wgts-report 0.1.8 → 0.1.9

package/dist/assets/wgts-report.js

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t.flags&256?(Kl(t),t.flags&=-257,Xo(e,t,S)):t.memoizedState!==null?(Zl(),t.child=e.child,t.flags|=128,null):(Zl(),c=o.fallback,g=t.mode,o=Io({mode:"visible",children:o.children},g),c=Ha(c,g,S,null),c.flags|=2,o.return=t,c.return=t,o.sibling=c,t.child=o,qa(t,e.child,null,S),o=t.child,o.memoizedState=Cf(S),o.childLanes=Nf(e,a,S),t.memoizedState=jf,rr(null,o));if(Kl(t),Cd(c)){if(a=c.nextSibling&&c.nextSibling.dataset,a)var _=a.dgst;return a=_,a!==""&&(o=Error(r(419)),o.stack="",o.digest=a,Ki({value:o,source:null,stack:null})),Xo(e,t,S)}if(St||Va(e,t,S,!1),a=(S&e.childLanes)!==0,St||a){if(Xl.current!==null)return Xo(e,t,S);if(a=tt,a!==null&&(o=Em(a,S),o!==0&&o!==g.retryLane))throw g.retryLane=o,Da(e,o),on(a,e,o),bf;return jd(c)||du(),Xo(e,t,S)}return jd(c)?(t.flags|=192,t.child=e.child,null):(e=g.treeContext,lt=Tn(c.nextSibling),Mt=t,Re=!0,Bl=null,_n=!1,e!==null&&Eg(t,e),t=Ef(t,o.children),t.flags|=134221824,t)}function Qp(e,t,l){e.lanes|=t;var a=e.alternate;a!==null&&(a.lanes|=t),Eo(e.return,t,l)}function Yp(e){for(var t=null;e!==null;){var l=e.alternate;l!==null&&Ho(l)===null&&(t=e),e=e.sibling}return t}function Ko(e,t,l,a,o,c){var g=e.memoizedState;g===null?e.memoizedState={isBackwards:t,rendering:null,renderingStartTime:0,last:a,tail:l,tailMode:o,treeForkCount:c}:(g.isBackwards=t,g.rendering=null,g.renderingStartTime=0,g.last=a,g.tail=l,g.tailMode=o,g.treeForkCount=c)}function Mf(e){var t=e.child;for(e.child=null;t!==null;){var l=t.sibling;t.sibling=e.child,e.child=t,t=l}}function _f(e,t,l){var a=t.pendingProps,o=a.revealOrder,c=a.tail;a=a.children;var g=Dt.current;if(t.flags&128)return lr(t,g),null;var S=(g&2)!==0;if(S?(g=g&1|2,t.flags|=128):g&=1,lr(t,g),o==="backwards"&&e!==null?(Mf(e),Ct(e,t,a,l),Mf(e)):Ct(e,t,a,l),a=Re?Xi:0,!S&&e!==null&&(e.flags&128)!==0)e:for(e=t.child;e!==null;){if(e.tag===13)e.memoizedState!==null&&Qp(e,l,t);else if(e.tag===19)Qp(e,l,t);else if(e.child!==null){e.child.return=e,e=e.child;continue}if(e===t)break e;for(;e.sibling===null;){if(e.return===null||e.return===t)break e;e=e.return}e.sibling.return=e.return,e=e.sibling}switch(o){case"backwards":l=Yp(t.child),l===null?(o=t.child,t.child=null):(o=l.sibling,l.sibling=null,Mf(t)),Ko(t,!0,o,null,c,a);break;case"unstable_legacy-backwards":for(l=null,o=t.child,t.child=null;o!==null;){if(e=o.alternate,e!==null&&Ho(e)===null){t.child=o;break}e=o.sibling,o.sibling=l,l=o,o=e}Ko(t,!0,l,null,c,a);break;case"together":Ko(t,!1,null,null,void 0,a);break;case"independent":t.memoizedState=null;break;default:l=Yp(t.child),l===null?(o=t.child,t.child=null):(o=l.sibling,l.sibling=null),Ko(t,!1,o,l,c,a)}return t.child}function Ip(e,t,l){var a=t.pendingProps;return Gl(t,t.type,a.value),Ct(e,t,a.children,l),t.child}function Cl(e,t,l){if(e!==null&&(t.dependencies=e.dependencies),ea|=t.lanes,(l&t.childLanes)===0)if(e!==null){if(Va(e,t,l,!1),(l&t.childLanes)===0)return null}else return null;if(e!==null&&t.child!==e.child)throw Error(r(153));if(t.child!==null){for(e=t.child,l=yl(e,e.pendingProps),t.child=l,l.return=t;e.sibling!==null;)e=e.sibling,l=l.sibling=yl(e,e.pendingProps),l.return=t;l.sibling=null}return t.child}function Rf(e,t){return(e.lanes&t)!==0?!0:(e=e.dependencies,!!(e!==null&&Mo(e)))}function YS(e,t,l){switch(t.tag){case 3:dl(t,t.stateNode.containerInfo),Gl(t,yt,e.memoizedState.cache),La();break;case 27:case 5:fn(t);break;case 4:dl(t,t.stateNode.containerInfo);break;case 10:Gl(t,t.type,t.memoizedProps.value);break;case 31:if(t.memoizedState!==null)return t.flags|=128,Wc(t),null;break;case 13:var a=t.memoizedState;if(a!==null){if(a.dehydrated!==null)return Kl(t),t.flags|=128,null;a=Va(e,t,l,!1);var o=t.child.childLanes;return a||(l&o)!==0?qp(e,t,l):(Kl(t),e=Cl(e,t,l),e!==null?e.sibling:null)}Kl(t);break;case 19:if(t.flags&128)return _f(e,t,l);if(o=(e.flags&128)!==0,a=(l&t.childLanes)!==0,a||(Va(e,t,l,!1),a=(l&t.childLanes)!==0),o){if(a)return _f(e,t,l);t.flags|=128}if(o=t.memoizedState,o!==null&&(o.rendering=null,o.tail=null,o.lastEffect=null),lr(t,Dt.current),a)break;return null;case 22:return t.lanes=0,Vp(e,t,l,t.pendingProps);case 24:Gl(t,yt,e.memoizedState.cache)}return Cl(e,t,l)}function Xp(e,t,l){if(e!==null)if(e.memoizedProps!==t.pendingProps)St=!0;else{if(!Rf(e,l)&&(t.flags&128)===0)return St=!1,YS(e,t,l);St=(e.flags&131072)!==0}else St=!1,Re&&(t.flags&1048576)!==0&&Ng(t,Xi,t.index);switch(t.lanes=0,t.tag){case 16:e:{var a=t.pendingProps;if(e=ka(t.elementType),t.type=e,typeof e=="function")Hc(e)?(a=Ya(e,a),t.tag=1,t=kp(null,t,e,a,l)):(t.tag=0,t=wf(null,t,e,a,l));else{if(e!=null){var o=e.$$typeof;if(o===X){t.tag=11,t=Hp(null,t,e,a,l);break e}else if(o===ve){t.tag=14,t=Lp(null,t,e,a,l);break e}else if(o===W){t.tag=10,t.type=e,t=Ip(null,t,l);break e}}throw t=Se(e)||e,Error(r(306,t,""))}}return t;case 0:return wf(e,t,t.type,t.pendingProps,l);case 1:return a=t.type,o=Ya(a,t.pendingProps),kp(e,t,a,o,l);case 3:e:{if(dl(t,t.stateNode.containerInfo),e===null)throw Error(r(387));a=t.pendingProps;var c=t.memoizedState;o=c.element,Xc(e,t),nr(t,a,null,l);var g=t.memoizedState;if(a=g.cache,Gl(t,yt,a),a!==c.cache&&kc(t,[yt],l,!0),tr(),a=g.element,c.isDehydrated)if(c={element:a,isDehydrated:!1,cache:g.cache},t.updateQueue.baseState=c,t.memoizedState=c,t.flags&256){t=Gp(e,t,a,l);break e}else if(a!==o){o=Nn(Error(r(424)),t),Ki(o),t=Gp(e,t,a,l);break e}else{switch(e=t.stateNode.containerInfo,e.nodeType){case 9:e=e.body;break;default:e=e.nodeName==="HTML"?e.ownerDocument.body:e}for(lt=Tn(e.firstChild),Mt=t,Re=!0,Bl=null,_n=!0,l=Vg(t,null,a,l),t.child=l;l;)l.flags=l.flags&-3|134221824,l=l.sibling}else{if(La(),a===o){t=Cl(e,t,l);break e}Ct(e,t,a,l)}t=t.child}return t;case 26:return Vs(e,t),e===null?(l=xv(t.type,null,t.pendingProps,null))?t.memoizedState=l:Re||(t.stateNode=J0(t.type,t.pendingProps,tn.current,t)):t.memoizedState=xv(t.type,e.memoizedProps,t.pendingProps,e.memoizedState),null;case 27:return fn(t),e===null&&Re&&(a=t.stateNode=gv(t.type,t.pendingProps,tn.current),Mt=t,_n=!0,o=lt,aa(t.type)?(Nd=o,lt=Tn(a.firstChild)):lt=o),Ct(e,t,t.pendingProps.children,l),Vs(e,t),e===null&&(t.flags|=4194304),t.child;case 5:return e===null&&Re&&((o=a=lt)&&(a=Fb(a,t.type,t.pendingProps,_n),a!==null?(t.stateNode=a,Mt=t,lt=Tn(a.firstChild),_n=!1,o=!0):o=!1),o||kl(t)),fn(t),o=t.type,c=t.pendingProps,g=e!==null?e.memoizedProps:null,a=c.children,pd(o,c)?a=null:g!==null&&pd(o,g)&&(t.flags|=32),t.memoizedState!==null&&(o=nf(e,t,HS,null,null,l),ni._currentValue=o),Vs(e,t),Ct(e,t,a,l),t.child;case 6:return e===null&&Re&&((e=l=lt)&&(l=Bb(l,t.pendingProps,_n),l!==null?(t.stateNode=l,Mt=t,lt=null,e=!0):e=!1),e||kl(t)),null;case 13:return qp(e,t,l);case 4:return dl(t,t.stateNode.containerInfo),a=t.pendingProps,e===null?t.child=qa(t,null,a,l):Ct(e,t,a,l),t.child;case 11:return Hp(e,t,t.type,t.pendingProps,l);case 7:return a=t.pendingProps,Vs(e,t),Ct(e,t,a,l),t.child;case 8:return Ct(e,t,t.pendingProps.children,l),t.child;case 12:return Ct(e,t,t.pendingProps.children,l),t.child;case 10:return Ip(e,t,l);case 9:return o=t.type._context,a=t.pendingProps.children,$a(t),o=Ot(o),a=a(o),t.flags|=1,Ct(e,t,a,l),t.child;case 14:return Lp(e,t,t.type,t.pendingProps,l);case 15:return Up(e,t,t.type,t.pendingProps,l);case 19:return _f(e,t,l);case 31:return qS(e,t,l);case 22:return Vp(e,t,l,t.pendingProps);case 24:return $a(t),a=Ot(yt),e===null?(o=Qc(),o===null&&(o=tt,c=Gc(),o.pooledCache=c,c.refCount++,c!==null&&(o.pooledCacheLanes|=l),o=c),t.memoizedState={parent:a,cache:o},Ic(t),Gl(t,yt,o)):((e.lanes&l)!==0&&(Xc(e,t),nr(t,null,null,l),tr()),o=e.memoizedState,c=t.memoizedState,o.parent!==a?(o={parent:a,cache:a},t.memoizedState=o,t.lanes===0&&(t.memoizedState=t.updateQueue.baseState=o),Gl(t,yt,a)):(a=c.cache,Gl(t,yt,a),a!==o.cache&&kc(t,[yt],l,!0))),Ct(e,t,t.pendingProps.children,l),t.child;case 30:return t.stateNode===null&&(t.stateNode={autoName:null,paired:null,clones:null,ref:null}),a=t.pendingProps,a.name!=null&&a.name!=="auto"?t.flags|=e===null?18882560:18874368:Re&&Co(t),e!==null&&e.memoizedProps.name!==a.name?t.flags|=4194816:Vs(e,t),Ct(e,t,a.children,l),t.child;case 29:throw t.pendingProps}throw Error(r(156,t.tag))}function Nl(e){e.flags|=4}function Tf(e,t,l,a,o){var c;if((c=(e.mode&32)!==0)&&(c=l===null?jv(t,a):jv(t,a)&&(a.src!==l.src||a.srcSet!==l.srcSet)),c){if(e.flags|=16777216,(o&335544128)===o)if(e.stateNode.complete)e.flags|=8192;else if(R0())e.flags|=8192;else throw Ga=Ao,Yc}else e.flags&=-16777217}function Kp(e,t){if(t.type!=="stylesheet"||(t.state.loading&4)!==0)e.flags&=-16777217;else if(e.flags|=16777216,!Cv(t))if(R0())e.flags|=8192;else throw Ga=Ao,Yc}function Zo(e,t){t!==null&&(e.flags|=4),e.flags&16384&&(t=e.tag!==22?jm():536870912,e.lanes|=t,Gs|=t)}function or(e,t){if(!Re)switch(e.tailMode){case"visible":break;case"collapsed":for(var l=e.tail,a=null;l!==null;)l.alternate!==null&&(a=l),l=l.sibling;a===null?t||e.tail===null?e.tail=null:e.tail.sibling=null:a.sibling=null;break;default:for(t=e.tail,l=null;t!==null;)t.alternate!==null&&(l=t),t=t.sibling;l===null?e.tail=null:l.sibling=null}}function at(e){var t=e.alternate!==null&&e.alternate.child===e.child,l=0,a=0;if(t)for(var o=e.child;o!==null;)l|=o.lanes|o.childLanes,a|=o.subtreeFlags&1206910976,a|=o.flags&1206910976,o.return=e,o=o.sibling;else for(o=e.child;o!==null;)l|=o.lanes|o.childLanes,a|=o.subtreeFlags,a|=o.flags,o.return=e,o=o.sibling;return e.subtreeFlags|=a,e.childLanes=l,t}function IS(e,t,l){var a=t.pendingProps;switch(Vc(t),t.tag){case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return at(t),null;case 1:return at(t),null;case 3:return l=t.stateNode,a=null,e!==null&&(a=e.memoizedState.cache),t.memoizedState.cache!==a&&(t.flags|=2048),bl(yt),ht(),l.pendingContext&&(l.context=l.pendingContext,l.pendingContext=null),(e===null||e.child===null)&&(As(t)?Nl(t):e===null||e.memoizedState.isDehydrated&&(t.flags&256)===0||(t.flags|=1024,Fc())),at(t),null;case 26:var o=t.type,c=t.memoizedState;return e===null?(Nl(t),c!==null?(at(t),Kp(t,c)):(at(t),Tf(t,o,null,a,l))):c?c!==e.memoizedState?(Nl(t),at(t),Kp(t,c)):(at(t),t.flags&=-16777217):(e=e.memoizedProps,e!==a&&Nl(t),at(t),Tf(t,o,e,a,l)),null;case 27:if(Yt(t),l=tn.current,o=t.type,e!==null&&t.stateNode!=null)e.memoizedProps!==a&&Nl(t);else{if(!a){if(t.stateNode===null)throw Error(r(166));return at(t),t.subtreeFlags&=-33554433,null}e=Qt.current,As(t)?Mg(t):(e=gv(o,a,l),t.stateNode=e,Nl(t))}return at(t),t.subtreeFlags&=-33554433,null;case 5:if(Yt(t),o=t.type,e!==null&&t.stateNode!=null)e.memoizedProps!==a&&Nl(t);else{if(!a){if(t.stateNode===null)throw Error(r(166));return at(t),t.subtreeFlags&=-33554433,null}if(c=Qt.current,As(t))Mg(t);else{var g=xr(tn.current);switch(c){case 1:c=g.createElementNS("http://www.w3.org/2000/svg",o);break;case 2:c=g.createElementNS("http://www.w3.org/1998/Math/MathML",o);break;default:switch(o){case"svg":c=g.createElementNS("http://www.w3.org/2000/svg",o);break;case"math":c=g.createElementNS("http://www.w3.org/1998/Math/MathML",o);break;case"script":c=g.createElement("div"),c.innerHTML="<script><\/script>",c=c.removeChild(c.firstChild);break;case"select":c=typeof a.is=="string"?g.createElement("select",{is:a.is}):g.createElement("select"),a.multiple?c.multiple=!0:a.size&&(c.size=a.size);break;default:c=typeof a.is=="string"?g.createElement(o,{is:a.is}):g.createElement(o)}}c[At]=t,c[nn]=a;e:for(g=t.child;g!==null;){if(g.tag===5||g.tag===6)c.appendChild(g.stateNode);else if(g.tag!==4&&g.tag!==27&&g.child!==null){g.child.return=g,g=g.child;continue}if(g===t)break e;for(;g.sibling===null;){if(g.return===null||g.return===t)break e;g=g.return}g.sibling.return=g.return,g=g.sibling}t.stateNode=c;e:switch(Lt(c,o,a),o){case"button":case"input":case"select":case"textarea":a=!!a.autoFocus;break e;case"img":a=!0;break e;default:a=!1}a&&Nl(t)}}return at(t),t.subtreeFlags&=-33554433,Tf(t,t.type,e===null?null:e.memoizedProps,t.pendingProps,l),null;case 6:if(e&&t.stateNode!=null)e.memoizedProps!==a&&Nl(t);else{if(typeof a!="string"&&t.stateNode===null)throw Error(r(166));if(e=tn.current,As(t)){if(e=t.stateNode,l=t.memoizedProps,a=null,o=Mt,o!==null)switch(o.tag){case 27:case 5:a=o.memoizedProps}e[At]=t,e=!!(e.nodeValue===l||a!==null&&a.suppressHydrationWarning===!0||X0(e.nodeValue,l)),e||kl(t,!0)}else e=xr(e).createTextNode(a),e[At]=t,t.stateNode=e}return at(t),null;case 31:if(l=t.memoizedState,e===null||e.memoizedState!==null){if(a=As(t),l!==null){if(e===null){if(!a)throw Error(r(318));if(e=t.memoizedState,e=e!==null?e.dehydrated:null,!e)throw Error(r(557));e[At]=t}else 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Proxy(s,{get:(r,u)=>(this.trackProp(u),i==null||i(u),Reflect.get(r,u))})}trackProp(s){L(this,wi).add(s)}getCurrentQuery(){return L(this,He)}refetch({...s}={}){return this.fetch({...s})}fetchOptimistic(s){const i=L(this,Jt).defaultQueryOptions(s),r=L(this,Jt).getQueryCache().build(L(this,Jt),i);let u=()=>{},d;const h=new Promise(m=>{d=m,u=L(this,Jt).getQueryCache().subscribe(p=>{p.type==="updated"&&p.query.queryHash===r.queryHash&&r.state.data!==void 0&&(u(),m(this.createResult(r,i)))})});return Promise.race([r.fetch(i).then(()=>{const m=this.createResult(r,i);return d==null||d(m),m}).finally(()=>{u()}),h])}fetch(s){return De(this,Ie,Ur).call(this,{...s,cancelRefetch:s.cancelRefetch??!0}).then(()=>(this.updateResult(),L(this,Wt)))}createResult(s,i){var D;const r=L(this,He),u=this.options,d=L(this,Wt),h=L(this,os),m=L(this,xi),p=s!==r?s.state:L(this,Kr),{state:y}=s;let x={...y},v=!1,b;if(i._optimisticResults){const O=this.hasListeners(),I=!O&&ay(s,i),ee=O&&sy(s,r,i,u);(I||ee)&&(x={...x,...vx(y.data,s.options)}),i._optimisticResults==="isRestoring"&&(x.fetchStatus="idle")}let{error:w,errorUpdatedAt:j,status:N}=x;b=x.data;let M=!1;if(i.placeholderData!==void 0&&b===void 0&&N==="pending"){let O;d!=null&&d.isPlaceholderData&&i.placeholderData===(m==null?void 0:m.placeholderData)?(O=d.data,M=!0):O=typeof i.placeholderData=="function"?i.placeholderData((D=L(this,bi))==null?void 0:D.state.data,L(this,bi)):i.placeholderData,O!==void 0&&(N="success",b=Ch(d==null?void 0:d.data,O,i),v=!0)}if(i.select&&b!==void 0&&!M)if(d&&b===(h==null?void 0:h.data)&&i.select===L(this,Zr))b=L(this,Si);else try{fe(this,Zr,i.select),b=i.select(b),b=Ch(d==null?void 0:d.data,b,i),fe(this,Si,b),fe(this,Ol,null)}catch(O){fe(this,Ol,O)}else b===void 0&&fe(this,Ol,null);L(this,Ol)&&(w=L(this,Ol),b=L(this,Si),j=Date.now(),N="error",v=!1);const R=x.fetchStatus==="fetching",E=N==="pending",U=N==="error",T=E&&R,H=b!==void 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this.options.throwOnError&&m.add("error"),Object.keys(L(this,Wt)).some(p=>{const y=p;return L(this,Wt)[y]!==s[y]&&m.has(y)})})();Vt.batch(()=>{u&&this.listeners.forEach(d=>{d(L(this,Wt))}),L(this,Jt).getQueryCache().notify({query:L(this,He),type:"observerResultsUpdated"})})}onQueryUpdate(){this.updateResult(),this.hasListeners()&&De(this,Ie,Ah).call(this)}},Jt=new WeakMap,He=new WeakMap,Kr=new WeakMap,Wt=new WeakMap,os=new WeakMap,xi=new WeakMap,Ol=new WeakMap,Zr=new WeakMap,Si=new WeakMap,bi=new WeakMap,us=new WeakMap,cs=new WeakMap,pa=new WeakMap,wi=new WeakMap,Ie=new WeakSet,Ur=function(s){De(this,Ie,Dh).call(this);let i=L(this,He).fetch(this.options,s);return s!=null&&s.throwOnError||(i=i.catch(cn)),i},Mh=function(s){return!im()&&ut(this.options.enabled,L(this,He))!==!1&&rx(s)},_h=function(){De(this,Ie,Oh).call(this);const s=ut(this.options.staleTime,L(this,He));if(L(this,Wt).isStale||!De(this,Ie,Mh).call(this,s))return;const i=ox(L(this,Wt).dataUpdatedAt,s)+1;fe(this,us,ns.setTimeout(()=>{L(this,Wt).isStale||this.updateResult()},i))},Rh=function(){return ut(this.options.refetchInterval,L(this,He))??!1},Th=function(s){De(this,Ie,zh).call(this),fe(this,pa,s),!(L(this,pa)===0||!De(this,Ie,Mh).call(this,L(this,pa)))&&fe(this,cs,ns.setInterval(()=>{(this.options.refetchIntervalInBackground||rm.isFocused())&&De(this,Ie,Ur).call(this)},L(this,pa)))},Ah=function(){De(this,Ie,_h).call(this),De(this,Ie,Th).call(this,De(this,Ie,Rh).call(this))},Oh=function(){L(this,us)!==void 0&&(ns.clearTimeout(L(this,us)),fe(this,us,void 0))},zh=function(){L(this,cs)!==void 0&&(ns.clearInterval(L(this,cs)),fe(this,cs,void 0))},Dh=function(){const s=L(this,Jt).getQueryCache().build(L(this,Jt),this.options);if(s===L(this,He))return;const i=L(this,He);fe(this,He,s),fe(this,Kr,s.state),this.hasListeners()&&(i==null||i.removeObserver(this),s.addObserver(this))},Wy);function X2(n,s){return ut(s.enabled,n)!==!1&&n.state.data===void 0&&!(n.state.status==="error"&&ut(s.retryOnMount,n)===!1)}function ay(n,s){return X2(n,s)||n.state.data!==void 0&&Hh(n,s,s.refetchOnMount)}function Hh(n,s,i){if(ut(s.enabled,n)!==!1&&ut(s.staleTime,n)!=="static"){const r=ut(i,n);return r==="always"||r!==!1&&om(n,s)}return!1}function sy(n,s,i,r){return(n!==s||ut(r.enabled,n)===!1)&&(!i.suspense||n.state.status!=="error")&&om(n,i)}function om(n,s){return ut(s.enabled,n)!==!1&&n.isStaleByTime(ut(s.staleTime,n))}var K2=class extends yx{constructor(n,s){super(n,s)}bindMethods(){super.bindMethods(),this.fetchNextPage=this.fetchNextPage.bind(this),this.fetchPreviousPage=this.fetchPreviousPage.bind(this)}setOptions(n){n._type="infinite",super.setOptions(n)}getOptimisticResult(n){return n._type="infinite",super.getOptimisticResult(n)}fetchNextPage(n){return this.fetch({...n,meta:{fetchMore:{direction:"forward"}}})}fetchPreviousPage(n){return this.fetch({...n,meta:{fetchMore:{direction:"backward"}}})}createResult(n,s){var w,j;const{state:i}=n,r=super.createResult(n,s),{isFetching:u,isRefetching:d,isError:h,isRefetchError:m}=r,p=(j=(w=i.fetchMeta)==null?void 0:w.fetchMore)==null?void 0:j.direction,y=h&&p==="forward",x=u&&p==="forward",v=h&&p==="backward",b=u&&p==="backward";return{...r,fetchNextPage:this.fetchNextPage,fetchPreviousPage:this.fetchPreviousPage,hasNextPage:Q2(s,i.data),hasPreviousPage:Y2(s,i.data),isFetchNextPageError:y,isFetchingNextPage:x,isFetchPreviousPageError:v,isFetchingPreviousPage:b,isRefetchError:m&&!y&&!v,isRefetching:d&&!x&&!b}}},Pr,rl,qt,fs,ol,ca,ex,Z2=(ex=class extends gx{constructor(s){super();ye(this,ol);ye(this,Pr);ye(this,rl);ye(this,qt);ye(this,fs);fe(this,Pr,s.client),this.mutationId=s.mutationId,fe(this,qt,s.mutationCache),fe(this,rl,[]),this.state=s.state||P2(),this.setOptions(s.options),this.scheduleGc()}setOptions(s){this.options=s,this.updateGcTime(this.options.gcTime)}get meta(){return this.options.meta}addObserver(s){L(this,rl).includes(s)||(L(this,rl).push(s),this.clearGcTimeout(),L(this,qt).notify({type:"observerAdded",mutation:this,observer:s}))}removeObserver(s){fe(this,rl,L(this,rl).filter(i=>i!==s)),this.scheduleGc(),L(this,qt).notify({type:"observerRemoved",mutation:this,observer:s})}optionalRemove(){L(this,rl).length||(this.state.status==="pending"?this.scheduleGc():L(this,qt).remove(this))}continue(){var s;return((s=L(this,fs))==null?void 0:s.continue())??(this.state.status==="pending"?this.execute(this.state.variables):Promise.resolve())}async execute(s){var m,p,y,x,v,b,w,j,N,M,R,E,U,T,H,D,O,I;const i=()=>{De(this,ol,ca).call(this,{type:"continue"})},r={client:L(this,Pr),meta:this.options.meta,mutationKey:this.options.mutationKey},u=fe(this,fs,mx({fn:()=>this.options.mutationFn?this.options.mutationFn(s,r):Promise.reject(new Error("No mutationFn 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Wr{constructor(s={}){super();ye(this,va);ye(this,kn);ye(this,Jr);this.config=s,fe(this,va,new Set),fe(this,kn,new Map),fe(this,Jr,0)}build(s,i,r){const u=new Z2({client:s,mutationCache:this,mutationId:++Ru(this,Jr)._,options:s.defaultMutationOptions(i),state:r});return this.add(u),u}add(s){L(this,va).add(s);const i=Tu(s);if(typeof i=="string"){const r=L(this,kn).get(i);r?r.push(s):L(this,kn).set(i,[s])}this.notify({type:"added",mutation:s})}remove(s){if(L(this,va).delete(s)){const i=Tu(s);if(typeof i=="string"){const r=L(this,kn).get(i);if(r)if(r.length>1){const u=r.indexOf(s);u!==-1&&r.splice(u,1)}else r[0]===s&&L(this,kn).delete(i)}}this.notify({type:"removed",mutation:s})}canRun(s){var r;const i=Tu(s);if(typeof i=="string"){const u=(r=L(this,kn).get(i))==null?void 0:r.find(d=>d.state.status==="pending");return!u||u===s}else return!0}runNext(s){var r,u;const i=Tu(s);return typeof i=="string"?((u=(r=L(this,kn).get(i))==null?void 0:r.find(d=>d!==s&&d.state.isPaused))==null?void 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WeakMap,nx),dt,ya,xa,ji,Ci,Sa,Ni,Ei,lx,ew=(lx=class{constructor(n={}){ye(this,dt);ye(this,ya);ye(this,xa);ye(this,ji);ye(this,Ci);ye(this,Sa);ye(this,Ni);ye(this,Ei);fe(this,dt,n.queryCache||new W2),fe(this,ya,n.mutationCache||new J2),fe(this,xa,n.defaultOptions||{}),fe(this,ji,new Map),fe(this,Ci,new Map),fe(this,Sa,0)}mount(){Ru(this,Sa)._++,L(this,Sa)===1&&(fe(this,Ni,rm.subscribe(async n=>{n&&(await this.resumePausedMutations(),L(this,dt).onFocus())})),fe(this,Ei,$u.subscribe(async n=>{n&&(await this.resumePausedMutations(),L(this,dt).onOnline())})))}unmount(){var n,s;Ru(this,Sa)._--,L(this,Sa)===0&&((n=L(this,Ni))==null||n.call(this),fe(this,Ni,void 0),(s=L(this,Ei))==null||s.call(this),fe(this,Ei,void 0))}isFetching(n){return L(this,dt).findAll({...n,fetchStatus:"fetching"}).length}isMutating(n){return L(this,ya).findAll({...n,status:"pending"}).length}getQueryData(n){var i;const s=this.defaultQueryOptions({queryKey:n});return(i=L(this,dt).get(s.queryHash))==null?void 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3:e:{if($l(t,t.stateNode.containerInfo),e===null)throw Error(o(387));s=t.pendingProps;var f=t.memoizedState;r=f.element,af(e,t),fo(t,s,null,l);var p=t.memoizedState;if(s=p.cache,Kl(t,vt,s),s!==f.cache&&Jc(t,[vt],l,!0),co(),s=p.element,f.isDehydrated)if(f={element:s,isDehydrated:!1,cache:p.cache},t.updateQueue.baseState=f,t.memoizedState=f,t.flags&256){t=t0(e,t,s,l);break e}else if(s!==r){r=_n(Error(o(424)),t),ao(r),t=t0(e,t,s,l);break e}else{switch(e=t.stateNode.containerInfo,e.nodeType){case 9:e=e.body;break;default:e=e.nodeName==="HTML"?e.ownerDocument.body:e}for(tt=zn(e.firstChild),Tt=t,Te=!0,Il=null,An=!0,l=Pg(t,null,s,l),t.child=l;l;)l.flags=l.flags&-3|134221824,l=l.sibling}else{if(Ba(),s===r){t=_l(e,t,l);break e}Nt(e,t,s,l)}t=t.child}return t;case 26:return Qs(e,t),e===null?(l=Av(t.type,null,t.pendingProps,null))?t.memoizedState=l:Te||(t.stateNode=cv(t.type,t.pendingProps,Pt.current,t)):t.memoizedState=Av(t.type,e.memoizedProps,t.pendingProps,e.memoizedState),null;case 27:return 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Nt(e,t,t.pendingProps.children,l),t.child;case 12:return Nt(e,t,t.pendingProps.children,l),t.child;case 10:return s0(e,t,l);case 9:return r=t.type._context,s=t.pendingProps.children,Qa(t),r=Ht(r),s=s(r),t.flags|=1,Nt(e,t,s,l),t.child;case 14:return Xp(e,t,t.type,t.pendingProps,l);case 15:return Kp(e,t,t.type,t.pendingProps,l);case 19:return $f(e,t,l);case 31:return sb(e,t,l);case 22:return Pp(e,t,l,t.pendingProps);case 24:return Qa(t),s=Ht(vt),e===null?(r=tf(),r===null&&(r=et,f=Wc(),r.pooledCache=f,f.refCount++,f!==null&&(r.pooledCacheLanes|=l),r=f),t.memoizedState={parent:s,cache:r},lf(t),Kl(t,vt,r)):((e.lanes&l)!==0&&(af(e,t),fo(t,null,null,l),co()),r=e.memoizedState,f=t.memoizedState,r.parent!==s?(r={parent:s,cache:s},t.memoizedState=r,t.lanes===0&&(t.memoizedState=t.updateQueue.baseState=r),Kl(t,vt,s)):(s=f.cache,Kl(t,vt,s),s!==r.cache&&Jc(t,[vt],l,!0))),Nt(e,t,t.pendingProps.children,l),t.child;case 30:return t.stateNode===null&&(t.stateNode={autoName:null,paired:null,clones:null,ref:null}),s=t.pendingProps,s.name!=null&&s.name!=="auto"?t.flags|=e===null?18882560:18874368:Te&&Hr(t),e!==null&&e.memoizedProps.name!==s.name?t.flags|=4194816:Qs(e,t),Nt(e,t,s.children,l),t.child;case 29:throw t.pendingProps}throw Error(o(156,t.tag))}function Tl(e){e.flags|=4}function Ff(e,t,l,s,r){var f;if((f=(e.mode&32)!==0)&&(f=l===null?Lv(t,s):Lv(t,s)&&(s.src!==l.src||s.srcSet!==l.srcSet)),f){if(e.flags|=16777216,(r&335544128)===r)if(e.stateNode.complete)e.flags|=8192;else if(k0())e.flags|=8192;else throw Ka=Gr,nf}else e.flags&=-16777217}function o0(e,t){if(t.type!=="stylesheet"||(t.state.loading&4)!==0)e.flags&=-16777217;else if(e.flags|=16777216,!Hv(t))if(k0())e.flags|=8192;else throw Ka=Gr,nf}function ru(e,t){t!==null&&(e.flags|=4),e.flags&16384&&(t=e.tag!==22?qi():536870912,e.lanes|=t,Ps|=t)}function yo(e,t){if(!Te)switch(e.tailMode){case"visible":break;case"collapsed":for(var l=e.tail,s=null;l!==null;)l.alternate!==null&&(s=l),l=l.sibling;s===null?t||e.tail===null?e.tail=null:e.tail.sibling=null:s.sibling=null;break;default:for(t=e.tail,l=null;t!==null;)t.alternate!==null&&(l=t),t=t.sibling;l===null?e.tail=null:l.sibling=null}}function nt(e){var t=e.alternate!==null&&e.alternate.child===e.child,l=0,s=0;if(t)for(var r=e.child;r!==null;)l|=r.lanes|r.childLanes,s|=r.subtreeFlags&1206910976,s|=r.flags&1206910976,r.return=e,r=r.sibling;else for(r=e.child;r!==null;)l|=r.lanes|r.childLanes,s|=r.subtreeFlags,s|=r.flags,r.return=e,r=r.sibling;return e.subtreeFlags|=s,e.childLanes=l,t}function rb(e,t,l){var s=t.pendingProps;switch(Xc(t),t.tag){case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return nt(t),null;case 1:return nt(t),null;case 3:return l=t.stateNode,s=null,e!==null&&(s=e.memoizedState.cache),t.memoizedState.cache!==s&&(t.flags|=2048),Cl(vt),ut(),l.pendingContext&&(l.context=l.pendingContext,l.pendingContext=null),(e===null||e.child===null)&&($s(t)?Tl(t):e===null||e.memoizedState.isDehydrated&&(t.flags&256)===0||(t.flags|=1024,Pc())),nt(t),null;case 26:var r=t.type,f=t.memoizedState;return e===null?(Tl(t),f!==null?(nt(t),o0(t,f)):(nt(t),Ff(t,r,null,s,l))):f?f!==e.memoizedState?(Tl(t),nt(t),o0(t,f)):(nt(t),t.flags&=-16777217):(e=e.memoizedProps,e!==s&&Tl(t),nt(t),Ff(t,r,e,s,l)),null;case 27:if(Ot(t),l=Pt.current,r=t.type,e!==null&&t.stateNode!=null)e.memoizedProps!==s&&Tl(t);else{if(!s){if(t.stateNode===null)throw Error(o(166));return nt(t),t.subtreeFlags&=-33554433,null}e=Mt.current,$s(t)?Vg(t):(e=Mv(r,s,l),t.stateNode=e,Tl(t))}return nt(t),t.subtreeFlags&=-33554433,null;case 5:if(Ot(t),r=t.type,e!==null&&t.stateNode!=null)e.memoizedProps!==s&&Tl(t);else{if(!s){if(t.stateNode===null)throw Error(o(166));return nt(t),t.subtreeFlags&=-33554433,null}if(f=Mt.current,$s(t))Vg(t);else{var p=To(Pt.current);switch(f){case 1:f=p.createElementNS("http://www.w3.org/2000/svg",r);break;case 2:f=p.createElementNS("http://www.w3.org/1998/Math/MathML",r);break;default:switch(r){case"svg":f=p.createElementNS("http://www.w3.org/2000/svg",r);break;case"math":f=p.createElementNS("http://www.w3.org/1998/Math/MathML",r);break;case"script":f=p.createElement("div"),f.innerHTML="<script><\/script>",f=f.removeChild(f.firstChild);break;case"select":f=typeof s.is=="string"?p.createElement("select",{is:s.is}):p.createElement("select"),s.multiple?f.multiple=!0:s.size&&(f.size=s.size);break;default:f=typeof s.is=="string"?p.createElement(r,{is:s.is}):p.createElement(r)}}f[Lt]=t,f[sn]=s;e:for(p=t.child;p!==null;){if(p.tag===5||p.tag===6)f.appendChild(p.stateNode);else if(p.tag!==4&&p.tag!==27&&p.child!==null){p.child.return=p,p=p.child;continue}if(p===t)break e;for(;p.sibling===null;){if(p.return===null||p.return===t)break e;p=p.return}p.sibling.return=p.return,p=p.sibling}t.stateNode=f;e:switch(Ft(f,r,s),r){case"button":case"input":case"select":case"textarea":s=!!s.autoFocus;break e;case"img":s=!0;break e;default:s=!1}s&&Tl(t)}}return nt(t),t.subtreeFlags&=-33554433,Ff(t,t.type,e===null?null:e.memoizedProps,t.pendingProps,l),null;case 6:if(e&&t.stateNode!=null)e.memoizedProps!==s&&Tl(t);else{if(typeof s!="string"&&t.stateNode===null)throw Error(o(166));if(e=Pt.current,$s(t)){if(e=t.stateNode,l=t.memoizedProps,s=null,r=Tt,r!==null)switch(r.tag){case 27:case 5:s=r.memoizedProps}e[Lt]=t,e=!!(e.nodeValue===l||s!==null&&s.suppressHydrationWarning===!0||iv(e.nodeValue,l)),e||Xl(t,!0)}else e=To(e).createTextNode(s),e[Lt]=t,t.stateNode=e}return nt(t),null;case 31:if(l=t.memoizedState,e===null||e.memoizedState!==null){if(s=$s(t),l!==null){if(e===null){if(!s)throw Error(o(318));if(e=t.memoizedState,e=e!==null?e.dehydrated:null,!e)throw Error(o(557));e[Lt]=t}else Ba(),(t.flags&128)===0&&(t.memoizedState=null),t.flags|=4;nt(t),e=!1}else l=Pc(),e!==null&&e.memoizedState!==null&&(e.memoizedState.hydrationErrors=l),e=!0;if(!e)return t.flags&256?(vn(t),t):(vn(t),null);if((t.flags&128)!==0)throw Error(o(558))}return nt(t),null;case 13:if(s=t.memoizedState,e===null||e.memoizedState!==null&&e.memoizedState.dehydrated!==null){if(r=$s(t),s!==null&&s.dehydrated!==null){if(e===null){if(!r)throw Error(o(318));if(r=t.memoizedState,r=r!==null?r.dehydrated:null,!r)throw Error(o(317));r[Lt]=t}else Ba(),(t.flags&128)===0&&(t.memoizedState=null),t.flags|=4;nt(t),r=!1}else r=Pc(),e!==null&&e.memoizedState!==null&&(e.memoizedState.hydrationErrors=r),r=!0;if(!r)return t.flags&256?(vn(t),t):(vn(t),null)}return vn(t),(t.flags&128)!==0?(t.lanes=l,t):(l=s!==null,e=e!==null&&e.memoizedState!==null,l&&(s=t.child,r=null,s.alternate!==null&&s.alternate.memoizedState!==null&&s.alternate.memoizedState.cachePool!==null&&(r=s.alternate.memoizedState.cachePool.pool),f=null,s.memoizedState!==null&&s.memoizedState.cachePool!==null&&(f=s.memoizedState.cachePool.pool),f!==r&&(s.flags|=2048)),l!==e&&l&&(t.child.flags|=8192),ru(t,t.updateQueue),nt(t),null);case 4:return ut(),e===null&&bd(t.stateNode.containerInfo),t.flags|=67108864,nt(t),null;case 10:return Cl(t.type),nt(t),null;case 19:if(ff(t),s=t.memoizedState,s===null)return nt(t),null;if(r=(t.flags&128)!==0,f=s.rendering,f===null)if(r)yo(s,!1);else{if(ht!==0||e!==null&&(e.flags&128)!==0)for(e=t.child;e!==null;){if(f=Ir(e),f!==null){for(t.flags|=128,yo(s,!1),e=f.updateQueue,t.updateQueue=e,ru(t,e),t.subtreeFlags=0,e=l,l=t.child;l!==null;)Dg(l,e),l=l.sibling;return ho(t,$t.current&1|2),Te&&wl(t,s.treeForkCount),t.child}e=e.sibling}s.tail!==null&&We()>Su&&(t.flags|=128,r=!0,yo(s,!1),t.lanes=4194304)}else{if(!r)if(e=Ir(f),e!==null){if(t.flags|=128,r=!0,e=e.updateQueue,t.updateQueue=e,ru(t,e),yo(s,!0),s.tail===null&&s.tailMode!=="collapsed"&&s.tailMode!=="visible"&&!f.alternate&&!Te)return nt(t),null}else 2*We()-s.renderingStartTime>Su&&l!==536870912&&(t.flags|=128,r=!0,yo(s,!1),t.lanes=4194304);s.isBackwards?(f.sibling=t.child,t.child=f):(e=s.last,e!==null?e.sibling=f:t.child=f,s.last=f)}if(s.tail!==null){e=s.tail;e:{for(l=e;l!==null;){if(l.alternate!==null){l=!1;break e}l=l.sibling}l=!0}return s.rendering=e,s.tail=e.sibling,s.renderingStartTime=We(),e.sibling=null,f=$t.current,f=r?f&1|2:f&1,s.tailMode==="visible"||s.tailMode==="collapsed"||!l||Te?ho(t,f):(l=f,Ie(Ut,t),Ie($t,l),It===null&&(It=t)),Te&&wl(t,s.treeForkCount),e}return nt(t),null;case 22:case 23:return vn(t),uf(),s=t.memoizedState!==null,e!==null?e.memoizedState!==null!==s&&(t.flags|=8192):s&&(t.flags|=8192),s?(l&536870912)!==0&&(t.flags&128)===0&&(nt(t),t.subtreeFlags&6&&(t.flags|=8192)):nt(t),l=t.updateQueue,l!==null&&ru(t,l.retryQueue),l=null,e!==null&&e.memoizedState!==null&&e.memoizedState.cachePool!==null&&(l=e.memoizedState.cachePool.pool),s=null,t.memoizedState!==null&&t.memoizedState.cachePool!==null&&(s=t.memoizedState.cachePool.pool),s!==l&&(t.flags|=2048),e!==null&&mt(Ia),null;case 24:return l=null,e!==null&&(l=e.memoizedState.cache),t.memoizedState.cache!==l&&(t.flags|=2048),Cl(vt),nt(t),null;case 25:return null;case 30:return t.flags|=33554432,nt(t),null}throw Error(o(156,t.tag))}function ub(e,t){switch(Xc(t),t.tag){case 1:return e=t.flags,e&65536?(t.flags=e&-65537|128,t):null;case 3:return Cl(vt),ut(),e=t.flags,(e&65536)!==0&&(e&128)===0?(t.flags=e&-65537|128,t):null;case 26:case 27:case 5:return Ot(t),null;case 31:if(t.memoizedState!==null){if(vn(t),t.alternate===null)throw Error(o(340));Ba()}return e=t.flags,e&65536?(t.flags=e&-65537|128,t):null;case 13:if(vn(t),e=t.memoizedState,e!==null&&e.dehydrated!==null){if(t.alternate===null)throw Error(o(340));Ba()}return e=t.flags,e&65536?(t.flags=e&-65537|128,t):null;case 19:return ff(t),e=t.flags,e&65536?(t.flags=e&-65537|128,e=t.memoizedState,e!==null&&(e.rendering=null,e.tail=null),t.flags|=4,t):null;case 4:return ut(),null;case 10:return Cl(t.type),null;case 22:case 23:return vn(t),uf(),e!==null&&mt(Ia),e=t.flags,e&65536?(t.flags=e&-65537|128,t):null;case 24:return Cl(vt),null;case 25:return null;default:return null}}function r0(e,t){switch(Xc(t),t.tag){case 3:Cl(vt),ut();break;case 26:case 27:case 5:Ot(t);break;case 4:ut();break;case 31:t.memoizedState!==null&&vn(t);break;case 13:vn(t);break;case 19:ff(t);break;case 10:Cl(t.type);break;case 22:case 23:vn(t),uf(),e!==null&&mt(Ia);break;case 24:Cl(vt)}}function xo(e,t){try{var l=t.updateQueue,s=l!==null?l.lastEffect:null;if(s!==null){var r=s.next;l=r;do{if((l.tag&e)===e){s=void 0;var f=l.create,p=l.inst;s=f(),p.destroy=s}l=l.next}while(l!==r)}}catch(b){Pe(t,t.return,b)}}function la(e,t,l){try{var s=t.updateQueue,r=s!==null?s.lastEffect:null;if(r!==null){var f=r.next;s=f;do{if((s.tag&e)===e){var p=s.inst,b=p.destroy;if(b!==void 0){p.destroy=void 0,r=t;var T=l,B=b;try{B()}catch(I){Pe(r,T,I)}}}s=s.next}while(s!==f)}}catch(I){Pe(t,t.return,I)}}function u0(e){var t=e.updateQueue;if(t!==null){var l=e.stateNode;try{Jg(t,l)}catch(s){Pe(e,e.return,s)}}}function c0(e,t,l){l.props=Ja(e.type,e.memoizedProps),l.state=e.memoizedState;try{l.componentWillUnmount()}catch(s){Pe(e,t,s)}}function nl(e,t){try{var l=e.ref;if(l!==null){switch(e.tag){case 26:case 27:case 5:var s=e.stateNode;break;case 30:var r=e.stateNode,f=Sl(e.memoizedProps,r);(r.ref===null||r.ref.name!==f)&&(r.ref=vv(f)),s=r.ref;break;case 7:if(e.stateNode===null){var p=new jn(e);v(e.child,!1,Wb,p,void 0,void 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cs,hx,Ax=(hx=class{constructor(){ye(this,cs)}destroy(){this.clearGcTimeout()}scheduleGc(){this.clearGcTimeout(),wx(this.gcTime)&&ce(this,cs,rs.setTimeout(()=>{this.optionalRemove()},this.gcTime))}updateGcTime(n){this.gcTime=Math.max(this.gcTime||0,n??(xm()?1/0:3e5))}clearGcTimeout(){U(this,cs)!==void 0&&(rs.clearTimeout(U(this,cs)),ce(this,cs,void 0))}},cs=new WeakMap,hx);function sj(n){return{onFetch:(a,i)=>{var x,v,S,w,j;const o=a.options,u=(S=(v=(x=a.fetchOptions)==null?void 0:x.meta)==null?void 0:v.fetchMore)==null?void 0:S.direction,d=((w=a.state.data)==null?void 0:w.pages)||[],h=((j=a.state.data)==null?void 0:j.pageParams)||[];let m={pages:[],pageParams:[]},g=0;const y=async()=>{let N=!1;const M=D=>{J2(D,()=>a.signal,()=>N=!0)},A=Mx(a.options,a.fetchOptions),C=async(D,O,z)=>{if(N)return Promise.reject(a.signal.reason);if(O==null&&D.pages.length)return Promise.resolve(D);const R=(()=>{const 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Proxy(a,{get:(o,u)=>(this.trackProp(u),i==null||i(u),Reflect.get(o,u))})}trackProp(a){U(this,Di).add(a)}getCurrentQuery(){return U(this,Le)}refetch({...a}={}){return this.fetch({...a})}fetchOptimistic(a){const i=U(this,nn).defaultQueryOptions(a),o=U(this,nn).getQueryCache().build(U(this,nn),i);let u=()=>{},d;const h=new Promise(m=>{d=m,u=U(this,nn).getQueryCache().subscribe(g=>{g.type==="updated"&&g.query.queryHash===o.queryHash&&o.state.data!==void 0&&(u(),m(this.createResult(o,i)))})});return Promise.race([o.fetch(i).then(()=>{const m=this.createResult(o,i);return d==null||d(m),m}).finally(()=>{u()}),h])}fetch(a){return De(this,Qe,Ko).call(this,{...a,cancelRefetch:a.cancelRefetch??!0}).then(()=>(this.updateResult(),U(this,ln)))}createResult(a,i){var _;const o=U(this,Le),u=this.options,d=U(this,ln),h=U(this,ms),m=U(this,Ai),g=a!==o?a.state:U(this,ir),{state:y}=a;let x={...y},v=!1,S;if(i._optimisticResults){const R=this.hasListeners(),Q=!R&&py(a,i),K=R&&vy(a,o,i,u);(Q||K)&&(x={...x,...zx(y.data,a.options)}),i._optimisticResults==="isRestoring"&&(x.fetchStatus="idle")}let{error:w,errorUpdatedAt:j,status:N}=x;S=x.data;let M=!1;if(i.placeholderData!==void 0&&S===void 0&&N==="pending"){let R;d!=null&&d.isPlaceholderData&&i.placeholderData===(m==null?void 0:m.placeholderData)?(R=d.data,M=!0):R=typeof i.placeholderData=="function"?i.placeholderData((_=U(this,zi))==null?void 0:_.state.data,U(this,zi)):i.placeholderData,R!==void 0&&(N="success",S=Hh(d==null?void 0:d.data,R,i),v=!0)}if(i.select&&S!==void 0&&!M)if(d&&S===(h==null?void 0:h.data)&&i.select===U(this,or))S=U(this,Oi);else try{ce(this,or,i.select),S=i.select(S),S=Hh(d==null?void 0:d.data,S,i),ce(this,Oi,S),ce(this,Hl,null)}catch(R){ce(this,Hl,R)}else S===void 0&&ce(this,Hl,null);U(this,Hl)&&(w=U(this,Hl),S=U(this,Oi),j=Date.now(),N="error",v=!1);const A=x.fetchStatus==="fetching",C=N==="pending",D=N==="error",O=C&&A,z=S!==void 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this.options.throwOnError&&m.add("error"),Object.keys(U(this,ln)).some(g=>{const y=g;return U(this,ln)[y]!==a[y]&&m.has(y)})})();Bt.batch(()=>{u&&this.listeners.forEach(d=>{d(U(this,ln))}),U(this,nn).getQueryCache().notify({query:U(this,Le),type:"observerResultsUpdated"})})}onQueryUpdate(){this.updateResult(),this.hasListeners()&&De(this,Qe,Gh).call(this)}},nn=new WeakMap,Le=new WeakMap,ir=new WeakMap,ln=new WeakMap,ms=new WeakMap,Ai=new WeakMap,Hl=new WeakMap,or=new WeakMap,Oi=new WeakMap,zi=new WeakMap,gs=new WeakMap,ps=new WeakMap,ja=new WeakMap,Di=new WeakMap,Qe=new WeakSet,Ko=function(a){De(this,Qe,Yh).call(this);let i=U(this,Le).fetch(this.options,a);return a!=null&&a.throwOnError||(i=i.catch(hn)),i},Vh=function(a){return!xm()&&ot(this.options.enabled,U(this,Le))!==!1&&wx(a)},Fh=function(){De(this,Qe,qh).call(this);const a=ot(this.options.staleTime,U(this,Le));if(U(this,ln).isStale||!De(this,Qe,Vh).call(this,a))return;const i=Nx(U(this,ln).dataUpdatedAt,a)+1;ce(this,gs,rs.setTimeout(()=>{U(this,ln).isStale||this.updateResult()},i))},kh=function(){return ot(this.options.refetchInterval,U(this,Le))??!1},Bh=function(a){De(this,Qe,Qh).call(this),ce(this,ja,a),!(U(this,ja)===0||!De(this,Qe,Vh).call(this,U(this,ja)))&&ce(this,ps,rs.setInterval(()=>{(this.options.refetchIntervalInBackground||Sm.isFocused())&&De(this,Qe,Ko).call(this)},U(this,ja)))},Gh=function(){De(this,Qe,Fh).call(this),De(this,Qe,Bh).call(this,De(this,Qe,kh).call(this))},qh=function(){U(this,gs)!==void 0&&(rs.clearTimeout(U(this,gs)),ce(this,gs,void 0))},Qh=function(){U(this,ps)!==void 0&&(rs.clearInterval(U(this,ps)),ce(this,ps,void 0))},Yh=function(){const a=U(this,nn).getQueryCache().build(U(this,nn),this.options);if(a===U(this,Le))return;const i=U(this,Le);ce(this,Le,a),ce(this,ir,a.state),this.hasListeners()&&(i==null||i.removeObserver(this),a.addObserver(this))},gx);function uj(n,a){return ot(a.enabled,n)!==!1&&n.state.data===void 0&&!(n.state.status==="error"&&ot(a.retryOnMount,n)===!1)}function py(n,a){return uj(n,a)||n.state.data!==void 0&&Ih(n,a,a.refetchOnMount)}function Ih(n,a,i){if(ot(a.enabled,n)!==!1&&ot(a.staleTime,n)!=="static"){const o=ot(i,n);return o==="always"||o!==!1&&bm(n,a)}return!1}function vy(n,a,i,o){return(n!==a||ot(o.enabled,n)===!1)&&(!i.suspense||n.state.status!=="error")&&bm(n,i)}function bm(n,a){return ot(a.enabled,n)!==!1&&n.isStaleByTime(ot(a.staleTime,n))}var cj=class extends Dx{constructor(n,a){super(n,a)}bindMethods(){super.bindMethods(),this.fetchNextPage=this.fetchNextPage.bind(this),this.fetchPreviousPage=this.fetchPreviousPage.bind(this)}setOptions(n){n._type="infinite",super.setOptions(n)}getOptimisticResult(n){return n._type="infinite",super.getOptimisticResult(n)}fetchNextPage(n){return this.fetch({...n,meta:{fetchMore:{direction:"forward"}}})}fetchPreviousPage(n){return this.fetch({...n,meta:{fetchMore:{direction:"backward"}}})}createResult(n,a){var w,j;const{state:i}=n,o=super.createResult(n,a),{isFetching:u,isRefetching:d,isError:h,isRefetchError:m}=o,g=(j=(w=i.fetchMeta)==null?void 0:w.fetchMore)==null?void 0:j.direction,y=h&&g==="forward",x=u&&g==="forward",v=h&&g==="backward",S=u&&g==="backward";return{...o,fetchNextPage:this.fetchNextPage,fetchPreviousPage:this.fetchPreviousPage,hasNextPage:ij(a,i.data),hasPreviousPage:oj(a,i.data),isFetchNextPageError:y,isFetchingNextPage:x,isFetchPreviousPageError:v,isFetchingPreviousPage:S,isRefetchError:m&&!y&&!v,isRefetching:d&&!x&&!S}}},rr,cl,Kt,vs,fl,pa,px,fj=(px=class extends Ax{constructor(a){super();ye(this,fl);ye(this,rr);ye(this,cl);ye(this,Kt);ye(this,vs);ce(this,rr,a.client),this.mutationId=a.mutationId,ce(this,Kt,a.mutationCache),ce(this,cl,[]),this.state=a.state||dj(),this.setOptions(a.options),this.scheduleGc()}setOptions(a){this.options=a,this.updateGcTime(this.options.gcTime)}get meta(){return this.options.meta}addObserver(a){U(this,cl).includes(a)||(U(this,cl).push(a),this.clearGcTimeout(),U(this,Kt).notify({type:"observerAdded",mutation:this,observer:a}))}removeObserver(a){ce(this,cl,U(this,cl).filter(i=>i!==a)),this.scheduleGc(),U(this,Kt).notify({type:"observerRemoved",mutation:this,observer:a})}optionalRemove(){U(this,cl).length||(this.state.status==="pending"?this.scheduleGc():U(this,Kt).remove(this))}continue(){var a;return((a=U(this,vs))==null?void 0:a.continue())??(this.state.status==="pending"?this.execute(this.state.variables):Promise.resolve())}async execute(a){var m,g,y,x,v,S,w,j,N,M,A,C,D,O,z,_,R,Q;const i=()=>{De(this,fl,pa).call(this,{type:"continue"})},o={client:U(this,rr),meta:this.options.meta,mutationKey:this.options.mutationKey},u=ce(this,vs,Rx({fn:()=>this.options.mutationFn?this.options.mutationFn(a,o):Promise.reject(new Error("No mutationFn found")),onFail:(K,$)=>{De(this,fl,pa).call(this,{type:"failed",failureCount:K,error:$})},onPause:()=>{De(this,fl,pa).call(this,{type:"pause"})},onContinue:i,retry:this.options.retry??0,retryDelay:this.options.retryDelay,networkMode:this.options.networkMode,canRun:()=>U(this,Kt).canRun(this)})),d=this.state.status==="pending",h=!u.canStart();try{if(d)i();else{De(this,fl,pa).call(this,{type:"pending",variables:a,isPaused:h}),U(this,Kt).config.onMutate&&await U(this,Kt).config.onMutate(a,this,o);const $=await((g=(m=this.options).onMutate)==null?void 0:g.call(m,a,o));$!==this.state.context&&De(this,fl,pa).call(this,{type:"pending",context:$,variables:a,isPaused:h})}const K=await u.start();return await((x=(y=U(this,Kt).config).onSuccess)==null?void 0:x.call(y,K,a,this.state.context,this,o)),await((S=(v=this.options).onSuccess)==null?void 0:S.call(v,K,a,this.state.context,o)),await((j=(w=U(this,Kt).config).onSettled)==null?void 0:j.call(w,K,null,this.state.variables,this.state.context,this,o)),await((M=(N=this.options).onSettled)==null?void 0:M.call(N,K,null,a,this.state.context,o)),De(this,fl,pa).call(this,{type:"success",data:K}),K}catch(K){try{await((C=(A=U(this,Kt).config).onError)==null?void 0:C.call(A,K,a,this.state.context,this,o))}catch($){Promise.reject($)}try{await((O=(D=this.options).onError)==null?void 0:O.call(D,K,a,this.state.context,o))}catch($){Promise.reject($)}try{await((_=(z=U(this,Kt).config).onSettled)==null?void 0:_.call(z,void 0,K,this.state.variables,this.state.context,this,o))}catch($){Promise.reject($)}try{await((Q=(R=this.options).onSettled)==null?void 0:Q.call(R,void 0,K,a,this.state.context,o))}catch($){Promise.reject($)}throw De(this,fl,pa).call(this,{type:"error",error:K}),K}finally{U(this,vs)===u&&ce(this,vs,void 0),U(this,Kt).runNext(this)}}},rr=new WeakMap,cl=new WeakMap,Kt=new WeakMap,vs=new WeakMap,fl=new WeakSet,pa=function(a){const i=o=>{switch(a.type){case"failed":return{...o,failureCount:a.failureCount,failureReason:a.error};case"pause":return{...o,isPaused:!0};case"continue":return{...o,isPaused:!1};case"pending":return{...o,context:a.context,data:void 0,failureCount:0,failureReason:null,error:null,isPaused:a.isPaused,status:"pending",variables:a.variables,submittedAt:Date.now()};case"success":return{...o,data:a.data,failureCount:0,failureReason:null,error:null,status:"success",isPaused:!1};case"error":return{...o,data:void 0,error:a.error,failureCount:o.failureCount+1,failureReason:a.error,isPaused:!1,status:"error"}}};this.state=i(this.state),Bt.batch(()=>{U(this,cl).forEach(o=>{o.onMutationUpdate(a)}),U(this,Kt).notify({mutation:this,type:"updated",action:a})})},px);function dj(){return{context:void 0,data:void 0,error:null,failureCount:0,failureReason:null,isPaused:!1,status:"idle",variables:void 0,submittedAt:0}}var wa,In,ur,vx,hj=(vx=class extends cr{constructor(a={}){super();ye(this,wa);ye(this,In);ye(this,ur);this.config=a,ce(this,wa,new Set),ce(this,In,new Map),ce(this,ur,0)}build(a,i,o){const u=new fj({client:a,mutationCache:this,mutationId:++ku(this,ur)._,options:a.defaultMutationOptions(i),state:o});return this.add(u),u}add(a){U(this,wa).add(a);const i=Bu(a);if(typeof i=="string"){const o=U(this,In).get(i);o?o.push(a):U(this,In).set(i,[a])}this.notify({type:"added",mutation:a})}remove(a){if(U(this,wa).delete(a)){const i=Bu(a);if(typeof i=="string"){const o=U(this,In).get(i);if(o)if(o.length>1){const u=o.indexOf(a);u!==-1&&o.splice(u,1)}else o[0]===a&&U(this,In).delete(i)}}this.notify({type:"removed",mutation:a})}canRun(a){var o;const i=Bu(a);if(typeof i=="string"){const u=(o=U(this,In).get(i))==null?void 0:o.find(d=>d.state.status==="pending");return!u||u===a}else return!0}runNext(a){var o,u;const i=Bu(a);return typeof i=="string"?((u=(o=U(this,In).get(i))==null?void 0:o.find(d=>d!==a&&d.state.isPaused))==null?void 0:u.continue())??Promise.resolve():Promise.resolve()}clear(){Bt.batch(()=>{const a=this.getAll();U(this,wa).clear(),U(this,In).clear(),a.forEach(i=>{this.notify({type:"removed",mutation:i})})})}getAll(){return Array.from(U(this,wa))}find(a){const i={exact:!0,...a};return this.getAll().find(o=>fy(i,o))}findAll(a={}){return this.getAll().filter(i=>fy(a,i))}notify(a){Bt.batch(()=>{this.listeners.forEach(i=>{i(a)})})}resumePausedMutations(){const a=this.getAll().filter(i=>i.state.isPaused);return Bt.batch(()=>Promise.all(a.map(i=>i.continue().catch(hn))))}},wa=new WeakMap,In=new WeakMap,ur=new WeakMap,vx);function Bu(n){var a;return(a=n.options.scope)==null?void 0:a.id}var dl,yx,mj=(yx=class extends cr{constructor(a={}){super();ye(this,dl);this.config=a,ce(this,dl,new Map)}build(a,i,o){const u=i.queryKey,d=i.queryHash??vm(u,i);let h=this.get(d);return h||(h=new rj({client:a,queryKey:u,queryHash:d,options:a.defaultQueryOptions(i),state:o,defaultOptions:a.getQueryDefaults(u)}),this.add(h)),h}add(a){U(this,dl).has(a.queryHash)||(U(this,dl).set(a.queryHash,a),this.notify({type:"added",query:a}))}remove(a){U(this,dl).get(a.queryHash)===a&&(a.destroy(),U(this,dl).delete(a.queryHash),this.notify({type:"removed",query:a}))}clear(){Bt.batch(()=>{this.getAll().forEach(a=>{this.remove(a)})})}get(a){return U(this,dl).get(a)}getAll(){return[...U(this,dl).values()]}find(a){const i={exact:!0,...a};return this.getAll().find(o=>cy(i,o))}findAll(a={}){const i=this.getAll();return Object.keys(a).length>0?i.filter(o=>cy(a,o)):i}notify(a){Bt.batch(()=>{this.listeners.forEach(i=>{i(a)})})}onFocus(){Bt.batch(()=>{this.getAll().forEach(a=>{a.onFocus()})})}onOnline(){Bt.batch(()=>{this.getAll().forEach(a=>{a.onOnline()})})}},dl=new WeakMap,yx),ft,Na,Ca,Li,Hi,Ea,Ui,$i,xx,gj=(xx=class{constructor(n={}){ye(this,ft);ye(this,Na);ye(this,Ca);ye(this,Li);ye(this,Hi);ye(this,Ea);ye(this,Ui);ye(this,$i);ce(this,ft,n.queryCache||new mj),ce(this,Na,n.mutationCache||new hj),ce(this,Ca,n.defaultOptions||{}),ce(this,Li,new Map),ce(this,Hi,new Map),ce(this,Ea,0)}mount(){ku(this,Ea)._++,U(this,Ea)===1&&(ce(this,Ui,Sm.subscribe(async n=>{n&&(await this.resumePausedMutations(),U(this,ft).onFocus())})),ce(this,$i,Zu.subscribe(async n=>{n&&(await this.resumePausedMutations(),U(this,ft).onOnline())})))}unmount(){var n,a;ku(this,Ea)._--,U(this,Ea)===0&&((n=U(this,Ui))==null||n.call(this),ce(this,Ui,void 0),(a=U(this,$i))==null||a.call(this),ce(this,$i,void 0))}isFetching(n){return U(this,ft).findAll({...n,fetchStatus:"fetching"}).length}isMutating(n){return U(this,Na).findAll({...n,status:"pending"}).length}getQueryData(n){var i;const a=this.defaultQueryOptions({queryKey:n});return(i=U(this,ft).get(a.queryHash))==null?void 0:i.state.data}ensureQueryData(n){const a=this.defaultQueryOptions(n),i=U(this,ft).build(this,a),o=i.state.data;return o===void 0?this.fetchQuery(n):(n.revalidateIfStale&&i.isStaleByTime(ot(a.staleTime,i))&&this.prefetchQuery(a),Promise.resolve(o))}getQueriesData(n){return U(this,ft).findAll(n).map(({queryKey:a,state:i})=>[a,i.data])}setQueryData(n,a,i){var h;const o=this.defaultQueryOptions({queryKey:n}),u=(h=U(this,ft).get(o.queryHash))==null?void 0:h.state.data,d=I2(a,u);if(d!==void 0)return U(this,ft).build(this,o).setData(d,{...i,manual:!0})}setQueriesData(n,a,i){return Bt.batch(()=>U(this,ft).findAll(n).map(({queryKey:o})=>[o,this.setQueryData(o,a,i)]))}getQueryState(n){var i;const a=this.defaultQueryOptions({queryKey:n});return(i=U(this,ft).get(a.queryHash))==null?void 0:i.state}removeQueries(n){const a=U(this,ft);Bt.batch(()=>{a.findAll(n).forEach(i=>{a.remove(i)})})}resetQueries(n,a){const i=U(this,ft);return Bt.batch(()=>{const o=i.findAll(n),u=new Set(o);return o.forEach(d=>{d.reset()}),this.refetchQueries({type:"active",predicate:d=>u.has(d)},a)})}cancelQueries(n,a={}){const i={revert:!0,...a},o=Bt.batch(()=>U(this,ft).findAll(n).map(u=>u.cancel(i)));return Promise.all(o).then(hn).catch(hn)}invalidateQueries(n,a={}){return Bt.batch(()=>(U(this,ft).findAll(n).forEach(i=>{i.invalidate()}),(n==null?void 0:n.refetchType)==="none"?Promise.resolve():this.refetchQueries({...n,type:(n==null?void 0:n.refetchType)??(n==null?void 0:n.type)??"active"},a)))}refetchQueries(n,a={}){const i={...a,cancelRefetch:a.cancelRefetch??!0},o=Bt.batch(()=>U(this,ft).findAll(n).filter(u=>!u.isDisabled()&&!u.isStatic()).map(u=>{let d=u.fetch(void 0,i);return i.throwOnError||(d=d.catch(hn)),u.state.fetchStatus==="paused"?Promise.resolve():d}));return Promise.all(o).then(hn)}async query(n){const a=this.defaultQueryOptions(n);a.retry===void 0&&(a.retry=!1);const i=U(this,ft).build(this,a),o=i.isStaleByTime(ot(a.staleTime,i))?await i.fetch(a):i.state.data,u=a.select;return u?u(o):o}fetchQuery(n){const a=this.defaultQueryOptions(n);a.retry===void 0&&(a.retry=!1);const i=U(this,ft).build(this,a);return i.isStaleByTime(ot(a.staleTime,i))?i.fetch(a):Promise.resolve(i.state.data)}prefetchQuery(n){return this.fetchQuery(n).then(hn).catch(hn)}infiniteQuery(n){return n._type="infinite",this.query(n)}fetchInfiniteQuery(n){return n._type="infinite",this.fetchQuery(n)}prefetchInfiniteQuery(n){return this.fetchInfiniteQuery(n).then(hn).catch(hn)}ensureInfiniteQueryData(n){return n._type="infinite",this.ensureQueryData(n)}resumePausedMutations(){return Zu.isOnline()?U(this,Na).resumePausedMutations():Promise.resolve()}getQueryCache(){return U(this,ft)}getMutationCache(){return U(this,Na)}getDefaultOptions(){return U(this,Ca)}setDefaultOptions(n){ce(this,Ca,n)}setQueryDefaults(n,a){U(this,Li).set(er(n),{queryKey:n,defaultOptions:a})}getQueryDefaults(n){const a=[...U(this,Li).values()],i={};return a.forEach(o=>{Vi(n,o.queryKey)&&Object.assign(i,o.defaultOptions)}),i}setMutationDefaults(n,a){U(this,Hi).set(er(n),{mutationKey:n,defaultOptions:a})}getMutationDefaults(n){const a=[...U(this,Hi).values()],i={};return a.forEach(o=>{Vi(n,o.mutationKey)&&Object.assign(i,o.defaultOptions)}),i}defaultQueryOptions(n){if(n._defaulted)return n;const a={...U(this,Ca).queries,...this.getQueryDefaults(n.queryKey),...n,_defaulted:!0};return a.queryHash||(a.queryHash=vm(a.queryKey,a)),a.refetchOnReconnect===void 0&&(a.refetchOnReconnect=a.networkMode!=="always"),a.throwOnError===void 0&&(a.throwOnError=!!a.suspense),!a.networkMode&&a.persister&&(a.networkMode="offlineFirst"),a.queryFn===ym&&(a.enabled=!1),a}defaultMutationOptions(n){return n!=null&&n._defaulted?n:{...U(this,Ca).mutations,...(n==null?void 0:n.mutationKey)&&this.getMutationDefaults(n.mutationKey),...n,_defaulted:!0}}clear(){U(this,ft).clear(),U(this,Na).clear()}},ft=new WeakMap,Na=new WeakMap,Ca=new WeakMap,Li=new WeakMap,Hi=new WeakMap,Ea=new WeakMap,Ui=new WeakMap,$i=new WeakMap,xx);const Lx=E.createContext(!1),pj=()=>E.useContext(Lx);Lx.Provider;function vj(){let n=!1;return{clearReset:()=>{n=!1},reset:()=>{n=!0},isReset:()=>n}}const yj=E.createContext(vj()),xj=()=>E.useContext(yj),Sj=(n,a,i)=>{const o=(i==null?void 0:i.state.status)==="error"&&typeof n.throwOnError=="function"?_x(n.throwOnError,[i.state.error,i]):n.throwOnError;(n.suspense||o)&&(a.isReset()||(n.retryOnMount=!1))},bj=n=>{E.useEffect(()=>{n.clearReset()},[n])},jj=({result:n,errorResetBoundary:a,throwOnError:i,query:o,suspense:u})=>n.isError&&!a.isReset()&&!n.isFetching&&o&&(u&&n.data===void 0||_x(i,[n.error,o])),wj=n=>{if(n.suspense){const i=u=>u==="static"?u:Math.max(u??1e3,1e3),o=n.staleTime;n.staleTime=typeof o=="function"?(...u)=>i(o(...u)):i(o),typeof n.gcTime=="number"&&(n.gcTime=Math.max(n.gcTime,1e3))}},Nj=(n,a)=>(n==null?void 0:n.suspense)&&a.isPending,Cj=(n,a,i)=>a.fetchOptimistic(n).catch(()=>{i.clearReset()});function Hx(n,a,i){const o=pj(),u=xj(),d=jx(),h=d.defaultQueryOptions(n),m=d.getQueryCache().get(h.queryHash),g=n.subscribed!==!1;h._optimisticResults=o?"isRestoring":g?"optimistic":void 0,wj(h),Sj(h,u,m),bj(u);const[y]=E.useState(()=>new a(d,h)),x=y.getOptimisticResult(h),v=!o&&g;if(E.useSyncExternalStore(E.useCallback(S=>{const w=v?y.subscribe(Bt.batchCalls(S)):hn;return y.updateResult(),w},[y,v]),()=>y.getCurrentResult(),()=>y.getCurrentResult()),E.useEffect(()=>{y.setOptions(h)},[h,y]),Nj(h,x))throw Cj(h,y,u);if(jj({result:x,errorResetBoundary:u,throwOnError:h.throwOnError,query:m,suspense:h.suspense}))throw x.error;return h.notifyOnChangeProps?x:y.trackResult(x)}function Un(n,a){return Hx(n,Dx)}function Ej(n,a){return Hx(n,cj)}var jm=Sx();/**
  * @remix-run/router v1.23.4
  *
  * Copyright (c) Remix Software Inc.
@@ -55,7 +55,7 @@ Error generating stack: `+a.message+`
  * LICENSE.md file in the root directory of this source tree.
  *
  * @license MIT
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@@ -64,7 +64,7 @@ Error generating stack: `+a.message+`
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u&&u.static&&u.staticContext&&(i.route.errorElement||i.route.ErrorBoundary)&&(u.staticContext._deepestRenderedBoundaryId=i.route.id),E.createElement(bs.Provider,{value:a},o)}function rw(n,a,i,o){var u;if(a===void 0&&(a=[]),i===void 0&&(i=null),o===void 0&&(o=null),n==null){var d;if(!i)return null;if(i.errors)n=i.matches;else if((d=o)!=null&&d.v7_partialHydration&&a.length===0&&!i.initialized&&i.matches.length>0)n=i.matches;else return null}let h=n,m=(u=i)==null?void 0:u.errors;if(m!=null){let x=h.findIndex(v=>v.route.id&&(m==null?void 0:m[v.route.id])!==void 0);x>=0||bt(!1),h=h.slice(0,Math.min(h.length,x+1))}let g=!1,y=-1;if(i&&o&&o.v7_partialHydration)for(let x=0;x<h.length;x++){let v=h[x];if((v.route.HydrateFallback||v.route.hydrateFallbackElement)&&(y=x),v.route.id){let{loaderData:S,errors:w}=i,j=v.route.loader&&S[v.route.id]===void 0&&(!w||w[v.route.id]===void 0);if(v.route.lazy||j){g=!0,y>=0?h=h.slice(0,y+1):h=[h[0]];break}}}return h.reduceRight((x,v,S)=>{let 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@@ -73,198 +73,198 @@ Error generating stack: `+a.message+`
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  *
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- */const Fu=Ve("ArrowDown",[["path",{d:"M12 5v14",key:"s699le"}],["path",{d:"m19 12-7 7-7-7",key:"1idqje"}]]);/**
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- */const hj=Ve("ArrowUpRight",[["path",{d:"M7 7h10v10",key:"1tivn9"}],["path",{d:"M7 17 17 7",key:"1vkiza"}]]);/**
+ */const _w=$e("ArrowUpRight",[["path",{d:"M7 7h10v10",key:"1tivn9"}],["path",{d:"M7 17 17 7",key:"1vkiza"}]]);/**
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- */const Ux=Ve("ArrowUp",[["path",{d:"m5 12 7-7 7 7",key:"hav0vg"}],["path",{d:"M12 19V5",key:"x0mq9r"}]]);/**
+ */const Wx=$e("ArrowUp",[["path",{d:"m5 12 7-7 7 7",key:"hav0vg"}],["path",{d:"M12 19V5",key:"x0mq9r"}]]);/**
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  * See the LICENSE file in the root directory of this source tree.
- */const Vx=Ve("Check",[["path",{d:"M20 6 9 17l-5-5",key:"1gmf2c"}]]);/**
+ */const e1=$e("Check",[["path",{d:"M20 6 9 17l-5-5",key:"1gmf2c"}]]);/**
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  * See the LICENSE file in the root directory of this source tree.
- */const $x=Ve("ChevronDown",[["path",{d:"m6 9 6 6 6-6",key:"qrunsl"}]]);/**
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  * See the LICENSE file in the root directory of this source tree.
- */const dm=Ve("ChevronRight",[["path",{d:"m9 18 6-6-6-6",key:"mthhwq"}]]);/**
+ */const Cm=$e("ChevronRight",[["path",{d:"m9 18 6-6-6-6",key:"mthhwq"}]]);/**
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  * See the LICENSE file in the root directory of this source tree.
- */const pj=Ve("CircleAlert",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"12",x2:"12",y1:"8",y2:"12",key:"1pkeuh"}],["line",{x1:"12",x2:"12.01",y1:"16",y2:"16",key:"4dfq90"}]]);/**
+ */const Aw=$e("CircleAlert",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"12",x2:"12",y1:"8",y2:"12",key:"1pkeuh"}],["line",{x1:"12",x2:"12.01",y1:"16",y2:"16",key:"4dfq90"}]]);/**
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  *
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  * See the LICENSE file in the root directory of this source tree.
- */const vj=Ve("CircleCheck",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"m9 12 2 2 4-4",key:"dzmm74"}]]);/**
+ */const Ow=$e("CircleCheck",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"m9 12 2 2 4-4",key:"dzmm74"}]]);/**
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  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const yj=Ve("CircleDashed",[["path",{d:"M10.1 2.182a10 10 0 0 1 3.8 0",key:"5ilxe3"}],["path",{d:"M13.9 21.818a10 10 0 0 1-3.8 0",key:"11zvb9"}],["path",{d:"M17.609 3.721a10 10 0 0 1 2.69 2.7",key:"1iw5b2"}],["path",{d:"M2.182 13.9a10 10 0 0 1 0-3.8",key:"c0bmvh"}],["path",{d:"M20.279 17.609a10 10 0 0 1-2.7 2.69",key:"1ruxm7"}],["path",{d:"M21.818 10.1a10 10 0 0 1 0 3.8",key:"qkgqxc"}],["path",{d:"M3.721 6.391a10 10 0 0 1 2.7-2.69",key:"1mcia2"}],["path",{d:"M6.391 20.279a10 10 0 0 1-2.69-2.7",key:"1fvljs"}]]);/**
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  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Fx=Ve("Copy",[["rect",{width:"14",height:"14",x:"8",y:"8",rx:"2",ry:"2",key:"17jyea"}],["path",{d:"M4 16c-1.1 0-2-.9-2-2V4c0-1.1.9-2 2-2h10c1.1 0 2 .9 2 2",key:"zix9uf"}]]);/**
+ */const n1=$e("Copy",[["rect",{width:"14",height:"14",x:"8",y:"8",rx:"2",ry:"2",key:"17jyea"}],["path",{d:"M4 16c-1.1 0-2-.9-2-2V4c0-1.1.9-2 2-2h10c1.1 0 2 .9 2 2",key:"zix9uf"}]]);/**
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  * See the LICENSE file in the root directory of this source tree.
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+ */const Wh=$e("Crosshair",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"22",x2:"18",y1:"12",y2:"12",key:"l9bcsi"}],["line",{x1:"6",x2:"2",y1:"12",y2:"12",key:"13hhkx"}],["line",{x1:"12",x2:"12",y1:"6",y2:"2",key:"10w3f3"}],["line",{x1:"12",x2:"12",y1:"22",y2:"18",key:"15g9kq"}]]);/**
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  * See the LICENSE file in the root directory of this source tree.
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  * See the LICENSE file in the root directory of this source tree.
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  *
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  * See the LICENSE file in the root directory of this source tree.
- */const xj=Ve("FolderOpen",[["path",{d:"m6 14 1.5-2.9A2 2 0 0 1 9.24 10H20a2 2 0 0 1 1.94 2.5l-1.54 6a2 2 0 0 1-1.95 1.5H4a2 2 0 0 1-2-2V5a2 2 0 0 1 2-2h3.9a2 2 0 0 1 1.69.9l.81 1.2a2 2 0 0 0 1.67.9H18a2 2 0 0 1 2 2v2",key:"usdka0"}]]);/**
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+ */const Lw=$e("Info",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"M12 16v-4",key:"1dtifu"}],["path",{d:"M12 8h.01",key:"e9boi3"}]]);/**
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  *
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  * See the LICENSE file in the root directory of this source tree.
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  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const wj=Ve("Link2",[["path",{d:"M9 17H7A5 5 0 0 1 7 7h2",key:"8i5ue5"}],["path",{d:"M15 7h2a5 5 0 1 1 0 10h-2",key:"1b9ql8"}],["line",{x1:"8",x2:"16",y1:"12",y2:"12",key:"1jonct"}]]);/**
+ */const Uw=$e("Link2",[["path",{d:"M9 17H7A5 5 0 0 1 7 7h2",key:"8i5ue5"}],["path",{d:"M15 7h2a5 5 0 1 1 0 10h-2",key:"1b9ql8"}],["line",{x1:"8",x2:"16",y1:"12",y2:"12",key:"1jonct"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const jj=Ve("Maximize2",[["polyline",{points:"15 3 21 3 21 9",key:"mznyad"}],["polyline",{points:"9 21 3 21 3 15",key:"1avn1i"}],["line",{x1:"21",x2:"14",y1:"3",y2:"10",key:"ota7mn"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
+ */const $w=$e("Maximize2",[["polyline",{points:"15 3 21 3 21 9",key:"mznyad"}],["polyline",{points:"9 21 3 21 3 15",key:"1avn1i"}],["line",{x1:"21",x2:"14",y1:"3",y2:"10",key:"ota7mn"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Cj=Ve("Microscope",[["path",{d:"M6 18h8",key:"1borvv"}],["path",{d:"M3 22h18",key:"8prr45"}],["path",{d:"M14 22a7 7 0 1 0 0-14h-1",key:"1jwaiy"}],["path",{d:"M9 14h2",key:"197e7h"}],["path",{d:"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z",key:"1bmzmy"}],["path",{d:"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3",key:"1drr47"}]]);/**
+ */const Vw=$e("Microscope",[["path",{d:"M6 18h8",key:"1borvv"}],["path",{d:"M3 22h18",key:"8prr45"}],["path",{d:"M14 22a7 7 0 1 0 0-14h-1",key:"1jwaiy"}],["path",{d:"M9 14h2",key:"197e7h"}],["path",{d:"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z",key:"1bmzmy"}],["path",{d:"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3",key:"1drr47"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Nj=Ve("Minimize2",[["polyline",{points:"4 14 10 14 10 20",key:"11kfnr"}],["polyline",{points:"20 10 14 10 14 4",key:"rlmsce"}],["line",{x1:"14",x2:"21",y1:"10",y2:"3",key:"o5lafz"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
+ */const Fw=$e("Minimize2",[["polyline",{points:"4 14 10 14 10 20",key:"11kfnr"}],["polyline",{points:"20 10 14 10 14 4",key:"rlmsce"}],["line",{x1:"14",x2:"21",y1:"10",y2:"3",key:"o5lafz"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Ej=Ve("PanelLeftClose",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m16 15-3-3 3-3",key:"14y99z"}]]);/**
+ */const kw=$e("PanelLeftClose",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m16 15-3-3 3-3",key:"14y99z"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Mj=Ve("PanelLeftOpen",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m14 9 3 3-3 3",key:"8010ee"}]]);/**
+ */const Bw=$e("PanelLeftOpen",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m14 9 3 3-3 3",key:"8010ee"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Bu=Ve("Search",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["path",{d:"m21 21-4.3-4.3",key:"1qie3q"}]]);/**
+ */const Wu=$e("Search",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["path",{d:"m21 21-4.3-4.3",key:"1qie3q"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const _j=Ve("Shield",[["path",{d:"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z",key:"oel41y"}]]);/**
+ */const Gw=$e("Shield",[["path",{d:"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z",key:"oel41y"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Rj=Ve("Shuffle",[["path",{d:"m18 14 4 4-4 4",key:"10pe0f"}],["path",{d:"m18 2 4 4-4 4",key:"pucp1d"}],["path",{d:"M2 18h1.973a4 4 0 0 0 3.3-1.7l5.454-8.6a4 4 0 0 1 3.3-1.7H22",key:"1ailkh"}],["path",{d:"M2 6h1.972a4 4 0 0 1 3.6 2.2",key:"km57vx"}],["path",{d:"M22 18h-6.041a4 4 0 0 1-3.3-1.8l-.359-.45",key:"os18l9"}]]);/**
+ */const qw=$e("Shuffle",[["path",{d:"m18 14 4 4-4 4",key:"10pe0f"}],["path",{d:"m18 2 4 4-4 4",key:"pucp1d"}],["path",{d:"M2 18h1.973a4 4 0 0 0 3.3-1.7l5.454-8.6a4 4 0 0 1 3.3-1.7H22",key:"1ailkh"}],["path",{d:"M2 6h1.972a4 4 0 0 1 3.6 2.2",key:"km57vx"}],["path",{d:"M22 18h-6.041a4 4 0 0 1-3.3-1.8l-.359-.45",key:"os18l9"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const kx=Ve("TriangleAlert",[["path",{d:"m21.73 18-8-14a2 2 0 0 0-3.48 0l-8 14A2 2 0 0 0 4 21h16a2 2 0 0 0 1.73-3",key:"wmoenq"}],["path",{d:"M12 9v4",key:"juzpu7"}],["path",{d:"M12 17h.01",key:"p32p05"}]]);/**
+ */const a1=$e("TriangleAlert",[["path",{d:"m21.73 18-8-14a2 2 0 0 0-3.48 0l-8 14A2 2 0 0 0 4 21h16a2 2 0 0 0 1.73-3",key:"wmoenq"}],["path",{d:"M12 9v4",key:"juzpu7"}],["path",{d:"M12 17h.01",key:"p32p05"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Tj=Ve("UserRound",[["circle",{cx:"12",cy:"8",r:"5",key:"1hypcn"}],["path",{d:"M20 21a8 8 0 0 0-16 0",key:"rfgkzh"}]]);/**
+ */const Qw=$e("UserRound",[["circle",{cx:"12",cy:"8",r:"5",key:"1hypcn"}],["path",{d:"M20 21a8 8 0 0 0-16 0",key:"rfgkzh"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Aj=Ve("Users",[["path",{d:"M16 21v-2a4 4 0 0 0-4-4H6a4 4 0 0 0-4 4v2",key:"1yyitq"}],["circle",{cx:"9",cy:"7",r:"4",key:"nufk8"}],["path",{d:"M22 21v-2a4 4 0 0 0-3-3.87",key:"kshegd"}],["path",{d:"M16 3.13a4 4 0 0 1 0 7.75",key:"1da9ce"}]]);/**
+ */const Yw=$e("Users",[["path",{d:"M16 21v-2a4 4 0 0 0-4-4H6a4 4 0 0 0-4 4v2",key:"1yyitq"}],["circle",{cx:"9",cy:"7",r:"4",key:"nufk8"}],["path",{d:"M22 21v-2a4 4 0 0 0-3-3.87",key:"kshegd"}],["path",{d:"M16 3.13a4 4 0 0 1 0 7.75",key:"1da9ce"}]]);/**
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  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Oj=Ve("Waves",[["path",{d:"M2 6c.6.5 1.2 1 2.5 1C7 7 7 5 9.5 5c2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"knzxuh"}],["path",{d:"M2 12c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"2jd2cc"}],["path",{d:"M2 18c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"rd2r6e"}]]);/**
+ */const Iw=$e("Waves",[["path",{d:"M2 6c.6.5 1.2 1 2.5 1C7 7 7 5 9.5 5c2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"knzxuh"}],["path",{d:"M2 12c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"2jd2cc"}],["path",{d:"M2 18c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"rd2r6e"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const Ju=Ve("X",[["path",{d:"M18 6 6 18",key:"1bl5f8"}],["path",{d:"m6 6 12 12",key:"d8bk6v"}]]);/**
+ */const cc=$e("X",[["path",{d:"M18 6 6 18",key:"1bl5f8"}],["path",{d:"m6 6 12 12",key:"d8bk6v"}]]);/**
  * @license lucide-react v0.468.0 - ISC
  *
  * This source code is licensed under the ISC license.
  * See the LICENSE file in the root directory of this source tree.
- */const zj=Ve("ZoomOut",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["line",{x1:"21",x2:"16.65",y1:"21",y2:"16.65",key:"13gj7c"}],["line",{x1:"8",x2:"14",y1:"11",y2:"11",key:"durymu"}]]);function Dj(n){if(n.value===null)return n.text??"";switch(n.key){case"coverage":return`${Math.round(n.value)}×`;case"tmb":return n.value<.01?n.value.toPrecision(2):n.value.toFixed(2);default:return n.value.toFixed(2)}}function Hj(n){return n.status==="failed"?"Failed":n.status==="skipped"?"Not in this mode":"Not run"}const Lj=new Intl.DateTimeFormat("en-GB",{day:"numeric",month:"short",year:"numeric"});function Gx(n){if(!n)return"";const s=new Date(n);return Number.isNaN(s.getTime())?"":Lj.format(s)}function hm(n,s){return n.startsWith(`${s}_`)?n.slice(s.length+1):n}function kh(n){return n==null?"–":n.toFixed(2)}const gy={missense_variant:"Missense",stop_gained:"Nonsense",stop_lost:"Stop lost",start_lost:"Start lost",frameshift_variant:"Frameshift",inframe_deletion:"In-frame 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f.jsxs("div",{className:"flex items-start gap-2.5 text-sm",style:{color:"var(--ink-2)"},children:[f.jsx(i,{size:18,"aria-hidden":!0,style:{color:s?"var(--warn-ink)":"var(--chev)",flex:"none"}}),f.jsxs("div",{className:"flex flex-col gap-1",children:[f.jsx("span",{className:"font-semibold",style:{color:"var(--ink)"},children:s?"This panel could not be read":"Nothing to show here"}),n.warnings.map(r=>f.jsx("span",{children:r},r))]})]})}const Yh={summary:{title:"Genome fingerprint and summary",intro:"A one-glance portrait of the selected tumour: its copy-number changes and driver mutations drawn as a ring, a sentence describing them, and the headline measurements of the sample.",sections:[{heading:"The fingerprint ring",paragraphs:["The ring is the whole genome. Chromosome 1 starts at the top and the ring runs clockwise through chromosome 22 to X, each chromosome's arc in proportion to its length (GRCh37).","Copy-number changes are called against the tumour's baseline, its ploidy rounded to whole copies. Very short changes are drawn at a minimum length so they stay visible."],terms:[["Gains (outer track, orange)","Regions with at least one copy more than the baseline."],["Amplifications (outer track, darker and thicker)","Regions with three or more copies above the baseline."],["Losses (inner track, blue)","Regions with at least one copy fewer than the baseline."],["Drivers (black ticks)","Where the tumour's likely driver mutations sit (see the Mutations card for how they are flagged)."]]},{heading:"The sentence",paragraphs:["Written from the same data as the ring: how many amplifications, gains and losses there are and on which chromosomes, and which genes carry driver mutations."]},{heading:"The measurements",paragraphs:["Each tile shows a value, a small picture of where it sits on its scale when it has a natural one, and the analysis it came from. A tile with no value says why: the analysis was not run, it failed, or it does not apply to this kind of report (tumour-only reports have no matched normal)."],terms:[["Purity","The estimated fraction of cells in the sample that are tumour cells, from 0 to 1. The ring fills to the value."],["Ploidy","The tumour's average number of copies across the genome. The scale runs from 1 to 6 copies; the tall tick marks 2, a diploid genome."],["Coverage","The median sequencing depth of the tumour across the genome, in reads (×)."],["TMB per Mb","Tumour mutational burden: somatic SNVs and indels per megabase of genome. The report computes it from the counts of the SNV and indel calls. The scale is logarithmic, 0.01 to 100."],["MSI score","The MSIsensor score: the percentage of microsatellite sites that look unstable in the tumour."],["FGA","Fraction of the genome altered: the share of the genome whose copy number differs from the baseline, from 0 to 1. It is read from the project-wide Battenberg tables."]]},{heading:"Linking back to the analyses",paragraphs:[`Every value names its analysis, with version and Isabl id. Picking an analysis in the side menu's "Analyses on this page" highlights the tiles and cards it feeds.`]}]},copyNumber:{title:"Copy number",intro:"How many copies of each part of the genome the tumour carries, segment by segment, from chromosome 1 to X.",sections:[{heading:"What is drawn",paragraphs:['Each horizontal stroke is one segment: a stretch of the genome with a constant copy number. Its height is the number of copies, from 0 up to 8; anything higher is drawn at the top and the axis reads "8+". A gain or amplification rises as a column from the baseline to its stroke, and a loss falls to it, so the changes read as a landscape. Alternating grey bands mark the chromosomes, named in a strip along the bottom.',`The line across the plot is the baseline: the tumour's ploidy rounded to whole copies (labelled, for example, "2 copies"). Segments are coloured by how they compare with it.`],terms:[["Grey","Neutral: the same number of copies as the baseline."],["Orange","Gain: at least one copy more than the baseline."],["Dark orange","Amplification: three or more copies above the baseline."],["Blue","Loss: at least one copy fewer than the baseline."]]},{heading:"Total or allele-specific",paragraphs:["Total shows all copies together. Allele-specific, when the analysis provides it, splits each segment into its major allele (the more common parental copy, dark) and minor allele (light). Where the two are equal they are drawn slightly apart so both stay visible. A minor allele of 0 means one parent's copy is lost there (loss of heterozygosity)."]},{heading:"Driver genes",paragraphs:["A label along the top names each gene with likely driver mutations, one per gene, joined by a line to a dot on the segment the gene sits on, so its copy number can be read off at once. Hover one for its protein changes and the copies there."]},{heading:"Reading and moving around",terms:[["Hover a segment","Its call, copies (major + minor), coordinates and, when available, log2 ratio. A readout at the foot of the plot gives the pointer's place on the genome."],["Click a segment","Lists the mutations inside it in the Mutations card."],["Click a driver","Finds that gene in the Mutations card."],["Pinch, or Ctrl and scroll","Zooms around the pointer. Plain scrolling always scrolls the page."],["Drag","Pans a zoomed view."],["Arrow keys, plus and minus, 0","With the plot focused: pan, zoom in and out, and show the whole genome."],["Double-click a chromosome, or click its name","Glides to fill the view with it; the strip then counts megabases."],["The overview","The whole genome in miniature under the strip. Its window shows where the plot is: drag the window to move, its ends to resize, or click elsewhere to centre it there. The button by the title returns to the whole genome."],["Hover a mutation in the table","Marks it here, with a ring on the segment it sits on and its copy number."]]},{heading:"Tumour-only reports",paragraphs:["Without a matched normal there is no ploidy estimate, so segments come from CNVkit and are called against two copies. Allele-specific copy numbers are not available."]}]},mutations:{title:"Mutations",intro:"The tumour's somatic SNVs and indels that passed the callers' filters: how they are distributed across cancer cells, and a searchable, filterable table of every call.",sections:[{heading:"Which mutations",terms:[["Drivers","Likely drivers flagged by the report: coding mutations that match OncoKB or COSMIC driver annotations (the exact protein change, or a damaging consequence in a known cancer gene), plus known hotspots the callers missed and the report recovered from the tumour's reads."],["Coding","Mutations whose effect changes a protein, by the report's list of coding effects."],["All","Every PASS SNV and indel."]],paragraphs:["The counts beside each choice follow the search and filters, so they always say what you would see."]},{heading:"FFPE samples",paragraphs:["Formalin-fixed (FFPE) tissue damages DNA in ways that look like mutations, mostly C>T changes at low allele fractions. For an FFPE sample, FFPERASE scores each SNV and indel for how likely it is to be such an artifact, and the report counts only the calls scored at or below its threshold (quoted beside the table). Its SNV, indel and coding totals and the TMB leave the rest out.",`The report marks each call it leaves out, and the dashboard follows that mark: the Coding and All counts, the table and the curve leave those calls out, and the card's subtitle says so. Drivers are all listed, as in the report, and any the filter would remove carry an "FFPE filtered" tag. "Show filtered calls", under FFPE filter beside the table, brings the removed calls back, tagged the same way.`]},{heading:"Cancer cell fraction and variant allele fraction",paragraphs:["The curve across the top is a smoothed histogram of every PASS mutation; driver mutations sit on it as labelled dots, and the diamond on the axis is the median. Switch between the two measures:"],terms:[["CCF",'Cancer cell fraction: the estimated share of cancer cells carrying the mutation, corrected for purity and copy number. Around 1 (the "clonal" mark) means nearly every cancer cell has it, which suggests it arose early; clearly below 1 means a subclone. Estimates can land somewhat above 1. Shown from 0 to 2.'],["VAF","Variant allele fraction: the share of sequencing reads at the position that carry the mutation, from 0 to 1. Raw, not corrected for purity or copy number. Tumour-only reports open on VAF, since CCF needs a matched normal."]]},{heading:"Filtering by the curve",paragraphs:["Drag across the curve to keep only mutations in that CCF or VAF range: the curve stays lit inside the range and fades outside it, and the range is read out at its foot. Drag the edges to resize it, or its body to move it. The range appears with the other filters and can be removed there, or by clicking the curve."]},{heading:"The table",terms:[["Gene and position","The gene, and the mutation's chromosome and position (GRCh37)."],["Change","The protein change, with the cDNA change beneath."],["Effect","What the mutation does to the gene, from the VEP consequence (or the report's effect). Truncating effects are in bold."],["VAF and CCF bars","The value with a bar for quick comparison; the CCF bar's tick marks 1, clonal."],["Driver","Flagged as a likely driver (shown when the table is not already limited to drivers)."],["Hotspot","The exact protein change is a known recurrent cancer hotspot."],["In DMP","The same mutation was also found by the patient's clinical MSK-IMPACT (DMP) sequencing."],["FFPE filtered","FFPE samples only: the report's FFPE artifact filter leaves this call out of its counts (see FFPE samples)."]]},{heading:"Opening a row",terms:[["Variant","SNV or indel, with the reference and alternate bases."],["Reads","Reads supporting the mutation out of all reads at the position. Only hotspots the report recovered from the tumour's reads have them; the callers' tables give no single count."],["Normal VAF","The mutation's allele fraction in the matched normal; near 0 for a somatic mutation."],["Mutant copies","How many copies of that part of the genome carry the mutation, out of all copies there."],["Consequence","The full VEP consequence."],["COSMIC","How many samples in COSMIC carry it, and how closely they match (exact change, same position, codon or gene)."],["Expression","The gene's expression in the tumour's RNA, in transcripts per million, when RNA was sequenced."],["Gene role","Whether the gene is a known oncogene or tumour suppressor gene (TSG)."],["Show on copy number","Zooms the Copy number card to the mutation's chromosome and marks it."]]},{heading:"Searching and filtering",paragraphs:["Search takes a gene, a protein or cDNA change, a COSMIC term, or a locus such as chr12:25,398,284 or a range such as chr8:1-50,000,000. Press / anywhere on the page to jump to it. Each filter's count is how many rows you would get by ticking it, given everything else."],terms:[["Missense","One amino acid replaced by another."],["Truncating","Stop gained or lost, start lost, or a frameshift."],["Splice","Changes a splice site or splice region."],["In-frame","Inserts or deletes amino acids without shifting the reading frame."],["Synonymous","Changes the DNA but not the amino acid."],["Other","Everything else, such as intronic, UTR or upstream changes."]]}]},structuralVariants:{title:"Structural variants",intro:"The tumour's rearrangements as the report shows them: those with a breakpoint in an oncogene or tumour suppressor, those that take in a whole gene, and how all of them group into rearrangement signatures.",sections:[{heading:"Which rearrangements",paragraphs:["The report works from the high-confidence structural variants of ANNOT_SVS, which keeps calls made by two or more callers (SvABA, BRASS and GRIDSS) and annotates the genes they touch with AnnotSV. The count beside the title is how many of these the report counts, its rearrangements total.",`The tables keep the rearrangements whose genes include an oncogene or tumour suppressor, by the report's gene lists. It also searches the callers' raw calls for known rearrangements the high-confidence set can miss, such as CIC fusions, and adds them; a rescued event that is not a two-caller PASS says so in its callers, as in "gridss (CIC rescued)".`]},{heading:"The two tables",terms:[["Rearranged oncogenes and tumour suppressors",'One row per rearrangement and gene it hits, with the gene and breakpoint on each side. A gene near a breakpoint rather than in it is named as the report names it, such as "TERT +/- 100Kb".'],["Whole-gene rearrangements","Rearrangements that take in a whole oncogene or tumour suppressor, from start to end: a deletion of the whole gene, for example."],["Role","Whether the row's genes include an oncogene, a tumour suppressor or both, as the report colours its rows. Click a role above the tables to show only its rows."],["Left and right","Each breakpoint's gene, position (GRCh37) and where it falls in the gene, as AnnotSV writes it (intron5, exon2-exon5). Breakpoints are ordered by chromosome, then position."],["Callers and support","The callers that made the call, and the most reads any of them gives in support."],["Pileups","Supporting reads over all reads at each breakpoint in the tumour's alignments, left then right."],["Expression","For tumours with RNA: whether each gene's expression is high or low against each expression cohort (p63 is cohort project 63): at or above its 90th percentile, at or below its 10th, or neither (None). N/A means the cohort has no value for the gene."]],paragraphs:["Open a row to see both breakpoints, show them on the copy-number card, or copy their IGV loci."]},{heading:"Rearrangement signatures",paragraphs:["WGSPOST groups the tumour's rearrangements the way rearrangement signatures are described: clustered (rearrangements that sit unusually close together, as in chromothripsis) or dispersed, then by class and, except for translocations, by size from under 1 kb to over 1 Mb. Each bar is how many rearrangements fall in a group, grouped under its class; lighter bars are the clustered ones, in the shaded zone. A group with none shows a short stub on the baseline. Hover a bar for its name and its share of all rearrangements, or a class in the key to light its bars.","WGSPOST counts from its own copy of the calls, so its total can differ slightly from the report's rearrangements count."],terms:[["Deletion","A stretch of the genome lost between two breakpoints."],["Tandem duplication","A stretch copied next to itself."],["Inversion","A stretch turned around in place."],["Translocation","A join between two chromosomes."]]}]},signaturesHrd:{title:"Signatures and HRD",intro:"Which mutational processes left their mark on the tumour, set against tumours of the same disease, and whether it shows homologous recombination deficiency (HRD), as the report shows them.",sections:[{heading:"Mutational signatures",paragraphs:["WGSPOST fits known COSMIC substitution signatures to the tumour's somatic SNVs and estimates how many mutations each one accounts for. The left column is this tumour: each band is a signature's share of its mutations, the largest first.","The right column is the average of tumours of the same disease in the cohort (n is how many), each tumour's shares averaged and scaled to the cohort's average mutation count. A ribbon joins each signature's two bands, widening or narrowing with its share, so a signature can be followed from the tumour to its cohort; a label on the ribbon says how many percentage points the tumour leads or trails the cohort by, where the difference is at least 5. Hover a band, a ribbon or a row of the table for the numbers.","Seven signatures get colours of their own (eight when there are no more than eight); any beyond that are drawn together as Other. A tumour without a cohort to compare shows its own shares as one column."],terms:[["Signature","A pattern of substitutions, by the base change and its neighbours, that a mutational process leaves (SBS1, SBS5)."],["Aetiology","The process the report links a signature to, when it names one."]]},{heading:"96 mutational contexts",paragraphs:["Every substitution is one of six kinds (C>A, C>G, C>T, T>A, T>C, T>G, naming the pyrimidine base of the pair) and sits between two neighbouring bases, which gives 96 contexts. The top panel counts the tumour's SNVs in each, as WGSPOST's MutationalPatterns step does. The middle panel is what the fitted signatures rebuild: each signature's probabilities for the 96 contexts, weighted by its contribution above and added up. The bottom panel is the first minus the second, so a bar above the line is a context with more SNVs than the signatures explain.","Share draws each profile as percentages of its own total, which is how the report's figure compares the two; Count draws SNVs. Both profiles share one scale, and the difference its own. Click a class in the header to open it and name its sixteen contexts, written as the base before, the mutated base in colour, and the base after. Hover a column to read all three panels at once.","Cosine similarity and RSS are the report's own measures of the fit: the closer to 1 (cosine) and to 0 (RSS), the better the signatures explain the tumour. They are computed by the report from the relative profiles, as MutationalPatterns does. For an FFPE sample, switch between the run the report uses (its FFPE-filtered calls) and the unfiltered one. When the report did not include the signature matrix its fit used, only the observed profile is drawn."]},{heading:"HRD scores",paragraphs:["Two classifiers estimate whether the tumour has lost homologous recombination repair, as BRCA1 or BRCA2 loss does: HRDetect, from the substitution, indel and rearrangement patterns below, and CHORD, from its own set of mutation features. The report rates each HIGH at or above its threshold and LOW below it; the line on each gauge is the threshold."]},{heading:"HRDetect features",paragraphs:["The six features HRDetect weighs, for every tumour in the cohort and this one, each scaled from 0 (the cohort's lowest) to 1 (its highest). Each row is one feature: the pin is this tumour, the dots beneath are the cohort's samples, the shaded band is the middle half of the cohort and the line in it the median. With eight or more cohort samples a smoothed outline of how the samples are spread is drawn above the dots; with fewer it is left out, because it would suggest more than the data says. The words at the right say how many of the other cohort samples the tumour is above. Hover a row for the unscaled value. For FFPE samples the tumour's values come from its FFPE-filtered analysis."],terms:[["Del. MH","The share of deletions with microhomology at their ends, a sign of repair by end joining."],["SBS3 and SBS8","Substitution signatures 3 and 8."],["RS3 and RS5","Rearrangement signatures 3 (small tandem duplications) and 5 (deletions)."],["HRD index","Loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions, combined."]]}]}},TC={summary:{BATTENBERG:"Tumour purity and ploidy, and the copy-number segments the ring's gains and losses are called from.","BATTENBERG cohort":"Project-wide Battenberg tables, which hold the FGA value and the cohort it is compared with.",CNV_UNMATCHED:"Copy-number segments of a tumour-only report (CNVkit), which the ring's gains and losses are called from.",MOSDEPTH:"The median sequencing coverage.",MSISENSOR:"The MSI score.",MSISENSOR_UNMATCHED:"The MSI score of a tumour-only report.",ANNOT_SNVS:"Somatic SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS:"Somatic indel calls: their count goes into TMB, and driver indels are marked on the ring.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls: their count goes into TMB, and driver indels are marked on the ring.",WGSPOST:"Cancer cell fractions of the mutations, read together with the driver calls marked on the ring."},copyNumber:{BATTENBERG:"Every segment drawn: total copies, major and minor allele copies, and the ploidy the baseline is rounded from.","BATTENBERG cohort":"Project-wide Battenberg tables the report reads alongside this run; they hold the FGA, and are not drawn here.",CNV_UNMATCHED:"The segments of a tumour-only report (CNVkit), drawn against two copies."},mutations:{ANNOT_SNVS:"The tumour's PASS somatic SNVs and their annotation: gene, protein and cDNA change, effect, VAF, read counts, normal VAF and COSMIC.",ANNOT_INDELS:"The tumour's PASS somatic indels and their annotation, as for SNVs.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls and their annotation.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls and their annotation.",WGSPOST:"Each mutation's cancer cell fraction (CCF) and how many copies carry it.",BATTENBERG:"Ploidy, which fills in the copy count where WGSPOST has none, and purity, which gives a CCF to hotspots recovered from the tumour's reads.",FFPERASE_SNVS:"FFPE samples: each SNV's artifact score. Calls scoring above the report's threshold are left out of the counts.",FFPERASE_INDELS:"FFPE samples: each indel's artifact score. Calls scoring above the report's threshold are left out of the counts."},structuralVariants:{ANNOT_SVS:"The high-confidence structural variants and their AnnotSV gene annotation: the rearrangements the report counts and the rows of its tables.",ANNOT_SVS_UNMATCHED:"Tumour-only structural variants and their annotation, kept when rare in the population.",SVABA:"Raw SvABA calls, searched for known rearrangements the high-confidence set missed (rescued events).",GRIDSS:"Raw GRIDSS calls, searched for rescued events like SvABA's.",SVABA_UNMATCHED:"Raw tumour-only SvABA calls, searched for rescued events.",GRIDSS_UNMATCHED:"Raw tumour-only GRIDSS calls, searched for rescued events.",WGSPOST:"The rearrangement-signature counts.",WGSPOST_UNMATCHED:"The rearrangement-signature counts of a tumour-only report."},signaturesHrd:{WGSPOST:"The tumour's signature contributions, its SNV counts in the 96 mutational contexts, its HRDetect and CHORD scores, and its HRDetect features.",WGSPOST_FFPE:"For an 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Chromosome 1 starts at the top and the ring runs clockwise through chromosome 22 to X, each chromosome's arc in proportion to its length (GRCh37).","Copy-number changes are called against the tumour's baseline, its ploidy rounded to whole copies. Very short changes are drawn at a minimum length so they stay visible."],terms:[["Gains (outer track, orange)","Regions with at least one copy more than the baseline."],["Amplifications (outer track, darker and thicker)","Regions with three or more copies above the baseline."],["Losses (inner track, blue)","Regions with at least one copy fewer than the baseline."],["Drivers (black ticks)","Where the tumour's likely driver mutations sit (see the Mutations card for how they are flagged)."]]},{heading:"The sentence",paragraphs:["Written from the same data as the ring: how many amplifications, gains and losses there are and on which chromosomes, and which genes carry driver mutations."]},{heading:"The measurements",paragraphs:["Each tile shows a value, a small picture of where it sits on its scale when it has a natural one, and the analysis it came from. A tile with no value says why: the analysis was not run, it failed, or it does not apply to this kind of report (tumour-only reports have no matched normal)."],terms:[["Purity","The estimated fraction of cells in the sample that are tumour cells, from 0 to 1. The ring fills to the value."],["Ploidy","The tumour's average number of copies across the genome. The scale runs from 1 to 6 copies; the tall tick marks 2, a diploid genome."],["Coverage","The median sequencing depth of the tumour across the genome, in reads (×)."],["TMB per Mb","Tumour mutational burden: somatic SNVs and indels per megabase of genome. The report computes it from the counts of the SNV and indel calls. The scale is logarithmic, 0.01 to 100."],["MSI score","The MSIsensor score: the percentage of microsatellite sites that look unstable in the tumour."],["FGA","Fraction of the genome altered: the share of the genome whose copy number differs from the baseline, from 0 to 1. It is read from the project-wide Battenberg tables."]]},{heading:"Linking back to the analyses",paragraphs:[`Every value names its analysis, with version and Isabl id. Picking an analysis in the side menu's "Analyses on this page" highlights the tiles and cards it feeds.`]}]},copyNumber:{title:"Copy number",intro:"How many copies of each part of the genome the tumour carries, segment by segment, from chromosome 1 to X.",sections:[{heading:"What is drawn",paragraphs:['Each horizontal stroke is one segment: a stretch of the genome with a constant copy number. Its height is the number of copies, from 0 up to 8; anything higher is drawn at the top and the axis reads "8+". A gain or amplification rises as a column from the baseline to its stroke, and a loss falls to it, so the changes read as a landscape. Alternating grey bands mark the chromosomes, named in a strip along the bottom.',`The line across the plot is the baseline: the tumour's ploidy rounded to whole copies (labelled, for example, "2 copies"). Segments are coloured by how they compare with it.`],terms:[["Grey","Neutral: the same number of copies as the baseline."],["Orange","Gain: at least one copy more than the baseline."],["Dark orange","Amplification: three or more copies above the baseline."],["Blue","Loss: at least one copy fewer than the baseline."]]},{heading:"Total or allele-specific",paragraphs:["Total shows all copies together. Allele-specific, when the analysis provides it, splits each segment into its major allele (the more common parental copy, dark) and minor allele (light). Where the two are equal they are drawn slightly apart so both stay visible. A minor allele of 0 means one parent's copy is lost there (loss of heterozygosity)."]},{heading:"Driver genes",paragraphs:["A label along the top names each gene with likely driver mutations, one per gene, joined by a line to a dot on the segment the gene sits on, so its copy number can be read off at once. Hover one for its protein changes and the copies there."]},{heading:"Amplified and lost genes",paragraphs:["The oncogenes the report calls amplified and the tumour suppressors it calls homozygously lost, from the copy number over each gene, in chromosome order. The row of cells shows the copy number (all eight filled means eight copies or more). When the sample has RNA, each gene also shows its expression against each expression cohort: the log2 of this sample's level over the cohort's mean, so +1 is twice the cohort's level. Point at a gene to mark it on the plot; click it to glide to its chromosome."]},{heading:"Fraction of genome altered against the cohort",paragraphs:["The tumour's FGA (the share of the genome whose copy number differs from the baseline) set against every tumour in the project's FGA table, by disease, as the report draws it: only diseases with at least five tumours, plus this tumour's own, highest median first, with some disease labels merged (OSOS and CHOS as OS, MFH as US, LIHB as HBL). Each box spans the middle half of a disease's tumours, the line in it is the median, the whiskers reach the furthest tumours within one and a half box-lengths, and each dot is one tumour. The pin is this tumour; hover a disease for its numbers and, in the tumour's own disease, where it ranks.","The cohort is the one the report compared with when it ran. It does not grow as the project does; rerun the report to compare with the cohort as it is now."]},{heading:"Reading and moving around",terms:[["Hover a segment","Its call, copies (major + minor), coordinates and, when available, log2 ratio. A readout at the foot of the plot gives the pointer's place on the genome."],["Click a segment","Lists the mutations inside it in the Mutations card."],["Click a driver","Finds that gene in the Mutations card."],["Pinch, or Ctrl and scroll","Zooms around the pointer. Plain scrolling always scrolls the page."],["Drag","Pans a zoomed view."],["Arrow keys, plus and minus, 0","With the plot focused: pan, zoom in and out, and show the whole genome."],["Double-click a chromosome, or click its name","Glides to fill the view with it; the strip then counts megabases."],["The overview","The whole genome in miniature under the strip. Its window shows where the plot is: drag the window to move, its ends to resize, or click elsewhere to centre it there. The button by the title returns to the whole genome."],["Hover a mutation in the table","Marks it here, with a ring on the segment it sits on and its copy number."]]},{heading:"Tumour-only reports",paragraphs:["Without a matched normal there is no ploidy estimate, so segments come from CNVkit and are called against two copies. Allele-specific copy numbers are not available."]}]},mutations:{title:"Mutations",intro:"The tumour's somatic SNVs and indels that passed the callers' filters: how they are distributed across cancer cells, and a searchable, filterable table of every call.",sections:[{heading:"Which mutations",terms:[["Drivers","Likely drivers flagged by the report: coding mutations that match OncoKB or COSMIC driver annotations (the exact protein change, or a damaging consequence in a known cancer gene), plus known hotspots the callers missed and the report recovered from the tumour's reads."],["Coding","Mutations whose effect changes a protein, by the report's list of coding effects."],["All","Every PASS SNV and indel."]],paragraphs:["The counts beside each choice follow the search and filters, so they always say what you would see."]},{heading:"FFPE samples",paragraphs:["Formalin-fixed (FFPE) tissue damages DNA in ways that look like mutations, mostly C>T changes at low allele fractions. For an FFPE sample, FFPERASE scores each SNV and indel for how likely it is to be such an artifact, and the report counts only the calls scored at or below its threshold (quoted beside the table). Its SNV, indel and coding totals and the TMB leave the rest out.",`The report marks each call it leaves out, and the dashboard follows that mark: the Coding and All counts, the table and the curve leave those calls out, and the card's subtitle says so. Drivers are all listed, as in the report, and any the filter would remove carry an "FFPE filtered" tag. "Show filtered calls", under FFPE filter beside the table, brings the removed calls back, tagged the same way.`]},{heading:"Cancer cell fraction and variant allele fraction",paragraphs:["The curve across the top is a smoothed histogram of every PASS mutation; driver mutations sit on it as labelled dots, and the diamond on the axis is the median. Switch between the two measures:"],terms:[["CCF",'Cancer cell fraction: the estimated share of cancer cells carrying the mutation, corrected for purity and copy number. Around 1 (the "clonal" mark) means nearly every cancer cell has it, which suggests it arose early; clearly below 1 means a subclone. Estimates can land somewhat above 1. Shown from 0 to 2.'],["VAF","Variant allele fraction: the share of sequencing reads at the position that carry the mutation, from 0 to 1. Raw, not corrected for purity or copy number. Tumour-only reports open on VAF, since CCF needs a matched normal."]]},{heading:"Filtering by the curve",paragraphs:["Drag across the curve to keep only mutations in that CCF or VAF range: the curve stays lit inside the range and fades outside it, and the range is read out at its foot. Drag the edges to resize it, or its body to move it. The range appears with the other filters and can be removed there, or by clicking the curve."]},{heading:"Coding mutations against reference cohorts",paragraphs:["At the foot of the card, the tumour's coding SNVs and indels set against reference tumours of the same disease, as the report's TMB figure draws them: Grobner and colleagues' published pan-cancer cohort, where the disease has a match there, and MSK's TMB reference project. Each cohort is a violin cut at its smallest and largest tumour; two cohorts share one violin, one on each side. The bar inside marks the middle half and the circle the median. The line across is this tumour; hover a cohort for its numbers and where the tumour ranks.","Counts are coding mutations as the report counts them (after the FFPE filter for FFPE samples), the same numbers as the Coding tab. The MSK cohort leaves out tumours far above its 99th percentile, as the report does. The cohorts are the ones the report compared with when it ran; rerun the report to compare with them as they are now."]},{heading:"The table",terms:[["Gene and position","The gene, and the mutation's chromosome and position (GRCh37)."],["Change","The protein change, with the cDNA change beneath."],["Effect","What the mutation does to the gene, from the VEP consequence (or the report's effect). Truncating effects are in bold."],["VAF and CCF bars","The value with a bar for quick comparison; the CCF bar's tick marks 1, clonal."],["Driver","Flagged as a likely driver (shown when the table is not already limited to drivers)."],["Hotspot","The exact protein change is a known recurrent cancer hotspot."],["In DMP","The same mutation was also found by the patient's clinical MSK-IMPACT (DMP) sequencing."],["FFPE filtered","FFPE samples only: the report's FFPE artifact filter leaves this call out of its counts (see FFPE samples)."]]},{heading:"Opening a row",terms:[["Variant","SNV or indel, with the reference and alternate bases."],["Reads","Reads supporting the mutation out of all reads at the position. Only hotspots the report recovered from the tumour's reads have them; the callers' tables give no single count."],["Normal VAF","The mutation's allele fraction in the matched normal; near 0 for a somatic mutation."],["Mutant copies","How many copies of that part of the genome carry the mutation, out of all copies there."],["Consequence","The full VEP consequence."],["COSMIC","How many samples in COSMIC carry it, and how closely they match (exact change, same position, codon or gene)."],["Expression","The gene's expression in the tumour's RNA, in transcripts per million, when RNA was sequenced."],["Gene role","Whether the gene is a known oncogene or tumour suppressor gene (TSG)."],["Show on copy number","Zooms the Copy number card to the mutation's chromosome and marks it."]]},{heading:"Searching and filtering",paragraphs:["Search takes a gene, a protein or cDNA change, a COSMIC term, or a locus such as chr12:25,398,284 or a range such as chr8:1-50,000,000. Press / anywhere on the page to jump to it. Each filter's count is how many rows you would get by ticking it, given everything else."],terms:[["Missense","One amino acid replaced by another."],["Truncating","Stop gained or lost, start lost, or a frameshift."],["Splice","Changes a splice site or splice region."],["In-frame","Inserts or deletes amino acids without shifting the reading frame."],["Synonymous","Changes the DNA but not the amino acid."],["Other","Everything else, such as intronic, UTR or upstream changes."]]}]},structuralVariants:{title:"Structural variants",intro:"The tumour's rearrangements as the report shows them: those with a breakpoint in an oncogene or tumour suppressor, those that take in a whole gene, and how all of them group into rearrangement signatures.",sections:[{heading:"Which rearrangements",paragraphs:["The report works from the high-confidence structural variants of ANNOT_SVS, which keeps calls made by two or more callers (SvABA, BRASS and GRIDSS) and annotates the genes they touch with AnnotSV. The count beside the title is how many of these the report counts, its rearrangements total.",`The tables keep the rearrangements whose genes include an oncogene or tumour suppressor, by the report's gene lists. It also searches the callers' raw calls for known rearrangements the high-confidence set can miss, such as CIC fusions, and adds them; a rescued event that is not a two-caller PASS says so in its callers, as in "gridss (CIC rescued)".`]},{heading:"The two tables",terms:[["Rearranged oncogenes and tumour suppressors",'One row per rearrangement and gene it hits, with the gene and breakpoint on each side. A gene near a breakpoint rather than in it is named as the report names it, such as "TERT +/- 100Kb".'],["Whole-gene rearrangements","Rearrangements that take in a whole oncogene or tumour suppressor, from start to end: a deletion of the whole gene, for example."],["Role","Whether the row's genes include an oncogene, a tumour suppressor or both, as the report colours its rows. Click a role above the tables to show only its rows."],["Left and right","Each breakpoint's gene, position (GRCh37) and where it falls in the gene, as AnnotSV writes it (intron5, exon2-exon5). Breakpoints are ordered by chromosome, then position."],["Callers and support","The callers that made the call, and the most reads any of them gives in support."],["Pileups","Supporting reads over all reads at each breakpoint in the tumour's alignments, left then right."],["Expression","For tumours with RNA: whether each gene's expression is high or low against each expression cohort (p63 is cohort project 63): at or above its 90th percentile, at or below its 10th, or neither (None). N/A means the cohort has no value for the gene."]],paragraphs:["Open a row to see both breakpoints, show them on the copy-number card, or copy their IGV loci."]},{heading:"Rearrangement signatures",paragraphs:["WGSPOST groups the tumour's rearrangements the way rearrangement signatures are described: clustered (rearrangements that sit unusually close together, as in chromothripsis) or dispersed, then by class and, except for translocations, by size from under 1 kb to over 1 Mb. Each bar is how many rearrangements fall in a group, grouped under its class; lighter bars are the clustered ones, in the shaded zone. A group with none shows a short stub on the baseline. Hover a bar for its name and its share of all rearrangements, or a class in the key to light its bars.","WGSPOST counts from its own copy of the calls, so its total can differ slightly from the report's rearrangements count."],terms:[["Deletion","A stretch of the genome lost between two breakpoints."],["Tandem duplication","A stretch copied next to itself."],["Inversion","A stretch turned around in place."],["Translocation","A join between two chromosomes."]]}]},signaturesHrd:{title:"Signatures and HRD",intro:"Which mutational processes left their mark on the tumour, set against tumours of the same disease, and whether it shows homologous recombination deficiency (HRD), as the report shows them.",sections:[{heading:"Mutational signatures",paragraphs:["WGSPOST fits known COSMIC substitution signatures to the tumour's somatic SNVs and estimates how many mutations each one accounts for. The left column is this tumour: each band is a signature's share of its mutations, the largest first.","The right column is the average of tumours of the same disease in the cohort (n is how many), each tumour's shares averaged and scaled to the cohort's average mutation count. A ribbon joins each signature's two bands, widening or narrowing with its share, so a signature can be followed from the tumour to its cohort; a label on the ribbon says how many percentage points the tumour leads or trails the cohort by, where the difference is at least 5. Hover a band, a ribbon or a row of the table for the numbers.","Seven signatures get colours of their own (eight when there are no more than eight); any beyond that are drawn together as Other. A tumour without a cohort to compare shows its own shares as one column."],terms:[["Signature","A pattern of substitutions, by the base change and its neighbours, that a mutational process leaves (SBS1, SBS5)."],["Aetiology","The process the report links a signature to, when it names one."]]},{heading:"96 mutational contexts",paragraphs:["Every substitution is one of six kinds (C>A, C>G, C>T, T>A, T>C, T>G, naming the pyrimidine base of the pair) and sits between two neighbouring bases, which gives 96 contexts. The top panel counts the tumour's SNVs in each, as WGSPOST's MutationalPatterns step does. The middle panel is what the fitted signatures rebuild: each signature's probabilities for the 96 contexts, weighted by its contribution above and added up. The bottom panel is the first minus the second, so a bar above the line is a context with more SNVs than the signatures explain.","Share draws each profile as percentages of its own total, which is how the report's figure compares the two; Count draws SNVs. Both profiles share one scale, and the difference its own. Click a class in the header to open it and name its sixteen contexts, written as the base before, the mutated base in colour, and the base after. Hover a column to read all three panels at once.","Cosine similarity and RSS are the report's own measures of the fit: the closer to 1 (cosine) and to 0 (RSS), the better the signatures explain the tumour. They are computed by the report from the relative profiles, as MutationalPatterns does. For an FFPE sample, switch between the run the report uses (its FFPE-filtered calls) and the unfiltered one. When the report did not include the signature matrix its fit used, only the observed profile is drawn."]},{heading:"HRD scores",paragraphs:["Two classifiers estimate whether the tumour has lost homologous recombination repair, as BRCA1 or BRCA2 loss does: HRDetect, from the substitution, indel and rearrangement patterns below, and CHORD, from its own set of mutation features. The report rates each HIGH at or above its threshold and LOW below it; the line on each gauge is the threshold."]},{heading:"HRDetect features",paragraphs:["The six features HRDetect weighs, for every tumour in the cohort and this one, each scaled from 0 (the cohort's lowest) to 1 (its highest). Each row is one feature: the pin is this tumour, the dots beneath are the cohort's samples, the shaded band is the middle half of the cohort and the line in it the median. With eight or more cohort samples a smoothed outline of how the samples are spread is drawn above the dots; with fewer it is left out, because it would suggest more than the data says. The words at the right say how many of the other cohort samples the tumour is above. Hover a row for the unscaled value. For FFPE samples the tumour's values come from its FFPE-filtered analysis."],terms:[["Del. MH","The share of deletions with microhomology at their ends, a sign of repair by end joining."],["SBS3 and SBS8","Substitution signatures 3 and 8."],["RS3 and RS5","Rearrangement signatures 3 (small tandem duplications) and 5 (deletions)."],["HRD index","Loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions, combined."]]}]}},IN={summary:{BATTENBERG:"Tumour purity and ploidy, and the copy-number segments the ring's gains and losses are called from.","BATTENBERG cohort":"Project-wide Battenberg tables, which hold the FGA value and the cohort it is compared with.",CNV_UNMATCHED:"Copy-number segments of a tumour-only report (CNVkit), which the ring's gains and losses are called from.",MOSDEPTH:"The median sequencing coverage.",MSISENSOR:"The MSI score.",MSISENSOR_UNMATCHED:"The MSI score of a tumour-only report.",ANNOT_SNVS:"Somatic SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS:"Somatic indel calls: their count goes into TMB, and driver indels are marked on the ring.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls: their count goes into TMB, and driver indels are marked on the ring.",WGSPOST:"Cancer cell fractions of the mutations, read together with the driver calls marked on the ring."},copyNumber:{BATTENBERG:"Every segment drawn: total copies, major and minor allele copies, and the ploidy the baseline is rounded from.","BATTENBERG cohort":"Project-wide Battenberg tables of FGA: the tumour's own FGA, and the cohort the FGA figure compares it with, as it was when the report ran.",CNV_UNMATCHED:"The segments of a tumour-only report (CNVkit), drawn against two copies."},mutations:{ANNOT_SNVS:"The tumour's PASS somatic SNVs and their annotation: gene, protein and cDNA change, effect, VAF, read counts, normal VAF and COSMIC.","ANNOT_SNVS cohort":"The TMB reference project's coding SNVs: MSK's reference tumours for the disease, counted for the TMB figure, as they were when the report ran.","ANNOT_INDELS cohort":"The TMB reference project's coding indels, counted for the TMB figure like its SNVs.",ANNOT_INDELS:"The tumour's PASS somatic indels and their annotation, as for SNVs.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls and their annotation.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls and their annotation.",WGSPOST:"Each mutation's cancer cell fraction (CCF) and how many copies carry it.",BATTENBERG:"Ploidy, which fills in the copy count where WGSPOST has none, and purity, which gives a CCF to hotspots recovered from the tumour's reads.",FFPERASE_SNVS:"FFPE samples: each SNV's artifact score. Calls scoring above the report's threshold are left out of the counts.",FFPERASE_INDELS:"FFPE samples: each indel's artifact score. Calls scoring above the report's threshold are left out of the counts."},structuralVariants:{ANNOT_SVS:"The high-confidence structural variants and their AnnotSV gene annotation: the rearrangements the report counts and the rows of its tables.",ANNOT_SVS_UNMATCHED:"Tumour-only structural variants and their annotation, kept when rare in the population.",SVABA:"Raw SvABA calls, searched for known rearrangements the high-confidence set missed (rescued events).",GRIDSS:"Raw GRIDSS calls, searched for rescued events like SvABA's.",SVABA_UNMATCHED:"Raw tumour-only SvABA calls, searched for rescued events.",GRIDSS_UNMATCHED:"Raw tumour-only GRIDSS calls, searched for rescued events.",WGSPOST:"The rearrangement-signature counts.",WGSPOST_UNMATCHED:"The rearrangement-signature counts of a tumour-only report."},signaturesHrd:{WGSPOST:"The tumour's signature contributions, its SNV counts in the 96 mutational contexts, its HRDetect and CHORD scores, and its HRDetect features.",WGSPOST_FFPE:"For an 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@@ -285,4 +285,4 @@ Error generating stack: `+a.message+`
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u={debug:!1,initialOffset:0,overscan:1,paddingStart:0,paddingEnd:0,scrollPaddingStart:0,scrollPaddingEnd:0,horizontal:!1,getItemKey:vE,rangeExtractor:yE,onChange:()=>{},measureElement:jE,initialRect:{width:0,height:0},scrollMargin:0,gap:0,indexAttribute:"data-index",initialMeasurementsCache:[],lanes:1,anchorTo:"start",followOnAppend:!1,scrollEndThreshold:1,isScrollingResetDelay:150,enabled:!0,isRtl:!1,useScrollendEvent:!1,useAnimationFrameWithResizeObserver:!1,laneAssignmentMode:"estimate",useCachedMeasurements:!1};for(const v in i){const b=i[v];b!==void 0&&(u[v]=b)}const d=this.options;let h=null,m=null,p=!1;if(d!==void 0&&d.enabled&&u.enabled&&u.anchorTo==="end"&&this.scrollElement!==null){const v=d.count,b=u.count,w=this.getMeasurements(),j=((r=this._singleLaneMeasurements)==null?void 0:r.items)??w,N=T=>mE(j[T]),M=v>0?N(0):null,R=v>0?N(v-1):null;if(b!==v||v>0&&b>0&&(u.getItemKey(0)!==M||u.getItemKey(b-1)!==R)){p=!0;const T=v>0?this.getVirtualItemForOffset(this.getScrollOffset())??w[0]:null;T&&(h=[T.key,this.getScrollOffset()-T.start]);const H=u.followOnAppend===!0?"auto":u.followOnAppend||null;H&&b>0&&this.isAtEnd(d.scrollEndThreshold)&&(v===0||u.getItemKey(b-1)!==R)&&(b>v||EE(v,b,N,u.getItemKey))&&(m=H)}}this.options=u,p&&(this.pendingMin=0,this.itemSizeCacheVersion++);let y=!1,x=0;if(h&&this.scrollOffset!==null){const[v,b]=h,w=this.getMeasurements(),{count:j,getItemKey:N}=this.options;let M=0;for(;M<j&&N(M)!==v;)M++;if(M<j){const R=w[M];if(R){const E=Math.max(0,R.start+b);!m&&E!==this.scrollOffset&&(x=E-this.scrollOffset,this.scrollOffset=E,y=!0)}}}(y||m)&&(this.pendingScrollAnchor=[y?h[0]:null,y?h[1]:0,m,x])},this.notify=i=>{var r,u;(u=(r=this.options).onChange)==null||u.call(r,this,i)},this.maybeNotify=ii(()=>(this.calculateRange(),[this.isScrolling,this.range?this.range.startIndex:null,this.range?this.range.endIndex:null]),i=>{this.notify(i)},{key:!1,debug:()=>this.options.debug,initialDeps:[this.isScrolling,this.range?this.range.startIndex:null,this.range?this.range.endIndex:null]}),this.cleanup=()=>{this.unsubs.filter(Boolean).forEach(i=>i()),this.unsubs=[],this.observer.disconnect(),this.rafId!=null&&this.targetWindow&&(this.targetWindow.cancelAnimationFrame(this.rafId),this.rafId=null),this.scrollState=null,this.isScrolling=!1,this.scrollDirection=null,this._iosDeferredAdjustment=0,this._iosTouching=!1,this._iosJustTouchEnded=!1,this._clampedAdjustment=null,this.scrollElement=null,this.targetWindow=null},this._didMount=()=>()=>{this.cleanup()},this._willUpdate=()=>{var i,r;const u=this.options.enabled?this.options.getScrollElement():null;if(this.scrollElement!==u){if(this.cleanup(),!u){this.maybeNotify();return}if(this.scrollElement=u,this.scrollElement&&"ownerDocument"in this.scrollElement?this.targetWindow=this.scrollElement.ownerDocument.defaultView:this.targetWindow=((i=this.scrollElement)==null?void 0:i.window)??null,this.elementsCache.forEach(h=>{this.observer.observe(h)}),this.unsubs.push(this.options.observeElementRect(this,h=>{this.scrollRect=h,this.maybeNotify()})),this.unsubs.push(this.options.observeElementOffset(this,(h,m)=>{if(m&&this._intendedScrollOffset===null&&h===this.scrollOffset)return;this._intendedScrollOffset!==null&&Math.abs(h-this._intendedScrollOffset)<1.5&&(h=this._intendedScrollOffset),this._intendedScrollOffset=null,this._clampedAdjustment!==null&&Math.abs(h-this._clampedAdjustment.maxAtWrite)>=1.5&&(this._clampedAdjustment=null),this.scrollAdjustments=0;const p=this.getScrollOffset();this.scrollDirection=m?p===h?this.scrollDirection:p<h?"forward":"backward":null,this.scrollOffset=h,this.isScrolling=m,this._flushIosDeferredIfReady(),this.scrollState&&this.scheduleScrollReconcile(),this.maybeNotify()})),"addEventListener"in this.scrollElement){const h=this.scrollElement,m=()=>{this._iosTouching=!0,this._iosJustTouchEnded=!1,this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)},p=()=>{this._iosTouching=!1,!(!ch()||this.targetWindow==null)&&(this._iosJustTouchEnded=!0,this._iosTouchEndTimerId=this.targetWindow.setTimeout(()=>{this._iosJustTouchEnded=!1,this._iosTouchEndTimerId=null,this._flushIosDeferredIfReady()},150))};h.addEventListener("touchstart",m,Iu),h.addEventListener("touchend",p,Iu),this.unsubs.push(()=>{h.removeEventListener("touchstart",m),h.removeEventListener("touchend",p),this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)})}this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})}const d=this.pendingScrollAnchor;if(this.pendingScrollAnchor=null,d&&this.scrollElement&&this.options.enabled){const[h,m,p,y]=d;h!==null&&!p&&(ch()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded)?y!==0&&(this._iosDeferredAdjustment+=y):((r=this.scrollState)==null?void 0:r.behavior)==="smooth"&&!Dy(this.getScrollOffset()-y,this.scrollState.lastTargetOffset)||this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})),p&&this.scrollToEnd({behavior:p})}this._retryClampedAdjustment()},this._retryClampedAdjustment=()=>{if(this._clampedAdjustment===null||!this.scrollElement||!this.options.enabled)return;const{target:i,maxAtWrite:r}=this._clampedAdjustment,u=this.getMaxScrollOffset();u>r+.5&&(this._clampedAdjustment=i>u+.5?{target:i,maxAtWrite:u}:null,this._scrollToOffset(i,{adjustments:void 0,behavior:void 0}))},this._flushIosDeferredIfReady=()=>{if(this._iosDeferredAdjustment===0||this.isScrolling||this._iosTouching||this._iosJustTouchEnded)return;const i=this.getScrollOffset(),r=this.getMaxScrollOffset();if(i<0||i>r)return;if(this._iosDeferredAdjustment<0&&i>=r-1){this._iosDeferredAdjustment=0;return}const u=this._iosDeferredAdjustment;this._iosDeferredAdjustment=0,this._scrollToOffset(i,{adjustments:this.scrollAdjustments+=u,behavior:void 0})},this.rafId=null,this.getSize=()=>this.options.enabled?(this.scrollRect=this.scrollRect??this.options.initialRect,this.scrollRect[this.options.horizontal?"width":"height"]):(this.scrollRect=null,0),this.getScrollOffset=()=>this.options.enabled?(this.scrollOffset=this.scrollOffset??(typeof this.options.initialOffset=="function"?this.options.initialOffset():this.options.initialOffset),this.scrollOffset):(this.scrollOffset=null,0),this.getMeasurementOptions=ii(()=>[this.options.count,this.options.paddingStart,this.options.scrollMargin,this.options.getItemKey,this.options.enabled,this.options.lanes,this.options.laneAssignmentMode,this.options.gap],(i,r,u,d,h,m,p,y)=>(this.prevLanes!==void 0&&this.prevLanes!==m&&(this.lanesChangedFlag=!0),this.prevLanes=m,this.pendingMin=null,{count:i,paddingStart:r,scrollMargin:u,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:p,gap:y}),{key:!1}),this.isIndexInRange=i=>i>=0&&i<this.options.count,this.getMeasurements=ii(()=>[this.getMeasurementOptions(),this.itemSizeCacheVersion],({count:i,paddingStart:r,scrollMargin:u,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:p,gap:y},x)=>{var v;const b=this.itemSizeCache;if(!h)return this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),[];if(this.laneAssignments.size>i)for(const E of this.laneAssignments.keys())E>=i&&this.laneAssignments.delete(E);this.lanesChangedFlag&&(this.lanesChangedFlag=!1,this.lanesSettling=!0,this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.pendingMin=null),this.measurementsCache.length===0&&!this.lanesSettling&&(this.measurementsCache=this.options.initialMeasurementsCache,this.measurementsCache.forEach(E=>{this.itemSizeCache.set(E.key,E.size)}));const w=this.lanesSettling?0:this.pendingMin??0;if(this.pendingMin=null,this.lanesSettling&&this.measurementsCache.length===i&&(this.lanesSettling=!1),m===1){const E=i*2;let U=(v=this._singleLaneMeasurements)==null?void 0:v.flat;if(!U||U.length<E){const O=new Float64Array(E);U&&w>0&&O.set(U.subarray(0,w*2)),U=O}const T=w===0?new Array(i):this._singleLaneMeasurements.items.slice();let H;if(w===0)H=r+u;else{const O=w-1;H=U[O*2]+U[O*2+1]+y}for(let O=w;O<i;O++){const I=d(O);T[O]=I;const ee=b.get(I),k=typeof ee=="number"?ee:this.options.estimateSize(O);U[O*2]=H,U[O*2+1]=k,H+=k+y}this._singleLaneMeasurements={flat:U,items:T};const D=gE(T,U);return this.measurementsCache=D,D}const j=this.measurementsCache.slice(0,w),N=new Array(m).fill(void 0),M=new Float64Array(m);let R=0;for(let E=0;E<w;E++){const U=j[E];U&&(N[U.lane]===void 0&&R++,N[U.lane]=E,M[U.lane]=U.end)}for(let E=w;E<i;E++){const U=d(E),T=this.laneAssignments.get(E);let H,D;const O=p==="estimate"||b.has(U);if(T!==void 0&&this.options.lanes>1){H=T;const ne=N[H],oe=ne!==void 0?j[ne]:void 0;D=oe?oe.end+y:r+u}else if(R===m){let ne=0,oe=M[0],ie=N[0];for(let Y=1;Y<m;Y++){const W=M[Y];(W<oe||W===oe&&N[Y]<ie)&&(ne=Y,oe=W,ie=N[Y])}H=ne,D=oe+y,O&&this.laneAssignments.set(E,H)}else H=E%this.options.lanes,D=r+u,O&&this.laneAssignments.set(E,H);const I=b.get(U),ee=typeof I=="number"?I:this.options.estimateSize(E),k=D+ee;j[E]={index:E,start:D,size:ee,end:k,key:U,lane:H},N[H]===void 0&&R++,N[H]=E,M[H]=k}return this.measurementsCache=j,j},{key:!1,debug:()=>this.options.debug}),this.calculateRange=ii(()=>[this.getMeasurements(),this.getSize(),this.getScrollOffset(),this.options.lanes],(i,r,u,d)=>i.length===0||r===0?(this.range=null,null):(this.range=RE(i,r,u,d,d===1&&this._singleLaneMeasurements!==null?this._singleLaneMeasurements.flat:null),this.range),{key:!1,debug:()=>this.options.debug}),this.getVirtualIndexes=ii(()=>{let i=null,r=null;const u=this.calculateRange();return u&&(i=u.startIndex,r=u.endIndex),this.maybeNotify.updateDeps([this.isScrolling,i,r]),[this.options.rangeExtractor,this.options.overscan,this.options.count,i,r]},(i,r,u,d,h)=>d===null||h===null?[]:i({startIndex:d,endIndex:h,overscan:r,count:u}),{key:!1,debug:()=>this.options.debug}),this.indexFromElement=i=>{const r=this.options.indexAttribute,u=i.getAttribute(r);return u?parseInt(u,10):(console.warn(`Missing attribute name '${r}={index}' on measured element.`),-1)},this.shouldMeasureDuringScroll=i=>{var r;if(!this.scrollState||this.scrollState.behavior!=="smooth")return!0;const u=this.scrollState.index??((r=this.getVirtualItemForOffset(this.scrollState.lastTargetOffset))==null?void 0:r.index);if(u!==void 0&&this.range){const d=Math.max(this.options.overscan,Math.ceil((this.range.endIndex-this.range.startIndex)/2)),h=Math.max(0,u-d),m=Math.min(this.options.count-1,u+d);return i>=h&&i<=m}return!0},this.measureElement=i=>{if(!i){this.elementsCache.forEach((h,m)=>{h.isConnected||(this.observer.unobserve(h),this.elementsCache.delete(m))});return}const r=this.indexFromElement(i);if(!this.isIndexInRange(r))return;const u=this.options.getItemKey(r),d=this.elementsCache.get(u);d!==i&&(d&&this.observer.unobserve(d),this.observer.observe(i),this.elementsCache.set(u,i)),(!this.isScrolling||this.scrollState)&&this.shouldMeasureDuringScroll(r)&&this.resizeItem(r,this.options.measureElement(i,void 0,this))},this.resizeItem=(i,r)=>{var u,d,h;if(!this.isIndexInRange(i))return;let m,p,y;const x=(u=this._singleLaneMeasurements)==null?void 0:u.flat;if(this.options.lanes===1&&x!=null)y=this.options.getItemKey(i),p=x[i*2],m=x[i*2+1];else{const w=this.measurementsCache[i];if(!w)return;y=w.key,p=w.start,m=w.size}const v=this.itemSizeCache.get(y)??m,b=r-v;if(b!==0){const w=this.options.anchorTo==="end"&&((d=this.scrollState)==null?void 0:d.behavior)!=="smooth"&&this.getVirtualDistanceFromEnd()<=this.options.scrollEndThreshold,j=w?this.getTotalSize():0,N=this.getScrollOffset()+this.scrollAdjustments,R=!this.itemSizeCache.has(y)?p<N:p+v<=N&&this.scrollDirection!=="backward",E=((h=this.scrollState)==null?void 0:h.behavior)!=="smooth"&&(this.shouldAdjustScrollPositionOnItemSizeChange!==void 0?this.shouldAdjustScrollPositionOnItemSizeChange(this.measurementsCache[i]??{index:i,key:y,start:p,size:m,end:p+m,lane:0},b,this):R);(this.pendingMin===null||i<this.pendingMin)&&(this.pendingMin=i),this.itemSizeCache.set(y,r),this.itemSizeCacheVersion++;let U=!1;w?U=this.applyScrollAdjustment(this.getTotalSize()-j):E&&(U=this.applyScrollAdjustment(b)),this.notify(U),this._retryClampedAdjustment()}},this.getVirtualItems=ii(()=>[this.getVirtualIndexes(),this.getMeasurements()],(i,r)=>{const u=[];for(let d=0,h=i.length;d<h;d++){const m=i[d],p=r[m];u.push(p)}return u},{key:!1,debug:()=>this.options.debug}),this.getVirtualItemForOffset=i=>{var r;const u=this.getMeasurements();if(u.length===0)return;const d=(r=this._singleLaneMeasurements)==null?void 0:r.flat,h=this.options.lanes===1&&d!=null,m=S1(0,u.length-1,h?p=>d[p*2]:p=>zy(u[p]).start,i);return zy(u[m])},this.getMaxScrollOffset=()=>{if(!this.scrollElement)return 0;if("scrollHeight"in this.scrollElement)return this.options.horizontal?this.scrollElement.scrollWidth-this.scrollElement.clientWidth:this.scrollElement.scrollHeight-this.scrollElement.clientHeight;{const i=this.scrollElement.document.documentElement;return this.options.horizontal?i.scrollWidth-this.scrollElement.innerWidth:i.scrollHeight-this.scrollElement.innerHeight}},this.getVirtualDistanceFromEnd=()=>Math.max(this.getTotalSize()-this.getSize()-this.getScrollOffset(),0),this.getDistanceFromEnd=()=>Math.max(this.getMaxScrollOffset()-this.getScrollOffset(),0),this.isAtEnd=(i=this.options.scrollEndThreshold)=>this.getDistanceFromEnd()<=i,this.getOffsetForAlignment=(i,r,u=0)=>{if(!this.scrollElement)return 0;const d=this.getSize(),h=this.getScrollOffset();r==="auto"&&(r=i>=h+d?"end":"start"),r==="center"?i+=(u-d)/2:r==="end"&&(i-=d);const m=this.getMaxScrollOffset();return Math.max(Math.min(m,i),0)},this.getOffsetForIndex=(i,r="auto")=>{i=Math.max(0,Math.min(i,this.options.count-1));const u=this.getSize(),d=this.getScrollOffset(),h=this.measurementsCache[i];if(!h)return;if(r==="auto")if(h.end>=d+u-this.options.scrollPaddingEnd)r="end";else if(h.start<=d+this.options.scrollPaddingStart)r="start";else return[d,r];if(r==="end"&&i===this.options.count-1)return[this.getMaxScrollOffset(),r];const m=r==="end"?h.end+this.options.scrollPaddingEnd:h.start-this.options.scrollPaddingStart;return[this.getOffsetForAlignment(m,r,h.size),r]},this.scrollToOffset=(i,{align:r="start",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0;const d=this.getOffsetForAlignment(i,r),h=this.now();this.scrollState={index:null,align:r,behavior:u,startedAt:h,lastTargetOffset:d,stableFrames:0},this._scrollToOffset(d,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollToIndex=(i,{align:r="auto",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0,i=Math.max(0,Math.min(i,this.options.count-1));const d=this.getOffsetForIndex(i,r);if(!d)return;const[h,m]=d,p=this.now();this.scrollState={index:i,align:m,behavior:u,startedAt:p,lastTargetOffset:h,stableFrames:0},this._scrollToOffset(h,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollBy=(i,{behavior:r="auto"}={})=>{const u=this.getScrollOffset()+i,d=this.now();this.scrollState={index:null,align:"start",behavior:r,startedAt:d,lastTargetOffset:u,stableFrames:0},this._scrollToOffset(u,{adjustments:void 0,behavior:r}),this.scheduleScrollReconcile()},this.scrollToEnd=({behavior:i="auto"}={})=>{if(this.options.count>0){this.scrollToIndex(this.options.count-1,{align:"end",behavior:i});return}this.scrollToOffset(Math.max(this.getTotalSize()-this.getSize(),0),{behavior:i})},this.getTotalSize=()=>{var i,r;const u=this.getMeasurements();let d;if(u.length===0)d=this.options.paddingStart;else if(this.options.lanes===1){const h=u.length-1,m=(i=this._singleLaneMeasurements)==null?void 0:i.flat;m!=null?d=m[h*2]+m[h*2+1]:d=((r=u[h])==null?void 0:r.end)??0}else{const h=Array(this.options.lanes).fill(null);let m=u.length-1;for(;m>=0&&h.some(p=>p===null);){const p=u[m];h[p.lane]===null&&(h[p.lane]=p.end),m--}d=Math.max(...h.filter(p=>p!==null))}return Math.max(d-this.options.scrollMargin+this.options.paddingEnd,0)},this.takeSnapshot=()=>{const i=[];if(this.itemSizeCache.size===0)return i;const r=this.getMeasurements();for(const u of r)u&&this.itemSizeCache.has(u.key)&&i.push({index:u.index,key:u.key,start:u.start,size:u.size,end:u.end,lane:u.lane});return i},this._scrollToOffset=(i,{adjustments:r,behavior:u})=>{this._intendedScrollOffset=i+(r??0),this.options.scrollToFn(i,{behavior:u,adjustments:r},this)},this.measure=()=>{this.pendingMin=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.itemSizeCacheVersion++,this.notify(!1)},this.setOptions(s)}applyScrollAdjustment(s,i){if(s===0)return!1;if(ch()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded))return this._iosDeferredAdjustment+=s,!1;{const r=this.getScrollOffset()+this.scrollAdjustments+s,u=this.scrollElement,d=u!==null&&("scrollHeight"in u||"document"in u)?this.getMaxScrollOffset():null;return this._clampedAdjustment=d!==null&&r>d+.5?{target:r,maxAtWrite:d}:null,this._scrollToOffset(this.getScrollOffset(),{adjustments:this.scrollAdjustments+=s,behavior:i}),this.scrollOffset!==null&&(this.scrollOffset+=this.scrollAdjustments,this.scrollOffset<0&&(this.scrollOffset=0),this.scrollAdjustments=0),!0}}scheduleScrollReconcile(){if(!this.targetWindow){this.scrollState=null;return}this.rafId==null&&(this.rafId=this.targetWindow.requestAnimationFrame(()=>{this.rafId=null,this.reconcileScroll()}))}reconcileScroll(){if(!this.scrollState||!this.scrollElement)return;if(this.now()-this.scrollState.startedAt>5e3){this.scrollState=null;return}const r=this.scrollState.index!=null?this.getOffsetForIndex(this.scrollState.index,this.scrollState.align):void 0,u=r?r[0]:this.scrollState.lastTargetOffset,d=1,h=u!==this.scrollState.lastTargetOffset;if(!h&&Dy(u,this.getScrollOffset())){if(this.scrollState.stableFrames++,this.scrollState.stableFrames>=d){this.getScrollOffset()!==u&&this._scrollToOffset(u,{adjustments:void 0,behavior:"auto"}),this.scrollState=null;return}}else if(this.scrollState.stableFrames=0,h){const m=this.getSize()||600,p=Math.abs(u-this.getScrollOffset()),y=this.scrollState.behavior==="smooth"&&p>m;this.scrollState.lastTargetOffset=u,y||(this.scrollState.behavior="auto"),this._scrollToOffset(u,{adjustments:void 0,behavior:y?"smooth":"auto"})}this.scheduleScrollReconcile()}}const S1=(n,s,i,r)=>{for(;n<=s;){const u=(n+s)/2|0,d=i(u);if(d<r)n=u+1;else if(d>r)s=u-1;else return u}return n>0?n-1:0};function _E(n,s,i){let r=0;for(;r<=s;){const u=(r+s)/2|0,d=n[u*2];if(d<i)r=u+1;else if(d>i)s=u-1;else return u}return r>0?r-1:0}function RE(n,s,i,r,u){const 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es={deletion:"var(--sv-del)","tandem-duplication":"var(--sv-dup)",inversion:"var(--sv-inv)",translocation:"var(--sv-tra)"},IE={deletion:"Deletion","tandem-duplication":"Tandem dup.",inversion:"Inversion",translocation:"Transl."},XE={"<1kb":"<1k","1kb-10kb":"10k","10kb-100kb":"100k","100kb-1Mb":"1M",">1Mb":">1M"};function KE(n){return n.size?XE[n.size]??n.size:""}function Uy(n){const s=`${n.clustered?"Clustered":"Dispersed"} ${bm[n.sv_class].toLowerCase()}s`;return n.size?`${s}, ${FE(n.size)}`:s}function ZE(n){const s=[];return n.forEach((i,r)=>{const u=s[s.length-1];u&&u.clustered===i.clustered&&u.sv_class===i.sv_class?u.end=r:s.push({clustered:i.clustered,sv_class:i.sv_class,start:r,end:r})}),s}function PE(n){const s=new Map;for(const i of n)s.set(i.sv_class,(s.get(i.sv_class)??0)+i.count);return[...s].map(([i,r])=>({sv_class:i,count:r}))}const JE=45;function WE({role:n}){return n?f.jsx("span",{className:`sc-pill 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f.jsxs("button",{type:"button",className:"vt-sort","data-active":!!s,onClick:i,title:`Sort by ${n.toLowerCase()}`,children:[n,s==="desc"?f.jsx(Fu,{size:12,"aria-hidden":!0}):s==="asc"?f.jsx(Ux,{size:12,"aria-hidden":!0}):f.jsx(Fu,{size:12,"aria-hidden":!0,className:"vt-sort-idle"})]})}function nM({row:n,onLocate:s}){const[i,r]=C.useState(!1),u=n.left_chrom&&n.left_pos!==null?{chrom:n.left_chrom,pos:n.left_pos}:null,d=n.right_chrom&&n.right_pos!==null?{chrom:n.right_chrom,pos:n.right_pos}:null,h=[["Type",wm(n.sv_type)],["Left breakpoint",u?`${Yr(u.chrom,u.pos)}${n.left_loc?`, ${n.left_loc}`:""}`:"–"],["Right breakpoint",d?`${Yr(d.chrom,d.pos)}${n.right_loc?`, ${n.right_loc}`:""}`:"–"],["Pileups (left, right)",[n.left_pileup,n.right_pileup].filter(Boolean).join(", ")||"–"],["Orientation",n.orientation??"–"],["Callers",C1(n.callers)]],m=n.gene??n.left_gene,p=n.gene??n.right_gene;return f.jsxs("div",{className:"vt-detail-body",children:[f.jsx("dl",{className:"vt-facts",children:h.map(([y,x])=>f.jsxs("div",{children:[f.jsx("dt",{children:y}),f.jsx("dd",{children:x})]},y))}),f.jsxs("div",{className:"flex flex-wrap items-center gap-2",children:[u&&f.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:()=>s({...u,gene:m}),children:[f.jsx(Bh,{size:14,"aria-hidden":!0}),"Show ",d&&d.chrom===u.chrom?"it":"left breakpoint"," on copy number"]}),d&&d.chrom!==(u==null?void 0:u.chrom)&&f.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:()=>s({...d,gene:p}),children:[f.jsx(Bh,{size:14,"aria-hidden":!0}),"Show right breakpoint on copy number"]}),n.igv_locus&&f.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:async()=>{try{await navigator.clipboard.writeText(n.igv_locus??""),r(!0),window.setTimeout(()=>r(!1),1500)}catch{window.prompt("Copy these IGV loci",n.igv_locus??"")}},children:[f.jsx(Fx,{size:14,"aria-hidden":!0}),i?"Copied":"Copy 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0:R.className,"aria-sort":E?E==="desc"?"descending":"ascending":void 0,children:M.column.getCanSort()?f.jsx(tM,{label:String(M.column.columnDef.header),sorted:E,onClick:M.column.getToggleSortingHandler()}):Qu(M.column.columnDef.header,M.getContext())},M.id)})},N.id))}),f.jsx(w1,{items:b.getRowModel().rows,scrollRef:y,columnCount:w,rowHeight:j,getKey:N=>N.id,render:N=>f.jsxs(f.Fragment,{children:[f.jsx("tr",{className:"vt-row","data-expanded":N.getIsExpanded(),onClick:()=>N.toggleExpanded(),children:N.getVisibleCells().map(M=>{var R;return f.jsx("td",{className:(R=M.column.columnDef.meta)==null?void 0:R.className,children:Qu(M.column.columnDef.cell,M.getContext())},M.id)})}),N.getIsExpanded()&&f.jsx("tr",{className:"vt-detail",children:f.jsx("td",{colSpan:w,children:f.jsx(nM,{row:N.original,onLocate:u})})})]})})]})}),f.jsx(sc,{shown:s.length,total:i,noun:["row","rows"]})]})}const zr=176,dh=34,hh=7,mh=22,Lu=30,lM={deletion:"Del","tandem-duplication":"Dup",inversion:"Inv",translocation:"Tra"};function aM(n,s){return[bm[n],IE[n],lM[n]].find(r=>wa(r,12)+8<=s)??""}function sM(n,s,i,r,u){const d=Math.min(u,i/2,r);return`M${n},${s+r} V${s+d} Q${n},${s} ${n+d},${s} H${n+i-d} Q${n+i},${s} ${n+i},${s+d} V${s+r} Z`}function iM({categories:n,total:s,litClass:i}){const[r,u]=Oi(),d=C.useId(),[h,m]=C.useState(null),p=ZE(n),y=Math.max(0,...n.map(k=>k.count)),x=r1(y,3),v=x[x.length-1],b=n.length,w=(p.length-1)*hh,j=n.some(k=>k.clustered)&&n.some(k=>!k.clustered),N=Math.max((u-Lu-6-w-(j?mh-hh:0))/b,4),M=Math.min(26,N*.64),R=[],E=[];let U=Lu;p.forEach((k,ne)=>{ne>0&&(U+=p[ne-1].clustered!==k.clustered?mh:hh);const oe=U;for(let W=k.start;W<=k.end;W++)R[W]=U+(N-M)/2,U+=N;const ie=E.find(W=>W.clustered===k.clustered&&W.x1>=oe-mh-1),Y=n.slice(k.start,k.end+1).reduce((W,X)=>W+X.count,0);ie?(ie.x1=U,ie.count+=Y):E.push({clustered:k.clustered,x0:oe,x1:U,count:Y})});const T=k=>dh+zr-k/v*zr,H=dh+zr,D=k=>h!==null?k===h:i?n[k].sv_class===i:!0,O=h===null?null:n[h],I=O&&s?Math.round(O.count/s*100):0,ee=H+62;return f.jsxs("div",{ref:r,className:"rs","data-lit":h!==null||i?"":void 0,children:[f.jsxs("svg",{width:u,height:ee,role:"img","aria-label":`Rearrangement signatures: ${n.filter(k=>k.count>0).map(k=>`${k.category} ${k.count}`).join(", ")}`,children:[f.jsx("defs",{children:Object.keys(es).map(k=>f.jsxs("linearGradient",{id:`${d}-${k}`,x1:"0",y1:"0",x2:"0",y2:"1",children:[f.jsx("stop",{offset:"0",style:{stopColor:es[k]}}),f.jsx("stop",{offset:"1",style:{stopColor:es[k]},stopOpacity:.72})]},k))}),E.map(k=>f.jsxs("g",{children:[j&&k.clustered&&f.jsx("rect",{x:k.x0-6,y:0,width:k.x1-k.x0+12,height:H+56,rx:14,className:"rs-zone"}),j&&f.jsxs("text",{x:k.x0,y:17,className:"rs-zone-name",children:[k.clustered?"Clustered":"Dispersed",f.jsxs("tspan",{className:"rs-zone-n",children:[" 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the search"})]}),v.length>0&&f.jsxs("section",{className:"sv-table","aria-label":"Rearranged oncogenes and tumour suppressors",children:[f.jsx("h3",{className:"sv-h",children:"Rearranged oncogenes and tumour suppressors"}),f.jsx($y,{kind:"onco",rows:v,total:n.onco.length,query:s,onLocate:r})]}),b.length>0&&f.jsxs("section",{className:"sv-table","aria-label":"Whole-gene rearrangements",children:[f.jsx("h3",{className:"sv-h",children:"Whole-gene rearrangements"}),f.jsx($y,{kind:"whole_gene",rows:b,total:n.whole_gene.length,query:s,onLocate:r})]})]})}const uM=C.forwardRef(function({envelope:s,loading:i,picked:r,onLocate:u},d){const h=(s==null?void 0:s.status)==="ok"?s.data:null,[m,p]=C.useState("");return f.jsx(nc,{ref:d,title:"Structural variants",subtitle:h?N1(h.rearrangements,"rearrangement","rearrangements"):void 0,lineage:(s==null?void 0:s.lineage)??[],picked:r,info:"structuralVariants",className:"svs",expandable:!0,children:f.jsx(to,{label:"structural 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u=this.options.enabled?this.options.getScrollElement():null;if(this.scrollElement!==u){if(this.cleanup(),!u){this.maybeNotify();return}if(this.scrollElement=u,this.scrollElement&&"ownerDocument"in this.scrollElement?this.targetWindow=this.scrollElement.ownerDocument.defaultView:this.targetWindow=((i=this.scrollElement)==null?void 0:i.window)??null,this.elementsCache.forEach(h=>{this.observer.observe(h)}),this.unsubs.push(this.options.observeElementRect(this,h=>{this.scrollRect=h,this.maybeNotify()})),this.unsubs.push(this.options.observeElementOffset(this,(h,m)=>{if(m&&this._intendedScrollOffset===null&&h===this.scrollOffset)return;this._intendedScrollOffset!==null&&Math.abs(h-this._intendedScrollOffset)<1.5&&(h=this._intendedScrollOffset),this._intendedScrollOffset=null,this._clampedAdjustment!==null&&Math.abs(h-this._clampedAdjustment.maxAtWrite)>=1.5&&(this._clampedAdjustment=null),this.scrollAdjustments=0;const g=this.getScrollOffset();this.scrollDirection=m?g===h?this.scrollDirection:g<h?"forward":"backward":null,this.scrollOffset=h,this.isScrolling=m,this._flushIosDeferredIfReady(),this.scrollState&&this.scheduleScrollReconcile(),this.maybeNotify()})),"addEventListener"in this.scrollElement){const h=this.scrollElement,m=()=>{this._iosTouching=!0,this._iosJustTouchEnded=!1,this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)},g=()=>{this._iosTouching=!1,!(!Nh()||this.targetWindow==null)&&(this._iosJustTouchEnded=!0,this._iosTouchEndTimerId=this.targetWindow.setTimeout(()=>{this._iosJustTouchEnded=!1,this._iosTouchEndTimerId=null,this._flushIosDeferredIfReady()},150))};h.addEventListener("touchstart",m,sc),h.addEventListener("touchend",g,sc),this.unsubs.push(()=>{h.removeEventListener("touchstart",m),h.removeEventListener("touchend",g),this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)})}this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})}const d=this.pendingScrollAnchor;if(this.pendingScrollAnchor=null,d&&this.scrollElement&&this.options.enabled){const[h,m,g,y]=d;h!==null&&!g&&(Nh()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded)?y!==0&&(this._iosDeferredAdjustment+=y):((o=this.scrollState)==null?void 0:o.behavior)==="smooth"&&!ex(this.getScrollOffset()-y,this.scrollState.lastTargetOffset)||this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})),g&&this.scrollToEnd({behavior:g})}this._retryClampedAdjustment()},this._retryClampedAdjustment=()=>{if(this._clampedAdjustment===null||!this.scrollElement||!this.options.enabled)return;const{target:i,maxAtWrite:o}=this._clampedAdjustment,u=this.getMaxScrollOffset();u>o+.5&&(this._clampedAdjustment=i>u+.5?{target:i,maxAtWrite:u}:null,this._scrollToOffset(i,{adjustments:void 0,behavior:void 0}))},this._flushIosDeferredIfReady=()=>{if(this._iosDeferredAdjustment===0||this.isScrolling||this._iosTouching||this._iosJustTouchEnded)return;const i=this.getScrollOffset(),o=this.getMaxScrollOffset();if(i<0||i>o)return;if(this._iosDeferredAdjustment<0&&i>=o-1){this._iosDeferredAdjustment=0;return}const u=this._iosDeferredAdjustment;this._iosDeferredAdjustment=0,this._scrollToOffset(i,{adjustments:this.scrollAdjustments+=u,behavior:void 0})},this.rafId=null,this.getSize=()=>this.options.enabled?(this.scrollRect=this.scrollRect??this.options.initialRect,this.scrollRect[this.options.horizontal?"width":"height"]):(this.scrollRect=null,0),this.getScrollOffset=()=>this.options.enabled?(this.scrollOffset=this.scrollOffset??(typeof this.options.initialOffset=="function"?this.options.initialOffset():this.options.initialOffset),this.scrollOffset):(this.scrollOffset=null,0),this.getMeasurementOptions=yi(()=>[this.options.count,this.options.paddingStart,this.options.scrollMargin,this.options.getItemKey,this.options.enabled,this.options.lanes,this.options.laneAssignmentMode,this.options.gap],(i,o,u,d,h,m,g,y)=>(this.prevLanes!==void 0&&this.prevLanes!==m&&(this.lanesChangedFlag=!0),this.prevLanes=m,this.pendingMin=null,{count:i,paddingStart:o,scrollMargin:u,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:g,gap:y}),{key:!1}),this.isIndexInRange=i=>i>=0&&i<this.options.count,this.getMeasurements=yi(()=>[this.getMeasurementOptions(),this.itemSizeCacheVersion],({count:i,paddingStart:o,scrollMargin:u,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:g,gap:y},x)=>{var v;const S=this.itemSizeCache;if(!h)return this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),[];if(this.laneAssignments.size>i)for(const C of this.laneAssignments.keys())C>=i&&this.laneAssignments.delete(C);this.lanesChangedFlag&&(this.lanesChangedFlag=!1,this.lanesSettling=!0,this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.pendingMin=null),this.measurementsCache.length===0&&!this.lanesSettling&&(this.measurementsCache=this.options.initialMeasurementsCache,this.measurementsCache.forEach(C=>{this.itemSizeCache.set(C.key,C.size)}));const w=this.lanesSettling?0:this.pendingMin??0;if(this.pendingMin=null,this.lanesSettling&&this.measurementsCache.length===i&&(this.lanesSettling=!1),m===1){const C=i*2;let D=(v=this._singleLaneMeasurements)==null?void 0:v.flat;if(!D||D.length<C){const R=new Float64Array(C);D&&w>0&&R.set(D.subarray(0,w*2)),D=R}const O=w===0?new Array(i):this._singleLaneMeasurements.items.slice();let z;if(w===0)z=o+u;else{const R=w-1;z=D[R*2]+D[R*2+1]+y}for(let R=w;R<i;R++){const Q=d(R);O[R]=Q;const K=S.get(Q),$=typeof K=="number"?K:this.options.estimateSize(R);D[R*2]=z,D[R*2+1]=$,z+=$+y}this._singleLaneMeasurements={flat:D,items:O};const _=ZE(O,D);return this.measurementsCache=_,_}const j=this.measurementsCache.slice(0,w),N=new Array(m).fill(void 0),M=new Float64Array(m);let A=0;for(let C=0;C<w;C++){const D=j[C];D&&(N[D.lane]===void 0&&A++,N[D.lane]=C,M[D.lane]=D.end)}for(let C=w;C<i;C++){const D=d(C),O=this.laneAssignments.get(C);let z,_;const R=g==="estimate"||S.has(D);if(O!==void 0&&this.options.lanes>1){z=O;const le=N[z],oe=le!==void 0?j[le]:void 0;_=oe?oe.end+y:o+u}else if(A===m){let le=0,oe=M[0],te=N[0];for(let Y=1;Y<m;Y++){const ee=M[Y];(ee<oe||ee===oe&&N[Y]<te)&&(le=Y,oe=ee,te=N[Y])}z=le,_=oe+y,R&&this.laneAssignments.set(C,z)}else z=C%this.options.lanes,_=o+u,R&&this.laneAssignments.set(C,z);const Q=S.get(D),K=typeof Q=="number"?Q:this.options.estimateSize(C),$=_+K;j[C]={index:C,start:_,size:K,end:$,key:D,lane:z},N[z]===void 0&&A++,N[z]=C,M[z]=$}return this.measurementsCache=j,j},{key:!1,debug:()=>this.options.debug}),this.calculateRange=yi(()=>[this.getMeasurements(),this.getSize(),this.getScrollOffset(),this.options.lanes],(i,o,u,d)=>i.length===0||o===0?(this.range=null,null):(this.range=fM(i,o,u,d,d===1&&this._singleLaneMeasurements!==null?this._singleLaneMeasurements.flat:null),this.range),{key:!1,debug:()=>this.options.debug}),this.getVirtualIndexes=yi(()=>{let i=null,o=null;const u=this.calculateRange();return u&&(i=u.startIndex,o=u.endIndex),this.maybeNotify.updateDeps([this.isScrolling,i,o]),[this.options.rangeExtractor,this.options.overscan,this.options.count,i,o]},(i,o,u,d,h)=>d===null||h===null?[]:i({startIndex:d,endIndex:h,overscan:o,count:u}),{key:!1,debug:()=>this.options.debug}),this.indexFromElement=i=>{const o=this.options.indexAttribute,u=i.getAttribute(o);return u?parseInt(u,10):(console.warn(`Missing attribute name '${o}={index}' on measured element.`),-1)},this.shouldMeasureDuringScroll=i=>{var o;if(!this.scrollState||this.scrollState.behavior!=="smooth")return!0;const u=this.scrollState.index??((o=this.getVirtualItemForOffset(this.scrollState.lastTargetOffset))==null?void 0:o.index);if(u!==void 0&&this.range){const d=Math.max(this.options.overscan,Math.ceil((this.range.endIndex-this.range.startIndex)/2)),h=Math.max(0,u-d),m=Math.min(this.options.count-1,u+d);return i>=h&&i<=m}return!0},this.measureElement=i=>{if(!i){this.elementsCache.forEach((h,m)=>{h.isConnected||(this.observer.unobserve(h),this.elementsCache.delete(m))});return}const o=this.indexFromElement(i);if(!this.isIndexInRange(o))return;const u=this.options.getItemKey(o),d=this.elementsCache.get(u);d!==i&&(d&&this.observer.unobserve(d),this.observer.observe(i),this.elementsCache.set(u,i)),(!this.isScrolling||this.scrollState)&&this.shouldMeasureDuringScroll(o)&&this.resizeItem(o,this.options.measureElement(i,void 0,this))},this.resizeItem=(i,o)=>{var u,d,h;if(!this.isIndexInRange(i))return;let m,g,y;const x=(u=this._singleLaneMeasurements)==null?void 0:u.flat;if(this.options.lanes===1&&x!=null)y=this.options.getItemKey(i),g=x[i*2],m=x[i*2+1];else{const w=this.measurementsCache[i];if(!w)return;y=w.key,g=w.start,m=w.size}const v=this.itemSizeCache.get(y)??m,S=o-v;if(S!==0){const w=this.options.anchorTo==="end"&&((d=this.scrollState)==null?void 0:d.behavior)!=="smooth"&&this.getVirtualDistanceFromEnd()<=this.options.scrollEndThreshold,j=w?this.getTotalSize():0,N=this.getScrollOffset()+this.scrollAdjustments,A=!this.itemSizeCache.has(y)?g<N:g+v<=N&&this.scrollDirection!=="backward",C=((h=this.scrollState)==null?void 0:h.behavior)!=="smooth"&&(this.shouldAdjustScrollPositionOnItemSizeChange!==void 0?this.shouldAdjustScrollPositionOnItemSizeChange(this.measurementsCache[i]??{index:i,key:y,start:g,size:m,end:g+m,lane:0},S,this):A);(this.pendingMin===null||i<this.pendingMin)&&(this.pendingMin=i),this.itemSizeCache.set(y,o),this.itemSizeCacheVersion++;let D=!1;w?D=this.applyScrollAdjustment(this.getTotalSize()-j):C&&(D=this.applyScrollAdjustment(S)),this.notify(D),this._retryClampedAdjustment()}},this.getVirtualItems=yi(()=>[this.getVirtualIndexes(),this.getMeasurements()],(i,o)=>{const u=[];for(let d=0,h=i.length;d<h;d++){const m=i[d],g=o[m];u.push(g)}return u},{key:!1,debug:()=>this.options.debug}),this.getVirtualItemForOffset=i=>{var o;const u=this.getMeasurements();if(u.length===0)return;const d=(o=this._singleLaneMeasurements)==null?void 0:o.flat,h=this.options.lanes===1&&d!=null,m=U1(0,u.length-1,h?g=>d[g*2]:g=>Wy(u[g]).start,i);return Wy(u[m])},this.getMaxScrollOffset=()=>{if(!this.scrollElement)return 0;if("scrollHeight"in this.scrollElement)return this.options.horizontal?this.scrollElement.scrollWidth-this.scrollElement.clientWidth:this.scrollElement.scrollHeight-this.scrollElement.clientHeight;{const i=this.scrollElement.document.documentElement;return this.options.horizontal?i.scrollWidth-this.scrollElement.innerWidth:i.scrollHeight-this.scrollElement.innerHeight}},this.getVirtualDistanceFromEnd=()=>Math.max(this.getTotalSize()-this.getSize()-this.getScrollOffset(),0),this.getDistanceFromEnd=()=>Math.max(this.getMaxScrollOffset()-this.getScrollOffset(),0),this.isAtEnd=(i=this.options.scrollEndThreshold)=>this.getDistanceFromEnd()<=i,this.getOffsetForAlignment=(i,o,u=0)=>{if(!this.scrollElement)return 0;const d=this.getSize(),h=this.getScrollOffset();o==="auto"&&(o=i>=h+d?"end":"start"),o==="center"?i+=(u-d)/2:o==="end"&&(i-=d);const m=this.getMaxScrollOffset();return Math.max(Math.min(m,i),0)},this.getOffsetForIndex=(i,o="auto")=>{i=Math.max(0,Math.min(i,this.options.count-1));const u=this.getSize(),d=this.getScrollOffset(),h=this.measurementsCache[i];if(!h)return;if(o==="auto")if(h.end>=d+u-this.options.scrollPaddingEnd)o="end";else if(h.start<=d+this.options.scrollPaddingStart)o="start";else return[d,o];if(o==="end"&&i===this.options.count-1)return[this.getMaxScrollOffset(),o];const m=o==="end"?h.end+this.options.scrollPaddingEnd:h.start-this.options.scrollPaddingStart;return[this.getOffsetForAlignment(m,o,h.size),o]},this.scrollToOffset=(i,{align:o="start",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0;const d=this.getOffsetForAlignment(i,o),h=this.now();this.scrollState={index:null,align:o,behavior:u,startedAt:h,lastTargetOffset:d,stableFrames:0},this._scrollToOffset(d,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollToIndex=(i,{align:o="auto",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0,i=Math.max(0,Math.min(i,this.options.count-1));const d=this.getOffsetForIndex(i,o);if(!d)return;const[h,m]=d,g=this.now();this.scrollState={index:i,align:m,behavior:u,startedAt:g,lastTargetOffset:h,stableFrames:0},this._scrollToOffset(h,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollBy=(i,{behavior:o="auto"}={})=>{const u=this.getScrollOffset()+i,d=this.now();this.scrollState={index:null,align:"start",behavior:o,startedAt:d,lastTargetOffset:u,stableFrames:0},this._scrollToOffset(u,{adjustments:void 0,behavior:o}),this.scheduleScrollReconcile()},this.scrollToEnd=({behavior:i="auto"}={})=>{if(this.options.count>0){this.scrollToIndex(this.options.count-1,{align:"end",behavior:i});return}this.scrollToOffset(Math.max(this.getTotalSize()-this.getSize(),0),{behavior:i})},this.getTotalSize=()=>{var i,o;const u=this.getMeasurements();let d;if(u.length===0)d=this.options.paddingStart;else if(this.options.lanes===1){const h=u.length-1,m=(i=this._singleLaneMeasurements)==null?void 0:i.flat;m!=null?d=m[h*2]+m[h*2+1]:d=((o=u[h])==null?void 0:o.end)??0}else{const h=Array(this.options.lanes).fill(null);let m=u.length-1;for(;m>=0&&h.some(g=>g===null);){const g=u[m];h[g.lane]===null&&(h[g.lane]=g.end),m--}d=Math.max(...h.filter(g=>g!==null))}return Math.max(d-this.options.scrollMargin+this.options.paddingEnd,0)},this.takeSnapshot=()=>{const i=[];if(this.itemSizeCache.size===0)return i;const o=this.getMeasurements();for(const u of o)u&&this.itemSizeCache.has(u.key)&&i.push({index:u.index,key:u.key,start:u.start,size:u.size,end:u.end,lane:u.lane});return i},this._scrollToOffset=(i,{adjustments:o,behavior:u})=>{this._intendedScrollOffset=i+(o??0),this.options.scrollToFn(i,{behavior:u,adjustments:o},this)},this.measure=()=>{this.pendingMin=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.itemSizeCacheVersion++,this.notify(!1)},this.setOptions(a)}applyScrollAdjustment(a,i){if(a===0)return!1;if(Nh()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded))return this._iosDeferredAdjustment+=a,!1;{const o=this.getScrollOffset()+this.scrollAdjustments+a,u=this.scrollElement,d=u!==null&&("scrollHeight"in u||"document"in u)?this.getMaxScrollOffset():null;return this._clampedAdjustment=d!==null&&o>d+.5?{target:o,maxAtWrite:d}:null,this._scrollToOffset(this.getScrollOffset(),{adjustments:this.scrollAdjustments+=a,behavior:i}),this.scrollOffset!==null&&(this.scrollOffset+=this.scrollAdjustments,this.scrollOffset<0&&(this.scrollOffset=0),this.scrollAdjustments=0),!0}}scheduleScrollReconcile(){if(!this.targetWindow){this.scrollState=null;return}this.rafId==null&&(this.rafId=this.targetWindow.requestAnimationFrame(()=>{this.rafId=null,this.reconcileScroll()}))}reconcileScroll(){if(!this.scrollState||!this.scrollElement)return;if(this.now()-this.scrollState.startedAt>5e3){this.scrollState=null;return}const o=this.scrollState.index!=null?this.getOffsetForIndex(this.scrollState.index,this.scrollState.align):void 0,u=o?o[0]:this.scrollState.lastTargetOffset,d=1,h=u!==this.scrollState.lastTargetOffset;if(!h&&ex(u,this.getScrollOffset())){if(this.scrollState.stableFrames++,this.scrollState.stableFrames>=d){this.getScrollOffset()!==u&&this._scrollToOffset(u,{adjustments:void 0,behavior:"auto"}),this.scrollState=null;return}}else if(this.scrollState.stableFrames=0,h){const m=this.getSize()||600,g=Math.abs(u-this.getScrollOffset()),y=this.scrollState.behavior==="smooth"&&g>m;this.scrollState.lastTargetOffset=u,y||(this.scrollState.behavior="auto"),this._scrollToOffset(u,{adjustments:void 0,behavior:y?"smooth":"auto"})}this.scheduleScrollReconcile()}}const U1=(n,a,i,o)=>{for(;n<=a;){const u=(n+a)/2|0,d=i(u);if(d<o)n=u+1;else if(d>o)a=u-1;else return u}return n>0?n-1:0};function cM(n,a,i){let o=0;for(;o<=a;){const u=(o+a)/2|0,d=n[u*2];if(d<i)o=u+1;else if(d>i)a=u-1;else return u}return o>0?o-1:0}function fM(n,a,i,o,u){const d=n.length-1;if(n.length<=o)return{startIndex:0,endIndex:d};if(o===1&&u!==null){const y=cM(u,d,i);let x=y;const v=i+a;for(;x<d&&u[x*2]+u[x*2+1]<v;)x++;return{startIndex:y,endIndex:x}}let m=U1(0,d,y=>n[y].start,i),g=m;if(o===1)for(;g<d&&n[g].end<i+a;)g++;else if(o>1){const y=Array(o).fill(0);for(;g<d&&y.some(v=>v<i+a);){const v=n[g];y[v.lane]=v.end,g++}const x=Array(o).fill(i+a);for(;m>=0&&x.some(v=>v>=i);){const v=n[m];x[v.lane]=v.start,m--}m=Math.max(0,m-m%o),g=Math.min(d,g+(o-1-g%o))}return{startIndex:m,endIndex:g}}const Ch=typeof document<"u"?E.useLayoutEffect:E.useEffect;function dM({useFlushSync:n=!0,directDomUpdates:a=!1,directDomUpdatesMode:i="transform",...o}){const u=E.useReducer(v=>v+1,0)[1],d=E.useRef({enabled:a,mode:i,container:null,lastSize:null,lastPositions:new WeakMap,prevRange:null});d.current.enabled=a,d.current.mode=i;const h=E.useRef(!1),m=v=>{const S=d.current;if(!S.enabled||!S.container)return;const w=v.getTotalSize();if(w!==S.lastSize){S.lastSize=w;const j=v.options.horizontal?"width":"height";S.container.style[j]=`${w}px`}},g=v=>{const S=d.current;if(!S.enabled||!S.container)return;m(v);const w=!!v.options.horizontal,j=S.mode==="transform",N=w?"left":"top",M=v.options.scrollMargin,A=v.getVirtualItems();for(const C of A){const D=C.start-M,O=v.elementsCache.get(C.key);O&&S.lastPositions.get(O)!==D&&(S.lastPositions.set(O,D),j?O.style.transform=w?`translate3d(${D}px, 0, 0)`:`translate3d(0, ${D}px, 0)`:O.style[N]=`${D}px`)}},y={...o,onChange:(v,S)=>{var w;const j=d.current;let N=!0;if(j.enabled){g(v);const M=v.range,A=j.prevRange;N=!A||A.isScrolling!==v.isScrolling||A.startIndex!==(M==null?void 0:M.startIndex)||A.endIndex!==(M==null?void 0:M.endIndex),N&&(j.prevRange=M?{startIndex:M.startIndex,endIndex:M.endIndex,isScrolling:v.isScrolling}:null)}N&&(n&&S&&!h.current?jm.flushSync(u):u()),(w=o.onChange)==null||w.call(o,v,S)}},[x]=E.useState(()=>{const v=new uM(y),S=v.measureElement;return v.measureElement=w=>{h.current=!0;try{S(w)}finally{h.current=!1}},Object.assign(v,{containerRef:w=>{const j=d.current;if(j.container=w,j.lastSize=null,w&&j.enabled){const N=v.getTotalSize();j.lastSize=N;const M=v.options.horizontal?"width":"height";w.style[M]=`${N}px`}}})});return x.setOptions(y),Ch(()=>x._didMount(),[]),Ch(()=>(m(x),x._willUpdate())),Ch(()=>{g(x)}),x}function hM(n){return dM({observeElementRect:tM,observeElementOffset:aM,scrollToFn:oM,...n})}const $1=33,xi=32,mM=25;function V1({items:n,scrollRef:a,columnCount:i,getKey:o,render:u,onEndReached:d,endThreshold:h=15,rowHeight:m=$1}){var M;const g=hM({count:n.length,getScrollElement:()=>a.current,estimateSize:()=>m,overscan:8,scrollMargin:xi,getItemKey:A=>o(n[A],A),initialRect:{width:1e3,height:xi+m*10}}),y=!((M=g.scrollRect)!=null&&M.height),x=y?n.slice(0,mM).map((A,C)=>({key:o(A,C),index:C,start:xi+C*m,end:xi+(C+1)*m})):g.getVirtualItems(),v=x[0],S=x[x.length-1],w=(S==null?void 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u=a[a.length-1];u&&u.clustered===i.clustered&&u.sv_class===i.sv_class?u.end=o:a.push({clustered:i.clustered,sv_class:i.sv_class,start:o,end:o})}),a}function zM(n){const a=new Map;for(const i of n)a.set(i.sv_class,(a.get(i.sv_class)??0)+i.count);return[...a].map(([i,o])=>({sv_class:i,count:o}))}const DM=45;function LM({role:n}){return n?c.jsx("span",{className:`sc-pill p-${n==="oncogene"?"onco":n}`,children:zm[n]}):c.jsx("span",{style:{color:"var(--chev)"},children:"–"})}function HM({rows:n,shown:a,onToggle:i}){const o=EM(n);return c.jsx("div",{className:"sv-legend",role:"group","aria-label":"Show rows by gene role",children:F1.filter(u=>o[u]>0).map(u=>c.jsxs("button",{type:"button",className:`sv-legend-item p-${u==="oncogene"?"onco":u}`,"aria-pressed":a.includes(u),onClick:()=>i(u),children:[zm[u],c.jsx("span",{className:"sv-legend-n",children:o[u]})]},u))})}function ax({gene:n,chrom:a,pos:i,loc:o,query:u}){return c.jsxs(c.Fragment,{children:[c.jsxs("span",{className:"sv-end",children:[c.jsx("span",{className:"vt-gene",children:c.jsx(xs,{text:n||"–",query:u})}),o&&c.jsx("span",{className:"sv-loc",children:o})]}),c.jsx("span",{className:"vt-sub stack mono",children:a&&i!==null?lr(a,i):"–"})]})}function k1(n){return n?n.replace(/,\s*/g,", "):"–"}function UM({label:n,sorted:a,onClick:i}){return c.jsxs("button",{type:"button",className:"vt-sort","data-active":!!a,onClick:i,title:`Sort by ${n.toLowerCase()}`,children:[n,a==="desc"?c.jsx(Ju,{size:12,"aria-hidden":!0}):a==="asc"?c.jsx(Wx,{size:12,"aria-hidden":!0}):c.jsx(Ju,{size:12,"aria-hidden":!0,className:"vt-sort-idle"})]})}function $M({row:n,onLocate:a}){const[i,o]=E.useState(!1),u=n.left_chrom&&n.left_pos!==null?{chrom:n.left_chrom,pos:n.left_pos}:null,d=n.right_chrom&&n.right_pos!==null?{chrom:n.right_chrom,pos:n.right_pos}:null,h=[["Type",Lm(n.sv_type)],["Left breakpoint",u?`${lr(u.chrom,u.pos)}${n.left_loc?`, ${n.left_loc}`:""}`:"–"],["Right 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