biotite 1.1.0__cp313-cp313-macosx_11_0_arm64.whl

biotite/database/pubchem/query.py

@@ -0,0 +1,830 @@
+# This source code is part of the Biotite package and is distributed
+# under the 3-Clause BSD License. Please see 'LICENSE.rst' for further
+# information.
+
+__name__ = "biotite.database.pubchem"
+__author__ = "Patrick Kunzmann"
+__all__ = [
+    "Query",
+    "NameQuery",
+    "SmilesQuery",
+    "InchiQuery",
+    "InchiKeyQuery",
+    "FormulaQuery",
+    "SuperstructureQuery",
+    "SubstructureQuery",
+    "SimilarityQuery",
+    "IdentityQuery",
+    "search",
+]
+
+import abc
+import collections
+import copy
+import requests
+from biotite.database.error import RequestError
+from biotite.database.pubchem.error import parse_error_details
+from biotite.database.pubchem.throttle import ThrottleStatus
+from biotite.structure.io.mol.mol import MOLFile
+
+_base_url = "https://pubchem.ncbi.nlm.nih.gov/rest/pug/"
+
+
+class Query(metaclass=abc.ABCMeta):
+    """
+    A search query for the *PubChem* REST API.
+    Unlike most other database interfaces in *Biotite*, multiple queries
+    cannot be combined using logical operators.
+
+    This is the abstract base class for all queries.
+    """
+
+    @abc.abstractmethod
+    def get_input_url_path(self):
+        """
+        Get the *input* part of the request URL.
+
+        Returns
+        -------
+        get_input_url_path : str
+            The *input* part of the request URL.
+            Must not contain slash characters at the beginning and end
+            of the string.
+        """
+        pass
+
+    def get_params(self):
+        """
+        Get the POST payload for this query.
+
+        Returns
+        -------
+        params : dict (str -> object)
+            The payload.
+        """
+        return {}
+
+    def get_files(self):
+        """
+        Get the POST file payload for this query.
+
+        Returns
+        -------
+        params : dict (str -> object)
+            The file payload.
+        """
+        return {}
+
+
+class NameQuery(Query):
+    """
+    A query that searches for compounds with the given name.
+
+    The name of the compound must match the given name completely,
+    but synonyms of the compound name are also considered.
+
+    Parameters
+    ----------
+    name : str
+        The compound name to be searched.
+
+    Examples
+    --------
+
+    >>> print(search(NameQuery("Alanine")))
+    [5950, ..., ...]
+    """
+
+    def __init__(self, name):
+        self._name = name
+
+    def get_input_url_path(self):
+        return "compound/name"
+
+    def get_params(self):
+        return {"name": self._name}
+
+
+class SmilesQuery(Query):
+    """
+    A query that searches for compounds with a given
+    *Simplified Molecular Input Line Entry Specification* (*SMILES*)
+    string.
+
+    Parameters
+    ----------
+    smiles : str
+        The *SMILES* string.
+
+    Examples
+    --------
+
+    >>> print(search(SmilesQuery("CCCC")))
+    [7843]
+    """
+
+    def __init__(self, smiles):
+        self._smiles = smiles
+
+    def get_input_url_path(self):
+        return "compound/smiles"
+
+    def get_params(self):
+        return {"smiles": self._smiles}
+
+
+class InchiQuery(Query):
+    """
+    A query that searches for compounds with a given
+    *International Chemical Identifier* (*InChI*) string.
+
+    Parameters
+    ----------
+    inchi : str
+        The *InChI* string.
+
+    Examples
+    --------
+
+    >>> print(search(InchiQuery("InChI=1S/C4H10/c1-3-4-2/h3-4H2,1-2H3")))
+    [7843]
+    """
+
+    def __init__(self, inchi):
+        self._inchi = inchi
+
+    def get_input_url_path(self):
+        return "compound/inchi"
+
+    def get_params(self):
+        return {"inchi": self._inchi}
+
+
+class InchiKeyQuery(Query):
+    """
+    A query that searches for compounds with a given
+    *International Chemical Identifier* (*InChI*) key.
+
+    Parameters
+    ----------
+    inchi_key : str
+        The *InChI* key.
+
+    Examples
+    --------
+
+    >>> print(search(InchiKeyQuery("IJDNQMDRQITEOD-UHFFFAOYSA-N")))
+    [7843]
+    """
+
+    def __init__(self, inchi_key):
+        self._inchi_key = inchi_key
+
+    def get_input_url_path(self):
+        return "compound/inchikey"
+
+    def get_params(self):
+        return {"inchikey": self._inchi_key}
+
+
+class FormulaQuery(Query):
+    """
+    A query that searches for compounds with the given molecular
+    formula.
+
+    The formula can also be created from an :class:`AtomArray` using
+    the :meth:`from_atoms()` method.
+
+    Parameters
+    ----------
+    formula : str
+        The molecular formula, i.e. each capitalized element with its
+        count in the compound concatenated into a single string.
+    allow_other_elements : bool, optional
+        If set to true, compounds with additional elements, not present
+        in the molecular formula, will also match.
+    number : int, optional
+        The maximum number of matches that this query may return.
+        By default, the *PubChem* default value is used, which can be
+        considered unlimited.
+
+    Examples
+    --------
+
+    >>> print(search(FormulaQuery("C4H10", number=5)))
+    [..., ..., ..., ..., ...]
+    >>> atom_array = residue("ALA")
+    >>> print(search(FormulaQuery.from_atoms(atom_array, number=5)))
+    [..., ..., ..., ..., ...]
+    """
+
+    def __init__(self, formula, allow_other_elements=False, number=None):
+        self._formula = formula
+        self._allow_other_elements = allow_other_elements
+        self._number = number
+
+    @staticmethod
+    def from_atoms(atoms, allow_other_elements=False, number=None):
+        """
+        Create the query from an the given structure by using its
+        molecular formula.
+
+        Parameters
+        ----------
+        atoms : AtomArray or AtomArrayStack
+            The structure to take the molecular formula from.
+        allow_other_elements : bool, optional
+            If set to true, compounds with additional elements, not
+            present in the molecular formula, will also match.
+        number : int, optional
+            The maximum number of matches that this query may return.
+            By default, the *PubChem* default value is used, which can
+            be considered unlimited.
+        """
+        element_counter = collections.Counter(atoms.element)
+        formula = ""
+        # C and H come first in molecular formula
+        if "C" in element_counter:
+            formula += _format_element("C", element_counter["C"])
+            del element_counter["C"]
+        if "H" in element_counter:
+            formula += _format_element("H", element_counter["H"])
+            del element_counter["H"]
+        # All other elements follow in alphabetical order
+        sorted_elements = sorted(element_counter.keys())
+        for element in sorted_elements:
+            formula += _format_element(element, element_counter[element])
+        return FormulaQuery(formula, allow_other_elements, number)
+
+    def get_input_url_path(self):
+        # The 'fastformula' service seems not to accept the formula
+        # in the parameter section of the request
+        return f"compound/fastformula/{self._formula}"
+
+    def get_params(self):
+        params = {"AllowOtherElements": self._allow_other_elements}
+        # Only set maximum number, if provided by the user
+        # The PubChem default value for this might change over time
+        if self._number is not None:
+            params["MaxRecords"] = self._number
+        return params
+
+
+def _format_element(element, count):
+    if count == 1:
+        return element.capitalize()
+    else:
+        return element.capitalize() + str(count)
+
+
+class StructureQuery(Query, metaclass=abc.ABCMeta):
+    """
+    Abstract superclass for all structure based searches.
+    This class handles structure inputs and option formatting.
+
+    Exactly one of the input structure parameters `smiles`, `smarts`,
+    `inchi`, `sdf` or `cid` must be given.
+
+    Parameters
+    ----------
+    smiles : str, optional
+        The query *SMILES* string.
+    smarts : str, optional
+        The query *SMARTS* pattern.
+    inchi : str, optional
+        The query *InChI* string.
+    sdf : str, optional
+        A query structure as SDF formatted string.
+        Usually :meth:`from_atoms()` is used to create the SDF from an
+        :class:`AtomArray`.
+    cid : int, optional
+        The query structure given as CID.
+    number : int, optional
+        The maximum number of matches that this query may return.
+        By default, the *PubChem* default value is used, which can
+        be considered unlimited.
+    """
+
+    _query_keys = ("smiles", "smarts", "inchi", "sdf", "cid")
+
+    def __init__(self, **kwargs):
+        query_key_found = False
+        for query_key in StructureQuery._query_keys:
+            if query_key in kwargs:
+                if not query_key_found:
+                    self._query_key = query_key
+                    self._query_val = kwargs[query_key]
+                    # Delete parameter from kwargs for later check for
+                    # unused (invalid) parameters
+                    del kwargs[query_key]
+                    query_key_found = True
+                else:
+                    # A query key was already found,
+                    # duplicates are not allowed
+                    raise TypeError(
+                        "Only one of 'smiles', 'smarts', 'inchi', 'sdf' or "
+                        "'cid' may be given"
+                    )
+        if not query_key_found:
+            raise TypeError(
+                "Expected exactly one of 'smiles', 'smarts', 'inchi', 'sdf' " "or 'cid'"
+            )
+        if "number" in kwargs:
+            self._number = kwargs["number"]
+            del kwargs["number"]
+        else:
+            self._number = None
+        # If there are still remaining parameters that were not handled
+        # by this superclass or the inheriting class, they are invalid
+        for key in kwargs:
+            raise TypeError(f"'{key}' is an invalid keyword argument")
+
+    @classmethod
+    def from_atoms(cls, atoms, *args, **kwargs):
+        """
+        Create a query using the given query structure.
+
+        Parameters
+        ----------
+        atoms : AtomArray or AtomArrayStack
+            The query structure.
+        **kwargs : dict, optional
+            See the constructor for additional options.
+        """
+        mol_file = MOLFile()
+        mol_file.set_structure(atoms)
+        # Every MOL string with "$$$$" is a valid SDF string
+        # Important: USE MS-style new lines
+        return cls(*args, sdf="\r\n".join(mol_file.lines) + "\r\n$$$$\r\n", **kwargs)
+
+    def get_input_url_path(self):
+        input_string = f"compound/{self.search_type()}/{self._query_key}"
+        if self._query_key == "cid":
+            # Put CID in URL and not in POST payload,
+            # as PubChem is confused otherwise
+            input_string += "/" + str(self._query_val)
+        return input_string
+
+    def get_params(self):
+        if self._query_key not in ("cid", "sdf"):
+            # CID is in URL
+            # SDF is given as file
+            params = {self._query_key: self._query_val}
+        else:
+            params = {}
+        # Only set maximum number, if provided by the user
+        # The PubChem default value for this might change over time
+        if self._number is not None:
+            params["MaxRecords"] = self._number
+        for key, val in self.search_options().items():
+            # Convert 'snake case' Python parameters
+            # to 'camel case' request parameters
+            key = "".join([word.capitalize() for word in key.split("_")])
+            params[key] = val
+        return params
+
+    def get_files(self):
+        # Multi-line SDF string requires payload as file
+        if self._query_key == "sdf":
+            return {"sdf": self._query_val}
+        else:
+            return {}
+
+    @abc.abstractmethod
+    def search_type(self):
+        """
+        Get the type of performed search for the request input part.
+
+        PROTECTED: Override when inheriting.
+
+        Returns
+        -------
+        search_type : str
+            The search type for the input part, i.e. the part directly
+            after ``compound/``.
+        """
+        pass
+
+    def search_options(self):
+        """
+        Get additional options for the POST options.
+
+        PROTECTED: Override when inheriting.
+
+        Returns
+        -------
+        options : dict (str -> object)
+            They keys are automatically converted from *snake case* to
+            *camel case* required by the request parameters.
+        """
+        return {}
+
+
+class SuperOrSubstructureQuery(StructureQuery, metaclass=abc.ABCMeta):
+    """
+    Abstract superclass for super- and substructure searches.
+    This class handles specific options for these searches.
+
+    Exactly one of the input structure parameters `smiles`, `smarts`,
+    `inchi`, `sdf` or `cid` must be given.
+
+    Parameters
+    ----------
+    smiles : str, optional
+        The query *SMILES* string.
+    smarts : str, optional
+        The query *SMARTS* pattern.
+    inchi : str, optional
+        The query *InChI* string.
+    sdf : str, optional
+        A query structure as SDF formatted string.
+        Usually :meth:`from_atoms()` is used to create the SDF from an
+        :class:`AtomArray`.
+    cid : int, optional
+        The query structure given as CID.
+    number : int, optional
+        The maximum number of matches that this query may return.
+        By default, the *PubChem* default value is used, which can
+        be considered unlimited.
+    match_charges : bool, optional
+        If set to true, atoms must match the specified charge.
+        (Default: False)
+    match_tautomers : bool, optional
+        If set to true, allow match to tautomers of the given structure.
+        (Default: False)
+    rings_not_embedded : bool, optional
+        If set to true, rings may not be embedded in a larger system.
+        (Default: False)
+    single_double_bonds_match : bool, optional
+        If set to true, single or double bonds match aromatic bonds.
+        (Default: True)
+    chains_match_rings : bool, optional
+        If set to true, chain bonds in the query may match rings in
+        hits.
+        (Default: True)
+    strip_hydrogen : bool, optional
+        If set to true, remove any explicit hydrogens before searching.
+        (Default: False)
+    stereo : {'ignore', 'exact', 'relative', 'nonconflicting'}, optional
+        How to handle stereo.
+        (Default: 'ignore')
+
+    Notes
+    -----
+    Optional parameter descriptions are taken from the *PubChem* REST
+    API
+    `documentation <https://pubchem.ncbi.nlm.nih.gov/docs/pug-rest#section=Substructure-Superstructure>`_.
+    """
+
+    _option_defaults = {
+        "match_charges": False,
+        "match_tautomers": False,
+        "rings_not_embedded": False,
+        "single_double_bonds_match": True,
+        "chains_match_rings": True,
+        "strip_hydrogen": False,
+        "stereo": "ignore",
+    }
+
+    def __init__(self, **kwargs):
+        self._options = copy.copy(SuperOrSubstructureQuery._option_defaults)
+        for option, value in kwargs.items():
+            if option in SuperOrSubstructureQuery._option_defaults.keys():
+                self._options[option] = value
+                del kwargs[option]
+        super().__init__(**kwargs)
+
+    def search_options(self):
+        return self._options
+
+
+class SuperstructureQuery(SuperOrSubstructureQuery):
+    """
+    A query that searches for all structures, where the given
+    input structure is a superstructure.
+    In other words, this query matches substructures of the input
+    structure.
+
+    Exactly one of the input structure parameters `smiles`, `smarts`,
+    `inchi`, `sdf` or `cid` must be given.
+
+    Parameters
+    ----------
+    smiles : str, optional
+        The query *SMILES* string.
+    smarts : str, optional
+        The query *SMARTS* pattern.
+    inchi : str, optional
+        The query *InChI* string.
+    sdf : str, optional
+        A query structure as SDF formatted string.
+        Usually :meth:`from_atoms()` is used to create the SDF from an
+        :class:`AtomArray`.
+    cid : int, optional
+        The query structure given as CID.
+    number : int, optional
+        The maximum number of matches that this query may return.
+        By default, the *PubChem* default value is used, which can
+        be considered unlimited.
+    match_charges : bool, optional
+        If set to true, atoms must match the specified charge.
+        (Default: False)
+    match_tautomers : bool, optional
+        If set to true, allow match to tautomers of the given structure.
+        (Default: False)
+    rings_not_embedded : bool, optional
+        If set to true, rings may not be embedded in a larger system.
+        (Default: False)
+    single_double_bonds_match : bool, optional
+        If set to true, single or double bonds match aromatic bonds.
+        (Default: True)
+    chains_match_rings : bool, optional
+        If set to true, chain bonds in the query may match rings in
+        hits.
+        (Default: True)
+    strip_hydrogen : bool, optional
+        If set to true, remove any explicit hydrogens before searching.
+        (Default: False)
+    stereo : {'ignore', 'exact', 'relative', 'nonconflicting'}, optional
+        How to handle stereo.
+        (Default: 'ignore')
+
+    Notes
+    -----
+    Optional parameter descriptions are taken from the *PubChem* REST
+    API
+    `documentation <https://pubchem.ncbi.nlm.nih.gov/docs/pug-rest#section=Substructure-Superstructure>`_.
+
+    Examples
+    --------
+
+    >>> # CID of alanine
+    >>> print(search(SuperstructureQuery(cid=5950, number=5)))
+    [..., ..., ..., ..., ...]
+    >>> # AtomArray of alanine
+    >>> atom_array = residue("ALA")
+    >>> print(search(SuperstructureQuery.from_atoms(atom_array, number=5)))
+    [..., ..., ..., ..., ...]
+    """
+
+    def search_type(self):
+        return "fastsuperstructure"
+
+
+class SubstructureQuery(SuperOrSubstructureQuery):
+    """
+    A query that searches for all structures, where the given
+    input structure is a substructure.
+    In other words, this query matches superstructures of the input
+    structure.
+
+    Exactly one of the input structure parameters `smiles`, `smarts`,
+    `inchi`, `sdf` or `cid` must be given.
+
+    Parameters
+    ----------
+    smiles : str, optional
+        The query *SMILES* string.
+    smarts : str, optional
+        The query *SMARTS* pattern.
+    inchi : str, optional
+        The query *InChI* string.
+    sdf : str, optional
+        A query structure as SDF formatted string.
+        Usually :meth:`from_atoms()` is used to create the SDF from an
+        :class:`AtomArray`.
+    cid : int, optional
+        The query structure given as CID.
+    number : int, optional
+        The maximum number of matches that this query may return.
+        By default, the *PubChem* default value is used, which can
+        be considered unlimited.
+    match_charges : bool, optional
+        If set to true, atoms must match the specified charge.
+        (Default: False)
+    match_tautomers : bool, optional
+        If set to true, allow match to tautomers of the given structure.
+        (Default: False)
+    rings_not_embedded : bool, optional
+        If set to true, rings may not be embedded in a larger system.
+        (Default: False)
+    single_double_bonds_match : bool, optional
+        If set to true, single or double bonds match aromatic bonds.
+        (Default: True)
+    chains_match_rings : bool, optional
+        If set to true, chain bonds in the query may match rings in
+        hits.
+        (Default: True)
+    strip_hydrogen : bool, optional
+        If set to true, remove any explicit hydrogens before searching.
+        (Default: False)
+    stereo : {'ignore', 'exact', 'relative', 'nonconflicting'}, optional
+        How to handle stereo.
+        (Default: 'ignore')
+
+    Notes
+    -----
+    Optional parameter descriptions are taken from the *PubChem* REST
+    API
+    `documentation <https://pubchem.ncbi.nlm.nih.gov/docs/pug-rest#section=Substructure-Superstructure>`_.
+
+    Examples
+    --------
+
+    >>> # CID of alanine
+    >>> print(search(SubstructureQuery(cid=5950, number=5)))
+    [5950, ..., ..., ..., ...]
+    >>> # AtomArray of alanine
+    >>> atom_array = residue("ALA")
+    >>> print(search(SubstructureQuery.from_atoms(atom_array, number=5)))
+    [5950, ..., ..., ..., ...]
+    """
+
+    def search_type(self):
+        return "fastsubstructure"
+
+
+class SimilarityQuery(StructureQuery):
+    """
+    A query that searches for all structures similar to the given
+    input structure.
+
+    Exactly one of the input structure parameters `smiles`, `smarts`,
+    `inchi`, `sdf` or `cid` must be given.
+
+    Parameters
+    ----------
+    threshold : float, optional
+        The minimum required *Tanimoto* similarity for a match.
+        Must be between 0 (no similarity) and 1 (complete match).
+    conformation_based : bool, optional
+        If set to true, the similarity is computed based on the
+        3D conformation.
+        By default, only the elements and bonds between the atoms are
+        considered for similarity computation.
+    smiles : str, optional
+        The query *SMILES* string.
+    smarts : str, optional
+        The query *SMARTS* pattern.
+    inchi : str, optional
+        The query *InChI* string.
+    sdf : str, optional
+        A query structure as SDF formatted string.
+        Usually :meth:`from_atoms()` is used to create the SDF from an
+        :class:`AtomArray`.
+    cid : int, optional
+        The query structure given as CID.
+    number : int, optional
+        The maximum number of matches that this query may return.
+        By default, the *PubChem* default value is used, which can
+        be considered unlimited.
+
+    Notes
+    -----
+    The conformation based similarity measure uses *shape-Tanimoto* and
+    *color-Tanimoto* scores :footcite:`Kim2018`.
+
+    References
+    ----------
+
+    .. footbibliography::
+
+    Examples
+    --------
+
+    >>> # CID of alanine
+    >>> print(search(SimilarityQuery(cid=5950, threshold=1.0, number=5)))
+    [5950, ..., ..., ..., ...]
+    >>> # AtomArray of alanine
+    >>> atom_array = residue("ALA")
+    >>> print(search(SimilarityQuery.from_atoms(atom_array, threshold=1.0, number=5)))
+    [5950, ..., ..., ..., ...]
+    """
+
+    def __init__(self, threshold=0.9, conformation_based=False, **kwargs):
+        self._threshold = threshold
+        self._conformation_based = conformation_based
+        super().__init__(**kwargs)
+
+    def search_type(self):
+        dim = "3d" if self._conformation_based else "2d"
+        return f"fastsimilarity_{dim}"
+
+    def search_options(self):
+        return {"threshold": int(round(self._threshold * 100))}
+
+
+class IdentityQuery(StructureQuery):
+    """
+    A query that searches for all structures that are identical to the
+    given input structure.
+
+    Exactly one of the input structure parameters `smiles`, `smarts`, `inchi`,
+    `sdf` or `cid` must be given.
+
+    Parameters
+    ----------
+    identity_type : {'same_connectivity', 'same_tautomer', 'same_stereo', 'same_isotope', 'same_stereo_isotope', 'nonconflicting_stereo', 'same_isotope_nonconflicting_stereo'}, optional
+        The type of identity search.
+    smiles : str, optional
+        The query *SMILES* string.
+    smarts : str, optional
+        The query *SMARTS* pattern.
+    inchi : str, optional
+        The query *InChI* string.
+    sdf : str, optional
+        A query structure as SDF formatted string.
+        Usually :meth:`from_atoms()` is used to create the SDF from an
+        :class:`AtomArray`.
+    cid : int, optional
+        The query structure given as CID.
+    number : int, optional
+        The maximum number of matches that this query may return.
+        By default, the *PubChem* default value is used, which can
+        be considered unlimited.
+
+    Examples
+    --------
+
+    >>> # CID of alanine
+    >>> print(search(IdentityQuery(cid=5950)))
+    [5950]
+    >>> # AtomArray of alanine
+    >>> atom_array = residue("ALA")
+    >>> print(search(IdentityQuery.from_atoms(atom_array)))
+    [5950]
+    """
+
+    def __init__(self, identity_type="same_stereo_isotope", **kwargs):
+        self._identity_type = identity_type
+        super().__init__(**kwargs)
+
+    def search_type(self):
+        return "fastidentity"
+
+    def get_params(self):
+        # Use 'get_params()' instead of 'search_options()', since the
+        # parameter 'identity_type' in the REST API is *snake case*
+        # -> Conversion to *camel case* is undesirable
+        params = super().get_params()
+        params["identity_type"] = self._identity_type
+        return params
+
+
+def search(query, throttle_threshold=0.5, return_throttle_status=False):
+    """
+    Get all CIDs that meet the given query requirements,
+    via the PubChem REST API.
+
+    This function requires an internet connection.
+
+    Parameters
+    ----------
+    query : Query
+        The search query.
+    throttle_threshold : float or None, optional
+        A value between 0 and 1.
+        If the load of either the request time or count exceeds this
+        value the execution is halted.
+        See :class:`ThrottleStatus` for more information.
+        If ``None`` is given, the execution is never halted.
+    return_throttle_status : float, optional
+        If set to true, the :class:`ThrottleStatus` is also returned.
+
+    Returns
+    -------
+    ids : list of int
+        List of all compound IDs (CIDs) that meet the query requirement.
+    throttle_status : ThrottleStatus
+        The :class:`ThrottleStatus` obtained from the server response.
+        This can be used for custom request throttling, for example.
+        Only returned, if `return_throttle_status` is set to true.
+
+    Examples
+    --------
+
+    >>> print(search(NameQuery("Alanine")))
+    [5950, ..., ...]
+    """
+    # Use POST to be compatible with the larger payloads
+    # of structure searches
+    if query.get_files():
+        files = {key: file for key, file in query.get_files().items()}
+    else:
+        files = None
+    r = requests.post(
+        _base_url + query.get_input_url_path() + "/cids/TXT",
+        data=query.get_params(),
+        files=files,
+    )
+    if not r.ok:
+        raise RequestError(parse_error_details(r.text))
+    throttle_status = ThrottleStatus.from_response(r)
+    if throttle_threshold is not None:
+        throttle_status.wait_if_busy(throttle_threshold)
+
+    cids = [int(cid) for cid in r.text.splitlines()]
+    if return_throttle_status:
+        return cids, throttle_status
+    else:
+        return cids