rwe 0.0.2__py3-none-any.whl → 0.0.4__py3-none-any.whl

rwe/clients/aou.py

@@ -34,13 +34,13 @@ def generate_aou_variant_info_demographics_report(doc: Document, chrm: str, gene
     fig1_path = uth._save_fig_to_tmp(fig1, basename="variant_information", dpi=300)
     doc.add_paragraph()  # spacing
     doc.add_picture(fig1_path, width=Inches(6.5))
-    uth._add_caption(doc, "Figure 1. Variant information summary (carrier counts by consequence; most/least frequent variants).")
+    uth._add_figure_caption(doc, "Variant information summary (carrier counts by consequence; most/least frequent variants).")
     # 2) Demographics figure
     fig2, _axes2 = demographics_plot(person_df)
     fig2_path = uth._save_fig_to_tmp(fig2, basename="demographics", dpi=300)
     doc.add_paragraph()  # spacing
-    doc.add_picture(fig2_path, width=Inches(6.5))
-    uth._add_caption(doc, "Figure 2. Demographics of cases vs controls (age, ancestry, sex at birth, ethnicity).")
+    doc.add_picture(fig2_path, width=Inches(4))
+    uth._add_figure_caption(doc, "Demographics of cases vs controls (age, ancestry, sex at birth, ethnicity).")
     return doc
 
 
@@ -75,38 +75,39 @@ def get_aou_manhattan(df, gene):
 def generate_aou_clinical_report(doc, chrm, gene, zygosity):
     from rwe.parsers.aou.config import BUCKET
     phewas_file = f"{BUCKET}/data/phewas/results/chr{chrm}/{gene}_phewas.csv"
+    doc.add_heading("Phenome-wide Association Study (PheWAS) in All of Us cohort", level=2)
     if uth._gcs_size(phewas_file, BUCKET) > 0: 
         df = clean_aou_phewas(phewas_file)
         fig, plot_df = get_aou_manhattan(df, gene)
         fig_path = uth._save_fig_to_tmp(fig, basename="aou_phewas", dpi=300)
         doc.add_paragraph()  # spacing
         doc.add_picture(fig_path, width=Inches(6.5))
-        uth._add_caption(doc, f"Figure X. {gene} PheWAS results from All of Us.")
+        uth._add_figure_caption(doc, f"{gene} PheWAS results from All of Us.")
         doc.add_paragraph()  # spacing
 
-        # Table 1: Top 10 significant hits (sorted by p-value)
+        # Table: Top 10 significant hits (sorted by p-value)
         top_significant = plot_df.nsmallest(10, 'p_value')
         columns = ['phecode_string', 'phecode_category', 'odds_ratio', 'p_value']
         # Rename columns for display
         display_df = top_significant[columns].copy()
         display_df.columns = ['Phecode', 'Category', 'OR', 'P-value']
-        uth._add_table_to_doc(doc, display_df, f"Table X. Top 10 significant associations for {gene}",
+        uth._add_table_to_doc(doc, display_df, uth._add_table_title(doc, f"Top 10 significant associations for {gene} in AoU"),
                         ['Phecode', 'Category', 'OR', 'P-value'], list(map(Inches, [2.75, 1.75, 0.75, 0.75]))
                         )
 
-        # Table 2: Top 10 negative beta hits (odds_ratio < 0, sorted by p-value)
+        # Table: Top 10 negative beta hits (odds_ratio < 0, sorted by p-value)
         negative_beta = plot_df[plot_df['odds_ratio'] < 1].nsmallest(10, 'p_value')
         if len(negative_beta) > 0:
             display_df_neg = negative_beta[columns].copy()
             display_df_neg.columns = ['Phecode', 'Category', 'OR', 'P-value']
-            uth._add_table_to_doc(doc, display_df_neg, f"Table X. Top 10 protective associations for {gene}",
+            uth._add_table_to_doc(doc, display_df_neg, uth._add_table_title(doc, f"Top 10 protective associations for {gene} in AoU"),
                             ['Phecode', 'Category', 'OR', 'P-value'], list(map(Inches, [2.75, 1.75, 0.75, 0.75]))
                             )
 
-        doc.add_paragraph()  # spacing
+        doc.add_page_break()  # spacing
     else:
         doc.add_paragraph(f"No AoU PheWAS results found for {gene}.")
-        doc.add_paragraph()  # spacing
+        doc.add_page_break()  # spacing
     return doc
 
 
@@ -160,14 +161,22 @@ def generate_aou_labs_measurements_report(doc: Document, chrm: str, gene: str, z
     numerical_measurements_df["cases"] = numerical_measurements_df.person_id.isin(variant_df[f"{zygosity}_samples"])
     measurements = numerical_measurements_df["measurement"].unique().tolist()
     res_df = run_parallel(numerical_measurements_df, measurements=measurements, n_jobs=None, chunksize=20)
-    # TODO: add most significant measurements table to doc
+    top_ten_lab = res_df.nsmallest(10, "p_mwu").loc[:, ["measurement", "p_mwu", "u_stat", "n_cases", "n_ctrls"]]
+    top_ten_lab.columns = ["Measurement", "P-value", "U statistic", "N cases", "N controls"]
+    uth._add_table_to_doc(
+        doc, top_ten_lab, uth._add_table_title(
+            doc, f"Top 10 lab measurements for {gene} pLoF carriers in AoU"), 
+            top_ten_lab.columns.tolist(), list(map(Inches, [3, 0.75, 0.75, 0.75, 0.75]))
+    )
+    doc.add_page_break()  # spacing
     for k,v in MEASUREMENT_GROUPS.items():
-        f, a = plot_measurements(numerical_measurements_df, v, multiplier=5, col="median_value", res_df=res_df)
+        f, a = plot_measurements(numerical_measurements_df, v, col="median_value", res_df=res_df)
         fig_path = uth._save_fig_to_tmp(f, basename=f"aou_measurements_{k}", dpi=300)
         doc.add_paragraph()  # spacing
+        doc.add_heading(f"{k.capitalize} profile of {gene} pLoF carriers in All of Us cohort", level=2)
         doc.add_picture(fig_path, width=Inches(6.5))
-        uth._add_caption(doc, f"Figure X. {gene} pLoF carrier {k} results from All of Us.")
-        doc.add_paragraph()  # spacing
+        uth._add_figure_caption(doc, f"{gene} pLoF carrier {k} results from All of Us.")
+        doc.add_page_break()  # spacing
     return doc
 
 ############### Surveys ###############
@@ -187,7 +196,7 @@ def generate_aou_survey_report(doc: Document, chrm: str, gene: str, zygosity: st
     fig_path = uth._save_fig_to_tmp(fig, basename="aou_surveys", dpi=300)
     doc.add_paragraph()  # spacing
     doc.add_picture(fig_path, width=Inches(6.5))
-    uth._add_caption(doc, f"Figure X. {gene} pLoF carrier survey results from All of Us.")
+    uth._add_figure_caption(doc, f"{gene} pLoF carrier survey results from All of Us.")
     doc.add_paragraph()  # spacing
     return doc
 

rwe/clients/azn.py

@@ -10,41 +10,34 @@ import rwe.utils.helpers as uth
 from docx.shared import Inches
 
 def extract_only_csv_rename(zip_path: str, gene: str) -> str:
-    """
-    Unzips `zip_path` into its parent directory, keeps only the csv,
-    renames it to {gene}_azphewas.csv, removes everything else including the zip.
-    Returns final csv path.
-    """
     zip_path = Path(zip_path)
     gene_dir = zip_path.parent
     target_csv = gene_dir / f"{gene}_azphewas.csv"
 
-    # Extract zip into gene_dir
+    # Extract into a dedicated folder
+    extract_dir = gene_dir / f"__extract_{zip_path.stem}"
+    if extract_dir.exists():
+        shutil.rmtree(extract_dir)
+    extract_dir.mkdir(parents=True, exist_ok=True)
+
     with zipfile.ZipFile(zip_path, "r") as z:
-        z.extractall(gene_dir)
+        z.extractall(extract_dir)
 
-    # Find CSV(s) extracted
-    csvs = list(gene_dir.rglob("*.csv"))
+    csvs = list(extract_dir.rglob("*.csv"))
     if not csvs:
         raise FileNotFoundError(f"No CSV found after extracting {zip_path}")
 
-    # If multiple CSVs, pick the largest (usually the main table export)
     csvs.sort(key=lambda p: p.stat().st_size, reverse=True)
     chosen = csvs[0]
 
-    # Move/rename chosen CSV to target name at gene_dir root
     if target_csv.exists():
         target_csv.unlink()
     chosen.replace(target_csv)
 
-    # Cleanup: remove everything except the renamed CSV
-    for p in gene_dir.iterdir():
-        if p == target_csv:
-            continue
-        if p.is_dir():
-            shutil.rmtree(p)
-        else:
-            p.unlink()
+    # Cleanup only what we created
+    shutil.rmtree(extract_dir)
+    if zip_path.exists():
+        zip_path.unlink()
 
     return str(target_csv)
 
@@ -143,36 +136,37 @@ def generate_azn_clinical_report(doc, gene, phewas_dir, phewas_filename=""):
         with sync_playwright() as playwright:
             run(playwright, gene=gene, save_path=phewas_dir)
 
-    if os.path.exists(phewas_file): 
+    doc.add_heading("Phenome-wide Association Study (PheWAS) in UK Biobank cohort collected from AstraZeneca", level=2)
+    if os.path.exists(phewas_file):
         fig, plot_df = get_azn_manhattan(gene, phewas_file)
         fig_path = uth._save_fig_to_tmp(fig, basename="azn_phewas", dpi=300)
         doc.add_paragraph()  # spacing
         doc.add_picture(fig_path, width=Inches(6.5))
-        uth._add_caption(doc, f"Figure X. {gene} PheWAS results from AstraZeneca.")
+        uth._add_figure_caption(doc, f"{gene} PheWAS results from AstraZeneca.")
         doc.add_paragraph()  # spacing
 
-        # Table 1: Top 10 significant hits (sorted by p-value)
+        # Table: Top 10 significant hits (sorted by p-value)
         top_significant = plot_df.nsmallest(10, 'P value')
         columns = ['Phenotype', 'Phenotypic category', 'Odds ratio', 'P value']
         # Rename columns for display
         display_df = top_significant[columns].copy()
         display_df.columns = ['Phenotype', 'Category', 'OR', 'P-value']
-        uth._add_table_to_doc(doc, display_df, f"Table X. Top 10 significant associations for {gene}",
+        uth._add_table_to_doc(doc, display_df, uth._add_table_title(doc, f"Top 10 significant associations for {gene} in AstraZeneca"),
                         ['Phenotype', 'Category', 'OR', 'P-value'], list(map(Inches, [2.75, 1.75, 0.75, 0.75]))
                         )
-        # Table 2: Top 10 negative beta hits (odds_ratio < 0, sorted by p-value)
+        # Table: Top 10 negative beta hits (odds_ratio < 0, sorted by p-value)
         negative_beta = plot_df[plot_df['Odds ratio'] < 1].nsmallest(10, 'P value')
         if len(negative_beta) > 0:
             display_df_neg = negative_beta[columns].copy()
             display_df_neg.columns = ['Phenotype', 'Category', 'OR', 'P-value']
-            uth._add_table_to_doc(doc, display_df_neg, f"Table X. Top 10 protective associations for {gene}",
+            uth._add_table_to_doc(doc, display_df_neg, uth._add_table_title(doc, f"Top 10 protective associations for {gene} in AstraZeneca"),
                             ['Phenotype', 'Category', 'OR', 'P-value'], list(map(Inches, [2.75, 1.75, 0.75, 0.75]))
                             )
-        doc.add_paragraph()  # spacing
+        doc.add_page_break()  # spacing
 
     else:
         doc.add_paragraph(f"No AstraZeneca PheWAS results found for {gene}.")
-        doc.add_paragraph()  # spacing
+        doc.add_page_break()  # spacing
     return doc
 
 

rwe/clients/genebass.py

@@ -93,38 +93,38 @@ def generate_genebass_clinical_report(doc, gene, phewas_dir, phewas_filename="")
         approved_symbol, ensembl_id, entrez_id = get_gene_info(gene, hgnc_path)
         with sync_playwright() as playwright:
             run(playwright, approved_symbol, ensembl_id, save_path=phewas_dir)
-
+    doc.add_heading("Phenome-wide Association Study (PheWAS) in UK Biobank cohort collected from GeneBass", level=2)
     if os.path.exists(phewas_file):
         fig, plot_df = get_genebass_manhattan(gene, phewas_file)
         fig_path = uth._save_fig_to_tmp(fig, basename="genebass_phewas", dpi=300)
         doc.add_paragraph()  # spacing
         doc.add_picture(fig_path, width=Inches(6))
-        uth._add_caption(doc, f"Figure X. {gene} PheWAS results from GeneBass.")
+        uth._add_figure_caption(doc, f"{gene} PheWAS results from GeneBass.")
         doc.add_paragraph()  # spacing
 
-        # Table 1: Top 10 significant hits (sorted by p-value)
+        # Table: Top 10 significant hits (sorted by p-value)
         top_significant = plot_df.nsmallest(10, 'P-Value (Burden)')
         columns = ['Description', 'Category', 'Beta', 'P-Value (Burden)']
         # Rename columns for display
         display_df = top_significant[columns].copy()
         display_df.columns = ['Description', 'Category', 'Beta', 'P-value']
-        uth._add_table_to_doc(doc, display_df, f"Table X. Top 10 significant associations for {gene}",
+        uth._add_table_to_doc(doc, display_df, uth._add_table_title(doc, f"Top 10 significant associations for {gene} in GeneBass"),
                         ['Description', 'Category', 'Beta', 'P-value'], list(map(Inches, [2.75, 2.0, 0.5, 0.75]))
                         )
 
-        # Table 2: Top 10 negative beta hits (beta < 0, sorted by p-value)
+        # Table: Top 10 negative beta hits (beta < 0, sorted by p-value)
         negative_beta = plot_df[plot_df['Beta'] < 0].nsmallest(10, 'P-Value (Burden)')
         if len(negative_beta) > 0:
             display_df_neg = negative_beta[columns].copy()
             display_df_neg.columns = ['Description', 'Category', 'Beta', 'P-value']
-            uth._add_table_to_doc(doc, display_df_neg, f"Table X. Top 10 protective associations for {gene}",
+            uth._add_table_to_doc(doc, display_df_neg, uth._add_table_title(doc, f"Top 10 protective associations for {gene} in GeneBass"),
                             ['Description', 'Category', 'Beta', 'P-value'], list(map(Inches, [2.75, 2.0, 0.5, 0.75]))
                             )
             
-        doc.add_paragraph()  # spacing
+        doc.add_page_break()  # spacing
     else:
         doc.add_paragraph(f"No GeneBass PheWAS results found for {gene}.")
-        doc.add_paragraph()  # spacing
+        doc.add_page_break()  # spacing
     return doc
 
 if __name__ == "__main__":

rwe/generate_report.py

@@ -33,7 +33,9 @@ def generate_rwe_report(
     logo_path : optional str (path to Arrowhead logo PNG/JPG)
     report_date : optional str (e.g. "January 26th, 2026")
     """
-    proj_dir = os.path.dirname(out_docx_path) or "."
+    if not out_docx_path:
+        out_docx_path = f"./rwe_reports/{gene}_RWE_report.docx"
+    proj_dir = os.path.dirname(out_docx_path)
     os.makedirs(proj_dir, exist_ok=True)
 
     # --- Title and Contents --- #
@@ -56,8 +58,6 @@ def generate_rwe_report(
 
 
     # Save
-    if not out_docx_path:
-        out_docx_path = f"{gene}_RWE_report.docx"
     doc.save(out_docx_path)
     return out_docx_path
 

rwe/parsers/aou/config.py

@@ -61,7 +61,7 @@ PLAUSIBLE = {
 
     # --- Liver / protein balance (AoU typical units: albumin g/L, protein g/L, enzymes U/L, bilirubin mg/dL OR umol/L; range is loose) ---
     "Albumin [Mass/volume] in Serum or Plasma": (15, 60),                   # g/L
-    "Protein [Mass/volume] in Serum or Plasma": (40, 100),                  # g/L
+    "Protein [Mass/volume] in Serum or Plasma": (3, 12),                  # g/dL
     "Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma": (0, 1000),     # U/L
     "Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma": (0, 1000),   # U/L
     "Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma": (10, 2000),        # U/L

rwe/utils/helpers.py

@@ -10,6 +10,28 @@ from google.cloud import storage
 
 # ---------- DOCX helpers ----------
 
+def _init_report_counters(doc: Document) -> Document:
+    """Initialize figure and table counters on the document object."""
+    doc._report_counters = {"figure": 0, "table": 0}
+    return doc
+
+
+def _get_next_figure_num(doc: Document) -> int:
+    """Get the next figure number and increment the counter."""
+    if not hasattr(doc, '_report_counters'):
+        doc._report_counters = {"figure": 0, "table": 0}
+    doc._report_counters["figure"] += 1
+    return doc._report_counters["figure"]
+
+
+def _get_next_table_num(doc: Document) -> int:
+    """Get the next table number and increment the counter."""
+    if not hasattr(doc, '_report_counters'):
+        doc._report_counters = {"figure": 0, "table": 0}
+    doc._report_counters["table"] += 1
+    return doc._report_counters["table"]
+
+
 def _set_default_styles(doc: Document):
     # Normal
     style = doc.styles["Normal"]
@@ -57,12 +79,39 @@ def _add_toc_field(paragraph):
 
 
 def _add_caption(doc: Document, text: str):
+    """Add a caption paragraph (for backward compatibility)."""
     p = doc.add_paragraph(text)
     p.style = doc.styles["Normal"]
     p.runs[0].italic = True
     p.alignment = WD_ALIGN_PARAGRAPH.CENTER
     return p
 
+
+def _add_figure_caption(doc: Document, description: str):
+    """Add an auto-numbered figure caption.
+
+    Args:
+        doc: Document object with _report_counters attached
+        description: Caption text without the "Figure X." prefix
+    """
+    fig_num = _get_next_figure_num(doc)
+    text = f"Figure {fig_num}. {description}"
+    return _add_caption(doc, text)
+
+
+def _add_table_title(doc: Document, description: str):
+    """Get an auto-numbered table title string.
+
+    Args:
+        doc: Document object with _report_counters attached
+        description: Title text without the "Table X." prefix
+
+    Returns:
+        str: The full table title with number prefix
+    """
+    table_num = _get_next_table_num(doc)
+    return f"Table {table_num}. {description}"
+
 def _save_fig_to_tmp(fig, basename="figure", dpi=300):
     tmpdir = tempfile.mkdtemp(prefix="rwe_report_")
     path = os.path.join(tmpdir, f"{basename}.png")

rwe/utils/report.py

@@ -41,6 +41,7 @@ def generate_title_and_contents(gene: str, logo_path: str | None = None, report_
 
     doc = Document()
     uth._set_default_styles(doc)
+    uth._init_report_counters(doc)
 
     # --- Title page ---
     if logo_path and os.path.exists(logo_path):

{rwe-0.0.2.dist-info → rwe-0.0.4.dist-info}/METADATA

@@ -1,6 +1,6 @@
 Metadata-Version: 2.4
 Name: rwe
-Version: 0.0.2
+Version: 0.0.4
 Summary: Real World Evidence utilities and reporting
 Author: Deepro Banerjee
 License: MIT License

{rwe-0.0.2.dist-info → rwe-0.0.4.dist-info}/RECORD

@@ -1,15 +1,15 @@
 rwe/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
-rwe/generate_report.py,sha256=-NbQJ4H-NYdDzziWMoi5PUWyhZ7p8iVC8UXYUP1v_xY,1833
+rwe/generate_report.py,sha256=AlM-_RzLAPYoM8U120qdQH1E9TmqzJkkBZpHXlAH7Yw,1840
 rwe/assets/Arrowhead_Pharmaceuticals_logo.png,sha256=C2mAn6GG4gArds4sBnqM5LcxhuZgujXjwGiZxIuxbLo,51053
 rwe/clients/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
-rwe/clients/aou.py,sha256=vhjoUZAVZUl5K_mSJLYg3x8OvNi4gAMdwWEYXlycR9k,9401
-rwe/clients/azn.py,sha256=6zwEv0IAgBA-FcI2glGerA9M6pzdKQx7M5M4HZI8HQs,7541
-rwe/clients/genebass.py,sha256=OkF0_J4lmiujWlffsBlAM3uKxKOCzi7_3f_ehju_tPE,6103
+rwe/clients/aou.py,sha256=YHp1QbUXBAHR6OrngggOj6-NVsnJ7x5-K1Da7UnZbVY,10047
+rwe/clients/azn.py,sha256=eQ3WKepK5xNk9JVaXNACTJNsbW2DXWHqermVV51YcOM,7441
+rwe/clients/genebass.py,sha256=HzaKCkNBubf0-qCx1g_DcR4baSqsM0OfSmKoupV7RPs,6274
 rwe/clients/hgnc.py,sha256=ZabNiMgzwu4rCVCptbgUb38qHsL9cHlsQX7s6mZA8Nk,2015
 rwe/parsers/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
 rwe/parsers/aou/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
 rwe/parsers/aou/collect.py,sha256=3j9S0vg3s5u-lJYhP9gdJA_SJVUTUld-i8M1mS-qg-0,13610
-rwe/parsers/aou/config.py,sha256=_BdQohVgSeLNIkoLBQ4XIgo2ucep6NDU8k0vGKgONj8,27018
+rwe/parsers/aou/config.py,sha256=7O8NhrxOAeDJnKYsiQBgufNkxo_O6nRPSrhJ49pteLk,27017
 rwe/parsers/aou/process.py,sha256=q-H12OQdwBZMqWxuDo389m6WCJb9Qsp5ZIwVc2MHqu4,3683
 rwe/plots/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
 rwe/plots/clinical.py,sha256=dBgdrFog-4gWJyJphoObSuoPtS7Q4wOprWyXMcDD6Dw,7738
@@ -18,10 +18,10 @@ rwe/plots/measurements.py,sha256=Z7GG4SMXD3ExGGJF6LvmZ_XwvMwGB_6FFk7nxz_8fr8,328
 rwe/plots/surveys.py,sha256=2SiNBnjLQL2V4jfeMTIj2y2v7y7Wh4kLji2dnEJ0cdo,6672
 rwe/plots/variant_info.py,sha256=KLUnefwmSxcmOn7mkNBcxvJdpNN4i4F9SZ0SZGlNrvk,5362
 rwe/utils/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
-rwe/utils/helpers.py,sha256=t3fmx2OsFx3fvg2uZggagm5LS-PE7J3Yr7Ew3VJUsnA,4336
-rwe/utils/report.py,sha256=Vyfle1aOoCkqtVeBHAzCdb6hgR0sQZn_qQ4szUw_A3w,4658
-rwe-0.0.2.dist-info/licenses/LICENSE,sha256=0PfJPAoyFVWY4L80aEcQyjy4PojxzfqcOenSuXdhgBg,1072
-rwe-0.0.2.dist-info/METADATA,sha256=1lz1eESuIy78YTClKI8Kug_f7AKq57QWDxfYSKjGfcs,23601
-rwe-0.0.2.dist-info/WHEEL,sha256=wUyA8OaulRlbfwMtmQsvNngGrxQHAvkKcvRmdizlJi0,92
-rwe-0.0.2.dist-info/top_level.txt,sha256=zwX0M3dfnEfklZqvvBPQXiJykChpiqt219EolC3WFRc,4
-rwe-0.0.2.dist-info/RECORD,,
+rwe/utils/helpers.py,sha256=4yeNeaK_29t9uZL4sZr9kHtUf5rJ5P6cAuWY4BT-hvk,5957
+rwe/utils/report.py,sha256=dAWWeB1eaO1CD7fn1RbBt4R4dBdl9LyuQe6uPj4TAKI,4693
+rwe-0.0.4.dist-info/licenses/LICENSE,sha256=0PfJPAoyFVWY4L80aEcQyjy4PojxzfqcOenSuXdhgBg,1072
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