swcgeom 0.14.0__py3-none-any.whl → 0.16.0__py3-none-any.whl

swcgeom/analysis/lmeasure.py

@@ -0,0 +1,821 @@
+"""L-Measure analysis."""
+
+import math
+from typing import Literal, Tuple
+
+import numpy as np
+import numpy.typing as npt
+
+from swcgeom.core import Branch, Compartment, Node, Tree
+from swcgeom.utils import angle
+
+__all__ = ["LMeasure"]
+
+
+class LMeasure:
+    """L-Measure analysis.
+
+    The L-Measure analysis provide a set of morphometric features for
+    multiple levels analysis, as described in the paper [1]_
+
+    References
+    ----------
+    .. [1] Scorcioni R, Polavaram S, Ascoli GA. L-Measure: a
+       web-accessible tool for the analysis, comparison and search of
+       digital reconstructions of neuronal morphologies. Nat Protoc.
+       2008;3(5):866-76. doi: 10.1038/nprot.2008.51. PMID: 18451794;
+       PMCID: PMC4340709.
+
+    See Also
+    --------
+    L-Measure: http://cng.gmu.edu:8080/Lm/help/index.htm
+    """
+
+    def __init__(self, compartment_point: Literal[0, -1] = -1):
+        """
+        Parameters
+        ----------
+        compartment_point : 0 | -1, default=-1
+            The point of the compartment to be used for the measurements.
+            If 0, the first point of the compartment is used. If -1, the
+            last point of the compartment is used.
+        """
+        super().__init__()
+        self.compartment_point = compartment_point
+
+    # Topological measurements
+
+    def n_stems(self, tree: Tree) -> int:
+        """Number of stems that is connected to soma.
+
+        This function returns the number of stems attached to the soma.
+        When the type of the Compartment changes from type=1 to others
+        it is labeled a stem. These stems can also be considered as
+        independent subtrees for subtree level analysis.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/N_stems.htm
+        """
+        return len(tree.soma().children())
+
+    def n_bifs(self, tree: Tree) -> int:
+        """Number of bifurcations.
+
+        This function returns the number of bifurcations for the given
+        input neuron. A bifurcation point has two daughters.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/N_bifs.htm
+        """
+        return len(tree.get_bifurcations())
+
+    def n_branch(self, tree: Tree) -> int:
+        """Number of branches.
+
+        This function returns the number of branches in the given input
+        neuron. A branch is one or more compartments that lie between
+        two branching points or between one branching point and a
+        termination point.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/N_branch.htm
+        """
+        return len(tree.get_branches())
+
+    def n_tips(self, tree: Tree) -> int:
+        """Number of terminal tips.
+
+        This function returns the number of terminal tips for the given
+        input neuron. This function counts the number of compartments
+        that terminate as terminal endpoints.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/N_tips.htm
+        """
+        return len(tree.get_tips())
+
+    def terminal_segment(self) -> int:
+        """Terminal Segment.
+
+        TerminalSegment is the branch that ends as a terminal branch.
+        This function returns "1" for all the compartments in the
+        terminal branch.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/TerminalSegment.htm
+        """
+        raise NotImplementedError()
+
+    def branch_pathlength(self, branch: Branch) -> float:
+        """Length of the branch.
+
+        This function returns the sum of the length of all compartments
+        forming the giveN_branch.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Branch_pathlength.htm
+        """
+        # ? as a topological measurement, this should accept a tree
+        return branch.length()
+
+    def contraction(self, branch: Branch) -> float:
+        """Contraction of the branch.
+
+        This function returns the ratio between Euclidean distance of a
+        branch and its path length.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Contraction.htm
+        """
+        # ? as a topological measurement, this should accept a tree
+        euclidean = branch[0].distance(branch[-1])
+        return euclidean / branch.length()
+
+    def fragmentation(self, branch: Branch) -> int:
+        """Number of compartments.
+
+        This function returns the total number of compartments that
+        constitute a branch between two bifurcation points or between a
+        bifurcation point and a terminal tip.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Fragmentation.htm
+        """
+        # ? as a topological measurement, this should accept a tree
+        return branch.number_of_edges()
+
+    def partition_asymmetry(self, n: Tree.Node) -> float:
+        """Partition asymmetry.
+
+        This is computed only on bifurcation. If n1 is the number of
+        tips on the left and n2 on the right. Asymmetry return
+        abs(n1-n2)/(n1+n2-2).
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Partition_asymmetry.htm
+        """
+        children = n.children()
+        assert (
+            len(children) == 2
+        ), "Partition asymmetry is only defined for bifurcations"
+        n1 = len(children[0].subtree().get_tips())
+        n2 = len(children[1].subtree().get_tips())
+        return abs(n1 - n2) / (n1 + n2 - 2)
+
+    def fractal_dim(self):
+        """Fractal dimension.
+
+        Fractal dimension (D) of neuronal branches is computedas the
+        slope of linear fit of regression line obtained from the
+        log-log plot of Path distance vs Euclidean distance.
+
+        This method of measuring the fractal follows the reference
+        given below by Marks & Burke, J Comp Neurol. 2007. [1]_
+        - When D = 1, the particle moves in a straight line.
+        - When D = 2, the motion is a space-filling random walk
+        - When D is only slightly larger than 1, the particle
+          trajectory resembles a country road or a dendrite branch.
+
+        References
+        ----------
+        .. [1] Marks WB, Burke RE. Simulation of motoneuron morphology
+           in three dimensions. I. Building individual dendritic trees.
+           J Comp Neurol. 2007 Aug 10;503(5):685-700.
+           doi: 10.1002/cne.21418. PMID: 17559104.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Fractal_Dim.htm
+        """
+        raise NotImplementedError()
+
+    # Branch level measurements (thickness and taper)
+
+    def taper_1(self, branch: Branch) -> float:
+        """The Burke Taper.
+
+        This function returns the Burke Taper. This function is
+        measured between two bifurcation points.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Taper_1.htm
+        """
+        da, db = 2 * branch[0].r, 2 * branch[-1].r
+        return (da - db) / branch.length()
+
+    def taper_2(self, branch: Branch) -> float:
+        """The Hillman taper.
+
+        This function returns the Hillman taper. This is measured
+        between two bifurcation points.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Taper_2.htm
+        """
+        da, db = 2 * branch[0].r, 2 * branch[-1].r
+        return (da - db) / da
+
+    def daughter_ratio(self):
+        """Daughter ratio.
+
+        The function returns the ratio between the bigger daughter and
+        the other one. A daughter is the next immediate compartment
+        connected to a bifurcation point.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Daughter_Ratio.htm
+        """
+        raise NotImplementedError()
+
+    def parent_daughter_ratio(self) -> float:
+        """Parent daughter ratio.
+
+        This function returns the ratio between the diameter of a
+        daughter and its father. One values for each daughter is
+        returned at each bifurcation point.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Parent_Daughter_Ratio.htm
+        """
+        raise NotImplementedError()
+
+    def rall_power(self, bif: Tree.Node) -> float:
+        """Rall Power.
+
+        Rall value is computed as the best value that fits the equation
+        (Bif_Dia)^Rall=(Daughter1_dia^Rall+Daughter2_dia^Rall).
+        According to Rall’s rule we compute rall’s power by linking the
+        diameter of two daughter branches to the diameter of the
+        bifurcating parent. We compute the best fit rall’s power within
+        the boundary values of [0, 5] at incremental steps of 1000
+        compartments. The final rall value is the idealistic n value
+        that can propagate the signal transmission without loss from
+        the starting point to the terminal point in a cable model
+        assumption.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Rall_Power.htm
+        """
+
+        rall_power, _, _, _ = self._rall_power(bif)
+        return rall_power
+
+    def _rall_power_d(self, bif: Tree.Node) -> Tuple[float, float, float]:
+        children = bif.children()
+        assert len(children) == 2, "Rall Power is only defined for bifurcations"
+        parent = bif.parent()
+        assert parent is not None, "Rall Power is not defined for root"
+
+        dp = 2 * parent.r
+        da, db = 2 * children[0].r, 2 * children[1].r
+        return dp, da, db
+
+    def _rall_power(self, bif: Tree.Node) -> Tuple[float, float, float, float]:
+        dp, da, db = self._rall_power_d(bif)
+        start, stop, step = 0, 5, 5 / 1000
+        xs = np.arange(start, stop, step)
+        ys = (da**xs + db**xs) - dp**xs
+        return xs[np.argmin(ys)], dp, da, db
+
+    def pk(self, bif: Tree.Node) -> float:
+        """Ratio of rall power increased.
+
+        After computing the average value for Rall_Power, this function
+        returns the ratio of (d1^rall+d2^rall)/(bifurcDiam^rall).
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Pk.htm
+        """
+
+        rall_power, dp, da, db = self._rall_power(bif)
+        return (da**rall_power + db**rall_power) / dp**rall_power
+
+    def pk_classic(self, bif: Tree.Node) -> float:
+        """Ratio of rall power increased with fixed rall power 1.5.
+
+        This function returns the same value as Pk, but with Rall_Power
+        sets to 1.5.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Pk_classic.htm
+        """
+
+        dp, da, db = self._rall_power_d(bif)
+        rall_power = 1.5
+        return (da**rall_power + db**rall_power) / dp**rall_power
+
+    def pk_2(self, bif: Tree.Node) -> float:
+        """Ratio of rall power increased with fixed rall power 2.
+
+        This function returns the same value as Pk, but with Rall_Power
+        sets to 2 .
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Pk_2.htm
+        """
+
+        dp, da, db = self._rall_power_d(bif)
+        rall_power = 2
+        return (da**rall_power + db**rall_power) / dp**rall_power
+
+    def bif_ampl_local(self, bif: Tree.Node) -> float:
+        """Bifuraction angle.
+
+        Given a bifurcation, this function returns the angle between
+        the first two compartments (in degree).
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Bif_ampl_local.htm
+        """
+
+        v1, v2 = self._bif_vector_local(bif)
+        return np.degrees(angle(v1, v2))
+
+    def bif_ampl_remote(self, bif: Tree.Node) -> float:
+        """Bifuraction angle.
+
+        This function returns the angle between two bifurcation points
+        or between bifurcation point and terminal point or between two
+        terminal points.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Bif_ampl_remote.htm
+        """
+
+        v1, v2 = self._bif_vector_local(bif)
+        return np.degrees(angle(v1, v2))
+
+    def bif_tilt_local(self, bif: Tree.Node) -> float:
+        """Bifuarcation tilt.
+
+        This function returns the angle between the previous
+        compartment of bifurcating father and the two daughter
+        compartments of the same bifurcation. The smaller of the two
+        angles is returned as the result.
+
+        Tilt is measured as outer angle between parent and child
+        compartments. L-Measure returns smaller angle of the two
+        children, but intuitively this can be viewed as the angle of
+        deflection of the parent orientation compared to the
+        orientation of the mid line of the bifurcation amplitude angle.
+
+        (i.e.) new tilt(NT) = pi - 1/2 Bif_amp_remote - old tilt(OT)
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Bif_tilt_local.htm
+        """
+
+        parent = bif.parent()
+        assert parent is not None, "Bifurcation tilt is not defined for root"
+        v = parent.xyz() - bif.xyz()
+        v1, v2 = self._bif_vector_local(bif)
+
+        angle1 = np.degrees(angle(v, v1))
+        angle2 = np.degrees(angle(v, v2))
+        return min(angle1, angle2)
+
+    def bif_tilt_remote(self, bif: Tree.Node) -> float:
+        """Bifuarcation tilt.
+
+        This function returns the angle between the previous father
+        node of the current bifurcating father and its two daughter
+        nodes. A node is a terminating point or a bifurcation point or
+        a root point. Smaller of the two angles is returned as the
+        result. This angle is not computed for the root node.
+
+        Tilt is measured as outer angle between parent and child
+        compartments. L-Measure returns smaller angle of the two
+        children, but intuitively this can be viewed as the angle of
+        deflection of the parent orientation compared to the
+        orientation of the mid line of the bifurcation amplitude angle.
+
+        (i.e.) new tilt(NT) = pi - 1/2 Bif_amp_remote - old tilt(OT)
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Bif_tilt_remote.htm
+        """
+
+        parent = bif.parent()
+        assert parent is not None, "Bifurcation tilt is not defined for root"
+        v = parent.xyz() - bif.xyz()
+        v1, v2 = self._bif_vector_remote(bif)
+
+        angle1 = np.degrees(angle(v, v1))
+        angle2 = np.degrees(angle(v, v2))
+        return min(angle1, angle2)
+
+    def bif_torque_local(self, bif: Tree.Node) -> float:
+        """Bifurcation torque.
+
+        This function returns the angle between the plane of previous
+        bifurcation and the current bifurcation. Bifurcation plane is
+        identified by the two daughter compartments leaving the
+        bifurcation.
+
+        A torque is the inner angle measured between two planes
+        (current & parent) of bifurcations. Plane DCE has current
+        bifurcation and plane CAB has parent bifurcation. Although LM
+        returns the absolute angle between CAB and DCE as the result,
+        it must be noted that intuitively what we are measuring is
+        relative change in the angle of second plane (DCE) with respect
+        to the first plane (CAB). Therefore, angles > 90 degrees should
+        be considered as pi - angle.
+
+        i.e. in Example1 tilt = 30deg. and in Example2 tilt = 180-110 = 70deg.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Bif_torque_local.htm
+        """
+
+        parent = bif.parent()
+        assert parent is not None, "Bifurcation torque is not defined for root"
+        idx = parent.branch().origin_id()[0]
+        n = parent.branch().attach.node(idx)
+
+        v1, v2 = self._bif_vector_local(n)
+        u1, u2 = self._bif_vector_local(bif)
+
+        n1, n2 = np.cross(v1, v2), np.cross(u1, u2)
+        theta_deg = np.degrees(angle(n1, n2))
+        raise theta_deg
+
+    def bif_torque_remote(self, bif: Tree.Node) -> float:
+        """Bifurcation torque.
+
+        This function returns the angle between, current plane of
+        bifurcation and previous plane of bifurcation. This is a
+        bifurcation level metric and from the figure, the current
+        plane of bifurcation is formed between C D and E where all
+        three are bifurcation points and the previous plane is formed
+        between A B and C bifurcation points.
+
+        A torque is the inner angle measured between two planes
+        (current & parent) of bifurcations. Plane DCE has current
+        bifurcation and plane CAB has parent bifurcation. Although LM
+        returns the absolute angle between CAB and DCE as the result,
+        it must be noted that intuitively what we are measuring is
+        relative change in the angle of second plane (DCE) with respect
+        to the first plane (CAB). Therefore, angles > 90 degrees should
+        be considered as pi - angle.
+
+        i.e. in Example1 tilt = 30deg. and in Example2 tilt = 180-110 = 70deg.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Bif_torque_remote.htm
+        """
+
+        parent = bif.parent()
+        assert parent is not None, "Bifurcation torque is not defined for root"
+        idx = parent.branch().origin_id()[0]
+        n = parent.branch().attach.node(idx)
+
+        v1, v2 = self._bif_vector_remote(n)
+        u1, u2 = self._bif_vector_remote(bif)
+
+        n1, n2 = np.cross(v1, v2), np.cross(u1, u2)
+        theta_deg = np.degrees(angle(n1, n2))
+        raise theta_deg
+
+    def _bif_vector_local(
+        self, bif: Tree.Node
+    ) -> Tuple[npt.NDArray[np.float32], npt.NDArray[np.float32]]:
+        children = bif.children()
+        assert len(children) == 2, "Only defined for bifurcations"
+
+        v1 = children[0].xyz() - bif.xyz()
+        v2 = children[1].xyz() - bif.xyz()
+        return v1, v2
+
+    def _bif_vector_remote(
+        self, bif: Tree.Node
+    ) -> Tuple[npt.NDArray[np.float32], npt.NDArray[np.float32]]:
+        children = bif.children()
+        assert len(children) == 2, "Only defined for bifurcations"
+
+        v1 = children[0].branch()[-1].xyz() - bif.xyz()
+        v2 = children[1].branch()[-1].xyz() - bif.xyz()
+        return v1, v2
+
+    def last_parent_diam(self, branch: Branch) -> float:
+        """The diameter of last bifurcation before the terminal tips.
+
+        This function returns the diameter of last bifurcation before
+        the terminal tips.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Last_parent_diam.htm
+        """
+
+        raise NotImplementedError()
+
+    def diam_threshold(self, branch: Branch) -> float:
+        """
+
+        This function returns Diameter of first compartment after the
+        last bifurcation leading to a terminal tip.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Diam_threshold.htm
+        """
+
+        raise NotImplementedError()
+
+    def hillman_threshold(self, branch: Branch) -> float:
+        """Hillman Threshold.
+
+        Computes the weighted average between 50% of father and 25% of
+        daughter diameters of the terminal bifurcation.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/HillmanThreshold.htm
+        """
+
+        raise NotImplementedError()
+
+    # Compartment level geometrical measurements
+
+    def diameter(self, node: Node) -> float:
+        """This function returns diameter of each compartment the neuron.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Diameter.htm
+        """
+
+        return 2 * node.r
+
+    def diameter_pow(self, node: Node) -> float:
+        """Computes the diameter raised to the power 1.5 for each compartment.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Diameter_pow.htm
+        """
+
+        return self.diameter(node) ** 1.5
+
+    def length(self, compartment: Compartment) -> float:
+        """Length of the compartment.
+
+        This function returns the length of compartments by computing
+        the distance between the two end points of a compartment.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Length.htm
+        """
+        return compartment.length()
+
+    def surface(self, compartment: Compartment) -> float:
+        """This function returns surface of the compartment.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Surface.htm
+        """
+        p = compartment[self.compartment_point]
+        return cylinder_side_surface_area(p.r, compartment.length())
+
+    def section_area(self, node: Node) -> float:
+        """This function returns the SectionArea of the compartment.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/SectionArea.htm
+        """
+        return circle_area(node.r)
+
+    def volume(self, compartment: Compartment) -> float:
+        """This function returns the volume of the compartment.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Volume.htm
+        """
+        p = compartment[self.compartment_point]
+        return cylinder_volume(p.r, compartment.length())
+
+    def euc_distance(self, node: Tree.Node) -> float:
+        """Euclidean distance from compartment to soma.
+
+        This function returns the Euclidean distance of a compartment
+        with respect to soma.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/EucDistance.htm
+        """
+
+        soma = node.attach.soma()
+        return node.distance(soma)
+
+    def path_distance(self, node: Tree.Node) -> float:
+        """Path distance from compartment to soma.
+
+        This function returns the PathDistance of a compartment.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/PathDistance.htm
+        """
+
+        n = node
+        length = 0
+        while (parent := n.parent()) is not None:
+            length += n.distance(parent)
+            n = parent
+        return length
+
+    def branch_order(self, node: Tree.Node) -> int:
+        """The order of the compartment.
+
+        This function returns the order of the branch with respect to soma.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Branch_Order.htm
+        """
+
+        n = node
+        order = 0
+        while n is not None:
+            if n.is_bifurcation():
+                order += 1
+            n = n.parent()
+        return order
+
+    def terminal_degree(self, node: Tree.Node) -> int:
+        """The number of tips of the comparment.
+
+        This function gives the total number of tips that each
+        compartment will terminate into.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Terminal_degree.htm
+        """
+
+        return len(node.subtree().get_tips())
+
+    def helix(self, compartment: Tree.Compartment) -> float:
+        """Helix of the compartment.
+
+        The function computes the helix by choosing the 3 segments at a
+        time (or four points at a time) and computes the normal form on
+        the 3 vectors to find the 4th vector.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Helix.htm
+        """
+
+        n1 = compartment.attach.node(compartment.origin_id()[0])
+        n2 = compartment.attach.node(compartment.origin_id()[1])
+        parent = n1.parent()
+        assert parent is not None
+        grandparent = parent.parent()
+        assert grandparent is not None
+
+        a = n1.xyz() - parent.xyz()
+        b = parent.xyz() - grandparent.xyz()
+        c = n2.xyz() - n1.xyz()
+        return np.dot(np.cross(a, b), c) / (
+            3 * np.linalg.norm(a) * np.linalg.norm(b) * np.linalg.norm(c)
+        )
+
+    # Whole-arbor measurements
+
+    def width(self, tree: Tree) -> float:
+        """With of the neuron.
+
+        Width is computed on the x-coordinates and it is the difference
+        of minimum and maximum x-values after eliminating the outer
+        points on the either ends by using the 95% approximation of the
+        x-values of the given input neuron.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Width.htm
+        """
+        return max_filtered_difference(tree.x(), 95)
+
+    def height(self, tree: Tree) -> float:
+        """Height of the neuron.
+
+        Height is computed on the y-coordinates and it is the
+        difference of minimum and maximum y-values after eliminating
+        the outer points on the either ends by using the 95%
+        approximation of the y-values of the given input neuron.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Height.htm
+        """
+        return max_filtered_difference(tree.y(), 95)
+
+    def depth(self, tree: Tree) -> float:
+        """Depth of the neuron.
+
+        Depth is computed on the x-coordinates and it is the difference
+        of minimum and maximum x-values after eliminating the outer
+        points on the either ends by using the 95% approximation of the
+        x-values of the given input neuron.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Depth.htm
+        """
+        return max_filtered_difference(tree.z(), 95)
+
+    # Specific-arbor type measurements
+
+    def soma_surface(self, tree: Tree) -> float:
+        """Soma surface area.
+
+        This function computes the surface of the soma (Type=1). If the
+        soma is composed of just one compartment, then it uses the
+        sphere assumption, otherwise it returns the sum of the external
+        cylindrical surfaces of compartments forming the soma. There
+        can be multiple soma's, one soma or no soma at all.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Soma_Surface.htm
+        """
+        return sphere_surface_area(tree.soma().r)  # TODO: handle multiple soma
+
+    def type(self):
+        """The type of compartment.
+
+        This function returns type of compartment. Each compartment of
+        the neuron is of a particular type; soma = 1, axon = 2, basal
+        dendrites = 3, apical dendrites= 4. The type values are
+        assigned directly from the given input neuron.
+
+        See Also
+        --------
+        L-Measure: http://cng.gmu.edu:8080/Lm/help/Type.htm
+        """
+        raise NotImplementedError()
+
+
+def max_filtered_difference(
+    values: npt.NDArray[np.float32], percentile: float = 95
+) -> float:
+    assert 0 < percentile < 100, "Percentile must be between 0 and 100"
+    sorted = np.sort(values)
+    lower_index = int(len(sorted) * (100 - percentile) / 200)
+    upper_index = int(len(sorted) * (1 - (100 - percentile) / 200))
+    filtered = sorted[lower_index:upper_index]
+    difference = filtered[-1] - filtered[0]
+    return difference
+
+
+def circle_area(r: float) -> float:
+    return math.pi * r**2
+
+
+def sphere_surface_area(r: float):
+    return 4 * math.pi * r**2
+
+
+def cylinder_volume(r: float, h: float) -> float:
+    return math.pi * r**2 * h
+
+
+def cylinder_side_surface_area(r: float, h: float):
+    return 2 * math.pi * r * h
+
+
+def pill_surface_area(ra: float, rb: float, h: float) -> float:
+    lateral_area = math.pi * (ra + rb) * math.sqrt((ra - rb) ** 2 + h**2)
+    top_hemisphere_area = 2 * math.pi * ra**2
+    bottom_hemisphere_area = 2 * math.pi * rb**2
+    total_area = lateral_area + top_hemisphere_area + bottom_hemisphere_area
+    return total_area