react-mutation-mapper 0.8.81 → 0.8.82

package/dist/component/column/Annotation.d.ts

@@ -1,12 +1,14 @@
 import { ICivicEntry, ICivicGeneIndex, ICivicVariantIndex, IHotspotIndex, IMyCancerGenomeData, IOncoKbData, MobxCache, Mutation, OncoKbCardDataType, RemoteData } from 'cbioportal-utils';
 import { CancerGene, IndicatorQueryResp } from 'oncokb-ts-api-client';
 import * as React from 'react';
+import { VariantAnnotation, Vues as VUE } from 'genome-nexus-ts-api-client';
 export declare type AnnotationProps = {
     mutation?: Mutation;
     enableOncoKb: boolean;
     enableMyCancerGenome: boolean;
     enableHotspot: boolean;
     enableCivic: boolean;
+    enableRevue: boolean;
     hotspotData?: RemoteData<IHotspotIndex | undefined>;
     oncoKbData?: RemoteData<IOncoKbData | Error | undefined>;
     oncoKbCancerGenes?: RemoteData<CancerGene[] | Error | undefined>;
@@ -19,6 +21,9 @@ export declare type AnnotationProps = {
     myCancerGenomeData?: IMyCancerGenomeData;
     civicGenes?: RemoteData<ICivicGeneIndex | undefined>;
     civicVariants?: RemoteData<ICivicVariantIndex | undefined>;
+    indexedVariantAnnotations?: RemoteData<{
+        [genomicLocation: string]: VariantAnnotation;
+    } | undefined>;
     userDisplayName?: string;
 };
 export declare type GenericAnnotationProps = {
@@ -27,6 +32,7 @@ export declare type GenericAnnotationProps = {
     enableHotspot: boolean;
     enableMyCancerGenome: boolean;
     enableOncoKb: boolean;
+    enableRevue: boolean;
     mergeOncoKbIcons?: boolean;
     oncoKbContentPadding?: number;
     pubMedCache?: MobxCache;
@@ -47,9 +53,12 @@ export interface IAnnotation {
     civicStatus: 'pending' | 'error' | 'complete';
     hasCivicVariants: boolean;
     hugoGeneSymbol: string;
+    vue?: VUE;
 }
 export declare const DEFAULT_ANNOTATION_DATA: IAnnotation;
-export declare function getAnnotationData(mutation?: Mutation, oncoKbCancerGenes?: RemoteData<CancerGene[] | Error | undefined>, hotspotData?: RemoteData<IHotspotIndex | undefined>, myCancerGenomeData?: IMyCancerGenomeData, oncoKbData?: RemoteData<IOncoKbData | Error | undefined>, usingPublicOncoKbInstance?: boolean, civicGenes?: RemoteData<ICivicGeneIndex | undefined>, civicVariants?: RemoteData<ICivicVariantIndex | undefined>, resolveTumorType?: (mutation: Mutation) => string, resolveEntrezGeneId?: (mutation: Mutation) => number): IAnnotation;
+export declare function getAnnotationData(mutation?: Mutation, oncoKbCancerGenes?: RemoteData<CancerGene[] | Error | undefined>, hotspotData?: RemoteData<IHotspotIndex | undefined>, myCancerGenomeData?: IMyCancerGenomeData, oncoKbData?: RemoteData<IOncoKbData | Error | undefined>, usingPublicOncoKbInstance?: boolean, civicGenes?: RemoteData<ICivicGeneIndex | undefined>, civicVariants?: RemoteData<ICivicVariantIndex | undefined>, indexedVariantAnnotations?: RemoteData<{
+    [genomicLocation: string]: VariantAnnotation;
+} | undefined>, resolveTumorType?: (mutation: Mutation) => string, resolveEntrezGeneId?: (mutation: Mutation) => number): IAnnotation;
 export declare function annotationSortMethod(a: IAnnotation, b: IAnnotation): number;
 export declare function sortValue(annotation: IAnnotation): number[];
 export declare function GenericAnnotation(props: GenericAnnotationProps): JSX.Element;

package/dist/component/mutationMapper/MutationMapper.d.ts

@@ -57,6 +57,7 @@ export declare type MutationMapperProps = {
     oncoKbUrl?: string;
     enableOncoKb?: boolean;
     enableCivic?: boolean;
+    enableRevue?: boolean;
     cachePostMethodsOnClients?: boolean;
     apiCacheLimit?: number;
     showTranscriptDropDown?: boolean;

package/dist/component/mutationTable/DefaultMutationTable.d.ts

@@ -20,6 +20,7 @@ export declare type DefaultMutationTableProps = {
     } | undefined>;
     selectedTranscriptId?: string;
     enableCivic?: boolean;
+    enableRevue?: boolean;
     civicGenes?: RemoteData<ICivicGeneIndex | undefined>;
     civicVariants?: RemoteData<ICivicVariantIndex | undefined>;
     pubMedCache?: MobxCache;

package/dist/component/revue/Revue.d.ts

@@ -0,0 +1,9 @@
+import React from 'react';
+import { Vues as VUE } from 'genome-nexus-ts-api-client';
+export declare const RevueTooltipContent: React.FunctionComponent<{
+    vue: VUE;
+}>;
+export declare function sortValue(vue: VUE | undefined): number;
+export declare const RevueCell: React.FunctionComponent<{
+    vue: VUE;
+}>;

package/dist/index.d.ts

@@ -14,6 +14,7 @@ export { default as Hgvsg } from './component/column/Hgvsg';
 export * from './component/column/HgvsHelper';
 export { MutationStatus } from './component/column/MutationStatus';
 export { default as ProteinChange, proteinChangeSortMethod, } from './component/column/ProteinChange';
+export { RevueCell, RevueTooltipContent } from './component/revue/Revue';
 export { default as Signal, getSignalData, getSortValue as signalSortValue, download as signalDownload, getSingleSignalValue, SignalTable, } from './component/column/Signal';
 export { default as DropdownSelector, DropdownSelectorProps, } from './component/filter/DropdownSelector';
 export { default as BadgeLabel } from './component/filter/BadgeLabel';

package/dist/index.es.js

@@ -4,9 +4,10 @@ import ___default from 'lodash';
 import { makeObservable, observable, computed, action, reaction } from 'mobx';
 import { observer } from 'mobx-react';
 import * as React from 'react';
+import React__default from 'react';
 import { DefaultTooltip, TruncatedText, getNCBIlink, cachePostMethodsOnClient, CanonicalMutationType, MutationTumorTypeFrequencyTable, FREQUENCY_COLUMNS_DEFINITION, FrequencyTableColumnEnum, CheckedSelect, getSelectedValuesMap, BadgeListSelector, MUT_COLOR_MISSENSE, MUT_COLOR_MISSENSE_PASSENGER, MUT_COLOR_INFRAME, MUT_COLOR_INFRAME_PASSENGER, MUT_COLOR_TRUNC, MUT_COLOR_TRUNC_PASSENGER, MUT_COLOR_SPLICE, MUT_COLOR_SPLICE_PASSENGER, STRUCTURAL_VARIANT_COLOR, STRUCTURAL_VARIANT_PASSENGER_COLOR, MUT_COLOR_OTHER, MUT_COLOR_OTHER_PASSENGER, getCanonicalMutationType, getProteinImpactTypeFromCanonical, ProteinImpactType, getProteinImpactType, resolveColumnVisibility, resolveColumnVisibilityByColumnDefinition, longestCommonStartingSubstring, getTextWidth, unhoverAllComponents, SVGAxis, getComponentIndex, defaultHitzoneConfig, initHitZoneFromConfig, EditableSpan, DownloadControls, EllipsisTextTooltip, remoteData, WindowWrapper } from 'cbioportal-frontend-commons';
 import classNames from 'classnames';
-import { CIVIC_NA_VALUE, parseMyCancerGenomeLink, uniqueGenomicLocations, indexAnnotationsByGenomicLocation, getCivicEntry, getRemoteDataGroupStatus, getMyCancerGenomeLinks, isLinearClusterHotspot, is3dHotspot, OncoKbCardDataType, defaultArraySortMethod, getVariantAnnotation, defaultSortMethod, getDbsnpRsId, getMyVariantInfoAnnotation, generateHgvsgByMutation, calcProteinChangeSortValue, Pathogenicity, extendMutations, formatNumberValueInSignificantDigits, generateTumorTypeDecomposition, formatPercentValue, countMutationsByProteinChange, numberOfLeadingDecimalZeros, filterLinearClusterHotspotsByMutations, filter3dHotspotsByMutations, isHotspot, defaultHotspotFilter, extractExonInformation, formatExonLocation, formatExonLength, ptmColor, compareByPtmTypePriority, UniprotTopologyTrackToColor, UniprotTopologyTypeToTitle, PtmSource, PTM_SOURCE_URL, getMyVariantInfoAnnotationsFromIndexedVariantAnnotations, getMyCancerGenomeData, genomicLocationString, convertUniprotFeatureToPtm, convertDbPtmToPtm, UniprotCategory, convertUniprotFeatureToUniprotTopology, groupPtmDataByPosition, groupPtmDataByTypeAndPosition, groupCancerHotspotDataByPosition, indexHotspotsData, fetchCivicGenes, fetchCivicVariants, getMutationsByTranscriptId, groupMutationsByProteinStartPos, groupHotspotsByMutations } from 'cbioportal-utils';
+import { CIVIC_NA_VALUE, parseMyCancerGenomeLink, uniqueGenomicLocations, indexAnnotationsByGenomicLocation, getCivicEntry, getRemoteDataGroupStatus, getMyCancerGenomeLinks, isLinearClusterHotspot, is3dHotspot, getVariantAnnotation, OncoKbCardDataType, defaultArraySortMethod, defaultSortMethod, getDbsnpRsId, getMyVariantInfoAnnotation, generateHgvsgByMutation, calcProteinChangeSortValue, Pathogenicity, extendMutations, formatNumberValueInSignificantDigits, generateTumorTypeDecomposition, formatPercentValue, countMutationsByProteinChange, numberOfLeadingDecimalZeros, filterLinearClusterHotspotsByMutations, filter3dHotspotsByMutations, isHotspot, defaultHotspotFilter, extractExonInformation, formatExonLocation, formatExonLength, ptmColor, compareByPtmTypePriority, UniprotTopologyTrackToColor, UniprotTopologyTypeToTitle, PtmSource, PTM_SOURCE_URL, getMyVariantInfoAnnotationsFromIndexedVariantAnnotations, getMyCancerGenomeData, genomicLocationString, convertUniprotFeatureToPtm, convertDbPtmToPtm, UniprotCategory, convertUniprotFeatureToUniprotTopology, groupPtmDataByPosition, groupPtmDataByTypeAndPosition, groupCancerHotspotDataByPosition, indexHotspotsData, fetchCivicGenes, fetchCivicVariants, getMutationsByTranscriptId, groupMutationsByProteinStartPos, groupHotspotsByMutations } from 'cbioportal-utils';
 import { getIndicatorData, calculateOncoKbAvailableDataType, oncoKbAnnotationSortValue, OncoKB, OncoKbSummaryTable, LEVELS, getTumorTypeNameWithExclusionInfo, ReferenceList, generateProteinChangeQuery, StructuralVariantType, generateAnnotateStructuralVariantQuery, defaultOncoKbFilter, groupOncoKbIndicatorDataByMutations, defaultOncoKbIndicatorFilter } from 'oncokb-frontend-commons';
 import { GenomeNexusAPI, GenomeNexusAPIInternal } from 'genome-nexus-ts-api-client';
 import { OncoKbAPI } from 'oncokb-ts-api-client';
@@ -150,7 +151,7 @@ function hideArrow(tooltipEl) {
     var arrowEl = tooltipEl.querySelector('.rc-tooltip-arrow');
     arrowEl.style.display = 'none';
 }
-function sortValue$7(civicEntry) {
+function sortValue$8(civicEntry) {
     var score = 0;
     if (civicEntry) {
         score = 1;
@@ -271,7 +272,7 @@ function placeArrow$1(tooltipEl) {
     var arrowEl = tooltipEl.querySelector('.rc-tooltip-arrow');
     arrowEl.style.left = '10px';
 }
-function sortValue$6(links) {
+function sortValue$7(links) {
     return links.length > 0 ? 1 : 0;
 }
 function download$5(links) {
@@ -395,7 +396,7 @@ var img$1 = "data:image/svg+xml,%3c%3fxml version='1.0' encoding='utf-8'%3f%3e%3
 
 var img = "data:image/svg+xml,%3c%3fxml version='1.0' encoding='utf-8'%3f%3e%3c!-- Generator: Adobe Illustrator 16.0.4%2c SVG Export Plug-In . SVG Version: 6.00 Build 0) --%3e%3c!DOCTYPE svg PUBLIC '-//W3C//DTD SVG 1.1//EN' 'http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd'%3e%3csvg version='1.1' id='Layer_1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink' x='0px' y='0px' width='24.263px' height='36.366px' viewBox='0 0 24.263 36.366' enable-background='new 0 0 24.263 36.366' xml:space='preserve'%3e%3cg%3e %3cpath fill='%23FF9900' d='M6.828%2c27.947c-1.859-3.872-0.869-6.094%2c0.564-8.184c1.565-2.296%2c1.968-4.558%2c1.968-4.558 s1.231%2c1.6%2c0.742%2c4.104c2.181-2.423%2c2.591-6.286%2c2.256-7.764c4.921%2c3.436%2c7.027%2c10.889%2c4.19%2c16.401 C31.627%2c19.419%2c20.3%2c6.66%2c18.326%2c5.221c0.656%2c1.439%2c0.783%2c3.873-0.546%2c5.053C15.536%2c1.75%2c9.98%2c0%2c9.98%2c0 c0.657%2c4.397-2.388%2c9.208-5.316%2c12.8C4.56%2c11.046%2c4.451%2c9.831%2c3.53%2c8.155c-0.201%2c3.183-2.636%2c5.785-3.298%2c8.974 C-0.659%2c21.445%2c0.9%2c24.61%2c6.828%2c27.947L6.828%2c27.947z'/%3e %3ctext transform='matrix(0.583 0 0 0.583 3.7324 36.1963)' fill='black' font-family='Arial-BoldItalicMT' font-size='20.6802'%3e3D%3c/text%3e%3c/g%3e%3c/svg%3e";
 
-function sortValue$5(isHotspot, is3dHotspot) {
+function sortValue$6(isHotspot, is3dHotspot) {
     var score = 0;
     if (isHotspot) {
         score += 1;
@@ -556,6 +557,42 @@ function initOncoKbClient(oncoKbUrl, cachePostMethods, apiCacheLimit) {
     return client;
 }
 
+var RevueTooltipContent = function (props) {
+    return (React__default.createElement("div", null,
+        props.vue.comment,
+        ' ',
+        React__default.createElement("a", { href: "https://pubmed.ncbi.nlm.nih.gov/" + props.vue.pubmedIds[0] + "/", rel: "noopener noreferrer", target: "_blank" },
+            "(",
+            props.vue.referenceText,
+            ")"),
+        React__default.createElement("ul", null,
+            React__default.createElement("li", null,
+                "Predicted Effect: ",
+                React__default.createElement("strong", null, props.vue.defaultEffect)),
+            React__default.createElement("li", null,
+                "Experimentally Validated Effect:",
+                ' ',
+                React__default.createElement("strong", null, props.vue.variantClassification)),
+            React__default.createElement("li", null,
+                "Revised Protein Effect:",
+                ' ',
+                React__default.createElement("strong", null, props.vue.revisedProteinEffect))),
+        React__default.createElement("div", null,
+            "Source:",
+            ' ',
+            React__default.createElement("a", { href: "https://cancerrevue.org", target: "_blank", rel: "noopener noreferrer" },
+                "reVUE ",
+                React__default.createElement("i", { className: "fa fa-external-link" })))));
+};
+function sortValue$5(vue) {
+    return vue ? 1 : 0;
+}
+var RevueCell = function (props) {
+    return (React__default.createElement(DefaultTooltip, { placement: "bottom", overlay: React__default.createElement(RevueTooltipContent, { vue: props.vue }) },
+        React__default.createElement("span", { className: "" + annotationStyles['annotation-item'], style: { display: 'inline-flex' } },
+            React__default.createElement("img", { src: '../../images/vue_logo.png', alt: "reVUE logo", width: 14, height: 14 }))));
+};
+
 var DEFAULT_ANNOTATION_DATA = {
     oncoKbStatus: 'complete',
     oncoKbGeneExist: false,
@@ -577,18 +614,15 @@ function getDefaultTumorType() {
     return '';
 }
 var memoized = new Map();
-function getAnnotationData(mutation, oncoKbCancerGenes, hotspotData, myCancerGenomeData, oncoKbData, usingPublicOncoKbInstance, civicGenes, civicVariants, resolveTumorType, resolveEntrezGeneId) {
+function getAnnotationData(mutation, oncoKbCancerGenes, hotspotData, myCancerGenomeData, oncoKbData, usingPublicOncoKbInstance, civicGenes, civicVariants, indexedVariantAnnotations, resolveTumorType, resolveEntrezGeneId) {
+    var _a;
     if (resolveTumorType === void 0) { resolveTumorType = getDefaultTumorType; }
     if (resolveEntrezGeneId === void 0) { resolveEntrezGeneId = getDefaultEntrezGeneId; }
     var value;
     if (mutation) {
         var key = '';
-        var memoize = !!oncoKbCancerGenes && (oncoKbCancerGenes === null || oncoKbCancerGenes === void 0 ? void 0 : oncoKbCancerGenes.isComplete) &&
-            !!hotspotData && (hotspotData === null || hotspotData === void 0 ? void 0 : hotspotData.isComplete) &&
-            !!myCancerGenomeData &&
-            !!oncoKbData && (oncoKbData === null || oncoKbData === void 0 ? void 0 : oncoKbData.isComplete) &&
-            !!civicGenes && (civicGenes === null || civicGenes === void 0 ? void 0 : civicGenes.isComplete) &&
-            !!civicVariants && (civicVariants === null || civicVariants === void 0 ? void 0 : civicVariants.isComplete);
+        var memoize = (oncoKbCancerGenes === null || oncoKbCancerGenes === void 0 ? void 0 : oncoKbCancerGenes.isComplete) && (hotspotData === null || hotspotData === void 0 ? void 0 : hotspotData.isComplete) &&
+            !!myCancerGenomeData && (oncoKbData === null || oncoKbData === void 0 ? void 0 : oncoKbData.isComplete) && (civicGenes === null || civicGenes === void 0 ? void 0 : civicGenes.isComplete) && (civicVariants === null || civicVariants === void 0 ? void 0 : civicVariants.isComplete) && (indexedVariantAnnotations === null || indexedVariantAnnotations === void 0 ? void 0 : indexedVariantAnnotations.isComplete);
         if (memoize) {
             key = JSON.stringify(mutation) + !!usingPublicOncoKbInstance;
             var val = memoized.get(key);
@@ -638,17 +672,16 @@ function getAnnotationData(mutation, oncoKbCancerGenes, hotspotData, myCancerGen
             myCancerGenomeLinks: myCancerGenomeData
                 ? getMyCancerGenomeLinks(mutation, myCancerGenomeData)
                 : [],
-            isHotspot: hotspotData &&
-                hotspotData.result &&
-                hotspotData.status === 'complete'
+            isHotspot: (hotspotData === null || hotspotData === void 0 ? void 0 : hotspotData.isComplete) && hotspotData.result
                 ? isLinearClusterHotspot(mutation, hotspotData.result)
                 : false,
-            is3dHotspot: hotspotData &&
-                hotspotData.result &&
-                hotspotData.status === 'complete'
+            is3dHotspot: (hotspotData === null || hotspotData === void 0 ? void 0 : hotspotData.isComplete) && hotspotData.result
                 ? is3dHotspot(mutation, hotspotData.result)
                 : false,
             hotspotStatus: hotspotData ? hotspotData.status : 'pending',
+            vue: (indexedVariantAnnotations === null || indexedVariantAnnotations === void 0 ? void 0 : indexedVariantAnnotations.isComplete) &&
+                indexedVariantAnnotations.result
+                ? (_a = getVariantAnnotation(mutation, indexedVariantAnnotations.result)) === null || _a === void 0 ? void 0 : _a.annotation_summary.vues : undefined,
         };
         // oncoKbData may exist but it might be an instance of Error, in that case we flag the status as error
         if (oncoKbData && oncoKbData.result instanceof Error) {
@@ -693,16 +726,18 @@ function annotationSortMethod(a, b) {
 function sortValue$4(annotation) {
     return ___default.flatten([
         oncoKbAnnotationSortValue(annotation.oncoKbIndicator),
-        sortValue$7(annotation.civicEntry),
-        sortValue$6(annotation.myCancerGenomeLinks),
-        sortValue$5(annotation.isHotspot, annotation.is3dHotspot),
+        sortValue$8(annotation.civicEntry),
+        sortValue$7(annotation.myCancerGenomeLinks),
+        sortValue$6(annotation.isHotspot, annotation.is3dHotspot),
+        sortValue$5(annotation.vue),
         annotation.isOncoKbCancerGene ? 1 : 0,
     ]);
 }
 function GenericAnnotation(props) {
-    var annotation = props.annotation, enableCivic = props.enableCivic, enableHotspot = props.enableHotspot, enableMyCancerGenome = props.enableMyCancerGenome, enableOncoKb = props.enableOncoKb; props.pubMedCache; var userDisplayName = props.userDisplayName, mergeOncoKbIcons = props.mergeOncoKbIcons, oncoKbContentPadding = props.oncoKbContentPadding;
+    var annotation = props.annotation, enableCivic = props.enableCivic, enableHotspot = props.enableHotspot, enableMyCancerGenome = props.enableMyCancerGenome, enableOncoKb = props.enableOncoKb, enableRevue = props.enableRevue; props.pubMedCache; var userDisplayName = props.userDisplayName, mergeOncoKbIcons = props.mergeOncoKbIcons, oncoKbContentPadding = props.oncoKbContentPadding;
     return (React.createElement("span", { style: { display: 'flex', minWidth: 100 } },
         enableOncoKb && (React.createElement(OncoKB, { usingPublicOncoKbInstance: annotation.usingPublicOncoKbInstance, hugoGeneSymbol: annotation.hugoGeneSymbol, geneNotExist: !annotation.oncoKbGeneExist, isCancerGene: annotation.isOncoKbCancerGene, status: annotation.oncoKbStatus, indicator: annotation.oncoKbIndicator, availableDataTypes: annotation.oncoKbAvailableDataTypes, mergeAnnotationIcons: mergeOncoKbIcons, userDisplayName: userDisplayName, contentPadding: oncoKbContentPadding })),
+        enableRevue && annotation.vue ? (React.createElement(RevueCell, { vue: annotation.vue })) : (React.createElement("span", { className: "" + annotationStyles['annotation-item'] })),
         enableCivic && (React.createElement(Civic, { civicEntry: annotation.civicEntry, civicStatus: annotation.civicStatus, hasCivicVariants: annotation.hasCivicVariants })),
         enableMyCancerGenome && (React.createElement(MyCancerGenome, { linksHTML: annotation.myCancerGenomeLinks })),
         enableHotspot && (React.createElement(HotspotAnnotation, { isHotspot: annotation.isHotspot, is3dHotspot: annotation.is3dHotspot, status: annotation.hotspotStatus }))));
@@ -726,8 +761,8 @@ var Annotation = /** @class */ (function (_super) {
         configurable: true,
         writable: true,
         value: function (props) {
-            var mutation = props.mutation, oncoKbCancerGenes = props.oncoKbCancerGenes, hotspotData = props.hotspotData, myCancerGenomeData = props.myCancerGenomeData, oncoKbData = props.oncoKbData, usingPublicOncoKbInstance = props.usingPublicOncoKbInstance, resolveEntrezGeneId = props.resolveEntrezGeneId, resolveTumorType = props.resolveTumorType, civicGenes = props.civicGenes, civicVariants = props.civicVariants;
-            return getAnnotationData(mutation, oncoKbCancerGenes, hotspotData, myCancerGenomeData, oncoKbData, usingPublicOncoKbInstance, civicGenes, civicVariants, resolveTumorType, resolveEntrezGeneId);
+            var mutation = props.mutation, oncoKbCancerGenes = props.oncoKbCancerGenes, hotspotData = props.hotspotData, myCancerGenomeData = props.myCancerGenomeData, oncoKbData = props.oncoKbData, usingPublicOncoKbInstance = props.usingPublicOncoKbInstance, resolveEntrezGeneId = props.resolveEntrezGeneId, resolveTumorType = props.resolveTumorType, civicGenes = props.civicGenes, civicVariants = props.civicVariants, indexedVariantAnnotations = props.indexedVariantAnnotations;
+            return getAnnotationData(mutation, oncoKbCancerGenes, hotspotData, myCancerGenomeData, oncoKbData, usingPublicOncoKbInstance, civicGenes, civicVariants, indexedVariantAnnotations, resolveTumorType, resolveEntrezGeneId);
         }
     });
     Annotation = __decorate([
@@ -3621,7 +3656,7 @@ var DefaultMutationTable = /** @class */ (function (_super) {
             return this.annotationColumnDataStatus === 'pending'
                 ? function () { return undefined; }
                 : function (mutation) {
-                    return getAnnotationData(mutation, _this.props.oncoKbCancerGenes, _this.props.hotspotData, _this.props.myCancerGenomeData, _this.props.oncoKbData, _this.props.usingPublicOncoKbInstance, _this.props.civicGenes, _this.props.civicVariants);
+                    return getAnnotationData(mutation, _this.props.oncoKbCancerGenes, _this.props.hotspotData, _this.props.myCancerGenomeData, _this.props.oncoKbData, _this.props.usingPublicOncoKbInstance, _this.props.civicGenes, _this.props.civicVariants, _this.props.indexedVariantAnnotations);
                 };
         },
         enumerable: false,
@@ -3724,7 +3759,7 @@ var DefaultMutationTable = /** @class */ (function (_super) {
             var _this = this;
             switch (columnKey) {
                 case MutationColumn.ANNOTATION:
-                    return function (column) { return (React.createElement(Annotation, { mutation: column.original, enableOncoKb: true, enableHotspot: true, enableCivic: _this.props.enableCivic || false, enableMyCancerGenome: true, hotspotData: _this.props.hotspotData, oncoKbData: _this.props.oncoKbData, oncoKbCancerGenes: _this.props.oncoKbCancerGenes, usingPublicOncoKbInstance: _this.props.usingPublicOncoKbInstance, pubMedCache: _this.props.pubMedCache, civicGenes: _this.props.civicGenes, civicVariants: _this.props.civicVariants })); };
+                    return function (column) { return (React.createElement(Annotation, { mutation: column.original, enableOncoKb: true, enableHotspot: true, enableCivic: _this.props.enableCivic || false, enableMyCancerGenome: true, enableRevue: true, hotspotData: _this.props.hotspotData, oncoKbData: _this.props.oncoKbData, oncoKbCancerGenes: _this.props.oncoKbCancerGenes, usingPublicOncoKbInstance: _this.props.usingPublicOncoKbInstance, pubMedCache: _this.props.pubMedCache, civicGenes: _this.props.civicGenes, civicVariants: _this.props.civicVariants, indexedVariantAnnotations: _this.props.indexedVariantAnnotations })); };
                 case MutationColumn.HGVSG:
                     return function (column) { return React.createElement(Hgvsg, { mutation: column.original }); };
                 case MutationColumn.HGVSC:
@@ -10979,6 +11014,7 @@ function initDefaultMutationMapperStore(props) {
         oncoKbUrl: props.oncoKbUrl,
         enableCivic: props.enableCivic,
         enableOncoKb: props.enableOncoKb,
+        enableRevue: props.enableRevue,
         cachePostMethodsOnClients: props.cachePostMethodsOnClients,
         apiCacheLimit: props.apiCacheLimit,
         getMutationCount: props.getMutationCount,
@@ -11186,7 +11222,7 @@ var MutationMapper = /** @class */ (function (_super) {
                 if (this.props.mutationTableColumns) {
                     columns = this.props.mutationTableColumns;
                 }
-                return (React.createElement(DefaultMutationTable, { dataStore: this.store.dataStore, columns: columns, initialSort: this.props.mutationTableInitialSort, initialSortRemoteData: this.props.mutationTableInitialSortRemoteData, reactTableProps: this.props.customMutationTableProps, hotspotData: this.store.indexedHotspotData, oncoKbData: this.store.oncoKbData, usingPublicOncoKbInstance: this.store.usingPublicOncoKbInstance, oncoKbCancerGenes: this.store.oncoKbCancerGenes, myCancerGenomeData: this.store.myCancerGenomeData, enableCivic: this.props.enableCivic, civicGenes: this.store.civicGenes, civicVariants: this.store.civicVariants, indexedMyVariantInfoAnnotations: this.store.indexedMyVariantInfoAnnotations, indexedVariantAnnotations: this.store.indexedVariantAnnotations, selectedTranscriptId: this.store.selectedTranscript, pubMedCache: this.pubMedCache, info: this.mutationTableInfo }));
+                return (React.createElement(DefaultMutationTable, { dataStore: this.store.dataStore, columns: columns, initialSort: this.props.mutationTableInitialSort, initialSortRemoteData: this.props.mutationTableInitialSortRemoteData, reactTableProps: this.props.customMutationTableProps, hotspotData: this.store.indexedHotspotData, oncoKbData: this.store.oncoKbData, usingPublicOncoKbInstance: this.store.usingPublicOncoKbInstance, oncoKbCancerGenes: this.store.oncoKbCancerGenes, myCancerGenomeData: this.store.myCancerGenomeData, enableCivic: this.props.enableCivic, enableRevue: this.props.enableRevue, civicGenes: this.store.civicGenes, civicVariants: this.store.civicVariants, indexedMyVariantInfoAnnotations: this.store.indexedMyVariantInfoAnnotations, indexedVariantAnnotations: this.store.indexedVariantAnnotations, selectedTranscriptId: this.store.selectedTranscript, pubMedCache: this.pubMedCache, info: this.mutationTableInfo }));
             }
         },
         enumerable: false,
@@ -11388,6 +11424,7 @@ var MutationMapper = /** @class */ (function (_super) {
             showTranscriptDropDown: false,
             enableCivic: true,
             enableOncoKb: true,
+            enableRevue: true,
             filterMutationsBySelectedTranscript: false,
             cachePostMethodsOnClients: true,
         }
@@ -11425,5 +11462,5 @@ var MutationMapper = /** @class */ (function (_super) {
     return MutationMapper;
 }(React.Component));
 
-export { Annotation, AxisScale, AxisScaleSwitch, BadgeLabel, BadgeSelector, Civic, ClinvarInterpretation, ClinvarSummary, ColumnHeader, ColumnSelector, ColumnSortDirection, DEFAULT_ANNOTATION_DATA, DEFAULT_GENOME_NEXUS_URL, DEFAULT_MUTATION_ALIGNER_PROXY_URL_TEMPLATE, DEFAULT_MUTATION_ALIGNER_URL_TEMPLATE, DEFAULT_MUTATION_COLUMNS, DEFAULT_MY_GENE_URL_TEMPLATE, DEFAULT_ONCO_KB_URL, DEFAULT_PROTEIN_IMPACT_TYPE_COLORS, DEFAULT_UNIPROT_ID_URL_TEMPLATE, DataFilterType, DataTable, Dbsnp, DbsnpId, DefaultMutationMapperDataFetcher, DefaultMutationMapperDataStore, DefaultMutationMapperFilterApplier, DefaultMutationMapperStore, DefaultMutationTable, Domain, DropdownSelector, FilterResetPanel, GenericAnnotation, Gnomad, GnomadFrequency, GnomadFrequencyBreakdown, GnomadFrequencyTable, GnomadFrequencyValue, Hgvsc, Hgvsg, HotspotAnnotation, HotspotInfo, Lollipop, LollipopMutationPlot, LollipopPlot, LollipopPlotNoTooltip, LollipopTooltipCountInfo, MUTATION_COLUMNS_DEFINITION, MUTATION_COLUMN_HEADERS, MUTATION_STATUS_BADGE_STYLE_OVERRIDE, MUTATION_TYPE_PRIORITY, MutationColumn, MutationColumnName, MutationMapper, MutationStatus, MutationStatusBadgeSelector, MyCancerGenome, ONCOKB_DEFAULT_DATA, ONCOKB_DEFAULT_INFO, PercentToggle, ProteinChange, ProteinImpactTypeBadgeSelector, ProteinImpactTypeDropdownSelector, LollipopPlot as Sequence, Signal, SignalTable, TEXT_INPUT_FILTER_ID, TrackName, TrackSelector, USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, sortValue$4 as annotationSortValue, applyDataFilters, applyDataFiltersOnDatum, applyDefaultMutationFilter, applyDefaultMutationStatusFilter, applyDefaultPositionFilter, applyDefaultProteinImpactTypeFilter, calculateGnomadAlleleFrequency, download$6 as civicDownload, sortValue$7 as civicSortValue, download$4 as clinvarDownload, sortValue$3 as clinvarSortValue, download$3 as dbsnpDownload, sortValue$2 as dbsnpSortValue, fetchVariantAnnotationsByMutation, fetchVariantAnnotationsIndexedByGenomicLocation, findAllUniquePositions, findNonTextInputFilters, findOneMutationFilterValue, findTextInputFilter, getAllOptionValues, getAnnotationData, getClinvarData, getColorForProteinImpactType, getGnomadData, getHgvscColumnData, getHgvsgColumnData, getProteinImpactTypeBadgeLabel, getProteinImpactTypeOptionLabel, getSelectedOptionValues, getSignalData, getSingleSignalValue, getUrl, download$2 as gnomadDownload, sortValue$1 as gnomadSortValue, groupDataByGroupFilters, groupDataByProteinImpactType, handleOptionSelect, download$1 as hgvscDownload, sortValue as hgvscSortValue, sortValue$5 as hotspotAnnotationSortValue, includesSearchTextIgnoreCase, indexPositions, initDefaultMutationMapperStore, initDefaultTrackVisibility, initGenomeNexusClient, initGenomeNexusInternalClient, initOncoKbClient, mergeColumns, mutationTypeSort, download$5 as myCancerGenomeDownload, sortValue$6 as myCancerGenomeSortValue, onFilterOptionSelect, proteinChangeSortMethod, rightAlignedCell, download as signalDownload, getSortValue as signalSortValue, updatePositionHighlightFilters, updatePositionRangeHighlightFilters, updatePositionSelectionFilters };
+export { Annotation, AxisScale, AxisScaleSwitch, BadgeLabel, BadgeSelector, Civic, ClinvarInterpretation, ClinvarSummary, ColumnHeader, ColumnSelector, ColumnSortDirection, DEFAULT_ANNOTATION_DATA, DEFAULT_GENOME_NEXUS_URL, DEFAULT_MUTATION_ALIGNER_PROXY_URL_TEMPLATE, DEFAULT_MUTATION_ALIGNER_URL_TEMPLATE, DEFAULT_MUTATION_COLUMNS, DEFAULT_MY_GENE_URL_TEMPLATE, DEFAULT_ONCO_KB_URL, DEFAULT_PROTEIN_IMPACT_TYPE_COLORS, DEFAULT_UNIPROT_ID_URL_TEMPLATE, DataFilterType, DataTable, Dbsnp, DbsnpId, DefaultMutationMapperDataFetcher, DefaultMutationMapperDataStore, DefaultMutationMapperFilterApplier, DefaultMutationMapperStore, DefaultMutationTable, Domain, DropdownSelector, FilterResetPanel, GenericAnnotation, Gnomad, GnomadFrequency, GnomadFrequencyBreakdown, GnomadFrequencyTable, GnomadFrequencyValue, Hgvsc, Hgvsg, HotspotAnnotation, HotspotInfo, Lollipop, LollipopMutationPlot, LollipopPlot, LollipopPlotNoTooltip, LollipopTooltipCountInfo, MUTATION_COLUMNS_DEFINITION, MUTATION_COLUMN_HEADERS, MUTATION_STATUS_BADGE_STYLE_OVERRIDE, MUTATION_TYPE_PRIORITY, MutationColumn, MutationColumnName, MutationMapper, MutationStatus, MutationStatusBadgeSelector, MyCancerGenome, ONCOKB_DEFAULT_DATA, ONCOKB_DEFAULT_INFO, PercentToggle, ProteinChange, ProteinImpactTypeBadgeSelector, ProteinImpactTypeDropdownSelector, RevueCell, RevueTooltipContent, LollipopPlot as Sequence, Signal, SignalTable, TEXT_INPUT_FILTER_ID, TrackName, TrackSelector, USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, sortValue$4 as annotationSortValue, applyDataFilters, applyDataFiltersOnDatum, applyDefaultMutationFilter, applyDefaultMutationStatusFilter, applyDefaultPositionFilter, applyDefaultProteinImpactTypeFilter, calculateGnomadAlleleFrequency, download$6 as civicDownload, sortValue$8 as civicSortValue, download$4 as clinvarDownload, sortValue$3 as clinvarSortValue, download$3 as dbsnpDownload, sortValue$2 as dbsnpSortValue, fetchVariantAnnotationsByMutation, fetchVariantAnnotationsIndexedByGenomicLocation, findAllUniquePositions, findNonTextInputFilters, findOneMutationFilterValue, findTextInputFilter, getAllOptionValues, getAnnotationData, getClinvarData, getColorForProteinImpactType, getGnomadData, getHgvscColumnData, getHgvsgColumnData, getProteinImpactTypeBadgeLabel, getProteinImpactTypeOptionLabel, getSelectedOptionValues, getSignalData, getSingleSignalValue, getUrl, download$2 as gnomadDownload, sortValue$1 as gnomadSortValue, groupDataByGroupFilters, groupDataByProteinImpactType, handleOptionSelect, download$1 as hgvscDownload, sortValue as hgvscSortValue, sortValue$6 as hotspotAnnotationSortValue, includesSearchTextIgnoreCase, indexPositions, initDefaultMutationMapperStore, initDefaultTrackVisibility, initGenomeNexusClient, initGenomeNexusInternalClient, initOncoKbClient, mergeColumns, mutationTypeSort, download$5 as myCancerGenomeDownload, sortValue$7 as myCancerGenomeSortValue, onFilterOptionSelect, proteinChangeSortMethod, rightAlignedCell, download as signalDownload, getSortValue as signalSortValue, updatePositionHighlightFilters, updatePositionRangeHighlightFilters, updatePositionSelectionFilters };
 //# sourceMappingURL=index.es.js.map