pertpy 0.9.5__py3-none-any.whl → 0.11.0__py3-none-any.whl

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (44) hide show
  1. pertpy/__init__.py +5 -1
  2. pertpy/_doc.py +2 -5
  3. pertpy/_types.py +6 -0
  4. pertpy/data/_dataloader.py +68 -24
  5. pertpy/data/_datasets.py +9 -9
  6. pertpy/metadata/__init__.py +2 -1
  7. pertpy/metadata/_cell_line.py +136 -30
  8. pertpy/metadata/_look_up.py +13 -19
  9. pertpy/metadata/_moa.py +1 -1
  10. pertpy/preprocessing/_guide_rna.py +221 -39
  11. pertpy/preprocessing/_guide_rna_mixture.py +177 -0
  12. pertpy/tools/__init__.py +1 -1
  13. pertpy/tools/_augur.py +138 -142
  14. pertpy/tools/_cinemaot.py +75 -117
  15. pertpy/tools/_coda/_base_coda.py +150 -174
  16. pertpy/tools/_coda/_sccoda.py +66 -69
  17. pertpy/tools/_coda/_tasccoda.py +71 -79
  18. pertpy/tools/_dialogue.py +60 -56
  19. pertpy/tools/_differential_gene_expression/_base.py +25 -43
  20. pertpy/tools/_differential_gene_expression/_checks.py +4 -6
  21. pertpy/tools/_differential_gene_expression/_dge_comparison.py +5 -6
  22. pertpy/tools/_differential_gene_expression/_edger.py +6 -10
  23. pertpy/tools/_differential_gene_expression/_pydeseq2.py +1 -1
  24. pertpy/tools/_differential_gene_expression/_simple_tests.py +3 -3
  25. pertpy/tools/_differential_gene_expression/_statsmodels.py +8 -5
  26. pertpy/tools/_distances/_distance_tests.py +1 -2
  27. pertpy/tools/_distances/_distances.py +86 -92
  28. pertpy/tools/_enrichment.py +8 -25
  29. pertpy/tools/_milo.py +23 -27
  30. pertpy/tools/_mixscape.py +261 -175
  31. pertpy/tools/_perturbation_space/_clustering.py +4 -4
  32. pertpy/tools/_perturbation_space/_comparison.py +4 -4
  33. pertpy/tools/_perturbation_space/_discriminator_classifiers.py +83 -32
  34. pertpy/tools/_perturbation_space/_perturbation_space.py +10 -10
  35. pertpy/tools/_perturbation_space/_simple.py +13 -17
  36. pertpy/tools/_scgen/_scgen.py +17 -20
  37. pertpy/tools/_scgen/_scgenvae.py +2 -2
  38. pertpy/tools/_scgen/_utils.py +3 -1
  39. {pertpy-0.9.5.dist-info → pertpy-0.11.0.dist-info}/METADATA +37 -21
  40. pertpy-0.11.0.dist-info/RECORD +58 -0
  41. {pertpy-0.9.5.dist-info → pertpy-0.11.0.dist-info}/licenses/LICENSE +1 -0
  42. pertpy/tools/_kernel_pca.py +0 -50
  43. pertpy-0.9.5.dist-info/RECORD +0 -57
  44. {pertpy-0.9.5.dist-info → pertpy-0.11.0.dist-info}/WHEEL +0 -0
@@ -32,7 +32,9 @@ def extractor(
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  train_data = anndata.read("./data/train.h5ad")
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  test_data = anndata.read("./data/test.h5ad")
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- train_data_extracted_list = extractor(train_data, "CD4T", "conditions", "cell_type", "control", "stimulated")
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+ train_data_extracted_list = extractor(
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+ train_data, "CD4T", "conditions", "cell_type", "control", "stimulated"
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+ )
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  """
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  cell_with_both_condition = data[data.obs[cell_type_key] == cell_type]
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  condition_1 = data[(data.obs[cell_type_key] == cell_type) & (data.obs[condition_key] == ctrl_key)]
@@ -1,15 +1,16 @@
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  Metadata-Version: 2.4
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  Name: pertpy
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- Version: 0.9.5
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+ Version: 0.11.0
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  Summary: Perturbation Analysis in the scverse ecosystem.
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  Project-URL: Documentation, https://pertpy.readthedocs.io
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  Project-URL: Source, https://github.com/scverse/pertpy
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  Project-URL: Home-page, https://github.com/scverse/pertpy
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- Author: Lukas Heumos, Yuge Ji, Lilly May, Alejandro Tejada, Johannes Köster, Emma Dann, Xinyue Zhang, Xichen Wu, Tessa Green, Stefan Peidli, Antonia Schumacher, Gregor Sturm
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+ Author: Lukas Heumos, Lilly May, Stefan Peidli, Johannes Ostner, Gregor Sturm, Emma Dann, Yuge Ji, Xinyue Zhang, Xichen Wu, Tessa Green, Antonia Schumacher
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  Maintainer-email: Lukas Heumos <lukas.heumos@posteo.net>
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  License: MIT License
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  Copyright (c) 2021, Lukas Heumos
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+ Copyright (c) 2025, scverse®
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  Permission is hereby granted, free of charge, to any person obtaining a copy
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  of this software and associated documentation files (the "Software"), to deal
@@ -29,7 +30,7 @@ License: MIT License
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  OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
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  SOFTWARE.
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  License-File: LICENSE
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- Classifier: Development Status :: 4 - Beta
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+ Classifier: Development Status :: 5 - Production/Stable
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  Classifier: Environment :: Console
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  Classifier: Framework :: Jupyter
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  Classifier: Intended Audience :: Developers
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  Classifier: Operating System :: MacOS :: MacOS X
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  Classifier: Operating System :: POSIX :: Linux
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  Classifier: Programming Language :: Python :: 3
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- Classifier: Programming Language :: Python :: 3.10
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  Classifier: Programming Language :: Python :: 3.11
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  Classifier: Programming Language :: Python :: 3.12
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+ Classifier: Programming Language :: Python :: 3.13
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  Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
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  Classifier: Topic :: Scientific/Engineering :: Visualization
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- Requires-Python: <3.13,>=3.10
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+ Requires-Python: <3.14,>=3.11
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  Requires-Dist: adjusttext
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+ Requires-Dist: arviz
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  Requires-Dist: blitzgsea
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  Requires-Dist: decoupler
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+ Requires-Dist: fast-array-utils
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  Requires-Dist: lamin-utils
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- Requires-Dist: muon
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+ Requires-Dist: mudata
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  Requires-Dist: openpyxl
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  Requires-Dist: ott-jax
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  Requires-Dist: pubchempy
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  Requires-Dist: pyarrow
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  Requires-Dist: requests
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  Requires-Dist: rich
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- Requires-Dist: scanpy[leiden]
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+ Requires-Dist: scanpy
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+ Requires-Dist: scikit-learn>=1.4
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  Requires-Dist: scikit-misc
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- Requires-Dist: scipy
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  Requires-Dist: scvi-tools
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  Requires-Dist: sparsecca
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- Provides-Extra: coda
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- Requires-Dist: arviz; extra == 'coda'
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- Requires-Dist: ete3; extra == 'coda'
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- Requires-Dist: pyqt5; extra == 'coda'
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- Requires-Dist: toytree; extra == 'coda'
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  Provides-Extra: de
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  Requires-Dist: formulaic; extra == 'de'
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  Requires-Dist: formulaic-contrasts>=0.2.0; extra == 'de'
@@ -73,28 +71,33 @@ Requires-Dist: pydeseq2>=v0.5.0pre1; extra == 'de'
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  Provides-Extra: dev
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  Requires-Dist: pre-commit; extra == 'dev'
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  Provides-Extra: doc
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- Requires-Dist: docutils!=0.18.*,!=0.19.*,>=0.8; extra == 'doc'
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- Requires-Dist: furo; extra == 'doc'
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+ Requires-Dist: docutils>=0.8; extra == 'doc'
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  Requires-Dist: ipykernel; extra == 'doc'
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  Requires-Dist: ipython; extra == 'doc'
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  Requires-Dist: myst-nb; extra == 'doc'
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- Requires-Dist: myst-parser; extra == 'doc'
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  Requires-Dist: nbsphinx; extra == 'doc'
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  Requires-Dist: nbsphinx-link; extra == 'doc'
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- Requires-Dist: pyenchant; extra == 'doc'
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  Requires-Dist: pygments; extra == 'doc'
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+ Requires-Dist: scanpydoc; extra == 'doc'
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  Requires-Dist: sphinx-autodoc-typehints; extra == 'doc'
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  Requires-Dist: sphinx-automodapi; extra == 'doc'
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+ Requires-Dist: sphinx-book-theme; extra == 'doc'
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  Requires-Dist: sphinx-copybutton; extra == 'doc'
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  Requires-Dist: sphinx-design; extra == 'doc'
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  Requires-Dist: sphinx-gallery; extra == 'doc'
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+ Requires-Dist: sphinx-issues; extra == 'doc'
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  Requires-Dist: sphinx-last-updated-by-git; extra == 'doc'
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  Requires-Dist: sphinx-remove-toctrees; extra == 'doc'
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- Requires-Dist: sphinx>=4; extra == 'doc'
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+ Requires-Dist: sphinx>=6; extra == 'doc'
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  Requires-Dist: sphinxcontrib-bibtex>=1.0.0; extra == 'doc'
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  Requires-Dist: sphinxext-opengraph; extra == 'doc'
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+ Provides-Extra: tcoda
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+ Requires-Dist: ete4; extra == 'tcoda'
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+ Requires-Dist: pyqt6; extra == 'tcoda'
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+ Requires-Dist: toytree; extra == 'tcoda'
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  Provides-Extra: test
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  Requires-Dist: coverage; extra == 'test'
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+ Requires-Dist: leidenalg; extra == 'test'
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  Requires-Dist: pytest; extra == 'test'
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  Description-Content-Type: text/markdown
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@@ -127,10 +130,10 @@ You can install _pertpy_ in less than a minute via [pip] from [PyPI]:
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  pip install pertpy
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  ```
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- if you want to use scCODA or tascCODA, please install pertpy as follows:
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+ if you want to use tascCODA, please install pertpy as follows:
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  ```console
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- pip install 'pertpy[coda]'
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+ pip install 'pertpy[tcoda]'
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  ```
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  If you want to use the differential gene expression interface, please install pertpy by running:
@@ -146,4 +149,17 @@ bioRxiv 2024.08.04.606516; doi: https://doi.org/10.1101/2024.08.04.606516](https
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  [pip]: https://pip.pypa.io/
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  [pypi]: https://pypi.org/
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- [usage]: https://pertpy.readthedocs.io/en/latest/usage/usage.html
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+ [api]: https://pertpy.readthedocs.io/en/latest/api/api.html
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+ [//]: # "numfocus-fiscal-sponsor-attribution"
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+
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+ pertpy is part of the scverse® project ([website](https://scverse.org), [governance](https://scverse.org/about/roles)) and is fiscally sponsored by [NumFOCUS](https://numfocus.org/).
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+ If you like scverse® and want to support our mission, please consider making a tax-deductible [donation](https://numfocus.org/donate-to-scverse) to help the project pay for developer time, professional services, travel, workshops, and a variety of other needs.
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+
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+ <div align="center">
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+ <a href="https://numfocus.org/project/scverse">
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+ <img
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+ src="https://raw.githubusercontent.com/numfocus/templates/master/images/numfocus-logo.png"
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+ width="200"
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+ >
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+ </a>
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+ </div>
@@ -0,0 +1,58 @@
1
+ pertpy/__init__.py,sha256=2cNNXWvBztH3KQzxe5WEl_Krfh0tdax4pPg1iUYjhQE,716
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+ pertpy/_doc.py,sha256=j5TMNC-DA9yIMqIIUNpjpcVgWfRqyBBfvbRjnCM_OLs,427
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+ pertpy/_types.py,sha256=IcHCojCUqx8CapibNkcYf2TUqjBFP2ujeELvn_IBSBQ,154
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+ pertpy/py.typed,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
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+ pertpy/data/__init__.py,sha256=ah3yvoxkgbdMUNAWxS3SyqcUuVamBOSeuWkF2QRAEwM,2703
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+ pertpy/data/_dataloader.py,sha256=ZWDDvx8KmqkvMcjXEmGNeDyCceDur_osb-o2dDTHeQU,4397
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+ pertpy/data/_datasets.py,sha256=4IceyYURpstZSFRrD6gBjoYg8uRbEPo1QLXTt-SwB5k,65507
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+ pertpy/metadata/__init__.py,sha256=wROPCXmJX2v5schJaBTPQtGW-FGCNWPfO_6bpnXwk-c,276
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+ pertpy/metadata/_cell_line.py,sha256=xzlJV_loGS5yA3QaB2xnp0mlEgCWdoG1VPCrfbJKtMw,44494
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+ pertpy/metadata/_compound.py,sha256=ywNNqtib0exHv0z8ctmTRf1Hk64tSGWSiUEffycxf6A,4755
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+ pertpy/metadata/_drug.py,sha256=8QDSyxiFl25JdS80EQJC_krg6fEe5LIQEE6BsV1r8nY,9006
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+ pertpy/metadata/_look_up.py,sha256=4BuQlff_aAKFOKPojXDdxvH6uOkRlHzGeyxcjBc79OM,28682
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+ pertpy/metadata/_metadata.py,sha256=hV2LTFrExddLNU_RsDkZju6lQUSRoP4OIn_dumCyQao,3277
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+ pertpy/metadata/_moa.py,sha256=cSJimHZsPZ6tAXcl_aHOhyzUayf6fqtgAcJJ5KwRRsA,4698
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+ pertpy/plot/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
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+ pertpy/preprocessing/__init__.py,sha256=VAPFaeq2_qCvdFkQTCj_Hm460HC4Tersu8Rig_tnp_Y,71
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+ pertpy/preprocessing/_guide_rna.py,sha256=ijL-bjQ-9qn4r3DlhBxzsqk-bD4RqPsFlok-Otj4hg8,15872
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+ pertpy/preprocessing/_guide_rna_mixture.py,sha256=pT_YkjmN4iEJ-THBROu_dpbr8E6u8GJw36YoGseikD0,6422
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+ pertpy/tools/__init__.py,sha256=DhjK2mfjbtvg9vG1ox6dF7A7UgiPZ_qmVH5o0QaTQyk,2599
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+ pertpy/tools/_augur.py,sha256=7iB2_xq8knyxtmN0G_a0u37o8WPlMlJXZCwDqxGvoKQ,55296
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+ pertpy/tools/_cinemaot.py,sha256=54-rS0AEj31dMe7iU4kEmLoAunq3jNuhsBE3IEp9hrI,38071
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+ pertpy/tools/_dialogue.py,sha256=ngjDcJK0D6ukJwiyS9cLYjrDU82n1FJru8yx8TvKSt8,52384
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+ pertpy/tools/_enrichment.py,sha256=55mwotLH9DXQOhl85MCkxXu-MX0RysLyrPheJysAnF0,21369
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+ pertpy/tools/_milo.py,sha256=r-kZcpAcoQuhi41AnVuzh-cMIcV3HB3-RGzynHyDc1A,43712
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+ pertpy/tools/_mixscape.py,sha256=ob22FI1hqUtaEZzCqrocy0-k8iUOChItc2tdCDeNDGY,57173
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+ pertpy/tools/decoupler_LICENSE,sha256=OXLcl0T2SZ8Pmy2_dmlvKuetivmyPd5m1q-Gyd-zaYY,35149
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+ pertpy/tools/transferlearning_MMD_LICENSE,sha256=MUvDA-o_j9htRpI8fStVdCRuyLdPkQUuIH0a_EIc57w,1069
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+ pertpy/tools/_coda/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
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+ pertpy/tools/_coda/_base_coda.py,sha256=cITCEWyiPlxqS1Buhs8JzE3yHCdQksFitcXscEK7WX4,111504
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+ pertpy/tools/_coda/_sccoda.py,sha256=UjT9mha14YPk6jIqigAbyb1zqhrtBDV7b3NMWeoMFJ4,22575
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+ pertpy/tools/_coda/_tasccoda.py,sha256=hZBUhqpymFLu-l8CZ0FDLk04kUah9aSyHZwQhvHVm-U,30433
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+ pertpy/tools/_differential_gene_expression/__init__.py,sha256=SEydWg0iT3Y1pApjnCAOuHxFeI6xVUfgyBHv2s3LADU,487
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+ pertpy/tools/_differential_gene_expression/_base.py,sha256=PpfH_RZXsN79Bu0yBFPE9TXEqNsZ4bSzSbhM0wZou2I,38322
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+ pertpy/tools/_differential_gene_expression/_checks.py,sha256=hH_GP0lWGO-5zrCFX4YiIVCZBCuK0ZJ0jFmdlx2Qm4k,1639
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+ pertpy/tools/_differential_gene_expression/_dge_comparison.py,sha256=LXhp5djKKCAk9VI7OqxOuja849G5lnd8Ehcs9Epk8rg,4159
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+ pertpy/tools/_differential_gene_expression/_edger.py,sha256=nSHMDA4drGq_sJwUXs5I2EbMHwqjiS08GqOU_1_dXPc,4798
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+ pertpy/tools/_differential_gene_expression/_pydeseq2.py,sha256=OowFb67jHT-UwibvRolR6Vw_yHEAxQ_ybJ7a65HJg8M,2943
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+ pertpy/tools/_differential_gene_expression/_simple_tests.py,sha256=SfU8s_P2JzEA1RkmS0_xsARs4-BdnIYAwMmQv9-fxRg,6610
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+ pertpy/tools/_differential_gene_expression/_statsmodels.py,sha256=90h9EPuoCtNxAbJ1Xq4j_E4yYJJpk64zTP7GyTdmrxY,2220
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+ pertpy/tools/_distances/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
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+ pertpy/tools/_distances/_distance_tests.py,sha256=6_nqfHUfKxkI2Yhkzspq3ujMpq56zV_Ddn7bgPzgjyo,13513
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+ pertpy/tools/_distances/_distances.py,sha256=uzE8IcKPFYYXI0fKSgFHM_UIBZfA6uf9gBTSq8nZmZw,50496
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+ pertpy/tools/_perturbation_space/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
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+ pertpy/tools/_perturbation_space/_clustering.py,sha256=pNx_SpPkZfCbgF7vzHWqAaiiHdbxPaA-L-hTWTbzFhI,3528
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+ pertpy/tools/_perturbation_space/_comparison.py,sha256=-NzCPRT-IlhJ9hOz7NQLSk0riIzr2C0yZvX6zm3kon4,4291
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+ pertpy/tools/_perturbation_space/_discriminator_classifiers.py,sha256=gDid9Z1_AAPHPWuNgAkbP7yrgcC0qjjqTuWjTzTAAZo,23373
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+ pertpy/tools/_perturbation_space/_metrics.py,sha256=y8-baP8WRdB1iDgvP3uuQxSCDxA2lcxvEHHM2C_vWHY,3248
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+ pertpy/tools/_perturbation_space/_perturbation_space.py,sha256=8RxVUkVEPZj5YZ-C-NP5zO4aYYVD04PzlsYuaIG-wjY,19447
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+ pertpy/tools/_perturbation_space/_simple.py,sha256=nnagHJ_aPv4ZCqfnVLdVUT_JShtIXg7iEP_sCMD3JLY,14271
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+ pertpy/tools/_scgen/__init__.py,sha256=uERFlFyF88TH0uLiwmsUGEfHfLVCiZMFuk8gO5f7164,45
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+ pertpy/tools/_scgen/_base_components.py,sha256=Qq8myRUm43q9XBrZ9gBggfa2cSV2wbz_KYoLgH7iF1A,3009
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+ pertpy/tools/_scgen/_scgen.py,sha256=31T8ez0FxABIbunJHCk8xvGulHFb8RHXSsyM_z1WsPY,30850
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+ pertpy/tools/_scgen/_scgenvae.py,sha256=bPk4v7EdJc7ROdLuDitHiX_Pvwa7Flw2qHRUwBvjLJY,3889
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+ pertpy/tools/_scgen/_utils.py,sha256=qz5QUn_Bvk2NGyYVzp3jgjWTFOMt1YyHwUo6HWtoThY,2871
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+ pertpy-0.11.0.dist-info/METADATA,sha256=k17pDMEOKlDxSvRvG7D8iAA3jGidVvkOGrwuGef1uGc,7706
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+ pertpy-0.11.0.dist-info/WHEEL,sha256=qtCwoSJWgHk21S1Kb4ihdzI2rlJ1ZKaIurTj_ngOhyQ,87
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+ pertpy-0.11.0.dist-info/licenses/LICENSE,sha256=XuiT2hxeRInhquEIBKMZ5M21n5syhDQ4XbABoposIAg,1100
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+ pertpy-0.11.0.dist-info/RECORD,,
@@ -1,6 +1,7 @@
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  MIT License
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  Copyright (c) 2021, Lukas Heumos
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+ Copyright (c) 2025, scverse®
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  Permission is hereby granted, free of charge, to any person obtaining a copy
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  of this software and associated documentation files (the "Software"), to deal
@@ -1,50 +0,0 @@
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- from __future__ import annotations
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-
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- from typing import TYPE_CHECKING
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-
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- from sklearn.decomposition import KernelPCA
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-
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- if TYPE_CHECKING:
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- from anndata import AnnData
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-
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- def kernel_pca(
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- n_comps: int = 50,
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- kernel: str = "linear",
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- copy: bool = False,
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- return_transformer: bool = False,
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- **kwargs,
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- ):
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- """Compute kernel PCA on `adata.X`.
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-
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- Compute Kernel Principal component analysis (KPCA) using sklearn.
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- See also :class:`~sklearn.decomposition.KernelPCA`.
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-
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- Args:
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- adata: The annotated data object.
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- n_comps: Number of components. If None, all non-zero components are kept.
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- kernel: Kernel used for PCA.
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- copy: Determines whether a copy of the `adata` is returned.
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- return_transformer: Determines if the `KernelPCA` transformer is returned.
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- **kwargs: Additional arguments for the `KernelPCA` transformer.
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-
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- Returns:
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- If `copy=True`, returns the copy of `adata` with kernel pca in `.obsm["X_kpca"]`.
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- Otherwise, writes kernel pca directly to `.obsm["X_kpca"]` of the provided `adata`.
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- If `return_transformer=True`, returns also the fitted `KernelPCA` transformer.
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- """
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- if copy:
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- adata = adata.copy()
39
- transformer = KernelPCA(n_components=n_comps, kernel=kernel, **kwargs)
40
- X_kpca = transformer.fit_transform(adata.X)
41
- adata.obsm["X_kpca"] = X_kpca
42
-
43
- if copy:
44
- if return_transformer:
45
- return adata, transformer
46
- else:
47
- return adata
48
- else:
49
- if return_transformer:
50
- return transformer
@@ -1,57 +0,0 @@
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