gwaslab 3.4.41__py3-none-any.whl → 3.4.42__py3-none-any.whl
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- gwaslab/bd_common_data.py +14 -1
- gwaslab/bd_get_hapmap3.py +7 -3
- gwaslab/g_Sumstats.py +156 -138
- gwaslab/g_SumstatsPair.py +15 -15
- gwaslab/g_version.py +2 -2
- gwaslab/hm_harmonize_sumstats.py +365 -12
- gwaslab/io_read_tabular.py +7 -7
- gwaslab/io_to_formats.py +96 -21
- gwaslab/io_to_pickle.py +1 -1
- gwaslab/ldsc_ldscore.py +1 -1
- gwaslab/qc_fix_sumstats.py +2 -2
- gwaslab/util_ex_calculate_ldmatrix.py +2 -2
- gwaslab/util_ex_calculate_prs.py +2 -2
- gwaslab/util_ex_ldsc.py +163 -110
- gwaslab/util_ex_plink_filter.py +2 -2
- gwaslab/util_ex_run_clumping.py +2 -2
- gwaslab/util_in_filter_value.py +27 -9
- gwaslab/viz_plot_trumpetplot.py +115 -4
- {gwaslab-3.4.41.dist-info → gwaslab-3.4.42.dist-info}/METADATA +6 -3
- {gwaslab-3.4.41.dist-info → gwaslab-3.4.42.dist-info}/RECORD +24 -24
- {gwaslab-3.4.41.dist-info → gwaslab-3.4.42.dist-info}/WHEEL +1 -1
- {gwaslab-3.4.41.dist-info → gwaslab-3.4.42.dist-info}/LICENSE +0 -0
- {gwaslab-3.4.41.dist-info → gwaslab-3.4.42.dist-info}/LICENSE_before_v3.4.39 +0 -0
- {gwaslab-3.4.41.dist-info → gwaslab-3.4.42.dist-info}/top_level.txt +0 -0
gwaslab/viz_plot_trumpetplot.py
CHANGED
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@@ -13,6 +13,7 @@ from gwaslab.util_in_get_sig import annogene
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from gwaslab.viz_aux_annotate_plot import annotate_single
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from gwaslab.viz_aux_reposition_text import adjust_text_position
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from gwaslab.viz_aux_save_figure import save_figure
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from gwaslab.viz_plot_mqqplot import _process_highlight
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from gwaslab.g_Log import Log
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from gwaslab.util_in_calculate_power import get_beta
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from gwaslab.util_in_calculate_power import get_power
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@@ -49,6 +50,13 @@ def plottrumpet(mysumstats,
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xlim=None,
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markercolor="#597FBD",
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hue=None,
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highlight = None,
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highlight_chrpos = False,
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highlight_color="#CB132D",
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highlight_windowkb = 500,
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highlight_anno_args = None,
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pinpoint= None,
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pinpoint_color ="red",
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scatter_args=None,
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fontsize=15,
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font_family="Arial",
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@@ -106,7 +114,10 @@ def plottrumpet(mysumstats,
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scatter_args["hue"]=hue
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if markercolor is not None:
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scatter_args["color"]=markercolor
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-
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if highlight is None:
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highlight = list()
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if pinpoint is None:
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pinpoint = list()
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#Checking columns#################################################################################################################
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log.write("Start to create trumpet plot...", verbose=verbose)
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@@ -140,6 +151,10 @@ def plottrumpet(mysumstats,
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#loading columns #################################################################################################################
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cols_to_use = [snpid, beta, eaf, n, p]
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if len(highlight)>0:
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cols_to_use.append(pos)
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cols_to_use.append(chrom)
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if anno is not None:
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if anno != "GENENAME":
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if anno!=True:
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@@ -147,8 +162,8 @@ def plottrumpet(mysumstats,
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if anno not in cols_to_use:
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cols_to_use.append(anno)
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else:
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cols_to_use.append(pos)
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cols_to_use.append(chrom)
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cols_to_use.append(pos) if pos not in cols_to_use else cols_to_use
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cols_to_use.append(chrom) if chrom not in cols_to_use else cols_to_use
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if size != "ABS_BETA":
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if size not in cols_to_use:
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@@ -211,6 +226,16 @@ def plottrumpet(mysumstats,
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output_hex_colors.append(mc.to_hex(rgba[i]))
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output_hex_colors
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if len(highlight)>0:
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sumstats["HUE"] = pd.NA
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sumstats["HUE"] = sumstats["HUE"].astype("Int64")
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sumstats = _process_highlight(sumstats=sumstats,
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highlight=highlight,
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highlight_chrpos=highlight_chrpos,
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highlight_windowkb=highlight_windowkb,
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snpid=snpid,
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chrom=chrom,
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pos=pos)
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##################################################################################################
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fig, ax = plt.subplots(**figargs)
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@@ -256,18 +281,104 @@ def plottrumpet(mysumstats,
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sumstats["ABS_BETA"] = sumstats[beta].abs()
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##################################################################################################
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-
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size_norm = (sumstats["ABS_BETA"].min(), sumstats["ABS_BETA"].max())
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## if highlight ##################################################################################################
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dots = sns.scatterplot(data=sumstats,
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x=maf,
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y=beta,
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size=size,
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ax=ax,
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sizes=sizes,
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size_norm=size_norm,
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legend=True,
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edgecolor="black",
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alpha=0.8,
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zorder=2,
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**scatter_args)
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if len(highlight) >0:
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legend = None
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style=None
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linewidth=0
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edgecolor="black"
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if pd.api.types.is_list_like(highlight[0]) and highlight_chrpos==False:
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for i, highlight_set in enumerate(highlight):
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scatter_args["color"]=highlight_color[i%len(highlight_color)]
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log.write(" -Highlighting set {} target loci...".format(i+1),verbose=verbose)
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sns.scatterplot(data=sumstats.loc[sumstats["HUE"]==i], x=maf,
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y=beta,
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legend=legend,
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style=style,
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size=size,
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sizes=sizes,
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size_norm=size_norm,
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linewidth=linewidth,
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zorder=3+i,
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ax=ax,edgecolor=edgecolor,**scatter_args)
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else:
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log.write(" -Highlighting target loci...",verbose=verbose)
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scatter_args["color"]=highlight_color
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sns.scatterplot(data=sumstats.loc[sumstats["HUE"]==0], x=maf,
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y=beta,
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legend=legend,
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size=size,
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sizes=sizes,
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size_norm=size_norm,
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zorder=3,
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ax=ax,
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edgecolor="black",
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**scatter_args)
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####################################################################################################################
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if len(pinpoint)>0:
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legend = None
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style=None
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linewidth=0
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edgecolor="black"
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if pd.api.types.is_list_like(pinpoint[0]):
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for i, pinpoint_set in enumerate(pinpoint):
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scatter_args["color"]=pinpoint_color[i%len(pinpoint_color)]
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if sum(sumstats[snpid].isin(pinpoint_set))>0:
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to_pinpoint = sumstats.loc[sumstats[snpid].isin(pinpoint_set),:]
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log.write(" -Pinpointing set {} target vairants...".format(i+1),verbose=verbose)
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sns.scatterplot(data=to_pinpoint,
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x=maf,
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y=beta,
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legend=legend,
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size=size,
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sizes=sizes,
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size_norm=size_norm,
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zorder=3,
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ax=ax,
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edgecolor="black",
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**scatter_args)
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#ax.scatter(to_pinpoint[maf],to_pinpoint[beta],color=pinpoint_color[i%len(pinpoint_color)],zorder=100,s=to_pinpoint[size])
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else:
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log.write(" -Target vairants to pinpoint were not found. Skip pinpointing process...",verbose=verbose)
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else:
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scatter_args["color"]=pinpoint_color
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if sum(sumstats[snpid].isin(pinpoint))>0:
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to_pinpoint = sumstats.loc[sumstats[snpid].isin(pinpoint),:]
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log.write(" -Pinpointing target vairants...",verbose=verbose)
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sns.scatterplot(data=to_pinpoint, x=maf,
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y=beta,
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legend=legend,
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size=size,
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sizes=sizes,
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size_norm=size_norm,
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zorder=3,
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ax=ax,
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edgecolor="black",
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**scatter_args)
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#ax.scatter(to_pinpoint[maf],to_pinpoint[beta],color=pinpoint_color[i%len(pinpoint_color)],zorder=100,s=to_pinpoint[size])
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else:
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log.write(" -Target vairants to pinpoint were not found. Skip pinpointing process...",verbose=verbose)
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####################################################################################################################
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#second_legend = ax.legend(title="Power", loc="upper right",fontsize =fontsize,title_fontsize=fontsize)
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h,l = ax.get_legend_handles_labels()
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@@ -1,6 +1,6 @@
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Metadata-Version: 2.1
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Name: gwaslab
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Version: 3.4.
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Version: 3.4.42
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Summary: A collection of handy tools for GWAS SumStats
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Author-email: Yunye <yunye@gwaslab.com>
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Project-URL: Homepage, https://cloufield.github.io/gwaslab/
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### install via pip
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```
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pip install gwaslab==3.4.
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pip install gwaslab==3.4.41
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```
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```python
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```
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conda env create -n gwaslab_test -c conda-forge python=3.9
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conda activate gwaslab
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pip install gwaslab==3.4.
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pip install gwaslab==3.4.41
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```
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or create a new environment using yml file [environment_3.4.40.yml](https://github.com/Cloufield/gwaslab/blob/main/environment_3.4.40.yml)
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## Sample Data
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- Sample GWAS data used in GWASLab is obtained from: http://jenger.riken.jp/ (Suzuki, Ken, et al. "Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population." Nature genetics 51.3 (2019): 379-386.).
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## Acknowledgement
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Thanks to @sup3rgiu, @soumickmj and @gmauro for their contributions to the source codes.
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## Contacts
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* Github: [https://github.com/Cloufield/gwaslab](https://github.com/Cloufield/gwaslab)
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gwaslab/__init__.py,sha256=dFnrh4L620F5JirsSF98SmkuligA-fybIGdBF6r9Ims,2386
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gwaslab/bd_common_data.py,sha256=
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gwaslab/bd_common_data.py,sha256=v98X3tdRNOVE2gCiSHkfyBb0pSIjTk5IFG8A725Oj3o,12639
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gwaslab/bd_config.py,sha256=TP-r-DPhJD3XnRYZbw9bQHXaDIkiRgK8bG9HCt-UaLc,580
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gwaslab/bd_download.py,sha256=cDDk2C5IvjeAzvPvVYGTkI4Ss33DUtEDjGo8eAbQRvY,15663
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gwaslab/bd_get_hapmap3.py,sha256=
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gwaslab/bd_get_hapmap3.py,sha256=asNjQYeGfQi8u3jnfenRvDdKMs5ptql5wpcUzqMlwUI,3937
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gwaslab/g_Log.py,sha256=C3Zv-_6c3C9ms8bgQ-ytplz22sjk7euqXYkWr9zNeAs,1573
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gwaslab/g_Phenotypes.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
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gwaslab/g_Sumstats.py,sha256=
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gwaslab/g_SumstatsPair.py,sha256=
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gwaslab/g_Sumstats.py,sha256=GS0YUdvNYlwiR-mu6VJIv_JRqgBpHmTq9123XX5kiMI,35132
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gwaslab/g_SumstatsPair.py,sha256=tbgT-_1CqDEw22s4LbVJWF3ChELxz0gy1DEBzLc9ODU,8833
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gwaslab/g_SumstatsT.py,sha256=u_DighLMnMxwTLnqm-B58pA0G6WXRj6pudPyKMVKjSU,2133
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gwaslab/g_Sumstats_summary.py,sha256=FECvvFXJVKaCX5dggBvvk9YvJ6AbdbcLfjltysX7wEE,6380
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gwaslab/g_meta.py,sha256=htWlgURWclm9R6UqFcX1a93WN27xny7lGUeyJZOtszQ,2583
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gwaslab/g_vchange_status.py,sha256=eX0jdIb6Spa07ZdpWNqUWqdVBWS0fuH2yrt4PDi3Res,1746
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gwaslab/g_version.py,sha256=
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gwaslab/g_version.py,sha256=sYIrfQwAxGSUHOGcP64nhQ71-Cgzax3Xs18GM0Os_9k,1818
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gwaslab/hm_casting.py,sha256=FqP4EQl83Q2OKLw004OgLIvUH795TVCGwziLk5jsHqY,11368
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gwaslab/hm_harmonize_sumstats.py,sha256=
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gwaslab/hm_harmonize_sumstats.py,sha256=n6aygO8V7MJaDgkNHozNzIsm_G8KcR70ukS-IOygw0E,67684
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gwaslab/hm_rsid_to_chrpos.py,sha256=ODWREO0jPN0RAfNzL5fRzSRANfhiksOvUVPuEsFZQqA,6552
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gwaslab/io_preformat_input.py,sha256=w62JLAr16Ru0EgUtBCEV2eXRO89OqhidQxwf2IPAM38,20014
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gwaslab/io_read_ldsc.py,sha256=8S9n4imgl4d0WPms_GYld-6uUM5z7iWGiCA-M814kzY,12123
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gwaslab/io_read_tabular.py,sha256=
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gwaslab/io_to_formats.py,sha256=
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gwaslab/io_to_pickle.py,sha256=
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gwaslab/io_read_tabular.py,sha256=EG-C6KhCutt4J4LlOMgXnqzJvU-EZXzVhMvaDFnHrMM,2380
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gwaslab/io_to_formats.py,sha256=QuGWdvnAamaZAuhymj-0SuNBaKz1maTTyH396gvVaO8,29229
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gwaslab/io_to_pickle.py,sha256=HhePU0VcaGni0HTNU0BqoRaOnrr0NOxotgY6ISdx3Ck,1833
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gwaslab/ldsc_irwls.py,sha256=83JbAMAhD0KOfpv4IJa6LgUDfQjp4XSJveTjnhCBJYQ,6142
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gwaslab/ldsc_jackknife.py,sha256=XrWHoKS_Xn9StG1I83S2vUMTertsb-GH-_gOFYUhLeU,17715
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gwaslab/ldsc_ldscore.py,sha256=
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gwaslab/ldsc_ldscore.py,sha256=ZOxMvV3PhZzLsTmkKQqjabk_9PdrCTtPhbrdrpGmRAk,14580
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gwaslab/ldsc_parse.py,sha256=MBnfgcWlV4oHp9MoDRh1mpilaHhAR15Af77hMFn4-5k,10564
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gwaslab/ldsc_regressions.py,sha256=yzbGjgNV7u-SWXNPsh9S8y9mK97Bim_Nmad9G9V18ZU,30078
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gwaslab/ldsc_sumstats.py,sha256=O0olsDxKlh1MJ1gAuEN1t40rxhajOEwOQ20ak7xoDrI,26245
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gwaslab/qc_check_datatype.py,sha256=kW68uk4dTLOU2b1dHoVat6n0loundDysAjIqxsXW28Q,3379
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gwaslab/qc_fix_sumstats.py,sha256=
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gwaslab/run_script.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
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gwaslab/util_ex_calculate_ldmatrix.py,sha256=
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gwaslab/util_ex_calculate_prs.py,sha256=
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gwaslab/util_ex_calculate_ldmatrix.py,sha256=LpE__LoYRHLgVKlCHo6lYWlz9LEUVUDqYPEAP-Svbm0,14598
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gwaslab/util_ex_calculate_prs.py,sha256=5l1eiZs8YwIpEgp7i3IurP8n5KwQM5awbG9fWSm4iT4,9053
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gwaslab/util_ex_gwascatalog.py,sha256=--Gde9HrsikfYTeFqSaYz0gUODr9wmv_gV6GZGNlElg,7688
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gwaslab/util_ex_ldproxyfinder.py,sha256=wWNW9wITWozj23gT41LR00WxU-rrHpGKbxs2H_3jEyM,9431
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gwaslab/util_ex_ldsc.py,sha256=
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gwaslab/util_ex_plink_filter.py,sha256=
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gwaslab/util_ex_ldsc.py,sha256=a-OwyWmDcyinTPRfCNSeNYm6beVsydFeYmRAXAPcRnI,18350
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gwaslab/util_ex_plink_filter.py,sha256=pK1Yxtv9-J4rMOdVAG7VU9PktvI6-y4FxBiVEH0QuRs,1673
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gwaslab/util_ex_process_h5.py,sha256=ynFvo3zxgvOxWYL565v2IQf8P6iEuq7UlKQ_ULxrd6Y,2831
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gwaslab/util_ex_process_ref.py,sha256=BwS4hmzIWdgmRY_yiG6RJQJHjYcOR-2yZX7kU3s8lPw,16552
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gwaslab/util_ex_run_2samplemr.py,sha256=5c0DGF694T9j0Y58L2I7pr1_Z1hfpaatIgix7P5oPA8,9127
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gwaslab/util_ex_run_clumping.py,sha256=
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gwaslab/util_ex_run_clumping.py,sha256=Y8KeUKuSpGc1a8iI_VKUgVQpAVBd7O9F11p85jY4oW4,7868
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gwaslab/util_ex_run_coloc.py,sha256=u57h8wPbTCOf6aY5u5DpzK1gv7inuDT8a15UGo-1ras,6288
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gwaslab/util_ex_run_susie.py,sha256=TXqiwBVq1io7XSlLF2_gNsYgxDLiKNnYE9pIjRWJ1Hc,5315
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gwaslab/util_in_calculate_gc.py,sha256=MWOXVzJv7SZx4i2_ncRiqsiEOADc7EfghaUzgGy4jaE,2219
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@@ -46,7 +46,7 @@ gwaslab/util_in_calculate_power.py,sha256=JfHJFg3tNF0f4NHgWlzVW2mSxCiP07mAHIyEfV
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gwaslab/util_in_convert_h2.py,sha256=a8Cbudt3xn9WP2bPc-7ysuowB-LYub8j8GeDXl7Lk7Q,6483
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gwaslab/util_in_correct_winnerscurse.py,sha256=Gp--yAQ8MMzdkWIvXP9C1BHVjZc-YzqHfYWhAj19w9w,2110
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gwaslab/util_in_fill_data.py,sha256=gdTwYA6FvBMnrtxAeL0lEj_Z0aGIoRNPScWDlJvZWeQ,14021
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gwaslab/util_in_filter_value.py,sha256=
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gwaslab/util_in_filter_value.py,sha256=6yz3omukfqhmkfGZwGtr2BPQ6FcSTj4l6o7EhPMXRz0,22100
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gwaslab/util_in_get_density.py,sha256=kpKXH69acMkeYVG5vs-VbJC3COhmuLBfYco-wuOxgjc,3934
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gwaslab/util_in_get_sig.py,sha256=atyBJZCWGUSgy-nvIR8_a_isseq1nKhzTaRVG2LbKQk,37762
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gwaslab/viz_aux_annotate_plot.py,sha256=R-1GT89E4NEBAMNTYzNawdi9rjQV5LCnODgnYOOKsys,32184
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@@ -63,7 +63,7 @@ gwaslab/viz_plot_qqplot.py,sha256=psQgVpP29686CEZkzQz0iRbApzqy7aE3GGiBcazVvNw,72
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gwaslab/viz_plot_regionalplot.py,sha256=PBIWkNj2fj-dRLKQJNpM8wor5jya2anqix0-UYLE0Is,37901
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gwaslab/viz_plot_rg_heatmap.py,sha256=PidUsgOiEVt6MfBPCF3_yDhOEytZ-I1q-ZD6_0pFrV4,13713
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gwaslab/viz_plot_stackedregional.py,sha256=EAHz5SZGengZ_pxcOg62ZRimGRz6_goQlp9MLCwmeZc,11890
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gwaslab/viz_plot_trumpetplot.py,sha256=
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gwaslab/viz_plot_trumpetplot.py,sha256=ZHdc6WcVx0-oKoj88yglRkmB4bS9pOiEMcuwKW35Yvo,42672
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gwaslab/data/formatbook.json,sha256=N2nJs80HH98Rsu9FxaSvIQO9J5yIV97WEtAKjRqYwiY,38207
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gwaslab/data/reference.json,sha256=k8AvvgDsuLxzv-NCJHWvTUZ5q_DLAFxs1Th3jtL313k,11441
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gwaslab/data/chrx_par/chrx_par_hg19.bed.gz,sha256=LocZg_ozhZjQiIpgWCO4EYCW9xgkEKpRy1m-YdIpzQs,83
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gwaslab/data/hapmap3_SNPs/hapmap3_db151_hg38.snplist.gz,sha256=Y8ZT2FIAhbhlgCJdE9qQVAiwnV_fcsPt72usBa7RSBM,10225828
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gwaslab/data/high_ld/high_ld_hla_hg19.bed.gz,sha256=R7IkssKu0L4WwkU9SrS84xCMdrkkKL0gnTNO_OKbG0Y,219
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gwaslab/data/high_ld/high_ld_hla_hg38.bed.gz,sha256=76CIU0pibDJ72Y6UY-TbIKE9gEPwTELAaIbCXyjm80Q,470
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gwaslab-3.4.
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gwaslab-3.4.42.dist-info/LICENSE,sha256=OXLcl0T2SZ8Pmy2_dmlvKuetivmyPd5m1q-Gyd-zaYY,35149
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gwaslab-3.4.42.dist-info/LICENSE_before_v3.4.39,sha256=GhLOU_1UDEKeOacYhsRN_m9u-eIuVTazSndZPeNcTZA,1066
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gwaslab-3.4.42.dist-info/METADATA,sha256=iqArSw_x7yXovyF9D-z3gt5fzskQSOVObXPWCrYIcsg,7714
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gwaslab-3.4.42.dist-info/WHEEL,sha256=GJ7t_kWBFywbagK5eo9IoUwLW6oyOeTKmQ-9iHFVNxQ,92
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gwaslab-3.4.42.dist-info/top_level.txt,sha256=PyY6hWtrALpv2MAN3kjkIAzJNmmBTH5a2risz9KwH08,8
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gwaslab-3.4.42.dist-info/RECORD,,
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