title>38&#45;&gt;46</title>
615
+ <path fill="none" stroke="blue" d="M7127.77,-4243.13C7140.66,-4292.9 7175.84,-4428.77 7191.22,-4488.14"/>
616
+ <polygon fill="blue" stroke="blue" points="7187.87,-4489.16 7193.77,-4497.97 7194.65,-4487.41 7187.87,-4489.16"/>
617
+ </g>
618
+ <!-- 58 -->
619
+ <g id="node58" class="node"><title>58</title>
620
+ <ellipse fill="none" stroke="black" cx="6833.96" cy="-4133.28" rx="142.128" ry="18.3848"/>
621
+ <text text-anchor="middle" x="6833.96" y="-4129.68" font-family="Times Roman,serif" font-size="14.00">n58_length49_coverage46</text>
622
+ </g>
623
+ <!-- 38&#45;&gt;58 -->
624
+ <g id="edge138" class="edge"><title>38&#45;&gt;58</title>
625
+ <path fill="none" stroke="black" d="M7068.57,-4207.27C7020.19,-4192.01 6949.36,-4169.68 6898.2,-4153.54"/>
626
+ <polygon fill="black" stroke="black" points="6899.15,-4150.17 6888.56,-4150.5 6897.05,-4156.85 6899.15,-4150.17"/>
627
+ </g>
628
+ <!-- 39 -->
629
+ <g id="node39" class="node"><title>39</title>
630
+ <ellipse fill="none" stroke="black" cx="9726.06" cy="-7579.15" rx="142.128" ry="18.3848"/>
631
+ <text text-anchor="middle" x="9726.06" y="-7575.55" font-family="Times Roman,serif" font-size="14.00">n39_length51_coverage28</text>
632
+ </g>
633
+ <!-- 39&#45;&gt;90 -->
634
+ <g id="edge142" class="edge"><title>39&#45;&gt;90</title>
635
+ <path fill="none" stroke="black" d="M9691.57,-7561.2C9643.15,-7536 9555.03,-7490.13 9501.98,-7462.52"/>
636
+ <polygon fill="black" stroke="black" points="9503.3,-7459.26 9492.82,-7457.75 9500.07,-7465.47 9503.3,-7459.26"/>
637
+ </g>
638
+ <!-- 66 -->
639
+ <g id="node66" class="node"><title>66</title>
640
+ <ellipse fill="none" stroke="black" cx="8586.03" cy="-6442.49" rx="142.128" ry="18.3848"/>
641
+ <text text-anchor="middle" x="8586.03" y="-6438.89" font-family="Times Roman,serif" font-size="14.00">n66_length51_coverage23</text>
642
+ </g>
643
+ <!-- 40&#45;&gt;66 -->
644
+ <g id="edge148" class="edge"><title>40&#45;&gt;66</title>
645
+ <path fill="none" stroke="blue" d="M8821.1,-6552.2C8772.03,-6529.3 8686.97,-6489.59 8633.74,-6464.75"/>
646
+ <polygon fill="blue" stroke="blue" points="8635.05,-6461.5 8624.51,-6460.44 8632.09,-6467.85 8635.05,-6461.5"/>
647
+ </g>
648
+ <!-- 74 -->
649
+ <g id="node74" class="node"><title>74</title>
650
+ <ellipse fill="none" stroke="black" cx="9130.84" cy="-6702.16" rx="147.992" ry="18.3848"/>
651
+ <text text-anchor="middle" x="9130.84" y="-6698.56" font-family="Times Roman,serif" font-size="14.00">n74_length237_coverage22</text>
652
+ </g>
653
+ <!-- 40&#45;&gt;74 -->
654
+ <g id="edge146" class="edge"><title>40&#45;&gt;74</title>
655
+ <path fill="none" stroke="black" d="M8896.29,-6588.03C8948.04,-6613.21 9041.65,-6658.76 9093.59,-6684.04"/>
656
+ </g>
657
+ <!-- 41&#45;&gt;9 -->
658
+ <g id="edge34" class="edge"><title>41&#45;&gt;9</title>
659
+ <path fill="none" stroke="black" d="M9124.86,-6984.97C9075.93,-6961.14 8989.55,-6919.07 8936.41,-6893.19"/>
660
+ <polygon fill="black" stroke="black" points="8937.74,-6889.94 8927.21,-6888.71 8934.67,-6896.24 8937.74,-6889.94"/>
661
+ </g>
662
+ <!-- 41&#45;&gt;74 -->
663
+ <g id="edge150" class="edge"><title>41&#45;&gt;74</title>
664
+ <path fill="none" stroke="black" d="M9159.8,-6984.12C9154.57,-6933.16 9140.09,-6792.22 9133.81,-6731.08"/>
665
+ <polygon fill="black" stroke="black" points="9137.27,-6730.56 9132.77,-6720.97 9130.31,-6731.27 9137.27,-6730.56"/>
666
+ </g>
667
+ <!-- 42 -->
668
+ <g id="node42" class="node"><title>42</title>
669
+ <ellipse fill="none" stroke="black" cx="6544.24" cy="-4044.55" rx="142.128" ry="18.3848"/>
670
+ <text text-anchor="middle" x="6544.24" y="-4040.95" font-family="Times Roman,serif" font-size="14.00">n42_length51_coverage25</text>
671
+ </g>
672
+ <!-- 42&#45;&gt;51 -->
673
+ <g id="edge154" class="edge"><title>42&#45;&gt;51</title>
674
+ <path fill="none" stroke="black" d="M6539.17,-4025.92C6525.72,-3976.5 6489.06,-3841.81 6472.92,-3782.5"/>
675
+ <polygon fill="black" stroke="black" points="6476.25,-3781.4 6470.24,-3772.67 6469.49,-3783.24 6476.25,-3781.4"/>
676
+ </g>
677
+ <!-- 43&#45;&gt;62 -->
678
+ <g id="edge158" class="edge"><title>43&#45;&gt;62</title>
679
+ <path fill="none" stroke="black" d="M2966.46,-1401.91C2994.14,-1446.44 3064.74,-1560.03 3097.38,-1612.55"/>
680
+ <polygon fill="black" stroke="black" points="3094.58,-1614.68 3102.83,-1621.32 3100.53,-1610.98 3094.58,-1614.68"/>
681
+ </g>
682
+ <!-- 80 -->
683
+ <g id="node80" class="node"><title>80</title>
684
+ <ellipse fill="none" stroke="black" cx="2653.46" cy="-1390.69" rx="142.128" ry="18.3848"/>
685
+ <text text-anchor="middle" x="2653.46" y="-1387.09" font-family="Times Roman,serif" font-size="14.00">n80_length51_coverage18</text>
686
+ </g>
687
+ <!-- 43&#45;&gt;80 -->
688
+ <g id="edge160" class="edge"><title>43&#45;&gt;80</title>
689
+ <path fill="none" stroke="blue" d="M2815.26,-1386.82C2811.41,-1386.91 2807.56,-1387 2803.7,-1387.09"/>
690
+ <polygon fill="blue" stroke="blue" points="2803.41,-1383.6 2793.5,-1387.34 2803.58,-1390.6 2803.41,-1383.6"/>
691
+ </g>
692
+ <!-- 44 -->
693
+ <g id="node44" class="node"><title>44</title>
694
+ <ellipse fill="none" stroke="black" cx="5102.9" cy="-2381.94" rx="142.128" ry="18.3848"/>
695
+ <text text-anchor="middle" x="5102.9" y="-2378.34" font-family="Times Roman,serif" font-size="14.00">n44_length65_coverage24</text>
696
+ </g>
697
+ <!-- 88 -->
698
+ <g id="node88" class="node"><title>88</title>
699
+ <ellipse fill="none" stroke="black" cx="4805.41" cy="-2401.69" rx="142.128" ry="18.3848"/>
700
+ <text text-anchor="middle" x="4805.41" y="-2398.09" font-family="Times Roman,serif" font-size="14.00">n88_length11_coverage46</text>
701
+ </g>
702
+ <!-- 44&#45;&gt;88 -->
703
+ <g id="edge162" class="edge"><title>44&#45;&gt;88</title>
704
+ <path fill="none" stroke="black" d="M4976.31,-2390.34C4965.17,-2391.08 4953.86,-2391.83 4942.64,-2392.58"/>
705
+ <polygon fill="black" stroke="black" points="4942.11,-2389.11 4932.37,-2393.26 4942.58,-2396.09 4942.11,-2389.11"/>
706
+ </g>
707
+ <!-- 65 -->
708
+ <g id="node65" class="node"><title>65</title>
709
+ <ellipse fill="none" stroke="black" cx="7615.12" cy="-5203.86" rx="142.128" ry="18.3848"/>
710
+ <text text-anchor="middle" x="7615.12" y="-5200.26" font-family="Times Roman,serif" font-size="14.00">n65_length51_coverage14</text>
711
+ </g>
712
+ <!-- 45&#45;&gt;65 -->
713
+ <g id="edge166" class="edge"><title>45&#45;&gt;65</title>
714
+ <path fill="none" stroke="black" d="M7557.84,-4926.71C7568.17,-4976.68 7596.69,-5114.67 7609.15,-5175"/>
715
+ <polygon fill="black" stroke="black" points="7605.77,-5175.91 7611.22,-5184.99 7612.62,-5174.49 7605.77,-5175.91"/>
716
+ </g>
717
+ <!-- 82 -->
718
+ <g id="node82" class="node"><title>82</title>
719
+ <ellipse fill="none" stroke="black" cx="1368.21" cy="-438.022" rx="142.128" ry="18.3848"/>
720
+ <text text-anchor="middle" x="1368.21" y="-434.422" font-family="Times Roman,serif" font-size="14.00">n82_length75_coverage32</text>
721
+ </g>
722
+ <!-- 47&#45;&gt;82 -->
723
+ <g id="edge170" class="edge"><title>47&#45;&gt;82</title>
724
+ <path fill="none" stroke="black" d="M1532.08,-661.834C1499.04,-616.708 1414.98,-501.898 1381.89,-456.706"/>
725
+ </g>
726
+ <!-- 48&#45;&gt;44 -->
727
+ <g id="edge164" class="edge"><title>48&#45;&gt;44</title>
728
+ <path fill="none" stroke="black" d="M5303.31,-2545.53C5263.07,-2512.68 5179,-2444.05 5133.59,-2406.98"/>
729
+ <polygon fill="black" stroke="black" points="5135.53,-2404.05 5125.57,-2400.44 5131.11,-2409.48 5135.53,-2404.05"/>
730
+ </g>
731
+ <!-- 87 -->
732
+ <g id="node87" class="node"><title>87</title>
733
+ <ellipse fill="none" stroke="black" cx="5011.16" cy="-2617.73" rx="142.128" ry="18.3848"/>
734
+ <text text-anchor="middle" x="5011.16" y="-2614.13" font-family="Times Roman,serif" font-size="14.00">n87_length65_coverage24</text>
735
+ </g>
736
+ <!-- 48&#45;&gt;87 -->
737
+ <g id="edge174" class="edge"><title>48&#45;&gt;87</title>
738
+ <path fill="none" stroke="black" d="M5238.25,-2578.96C5197.58,-2585.9 5149.12,-2594.17 5107.44,-2601.29"/>
739
+ <polygon fill="black" stroke="black" points="5106.82,-2597.85 5097.55,-2602.98 5108,-2604.75 5106.82,-2597.85"/>
740
+ </g>
741
+ <!-- 49&#45;&gt;13 -->
742
+ <g id="edge48" class="edge"><title>49&#45;&gt;13</title>
743
+ <path fill="none" stroke="black" d="M7894.18,-5291.36C7883.93,-5241.19 7855.59,-5102.4 7843.29,-5042.2"/>
744
+ <polygon fill="black" stroke="black" points="7846.69,-5041.34 7841.26,-5032.24 7839.83,-5042.74 7846.69,-5041.34"/>
745
+ </g>
746
+ <!-- 49&#45;&gt;65 -->
747
+ <g id="edge178" class="edge"><title>49&#45;&gt;65</title>
748
+ <path fill="none" stroke="black" d="M7851.25,-5292.38C7798.85,-5272.73 7714.33,-5241.05 7661.89,-5221.39"/>
749
+ </g>
750
+ <!-- 76 -->
751
+ <g id="node76" class="node"><title>76</title>
752
+ <ellipse fill="none" stroke="black" cx="7950.15" cy="-5607.46" rx="142.128" ry="18.3848"/>
753
+ <text text-anchor="middle" x="7950.15" y="-5603.86" font-family="Times Roman,serif" font-size="14.00">n76_length96_coverage21</text>
754
+ </g>
755
+ <!-- 49&#45;&gt;76 -->
756
+ <g id="edge180" class="edge"><title>49&#45;&gt;76</title>
757
+ <path fill="none" stroke="blue" d="M7901.23,-5328.5C7910.07,-5378.92 7934.53,-5518.36 7945.14,-5578.85"/>
758
+ <polygon fill="blue" stroke="blue" points="7941.72,-5579.61 7946.89,-5588.86 7948.61,-5578.4 7941.72,-5579.61"/>
759
+ </g>
760
+ <!-- 50 -->
761
+ <g id="node50" class="node"><title>50</title>
762
+ <ellipse fill="none" stroke="black" cx="10794.9" cy="-9416.32" rx="142.128" ry="18.3848"/>
763
+ <text text-anchor="middle" x="10794.9" y="-9412.72" font-family="Times Roman,serif" font-size="14.00">n50_length51_coverage24</text>
764
+ </g>
765
+ <!-- 50&#45;&gt;70 -->
766
+ <g id="edge184" class="edge"><title>50&#45;&gt;70</title>
767
+ <path fill="none" stroke="blue" d="M10768.4,-9397.87C10723.3,-9366.49 10631.9,-9302.78 10581.9,-9267.95"/>
768
+ <polygon fill="blue" stroke="blue" points="10583.9,-9265.05 10573.7,-9262.2 10579.9,-9270.79 10583.9,-9265.05"/>
769
+ </g>
770
+ <!-- 50&#45;&gt;78 -->
771
+ <g id="edge182" class="edge"><title>50&#45;&gt;78</title>
772
+ <path fill="none" stroke="black" d="M10793.6,-9435.2C10790.2,-9489.38 10780.2,-9644.98 10776.7,-9699.16"/>
773
+ </g>
774
+ <!-- 68 -->
775
+ <g id="node68" class="node"><title>68</title>
776
+ <ellipse fill="none" stroke="black" cx="6176.99" cy="-3659.33" rx="147.992" ry="18.3848"/>
777
+ <text text-anchor="middle" x="6176.99" y="-3655.73" font-family="Times Roman,serif" font-size="14.00">n68_length148_coverage27</text>
778
+ </g>
779
+ <!-- 51&#45;&gt;68 -->
780
+ <g id="edge186" class="edge"><title>51&#45;&gt;68</title>
781
+ <path fill="none" stroke="black" d="M6412.6,-3736.6C6360.82,-3719.62 6282.11,-3693.8 6230.12,-3676.76"/>
782
+ </g>
783
+ <!-- 52&#45;&gt;24 -->
784
+ <g id="edge94" class="edge"><title>52&#45;&gt;24</title>
785
+ <path fill="none" stroke="black" d="M10297,-8799.15C10296.3,-8850.24 10294.4,-8991.56 10293.6,-9052.87"/>
786
+ <polygon fill="black" stroke="black" points="10290.1,-9052.96 10293.5,-9063.01 10297.1,-9053.06 10290.1,-9052.96"/>
787
+ </g>
788
+ <!-- 71 -->
789
+ <g id="node71" class="node"><title>71</title>
790
+ <ellipse fill="none" stroke="black" cx="10552.4" cy="-8941.83" rx="147.992" ry="18.3848"/>
791
+ <text text-anchor="middle" x="10552.4" y="-8938.23" font-family="Times Roman,serif" font-size="14.00">n71_length126_coverage25</text>
792
+ </g>
793
+ <!-- 52&#45;&gt;71 -->
794
+ <g id="edge190" class="edge"><title>52&#45;&gt;71</title>
795
+ <path fill="none" stroke="black" d="M10326,-8798.5C10375.2,-8829.61 10474.7,-8892.62 10523.8,-8923.68"/>
796
+ </g>
797
+ <!-- 81 -->
798
+ <g id="node81" class="node"><title>81</title>
799
+ <ellipse fill="none" stroke="black" cx="10290.4" cy="-8478.45" rx="142.128" ry="18.3848"/>
800
+ <text text-anchor="middle" x="10290.4" y="-8474.85" font-family="Times Roman,serif" font-size="14.00">n81_length54_coverage27</text>
801
+ </g>
802
+ <!-- 52&#45;&gt;81 -->
803
+ <g id="edge192" class="edge"><title>52&#45;&gt;81</title>
804
+ <path fill="none" stroke="blue" d="M10296.8,-8761.4C10295.7,-8710.27 10292.5,-8568.83 10291.1,-8507.47"/>
805
+ <polygon fill="blue" stroke="blue" points="10294.6,-8507.24 10290.8,-8497.32 10287.6,-8507.4 10294.6,-8507.24"/>
806
+ </g>
807
+ <!-- 53&#45;&gt;11 -->
808
+ <g id="edge40" class="edge"><title>53&#45;&gt;11</title>
809
+ <path fill="none" stroke="black" d="M8226.32,-5703.01C8217.58,-5652.52 8193.4,-5512.87 8182.91,-5452.29"/>
810
+ <polygon fill="black" stroke="black" points="8186.33,-5451.53 8181.17,-5442.27 8179.43,-5452.72 8186.33,-5451.53"/>
811
+ </g>
812
+ <!-- 53&#45;&gt;76 -->
813
+ <g id="edge194" class="edge"><title>53&#45;&gt;76</title>
814
+ <path fill="none" stroke="black" d="M8186.2,-5703.93C8133.78,-5682.51 8046.07,-5646.66 7993.6,-5625.22"/>
815
+ </g>
816
+ <!-- 96 -->
817
+ <g id="node96" class="node"><title>96</title>
818
+ <ellipse fill="none" stroke="black" cx="8506.13" cy="-5842.92" rx="142.128" ry="18.3848"/>
819
+ <text text-anchor="middle" x="8506.13" y="-5839.32" font-family="Times Roman,serif" font-size="14.00">n96_length96_coverage22</text>
820
+ </g>
821
+ <!-- 53&#45;&gt;96 -->
822
+ <g id="edge196" class="edge"><title>53&#45;&gt;96</title>
823
+ <path fill="none" stroke="blue" d="M8270.06,-5739.41C8319.46,-5761.07 8402.94,-5797.67 8456.25,-5821.05"/>
824
+ <polygon fill="blue" stroke="blue" points="8454.95,-5824.3 8465.51,-5825.11 8457.76,-5817.89 8454.95,-5824.3"/>
825
+ </g>
826
+ <!-- 54&#45;&gt;34 -->
827
+ <g id="edge128" class="edge"><title>54&#45;&gt;34</title>
828
+ <path fill="none" stroke="black" d="M689.915,-257.448C718.145,-253.67 749.062,-249.533 777.938,-245.669"/>
829
+ <polygon fill="black" stroke="black" points="778.612,-249.111 788.059,-244.315 777.683,-242.172 778.612,-249.111"/>
830
+ </g>
831
+ <!-- 75 -->
832
+ <g id="node75" class="node"><title>75</title>
833
+ <ellipse fill="none" stroke="black" cx="770.048" cy="-510.317" rx="147.992" ry="18.3848"/>
834
+ <text text-anchor="middle" x="770.048" y="-506.717" font-family="Times Roman,serif" font-size="14.00">n75_length129_coverage27</text>
835
+ </g>
836
+ <!-- 54&#45;&gt;75 -->
837
+ <g id="edge198" class="edge"><title>54&#45;&gt;75</title>
838
+ <path fill="none" stroke="black" d="M604.569,-289.551C636.236,-331.798 713.125,-434.376 749.859,-483.383"/>
839
+ <polygon fill="black" stroke="black" points="747.225,-485.704 756.023,-491.606 752.826,-481.506 747.225,-485.704"/>
840
+ </g>
841
+ <!-- 55&#45;&gt;31 -->
842
+ <g id="edge120" class="edge"><title>55&#45;&gt;31</title>
843
+ <path fill="none" stroke="black" d="M3886.43,-1917.13C3914.06,-1961.82 3984.54,-2075.81 4017.12,-2128.51"/>
844
+ <polygon fill="black" stroke="black" points="4014.33,-2130.65 4022.56,-2137.31 4020.28,-2126.96 4014.33,-2130.65"/>
845
+ </g>
846
+ <!-- 61 -->
847
+ <g id="node61" class="node"><title>61</title>
848
+ <ellipse fill="none" stroke="black" cx="3573.49" cy="-1896.62" rx="147.992" ry="18.3848"/>
849
+ <text text-anchor="middle" x="3573.49" y="-1893.02" font-family="Times Roman,serif" font-size="14.00">n61_length267_coverage24</text>
850
+ </g>
851
+ <!-- 55&#45;&gt;61 -->
852
+ <g id="edge204" class="edge"><title>55&#45;&gt;61</title>
853
+ <path fill="none" stroke="blue" d="M3733.06,-1897.68C3732.59,-1897.68 3732.11,-1897.67 3731.63,-1897.67"/>
854
+ <polygon fill="blue" stroke="blue" points="3731.62,-1894.17 3721.6,-1897.6 3731.57,-1901.17 3731.62,-1894.17"/>
855
+ </g>
856
+ <!-- 84 -->
857
+ <g id="node84" class="node"><title>84</title>
858
+ <ellipse fill="none" stroke="black" cx="4176.36" cy="-1900.23" rx="142.128" ry="18.3848"/>
859
+ <text text-anchor="middle" x="4176.36" y="-1896.63" font-family="Times Roman,serif" font-size="14.00">n84_length78_coverage19</text>
860
+ </g>
861
+ <!-- 55&#45;&gt;84 -->
862
+ <g id="edge202" class="edge"><title>55&#45;&gt;84</title>
863
+ <path fill="none" stroke="black" d="M4017.29,-1899.38C4019.58,-1899.4 4021.87,-1899.41 4024.17,-1899.42"/>
864
+ <polygon fill="black" stroke="black" points="4024.2,-1902.92 4034.22,-1899.47 4024.24,-1895.92 4024.2,-1902.92"/>
865
+ </g>
866
+ <!-- 73 -->
867
+ <g id="node73" class="node"><title>73</title>
868
+ <ellipse fill="none" stroke="black" cx="11380.6" cy="-10891.8" rx="142.128" ry="18.3848"/>
869
+ <text text-anchor="middle" x="11380.6" y="-10888.2" font-family="Times Roman,serif" font-size="14.00">n73_length51_coverage25</text>
870
+ </g>
871
+ <!-- 56&#45;&gt;73 -->
872
+ <g id="edge206" class="edge"><title>56&#45;&gt;73</title>
873
+ <path fill="none" stroke="black" d="M11178.1,-10711.6C11218.1,-10747.1 11306.3,-10825.7 11352,-10866.3"/>
874
+ <polygon fill="black" stroke="black" points="11349.9,-10869.2 11359.7,-10873.2 11354.6,-10864 11349.9,-10869.2"/>
875
+ </g>
876
+ <!-- 57 -->
877
+ <g id="node57" class="node"><title>57</title>
878
+ <ellipse fill="none" stroke="black" cx="11458.5" cy="-11650.7" rx="142.128" ry="18.3848"/>
879
+ <text text-anchor="middle" x="11458.5" y="-11647.1" font-family="Times Roman,serif" font-size="14.00">n57_length53_coverage17</text>
880
+ </g>
881
+ <!-- 57&#45;&gt;23 -->
882
+ <g id="edge90" class="edge"><title>57&#45;&gt;23</title>
883
+ <path fill="none" stroke="black" d="M11434.2,-11632.3C11392.1,-11600.4 11306,-11535.2 11259,-11499.6"/>
884
+ <polygon fill="black" stroke="black" points="11261,-11496.7 11250.9,-11493.5 11256.8,-11502.3 11261,-11496.7"/>
885
+ </g>
886
+ <!-- 83 -->
887
+ <g id="node83" class="node"><title>83</title>
888
+ <ellipse fill="none" stroke="black" cx="11550.6" cy="-11371.8" rx="147.992" ry="18.3848"/>
889
+ <text text-anchor="middle" x="11550.6" y="-11368.2" font-family="Times Roman,serif" font-size="14.00">n83_length174_coverage25</text>
890
+ </g>
891
+ <!-- 57&#45;&gt;83 -->
892
+ <g id="edge210" class="edge"><title>57&#45;&gt;83</title>
893
+ <path fill="none" stroke="black" d="M11464.7,-11632C11480.5,-11584.2 11522.4,-11457.3 11541.2,-11400.3"/>
894
+ <polygon fill="black" stroke="black" points="11544.6,-11401.1 11544.4,-11390.5 11538,-11398.9 11544.6,-11401.1"/>
895
+ </g>
896
+ <!-- 58&#45;&gt;42 -->
897
+ <g id="edge156" class="edge"><title>58&#45;&gt;42</title>
898
+ <path fill="none" stroke="black" d="M6778.1,-4116.18C6729.91,-4101.42 6660.25,-4080.08 6609.5,-4064.54"/>
899
+ <polygon fill="black" stroke="black" points="6610.52,-4061.19 6599.93,-4061.61 6608.47,-4067.88 6610.52,-4061.19"/>
900
+ </g>
901
+ <!-- 86 -->
902
+ <g id="node86" class="node"><title>86</title>
903
+ <ellipse fill="none" stroke="black" cx="6754.97" cy="-3842.46" rx="142.128" ry="18.3848"/>
904
+ <text text-anchor="middle" x="6754.97" y="-3838.86" font-family="Times Roman,serif" font-size="14.00">n86_length51_coverage16</text>
905
+ </g>
906
+ <!-- 58&#45;&gt;86 -->
907
+ <g id="edge212" class="edge"><title>58&#45;&gt;86</title>
908
+ <path fill="none" stroke="black" d="M6828.9,-4114.65C6815.47,-4065.21 6778.87,-3930.48 6762.76,-3871.15"/>
909
+ <polygon fill="black" stroke="black" points="6766.09,-3870.05 6760.09,-3861.32 6759.33,-3871.89 6766.09,-3870.05"/>
910
+ </g>
911
+ <!-- 93 -->
912
+ <g id="node93" class="node"><title>93</title>
913
+ <ellipse fill="none" stroke="black" cx="6910.12" cy="-4424.93" rx="142.128" ry="18.3848"/>
914
+ <text text-anchor="middle" x="6910.12" y="-4421.33" font-family="Times Roman,serif" font-size="14.00">n93_length51_coverage24</text>
915
+ </g>
916
+ <!-- 58&#45;&gt;93 -->
917
+ <g id="edge214" class="edge"><title>58&#45;&gt;93</title>
918
+ <path fill="none" stroke="blue" d="M6838.84,-4151.97C6851.82,-4201.67 6887.24,-4337.31 6902.72,-4396.59"/>
919
+ <polygon fill="blue" stroke="blue" points="6899.37,-4397.61 6905.28,-4406.4 6906.14,-4395.84 6899.37,-4397.61"/>
920
+ </g>
921
+ <!-- 59&#45;&gt;83 -->
922
+ <g id="edge216" class="edge"><title>59&#45;&gt;83</title>
923
+ <path fill="none" stroke="black" d="M11339.7,-11205.5C11384.6,-11240.9 11482.5,-11318.2 11527.3,-11353.5"/>
924
+ </g>
925
+ <!-- 60&#45;&gt;32 -->
926
+ <g id="edge124" class="edge"><title>60&#45;&gt;32</title>
927
+ <path fill="none" stroke="black" d="M10028.2,-8307.55C10025.5,-8256.48 10018.2,-8115.23 10014.9,-8053.96"/>
928
+ <polygon fill="black" stroke="black" points="10018.4,-8053.62 10014.4,-8043.82 10011.4,-8053.99 10018.4,-8053.62"/>
929
+ </g>
930
+ <!-- 94 -->
931
+ <g id="node94" class="node"><title>94</title>
932
+ <ellipse fill="none" stroke="black" cx="9764.15" cy="-8181.49" rx="147.992" ry="18.3848"/>
933
+ <text text-anchor="middle" x="9764.15" y="-8177.89" font-family="Times Roman,serif" font-size="14.00">n94_length102_coverage23</text>
934
+ </g>
935
+ <!-- 60&#45;&gt;94 -->
936
+ <g id="edge220" class="edge"><title>60&#45;&gt;94</title>
937
+ <path fill="none" stroke="black" d="M9996.17,-8308.35C9948.12,-8282.08 9858.96,-8233.33 9806.26,-8204.52"/>
938
+ <polygon fill="black" stroke="black" points="9807.63,-8201.28 9797.18,-8199.55 9804.27,-8207.42 9807.63,-8201.28"/>
939
+ </g>
940
+ <!-- 61&#45;&gt;16 -->
941
+ <g id="edge62" class="edge"><title>61&#45;&gt;16</title>
942
+ <path fill="none" stroke="black" d="M3562.16,-1878.06C3534.81,-1833.26 3465.05,-1718.99 3432.8,-1666.15"/>
943
+ <polygon fill="black" stroke="black" points="3435.61,-1664.04 3427.41,-1657.33 3429.63,-1667.69 3435.61,-1664.04"/>
944
+ </g>
945
+ <!-- 63&#45;&gt;47 -->
946
+ <g id="edge172" class="edge"><title>63&#45;&gt;47</title>
947
+ <path fill="none" stroke="black" d="M1706.29,-907.477C1675.93,-864.562 1600.47,-757.876 1564.87,-707.549"/>
948
+ <polygon fill="black" stroke="black" points="1567.54,-705.263 1558.91,-699.12 1561.83,-709.305 1567.54,-705.263"/>
949
+ </g>
950
+ <!-- 64 -->
951
+ <g id="node64" class="node"><title>64</title>
952
+ <ellipse fill="none" stroke="black" cx="4636.6" cy="-2151.72" rx="147.992" ry="18.3848"/>
953
+ <text text-anchor="middle" x="4636.6" y="-2148.12" font-family="Times Roman,serif" font-size="14.00">n64_length124_coverage27</text>
954
+ </g>
955
+ <!-- 64&#45;&gt;88 -->
956
+ <g id="edge224" class="edge"><title>64&#45;&gt;88</title>
957
+ <path fill="none" stroke="black" d="M4649.28,-2170.51C4680.65,-2216.95 4761.53,-2336.72 4792.8,-2383.03"/>
958
+ </g>
959
+ <!-- 66&#45;&gt;98 -->
960
+ <g id="edge228" class="edge"><title>66&#45;&gt;98</title>
961
+ <path fill="none" stroke="black" d="M8583.74,-6423.71C8577.54,-6372.86 8560.39,-6232.22 8552.94,-6171.2"/>
962
+ <polygon fill="black" stroke="black" points="8556.4,-6170.61 8551.71,-6161.11 8549.45,-6171.46 8556.4,-6170.61"/>
963
+ </g>
964
+ <!-- 67 -->
965
+ <g id="node67" class="node"><title>67</title>
966
+ <ellipse fill="none" stroke="black" cx="5503.49" cy="-2291.14" rx="142.128" ry="18.3848"/>
967
+ <text text-anchor="middle" x="5503.49" y="-2287.54" font-family="Times Roman,serif" font-size="14.00">n67_length50_coverage13</text>
968
+ </g>
969
+ <!-- 67&#45;&gt;48 -->
970
+ <g id="edge176" class="edge"><title>67&#45;&gt;48</title>
971
+ <path fill="none" stroke="black" d="M5491.28,-2309.89C5460.48,-2357.22 5379.5,-2481.66 5343.55,-2536.9"/>
972
+ <polygon fill="black" stroke="black" points="5340.5,-2535.17 5337.98,-2545.46 5346.37,-2538.99 5340.5,-2535.17"/>
973
+ </g>
974
+ <!-- 68&#45;&gt;99 -->
975
+ <g id="edge230" class="edge"><title>68&#45;&gt;99</title>
976
+ <path fill="none" stroke="blue" d="M6172.31,-3640.59C6159.86,-3590.76 6125.86,-3454.72 6111.01,-3395.28"/>
977
+ <polygon fill="blue" stroke="blue" points="6114.37,-3394.29 6108.55,-3385.44 6107.58,-3395.99 6114.37,-3394.29"/>
978
+ </g>
979
+ <!-- 69 -->
980
+ <g id="node69" class="node"><title>69</title>
981
+ <ellipse fill="none" stroke="black" cx="10529.3" cy="-9545.11" rx="142.128" ry="18.3848"/>
982
+ <text text-anchor="middle" x="10529.3" y="-9541.51" font-family="Times Roman,serif" font-size="14.00">n69_length51_coverage25</text>
983
+ </g>
984
+ <!-- 69&#45;&gt;70 -->
985
+ <g id="edge232" class="edge"><title>69&#45;&gt;70</title>
986
+ <path fill="none" stroke="black" d="M10530.5,-9526.27C10533.5,-9475.23 10542,-9334.08 10545.7,-9272.85"/>
987
+ <polygon fill="black" stroke="black" points="10549.2,-9272.91 10546.3,-9262.72 10542.2,-9272.49 10549.2,-9272.91"/>
988
+ </g>
989
+ <!-- 70&#45;&gt;71 -->
990
+ <g id="edge236" class="edge"><title>70&#45;&gt;71</title>
991
+ <path fill="none" stroke="black" d="M10547.7,-9224.99C10548.6,-9173.69 10550.9,-9031.6 10551.9,-8970.44"/>
992
+ <polygon fill="black" stroke="black" points="10555.5,-8970.39 10552.1,-8960.33 10548.5,-8970.27 10555.5,-8970.39"/>
993
+ </g>
994
+ <!-- 73&#45;&gt;59 -->
995
+ <g id="edge218" class="edge"><title>73&#45;&gt;59</title>
996
+ <path fill="none" stroke="black" d="M11376.4,-10910.7C11365.5,-10961 11335.7,-11098.4 11322.6,-11158.4"/>
997
+ <polygon fill="black" stroke="black" points="11319.2,-11157.8 11320.5,-11168.3 11326,-11159.3 11319.2,-11157.8"/>
998
+ </g>
999
+ <!-- 75&#45;&gt;97 -->
1000
+ <g id="edge238" class="edge"><title>75&#45;&gt;97</title>
1001
+ <path fill="none" stroke="black" d="M871.422,-496.8C903.587,-492.511 939.065,-487.78 970.937,-483.53"/>
1002
+ </g>
1003
+ <!-- 77&#45;&gt;78 -->
1004
+ <g id="edge240" class="edge"><title>77&#45;&gt;78</title>
1005
+ <path fill="none" stroke="black" d="M10743.8,-9999.37C10749.5,-9948.52 10765.4,-9807.89 10772.3,-9746.88"/>
1006
+ <polygon fill="black" stroke="black" points="10775.8,-9747.12 10773.4,-9736.79 10768.8,-9746.33 10775.8,-9747.12"/>
1007
+ </g>
1008
+ <!-- 78&#45;&gt;69 -->
1009
+ <g id="edge234" class="edge"><title>78&#45;&gt;69</title>
1010
+ <path fill="none" stroke="black" d="M10749.2,-9699.52C10704.4,-9668.06 10613.4,-9604.16 10563.7,-9569.24"/>
1011
+ <polygon fill="black" stroke="black" points="10565.7,-9566.36 10555.5,-9563.48 10561.7,-9572.09 10565.7,-9566.36"/>
1012
+ </g>
1013
+ <!-- 79&#45;&gt;54 -->
1014
+ <g id="edge200" class="edge"><title>79&#45;&gt;54</title>
1015
+ <path fill="none" stroke="black" d="M440.286,-37.9752C468.568,-81.8079 539.83,-192.254 572.996,-243.658"/>
1016
+ <polygon fill="black" stroke="black" points="570.178,-245.746 578.541,-252.251 576.06,-241.951 570.178,-245.746"/>
1017
+ </g>
1018
+ <!-- 80&#45;&gt;6 -->
1019
+ <g id="edge24" class="edge"><title>80&#45;&gt;6</title>
1020
+ <path fill="none" stroke="black" d="M2641.44,-1372.05C2612.93,-1327.83 2541.11,-1216.39 2507.68,-1164.53"/>
1021
+ <polygon fill="black" stroke="black" points="2510.45,-1162.37 2502.09,-1155.86 2504.56,-1166.16 2510.45,-1162.37"/>
1022
+ </g>
1023
+ <!-- 81&#45;&gt;60 -->
1024
+ <g id="edge222" class="edge"><title>81&#45;&gt;60</title>
1025
+ <path fill="none" stroke="black" d="M10259.2,-8460.26C10211.7,-8432.62 10121.3,-8380.04 10069.1,-8349.66"/>
1026
+ <polygon fill="black" stroke="black" points="10070.9,-8346.62 10060.5,-8344.62 10067.4,-8352.67 10070.9,-8346.62"/>
1027
+ </g>
1028
+ <!-- 82&#45;&gt;97 -->
1029
+ <g id="edge242" class="edge"><title>82&#45;&gt;97</title>
1030
+ <path fill="none" stroke="blue" d="M1259.07,-449.858C1234.92,-452.477 1209.25,-455.262 1184.82,-457.911"/>
1031
+ <polygon fill="blue" stroke="blue" points="1184.37,-454.44 1174.8,-458.998 1185.12,-461.399 1184.37,-454.44"/>
1032
+ </g>
1033
+ <!-- 84&#45;&gt;85 -->
1034
+ <g id="edge244" class="edge"><title>84&#45;&gt;85</title>
1035
+ <path fill="none" stroke="black" d="M4187.81,-1918.74C4215.47,-1963.42 4286,-2077.39 4318.62,-2130.08"/>
1036
+ <polygon fill="black" stroke="black" points="4315.82,-2132.22 4324.06,-2138.88 4321.78,-2128.54 4315.82,-2132.22"/>
1037
+ </g>
1038
+ <!-- 85&#45;&gt;64 -->
1039
+ <g id="edge226" class="edge"><title>85&#45;&gt;64</title>
1040
+ <path fill="none" stroke="black" d="M4476.42,-2154.83C4477.57,-2154.81 4478.71,-2154.79 4479.86,-2154.77"/>
1041
+ <polygon fill="black" stroke="black" points="4480.28,-2158.26 4490.21,-2154.56 4480.14,-2151.26 4480.28,-2158.26"/>
1042
+ </g>
1043
+ <!-- 86&#45;&gt;51 -->
1044
+ <g id="edge188" class="edge"><title>86&#45;&gt;51</title>
1045
+ <path fill="none" stroke="black" d="M6699.08,-3825.37C6650.86,-3810.62 6581.17,-3789.31 6530.4,-3773.79"/>
1046
+ <polygon fill="black" stroke="black" points="6531.41,-3770.44 6520.83,-3770.86 6529.37,-3777.13 6531.41,-3770.44"/>
1047
+ </g>
1048
+ <!-- 87&#45;&gt;88 -->
1049
+ <g id="edge246" class="edge"><title>87&#45;&gt;88</title>
1050
+ <path fill="none" stroke="black" d="M4993.62,-2599.31C4956.95,-2560.81 4872.1,-2471.72 4830.01,-2427.52"/>
1051
+ <polygon fill="black" stroke="black" points="4832.34,-2424.89 4822.91,-2420.07 4827.27,-2429.72 4832.34,-2424.89"/>
1052
+ </g>
1053
+ <!-- 88&#45;&gt;37 -->
1054
+ <g id="edge136" class="edge"><title>88&#45;&gt;37</title>
1055
+ <path fill="none" stroke="black" d="M4665.63,-2405.24C4663.46,-2405.3 4661.29,-2405.35 4659.12,-2405.41"/>
1056
+ <polygon fill="black" stroke="black" points="4658.86,-2401.91 4648.96,-2405.66 4659.04,-2408.91 4658.86,-2401.91"/>
1057
+ </g>
1058
+ <!-- 89 -->
1059
+ <g id="node89" class="node"><title>89</title>
1060
+ <ellipse fill="none" stroke="black" cx="9480.14" cy="-7740.67" rx="142.128" ry="18.3848"/>
1061
+ <text text-anchor="middle" x="9480.14" y="-7737.07" font-family="Times Roman,serif" font-size="14.00">n89_length51_coverage23</text>
1062
+ </g>
1063
+ <!-- 89&#45;&gt;90 -->
1064
+ <g id="edge248" class="edge"><title>89&#45;&gt;90</title>
1065
+ <path fill="none" stroke="black" d="M9478.76,-7721.84C9475.01,-7670.84 9464.65,-7529.78 9460.16,-7468.59"/>
1066
+ <polygon fill="black" stroke="black" points="9463.64,-7468.18 9459.42,-7458.47 9456.66,-7468.7 9463.64,-7468.18"/>
1067
+ </g>
1068
+ <!-- 91 -->
1069
+ <g id="node91" class="node"><title>91</title>
1070
+ <ellipse fill="none" stroke="black" cx="9431.5" cy="-7138.66" rx="142.128" ry="18.3848"/>
1071
+ <text text-anchor="middle" x="9431.5" y="-7135.06" font-family="Times Roman,serif" font-size="14.00">n91_length51_coverage25</text>
1072
+ </g>
1073
+ <!-- 90&#45;&gt;91 -->
1074
+ <g id="edge252" class="edge"><title>90&#45;&gt;91</title>
1075
+ <path fill="none" stroke="black" d="M9456.37,-7420.82C9451.88,-7369.83 9439.45,-7228.79 9434.05,-7167.6"/>
1076
+ <polygon fill="black" stroke="black" points="9437.52,-7167.14 9433.16,-7157.48 9430.55,-7167.75 9437.52,-7167.14"/>
1077
+ </g>
1078
+ <!-- 91&#45;&gt;41 -->
1079
+ <g id="edge152" class="edge"><title>91&#45;&gt;41</title>
1080
+ <path fill="none" stroke="black" d="M9395.68,-7120.64C9347,-7096.15 9259.98,-7052.36 9206.89,-7025.65"/>
1081
+ <polygon fill="black" stroke="black" points="9208.21,-7022.4 9197.71,-7021.03 9205.07,-7028.65 9208.21,-7022.4"/>
1082
+ </g>
1083
+ <!-- 92&#45;&gt;56 -->
1084
+ <g id="edge208" class="edge"><title>92&#45;&gt;56</title>
1085
+ <path fill="none" stroke="black" d="M11205.3,-10413.7C11196.7,-10464.2 11172.8,-10604 11162.5,-10664.6"/>
1086
+ <polygon fill="black" stroke="black" points="11159,-10664.1 11160.7,-10674.6 11165.9,-10665.3 11159,-10664.1"/>
1087
+ </g>
1088
+ <!-- 93&#45;&gt;46 -->
1089
+ <g id="edge168" class="edge"><title>93&#45;&gt;46</title>
1090
+ <path fill="none" stroke="black" d="M6964.04,-4442.05C7012.45,-4457.43 7083.57,-4480.01 7134.79,-4496.27"/>
1091
+ <polygon fill="black" stroke="black" points="7133.84,-4499.65 7144.43,-4499.34 7135.96,-4492.97 7133.84,-4499.65"/>
1092
+ </g>
1093
+ <!-- 94&#45;&gt;95 -->
1094
+ <g id="edge254" class="edge"><title>94&#45;&gt;95</title>
1095
+ <path fill="none" stroke="black" d="M9763.14,-8162.65C9760.41,-8111.63 9752.86,-7970.48 9749.58,-7909.26"/>
1096
+ <polygon fill="black" stroke="black" points="9753.07,-7908.93 9749.04,-7899.13 9746.08,-7909.3 9753.07,-7908.93"/>
1097
+ </g>
1098
+ <!-- 95&#45;&gt;39 -->
1099
+ <g id="edge144" class="edge"><title>95&#45;&gt;39</title>
1100
+ <path fill="none" stroke="black" d="M9746.66,-7861.46C9742.94,-7810.44 9732.64,-7669.32 9728.17,-7608.11"/>
1101
+ <polygon fill="black" stroke="black" points="9731.65,-7607.7 9727.43,-7597.98 9724.67,-7608.21 9731.65,-7607.7"/>
1102
+ </g>
1103
+ <!-- 95&#45;&gt;89 -->
1104
+ <g id="edge250" class="edge"><title>95&#45;&gt;89</title>
1105
+ <path fill="none" stroke="black" d="M9713.56,-7862.33C9665.17,-7837.11 9577.09,-7791.2 9524.06,-7763.57"/>
1106
+ <polygon fill="black" stroke="black" points="9525.39,-7760.31 9514.91,-7758.79 9522.16,-7766.52 9525.39,-7760.31"/>
1107
+ </g>
1108
+ <!-- 96&#45;&gt;98 -->
1109
+ <g id="edge256" class="edge"><title>96&#45;&gt;98</title>
1110
+ <path fill="none" stroke="black" d="M8508.84,-5861.65C8516.62,-5915.42 8538.94,-6069.85 8546.72,-6123.62"/>
1111
+ </g>
1112
+ <!-- 99&#45;&gt;27 -->
1113
+ <g id="edge104" class="edge"><title>99&#45;&gt;27</title>
1114
+ <path fill="none" stroke="black" d="M6068.87,-3348.95C6020.84,-3324.41 5934.56,-3280.32 5882.17,-3253.55"/>
1115
+ <polygon fill="black" stroke="black" points="5883.61,-3250.35 5873.11,-3248.92 5880.43,-3256.58 5883.61,-3250.35"/>
1116
+ </g>
1117
+ </g>
1118
+ </svg>