bioai-evidence-validator 0.4.1__py3-none-any.whl

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+ Metadata-Version: 2.5
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+ Name: bioai-evidence-validator
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+ Version: 0.4.1
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+ Summary: Standards-aligned evidence policy validation for AI-assisted biological curation
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+ Project-URL: Homepage, https://github.com/NingyuSUN/bioai-evidence-validator
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+ Project-URL: Documentation, https://github.com/NingyuSUN/bioai-evidence-validator/tree/main/docs
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+ Project-URL: Changelog, https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/CHANGELOG.md
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+ Project-URL: Issues, https://github.com/NingyuSUN/bioai-evidence-validator/issues
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+ Author: Ningyu Sun
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+ License: Apache-2.0
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+ License-File: LICENSE
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+ Keywords: ai-safety,biocuration,bioinformatics,evidence,knowledge-graph,linkml,llm,ontology,provenance,validation
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+ Classifier: Development Status :: 4 - Beta
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+ Classifier: Intended Audience :: Science/Research
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+ Classifier: Operating System :: OS Independent
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+ Classifier: Programming Language :: Python :: 3
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+ Classifier: Programming Language :: Python :: 3 :: Only
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+ Classifier: Programming Language :: Python :: 3.11
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+ Classifier: Programming Language :: Python :: 3.12
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+ Classifier: Programming Language :: Python :: 3.13
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+ Classifier: Topic :: Scientific/Engineering :: Artificial Intelligence
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+ Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
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+ Requires-Python: >=3.11
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+ Requires-Dist: jsonschema<5,>=4.23
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+ Requires-Dist: linkml<2,>=1.8
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+ Requires-Dist: pyyaml<7,>=6.0
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+ Provides-Extra: dev
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+ Requires-Dist: pytest<9,>=8; extra == 'dev'
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+ Description-Content-Type: text/markdown
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+
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+ # BioAI Evidence Validator
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+
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+ [![CI](https://github.com/NingyuSUN/bioai-evidence-validator/actions/workflows/ci.yml/badge.svg)](https://github.com/NingyuSUN/bioai-evidence-validator/actions/workflows/ci.yml)
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+ [![PyPI](https://img.shields.io/pypi/v/bioai-evidence-validator)](https://pypi.org/project/bioai-evidence-validator/)
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+ [![Python 3.11+](https://img.shields.io/badge/python-3.11%2B-blue)](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/pyproject.toml)
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+ [![License: Apache-2.0](https://img.shields.io/badge/license-Apache--2.0-blue)](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/LICENSE)
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+
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+ **Stop AI-extracted biological claims from entering your knowledge base or
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+ training set before their evidence is good enough for that use.**
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+
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+ An LLM can turn a paper into a tidy `gene → associated_with → phenotype` record
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+ that passes every schema check. This toolkit asks the next question: *is the
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+ evidence behind it sufficient for the specific use you have in mind?* It checks
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+ evidence structure, provenance consistency, scope and human-review requirements,
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+ then returns an auditable **admitted / review_required / rejected** decision for
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+ each requested use.
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+
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+ ```bash
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+ pip install bioai-evidence-validator
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+ ```
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+
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+ ## 30-second example
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+
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+ The two records below are identical except for one field: how the supporting
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+ evidence was extracted.
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+
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+ ```diff
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+ "evidence_type": "publication_result",
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+ - "extraction_method": "llm_extraction",
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+ + "extraction_method": "manual_curation",
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+ ```
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+
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+ ```console
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+ $ bioevidence validate examples/literature_claim/llm_only.json --profile literature-claim
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+ ```
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+
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+ ```json
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+ {
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+ "overall_status": "review_required",
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+ "findings": [
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+ {
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+ "rule_id": "BEV008",
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+ "severity": "review",
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+ "message": "Required evidence type 'publication_result' comes only from LLM extraction.",
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+ "blocking_uses": ["research_summary"]
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+ }
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+ ],
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+ "use_decisions": [
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+ { "use": "research_summary", "admission_status": "review_required", "reason_codes": ["BEV008"] }
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+ ]
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+ }
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+ ```
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+
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+ The command exits with **2**, so a pipeline can route the record to a reviewer.
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+ The manually curated version (`examples/literature_claim/curated_association.json`)
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+ is `admitted` with exit code **0**. Every full report also records the input,
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+ schema and profile SHA-256 hashes and versions for audit.
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+
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+ ## Why not just JSON Schema or Pydantic?
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+
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+ A schema tells you a record is well formed. It cannot tell you whether the
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+ record is trustworthy enough for a particular purpose.
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+
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+ | | Schema validation | This validator |
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+ |---|:---:|:---:|
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+ | Record shape and types | ✅ | ✅ (LinkML) |
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+ | Different evidence rules per intended use (summary vs. KB vs. training) | — | ✅ |
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+ | Quality gate per required evidence type (LLM-only evidence cannot ride on unrelated manual evidence) | — | ✅ |
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+ | Provenance consistency (source hashes, resolved references, scope) | — | ✅ |
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+ | Human adjudications bound to a specific statement and use | — | ✅ |
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+ | Machine-readable audit report with hashes of input, schema and profile | — | ✅ |
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+
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+ On the real-data benchmark below, schema-only checks admitted **160/160**
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+ injected faults; the full validator admitted **0/160**.
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+
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+ ## Use it
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+
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+ ### Command line
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+
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+ ```bash
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+ bioevidence profiles # list built-in profiles and their use contracts
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+ bioevidence validate record.json --profile literature-claim
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+ bioevidence validate record.json --profile my_profile.yaml --output report.json
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+ bioevidence generate-schema --output record.schema.json # JSON Schema for the input format
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+ ```
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+
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+ Exit codes: **0** admitted, **1** rejected, **2** review required, **3** input or configuration error.
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+
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+ ### Python
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+
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+ ```python
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+ import json
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+ from pathlib import Path
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+
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+ from bioevidence_validator.engine import validate_record
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+
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+ record = json.loads(Path("record.json").read_text(encoding="utf-8"))
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+ report = validate_record(record, profile="literature-claim")
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+
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+ for decision in report["use_decisions"]:
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+ print(decision["use"], decision["admission_status"], decision["reason_codes"])
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+ ```
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+
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+ `profile` accepts a built-in name or a path to your own YAML profile.
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+
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+ ## How it works
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+
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+ ```mermaid
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+ flowchart TD
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+ A["Structured evidence JSON"] --> B["LinkML structure checks"]
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+ B --> C["Reference and scope checks"]
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+ P["Selected YAML profile"] --> C
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+ C --> D["Evidence and human review requirements"]
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+ D --> E["Decision for each requested use"]
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+ E --> F["Audit report: findings, versions and hashes"]
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+ S["Frozen source evidence + intended use"] --> R["Independent human annotation"]
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+ R --> J["Resolve disagreements and record uncertainty"]
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+ J --> G["Freeze gold-standard test set"]
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+ G --> V["Compare held-out decisions with gold standard"]
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+ F --> V
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+ V --> M["False admission, false block and review rates"]
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+ ```
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+
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+ This diagram defines the complete project workflow. Each project supplies its own
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+ reviewed reference labels; the validator's decisions are evaluated against them.
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+ Gold labels stay separate from runtime evidence and rule development.
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+
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+ Domain rules are YAML profiles: new entity types, relations, evidence types and
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+ uses do not require engine edits.
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+
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+ | Example profile | Assertion | Use contract |
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+ |---|---|---|
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+ | `general` | Any typed entity–relation–entity statement | Provenance, scoped support, optional human review by use |
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+ | `literature-claim` | Gene/variant associated with phenotype/disease | Publication evidence; human acceptance for knowledge-base admission |
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+ | `dataset-label` | Sample assigned a label | Curated label plus sample link; human acceptance for training |
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+ | Custom YAML | Compound measured response in an assay | Assay evidence; defined without changing Python code |
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+
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+ See [Create a profile](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/docs/PROFILES.md).
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+
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+ ## Run the examples from source
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+
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+ Python 3.11+ and [uv](https://docs.astral.sh/uv/), from the repository root:
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+
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+ ```bash
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+ uv sync --frozen --extra dev
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+ uv run bioevidence profiles
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+ uv run bioevidence validate examples/general/curated_assertion.json
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+ uv run bioevidence validate examples/literature_claim/llm_only.json --profile literature-claim
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+ uv run bioevidence validate examples/custom_profile/assay_record.json --profile examples/custom_profile/assay.yaml
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+ uv run pytest
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+ ```
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+
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+ ## Build a gold standard for your project
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+
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+ 1. **Define the task:** specify the domain, intended uses, label definitions and evidence requirements in a written rubric.
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+ 2. **Select and freeze cases:** retain source versions and record hashes; group related entities and aliases into the same development/test split.
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+ 3. **Review independently:** domain reviewers label mapping correctness and use-specific admission without seeing validator predictions; record evidence and uncertainty.
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+ 4. **Resolve and version:** preserve original reviews, document disagreements and adjudication, then freeze the labels and provenance manifest.
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+ 5. **Evaluate:** compare held-out decisions with that reference; report false admissions, false blocks and review rates with counts and denominators.
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+
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+ Use the [annotation templates](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/evaluation/gold_standard/README.md) and
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+ [detailed protocol](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/docs/GOLD_STANDARD.md). Each gold standard is specific to a task,
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+ source version and intended use. Document reviewer roles and whether labels are
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+ single-reviewed or independently reviewed by multiple people.
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+
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+ ## Real-data case
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+
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+ [VBO canine name mapping](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/examples/vbo_canine/README.md) uses a frozen public ontology:
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+ 72 real-name cases, 160 controlled errors, and 16 separately reported trust-boundary
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+ cases. It compares schema-only checks, the previous aggregate quality gate, and
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+ per-required-evidence-type validation. Source-derived labels are not expert annotations.
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+
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+ ```bash
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+ uv run python examples/vbo_canine/run.py --output artifacts/vbo-canine
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+ ```
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+
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+ ### Benchmark results (v0.4.1)
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+
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+ ![VBO canine benchmark comparing false admissions across three validation methods](https://raw.githubusercontent.com/NingyuSUN/bioai-evidence-validator/main/docs/assets/vbo_canine_benchmark.svg)
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+
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+ On 72 real-source name mappings, the full validator admitted all 48 unambiguous cases and blocked automatic admission of all 24 ambiguous names (0/48 false blocks; 0/24 false admissions). Across 160 deliberately injected faults, false admissions were 160/160 for schema-only, 64/160 for the aggregate-quality ablation, and 0/160 for the full validator; the full validator sent 80 cases to review and rejected 80. All three methods admitted 16/16 falsified-target trust-boundary cases, showing the need for trustworthy source ingestion and supplied metadata.
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+
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+ **Interpretation limits:** Reference labels are derived from the pinned VBO source and authored fault specifications, not independent expert annotations. The 160 mutations share 16 seed cases and are correlated. This benchmark tests the mapping contract and controlled fault detection; it does not estimate biological accuracy or production error rates. See the [protocol and full results](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/examples/vbo_canine/README.md) and [machine-readable summary](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/examples/vbo_canine/results/summary.json).
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+
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+ ## Scope
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+
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+ The VBO case uses attributed public data; other fixtures are synthetic.
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+ Admission means **the supplied record meets the selected
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+ profile**, not that a biological claim is true. The toolkit does not retrieve papers,
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+ verify reviewer identities, train models, or measure prediction accuracy. The generic core compares supplied hashes; the VBO importer also hashes its local source
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+ projection. External source truth and cohort independence require upstream verification.
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+
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+ ## Versions and branches
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+
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+ `main` is the domain-neutral framework (0.4.1). The complete canine implementation
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+ and SQLite adapter from 0.3 live on the
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+ [`canine-breed` branch](https://github.com/NingyuSUN/bioai-evidence-validator/tree/canine-breed);
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+ see the [0.4 migration guide](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/docs/MIGRATION-0.4.md) and
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+ [changelog](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/CHANGELOG.md).
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+
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+ ## Citing
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+
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+ If you use this toolkit in research, please cite it using the metadata in
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+ [`CITATION.cff`](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/CITATION.cff)
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+ (GitHub's "Cite this repository" button generates APA and BibTeX).
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+
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+ [Create a profile](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/docs/PROFILES.md) ·
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+ [Engineering contract](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/docs/ENGINEERING.md) ·
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+ [Design case study](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/docs/CASE_STUDY.md) ·
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+ [Architecture decision](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/docs/ADR-002-domain-neutral-main.md) ·
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+ [Apache-2.0](https://github.com/NingyuSUN/bioai-evidence-validator/blob/main/LICENSE)
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+ bioai_evidence_validator-0.4.1.dist-info/RECORD,,
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+ Wheel-Version: 1.0
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+ Generator: hatchling 1.32.4
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+ Root-Is-Purelib: true
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+ Tag: py3-none-any
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+ [console_scripts]
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+ bioevidence = bioevidence_validator.cli:main
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+ negligent acts) or agreed to in writing, shall any Contributor be
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+ liable to You for damages, including any direct, indirect, special,
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+ incidental, or consequential damages of any character arising as a
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+ result of this License or out of the use or inability to use the
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+ Work (including but not limited to damages for loss of goodwill,
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+ work stoppage, computer failure or malfunction, or any and all
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+ other commercial damages or losses), even if such Contributor
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+ has been advised of the possibility of such damages.
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+
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+ 9. Accepting Warranty or Additional Liability. While redistributing
167
+ the Work or Derivative Works thereof, You may choose to offer,
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+ and charge a fee for, acceptance of support, warranty, indemnity,
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+ or other liability obligations and/or rights consistent with this
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+ License. However, in accepting such obligations, You may act only
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+ on Your own behalf and on Your sole responsibility, not on behalf
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+ of any other Contributor, and only if You agree to indemnify,
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+ defend, and hold each Contributor harmless for any liability
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+ incurred by, or claims asserted against, such Contributor by reason
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+ of your accepting any such warranty or additional liability.
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+
177
+ END OF TERMS AND CONDITIONS
178
+
179
+ APPENDIX: How to apply the Apache License to your work.
180
+
181
+ To apply the Apache License to your work, attach the following
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+ boilerplate notice, with the fields enclosed by brackets "[]"
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+ replaced with your own identifying information. (Don't include
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+ the brackets!) The text should be enclosed in the appropriate
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+ comment syntax for the file format. We also recommend that a
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+ file or class name and description of purpose be included on the
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+ same "printed page" as the copyright notice for easier
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+ identification within third-party archives.
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+
190
+ Copyright [yyyy] [name of copyright owner]
191
+
192
+ Licensed under the Apache License, Version 2.0 (the "License");
193
+ you may not use this file except in compliance with the License.
194
+ You may obtain a copy of the License at
195
+
196
+ http://www.apache.org/licenses/LICENSE-2.0
197
+
198
+ Unless required by applicable law or agreed to in writing, software
199
+ distributed under the License is distributed on an "AS IS" BASIS,
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+ WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
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+ See the License for the specific language governing permissions and
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+ limitations under the License.
@@ -0,0 +1,3 @@
1
+ """Evidence validation primitives and domain policy runners."""
2
+
3
+ __version__ = "0.4.1"
@@ -0,0 +1,114 @@
1
+ from __future__ import annotations
2
+
3
+ import argparse
4
+ import json
5
+ import os
6
+ import sys
7
+ import tempfile
8
+ from pathlib import Path
9
+
10
+ import yaml
11
+
12
+ from .engine import default_schema_path, generate_json_schema, validate_record, profile_path, list_profiles
13
+
14
+
15
+ def parser() -> argparse.ArgumentParser:
16
+ result = argparse.ArgumentParser(prog="bioevidence")
17
+ commands = result.add_subparsers(dest="command", required=True)
18
+ validate = commands.add_parser("validate", help="Validate one biological evidence record")
19
+ validate.add_argument("input", type=Path)
20
+ validate.add_argument("--output", type=Path)
21
+ validate.add_argument("--schema", type=Path, default=default_schema_path())
22
+ validate.add_argument("--profile", default="general", help="Built-in profile name or YAML file path")
23
+ generate = commands.add_parser("generate-schema", help="Generate JSON Schema from LinkML")
24
+ generate.add_argument("--output", type=Path, required=True)
25
+ generate.add_argument("--schema", type=Path, default=default_schema_path())
26
+ commands.add_parser("profiles", help="List built-in profiles and their use contracts")
27
+ return result
28
+
29
+
30
+ def _unique_object(pairs):
31
+ record = {}
32
+ for key, value in pairs:
33
+ if key in record:
34
+ raise ValueError(f"Duplicate JSON key: {key!r}")
35
+ record[key] = value
36
+ return record
37
+
38
+
39
+ def _invalid_constant(value):
40
+ raise ValueError(f"Non-finite JSON constant is not supported: {value}")
41
+
42
+
43
+ MAX_JSON_DEPTH = 100
44
+
45
+
46
+ def _check_depth(value) -> None:
47
+ """Reject over-nested input explicitly; the parser's own recursion limit varies by platform."""
48
+ stack = [(value, 1)]
49
+ while stack:
50
+ node, depth = stack.pop()
51
+ if depth > MAX_JSON_DEPTH:
52
+ raise ValueError(f"JSON nesting exceeds {MAX_JSON_DEPTH} levels")
53
+ children = node.values() if isinstance(node, dict) else node if isinstance(node, list) else ()
54
+ stack.extend((child, depth + 1) for child in children if isinstance(child, (dict, list)))
55
+
56
+
57
+ def _write_json(path: Path, value: dict) -> None:
58
+ """Replace the report only after the complete UTF-8 payload is written."""
59
+ payload = json.dumps(value, indent=2, allow_nan=False) + "\n"
60
+ path.parent.mkdir(parents=True, exist_ok=True)
61
+ temp_path = None
62
+ try:
63
+ with tempfile.NamedTemporaryFile(mode="w", encoding="utf-8", newline="\n",
64
+ dir=path.parent, delete=False) as handle:
65
+ temp_path = Path(handle.name)
66
+ handle.write(payload)
67
+ os.replace(temp_path, path)
68
+ finally:
69
+ if temp_path is not None:
70
+ temp_path.unlink(missing_ok=True)
71
+
72
+
73
+ def _run(args) -> int:
74
+ if args.command == "generate-schema":
75
+ if args.output.resolve() in {args.schema.resolve(), default_schema_path().resolve()}:
76
+ raise ValueError("Output must not overwrite the schema")
77
+ _write_json(args.output, generate_json_schema(args.schema))
78
+ return 0
79
+
80
+ if args.command == "profiles":
81
+ print(json.dumps(list_profiles(), indent=2))
82
+ return 0
83
+
84
+ selected_profile = profile_path(args.profile)
85
+ protected = [args.input, args.schema, selected_profile, default_schema_path()]
86
+ if args.output and args.output.resolve() in {p.resolve() for p in protected}:
87
+ raise ValueError("Output must not overwrite an input, schema, or profile")
88
+ record = json.loads(args.input.read_text(encoding="utf-8"),
89
+ object_pairs_hook=_unique_object, parse_constant=_invalid_constant)
90
+ _check_depth(record)
91
+ report = validate_record(record, schema_path=args.schema, profile=args.profile)
92
+ rendered = json.dumps(report, indent=2) + "\n"
93
+ if args.output:
94
+ _write_json(args.output, report)
95
+ else:
96
+ print(rendered, end="")
97
+ if report["overall_status"] == "rejected":
98
+ return 1
99
+ if report["overall_status"] == "review_required":
100
+ return 2
101
+ return 0
102
+
103
+
104
+ def main(argv: list[str] | None = None) -> int:
105
+ args = parser().parse_args(argv)
106
+ try:
107
+ return _run(args)
108
+ except (OSError, UnicodeError, ValueError, RecursionError, yaml.YAMLError) as exc:
109
+ print(json.dumps({"error": "input_or_execution_error", "message": str(exc)}), file=sys.stderr)
110
+ return 3
111
+
112
+
113
+ if __name__ == "__main__":
114
+ raise SystemExit(main())
@@ -0,0 +1,37 @@
1
+ """Strict configuration parsing shared by profile boundaries."""
2
+ from __future__ import annotations
3
+
4
+ import yaml
5
+
6
+
7
+ class UniqueKeyLoader(yaml.SafeLoader):
8
+ pass
9
+
10
+
11
+ def _mapping(loader, node, deep=False):
12
+ result = {}
13
+ for key_node, value_node in node.value:
14
+ key = loader.construct_object(key_node, deep=deep)
15
+ if not isinstance(key, str):
16
+ raise ValueError("Configuration keys must be strings")
17
+ if key in result:
18
+ raise ValueError(f"Duplicate YAML key: {key!r}")
19
+ result[key] = loader.construct_object(value_node, deep=deep)
20
+ return result
21
+
22
+
23
+ UniqueKeyLoader.add_constructor(yaml.resolver.BaseResolver.DEFAULT_MAPPING_TAG, _mapping)
24
+
25
+
26
+ def load_mapping(data: bytes, label: str) -> dict:
27
+ try:
28
+ value = yaml.load(data, Loader=UniqueKeyLoader)
29
+ except yaml.YAMLError as exc:
30
+ raise ValueError(f"Invalid {label} YAML: {exc}") from exc
31
+ if not isinstance(value, dict):
32
+ raise ValueError(f"{label} must be a mapping")
33
+ return value
34
+
35
+
36
+ def nonblank(value) -> bool:
37
+ return isinstance(value, str) and bool(value.strip())
@@ -0,0 +1,265 @@
1
+ from __future__ import annotations
2
+
3
+ import hashlib
4
+ import json
5
+ from dataclasses import asdict, dataclass
6
+ from datetime import datetime, timezone
7
+ from pathlib import Path
8
+ from typing import Any
9
+
10
+ from jsonschema import Draft202012Validator, FormatChecker
11
+ from linkml.generators.jsonschemagen import JsonSchemaGenerator
12
+
13
+ from . import __version__
14
+ from .config import load_mapping, nonblank
15
+
16
+
17
+ @dataclass(frozen=True)
18
+ class Finding:
19
+ rule_id: str
20
+ severity: str
21
+ message: str
22
+ field_path: str
23
+ blocking_uses: list[str]
24
+
25
+
26
+ def sha256_bytes(data: bytes) -> str:
27
+ return hashlib.sha256(data).hexdigest()
28
+
29
+
30
+ def _resource_path(kind: str, filename: str) -> Path:
31
+ return Path(__file__).resolve().parent / kind / filename
32
+
33
+
34
+ def default_schema_path() -> Path:
35
+ return _resource_path("schema", "bioevidence_core.yaml")
36
+
37
+
38
+ def generate_json_schema(schema_path: Path | None = None) -> dict[str, Any]:
39
+ schema_path = schema_path or default_schema_path()
40
+ try:
41
+ rendered = JsonSchemaGenerator(str(schema_path), mergeimports=True).serialize()
42
+ schema = json.loads(rendered)
43
+ Draft202012Validator.check_schema(schema)
44
+ return schema
45
+ except Exception as exc:
46
+ raise ValueError(f"Unable to compile LinkML schema: {exc}") from exc
47
+
48
+
49
+ def profile_path(profile: str | Path = "general") -> Path:
50
+ """Resolve a built-in name or an explicit YAML path; never silently fall back."""
51
+ if isinstance(profile, str) and profile in {"general", "literature-claim", "dataset-label"}:
52
+ return _resource_path("profiles", profile + ".yaml")
53
+ path = Path(profile)
54
+ if not path.is_file():
55
+ raise ValueError(f"Unknown profile or missing profile file: {profile}")
56
+ return path
57
+
58
+
59
+ def _string_list(value: Any) -> bool:
60
+ return (isinstance(value, list) and all(nonblank(x) for x in value)
61
+ and len(set(value)) == len(value))
62
+
63
+
64
+ def load_profile(data: bytes) -> dict[str, Any]:
65
+ profile = load_mapping(data, "Profile")
66
+ if set(profile) != {"id", "version", "description", "predicates", "subject_types", "object_types", "uses"}:
67
+ raise ValueError("Profile has missing or unknown fields")
68
+ if any(not nonblank(profile[k]) for k in ("id", "version", "description")):
69
+ raise ValueError("Profile id, version and description must be nonblank strings")
70
+ for key in ("predicates", "subject_types", "object_types"):
71
+ if not _string_list(profile[key]):
72
+ raise ValueError(f"Profile {key} must be a list of distinct nonblank strings")
73
+ if not isinstance(profile["uses"], dict) or not profile["uses"]:
74
+ raise ValueError("Profile uses must be a nonempty mapping")
75
+ flags = {"require_human_acceptance", "allow_llm_only", "allow_string_match_only"}
76
+ for name, use in profile["uses"].items():
77
+ if not nonblank(name) or not isinstance(use, dict) or set(use) != flags | {"required_evidence_types"}:
78
+ raise ValueError(f"Invalid or incomplete use configuration: {name!r}")
79
+ if any(type(use[key]) is not bool for key in flags) or not _string_list(use["required_evidence_types"]):
80
+ raise ValueError(f"Use {name!r} requires boolean flags and distinct evidence types")
81
+ return profile
82
+
83
+
84
+ def list_profiles() -> list[dict[str, Any]]:
85
+ return [load_profile(profile_path(name).read_bytes())
86
+ for name in ("general", "literature-claim", "dataset-label")]
87
+
88
+
89
+ def _schema_findings(record: Any, rendered: dict, uses: list[str]) -> list[Finding]:
90
+ validator = Draft202012Validator(rendered, format_checker=FormatChecker())
91
+ findings = []
92
+ for error in sorted(validator.iter_errors(record), key=lambda e: tuple(str(p) for p in e.absolute_path)):
93
+ path = "$" + "".join(f"[{p}]" if isinstance(p, int) else f".{p}" for p in error.absolute_path)
94
+ findings.append(Finding("SCHEMA", "error", error.message, path, uses))
95
+ return findings
96
+
97
+
98
+ def _integrity_findings(record: dict, profile: dict) -> list[Finding]:
99
+ findings = []
100
+ uses = record["requested_uses"]
101
+ statement = record["statement"]
102
+
103
+ def error(message, path):
104
+ findings.append(Finding("RECORD_INTEGRITY", "error", message, path, uses))
105
+
106
+ if record["profile_id"] != profile["id"]:
107
+ error("Record profile_id does not match the explicitly selected profile.", "$.profile_id")
108
+ if not _string_list(uses) or not uses or set(uses) - profile["uses"].keys():
109
+ error("requested_uses must contain distinct uses supported by the selected profile.", "$.requested_uses")
110
+ collections = [("$.source_artifacts", record["source_artifacts"]),
111
+ ("$.evidence_items", record["evidence_items"]),
112
+ ("$.statement.evidence_lines", statement["evidence_lines"]),
113
+ ("$.adjudications", record.get("adjudications") or [])]
114
+ for path, rows in collections:
115
+ identities = [row["id"] for row in rows]
116
+ if len(identities) != len(set(identities)):
117
+ error("Duplicate identifiers make references ambiguous.", path)
118
+ artifacts = {row["id"] for row in record["source_artifacts"]}
119
+ items = {row["id"] for row in record["evidence_items"]}
120
+ for index, item in enumerate(record["evidence_items"]):
121
+ if item["source_artifact_id"] not in artifacts:
122
+ error("Evidence references an absent source artifact.", f"$.evidence_items[{index}].source_artifact_id")
123
+ if not _string_list(item["scope"]):
124
+ error("Scope must contain distinct tokens.", f"$.evidence_items[{index}].scope")
125
+ if not _string_list(statement["scope"]):
126
+ error("Scope must contain distinct tokens.", "$.statement.scope")
127
+ for index, line in enumerate(statement["evidence_lines"]):
128
+ refs = line["evidence_item_ids"]
129
+ if not _string_list(refs) or set(refs) - items:
130
+ error("Evidence line has duplicate or unresolved item references.", f"$.statement.evidence_lines[{index}].evidence_item_ids")
131
+ for index, decision in enumerate(record.get("adjudications") or []):
132
+ if decision["statement_id"] != statement["id"]:
133
+ error("Adjudication targets a different statement.", f"$.adjudications[{index}].statement_id")
134
+ targets = decision["applies_to_uses"]
135
+ if not _string_list(targets) or set(targets) - profile["uses"].keys():
136
+ error("Adjudication uses must be distinct and supported by this profile.", f"$.adjudications[{index}].applies_to_uses")
137
+ return findings
138
+
139
+
140
+ def evaluate_profile(record: dict, profile: dict) -> list[Finding]:
141
+ """Fixed evidence checks plus declarative use contracts; no domain dispatch."""
142
+ findings = []
143
+ requested = record["requested_uses"]
144
+ statement = record["statement"]
145
+ items = {x["id"]: x for x in record["evidence_items"]}
146
+
147
+ def add(code, severity, message, path, uses=None):
148
+ findings.append(Finding(code, severity, message, path, requested if uses is None else uses))
149
+
150
+ if statement["statement_status"] in {"rejected", "superseded"}:
151
+ add("BEV001", "error", "A rejected or superseded statement is ineligible.", "$.statement.statement_status")
152
+ for index, source in enumerate(record["source_artifacts"]):
153
+ if source.get("observed_sha256") and source["observed_sha256"] != source["sha256"]:
154
+ add("BEV002", "error", "Observed source hash differs from the frozen hash.", f"$.source_artifacts[{index}].observed_sha256")
155
+ for key, value, path in [("predicates", statement["predicate"], "$.statement.predicate"),
156
+ ("subject_types", statement["subject"]["entity_type"], "$.statement.subject.entity_type"),
157
+ ("object_types", statement["object"]["entity_type"], "$.statement.object.entity_type")]:
158
+ if profile[key] and value not in profile[key]:
159
+ add("BEV003", "error", f"Value is outside the profile's allowed {key}.", path)
160
+ supporting = {}
161
+ for index, line in enumerate(statement["evidence_lines"]):
162
+ if line["direction"] == "contradicts":
163
+ add("BEV004", "review", "Contradicting evidence remains unresolved.", f"$.statement.evidence_lines[{index}]")
164
+ if line["direction"] == "supports":
165
+ for item_id in line["evidence_item_ids"]:
166
+ item = items[item_id]
167
+ if set(item["scope"]) != set(statement["scope"]):
168
+ add("BEV005", "error", "Supporting evidence scope must match the statement's explicit scope tokens.", f"$.statement.evidence_lines[{index}]")
169
+ else:
170
+ supporting[item_id] = item
171
+ if not supporting:
172
+ add("BEV006", "review", "No resolved, scope-matched supporting evidence.", "$.statement.evidence_lines")
173
+ types = {item["evidence_type"] for item in supporting.values()}
174
+ decisions = record.get("adjudications") or []
175
+ for use in requested:
176
+ contract = profile["uses"][use]
177
+ missing = set(contract["required_evidence_types"]) - types
178
+ if missing:
179
+ add("BEV007", "error", "Missing supporting evidence types: " + ", ".join(sorted(missing)), "$.evidence_items", [use])
180
+ # Each required evidence type must independently satisfy the quality gate.
181
+ # An unrelated manually curated note cannot strengthen a required LLM result.
182
+ groups = [(kind, [item for item in supporting.values() if item["evidence_type"] == kind])
183
+ for kind in contract["required_evidence_types"]]
184
+ if not groups:
185
+ groups = [(None, list(supporting.values()))]
186
+ for kind, evidence in groups:
187
+ methods = {item["extraction_method"] for item in evidence}
188
+ context = f"Required evidence type {kind!r}" if kind is not None else "Supporting evidence"
189
+ if methods == {"llm_extraction"} and not contract["allow_llm_only"]:
190
+ add("BEV008", "review", context + " comes only from LLM extraction.", "$.evidence_items", [use])
191
+ if methods == {"normalized_string_match"} and not contract["allow_string_match_only"]:
192
+ add("BEV009", "review", context + " comes only from normalized string matching.", "$.evidence_items", [use])
193
+ if len(methods) > 1 and methods <= {"llm_extraction", "normalized_string_match"}:
194
+ if not (contract["allow_llm_only"] and contract["allow_string_match_only"]):
195
+ add("BEV013", "review", context + " mixes only LLM extraction and string matching.", "$.evidence_items", [use])
196
+ human = {d["decision"] for d in decisions if d["reviewer"]["agent_type"] == "human" and use in d["applies_to_uses"]}
197
+ if contract["require_human_acceptance"] and "accept" not in human:
198
+ add("BEV010", "error", "This use requires explicit human acceptance.", "$.adjudications", [use])
199
+ if "reject" in human:
200
+ add("BEV011", "error", "Human rejection remains present for this use.", "$.adjudications", [use])
201
+ if "defer" in human:
202
+ add("BEV012", "review", "A human decision is deferred for this use.", "$.adjudications", [use])
203
+ return findings
204
+
205
+
206
+ def decide_uses(requested_uses: list[str], findings: list[Finding]) -> list[dict[str, Any]]:
207
+ decisions = []
208
+ for use in requested_uses:
209
+ relevant = [f for f in findings if f.rule_id in {"SCHEMA", "RECORD_INTEGRITY"} or use in f.blocking_uses]
210
+ status = ("rejected" if any(f.severity == "error" for f in relevant) else
211
+ "review_required" if any(f.severity == "review" for f in relevant) else "admitted")
212
+ decisions.append({"use": use, "admission_status": status, "reason_codes": sorted({f.rule_id for f in relevant})})
213
+ return decisions
214
+
215
+
216
+ class RecordValidator:
217
+ """Snapshot a profile and compile schemas once for a consistent batch.
218
+
219
+ A trusted custom LinkML schema may add constraints; baseline checks always run.
220
+ Source bytes and reviewer identities are supplied assertions, not authenticated here.
221
+ """
222
+ def __init__(self, *, profile: str | Path = "general", schema_path: Path | None = None):
223
+ profile_bytes = profile_path(profile).read_bytes()
224
+ self._profile = load_profile(profile_bytes)
225
+ self.profile_sha256 = sha256_bytes(profile_bytes)
226
+ baseline = default_schema_path().resolve()
227
+ selected = Path(schema_path or baseline).resolve()
228
+ paths = [baseline] if selected == baseline else [baseline, selected]
229
+ self._schemas = [generate_json_schema(path) for path in paths]
230
+ versions = [str(load_mapping(path.read_bytes(), "Schema").get("version", "unknown")) for path in paths]
231
+ self.schema_version = versions[-1]
232
+ self.schema_sources = [{"role": "baseline" if i == 0 else "extension", "version": versions[i],
233
+ "sha256": sha256_bytes(json.dumps(schema, sort_keys=True, separators=(",", ":")).encode())}
234
+ for i, schema in enumerate(self._schemas)]
235
+ self.schema_sha256 = (self.schema_sources[0]["sha256"] if len(paths) == 1 else
236
+ sha256_bytes(json.dumps(self._schemas, sort_keys=True, separators=(",", ":")).encode()))
237
+
238
+ def validate(self, record: Any) -> dict[str, Any]:
239
+ canonical = json.dumps(record, sort_keys=True, separators=(",", ":"), allow_nan=False).encode()
240
+ requested = record.get("requested_uses") if isinstance(record, dict) else None
241
+ uses = list(dict.fromkeys(use for use in requested if isinstance(use, str))) if isinstance(requested, list) else []
242
+ findings = []
243
+ for rendered in self._schemas:
244
+ findings.extend(_schema_findings(record, rendered, uses))
245
+ if not findings:
246
+ findings.extend(_integrity_findings(record, self._profile))
247
+ if not findings:
248
+ findings.extend(evaluate_profile(record, self._profile))
249
+ decisions = decide_uses(uses, findings)
250
+ overall = ("rejected" if not decisions or any(f.severity == "error" for f in findings) else
251
+ "review_required" if any(x["admission_status"] == "review_required" for x in decisions) else "admitted")
252
+ return {
253
+ "validator": "bioai-evidence-validator", "validator_version": __version__,
254
+ "profile_id": self._profile["id"], "profile_version": self._profile["version"],
255
+ "profile_sha256": self.profile_sha256,
256
+ "schema_version": self.schema_version, "schema_sha256": self.schema_sha256,
257
+ "schema_sources": [dict(source) for source in self.schema_sources],
258
+ "input_sha256": sha256_bytes(canonical), "validated_at": datetime.now(timezone.utc).isoformat(),
259
+ "schema_valid": not any(f.rule_id == "SCHEMA" for f in findings),
260
+ "overall_status": overall, "findings": [asdict(f) for f in findings], "use_decisions": decisions,
261
+ }
262
+
263
+
264
+ def validate_record(record: Any, *, profile: str | Path = "general", schema_path: Path | None = None) -> dict[str, Any]:
265
+ return RecordValidator(profile=profile, schema_path=schema_path).validate(record)
@@ -0,0 +1,35 @@
1
+ id: dataset-label
2
+ version: 0.4.1
3
+ description: Dataset label evidence and sample-link review; supplied metadata does
4
+ not prove biological membership.
5
+ predicates:
6
+ - has_label
7
+ subject_types:
8
+ - sample
9
+ object_types:
10
+ - cell_type
11
+ - phenotype
12
+ - class_label
13
+ uses:
14
+ reference_annotation:
15
+ required_evidence_types:
16
+ - curated_label
17
+ - sample_link
18
+ require_human_acceptance: false
19
+ allow_llm_only: false
20
+ allow_string_match_only: false
21
+ training_data:
22
+ required_evidence_types:
23
+ - curated_label
24
+ - sample_link
25
+ require_human_acceptance: true
26
+ allow_llm_only: false
27
+ allow_string_match_only: false
28
+ external_validation:
29
+ required_evidence_types:
30
+ - curated_label
31
+ - sample_link
32
+ - independent_cohort_review
33
+ require_human_acceptance: true
34
+ allow_llm_only: false
35
+ allow_string_match_only: false
@@ -0,0 +1,28 @@
1
+ id: general
2
+ version: 0.4.1
3
+ description: General provenance, evidence scope and use admission; no biological domain
4
+ assumptions.
5
+ predicates: []
6
+ subject_types: []
7
+ object_types: []
8
+ uses:
9
+ knowledge_base:
10
+ required_evidence_types: []
11
+ require_human_acceptance: false
12
+ allow_llm_only: false
13
+ allow_string_match_only: false
14
+ research_summary:
15
+ required_evidence_types: []
16
+ require_human_acceptance: false
17
+ allow_llm_only: false
18
+ allow_string_match_only: false
19
+ training_data:
20
+ required_evidence_types: []
21
+ require_human_acceptance: true
22
+ allow_llm_only: false
23
+ allow_string_match_only: false
24
+ external_validation:
25
+ required_evidence_types: []
26
+ require_human_acceptance: true
27
+ allow_llm_only: false
28
+ allow_string_match_only: false
@@ -0,0 +1,26 @@
1
+ id: literature-claim
2
+ version: 0.4.1
3
+ description: Synthetic gene/phenotype literature-claim curation example, not a clinical
4
+ interpretation guideline.
5
+ predicates:
6
+ - associated_with
7
+ - contributes_to
8
+ subject_types:
9
+ - gene
10
+ - variant
11
+ object_types:
12
+ - phenotype
13
+ - disease
14
+ uses:
15
+ research_summary:
16
+ required_evidence_types:
17
+ - publication_result
18
+ require_human_acceptance: false
19
+ allow_llm_only: false
20
+ allow_string_match_only: false
21
+ knowledge_base:
22
+ required_evidence_types:
23
+ - publication_result
24
+ require_human_acceptance: true
25
+ allow_llm_only: false
26
+ allow_string_match_only: false
@@ -0,0 +1,336 @@
1
+ id: https://w3id.org/bioevidence/core
2
+ name: bioevidence_core
3
+ title: BioEvidence operational core
4
+ description: Domain-neutral evidence records for biological assertions, source provenance,
5
+ scoped adjudication, and use-specific admission.
6
+ license: Apache-2.0
7
+ version: 0.4.0
8
+ prefixes:
9
+ bioev: https://w3id.org/bioevidence/
10
+ linkml: https://w3id.org/linkml/
11
+ prov: http://www.w3.org/ns/prov#
12
+ sepio: http://purl.obolibrary.org/obo/SEPIO_
13
+ default_prefix: bioev
14
+ default_range: string
15
+ imports:
16
+ - linkml:types
17
+ enums:
18
+ AgentType:
19
+ permissible_values:
20
+ human: null
21
+ software: null
22
+ organization: null
23
+ SourceType:
24
+ permissible_values:
25
+ ontology_snapshot: null
26
+ registry_snapshot: null
27
+ dataset_snapshot: null
28
+ publication: null
29
+ web_page: null
30
+ local_file: null
31
+ EvidenceDirection:
32
+ permissible_values:
33
+ supports: null
34
+ contradicts: null
35
+ neutral: null
36
+ ExtractionMethod:
37
+ permissible_values:
38
+ deterministic_parser: null
39
+ manual_curation: null
40
+ normalized_string_match: null
41
+ llm_extraction: null
42
+ StatementStatus:
43
+ permissible_values:
44
+ proposed: null
45
+ accepted: null
46
+ rejected: null
47
+ superseded: null
48
+ AdjudicationDecision:
49
+ permissible_values:
50
+ accept: null
51
+ reject: null
52
+ defer: null
53
+ FindingSeverity:
54
+ permissible_values:
55
+ error: null
56
+ review: null
57
+ warning: null
58
+ AdmissionStatus:
59
+ permissible_values:
60
+ admitted: null
61
+ review_required: null
62
+ rejected: null
63
+ not_evaluated: null
64
+ slots:
65
+ id:
66
+ pattern: \S
67
+ identifier: true
68
+ range: uriorcurie
69
+ required: true
70
+ name:
71
+ range: string
72
+ agent_type:
73
+ range: AgentType
74
+ required: true
75
+ title:
76
+ pattern: \S
77
+ range: string
78
+ required: true
79
+ source_type:
80
+ range: SourceType
81
+ required: true
82
+ uri:
83
+ range: uri
84
+ version:
85
+ pattern: \S
86
+ range: string
87
+ required: true
88
+ retrieved_at:
89
+ range: datetime
90
+ required: true
91
+ sha256:
92
+ range: string
93
+ pattern: ^[0-9a-f]{64}$
94
+ required: true
95
+ observed_sha256:
96
+ range: string
97
+ pattern: ^[0-9a-f]{64}$
98
+ source_artifact_id:
99
+ pattern: \S
100
+ range: uriorcurie
101
+ required: true
102
+ locator:
103
+ pattern: \S
104
+ range: string
105
+ required: true
106
+ extracted_text:
107
+ range: string
108
+ evidence_type:
109
+ pattern: \S
110
+ range: string
111
+ required: true
112
+ extraction_method:
113
+ range: ExtractionMethod
114
+ required: true
115
+ created_by:
116
+ range: Agent
117
+ inlined: true
118
+ evidence_item_ids:
119
+ pattern: \S
120
+ required: true
121
+ range: uriorcurie
122
+ multivalued: true
123
+ minimum_cardinality: 1
124
+ direction:
125
+ range: EvidenceDirection
126
+ required: true
127
+ rationale:
128
+ pattern: \S
129
+ range: string
130
+ evidence_lines:
131
+ required: true
132
+ range: EvidenceLine
133
+ multivalued: true
134
+ inlined: true
135
+ inlined_as_list: true
136
+ minimum_cardinality: 1
137
+ statement_status:
138
+ range: StatementStatus
139
+ required: true
140
+ decision:
141
+ range: AdjudicationDecision
142
+ required: true
143
+ reviewer:
144
+ range: Agent
145
+ inlined: true
146
+ required: true
147
+ decided_at:
148
+ range: datetime
149
+ required: true
150
+ rule_id:
151
+ range: string
152
+ required: true
153
+ severity:
154
+ range: FindingSeverity
155
+ required: true
156
+ message:
157
+ range: string
158
+ required: true
159
+ field_path:
160
+ range: string
161
+ blocking_uses:
162
+ range: string
163
+ multivalued: true
164
+ use:
165
+ range: string
166
+ required: true
167
+ admission_status:
168
+ range: AdmissionStatus
169
+ required: true
170
+ reason_codes:
171
+ range: string
172
+ multivalued: true
173
+ record_id:
174
+ identifier: true
175
+ range: string
176
+ pattern: \S
177
+ required: true
178
+ profile_id:
179
+ range: string
180
+ pattern: \S
181
+ required: true
182
+ statement:
183
+ range: Statement
184
+ inlined: true
185
+ required: true
186
+ source_artifacts:
187
+ range: SourceArtifact
188
+ inlined: true
189
+ required: true
190
+ multivalued: true
191
+ inlined_as_list: true
192
+ minimum_cardinality: 1
193
+ evidence_items:
194
+ range: EvidenceItem
195
+ inlined: true
196
+ required: true
197
+ multivalued: true
198
+ inlined_as_list: true
199
+ minimum_cardinality: 1
200
+ adjudications:
201
+ range: Adjudication
202
+ inlined: true
203
+ multivalued: true
204
+ inlined_as_list: true
205
+ minimum_cardinality: 0
206
+ requested_uses:
207
+ range: string
208
+ pattern: \S
209
+ required: true
210
+ multivalued: true
211
+ minimum_cardinality: 1
212
+ subject:
213
+ range: Entity
214
+ inlined: true
215
+ required: true
216
+ object:
217
+ range: Entity
218
+ inlined: true
219
+ required: true
220
+ label:
221
+ range: string
222
+ pattern: \S
223
+ required: true
224
+ entity_type:
225
+ range: string
226
+ pattern: \S
227
+ required: true
228
+ predicate:
229
+ range: string
230
+ pattern: \S
231
+ required: true
232
+ scope:
233
+ range: string
234
+ pattern: \S
235
+ required: true
236
+ multivalued: true
237
+ minimum_cardinality: 1
238
+ statement_id:
239
+ range: string
240
+ pattern: \S
241
+ required: true
242
+ applies_to_uses:
243
+ range: string
244
+ pattern: \S
245
+ required: true
246
+ multivalued: true
247
+ minimum_cardinality: 1
248
+ classes:
249
+ Agent:
250
+ class_uri: prov:Agent
251
+ slots:
252
+ - id
253
+ - name
254
+ - agent_type
255
+ SourceArtifact:
256
+ description: Immutable description of the exact source bytes used by a decision.
257
+ class_uri: prov:Entity
258
+ slots:
259
+ - id
260
+ - title
261
+ - source_type
262
+ - uri
263
+ - version
264
+ - retrieved_at
265
+ - sha256
266
+ - observed_sha256
267
+ EvidenceItem:
268
+ description: A located, typed unit of evidence extracted from one source artifact.
269
+ slots:
270
+ - id
271
+ - source_artifact_id
272
+ - locator
273
+ - extracted_text
274
+ - evidence_type
275
+ - extraction_method
276
+ - created_by
277
+ - scope
278
+ EvidenceLine:
279
+ description: An explicit supporting, contradicting, or neutral evidence relationship.
280
+ slots:
281
+ - id
282
+ - direction
283
+ - evidence_item_ids
284
+ - rationale
285
+ Statement:
286
+ slots:
287
+ - id
288
+ - subject
289
+ - predicate
290
+ - object
291
+ - scope
292
+ - evidence_lines
293
+ - statement_status
294
+ - created_by
295
+ Adjudication:
296
+ description: A human decision that never overwrites the underlying evidence or
297
+ findings.
298
+ slots:
299
+ - id
300
+ - statement_id
301
+ - applies_to_uses
302
+ - decision
303
+ - reviewer
304
+ - rationale
305
+ - decided_at
306
+ slot_usage:
307
+ rationale:
308
+ required: true
309
+ Finding:
310
+ slots:
311
+ - rule_id
312
+ - severity
313
+ - message
314
+ - field_path
315
+ - blocking_uses
316
+ UseDecision:
317
+ slots:
318
+ - use
319
+ - admission_status
320
+ - reason_codes
321
+ Entity:
322
+ description: A domain entity with caller-supplied stable identity and type.
323
+ slots:
324
+ - id
325
+ - label
326
+ - entity_type
327
+ BioEvidenceRecord:
328
+ tree_root: true
329
+ slots:
330
+ - record_id
331
+ - profile_id
332
+ - statement
333
+ - source_artifacts
334
+ - evidence_items
335
+ - adjudications
336
+ - requested_uses