jbrowse-plugin-protein3d 0.0.2 → 0.0.4

package/dist/LaunchProteinView/components/AlphaFoldDBSearch.js

@@ -1,25 +1,26 @@
 import React, { useEffect, useState } from 'react';
 import { observer } from 'mobx-react';
-import { Button, DialogActions, DialogContent } from '@mui/material';
+import { Button, DialogActions, DialogContent, Typography } from '@mui/material';
 import { makeStyles } from 'tss-react/mui';
-import { getContainingView, getSession, } from '@jbrowse/core/util';
+import { getContainingView, getSession, isSessionWithAddTracks, } from '@jbrowse/core/util';
 import { ErrorMessage, LoadingEllipses } from '@jbrowse/core/ui';
 // locals
-import { getDisplayName, getGeneDisplayName, getId, getTranscriptDisplayName, getTranscriptFeatures, } from '../util';
+import { getDisplayName, getGeneDisplayName, getId, getTranscriptDisplayName, getTranscriptFeatures, } from './util';
+// components
 import TranscriptSelector from './TranscriptSelector';
 import HelpButton from './HelpButton';
-// hooks
-import useMyGeneInfo from '../useMyGeneInfo';
-import useAllSequences from '../useProteinSequences';
-import { useCheckAlphaFoldDBExistence } from './useCheckAlphaFoldDBExistence';
 import AlphaFoldDBSearchStatus from './AlphaFoldDBSearchStatus';
+// hooks
+import useMyGeneInfoUniprotIdLookup from './useMyGeneInfoUniprotIdLookup';
+import useRemoteStructureFileSequence from './useRemoteStructureFileSequence';
+import useIsoformProteinSequences from './useIsoformProteinSequences';
 const useStyles = makeStyles()(theme => ({
     dialogContent: {
         marginTop: theme.spacing(6),
         width: '80em',
     },
 }));
-const AlphaFoldDBSearch = observer(function AlphaFoldDBSearch({ feature, model, handleClose, }) {
+const AlphaFoldDBSearch = observer(function ({ feature, model, handleClose, }) {
     const { classes } = useStyles();
     const session = getSession(model);
     // check if we are looking at a 'two-level' or 'three-level' feature by
@@ -28,44 +29,210 @@ const AlphaFoldDBSearch = observer(function AlphaFoldDBSearch({ feature, model,
     const [userSelection, setUserSelection] = useState();
     const view = getContainingView(model);
     const selectedTranscript = options.find(val => getId(val) === userSelection);
-    const { seqs, error: error2 } = useAllSequences({ feature, view });
-    const protein = seqs?.[userSelection ?? ''];
-    const { result: foundStructureId, error } = useMyGeneInfo({
-        id: selectedTranscript ? getDisplayName(selectedTranscript) : '',
+    const { isoformSequences, isLoading: isIsoformProteinSequencesLoading, error: isoformProteinSequencesError, } = useIsoformProteinSequences({
+        feature,
+        view,
+    });
+    const userSelectedProteinSequence = isoformSequences?.[userSelection ?? ''];
+    const { uniprotId, isLoading: isMyGeneLoading, error: myGeneError, } = useMyGeneInfoUniprotIdLookup({
+        id: selectedTranscript
+            ? getDisplayName(selectedTranscript)
+            : getDisplayName(feature),
     });
+    const url = uniprotId
+        ? `https://alphafold.ebi.ac.uk/files/AF-${uniprotId}-F1-model_v4.cif`
+        : undefined;
+    const { sequences: structureSequences, isLoading: isRemoteStructureSequenceLoading, error: remoteStructureSequenceError, } = useRemoteStructureFileSequence({ url });
+    const e = myGeneError || isoformProteinSequencesError || remoteStructureSequenceError;
+    const structureSequence = structureSequences?.[0];
     useEffect(() => {
-        if (userSelection === undefined && seqs !== undefined) {
-            setUserSelection(options.find(f => !!seqs[f.id()])?.id());
+        if (isoformSequences !== undefined) {
+            const ret = options.find(f => isoformSequences[f.id()]?.seq.replaceAll('*', '') ==
+                structureSequence) ?? options.find(f => !!isoformSequences[f.id()]);
+            setUserSelection(ret?.id());
         }
-    }, [options, userSelection, seqs]);
-    const { success, loading, error: error3, } = useCheckAlphaFoldDBExistence({
-        foundStructureId,
-    });
-    const e = error || error2 || error3;
-    const url = `https://alphafold.ebi.ac.uk/files/AF-${foundStructureId}-F1-model_v4.cif`;
+    }, [options, structureSequence, isoformSequences]);
     return (React.createElement(React.Fragment, null,
         React.createElement(DialogContent, { className: classes.dialogContent },
             e ? React.createElement(ErrorMessage, { error: e }) : null,
-            React.createElement("div", null,
-                "Look up AlphaFoldDB structure for given transcript ",
+            React.createElement(Typography, null,
+                "Automatically find AlphaFoldDB entry for given transcript",
+                ' ',
                 React.createElement(HelpButton, null)),
-            seqs ? (React.createElement(React.Fragment, null,
-                React.createElement(TranscriptSelector, { val: userSelection ?? '', setVal: setUserSelection, options: options, feature: feature, seqs: seqs }),
-                selectedTranscript ? (React.createElement(AlphaFoldDBSearchStatus, { foundStructureId: foundStructureId, selectedTranscript: selectedTranscript, success: success, loading: loading })) : null)) : (React.createElement("div", { style: { margin: 20 } },
-                React.createElement(LoadingEllipses, { message: "Loading protein sequences", variant: "h6" })))),
+            isRemoteStructureSequenceLoading ? (React.createElement(LoadingEllipses, { variant: "h6", message: "Loading sequence from remote structure file" })) : null,
+            isMyGeneLoading ? (React.createElement(LoadingEllipses, { variant: "h6", message: "Looking up UniProt ID from mygene.info" })) : uniprotId ? null : (React.createElement("div", null,
+                "UniProt ID not found. Search sequence on AlphaFoldDB",
+                ' ',
+                React.createElement("a", { href: `https://alphafold.ebi.ac.uk/search/sequence/${userSelectedProteinSequence?.seq.replaceAll('*', '')}`, target: "_blank", rel: "noreferrer" }, "here"),
+                ' ',
+                React.createElement("br", null),
+                "After visiting the above link, then paste the structure URL into the Manual tab")),
+            isIsoformProteinSequencesLoading ? (React.createElement(LoadingEllipses, { variant: "h6", message: "Loading protein sequences from transcript isoforms" })) : null,
+            isoformSequences && structureSequence && selectedTranscript ? (React.createElement(React.Fragment, null,
+                React.createElement(TranscriptSelector, { val: userSelection ?? '', setVal: setUserSelection, structureSequence: structureSequence, feature: feature, isoforms: options, isoformSequences: isoformSequences }),
+                React.createElement(AlphaFoldDBSearchStatus, { uniprotId: uniprotId, selectedTranscript: selectedTranscript, structureSequence: structureSequence, isoformSequences: isoformSequences }))) : null),
         React.createElement(DialogActions, null,
-            React.createElement(Button, { variant: "contained", color: "secondary", onClick: () => handleClose() }, "Cancel"),
-            React.createElement(Button, { variant: "contained", color: "primary", disabled: !foundStructureId || !protein || !selectedTranscript, onClick: () => {
+            React.createElement(Button, { variant: "contained", color: "secondary", onClick: () => {
+                    handleClose();
+                } }, "Cancel"),
+            React.createElement(Button, { variant: "contained", color: "primary", disabled: !uniprotId || !userSelectedProteinSequence || !selectedTranscript, onClick: () => {
                     session.addView('ProteinView', {
                         type: 'ProteinView',
-                        url,
-                        seq2: protein,
-                        feature: selectedTranscript?.toJSON(),
-                        connectedViewId: view.id,
-                        displayName: `Protein view ${getGeneDisplayName(feature)} - ${getTranscriptDisplayName(selectedTranscript)}`,
+                        isFloating: true,
+                        structures: [
+                            {
+                                url,
+                                userProvidedTranscriptSequence: userSelectedProteinSequence?.seq,
+                                feature: selectedTranscript?.toJSON(),
+                                connectedViewId: view.id,
+                            },
+                        ],
+                        displayName: [
+                            'Protein view',
+                            uniprotId,
+                            getGeneDisplayName(feature),
+                            getTranscriptDisplayName(selectedTranscript),
+                        ].join(' - '),
                     });
                     handleClose();
-                } }, "Submit"))));
+                } }, "Launch 3-D protein structure view"),
+            React.createElement(Button, { variant: "contained", disabled: !uniprotId || !userSelectedProteinSequence || !selectedTranscript, onClick: () => {
+                    if (uniprotId && isSessionWithAddTracks(session)) {
+                        // eslint-disable-next-line @typescript-eslint/no-floating-promises
+                        ;
+                        (async () => {
+                            try {
+                                session.addTemporaryAssembly?.({
+                                    name: uniprotId,
+                                    sequence: {
+                                        type: 'ReferenceSequenceTrack',
+                                        trackId: `${uniprotId}-ReferenceSequenceTrack`,
+                                        sequenceType: 'pep',
+                                        adapter: {
+                                            type: 'UnindexedFastaAdapter',
+                                            rewriteRefNames: "jexl:split(refName,'|')[1]",
+                                            fastaLocation: {
+                                                uri: `https://rest.uniprot.org/uniprotkb/${uniprotId}.fasta`,
+                                            },
+                                        },
+                                    },
+                                });
+                                const url = `https://rest.uniprot.org/uniprotkb/${uniprotId}.gff`;
+                                const res = await fetch(url);
+                                if (!res.ok) {
+                                    throw new Error(`HTTP ${res.status} fetching ${url}`);
+                                }
+                                const data = await res.text();
+                                const types = [
+                                    ...new Set(data
+                                        .split('\n')
+                                        .filter(f => !f.startsWith('#'))
+                                        .map(f => f.trim())
+                                        .filter(f => !!f)
+                                        .map(f => f.split('\t')[2])),
+                                ];
+                                types.forEach(type => {
+                                    const s = `${uniprotId}-${type}`;
+                                    session.addTrackConf({
+                                        type: 'FeatureTrack',
+                                        trackId: s,
+                                        name: type,
+                                        adapter: {
+                                            type: 'Gff3Adapter',
+                                            gffLocation: {
+                                                uri: `https://rest.uniprot.org/uniprotkb/${uniprotId}.gff`,
+                                            },
+                                        },
+                                        assemblyNames: [uniprotId],
+                                        displays: [
+                                            {
+                                                displayId: `${type}-LinearBasicDisplay`,
+                                                type: 'LinearBasicDisplay',
+                                                jexlFilters: [`get(feature,'type')=='${type}'`],
+                                            },
+                                        ],
+                                    });
+                                });
+                                session.addTrackConf({
+                                    type: 'FeatureTrack',
+                                    trackId: 'Antigen',
+                                    name: 'Antigen',
+                                    adapter: {
+                                        type: 'Gff3Adapter',
+                                        gffLocation: {
+                                            uri: `https://www.ebi.ac.uk/proteins/api/antigen/${uniprotId}?format=gff`,
+                                        },
+                                    },
+                                    assemblyNames: [uniprotId],
+                                });
+                                session.addTrackConf({
+                                    type: 'FeatureTrack',
+                                    trackId: 'Variation',
+                                    name: 'Variation',
+                                    adapter: {
+                                        type: 'UniProtVariationAdapter',
+                                        location: {
+                                            uri: `https://www.ebi.ac.uk/proteins/api/variation/${uniprotId}.json`,
+                                        },
+                                    },
+                                    assemblyNames: [uniprotId],
+                                });
+                                session.addTrackConf({
+                                    type: 'QuantitativeTrack',
+                                    trackId: 'AlphaFold confidence',
+                                    name: 'AlphaFold confidence',
+                                    adapter: {
+                                        type: 'AlphaFoldConfidenceAdapter',
+                                        location: {
+                                            uri: `https://alphafold.ebi.ac.uk/files/AF-${uniprotId}-F1-confidence_v4.json`,
+                                        },
+                                    },
+                                    assemblyNames: [uniprotId],
+                                });
+                                session.addTrackConf({
+                                    type: 'MultiQuantitativeTrack',
+                                    trackId: 'AlphaMissense scores',
+                                    name: 'AlphaMissense scores',
+                                    assemblyNames: [uniprotId],
+                                    adapter: {
+                                        type: 'AlphaMissensePathogenicityAdapter',
+                                        location: {
+                                            uri: `https://alphafold.ebi.ac.uk/files/AF-${uniprotId}-F1-aa-substitutions.csv`,
+                                        },
+                                    },
+                                    displays: [
+                                        {
+                                            type: 'MultiLinearWiggleDisplay',
+                                            displayId: 'AlphaMissense scores-MultiLinearWiggleDisplay',
+                                            defaultRendering: 'multirowdensity',
+                                            renderers: {
+                                                MultiDensityRenderer: {
+                                                    type: 'MultiDensityRenderer',
+                                                    bicolorPivotValue: 0.5,
+                                                },
+                                            },
+                                        },
+                                    ],
+                                });
+                                const view = session.addView('LinearGenomeView', {
+                                    type: 'LinearGenomeView',
+                                    displayName: [
+                                        'Protein view',
+                                        uniprotId,
+                                        getGeneDisplayName(feature),
+                                        getTranscriptDisplayName(selectedTranscript),
+                                    ].join(' - '),
+                                });
+                                await view.navToLocString(uniprotId, uniprotId);
+                            }
+                            catch (e) {
+                                console.error(e);
+                                session.notifyError(`${e}`, e);
+                            }
+                        })();
+                    }
+                    handleClose();
+                } }, "Launch linear protein annotation view"))));
 });
 export default AlphaFoldDBSearch;
 //# sourceMappingURL=AlphaFoldDBSearch.js.map

package/dist/LaunchProteinView/components/AlphaFoldDBSearch.js.map

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package/dist/LaunchProteinView/components/AlphaFoldDBSearchStatus.d.ts

@@ -1,8 +1,11 @@
 import React from 'react';
 import { Feature } from '@jbrowse/core/util';
-export default function AlphaFoldDBSearchStatus({ foundStructureId, selectedTranscript, success, loading, }: {
-    foundStructureId?: string;
+export default function AlphaFoldDBSearchStatus({ uniprotId, selectedTranscript, structureSequence, isoformSequences, }: {
+    uniprotId?: string;
     selectedTranscript: Feature;
-    success: boolean;
-    loading: boolean;
+    structureSequence?: string;
+    isoformSequences: Record<string, {
+        feature: Feature;
+        seq: string;
+    }>;
 }): React.JSX.Element;

package/dist/LaunchProteinView/components/AlphaFoldDBSearchStatus.js

@@ -1,19 +1,40 @@
-import React from 'react';
-import { Link, Typography } from '@mui/material';
-import { LoadingEllipses } from '@jbrowse/core/ui';
+import React, { useState } from 'react';
+import { Button, Link, Typography } from '@mui/material';
 // locals
-import { getDisplayName } from '../util';
-export default function AlphaFoldDBSearchStatus({ foundStructureId, selectedTranscript, success, loading, }) {
-    return !foundStructureId ? (React.createElement(Typography, null,
-        "Searching ",
-        getDisplayName(selectedTranscript),
-        " for UniProt ID")) : (React.createElement(React.Fragment, null,
+import { getDisplayName } from './util';
+import MSATable from './MSATable';
+function NotFound({ uniprotId }) {
+    return (React.createElement(Typography, null,
+        "No structure found for this UniProtID in AlphaFoldDB",
+        ' ',
+        React.createElement(Link, { target: "_blank", href: `https://alphafold.ebi.ac.uk/search/text/${uniprotId}` }, "(search for results)")));
+}
+export default function AlphaFoldDBSearchStatus({ uniprotId, selectedTranscript, structureSequence, isoformSequences, }) {
+    const url = uniprotId
+        ? `https://alphafold.ebi.ac.uk/files/AF-${uniprotId}-F1-model_v4.cif`
+        : undefined;
+    const url2 = uniprotId
+        ? `https://www.uniprot.org/uniprotkb/${uniprotId}/entry`
+        : undefined;
+    const [showAllProteinSequences, setShowAllProteinSequences] = useState(false);
+    return uniprotId ? (React.createElement(React.Fragment, null,
         React.createElement(Typography, null,
-            "Found Uniprot ID: ",
-            foundStructureId),
-        loading ? (React.createElement(LoadingEllipses, { title: "Looking up structure in AlphaFoldDB" })) : success ? (React.createElement(Typography, null, "Found structure in AlphaFoldDB")) : (React.createElement(Typography, null,
-            "No structure found for this UniProtID in AlphaFoldDB",
+            "Found Uniprot ID:",
             ' ',
-            React.createElement(Link, { target: "_blank", href: `https://alphafold.ebi.ac.uk/search/text/${foundStructureId}` }, "(search for results)")))));
+            React.createElement("a", { href: url2, target: "_blank", rel: "noreferrer" }, uniprotId)),
+        React.createElement(Typography, null,
+            "AlphaFoldDB link:",
+            ' ',
+            React.createElement("a", { href: url, target: "_blank", rel: "noreferrer" }, url)),
+        structureSequence ? (React.createElement("div", { style: { margin: 20 } },
+            React.createElement(Button, { variant: "contained", color: "primary", onClick: () => {
+                    setShowAllProteinSequences(!showAllProteinSequences);
+                } }, showAllProteinSequences
+                ? 'Hide all isoform protein sequences'
+                : 'Show all isoform protein sequences'),
+            showAllProteinSequences ? (React.createElement(MSATable, { structureSequence: structureSequence, structureName: uniprotId, isoformSequences: isoformSequences })) : null)) : (React.createElement(NotFound, { uniprotId: uniprotId })))) : (React.createElement(Typography, null,
+        "Searching ",
+        getDisplayName(selectedTranscript),
+        " for UniProt ID"));
 }
 //# sourceMappingURL=AlphaFoldDBSearchStatus.js.map

package/dist/LaunchProteinView/components/AlphaFoldDBSearchStatus.js.map

@@ -1 +1 @@
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package/dist/LaunchProteinView/components/HelpButton.js

@@ -7,9 +7,13 @@ const HelpDialog = lazy(() => import('./HelpDialog'));
 export default function HelpButton() {
     const [show, setShow] = useState(false);
     return (React.createElement(React.Fragment, null,
-        React.createElement(IconButton, { onClick: () => setShow(true) },
+        React.createElement(IconButton, { onClick: () => {
+                setShow(true);
+            } },
             React.createElement(Help, null)),
         show ? (React.createElement(Suspense, { fallback: null },
-            React.createElement(HelpDialog, { handleClose: () => setShow(false) }))) : null));
+            React.createElement(HelpDialog, { handleClose: () => {
+                    setShow(false);
+                } }))) : null));
 }
 //# sourceMappingURL=HelpButton.js.map

package/dist/LaunchProteinView/components/HelpButton.js.map

@@ -1 +1 @@
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+{"version":3,"file":"HelpButton.js","sourceRoot":"","sources":["../../../src/LaunchProteinView/components/HelpButton.tsx"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,EAAE,QAAQ,EAAE,IAAI,EAAE,QAAQ,EAAE,MAAM,OAAO,CAAA;AACvD,OAAO,EAAE,UAAU,EAAE,MAAM,eAAe,CAAA;AAC1C,QAAQ;AACR,OAAO,IAAI,MAAM,0BAA0B,CAAA;AAE3C,SAAS;AACT,MAAM,UAAU,GAAG,IAAI,CAAC,GAAG,EAAE,CAAC,MAAM,CAAC,cAAc,CAAC,CAAC,CAAA;AAErD,MAAM,CAAC,OAAO,UAAU,UAAU;IAChC,MAAM,CAAC,IAAI,EAAE,OAAO,CAAC,GAAG,QAAQ,CAAC,KAAK,CAAC,CAAA;IACvC,OAAO,CACL;QACE,oBAAC,UAAU,IACT,OAAO,EAAE,GAAG,EAAE;gBACZ,OAAO,CAAC,IAAI,CAAC,CAAA;YACf,CAAC;YAED,oBAAC,IAAI,OAAG,CACG;QACZ,IAAI,CAAC,CAAC,CAAC,CACN,oBAAC,QAAQ,IAAC,QAAQ,EAAE,IAAI;YACtB,oBAAC,UAAU,IACT,WAAW,EAAE,GAAG,EAAE;oBAChB,OAAO,CAAC,KAAK,CAAC,CAAA;gBAChB,CAAC,GACD,CACO,CACZ,CAAC,CAAC,CAAC,IAAI,CACP,CACJ,CAAA;AACH,CAAC"}

package/dist/LaunchProteinView/components/HelpDialog.js

@@ -5,12 +5,21 @@ function Typography2({ children }) {
     return React.createElement(Typography, { style: { margin: 4 } }, children);
 }
 export default function HelpDialog({ handleClose, }) {
-    return (React.createElement(Dialog, { open: true, maxWidth: "lg", onClose: handleClose, title: "Protein alignment" },
+    return (React.createElement(Dialog, { open: true, maxWidth: "lg", onClose: handleClose, title: "Help" },
         React.createElement(DialogContent, null,
-            React.createElement(Typography2, null, "This process searches mygene.info for the transcript ID, in order to retrieve the UniProt ID associated with a given transcript ID. Then, it uses that UniProt ID to lookup the structure in AlphaFoldDB because every UniProt ID has been processed by AlphaFold."),
-            React.createElement(Typography2, null, "If you run into challenges with this workflow e.g. your transcripts are not being found in mygene.info and you are interested in using this plugin, contact colin.diesh@gmail.com")),
+            React.createElement(Typography2, null,
+                "The procedure for the protein lookup is as follows:",
+                React.createElement("ul", null,
+                    React.createElement("li", null, "(Automatic lookup) Searches mygene.info for the transcript ID, in order to retrieve the UniProt ID associated with a given transcript ID and then, the UniProt ID is used to lookup the structure in AlphaFoldDB"),
+                    React.createElement("li", null, "(Manual) Allows you to choose your own structure file from your local machine (e.g. a PDB file predicted by e.g. ColabFold) or supply a specific URL"),
+                    React.createElement("li", null, "The residues from the structure are downloaded, and then you can choose the transcript isoform from the selected gene that best represents the structure. Asterisks are displayed if there is an exact sequence match"),
+                    React.createElement("li", null, "The residues from the structure are finally aligned to the to the selected transcript's protein sequence representation, and this creates a mapping from the reference genome coordinates to positions in the 3-D structure"),
+                    React.createElement("li", null, "Finally the molstar panel is opened, and this contains many specialized features features, plus additional mouseover and selection features supplied by the plugin to connect mouse click actions and mouse hover with coordinates on the linear genome view"))),
+            React.createElement(Typography2, null, "If you run into challenges with this workflow e.g. your transcripts are not being found in mygene.info then you can use the Manual import form, or contact colin.diesh@gmail.com for troubleshooting")),
         React.createElement(Divider, null),
         React.createElement(DialogActions, null,
-            React.createElement(Button, { onClick: () => handleClose(), color: "primary" }, "Close"))));
+            React.createElement(Button, { onClick: () => {
+                    handleClose();
+                }, color: "primary" }, "Close"))));
 }
 //# sourceMappingURL=HelpDialog.js.map

package/dist/LaunchProteinView/components/HelpDialog.js.map

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package/dist/LaunchProteinView/components/LaunchProteinViewDialog.js

@@ -2,22 +2,22 @@ import React, { useState } from 'react';
 import { Dialog } from '@jbrowse/core/ui';
 import { Tab, Tabs } from '@mui/material';
 // locals
-import PreLoadedStructureMapping from './PreLoadedStructureMapping';
 import AlphaFoldDBSearch from './AlphaFoldDBSearch';
 import UserProvidedStructure from './UserProvidedStructure';
 import TabPanel from './TabPanel';
 export default function LaunchProteinViewDialog({ handleClose, feature, model, }) {
     const [choice, setChoice] = useState(0);
-    return (React.createElement(Dialog, { maxWidth: "xl", title: "Launch protein view", onClose: () => handleClose(), open: true },
-        React.createElement(Tabs, { value: choice, onChange: (_, val) => setChoice(val) },
-            React.createElement(Tab, { value: 0, label: "AlphaFoldDB search" }),
-            React.createElement(Tab, { value: 1, label: "Manual" }),
-            React.createElement(Tab, { value: 2, label: "Pre-configured" })),
+    return (React.createElement(Dialog, { maxWidth: "xl", title: "Launch protein view", onClose: () => {
+            handleClose();
+        }, open: true },
+        React.createElement(Tabs, { value: choice, onChange: (_, val) => {
+                setChoice(val);
+            } },
+            React.createElement(Tab, { value: 0, label: "Automatic lookup" }),
+            React.createElement(Tab, { value: 1, label: "Manual" })),
         React.createElement(TabPanel, { value: choice, index: 0 },
             React.createElement(AlphaFoldDBSearch, { model: model, feature: feature, handleClose: handleClose })),
         React.createElement(TabPanel, { value: choice, index: 1 },
-            React.createElement(UserProvidedStructure, { model: model, feature: feature, handleClose: handleClose })),
-        React.createElement(TabPanel, { value: choice, index: 2 },
-            React.createElement(PreLoadedStructureMapping, { feature: feature, model: model, handleClose: handleClose }))));
+            React.createElement(UserProvidedStructure, { model: model, feature: feature, handleClose: handleClose }))));
 }
 //# sourceMappingURL=LaunchProteinViewDialog.js.map

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package/dist/LaunchProteinView/components/MSATable.d.ts

@@ -0,0 +1,10 @@
+import React from 'react';
+import { Feature } from '@jbrowse/core/util';
+export default function MSATable({ structureName, structureSequence, isoformSequences, }: {
+    structureName: string;
+    structureSequence: string;
+    isoformSequences: Record<string, {
+        feature: Feature;
+        seq: string;
+    }>;
+}): React.JSX.Element;

package/dist/LaunchProteinView/components/MSATable.js

@@ -0,0 +1,55 @@
+import React, { useState } from 'react';
+import { Checkbox, FormControlLabel, TextField } from '@mui/material';
+import { max } from '@jbrowse/core/util';
+import { makeStyles } from 'tss-react/mui';
+// locals
+import { getTranscriptDisplayName } from './util';
+const useStyles = makeStyles()({
+    textAreaFont: {
+        fontFamily: 'Courier New',
+        whiteSpace: 'pre',
+    },
+    margin: {
+        marginLeft: 20,
+    },
+});
+export default function MSATable({ structureName, structureSequence, isoformSequences, }) {
+    const { classes } = useStyles();
+    const [showInFastaFormat, setShowInFastaFormat] = useState(false);
+    const removedStars = Object.fromEntries(Object.entries(isoformSequences).map(([key, val]) => [
+        key,
+        { ...val, seq: val.seq.replaceAll('*', '') },
+    ]));
+    const exactMatchIsoformAndStructureSeq = Object.entries(removedStars).find(([_, val]) => structureSequence === val.seq);
+    const sname = `${structureName || ''} (structure residues)`;
+    const maxKeyLen = max([
+        sname.length,
+        ...Object.entries(removedStars).map(([_, val]) => getTranscriptDisplayName(val.feature).length),
+    ]);
+    const l1 = [
+        `${sname.padEnd(maxKeyLen)}${exactMatchIsoformAndStructureSeq ? '*' : ' '} ${structureSequence}`,
+        exactMatchIsoformAndStructureSeq
+            ? `${getTranscriptDisplayName(exactMatchIsoformAndStructureSeq[1].feature).padEnd(maxKeyLen)}* ${exactMatchIsoformAndStructureSeq[1].seq}`
+            : undefined,
+        ...Object.entries(removedStars)
+            .map(([_, val]) => `${getTranscriptDisplayName(val.feature).padEnd(maxKeyLen)}  ${val.seq}`)
+            .filter(([k]) => k !== exactMatchIsoformAndStructureSeq?.[0]),
+    ]
+        .filter(f => !!f)
+        .join('\n');
+    const l2 = [
+        `>${sname}\n${structureSequence}`,
+        ...Object.values(removedStars).map(({ feature, seq }) => `>${getTranscriptDisplayName(feature)}\n${seq}`),
+    ].join('\n');
+    return (React.createElement(React.Fragment, null,
+        React.createElement(FormControlLabel, { className: classes.margin, control: React.createElement(Checkbox, { onChange: event => {
+                    setShowInFastaFormat(event.target.checked);
+                }, checked: showInFastaFormat }), label: "Show in FASTA format?" }),
+        React.createElement(TextField, { variant: "outlined", multiline: true, minRows: 5, maxRows: 10, fullWidth: true, value: showInFastaFormat ? l2 : l1, InputProps: {
+                readOnly: true,
+                classes: {
+                    input: classes.textAreaFont,
+                },
+            } })));
+}
+//# sourceMappingURL=MSATable.js.map

package/dist/LaunchProteinView/components/MSATable.js.map

@@ -0,0 +1 @@
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package/dist/LaunchProteinView/components/TranscriptSelector.d.ts

@@ -1,9 +1,13 @@
 import React from 'react';
 import { Feature } from '@jbrowse/core/util';
-export default function TranscriptSelector({ val, setVal, options, feature, seqs, }: {
-    options: Feature[];
+export default function TranscriptSelector({ val, setVal, isoforms, isoformSequences, structureSequence, feature, }: {
+    isoforms: Feature[];
     feature: Feature;
     val: string;
     setVal: (str: string) => void;
-    seqs: Record<string, string>;
+    structureSequence: string;
+    isoformSequences: Record<string, {
+        feature: Feature;
+        seq: string;
+    }>;
 }): React.JSX.Element;