wgts-report 0.1.5 → 0.1.7

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Files changed (5) hide show
  1. package/dist/assets/wgts-report.css +1 -1
  2. package/dist/assets/wgts-report.js +65 -56
  3. package/dist/index.html +2 -2
  4. package/package.json +1 -1
  5. package/dist/assets/EChart-DTluBlbi.js +0 -37
package/dist/assets/wgts-report.js CHANGED
@@ -1,4 +1,4 @@
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  * @license React
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  * scheduler.production.js
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  *
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  *
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  * This source code is licensed under the MIT license found in the
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  * @license React
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  *
@@ -30,7 +30,7 @@ var Kv=n=>{throw TypeError(n)};var fd=(n,i,s)=>i.has(n)||Kv("Cannot "+s);var z=(
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  *
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  * This source code is licensed under the MIT license found in the
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u?u(o):o}fetchQuery(n){const i=this.defaultQueryOptions(n);i.retry===void 0&&(i.retry=!1);const s=z(this,We).build(this,i);return s.isStaleByTime(Pe(i.staleTime,s))?s.fetch(i):Promise.resolve(s.state.data)}prefetchQuery(n){return this.fetchQuery(n).then(Xt).catch(Xt)}infiniteQuery(n){return n._type="infinite",this.query(n)}fetchInfiniteQuery(n){return n._type="infinite",this.fetchQuery(n)}prefetchInfiniteQuery(n){return this.fetchInfiniteQuery(n).then(Xt).catch(Xt)}ensureInfiniteQueryData(n){return n._type="infinite",this.ensureQueryData(n)}resumePausedMutations(){return pu.isOnline()?z(this,Il).resumePausedMutations():Promise.resolve()}getQueryCache(){return z(this,We)}getMutationCache(){return z(this,Il)}getDefaultOptions(){return z(this,Xl)}setDefaultOptions(n){J(this,Xl,n)}setQueryDefaults(n,i){z(this,Zi).set(mo(n),{queryKey:n,defaultOptions:i})}getQueryDefaults(n){const i=[...z(this,Zi).values()],s={};return 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WeakMap,Kl=new WeakMap,Ji=new WeakMap,Wi=new WeakMap,ly);const Sy=T.createContext(!1),r2=()=>T.useContext(Sy);Sy.Provider;function u2(){let n=!1;return{clearReset:()=>{n=!1},reset:()=>{n=!0},isReset:()=>n}}const c2=T.createContext(u2()),f2=()=>T.useContext(c2),d2=(n,i,s)=>{const o=(s==null?void 0:s.state.status)==="error"&&typeof n.throwOnError=="function"?dy(n.throwOnError,[s.state.error,s]):n.throwOnError;(n.suspense||o)&&(i.isReset()||(n.retryOnMount=!1))},h2=n=>{T.useEffect(()=>{n.clearReset()},[n])},m2=({result:n,errorResetBoundary:i,throwOnError:s,query:o,suspense:u})=>n.isError&&!i.isReset()&&!n.isFetching&&o&&(u&&n.data===void 0||dy(s,[n.error,o])),g2=n=>{if(n.suspense){const s=u=>u==="static"?u:Math.max(u??1e3,1e3),o=n.staleTime;n.staleTime=typeof o=="function"?(...u)=>s(o(...u)):s(o),typeof n.gcTime=="number"&&(n.gcTime=Math.max(n.gcTime,1e3))}},p2=(n,i)=>(n==null?void 0:n.suspense)&&i.isPending,v2=(n,i,s)=>i.fetchOptimistic(n).catch(()=>{s.clearReset()});function xy(n,i,s){const o=r2(),u=f2(),f=sy(),d=f.defaultQueryOptions(n),g=f.getQueryCache().get(d.queryHash),p=n.subscribed!==!1;d._optimisticResults=o?"isRestoring":p?"optimistic":void 0,g2(d),d2(d,u,g),h2(u);const[S]=T.useState(()=>new i(f,d)),y=S.getOptimisticResult(d),v=!o&&p;if(T.useSyncExternalStore(T.useCallback(b=>{const C=v?S.subscribe(Et.batchCalls(b)):Xt;return S.updateResult(),C},[S,v]),()=>S.getCurrentResult(),()=>S.getCurrentResult()),T.useEffect(()=>{S.setOptions(d)},[d,S]),p2(d,y))throw v2(d,S,u);if(m2({result:y,errorResetBoundary:u,throwOnError:d.throwOnError,query:g,suspense:d.suspense}))throw y.error;return d.notifyOnChangeProps?y:S.trackResult(y)}function ta(n,i){return xy(n,yy)}function y2(n,i){return xy(n,n2)}var by=ay();/**
48
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null;if(e!==null&&t.child!==e.child)throw Error(r(153));if(t.child!==null){for(e=t.child,l=yl(e,e.pendingProps),t.child=l,l.return=t;e.sibling!==null;)e=e.sibling,l=l.sibling=yl(e,e.pendingProps),l.return=t;l.sibling=null}return t.child}function wf(e,t){return(e.lanes&t)!==0?!0:(e=e.dependencies,!!(e!==null&&bo(e)))}function LS(e,t,l){switch(t.tag){case 3:qn(t,t.stateNode.containerInfo),Bl(t,yt,e.memoizedState.cache),La();break;case 27:case 5:fl(t);break;case 4:qn(t,t.stateNode.containerInfo);break;case 10:Bl(t,t.type,t.memoizedProps.value);break;case 31:if(t.memoizedState!==null)return t.flags|=128,Yc(t),null;break;case 13:var a=t.memoizedState;if(a!==null){if(a.dehydrated!==null)return Il(t),t.flags|=128,null;a=Va(e,t,l,!1);var o=t.child.childLanes;return a||(l&o)!==0?Dp(e,t,l):(Il(t),e=jl(e,t,l),e!==null?e.sibling:null)}Il(t);break;case 19:if(t.flags&128)return bf(e,t,l);if(o=(e.flags&128)!==0,a=(l&t.childLanes)!==0,a||(Va(e,t,l,!1),a=(l&t.childLanes)!==0),o){if(a)return bf(e,t,l);t.flags|=128}if(o=t.memoizedState,o!==null&&(o.rendering=null,o.tail=null,o.lastEffect=null),Pi(t,Ht.current),a)break;return null;case 22:return t.lanes=0,Mp(e,t,l,t.pendingProps);case 24:Bl(t,yt,e.memoizedState.cache)}return jl(e,t,l)}function Vp(e,t,l){if(e!==null)if(e.memoizedProps!==t.pendingProps)St=!0;else{if(!wf(e,l)&&(t.flags&128)===0)return St=!1,LS(e,t,l);St=(e.flags&131072)!==0}else St=!1,Re&&(t.flags&1048576)!==0&&gg(t,ki,t.index);switch(t.lanes=0,t.tag){case 16:e:{var a=t.pendingProps;if(e=ka(t.elementType),t.type=e,typeof e=="function")Mc(e)?(a=Ya(e,a),t.tag=1,t=Op(null,t,e,a,l)):(t.tag=0,t=gf(null,t,e,a,l));else{if(e!=null){var o=e.$$typeof;if(o===P){t.tag=11,t=Ep(null,t,e,a,l);break e}else if(o===Ee){t.tag=14,t=Np(null,t,e,a,l);break e}else if(o===ee){t.tag=10,t.type=e,t=Up(null,t,l);break e}}throw t=ye(e)||e,Error(r(306,t,""))}}return t;case 0:return gf(e,t,t.type,t.pendingProps,l);case 1:return a=t.type,o=Ya(a,t.pendingProps),Op(e,t,a,o,l);case 3:e:{if(qn(t,t.stateNode.containerInfo),e===null)throw Error(r(387));a=t.pendingProps;var c=t.memoizedState;o=c.element,Bc(e,t),Zi(t,a,null,l);var g=t.memoizedState;if(a=g.cache,Bl(t,yt,a),a!==c.cache&&Hc(t,[yt],l,!0),Ki(),a=g.element,c.isDehydrated)if(c={element:a,isDehydrated:!1,cache:g.cache},t.updateQueue.baseState=c,t.memoizedState=c,t.flags&256){t=zp(e,t,a,l);break e}else if(a!==o){o=jn(Error(r(424)),t),Gi(o),t=zp(e,t,a,l);break e}else{switch(e=t.stateNode.containerInfo,e.nodeType){case 9:e=e.body;break;default:e=e.nodeName==="HTML"?e.ownerDocument.body:e}for(lt=Rn(e.firstChild),Mt=t,Re=!0,$l=null,_n=!0,l=Mg(t,null,a,l),t.child=l;l;)l.flags=l.flags&-3|134221824,l=l.sibling}else{if(La(),a===o){t=jl(e,t,l);break e}jt(e,t,a,l)}t=t.child}return t;case 26:return Ls(e,t),e===null?(l=uv(t.type,null,t.pendingProps,null))?t.memoizedState=l:Re||(t.stateNode=k0(t.type,t.pendingProps,At.current,t)):t.memoizedState=uv(t.type,e.memoizedProps,t.pendingProps,e.memoizedState),null;case 27:return fl(t),e===null&&Re&&(a=t.stateNode=sv(t.type,t.pendingProps,At.current),Mt=t,_n=!0,o=lt,na(t.type)?(yd=o,lt=Rn(a.firstChild)):lt=o),jt(e,t,t.pendingProps.children,l),Ls(e,t),e===null&&(t.flags|=4194304),t.child;case 5:return e===null&&Re&&((o=a=lt)&&(a=Tb(a,t.type,t.pendingProps,_n),a!==null?(t.stateNode=a,Mt=t,lt=Rn(a.firstChild),_n=!1,o=!0):o=!1),o||Fl(t)),fl(t),o=t.type,c=t.pendingProps,g=e!==null?e.memoizedProps:null,a=c.children,ud(o,c)?a=null:g!==null&&ud(o,g)&&(t.flags|=32),t.memoizedState!==null&&(o=Kc(e,t,ES,null,null,l),ei._currentValue=o),Ls(e,t),jt(e,t,a,l),t.child;case 6:return e===null&&Re&&((e=l=lt)&&(l=Ab(l,t.pendingProps,_n),l!==null?(t.stateNode=l,Mt=t,lt=null,e=!0):e=!1),e||Fl(t)),null;case 13:return Dp(e,t,l);case 4:return qn(t,t.stateNode.containerInfo),a=t.pendingProps,e===null?t.child=qa(t,null,a,l):jt(e,t,a,l),t.child;case 11:return Ep(e,t,t.type,t.pendingProps,l);case 7:return a=t.pendingProps,Ls(e,t),jt(e,t,a,l),t.child;case 8:return jt(e,t,t.pendingProps.children,l),t.child;case 12:return jt(e,t,t.pendingProps.children,l),t.child;case 10:return Up(e,t,l);case 9:return o=t.type._context,a=t.pendingProps.children,$a(t),o=zt(o),a=a(o),t.flags|=1,jt(e,t,a,l),t.child;case 14:return Np(e,t,t.type,t.pendingProps,l);case 15:return _p(e,t,t.type,t.pendingProps,l);case 19:return bf(e,t,l);case 31:return DS(e,t,l);case 22:return Mp(e,t,l,t.pendingProps);case 24:return $a(t),a=zt(yt),e===null?(o=Vc(),o===null&&(o=tt,c=Lc(),o.pooledCache=c,c.refCount++,c!==null&&(o.pooledCacheLanes|=l),o=c),t.memoizedState={parent:a,cache:o},Fc(t),Bl(t,yt,o)):((e.lanes&l)!==0&&(Bc(e,t),Zi(t,null,null,l),Ki()),o=e.memoizedState,c=t.memoizedState,o.parent!==a?(o={parent:a,cache:a},t.memoizedState=o,t.lanes===0&&(t.memoizedState=t.updateQueue.baseState=o),Bl(t,yt,a)):(a=c.cache,Bl(t,yt,a),a!==o.cache&&Hc(t,[yt],l,!0))),jt(e,t,t.pendingProps.children,l),t.child;case 30:return t.stateNode===null&&(t.stateNode={autoName:null,paired:null,clones:null,ref:null}),a=t.pendingProps,a.name!=null&&a.name!=="auto"?t.flags|=e===null?18882560:18874368:Re&&yo(t),e!==null&&e.memoizedProps.name!==a.name?t.flags|=4194816:Ls(e,t),jt(e,t,a.children,l),t.child;case 29:throw t.pendingProps}throw Error(r(156,t.tag))}function El(e){e.flags|=4}function Cf(e,t,l,a,o){var c;if((c=(e.mode&32)!==0)&&(c=l===null?hv(t,a):hv(t,a)&&(a.src!==l.src||a.srcSet!==l.srcSet)),c){if(e.flags|=16777216,(o&335544128)===o)if(e.stateNode.complete)e.flags|=8192;else if(x0())e.flags|=8192;else throw Ga=Eo,$c}else e.flags&=-16777217}function $p(e,t){if(t.type!=="stylesheet"||(t.state.loading&4)!==0)e.flags&=-16777217;else if(e.flags|=16777216,!mv(t))if(x0())e.flags|=8192;else throw Ga=Eo,$c}function qo(e,t){t!==null&&(e.flags|=4),e.flags&16384&&(t=e.tag!==22?hm():536870912,e.lanes|=t,Bs|=t)}function nr(e,t){if(!Re)switch(e.tailMode){case"visible":break;case"collapsed":for(var l=e.tail,a=null;l!==null;)l.alternate!==null&&(a=l),l=l.sibling;a===null?t||e.tail===null?e.tail=null:e.tail.sibling=null:a.sibling=null;break;default:for(t=e.tail,l=null;t!==null;)t.alternate!==null&&(l=t),t=t.sibling;l===null?e.tail=null:l.sibling=null}}function at(e){var t=e.alternate!==null&&e.alternate.child===e.child,l=0,a=0;if(t)for(var o=e.child;o!==null;)l|=o.lanes|o.childLanes,a|=o.subtreeFlags&1206910976,a|=o.flags&1206910976,o.return=e,o=o.sibling;else for(o=e.child;o!==null;)l|=o.lanes|o.childLanes,a|=o.subtreeFlags,a|=o.flags,o.return=e,o=o.sibling;return e.subtreeFlags|=a,e.childLanes=l,t}function US(e,t,l){var a=t.pendingProps;switch(Ac(t),t.tag){case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return at(t),null;case 1:return at(t),null;case 3:return 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d=s.error;return{...r,error:d,errorUpdateCount:r.errorUpdateCount+1,errorUpdatedAt:Date.now(),fetchFailureCount:r.fetchFailureCount+1,fetchFailureReason:d,fetchStatus:"idle",status:"error",isInvalidated:!0};case"invalidate":return{...r,isInvalidated:!0};case"setState":return{...r,...s.state}}};this.state=i(this.state),$t.batch(()=>{this.observers.slice().forEach(r=>{r.onQueryUpdate()}),L(this,An).notify({query:this,type:"updated",action:s})})},By);function i1(n,s){return{fetchFailureCount:0,fetchFailureReason:null,fetchStatus:n1(s.networkMode)?"fetching":"paused",...n===void 0&&{error:null,status:"pending"}}}function Yv(n,s){return{data:n,dataUpdatedAt:s??Date.now(),error:null,isInvalidated:!1,status:"success"}}function Iv(n){const s=typeof n.initialData=="function"?n.initialData():n.initialData,i=s!==void 0,r=i?typeof n.initialDataUpdatedAt=="function"?n.initialDataUpdatedAt():n.initialDataUpdatedAt:0;return{data:s,dataUpdateCount:0,dataUpdatedAt:i?r??Date.now():0,error:null,errorUpdateCount:0,errorUpdatedAt:0,fetchFailureCount:0,fetchFailureReason:null,fetchMeta:null,isInvalidated:!1,status:i?"success":"pending",fetchStatus:"idle"}}var en,He,Gr,tn,rs,pi,Al,qr,vi,yi,os,us,ma,xi,Qe,Ar,vh,yh,xh,Sh,bh,wh,Ch,jh,ky,r1=(ky=class extends Ir{constructor(s,i){super();pe(this,Qe);pe(this,en);pe(this,He);pe(this,Gr);pe(this,tn);pe(this,rs);pe(this,pi);pe(this,Al);pe(this,qr);pe(this,vi);pe(this,yi);pe(this,os);pe(this,us);pe(this,ma);pe(this,xi,new 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Proxy(s,{get:(r,u)=>(this.trackProp(u),i==null||i(u),Reflect.get(r,u))})}trackProp(s){L(this,xi).add(s)}getCurrentQuery(){return L(this,He)}refetch({...s}={}){return this.fetch({...s})}fetchOptimistic(s){const i=L(this,en).defaultQueryOptions(s),r=L(this,en).getQueryCache().build(L(this,en),i);let u=()=>{},d;const h=new Promise(m=>{d=m,u=L(this,en).getQueryCache().subscribe(p=>{p.type==="updated"&&p.query.queryHash===r.queryHash&&r.state.data!==void 0&&(u(),m(this.createResult(r,i)))})});return Promise.race([r.fetch(i).then(()=>{const m=this.createResult(r,i);return d==null||d(m),m}).finally(()=>{u()}),h])}fetch(s){return De(this,Qe,Ar).call(this,{...s,cancelRefetch:s.cancelRefetch??!0}).then(()=>(this.updateResult(),L(this,tn)))}createResult(s,i){var D;const r=L(this,He),u=this.options,d=L(this,tn),h=L(this,rs),m=L(this,pi),p=s!==r?s.state:L(this,Gr),{state:y}=s;let x={...y},v=!1,b;if(i._optimisticResults){const z=this.hasListeners(),Y=!z&&Xv(s,i),te=z&&Kv(s,r,i,u);(Y||te)&&(x={...x,...i1(y.data,s.options)}),i._optimisticResults==="isRestoring"&&(x.fetchStatus="idle")}let{error:w,errorUpdatedAt:C,status:N}=x;b=x.data;let M=!1;if(i.placeholderData!==void 0&&b===void 0&&N==="pending"){let z;d!=null&&d.isPlaceholderData&&i.placeholderData===(m==null?void 0:m.placeholderData)?(z=d.data,M=!0):z=typeof i.placeholderData=="function"?i.placeholderData((D=L(this,yi))==null?void 0:D.state.data,L(this,yi)):i.placeholderData,z!==void 0&&(N="success",b=mh(d==null?void 0:d.data,z,i),v=!0)}if(i.select&&b!==void 0&&!M)if(d&&b===(h==null?void 0:h.data)&&i.select===L(this,qr))b=L(this,vi);else try{oe(this,qr,i.select),b=i.select(b),b=mh(d==null?void 0:d.data,b,i),oe(this,vi,b),oe(this,Al,null)}catch(z){oe(this,Al,z)}else b===void 0&&oe(this,Al,null);L(this,Al)&&(w=L(this,Al),b=L(this,vi),C=Date.now(),N="error",v=!1);const R=x.fetchStatus==="fetching",j=N==="pending",F=N==="error",T=j&&R,H=b!==void 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this.options.throwOnError&&m.add("error"),Object.keys(L(this,tn)).some(p=>{const y=p;return L(this,tn)[y]!==s[y]&&m.has(y)})})();$t.batch(()=>{u&&this.listeners.forEach(d=>{d(L(this,tn))}),L(this,en).getQueryCache().notify({query:L(this,He),type:"observerResultsUpdated"})})}onQueryUpdate(){this.updateResult(),this.hasListeners()&&De(this,Qe,bh).call(this)}},en=new WeakMap,He=new WeakMap,Gr=new WeakMap,tn=new WeakMap,rs=new WeakMap,pi=new WeakMap,Al=new WeakMap,qr=new WeakMap,vi=new WeakMap,yi=new WeakMap,os=new WeakMap,us=new WeakMap,ma=new WeakMap,xi=new WeakMap,Qe=new WeakSet,Ar=function(s){De(this,Qe,jh).call(this);let i=L(this,He).fetch(this.options,s);return s!=null&&s.throwOnError||(i=i.catch(fn)),i},vh=function(s){return!Zh()&&ft(this.options.enabled,L(this,He))!==!1&&Zy(s)},yh=function(){De(this,Qe,wh).call(this);const s=ft(this.options.staleTime,L(this,He));if(L(this,tn).isStale||!De(this,Qe,vh).call(this,s))return;const 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this.options.meta}addObserver(s){L(this,sl).includes(s)||(L(this,sl).push(s),this.clearGcTimeout(),L(this,Yt).notify({type:"observerAdded",mutation:this,observer:s}))}removeObserver(s){oe(this,sl,L(this,sl).filter(i=>i!==s)),this.scheduleGc(),L(this,Yt).notify({type:"observerRemoved",mutation:this,observer:s})}optionalRemove(){L(this,sl).length||(this.state.status==="pending"?this.scheduleGc():L(this,Yt).remove(this))}continue(){var s;return((s=L(this,cs))==null?void 0:s.continue())??(this.state.status==="pending"?this.execute(this.state.variables):Promise.resolve())}async execute(s){var m,p,y,x,v,b,w,C,N,M,R,j,F,T,H,D,z,Y;const i=()=>{De(this,il,oa).call(this,{type:"continue"})},r={client:L(this,Qr),meta:this.options.meta,mutationKey:this.options.mutationKey},u=oe(this,cs,l1({fn:()=>this.options.mutationFn?this.options.mutationFn(s,r):Promise.reject(new Error("No mutationFn 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50
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  * @remix-run/router v1.23.4
51
51
  *
52
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  * Copyright (c) Remix Software Inc.
@@ -55,7 +55,7 @@ Error generating stack: `+a.message+`
55
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  * LICENSE.md file in the root directory of this source tree.
56
56
  *
57
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  * @license MIT
58
- */function go(){return go=Object.assign?Object.assign.bind():function(n){for(var i=1;i<arguments.length;i++){var s=arguments[i];for(var o in s)({}).hasOwnProperty.call(s,o)&&(n[o]=s[o])}return n},go.apply(null,arguments)}var Zl;(function(n){n.Pop="POP",n.Push="PUSH",n.Replace="REPLACE"})(Zl||(Zl={}));const m0="popstate";function S2(n){n===void 0&&(n={});function i(o,u){let{pathname:f,search:d,hash:g}=o.location;return Xd("",{pathname:f,search:d,hash:g},u.state&&u.state.usr||null,u.state&&u.state.key||"default")}function s(o,u){return typeof u=="string"?u:vu(u)}return b2(i,s,null,n)}function rt(n,i){if(n===!1||n===null||typeof n>"u")throw new Error(i)}function Cy(n,i){if(!n){typeof console<"u"&&console.warn(i);try{throw new Error(i)}catch{}}}function x2(){return Math.random().toString(36).substr(2,8)}function g0(n,i){return{usr:n.state,key:n.key,idx:i}}function Xd(n,i,s,o){return s===void 0&&(s=null),go({pathname:typeof n=="string"?n:n.pathname,search:"",hash:""},typeof i=="string"?ns(i):i,{state:s,key:i&&i.key||o||x2()})}function vu(n){let{pathname:i="/",search:s="",hash:o=""}=n;return s&&s!=="?"&&(i+=s.charAt(0)==="?"?s:"?"+s),o&&o!=="#"&&(i+=o.charAt(0)==="#"?o:"#"+o),i}function ns(n){let i={};if(n){let s=n.indexOf("#");s>=0&&(i.hash=n.substr(s),n=n.substr(0,s));let o=n.indexOf("?");o>=0&&(i.search=n.substr(o),n=n.substr(0,o)),n&&(i.pathname=n)}return i}function b2(n,i,s,o){o===void 0&&(o={});let{window:u=document.defaultView,v5Compat:f=!1}=o,d=u.history,g=Zl.Pop,p=null,S=y();S==null&&(S=0,d.replaceState(go({},d.state,{idx:S}),""));function y(){return(d.state||{idx:null}).idx}function v(){g=Zl.Pop;let _=y(),w=_==null?null:_-S;S=_,p&&p({action:g,location:N.location,delta:w})}function b(_,w){g=Zl.Push;let j=Xd(N.location,_,w);S=y()+1;let O=g0(j,S),G=N.createHref(j);try{d.pushState(O,"",G)}catch(B){if(B instanceof DOMException&&B.name==="DataCloneError")throw B;u.location.assign(G)}f&&p&&p({action:g,location:N.location,delta:1})}function C(_,w){g=Zl.Replace;let j=Xd(N.location,_,w);S=y();let O=g0(j,S),G=N.createHref(j);d.replaceState(O,"",G),f&&p&&p({action:g,location:N.location,delta:0})}function E(_){let w=u.location.origin!=="null"?u.location.origin:u.location.href,j=typeof _=="string"?_:vu(_);return j=j.replace(/ $/,"%20"),rt(w,"No window.location.(origin|href) available to create URL for href: "+j),new URL(j,w)}let N={get action(){return g},get location(){return n(u,d)},listen(_){if(p)throw new Error("A history only accepts one active listener");return u.addEventListener(m0,v),p=_,()=>{u.removeEventListener(m0,v),p=null}},createHref(_){return i(u,_)},createURL:E,encodeLocation(_){let w=E(_);return{pathname:w.pathname,search:w.search,hash:w.hash}},push:b,replace:C,go(_){return d.go(_)}};return N}var p0;(function(n){n.data="data",n.deferred="deferred",n.redirect="redirect",n.error="error"})(p0||(p0={}));function C2(n,i,s){return s===void 0&&(s="/"),E2(n,i,s)}function E2(n,i,s,o){let u=typeof i=="string"?ns(i):i,f=xh(u.pathname||"/",s);if(f==null)return null;let d=Ey(n);w2(d);let g=null,p=H2(f);for(let S=0;g==null&&S<d.length;++S)g=z2(d[S],p);return g}function Ey(n,i,s,o){i===void 0&&(i=[]),s===void 0&&(s=[]),o===void 0&&(o="");let u=(f,d,g)=>{let p={relativePath:g===void 0?f.path||"":g,caseSensitive:f.caseSensitive===!0,childrenIndex:d,route:f};p.relativePath.startsWith("/")&&(rt(p.relativePath.startsWith(o),'Absolute route path "'+p.relativePath+'" nested under path '+('"'+o+'" is not valid. 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58
+ */function Vr(){return Vr=Object.assign?Object.assign.bind():function(n){for(var s=1;s<arguments.length;s++){var i=arguments[s];for(var r in i)({}).hasOwnProperty.call(i,r)&&(n[r]=i[r])}return n},Vr.apply(null,arguments)}var xa;(function(n){n.Pop="POP",n.Push="PUSH",n.Replace="REPLACE"})(xa||(xa={}));const Zv="popstate";function nw(n){n===void 0&&(n={});function s(r,u){let{pathname:d,search:h,hash:m}=r.location;return Nh("",{pathname:d,search:h,hash:m},u.state&&u.state.usr||null,u.state&&u.state.key||"default")}function i(r,u){return typeof u=="string"?u:f1(u)}return aw(s,i,null,n)}function wt(n,s){if(n===!1||n===null||typeof n>"u")throw new Error(s)}function c1(n,s){if(!n){typeof console<"u"&&console.warn(s);try{throw new Error(s)}catch{}}}function lw(){return Math.random().toString(36).substr(2,8)}function Pv(n,s){return{usr:n.state,key:n.key,idx:s}}function Nh(n,s,i,r){return i===void 0&&(i=null),Vr({pathname:typeof n=="string"?n:n.pathname,search:"",hash:""},typeof s=="string"?_i(s):s,{state:i,key:s&&s.key||r||lw()})}function f1(n){let{pathname:s="/",search:i="",hash:r=""}=n;return i&&i!=="?"&&(s+=i.charAt(0)==="?"?i:"?"+i),r&&r!=="#"&&(s+=r.charAt(0)==="#"?r:"#"+r),s}function _i(n){let s={};if(n){let i=n.indexOf("#");i>=0&&(s.hash=n.substr(i),n=n.substr(0,i));let r=n.indexOf("?");r>=0&&(s.search=n.substr(r),n=n.substr(0,r)),n&&(s.pathname=n)}return s}function aw(n,s,i,r){r===void 0&&(r={});let{window:u=document.defaultView,v5Compat:d=!1}=r,h=u.history,m=xa.Pop,p=null,y=x();y==null&&(y=0,h.replaceState(Vr({},h.state,{idx:y}),""));function x(){return(h.state||{idx:null}).idx}function v(){m=xa.Pop;let M=x(),R=M==null?null:M-y;y=M,p&&p({action:m,location:N.location,delta:R})}function b(M,R){m=xa.Push;let j=Nh(N.location,M,R);y=x()+1;let F=Pv(j,y),T=N.createHref(j);try{h.pushState(F,"",T)}catch(H){if(H instanceof DOMException&&H.name==="DataCloneError")throw H;u.location.assign(T)}d&&p&&p({action:m,location:N.location,delta:1})}function w(M,R){m=xa.Replace;let j=Nh(N.location,M,R);y=x();let F=Pv(j,y),T=N.createHref(j);h.replaceState(F,"",T),d&&p&&p({action:m,location:N.location,delta:0})}function C(M){let R=u.location.origin!=="null"?u.location.origin:u.location.href,j=typeof M=="string"?M:f1(M);return j=j.replace(/ $/,"%20"),wt(R,"No window.location.(origin|href) available to create URL for href: "+j),new URL(j,R)}let N={get action(){return m},get location(){return n(u,h)},listen(M){if(p)throw new Error("A history only accepts one active listener");return u.addEventListener(Zv,v),p=M,()=>{u.removeEventListener(Zv,v),p=null}},createHref(M){return s(u,M)},createURL:C,encodeLocation(M){let R=C(M);return{pathname:R.pathname,search:R.search,hash:R.hash}},push:b,replace:w,go(M){return h.go(M)}};return N}var Jv;(function(n){n.data="data",n.deferred="deferred",n.redirect="redirect",n.error="error"})(Jv||(Jv={}));function sw(n,s,i){return i===void 0&&(i="/"),iw(n,s,i)}function iw(n,s,i,r){let u=typeof s=="string"?_i(s):s,d=p1(u.pathname||"/",i);if(d==null)return null;let h=d1(n);rw(h);let m=null,p=g1(d);for(let y=0;m==null&&y<h.length;++y)m=pw(h[y],p);return m}function d1(n,s,i,r){s===void 0&&(s=[]),i===void 0&&(i=[]),r===void 0&&(r="");let u=(d,h,m)=>{let p={relativePath:m===void 0?d.path||"":m,caseSensitive:d.caseSensitive===!0,childrenIndex:h,route:d};p.relativePath.startsWith("/")&&(wt(p.relativePath.startsWith(r),'Absolute route path "'+p.relativePath+'" nested under path '+('"'+r+'" is not valid. 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59
59
  * React Router v6.30.6
60
60
  *
61
61
  * Copyright (c) Remix Software Inc.
@@ -64,7 +64,7 @@ Error generating stack: `+a.message+`
64
64
  * LICENSE.md file in the root directory of this source tree.
65
65
  *
66
66
  * @license MIT
67
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- */const Oe=(n,i)=>{const s=T.forwardRef(({className:o,...u},f)=>T.createElement(RC,{ref:f,iconNode:i,className:Hy(`lucide-${wC(n)}`,o),...u}));return s.displayName=`${n}`,s};/**
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+ */const Ue=(n,s)=>{const i=E.forwardRef(({className:r,...u},d)=>E.createElement(tC,{ref:d,iconNode:s,className:E1(`lucide-${Ww(n)}`,r),...u}));return i.displayName=`${n}`,i};/**
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
101
- */const TC=Oe("Activity",[["path",{d:"M22 12h-2.48a2 2 0 0 0-1.93 1.46l-2.35 8.36a.25.25 0 0 1-.48 0L9.24 2.18a.25.25 0 0 0-.48 0l-2.35 8.36A2 2 0 0 1 4.49 12H2",key:"169zse"}]]);/**
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+ */const nC=Ue("Activity",[["path",{d:"M22 12h-2.48a2 2 0 0 0-1.93 1.46l-2.35 8.36a.25.25 0 0 1-.48 0L9.24 2.18a.25.25 0 0 0-.48 0l-2.35 8.36A2 2 0 0 1 4.49 12H2",key:"169zse"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
106
- */const yu=Oe("ArrowDown",[["path",{d:"M12 5v14",key:"s699le"}],["path",{d:"m19 12-7 7-7-7",key:"1idqje"}]]);/**
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+ */const zu=Ue("ArrowDown",[["path",{d:"M12 5v14",key:"s699le"}],["path",{d:"m19 12-7 7-7-7",key:"1idqje"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const NC=Oe("ArrowUpRight",[["path",{d:"M7 7h10v10",key:"1tivn9"}],["path",{d:"M7 17 17 7",key:"1vkiza"}]]);/**
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+ */const lC=Ue("ArrowUpRight",[["path",{d:"M7 7h10v10",key:"1tivn9"}],["path",{d:"M7 17 17 7",key:"1vkiza"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
116
- */const Ly=Oe("ArrowUp",[["path",{d:"m5 12 7-7 7 7",key:"hav0vg"}],["path",{d:"M12 19V5",key:"x0mq9r"}]]);/**
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+ */const N1=Ue("ArrowUp",[["path",{d:"m5 12 7-7 7 7",key:"hav0vg"}],["path",{d:"M12 19V5",key:"x0mq9r"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
121
- */const MC=Oe("AudioWaveform",[["path",{d:"M2 13a2 2 0 0 0 2-2V7a2 2 0 0 1 4 0v13a2 2 0 0 0 4 0V4a2 2 0 0 1 4 0v13a2 2 0 0 0 4 0v-4a2 2 0 0 1 2-2",key:"57tc96"}]]);/**
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+ */const aC=Ue("AudioWaveform",[["path",{d:"M2 13a2 2 0 0 0 2-2V7a2 2 0 0 1 4 0v13a2 2 0 0 0 4 0V4a2 2 0 0 1 4 0v13a2 2 0 0 0 4 0v-4a2 2 0 0 1 2-2",key:"57tc96"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
126
- */const jC=Oe("ChartPie",[["path",{d:"M21 12c.552 0 1.005-.449.95-.998a10 10 0 0 0-8.953-8.951c-.55-.055-.998.398-.998.95v8a1 1 0 0 0 1 1z",key:"pzmjnu"}],["path",{d:"M21.21 15.89A10 10 0 1 1 8 2.83",key:"k2fpak"}]]);/**
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+ */const sC=Ue("ChartPie",[["path",{d:"M21 12c.552 0 1.005-.449.95-.998a10 10 0 0 0-8.953-8.951c-.55-.055-.998.398-.998.95v8a1 1 0 0 0 1 1z",key:"pzmjnu"}],["path",{d:"M21.21 15.89A10 10 0 1 1 8 2.83",key:"k2fpak"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
131
- */const AC=Oe("Check",[["path",{d:"M20 6 9 17l-5-5",key:"1gmf2c"}]]);/**
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+ */const _1=Ue("Check",[["path",{d:"M20 6 9 17l-5-5",key:"1gmf2c"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
136
- */const Ch=Oe("ChevronRight",[["path",{d:"m9 18 6-6-6-6",key:"mthhwq"}]]);/**
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+ */const M1=Ue("ChevronDown",[["path",{d:"m6 9 6 6 6-6",key:"qrunsl"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
141
- */const OC=Oe("CircleAlert",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"12",x2:"12",y1:"8",y2:"12",key:"1pkeuh"}],["line",{x1:"12",x2:"12.01",y1:"16",y2:"16",key:"4dfq90"}]]);/**
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+ */const nm=Ue("ChevronRight",[["path",{d:"m9 18 6-6-6-6",key:"mthhwq"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const zC=Oe("CircleCheck",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"m9 12 2 2 4-4",key:"dzmm74"}]]);/**
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+ */const iC=Ue("CircleAlert",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"12",x2:"12",y1:"8",y2:"12",key:"1pkeuh"}],["line",{x1:"12",x2:"12.01",y1:"16",y2:"16",key:"4dfq90"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const DC=Oe("CircleDashed",[["path",{d:"M10.1 2.182a10 10 0 0 1 3.8 0",key:"5ilxe3"}],["path",{d:"M13.9 21.818a10 10 0 0 1-3.8 0",key:"11zvb9"}],["path",{d:"M17.609 3.721a10 10 0 0 1 2.69 2.7",key:"1iw5b2"}],["path",{d:"M2.182 13.9a10 10 0 0 1 0-3.8",key:"c0bmvh"}],["path",{d:"M20.279 17.609a10 10 0 0 1-2.7 2.69",key:"1ruxm7"}],["path",{d:"M21.818 10.1a10 10 0 0 1 0 3.8",key:"qkgqxc"}],["path",{d:"M3.721 6.391a10 10 0 0 1 2.7-2.69",key:"1mcia2"}],["path",{d:"M6.391 20.279a10 10 0 0 1-2.69-2.7",key:"1fvljs"}]]);/**
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+ */const rC=Ue("CircleCheck",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"m9 12 2 2 4-4",key:"dzmm74"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const Vy=Oe("Copy",[["rect",{width:"14",height:"14",x:"8",y:"8",rx:"2",ry:"2",key:"17jyea"}],["path",{d:"M4 16c-1.1 0-2-.9-2-2V4c0-1.1.9-2 2-2h10c1.1 0 2 .9 2 2",key:"zix9uf"}]]);/**
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+ */const oC=Ue("CircleDashed",[["path",{d:"M10.1 2.182a10 10 0 0 1 3.8 0",key:"5ilxe3"}],["path",{d:"M13.9 21.818a10 10 0 0 1-3.8 0",key:"11zvb9"}],["path",{d:"M17.609 3.721a10 10 0 0 1 2.69 2.7",key:"1iw5b2"}],["path",{d:"M2.182 13.9a10 10 0 0 1 0-3.8",key:"c0bmvh"}],["path",{d:"M20.279 17.609a10 10 0 0 1-2.7 2.69",key:"1ruxm7"}],["path",{d:"M21.818 10.1a10 10 0 0 1 0 3.8",key:"qkgqxc"}],["path",{d:"M3.721 6.391a10 10 0 0 1 2.7-2.69",key:"1mcia2"}],["path",{d:"M6.391 20.279a10 10 0 0 1-2.69-2.7",key:"1fvljs"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
161
- */const UC=Oe("CornerDownLeft",[["polyline",{points:"9 10 4 15 9 20",key:"r3jprv"}],["path",{d:"M20 4v7a4 4 0 0 1-4 4H4",key:"6o5b7l"}]]);/**
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+ */const R1=Ue("Copy",[["rect",{width:"14",height:"14",x:"8",y:"8",rx:"2",ry:"2",key:"17jyea"}],["path",{d:"M4 16c-1.1 0-2-.9-2-2V4c0-1.1.9-2 2-2h10c1.1 0 2 .9 2 2",key:"zix9uf"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
166
- */const eh=Oe("Crosshair",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"22",x2:"18",y1:"12",y2:"12",key:"l9bcsi"}],["line",{x1:"6",x2:"2",y1:"12",y2:"12",key:"13hhkx"}],["line",{x1:"12",x2:"12",y1:"6",y2:"2",key:"10w3f3"}],["line",{x1:"12",x2:"12",y1:"22",y2:"18",key:"15g9kq"}]]);/**
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+ */const Ah=Ue("Crosshair",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"22",x2:"18",y1:"12",y2:"12",key:"l9bcsi"}],["line",{x1:"6",x2:"2",y1:"12",y2:"12",key:"13hhkx"}],["line",{x1:"12",x2:"12",y1:"6",y2:"2",key:"10w3f3"}],["line",{x1:"12",x2:"12",y1:"22",y2:"18",key:"15g9kq"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
171
- */const Tu=Oe("Dna",[["path",{d:"m10 16 1.5 1.5",key:"11lckj"}],["path",{d:"m14 8-1.5-1.5",key:"1ohn8i"}],["path",{d:"M15 2c-1.798 1.998-2.518 3.995-2.807 5.993",key:"80uv8i"}],["path",{d:"m16.5 10.5 1 1",key:"696xn5"}],["path",{d:"m17 6-2.891-2.891",key:"xu6p2f"}],["path",{d:"M2 15c6.667-6 13.333 0 20-6",key:"1pyr53"}],["path",{d:"m20 9 .891.891",key:"3xwk7g"}],["path",{d:"M3.109 14.109 4 15",key:"q76aoh"}],["path",{d:"m6.5 12.5 1 1",key:"cs35ky"}],["path",{d:"m7 18 2.891 2.891",key:"1sisit"}],["path",{d:"M9 22c1.798-1.998 2.518-3.995 2.807-5.993",key:"q3hbxp"}]]);/**
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+ */const qu=Ue("Dna",[["path",{d:"m10 16 1.5 1.5",key:"11lckj"}],["path",{d:"m14 8-1.5-1.5",key:"1ohn8i"}],["path",{d:"M15 2c-1.798 1.998-2.518 3.995-2.807 5.993",key:"80uv8i"}],["path",{d:"m16.5 10.5 1 1",key:"696xn5"}],["path",{d:"m17 6-2.891-2.891",key:"xu6p2f"}],["path",{d:"M2 15c6.667-6 13.333 0 20-6",key:"1pyr53"}],["path",{d:"m20 9 .891.891",key:"3xwk7g"}],["path",{d:"M3.109 14.109 4 15",key:"q76aoh"}],["path",{d:"m6.5 12.5 1 1",key:"cs35ky"}],["path",{d:"m7 18 2.891 2.891",key:"1sisit"}],["path",{d:"M9 22c1.798-1.998 2.518-3.995 2.807-5.993",key:"q3hbxp"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
175
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  * See the LICENSE file in the root directory of this source tree.
176
- */const HC=Oe("Download",[["path",{d:"M21 15v4a2 2 0 0 1-2 2H5a2 2 0 0 1-2-2v-4",key:"ih7n3h"}],["polyline",{points:"7 10 12 15 17 10",key:"2ggqvy"}],["line",{x1:"12",x2:"12",y1:"15",y2:"3",key:"1vk2je"}]]);/**
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+ */const T1=Ue("FlaskConical",[["path",{d:"M14 2v6a2 2 0 0 0 .245.96l5.51 10.08A2 2 0 0 1 18 22H6a2 2 0 0 1-1.755-2.96l5.51-10.08A2 2 0 0 0 10 8V2",key:"18mbvz"}],["path",{d:"M6.453 15h11.094",key:"3shlmq"}],["path",{d:"M8.5 2h7",key:"csnxdl"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
181
- */const Fy=Oe("FlaskConical",[["path",{d:"M14 2v6a2 2 0 0 0 .245.96l5.51 10.08A2 2 0 0 1 18 22H6a2 2 0 0 1-1.755-2.96l5.51-10.08A2 2 0 0 0 10 8V2",key:"18mbvz"}],["path",{d:"M6.453 15h11.094",key:"3shlmq"}],["path",{d:"M8.5 2h7",key:"csnxdl"}]]);/**
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+ */const uC=Ue("FolderOpen",[["path",{d:"m6 14 1.5-2.9A2 2 0 0 1 9.24 10H20a2 2 0 0 1 1.94 2.5l-1.54 6a2 2 0 0 1-1.95 1.5H4a2 2 0 0 1-2-2V5a2 2 0 0 1 2-2h3.9a2 2 0 0 1 1.69.9l.81 1.2a2 2 0 0 0 1.67.9H18a2 2 0 0 1 2 2v2",key:"usdka0"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
186
- */const LC=Oe("History",[["path",{d:"M3 12a9 9 0 1 0 9-9 9.75 9.75 0 0 0-6.74 2.74L3 8",key:"1357e3"}],["path",{d:"M3 3v5h5",key:"1xhq8a"}],["path",{d:"M12 7v5l4 2",key:"1fdv2h"}]]);/**
186
+ */const cC=Ue("Info",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"M12 16v-4",key:"1dtifu"}],["path",{d:"M12 8h.01",key:"e9boi3"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
188
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  *
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  * This source code is licensed under the ISC license.
190
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  * See the LICENSE file in the root directory of this source tree.
191
- */const VC=Oe("Info",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"M12 16v-4",key:"1dtifu"}],["path",{d:"M12 8h.01",key:"e9boi3"}]]);/**
191
+ */const fC=Ue("LayoutGrid",[["rect",{width:"7",height:"7",x:"3",y:"3",rx:"1",key:"1g98yp"}],["rect",{width:"7",height:"7",x:"14",y:"3",rx:"1",key:"6d4xhi"}],["rect",{width:"7",height:"7",x:"14",y:"14",rx:"1",key:"nxv5o0"}],["rect",{width:"7",height:"7",x:"3",y:"14",rx:"1",key:"1bb6yr"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
195
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  * See the LICENSE file in the root directory of this source tree.
196
- */const FC=Oe("LayoutGrid",[["rect",{width:"7",height:"7",x:"3",y:"3",rx:"1",key:"1g98yp"}],["rect",{width:"7",height:"7",x:"14",y:"3",rx:"1",key:"6d4xhi"}],["rect",{width:"7",height:"7",x:"14",y:"14",rx:"1",key:"nxv5o0"}],["rect",{width:"7",height:"7",x:"3",y:"14",rx:"1",key:"1bb6yr"}]]);/**
196
+ */const dC=Ue("Link2",[["path",{d:"M9 17H7A5 5 0 0 1 7 7h2",key:"8i5ue5"}],["path",{d:"M15 7h2a5 5 0 1 1 0 10h-2",key:"1b9ql8"}],["line",{x1:"8",x2:"16",y1:"12",y2:"12",key:"1jonct"}]]);/**
197
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
200
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  * See the LICENSE file in the root directory of this source tree.
201
- */const BC=Oe("Link2",[["path",{d:"M9 17H7A5 5 0 0 1 7 7h2",key:"8i5ue5"}],["path",{d:"M15 7h2a5 5 0 1 1 0 10h-2",key:"1b9ql8"}],["line",{x1:"8",x2:"16",y1:"12",y2:"12",key:"1jonct"}]]);/**
201
+ */const hC=Ue("Maximize2",[["polyline",{points:"15 3 21 3 21 9",key:"mznyad"}],["polyline",{points:"9 21 3 21 3 15",key:"1avn1i"}],["line",{x1:"21",x2:"14",y1:"3",y2:"10",key:"ota7mn"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
202
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  * @license lucide-react v0.468.0 - ISC
203
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  *
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  * This source code is licensed under the ISC license.
205
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  * See the LICENSE file in the root directory of this source tree.
206
- */const GC=Oe("Maximize2",[["polyline",{points:"15 3 21 3 21 9",key:"mznyad"}],["polyline",{points:"9 21 3 21 3 15",key:"1avn1i"}],["line",{x1:"21",x2:"14",y1:"3",y2:"10",key:"ota7mn"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
206
+ */const mC=Ue("Microscope",[["path",{d:"M6 18h8",key:"1borvv"}],["path",{d:"M3 22h18",key:"8prr45"}],["path",{d:"M14 22a7 7 0 1 0 0-14h-1",key:"1jwaiy"}],["path",{d:"M9 14h2",key:"197e7h"}],["path",{d:"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z",key:"1bmzmy"}],["path",{d:"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3",key:"1drr47"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
210
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  * See the LICENSE file in the root directory of this source tree.
211
- */const qC=Oe("Microscope",[["path",{d:"M6 18h8",key:"1borvv"}],["path",{d:"M3 22h18",key:"8prr45"}],["path",{d:"M14 22a7 7 0 1 0 0-14h-1",key:"1jwaiy"}],["path",{d:"M9 14h2",key:"197e7h"}],["path",{d:"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z",key:"1bmzmy"}],["path",{d:"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3",key:"1drr47"}]]);/**
211
+ */const gC=Ue("Minimize2",[["polyline",{points:"4 14 10 14 10 20",key:"11kfnr"}],["polyline",{points:"20 10 14 10 14 4",key:"rlmsce"}],["line",{x1:"14",x2:"21",y1:"10",y2:"3",key:"o5lafz"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
215
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  * See the LICENSE file in the root directory of this source tree.
216
- */const kC=Oe("Minimize2",[["polyline",{points:"4 14 10 14 10 20",key:"11kfnr"}],["polyline",{points:"20 10 14 10 14 4",key:"rlmsce"}],["line",{x1:"14",x2:"21",y1:"10",y2:"3",key:"o5lafz"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
216
+ */const pC=Ue("PanelLeftClose",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m16 15-3-3 3-3",key:"14y99z"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
220
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  * See the LICENSE file in the root directory of this source tree.
221
- */const Nu=Oe("Search",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["path",{d:"m21 21-4.3-4.3",key:"1qie3q"}]]);/**
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+ */const vC=Ue("PanelLeftOpen",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m14 9 3 3-3 3",key:"8010ee"}]]);/**
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- */const $C=Oe("Shield",[["path",{d:"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z",key:"oel41y"}]]);/**
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+ */const Du=Ue("Search",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["path",{d:"m21 21-4.3-4.3",key:"1qie3q"}]]);/**
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- */const QC=Oe("Shuffle",[["path",{d:"m18 14 4 4-4 4",key:"10pe0f"}],["path",{d:"m18 2 4 4-4 4",key:"pucp1d"}],["path",{d:"M2 18h1.973a4 4 0 0 0 3.3-1.7l5.454-8.6a4 4 0 0 1 3.3-1.7H22",key:"1ailkh"}],["path",{d:"M2 6h1.972a4 4 0 0 1 3.6 2.2",key:"km57vx"}],["path",{d:"M22 18h-6.041a4 4 0 0 1-3.3-1.8l-.359-.45",key:"os18l9"}]]);/**
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+ */const yC=Ue("Shield",[["path",{d:"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z",key:"oel41y"}]]);/**
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- */const By=Oe("TriangleAlert",[["path",{d:"m21.73 18-8-14a2 2 0 0 0-3.48 0l-8 14A2 2 0 0 0 4 21h16a2 2 0 0 0 1.73-3",key:"wmoenq"}],["path",{d:"M12 9v4",key:"juzpu7"}],["path",{d:"M12 17h.01",key:"p32p05"}]]);/**
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+ */const xC=Ue("Shuffle",[["path",{d:"m18 14 4 4-4 4",key:"10pe0f"}],["path",{d:"m18 2 4 4-4 4",key:"pucp1d"}],["path",{d:"M2 18h1.973a4 4 0 0 0 3.3-1.7l5.454-8.6a4 4 0 0 1 3.3-1.7H22",key:"1ailkh"}],["path",{d:"M2 6h1.972a4 4 0 0 1 3.6 2.2",key:"km57vx"}],["path",{d:"M22 18h-6.041a4 4 0 0 1-3.3-1.8l-.359-.45",key:"os18l9"}]]);/**
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  *
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- */const Gy=Oe("UserRound",[["circle",{cx:"12",cy:"8",r:"5",key:"1hypcn"}],["path",{d:"M20 21a8 8 0 0 0-16 0",key:"rfgkzh"}]]);/**
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+ */const A1=Ue("TriangleAlert",[["path",{d:"m21.73 18-8-14a2 2 0 0 0-3.48 0l-8 14A2 2 0 0 0 4 21h16a2 2 0 0 0 1.73-3",key:"wmoenq"}],["path",{d:"M12 9v4",key:"juzpu7"}],["path",{d:"M12 17h.01",key:"p32p05"}]]);/**
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  *
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  * See the LICENSE file in the root directory of this source tree.
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- */const YC=Oe("Waves",[["path",{d:"M2 6c.6.5 1.2 1 2.5 1C7 7 7 5 9.5 5c2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"knzxuh"}],["path",{d:"M2 12c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"2jd2cc"}],["path",{d:"M2 18c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"rd2r6e"}]]);/**
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+ */const SC=Ue("UserRound",[["circle",{cx:"12",cy:"8",r:"5",key:"1hypcn"}],["path",{d:"M20 21a8 8 0 0 0-16 0",key:"rfgkzh"}]]);/**
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  *
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- */const Eh=Oe("X",[["path",{d:"M18 6 6 18",key:"1bl5f8"}],["path",{d:"m6 6 12 12",key:"d8bk6v"}]]);/**
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+ */const bC=Ue("Users",[["path",{d:"M16 21v-2a4 4 0 0 0-4-4H6a4 4 0 0 0-4 4v2",key:"1yyitq"}],["circle",{cx:"9",cy:"7",r:"4",key:"nufk8"}],["path",{d:"M22 21v-2a4 4 0 0 0-3-3.87",key:"kshegd"}],["path",{d:"M16 3.13a4 4 0 0 1 0 7.75",key:"1da9ce"}]]);/**
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- */const IC=Oe("ZoomOut",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["line",{x1:"21",x2:"16.65",y1:"21",y2:"16.65",key:"13gj7c"}],["line",{x1:"8",x2:"14",y1:"11",y2:"11",key:"durymu"}]]);function XC(n){if(n.value===null)return n.text??"";switch(n.key){case"coverage":return`${Math.round(n.value)}×`;case"tmb":return n.value<.01?n.value.toPrecision(2):n.value.toFixed(2);default:return n.value.toFixed(2)}}function KC(n){return n.status==="failed"?"Failed":n.status==="skipped"?"Not in this mode":"Not run"}const ZC=new Intl.DateTimeFormat("en-GB",{day:"numeric",month:"short",year:"numeric"});function PC(n){if(!n)return"";const i=new Date(n);return Number.isNaN(i.getTime())?"":ZC.format(i)}function wh(n,i){return n.startsWith(`${i}_`)?n.slice(i.length+1):n}function th(n){return n==null?"–":n.toFixed(2)}const E0={missense_variant:"Missense",stop_gained:"Nonsense",stop_lost:"Stop lost",start_lost:"Start lost",frameshift_variant:"Frameshift",inframe_deletion:"In-frame 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aE={"DNA|WG":{label:"WGS",icon:Tu},"RNA|WT":{label:"RNA",icon:MC}};function M0({children:n}){return h.jsx("svg",{width:"17",height:"17",viewBox:"0 0 24 24",fill:"none",stroke:"currentColor",strokeWidth:"2",strokeLinecap:"round",strokeLinejoin:"round","aria-hidden":!0,children:n})}function iE({sex:n}){const i=n==null?void 0:n.toUpperCase();return i==="MALE"?h.jsxs(M0,{children:[h.jsx("circle",{cx:"12",cy:"9",r:"4.5"}),h.jsx("path",{d:"M7.6 8.2c.5-2.9 2.4-4.7 4.6-4.7 2.6 0 4.4 1.7 4.4 4.3-2.2.1-4.2-.6-5.6-2.1"}),h.jsx("path",{d:"M3.5 21a8.5 7.5 0 0 1 17 0"}),h.jsx("path",{d:"m10 15.6 2 2.2 2-2.2"})]}):i==="FEMALE"?h.jsxs(M0,{children:[h.jsx("circle",{cx:"12",cy:"9.2",r:"3.4"}),h.jsx("path",{d:"M6.3 14.2C4.6 9 6.6 2.8 12 2.8s7.4 6.2 5.7 11.4"}),h.jsx("path",{d:"M5 21.2a7 6.3 0 0 1 14 0"})]}):h.jsx(Gy,{size:16,"aria-hidden":!0})}const ky="wgts-patient-root";function sE(n,i){const s=n.getBoundingClientRect(),o=n.closest(".topbar"),u=o==null?void 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Chromosome 1 starts at the top and the ring runs clockwise through chromosome 22 to X, each chromosome's arc in proportion to its length (GRCh37).","Copy-number changes are called against the tumour's baseline, its ploidy rounded to whole copies. Very short changes are drawn at a minimum length so they stay visible."],terms:[["Gains (outer track, orange)","Regions with at least one copy more than the baseline."],["Amplifications (outer track, darker and thicker)","Regions with three or more copies above the baseline."],["Losses (inner track, blue)","Regions with at least one copy fewer than the baseline."],["Drivers (black ticks)","Where the tumour's likely driver mutations sit (see the Mutations card for how they are flagged)."]]},{heading:"The sentence",paragraphs:["Written from the same data as the ring: how many amplifications, gains and losses there are and on which chromosomes, and which genes carry driver mutations."]},{heading:"The measurements",paragraphs:["Each tile shows a value, a small picture of where it sits on its scale when it has a natural one, and the analysis it came from. A tile with no value says why: the analysis was not run, it failed, or it does not apply to this kind of report (tumour-only reports have no matched normal)."],terms:[["Purity","The estimated fraction of cells in the sample that are tumour cells, from 0 to 1. The ring fills to the value."],["Ploidy","The tumour's average number of copies across the genome. The scale runs from 1 to 6 copies; the tall tick marks 2, a diploid genome."],["Coverage","The median sequencing depth of the tumour across the genome, in reads (×)."],["TMB per Mb","Tumour mutational burden: somatic SNVs and indels per megabase of genome. The report computes it from the counts of the SNV and indel calls. The scale is logarithmic, 0.01 to 100."],["MSI score","The MSIsensor score: the percentage of microsatellite sites that look unstable in the tumour."],["FGA","Fraction of the genome altered: the share of the genome whose copy number differs from the baseline, from 0 to 1. It is read from the project-wide Battenberg tables."]]},{heading:"Linking back to the analyses",paragraphs:[`Every value names its analysis, with version and Isabl id. Picking an analysis in the side menu's "Analyses on this page" highlights the tiles and cards it feeds.`]}]},copyNumber:{title:"Copy number",intro:"How many copies of each part of the genome the tumour carries, segment by segment, from chromosome 1 to X.",sections:[{heading:"What is drawn",paragraphs:['Each horizontal stroke is one segment: a stretch of the genome with a constant copy number. Its height is the number of copies, from 0 up to 8; anything higher is drawn at the top and the axis reads "8+". Alternating grey bands mark the chromosomes, named along the bottom.',`The dashed line is the baseline: the tumour's ploidy rounded to whole copies (labelled, for example, "2 copies"). Segments are coloured by how they compare with it.`],terms:[["Grey","Neutral: the same number of copies as the baseline."],["Orange","Gain: at least one copy more than the baseline."],["Dark orange","Amplification: three or more copies above the baseline."],["Blue","Loss: at least one copy fewer than the baseline."]]},{heading:"Total or allele-specific",paragraphs:["Total shows all copies together. Allele-specific, when the analysis provides it, splits each segment into its major allele (the more common parental copy, dark) and minor allele (light). Where the two are equal they are drawn slightly apart so both stay visible. A minor allele of 0 means one parent's copy is lost there (loss of heterozygosity)."]},{heading:"Driver genes",paragraphs:["Triangles along the top mark the genes with likely driver mutations, one per gene; hover for its protein changes."]},{heading:"Reading and moving around",terms:[["Hover a segment","Its call, copies (major + minor), coordinates and, when available, log2 ratio."],["Click a segment","Lists the mutations inside it in the Mutations card."],["Click a driver","Finds that gene in the Mutations card."],["Pinch, or Ctrl and scroll","Zooms around the pointer. Plain scrolling always scrolls the page."],["Drag","Pans a zoomed view."],["Double-click a chromosome","Zooms to fill the view with it; the axis then counts megabases."],["Slider and reset","The slider under the plot shows and moves the window; the button by the title returns to the whole genome."],["Hover a mutation in the table","Marks it here, with a ring on the segment it sits on and its copy number."]]},{heading:"Tumour-only reports",paragraphs:["Without a matched normal there is no ploidy estimate, so segments come from CNVkit and are called against two copies. Allele-specific copy numbers are not available."]}]},mutations:{title:"Mutations",intro:"The tumour's somatic SNVs and indels that passed the callers' filters: how they are distributed across cancer cells, and a searchable, filterable table of every call.",sections:[{heading:"Which mutations",terms:[["Drivers","Likely drivers flagged by the report: coding mutations that match OncoKB or COSMIC driver annotations (the exact protein change, or a damaging consequence in a known cancer gene), plus known hotspots the callers missed and the report recovered from the tumour's reads."],["Coding","Mutations whose effect changes a protein, by the report's list of coding effects."],["All","Every PASS SNV and indel."]],paragraphs:["The counts beside each choice follow the search and filters, so they always say what you would see."]},{heading:"FFPE samples",paragraphs:["Formalin-fixed (FFPE) tissue damages DNA in ways that look like mutations, mostly C>T changes at low allele fractions. For an FFPE sample, FFPERASE scores each SNV and indel for how likely it is to be such an artifact, and the report counts only the calls scored at or below its threshold (quoted beside the table). Its SNV, indel and coding totals and the TMB leave the rest out.",`The report marks each call it leaves out, and the dashboard follows that mark: the Coding and All counts, the table and the curve leave those calls out, and the card's subtitle says so. Drivers are all listed, as in the report, and any the filter would remove carry an "FFPE filtered" tag. "Show filtered calls", under FFPE filter beside the table, brings the removed calls back, tagged the same way.`]},{heading:"Cancer cell fraction and variant allele fraction",paragraphs:["The curve across the top is a smoothed histogram of every PASS mutation; driver mutations are labelled on it. Switch between the two measures:"],terms:[["CCF",'Cancer cell fraction: the estimated share of cancer cells carrying the mutation, corrected for purity and copy number. Around 1 (the "clonal" mark) means nearly every cancer cell has it, which suggests it arose early; clearly below 1 means a subclone. Estimates can land somewhat above 1. Shown from 0 to 2.'],["VAF","Variant allele fraction: the share of sequencing reads at the position that carry the mutation, from 0 to 1. Raw, not corrected for purity or copy number. Tumour-only reports open on VAF, since CCF needs a matched normal."]]},{heading:"Filtering by the curve",paragraphs:["Drag across the curve to keep only mutations in that CCF or VAF range; drivers outside it fade. The range appears with the other filters and can be removed there, or by clicking the curve."]},{heading:"The table",terms:[["Gene and position","The gene, and the mutation's chromosome and position (GRCh37)."],["Change","The protein change, with the cDNA change beneath."],["Effect","What the mutation does to the gene, from the VEP consequence (or the report's effect). Truncating effects are in bold."],["VAF and CCF bars","The value with a bar for quick comparison; the CCF bar's tick marks 1, clonal."],["Driver","Flagged as a likely driver (shown when the table is not already limited to drivers)."],["Hotspot","The exact protein change is a known recurrent cancer hotspot."],["In DMP","The same mutation was also found by the patient's clinical MSK-IMPACT (DMP) sequencing."],["FFPE filtered","FFPE samples only: the report's FFPE artifact filter leaves this call out of its counts (see FFPE samples)."]]},{heading:"Opening a row",terms:[["Variant","SNV or indel, with the reference and alternate bases."],["Reads","Reads supporting the mutation out of all reads at the position. Only hotspots the report recovered from the tumour's reads have them; the callers' tables give no single count."],["Normal VAF","The mutation's allele fraction in the matched normal; near 0 for a somatic mutation."],["Mutant copies","How many copies of that part of the genome carry the mutation, out of all copies there."],["Consequence","The full VEP consequence."],["COSMIC","How many samples in COSMIC carry it, and how closely they match (exact change, same position, codon or gene)."],["Expression","The gene's expression in the tumour's RNA, in transcripts per million, when RNA was sequenced."],["Gene role","Whether the gene is a known oncogene or tumour suppressor gene (TSG)."],["Show on copy number","Zooms the Copy number card to the mutation's chromosome and marks it."]]},{heading:"Searching and filtering",paragraphs:["Search takes a gene, a protein or cDNA change, a COSMIC term, or a locus such as chr12:25,398,284 or a range such as chr8:1-50,000,000. Press / anywhere on the page to jump to it. Each filter's count is how many rows you would get by ticking it, given everything else."],terms:[["Missense","One amino acid replaced by another."],["Truncating","Stop gained or lost, start lost, or a frameshift."],["Splice","Changes a splice site or splice region."],["In-frame","Inserts or deletes amino acids without shifting the reading frame."],["Synonymous","Changes the DNA but not the amino acid."],["Other","Everything else, such as intronic, UTR or upstream changes."]]}]},structuralVariants:{title:"Structural variants",intro:"The tumour's rearrangements as the report shows them: those with a breakpoint in an oncogene or tumour suppressor, those that take in a whole gene, and how all of them group into rearrangement signatures.",sections:[{heading:"Which rearrangements",paragraphs:["The report works from the high-confidence structural variants of ANNOT_SVS, which keeps calls made by two or more callers (SvABA, BRASS and GRIDSS) and annotates the genes they touch with AnnotSV. The count beside the title is how many of these the report counts, its rearrangements total.",`The tables keep the rearrangements whose genes include an oncogene or tumour suppressor, by the report's gene lists. It also searches the callers' raw calls for known rearrangements the high-confidence set can miss, such as CIC fusions, and adds them; a rescued event that is not a two-caller PASS says so in its callers, as in "gridss (CIC rescued)".`]},{heading:"The two tables",terms:[["Rearranged oncogenes and tumour suppressors",'One row per rearrangement and gene it hits, with the gene and breakpoint on each side. A gene near a breakpoint rather than in it is named as the report names it, such as "TERT +/- 100Kb".'],["Whole-gene rearrangements","Rearrangements that take in a whole oncogene or tumour suppressor, from start to end: a deletion of the whole gene, for example."],["Role","Whether the row's genes include an oncogene, a tumour suppressor or both, as the report colours its rows. Click a role above the tables to show only its rows."],["Left and right","Each breakpoint's gene, position (GRCh37) and where it falls in the gene, as AnnotSV writes it (intron5, exon2-exon5). Breakpoints are ordered by chromosome, then position."],["Callers and support","The callers that made the call, and the most reads any of them gives in support."],["Pileups","Supporting reads over all reads at each breakpoint in the tumour's alignments, left then right."],["Expression","For tumours with RNA: whether each gene's expression is high or low against each expression cohort (p63 is cohort project 63): at or above its 90th percentile, at or below its 10th, or neither (None). N/A means the cohort has no value for the gene."]],paragraphs:["Open a row to see both breakpoints, show them on the copy-number card, or copy their IGV loci."]},{heading:"Rearrangement signatures",paragraphs:["WGSPOST groups the tumour's rearrangements the way rearrangement signatures are described: clustered (rearrangements that sit unusually close together, as in chromothripsis) or dispersed, then by class and, except for translocations, by size from under 1 kb to over 1 Mb. Each bar is how many rearrangements fall in a group; lighter bars are the clustered ones.","WGSPOST counts from its own copy of the calls, so its total can differ slightly from the report's rearrangements count."],terms:[["Deletion","A stretch of the genome lost between two breakpoints."],["Tandem duplication","A stretch copied next to itself."],["Inversion","A stretch turned around in place."],["Translocation","A join between two chromosomes."]]}]},signaturesHrd:{title:"Signatures and HRD",intro:"Which mutational processes left their mark on the tumour, set against tumours of the same disease, and whether it shows homologous recombination deficiency (HRD), as the report shows them.",sections:[{heading:"Mutational signatures",paragraphs:["WGSPOST fits known COSMIC substitution signatures to the tumour's somatic SNVs and estimates how many mutations each one accounts for. The left column is this tumour: each band is a signature's share of its mutations, the largest first.","The right column is the average of tumours of the same disease in the cohort (n is how many), each tumour's shares averaged and scaled to the cohort's average mutation count. The bands join the two columns, so a signature can be followed from the tumour to its cohort. Hover a band or a row of the table for the numbers.","Eight signatures get colours of their own; any beyond that are drawn together as Other. A tumour without a cohort to compare shows its own shares as one bar."],terms:[["Signature","A pattern of substitutions, by the base change and its neighbours, that a mutational process leaves (SBS1, SBS5)."],["Aetiology","The process the report links a signature to, when it names one."]]},{heading:"HRD scores",paragraphs:["Two classifiers estimate whether the tumour has lost homologous recombination repair, as BRCA1 or BRCA2 loss does: HRDetect, from the substitution, indel and rearrangement patterns below, and CHORD, from its own set of mutation features. The report rates each HIGH at or above its threshold and LOW below it; the line on each gauge is the threshold."]},{heading:"HRDetect features",paragraphs:["The six features HRDetect weighs, for every tumour in the cohort and this one, each scaled from 0 (the cohort's lowest) to 1 (its highest). The box spans the middle half of the cohort, the line in it is the median, the whiskers reach the furthest tumours within one and a half box-lengths, and dots beyond them are outliers. The tumour is the marked point; hover it for its unscaled value. For FFPE samples the tumour's values come from its FFPE-filtered analysis."],terms:[["Del. 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- {clonal|clonal}`:u.toFixed(2).replace(/0$/,""):u.toFixed(1),rich:{clonal:{color:i.faint,fontFamily:i.font,fontSize:10.5}}},splitLine:{show:!0,lineStyle:{color:i.grid}}},yAxis:{type:"value",show:!1,max:u=>Math.max(1,u.max)*1.25},tooltip:{trigger:"item",...No(i)},brush:{xAxisIndex:0,seriesIndex:[Ew],brushType:"lineX",brushMode:"single",transformable:!0,removeOnClick:!0,brushStyle:{color:$n(i.accent,.08),borderColor:$n(i.accent,.55),borderWidth:1},outOfBrush:{colorAlpha:.25},throttleType:"debounce",throttleDelay:120},series:[{id:"density",type:"line",name:o,data:s,smooth:.45,symbol:"none",silent:!0,lineStyle:{width:2.25,color:i.ccfLine},areaStyle:{color:{type:"linear",x:0,y:0,x2:0,y2:1,colorStops:[{offset:0,color:$n(i.ccfFill,.26)},{offset:1,color:$n(i.ccfFill,.02)}]}},markLine:n.measure==="ccf"?{silent:!0,symbol:"none",animation:!1,lineStyle:{color:i.axis,type:[4,4],width:1.25},label:{show:!1},data:[{xAxis:1}]}:void 0},{id:"drivers",type:"scatter",name:"Drivers",data:[...n.drivers].sort((u,f)=>u.value-f.value).map(u=>({value:[oh(n,u.value),h1(s,oh(n,u.value))],name:u.gene??"?",protein:u.protein_change,actual:u.value})),symbolSize:10,cursor:"pointer",itemStyle:{opacity:1,color:i.dot,borderColor:i.card,borderWidth:2.5,shadowBlur:6,shadowColor:$n(i.dot,.3)},emphasis:{scale:1.5},label:{show:!0,formatter:"{b}",position:"top",distance:10,color:i.ink,fontWeight:600,fontStyle:"italic",fontSize:11.5},labelLine:{show:!0,lineStyle:{color:i.axis,width:1}},labelLayout:o1({top:4}),tooltip:{formatter:u=>`<span style="font-weight:600"><i>${u.name}</i></span> ${u.data.protein??""}<div style="margin-top:3px">${o} <span style="font-weight:600">${u.data.actual.toFixed(2)}</span></div><div style="opacity:.7;font-size:11.5px;margin-top:5px">Driver. 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+ */const wC=Ue("Waves",[["path",{d:"M2 6c.6.5 1.2 1 2.5 1C7 7 7 5 9.5 5c2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"knzxuh"}],["path",{d:"M2 12c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"2jd2cc"}],["path",{d:"M2 18c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"rd2r6e"}]]);/**
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+ * @license lucide-react v0.468.0 - ISC
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+ *
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+ * This source code is licensed under the ISC license.
260
+ * See the LICENSE file in the root directory of this source tree.
261
+ */const Qu=Ue("X",[["path",{d:"M18 6 6 18",key:"1bl5f8"}],["path",{d:"m6 6 12 12",key:"d8bk6v"}]]);/**
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+ * @license lucide-react v0.468.0 - ISC
263
+ *
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+ * This source code is licensed under the ISC license.
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+ * See the LICENSE file in the root directory of this source tree.
266
+ */const CC=Ue("ZoomOut",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["line",{x1:"21",x2:"16.65",y1:"21",y2:"16.65",key:"13gj7c"}],["line",{x1:"8",x2:"14",y1:"11",y2:"11",key:"durymu"}]]);function jC(n){if(n.value===null)return n.text??"";switch(n.key){case"coverage":return`${Math.round(n.value)}×`;case"tmb":return n.value<.01?n.value.toPrecision(2):n.value.toFixed(2);default:return n.value.toFixed(2)}}function EC(n){return n.status==="failed"?"Failed":n.status==="skipped"?"Not in this mode":"Not run"}const NC=new Intl.DateTimeFormat("en-GB",{day:"numeric",month:"short",year:"numeric"});function O1(n){if(!n)return"";const s=new Date(n);return Number.isNaN(s.getTime())?"":NC.format(s)}function lm(n,s){return n.startsWith(`${s}_`)?n.slice(s.length+1):n}function Oh(n){return n==null?"–":n.toFixed(2)}const sy={missense_variant:"Missense",stop_gained:"Nonsense",stop_lost:"Stop lost",start_lost:"Start lost",frameshift_variant:"Frameshift",inframe_deletion:"In-frame 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f.jsxs("div",{className:"flex items-start gap-2.5 text-sm",style:{color:"var(--ink-2)"},children:[f.jsx(i,{size:18,"aria-hidden":!0,style:{color:s?"var(--warn-ink)":"var(--chev)",flex:"none"}}),f.jsxs("div",{className:"flex flex-col gap-1",children:[f.jsx("span",{className:"font-semibold",style:{color:"var(--ink)"},children:s?"This panel could not be read":"Nothing to show here"}),n.warnings.map(r=>f.jsx("span",{children:r},r))]})]})}const Lh={summary:{title:"Genome fingerprint and summary",intro:"A one-glance portrait of the selected tumour: its copy-number changes and driver mutations drawn as a ring, a sentence describing them, and the headline measurements of the sample.",sections:[{heading:"The fingerprint ring",paragraphs:["The ring is the whole genome. Chromosome 1 starts at the top and the ring runs clockwise through chromosome 22 to X, each chromosome's arc in proportion to its length (GRCh37).","Copy-number changes are called against the tumour's baseline, its ploidy rounded to whole copies. Very short changes are drawn at a minimum length so they stay visible."],terms:[["Gains (outer track, orange)","Regions with at least one copy more than the baseline."],["Amplifications (outer track, darker and thicker)","Regions with three or more copies above the baseline."],["Losses (inner track, blue)","Regions with at least one copy fewer than the baseline."],["Drivers (black ticks)","Where the tumour's likely driver mutations sit (see the Mutations card for how they are flagged)."]]},{heading:"The sentence",paragraphs:["Written from the same data as the ring: how many amplifications, gains and losses there are and on which chromosomes, and which genes carry driver mutations."]},{heading:"The measurements",paragraphs:["Each tile shows a value, a small picture of where it sits on its scale when it has a natural one, and the analysis it came from. A tile with no value says why: the analysis was not run, it failed, or it does not apply to this kind of report (tumour-only reports have no matched normal)."],terms:[["Purity","The estimated fraction of cells in the sample that are tumour cells, from 0 to 1. The ring fills to the value."],["Ploidy","The tumour's average number of copies across the genome. The scale runs from 1 to 6 copies; the tall tick marks 2, a diploid genome."],["Coverage","The median sequencing depth of the tumour across the genome, in reads (×)."],["TMB per Mb","Tumour mutational burden: somatic SNVs and indels per megabase of genome. The report computes it from the counts of the SNV and indel calls. The scale is logarithmic, 0.01 to 100."],["MSI score","The MSIsensor score: the percentage of microsatellite sites that look unstable in the tumour."],["FGA","Fraction of the genome altered: the share of the genome whose copy number differs from the baseline, from 0 to 1. It is read from the project-wide Battenberg tables."]]},{heading:"Linking back to the analyses",paragraphs:[`Every value names its analysis, with version and Isabl id. Picking an analysis in the side menu's "Analyses on this page" highlights the tiles and cards it feeds.`]}]},copyNumber:{title:"Copy number",intro:"How many copies of each part of the genome the tumour carries, segment by segment, from chromosome 1 to X.",sections:[{heading:"What is drawn",paragraphs:['Each horizontal stroke is one segment: a stretch of the genome with a constant copy number. Its height is the number of copies, from 0 up to 8; anything higher is drawn at the top and the axis reads "8+". A gain or amplification rises as a column from the baseline to its stroke, and a loss falls to it, so the changes read as a landscape. Alternating grey bands mark the chromosomes, named in a strip along the bottom.',`The line across the plot is the baseline: the tumour's ploidy rounded to whole copies (labelled, for example, "2 copies"). Segments are coloured by how they compare with it.`],terms:[["Grey","Neutral: the same number of copies as the baseline."],["Orange","Gain: at least one copy more than the baseline."],["Dark orange","Amplification: three or more copies above the baseline."],["Blue","Loss: at least one copy fewer than the baseline."]]},{heading:"Total or allele-specific",paragraphs:["Total shows all copies together. Allele-specific, when the analysis provides it, splits each segment into its major allele (the more common parental copy, dark) and minor allele (light). Where the two are equal they are drawn slightly apart so both stay visible. A minor allele of 0 means one parent's copy is lost there (loss of heterozygosity)."]},{heading:"Driver genes",paragraphs:["A label along the top names each gene with likely driver mutations, one per gene, joined by a line to a dot on the segment the gene sits on, so its copy number can be read off at once. Hover one for its protein changes and the copies there."]},{heading:"Reading and moving around",terms:[["Hover a segment","Its call, copies (major + minor), coordinates and, when available, log2 ratio. A readout at the foot of the plot gives the pointer's place on the genome."],["Click a segment","Lists the mutations inside it in the Mutations card."],["Click a driver","Finds that gene in the Mutations card."],["Pinch, or Ctrl and scroll","Zooms around the pointer. Plain scrolling always scrolls the page."],["Drag","Pans a zoomed view."],["Arrow keys, plus and minus, 0","With the plot focused: pan, zoom in and out, and show the whole genome."],["Double-click a chromosome, or click its name","Glides to fill the view with it; the strip then counts megabases."],["The overview","The whole genome in miniature under the strip. Its window shows where the plot is: drag the window to move, its ends to resize, or click elsewhere to centre it there. The button by the title returns to the whole genome."],["Hover a mutation in the table","Marks it here, with a ring on the segment it sits on and its copy number."]]},{heading:"Tumour-only reports",paragraphs:["Without a matched normal there is no ploidy estimate, so segments come from CNVkit and are called against two copies. Allele-specific copy numbers are not available."]}]},mutations:{title:"Mutations",intro:"The tumour's somatic SNVs and indels that passed the callers' filters: how they are distributed across cancer cells, and a searchable, filterable table of every call.",sections:[{heading:"Which mutations",terms:[["Drivers","Likely drivers flagged by the report: coding mutations that match OncoKB or COSMIC driver annotations (the exact protein change, or a damaging consequence in a known cancer gene), plus known hotspots the callers missed and the report recovered from the tumour's reads."],["Coding","Mutations whose effect changes a protein, by the report's list of coding effects."],["All","Every PASS SNV and indel."]],paragraphs:["The counts beside each choice follow the search and filters, so they always say what you would see."]},{heading:"FFPE samples",paragraphs:["Formalin-fixed (FFPE) tissue damages DNA in ways that look like mutations, mostly C>T changes at low allele fractions. For an FFPE sample, FFPERASE scores each SNV and indel for how likely it is to be such an artifact, and the report counts only the calls scored at or below its threshold (quoted beside the table). Its SNV, indel and coding totals and the TMB leave the rest out.",`The report marks each call it leaves out, and the dashboard follows that mark: the Coding and All counts, the table and the curve leave those calls out, and the card's subtitle says so. Drivers are all listed, as in the report, and any the filter would remove carry an "FFPE filtered" tag. "Show filtered calls", under FFPE filter beside the table, brings the removed calls back, tagged the same way.`]},{heading:"Cancer cell fraction and variant allele fraction",paragraphs:["The curve across the top is a smoothed histogram of every PASS mutation; driver mutations sit on it as labelled dots, and the diamond on the axis is the median. Switch between the two measures:"],terms:[["CCF",'Cancer cell fraction: the estimated share of cancer cells carrying the mutation, corrected for purity and copy number. Around 1 (the "clonal" mark) means nearly every cancer cell has it, which suggests it arose early; clearly below 1 means a subclone. Estimates can land somewhat above 1. Shown from 0 to 2.'],["VAF","Variant allele fraction: the share of sequencing reads at the position that carry the mutation, from 0 to 1. Raw, not corrected for purity or copy number. Tumour-only reports open on VAF, since CCF needs a matched normal."]]},{heading:"Filtering by the curve",paragraphs:["Drag across the curve to keep only mutations in that CCF or VAF range: the curve stays lit inside the range and fades outside it, and the range is read out at its foot. Drag the edges to resize it, or its body to move it. The range appears with the other filters and can be removed there, or by clicking the curve."]},{heading:"The table",terms:[["Gene and position","The gene, and the mutation's chromosome and position (GRCh37)."],["Change","The protein change, with the cDNA change beneath."],["Effect","What the mutation does to the gene, from the VEP consequence (or the report's effect). Truncating effects are in bold."],["VAF and CCF bars","The value with a bar for quick comparison; the CCF bar's tick marks 1, clonal."],["Driver","Flagged as a likely driver (shown when the table is not already limited to drivers)."],["Hotspot","The exact protein change is a known recurrent cancer hotspot."],["In DMP","The same mutation was also found by the patient's clinical MSK-IMPACT (DMP) sequencing."],["FFPE filtered","FFPE samples only: the report's FFPE artifact filter leaves this call out of its counts (see FFPE samples)."]]},{heading:"Opening a row",terms:[["Variant","SNV or indel, with the reference and alternate bases."],["Reads","Reads supporting the mutation out of all reads at the position. Only hotspots the report recovered from the tumour's reads have them; the callers' tables give no single count."],["Normal VAF","The mutation's allele fraction in the matched normal; near 0 for a somatic mutation."],["Mutant copies","How many copies of that part of the genome carry the mutation, out of all copies there."],["Consequence","The full VEP consequence."],["COSMIC","How many samples in COSMIC carry it, and how closely they match (exact change, same position, codon or gene)."],["Expression","The gene's expression in the tumour's RNA, in transcripts per million, when RNA was sequenced."],["Gene role","Whether the gene is a known oncogene or tumour suppressor gene (TSG)."],["Show on copy number","Zooms the Copy number card to the mutation's chromosome and marks it."]]},{heading:"Searching and filtering",paragraphs:["Search takes a gene, a protein or cDNA change, a COSMIC term, or a locus such as chr12:25,398,284 or a range such as chr8:1-50,000,000. Press / anywhere on the page to jump to it. Each filter's count is how many rows you would get by ticking it, given everything else."],terms:[["Missense","One amino acid replaced by another."],["Truncating","Stop gained or lost, start lost, or a frameshift."],["Splice","Changes a splice site or splice region."],["In-frame","Inserts or deletes amino acids without shifting the reading frame."],["Synonymous","Changes the DNA but not the amino acid."],["Other","Everything else, such as intronic, UTR or upstream changes."]]}]},structuralVariants:{title:"Structural variants",intro:"The tumour's rearrangements as the report shows them: those with a breakpoint in an oncogene or tumour suppressor, those that take in a whole gene, and how all of them group into rearrangement signatures.",sections:[{heading:"Which rearrangements",paragraphs:["The report works from the high-confidence structural variants of ANNOT_SVS, which keeps calls made by two or more callers (SvABA, BRASS and GRIDSS) and annotates the genes they touch with AnnotSV. The count beside the title is how many of these the report counts, its rearrangements total.",`The tables keep the rearrangements whose genes include an oncogene or tumour suppressor, by the report's gene lists. It also searches the callers' raw calls for known rearrangements the high-confidence set can miss, such as CIC fusions, and adds them; a rescued event that is not a two-caller PASS says so in its callers, as in "gridss (CIC rescued)".`]},{heading:"The two tables",terms:[["Rearranged oncogenes and tumour suppressors",'One row per rearrangement and gene it hits, with the gene and breakpoint on each side. A gene near a breakpoint rather than in it is named as the report names it, such as "TERT +/- 100Kb".'],["Whole-gene rearrangements","Rearrangements that take in a whole oncogene or tumour suppressor, from start to end: a deletion of the whole gene, for example."],["Role","Whether the row's genes include an oncogene, a tumour suppressor or both, as the report colours its rows. Click a role above the tables to show only its rows."],["Left and right","Each breakpoint's gene, position (GRCh37) and where it falls in the gene, as AnnotSV writes it (intron5, exon2-exon5). Breakpoints are ordered by chromosome, then position."],["Callers and support","The callers that made the call, and the most reads any of them gives in support."],["Pileups","Supporting reads over all reads at each breakpoint in the tumour's alignments, left then right."],["Expression","For tumours with RNA: whether each gene's expression is high or low against each expression cohort (p63 is cohort project 63): at or above its 90th percentile, at or below its 10th, or neither (None). N/A means the cohort has no value for the gene."]],paragraphs:["Open a row to see both breakpoints, show them on the copy-number card, or copy their IGV loci."]},{heading:"Rearrangement signatures",paragraphs:["WGSPOST groups the tumour's rearrangements the way rearrangement signatures are described: clustered (rearrangements that sit unusually close together, as in chromothripsis) or dispersed, then by class and, except for translocations, by size from under 1 kb to over 1 Mb. Each bar is how many rearrangements fall in a group, grouped under its class; lighter bars are the clustered ones, in the shaded zone. A group with none shows a short stub on the baseline. Hover a bar for its name and its share of all rearrangements, or a class in the key to light its bars.","WGSPOST counts from its own copy of the calls, so its total can differ slightly from the report's rearrangements count."],terms:[["Deletion","A stretch of the genome lost between two breakpoints."],["Tandem duplication","A stretch copied next to itself."],["Inversion","A stretch turned around in place."],["Translocation","A join between two chromosomes."]]}]},signaturesHrd:{title:"Signatures and HRD",intro:"Which mutational processes left their mark on the tumour, set against tumours of the same disease, and whether it shows homologous recombination deficiency (HRD), as the report shows them.",sections:[{heading:"Mutational signatures",paragraphs:["WGSPOST fits known COSMIC substitution signatures to the tumour's somatic SNVs and estimates how many mutations each one accounts for. 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  *
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  * Copyright (c) TanStack
@@ -264,10 +273,10 @@ Error generating stack: `+a.message+`
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  * LICENSE.md file in the root directory of this source tree.
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  *
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  * @license MIT
267
- */function Pl(n,i){return typeof n=="function"?n(i):n}function an(n,i){return s=>{i.setState(o=>({...o,[n]:Pl(s,o[n])}))}}function Du(n){return n instanceof Function}function Aw(n){return Array.isArray(n)&&n.every(i=>typeof i=="number")}function Ow(n,i){const s=[],o=u=>{u.forEach(f=>{s.push(f);const d=i(f);d!=null&&d.length&&o(d)})};return o(n),s}function de(n,i,s){let o=[],u;return f=>{let d;s.key&&s.debug&&(d=Date.now());const g=n(f);if(!(g.length!==o.length||g.some((y,v)=>o[v]!==y)))return u;o=g;let S;if(s.key&&s.debug&&(S=Date.now()),u=i(...g),s==null||s.onChange==null||s.onChange(u),s.key&&s.debug&&s!=null&&s.debug()){const y=Math.round((Date.now()-d)*100)/100,v=Math.round((Date.now()-S)*100)/100,b=v/16,C=(E,N)=>{for(E=String(E);E.length<N;)E=" "+E;return E};console.info(`%c⏱ ${C(v,5)} /${C(y,5)} ms`,`
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+ */function ba(n,s){return typeof n=="function"?n(s):n}function Sn(n,s){return i=>{s.setState(r=>({...r,[n]:ba(i,r[n])}))}}function Ju(n){return n instanceof Function}function hE(n){return Array.isArray(n)&&n.every(s=>typeof s=="number")}function mE(n,s){const i=[],r=u=>{u.forEach(d=>{i.push(d);const h=s(d);h!=null&&h.length&&r(h)})};return r(n),i}function xe(n,s,i){let r=[],u;return d=>{let h;i.key&&i.debug&&(h=Date.now());const m=n(d);if(!(m.length!==r.length||m.some((x,v)=>r[v]!==x)))return u;r=m;let y;if(i.key&&i.debug&&(y=Date.now()),u=s(...m),i==null||i.onChange==null||i.onChange(u),i.key&&i.debug&&i!=null&&i.debug()){const x=Math.round((Date.now()-h)*100)/100,v=Math.round((Date.now()-y)*100)/100,b=v/16,w=(C,N)=>{for(C=String(C);C.length<N;)C=" "+C;return C};console.info(`%c⏱ ${w(v,5)} /${w(x,5)} ms`,`
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  font-size: .6rem;
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270
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u;n.setPagination(o?Nd():(u=n.initialState.pagination)!=null?u:Nd())},n.setPageIndex=o=>{n.setPagination(u=>{let f=Pl(o,u.pageIndex);const d=typeof n.options.pageCount>"u"||n.options.pageCount===-1?Number.MAX_SAFE_INTEGER:n.options.pageCount-1;return f=Math.max(0,Math.min(f,d)),{...u,pageIndex:f}})},n.resetPageIndex=o=>{var u,f;n.setPageIndex(o?rh:(u=(f=n.initialState)==null||(f=f.pagination)==null?void 0:f.pageIndex)!=null?u:rh)},n.resetPageSize=o=>{var u,f;n.setPageSize(o?uh:(u=(f=n.initialState)==null||(f=f.pagination)==null?void 0:f.pageSize)!=null?u:uh)},n.setPageSize=o=>{n.setPagination(u=>{const f=Math.max(1,Pl(o,u.pageSize)),d=u.pageSize*u.pageIndex,g=Math.floor(d/f);return{...u,pageIndex:g,pageSize:f}})},n.setPageCount=o=>n.setPagination(u=>{var f;let d=Pl(o,(f=n.options.pageCount)!=null?f:-1);return typeof d=="number"&&(d=Math.max(-1,d)),{...u,pageCount:d}}),n.getPageOptions=de(()=>[n.getPageCount()],o=>{let u=[];return o&&o>0&&(u=[...new 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o;return(o=n.options.rowCount)!=null?o:n.getPrePaginationRowModel().rows.length}}},Md=()=>({top:[],bottom:[]}),s_={getInitialState:n=>({rowPinning:Md(),...n}),getDefaultOptions:n=>({onRowPinningChange:an("rowPinning",n)}),createRow:(n,i)=>{n.pin=(s,o,u)=>{const f=o?n.getLeafRows().map(p=>{let{id:S}=p;return S}):[],d=u?n.getParentRows().map(p=>{let{id:S}=p;return S}):[],g=new Set([...d,n.id,...f]);i.setRowPinning(p=>{var S,y;if(s==="bottom"){var v,b;return{top:((v=p==null?void 0:p.top)!=null?v:[]).filter(N=>!(g!=null&&g.has(N))),bottom:[...((b=p==null?void 0:p.bottom)!=null?b:[]).filter(N=>!(g!=null&&g.has(N))),...Array.from(g)]}}if(s==="top"){var C,E;return{top:[...((C=p==null?void 0:p.top)!=null?C:[]).filter(N=>!(g!=null&&g.has(N))),...Array.from(g)],bottom:((E=p==null?void 0:p.bottom)!=null?E:[]).filter(N=>!(g!=null&&g.has(N)))}}return{top:((S=p==null?void 0:p.top)!=null?S:[]).filter(N=>!(g!=null&&g.has(N))),bottom:((y=p==null?void 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u,f;return!!((u=o.top)!=null&&u.length||(f=o.bottom)!=null&&f.length)}return!!((s=o[i])!=null&&s.length)},n._getPinnedRows=(i,s,o)=>{var u;return((u=n.options.keepPinnedRows)==null||u?(s??[]).map(d=>{const g=n.getRow(d,!0);return g.getIsAllParentsExpanded()?g:null}):(s??[]).map(d=>i.find(g=>g.id===d))).filter(Boolean).map(d=>({...d,position:o}))},n.getTopRows=de(()=>[n.getRowModel().rows,n.getState().rowPinning.top],(i,s)=>n._getPinnedRows(i,s,"top"),he(n.options,"debugRows")),n.getBottomRows=de(()=>[n.getRowModel().rows,n.getState().rowPinning.bottom],(i,s)=>n._getPinnedRows(i,s,"bottom"),he(n.options,"debugRows")),n.getCenterRows=de(()=>[n.getRowModel().rows,n.getState().rowPinning.top,n.getState().rowPinning.bottom],(i,s,o)=>{const u=new Set([...s??[],...o??[]]);return 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o=!!i.length;return o&&i.some(u=>!s[u.id])&&(o=!1),o},n.getIsSomeRowsSelected=()=>{var i;const s=Object.keys((i=n.getState().rowSelection)!=null?i:{}).length;return s>0&&s<n.getFilteredRowModel().flatRows.length},n.getIsSomePageRowsSelected=()=>{const i=n.getPaginationRowModel().flatRows;return n.getIsAllPageRowsSelected()?!1:i.filter(s=>s.getCanSelect()).some(s=>s.getIsSelected()||s.getIsSomeSelected())},n.getToggleAllRowsSelectedHandler=()=>i=>{n.toggleAllRowsSelected(i.target.checked)},n.getToggleAllPageRowsSelectedHandler=()=>i=>{n.toggleAllPageRowsSelected(i.target.checked)}},createRow:(n,i)=>{n.toggleSelected=(s,o)=>{const u=n.getIsSelected();i.setRowSelection(f=>{var d;if(s=typeof s<"u"?s:!u,n.getCanSelect()&&u===s)return f;const g={...f};return ch(g,n.id,s,(d=o==null?void 0:o.selectChildren)!=null?d:!0,i),g})},n.getIsSelected=()=>{const{rowSelection:s}=i.getState();return Rh(n,s)},n.getIsSomeSelected=()=>{const{rowSelection:s}=i.getState();return fh(n,s)==="some"},n.getIsAllSubRowsSelected=()=>{const{rowSelection:s}=i.getState();return fh(n,s)==="all"},n.getCanSelect=()=>{var s;return typeof i.options.enableRowSelection=="function"?i.options.enableRowSelection(n):(s=i.options.enableRowSelection)!=null?s:!0},n.getCanSelectSubRows=()=>{var s;return typeof i.options.enableSubRowSelection=="function"?i.options.enableSubRowSelection(n):(s=i.options.enableSubRowSelection)!=null?s:!0},n.getCanMultiSelect=()=>{var s;return typeof i.options.enableMultiRowSelection=="function"?i.options.enableMultiRowSelection(n):(s=i.options.enableMultiRowSelection)!=null?s:!0},n.getToggleSelectedHandler=()=>{const s=n.getCanSelect();return o=>{var u;s&&n.toggleSelected((u=o.target)==null?void 0:u.checked)}}}},ch=(n,i,s,o,u)=>{var f;const d=u.getRow(i,!0);s?(d.getCanMultiSelect()||Object.keys(n).forEach(g=>delete n[g]),d.getCanSelect()&&(n[i]=!0)):delete n[i],o&&(f=d.subRows)!=null&&f.length&&d.getCanSelectSubRows()&&d.subRows.forEach(g=>ch(n,g.id,s,o,u))};function jd(n,i){const s=n.getState().rowSelection,o=[],u={},f=function(d,g){return d.map(p=>{var S;const y=Rh(p,s);if(y&&(o.push(p),u[p.id]=p),(S=p.subRows)!=null&&S.length&&(p={...p,subRows:f(p.subRows)}),y)return p}).filter(Boolean)};return{rows:f(i.rows),flatRows:o,rowsById:u}}function Rh(n,i){var s;return(s=i[n.id])!=null?s:!1}function fh(n,i,s){var o;if(!((o=n.subRows)!=null&&o.length))return!1;let u=!0,f=!1;return n.subRows.forEach(d=>{if(!(f&&!u)&&(d.getCanSelect()&&(Rh(d,i)?f=!0:u=!1),d.subRows&&d.subRows.length)){const g=fh(d,i);g==="all"?f=!0:(g==="some"&&(f=!0),u=!1)}}),u?"all":f?"some":!1}const dh=/([0-9]+)/gm,r_=(n,i,s)=>w1(ea(n.getValue(s)).toLowerCase(),ea(i.getValue(s)).toLowerCase()),u_=(n,i,s)=>w1(ea(n.getValue(s)),ea(i.getValue(s))),c_=(n,i,s)=>Th(ea(n.getValue(s)).toLowerCase(),ea(i.getValue(s)).toLowerCase()),f_=(n,i,s)=>Th(ea(n.getValue(s)),ea(i.getValue(s))),d_=(n,i,s)=>{const o=n.getValue(s),u=i.getValue(s);return o>u?1:o<u?-1:0},h_=(n,i,s)=>Th(n.getValue(s),i.getValue(s));function Th(n,i){return n===i?0:n>i?1:-1}function ea(n){return typeof n=="number"?isNaN(n)||n===1/0||n===-1/0?"":String(n):typeof n=="string"?n:""}function w1(n,i){const s=n.split(dh).filter(Boolean),o=i.split(dh).filter(Boolean);for(;s.length&&o.length;){const u=s.shift(),f=o.shift(),d=parseInt(u,10),g=parseInt(f,10),p=[d,g].sort();if(isNaN(p[0])){if(u>f)return 1;if(f>u)return-1;continue}if(isNaN(p[1]))return isNaN(d)?-1:1;if(d>g)return 1;if(g>d)return-1}return s.length-o.length}const io={alphanumeric:r_,alphanumericCaseSensitive:u_,text:c_,textCaseSensitive:f_,datetime:d_,basic:h_},m_={getInitialState:n=>({sorting:[],...n}),getDefaultColumnDef:()=>({sortingFn:"auto",sortUndefined:1}),getDefaultOptions:n=>({onSortingChange:an("sorting",n),isMultiSortEvent:i=>i.shiftKey}),createColumn:(n,i)=>{n.getAutoSortingFn=()=>{const s=i.getFilteredRowModel().flatRows.slice(10);let o=!1;for(const u of s){const f=u==null?void 0:u.getValue(n.id);if(Object.prototype.toString.call(f)==="[object Date]")return io.datetime;if(typeof f=="string"&&(o=!0,f.split(dh).length>1))return io.alphanumeric}return o?io.text:io.basic},n.getAutoSortDir=()=>{const s=i.getFilteredRowModel().flatRows[0];return typeof(s==null?void 0:s.getValue(n.id))=="string"?"asc":"desc"},n.getSortingFn=()=>{var s,o;if(!n)throw new Error;return Du(n.columnDef.sortingFn)?n.columnDef.sortingFn:n.columnDef.sortingFn==="auto"?n.getAutoSortingFn():(s=(o=i.options.sortingFns)==null?void 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279
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  * react-table
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  *
273
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  * Copyright (c) TanStack
@@ -276,4 +285,4 @@ Error generating stack: `+a.message+`
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  * LICENSE.md file in the root directory of this source tree.
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  *
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  * @license MIT
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s=this.getScrollOffset(),o=this.getMaxScrollOffset();if(s<0||s>o)return;if(this._iosDeferredAdjustment<0&&s>=o-1){this._iosDeferredAdjustment=0;return}const u=this._iosDeferredAdjustment;this._iosDeferredAdjustment=0,this._scrollToOffset(s,{adjustments:this.scrollAdjustments+=u,behavior:void 0})},this.rafId=null,this.getSize=()=>this.options.enabled?(this.scrollRect=this.scrollRect??this.options.initialRect,this.scrollRect[this.options.horizontal?"width":"height"]):(this.scrollRect=null,0),this.getScrollOffset=()=>this.options.enabled?(this.scrollOffset=this.scrollOffset??(typeof this.options.initialOffset=="function"?this.options.initialOffset():this.options.initialOffset),this.scrollOffset):(this.scrollOffset=null,0),this.getMeasurementOptions=Li(()=>[this.options.count,this.options.paddingStart,this.options.scrollMargin,this.options.getItemKey,this.options.enabled,this.options.lanes,this.options.laneAssignmentMode,this.options.gap],(s,o,u,f,d,g,p,S)=>(this.prevLanes!==void 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this.laneAssignments.keys())j>=s&&this.laneAssignments.delete(j);this.lanesChangedFlag&&(this.lanesChangedFlag=!1,this.lanesSettling=!0,this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.pendingMin=null),this.measurementsCache.length===0&&!this.lanesSettling&&(this.measurementsCache=this.options.initialMeasurementsCache,this.measurementsCache.forEach(j=>{this.itemSizeCache.set(j.key,j.size)}));const C=this.lanesSettling?0:this.pendingMin??0;if(this.pendingMin=null,this.lanesSettling&&this.measurementsCache.length===s&&(this.lanesSettling=!1),g===1){const j=s*2;let O=(v=this._singleLaneMeasurements)==null?void 0:v.flat;if(!O||O.length<j){const q=new Float64Array(j);O&&C>0&&q.set(O.subarray(0,C*2)),O=q}const G=C===0?new Array(s):this._singleLaneMeasurements.items.slice();let B;if(C===0)B=o+u;else{const q=C-1;B=O[q*2]+O[q*2+1]+S}for(let q=C;q<s;q++){const Z=f(q);G[q]=Z;const W=b.get(Z),oe=typeof W=="number"?W:this.options.estimateSize(q);O[q*2]=B,O[q*2+1]=oe,B+=oe+S}this._singleLaneMeasurements={flat:O,items:G};const K=E_(G,O);return this.measurementsCache=K,K}const E=this.measurementsCache.slice(0,C),N=new Array(g).fill(void 0),_=new Float64Array(g);let w=0;for(let j=0;j<C;j++){const O=E[j];O&&(N[O.lane]===void 0&&w++,N[O.lane]=j,_[O.lane]=O.end)}for(let j=C;j<s;j++){const O=f(j),G=this.laneAssignments.get(j);let B,K;const q=p==="estimate"||b.has(O);if(G!==void 0&&this.options.lanes>1){B=G;const Se=N[B],ae=Se!==void 0?E[Se]:void 0;K=ae?ae.end+S:o+u}else if(w===g){let Se=0,ae=_[0],Xe=N[0];for(let et=1;et<g;et++){const He=_[et];(He<ae||He===ae&&N[et]<Xe)&&(Se=et,ae=He,Xe=N[et])}B=Se,K=ae+S,q&&this.laneAssignments.set(j,B)}else B=j%this.options.lanes,K=o+u,q&&this.laneAssignments.set(j,B);const Z=b.get(O),W=typeof Z=="number"?Z:this.options.estimateSize(j),oe=K+W;E[j]={index:j,start:K,size:W,end:oe,key:O,lane:B},N[B]===void 0&&w++,N[B]=j,_[B]=oe}return this.measurementsCache=E,E},{key:!1,debug:()=>this.options.debug}),this.calculateRange=Li(()=>[this.getMeasurements(),this.getSize(),this.getScrollOffset(),this.options.lanes],(s,o,u,f)=>s.length===0||o===0?(this.range=null,null):(this.range=L_(s,o,u,f,f===1&&this._singleLaneMeasurements!==null?this._singleLaneMeasurements.flat:null),this.range),{key:!1,debug:()=>this.options.debug}),this.getVirtualIndexes=Li(()=>{let s=null,o=null;const u=this.calculateRange();return u&&(s=u.startIndex,o=u.endIndex),this.maybeNotify.updateDeps([this.isScrolling,s,o]),[this.options.rangeExtractor,this.options.overscan,this.options.count,s,o]},(s,o,u,f,d)=>f===null||d===null?[]:s({startIndex:f,endIndex:d,overscan:o,count:u}),{key:!1,debug:()=>this.options.debug}),this.indexFromElement=s=>{const o=this.options.indexAttribute,u=s.getAttribute(o);return u?parseInt(u,10):(console.warn(`Missing attribute name '${o}={index}' on measured element.`),-1)},this.shouldMeasureDuringScroll=s=>{var o;if(!this.scrollState||this.scrollState.behavior!=="smooth")return!0;const u=this.scrollState.index??((o=this.getVirtualItemForOffset(this.scrollState.lastTargetOffset))==null?void 0:o.index);if(u!==void 0&&this.range){const f=Math.max(this.options.overscan,Math.ceil((this.range.endIndex-this.range.startIndex)/2)),d=Math.max(0,u-f),g=Math.min(this.options.count-1,u+f);return s>=d&&s<=g}return!0},this.measureElement=s=>{if(!s){this.elementsCache.forEach((d,g)=>{d.isConnected||(this.observer.unobserve(d),this.elementsCache.delete(g))});return}const o=this.indexFromElement(s);if(!this.isIndexInRange(o))return;const u=this.options.getItemKey(o),f=this.elementsCache.get(u);f!==s&&(f&&this.observer.unobserve(f),this.observer.observe(s),this.elementsCache.set(u,s)),(!this.isScrolling||this.scrollState)&&this.shouldMeasureDuringScroll(o)&&this.resizeItem(o,this.options.measureElement(s,void 0,this))},this.resizeItem=(s,o)=>{var u,f,d;if(!this.isIndexInRange(s))return;let g,p,S;const y=(u=this._singleLaneMeasurements)==null?void 0:u.flat;if(this.options.lanes===1&&y!=null)S=this.options.getItemKey(s),p=y[s*2],g=y[s*2+1];else{const C=this.measurementsCache[s];if(!C)return;S=C.key,p=C.start,g=C.size}const v=this.itemSizeCache.get(S)??g,b=o-v;if(b!==0){const C=this.options.anchorTo==="end"&&((f=this.scrollState)==null?void 0:f.behavior)!=="smooth"&&this.getVirtualDistanceFromEnd()<=this.options.scrollEndThreshold,E=C?this.getTotalSize():0,N=this.getScrollOffset()+this.scrollAdjustments,w=!this.itemSizeCache.has(S)?p<N:p+v<=N&&this.scrollDirection!=="backward",j=((d=this.scrollState)==null?void 0:d.behavior)!=="smooth"&&(this.shouldAdjustScrollPositionOnItemSizeChange!==void 0?this.shouldAdjustScrollPositionOnItemSizeChange(this.measurementsCache[s]??{index:s,key:S,start:p,size:g,end:p+g,lane:0},b,this):w);(this.pendingMin===null||s<this.pendingMin)&&(this.pendingMin=s),this.itemSizeCache.set(S,o),this.itemSizeCacheVersion++;let O=!1;C?O=this.applyScrollAdjustment(this.getTotalSize()-E):j&&(O=this.applyScrollAdjustment(b)),this.notify(O),this._retryClampedAdjustment()}},this.getVirtualItems=Li(()=>[this.getVirtualIndexes(),this.getMeasurements()],(s,o)=>{const u=[];for(let f=0,d=s.length;f<d;f++){const g=s[f],p=o[g];u.push(p)}return u},{key:!1,debug:()=>this.options.debug}),this.getVirtualItemForOffset=s=>{var o;const u=this.getMeasurements();if(u.length===0)return;const f=(o=this._singleLaneMeasurements)==null?void 0:o.flat,d=this.options.lanes===1&&f!=null,g=N1(0,u.length-1,d?p=>f[p*2]:p=>B0(u[p]).start,s);return B0(u[g])},this.getMaxScrollOffset=()=>{if(!this.scrollElement)return 0;if("scrollHeight"in this.scrollElement)return this.options.horizontal?this.scrollElement.scrollWidth-this.scrollElement.clientWidth:this.scrollElement.scrollHeight-this.scrollElement.clientHeight;{const s=this.scrollElement.document.documentElement;return this.options.horizontal?s.scrollWidth-this.scrollElement.innerWidth:s.scrollHeight-this.scrollElement.innerHeight}},this.getVirtualDistanceFromEnd=()=>Math.max(this.getTotalSize()-this.getSize()-this.getScrollOffset(),0),this.getDistanceFromEnd=()=>Math.max(this.getMaxScrollOffset()-this.getScrollOffset(),0),this.isAtEnd=(s=this.options.scrollEndThreshold)=>this.getDistanceFromEnd()<=s,this.getOffsetForAlignment=(s,o,u=0)=>{if(!this.scrollElement)return 0;const f=this.getSize(),d=this.getScrollOffset();o==="auto"&&(o=s>=d+f?"end":"start"),o==="center"?s+=(u-f)/2:o==="end"&&(s-=f);const g=this.getMaxScrollOffset();return Math.max(Math.min(g,s),0)},this.getOffsetForIndex=(s,o="auto")=>{s=Math.max(0,Math.min(s,this.options.count-1));const u=this.getSize(),f=this.getScrollOffset(),d=this.measurementsCache[s];if(!d)return;if(o==="auto")if(d.end>=f+u-this.options.scrollPaddingEnd)o="end";else if(d.start<=f+this.options.scrollPaddingStart)o="start";else return[f,o];if(o==="end"&&s===this.options.count-1)return[this.getMaxScrollOffset(),o];const g=o==="end"?d.end+this.options.scrollPaddingEnd:d.start-this.options.scrollPaddingStart;return[this.getOffsetForAlignment(g,o,d.size),o]},this.scrollToOffset=(s,{align:o="start",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0;const f=this.getOffsetForAlignment(s,o),d=this.now();this.scrollState={index:null,align:o,behavior:u,startedAt:d,lastTargetOffset:f,stableFrames:0},this._scrollToOffset(f,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollToIndex=(s,{align:o="auto",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0,s=Math.max(0,Math.min(s,this.options.count-1));const f=this.getOffsetForIndex(s,o);if(!f)return;const[d,g]=f,p=this.now();this.scrollState={index:s,align:g,behavior:u,startedAt:p,lastTargetOffset:d,stableFrames:0},this._scrollToOffset(d,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollBy=(s,{behavior:o="auto"}={})=>{const u=this.getScrollOffset()+s,f=this.now();this.scrollState={index:null,align:"start",behavior:o,startedAt:f,lastTargetOffset:u,stableFrames:0},this._scrollToOffset(u,{adjustments:void 0,behavior:o}),this.scheduleScrollReconcile()},this.scrollToEnd=({behavior:s="auto"}={})=>{if(this.options.count>0){this.scrollToIndex(this.options.count-1,{align:"end",behavior:s});return}this.scrollToOffset(Math.max(this.getTotalSize()-this.getSize(),0),{behavior:s})},this.getTotalSize=()=>{var s,o;const u=this.getMeasurements();let f;if(u.length===0)f=this.options.paddingStart;else if(this.options.lanes===1){const d=u.length-1,g=(s=this._singleLaneMeasurements)==null?void 0:s.flat;g!=null?f=g[d*2]+g[d*2+1]:f=((o=u[d])==null?void 0:o.end)??0}else{const d=Array(this.options.lanes).fill(null);let g=u.length-1;for(;g>=0&&d.some(p=>p===null);){const p=u[g];d[p.lane]===null&&(d[p.lane]=p.end),g--}f=Math.max(...d.filter(p=>p!==null))}return Math.max(f-this.options.scrollMargin+this.options.paddingEnd,0)},this.takeSnapshot=()=>{const s=[];if(this.itemSizeCache.size===0)return s;const o=this.getMeasurements();for(const u of o)u&&this.itemSizeCache.has(u.key)&&s.push({index:u.index,key:u.key,start:u.start,size:u.size,end:u.end,lane:u.lane});return s},this._scrollToOffset=(s,{adjustments:o,behavior:u})=>{this._intendedScrollOffset=s+(o??0),this.options.scrollToFn(s,{behavior:u,adjustments:o},this)},this.measure=()=>{this.pendingMin=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.itemSizeCacheVersion++,this.notify(!1)},this.setOptions(i)}applyScrollAdjustment(i,s){if(i===0)return!1;if(Ad()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded))return this._iosDeferredAdjustment+=i,!1;{const o=this.getScrollOffset()+this.scrollAdjustments+i,u=this.scrollElement,f=u!==null&&("scrollHeight"in u||"document"in u)?this.getMaxScrollOffset():null;return this._clampedAdjustment=f!==null&&o>f+.5?{target:o,maxAtWrite:f}:null,this._scrollToOffset(this.getScrollOffset(),{adjustments:this.scrollAdjustments+=i,behavior:s}),this.scrollOffset!==null&&(this.scrollOffset+=this.scrollAdjustments,this.scrollOffset<0&&(this.scrollOffset=0),this.scrollAdjustments=0),!0}}scheduleScrollReconcile(){if(!this.targetWindow){this.scrollState=null;return}this.rafId==null&&(this.rafId=this.targetWindow.requestAnimationFrame(()=>{this.rafId=null,this.reconcileScroll()}))}reconcileScroll(){if(!this.scrollState||!this.scrollElement)return;if(this.now()-this.scrollState.startedAt>5e3){this.scrollState=null;return}const o=this.scrollState.index!=null?this.getOffsetForIndex(this.scrollState.index,this.scrollState.align):void 0,u=o?o[0]:this.scrollState.lastTargetOffset,f=1,d=u!==this.scrollState.lastTargetOffset;if(!d&&G0(u,this.getScrollOffset())){if(this.scrollState.stableFrames++,this.scrollState.stableFrames>=f){this.getScrollOffset()!==u&&this._scrollToOffset(u,{adjustments:void 0,behavior:"auto"}),this.scrollState=null;return}}else if(this.scrollState.stableFrames=0,d){const g=this.getSize()||600,p=Math.abs(u-this.getScrollOffset()),S=this.scrollState.behavior==="smooth"&&p>g;this.scrollState.lastTargetOffset=u,S||(this.scrollState.behavior="auto"),this._scrollToOffset(u,{adjustments:void 0,behavior:S?"smooth":"auto"})}this.scheduleScrollReconcile()}}const N1=(n,i,s,o)=>{for(;n<=i;){const u=(n+i)/2|0,f=s(u);if(f<o)n=u+1;else if(f>o)i=u-1;else return u}return n>0?n-1:0};function H_(n,i,s){let o=0;for(;o<=i;){const u=(o+i)/2|0,f=n[u*2];if(f<s)o=u+1;else if(f>s)i=u-1;else return u}return o>0?o-1:0}function L_(n,i,s,o,u){const f=n.length-1;if(n.length<=o)return{startIndex:0,endIndex:f};if(o===1&&u!==null){const S=H_(u,f,s);let y=S;const v=s+i;for(;y<f&&u[y*2]+u[y*2+1]<v;)y++;return{startIndex:S,endIndex:y}}let g=N1(0,f,S=>n[S].start,s),p=g;if(o===1)for(;p<f&&n[p].end<s+i;)p++;else if(o>1){const S=Array(o).fill(0);for(;p<f&&S.some(v=>v<s+i);){const v=n[p];S[v.lane]=v.end,p++}const y=Array(o).fill(s+i);for(;g>=0&&y.some(v=>v>=s);){const v=n[g];y[v.lane]=v.start,g--}g=Math.max(0,g-g%o),p=Math.min(f,p+(o-1-p%o))}return{startIndex:g,endIndex:p}}const Od=typeof document<"u"?T.useLayoutEffect:T.useEffect;function V_({useFlushSync:n=!0,directDomUpdates:i=!1,directDomUpdatesMode:s="transform",...o}){const u=T.useReducer(v=>v+1,0)[1],f=T.useRef({enabled:i,mode:s,container:null,lastSize:null,lastPositions:new WeakMap,prevRange:null});f.current.enabled=i,f.current.mode=s;const d=T.useRef(!1),g=v=>{const b=f.current;if(!b.enabled||!b.container)return;const C=v.getTotalSize();if(C!==b.lastSize){b.lastSize=C;const E=v.options.horizontal?"width":"height";b.container.style[E]=`${C}px`}},p=v=>{const b=f.current;if(!b.enabled||!b.container)return;g(v);const C=!!v.options.horizontal,E=b.mode==="transform",N=C?"left":"top",_=v.options.scrollMargin,w=v.getVirtualItems();for(const j of w){const O=j.start-_,G=v.elementsCache.get(j.key);G&&b.lastPositions.get(G)!==O&&(b.lastPositions.set(G,O),E?G.style.transform=C?`translate3d(${O}px, 0, 0)`:`translate3d(0, ${O}px, 0)`:G.style[N]=`${O}px`)}},S={...o,onChange:(v,b)=>{var C;const E=f.current;let N=!0;if(E.enabled){p(v);const _=v.range,w=E.prevRange;N=!w||w.isScrolling!==v.isScrolling||w.startIndex!==(_==null?void 0:_.startIndex)||w.endIndex!==(_==null?void 0:_.endIndex),N&&(E.prevRange=_?{startIndex:_.startIndex,endIndex:_.endIndex,isScrolling:v.isScrolling}:null)}N&&(n&&b&&!d.current?by.flushSync(u):u()),(C=o.onChange)==null||C.call(o,v,b)}},[y]=T.useState(()=>{const v=new U_(S),b=v.measureElement;return v.measureElement=C=>{d.current=!0;try{b(C)}finally{d.current=!1}},Object.assign(v,{containerRef:C=>{const E=f.current;if(E.container=C,E.lastSize=null,C&&E.enabled){const N=v.getTotalSize();E.lastSize=N;const _=v.options.horizontal?"width":"height";C.style[_]=`${N}px`}}})});return y.setOptions(S),Od(()=>y._didMount(),[]),Od(()=>(g(y),y._willUpdate())),Od(()=>{p(y)}),y}function F_(n){return V_({observeElementRect:T_,observeElementOffset:j_,scrollToFn:z_,...n})}const mu=58,Vi=38,B_=25;function M1({items:n,scrollRef:i,columnCount:s,getKey:o,render:u,onEndReached:f,endThreshold:d=15}){var N;const g=F_({count:n.length,getScrollElement:()=>i.current,estimateSize:()=>mu,overscan:8,scrollMargin:Vi,getItemKey:_=>o(n[_],_),initialRect:{width:1e3,height:Vi+mu*10}}),p=!((N=g.scrollRect)!=null&&N.height),S=p?n.slice(0,B_).map((_,w)=>({key:o(_,w),index:w,start:Vi+w*mu,end:Vi+(w+1)*mu})):g.getVirtualItems(),y=S[0],v=S[S.length-1],b=(v==null?void 0:v.index)??-1;T.useEffect(()=>{f&&b>=0&&b>=n.length-d&&f()},[b,n.length,d,f]);const C=!p&&y?y.start-Vi:0,E=!p&&v?g.getTotalSize()-(v.end-Vi):0;return h.jsxs(h.Fragment,{children:[C>0&&h.jsx("tbody",{"aria-hidden":!0,children:h.jsx("tr",{className:"vt-spacer",style:{height:C},children:h.jsx("td",{colSpan:s})})}),S.map(_=>h.jsx("tbody",{"data-index":_.index,ref:p?void 0:g.measureElement,children:u(n[_.index],_.index)},_.key)),E>0&&h.jsx("tbody",{"aria-hidden":!0,children:h.jsx("tr",{className:"vt-spacer",style:{height:E},children:h.jsx("td",{colSpan:s})})})]})}function fo({text:n,query:i}){const s=i.trim();if(!s||SE(s))return h.jsx(h.Fragment,{children:n});const o=[],u=n.toLowerCase(),f=s.toLowerCase();let d=0;for(let g=u.indexOf(f);g!==-1;g=u.indexOf(f,d))g>d&&o.push(n.slice(d,g)),o.push(h.jsx("mark",{children:n.slice(g,g+s.length)},g)),d=g+s.length;return o.push(n.slice(d)),h.jsx(h.Fragment,{children:o})}function k0({value:n,max:i,clonal:s}){return n===null?h.jsx("span",{style:{color:"var(--chev)"},children:"–"}):h.jsxs("span",{className:"vbar",children:[h.jsx("span",{className:"vbar-n",children:th(n)}),h.jsxs("span",{className:"vbar-track","aria-hidden":!0,children:[h.jsx("span",{className:"vbar-fill",style:{width:`${Math.min(n/i,1)*100}%`}}),s&&h.jsx("span",{className:"vbar-tick",style:{left:`${1/i*100}%`}})]})]})}function G_({variant:n,showDriver:i}){return h.jsxs("span",{className:"flex flex-wrap gap-1.5",children:[i&&n.is_driver&&h.jsx("span",{className:"sc-pill p-neu",children:"Driver"}),n.hotspot&&h.jsx("span",{className:"sc-pill p-hot",children:"Hotspot"}),n.in_dmp&&h.jsx("span",{className:"sc-pill p-dmp",children:"In DMP"}),n.ffpe_removed&&h.jsx("span",{className:"sc-pill p-ffpe",title:"Left out of the report's counts by its FFPE artifact filter",children:"FFPE filtered"})]})}function q_(n){return`${n.ref}>${n.alt}`}function k_({variant:n,onLocate:i}){const[s,o]=T.useState(!1),u=`chr${n.chrom}:${n.pos}`,f=[["Variant",`${n.kind==="snv"?"SNV":n.kind==="indel"?"Indel":n.kind}, ${q_(n)}`],...n.depth!==null?[["Reads",`${n.alt_reads??"?"} of ${n.depth}`]]:[],["Normal VAF",th(n.normal_vaf)],["Mutant copies",EE(n.mut_alleles)??"–"],["Consequence",(n.consequence??n.effect??"–").replace(/&/g,", ")],["COSMIC",CE(n.cosmic)??"–"],...n.ffpe_score!==null||n.ffpe_removed?[["FFPE artifact score",n.ffpe_score!==null?th(n.ffpe_score):"Not scored"]]:[],["Expression",n.gene_tpm!==null?`${n.gene_tpm.toFixed(1)} TPM`:"–"],["Gene role",wE(n)??"–"]];return h.jsxs("div",{className:"vt-detail-body",children:[h.jsx("dl",{className:"vt-facts",children:f.map(([d,g])=>h.jsxs("div",{children:[h.jsx("dt",{children:d}),h.jsx("dd",{children:g})]},d))}),h.jsxs("div",{className:"flex flex-wrap items-center gap-2",children:[h.jsxs("button",{type:"button",className:"sc-btn sc-b2 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Q_({data:n,rows:i,hasMore:s,loadingMore:o,onMore:u,table:f,fetching:d,showCcf:g,onTable:p,onHover:S,onLocate:y}){const[v,b]=T.useState({}),C=f.q,E=f.scope!=="drivers",N=T.useMemo(()=>[{id:"expand",header:()=>h.jsx("span",{className:"sr-only",children:"Details"}),meta:{className:"pin vt-x"},cell:({row:q})=>h.jsx("button",{type:"button",className:"vt-expand","aria-expanded":q.getIsExpanded(),"aria-label":`Details of ${q.original.gene??"this mutation"} ${q.original.protein_change??""}`.trim(),onClick:Z=>{Z.stopPropagation(),q.toggleExpanded()},onFocus:()=>S(q.original),children:h.jsx(Ch,{size:14,"aria-hidden":!0})})},{id:"gene",header:"Gene",meta:{className:"pin vt-g",sorts:[{key:"gene",label:"Gene"},{key:"position",label:"Position"}]},cell:({row:{original:q}})=>h.jsxs(h.Fragment,{children:[h.jsx("span",{className:"vt-gene",children:h.jsx(fo,{text:q.gene??"–",query:C})}),h.jsx("span",{className:"vt-sub 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0,children:JC(q.consequence,q.effect)})},{id:"vaf",header:"VAF",meta:{className:"n",sorts:[{key:"vaf",label:"VAF",descFirst:!0}]},cell:({row:{original:q}})=>h.jsx(k0,{value:q.vaf,max:1})},...g?[{id:"ccf",header:"CCF",meta:{className:"n",sorts:[{key:"ccf",label:"CCF",descFirst:!0}]},cell:({row:{original:q}})=>h.jsx(k0,{value:q.ccf,max:1.25,clonal:!0})}]:[],{id:"flags",header:"Flags",cell:({row:{original:q}})=>h.jsx(G_,{variant:q,showDriver:E})}],[C,E,g,S]),_=T1({data:i,columns:N,getRowId:yE,getCoreRowModel:_1(),getExpandedRowModel:R1(),getRowCanExpand:()=>!0,manualPagination:!0,state:{expanded:v},onExpandedChange:b}),w=f.sort.replace(/^-/,""),j=_.getVisibleLeafColumns().length,O=Zy(f)>0,G=T.useRef(null),B=JSON.stringify([f.scope,f.sort,f.q,f.effects,f.flags,f.range,f.ffpe]);T.useEffect(()=>{G.current&&(G.current.scrollTop=0)},[B]);const K=q=>q.toLocaleString("en-US");return h.jsxs("div",{className:"flex min-w-0 flex-col",children:[h.jsxs("div",{ref:G,className:"vt-scroll 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h.jsxs(Ou,{ref:O,title:"Mutations",subtitle:K!==void 0?`${Z(K)} PASS SNVs and indels${q&&!q.shown?", after the FFPE filter":""}`:void 0,lineage:i1(p==null?void 0:p.lineage,i==null?void 0:i.lineage),picked:y,className:"mut",info:"mutations",expandable:!0,controls:h.jsxs(h.Fragment,{children:[h.jsx(g1,{value:C.q,onChange:ae=>E({q:ae})}),h.jsx(zu,{label:"Which mutations",value:C.scope,onChange:ae=>E({scope:ae,sort:Ky[ae]}),options:[{value:"drivers",label:h.jsxs(h.Fragment,{children:["Drivers",h.jsx("span",{className:"seg-n",children:Z(B==null?void 0:B.drivers)})]})},{value:"coding",label:h.jsxs(h.Fragment,{children:["Coding",h.jsx("span",{className:"seg-n",children:Z(B==null?void 0:B.coding)})]})},{value:"all",label:h.jsxs(h.Fragment,{children:["All",h.jsx("span",{className:"seg-n",children:Z(B==null?void 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uR({rows:n,shown:i,onToggle:s}){const o=J_(n);return h.jsx("div",{className:"sv-legend",role:"group","aria-label":"Show rows by gene role",children:j1.filter(u=>o[u]>0).map(u=>h.jsxs("button",{type:"button",className:`sv-legend-item p-${u==="oncogene"?"onco":u}`,"aria-pressed":i.includes(u),onClick:()=>s(u),children:[Nh[u],h.jsx("span",{className:"sv-legend-n",children:o[u]})]},u))})}function $0({gene:n,chrom:i,pos:s,loc:o,query:u}){return h.jsxs(h.Fragment,{children:[h.jsxs("span",{className:"sv-end",children:[h.jsx("span",{className:"vt-gene",children:h.jsx(fo,{text:n||"–",query:u})}),o&&h.jsx("span",{className:"sv-loc",children:o})]}),h.jsx("span",{className:"vt-sub mono",children:i&&s!==null?vo(i,s):"–"})]})}function z1(n){return n?n.replace(/,\s*/g,", "):"–"}function cR({label:n,sorted:i,onClick:s}){return h.jsxs("button",{type:"button",className:"vt-sort","data-active":!!i,onClick:s,title:`Sort by 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h.jsxs("div",{className:"vt-detail-body",children:[h.jsx("dl",{className:"vt-facts",children:d.map(([S,y])=>h.jsxs("div",{children:[h.jsx("dt",{children:S}),h.jsx("dd",{children:y})]},S))}),h.jsxs("div",{className:"flex flex-wrap items-center gap-2",children:[u&&h.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:()=>i({...u,gene:g}),children:[h.jsx(eh,{size:14,"aria-hidden":!0}),"Show ",f&&f.chrom===u.chrom?"it":"left breakpoint"," on copy number"]}),f&&f.chrom!==(u==null?void 0:u.chrom)&&h.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:()=>i({...f,gene:p}),children:[h.jsx(eh,{size:14,"aria-hidden":!0}),"Show right breakpoint on copy number"]}),n.igv_locus&&h.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:async()=>{try{await navigator.clipboard.writeText(n.igv_locus??""),o(!0),window.setTimeout(()=>o(!1),1500)}catch{window.prompt("Copy these IGV loci",n.igv_locus??"")}},children:[h.jsx(Vy,{size:14,"aria-hidden":!0}),s?"Copied":"Copy IGV loci"]})]})]})}function Q0({kind:n,rows:i,query:s="",onLocate:o}){const[u,f]=T.useState({}),[d,g]=T.useState([]),p=T.useRef(null),S=P_(i);T.useEffect(()=>{p.current&&(p.current.scrollTop=0)},[s,i.length]);const y=T.useMemo(()=>{const C={id:"expand",header:()=>h.jsx("span",{className:"sr-only",children:"Details"}),enableSorting:!1,meta:{className:"pin vt-x"},cell:({row:_})=>h.jsx("button",{type:"button",className:"vt-expand","aria-expanded":_.getIsExpanded(),"aria-label":`Details of ${_.original.gene??[_.original.left_gene,_.original.right_gene].filter(Boolean).join(" and 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288
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d=this.pendingScrollAnchor;if(this.pendingScrollAnchor=null,d&&this.scrollElement&&this.options.enabled){const[h,m,p,y]=d;h!==null&&!p&&(lh()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded)?y!==0&&(this._iosDeferredAdjustment+=y):((r=this.scrollState)==null?void 0:r.behavior)==="smooth"&&!jy(this.getScrollOffset()-y,this.scrollState.lastTargetOffset)||this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})),p&&this.scrollToEnd({behavior:p})}this._retryClampedAdjustment()},this._retryClampedAdjustment=()=>{if(this._clampedAdjustment===null||!this.scrollElement||!this.options.enabled)return;const{target:i,maxAtWrite:r}=this._clampedAdjustment,u=this.getMaxScrollOffset();u>r+.5&&(this._clampedAdjustment=i>u+.5?{target:i,maxAtWrite:u}:null,this._scrollToOffset(i,{adjustments:void 0,behavior:void 0}))},this._flushIosDeferredIfReady=()=>{if(this._iosDeferredAdjustment===0||this.isScrolling||this._iosTouching||this._iosJustTouchEnded)return;const i=this.getScrollOffset(),r=this.getMaxScrollOffset();if(i<0||i>r)return;if(this._iosDeferredAdjustment<0&&i>=r-1){this._iosDeferredAdjustment=0;return}const u=this._iosDeferredAdjustment;this._iosDeferredAdjustment=0,this._scrollToOffset(i,{adjustments:this.scrollAdjustments+=u,behavior:void 0})},this.rafId=null,this.getSize=()=>this.options.enabled?(this.scrollRect=this.scrollRect??this.options.initialRect,this.scrollRect[this.options.horizontal?"width":"height"]):(this.scrollRect=null,0),this.getScrollOffset=()=>this.options.enabled?(this.scrollOffset=this.scrollOffset??(typeof this.options.initialOffset=="function"?this.options.initialOffset():this.options.initialOffset),this.scrollOffset):(this.scrollOffset=null,0),this.getMeasurementOptions=ai(()=>[this.options.count,this.options.paddingStart,this.options.scrollMargin,this.options.getItemKey,this.options.enabled,this.options.lanes,this.options.laneAssignmentMode,this.options.gap],(i,r,u,d,h,m,p,y)=>(this.prevLanes!==void 0&&this.prevLanes!==m&&(this.lanesChangedFlag=!0),this.prevLanes=m,this.pendingMin=null,{count:i,paddingStart:r,scrollMargin:u,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:p,gap:y}),{key:!1}),this.isIndexInRange=i=>i>=0&&i<this.options.count,this.getMeasurements=ai(()=>[this.getMeasurementOptions(),this.itemSizeCacheVersion],({count:i,paddingStart:r,scrollMargin:u,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:p,gap:y},x)=>{var v;const b=this.itemSizeCache;if(!h)return this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),[];if(this.laneAssignments.size>i)for(const j of this.laneAssignments.keys())j>=i&&this.laneAssignments.delete(j);this.lanesChangedFlag&&(this.lanesChangedFlag=!1,this.lanesSettling=!0,this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.pendingMin=null),this.measurementsCache.length===0&&!this.lanesSettling&&(this.measurementsCache=this.options.initialMeasurementsCache,this.measurementsCache.forEach(j=>{this.itemSizeCache.set(j.key,j.size)}));const w=this.lanesSettling?0:this.pendingMin??0;if(this.pendingMin=null,this.lanesSettling&&this.measurementsCache.length===i&&(this.lanesSettling=!1),m===1){const j=i*2;let F=(v=this._singleLaneMeasurements)==null?void 0:v.flat;if(!F||F.length<j){const z=new Float64Array(j);F&&w>0&&z.set(F.subarray(0,w*2)),F=z}const T=w===0?new Array(i):this._singleLaneMeasurements.items.slice();let H;if(w===0)H=r+u;else{const z=w-1;H=F[z*2]+F[z*2+1]+y}for(let z=w;z<i;z++){const Y=d(z);T[z]=Y;const te=b.get(Y),k=typeof te=="number"?te:this.options.estimateSize(z);F[z*2]=H,F[z*2+1]=k,H+=k+y}this._singleLaneMeasurements={flat:F,items:T};const D=sN(T,F);return this.measurementsCache=D,D}const C=this.measurementsCache.slice(0,w),N=new Array(m).fill(void 0),M=new Float64Array(m);let R=0;for(let j=0;j<w;j++){const F=C[j];F&&(N[F.lane]===void 0&&R++,N[F.lane]=j,M[F.lane]=F.end)}for(let j=w;j<i;j++){const F=d(j),T=this.laneAssignments.get(j);let H,D;const z=p==="estimate"||b.has(F);if(T!==void 0&&this.options.lanes>1){H=T;const ne=N[H],ie=ne!==void 0?C[ne]:void 0;D=ie?ie.end+y:r+u}else if(R===m){let ne=0,ie=M[0],Ce=N[0];for(let X=1;X<m;X++){const ee=M[X];(ee<ie||ee===ie&&N[X]<Ce)&&(ne=X,ie=ee,Ce=N[X])}H=ne,D=ie+y,z&&this.laneAssignments.set(j,H)}else H=j%this.options.lanes,D=r+u,z&&this.laneAssignments.set(j,H);const Y=b.get(F),te=typeof Y=="number"?Y:this.options.estimateSize(j),k=D+te;C[j]={index:j,start:D,size:te,end:k,key:F,lane:H},N[H]===void 0&&R++,N[H]=j,M[H]=k}return this.measurementsCache=C,C},{key:!1,debug:()=>this.options.debug}),this.calculateRange=ai(()=>[this.getMeasurements(),this.getSize(),this.getScrollOffset(),this.options.lanes],(i,r,u,d)=>i.length===0||r===0?(this.range=null,null):(this.range=xN(i,r,u,d,d===1&&this._singleLaneMeasurements!==null?this._singleLaneMeasurements.flat:null),this.range),{key:!1,debug:()=>this.options.debug}),this.getVirtualIndexes=ai(()=>{let i=null,r=null;const u=this.calculateRange();return u&&(i=u.startIndex,r=u.endIndex),this.maybeNotify.updateDeps([this.isScrolling,i,r]),[this.options.rangeExtractor,this.options.overscan,this.options.count,i,r]},(i,r,u,d,h)=>d===null||h===null?[]:i({startIndex:d,endIndex:h,overscan:r,count:u}),{key:!1,debug:()=>this.options.debug}),this.indexFromElement=i=>{const r=this.options.indexAttribute,u=i.getAttribute(r);return u?parseInt(u,10):(console.warn(`Missing attribute name '${r}={index}' on measured element.`),-1)},this.shouldMeasureDuringScroll=i=>{var r;if(!this.scrollState||this.scrollState.behavior!=="smooth")return!0;const u=this.scrollState.index??((r=this.getVirtualItemForOffset(this.scrollState.lastTargetOffset))==null?void 0:r.index);if(u!==void 0&&this.range){const d=Math.max(this.options.overscan,Math.ceil((this.range.endIndex-this.range.startIndex)/2)),h=Math.max(0,u-d),m=Math.min(this.options.count-1,u+d);return i>=h&&i<=m}return!0},this.measureElement=i=>{if(!i){this.elementsCache.forEach((h,m)=>{h.isConnected||(this.observer.unobserve(h),this.elementsCache.delete(m))});return}const r=this.indexFromElement(i);if(!this.isIndexInRange(r))return;const u=this.options.getItemKey(r),d=this.elementsCache.get(u);d!==i&&(d&&this.observer.unobserve(d),this.observer.observe(i),this.elementsCache.set(u,i)),(!this.isScrolling||this.scrollState)&&this.shouldMeasureDuringScroll(r)&&this.resizeItem(r,this.options.measureElement(i,void 0,this))},this.resizeItem=(i,r)=>{var u,d,h;if(!this.isIndexInRange(i))return;let m,p,y;const x=(u=this._singleLaneMeasurements)==null?void 0:u.flat;if(this.options.lanes===1&&x!=null)y=this.options.getItemKey(i),p=x[i*2],m=x[i*2+1];else{const w=this.measurementsCache[i];if(!w)return;y=w.key,p=w.start,m=w.size}const v=this.itemSizeCache.get(y)??m,b=r-v;if(b!==0){const w=this.options.anchorTo==="end"&&((d=this.scrollState)==null?void 0:d.behavior)!=="smooth"&&this.getVirtualDistanceFromEnd()<=this.options.scrollEndThreshold,C=w?this.getTotalSize():0,N=this.getScrollOffset()+this.scrollAdjustments,R=!this.itemSizeCache.has(y)?p<N:p+v<=N&&this.scrollDirection!=="backward",j=((h=this.scrollState)==null?void 0:h.behavior)!=="smooth"&&(this.shouldAdjustScrollPositionOnItemSizeChange!==void 0?this.shouldAdjustScrollPositionOnItemSizeChange(this.measurementsCache[i]??{index:i,key:y,start:p,size:m,end:p+m,lane:0},b,this):R);(this.pendingMin===null||i<this.pendingMin)&&(this.pendingMin=i),this.itemSizeCache.set(y,r),this.itemSizeCacheVersion++;let F=!1;w?F=this.applyScrollAdjustment(this.getTotalSize()-C):j&&(F=this.applyScrollAdjustment(b)),this.notify(F),this._retryClampedAdjustment()}},this.getVirtualItems=ai(()=>[this.getVirtualIndexes(),this.getMeasurements()],(i,r)=>{const u=[];for(let d=0,h=i.length;d<h;d++){const m=i[d],p=r[m];u.push(p)}return u},{key:!1,debug:()=>this.options.debug}),this.getVirtualItemForOffset=i=>{var r;const u=this.getMeasurements();if(u.length===0)return;const d=(r=this._singleLaneMeasurements)==null?void 0:r.flat,h=this.options.lanes===1&&d!=null,m=ux(0,u.length-1,h?p=>d[p*2]:p=>Cy(u[p]).start,i);return Cy(u[m])},this.getMaxScrollOffset=()=>{if(!this.scrollElement)return 0;if("scrollHeight"in this.scrollElement)return this.options.horizontal?this.scrollElement.scrollWidth-this.scrollElement.clientWidth:this.scrollElement.scrollHeight-this.scrollElement.clientHeight;{const i=this.scrollElement.document.documentElement;return this.options.horizontal?i.scrollWidth-this.scrollElement.innerWidth:i.scrollHeight-this.scrollElement.innerHeight}},this.getVirtualDistanceFromEnd=()=>Math.max(this.getTotalSize()-this.getSize()-this.getScrollOffset(),0),this.getDistanceFromEnd=()=>Math.max(this.getMaxScrollOffset()-this.getScrollOffset(),0),this.isAtEnd=(i=this.options.scrollEndThreshold)=>this.getDistanceFromEnd()<=i,this.getOffsetForAlignment=(i,r,u=0)=>{if(!this.scrollElement)return 0;const d=this.getSize(),h=this.getScrollOffset();r==="auto"&&(r=i>=h+d?"end":"start"),r==="center"?i+=(u-d)/2:r==="end"&&(i-=d);const m=this.getMaxScrollOffset();return Math.max(Math.min(m,i),0)},this.getOffsetForIndex=(i,r="auto")=>{i=Math.max(0,Math.min(i,this.options.count-1));const u=this.getSize(),d=this.getScrollOffset(),h=this.measurementsCache[i];if(!h)return;if(r==="auto")if(h.end>=d+u-this.options.scrollPaddingEnd)r="end";else if(h.start<=d+this.options.scrollPaddingStart)r="start";else return[d,r];if(r==="end"&&i===this.options.count-1)return[this.getMaxScrollOffset(),r];const m=r==="end"?h.end+this.options.scrollPaddingEnd:h.start-this.options.scrollPaddingStart;return[this.getOffsetForAlignment(m,r,h.size),r]},this.scrollToOffset=(i,{align:r="start",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0;const d=this.getOffsetForAlignment(i,r),h=this.now();this.scrollState={index:null,align:r,behavior:u,startedAt:h,lastTargetOffset:d,stableFrames:0},this._scrollToOffset(d,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollToIndex=(i,{align:r="auto",behavior:u="auto"}={})=>{this._iosDeferredAdjustment=0,i=Math.max(0,Math.min(i,this.options.count-1));const d=this.getOffsetForIndex(i,r);if(!d)return;const[h,m]=d,p=this.now();this.scrollState={index:i,align:m,behavior:u,startedAt:p,lastTargetOffset:h,stableFrames:0},this._scrollToOffset(h,{adjustments:void 0,behavior:u}),this.scheduleScrollReconcile()},this.scrollBy=(i,{behavior:r="auto"}={})=>{const u=this.getScrollOffset()+i,d=this.now();this.scrollState={index:null,align:"start",behavior:r,startedAt:d,lastTargetOffset:u,stableFrames:0},this._scrollToOffset(u,{adjustments:void 0,behavior:r}),this.scheduleScrollReconcile()},this.scrollToEnd=({behavior:i="auto"}={})=>{if(this.options.count>0){this.scrollToIndex(this.options.count-1,{align:"end",behavior:i});return}this.scrollToOffset(Math.max(this.getTotalSize()-this.getSize(),0),{behavior:i})},this.getTotalSize=()=>{var i,r;const u=this.getMeasurements();let d;if(u.length===0)d=this.options.paddingStart;else if(this.options.lanes===1){const h=u.length-1,m=(i=this._singleLaneMeasurements)==null?void 0:i.flat;m!=null?d=m[h*2]+m[h*2+1]:d=((r=u[h])==null?void 0:r.end)??0}else{const h=Array(this.options.lanes).fill(null);let m=u.length-1;for(;m>=0&&h.some(p=>p===null);){const p=u[m];h[p.lane]===null&&(h[p.lane]=p.end),m--}d=Math.max(...h.filter(p=>p!==null))}return Math.max(d-this.options.scrollMargin+this.options.paddingEnd,0)},this.takeSnapshot=()=>{const i=[];if(this.itemSizeCache.size===0)return i;const r=this.getMeasurements();for(const u of r)u&&this.itemSizeCache.has(u.key)&&i.push({index:u.index,key:u.key,start:u.start,size:u.size,end:u.end,lane:u.lane});return i},this._scrollToOffset=(i,{adjustments:r,behavior:u})=>{this._intendedScrollOffset=i+(r??0),this.options.scrollToFn(i,{behavior:u,adjustments:r},this)},this.measure=()=>{this.pendingMin=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.itemSizeCacheVersion++,this.notify(!1)},this.setOptions(s)}applyScrollAdjustment(s,i){if(s===0)return!1;if(lh()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded))return this._iosDeferredAdjustment+=s,!1;{const r=this.getScrollOffset()+this.scrollAdjustments+s,u=this.scrollElement,d=u!==null&&("scrollHeight"in u||"document"in 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n===null?f.jsx("span",{style:{color:"var(--chev)"},children:"–"}):f.jsxs("span",{className:"vbar",children:[f.jsx("span",{className:"vbar-n",children:Oh(n)}),f.jsxs("span",{className:"vbar-track","aria-hidden":!0,children:[f.jsx("span",{className:"vbar-fill",style:{width:`${Math.min(n/s,1)*100}%`}}),i&&f.jsx("span",{className:"vbar-tick",style:{left:`${1/s*100}%`}})]})]})}function CN({variant:n,showDriver:s}){return f.jsxs("span",{className:"flex flex-wrap gap-1.5",children:[s&&n.is_driver&&f.jsx("span",{className:"sc-pill p-neu",children:"Driver"}),n.hotspot&&f.jsx("span",{className:"sc-pill p-hot",children:"Hotspot"}),n.in_dmp&&f.jsx("span",{className:"sc-pill p-dmp",children:"In DMP"}),n.ffpe_removed&&f.jsx("span",{className:"sc-pill p-ffpe",title:"Left out of the report's counts by its FFPE artifact filter",children:"FFPE filtered"})]})}function jN(n){return`${n.ref}>${n.alt}`}function EN({variant:n,onLocate:s}){const[i,r]=E.useState(!1),u=`chr${n.chrom}:${n.pos}`,d=[["Variant",`${n.kind==="snv"?"SNV":n.kind==="indel"?"Indel":n.kind}, ${jN(n)}`],...n.depth!==null?[["Reads",`${n.alt_reads??"?"} of ${n.depth}`]]:[],["Normal VAF",Oh(n.normal_vaf)],["Mutant copies",tj(n.mut_alleles)??"–"],["Consequence",(n.consequence??n.effect??"–").replace(/&/g,", ")],["COSMIC",ej(n.cosmic)??"–"],...n.ffpe_score!==null||n.ffpe_removed?[["FFPE artifact score",n.ffpe_score!==null?Oh(n.ffpe_score):"Not scored"]]:[],["Expression",n.gene_tpm!==null?`${n.gene_tpm.toFixed(1)} TPM`:"–"],["Gene role",nj(n)??"–"]];return f.jsxs("div",{className:"vt-detail-body",children:[f.jsx("dl",{className:"vt-facts",children:d.map(([h,m])=>f.jsxs("div",{children:[f.jsx("dt",{children:h}),f.jsx("dd",{children:m})]},h))}),f.jsxs("div",{className:"flex flex-wrap items-center gap-2",children:[f.jsxs("button",{type:"button",className:"sc-btn sc-b2 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_N({data:n,rows:s,hasMore:i,loadingMore:r,onMore:u,table:d,fetching:h,showCcf:m,onTable:p,onHover:y,onLocate:x}){const[v,b]=E.useState({}),w=d.q,C=d.scope!=="drivers",N=E.useMemo(()=>[{id:"expand",header:()=>f.jsx("span",{className:"sr-only",children:"Details"}),meta:{className:"pin vt-x"},cell:({row:D})=>f.jsx("button",{type:"button",className:"vt-expand","aria-expanded":D.getIsExpanded(),"aria-label":`Details of ${D.original.gene??"this mutation"} ${D.original.protein_change??""}`.trim(),onClick:z=>{z.stopPropagation(),D.toggleExpanded()},onFocus:()=>y(D.original),children:f.jsx(nm,{size:14,"aria-hidden":!0})})},{id:"gene",header:"Gene",meta:{className:"pin vt-g",sorts:[{key:"gene",label:"Gene"},{key:"position",label:"Position"}]},cell:({row:{original:D}})=>f.jsxs(f.Fragment,{children:[f.jsx("span",{className:"vt-gene",children:f.jsx(ds,{text:D.gene??"–",query:w})}),f.jsx("span",{className:"vt-sub 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0,children:_C(D.consequence,D.effect)})},{id:"vaf",header:"VAF",meta:{className:"n",sorts:[{key:"vaf",label:"VAF",descFirst:!0}]},cell:({row:{original:D}})=>f.jsx(Ny,{value:D.vaf,max:1})},...m?[{id:"ccf",header:"CCF",meta:{className:"n",sorts:[{key:"ccf",label:"CCF",descFirst:!0}]},cell:({row:{original:D}})=>f.jsx(Ny,{value:D.ccf,max:1.25,clonal:!0})}]:[],{id:"flags",header:"Flags",cell:({row:{original:D}})=>f.jsx(CN,{variant:D,showDriver:C})}],[w,C,m,y]),M=ox({data:s,columns:N,getRowId:ZC,getCoreRowModel:ix(),getExpandedRowModel:rx(),getRowCanExpand:()=>!0,manualPagination:!0,state:{expanded:v},onExpandedChange:b}),R=d.sort.replace(/^-/,""),j=M.getVisibleLeafColumns().length,F=G1(d)>0,T=E.useRef(null),H=JSON.stringify([d.scope,d.sort,d.q,d.effects,d.flags,d.range,d.ffpe]);return E.useEffect(()=>{T.current&&(T.current.scrollTop=0)},[H]),f.jsxs("div",{className:"flex min-w-0 flex-col",children:[f.jsx("div",{className:"tbar",children:f.jsx($u,{value:d.q,onChange:D=>p({q:D})})}),f.jsxs("div",{ref:T,className:"vt-scroll vt-viewport",onMouseLeave:()=>y(null),"aria-busy":h,children:[h&&f.jsx("div",{className:"vt-progress","aria-hidden":!0}),f.jsxs("table",{className:"vt",children:[f.jsx("thead",{children:M.getHeaderGroups().map(D=>f.jsx("tr",{children:D.headers.map(z=>{var k;const Y=z.column.columnDef.meta,te=(k=Y==null?void 0:Y.sorts)==null?void 0:k.some(ne=>ne.key===R);return f.jsx("th",{className:Y==null?void 0:Y.className,"aria-sort":te?d.sort.startsWith("-")?"descending":"ascending":void 0,children:Y!=null&&Y.sorts?f.jsx("span",{className:"vt-sorts",children:Y.sorts.map(ne=>f.jsx(NN,{sort:ne,current:d.sort,onSort:ie=>p({sort:ie})},ne.key))}):Vu(z.column.columnDef.header,z.getContext())},z.id)})},D.id))}),f.jsx(fx,{items:M.getRowModel().rows,scrollRef:T,columnCount:j,getKey:D=>D.id,onEndReached:i&&!r?u:void 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0:s.lineage),picked:x,className:"mut",info:"mutations",expandable:!0,controls:f.jsx(f.Fragment,{children:f.jsx(Zu,{label:"Which mutations",value:w.scope,onChange:ie=>C({scope:ie,sort:k1[ie]}),options:[{value:"drivers",label:f.jsxs(f.Fragment,{children:["Drivers",f.jsx("span",{className:"seg-n",children:Y(H==null?void 0:H.drivers)})]})},{value:"coding",label:f.jsxs(f.Fragment,{children:["Coding",f.jsx("span",{className:"seg-n",children:Y(H==null?void 0:H.coding)})]})},{value:"all",label:f.jsxs(f.Fragment,{children:["All",f.jsx("span",{className:"seg-n",children:Y(H==null?void 0:H.all)})]})}]})}),children:[f.jsx(uE,{envelope:p,loading:y,measure:v,onMeasure:b,range:te,focus:N,onRange:ie=>{!ie&&!w.range||C({range:ie?{measure:v,low:ie[0],high:ie[1]}:null})},onGene:ie=>C({q:ie})}),T&&s&&s.warnings.length>0&&f.jsx("div",{className:"px-5 py-2 text-xs",role:"note",style:{color:"var(--warn-ink)"},children:s.warnings.join(" ")}),T?f.jsxs("div",{className:"mut-body",children:[f.jsx(dE,{table:w,data:T,onChange:C}),f.jsx(_N,{data:T,rows:i,hasMore:r,loadingMore:u,onMore:d,table:w,fetching:m,showCcf:j,onTable:C,onHover:M,onLocate:R})]}):f.jsx("div",{className:"mut-rule",children:f.jsx(Zr,{label:"mutations",envelope:s,loading:h,skeletonHeight:240,children:()=>null})})]})}),um={oncogene:"Oncogene",tsg:"Tumour suppressor",both:"Oncogene and TSG"},dx=["oncogene","tsg","both"],cm={deletion:"Deletion","tandem-duplication":"Tandem duplication",inversion:"Inversion",translocation:"Translocation"},RN={"<1kb":"<1 kb","1kb-10kb":"1–10 kb","10kb-100kb":"10–100 kb","100kb-1Mb":"100 kb–1 Mb",">1Mb":">1 Mb"};function TN(n){return n?RN[n]??n:""}const AN={DEL:"Deletion",DUP:"Duplication",INV:"Inversion",TRA:"Translocation",BND:"Breakend",INS:"Insertion"};function fm(n){return n?AN[n]??n:"–"}function ON(n){return n==null?"–":n>=1e6?`${(n/1e6).toLocaleString("en-US",{maximumFractionDigits:1})} Mb`:n>=1e3?`${(n/1e3).toLocaleString("en-US",{maximumFractionDigits:1})} kb`:`${n.toLocaleString("en-US")} bp`}function zN(n){return n.some(s=>s.left_expression||s.right_expression||s.expression)}function DN(n){const s={oncogene:0,tsg:0,both:0};for(const i of n)i.role&&(s[i.role]+=1);return s}function HN(n){const s=n.trim().match(Y1);if(!s)return null;const i=Number(s[2].replace(/,/g,"")),r=s[3]?Number(s[3].replace(/,/g,"")):i;return{chrom:s[1].toUpperCase(),start:Math.min(i,r),end:Math.max(i,r)}}function LN(n,s){const i=s.trim().toLowerCase();if(!i)return!0;const r=HN(s);if(r){const u=(d,h)=>(d==null?void 0:d.toUpperCase())===r.chrom&&h!==null&&h>=r.start&&h<=r.end;return u(n.left_chrom,n.left_pos)||u(n.right_chrom,n.right_pos)}return[n.gene,n.left_gene,n.right_gene,n.callers,n.left_loc,n.right_loc,n.sv_type,fm(n.sv_type),n.role?um[n.role]:null].some(u=>u==null?void 0:u.toLowerCase().includes(i))}const Wa={deletion:"var(--sv-del)","tandem-duplication":"var(--sv-dup)",inversion:"var(--sv-inv)",translocation:"var(--sv-tra)"},UN={deletion:"Deletion","tandem-duplication":"Tandem dup.",inversion:"Inversion",translocation:"Transl."},VN={"<1kb":"<1k","1kb-10kb":"10k","10kb-100kb":"100k","100kb-1Mb":"1M",">1Mb":">1M"};function $N(n){return n.size?VN[n.size]??n.size:""}function _y(n){const s=`${n.clustered?"Clustered":"Dispersed"} ${cm[n.sv_class].toLowerCase()}s`;return n.size?`${s}, ${TN(n.size)}`:s}function FN(n){const s=[];return n.forEach((i,r)=>{const u=s[s.length-1];u&&u.clustered===i.clustered&&u.sv_class===i.sv_class?u.end=r:s.push({clustered:i.clustered,sv_class:i.sv_class,start:r,end:r})}),s}function BN(n){const s=new Map;for(const i of n)s.set(i.sv_class,(s.get(i.sv_class)??0)+i.count);return[...s].map(([i,r])=>({sv_class:i,count:r}))}const kN=45;function GN({role:n}){return n?f.jsx("span",{className:`sc-pill p-${n==="oncogene"?"onco":n}`,children:um[n]}):f.jsx("span",{style:{color:"var(--chev)"},children:"–"})}function qN({rows:n,shown:s,onToggle:i}){const r=DN(n);return f.jsx("div",{className:"sv-legend",role:"group","aria-label":"Show rows by gene role",children:dx.filter(u=>r[u]>0).map(u=>f.jsxs("button",{type:"button",className:`sv-legend-item p-${u==="oncogene"?"onco":u}`,"aria-pressed":s.includes(u),onClick:()=>i(u),children:[um[u],f.jsx("span",{className:"sv-legend-n",children:r[u]})]},u))})}function My({gene:n,chrom:s,pos:i,loc:r,query:u}){return f.jsxs(f.Fragment,{children:[f.jsxs("span",{className:"sv-end",children:[f.jsx("span",{className:"vt-gene",children:f.jsx(ds,{text:n||"–",query:u})}),r&&f.jsx("span",{className:"sv-loc",children:r})]}),f.jsx("span",{className:"vt-sub stack mono",children:s&&i!==null?Fr(s,i):"–"})]})}function hx(n){return n?n.replace(/,\s*/g,", "):"–"}function QN({label:n,sorted:s,onClick:i}){return f.jsxs("button",{type:"button",className:"vt-sort","data-active":!!s,onClick:i,title:`Sort by ${n.toLowerCase()}`,children:[n,s==="desc"?f.jsx(zu,{size:12,"aria-hidden":!0}):s==="asc"?f.jsx(N1,{size:12,"aria-hidden":!0}):f.jsx(zu,{size:12,"aria-hidden":!0,className:"vt-sort-idle"})]})}function YN({row:n,onLocate:s}){const[i,r]=E.useState(!1),u=n.left_chrom&&n.left_pos!==null?{chrom:n.left_chrom,pos:n.left_pos}:null,d=n.right_chrom&&n.right_pos!==null?{chrom:n.right_chrom,pos:n.right_pos}:null,h=[["Type",fm(n.sv_type)],["Left breakpoint",u?`${Fr(u.chrom,u.pos)}${n.left_loc?`, ${n.left_loc}`:""}`:"–"],["Right breakpoint",d?`${Fr(d.chrom,d.pos)}${n.right_loc?`, ${n.right_loc}`:""}`:"–"],["Pileups (left, right)",[n.left_pileup,n.right_pileup].filter(Boolean).join(", ")||"–"],["Orientation",n.orientation??"–"],["Callers",hx(n.callers)]],m=n.gene??n.left_gene,p=n.gene??n.right_gene;return f.jsxs("div",{className:"vt-detail-body",children:[f.jsx("dl",{className:"vt-facts",children:h.map(([y,x])=>f.jsxs("div",{children:[f.jsx("dt",{children:y}),f.jsx("dd",{children:x})]},y))}),f.jsxs("div",{className:"flex flex-wrap items-center gap-2",children:[u&&f.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:()=>s({...u,gene:m}),children:[f.jsx(Ah,{size:14,"aria-hidden":!0}),"Show ",d&&d.chrom===u.chrom?"it":"left breakpoint"," on copy number"]}),d&&d.chrom!==(u==null?void 0:u.chrom)&&f.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:()=>s({...d,gene:p}),children:[f.jsx(Ah,{size:14,"aria-hidden":!0}),"Show right breakpoint on copy number"]}),n.igv_locus&&f.jsxs("button",{type:"button",className:"sc-btn sc-b2 sm",onClick:async()=>{try{await navigator.clipboard.writeText(n.igv_locus??""),r(!0),window.setTimeout(()=>r(!1),1500)}catch{window.prompt("Copy these IGV loci",n.igv_locus??"")}},children:[f.jsx(R1,{size:14,"aria-hidden":!0}),i?"Copied":"Copy IGV loci"]})]})]})}function Ry({kind:n,rows:s,total:i=s.length,query:r="",onLocate:u}){const[d,h]=E.useState({}),[m,p]=E.useState([]),y=E.useRef(null),x=zN(s);E.useEffect(()=>{y.current&&(y.current.scrollTop=0)},[r,s.length]);const v=E.useMemo(()=>{const N={id:"expand",header:()=>f.jsx("span",{className:"sr-only",children:"Details"}),enableSorting:!1,meta:{className:"pin vt-x"},cell:({row:j})=>f.jsx("button",{type:"button",className:"vt-expand","aria-expanded":j.getIsExpanded(),"aria-label":`Details of ${j.original.gene??[j.original.left_gene,j.original.right_gene].filter(Boolean).join(" and 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")||"–"})}],R=x?[{id:"expression",header:"Expression",enableSorting:!1,cell:({row:{original:j}})=>n==="whole_gene"?f.jsx("span",{className:"text-[12.5px]",children:j.expression??"–"}):f.jsxs("span",{className:"flex flex-col text-[12.5px] leading-snug",children:[f.jsx("span",{children:j.left_expression??"–"}),f.jsx("span",{style:{color:"var(--muted)"},children:j.right_expression??"–"})]})}]:[];return n==="whole_gene"?[N,{id:"gene",header:"Gene",accessorFn:j=>j.gene??"",meta:{className:"pin vt-g"},cell:({row:{original:j}})=>f.jsxs(f.Fragment,{children:[f.jsx("span",{className:"vt-gene",children:f.jsx(ds,{text:j.gene??"–",query:r})}),f.jsx("span",{className:"vt-sub 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