wgts-report 0.1.13 → 0.1.15

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Files changed (4) hide show
  1. package/dist/assets/wgts-report.css +1 -1
  2. package/dist/assets/wgts-report.js +85 -60
  3. package/dist/index.html +2 -2
  4. package/package.json +1 -1
package/dist/assets/wgts-report.js CHANGED
@@ -1,4 +1,4 @@
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  * @license React
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  *
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  *
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  * This source code is licensed under the MIT license found in the
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i=t.pendingProps,u=!1,f=(t.flags&128)!==0,p;if((p=f)||(p=e!==null&&e.memoizedState===null?!1:(Ht.current&2)!==0),p&&(u=!0,t.flags&=-129),p=(t.flags&32)!==0,t.flags&=-33,e===null){if(Oe){if(u?dl(t):hl(),(e=st)?(e=iv(e,Bn),e=e!==null&&e.data!=="&"?e:null,e!==null&&(t.memoizedState={dehydrated:e,treeContext:sl!==null?{id:fs,overflow:ds}:null,retryLane:536870912,hydrationErrors:null},s=yp(e),s.return=t,t.child=s,_t=t,st=null)):e=null,e===null)throw al(t);return uh(e)?t.lanes=32:t.lanes=536870912,null}return f=i.children,i=i.fallback,u?(hl(),u=t.mode,f=zc({mode:"hidden",children:f},u),i=ea(i,u,s,null),f.return=t,i.return=t,f.sibling=i,t.child=f,i=t.child,i.memoizedState=ud(s),i.childLanes=fd(e,p,s),t.memoizedState=cd,Bo(null,i)):(dl(t),dd(t,f))}var w=e.memoizedState;if(w!==null){var z=w.dehydrated;if(z!==null)return aj(e,t,f,p,i,z,w,s)}return 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0&&(this.setState(Kv(a.data,a.dataUpdatedAt)),he(this,Ma,a))}}optionalRemove(){!this.observers.length&&this.state.fetchStatus==="idle"&&F(this,Qn).remove(this)}setData(l,a){const o=xm(this.state.data,l,this.options);return ke(this,ss,Qs).call(this,{data:o,type:"success",dataUpdatedAt:a==null?void 0:a.updatedAt,manual:a==null?void 0:a.manual}),o}setState(l){ke(this,ss,Qs).call(this,{type:"setState",state:l})}cancel(l){var o,c;const a=(o=F(this,Et))==null?void 0:o.promise;return(c=F(this,Et))==null||c.cancel(l),a?a.then(Sn).catch(Sn):Promise.resolve()}destroy(){super.destroy(),this.cancel({silent:!0})}get resetState(){return F(this,Ma)}reset(){this.destroy(),this.setState(this.resetState)}isActive(){return this.observers.some(l=>rt(l.options.enabled,this)!==!1)}isDisabled(){return this.getObserversCount()>0?!this.isActive():this.options.queryFn===ag||!this.isFetched()}isFetched(){return this.state.dataUpdateCount+this.state.errorUpdateCount>0}isStatic(){return this.getObserversCount()>0?this.observers.some(l=>rt(l.options.staleTime,this)==="static"):!1}isStale(){return this.getObserversCount()>0?this.observers.some(l=>l.getCurrentResult().isStale):this.state.data===void 0||this.state.isInvalidated}isStaleByTime(l=0){return this.state.data===void 0?!0:l==="static"?!1:this.state.isInvalidated?!0:!p1(this.state.dataUpdatedAt,l)}onFocus(){var l,a;(l=this.observers.find(o=>o.shouldFetchOnWindowFocus()))==null||l.refetch({cancelRefetch:!1}),(a=F(this,Et))==null||a.continue()}onOnline(){var l,a;(l=this.observers.find(o=>o.shouldFetchOnReconnect()))==null||l.refetch({cancelRefetch:!1}),(a=F(this,Et))==null||a.continue()}addObserver(l){this.observers.includes(l)||(this.observers.push(l),this.clearGcTimeout(),F(this,Qn).notify({type:"observerAdded",query:this,observer:l}))}removeObserver(l){const a=this.observers.indexOf(l);a!==-1&&(this.observers.splice(a,1),this.observers.length||(F(this,Et)&&(F(this,Ta)||this.state.fetchStatus==="paused"&&this.state.status==="pending"?F(this,Et).cancel({revert:!0}):F(this,Et).cancelRetry()),this.scheduleGc()),F(this,Qn).notify({type:"observerRemoved",query:this,observer:l}))}getObserversCount(){return this.observers.length}invalidate(){this.state.isInvalidated||ke(this,ss,Qs).call(this,{type:"invalidate"})}async fetch(l,a){var x,v,y,S,j,b,N,T,O,_,D,C;if(this.state.fetchStatus!=="idle"&&((x=F(this,Et))==null?void 0:x.status())!=="rejected"){if(this.state.data!==void 0&&(a!=null&&a.cancelRefetch))this.cancel({silent:!0});else if(F(this,Et))return F(this,Et).continueRetry(),F(this,Et).promise}if(l&&this.setOptions(l),!this.options.queryFn){const E=this.observers.find(R=>R.options.queryFn);E&&this.setOptions(E.options)}const o=new AbortController,c=E=>{Object.defineProperty(E,"signal",{enumerable:!0,get:()=>(he(this,Ta,!0),o.signal)})},d=()=>{const E=v1(this.options,a),A=(()=>{const B={client:F(this,Ea),queryKey:this.queryKey,meta:this.meta};return c(B),B})();return he(this,Ta,!1),this.options.persister?this.options.persister(E,A,this):E(A)},m=(()=>{const E={fetchOptions:a,options:this.options,queryKey:this.queryKey,client:F(this,Ea),state:this.state,fetchFn:d};return c(E),E})();(v=F(this,Zi)==="infinite"?lw(this.options.pages):this.options.behavior)==null||v.onFetch(m,this),he(this,Ji,this.state),(this.state.fetchStatus==="idle"||this.state.fetchMeta!==((y=m.fetchOptions)==null?void 0:y.meta))&&ke(this,ss,Qs).call(this,{type:"fetch",meta:(S=m.fetchOptions)==null?void 0:S.meta});const g=he(this,Et,b1({initialPromise:a==null?void 0:a.initialPromise,fn:m.fetchFn,onCancel:E=>{E instanceof 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ke(this,ss,Qs).call(this,{type:"error",error:E}),(_=(O=F(this,Qn).config).onError)==null||_.call(O,E,this),(C=(D=F(this,Qn).config).onSettled)==null||C.call(D,this.state.data,E,this),E}finally{F(this,Et)===g&&he(this,Et,void 0),this.scheduleGc()}}},Zi=new WeakMap,Ma=new WeakMap,Ji=new WeakMap,Qn=new WeakMap,Ea=new WeakMap,Et=new WeakMap,zr=new WeakMap,Ta=new WeakMap,ss=new WeakSet,Qs=function(l){const a=o=>{switch(l.type){case"failed":return{...o,fetchFailureCount:l.failureCount,fetchFailureReason:l.error};case"pause":return{...o,fetchStatus:"paused"};case"continue":return{...o,fetchStatus:"fetching"};case"fetch":return{...o,...N1(o.data,this.options),fetchMeta:l.meta??null};case"success":const c={...o,...Kv(l.data,l.dataUpdatedAt),dataUpdateCount:o.dataUpdateCount+1,...!l.manual&&{fetchStatus:"idle",fetchFailureCount:0,fetchFailureReason:null}};return he(this,Ji,l.manual?c:void 0),c;case"error":const d=l.error;return{...o,error:d,errorUpdateCount:o.errorUpdateCount+1,errorUpdatedAt:Date.now(),fetchFailureCount:o.fetchFailureCount+1,fetchFailureReason:d,fetchStatus:"idle",status:"error",isInvalidated:!0};case"invalidate":return{...o,isInvalidated:!0};case"setState":return{...o,...l.state}}};this.state=a(this.state),Bt.batch(()=>{this.observers.slice().forEach(o=>{o.onQueryUpdate()}),F(this,Qn).notify({query:this,type:"updated",action:l})})},i1);function N1(n,l){return{fetchFailureCount:0,fetchFailureReason:null,fetchStatus:S1(l.networkMode)?"fetching":"paused",...n===void 0&&{error:null,status:"pending"}}}function Kv(n,l){return{data:n,dataUpdatedAt:l??Date.now(),error:null,isInvalidated:!1,status:"success"}}function Zv(n){const l=typeof n.initialData=="function"?n.initialData():n.initialData,a=l!==void 0,o=a?typeof n.initialDataUpdatedAt=="function"?n.initialDataUpdatedAt():n.initialDataUpdatedAt:0;return{data:l,dataUpdateCount:0,dataUpdatedAt:a?o??Date.now():0,error:null,errorUpdateCount:0,errorUpdatedAt:0,fetchFailureCount:0,fetchFailureReason:null,fetchMeta:null,isInvalidated:!1,status:a?"success":"pending",fetchStatus:"idle"}}var cn,Fe,Dr,un,_a,Wi,Xs,Lr,eo,to,Ra,Aa,Dl,no,Ye,br,jm,wm,Nm,Cm,Mm,Em,Tm,_m,o1,C1=(o1=class extends Hr{constructor(l,a){super();Ne(this,Ye);Ne(this,cn);Ne(this,Fe);Ne(this,Dr);Ne(this,un);Ne(this,_a);Ne(this,Wi);Ne(this,Xs);Ne(this,Lr);Ne(this,eo);Ne(this,to);Ne(this,Ra);Ne(this,Aa);Ne(this,Dl);Ne(this,no,new Set);this.options=a,he(this,cn,l),he(this,Xs,null),this.bindMethods(),this.setOptions(a)}bindMethods(){this.refetch=this.refetch.bind(this)}onSubscribe(){this.listeners.size===1&&(F(this,Fe).addObserver(this),Jv(F(this,Fe),this.options)?ke(this,Ye,br).call(this):this.updateResult(),ke(this,Ye,Mm).call(this))}onUnsubscribe(){this.hasListeners()||this.destroy()}shouldFetchOnReconnect(){return Rm(F(this,Fe),this.options,this.options.refetchOnReconnect)}shouldFetchOnWindowFocus(){return Rm(F(this,Fe),this.options,this.options.refetchOnWindowFocus)}destroy(){this.listeners=new Set,ke(this,Ye,Em).call(this),ke(this,Ye,Tm).call(this),F(this,Fe).removeObserver(this)}setOptions(l){const a=this.options,o=F(this,Fe);if(this.options=F(this,cn).defaultQueryOptions(l),this.options.enabled!==void 0&&typeof this.options.enabled!="boolean"&&typeof this.options.enabled!="function"&&typeof rt(this.options.enabled,F(this,Fe))!="boolean")throw new Error("Expected enabled to be a boolean or a callback that 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Proxy(l,{get:(o,c)=>(this.trackProp(c),a==null||a(c),Reflect.get(o,c))})}trackProp(l){F(this,no).add(l)}getCurrentQuery(){return F(this,Fe)}refetch({...l}={}){return this.fetch({...l})}fetchOptimistic(l){const a=F(this,cn).defaultQueryOptions(l),o=F(this,cn).getQueryCache().build(F(this,cn),a);let c=()=>{},d;const h=new Promise(m=>{d=m,c=F(this,cn).getQueryCache().subscribe(g=>{g.type==="updated"&&g.query.queryHash===o.queryHash&&o.state.data!==void 0&&(c(),m(this.createResult(o,a)))})});return Promise.race([o.fetch(a).then(()=>{const m=this.createResult(o,a);return d==null||d(m),m}).finally(()=>{c()}),h])}fetch(l){return ke(this,Ye,br).call(this,{...l,cancelRefetch:l.cancelRefetch??!0}).then(()=>(this.updateResult(),F(this,un)))}createResult(l,a){var R;const o=F(this,Fe),c=this.options,d=F(this,un),h=F(this,_a),m=F(this,Wi),g=l!==o?l.state:F(this,Dr),{state:x}=l;let v={...x},y=!1,S;if(a._optimisticResults){const A=this.hasListeners(),B=!A&&Jv(l,a),K=A&&Wv(l,o,a,c);(B||K)&&(v={...v,...N1(x.data,l.options)}),a._optimisticResults==="isRestoring"&&(v.fetchStatus="idle")}let{error:j,errorUpdatedAt:b,status:N}=v;S=v.data;let T=!1;if(a.placeholderData!==void 0&&S===void 0&&N==="pending"){let A;d!=null&&d.isPlaceholderData&&a.placeholderData===(m==null?void 0:m.placeholderData)?(A=d.data,T=!0):A=typeof a.placeholderData=="function"?a.placeholderData((R=F(this,to))==null?void 0:R.state.data,F(this,to)):a.placeholderData,A!==void 0&&(N="success",S=xm(d==null?void 0:d.data,A,a),y=!0)}if(a.select&&S!==void 0&&!T)if(d&&S===(h==null?void 0:h.data)&&a.select===F(this,Lr))S=F(this,eo);else try{he(this,Lr,a.select),S=a.select(S),S=xm(d==null?void 0:d.data,S,a),he(this,eo,S),he(this,Xs,null)}catch(A){he(this,Xs,A)}else S===void 0&&he(this,Xs,null);F(this,Xs)&&(j=F(this,Xs),S=F(this,eo),b=Date.now(),N="error",y=!1);const O=v.fetchStatus==="fetching",_=N==="pending",D=N==="error",C=_&&O,E=S!==void 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this.options.throwOnError&&m.add("error"),Object.keys(F(this,un)).some(g=>{const x=g;return F(this,un)[x]!==l[x]&&m.has(x)})})();Bt.batch(()=>{c&&this.listeners.forEach(d=>{d(F(this,un))}),F(this,cn).getQueryCache().notify({query:F(this,Fe),type:"observerResultsUpdated"})})}onQueryUpdate(){this.updateResult(),this.hasListeners()&&ke(this,Ye,Mm).call(this)}},cn=new WeakMap,Fe=new WeakMap,Dr=new WeakMap,un=new WeakMap,_a=new WeakMap,Wi=new WeakMap,Xs=new WeakMap,Lr=new WeakMap,eo=new WeakMap,to=new WeakMap,Ra=new WeakMap,Aa=new WeakMap,Dl=new WeakMap,no=new WeakMap,Ye=new WeakSet,br=function(l){ke(this,Ye,_m).call(this);let a=F(this,Fe).fetch(this.options,l);return l!=null&&l.throwOnError||(a=a.catch(Sn)),a},jm=function(l){return!ig()&&rt(this.options.enabled,F(this,Fe))!==!1&&g1(l)},wm=function(){ke(this,Ye,Em).call(this);const l=rt(this.options.staleTime,F(this,Fe));if(F(this,un).isStale||!ke(this,Ye,jm).call(this,l))return;const a=p1(F(this,un).dataUpdatedAt,l)+1;he(this,Ra,ja.setTimeout(()=>{F(this,un).isStale||this.updateResult()},a))},Nm=function(){return rt(this.options.refetchInterval,F(this,Fe))??!1},Cm=function(l){ke(this,Ye,Tm).call(this),he(this,Dl,l),!(F(this,Dl)===0||!ke(this,Ye,jm).call(this,F(this,Dl)))&&he(this,Aa,ja.setInterval(()=>{(this.options.refetchIntervalInBackground||og.isFocused())&&ke(this,Ye,br).call(this)},F(this,Dl)))},Mm=function(){ke(this,Ye,wm).call(this),ke(this,Ye,Cm).call(this,ke(this,Ye,Nm).call(this))},Em=function(){F(this,Ra)!==void 0&&(ja.clearTimeout(F(this,Ra)),he(this,Ra,void 0))},Tm=function(){F(this,Aa)!==void 0&&(ja.clearInterval(F(this,Aa)),he(this,Aa,void 0))},_m=function(){const l=F(this,cn).getQueryCache().build(F(this,cn),this.options);if(l===F(this,Fe))return;const a=F(this,Fe);he(this,Fe,l),he(this,Dr,l.state),this.hasListeners()&&(a==null||a.removeObserver(this),l.addObserver(this))},o1);function rw(n,l){return rt(l.enabled,n)!==!1&&n.state.data===void 0&&!(n.state.status==="error"&&rt(l.retryOnMount,n)===!1)}function Jv(n,l){return rw(n,l)||n.state.data!==void 0&&Rm(n,l,l.refetchOnMount)}function Rm(n,l,a){if(rt(l.enabled,n)!==!1&&rt(l.staleTime,n)!=="static"){const o=rt(a,n);return o==="always"||o!==!1&&rg(n,l)}return!1}function Wv(n,l,a,o){return(n!==l||rt(o.enabled,n)===!1)&&(!a.suspense||n.state.status!=="error")&&rg(n,a)}function rg(n,l){return rt(l.enabled,n)!==!1&&n.isStaleByTime(rt(l.staleTime,n))}var cw=class extends C1{constructor(n,l){super(n,l)}bindMethods(){super.bindMethods(),this.fetchNextPage=this.fetchNextPage.bind(this),this.fetchPreviousPage=this.fetchPreviousPage.bind(this)}setOptions(n){n._type="infinite",super.setOptions(n)}getOptimisticResult(n){return n._type="infinite",super.getOptimisticResult(n)}fetchNextPage(n){return this.fetch({...n,meta:{fetchMore:{direction:"forward"}}})}fetchPreviousPage(n){return this.fetch({...n,meta:{fetchMore:{direction:"backward"}}})}createResult(n,l){var j,b;const{state:a}=n,o=super.createResult(n,l),{isFetching:c,isRefetching:d,isError:h,isRefetchError:m}=o,g=(b=(j=a.fetchMeta)==null?void 0:j.fetchMore)==null?void 0:b.direction,x=h&&g==="forward",v=c&&g==="forward",y=h&&g==="backward",S=c&&g==="backward";return{...o,fetchNextPage:this.fetchNextPage,fetchPreviousPage:this.fetchPreviousPage,hasNextPage:aw(l,a.data),hasPreviousPage:iw(l,a.data),isFetchNextPageError:x,isFetchingNextPage:v,isFetchPreviousPageError:y,isFetchingPreviousPage:S,isRefetchError:m&&!x&&!y,isRefetching:d&&!v&&!S}}},$r,bs,Kt,Oa,js,Tl,r1,uw=(r1=class extends j1{constructor(l){super();Ne(this,js);Ne(this,$r);Ne(this,bs);Ne(this,Kt);Ne(this,Oa);he(this,$r,l.client),this.mutationId=l.mutationId,he(this,Kt,l.mutationCache),he(this,bs,[]),this.state=l.state||fw(),this.setOptions(l.options),this.scheduleGc()}setOptions(l){this.options=l,this.updateGcTime(this.options.gcTime)}get meta(){return this.options.meta}addObserver(l){F(this,bs).includes(l)||(F(this,bs).push(l),this.clearGcTimeout(),F(this,Kt).notify({type:"observerAdded",mutation:this,observer:l}))}removeObserver(l){he(this,bs,F(this,bs).filter(a=>a!==l)),this.scheduleGc(),F(this,Kt).notify({type:"observerRemoved",mutation:this,observer:l})}optionalRemove(){F(this,bs).length||(this.state.status==="pending"?this.scheduleGc():F(this,Kt).remove(this))}continue(){var l;return((l=F(this,Oa))==null?void 0:l.continue())??(this.state.status==="pending"?this.execute(this.state.variables):Promise.resolve())}async execute(l){var m,g,x,v,y,S,j,b,N,T,O,_,D,C,E,R,A,B;const a=()=>{ke(this,js,Tl).call(this,{type:"continue"})},o={client:F(this,$r),meta:this.options.meta,mutationKey:this.options.mutationKey},c=he(this,Oa,b1({fn:()=>this.options.mutationFn?this.options.mutationFn(l,o):Promise.reject(new Error("No mutationFn found")),onFail:(K,k)=>{ke(this,js,Tl).call(this,{type:"failed",failureCount:K,error:k})},onPause:()=>{ke(this,js,Tl).call(this,{type:"pause"})},onContinue:a,retry:this.options.retry??0,retryDelay:this.options.retryDelay,networkMode:this.options.networkMode,canRun:()=>F(this,Kt).canRun(this)})),d=this.state.status==="pending",h=!c.canStart();try{if(d)a();else{ke(this,js,Tl).call(this,{type:"pending",variables:l,isPaused:h}),F(this,Kt).config.onMutate&&await F(this,Kt).config.onMutate(l,this,o);const k=await((g=(m=this.options).onMutate)==null?void 0:g.call(m,l,o));k!==this.state.context&&ke(this,js,Tl).call(this,{type:"pending",context:k,variables:l,isPaused:h})}const K=await c.start();return await((v=(x=F(this,Kt).config).onSuccess)==null?void 0:v.call(x,K,l,this.state.context,this,o)),await((S=(y=this.options).onSuccess)==null?void 0:S.call(y,K,l,this.state.context,o)),await((b=(j=F(this,Kt).config).onSettled)==null?void 0:b.call(j,K,null,this.state.variables,this.state.context,this,o)),await((T=(N=this.options).onSettled)==null?void 0:T.call(N,K,null,l,this.state.context,o)),ke(this,js,Tl).call(this,{type:"success",data:K}),K}catch(K){try{await((_=(O=F(this,Kt).config).onError)==null?void 0:_.call(O,K,l,this.state.context,this,o))}catch(k){Promise.reject(k)}try{await((C=(D=this.options).onError)==null?void 0:C.call(D,K,l,this.state.context,o))}catch(k){Promise.reject(k)}try{await((R=(E=F(this,Kt).config).onSettled)==null?void 0:R.call(E,void 0,K,this.state.variables,this.state.context,this,o))}catch(k){Promise.reject(k)}try{await((B=(A=this.options).onSettled)==null?void 0:B.call(A,void 0,K,l,this.state.context,o))}catch(k){Promise.reject(k)}throw ke(this,js,Tl).call(this,{type:"error",error:K}),K}finally{F(this,Oa)===c&&he(this,Oa,void 0),F(this,Kt).runNext(this)}}},$r=new WeakMap,bs=new WeakMap,Kt=new WeakMap,Oa=new WeakMap,js=new WeakSet,Tl=function(l){const a=o=>{switch(l.type){case"failed":return{...o,failureCount:l.failureCount,failureReason:l.error};case"pause":return{...o,isPaused:!0};case"continue":return{...o,isPaused:!1};case"pending":return{...o,context:l.context,data:void 0,failureCount:0,failureReason:null,error:null,isPaused:l.isPaused,status:"pending",variables:l.variables,submittedAt:Date.now()};case"success":return{...o,data:l.data,failureCount:0,failureReason:null,error:null,status:"success",isPaused:!1};case"error":return{...o,data:void 0,error:l.error,failureCount:o.failureCount+1,failureReason:l.error,isPaused:!1,status:"error"}}};this.state=a(this.state),Bt.batch(()=>{F(this,bs).forEach(o=>{o.onMutationUpdate(l)}),F(this,Kt).notify({mutation:this,type:"updated",action:l})})},r1);function fw(){return{context:void 0,data:void 0,error:null,failureCount:0,failureReason:null,isPaused:!1,status:"idle",variables:void 0,submittedAt:0}}var Ll,ls,kr,c1,dw=(c1=class extends Hr{constructor(l={}){super();Ne(this,Ll);Ne(this,ls);Ne(this,kr);this.config=l,he(this,Ll,new Set),he(this,ls,new Map),he(this,kr,0)}build(l,a,o){const c=new uw({client:l,mutationCache:this,mutationId:++gu(this,kr)._,options:l.defaultMutationOptions(a),state:o});return this.add(c),c}add(l){F(this,Ll).add(l);const a=pu(l);if(typeof a=="string"){const o=F(this,ls).get(a);o?o.push(l):F(this,ls).set(a,[l])}this.notify({type:"added",mutation:l})}remove(l){if(F(this,Ll).delete(l)){const a=pu(l);if(typeof a=="string"){const o=F(this,ls).get(a);if(o)if(o.length>1){const c=o.indexOf(l);c!==-1&&o.splice(c,1)}else o[0]===l&&F(this,ls).delete(a)}}this.notify({type:"removed",mutation:l})}canRun(l){var o;const a=pu(l);if(typeof a=="string"){const c=(o=F(this,ls).get(a))==null?void 0:o.find(d=>d.state.status==="pending");return!c||c===l}else return!0}runNext(l){var o,c;const a=pu(l);return typeof a=="string"?((c=(o=F(this,ls).get(a))==null?void 0:o.find(d=>d!==l&&d.state.isPaused))==null?void 0:c.continue())??Promise.resolve():Promise.resolve()}clear(){Bt.batch(()=>{const l=this.getAll();F(this,Ll).clear(),F(this,ls).clear(),l.forEach(a=>{this.notify({type:"removed",mutation:a})})})}getAll(){return Array.from(F(this,Ll))}find(l){const a={exact:!0,...l};return this.getAll().find(o=>Yv(a,o))}findAll(l={}){return this.getAll().filter(a=>Yv(l,a))}notify(l){Bt.batch(()=>{this.listeners.forEach(a=>{a(l)})})}resumePausedMutations(){const l=this.getAll().filter(a=>a.state.isPaused);return Bt.batch(()=>Promise.all(l.map(a=>a.continue().catch(Sn))))}},Ll=new WeakMap,ls=new WeakMap,kr=new WeakMap,c1);function pu(n){var l;return(l=n.options.scope)==null?void 0:l.id}var ws,u1,hw=(u1=class extends Hr{constructor(l={}){super();Ne(this,ws);this.config=l,he(this,ws,new Map)}build(l,a,o){const c=a.queryKey,d=a.queryHash??sg(c,a);let h=this.get(d);return h||(h=new ow({client:l,queryKey:c,queryHash:d,options:l.defaultQueryOptions(a),state:o,defaultOptions:l.getQueryDefaults(c)}),this.add(h)),h}add(l){F(this,ws).has(l.queryHash)||(F(this,ws).set(l.queryHash,l),this.notify({type:"added",query:l}))}remove(l){F(this,ws).get(l.queryHash)===l&&(l.destroy(),F(this,ws).delete(l.queryHash),this.notify({type:"removed",query:l}))}clear(){Bt.batch(()=>{this.getAll().forEach(l=>{this.remove(l)})})}get(l){return F(this,ws).get(l)}getAll(){return[...F(this,ws).values()]}find(l){const a={exact:!0,...l};return this.getAll().find(o=>Qv(a,o))}findAll(l={}){const a=this.getAll();return Object.keys(l).length>0?a.filter(o=>Qv(l,o)):a}notify(l){Bt.batch(()=>{this.listeners.forEach(a=>{a(l)})})}onFocus(){Bt.batch(()=>{this.getAll().forEach(l=>{l.onFocus()})})}onOnline(){Bt.batch(()=>{this.getAll().forEach(l=>{l.onOnline()})})}},ws=new WeakMap,u1),dt,$l,kl,so,lo,Hl,ao,io,f1,mw=(f1=class{constructor(n={}){Ne(this,dt);Ne(this,$l);Ne(this,kl);Ne(this,so);Ne(this,lo);Ne(this,Hl);Ne(this,ao);Ne(this,io);he(this,dt,n.queryCache||new hw),he(this,$l,n.mutationCache||new dw),he(this,kl,n.defaultOptions||{}),he(this,so,new Map),he(this,lo,new Map),he(this,Hl,0)}mount(){gu(this,Hl)._++,F(this,Hl)===1&&(he(this,ao,og.subscribe(async n=>{n&&(await this.resumePausedMutations(),F(this,dt).onFocus())})),he(this,io,Eu.subscribe(async n=>{n&&(await this.resumePausedMutations(),F(this,dt).onOnline())})))}unmount(){var n,l;gu(this,Hl)._--,F(this,Hl)===0&&((n=F(this,ao))==null||n.call(this),he(this,ao,void 0),(l=F(this,io))==null||l.call(this),he(this,io,void 0))}isFetching(n){return F(this,dt).findAll({...n,fetchStatus:"fetching"}).length}isMutating(n){return F(this,$l).findAll({...n,status:"pending"}).length}getQueryData(n){var a;const l=this.defaultQueryOptions({queryKey:n});return(a=F(this,dt).get(l.queryHash))==null?void 0:a.state.data}ensureQueryData(n){const l=this.defaultQueryOptions(n),a=F(this,dt).build(this,l),o=a.state.data;return o===void 0?this.fetchQuery(n):(n.revalidateIfStale&&a.isStaleByTime(rt(l.staleTime,a))&&this.prefetchQuery(l),Promise.resolve(o))}getQueriesData(n){return F(this,dt).findAll(n).map(({queryKey:l,state:a})=>[l,a.data])}setQueryData(n,l,a){var h;const o=this.defaultQueryOptions({queryKey:n}),c=(h=F(this,dt).get(o.queryHash))==null?void 0:h.state.data,d=Q2(l,c);if(d!==void 0)return F(this,dt).build(this,o).setData(d,{...a,manual:!0})}setQueriesData(n,l,a){return Bt.batch(()=>F(this,dt).findAll(n).map(({queryKey:o})=>[o,this.setQueryData(o,l,a)]))}getQueryState(n){var a;const l=this.defaultQueryOptions({queryKey:n});return(a=F(this,dt).get(l.queryHash))==null?void 0:a.state}removeQueries(n){const l=F(this,dt);Bt.batch(()=>{l.findAll(n).forEach(a=>{l.remove(a)})})}resetQueries(n,l){const a=F(this,dt);return Bt.batch(()=>{const o=a.findAll(n),c=new Set(o);return o.forEach(d=>{d.reset()}),this.refetchQueries({type:"active",predicate:d=>c.has(d)},l)})}cancelQueries(n,l={}){const a={revert:!0,...l},o=Bt.batch(()=>F(this,dt).findAll(n).map(c=>c.cancel(a)));return Promise.all(o).then(Sn).catch(Sn)}invalidateQueries(n,l={}){return Bt.batch(()=>(F(this,dt).findAll(n).forEach(a=>{a.invalidate()}),(n==null?void 0:n.refetchType)==="none"?Promise.resolve():this.refetchQueries({...n,type:(n==null?void 0:n.refetchType)??(n==null?void 0:n.type)??"active"},l)))}refetchQueries(n,l={}){const a={...l,cancelRefetch:l.cancelRefetch??!0},o=Bt.batch(()=>F(this,dt).findAll(n).filter(c=>!c.isDisabled()&&!c.isStatic()).map(c=>{let d=c.fetch(void 0,a);return a.throwOnError||(d=d.catch(Sn)),c.state.fetchStatus==="paused"?Promise.resolve():d}));return Promise.all(o).then(Sn)}async query(n){const l=this.defaultQueryOptions(n);l.retry===void 0&&(l.retry=!1);const a=F(this,dt).build(this,l),o=a.isStaleByTime(rt(l.staleTime,a))?await a.fetch(l):a.state.data,c=l.select;return c?c(o):o}fetchQuery(n){const l=this.defaultQueryOptions(n);l.retry===void 0&&(l.retry=!1);const a=F(this,dt).build(this,l);return a.isStaleByTime(rt(l.staleTime,a))?a.fetch(l):Promise.resolve(a.state.data)}prefetchQuery(n){return this.fetchQuery(n).then(Sn).catch(Sn)}infiniteQuery(n){return n._type="infinite",this.query(n)}fetchInfiniteQuery(n){return n._type="infinite",this.fetchQuery(n)}prefetchInfiniteQuery(n){return this.fetchInfiniteQuery(n).then(Sn).catch(Sn)}ensureInfiniteQueryData(n){return n._type="infinite",this.ensureQueryData(n)}resumePausedMutations(){return Eu.isOnline()?F(this,$l).resumePausedMutations():Promise.resolve()}getQueryCache(){return F(this,dt)}getMutationCache(){return F(this,$l)}getDefaultOptions(){return F(this,kl)}setDefaultOptions(n){he(this,kl,n)}setQueryDefaults(n,l){F(this,so).set(Er(n),{queryKey:n,defaultOptions:l})}getQueryDefaults(n){const l=[...F(this,so).values()],a={};return l.forEach(o=>{oo(n,o.queryKey)&&Object.assign(a,o.defaultOptions)}),a}setMutationDefaults(n,l){F(this,lo).set(Er(n),{mutationKey:n,defaultOptions:l})}getMutationDefaults(n){const l=[...F(this,lo).values()],a={};return l.forEach(o=>{oo(n,o.mutationKey)&&Object.assign(a,o.defaultOptions)}),a}defaultQueryOptions(n){if(n._defaulted)return n;const l={...F(this,kl).queries,...this.getQueryDefaults(n.queryKey),...n,_defaulted:!0};return l.queryHash||(l.queryHash=sg(l.queryKey,l)),l.refetchOnReconnect===void 0&&(l.refetchOnReconnect=l.networkMode!=="always"),l.throwOnError===void 0&&(l.throwOnError=!!l.suspense),!l.networkMode&&l.persister&&(l.networkMode="offlineFirst"),l.queryFn===ag&&(l.enabled=!1),l}defaultMutationOptions(n){return n!=null&&n._defaulted?n:{...F(this,kl).mutations,...(n==null?void 0:n.mutationKey)&&this.getMutationDefaults(n.mutationKey),...n,_defaulted:!0}}clear(){F(this,dt).clear(),F(this,$l).clear()}},dt=new WeakMap,$l=new WeakMap,kl=new WeakMap,so=new WeakMap,lo=new WeakMap,Hl=new WeakMap,ao=new WeakMap,io=new WeakMap,f1);const M1=M.createContext(!1),gw=()=>M.useContext(M1);M1.Provider;function pw(){let n=!1;return{clearReset:()=>{n=!1},reset:()=>{n=!0},isReset:()=>n}}const yw=M.createContext(pw()),vw=()=>M.useContext(yw),xw=(n,l,a)=>{const o=(a==null?void 0:a.state.status)==="error"&&typeof n.throwOnError=="function"?x1(n.throwOnError,[a.state.error,a]):n.throwOnError;(n.suspense||o)&&(l.isReset()||(n.retryOnMount=!1))},Sw=n=>{M.useEffect(()=>{n.clearReset()},[n])},bw=({result:n,errorResetBoundary:l,throwOnError:a,query:o,suspense:c})=>n.isError&&!l.isReset()&&!n.isFetching&&o&&(c&&n.data===void 0||x1(a,[n.error,o])),jw=n=>{if(n.suspense){const a=c=>c==="static"?c:Math.max(c??1e3,1e3),o=n.staleTime;n.staleTime=typeof o=="function"?(...c)=>a(o(...c)):a(o),typeof n.gcTime=="number"&&(n.gcTime=Math.max(n.gcTime,1e3))}},ww=(n,l)=>(n==null?void 0:n.suspense)&&l.isPending,Nw=(n,l,a)=>l.fetchOptimistic(n).catch(()=>{a.clearReset()});function E1(n,l,a){const o=gw(),c=vw(),d=m1(),h=d.defaultQueryOptions(n),m=d.getQueryCache().get(h.queryHash),g=n.subscribed!==!1;h._optimisticResults=o?"isRestoring":g?"optimistic":void 0,jw(h),xw(h,c,m),Sw(c);const[x]=M.useState(()=>new l(d,h)),v=x.getOptimisticResult(h),y=!o&&g;if(M.useSyncExternalStore(M.useCallback(S=>{const j=y?x.subscribe(Bt.batchCalls(S)):Sn;return x.updateResult(),j},[x,y]),()=>x.getCurrentResult(),()=>x.getCurrentResult()),M.useEffect(()=>{x.setOptions(h)},[h,x]),ww(h,v))throw Nw(h,x,c);if(bw({result:v,errorResetBoundary:c,throwOnError:h.throwOnError,query:m,suspense:h.suspense}))throw v.error;return h.notifyOnChangeProps?v:x.trackResult(v)}function fn(n,l){return E1(n,C1)}function Cw(n,l){return E1(n,cw)}var cg=d1();/**
43
+ `+gn+e+oa}var $s=!1;function ms(e,t){if(!e||$s)return"";$s=!0;var s=Error.prepareStackTrace;Error.prepareStackTrace=void 0;try{var o={DetermineComponentFrameRoot:function(){try{if(t){var ne=function(){throw Error()};if(Object.defineProperty(ne.prototype,"props",{set:function(){throw Error()}}),typeof Reflect=="object"&&Reflect.construct){try{Reflect.construct(ne,[])}catch(fe){var F=fe}Reflect.construct(e,[],ne)}else{try{ne.call()}catch(fe){F=fe}ne=!1;try{var Y=Object.getOwnPropertyDescriptor(e.prototype,"props");Object.defineProperty(e.prototype,"props",{configurable:!0,set:function(){throw Error()}}),ne=!0,new e}finally{ne&&(Y!==void 0?Object.defineProperty(e.prototype,"props",Y):delete e.prototype.props)}}}else{try{throw Error()}catch(fe){F=fe}(ne=e())&&typeof ne.catch=="function"&&ne.catch(function(){})}}catch(fe){if(fe&&F&&typeof fe.stack=="string")return[fe.stack,F.stack]}return[null,null]}};o.DetermineComponentFrameRoot.displayName="DetermineComponentFrameRoot";var u=Object.getOwnPropertyDescriptor(o.DetermineComponentFrameRoot,"name");u&&u.configurable&&Object.defineProperty(o.DetermineComponentFrameRoot,"name",{value:"DetermineComponentFrameRoot"});var h=o.DetermineComponentFrameRoot(),y=h[0],w=h[1];if(y&&w){var L=y.split(`
44
+ `),I=w.split(`
45
+ `);for(u=o=0;o<L.length&&!L[o].includes("DetermineComponentFrameRoot");)o++;for(;u<I.length&&!I[u].includes("DetermineComponentFrameRoot");)u++;if(o===L.length||u===I.length)for(o=L.length-1,u=I.length-1;1<=o&&0<=u&&L[o]!==I[u];)u--;for(;1<=o&&0<=u;o--,u--)if(L[o]!==I[u]){if(o!==1||u!==1)do if(o--,u--,0>u||L[o]!==I[u]){var K=`
46
+ `+L[o].replace(" at new "," at ");return e.displayName&&K.includes("<anonymous>")&&(K=K.replace("<anonymous>",e.displayName)),K}while(1<=o&&0<=u);break}}}finally{$s=!1,Error.prepareStackTrace=s}return(s=e?e.displayName||e.name:"")?Ot(s):""}function W(e,t){switch(e.tag){case 26:case 27:case 5:return Ot(e.type);case 16:return Ot("Lazy");case 13:return e.child!==t&&t!==null?Ot("Suspense Fallback"):Ot("Suspense");case 19:return Ot("SuspenseList");case 0:case 15:return ms(e.type,!1);case 11:return ms(e.type.render,!1);case 1:return ms(e.type,!0);case 31:return Ot("Activity");case 30:return Ot("ViewTransition");default:return""}}function he(e){try{var t="",s=null;do t+=W(e,s),s=e,e=e.return;while(e);return t}catch(o){return`
47
+ Error generating stack: `+o.message+`
48
+ `+o.stack}}var we=Object.prototype.hasOwnProperty,Ge=n.unstable_scheduleCallback,Ke=n.unstable_cancelCallback,ft=n.unstable_shouldYield,zt=n.unstable_requestPaint,tt=n.unstable_now,Dt=n.unstable_getCurrentPriorityLevel,Cn=n.unstable_ImmediatePriority,sl=n.unstable_UserBlockingPriority,Mn=n.unstable_NormalPriority,fd=n.unstable_LowPriority,ra=n.unstable_IdlePriority,nc=n.log,bo=n.unstable_setDisableYieldValue,En=null,Ft=null;function ts(e){if(typeof nc=="function"&&bo(e),Ft&&typeof Ft.setStrictMode=="function")try{Ft.setStrictMode(En,e)}catch{}}var ln=Math.clz32?Math.clz32:ac,sc=Math.log,Yl=Math.LN2;function ac(e){return e>>>=0,e===0?32:31-(sc(e)/Yl|0)|0}var Xl=256,ca=262144,bt=4194304;function gs(e){var t=e&42;if(t!==0)return t;switch(e&-e){case 1:return 1;case 2:return 2;case 4:return 4;case 8:return 8;case 16:return 16;case 32:return 32;case 64:return 64;case 128:return 128;case 256:case 512:case 1024:case 2048:case 4096:case 8192:case 16384:case 32768:case 65536:case 131072:return 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t.flags&256?(Ma(t),t.flags&=-257,Xc(e,t,w)):t.memoizedState!==null?(Ea(),t.child=e.child,t.flags|=128,null):(Ea(),h=u.fallback,y=t.mode,u=Yc({mode:"visible",children:u.children},y),h=cl(h,y,w,null),h.flags|=2,u.return=t,h.return=t,u.sibling=h,t.child=u,vl(t,e.child,null,w),u=t.child,u.memoizedState=Mh(w),u.childLanes=Eh(e,o,w),t.memoizedState=Ch,tr(null,u));if(Ma(t),Ef(h)){if(o=h.nextSibling&&h.nextSibling.dataset,o)var L=o.dgst;return o=L,o!==""&&(u=Error(i(419)),u.stack="",u.digest=o,Go({value:u,source:null,stack:null})),Xc(e,t,w)}if(Ct||hl(e,t,w,!1),o=(w&e.childLanes)!==0,Ct||o){if(Ca.current!==null)return Xc(e,t,w);if(o=st,o!==null&&(u=Co(o,w),u!==0&&u!==y.retryLane))throw y.retryLane=u,rl(e,u),bn(o,e,u),wh;return Mf(h)||fu(),Xc(e,t,w)}return Mf(h)?(t.flags|=192,t.child=e.child,null):(e=y.treeContext,at=Kn(h.nextSibling),kt=t,ze=!0,va=null,Yn=!1,e!==null&&D0(t,e),t=Rh(t,u.children),t.flags|=134221824,t)}function Wp(e,t,s){e.lanes|=t;var o=e.alternate;o!==null&&(o.lanes|=t),Ec(e.return,t,s)}function e1(e){for(var t=null;e!==null;){var s=e.alternate;s!==null&&Lc(s)===null&&(t=e),e=e.sibling}return t}function Kc(e,t,s,o,u,h){var y=e.memoizedState;y===null?e.memoizedState={isBackwards:t,rendering:null,renderingStartTime:0,last:o,tail:s,tailMode:u,treeForkCount:h}:(y.isBackwards=t,y.rendering=null,y.renderingStartTime=0,y.last=o,y.tail=s,y.tailMode=u,y.treeForkCount=h)}function Th(e){var t=e.child;for(e.child=null;t!==null;){var s=t.sibling;t.sibling=e.child,e.child=t,t=s}}function _h(e,t,s){var o=t.pendingProps,u=o.revealOrder,h=o.tail;o=o.children;var y=It.current;if(t.flags&128)return Zo(t,y),null;var w=(y&2)!==0;if(w?(y=y&1|2,t.flags|=128):y&=1,Zo(t,y),u==="backwards"&&e!==null?(Th(e),Tt(e,t,o,s),Th(e)):Tt(e,t,o,s),o=ze?Vo:0,!w&&e!==null&&(e.flags&128)!==0)e:for(e=t.child;e!==null;){if(e.tag===13)e.memoizedState!==null&&Wp(e,s,t);else if(e.tag===19)Wp(e,s,t);else 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null;if(e!==null&&t.child!==e.child)throw Error(i(153));if(t.child!==null){for(e=t.child,s=Gs(e,e.pendingProps),t.child=s,s.return=t;e.sibling!==null;)e=e.sibling,s=s.sibling=Gs(e,e.pendingProps),s.return=t;s.sibling=null}return t.child}function Ah(e,t){return(e.lanes&t)!==0?!0:(e=e.dependencies,!!(e!==null&&Rc(e)))}function $S(e,t,s){switch(t.tag){case 3:Ls(t,t.stateNode.containerInfo),ba(t,wt,e.memoizedState.cache),ul();break;case 27:case 5:fs(t);break;case 4:Ls(t,t.stateNode.containerInfo);break;case 10:ba(t,t.type,t.memoizedProps.value);break;case 31:if(t.memoizedState!==null)return t.flags|=128,nh(t),null;break;case 13:var o=t.memoizedState;if(o!==null){if(o.dehydrated!==null)return Ma(t),t.flags|=128,null;o=hl(e,t,s,!1);var u=t.child.childLanes;return o||(s&u)!==0?Jp(e,t,s):(Ma(t),e=Xs(e,t,s),e!==null?e.sibling:null)}Ma(t);break;case 19:if(t.flags&128)return _h(e,t,s);if(u=(e.flags&128)!==0,o=(s&t.childLanes)!==0,o||(hl(e,t,s,!1),o=(s&t.childLanes)!==0),u){if(o)return _h(e,t,s);t.flags|=128}if(u=t.memoizedState,u!==null&&(u.rendering=null,u.tail=null,u.lastEffect=null),Zo(t,It.current),o)break;return null;case 22:return t.lanes=0,Pp(e,t,s,t.pendingProps);case 24:ba(t,wt,e.memoizedState.cache)}return Xs(e,t,s)}function n1(e,t,s){if(e!==null)if(e.memoizedProps!==t.pendingProps)Ct=!0;else{if(!Ah(e,s)&&(t.flags&128)===0)return Ct=!1,$S(e,t,s);Ct=(e.flags&131072)!==0}else Ct=!1,ze&&(t.flags&1048576)!==0&&z0(t,Vo,t.index);switch(t.lanes=0,t.tag){case 16:e:{var o=t.pendingProps;if(e=pl(t.elementType),t.type=e,typeof e=="function")Hd(e)?(o=bl(e,o),t.tag=1,t=Kp(null,t,e,o,s)):(t.tag=0,t=Nh(null,t,e,o,s));else{if(e!=null){var u=e.$$typeof;if(u===$){t.tag=11,t=Gp(null,t,e,o,s);break e}else if(u===le){t.tag=14,t=qp(null,t,e,o,s);break e}else if(u===re){t.tag=10,t.type=e,t=t1(null,t,s);break e}}throw t=be(e)||e,Error(i(306,t,""))}}return t;case 0:return Nh(e,t,t.type,t.pendingProps,s);case 1:return o=t.type,u=bl(o,t.pendingProps),Kp(e,t,o,u,s);case 3:e:{if(Ls(t,t.stateNode.containerInfo),e===null)throw Error(i(387));o=t.pendingProps;var h=t.memoizedState;u=h.element,Zd(e,t),Ko(t,o,null,s);var y=t.memoizedState;if(o=y.cache,ba(t,wt,o),o!==h.cache&&Id(t,[wt],s,!0),Xo(),o=y.element,h.isDehydrated)if(h={element:o,isDehydrated:!1,cache:y.cache},t.updateQueue.baseState=h,t.memoizedState=h,t.flags&256){t=Zp(e,t,o,s);break e}else if(o!==u){u=In(Error(i(424)),t),Go(u),t=Zp(e,t,o,s);break e}else{switch(e=t.stateNode.containerInfo,e.nodeType){case 9:e=e.body;break;default:e=e.nodeName==="HTML"?e.ownerDocument.body:e}for(at=Kn(e.firstChild),kt=t,ze=!0,va=null,Yn=!0,s=P0(t,null,o,s),t.child=s;s;)s.flags=s.flags&-3|134221824,s=s.sibling}else{if(ul(),o===u){t=Xs(e,t,s);break e}Tt(e,t,o,s)}t=t.child}return t;case 26:return xi(e,t),e===null?(s=Ex(t.type,null,t.pendingProps,null))?t.memoizedState=s:ze||(t.stateNode=ix(t.type,t.pendingProps,Jt.current,t)):t.memoizedState=Ex(t.type,e.memoizedProps,t.pendingProps,e.memoizedState),null;case 27:return fs(t),e===null&&ze&&(o=t.stateNode=wx(t.type,t.pendingProps,Jt.current),kt=t,Yn=!0,u=at,ka(t.type)?(Rf=u,at=Kn(o.firstChild)):at=u),Tt(e,t,t.pendingProps.children,s),xi(e,t),e===null&&(t.flags|=4194304),t.child;case 5:return e===null&&ze&&((u=o=at)&&(o=Aj(o,t.type,t.pendingProps,Yn),o!==null?(t.stateNode=o,kt=t,at=Kn(o.firstChild),Yn=!1,u=!0):u=!1),u||ya(t)),fs(t),u=t.type,h=t.pendingProps,y=e!==null?e.memoizedProps:null,o=h.children,yf(u,h)?o=null:y!==null&&yf(u,y)&&(t.flags|=32),t.memoizedState!==null&&(u=lh(e,t,MS,null,null,s),ki._currentValue=u),xi(e,t),Tt(e,t,o,s),t.child;case 6:return e===null&&ze&&((e=s=at)&&(s=Oj(s,t.pendingProps,Yn),s!==null?(t.stateNode=s,kt=t,at=null,e=!0):e=!1),e||ya(t)),null;case 13:return Jp(e,t,s);case 4:return Ls(t,t.stateNode.containerInfo),o=t.pendingProps,e===null?t.child=vl(t,null,o,s):Tt(e,t,o,s),t.child;case 11:return Gp(e,t,t.type,t.pendingProps,s);case 7:return o=t.pendingProps,xi(e,t),Tt(e,t,o,s),t.child;case 8:return Tt(e,t,t.pendingProps.children,s),t.child;case 12:return Tt(e,t,t.pendingProps.children,s),t.child;case 10:return t1(e,t,s);case 9:return u=t.type._context,o=t.pendingProps.children,fl(t),u=Gt(u),o=o(u),t.flags|=1,Tt(e,t,o,s),t.child;case 14:return qp(e,t,t.type,t.pendingProps,s);case 15:return Ip(e,t,t.type,t.pendingProps,s);case 19:return _h(e,t,s);case 31:return kS(e,t,s);case 22:return Pp(e,t,s,t.pendingProps);case 24:return fl(t),o=Gt(wt),e===null?(u=Yd(),u===null&&(u=st,h=Pd(),u.pooledCache=h,h.refCount++,h!==null&&(u.pooledCacheLanes|=s),u=h),t.memoizedState={parent:o,cache:u},Kd(t),ba(t,wt,u)):((e.lanes&s)!==0&&(Zd(e,t),Ko(t,null,null,s),Xo()),u=e.memoizedState,h=t.memoizedState,u.parent!==o?(u={parent:o,cache:o},t.memoizedState=u,t.lanes===0&&(t.memoizedState=t.updateQueue.baseState=u),ba(t,wt,o)):(o=h.cache,ba(t,wt,o),o!==u.cache&&Id(t,[wt],s,!0))),Tt(e,t,t.pendingProps.children,s),t.child;case 30:return t.stateNode===null&&(t.stateNode={autoName:null,paired:null,clones:null,ref:null}),o=t.pendingProps,o.name!=null&&o.name!=="auto"?t.flags|=e===null?18882560:18874368:ze&&Cc(t),e!==null&&e.memoizedProps.name!==o.name?t.flags|=4194816:xi(e,t),Tt(e,t,o.children,s),t.child;case 29:throw t.pendingProps}throw Error(i(156,t.tag))}function Ks(e){e.flags|=4}function Oh(e,t,s,o,u){var h;if((h=(e.mode&32)!==0)&&(h=s===null?Ax(t,o):Ax(t,o)&&(o.src!==s.src||o.srcSet!==s.srcSet)),h){if(e.flags|=16777216,(u&335544128)===u)if(e.stateNode.complete)e.flags|=8192;else if($1())e.flags|=8192;else throw xl=Oc,Xd}else e.flags&=-16777217}function s1(e,t){if(t.type!=="stylesheet"||(t.state.loading&4)!==0)e.flags&=-16777217;else if(e.flags|=16777216,!Ox(t))if($1())e.flags|=8192;else throw xl=Oc,Xd}function Zc(e,t){t!==null&&(e.flags|=4),e.flags&16384&&(t=e.tag!==22?jo():536870912,e.lanes|=t,ji|=t)}function nr(e,t){if(!ze)switch(e.tailMode){case"visible":break;case"collapsed":for(var s=e.tail,o=null;s!==null;)s.alternate!==null&&(o=s),s=s.sibling;o===null?t||e.tail===null?e.tail=null:e.tail.sibling=null:o.sibling=null;break;default:for(t=e.tail,s=null;t!==null;)t.alternate!==null&&(s=t),t=t.sibling;s===null?e.tail=null:s.sibling=null}}function lt(e){var t=e.alternate!==null&&e.alternate.child===e.child,s=0,o=0;if(t)for(var u=e.child;u!==null;)s|=u.lanes|u.childLanes,o|=u.subtreeFlags&1206910976,o|=u.flags&1206910976,u.return=e,u=u.sibling;else for(u=e.child;u!==null;)s|=u.lanes|u.childLanes,o|=u.subtreeFlags,o|=u.flags,u.return=e,u=u.sibling;return e.subtreeFlags|=o,e.childLanes=s,t}function HS(e,t,s){var o=t.pendingProps;switch(Fd(t),t.tag){case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return lt(t),null;case 1:return lt(t),null;case 3:return s=t.stateNode,o=null,e!==null&&(o=e.memoizedState.cache),t.memoizedState.cache!==o&&(t.flags|=2048),Ps(wt),xt(),s.pendingContext&&(s.context=s.pendingContext,s.pendingContext=null),(e===null||e.child===null)&&(ui(t)?Ks(t):e===null||e.memoizedState.isDehydrated&&(t.flags&256)===0||(t.flags|=1024,Gd())),lt(t),null;case 26:var u=t.type,h=t.memoizedState;return e===null?(Ks(t),h!==null?(lt(t),s1(t,h)):(lt(t),Oh(t,u,null,o,s))):h?h!==e.memoizedState?(Ks(t),lt(t),s1(t,h)):(lt(t),t.flags&=-16777217):(e=e.memoizedProps,e!==o&&Ks(t),lt(t),Oh(t,u,e,o,s)),null;case 27:if(an(t),s=Jt.current,u=t.type,e!==null&&t.stateNode!=null)e.memoizedProps!==o&&Ks(t);else{if(!o){if(t.stateNode===null)throw Error(i(166));return lt(t),t.subtreeFlags&=-33554433,null}e=Bt.current,ui(t)?k0(t):(e=wx(u,o,s),t.stateNode=e,Ks(t))}return lt(t),t.subtreeFlags&=-33554433,null;case 5:if(an(t),u=t.type,e!==null&&t.stateNode!=null)e.memoizedProps!==o&&Ks(t);else{if(!o){if(t.stateNode===null)throw Error(i(166));return lt(t),t.subtreeFlags&=-33554433,null}if(h=Bt.current,ui(t))k0(t);else{var y=fr(Jt.current);switch(h){case 1:h=y.createElementNS("http://www.w3.org/2000/svg",u);break;case 2:h=y.createElementNS("http://www.w3.org/1998/Math/MathML",u);break;default:switch(u){case"svg":h=y.createElementNS("http://www.w3.org/2000/svg",u);break;case"math":h=y.createElementNS("http://www.w3.org/1998/Math/MathML",u);break;case"script":h=y.createElement("div"),h.innerHTML="<script><\/script>",h=h.removeChild(h.firstChild);break;case"select":h=typeof o.is=="string"?y.createElement("select",{is:o.is}):y.createElement("select"),o.multiple?h.multiple=!0:o.size&&(h.size=o.size);break;default:h=typeof o.is=="string"?y.createElement(u,{is:o.is}):y.createElement(u)}}h[St]=t,h[Vt]=o;e:for(y=t.child;y!==null;){if(y.tag===5||y.tag===6)h.appendChild(y.stateNode);else if(y.tag!==4&&y.tag!==27&&y.child!==null){y.child.return=y,y=y.child;continue}if(y===t)break e;for(;y.sibling===null;){if(y.return===null||y.return===t)break e;y=y.return}y.sibling.return=y.return,y=y.sibling}t.stateNode=h;e:switch(Qt(h,u,o),u){case"button":case"input":case"select":case"textarea":o=!!o.autoFocus;break e;case"img":o=!0;break e;default:o=!1}o&&Ks(t)}}return lt(t),t.subtreeFlags&=-33554433,Oh(t,t.type,e===null?null:e.memoizedProps,t.pendingProps,s),null;case 6:if(e&&t.stateNode!=null)e.memoizedProps!==o&&Ks(t);else{if(typeof o!="string"&&t.stateNode===null)throw Error(i(166));if(e=Jt.current,ui(t)){if(e=t.stateNode,s=t.memoizedProps,o=null,u=kt,u!==null)switch(u.tag){case 27:case 5:o=u.memoizedProps}e[St]=t,e=!!(e.nodeValue===s||o!==null&&o.suppressHydrationWarning===!0||nx(e.nodeValue,s)),e||ya(t,!0)}else e=fr(e).createTextNode(o),e[St]=t,t.stateNode=e}return lt(t),null;case 31:if(s=t.memoizedState,e===null||e.memoizedState!==null){if(o=ui(t),s!==null){if(e===null){if(!o)throw Error(i(318));if(e=t.memoizedState,e=e!==null?e.dehydrated:null,!e)throw Error(i(557));e[St]=t}else 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50
50
  * @remix-run/router v1.23.4
51
51
  *
52
52
  * Copyright (c) Remix Software Inc.
@@ -55,7 +55,7 @@ Error generating stack: `+i.message+`
55
55
  * LICENSE.md file in the root directory of this source tree.
56
56
  *
57
57
  * @license MIT
58
- */function Tr(){return Tr=Object.assign?Object.assign.bind():function(n){for(var l=1;l<arguments.length;l++){var a=arguments[l];for(var o in a)({}).hasOwnProperty.call(a,o)&&(n[o]=a[o])}return n},Tr.apply(null,arguments)}var Ul;(function(n){n.Pop="POP",n.Push="PUSH",n.Replace="REPLACE"})(Ul||(Ul={}));const ex="popstate";function Mw(n){n===void 0&&(n={});function l(o,c){let{pathname:d,search:h,hash:m}=o.location;return Am("",{pathname:d,search:h,hash:m},c.state&&c.state.usr||null,c.state&&c.state.key||"default")}function a(o,c){return typeof c=="string"?c:_1(c)}return Tw(l,a,null,n)}function Nt(n,l){if(n===!1||n===null||typeof n>"u")throw new Error(l)}function T1(n,l){if(!n){typeof console<"u"&&console.warn(l);try{throw new Error(l)}catch{}}}function Ew(){return Math.random().toString(36).substr(2,8)}function tx(n,l){return{usr:n.state,key:n.key,idx:l}}function Am(n,l,a,o){return a===void 0&&(a=null),Tr({pathname:typeof n=="string"?n:n.pathname,search:"",hash:""},typeof l=="string"?co(l):l,{state:a,key:l&&l.key||o||Ew()})}function _1(n){let{pathname:l="/",search:a="",hash:o=""}=n;return a&&a!=="?"&&(l+=a.charAt(0)==="?"?a:"?"+a),o&&o!=="#"&&(l+=o.charAt(0)==="#"?o:"#"+o),l}function co(n){let l={};if(n){let a=n.indexOf("#");a>=0&&(l.hash=n.substr(a),n=n.substr(0,a));let o=n.indexOf("?");o>=0&&(l.search=n.substr(o),n=n.substr(0,o)),n&&(l.pathname=n)}return l}function Tw(n,l,a,o){o===void 0&&(o={});let{window:c=document.defaultView,v5Compat:d=!1}=o,h=c.history,m=Ul.Pop,g=null,x=v();x==null&&(x=0,h.replaceState(Tr({},h.state,{idx:x}),""));function v(){return(h.state||{idx:null}).idx}function y(){m=Ul.Pop;let T=v(),O=T==null?null:T-x;x=T,g&&g({action:m,location:N.location,delta:O})}function S(T,O){m=Ul.Push;let _=Am(N.location,T,O);x=v()+1;let D=tx(_,x),C=N.createHref(_);try{h.pushState(D,"",C)}catch(E){if(E instanceof DOMException&&E.name==="DataCloneError")throw E;c.location.assign(C)}d&&g&&g({action:m,location:N.location,delta:1})}function j(T,O){m=Ul.Replace;let _=Am(N.location,T,O);x=v();let D=tx(_,x),C=N.createHref(_);h.replaceState(D,"",C),d&&g&&g({action:m,location:N.location,delta:0})}function b(T){let O=c.location.origin!=="null"?c.location.origin:c.location.href,_=typeof T=="string"?T:_1(T);return _=_.replace(/ $/,"%20"),Nt(O,"No window.location.(origin|href) available to create URL for href: "+_),new URL(_,O)}let N={get action(){return m},get location(){return n(c,h)},listen(T){if(g)throw new Error("A history only accepts one active listener");return c.addEventListener(ex,y),g=T,()=>{c.removeEventListener(ex,y),g=null}},createHref(T){return l(c,T)},createURL:b,encodeLocation(T){let O=b(T);return{pathname:O.pathname,search:O.search,hash:O.hash}},push:S,replace:j,go(T){return h.go(T)}};return N}var nx;(function(n){n.data="data",n.deferred="deferred",n.redirect="redirect",n.error="error"})(nx||(nx={}));function _w(n,l,a){return a===void 0&&(a="/"),Rw(n,l,a)}function Rw(n,l,a,o){let c=typeof l=="string"?co(l):l,d=D1(c.pathname||"/",a);if(d==null)return null;let h=R1(n);Aw(h);let m=null,g=z1(d);for(let x=0;m==null&&x<h.length;++x)m=Fw(h[x],g);return m}function R1(n,l,a,o){l===void 0&&(l=[]),a===void 0&&(a=[]),o===void 0&&(o="");let c=(d,h,m)=>{let g={relativePath:m===void 0?d.path||"":m,caseSensitive:d.caseSensitive===!0,childrenIndex:h,route:d};g.relativePath.startsWith("/")&&(Nt(g.relativePath.startsWith(o),'Absolute route path "'+g.relativePath+'" nested under path '+('"'+o+'" is not valid. 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59
59
  * React Router v6.30.6
60
60
  *
61
61
  * Copyright (c) Remix Software Inc.
@@ -64,7 +64,7 @@ Error generating stack: `+i.message+`
64
64
  * LICENSE.md file in the root directory of this source tree.
65
65
  *
66
66
  * @license MIT
67
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- */const I1=He("ChartScatter",[["circle",{cx:"7.5",cy:"7.5",r:".5",fill:"currentColor",key:"kqv944"}],["circle",{cx:"18.5",cy:"5.5",r:".5",fill:"currentColor",key:"lysivs"}],["circle",{cx:"11.5",cy:"11.5",r:".5",fill:"currentColor",key:"byv1b8"}],["circle",{cx:"7.5",cy:"16.5",r:".5",fill:"currentColor",key:"nkw3mc"}],["circle",{cx:"17.5",cy:"14.5",r:".5",fill:"currentColor",key:"1gjh6j"}],["path",{d:"M3 3v16a2 2 0 0 0 2 2h16",key:"c24i48"}]]);/**
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+ */const my=Oe("ChartScatter",[["circle",{cx:"7.5",cy:"7.5",r:".5",fill:"currentColor",key:"kqv944"}],["circle",{cx:"18.5",cy:"5.5",r:".5",fill:"currentColor",key:"lysivs"}],["circle",{cx:"11.5",cy:"11.5",r:".5",fill:"currentColor",key:"byv1b8"}],["circle",{cx:"7.5",cy:"16.5",r:".5",fill:"currentColor",key:"nkw3mc"}],["circle",{cx:"17.5",cy:"14.5",r:".5",fill:"currentColor",key:"1gjh6j"}],["path",{d:"M3 3v16a2 2 0 0 0 2 2h16",key:"c24i48"}]]);/**
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const Q1=He("Check",[["path",{d:"M20 6 9 17l-5-5",key:"1gmf2c"}]]);/**
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+ */const gy=Oe("Check",[["path",{d:"M20 6 9 17l-5-5",key:"1gmf2c"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const Y1=He("ChevronDown",[["path",{d:"m6 9 6 6 6-6",key:"qrunsl"}]]);/**
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+ */const py=Oe("ChevronDown",[["path",{d:"m6 9 6 6 6-6",key:"qrunsl"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const dg=He("ChevronRight",[["path",{d:"m9 18 6-6-6-6",key:"mthhwq"}]]);/**
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+ */const ad=Oe("ChevronRight",[["path",{d:"m9 18 6-6-6-6",key:"mthhwq"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const RN=He("CircleAlert",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"12",x2:"12",y1:"8",y2:"12",key:"1pkeuh"}],["line",{x1:"12",x2:"12.01",y1:"16",y2:"16",key:"4dfq90"}]]);/**
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+ */const oC=Oe("CircleAlert",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"12",x2:"12",y1:"8",y2:"12",key:"1pkeuh"}],["line",{x1:"12",x2:"12.01",y1:"16",y2:"16",key:"4dfq90"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const AN=He("CircleCheck",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"m9 12 2 2 4-4",key:"dzmm74"}]]);/**
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+ */const xy=Oe("CircleCheck",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"m9 12 2 2 4-4",key:"dzmm74"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const ON=He("CircleDashed",[["path",{d:"M10.1 2.182a10 10 0 0 1 3.8 0",key:"5ilxe3"}],["path",{d:"M13.9 21.818a10 10 0 0 1-3.8 0",key:"11zvb9"}],["path",{d:"M17.609 3.721a10 10 0 0 1 2.69 2.7",key:"1iw5b2"}],["path",{d:"M2.182 13.9a10 10 0 0 1 0-3.8",key:"c0bmvh"}],["path",{d:"M20.279 17.609a10 10 0 0 1-2.7 2.69",key:"1ruxm7"}],["path",{d:"M21.818 10.1a10 10 0 0 1 0 3.8",key:"qkgqxc"}],["path",{d:"M3.721 6.391a10 10 0 0 1 2.7-2.69",key:"1mcia2"}],["path",{d:"M6.391 20.279a10 10 0 0 1-2.69-2.7",key:"1fvljs"}]]);/**
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+ */const rC=Oe("CircleDashed",[["path",{d:"M10.1 2.182a10 10 0 0 1 3.8 0",key:"5ilxe3"}],["path",{d:"M13.9 21.818a10 10 0 0 1-3.8 0",key:"11zvb9"}],["path",{d:"M17.609 3.721a10 10 0 0 1 2.69 2.7",key:"1iw5b2"}],["path",{d:"M2.182 13.9a10 10 0 0 1 0-3.8",key:"c0bmvh"}],["path",{d:"M20.279 17.609a10 10 0 0 1-2.7 2.69",key:"1ruxm7"}],["path",{d:"M21.818 10.1a10 10 0 0 1 0 3.8",key:"qkgqxc"}],["path",{d:"M3.721 6.391a10 10 0 0 1 2.7-2.69",key:"1mcia2"}],["path",{d:"M6.391 20.279a10 10 0 0 1-2.69-2.7",key:"1fvljs"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const P1=He("Copy",[["rect",{width:"14",height:"14",x:"8",y:"8",rx:"2",ry:"2",key:"17jyea"}],["path",{d:"M4 16c-1.1 0-2-.9-2-2V4c0-1.1.9-2 2-2h10c1.1 0 2 .9 2 2",key:"zix9uf"}]]);/**
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+ */const vy=Oe("Copy",[["rect",{width:"14",height:"14",x:"8",y:"8",rx:"2",ry:"2",key:"17jyea"}],["path",{d:"M4 16c-1.1 0-2-.9-2-2V4c0-1.1.9-2 2-2h10c1.1 0 2 .9 2 2",key:"zix9uf"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const $m=He("Crosshair",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"22",x2:"18",y1:"12",y2:"12",key:"l9bcsi"}],["line",{x1:"6",x2:"2",y1:"12",y2:"12",key:"13hhkx"}],["line",{x1:"12",x2:"12",y1:"6",y2:"2",key:"10w3f3"}],["line",{x1:"12",x2:"12",y1:"22",y2:"18",key:"15g9kq"}]]);/**
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+ */const tg=Oe("Crosshair",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["line",{x1:"22",x2:"18",y1:"12",y2:"12",key:"l9bcsi"}],["line",{x1:"6",x2:"2",y1:"12",y2:"12",key:"13hhkx"}],["line",{x1:"12",x2:"12",y1:"6",y2:"2",key:"10w3f3"}],["line",{x1:"12",x2:"12",y1:"22",y2:"18",key:"15g9kq"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const Vu=He("Dna",[["path",{d:"m10 16 1.5 1.5",key:"11lckj"}],["path",{d:"m14 8-1.5-1.5",key:"1ohn8i"}],["path",{d:"M15 2c-1.798 1.998-2.518 3.995-2.807 5.993",key:"80uv8i"}],["path",{d:"m16.5 10.5 1 1",key:"696xn5"}],["path",{d:"m17 6-2.891-2.891",key:"xu6p2f"}],["path",{d:"M2 15c6.667-6 13.333 0 20-6",key:"1pyr53"}],["path",{d:"m20 9 .891.891",key:"3xwk7g"}],["path",{d:"M3.109 14.109 4 15",key:"q76aoh"}],["path",{d:"m6.5 12.5 1 1",key:"cs35ky"}],["path",{d:"m7 18 2.891 2.891",key:"1sisit"}],["path",{d:"M9 22c1.798-1.998 2.518-3.995 2.807-5.993",key:"q3hbxp"}]]);/**
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+ */const ld=Oe("Dna",[["path",{d:"m10 16 1.5 1.5",key:"11lckj"}],["path",{d:"m14 8-1.5-1.5",key:"1ohn8i"}],["path",{d:"M15 2c-1.798 1.998-2.518 3.995-2.807 5.993",key:"80uv8i"}],["path",{d:"m16.5 10.5 1 1",key:"696xn5"}],["path",{d:"m17 6-2.891-2.891",key:"xu6p2f"}],["path",{d:"M2 15c6.667-6 13.333 0 20-6",key:"1pyr53"}],["path",{d:"m20 9 .891.891",key:"3xwk7g"}],["path",{d:"M3.109 14.109 4 15",key:"q76aoh"}],["path",{d:"m6.5 12.5 1 1",key:"cs35ky"}],["path",{d:"m7 18 2.891 2.891",key:"1sisit"}],["path",{d:"M9 22c1.798-1.998 2.518-3.995 2.807-5.993",key:"q3hbxp"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
181
- */const X1=He("FlaskConical",[["path",{d:"M14 2v6a2 2 0 0 0 .245.96l5.51 10.08A2 2 0 0 1 18 22H6a2 2 0 0 1-1.755-2.96l5.51-10.08A2 2 0 0 0 10 8V2",key:"18mbvz"}],["path",{d:"M6.453 15h11.094",key:"3shlmq"}],["path",{d:"M8.5 2h7",key:"csnxdl"}]]);/**
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+ */const yy=Oe("ExternalLink",[["path",{d:"M15 3h6v6",key:"1q9fwt"}],["path",{d:"M10 14 21 3",key:"gplh6r"}],["path",{d:"M18 13v6a2 2 0 0 1-2 2H5a2 2 0 0 1-2-2V8a2 2 0 0 1 2-2h6",key:"a6xqqp"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
186
- */const zN=He("FolderOpen",[["path",{d:"m6 14 1.5-2.9A2 2 0 0 1 9.24 10H20a2 2 0 0 1 1.94 2.5l-1.54 6a2 2 0 0 1-1.95 1.5H4a2 2 0 0 1-2-2V5a2 2 0 0 1 2-2h3.9a2 2 0 0 1 1.69.9l.81 1.2a2 2 0 0 0 1.67.9H18a2 2 0 0 1 2 2v2",key:"usdka0"}]]);/**
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+ */const by=Oe("FlaskConical",[["path",{d:"M14 2v6a2 2 0 0 0 .245.96l5.51 10.08A2 2 0 0 1 18 22H6a2 2 0 0 1-1.755-2.96l5.51-10.08A2 2 0 0 0 10 8V2",key:"18mbvz"}],["path",{d:"M6.453 15h11.094",key:"3shlmq"}],["path",{d:"M8.5 2h7",key:"csnxdl"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
191
- */const DN=He("Info",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"M12 16v-4",key:"1dtifu"}],["path",{d:"M12 8h.01",key:"e9boi3"}]]);/**
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+ */const cC=Oe("FolderOpen",[["path",{d:"m6 14 1.5-2.9A2 2 0 0 1 9.24 10H20a2 2 0 0 1 1.94 2.5l-1.54 6a2 2 0 0 1-1.95 1.5H4a2 2 0 0 1-2-2V5a2 2 0 0 1 2-2h3.9a2 2 0 0 1 1.69.9l.81 1.2a2 2 0 0 0 1.67.9H18a2 2 0 0 1 2 2v2",key:"usdka0"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
196
- */const LN=He("LayoutGrid",[["rect",{width:"7",height:"7",x:"3",y:"3",rx:"1",key:"1g98yp"}],["rect",{width:"7",height:"7",x:"14",y:"3",rx:"1",key:"6d4xhi"}],["rect",{width:"7",height:"7",x:"14",y:"14",rx:"1",key:"nxv5o0"}],["rect",{width:"7",height:"7",x:"3",y:"14",rx:"1",key:"1bb6yr"}]]);/**
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+ */const uC=Oe("IdCard",[["path",{d:"M16 10h2",key:"8sgtl7"}],["path",{d:"M16 14h2",key:"epxaof"}],["path",{d:"M6.17 15a3 3 0 0 1 5.66 0",key:"n6f512"}],["circle",{cx:"9",cy:"11",r:"2",key:"yxgjnd"}],["rect",{x:"2",y:"5",width:"20",height:"14",rx:"2",key:"qneu4z"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
201
- */const $N=He("Link2",[["path",{d:"M9 17H7A5 5 0 0 1 7 7h2",key:"8i5ue5"}],["path",{d:"M15 7h2a5 5 0 1 1 0 10h-2",key:"1b9ql8"}],["line",{x1:"8",x2:"16",y1:"12",y2:"12",key:"1jonct"}]]);/**
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+ */const dC=Oe("Info",[["circle",{cx:"12",cy:"12",r:"10",key:"1mglay"}],["path",{d:"M12 16v-4",key:"1dtifu"}],["path",{d:"M12 8h.01",key:"e9boi3"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
206
- */const kN=He("Maximize2",[["polyline",{points:"15 3 21 3 21 9",key:"mznyad"}],["polyline",{points:"9 21 3 21 3 15",key:"1avn1i"}],["line",{x1:"21",x2:"14",y1:"3",y2:"10",key:"ota7mn"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
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+ */const hC=Oe("LayoutGrid",[["rect",{width:"7",height:"7",x:"3",y:"3",rx:"1",key:"1g98yp"}],["rect",{width:"7",height:"7",x:"14",y:"3",rx:"1",key:"6d4xhi"}],["rect",{width:"7",height:"7",x:"14",y:"14",rx:"1",key:"nxv5o0"}],["rect",{width:"7",height:"7",x:"3",y:"14",rx:"1",key:"1bb6yr"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
211
- */const HN=He("Microscope",[["path",{d:"M6 18h8",key:"1borvv"}],["path",{d:"M3 22h18",key:"8prr45"}],["path",{d:"M14 22a7 7 0 1 0 0-14h-1",key:"1jwaiy"}],["path",{d:"M9 14h2",key:"197e7h"}],["path",{d:"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z",key:"1bmzmy"}],["path",{d:"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3",key:"1drr47"}]]);/**
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+ */const fC=Oe("Link2",[["path",{d:"M9 17H7A5 5 0 0 1 7 7h2",key:"8i5ue5"}],["path",{d:"M15 7h2a5 5 0 1 1 0 10h-2",key:"1b9ql8"}],["line",{x1:"8",x2:"16",y1:"12",y2:"12",key:"1jonct"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
216
- */const UN=He("Minimize2",[["polyline",{points:"4 14 10 14 10 20",key:"11kfnr"}],["polyline",{points:"20 10 14 10 14 4",key:"rlmsce"}],["line",{x1:"14",x2:"21",y1:"10",y2:"3",key:"o5lafz"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
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+ */const mC=Oe("MapPin",[["path",{d:"M20 10c0 4.993-5.539 10.193-7.399 11.799a1 1 0 0 1-1.202 0C9.539 20.193 4 14.993 4 10a8 8 0 0 1 16 0",key:"1r0f0z"}],["circle",{cx:"12",cy:"10",r:"3",key:"ilqhr7"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
221
- */const FN=He("Orbit",[["circle",{cx:"12",cy:"12",r:"3",key:"1v7zrd"}],["circle",{cx:"19",cy:"5",r:"2",key:"mhkx31"}],["circle",{cx:"5",cy:"19",r:"2",key:"v8kfzx"}],["path",{d:"M10.4 21.9a10 10 0 0 0 9.941-15.416",key:"eohfx2"}],["path",{d:"M13.5 2.1a10 10 0 0 0-9.841 15.416",key:"19pvbm"}]]);/**
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+ */const gC=Oe("Maximize2",[["polyline",{points:"15 3 21 3 21 9",key:"mznyad"}],["polyline",{points:"9 21 3 21 3 15",key:"1avn1i"}],["line",{x1:"21",x2:"14",y1:"3",y2:"10",key:"ota7mn"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
225
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  * See the LICENSE file in the root directory of this source tree.
226
- */const VN=He("PanelLeftClose",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m16 15-3-3 3-3",key:"14y99z"}]]);/**
226
+ */const pC=Oe("Microscope",[["path",{d:"M6 18h8",key:"1borvv"}],["path",{d:"M3 22h18",key:"8prr45"}],["path",{d:"M14 22a7 7 0 1 0 0-14h-1",key:"1jwaiy"}],["path",{d:"M9 14h2",key:"197e7h"}],["path",{d:"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z",key:"1bmzmy"}],["path",{d:"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3",key:"1drr47"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
231
- */const BN=He("PanelLeftOpen",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m14 9 3 3-3 3",key:"8010ee"}]]);/**
231
+ */const xC=Oe("Minimize2",[["polyline",{points:"4 14 10 14 10 20",key:"11kfnr"}],["polyline",{points:"20 10 14 10 14 4",key:"rlmsce"}],["line",{x1:"14",x2:"21",y1:"10",y2:"3",key:"o5lafz"}],["line",{x1:"3",x2:"10",y1:"21",y2:"14",key:"1atl0r"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
236
- */const _u=He("Search",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["path",{d:"m21 21-4.3-4.3",key:"1qie3q"}]]);/**
236
+ */const vC=Oe("Orbit",[["circle",{cx:"12",cy:"12",r:"3",key:"1v7zrd"}],["circle",{cx:"19",cy:"5",r:"2",key:"mhkx31"}],["circle",{cx:"5",cy:"19",r:"2",key:"v8kfzx"}],["path",{d:"M10.4 21.9a10 10 0 0 0 9.941-15.416",key:"eohfx2"}],["path",{d:"M13.5 2.1a10 10 0 0 0-9.841 15.416",key:"19pvbm"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
241
- */const GN=He("Shield",[["path",{d:"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z",key:"oel41y"}]]);/**
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+ */const yC=Oe("PanelLeftClose",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m16 15-3-3 3-3",key:"14y99z"}]]);/**
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  * @license lucide-react v0.468.0 - ISC
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const qN=He("Shuffle",[["path",{d:"m18 14 4 4-4 4",key:"10pe0f"}],["path",{d:"m18 2 4 4-4 4",key:"pucp1d"}],["path",{d:"M2 18h1.973a4 4 0 0 0 3.3-1.7l5.454-8.6a4 4 0 0 1 3.3-1.7H22",key:"1ailkh"}],["path",{d:"M2 6h1.972a4 4 0 0 1 3.6 2.2",key:"km57vx"}],["path",{d:"M22 18h-6.041a4 4 0 0 1-3.3-1.8l-.359-.45",key:"os18l9"}]]);/**
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+ */const bC=Oe("PanelLeftOpen",[["rect",{width:"18",height:"18",x:"3",y:"3",rx:"2",key:"afitv7"}],["path",{d:"M9 3v18",key:"fh3hqa"}],["path",{d:"m14 9 3 3-3 3",key:"8010ee"}]]);/**
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  *
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  * This source code is licensed under the ISC license.
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- */const K1=He("TriangleAlert",[["path",{d:"m21.73 18-8-14a2 2 0 0 0-3.48 0l-8 14A2 2 0 0 0 4 21h16a2 2 0 0 0 1.73-3",key:"wmoenq"}],["path",{d:"M12 9v4",key:"juzpu7"}],["path",{d:"M12 17h.01",key:"p32p05"}]]);/**
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+ */const SC=Oe("Pill",[["path",{d:"m10.5 20.5 10-10a4.95 4.95 0 1 0-7-7l-10 10a4.95 4.95 0 1 0 7 7Z",key:"wa1lgi"}],["path",{d:"m8.5 8.5 7 7",key:"rvfmvr"}]]);/**
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const IN=He("UserRound",[["circle",{cx:"12",cy:"8",r:"5",key:"1hypcn"}],["path",{d:"M20 21a8 8 0 0 0-16 0",key:"rfgkzh"}]]);/**
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+ */const Iu=Oe("Search",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["path",{d:"m21 21-4.3-4.3",key:"1qie3q"}]]);/**
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const QN=He("Users",[["path",{d:"M16 21v-2a4 4 0 0 0-4-4H6a4 4 0 0 0-4 4v2",key:"1yyitq"}],["circle",{cx:"9",cy:"7",r:"4",key:"nufk8"}],["path",{d:"M22 21v-2a4 4 0 0 0-3-3.87",key:"kshegd"}],["path",{d:"M16 3.13a4 4 0 0 1 0 7.75",key:"1da9ce"}]]);/**
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+ */const jC=Oe("Shield",[["path",{d:"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z",key:"oel41y"}]]);/**
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  *
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  * This source code is licensed under the ISC license.
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  * See the LICENSE file in the root directory of this source tree.
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- */const YN=He("Waves",[["path",{d:"M2 6c.6.5 1.2 1 2.5 1C7 7 7 5 9.5 5c2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"knzxuh"}],["path",{d:"M2 12c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"2jd2cc"}],["path",{d:"M2 18c.6.5 1.2 1 2.5 1 2.5 0 2.5-2 5-2 2.6 0 2.4 2 5 2 2.5 0 2.5-2 5-2 1.3 0 1.9.5 2.5 1",key:"rd2r6e"}]]);/**
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+ */const wC=Oe("Shuffle",[["path",{d:"m18 14 4 4-4 4",key:"10pe0f"}],["path",{d:"m18 2 4 4-4 4",key:"pucp1d"}],["path",{d:"M2 18h1.973a4 4 0 0 0 3.3-1.7l5.454-8.6a4 4 0 0 1 3.3-1.7H22",key:"1ailkh"}],["path",{d:"M2 6h1.972a4 4 0 0 1 3.6 2.2",key:"km57vx"}],["path",{d:"M22 18h-6.041a4 4 0 0 1-3.3-1.8l-.359-.45",key:"os18l9"}]]);/**
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  *
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  * See the LICENSE file in the root directory of this source tree.
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- */const Bu=He("X",[["path",{d:"M18 6 6 18",key:"1bl5f8"}],["path",{d:"m6 6 12 12",key:"d8bk6v"}]]);/**
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+ */const NC=Oe("Stethoscope",[["path",{d:"M11 2v2",key:"1539x4"}],["path",{d:"M5 2v2",key:"1yf1q8"}],["path",{d:"M5 3H4a2 2 0 0 0-2 2v4a6 6 0 0 0 12 0V5a2 2 0 0 0-2-2h-1",key:"rb5t3r"}],["path",{d:"M8 15a6 6 0 0 0 12 0v-3",key:"x18d4x"}],["circle",{cx:"20",cy:"10",r:"2",key:"ts1r5v"}]]);/**
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  *
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  * See the LICENSE file in the root directory of this source tree.
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- */const Z1=He("ZoomOut",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["line",{x1:"21",x2:"16.65",y1:"21",y2:"16.65",key:"13gj7c"}],["line",{x1:"8",x2:"14",y1:"11",y2:"11",key:"durymu"}]]);function PN(n){if(n.value===null)return n.text??"";switch(n.key){case"coverage":return`${Math.round(n.value)}×`;case"tmb":return n.value<.01?n.value.toPrecision(2):n.value.toFixed(2);default:return n.value.toFixed(2)}}function XN(n){return n.status==="failed"?"Failed":n.status==="skipped"?"Not in this mode":"Not run"}const KN=new Intl.DateTimeFormat("en-GB",{day:"numeric",month:"short",year:"numeric"});function J1(n){if(!n)return"";const l=new Date(n);return Number.isNaN(l.getTime())?"":KN.format(l)}function hg(n,l){return n.startsWith(`${l}_`)?n.slice(l.length+1):n}function km(n){return n==null?"–":n.toFixed(2)}const cx={missense_variant:"Missense",stop_gained:"Nonsense",stop_lost:"Stop lost",start_lost:"Start lost",frameshift_variant:"Frameshift",inframe_deletion:"In-frame 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r.jsxs("div",{className:"flex items-start gap-2.5 text-sm",style:{color:"var(--ink-2)"},children:[r.jsx(a,{size:18,"aria-hidden":!0,style:{color:l?"var(--warn-ink)":"var(--chev)",flex:"none"}}),r.jsxs("div",{className:"flex flex-col gap-1",children:[r.jsx("span",{className:"font-semibold",style:{color:"var(--ink)"},children:l?"This panel could not be read":"Nothing to show here"}),n.warnings.map(o=>r.jsx("span",{children:o},o))]})]})}const Vm={summary:{title:"Genome fingerprint and summary",intro:"A one-glance portrait of the selected tumour: its copy-number changes and driver mutations drawn as a ring, a sentence describing them, and the headline measurements of the sample.",sections:[{heading:"The fingerprint ring",paragraphs:["The ring is the whole genome. Chromosome 1 starts at the top and the ring runs clockwise through chromosome 22 to X, each chromosome's arc in proportion to its length (GRCh37).","Copy-number changes are called against the tumour's baseline, its ploidy rounded to whole copies. Very short changes are drawn at a minimum length so they stay visible."],terms:[["Gains (outer track, orange)","Regions with at least one copy more than the baseline."],["Amplifications (outer track, darker and thicker)","Regions with three or more copies above the baseline."],["Losses (inner track, blue)","Regions with at least one copy fewer than the baseline."],["Drivers (black ticks)","Where the tumour's likely driver mutations sit (see the Mutations card for how they are flagged)."]]},{heading:"The sentence",paragraphs:["Written from the same data as the ring: how many amplifications, gains and losses there are and on which chromosomes, and which genes carry driver mutations."]},{heading:"The measurements",paragraphs:["Each tile shows a value, a small picture of where it sits on its scale when it has a natural one, and the analysis it came from. A tile with no value says why: the analysis was not run, it failed, or it does not apply to this kind of report (tumour-only reports have no matched normal)."],terms:[["Purity","The estimated fraction of cells in the sample that are tumour cells, from 0 to 1. The ring fills to the value."],["Ploidy","The tumour's average number of copies across the genome. The scale runs from 1 to 6 copies; the tall tick marks 2, a diploid genome."],["Coverage","The median sequencing depth of the tumour across the genome, in reads (×)."],["TMB per Mb","Tumour mutational burden: somatic SNVs and indels per megabase of genome. The report computes it from the counts of the SNV and indel calls. The scale is logarithmic, 0.01 to 100."],["MSI score","The MSIsensor score: the percentage of microsatellite sites that look unstable in the tumour."],["FGA","Fraction of the genome altered: the share of the genome whose copy number differs from the baseline, from 0 to 1. It is read from the project-wide Battenberg tables."]]},{heading:"Linking back to the analyses",paragraphs:[`Every value names its analysis, with version and Isabl id. Picking an analysis in the side menu's "Analyses on this page" highlights the tiles and cards it feeds.`]}]},copyNumber:{title:"Copy number",intro:"How many copies of each part of the genome the tumour carries, segment by segment, from chromosome 1 to X.",sections:[{heading:"What is drawn",paragraphs:['Each horizontal stroke is one segment: a stretch of the genome with a constant copy number. Its height is the number of copies, from 0 up to 8; anything higher is drawn at the top and the axis reads "8+". A gain or amplification rises as a column from the baseline to its stroke, and a loss falls to it, so the changes read as a landscape. Alternating grey bands mark the chromosomes, named in a strip along the bottom.',`The line across the plot is the baseline: the tumour's ploidy rounded to whole copies (labelled, for example, "2 copies"). Segments are coloured by how they compare with it.`],terms:[["Grey","Neutral: the same number of copies as the baseline."],["Orange","Gain: at least one copy more than the baseline."],["Dark orange","Amplification: three or more copies above the baseline."],["Blue","Loss: at least one copy fewer than the baseline."]]},{heading:"Total or allele-specific",paragraphs:["Total shows all copies together. Allele-specific, when the analysis provides it, splits each segment into its major allele (the more common parental copy, dark) and minor allele (light). Where the two are equal they are drawn slightly apart so both stay visible. A minor allele of 0 means one parent's copy is lost there (loss of heterozygosity)."]},{heading:"Driver genes",paragraphs:["A label along the top names each gene with likely driver mutations, one per gene, joined by a line to a dot on the segment the gene sits on, so its copy number can be read off at once. Hover one for its protein changes and the copies there."]},{heading:"Amplified and lost genes",paragraphs:["The oncogenes the report calls amplified and the tumour suppressors it calls homozygously lost, from the copy number over each gene, in chromosome order. The row of cells shows the copy number (all eight filled means eight copies or more). When the sample has RNA, each gene also shows its expression against each expression cohort: the log2 of this sample's level over the cohort's mean, so +1 is twice the cohort's level. Point at a gene to mark it on the plot; click it to glide to its chromosome."]},{heading:"Fraction of genome altered against the cohort",paragraphs:["The tumour's FGA (the share of the genome whose copy number differs from the baseline) set against every tumour in the project's FGA table, by disease, as the report draws it: only diseases with at least five tumours, plus this tumour's own, highest median first, with some disease labels merged (OSOS and CHOS as OS, MFH as US, LIHB as HBL). Each box spans the middle half of a disease's tumours, the line in it is the median, the whiskers reach the furthest tumours within one and a half box-lengths, and each dot is one tumour. The pin is this tumour; hover a disease for its numbers and, in the tumour's own disease, where it ranks.","The cohort is the one the report compared with when it ran. It does not grow as the project does; rerun the report to compare with the cohort as it is now."]},{heading:"Reading and moving around",terms:[["Hover a segment","Its call, copies (major + minor), coordinates and, when available, log2 ratio. A readout at the foot of the plot gives the pointer's place on the genome."],["Click a segment","Lists the mutations inside it in the Mutations card."],["Click a driver","Finds that gene in the Mutations card."],["Scroll up or down over the plot","Zooms around the pointer: up zooms in, down zooms out (two fingers on a trackpad, or a mouse wheel). A pinch zooms too. A scroll that starts outside the plot keeps scrolling the page, and once the whole genome is in view, scrolling down scrolls the page again."],["Scroll sideways, or drag","Pans a zoomed view (two fingers sideways on a trackpad, or Shift and a mouse wheel)."],["Arrow keys, plus and minus, 0","With the plot focused: pan, zoom in and out, and show the whole genome."],["Double-click a chromosome, or click its name","Glides to fill the view with it; the strip then counts megabases."],["The overview","The whole genome in miniature under the strip. Its window shows where the plot is: drag the window to move, its ends to resize, or click elsewhere to centre it there. The button by the title returns to the whole genome."],["Hover a mutation in the table","Marks it here, with a ring on the segment it sits on and its copy number."]]},{heading:"Tumour-only reports",paragraphs:["Without a matched normal there is no ploidy estimate, so segments come from CNVkit and are called against two copies. Allele-specific copy numbers are not available."]}]},mutations:{title:"Mutations",intro:"The tumour's somatic SNVs and indels that passed the callers' filters: how they are distributed across cancer cells, and a searchable, filterable table of every call.",sections:[{heading:"Which mutations",terms:[["Drivers","Likely drivers flagged by the report: coding mutations that match OncoKB or COSMIC driver annotations (the exact protein change, or a damaging consequence in a known cancer gene), plus known hotspots the callers missed and the report recovered from the tumour's reads."],["Coding","Mutations whose effect changes a protein, by the report's list of coding effects."],["All","Every PASS SNV and indel."]],paragraphs:["The counts beside each choice follow the search and filters, so they always say what you would see."]},{heading:"FFPE samples",paragraphs:["Formalin-fixed (FFPE) tissue damages DNA in ways that look like mutations, mostly C>T changes at low allele fractions. For an FFPE sample, FFPERASE scores each SNV and indel for how likely it is to be such an artifact, and the report counts only the calls scored at or below its threshold (quoted beside the table). Its SNV, indel and coding totals and the TMB leave the rest out.",`The report marks each call it leaves out, and the dashboard follows that mark: the Coding and All counts, the table and the curve leave those calls out, and the card's subtitle says so. Drivers are all listed, as in the report, and any the filter would remove carry an "FFPE filtered" tag. "Show filtered calls", under FFPE filter beside the table, brings the removed calls back, tagged the same way.`]},{heading:"Cancer cell fraction and variant allele fraction",paragraphs:["The curve across the top is a smoothed histogram of every PASS mutation; driver mutations sit on it as labelled dots, and the diamond on the axis is the median. Switch between the two measures:"],terms:[["CCF",'Cancer cell fraction: the estimated share of cancer cells carrying the mutation, corrected for purity and copy number. Around 1 (the "clonal" mark) means nearly every cancer cell has it, which suggests it arose early; clearly below 1 means a subclone. Estimates can land somewhat above 1. Shown from 0 to 2.'],["VAF","Variant allele fraction: the share of sequencing reads at the position that carry the mutation, from 0 to 1. Raw, not corrected for purity or copy number. Tumour-only reports open on VAF, since CCF needs a matched normal."]]},{heading:"Filtering by the curve",paragraphs:["Drag across the curve to keep only mutations in that CCF or VAF range: the curve stays lit inside the range and fades outside it, and the range is read out at its foot. Drag the edges to resize it, or its body to move it. The range appears with the other filters and can be removed there, or by clicking the curve."]},{heading:"Coding mutations against reference cohorts",paragraphs:["At the foot of the card, the tumour's coding SNVs and indels set against reference tumours of the same disease, as the report's TMB figure draws them: Grobner and colleagues' published pan-cancer cohort, where the disease has a match there, and MSK's TMB reference project. Each cohort is a violin cut at its smallest and largest tumour; two cohorts share one violin, one on each side. The bar inside marks the middle half and the circle the median. The line across is this tumour; hover a cohort for its numbers and where the tumour ranks.","Counts are coding mutations as the report counts them (after the FFPE filter for FFPE samples), the same numbers as the Coding tab. The MSK cohort leaves out tumours far above its 99th percentile, as the report does. The cohorts are the ones the report compared with when it ran; rerun the report to compare with them as they are now."]},{heading:"The table",terms:[["Gene and position","The gene, and the mutation's chromosome and position (GRCh37)."],["Change","The protein change, with the cDNA change beneath."],["Effect","What the mutation does to the gene, from the VEP consequence (or the report's effect). Truncating effects are in bold."],["VAF and CCF bars","The value with a bar for quick comparison; the CCF bar's tick marks 1, clonal."],["Driver","Flagged as a likely driver (shown when the table is not already limited to drivers)."],["Hotspot","The exact protein change is a known recurrent cancer hotspot."],["In DMP","The same mutation was also found by the patient's clinical MSK-IMPACT (DMP) sequencing."],["FFPE filtered","FFPE samples only: the report's FFPE artifact filter leaves this call out of its counts (see FFPE samples)."]]},{heading:"Opening a row",terms:[["Variant","SNV or indel, with the reference and alternate bases."],["Reads","Reads supporting the mutation out of all reads at the position. Only hotspots the report recovered from the tumour's reads have them; the callers' tables give no single count."],["Normal VAF","The mutation's allele fraction in the matched normal; near 0 for a somatic mutation."],["Mutant copies","How many copies of that part of the genome carry the mutation, out of all copies there."],["Consequence","The full VEP consequence."],["COSMIC","How many samples in COSMIC carry it, and how closely they match (exact change, same position, codon or gene)."],["Expression","The gene's expression in the tumour's RNA, in transcripts per million, when RNA was sequenced."],["Gene role","Whether the gene is a known oncogene or tumour suppressor gene (TSG)."],["Show on copy number","Zooms the Copy number card to the mutation's chromosome and marks it."]]},{heading:"Searching and filtering",paragraphs:["Search takes a gene, a protein or cDNA change, a COSMIC term, or a locus such as chr12:25,398,284 or a range such as chr8:1-50,000,000. Press / anywhere on the page to jump to it. Each filter's count is how many rows you would get by ticking it, given everything else."],terms:[["Missense","One amino acid replaced by another."],["Truncating","Stop gained or lost, start lost, or a frameshift."],["Splice","Changes a splice site or splice region."],["In-frame","Inserts or deletes amino acids without shifting the reading frame."],["Synonymous","Changes the DNA but not the amino acid."],["Other","Everything else, such as intronic, UTR or upstream changes."]]}]},structuralVariants:{title:"Structural variants",intro:"The tumour's rearrangements as the report shows them: those with a breakpoint in an oncogene or tumour suppressor, those that take in a whole gene, and how all of them group into rearrangement signatures.",sections:[{heading:"Which rearrangements",paragraphs:["The report works from the high-confidence structural variants of ANNOT_SVS, which keeps calls made by two or more callers (SvABA, BRASS and GRIDSS) and annotates the genes they touch with AnnotSV. The count beside the title is how many of these the report counts, its rearrangements total.",`The tables keep the rearrangements whose genes include an oncogene or tumour suppressor, by the report's gene lists. It also searches the callers' raw calls for known rearrangements the high-confidence set can miss, such as CIC fusions, and adds them; a rescued event that is not a two-caller PASS says so in its callers, as in "gridss (CIC rescued)".`]},{heading:"The two tables",terms:[["Rearranged oncogenes and tumour suppressors",'One row per rearrangement and gene it hits, with the gene and breakpoint on each side. A gene near a breakpoint rather than in it is named as the report names it, such as "TERT +/- 100Kb".'],["Whole-gene rearrangements","Rearrangements that take in a whole oncogene or tumour suppressor, from start to end: a deletion of the whole gene, for example."],["Role","Whether the row's genes include an oncogene, a tumour suppressor or both, as the report colours its rows. Click a role above the tables to show only its rows."],["Left and right","Each breakpoint's gene, position (GRCh37) and where it falls in the gene, as AnnotSV writes it (intron5, exon2-exon5). Breakpoints are ordered by chromosome, then position."],["Callers and support","The callers that made the call, and the most reads any of them gives in support."],["Pileups","Supporting reads over all reads at each breakpoint in the tumour's alignments, left then right."],["Expression","For tumours with RNA: whether each gene's expression is high or low against each expression cohort (p63 is cohort project 63): at or above its 90th percentile, at or below its 10th, or neither (None). N/A means the cohort has no value for the gene."]],paragraphs:["Open a row to see both breakpoints, show them on the copy-number card, or copy their IGV loci."]},{heading:"Rearrangement signatures",paragraphs:["WGSPOST groups the tumour's rearrangements the way rearrangement signatures are described: clustered (rearrangements that sit unusually close together, as in chromothripsis) or dispersed, then by class and, except for translocations, by size from under 1 kb to over 1 Mb. Each bar is how many rearrangements fall in a group, grouped under its class; lighter bars are the clustered ones, in the shaded zone. A group with none shows a short stub on the baseline. Hover a bar for its name and its share of all rearrangements, or a class in the key to light its bars.","WGSPOST counts from its own copy of the calls, so its total can differ slightly from the report's rearrangements count."],terms:[["Deletion","A stretch of the genome lost between two breakpoints."],["Tandem duplication","A stretch copied next to itself."],["Inversion","A stretch turned around in place."],["Translocation","A join between two chromosomes."]]}]},circos:{title:"Integrated circos",intro:"The tumour's whole genome on one circle, as WGSPOST's integrated circos draws it: every SNV, indel, copy-number change and rearrangement, from the outside in, with the counts beside it.",sections:[{heading:"The rings, from the outside in",terms:[["Drivers","Genes with likely driver mutations, outside the circle, as the Mutations card flags them."],["Chromosomes","1 to 22 and X, clockwise from the top, each in proportion to its length (GRCh37). Y is left out, as in WGSPOST's figure."],["SNV rainfall","One dot per SNV the report counts, coloured by its substitution (in the pyrimidine context). Its distance from the centre is the distance to the SNV before it on the chromosome, on a log scale: the rings mark 100 bp, 10 kb and 1 Mb. Mutations far apart sit near the outside; clusters, such as kataegis, fall inwards."],["Insertions and deletions","Two thin rings of ticks: insertions, then deletions, coloured by the mechanism WGSPOST's microhomology and repeat callers assign (complex indels are grey)."],["Copy number","Gains of the major allele, darker for more copies (2 to 3, 4 to 7, 8 or more), then loss of heterozygosity, where the minor allele has no copies. From Battenberg (CNVkit for tumour-only reports)."],["Rearrangements","Links across the middle, coloured by class as in the Structural variants card: deletions, tandem duplications, inversions and translocations."]]},{heading:"Reading it",paragraphs:["Click a chromosome to open it out to a large share of the circle, with its megabases counted inside the ring; click it again to close it. Hover a dot, a tick or a link for its details, and a chromosome for its counts. Hover a bar beside the circle to light its calls on it: a substitution, an indel kind or a rearrangement class. The buttons above the circle hide and show each track.","The circle is drawn from the same calls as the rest of the report (WGSPOST builds its figure from them too), so its counts match the Mutations and Structural variants cards. The indel kinds are WGSPOST's own classification of its indels."]}]},cnsv:{title:"Copy number and rearrangements by chromosome",intro:"One chromosome at a time, the evidence behind the copy-number calls set against the rearrangements, as WGSPOST's CN/SV integration figures show it; and Battenberg's raw data for the tumour and its normal.",sections:[{heading:"The CN/SV view, from the top",terms:[["BAF","The B-allele frequency of each heterozygous SNP in the tumour, after Battenberg's phasing (its corrected phased BAF). Balanced copies sit at 0.5; a gain or a loss pulls the SNPs of a segment away from it."],["Segments","Battenberg's copy-number segments, drawn at their BAF and labelled with their allele copies and the share of cells that carry them (“2+1: 64%” means two copies of one allele and one of the other, in 64% of cells). Green when every cell carries the state; red when it is subclonal, with the second state below."],["Rearrangements","Arcs join the two ends of a rearrangement within the chromosome: deletions and tandem duplications on the upper lane, inversions on the lower, coloured by class as in the Structural variants card. An arrow marks an end whose partner is on another chromosome, labelled with that chromosome. Faint lines drop from each end to the copy number below it, where a breakpoint often meets a step."],["Copy number","BRASS's read-depth copy number, averaged in 100 kb windows as the report's figure does, over alternating whole-copy bands. The dashed line is Battenberg's total copy number for the same stretch, green or red as its segment."]]},{heading:"Battenberg raw",paragraphs:["Battenberg's input data, as its Tumor and Germline figures show it: the LogR (read depth against the normal, on a log scale) and BAF of the tumour, then of the normal, at SNP loci across the chromosome or the whole genome. Homozygous loci sit at 0 and 1 in the BAF; the normal's heterozygous SNPs gather at 0.5."]},{heading:"Reading it",paragraphs:["Pick a chromosome above the plot; chromosomes with data stand out. Scroll up or down over the plot to zoom around the pointer (up zooms in), sideways or drag to pan, double-click to zoom in, and click a rearrangement to fit it in view; the arrow keys, plus, minus and 0 work too. Hover anywhere for the segment, its state and the read depth at that point, or a rearrangement for its ends.","Points are thinned to evenly spaced SNPs, at most 10,000 per chromosome (1,500 across the genome), so the shape of the data is kept while the page stays fast. The report shows the same figures as images, so there is nothing here to compare against it number by number."]}]},signaturesHrd:{title:"Signatures and HRD",intro:"Which mutational processes left their mark on the tumour, set against tumours of the same disease, and whether it shows homologous recombination deficiency (HRD), as the report shows them.",sections:[{heading:"Mutational signatures",paragraphs:["WGSPOST fits known COSMIC substitution signatures to the tumour's somatic SNVs and estimates how many mutations each one accounts for. The left column is this tumour: each band is a signature's share of its mutations, the largest first.","The right column is the average of tumours of the same disease in the cohort (n is how many), each tumour's shares averaged and scaled to the cohort's average mutation count. A ribbon joins each signature's two bands, widening or narrowing with its share, so a signature can be followed from the tumour to its cohort; a label on the ribbon says how many percentage points the tumour leads or trails the cohort by, where the difference is at least 5. Hover a band, a ribbon or a row of the table for the numbers.","Seven signatures get colours of their own (eight when there are no more than eight); any beyond that are drawn together as Other. A tumour without a cohort to compare shows its own shares as one column."],terms:[["Signature","A pattern of substitutions, by the base change and its neighbours, that a mutational process leaves (SBS1, SBS5)."],["Aetiology","The process the report links a signature to, when it names one."]]},{heading:"96 mutational contexts",paragraphs:["Every substitution is one of six kinds (C>A, C>G, C>T, T>A, T>C, T>G, naming the pyrimidine base of the pair) and sits between two neighbouring bases, which gives 96 contexts. The top panel counts the tumour's SNVs in each, as WGSPOST's MutationalPatterns step does. The middle panel is what the fitted signatures rebuild: each signature's probabilities for the 96 contexts, weighted by its contribution above and added up. The bottom panel is the first minus the second, so a bar above the line is a context with more SNVs than the signatures explain.","Share draws each profile as percentages of its own total, which is how the report's figure compares the two; Count draws SNVs. Both profiles share one scale, and the difference its own. Click a class in the header to open it and name its sixteen contexts, written as the base before, the mutated base in colour, and the base after. Hover a column to read all three panels at once.","Cosine similarity and RSS are the report's own measures of the fit: the closer to 1 (cosine) and to 0 (RSS), the better the signatures explain the tumour. They are computed by the report from the relative profiles, as MutationalPatterns does. For an FFPE sample, switch between the run the report uses (its FFPE-filtered calls) and the unfiltered one. When the report did not include the signature matrix its fit used, only the observed profile is drawn."]},{heading:"HRD scores",paragraphs:["Two classifiers estimate whether the tumour has lost homologous recombination repair, as BRCA1 or BRCA2 loss does: HRDetect, from the substitution, indel and rearrangement patterns below, and CHORD, from its own set of mutation features. The report rates each HIGH at or above its threshold and LOW below it; the line on each gauge is the threshold."]},{heading:"HRDetect features",paragraphs:["The six features HRDetect weighs, for every tumour in the cohort and this one, each scaled from 0 (the cohort's lowest) to 1 (its highest). Each row is one feature: the pin is this tumour, the dots beneath are the cohort's samples, the shaded band is the middle half of the cohort and the line in it the median. With eight or more cohort samples a smoothed outline of how the samples are spread is drawn above the dots; with fewer it is left out, because it would suggest more than the data says. The words at the right say how many of the other cohort samples the tumour is above. Hover a row for the unscaled value. For FFPE samples the tumour's values come from its FFPE-filtered analysis."],terms:[["Del. MH","The share of deletions with microhomology at their ends, a sign of repair by end joining."],["SBS3 and SBS8","Substitution signatures 3 and 8."],["RS3 and RS5","Rearrangement signatures 3 (small tandem duplications) and 5 (deletions)."],["HRD index","Loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions, combined."]]}]}},XC={summary:{BATTENBERG:"Tumour purity and ploidy, and the copy-number segments the ring's gains and losses are called from.","BATTENBERG cohort":"Project-wide Battenberg tables, which hold the FGA value and the cohort it is compared with.",CNV_UNMATCHED:"Copy-number segments of a tumour-only report (CNVkit), which the ring's gains and losses are called from.",MOSDEPTH:"The median sequencing coverage.",MSISENSOR:"The MSI score.",MSISENSOR_UNMATCHED:"The MSI score of a tumour-only report.",ANNOT_SNVS:"Somatic SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS:"Somatic indel calls: their count goes into TMB, and driver indels are marked on the ring.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls: their count goes into TMB, and driver indels are marked on the ring.",WGSPOST:"Cancer cell fractions of the mutations, read together with the driver calls marked on the ring."},copyNumber:{BATTENBERG:"Every segment drawn: total copies, major and minor allele copies, and the ploidy the baseline is rounded from.","BATTENBERG cohort":"Project-wide Battenberg tables of FGA: the tumour's own FGA, and the cohort the FGA figure compares it with, as it was when the report ran.",CNV_UNMATCHED:"The segments of a tumour-only report (CNVkit), drawn against two copies."},mutations:{ANNOT_SNVS:"The tumour's PASS somatic SNVs and their annotation: gene, protein and cDNA change, effect, VAF, read counts, normal VAF and COSMIC.","ANNOT_SNVS cohort":"The TMB reference project's coding SNVs: MSK's reference tumours for the disease, counted for the TMB figure, as they were when the report ran.","ANNOT_INDELS cohort":"The TMB reference project's coding indels, counted for the TMB figure like its SNVs.",ANNOT_INDELS:"The tumour's PASS somatic indels and their annotation, as for SNVs.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls and their annotation.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls and their annotation.",WGSPOST:"Each mutation's cancer cell fraction (CCF) and how many copies carry it.",BATTENBERG:"Ploidy, which fills in the copy count where WGSPOST has none, and purity, which gives a CCF to hotspots recovered from the tumour's reads.",FFPERASE_SNVS:"FFPE samples: each SNV's artifact score. Calls scoring above the report's threshold are left out of the counts.",FFPERASE_INDELS:"FFPE samples: each indel's artifact score. Calls scoring above the report's threshold are left out of the counts."},structuralVariants:{ANNOT_SVS:"The high-confidence structural variants and their AnnotSV gene annotation: the rearrangements the report counts and the rows of its tables.",ANNOT_SVS_UNMATCHED:"Tumour-only structural variants and their annotation, kept when rare in the population.",SVABA:"Raw SvABA calls, searched for known rearrangements the high-confidence set missed (rescued events).",GRIDSS:"Raw GRIDSS calls, searched for rescued events like SvABA's.",SVABA_UNMATCHED:"Raw tumour-only SvABA calls, searched for rescued events.",GRIDSS_UNMATCHED:"Raw tumour-only GRIDSS calls, searched for rescued events.",WGSPOST:"The rearrangement-signature counts.",WGSPOST_UNMATCHED:"The rearrangement-signature counts of a tumour-only report."},circos:{ANNOT_SNVS:"The SNVs of the rainfall, with their positions and substitutions.",ANNOT_SNVS_UNMATCHED:"The tumour-only SNVs of the rainfall.",WGSPOST:"The indel classification behind the indel rings (microhomology, repeat or other), and the signature contributions beside the circle.",WGSPOST_UNMATCHED:"The indel classification of a tumour-only report.",BATTENBERG:"The copy-number rings: major and minor allele copies of each segment, and the purity and ploidy beside the circle.",CNV_UNMATCHED:"The copy number of a tumour-only report (CNVkit).",ANNOT_SVS:"The rearrangements drawn across the middle.",ANNOT_SVS_UNMATCHED:"The tumour-only rearrangements drawn across the middle."},cnsv:{BATTENBERG:"The BAF per SNP, the segments with their allele states, and the raw tumour and normal LogR and BAF.",BRASS:"The read-depth copy number in 100 kb windows.",ANNOT_SVS:"The rearrangements drawn as arcs and arrows."},signaturesHrd:{WGSPOST:"The tumour's signature contributions, its SNV counts in the 96 mutational contexts, its HRDetect and CHORD scores, and its HRDetect features.",WGSPOST_FFPE:"For an FFPE sample, the same from the FFPE-filtered calls.","WGSPOST 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+ * @license lucide-react v0.468.0 - ISC
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+ *
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+ * This source code is licensed under the ISC license.
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+ * See the LICENSE file in the root directory of this source tree.
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+ */const CC=Oe("UserRound",[["circle",{cx:"12",cy:"8",r:"5",key:"1hypcn"}],["path",{d:"M20 21a8 8 0 0 0-16 0",key:"rfgkzh"}]]);/**
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+ * @license lucide-react v0.468.0 - ISC
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+ *
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+ * This source code is licensed under the ISC license.
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+ * See the LICENSE file in the root directory of this source tree.
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+ */const MC=Oe("Users",[["path",{d:"M16 21v-2a4 4 0 0 0-4-4H6a4 4 0 0 0-4 4v2",key:"1yyitq"}],["circle",{cx:"9",cy:"7",r:"4",key:"nufk8"}],["path",{d:"M22 21v-2a4 4 0 0 0-3-3.87",key:"kshegd"}],["path",{d:"M16 3.13a4 4 0 0 1 0 7.75",key:"1da9ce"}]]);/**
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+ * @license lucide-react v0.468.0 - ISC
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+ *
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+ * This source code is licensed under the ISC license.
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+ * See the LICENSE file in the root directory of this source tree.
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+ * @license lucide-react v0.468.0 - ISC
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+ *
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+ * This source code is licensed under the ISC license.
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+ * See the LICENSE file in the root directory of this source tree.
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+ */const ec=Oe("X",[["path",{d:"M18 6 6 18",key:"1bl5f8"}],["path",{d:"m6 6 12 12",key:"d8bk6v"}]]);/**
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+ * @license lucide-react v0.468.0 - ISC
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+ *
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+ * This source code is licensed under the ISC license.
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+ * See the LICENSE file in the root directory of this source tree.
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+ */const Sy=Oe("ZoomOut",[["circle",{cx:"11",cy:"11",r:"8",key:"4ej97u"}],["line",{x1:"21",x2:"16.65",y1:"21",y2:"16.65",key:"13gj7c"}],["line",{x1:"8",x2:"14",y1:"11",y2:"11",key:"durymu"}]]);function RC(n){if(n.value===null)return n.text??"";switch(n.key){case"coverage":return`${Math.round(n.value)}×`;case"tmb":return n.value<.01?n.value.toPrecision(2):n.value.toFixed(2);default:return n.value.toFixed(2)}}function TC(n){return n.status==="failed"?"Failed":n.status==="skipped"?"Not in this mode":"Not run"}const _C=new Intl.DateTimeFormat("en-GB",{day:"numeric",month:"short",year:"numeric"});function jy(n){if(!n)return"";const a=new Date(n);return Number.isNaN(a.getTime())?"":_C.format(a)}function eo(n,a){return n.startsWith(`${a}_`)?n.slice(a.length+1):n}function ng(n){return n==null?"–":n.toFixed(2)}const wv={missense_variant:"Missense",stop_gained:"Nonsense",stop_lost:"Stop lost",start_lost:"Start lost",frameshift_variant:"Frameshift",inframe_deletion:"In-frame 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fingerprint and summary",intro:"A one-glance portrait of the selected tumour: its copy-number changes and driver mutations drawn as a ring, a sentence describing them, and the headline measurements of the sample.",sections:[{heading:"The fingerprint ring",paragraphs:["The ring is the whole genome. Chromosome 1 starts at the top and the ring runs clockwise through chromosome 22 to X, each chromosome's arc in proportion to its length (GRCh37).","Copy-number changes are called against the tumour's baseline, its ploidy rounded to whole copies. Very short changes are drawn at a minimum length so they stay visible."],terms:[["Gains (outer track, orange)","Regions with at least one copy more than the baseline."],["Amplifications (outer track, darker and thicker)","Regions with three or more copies above the baseline."],["Losses (inner track, blue)","Regions with at least one copy fewer than the baseline."],["Drivers (black ticks)","Where the tumour's likely driver mutations sit (see the Mutations card for how they are flagged)."]]},{heading:"The sentence",paragraphs:["Written from the same data as the ring: how many amplifications, gains and losses there are and on which chromosomes, and which genes carry driver mutations."]},{heading:"The measurements",paragraphs:["Each tile shows a value, a small picture of where it sits on its scale when it has a natural one, and the analysis it came from. A tile with no value says why: the analysis was not run, it failed, or it does not apply to this kind of report (tumour-only reports have no matched normal)."],terms:[["Purity","The estimated fraction of cells in the sample that are tumour cells, from 0 to 1. The ring fills to the value."],["Ploidy","The tumour's average number of copies across the genome. The scale runs from 1 to 6 copies; the tall tick marks 2, a diploid genome."],["Coverage","The median sequencing depth of the tumour across the genome, in reads (×)."],["TMB per Mb","Tumour mutational burden: somatic SNVs and indels per megabase of genome. The report computes it from the counts of the SNV and indel calls. The scale is logarithmic, 0.01 to 100."],["MSI score","The MSIsensor score: the percentage of microsatellite sites that look unstable in the tumour."],["FGA","Fraction of the genome altered: the share of the genome whose copy number differs from the baseline, from 0 to 1. It is read from the project-wide Battenberg tables."]]},{heading:"Linking back to the analyses",paragraphs:[`Every value names its analysis, with version and Isabl id. Picking an analysis in the side menu's "Analyses on this page" highlights the tiles and cards it feeds.`]}]},copyNumber:{title:"Copy number",intro:"How many copies of each part of the genome the tumour carries, segment by segment, from chromosome 1 to X.",sections:[{heading:"What is drawn",paragraphs:['Each horizontal stroke is one segment: a stretch of the genome with a constant copy number. Its height is the number of copies, from 0 up to 8; anything higher is drawn at the top and the axis reads "8+". A gain or amplification rises as a column from the baseline to its stroke, and a loss falls to it, so the changes read as a landscape. Alternating grey bands mark the chromosomes, named in a strip along the bottom.',`The line across the plot is the baseline: the tumour's ploidy rounded to whole copies (labelled, for example, "2 copies"). Segments are coloured by how they compare with it.`],terms:[["Grey","Neutral: the same number of copies as the baseline."],["Orange","Gain: at least one copy more than the baseline."],["Dark orange","Amplification: three or more copies above the baseline."],["Blue","Loss: at least one copy fewer than the baseline."]]},{heading:"Total or allele-specific",paragraphs:["Total shows all copies together. Allele-specific, when the analysis provides it, splits each segment into its major allele (the more common parental copy, dark) and minor allele (light). Where the two are equal they are drawn slightly apart so both stay visible. A minor allele of 0 means one parent's copy is lost there (loss of heterozygosity)."]},{heading:"Driver genes",paragraphs:["A label along the top names each gene with likely driver mutations, one per gene, joined by a line to a dot on the segment the gene sits on, so its copy number can be read off at once. Hover one for its protein changes and the copies there."]},{heading:"Amplified and lost genes",paragraphs:["The oncogenes the report calls amplified and the tumour suppressors it calls homozygously lost, from the copy number over each gene, in chromosome order. The row of cells shows the copy number (all eight filled means eight copies or more). When the sample has RNA, each gene also shows its expression against each expression cohort: the log2 of this sample's level over the cohort's mean, so +1 is twice the cohort's level. Point at a gene to mark it on the plot; click it to glide to its chromosome."]},{heading:"Fraction of genome altered against the cohort",paragraphs:["The tumour's FGA (the share of the genome whose copy number differs from the baseline) set against every tumour in the project's FGA table, by disease, as the report draws it: only diseases with at least five tumours, plus this tumour's own, highest median first, with some disease labels merged (OSOS and CHOS as OS, MFH as US, LIHB as HBL). Each box spans the middle half of a disease's tumours, the line in it is the median, the whiskers reach the furthest tumours within one and a half box-lengths, and each dot is one tumour. The pin is this tumour; hover a disease for its numbers and, in the tumour's own disease, where it ranks.","The cohort is the one the report compared with when it ran. It does not grow as the project does; rerun the report to compare with the cohort as it is now."]},{heading:"Reading and moving around",terms:[["Hover a segment","Its call, copies (major + minor), coordinates and, when available, log2 ratio. A readout at the foot of the plot gives the pointer's place on the genome."],["Click a segment","Lists the mutations inside it in the Mutations card."],["Click a driver","Finds that gene in the Mutations card."],["Scroll up or down over the plot","Zooms around the pointer: up zooms in, down zooms out (two fingers on a trackpad, or a mouse wheel). A pinch zooms too. A scroll that starts outside the plot keeps scrolling the page, and once the whole genome is in view, scrolling down scrolls the page again."],["Scroll sideways, or drag","Pans a zoomed view (two fingers sideways on a trackpad, or Shift and a mouse wheel)."],["Arrow keys, plus and minus, 0","With the plot focused: pan, zoom in and out, and show the whole genome."],["Double-click a chromosome, or click its name","Glides to fill the view with it; the strip then counts megabases."],["The overview","The whole genome in miniature under the strip. Its window shows where the plot is: drag the window to move, its ends to resize, or click elsewhere to centre it there. The button by the title returns to the whole genome."],["Hover a mutation in the table","Marks it here, with a ring on the segment it sits on and its copy number."]]},{heading:"Tumour-only reports",paragraphs:["Without a matched normal there is no ploidy estimate, so segments come from CNVkit and are called against two copies. Allele-specific copy numbers are not available."]}]},mutations:{title:"Mutations",intro:"The tumour's somatic SNVs and indels that passed the callers' filters: how they are distributed across cancer cells, and a searchable, filterable table of every call.",sections:[{heading:"Which mutations",terms:[["Drivers","Likely drivers flagged by the report: coding mutations that match OncoKB or COSMIC driver annotations (the exact protein change, or a damaging consequence in a known cancer gene), plus known hotspots the callers missed and the report recovered from the tumour's reads."],["Coding","Mutations whose effect changes a protein, by the report's list of coding effects."],["All","Every PASS SNV and indel."]],paragraphs:["The counts beside each choice follow the search and filters, so they always say what you would see."]},{heading:"FFPE samples",paragraphs:["Formalin-fixed (FFPE) tissue damages DNA in ways that look like mutations, mostly C>T changes at low allele fractions. For an FFPE sample, FFPERASE scores each SNV and indel for how likely it is to be such an artifact, and the report counts only the calls scored at or below its threshold (quoted beside the table). Its SNV, indel and coding totals and the TMB leave the rest out.",`The report marks each call it leaves out, and the dashboard follows that mark: the Coding and All counts, the table and the curve leave those calls out, and the card's subtitle says so. Drivers are all listed, as in the report, and any the filter would remove carry an "FFPE filtered" tag. "Show filtered calls", under FFPE filter beside the table, brings the removed calls back, tagged the same way.`]},{heading:"Cancer cell fraction and variant allele fraction",paragraphs:["The curve across the top is a smoothed histogram of every PASS mutation; driver mutations sit on it as labelled dots, and the diamond on the axis is the median. Switch between the two measures:"],terms:[["CCF",'Cancer cell fraction: the estimated share of cancer cells carrying the mutation, corrected for purity and copy number. Around 1 (the "clonal" mark) means nearly every cancer cell has it, which suggests it arose early; clearly below 1 means a subclone. Estimates can land somewhat above 1. Shown from 0 to 2.'],["VAF","Variant allele fraction: the share of sequencing reads at the position that carry the mutation, from 0 to 1. Raw, not corrected for purity or copy number. Tumour-only reports open on VAF, since CCF needs a matched normal."]]},{heading:"Filtering by the curve",paragraphs:["Drag across the curve to keep only mutations in that CCF or VAF range: the curve stays lit inside the range and fades outside it, and the range is read out at its foot. Drag the edges to resize it, or its body to move it. The range appears with the other filters and can be removed there, or by clicking the curve."]},{heading:"Coding mutations against reference cohorts",paragraphs:["At the foot of the card, the tumour's coding SNVs and indels set against reference tumours of the same disease, as the report's TMB figure draws them: Grobner and colleagues' published pan-cancer cohort, where the disease has a match there, and MSK's TMB reference project. Each cohort is a violin cut at its smallest and largest tumour; two cohorts share one violin, one on each side. The bar inside marks the middle half and the circle the median. The line across is this tumour; hover a cohort for its numbers and where the tumour ranks.","Counts are coding mutations as the report counts them (after the FFPE filter for FFPE samples), the same numbers as the Coding tab. The MSK cohort leaves out tumours far above its 99th percentile, as the report does. The cohorts are the ones the report compared with when it ran; rerun the report to compare with them as they are now."]},{heading:"The table",terms:[["Gene and position","The gene, and the mutation's chromosome and position (GRCh37)."],["Change","The protein change, with the cDNA change beneath."],["Effect","What the mutation does to the gene, from the VEP consequence (or the report's effect). Truncating effects are in bold."],["VAF and CCF bars","The value with a bar for quick comparison; the CCF bar's tick marks 1, clonal."],["Driver","Flagged as a likely driver (shown when the table is not already limited to drivers)."],["Hotspot","The exact protein change is a known recurrent cancer hotspot."],["In DMP","The same mutation was also found by the patient's clinical MSK-IMPACT (DMP) sequencing."],["FFPE filtered","FFPE samples only: the report's FFPE artifact filter leaves this call out of its counts (see FFPE samples)."]]},{heading:"Opening a row",terms:[["Variant","SNV or indel, with the reference and alternate bases."],["Reads","Reads supporting the mutation out of all reads at the position. Only hotspots the report recovered from the tumour's reads have them; the callers' tables give no single count."],["Normal VAF","The mutation's allele fraction in the matched normal; near 0 for a somatic mutation."],["Mutant copies","How many copies of that part of the genome carry the mutation, out of all copies there."],["Consequence","The full VEP consequence."],["COSMIC","How many samples in COSMIC carry it, and how closely they match (exact change, same position, codon or gene)."],["Expression","The gene's expression in the tumour's RNA, in transcripts per million, when RNA was sequenced."],["Gene role","Whether the gene is a known oncogene or tumour suppressor gene (TSG)."],["Show on copy number","Zooms the Copy number card to the mutation's chromosome and marks it."]]},{heading:"Searching and filtering",paragraphs:["Search takes a gene, a protein or cDNA change, a COSMIC term, or a locus such as chr12:25,398,284 or a range such as chr8:1-50,000,000. Press / anywhere on the page to jump to it. Each filter's count is how many rows you would get by ticking it, given everything else."],terms:[["Missense","One amino acid replaced by another."],["Truncating","Stop gained or lost, start lost, or a frameshift."],["Splice","Changes a splice site or splice region."],["In-frame","Inserts or deletes amino acids without shifting the reading frame."],["Synonymous","Changes the DNA but not the amino acid."],["Other","Everything else, such as intronic, UTR or upstream changes."]]}]},structuralVariants:{title:"Structural variants",intro:"The tumour's rearrangements as the report shows them: those with a breakpoint in an oncogene or tumour suppressor, those that take in a whole gene, and how all of them group into rearrangement signatures.",sections:[{heading:"Which rearrangements",paragraphs:["The report works from the high-confidence structural variants of ANNOT_SVS, which keeps calls made by two or more callers (SvABA, BRASS and GRIDSS) and annotates the genes they touch with AnnotSV. The count beside the title is how many of these the report counts, its rearrangements total.",`The tables keep the rearrangements whose genes include an oncogene or tumour suppressor, by the report's gene lists. It also searches the callers' raw calls for known rearrangements the high-confidence set can miss, such as CIC fusions, and adds them; a rescued event that is not a two-caller PASS says so in its callers, as in "gridss (CIC rescued)".`]},{heading:"The two tables",terms:[["Rearranged oncogenes and tumour suppressors",'One row per rearrangement and gene it hits, with the gene and breakpoint on each side. A gene near a breakpoint rather than in it is named as the report names it, such as "TERT +/- 100Kb".'],["Whole-gene rearrangements","Rearrangements that take in a whole oncogene or tumour suppressor, from start to end: a deletion of the whole gene, for example."],["Role","Whether the row's genes include an oncogene, a tumour suppressor or both, as the report colours its rows. Click a role above the tables to show only its rows."],["Left and right","Each breakpoint's gene, position (GRCh37) and where it falls in the gene, as AnnotSV writes it (intron5, exon2-exon5). Breakpoints are ordered by chromosome, then position."],["Callers and support","The callers that made the call, and the most reads any of them gives in support."],["Pileups","Supporting reads over all reads at each breakpoint in the tumour's alignments, left then right."],["Expression","For tumours with RNA: whether each gene's expression is high or low against each expression cohort (p63 is cohort project 63): at or above its 90th percentile, at or below its 10th, or neither (None). N/A means the cohort has no value for the gene."]],paragraphs:["Open a row to see both breakpoints, show them on the copy-number card, or copy their IGV loci."]},{heading:"Rearrangement signatures",paragraphs:["WGSPOST groups the tumour's rearrangements the way rearrangement signatures are described: clustered (rearrangements that sit unusually close together, as in chromothripsis) or dispersed, then by class and, except for translocations, by size from under 1 kb to over 1 Mb. Each bar is how many rearrangements fall in a group, grouped under its class; lighter bars are the clustered ones, in the shaded zone. A group with none shows a short stub on the baseline. Hover a bar for its name and its share of all rearrangements, or a class in the key to light its bars.","WGSPOST counts from its own copy of the calls, so its total can differ slightly from the report's rearrangements count."],terms:[["Deletion","A stretch of the genome lost between two breakpoints."],["Tandem duplication","A stretch copied next to itself."],["Inversion","A stretch turned around in place."],["Translocation","A join between two chromosomes."]]}]},circos:{title:"Integrated circos",intro:"The tumour's whole genome on one circle, as WGSPOST's integrated circos draws it: every SNV, indel, copy-number change and rearrangement, from the outside in, with the counts beside it.",sections:[{heading:"The rings, from the outside in",terms:[["Drivers","Genes with likely driver mutations, outside the circle, as the Mutations card flags them."],["Chromosomes","1 to 22 and X, clockwise from the top, each in proportion to its length (GRCh37). Y is left out, as in WGSPOST's figure."],["SNV rainfall","One dot per SNV the report counts, coloured by its substitution (in the pyrimidine context). Its distance from the centre is the distance to the SNV before it on the chromosome, on a log scale: the rings mark 100 bp, 10 kb and 1 Mb. Mutations far apart sit near the outside; clusters, such as kataegis, fall inwards."],["Insertions and deletions","Two thin rings of ticks: insertions, then deletions, coloured by the mechanism WGSPOST's microhomology and repeat callers assign (complex indels are grey)."],["Copy number","Gains of the major allele, darker for more copies (2 to 3, 4 to 7, 8 or more), then loss of heterozygosity, where the minor allele has no copies. From Battenberg (CNVkit for tumour-only reports)."],["Rearrangements","Links across the middle, coloured by class as in the Structural variants card: deletions, tandem duplications, inversions and translocations."]]},{heading:"Reading it",paragraphs:["Click a chromosome to open it out to a large share of the circle, with its megabases counted inside the ring; click it again to close it. Hover a dot, a tick or a link for its details, and a chromosome for its counts. Hover a bar beside the circle to light its calls on it: a substitution, an indel kind or a rearrangement class. The buttons above the circle hide and show each track.","The circle is drawn from the same calls as the rest of the report (WGSPOST builds its figure from them too), so its counts match the Mutations and Structural variants cards. The indel kinds are WGSPOST's own classification of its indels."]}]},cnsv:{title:"Copy number and rearrangements by chromosome",intro:"One chromosome at a time, the evidence behind the copy-number calls set against the rearrangements, as WGSPOST's CN/SV integration figures show it; and Battenberg's raw data for the tumour and its normal.",sections:[{heading:"The CN/SV view, from the top",terms:[["BAF","The B-allele frequency of each heterozygous SNP in the tumour, after Battenberg's phasing (its corrected phased BAF). Balanced copies sit at 0.5; a gain or a loss pulls the SNPs of a segment away from it."],["Segments","Battenberg's copy-number segments, drawn at their BAF and labelled with their allele copies and the share of cells that carry them (“2+1: 64%” means two copies of one allele and one of the other, in 64% of cells). Green when every cell carries the state; red when it is subclonal, with the second state below."],["Rearrangements","Arcs join the two ends of a rearrangement within the chromosome: deletions and tandem duplications on the upper lane, inversions on the lower, coloured by class as in the Structural variants card. An arrow marks an end whose partner is on another chromosome, labelled with that chromosome. Faint lines drop from each end to the copy number below it, where a breakpoint often meets a step."],["Copy number","BRASS's read-depth copy number, averaged in 100 kb windows as the report's figure does, over alternating whole-copy bands. The dashed line is Battenberg's total copy number for the same stretch, green or red as its segment."]]},{heading:"Battenberg raw",paragraphs:["Battenberg's input data, as its Tumor and Germline figures show it: the LogR (read depth against the normal, on a log scale) and BAF of the tumour, then of the normal, at SNP loci across the chromosome or the whole genome. Homozygous loci sit at 0 and 1 in the BAF; the normal's heterozygous SNPs gather at 0.5."]},{heading:"Reading it",paragraphs:["Pick a chromosome above the plot; chromosomes with data stand out. Scroll up or down over the plot to zoom around the pointer (up zooms in), sideways or drag to pan, double-click to zoom in, and click a rearrangement to fit it in view; the arrow keys, plus, minus and 0 work too. Hover anywhere for the segment, its state and the read depth at that point, or a rearrangement for its ends.","Points are thinned to evenly spaced SNPs, at most 10,000 per chromosome (1,500 across the genome), so the shape of the data is kept while the page stays fast. The report shows the same figures as images, so there is nothing here to compare against it number by number."]}]},rna:{title:"RNA",intro:"What the tumour's RNA shows, as the report lists it: genes fused together, and cancer genes expressed far above tumours like it.",sections:[{heading:"Fusions",terms:[["Confident","Fusions ANNOT_FUSIONS is confident in, one row per gene pair: the most split and spanning reads among the pair's calls, and every caller that found it. Open a pair for its breakpoint events and every other field the report shows."],["Rescued","Fusions with less support that ANNOT_FUSIONS keeps because they involve genes known to fuse in cancer."],["Split and spanning reads","Split reads cross the junction itself; spanning read pairs have one mate on each gene. The bars compare the fusions in the list."],["Highlighted","The fusions the report colours: OncoKB calls them oncogenic or likely oncogenic, or, for calls the report grouped itself, one gene is a COSMIC fusion gene."],["Breakpoints","Click an end to show it on the copy-number plot, where a fusion's genomic breakpoint often meets a change in copy number or a rearrangement."]]},{heading:"Overexpressed cancer genes",paragraphs:["Oncogenes, tumour suppressors and COSMIC Census genes whose level in the tumour is above the 95% confidence interval of its cohort's mean and at least four times that mean (a log2 fold change over 2), as the report finds them. Tumours of blood cancers are compared with blood cancers, solid tumours with solid tumours. The bar is the log2 fold change, with the times-the-mean beside it; when the tumour belongs to several cohort projects there is one bar per project.","The cohort is as it was when the report ran; keeping it current is planned."]}]},treatments:{title:"Available treatments",intro:"Drugs OncoKB associates with the tumour's alterations, as the report lists them: its likely drivers, rearrangements, fusions and copy-number changes, and the alterations its DMP (MSK-IMPACT) test found.",sections:[{heading:"Reading the table",terms:[["Level","OncoKB's level of evidence for the association, the strongest first: 1 and 2 are standard care (FDA-recognised, or in guidelines), 3A and 3B clinical evidence, 4 biological evidence, R1 and R2 resistance. Hover the badge for OncoKB's own description."],["Alteration","The gene and the change OncoKB matched, with its kind (SNV/Indel, Fusion/SV or CNA). Click it for OncoKB's page."],["Drugs","Each option on its own: drugs joined by + are given together."],["Tumour type","The cancer type the level holds for; All Solid Tumors and similar apply across types."],["Called by","Who found the alteration: Isabl's own calls, the DMP's, or both. “Called by Isabl only” leaves out what only the DMP found."]]},{heading:"Where it comes from",paragraphs:["The report asks OncoKB for each alteration, for the tumour's disease, when it runs, and keeps one row per alteration, drug and level. OncoKB's knowledge changes over time; rerunning the report asks it again."]}]},dmp:{title:"DMP results",intro:"The patient's clinical sequencing (the DMP: MSK-IMPACT and MSK-ACCESS) as cBioPortal lists it, in the report's three tables, with each DMP mutation also looked up in the reads of every WGS tumour.",sections:[{heading:"Mutations",terms:[["DMP samples and VAF","Each DMP sample that carries the mutation, with its variant allele fraction there. The sample matched to the one you are reading (its matched IMPACT sample) is outlined. Hover a sample for its read counts."],["WGS columns","The mutation's VAF in each WGS tumour, piled up from its reads by the report, with the variant and total reads. A filled mark means the tumour's own calls include the mutation (the same rule the Mutations table uses to mark calls the DMP also made); click it on the tumour you are reading to open that call. A hollow mark means the reads were counted but the tumour has no call there. With no reads, the report shows 0."],["WGS against DMP VAF","Each mutation's VAF in the picked tumour's WGS against its DMP VAF: the matched sample's when it carries the mutation, otherwise the highest. Points near the diagonal agree. Hover a point or a row to find it in the other."]]},{heading:"SVs and CNAs",paragraphs:["Structural variants with their genes, class and event, and copy-number alterations by gene, as gains or losses, each with the DMP samples that carry them."]},{heading:"Where it comes from",paragraphs:["The report asks cBioPortal's API for the patient's DMP samples and their calls when it runs, so what is here is what cBioPortal held then; rerunning the report asks again. When cBioPortal did not answer in time, the card says which tables may be missing. cBioPortal is not an Isabl analysis, so no analyses are listed below."]}]},quality:{title:"Sample concordance",intro:"Conpair compares the patient's experiments at common germline SNPs to check that the samples come from the same person. A sample swap or mislabelling shows as a pair with low concordance.",sections:[{heading:"Reading the pairs",paragraphs:["Each row is a pair of experiments Conpair compared, with its concordance on one scale; the tick is the report's threshold. Conpair compares a pair in both directions; as the report does, each pair keeps the better of the two (hover the number for both). The report flags a pair whose concordance falls below the threshold."]}]},signaturesHrd:{title:"Signatures and HRD",intro:"Which mutational processes left their mark on the tumour, set against tumours of the same disease, and whether it shows homologous recombination deficiency (HRD), as the report shows them.",sections:[{heading:"Mutational signatures",paragraphs:["WGSPOST fits known COSMIC substitution signatures to the tumour's somatic SNVs and estimates how many mutations each one accounts for. The left column is this tumour: each band is a signature's share of its mutations, the largest first.","The right column is the average of tumours of the same disease in the cohort (n is how many), each tumour's shares averaged and scaled to the cohort's average mutation count. A ribbon joins each signature's two bands, widening or narrowing with its share, so a signature can be followed from the tumour to its cohort; a label on the ribbon says how many percentage points the tumour leads or trails the cohort by, where the difference is at least 5. Hover a band, a ribbon or a row of the table for the numbers.","Seven signatures get colours of their own (eight when there are no more than eight); any beyond that are drawn together as Other. A tumour without a cohort to compare shows its own shares as one column."],terms:[["Signature","A pattern of substitutions, by the base change and its neighbours, that a mutational process leaves (SBS1, SBS5)."],["Aetiology","The process the report links a signature to, when it names one."]]},{heading:"96 mutational contexts",paragraphs:["Every substitution is one of six kinds (C>A, C>G, C>T, T>A, T>C, T>G, naming the pyrimidine base of the pair) and sits between two neighbouring bases, which gives 96 contexts. The top panel counts the tumour's SNVs in each, as WGSPOST's MutationalPatterns step does. The middle panel is what the fitted signatures rebuild: each signature's probabilities for the 96 contexts, weighted by its contribution above and added up. The bottom panel is the first minus the second, so a bar above the line is a context with more SNVs than the signatures explain.","Share draws each profile as percentages of its own total, which is how the report's figure compares the two; Count draws SNVs. Both profiles share one scale, and the difference its own. Click a class in the header to open it and name its sixteen contexts, written as the base before, the mutated base in colour, and the base after. Hover a column to read all three panels at once.","Cosine similarity and RSS are the report's own measures of the fit: the closer to 1 (cosine) and to 0 (RSS), the better the signatures explain the tumour. They are computed by the report from the relative profiles, as MutationalPatterns does. For an FFPE sample, switch between the run the report uses (its FFPE-filtered calls) and the unfiltered one. When the report did not include the signature matrix its fit used, only the observed profile is drawn."]},{heading:"HRD scores",paragraphs:["Two classifiers estimate whether the tumour has lost homologous recombination repair, as BRCA1 or BRCA2 loss does: HRDetect, from the substitution, indel and rearrangement patterns below, and CHORD, from its own set of mutation features. The report rates each HIGH at or above its threshold and LOW below it; the line on each gauge is the threshold."]},{heading:"HRDetect features",paragraphs:["The six features HRDetect weighs, for every tumour in the cohort and this one, each scaled from 0 (the cohort's lowest) to 1 (its highest). Each row is one feature: the pin is this tumour, the dots beneath are the cohort's samples, the shaded band is the middle half of the cohort and the line in it the median. With eight or more cohort samples a smoothed outline of how the samples are spread is drawn above the dots; with fewer it is left out, because it would suggest more than the data says. The words at the right say how many of the other cohort samples the tumour is above. Hover a row for the unscaled value. For FFPE samples the tumour's values come from its FFPE-filtered analysis."],terms:[["Del. MH","The share of deletions with microhomology at their ends, a sign of repair by end joining."],["SBS3 and SBS8","Substitution signatures 3 and 8."],["RS3 and RS5","Rearrangement signatures 3 (small tandem duplications) and 5 (deletions)."],["HRD index","Loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions, combined."]]}]}},IM={summary:{BATTENBERG:"Tumour purity and ploidy, and the copy-number segments the ring's gains and losses are called from.","BATTENBERG cohort":"Project-wide Battenberg tables, which hold the FGA value and the cohort it is compared with.",CNV_UNMATCHED:"Copy-number segments of a tumour-only report (CNVkit), which the ring's gains and losses are called from.",MOSDEPTH:"The median sequencing coverage.",MSISENSOR:"The MSI score.",MSISENSOR_UNMATCHED:"The MSI score of a tumour-only report.",ANNOT_SNVS:"Somatic SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS:"Somatic indel calls: their count goes into TMB, and driver indels are marked on the ring.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls: their count goes into TMB, and driver SNVs are marked on the ring.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls: their count goes into TMB, and driver indels are marked on the ring.",WGSPOST:"Cancer cell fractions of the mutations, read together with the driver calls marked on the ring."},copyNumber:{BATTENBERG:"Every segment drawn: total copies, major and minor allele copies, and the ploidy the baseline is rounded from.","BATTENBERG cohort":"Project-wide Battenberg tables of FGA: the tumour's own FGA, and the cohort the FGA figure compares it with, as it was when the report ran.",CNV_UNMATCHED:"The segments of a tumour-only report (CNVkit), drawn against two copies."},mutations:{ANNOT_SNVS:"The tumour's PASS somatic SNVs and their annotation: gene, protein and cDNA change, effect, VAF, read counts, normal VAF and COSMIC.","ANNOT_SNVS cohort":"The TMB reference project's coding SNVs: MSK's reference tumours for the disease, counted for the TMB figure, as they were when the report ran.","ANNOT_INDELS cohort":"The TMB reference project's coding indels, counted for the TMB figure like its SNVs.",ANNOT_INDELS:"The tumour's PASS somatic indels and their annotation, as for SNVs.",ANNOT_SNVS_UNMATCHED:"Tumour-only SNV calls and their annotation.",ANNOT_INDELS_UNMATCHED:"Tumour-only indel calls and their annotation.",WGSPOST:"Each mutation's cancer cell fraction (CCF) and how many copies carry it.",BATTENBERG:"Ploidy, which fills in the copy count where WGSPOST has none, and purity, which gives a CCF to hotspots recovered from the tumour's reads.",FFPERASE_SNVS:"FFPE samples: each SNV's artifact score. Calls scoring above the report's threshold are left out of the counts.",FFPERASE_INDELS:"FFPE samples: each indel's artifact score. 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@@ -283,10 +308,10 @@ Error generating stack: `+i.message+`
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315
  * react-table
291
316
  *
292
317
  * Copyright (c) TanStack
@@ -295,4 +320,4 @@ Error generating stack: `+i.message+`
295
320
  * LICENSE.md file in the root directory of this source tree.
296
321
  *
297
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  * @license MIT
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C=y>0?this.getVirtualItemForOffset(this.getScrollOffset())??j[0]:null;C&&(h=[C.key,this.getScrollOffset()-C.start]);const E=c.followOnAppend===!0?"auto":c.followOnAppend||null;E&&S>0&&this.isAtEnd(d.scrollEndThreshold)&&(y===0||c.getItemKey(S-1)!==O)&&(S>y||hT(y,S,N,c.getItemKey))&&(m=E)}}this.options=c,g&&(this.pendingMin=0,this.itemSizeCacheVersion++);let x=!1,v=0;if(h&&this.scrollOffset!==null){const[y,S]=h,j=this.getMeasurements(),{count:b,getItemKey:N}=this.options;let T=0;for(;T<b&&N(T)!==y;)T++;if(T<b){const O=j[T];if(O){const _=Math.max(0,O.start+S);!m&&_!==this.scrollOffset&&(v=_-this.scrollOffset,this.scrollOffset=_,x=!0)}}}(x||m)&&(this.pendingScrollAnchor=[x?h[0]:null,x?h[1]:0,m,v])},this.notify=a=>{var o,c;(c=(o=this.options).onChange)==null||c.call(o,this,a)},this.maybeNotify=Li(()=>(this.calculateRange(),[this.isScrolling,this.range?this.range.startIndex:null,this.range?this.range.endIndex:null]),a=>{this.notify(a)},{key:!1,debug:()=>this.options.debug,initialDeps:[this.isScrolling,this.range?this.range.startIndex:null,this.range?this.range.endIndex:null]}),this.cleanup=()=>{this.unsubs.filter(Boolean).forEach(a=>a()),this.unsubs=[],this.observer.disconnect(),this.rafId!=null&&this.targetWindow&&(this.targetWindow.cancelAnimationFrame(this.rafId),this.rafId=null),this.scrollState=null,this.isScrolling=!1,this.scrollDirection=null,this._iosDeferredAdjustment=0,this._iosTouching=!1,this._iosJustTouchEnded=!1,this._clampedAdjustment=null,this.scrollElement=null,this.targetWindow=null},this._didMount=()=>()=>{this.cleanup()},this._willUpdate=()=>{var a,o;const c=this.options.enabled?this.options.getScrollElement():null;if(this.scrollElement!==c){if(this.cleanup(),!c){this.maybeNotify();return}if(this.scrollElement=c,this.scrollElement&&"ownerDocument"in this.scrollElement?this.targetWindow=this.scrollElement.ownerDocument.defaultView:this.targetWindow=((a=this.scrollElement)==null?void 0:a.window)??null,this.elementsCache.forEach(h=>{this.observer.observe(h)}),this.unsubs.push(this.options.observeElementRect(this,h=>{this.scrollRect=h,this.maybeNotify()})),this.unsubs.push(this.options.observeElementOffset(this,(h,m)=>{if(m&&this._intendedScrollOffset===null&&h===this.scrollOffset)return;this._intendedScrollOffset!==null&&Math.abs(h-this._intendedScrollOffset)<1.5&&(h=this._intendedScrollOffset),this._intendedScrollOffset=null,this._clampedAdjustment!==null&&Math.abs(h-this._clampedAdjustment.maxAtWrite)>=1.5&&(this._clampedAdjustment=null),this.scrollAdjustments=0;const g=this.getScrollOffset();this.scrollDirection=m?g===h?this.scrollDirection:g<h?"forward":"backward":null,this.scrollOffset=h,this.isScrolling=m,this._flushIosDeferredIfReady(),this.scrollState&&this.scheduleScrollReconcile(),this.maybeNotify()})),"addEventListener"in this.scrollElement){const h=this.scrollElement,m=()=>{this._iosTouching=!0,this._iosJustTouchEnded=!1,this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)},g=()=>{this._iosTouching=!1,!(!em()||this.targetWindow==null)&&(this._iosJustTouchEnded=!0,this._iosTouchEndTimerId=this.targetWindow.setTimeout(()=>{this._iosJustTouchEnded=!1,this._iosTouchEndTimerId=null,this._flushIosDeferredIfReady()},150))};h.addEventListener("touchstart",m,ku),h.addEventListener("touchend",g,ku),this.unsubs.push(()=>{h.removeEventListener("touchstart",m),h.removeEventListener("touchend",g),this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)})}this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})}const d=this.pendingScrollAnchor;if(this.pendingScrollAnchor=null,d&&this.scrollElement&&this.options.enabled){const[h,m,g,x]=d;h!==null&&!g&&(em()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded)?x!==0&&(this._iosDeferredAdjustment+=x):((o=this.scrollState)==null?void 0:o.behavior)==="smooth"&&!$x(this.getScrollOffset()-x,this.scrollState.lastTargetOffset)||this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})),g&&this.scrollToEnd({behavior:g})}this._retryClampedAdjustment()},this._retryClampedAdjustment=()=>{if(this._clampedAdjustment===null||!this.scrollElement||!this.options.enabled)return;const{target:a,maxAtWrite:o}=this._clampedAdjustment,c=this.getMaxScrollOffset();c>o+.5&&(this._clampedAdjustment=a>c+.5?{target:a,maxAtWrite:c}:null,this._scrollToOffset(a,{adjustments:void 0,behavior:void 0}))},this._flushIosDeferredIfReady=()=>{if(this._iosDeferredAdjustment===0||this.isScrolling||this._iosTouching||this._iosJustTouchEnded)return;const a=this.getScrollOffset(),o=this.getMaxScrollOffset();if(a<0||a>o)return;if(this._iosDeferredAdjustment<0&&a>=o-1){this._iosDeferredAdjustment=0;return}const c=this._iosDeferredAdjustment;this._iosDeferredAdjustment=0,this._scrollToOffset(a,{adjustments:this.scrollAdjustments+=c,behavior:void 0})},this.rafId=null,this.getSize=()=>this.options.enabled?(this.scrollRect=this.scrollRect??this.options.initialRect,this.scrollRect[this.options.horizontal?"width":"height"]):(this.scrollRect=null,0),this.getScrollOffset=()=>this.options.enabled?(this.scrollOffset=this.scrollOffset??(typeof this.options.initialOffset=="function"?this.options.initialOffset():this.options.initialOffset),this.scrollOffset):(this.scrollOffset=null,0),this.getMeasurementOptions=Li(()=>[this.options.count,this.options.paddingStart,this.options.scrollMargin,this.options.getItemKey,this.options.enabled,this.options.lanes,this.options.laneAssignmentMode,this.options.gap],(a,o,c,d,h,m,g,x)=>(this.prevLanes!==void 0&&this.prevLanes!==m&&(this.lanesChangedFlag=!0),this.prevLanes=m,this.pendingMin=null,{count:a,paddingStart:o,scrollMargin:c,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:g,gap:x}),{key:!1}),this.isIndexInRange=a=>a>=0&&a<this.options.count,this.getMeasurements=Li(()=>[this.getMeasurementOptions(),this.itemSizeCacheVersion],({count:a,paddingStart:o,scrollMargin:c,getItemKey:d,enabled:h,lanes:m,laneAssignmentMode:g,gap:x},v)=>{var y;const S=this.itemSizeCache;if(!h)return this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),[];if(this.laneAssignments.size>a)for(const _ of this.laneAssignments.keys())_>=a&&this.laneAssignments.delete(_);this.lanesChangedFlag&&(this.lanesChangedFlag=!1,this.lanesSettling=!0,this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.pendingMin=null),this.measurementsCache.length===0&&!this.lanesSettling&&(this.measurementsCache=this.options.initialMeasurementsCache,this.measurementsCache.forEach(_=>{this.itemSizeCache.set(_.key,_.size)}));const j=this.lanesSettling?0:this.pendingMin??0;if(this.pendingMin=null,this.lanesSettling&&this.measurementsCache.length===a&&(this.lanesSettling=!1),m===1){const _=a*2;let D=(y=this._singleLaneMeasurements)==null?void 0:y.flat;if(!D||D.length<_){const A=new Float64Array(_);D&&j>0&&A.set(D.subarray(0,j*2)),D=A}const C=j===0?new Array(a):this._singleLaneMeasurements.items.slice();let E;if(j===0)E=o+c;else{const A=j-1;E=D[A*2]+D[A*2+1]+x}for(let A=j;A<a;A++){const B=d(A);C[A]=B;const K=S.get(B),k=typeof K=="number"?K:this.options.estimateSize(A);D[A*2]=E,D[A*2+1]=k,E+=k+x}this._singleLaneMeasurements={flat:D,items:C};const R=nT(C,D);return this.measurementsCache=R,R}const b=this.measurementsCache.slice(0,j),N=new Array(m).fill(void 0),T=new Float64Array(m);let O=0;for(let _=0;_<j;_++){const D=b[_];D&&(N[D.lane]===void 0&&O++,N[D.lane]=_,T[D.lane]=D.end)}for(let _=j;_<a;_++){const D=d(_),C=this.laneAssignments.get(_);let E,R;const A=g==="estimate"||S.has(D);if(C!==void 0&&this.options.lanes>1){E=C;const ie=N[E],oe=ie!==void 0?b[ie]:void 0;R=oe?oe.end+x:o+c}else if(O===m){let ie=0,oe=T[0],se=N[0];for(let P=1;P<m;P++){const le=T[P];(le<oe||le===oe&&N[P]<se)&&(ie=P,oe=le,se=N[P])}E=ie,R=oe+x,A&&this.laneAssignments.set(_,E)}else E=_%this.options.lanes,R=o+c,A&&this.laneAssignments.set(_,E);const B=S.get(D),K=typeof B=="number"?B:this.options.estimateSize(_),k=R+K;b[_]={index:_,start:R,size:K,end:k,key:D,lane:E},N[E]===void 0&&O++,N[E]=_,T[E]=k}return this.measurementsCache=b,b},{key:!1,debug:()=>this.options.debug}),this.calculateRange=Li(()=>[this.getMeasurements(),this.getSize(),this.getScrollOffset(),this.options.lanes],(a,o,c,d)=>a.length===0||o===0?(this.range=null,null):(this.range=pT(a,o,c,d,d===1&&this._singleLaneMeasurements!==null?this._singleLaneMeasurements.flat:null),this.range),{key:!1,debug:()=>this.options.debug}),this.getVirtualIndexes=Li(()=>{let a=null,o=null;const c=this.calculateRange();return c&&(a=c.startIndex,o=c.endIndex),this.maybeNotify.updateDeps([this.isScrolling,a,o]),[this.options.rangeExtractor,this.options.overscan,this.options.count,a,o]},(a,o,c,d,h)=>d===null||h===null?[]:a({startIndex:d,endIndex:h,overscan:o,count:c}),{key:!1,debug:()=>this.options.debug}),this.indexFromElement=a=>{const o=this.options.indexAttribute,c=a.getAttribute(o);return c?parseInt(c,10):(console.warn(`Missing attribute name '${o}={index}' on measured element.`),-1)},this.shouldMeasureDuringScroll=a=>{var o;if(!this.scrollState||this.scrollState.behavior!=="smooth")return!0;const c=this.scrollState.index??((o=this.getVirtualItemForOffset(this.scrollState.lastTargetOffset))==null?void 0:o.index);if(c!==void 0&&this.range){const d=Math.max(this.options.overscan,Math.ceil((this.range.endIndex-this.range.startIndex)/2)),h=Math.max(0,c-d),m=Math.min(this.options.count-1,c+d);return a>=h&&a<=m}return!0},this.measureElement=a=>{if(!a){this.elementsCache.forEach((h,m)=>{h.isConnected||(this.observer.unobserve(h),this.elementsCache.delete(m))});return}const o=this.indexFromElement(a);if(!this.isIndexInRange(o))return;const c=this.options.getItemKey(o),d=this.elementsCache.get(c);d!==a&&(d&&this.observer.unobserve(d),this.observer.observe(a),this.elementsCache.set(c,a)),(!this.isScrolling||this.scrollState)&&this.shouldMeasureDuringScroll(o)&&this.resizeItem(o,this.options.measureElement(a,void 0,this))},this.resizeItem=(a,o)=>{var c,d,h;if(!this.isIndexInRange(a))return;let m,g,x;const v=(c=this._singleLaneMeasurements)==null?void 0:c.flat;if(this.options.lanes===1&&v!=null)x=this.options.getItemKey(a),g=v[a*2],m=v[a*2+1];else{const j=this.measurementsCache[a];if(!j)return;x=j.key,g=j.start,m=j.size}const y=this.itemSizeCache.get(x)??m,S=o-y;if(S!==0){const j=this.options.anchorTo==="end"&&((d=this.scrollState)==null?void 0:d.behavior)!=="smooth"&&this.getVirtualDistanceFromEnd()<=this.options.scrollEndThreshold,b=j?this.getTotalSize():0,N=this.getScrollOffset()+this.scrollAdjustments,O=!this.itemSizeCache.has(x)?g<N:g+y<=N&&this.scrollDirection!=="backward",_=((h=this.scrollState)==null?void 0:h.behavior)!=="smooth"&&(this.shouldAdjustScrollPositionOnItemSizeChange!==void 0?this.shouldAdjustScrollPositionOnItemSizeChange(this.measurementsCache[a]??{index:a,key:x,start:g,size:m,end:g+m,lane:0},S,this):O);(this.pendingMin===null||a<this.pendingMin)&&(this.pendingMin=a),this.itemSizeCache.set(x,o),this.itemSizeCacheVersion++;let D=!1;j?D=this.applyScrollAdjustment(this.getTotalSize()-b):_&&(D=this.applyScrollAdjustment(S)),this.notify(D),this._retryClampedAdjustment()}},this.getVirtualItems=Li(()=>[this.getVirtualIndexes(),this.getMeasurements()],(a,o)=>{const c=[];for(let d=0,h=a.length;d<h;d++){const m=a[d],g=o[m];c.push(g)}return c},{key:!1,debug:()=>this.options.debug}),this.getVirtualItemForOffset=a=>{var o;const c=this.getMeasurements();if(c.length===0)return;const d=(o=this._singleLaneMeasurements)==null?void 0:o.flat,h=this.options.lanes===1&&d!=null,m=AS(0,c.length-1,h?g=>d[g*2]:g=>Lx(c[g]).start,a);return Lx(c[m])},this.getMaxScrollOffset=()=>{if(!this.scrollElement)return 0;if("scrollHeight"in this.scrollElement)return this.options.horizontal?this.scrollElement.scrollWidth-this.scrollElement.clientWidth:this.scrollElement.scrollHeight-this.scrollElement.clientHeight;{const a=this.scrollElement.document.documentElement;return this.options.horizontal?a.scrollWidth-this.scrollElement.innerWidth:a.scrollHeight-this.scrollElement.innerHeight}},this.getVirtualDistanceFromEnd=()=>Math.max(this.getTotalSize()-this.getSize()-this.getScrollOffset(),0),this.getDistanceFromEnd=()=>Math.max(this.getMaxScrollOffset()-this.getScrollOffset(),0),this.isAtEnd=(a=this.options.scrollEndThreshold)=>this.getDistanceFromEnd()<=a,this.getOffsetForAlignment=(a,o,c=0)=>{if(!this.scrollElement)return 0;const d=this.getSize(),h=this.getScrollOffset();o==="auto"&&(o=a>=h+d?"end":"start"),o==="center"?a+=(c-d)/2:o==="end"&&(a-=d);const m=this.getMaxScrollOffset();return Math.max(Math.min(m,a),0)},this.getOffsetForIndex=(a,o="auto")=>{a=Math.max(0,Math.min(a,this.options.count-1));const c=this.getSize(),d=this.getScrollOffset(),h=this.measurementsCache[a];if(!h)return;if(o==="auto")if(h.end>=d+c-this.options.scrollPaddingEnd)o="end";else if(h.start<=d+this.options.scrollPaddingStart)o="start";else return[d,o];if(o==="end"&&a===this.options.count-1)return[this.getMaxScrollOffset(),o];const m=o==="end"?h.end+this.options.scrollPaddingEnd:h.start-this.options.scrollPaddingStart;return[this.getOffsetForAlignment(m,o,h.size),o]},this.scrollToOffset=(a,{align:o="start",behavior:c="auto"}={})=>{this._iosDeferredAdjustment=0;const d=this.getOffsetForAlignment(a,o),h=this.now();this.scrollState={index:null,align:o,behavior:c,startedAt:h,lastTargetOffset:d,stableFrames:0},this._scrollToOffset(d,{adjustments:void 0,behavior:c}),this.scheduleScrollReconcile()},this.scrollToIndex=(a,{align:o="auto",behavior:c="auto"}={})=>{this._iosDeferredAdjustment=0,a=Math.max(0,Math.min(a,this.options.count-1));const d=this.getOffsetForIndex(a,o);if(!d)return;const[h,m]=d,g=this.now();this.scrollState={index:a,align:m,behavior:c,startedAt:g,lastTargetOffset:h,stableFrames:0},this._scrollToOffset(h,{adjustments:void 0,behavior:c}),this.scheduleScrollReconcile()},this.scrollBy=(a,{behavior:o="auto"}={})=>{const c=this.getScrollOffset()+a,d=this.now();this.scrollState={index:null,align:"start",behavior:o,startedAt:d,lastTargetOffset:c,stableFrames:0},this._scrollToOffset(c,{adjustments:void 0,behavior:o}),this.scheduleScrollReconcile()},this.scrollToEnd=({behavior:a="auto"}={})=>{if(this.options.count>0){this.scrollToIndex(this.options.count-1,{align:"end",behavior:a});return}this.scrollToOffset(Math.max(this.getTotalSize()-this.getSize(),0),{behavior:a})},this.getTotalSize=()=>{var a,o;const c=this.getMeasurements();let d;if(c.length===0)d=this.options.paddingStart;else if(this.options.lanes===1){const h=c.length-1,m=(a=this._singleLaneMeasurements)==null?void 0:a.flat;m!=null?d=m[h*2]+m[h*2+1]:d=((o=c[h])==null?void 0:o.end)??0}else{const h=Array(this.options.lanes).fill(null);let m=c.length-1;for(;m>=0&&h.some(g=>g===null);){const g=c[m];h[g.lane]===null&&(h[g.lane]=g.end),m--}d=Math.max(...h.filter(g=>g!==null))}return Math.max(d-this.options.scrollMargin+this.options.paddingEnd,0)},this.takeSnapshot=()=>{const a=[];if(this.itemSizeCache.size===0)return a;const o=this.getMeasurements();for(const c of o)c&&this.itemSizeCache.has(c.key)&&a.push({index:c.index,key:c.key,start:c.start,size:c.size,end:c.end,lane:c.lane});return a},this._scrollToOffset=(a,{adjustments:o,behavior:c})=>{this._intendedScrollOffset=a+(o??0),this.options.scrollToFn(a,{behavior:c,adjustments:o},this)},this.measure=()=>{this.pendingMin=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.itemSizeCacheVersion++,this.notify(!1)},this.setOptions(l)}applyScrollAdjustment(l,a){if(l===0)return!1;if(em()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded))return this._iosDeferredAdjustment+=l,!1;{const o=this.getScrollOffset()+this.scrollAdjustments+l,c=this.scrollElement,d=c!==null&&("scrollHeight"in c||"document"in c)?this.getMaxScrollOffset():null;return this._clampedAdjustment=d!==null&&o>d+.5?{target:o,maxAtWrite:d}:null,this._scrollToOffset(this.getScrollOffset(),{adjustments:this.scrollAdjustments+=l,behavior:a}),this.scrollOffset!==null&&(this.scrollOffset+=this.scrollAdjustments,this.scrollOffset<0&&(this.scrollOffset=0),this.scrollAdjustments=0),!0}}scheduleScrollReconcile(){if(!this.targetWindow){this.scrollState=null;return}this.rafId==null&&(this.rafId=this.targetWindow.requestAnimationFrame(()=>{this.rafId=null,this.reconcileScroll()}))}reconcileScroll(){if(!this.scrollState||!this.scrollElement)return;if(this.now()-this.scrollState.startedAt>5e3){this.scrollState=null;return}const o=this.scrollState.index!=null?this.getOffsetForIndex(this.scrollState.index,this.scrollState.align):void 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i=l.indexFromElement(n),c=l.options.getItemKey(i);return l.itemSizeCache.get(c)??l.options.estimateSize(i)}if(a!=null&&a.borderBoxSize){const i=a.borderBoxSize[0];if(i)return Math.round(i[l.options.horizontal?"inlineSize":"blockSize"])}if(!a){const i=l.indexFromElement(n),c=l.options.getItemKey(i),d=l.itemSizeCache.get(c);if(d!==void 0)return d}return n[l.options.horizontal?"offsetWidth":"offsetHeight"]},o4=(n,{adjustments:a=0,behavior:l},i)=>{var c,d;(d=(c=i.scrollElement)==null?void 0:c.scrollTo)==null||d.call(c,{[i.options.horizontal?"left":"top"]:n+a,behavior:l})},r4=o4;function c4(n,a,l,i){if(a===0)return!1;const c=i(0),d=new Set;let f=0;for(;f<n;){const g=l(f);if(g===c)break;d.add(g),f++}const m=n-f;if(m===0||m>=a)return!1;for(let g=0;g<m;g++)if(i(g)!==l(f+g))return!1;for(let g=m;g<a;g++)if(d.has(i(g)))return!1;return!0}class u4{constructor(a){this.unsubs=[],this.scrollElement=null,this.targetWindow=null,this.isScrolling=!1,this.scrollState=null,this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache=new Map,this.itemSizeCacheVersion=0,this.laneAssignments=new Map,this.pendingMin=null,this.prevLanes=void 0,this.lanesChangedFlag=!1,this.lanesSettling=!1,this.pendingScrollAnchor=null,this.scrollRect=null,this.scrollOffset=null,this.scrollDirection=null,this.scrollAdjustments=0,this._iosDeferredAdjustment=0,this._iosTouching=!1,this._iosJustTouchEnded=!1,this._iosTouchEndTimerId=null,this._intendedScrollOffset=null,this._clampedAdjustment=null,this.elementsCache=new Map,this.now=()=>{var l,i,c;return((c=(i=(l=this.targetWindow)==null?void 0:l.performance)==null?void 0:i.now)==null?void 0:c.call(i))??Date.now()},this.observer=(()=>{let l=null;const i=()=>l||(!this.targetWindow||!this.targetWindow.ResizeObserver?null:l=new this.targetWindow.ResizeObserver(c=>{c.forEach(d=>{const f=()=>{const m=d.target,g=this.indexFromElement(m);if(!m.isConnected){this.observer.unobserve(m);for(const[v,x]of this.elementsCache)if(x===m){this.elementsCache.delete(v);break}return}this.isIndexInRange(g)&&this.shouldMeasureDuringScroll(g)&&this.resizeItem(g,this.options.measureElement(m,d,this))};this.options.useAnimationFrameWithResizeObserver?requestAnimationFrame(f):f()})}));return{disconnect:()=>{var c;(c=i())==null||c.disconnect(),l=null},observe:c=>{var d;return(d=i())==null?void 0:d.observe(c,{box:"border-box"})},unobserve:c=>{var d;return(d=i())==null?void 0:d.unobserve(c)}}})(),this.range=null,this.setOptions=l=>{var i;const c={debug:!1,initialOffset:0,overscan:1,paddingStart:0,paddingEnd:0,scrollPaddingStart:0,scrollPaddingEnd:0,horizontal:!1,getItemKey:e4,rangeExtractor:t4,onChange:()=>{},measureElement:i4,initialRect:{width:0,height:0},scrollMargin:0,gap:0,indexAttribute:"data-index",initialMeasurementsCache:[],lanes:1,anchorTo:"start",followOnAppend:!1,scrollEndThreshold:1,isScrollingResetDelay:150,enabled:!0,isRtl:!1,useScrollendEvent:!1,useAnimationFrameWithResizeObserver:!1,laneAssignmentMode:"estimate",useCachedMeasurements:!1};for(const p in l){const b=l[p];b!==void 0&&(c[p]=b)}const d=this.options;let f=null,m=null,g=!1;if(d!==void 0&&d.enabled&&c.enabled&&c.anchorTo==="end"&&this.scrollElement!==null){const p=d.count,b=c.count,S=this.getMeasurements(),j=((i=this._singleLaneMeasurements)==null?void 0:i.items)??S,N=M=>ZE(j[M]),R=p>0?N(0):null,A=p>0?N(p-1):null;if(b!==p||p>0&&b>0&&(c.getItemKey(0)!==R||c.getItemKey(b-1)!==A)){g=!0;const M=p>0?this.getVirtualItemForOffset(this.getScrollOffset())??S[0]:null;M&&(f=[M.key,this.getScrollOffset()-M.start]);const E=c.followOnAppend===!0?"auto":c.followOnAppend||null;E&&b>0&&this.isAtEnd(d.scrollEndThreshold)&&(p===0||c.getItemKey(b-1)!==A)&&(b>p||c4(p,b,N,c.getItemKey))&&(m=E)}}this.options=c,g&&(this.pendingMin=0,this.itemSizeCacheVersion++);let v=!1,x=0;if(f&&this.scrollOffset!==null){const[p,b]=f,S=this.getMeasurements(),{count:j,getItemKey:N}=this.options;let R=0;for(;R<j&&N(R)!==p;)R++;if(R<j){const A=S[R];if(A){const T=Math.max(0,A.start+b);!m&&T!==this.scrollOffset&&(x=T-this.scrollOffset,this.scrollOffset=T,v=!0)}}}(v||m)&&(this.pendingScrollAnchor=[v?f[0]:null,v?f[1]:0,m,x])},this.notify=l=>{var i,c;(c=(i=this.options).onChange)==null||c.call(i,this,l)},this.maybeNotify=qi(()=>(this.calculateRange(),[this.isScrolling,this.range?this.range.startIndex:null,this.range?this.range.endIndex:null]),l=>{this.notify(l)},{key:!1,debug:()=>this.options.debug,initialDeps:[this.isScrolling,this.range?this.range.startIndex:null,this.range?this.range.endIndex:null]}),this.cleanup=()=>{this.unsubs.filter(Boolean).forEach(l=>l()),this.unsubs=[],this.observer.disconnect(),this.rafId!=null&&this.targetWindow&&(this.targetWindow.cancelAnimationFrame(this.rafId),this.rafId=null),this.scrollState=null,this.isScrolling=!1,this.scrollDirection=null,this._iosDeferredAdjustment=0,this._iosTouching=!1,this._iosJustTouchEnded=!1,this._clampedAdjustment=null,this.scrollElement=null,this.targetWindow=null},this._didMount=()=>()=>{this.cleanup()},this._willUpdate=()=>{var l,i;const c=this.options.enabled?this.options.getScrollElement():null;if(this.scrollElement!==c){if(this.cleanup(),!c){this.maybeNotify();return}if(this.scrollElement=c,this.scrollElement&&"ownerDocument"in this.scrollElement?this.targetWindow=this.scrollElement.ownerDocument.defaultView:this.targetWindow=((l=this.scrollElement)==null?void 0:l.window)??null,this.elementsCache.forEach(f=>{this.observer.observe(f)}),this.unsubs.push(this.options.observeElementRect(this,f=>{this.scrollRect=f,this.maybeNotify()})),this.unsubs.push(this.options.observeElementOffset(this,(f,m)=>{if(m&&this._intendedScrollOffset===null&&f===this.scrollOffset)return;this._intendedScrollOffset!==null&&Math.abs(f-this._intendedScrollOffset)<1.5&&(f=this._intendedScrollOffset),this._intendedScrollOffset=null,this._clampedAdjustment!==null&&Math.abs(f-this._clampedAdjustment.maxAtWrite)>=1.5&&(this._clampedAdjustment=null),this.scrollAdjustments=0;const g=this.getScrollOffset();this.scrollDirection=m?g===f?this.scrollDirection:g<f?"forward":"backward":null,this.scrollOffset=f,this.isScrolling=m,this._flushIosDeferredIfReady(),this.scrollState&&this.scheduleScrollReconcile(),this.maybeNotify()})),"addEventListener"in this.scrollElement){const f=this.scrollElement,m=()=>{this._iosTouching=!0,this._iosJustTouchEnded=!1,this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)},g=()=>{this._iosTouching=!1,!(!xm()||this.targetWindow==null)&&(this._iosJustTouchEnded=!0,this._iosTouchEndTimerId=this.targetWindow.setTimeout(()=>{this._iosJustTouchEnded=!1,this._iosTouchEndTimerId=null,this._flushIosDeferredIfReady()},150))};f.addEventListener("touchstart",m,Ju),f.addEventListener("touchend",g,Ju),this.unsubs.push(()=>{f.removeEventListener("touchstart",m),f.removeEventListener("touchend",g),this._iosTouchEndTimerId!==null&&this.targetWindow!=null&&(this.targetWindow.clearTimeout(this._iosTouchEndTimerId),this._iosTouchEndTimerId=null)})}this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})}const d=this.pendingScrollAnchor;if(this.pendingScrollAnchor=null,d&&this.scrollElement&&this.options.enabled){const[f,m,g,v]=d;f!==null&&!g&&(xm()&&(this.isScrolling||this._iosTouching||this._iosJustTouchEnded)?v!==0&&(this._iosDeferredAdjustment+=v):((i=this.scrollState)==null?void 0:i.behavior)==="smooth"&&!Wv(this.getScrollOffset()-v,this.scrollState.lastTargetOffset)||this._scrollToOffset(this.getScrollOffset(),{adjustments:void 0,behavior:void 0})),g&&this.scrollToEnd({behavior:g})}this._retryClampedAdjustment()},this._retryClampedAdjustment=()=>{if(this._clampedAdjustment===null||!this.scrollElement||!this.options.enabled)return;const{target:l,maxAtWrite:i}=this._clampedAdjustment,c=this.getMaxScrollOffset();c>i+.5&&(this._clampedAdjustment=l>c+.5?{target:l,maxAtWrite:c}:null,this._scrollToOffset(l,{adjustments:void 0,behavior:void 0}))},this._flushIosDeferredIfReady=()=>{if(this._iosDeferredAdjustment===0||this.isScrolling||this._iosTouching||this._iosJustTouchEnded)return;const l=this.getScrollOffset(),i=this.getMaxScrollOffset();if(l<0||l>i)return;if(this._iosDeferredAdjustment<0&&l>=i-1){this._iosDeferredAdjustment=0;return}const c=this._iosDeferredAdjustment;this._iosDeferredAdjustment=0,this._scrollToOffset(l,{adjustments:this.scrollAdjustments+=c,behavior:void 0})},this.rafId=null,this.getSize=()=>this.options.enabled?(this.scrollRect=this.scrollRect??this.options.initialRect,this.scrollRect[this.options.horizontal?"width":"height"]):(this.scrollRect=null,0),this.getScrollOffset=()=>this.options.enabled?(this.scrollOffset=this.scrollOffset??(typeof this.options.initialOffset=="function"?this.options.initialOffset():this.options.initialOffset),this.scrollOffset):(this.scrollOffset=null,0),this.getMeasurementOptions=qi(()=>[this.options.count,this.options.paddingStart,this.options.scrollMargin,this.options.getItemKey,this.options.enabled,this.options.lanes,this.options.laneAssignmentMode,this.options.gap],(l,i,c,d,f,m,g,v)=>(this.prevLanes!==void 0&&this.prevLanes!==m&&(this.lanesChangedFlag=!0),this.prevLanes=m,this.pendingMin=null,{count:l,paddingStart:i,scrollMargin:c,getItemKey:d,enabled:f,lanes:m,laneAssignmentMode:g,gap:v}),{key:!1}),this.isIndexInRange=l=>l>=0&&l<this.options.count,this.getMeasurements=qi(()=>[this.getMeasurementOptions(),this.itemSizeCacheVersion],({count:l,paddingStart:i,scrollMargin:c,getItemKey:d,enabled:f,lanes:m,laneAssignmentMode:g,gap:v},x)=>{var p;const b=this.itemSizeCache;if(!f)return this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),[];if(this.laneAssignments.size>l)for(const T of this.laneAssignments.keys())T>=l&&this.laneAssignments.delete(T);this.lanesChangedFlag&&(this.lanesChangedFlag=!1,this.lanesSettling=!0,this.measurementsCache=[],this._singleLaneMeasurements=null,this.itemSizeCache.clear(),this.laneAssignments.clear(),this.pendingMin=null),this.measurementsCache.length===0&&!this.lanesSettling&&(this.measurementsCache=this.options.initialMeasurementsCache,this.measurementsCache.forEach(T=>{this.itemSizeCache.set(T.key,T.size)}));const S=this.lanesSettling?0:this.pendingMin??0;if(this.pendingMin=null,this.lanesSettling&&this.measurementsCache.length===l&&(this.lanesSettling=!1),m===1){const T=l*2;let O=(p=this._singleLaneMeasurements)==null?void 0:p.flat;if(!O||O.length<T){const D=new Float64Array(T);O&&S>0&&D.set(O.subarray(0,S*2)),O=D}const M=S===0?new Array(l):this._singleLaneMeasurements.items.slice();let E;if(S===0)E=i+c;else{const D=S-1;E=O[D*2]+O[D*2+1]+v}for(let D=S;D<l;D++){const P=d(D);M[D]=P;const Z=b.get(P),z=typeof Z=="number"?Z:this.options.estimateSize(D);O[D*2]=E,O[D*2+1]=z,E+=z+v}this._singleLaneMeasurements={flat:O,items:M};const _=JE(M,O);return this.measurementsCache=_,_}const j=this.measurementsCache.slice(0,S),N=new Array(m).fill(void 0),R=new Float64Array(m);let A=0;for(let T=0;T<S;T++){const O=j[T];O&&(N[O.lane]===void 0&&A++,N[O.lane]=T,R[O.lane]=O.end)}for(let T=S;T<l;T++){const O=d(T),M=this.laneAssignments.get(T);let E,_;const D=g==="estimate"||b.has(O);if(M!==void 0&&this.options.lanes>1){E=M;const te=N[E],ie=te!==void 0?j[te]:void 0;_=ie?ie.end+v:i+c}else if(A===m){let te=0,ie=R[0],J=N[0];for(let se=1;se<m;se++){const re=R[se];(re<ie||re===ie&&N[se]<J)&&(te=se,ie=re,J=N[se])}E=te,_=ie+v,D&&this.laneAssignments.set(T,E)}else E=T%this.options.lanes,_=i+c,D&&this.laneAssignments.set(T,E);const P=b.get(O),Z=typeof P=="number"?P:this.options.estimateSize(T),z=_+Z;j[T]={index:T,start:_,size:Z,end:z,key:O,lane:E},N[E]===void 0&&A++,N[E]=T,R[E]=z}return this.measurementsCache=j,j},{key:!1,debug:()=>this.options.debug}),this.calculateRange=qi(()=>[this.getMeasurements(),this.getSize(),this.getScrollOffset(),this.options.lanes],(l,i,c,d)=>l.length===0||i===0?(this.range=null,null):(this.range=h4(l,i,c,d,d===1&&this._singleLaneMeasurements!==null?this._singleLaneMeasurements.flat:null),this.range),{key:!1,debug:()=>this.options.debug}),this.getVirtualIndexes=qi(()=>{let l=null,i=null;const c=this.calculateRange();return c&&(l=c.startIndex,i=c.endIndex),this.maybeNotify.updateDeps([this.isScrolling,l,i]),[this.options.rangeExtractor,this.options.overscan,this.options.count,l,i]},(l,i,c,d,f)=>d===null||f===null?[]:l({startIndex:d,endIndex:f,overscan:i,count:c}),{key:!1,debug:()=>this.options.debug}),this.indexFromElement=l=>{const i=this.options.indexAttribute,c=l.getAttribute(i);return c?parseInt(c,10):(console.warn(`Missing attribute name '${i}={index}' on measured element.`),-1)},this.shouldMeasureDuringScroll=l=>{var i;if(!this.scrollState||this.scrollState.behavior!=="smooth")return!0;const c=this.scrollState.index??((i=this.getVirtualItemForOffset(this.scrollState.lastTargetOffset))==null?void 0:i.index);if(c!==void 0&&this.range){const d=Math.max(this.options.overscan,Math.ceil((this.range.endIndex-this.range.startIndex)/2)),f=Math.max(0,c-d),m=Math.min(this.options.count-1,c+d);return l>=f&&l<=m}return!0},this.measureElement=l=>{if(!l){this.elementsCache.forEach((f,m)=>{f.isConnected||(this.observer.unobserve(f),this.elementsCache.delete(m))});return}const i=this.indexFromElement(l);if(!this.isIndexInRange(i))return;const c=this.options.getItemKey(i),d=this.elementsCache.get(c);d!==l&&(d&&this.observer.unobserve(d),this.observer.observe(l),this.elementsCache.set(c,l)),(!this.isScrolling||this.scrollState)&&this.shouldMeasureDuringScroll(i)&&this.resizeItem(i,this.options.measureElement(l,void 0,this))},this.resizeItem=(l,i)=>{var c,d,f;if(!this.isIndexInRange(l))return;let m,g,v;const x=(c=this._singleLaneMeasurements)==null?void 0:c.flat;if(this.options.lanes===1&&x!=null)v=this.options.getItemKey(l),g=x[l*2],m=x[l*2+1];else{const S=this.measurementsCache[l];if(!S)return;v=S.key,g=S.start,m=S.size}const p=this.itemSizeCache.get(v)??m,b=i-p;if(b!==0){const S=this.options.anchorTo==="end"&&((d=this.scrollState)==null?void 0:d.behavior)!=="smooth"&&this.getVirtualDistanceFromEnd()<=this.options.scrollEndThreshold,j=S?this.getTotalSize():0,N=this.getScrollOffset()+this.scrollAdjustments,A=!this.itemSizeCache.has(v)?g<N:g+p<=N&&this.scrollDirection!=="backward",T=((f=this.scrollState)==null?void 0:f.behavior)!=="smooth"&&(this.shouldAdjustScrollPositionOnItemSizeChange!==void 0?this.shouldAdjustScrollPositionOnItemSizeChange(this.measurementsCache[l]??{index:l,key:v,start:g,size:m,end:g+m,lane:0},b,this):A);(this.pendingMin===null||l<this.pendingMin)&&(this.pendingMin=l),this.itemSizeCache.set(v,i),this.itemSizeCacheVersion++;let O=!1;S?O=this.applyScrollAdjustment(this.getTotalSize()-j):T&&(O=this.applyScrollAdjustment(b)),this.notify(O),this._retryClampedAdjustment()}},this.getVirtualItems=qi(()=>[this.getVirtualIndexes(),this.getMeasurements()],(l,i)=>{const c=[];for(let d=0,f=l.length;d<f;d++){const m=l[d],g=i[m];c.push(g)}return c},{key:!1,debug:()=>this.options.debug}),this.getVirtualItemForOffset=l=>{var i;const c=this.getMeasurements();if(c.length===0)return;const d=(i=this._singleLaneMeasurements)==null?void 0:i.flat,f=this.options.lanes===1&&d!=null,m=rb(0,c.length-1,f?g=>d[g*2]:g=>Jv(c[g]).start,l);return Jv(c[m])},this.getMaxScrollOffset=()=>{if(!this.scrollElement)return 0;if("scrollHeight"in this.scrollElement)return this.options.horizontal?this.scrollElement.scrollWidth-this.scrollElement.clientWidth:this.scrollElement.scrollHeight-this.scrollElement.clientHeight;{const l=this.scrollElement.document.documentElement;return this.options.horizontal?l.scrollWidth-this.scrollElement.innerWidth:l.scrollHeight-this.scrollElement.innerHeight}},this.getVirtualDistanceFromEnd=()=>Math.max(this.getTotalSize()-this.getSize()-this.getScrollOffset(),0),this.getDistanceFromEnd=()=>Math.max(this.getMaxScrollOffset()-this.getScrollOffset(),0),this.isAtEnd=(l=this.options.scrollEndThreshold)=>this.getDistanceFromEnd()<=l,this.getOffsetForAlignment=(l,i,c=0)=>{if(!this.scrollElement)return 0;const d=this.getSize(),f=this.getScrollOffset();i==="auto"&&(i=l>=f+d?"end":"start"),i==="center"?l+=(c-d)/2:i==="end"&&(l-=d);const m=this.getMaxScrollOffset();return Math.max(Math.min(m,l),0)},this.getOffsetForIndex=(l,i="auto")=>{l=Math.max(0,Math.min(l,this.options.count-1));const c=this.getSize(),d=this.getScrollOffset(),f=this.measurementsCache[l];if(!f)return;if(i==="auto")if(f.end>=d+c-this.options.scrollPaddingEnd)i="end";else if(f.start<=d+this.options.scrollPaddingStart)i="start";else 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c=a[a.length-1];c&&c.clustered===l.clustered&&c.sv_class===l.sv_class?c.end=i:a.push({clustered:l.clustered,sv_class:l.sv_class,start:i,end:i})}),a}function D4(n){const a=new Map;for(const l of n)a.set(l.sv_class,(a.get(l.sv_class)??0)+l.count);return[...a].map(([l,i])=>({sv_class:l,count:i}))}const k4=45;function L4({role:n}){return n?r.jsx("span",{className:`sc-pill p-${n==="oncogene"?"onco":n}`,children:Hg[n]}):r.jsx("span",{style:{color:"var(--chev)"},children:"–"})}function $4({rows:n,shown:a,onToggle:l}){const i=E4(n);return r.jsx("div",{className:"sv-legend",role:"group","aria-label":"Show rows by gene role",children:db.filter(c=>i[c]>0).map(c=>r.jsxs("button",{type:"button",className:`sv-legend-item p-${c==="oncogene"?"onco":c}`,"aria-pressed":a.includes(c),onClick:()=>l(c),children:[Hg[c],r.jsx("span",{className:"sv-legend-n",children:i[c]})]},c))})}function s2({gene:n,chrom:a,pos:l,loc:i,query:c}){return r.jsxs(r.Fragment,{children:[r.jsxs("span",{className:"sv-end",children:[r.jsx("span",{className:"vt-gene",children:r.jsx(Il,{text:n||"–",query:c})}),i&&r.jsx("span",{className:"sv-loc",children:i})]}),r.jsx("span",{className:"vt-sub stack mono",children:a&&l!==null?Gr(a,l):"–"})]})}function hb(n){return n?n.replace(/,\s*/g,", "):"–"}function H4({label:n,sorted:a,onClick:l}){return r.jsxs("button",{type:"button",className:"vt-sort","data-active":!!a,onClick:l,title:`Sort by ${n.toLowerCase()}`,children:[n,a==="desc"?r.jsx(qu,{size:12,"aria-hidden":!0}):a==="asc"?r.jsx(fy,{size:12,"aria-hidden":!0}):r.jsx(qu,{size:12,"aria-hidden":!0,className:"vt-sort-idle"})]})}function U4({row:n,onLocate:a}){const[l,i]=C.useState(!1),c=n.left_chrom&&n.left_pos!==null?{chrom:n.left_chrom,pos:n.left_pos}:null,d=n.right_chrom&&n.right_pos!==null?{chrom:n.right_chrom,pos:n.right_pos}:null,f=[["Type",Ug(n.sv_type)],["Left breakpoint",c?`${Gr(c.chrom,c.pos)}${n.left_loc?`, ${n.left_loc}`:""}`:"–"],["Right 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_r=176,ym=34,bm=7,Sm=22,Lu=30,B4={deletion:"Del","tandem-duplication":"Dup",inversion:"Inv",translocation:"Tra"};function F4(n,a){return[Ql[n],_4[n],B4[n]].find(i=>zs(i,12)+8<=a)??""}function V4(n,a,l,i,c){const d=Math.min(c,l/2,i);return`M${n},${a+i} V${a+d} Q${n},${a} ${n+d},${a} H${n+l-d} Q${n+l},${a} ${n+l},${a+d} V${a+i} Z`}function G4({categories:n,total:a,litClass:l}){const[i,c]=ks(),d=C.useId(),[f,m]=C.useState(null),g=z4(n),v=Math.max(0,...n.map(z=>z.count)),x=ud(v,3),p=x[x.length-1],b=n.length,S=(g.length-1)*bm,j=n.some(z=>z.clustered)&&n.some(z=>!z.clustered),N=Math.max((c-Lu-6-S-(j?Sm-bm:0))/b,4),R=Math.min(26,N*.64),A=[],T=[];let O=Lu;g.forEach((z,te)=>{te>0&&(O+=g[te-1].clustered!==z.clustered?Sm:bm);const ie=O;for(let re=z.start;re<=z.end;re++)A[re]=O+(N-R)/2,O+=N;const J=T.find(re=>re.clustered===z.clustered&&re.x1>=ie-Sm-1),se=n.slice(z.start,z.end+1).reduce((re,$)=>re+$.count,0);J?(J.x1=O,J.count+=se):T.push({clustered:z.clustered,x0:ie,x1:O,count:se})});const 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d=n.pos,f=a.segments.find(p=>p.start<=d&&p.end>=d),m=a.depth&&l.length?yb(l,d):-1,g=a.window??1e5,v=m>=0&&Math.abs(l[m]-d)<=g?a.depth.cn[m]:null,x=f?vb(f):[];return r.jsxs(Kt,{x:n.x,y:c,width:i,children:[r.jsxs("b",{className:"mono",children:[a.chrom,":",zr(d)]}),f?r.jsxs(r.Fragment,{children:[r.jsxs("span",{children:["Battenberg ",x.join(", ")||"–",Bg(f)?" 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U5({cursor:n,placed:a,at:l,width:i}){const c=l(n),d=["tumour","normal"].map(m=>{const g=a[m];if(!g||!g.at.length)return null;const v=yb(g.at,c),x=p=>p===null?"–":p.toFixed(2);return{source:m,chrom:g.chrom[v],pos:g.pos[v],text:`LogR ${x(g.logr[v])}, BAF ${x(g.baf[v])}`}}),f=d.find(Boolean);return f?r.jsxs(Kt,{x:n,y:qa,width:i,children:[r.jsxs("b",{className:"mono",children:[f.chrom,":",f.pos.toLocaleString("en-US")]}),d.map(m=>m&&r.jsxs("span",{children:[bg[m.source],": ",m.text]},m.source)),r.jsx("i",{children:"The nearest locus kept"})]}):null}const B5=["deletion","tandem-duplication","inversion","translocation"];function Fa({kind:n,colour:a,label:l}){return r.jsxs("span",{className:"flex items-center gap-1.5",children:[r.jsx("span",{className:`cnsv-key-${n}`,style:{background:n==="dot"||n==="line"?a:void 0,color:a},"aria-hidden":!0}),l]})}function F5({chrom:n,withData:a,genome:l,allowGenome:i,onPick:c,onGenome:d}){return r.jsxs("div",{className:"cnsv-picker",role:"group","aria-label":"Chromosome",children:[i&&r.jsx("button",{type:"button",className:"cnsv-chip cnsv-chip-genome","aria-pressed":l,onClick:d,children:"Genome"}),Ir.map(f=>r.jsx("button",{type:"button",className:"cnsv-chip","aria-pressed":!l&&f===n,"data-empty":!a.has(f)||void 0,"aria-label":`Chromosome ${f}`,onClick:()=>c(f),children:f},f))]})}const V5=C.forwardRef(function({envelope:a,loading:l,rawGenome:i,rawGenomeLoading:c,picked:d,chrom:f,onChrom:m,mode:g,onMode:v,genome:x,onGenome:p},b){const[S,j]=ks(900),[N,R]=C.useState({span:Tm(f),smooth:!1});C.useEffect(()=>R({span:Tm(f),smooth:!1}),[f]);const A=Tm(f),T=N.span[1]-N.span[0]<A[1]-A[0]-1,O=a==null?void 0:a.data,M=new Set((O==null?void 0:O.chromosomes)??[]),E=g==="raw"&&x,_=D=>{p(!1),m(D)};return r.jsx(hs,{ref:b,title:"Copy number and rearrangements by chromosome",subtitle:g==="integrated"?`BAF, rearrangements and read depth along chromosome ${f}`:E?"Battenberg's raw LogR and BAF across 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Y5({fusion:n,top:a}){const l=(i,c,d,f)=>r.jsxs("span",{className:"rna-read","data-kind":f,children:[r.jsx("span",{className:"rna-read-label",children:d}),r.jsx("span",{className:"rna-read-track","aria-hidden":!0,children:r.jsx("span",{style:{width:`${c&&i?Math.max(i/c*100,3):0}%`}})}),r.jsx("span",{className:"rna-read-n mono",children:i??"–"})]});return r.jsxs("span",{className:"rna-reads",children:[l(n.split_reads,a.split,"Split","split"),l(n.span_reads,a.span,"Spanning","span")]})}function X5({pair:n,top:a,onLocate:l}){const[i,c]=C.useState(!1),d=I5(n),f=[...new Set(n.breakpoints.flatMap(g=>Object.keys(g.details)))],m=n.breakpoints.length>0||Object.keys(n.details).length>0||n.description;return r.jsxs("li",{className:"rna-fusion","data-on":n.highlighted||void 0,"data-open":i||void 0,children:[r.jsxs("div",{className:"rna-fusion-main",children:[r.jsxs("span",{className:"rna-junction","aria-label":`${n.gene1??"?"} fused to 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r.jsxs("section",{className:"rna-section","aria-label":"Fusions",children:[r.jsxs("div",{className:"rna-head",children:[r.jsx("h3",{className:"sv-h",children:"Fusions"}),r.jsx(es,{label:"Fusion set",value:l,onChange:i,options:[{value:"confident",label:`Confident ${n.confident.length}`},{value:"rescued",label:`Rescued ${n.rescued.length}`}]})]}),c.length?r.jsx("ul",{className:"rna-fusions",children:c.map((f,m)=>r.jsx(X5,{pair:f,top:d,onLocate:a},`${f.gene1}-${f.gene2}-${m}`))}):r.jsx("p",{className:"sv-empty",children:l==="confident"?"No confident fusions.":"No rescued fusions."}),n.fusion_report&&r.jsxs("a",{className:"rna-report",href:n.fusion_report,target:"_blank",rel:"noreferrer",children:["Open the fusion callers' report ",r.jsx(yy,{size:13,"aria-hidden":!0})]})]})}function Z5({gene:n,projects:a,top:l}){return r.jsxs("li",{className:"rna-gene",children:[r.jsxs("span",{className:"rna-gene-name",children:[r.jsx("b",{children:n.gene}),n.band&&r.jsx("span",{className:"mono",children:n.band})]}),r.jsx("span",{className:"rna-folds","data-single":a.length===1||void 0,children:a.filter(i=>n.folds[i]!==void 0).map(i=>r.jsxs("span",{className:"rna-fold",title:`log2 fold change ${n.folds[i].toFixed(2)} against project ${i}`,children:[a.length>1&&r.jsxs("span",{className:"rna-fold-p",children:["p",i]}),r.jsx("span",{className:"rna-fold-track","aria-hidden":!0,children:r.jsx("span",{style:{width:`${l?Math.max(n.folds[i]/l*100,3):0}%`}})}),r.jsxs("span",{className:"rna-fold-n mono",children:[n.folds[i].toFixed(2)," ",r.jsxs("i",{children:["(",q5(n.folds[i]),")"]})]})]},i))}),n.cancers&&r.jsx("span",{className:"rna-cancers",title:n.cancers,children:n.cancers})]})}function J5({rna:n}){const[a,l]=C.useState("report"),i=P5(n.overexpressed,a),c=Math.max(0,...n.overexpressed.map(Sg));return r.jsxs("section",{className:"rna-section","aria-label":"Overexpressed cancer genes",children:[r.jsxs("div",{className:"rna-head",children:[r.jsxs("h3",{className:"sv-h",children:["Overexpressed cancer genes ",r.jsx("span",{className:"rna-count",children:n.overexpressed.length})]}),n.overexpressed.length>1&&r.jsx(es,{label:"Sort genes",value:a,onChange:l,options:[{value:"report",label:"As reported"},{value:"fold",label:"Largest"},{value:"gene",label:"A–Z"}]})]}),i.length?r.jsxs(r.Fragment,{children:[r.jsx("ul",{className:"rna-genes",children:i.map(d=>r.jsx(Z5,{gene:d,projects:n.projects,top:c},d.gene))}),r.jsxs("p",{className:"rna-note",children:["log2 fold change over the mean of ",n.projects.length>1?"each":"its"," cohort (project ",n.projects.join(", "),"), as the cohort was when the report ran."]})]}):r.jsx("p",{className:"sv-empty",children:"No overexpressed cancer genes."})]})}const W5=C.forwardRef(function({envelope:a,loading:l,picked:i,sampleLabel:c,onLocate:d},f){var p;const m=((p=a==null?void 0:a.data)==null?void 0:p.experiments)??[],[g,v]=C.useState(null),x=m.find(b=>b.node===g)??m[0];return r.jsx(hs,{ref:f,title:"RNA",subtitle:`Fusions and overexpressed cancer genes, ${c}`,lineage:(a==null?void 0:a.lineage)??[],picked:i,info:"rna",className:"rna",controls:m.length>1?r.jsx(es,{label:"RNA experiment",value:(x==null?void 0:x.node)??"",onChange:v,options:m.map(b=>({value:b.node,label:b.node.split("-").slice(-2).join("-")}))}):void 0,children:r.jsx(Hn,{label:"RNA",envelope:a,loading:l,skeletonHeight:260,children:()=>x?r.jsxs("div",{className:"rna-body",children:[r.jsx(K5,{rna:x,onLocate:d},`f-${x.node}`),r.jsx(J5,{rna:x},`o-${x.node}`)]}):null})})});function eR(n,a=[],l=new Date){const i=a.filter(f=>typeof f=="number").map(f=>Math.floor(f/365)),c=typeof n=="number"?Math.max(l.getFullYear()-n-1,0):null,d=[...i,...c===null?[]:[c]];return d.length?Math.max(...d):null}function tR(n){return typeof n=="number"?Math.round(n/365.25*10)/10:null}const nR=n=>(n??[]).filter(a=>a.includes("XPRO")),sR=n=>(n??"").replace(/^LEVEL_/,"")||"–",aR={LEVEL_1:"#33A02C",LEVEL_2:"#1F78B4",LEVEL_3A:"#984EA3",LEVEL_3B:"#BE98CE",LEVEL_4:"#424242",LEVEL_R1:"#EE3424",LEVEL_R2:"#F79A92"},lR=(n,a)=>a||aR[n??""]||"var(--chev)";function Sb(n){return n&&n.replace(/<[^>]+>/g," ").replace(/&nbsp;/g," ").replace(/&amp;/g,"&").replace(/\s+/g," ").trim()||null}function iR(n){return(n??"").split(",").map(a=>a.split("+").map(l=>l.trim()).filter(Boolean)).filter(a=>a.length)}const zm=n=>(n??"").split(",").map(a=>a.trim()).filter(Boolean),Wu=n=>n?n.charAt(0)+n.slice(1).toLowerCase():null;function ia({label:n,off:a,title:l,children:i}){return r.jsxs("p",{className:"pp-line","data-off":a||void 0,title:l,children:[n&&r.jsx("span",{className:"pp-label",children:n}),i]})}function oR({data:n,sample:a,concordance:l}){var v;const i=n.individual,c=n.samples.filter(x=>x.category==="TUMOR"),d=[...new Set(c.map(x=>{var p;return(p=x.disease)==null?void 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0,title:"Conpair's check that the samples come from the same person. 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birth`,children:["Collected at ",i," years"]})]})}function cR({children:n}){var m;const[a,l]=C.useState(!1),i=C.useRef(null),c=C.useRef(null),[d,f]=C.useState(null);return C.useLayoutEffect(()=>{if(!a||!i.current)return;const g=i.current.getBoundingClientRect();f({top:g.bottom+8,left:g.left-8});const v=x=>{var b,S;const p=!((b=c.current)!=null&&b.contains(x.target))&&!((S=i.current)!=null&&S.contains(x.target));(x instanceof KeyboardEvent&&x.key==="Escape"||!(x instanceof KeyboardEvent)&&p)&&l(!1)};return window.addEventListener("pointerdown",v),window.addEventListener("keydown",v),()=>{window.removeEventListener("pointerdown",v),window.removeEventListener("keydown",v)}},[a]),r.jsxs(r.Fragment,{children:[r.jsx("button",{ref:i,type:"button",className:"sc-ib sm","aria-expanded":a,"aria-label":"Patient and sample details",title:"Patient and sample 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gR({data:n,sample:a,sampleLabel:l,hovered:i,onHover:c}){const d=Va-jn.left-jn.right,f=Va-jn.top-jn.bottom,m=p=>jn.left+Math.min(Math.max(p,0),1)*d,g=p=>jn.top+(1-Math.min(Math.max(p,0),1))*f,v=n.mutations.map(p=>({m:p,dmp:eM(p,n.matched),wgs:p.wgs[a]})).filter(p=>!!p.dmp&&!!p.wgs&&typeof p.wgs.vaf=="number"),x=v.find(p=>p.m.rank===i);return r.jsxs("figure",{className:"dmp-plot",children:[r.jsxs("figcaption",{children:[l," WGS against DMP VAF"]}),r.jsxs("div",{className:"dmp-plot-box",style:{width:Va},children:[r.jsxs("svg",{width:Va,height:Va,role:"img","aria-label":`VAF of ${v.length} DMP mutations in ${l}'s WGS against the 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0,cx:m(b.vaf),cy:g(S.vaf),r:p.rank===i?6.5:5,onMouseEnter:()=>c(p.rank),onMouseLeave:()=>c(null)},p.rank))]}),x&&r.jsxs(Kt,{x:m(x.dmp.vaf),y:g(x.wgs.vaf)-8,width:Va,above:!0,children:[r.jsxs("span",{className:"ctip-title",children:[x.m.gene," ",x.m.protein_change]}),r.jsxs("span",{className:"ctip-row",children:[r.jsxs("span",{children:["DMP, ",Oy(x.dmp.sample,n.dmp_id)]}),r.jsx("b",{children:x.dmp.vaf.toFixed(2)})]}),r.jsxs("span",{className:"ctip-row",children:[r.jsxs("span",{children:[l," WGS"]}),r.jsxs("b",{children:[x.wgs.vaf.toFixed(2),typeof x.wgs.depth=="number"&&r.jsxs("i",{children:[" ",x.wgs.alt_reads??0," of ",x.wgs.depth," reads"]})]})]}),r.jsx("span",{className:"ctip-note",children:x.wgs.called?`${l}'s WGS calls it.`:`${l}'s WGS does not call it.`})]})]})]})}const jb=n=>typeof n=="number"?n.toFixed(2):"–";function Vg({samples:n,data:a,withVaf:l}){return r.jsx("span",{className:"dmp-chips",children:n.map(i=>{const c=i.dmp_sample===a.matched,d=typeof i.alt_reads=="number"&&typeof i.depth=="number"?`${i.alt_reads} of ${i.depth} reads`:null,f=[i.dmp_sample,d,c?"matched to this sample":i.matched?"matched to another sample of the report":null].filter(Boolean).join(", ");return r.jsxs("span",{className:"dmp-chip","data-mine":c||void 0,title:f,children:[Oy(i.dmp_sample,a.dmp_id),l&&r.jsx("b",{className:"mono",children:jb(i.vaf)})]},i.dmp_sample)})})}function pR({m:n}){return r.jsxs("span",{className:"dmp-name",title:n.keyword??void 0,children:[r.jsx("b",{children:n.gene??"–"})," ",n.protein_change]})}function xR({data:n,sample:a,label:l,onCall:i}){const[c,d]=C.useState(null);if(!n.mutations.length)return r.jsx("p",{className:"sv-empty",children:"cBioPortal lists no DMP mutations for this patient."});const f=!!a&&n.wgs_samples.includes(a);return r.jsxs("div",{className:"dmp-mutations","data-plot":f||void 0,children:[r.jsx("div",{className:"tx-scroll",children:r.jsxs("table",{className:"tx-table 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reads",b=r.jsx("span",{className:"dmp-mark","data-called":v.called||void 0,"aria-hidden":!0}),S=r.jsxs(r.Fragment,{children:[b,r.jsx("span",{className:"mono",children:jb(v.vaf)}),r.jsx("span",{className:"dmp-reads mono",children:p})]}),j=v.called?`${l(g)} calls it`:`${l(g)} does not call it`;return r.jsx("td",{className:"dmp-wgs","data-current":x||void 0,children:v.called&&x&&v.call_pos!==null?r.jsx("button",{type:"button",className:"dmp-call",title:`${j}. Show the call in Mutations`,onClick:()=>i(m,v.call_pos),children:S}):r.jsx("span",{className:"dmp-call",title:typeof v.depth=="number"?j:"The pileup returned no reads; the report shows 0",children:S})},g)})]},m.rank))})]})}),f&&a&&r.jsx(gR,{data:n,sample:a,sampleLabel:l(a),hovered:c,onHover:d})]})}function vR({data:n}){return n.svs.length?r.jsx("div",{className:"tx-scroll",children:r.jsxs("table",{className:"tx-table dmp-table",children:[r.jsx("thead",{children:r.jsxs("tr",{children:[r.jsx("th",{scope:"col",children:"Genes"}),r.jsx("th",{scope:"col",children:"Class"}),r.jsx("th",{scope:"col",children:"Event"}),r.jsx("th",{scope:"col",children:"DMP samples"}),r.jsx("th",{scope:"col",children:"Comments"})]})}),r.jsx("tbody",{children:n.svs.map(a=>r.jsxs("tr",{children:[r.jsx("td",{children:r.jsxs("span",{className:"dmp-name",children:[r.jsx("b",{children:a.gene1??"–"}),a.gene2&&a.gene2!==a.gene1&&r.jsxs(r.Fragment,{children:[r.jsx("span",{className:"dmp-join","aria-label":"and"}),r.jsx("b",{children:a.gene2})]})]})}),r.jsx("td",{children:zy(a.classification)??"–"}),r.jsx("td",{children:a.event_info??"–"}),r.jsx("td",{children:r.jsx(Vg,{samples:a.samples,data:n})}),r.jsx("td",{className:"dmp-comment",children:a.comments&&a.comments!=="-"?a.comments:"–"})]},a.rank))})]})}):r.jsx("p",{className:"sv-empty",children:"cBioPortal lists no DMP structural variants for this patient."})}function yR({data:n}){return n.cnas.length?r.jsx("div",{className:"tx-scroll",children:r.jsxs("table",{className:"tx-table dmp-table",children:[r.jsx("thead",{children:r.jsxs("tr",{children:[r.jsx("th",{scope:"col",children:"Gene"}),r.jsx("th",{scope:"col",children:"Alteration"}),r.jsx("th",{scope:"col",children:"DMP samples"})]})}),r.jsx("tbody",{children:n.cnas.map(a=>{var l;return r.jsxs("tr",{children:[r.jsx("td",{children:r.jsxs("span",{className:"dmp-name",children:[r.jsx("b",{children:a.gene??"–"}),a.cytoband&&a.cytoband!=="-"&&r.jsx("span",{className:"dmp-band mono",children:a.cytoband})]})}),r.jsx("td",{children:r.jsx("span",{className:"dmp-cna","data-kind":(l=a.alteration)==null?void 0:l.toLowerCase(),children:a.alteration==="GAIN"?"Gain":a.alteration==="LOSS"?"Loss":a.alteration??"–"})}),r.jsx("td",{children:r.jsx(Vg,{samples:a.samples,data:n})})]},a.rank)})})]})}):r.jsx("p",{className:"sv-empty",children:"cBioPortal lists no DMP copy-number alterations for this patient."})}const bR={mutations:"mutations",svs:"structural variants",cnas:"copy-number alterations"},SR=C.forwardRef(function({envelope:a,loading:l,picked:i,sample:c,label:d,onCall:f},m){const[g,v]=C.useState("mutations"),x=(a==null?void 0:a.status)==="ok"?a.data:null;return r.jsx(hs,{ref:m,title:"DMP results",subtitle:x!=null&&x.dmp_id?`MSK-IMPACT calls for ${x.dmp_id}, from cBioPortal`:"MSK-IMPACT calls, from cBioPortal",lineage:(a==null?void 0:a.lineage)??[],picked:i,info:"dmp",className:"dmp",controls:x?r.jsxs(r.Fragment,{children:[r.jsx(es,{label:"DMP calls",value:g,onChange:v,options:[{value:"mutations",label:`Mutations ${x.mutations.length}`},{value:"svs",label:`SVs ${x.svs.length}`},{value:"cnas",label:`CNAs ${x.cnas.length}`}]}),x.cbioportal&&r.jsx("a",{className:"sc-ib dmp-cbio",href:x.cbioportal,target:"_blank",rel:"noreferrer","aria-label":"Open the patient in cBioPortal",title:"Open the patient in cBioPortal",children:r.jsx("img",{src:fR,alt:"",width:18,height:18})})]}):void 0,footer:x&&g==="mutations"&&x.mutations.length>0&&x.wgs_samples.length>0?r.jsxs("span",{className:"dmp-legend",children:[r.jsxs("span",{children:[r.jsx("span",{className:"dmp-mark","data-called":!0,"aria-hidden":!0})," Called in that tumour's WGS"]}),r.jsxs("span",{children:[r.jsx("span",{className:"dmp-mark","aria-hidden":!0})," Not called; VAF from its reads"]})]}):void 0,children:r.jsx(Hn,{label:"DMP results",envelope:a,loading:l,skeletonHeight:180,children:p=>r.jsxs(r.Fragment,{children:[p.timed_out.length>0&&r.jsxs("p",{className:"dmp-warn",role:"note",children:["cBioPortal did not answer for the ",p.timed_out.map(b=>bR[b]??b).join(" and ")," when the report ran, so they may be missing here. 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