M3Drop 0.4.42__py3-none-any.whl → 0.4.45__py3-none-any.whl

m3Drop/DiagnosticsGPU.py

@@ -0,0 +1,420 @@
+import numpy as np
+import pandas as pd
+import cupy as cp
+import cupyx.scipy.sparse as csp
+import matplotlib.pyplot as plt
+import h5py
+import os
+import time
+import pickle
+import psutil
+import gc
+from scipy import sparse
+from scipy import stats
+import anndata
+
+from .ControlDeviceGPU import ControlDevice
+from .CoreGPU import (
+    hidden_calc_valsGPU, 
+    NBumiFitModelGPU, 
+    NBumiFitDispVsMeanGPU, 
+    dropout_prob_kernel
+)
+
+from cupy.sparse import csr_matrix as cp_csr_matrix
+import scipy.sparse as sp
+from scipy.sparse import csr_matrix as sp_csr_matrix
+
+import statsmodels.api as sm
+from scipy.stats import norm
+from statsmodels.stats.multitest import multipletests
+
+# ==========================================
+#        DIAGNOSTICS & COMPARISON
+# ==========================================
+
+def NBumiFitBasicModelGPU(
+    filename: str,
+    stats: dict,
+    mask_filename: str = None, 
+    mode: str = "auto",
+    manual_target: int = 3000,
+    phase_label: str = "Phase [1/1]",
+    desc_label: str = None  # [UI FIX] Added for delayed printing
+) -> dict:
+    """
+    Fits the Basic Model by calculating Normalized Variance ON-THE-FLY.
+    STRICT FLOAT64 ENFORCEMENT.
+    """
+    # 1. Get Raw Dimensions & Setup ControlDevice
+    with h5py.File(filename, 'r') as f:
+        indptr_cpu = f['X']['indptr'][:]
+        total_rows = len(indptr_cpu) - 1
+        raw_ng = f['X'].attrs['shape'][1] 
+
+    device = ControlDevice(
+        indptr=indptr_cpu, 
+        total_rows=total_rows, 
+        n_genes=raw_ng, 
+        mode=mode, 
+        manual_target=manual_target
+    )
+    nc = device.total_rows
+
+    # [UI FIX] Print description AFTER ControlDevice box
+    if desc_label:
+        print(f"{phase_label}: {desc_label}")
+
+    # 2. Load Mask
+    if mask_filename and os.path.exists(mask_filename):
+        with open(mask_filename, 'rb') as f:
+            mask_cpu = pickle.load(f)
+    else:
+        mask_cpu = np.ones(raw_ng, dtype=bool)
+
+    filtered_ng = int(np.sum(mask_cpu))
+    
+    # 3. Pre-calculate Size Factors
+    cell_sums = stats['tis'].values
+    median_sum = np.median(cell_sums[cell_sums > 0])
+    # [FLOAT64] Explicitly utilizing float64 for size factors
+    size_factors = np.ones_like(cell_sums, dtype=np.float64)
+    non_zero_mask = cell_sums > 0
+    size_factors[non_zero_mask] = cell_sums[non_zero_mask] / median_sum
+    
+    # 4. Init GPU Arrays
+    sum_norm_x_gpu = cp.zeros(filtered_ng, dtype=cp.float64)
+    sum_norm_sq_gpu = cp.zeros(filtered_ng, dtype=cp.float64)
+
+    with h5py.File(filename, 'r') as f_in:
+        h5_indptr = f_in['X']['indptr']
+        h5_data = f_in['X']['data']
+        h5_indices = f_in['X']['indices']
+
+        current_row = 0
+        while current_row < nc:
+            end_row = device.get_next_chunk(current_row, mode='dense', overhead_multiplier=1.5)
+            if end_row is None or end_row <= current_row: break
+
+            chunk_size = end_row - current_row
+            # [UI] Phase-aware progress bar
+            print(f"{phase_label}: Processing {end_row} of {nc} | Chunk: {chunk_size}", end='\r')
+
+            start_idx, end_idx = h5_indptr[current_row], h5_indptr[end_row]
+            if start_idx == end_idx:
+                current_row = end_row
+                continue
+            
+            # [FLOAT64] Load Raw Chunk as float64
+            data_gpu = cp.asarray(h5_data[start_idx:end_idx], dtype=cp.float64)
+            indices_gpu = cp.asarray(h5_indices[start_idx:end_idx])
+            indptr_gpu = cp.asarray(h5_indptr[current_row:end_row+1] - h5_indptr[current_row])
+            
+            # Reconstruct CSR & Filter
+            raw_chunk = cp_csr_matrix((data_gpu, indices_gpu, indptr_gpu), shape=(chunk_size, raw_ng))
+            mask_gpu = cp.asarray(mask_cpu)
+            filtered_chunk = raw_chunk[:, mask_gpu]
+
+            # Fused Normalization
+            # [FLOAT64] Size factors are already float64
+            sf_chunk = cp.asarray(size_factors[current_row:end_row], dtype=cp.float64)
+            recip_sf = 1.0 / sf_chunk
+            D = csp.diags(recip_sf)
+            norm_chunk = D.dot(filtered_chunk)
+            norm_chunk.data = cp.round(norm_chunk.data)
+            
+            # Accumulate
+            sum_norm_x_gpu += norm_chunk.sum(axis=0).ravel()
+            norm_chunk.data **= 2
+            sum_norm_sq_gpu += norm_chunk.sum(axis=0).ravel()
+            
+            del data_gpu, indices_gpu, raw_chunk, filtered_chunk, norm_chunk, D, sf_chunk, mask_gpu
+            cp.get_default_memory_pool().free_all_blocks()
+            current_row = end_row
+
+    # Final Calculations
+    mean_norm_gpu = sum_norm_x_gpu / nc
+    mean_sq_norm_gpu = sum_norm_sq_gpu / nc
+    var_norm_gpu = mean_sq_norm_gpu - (mean_norm_gpu ** 2)
+    
+    denom_gpu = var_norm_gpu - mean_norm_gpu
+    size_gpu = cp.full(filtered_ng, 1000.0, dtype=cp.float64)
+    valid_mask = denom_gpu > 1e-6
+    size_gpu[valid_mask] = mean_norm_gpu[valid_mask]**2 / denom_gpu[valid_mask]
+    
+    max_size_val = cp.nanmax(size_gpu[size_gpu < 1e6]) * 10
+    if cp.isnan(max_size_val) or max_size_val == 0: max_size_val = 1000.0
+    size_gpu[cp.isnan(size_gpu) | (size_gpu <= 0)] = max_size_val
+    size_gpu[size_gpu < 1e-10] = 1e-10
+    
+    # [UI] Clean completion - Force Newline
+    print("") 
+    print(f"{phase_label}: COMPLETE")
+
+    return {
+        'var_obs': pd.Series(var_norm_gpu.get(), index=stats['tjs'].index),
+        'sizes': pd.Series(size_gpu.get(), index=stats['tjs'].index),
+        'vals': stats 
+    }
+
+def NBumiCheckFitFSGPU(
+    filename: str,
+    fit: dict,
+    mode: str = "auto",
+    manual_target: int = 3000,
+    suppress_plot=False,
+    plot_filename=None,
+    phase_label="Phase [1/1]",
+    desc_label: str = None  # [UI FIX] Added for delayed printing
+) -> dict:
+    """
+    Calculates expected dropouts. Handles Real and Virtual Populations.
+    Uses FUSED KERNEL to prevent OOM on large chunks.
+    """
+    vals = fit['vals']
+    ng = vals['ng']
+    
+    with h5py.File(filename, 'r') as f:
+        indptr_cpu = f['X']['indptr'][:]
+        total_rows = len(indptr_cpu) - 1
+    
+    device = ControlDevice(
+        indptr=indptr_cpu, 
+        total_rows=total_rows, 
+        n_genes=ng, 
+        mode=mode, 
+        manual_target=manual_target
+    )
+    nc = device.total_rows
+
+    # [UI FIX] Print description AFTER ControlDevice box
+    if desc_label:
+        print(f"{phase_label}: {desc_label}")
+
+    size_coeffs = NBumiFitDispVsMeanGPU(fit, suppress_plot=True)
+    
+    tjs_gpu = cp.asarray(vals['tjs'].values, dtype=cp.float64)
+    tis_gpu = cp.asarray(vals['tis'].values, dtype=cp.float64) 
+    total = vals['total']
+
+    mean_expression_gpu = tjs_gpu / nc
+    log_mean_expression_gpu = cp.zeros_like(mean_expression_gpu)
+    valid_means = mean_expression_gpu > 0
+    log_mean_expression_gpu[valid_means] = cp.log(mean_expression_gpu[valid_means])
+    smoothed_size_gpu = cp.exp(size_coeffs[0] + size_coeffs[1] * log_mean_expression_gpu)
+
+    row_ps_gpu = cp.zeros(ng, dtype=cp.float64)
+    col_ps_gpu = cp.zeros(nc, dtype=cp.float64)
+
+    current_row = 0
+    while current_row < nc:
+        # [FIX] Keep overhead low (1.1) because we are using Fused Kernel
+        end_row = device.get_next_chunk(current_row, mode='dense', overhead_multiplier=1.1)
+        if end_row is None or end_row <= current_row: break
+        
+        chunk_size = end_row - current_row
+        
+        # [UI] Phase-aware progress bar
+        print(f"{phase_label}: Processing {end_row} of {nc} | Chunk: {chunk_size}", end='\r')
+
+        tis_chunk_gpu = tis_gpu[current_row:end_row]
+        
+        # [CRITICAL] FUSED KERNEL PRESERVED (Supercomputer Fix)
+        # Explicit float64 for the output buffer
+        p_is_chunk_gpu = cp.empty((chunk_size, ng), dtype=cp.float64)
+        
+        dropout_prob_kernel(
+            tjs_gpu,                 # Gene totals
+            tis_chunk_gpu[:, None],  # Cell totals
+            total,                   # Grand total
+            smoothed_size_gpu,       # Exp size
+            p_is_chunk_gpu           # Output
+        )
+
+        p_is_chunk_gpu = cp.nan_to_num(p_is_chunk_gpu, nan=0.0, posinf=1.0, neginf=0.0)
+        
+        row_ps_gpu += p_is_chunk_gpu.sum(axis=0)
+        col_ps_gpu[current_row:end_row] = p_is_chunk_gpu.sum(axis=1)
+        
+        del p_is_chunk_gpu, tis_chunk_gpu
+        cp.get_default_memory_pool().free_all_blocks()
+        current_row = end_row
+
+    # [UI] Clean completion - Force Newline
+    print("")
+    print(f"{phase_label}: COMPLETE")
+
+    row_ps_cpu = row_ps_gpu.get()
+    col_ps_cpu = col_ps_gpu.get()
+    
+    return {
+        'rowPs': pd.Series(row_ps_cpu, index=fit['vals']['tjs'].index),
+        'colPs': pd.Series(col_ps_cpu, index=fit['vals']['tis'].index)
+    }
+
+def NBumiCompareModelsGPU(
+    raw_filename: str,
+    stats: dict,
+    fit_adjust: dict,
+    mask_filename: str = None, 
+    mode: str = "auto",
+    manual_target: int = 3000,
+    suppress_plot=False,
+    plot_filename=None
+) -> dict:
+    """
+    Orchestrates the Comparison Pipeline with standardized UI.
+    """
+    print(f"FUNCTION: NBumiCompareModelsGPU()")
+    pipeline_start_time = time.time()
+
+    # STEP 1: Fit Basic Model
+    # [UI FIX] Removed early print, passed as desc_label
+    fit_basic = NBumiFitBasicModelGPU(
+        raw_filename, 
+        stats, 
+        mask_filename=mask_filename,
+        mode=mode, 
+        manual_target=manual_target,
+        phase_label="Phase [1/3]",
+        desc_label="Fitting Basic Model (Virtual)..."
+    )
+    
+    # STEP 2: Depth-Adjusted Dropout
+    # [UI FIX] Removed early print, passed as desc_label
+    check_adjust = NBumiCheckFitFSGPU(
+        raw_filename, 
+        fit_adjust, 
+        mode=mode, 
+        manual_target=manual_target, 
+        suppress_plot=True,
+        phase_label="Phase [2/3]",
+        desc_label="Calculating Depth-Adjusted Dropouts..."
+    )
+    
+    # STEP 3: Basic Dropout
+    # [UI FIX] Removed early print, passed as desc_label
+    stats_virtual = stats.copy()
+    mean_depth = stats['total'] / stats['nc']
+    stats_virtual['tis'] = pd.Series(
+        np.full(stats['nc'], mean_depth), 
+        index=stats['tis'].index
+    )
+    
+    fit_basic_for_eval = {
+        'sizes': fit_basic['sizes'],
+        'vals': stats_virtual,
+        'var_obs': fit_basic['var_obs']
+    }
+    
+    check_basic = NBumiCheckFitFSGPU(
+        raw_filename, 
+        fit_basic_for_eval, 
+        mode=mode, 
+        manual_target=manual_target, 
+        suppress_plot=True,
+        phase_label="Phase [3/3]",
+        desc_label="Calculating Basic Dropouts..."
+    )
+
+    # Calculation & Plotting
+    nc_data = stats['nc']
+    mean_expr = stats['tjs'] / nc_data
+    observed_dropout = stats['djs'] / nc_data
+    
+    adj_dropout_fit = check_adjust['rowPs'] / nc_data
+    bas_dropout_fit = check_basic['rowPs'] / nc_data
+    
+    err_adj = np.sum(np.abs(adj_dropout_fit - observed_dropout))
+    err_bas = np.sum(np.abs(bas_dropout_fit - observed_dropout))
+    
+    comparison_df = pd.DataFrame({
+        'mean_expr': mean_expr,
+        'observed': observed_dropout,
+        'adj_fit': adj_dropout_fit,
+        'bas_fit': bas_dropout_fit
+    })
+    
+    # Plotting Logic
+    plt.figure(figsize=(10, 6))
+    sorted_idx = np.argsort(mean_expr.values)
+    plot_idx = sorted_idx[::2] if len(mean_expr) > 20000 else sorted_idx
+
+    plt.scatter(mean_expr.iloc[plot_idx], observed_dropout.iloc[plot_idx], 
+                c='black', s=3, alpha=0.5, label='Observed')
+    
+    plt.scatter(mean_expr.iloc[plot_idx], bas_dropout_fit.iloc[plot_idx], 
+                c='purple', s=3, alpha=0.6, label=f'Basic Fit (Error: {err_bas:.2f})')
+    
+    plt.scatter(mean_expr.iloc[plot_idx], adj_dropout_fit.iloc[plot_idx], 
+                c='goldenrod', s=3, alpha=0.7, label=f'Depth-Adjusted Fit (Error: {err_adj:.2f})')
+    
+    plt.xscale('log')
+    plt.xlabel("Mean Expression")
+    plt.ylabel("Dropout Rate")
+    plt.title("M3Drop Model Comparison")
+    plt.legend()
+    plt.grid(True, linestyle='--', alpha=0.3)
+
+    if plot_filename:
+        plt.savefig(plot_filename, dpi=300, bbox_inches='tight')
+        print(f"Saving plot to: {plot_filename}")
+
+    if not suppress_plot:
+        plt.show()
+    
+    plt.close()
+
+    pipeline_end_time = time.time()
+    print(f"Total time: {pipeline_end_time - pipeline_start_time:.2f} seconds.\n")
+    
+    return {
+        "errors": {"Depth-Adjusted": err_adj, "Basic": err_bas},
+        "comparison_df": comparison_df
+    }
+
+def NBumiPlotDispVsMeanGPU(
+    fit: dict,
+    suppress_plot: bool = False,
+    plot_filename: str = None
+):
+    print("FUNCTION: NBumiPlotDispVsMean()")
+    start_time = time.time()
+        
+    mean_expression = fit['vals']['tjs'].values / fit['vals']['nc']
+    sizes = fit['sizes'].values
+    
+    coeffs = NBumiFitDispVsMeanGPU(fit, suppress_plot=True)
+    intercept, slope = coeffs[0], coeffs[1]
+
+    log_mean_expr_range = np.linspace(
+        np.log(mean_expression[mean_expression > 0].min()),
+        np.log(mean_expression.max()),
+        100
+    )
+    log_fitted_sizes = intercept + slope * log_mean_expr_range
+    fitted_sizes = np.exp(log_fitted_sizes)
+
+    plt.figure(figsize=(8, 6))
+    plt.scatter(mean_expression, sizes, label='Observed Dispersion', alpha=0.5, s=8)
+    plt.plot(np.exp(log_mean_expr_range), fitted_sizes, color='red', label='Regression Fit', linewidth=2)
+
+    plt.xscale('log')
+    plt.yscale('log')
+    plt.xlabel('Mean Expression')
+    plt.ylabel('Dispersion Parameter (Sizes)')
+    plt.title('Dispersion vs. Mean Expression')
+    plt.legend()
+    plt.grid(True, which="both", linestyle='--', alpha=0.6)
+
+    if plot_filename:
+        plt.savefig(plot_filename, dpi=300, bbox_inches='tight')
+        print(f"Saving plot to: {plot_filename}")
+            
+    if not suppress_plot:
+        plt.show()
+
+    plt.close()
+    
+    end_time = time.time()
+    print(f"Total time: {end_time - start_time:.2f} seconds.\n")

m3Drop/NormalizationCPU.py

@@ -0,0 +1,199 @@
+import pickle
+import time
+import sys
+import numpy as np
+import h5py
+import anndata
+import pandas as pd
+import os
+from scipy import sparse
+
+try:
+    from numba import jit, prange
+except ImportError:
+    print("CRITICAL ERROR: 'numba' not found. Please install it (pip install numba).")
+    sys.exit(1)
+
+# [FIX] Strict Relative Import
+from .ControlDeviceCPU import ControlDevice
+
+# ==========================================
+#        NUMBA KERNELS (CPU)
+# ==========================================
+
+@jit(nopython=True, parallel=True, fastmath=True)
+def pearson_residual_kernel_cpu(counts, tj, ti, theta, total, out_matrix):
+    """
+    Calculates Pearson residuals using Negative Binomial logic.
+    Parallelized across CPU cores.
+    """
+    rows = counts.shape[0]
+    cols = counts.shape[1]
+    
+    for r in prange(rows):
+        ti_val = ti[r]
+        for c in range(cols):
+            count_val = counts[r, c]
+            mu = (tj[c] * ti_val) / total
+            
+            # theta is vector of size cols (genes)
+            theta_val = theta[c]
+            
+            denom_sq = mu + ((mu * mu) / theta_val)
+            denom = np.sqrt(denom_sq)
+            
+            if denom < 1e-12:
+                out_matrix[r, c] = 0.0
+            else:
+                out_matrix[r, c] = (count_val - mu) / denom
+
+@jit(nopython=True, parallel=True, fastmath=True)
+def pearson_approx_kernel_cpu(counts, tj, ti, total, out_matrix):
+    """
+    Calculates Approximate Pearson residuals (Poisson limit).
+    """
+    rows = counts.shape[0]
+    cols = counts.shape[1]
+    
+    for r in prange(rows):
+        ti_val = ti[r]
+        for c in range(cols):
+            count_val = counts[r, c]
+            mu = (tj[c] * ti_val) / total
+            
+            denom = np.sqrt(mu)
+            
+            if denom < 1e-12:
+                out_matrix[r, c] = 0.0
+            else:
+                out_matrix[r, c] = (count_val - mu) / denom
+
+# ==========================================
+#        NORMALIZATION FUNCTION
+# ==========================================
+
+def NBumiPearsonResidualsCombinedCPU(
+    raw_filename: str, 
+    mask_filename: str, 
+    fit_filename: str, 
+    stats_filename: str,
+    output_filename_full: str,
+    output_filename_approx: str,
+    mode: str = "auto",
+    manual_target: int = 3000
+):
+    """
+    CPU-Optimized: Calculates Full and Approximate residuals in a SINGLE PASS.
+    Uses Numba for acceleration on L3-sized dense chunks.
+    """
+    start_time = time.perf_counter()
+    print(f"FUNCTION: NBumiPearsonResidualsCombinedCPU() | FILE: {raw_filename}")
+
+    # 1. Load Mask
+    with open(mask_filename, 'rb') as f: mask = pickle.load(f)
+    ng_filtered = int(np.sum(mask))
+
+    # 2. Init Device
+    with h5py.File(raw_filename, 'r') as f: indptr_cpu = f['X']['indptr'][:]; total_rows = len(indptr_cpu) - 1
+    device = ControlDevice(indptr=indptr_cpu, total_rows=total_rows, n_genes=ng_filtered, mode=mode, manual_target=manual_target)
+    nc = device.total_rows
+
+    print("Phase [1/2]: Initializing parameters...")
+    # Load parameters
+    with open(fit_filename, 'rb') as f: fit = pickle.load(f)
+    with open(stats_filename, 'rb') as f: stats = pickle.load(f)
+    
+    # Common params (Numpy Arrays)
+    total = fit['vals']['total']
+    tjs = fit['vals']['tjs'].values.astype(np.float64)
+    tis = fit['vals']['tis'].values.astype(np.float64)
+    
+    # Specific params
+    sizes = fit['sizes'].values.astype(np.float64) # For Full
+
+    # Setup Output Files
+    adata_in = anndata.read_h5ad(raw_filename, backed='r')
+    filtered_var = adata_in.var[mask]
+    
+    # Create skeletons
+    adata_out_full = anndata.AnnData(obs=adata_in.obs, var=filtered_var)
+    adata_out_full.write_h5ad(output_filename_full, compression=None)
+    
+    adata_out_approx = anndata.AnnData(obs=adata_in.obs, var=filtered_var)
+    adata_out_approx.write_h5ad(output_filename_approx, compression=None)
+    
+    # Calculate appropriate H5 storage chunks
+    storage_chunk_rows = int(1_000_000_000 / (ng_filtered * 8)) 
+    if storage_chunk_rows < 1: storage_chunk_rows = 1
+    
+    # Open both files for writing simultaneously
+    with h5py.File(output_filename_full, 'a') as f_full, h5py.File(output_filename_approx, 'a') as f_approx:
+        if 'X' in f_full: del f_full['X']
+        if 'X' in f_approx: del f_approx['X']
+        
+        # Float64 output
+        out_x_full = f_full.create_dataset(
+            'X', shape=(nc, ng_filtered), chunks=(storage_chunk_rows, ng_filtered), dtype='float64'
+        )
+        out_x_approx = f_approx.create_dataset(
+            'X', shape=(nc, ng_filtered), chunks=(storage_chunk_rows, ng_filtered), dtype='float64'
+        )
+
+        with h5py.File(raw_filename, 'r') as f_in:
+            h5_indptr = f_in['X']['indptr']
+            h5_data = f_in['X']['data']
+            h5_indices = f_in['X']['indices']
+            
+            current_row = 0
+            while current_row < nc:
+                # Dense mode is faster for Numba
+                end_row = device.get_next_chunk(current_row, mode='dense', overhead_multiplier=3.0) 
+                if end_row is None or end_row <= current_row: break
+
+                chunk_size = end_row - current_row
+                print(f"Phase [2/2]: Processing rows {end_row} of {nc} | Chunk: {chunk_size}", end='\r')
+
+                start_idx, end_idx = h5_indptr[current_row], h5_indptr[end_row]
+                
+                # Load & Filter
+                data = np.array(h5_data[start_idx:end_idx], dtype=np.float64)
+                indices = np.array(h5_indices[start_idx:end_idx])
+                indptr = np.array(h5_indptr[current_row:end_row+1] - h5_indptr[current_row])
+                
+                chunk_csr = sparse.csr_matrix((data, indices, indptr), shape=(chunk_size, len(mask)))
+                chunk_csr = chunk_csr[:, mask]
+                chunk_csr.data = np.ceil(chunk_csr.data)
+
+                # Convert to Dense for Numba (faster than sparse iteration for dense ops)
+                counts_dense = chunk_csr.toarray()
+                
+                # --- CALC 1: APPROX ---
+                approx_out = np.empty_like(counts_dense)
+                pearson_approx_kernel_cpu(
+                    counts_dense,
+                    tjs,
+                    tis[current_row:end_row], 
+                    total,
+                    approx_out 
+                )
+                out_x_approx[current_row:end_row, :] = approx_out
+                del approx_out
+
+                # --- CALC 2: FULL (In-place on counts_dense) ---
+                # We can reuse the counts_dense buffer for output to save RAM
+                pearson_residual_kernel_cpu(
+                    counts_dense,
+                    tjs,
+                    tis[current_row:end_row], 
+                    sizes,
+                    total,
+                    counts_dense # Overwrite input
+                )
+                out_x_full[current_row:end_row, :] = counts_dense
+                
+                current_row = end_row
+        
+        print(f"\nPhase [2/2]: COMPLETE{' '*50}")
+    
+    if hasattr(adata_in, "file") and adata_in.file is not None: adata_in.file.close()
+    print(f"Total time: {time.perf_counter() - start_time:.2f} seconds.\n")

m3Drop/{normalizationGPU.py → NormalizationGPU.py}

@@ -1,8 +1,3 @@
-try:
-    from .coreGPU import get_optimal_chunk_size
-except ImportError:
-    from coreGPU import get_optimal_chunk_size
-
 import pickle
 import time
 import cupy
@@ -13,6 +8,8 @@ import pandas as pd
 from cupy.sparse import csr_matrix as cp_csr_matrix
 import os
 
+from .ControlDeviceGPU import ControlDevice
+
 def NBumiPearsonResidualsGPU(
     cleaned_filename: str,
     fit_filename: str,
@@ -211,3 +208,4 @@ def NBumiPearsonResidualsApproxGPU(
 
     end_time = time.perf_counter()
     print(f"Total time: {end_time - start_time:.2f} seconds.\n")
+