renkin 0.1.0

package/README.md

@@ -0,0 +1,309 @@
+# RENKIN — Retrosynthesis Engine
+
+> **Computer-Aided Synthesis Planning (CASP) · Pure Rust · WebAssembly · Python**  
+> Named after 錬金 (れんきん, *renkin*) — Japanese for alchemy: just as alchemists transformed base metals into gold, RENKIN transforms target molecules back into cheap starting materials.
+
+[![Crates.io](https://img.shields.io/crates/v/renkin)](https://crates.io/crates/renkin)
+[![License: MIT](https://img.shields.io/badge/license-MIT-blue)](LICENSE)
+[![WASM](https://img.shields.io/badge/WASM-ready-brightgreen)](https://github.com/kent-tokyo/renkin/tree/master/demo)
+[![Pure Rust](https://img.shields.io/badge/Pure-Rust-orange?logo=rust)](https://www.rust-lang.org)
+
+[日本語版 README](./README_ja.md)
+
+---
+
+## What is RENKIN?
+
+RENKIN is an open-source **retrosynthesis engine** for **computer-aided synthesis planning (CASP)** that automatically discovers optimal chemical reaction routes from a target molecule back to cheap, commercially available starting materials — a core problem in **drug discovery** and **medicinal chemistry**.
+
+Built entirely in Rust with the [`chematic`](https://docs.rs/chematic/) cheminformatics crate, RENKIN solves the fundamental speed and dependency problems of existing Python-based CASP tools (AiZynthFinder, ASKCOS, Retro\*, etc.). It ships as:
+
+- **CLI** — single binary, `cargo build --release`
+- **Python package** — `import renkin` via PyO3 + maturin
+- **WASM module** — 493 KB bundle, runs in the browser with no server
+
+All from a single pure-Rust codebase with zero C/C++ dependencies.
+
+---
+
+## Key Features
+
+| Feature | Detail |
+|---|---|
+| **Pure Rust** | Zero C/C++ dependencies. Cross-platform with `cargo build` alone |
+| **A\* / AND-OR Tree Search** | Retro\*-equivalent algorithm proven more efficient than MCTS for retrosynthesis |
+| **SA Score heuristic** | `chematic::chem::sa_score` guides search toward synthetically accessible precursors |
+| **Beam search** | `--beam-width N` limits heap size for memory-bounded exploration |
+| **Graph-based Ar–Ar cleavage** | Bridge-bond detection via DFS — correctly handles biaryl (Suzuki) disconnections |
+| **Parallel rule application** | `rayon` parallelises SMIRKS rule evaluation; sequential fallback on WASM |
+| **Python bindings** | `maturin` extension — `import renkin; renkin.find_routes(...)` |
+| **WASM-ready** | 493 KB bundle via `wasm-pack`; browser demo with 2D structure rendering |
+| **~400 building blocks** | Curated commercial starting materials covering esters, amines, halides, heterocycles, amino acids, sulfonyl chlorides, boronic acids and more |
+| **Benchmark CLI** | `renkin-bench --input targets.smi` produces a JSON success/timing report |
+
+---
+
+## Architecture
+
+```
+Target SMILES
+     │
+     ▼
+┌─────────────────────────┐
+│     chem_env.rs         │  ← chematic wrapper
+│  - SMILES parse         │     SMARTS VF2 building-block check
+│  - SMIRKS retro rules   │     fragment sanitization
+│  - Building block check │     HashMap O(1) pre-filter
+└────────────┬────────────┘
+             │  par_iter (rayon / sequential on WASM)
+             ▼
+┌─────────────────────────┐
+│      search.rs          │  ← A* / AND-OR Tree Search
+│  - Priority queue       │     SA Score heuristic
+│  - Closed list          │     beam search pruning
+│  - Degenerate filter    │
+└────────────┬────────────┘
+             │
+             ▼
+┌─────────────────────────┐
+│      score.rs           │  ← Heuristic / Cost Function
+│  - SA Score (chematic)  │     h = Σ(1 + 0.5·(sa−1)/9)
+│  - MW step cost         │     g = Σ(1 + total_mw/2000)
+└────────────┬────────────┘
+             │
+             ▼
+  JSON  ←  CLI / Python / WASM
+```
+
+---
+
+## Technology Stack
+
+- **Language**: Rust (Edition 2024)
+- **Cheminformatics**: [`chematic`](https://crates.io/crates/chematic) v0.4.9+
+  - `chematic-smiles` — SMILES parsing & canonical SMILES
+  - `chematic-smarts` — VF2 substructure matching (building block identity)
+  - `chematic-rxn` — SMIRKS reaction application (`run_reactants`)
+  - `chematic-chem` — SA Score, molecular weight, aromaticity descriptors
+- **Search**: A\* + AND/OR Tree (Retro\* equivalent)
+- **Parallelism**: [`rayon`](https://crates.io/crates/rayon) — parallel SMIRKS rule application
+- **Python**: [`PyO3`](https://pyo3.rs) + [`maturin`](https://www.maturin.rs)
+- **WASM**: [`wasm-bindgen`](https://rustwasm.github.io/wasm-bindgen/) + [`wasm-pack`](https://rustwasm.github.io/wasm-pack/)
+
+---
+
+## Installation
+
+### As a library
+
+```toml
+# Cargo.toml
+[dependencies]
+renkin = "0.1"
+```
+
+### CLI (from source)
+
+```bash
+git clone https://github.com/kent-tokyo/renkin
+cd renkin
+cargo build --release
+```
+
+### Python
+
+```bash
+pip install maturin
+git clone https://github.com/kent-tokyo/renkin && cd renkin
+python -m venv .venv && source .venv/bin/activate
+maturin develop --features python
+```
+
+---
+
+## Getting Started
+
+### CLI
+
+```bash
+# Retrosynthesis (Aspirin, depth 3)
+./target/release/renkin --target "CC(=O)Oc1ccccc1C(=O)O" --depth 3
+
+# With beam search (top-50 nodes)
+./target/release/renkin --target "CC(=O)Oc1ccccc1C(=O)O" --depth 5 --beam-width 50
+```
+
+```
+--target / -t      Target molecule SMILES
+--depth  / -d      Max retrosynthesis depth (default: 5)
+--max-routes / -n  Max routes to return (default: 5)
+--beam-width / -w  Beam search width, 0 = unlimited A* (default: 0)
+--building-blocks  Path to .smi file of commercial starting materials
+```
+
+### Python
+
+```python
+import renkin, json
+
+routes = json.loads(renkin.find_routes(
+    "CC(=O)Oc1ccccc1C(=O)O",   # Aspirin
+    depth=3,
+    max_routes=5,
+))
+print(routes["routes_found"])   # number of routes found
+for r in routes["routes"]:
+    print(r["depth"], [s["rule"] for s in r["steps"]])
+```
+
+### WASM
+
+```bash
+wasm-pack build --target web --no-default-features
+# Output: pkg/  (npm-ready package)
+# Browser demo: python3 -m http.server 8080 → http://localhost:8080/demo/
+```
+
+```javascript
+import init, { find_routes } from './pkg/renkin.js';
+await init();
+
+const result = JSON.parse(find_routes(
+  "CC(=O)Oc1ccccc1C(=O)O",  // target SMILES
+  3,   // depth
+  5,   // max_routes
+  0,   // beam_width (0 = unlimited A*)
+));
+console.log(result.routes_found);
+```
+
+### Benchmark
+
+```bash
+# Input: one SMILES per line, optional name after whitespace
+./scripts/run_benchmark.sh --input data/benchmark_targets.smi --depth 5
+```
+
+```json
+{
+  "total": 42, "solved": 37, "success_rate": 0.88,
+  "avg_depth": 1.05, "avg_time_ms": 2.5,
+  "results": [...]
+}
+```
+
+---
+
+## CLI Output Example
+
+```json
+{
+  "target": "CC(=O)Oc1ccccc1C(=O)O",
+  "routes_found": 2,
+  "routes": [
+    {
+      "steps": [
+        {
+          "rule": "ester_cleavage",
+          "target": "CC(=O)Oc1ccccc1C(=O)O",
+          "precursors": ["CC(=O)O", "Oc1ccccc1C(=O)O"]
+        }
+      ],
+      "depth": 1
+    }
+  ]
+}
+```
+
+**depth: 0** means the target itself is a commercially available starting material (buy directly).
+
+---
+
+## Retro-Rules (14 total)
+
+| Rule | Reaction type | Strategy |
+|---|---|---|
+| `ester_cleavage` | Ester → acid + alcohol | SMIRKS |
+| `amide_cleavage` | Amide → acid + amine | SMIRKS |
+| `friedel_crafts_acylation_retro` | Ar-C(=O)R → Ar-H + acyl chloride | SMIRKS |
+| `aryl_carboxylation_retro` | Ar-COOH → Ar-H + CO₂ surrogate | SMIRKS |
+| `aryl_amine_retro` | Ar-N → Ar-H + amine | SMIRKS |
+| `buchwald_hartwig_retro` | Ar-N → Ar-Br + amine | SMIRKS |
+| `aryl_ether_retro` | Ar-O → Ar-OH + fragment | SMIRKS |
+| `suzuki_retro` | Ar-Ar → Ar-Br + Ar-H | Graph (bridge-bond DFS) |
+| `cc_single_cleavage` | C–C → two fragments | SMIRKS |
+| `wittig_retro` | C=C → C=O + C=O | SMIRKS |
+| `reductive_amination_retro` | C–N → C=O + amine | SMIRKS |
+| `cn_aliphatic_cleavage` | C–N → two fragments | SMIRKS |
+| `co_aliphatic_cleavage` | C–O → two fragments | SMIRKS |
+| `alcohol_oxidation_retro` | C–OH → C=O | SMIRKS |
+
+`suzuki_retro` uses a graph-based bridge-bond algorithm instead of SMIRKS to correctly handle symmetric biaryls (biphenyl, 4-fluorobiphenyl, etc.) without the BFS leakage artifacts that affect SMIRKS-based approaches.
+
+---
+
+## Project Structure
+
+```
+renkin/
+├── Cargo.toml
+├── src/
+│   ├── lib.rs           # public library (DEFAULT_BUILDING_BLOCKS, re-exports)
+│   ├── main.rs          # CLI binary
+│   ├── bin/
+│   │   └── benchmark.rs # renkin-bench binary
+│   ├── chem_env.rs      # chematic wrapper — parse, retro rules, BB check
+│   ├── score.rs         # SA Score heuristic + step cost
+│   ├── search.rs        # A* / AND-OR tree engine + beam pruning
+│   ├── python.rs        # PyO3 bindings (--features python)
+│   └── wasm.rs          # wasm-bindgen bindings (cfg = wasm32)
+├── data/
+│   ├── building_blocks.smi      # Commercial starting materials (~400 entries)
+│   └── benchmark_targets.smi   # 42-molecule benchmark set
+├── demo/
+│   └── index.html       # Browser WASM demo with 2D structure rendering
+└── scripts/
+    └── run_benchmark.sh # Benchmark runner with human-readable summary
+```
+
+---
+
+## Roadmap
+
+- [x] **Phase 1** — SMIRKS retro-reaction rules + fragment sanitization
+- [x] **Phase 2** — A\* / AND-OR tree search, closed list, degenerate-route filter
+- [x] **Phase 3** — SA Score heuristic + beam search (`--beam-width`)
+- [x] **Phase 4** — Parallel rule application (`rayon`; sequential fallback on WASM)
+- [x] **Phase 5** — Python bindings (PyO3 + maturin)
+- [x] **Phase 6** — WASM build (493 KB, `pkg/` npm-ready)
+- [x] **Phase 7** — Benchmark CLI (`renkin-bench`)
+- [x] **Phase 8** — 21 unit tests, SMIRKS rules 5→14, building blocks ~30→~400
+- [x] **Phase 9** — Browser WASM demo (SmilesDrawer 2D rendering), benchmark target set
+- [x] **Phase 10** — Graph-based biaryl cleavage (suzuki_retro), O(1) BB HashMap index
+- [ ] **Phase 11** — Formal benchmark vs. AiZynthFinder / Retro\* on USPTO-50k
+- [ ] **Phase 12** — PyPI / npm publish
+
+---
+
+## Competitive Landscape
+
+| Tool | Language | Algorithm | WASM | Zero-dep build |
+|---|---|---|---|---|
+| **ASKCOS** | Python | MCTS / A\* | No | No (Docker, 64 GB RAM) |
+| **AiZynthFinder** | Python | MCTS primary | No | No (conda, model download) |
+| **IBM RXN** | Closed | Transformer | No | No (cloud only) |
+| **SYNTHIA** | Closed | SMARTS + AND/OR | No | No (proprietary) |
+| **Retro\*** | Python | A\* + AND/OR | No | No (unmaintained) |
+| **★ RENKIN** | **Rust** | **A\* + AND/OR** | **Yes** | **Yes (`cargo build`)** |
+
+All existing open CASP tools are Python-based. RENKIN fills the vacant niche: Rust-native, WASM-deployable, zero-dependency, A\* search.
+
+---
+
+## License
+
+MIT
+
+---
+
+*GitHub Topics: `retrosynthesis` `cheminformatics` `wasm` `rust` `drug-discovery` `casp` `synthesis-planning` `computational-chemistry`*

package/package.json

@@ -0,0 +1,36 @@
+{
+  "name": "renkin",
+  "type": "module",
+  "description": "Ultra-fast retrosynthesis engine for computer-aided synthesis planning (CASP) — pure Rust, WASM-ready, Python bindings via PyO3",
+  "version": "0.1.0",
+  "license": "MIT",
+  "repository": {
+    "type": "git",
+    "url": "https://github.com/kent-tokyo/renkin"
+  },
+  "files": [
+    "renkin_bg.wasm",
+    "renkin.js",
+    "renkin.d.ts"
+  ],
+  "main": "renkin.js",
+  "homepage": "https://github.com/kent-tokyo/renkin",
+  "types": "renkin.d.ts",
+  "sideEffects": [
+    "./snippets/*"
+  ],
+  "bugs": {
+    "url": "https://github.com/kent-tokyo/renkin/issues"
+  },
+  "keywords": [
+    "retrosynthesis",
+    "cheminformatics",
+    "chemistry",
+    "wasm",
+    "webassembly",
+    "drug-discovery",
+    "casp",
+    "smiles",
+    "synthesis-planning"
+  ]
+}

package/renkin.d.ts

@@ -0,0 +1,63 @@
+/* tslint:disable */
+/* eslint-disable */
+
+/**
+ * Find retrosynthetic routes for a target molecule (WASM entry point).
+ *
+ * Returns a JSON string with the retrosynthesis result.
+ *
+ * # Arguments
+ * * `target`      - Target molecule SMILES
+ * * `depth`       - Maximum retrosynthesis depth
+ * * `max_routes`  - Maximum number of routes
+ * * `beam_width`  - Beam search width; 0 = unlimited A*
+ *
+ * # Example (JavaScript)
+ * ```js
+ * import init, { find_routes } from '@renkin/wasm';
+ * await init();
+ * const result = JSON.parse(find_routes("CC(=O)Oc1ccccc1C(=O)O", 3, 5, 0));
+ * console.log(result.routes_found);
+ * ```
+ */
+export function find_routes(target: string, depth: number, max_routes: number, beam_width: number): string;
+
+/**
+ * Return the crate version string.
+ */
+export function version(): string;
+
+export type InitInput = RequestInfo | URL | Response | BufferSource | WebAssembly.Module;
+
+export interface InitOutput {
+    readonly memory: WebAssembly.Memory;
+    readonly find_routes: (a: number, b: number, c: number, d: number, e: number) => [number, number];
+    readonly version: () => [number, number];
+    readonly __wbindgen_externrefs: WebAssembly.Table;
+    readonly __wbindgen_malloc: (a: number, b: number) => number;
+    readonly __wbindgen_realloc: (a: number, b: number, c: number, d: number) => number;
+    readonly __wbindgen_free: (a: number, b: number, c: number) => void;
+    readonly __wbindgen_start: () => void;
+}
+
+export type SyncInitInput = BufferSource | WebAssembly.Module;
+
+/**
+ * Instantiates the given `module`, which can either be bytes or
+ * a precompiled `WebAssembly.Module`.
+ *
+ * @param {{ module: SyncInitInput }} module - Passing `SyncInitInput` directly is deprecated.
+ *
+ * @returns {InitOutput}
+ */
+export function initSync(module: { module: SyncInitInput } | SyncInitInput): InitOutput;
+
+/**
+ * If `module_or_path` is {RequestInfo} or {URL}, makes a request and
+ * for everything else, calls `WebAssembly.instantiate` directly.
+ *
+ * @param {{ module_or_path: InitInput | Promise<InitInput> }} module_or_path - Passing `InitInput` directly is deprecated.
+ *
+ * @returns {Promise<InitOutput>}
+ */
+export default function __wbg_init (module_or_path?: { module_or_path: InitInput | Promise<InitInput> } | InitInput | Promise<InitInput>): Promise<InitOutput>;

package/renkin.js

@@ -0,0 +1,246 @@
+/* @ts-self-types="./renkin.d.ts" */
+
+/**
+ * Find retrosynthetic routes for a target molecule (WASM entry point).
+ *
+ * Returns a JSON string with the retrosynthesis result.
+ *
+ * # Arguments
+ * * `target`      - Target molecule SMILES
+ * * `depth`       - Maximum retrosynthesis depth
+ * * `max_routes`  - Maximum number of routes
+ * * `beam_width`  - Beam search width; 0 = unlimited A*
+ *
+ * # Example (JavaScript)
+ * ```js
+ * import init, { find_routes } from '@renkin/wasm';
+ * await init();
+ * const result = JSON.parse(find_routes("CC(=O)Oc1ccccc1C(=O)O", 3, 5, 0));
+ * console.log(result.routes_found);
+ * ```
+ * @param {string} target
+ * @param {number} depth
+ * @param {number} max_routes
+ * @param {number} beam_width
+ * @returns {string}
+ */
+export function find_routes(target, depth, max_routes, beam_width) {
+    let deferred2_0;
+    let deferred2_1;
+    try {
+        const ptr0 = passStringToWasm0(target, wasm.__wbindgen_malloc, wasm.__wbindgen_realloc);
+        const len0 = WASM_VECTOR_LEN;
+        const ret = wasm.find_routes(ptr0, len0, depth, max_routes, beam_width);
+        deferred2_0 = ret[0];
+        deferred2_1 = ret[1];
+        return getStringFromWasm0(ret[0], ret[1]);
+    } finally {
+        wasm.__wbindgen_free(deferred2_0, deferred2_1, 1);
+    }
+}
+
+/**
+ * Return the crate version string.
+ * @returns {string}
+ */
+export function version() {
+    let deferred1_0;
+    let deferred1_1;
+    try {
+        const ret = wasm.version();
+        deferred1_0 = ret[0];
+        deferred1_1 = ret[1];
+        return getStringFromWasm0(ret[0], ret[1]);
+    } finally {
+        wasm.__wbindgen_free(deferred1_0, deferred1_1, 1);
+    }
+}
+function __wbg_get_imports() {
+    const import0 = {
+        __proto__: null,
+        __wbindgen_init_externref_table: function() {
+            const table = wasm.__wbindgen_externrefs;
+            const offset = table.grow(4);
+            table.set(0, undefined);
+            table.set(offset + 0, undefined);
+            table.set(offset + 1, null);
+            table.set(offset + 2, true);
+            table.set(offset + 3, false);
+        },
+    };
+    return {
+        __proto__: null,
+        "./renkin_bg.js": import0,
+    };
+}
+
+function getStringFromWasm0(ptr, len) {
+    return decodeText(ptr >>> 0, len);
+}
+
+let cachedUint8ArrayMemory0 = null;
+function getUint8ArrayMemory0() {
+    if (cachedUint8ArrayMemory0 === null || cachedUint8ArrayMemory0.byteLength === 0) {
+        cachedUint8ArrayMemory0 = new Uint8Array(wasm.memory.buffer);
+    }
+    return cachedUint8ArrayMemory0;
+}
+
+function passStringToWasm0(arg, malloc, realloc) {
+    if (realloc === undefined) {
+        const buf = cachedTextEncoder.encode(arg);
+        const ptr = malloc(buf.length, 1) >>> 0;
+        getUint8ArrayMemory0().subarray(ptr, ptr + buf.length).set(buf);
+        WASM_VECTOR_LEN = buf.length;
+        return ptr;
+    }
+
+    let len = arg.length;
+    let ptr = malloc(len, 1) >>> 0;
+
+    const mem = getUint8ArrayMemory0();
+
+    let offset = 0;
+
+    for (; offset < len; offset++) {
+        const code = arg.charCodeAt(offset);
+        if (code > 0x7F) break;
+        mem[ptr + offset] = code;
+    }
+    if (offset !== len) {
+        if (offset !== 0) {
+            arg = arg.slice(offset);
+        }
+        ptr = realloc(ptr, len, len = offset + arg.length * 3, 1) >>> 0;
+        const view = getUint8ArrayMemory0().subarray(ptr + offset, ptr + len);
+        const ret = cachedTextEncoder.encodeInto(arg, view);
+
+        offset += ret.written;
+        ptr = realloc(ptr, len, offset, 1) >>> 0;
+    }
+
+    WASM_VECTOR_LEN = offset;
+    return ptr;
+}
+
+let cachedTextDecoder = new TextDecoder('utf-8', { ignoreBOM: true, fatal: true });
+cachedTextDecoder.decode();
+const MAX_SAFARI_DECODE_BYTES = 2146435072;
+let numBytesDecoded = 0;
+function decodeText(ptr, len) {
+    numBytesDecoded += len;
+    if (numBytesDecoded >= MAX_SAFARI_DECODE_BYTES) {
+        cachedTextDecoder = new TextDecoder('utf-8', { ignoreBOM: true, fatal: true });
+        cachedTextDecoder.decode();
+        numBytesDecoded = len;
+    }
+    return cachedTextDecoder.decode(getUint8ArrayMemory0().subarray(ptr, ptr + len));
+}
+
+const cachedTextEncoder = new TextEncoder();
+
+if (!('encodeInto' in cachedTextEncoder)) {
+    cachedTextEncoder.encodeInto = function (arg, view) {
+        const buf = cachedTextEncoder.encode(arg);
+        view.set(buf);
+        return {
+            read: arg.length,
+            written: buf.length
+        };
+    };
+}
+
+let WASM_VECTOR_LEN = 0;
+
+let wasmModule, wasmInstance, wasm;
+function __wbg_finalize_init(instance, module) {
+    wasmInstance = instance;
+    wasm = instance.exports;
+    wasmModule = module;
+    cachedUint8ArrayMemory0 = null;
+    wasm.__wbindgen_start();
+    return wasm;
+}
+
+async function __wbg_load(module, imports) {
+    if (typeof Response === 'function' && module instanceof Response) {
+        if (typeof WebAssembly.instantiateStreaming === 'function') {
+            try {
+                return await WebAssembly.instantiateStreaming(module, imports);
+            } catch (e) {
+                const validResponse = module.ok && expectedResponseType(module.type);
+
+                if (validResponse && module.headers.get('Content-Type') !== 'application/wasm') {
+                    console.warn("`WebAssembly.instantiateStreaming` failed because your server does not serve Wasm with `application/wasm` MIME type. Falling back to `WebAssembly.instantiate` which is slower. Original error:\n", e);
+
+                } else { throw e; }
+            }
+        }
+
+        const bytes = await module.arrayBuffer();
+        return await WebAssembly.instantiate(bytes, imports);
+    } else {
+        const instance = await WebAssembly.instantiate(module, imports);
+
+        if (instance instanceof WebAssembly.Instance) {
+            return { instance, module };
+        } else {
+            return instance;
+        }
+    }
+
+    function expectedResponseType(type) {
+        switch (type) {
+            case 'basic': case 'cors': case 'default': return true;
+        }
+        return false;
+    }
+}
+
+function initSync(module) {
+    if (wasm !== undefined) return wasm;
+
+
+    if (module !== undefined) {
+        if (Object.getPrototypeOf(module) === Object.prototype) {
+            ({module} = module)
+        } else {
+            console.warn('using deprecated parameters for `initSync()`; pass a single object instead')
+        }
+    }
+
+    const imports = __wbg_get_imports();
+    if (!(module instanceof WebAssembly.Module)) {
+        module = new WebAssembly.Module(module);
+    }
+    const instance = new WebAssembly.Instance(module, imports);
+    return __wbg_finalize_init(instance, module);
+}
+
+async function __wbg_init(module_or_path) {
+    if (wasm !== undefined) return wasm;
+
+
+    if (module_or_path !== undefined) {
+        if (Object.getPrototypeOf(module_or_path) === Object.prototype) {
+            ({module_or_path} = module_or_path)
+        } else {
+            console.warn('using deprecated parameters for the initialization function; pass a single object instead')
+        }
+    }
+
+    if (module_or_path === undefined) {
+        module_or_path = new URL('renkin_bg.wasm', import.meta.url);
+    }
+    const imports = __wbg_get_imports();
+
+    if (typeof module_or_path === 'string' || (typeof Request === 'function' && module_or_path instanceof Request) || (typeof URL === 'function' && module_or_path instanceof URL)) {
+        module_or_path = fetch(module_or_path);
+    }
+
+    const { instance, module } = await __wbg_load(await module_or_path, imports);
+
+    return __wbg_finalize_init(instance, module);
+}
+
+export { initSync, __wbg_init as default };