jbrowse-plugin-msaview 3.7.0 → 3.7.1

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Files changed (22) hide show
  1. package/README.md +44 -30
  2. package/dist/LaunchMsaViewExtensionPoint/index.js +25 -2
  3. package/dist/LaunchMsaViewExtensionPoint/index.test.js +45 -0
  4. package/dist/MsaViewPanel/model.d.ts +10 -11
  5. package/dist/MsaViewPanel/model.js +0 -17
  6. package/dist/jbrowse-plugin-msaview.umd.production.min.js +35 -33
  7. package/dist/jbrowse-plugin-msaview.umd.production.min.js.map +4 -4
  8. package/dist/utils/unirefHomologs.js +1 -1
  9. package/dist/version.d.ts +1 -1
  10. package/dist/version.js +1 -1
  11. package/package.json +5 -4
  12. package/src/LaunchMsaViewExtensionPoint/index.test.ts +48 -0
  13. package/src/LaunchMsaViewExtensionPoint/index.ts +44 -8
  14. package/src/MsaViewPanel/model.ts +0 -22
  15. package/src/utils/unirefHomologs.ts +1 -1
  16. package/src/version.ts +1 -1
  17. package/dist/MsaViewPanel/applyRegion.d.ts +0 -23
  18. package/dist/MsaViewPanel/applyRegion.js +0 -19
  19. package/dist/MsaViewPanel/applyRegion.test.d.ts +0 -1
  20. package/dist/MsaViewPanel/applyRegion.test.js +0 -45
  21. package/src/MsaViewPanel/applyRegion.test.ts +0 -55
  22. package/src/MsaViewPanel/applyRegion.ts +0 -33
package/dist/jbrowse-plugin-msaview.umd.production.min.js CHANGED
@@ -1,4 +1,4 @@
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Ue({htmlFontSize:l,pxToRem:d,fontFamily:r,fontSize:n,fontWeightLight:o,fontWeightRegular:i,fontWeightMedium:s,fontWeightBold:a,...h},f,{clone:!1})}var A1,g1,h1=A(()=>{sn();A1={textTransform:"uppercase"},g1='"Roboto", "Helvetica", "Arial", sans-serif'});function De(...e){return[`${e[0]}px ${e[1]}px ${e[2]}px ${e[3]}px rgba(0,0,0,${.2})`,`${e[4]}px ${e[5]}px ${e[6]}px ${e[7]}px rgba(0,0,0,${.14})`,`${e[8]}px ${e[9]}px ${e[10]}px ${e[11]}px rgba(0,0,0,${.12})`].join(",")}var JV,y1,b1=A(()=>{JV=["none",De(0,2,1,-1,0,1,1,0,0,1,3,0),De(0,3,1,-2,0,2,2,0,0,1,5,0),De(0,3,3,-2,0,3,4,0,0,1,8,0),De(0,2,4,-1,0,4,5,0,0,1,10,0),De(0,3,5,-1,0,5,8,0,0,1,14,0),De(0,3,5,-1,0,6,10,0,0,1,18,0),De(0,4,5,-2,0,7,10,1,0,2,16,1),De(0,5,5,-3,0,8,10,1,0,3,14,2),De(0,5,6,-3,0,9,12,1,0,3,16,2),De(0,6,6,-3,0,10,14,1,0,4,18,3),De(0,6,7,-4,0,11,15,1,0,4,20,3),De(0,7,8,-4,0,12,17,2,0,5,22,4),De(0,7,8,-4,0,13,19,2,0,5,24,4),De(0,7,9,-4,0,14,21,2,0,5,26,4),De(0,8,9,-5,0,15,22,2,0,6,28,5),De(0,8,10,-5,0,16,24,2,0,6,30,5),De(0,8,11,-5,0,17,26,2,0,6,32,5),De(0,9,11,-5,0,18,28,2,0,7,34,6),De(0,9,12,-6,0,19,29,2,0,7,36,6),De(0,10,13,-6,0,20,31,3,0,8,38,7),De(0,10,13,-6,0,21,33,3,0,8,40,7),De(0,10,14,-6,0,22,35,3,0,8,42,7),De(0,11,14,-7,0,23,36,3,0,9,44,8),De(0,11,15,-7,0,24,38,3,0,9,46,8)],y1=JV});function C1(e){return`${Math.round(e)}ms`}function tj(e){if(!e)return 0;let t=e/36;return Math.min(Math.round((4+15*t**.25+t/5)*10),3e3)}function m0(e){let t={...e};delete t.reducedMotion;let r={...ZV,...t.easing},n={...ej,...t.duration},o=(s=KV,a=XV)=>{let{duration:l=n.standard,easing:c=r.easeInOut,delay:u=0,...f}=a;return(Array.isArray(s)?s:[s]).map(m=>`${m} ${typeof l=="string"?l:C1(l)} ${c} ${typeof u=="string"?u:C1(u)}`).join(",")},i=t.create??o;return{getAutoHeightDuration:tj,create:i,...t,easing:r,duration:n}}var KV,XV,ZV,ej,x1=A(()=>{KV=["all"],XV={},ZV={easeInOut:"cubic-bezier(0.4, 0, 0.2, 1)",easeOut:"cubic-bezier(0.0, 0, 0.2, 1)",easeIn:"cubic-bezier(0.4, 0, 1, 1)",sharp:"cubic-bezier(0.4, 0, 0.6, 1)"},ej={shortest:150,shorter:200,short:250,standard:300,complex:375,enteringScreen:225,leavingScreen:195}});function p0(e=rj){return{reducedMotion:"never",...e}}var rj,E1=A(()=>{rj={}});var nj,w1,S1=A(()=>{nj={mobileStepper:1e3,fab:1050,speedDial:1050,appBar:1100,drawer:1200,modal:1300,snackbar:1400,tooltip:1500},w1=nj});function oj(e){return Or(e)||typeof e>"u"||typeof e=="string"||typeof e=="boolean"||typeof e=="number"||Array.isArray(e)}function Ld(e={}){let t={...e};function r(n){let o=Object.entries(n);for(let i=0;i<o.length;i++){let[s,a]=o[i];!oj(a)||s.startsWith("unstable_")||s.startsWith("internal_")?delete n[s]:Or(a)&&(n[s]={...a},r(n[s]))}}return r(t),`import { unstable_createBreakpoints as createBreakpoints, createTransitions } from '@mui/material/styles';
2
2
 
3
3
  const theme = ${JSON.stringify(t,null,2)};
4
4
 
@@ -6,8 +6,9 @@ theme.breakpoints = createBreakpoints(theme.breakpoints || {});
6
6
  theme.motion = { reducedMotion: 'never', ...theme.motion };
7
7
  theme.transitions = createTransitions(theme.transitions || {});
8
8
 
9
- export default theme;`}var m0=A(()=>{sn()});function w1(e){return typeof e=="number"?`${(e*100).toFixed(0)}%`:`calc((${e}) * 100%)`}function XV(e){Object.assign(e,{alpha(t,r){let n=this||e;return n.colorSpace?`oklch(from ${t} l c h / ${typeof r=="string"?`calc(${r})`:r})`:n.vars?`rgba(${t.replace(/var\(--([^,\s)]+)(?:,[^)]+)?\)+/g,"var(--$1Channel)")} / ${typeof r=="string"?`calc(${r})`:r})`:Xh(t,KV(r))},lighten(t,r){let n=this||e;return n.colorSpace?`color-mix(in ${n.colorSpace}, ${t}, #fff ${w1(r)})`:ma(t,r)},darken(t,r){let n=this||e;return n.colorSpace?`color-mix(in ${n.colorSpace}, ${t}, #000 ${w1(r)})`:da(t,r)}})}function ZV(e={},...t){let{breakpoints:r,mixins:n={},spacing:o,palette:i={},motion:s={},transitions:a={},typography:l={},shape:c,colorSpace:u,...f}=e;if(e.vars&&e.generateThemeVars===void 0)throw new Error(Gt(22));let m=Ri({...i,colorSpace:u}),d=Ii(e),p=$e(d,{mixins:l0(d.breakpoints,n),palette:m,shadows:g1.slice(),typography:u0(m,l),motion:d0(s),transitions:f0(a),zIndex:{...x1}});return p=$e(p,f),p=t.reduce((h,y)=>$e(h,y),p),delete p.transitions.reducedMotion,p.focusVisible!=null&&p.focusVisible!==!1&&(p.focusVisible=Aa(p.focusVisible,p.palette.primary.main)),p.unstable_sxConfig={...Un,...f?.unstable_sxConfig},p.unstable_sx=function(y){return pr({sx:y,theme:this})},p.toRuntimeSource=Fd,XV(p),p}var KV,Sl,p0=A(()=>{Hs();sn();nl();Sd();Cl();d1();wl();A1();h1();b1();C1();E1();m0();Nd();KV=e=>{if(!Number.isNaN(+e))return+e;let t=e.match(/\d*\.?\d+/g);if(!t)return 0;let r=0;for(let n=0;n<t.length;n+=1)r+=+t[n];return r};Sl=ZV});function A0(e){let t;return e<1?t=5.11916*e**2:t=4.5*Math.log(e+1)+2,Math.round(t*10)/1e3}var S1=A(()=>{});function g0(e){return{inputPlaceholder:e==="dark"?.5:.42,inputUnderline:e==="dark"?.7:.42,switchTrackDisabled:e==="dark"?.2:.12,switchTrack:e==="dark"?.3:.38}}function h0(e){return e==="dark"?e7:[]}function y0(e){let{palette:t={mode:"light"},opacity:r,overlays:n,colorSpace:o,...i}=e,s=Ri({...t,colorSpace:o});return{palette:s,opacity:{...g0(s.mode),...r},overlays:n||h0(s.mode),...i}}var e7,I1=A(()=>{wl();S1();e7=[...Array(25)].map((e,t)=>{if(t===0)return"none";let r=A0(t);return`linear-gradient(rgba(255 255 255 / ${r}), rgba(255 255 255 / ${r}))`})});function b0(e){return e[0]==="motion"||e[0]==="focusVisible"||!!e[0].match(/(cssVarPrefix|colorSchemeSelector|modularCssLayers|rootSelector|typography|mixins|breakpoints|direction|transitions)/)||!!e[0].match(/sxConfig$/)||e[0]==="palette"&&!!e[1]?.match(/(mode|contrastThreshold|tonalOffset)/)}var v1=A(()=>{});var t7,B1,T1=A(()=>{t7=e=>[...[...Array(25)].map((t,r)=>`--${e?`${e}-`:""}overlays-${r}`),`--${e?`${e}-`:""}palette-AppBar-darkBg`,`--${e?`${e}-`:""}palette-AppBar-darkColor`],B1=t7});var M1,R1=A(()=>{T1();M1=e=>(t,r)=>{let n=e.rootSelector||":root",o=e.colorSchemeSelector,i=o;if(o==="class"&&(i=".%s"),o==="data"&&(i="[data-%s]"),o?.startsWith("data-")&&!o.includes("%s")&&(i=`[${o}="%s"]`),e.defaultColorScheme===t){if(t==="dark"){let s={};return B1(e.cssVarPrefix).forEach(a=>{s[a]=r[a],delete r[a]}),i==="media"?{[n]:r,"@media (prefers-color-scheme: dark)":{[n]:s}}:i?{[i.replace("%s",t)]:s,[`${n}, ${i.replace("%s",t)}`]:r}:{[n]:{...r,...s}}}if(i&&i!=="media")return`${n}, ${i.replace("%s",String(t))}`}else if(t){if(i==="media")return{[`@media (prefers-color-scheme: ${String(t)})`]:{[n]:r}};if(i)return i.replace("%s",String(t))}return n}});function r7(e,t){t.forEach(r=>{e[r]||(e[r]={})})}function D(e,t,r){!e[t]&&r&&(e[t]=r)}function Il(e){return typeof e!="string"||!e.startsWith("hsl")?e:Kh(e)}function jn(e,t){`${t}Channel`in e||(e[`${t}Channel`]=fa(Il(e[t]),`MUI: Can't create \`palette.${t}Channel\` because \`palette.${t}\` is not one of these formats: #nnn, #nnnnnn, rgb(), rgba(), hsl(), hsla(), color().
10
- To suppress this warning, you need to explicitly provide the \`palette.${t}Channel\` as a string (in rgb format, for example "12 12 12") or undefined if you want to remove the channel token.`))}function n7(e){return typeof e=="number"?`${e}px`:typeof e=="string"||typeof e=="function"||Array.isArray(e)?e:"8px"}function C0(e,t,r,n,o){if(!r)return;r=r===!0?{}:r;let i=o==="dark"?"dark":"light";if(!n){t[o]=y0({...r,palette:{mode:i,...r?.palette},colorSpace:e});return}let{palette:s,...a}=Sl({...n,palette:{mode:i,...r?.palette},colorSpace:e});return t[o]={...r,palette:s,opacity:{...g0(i),...r?.opacity},overlays:r?.overlays||h0(i)},a}function x0(e={},...t){let{colorSchemes:r={light:!0},defaultColorScheme:n,disableCssColorScheme:o=!1,cssVarPrefix:i="mui",nativeColor:s=!1,shouldSkipGeneratingVar:a=b0,colorSchemeSelector:l=r.light&&r.dark?"media":void 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+ export default theme;`}var A0=A(()=>{sn()});function I1(e){return typeof e=="number"?`${(e*100).toFixed(0)}%`:`calc((${e}) * 100%)`}function sj(e){Object.assign(e,{alpha(t,r){let n=this||e;return n.colorSpace?`oklch(from ${t} l c h / ${typeof r=="string"?`calc(${r})`:r})`:n.vars?`rgba(${t.replace(/var\(--([^,\s)]+)(?:,[^)]+)?\)+/g,"var(--$1Channel)")} / ${typeof r=="string"?`calc(${r})`:r})`:e0(t,ij(r))},lighten(t,r){let n=this||e;return n.colorSpace?`color-mix(in ${n.colorSpace}, ${t}, #fff ${I1(r)})`:ma(t,r)},darken(t,r){let n=this||e;return n.colorSpace?`color-mix(in ${n.colorSpace}, ${t}, #000 ${I1(r)})`:da(t,r)}})}function aj(e={},...t){let{breakpoints:r,mixins:n={},spacing:o,palette:i={},motion:s={},transitions:a={},typography:l={},shape:c,colorSpace:u,...f}=e;if(e.vars&&e.generateThemeVars===void 0)throw new Error(Gt(22));let m=Ri({...i,colorSpace:u}),d=Ii(e),p=Ue(d,{mixins:f0(d.breakpoints,n),palette:m,shadows:y1.slice(),typography:d0(m,l),motion:p0(s),transitions:m0(a),zIndex:{...w1}});return p=Ue(p,f),p=t.reduce((h,y)=>Ue(h,y),p),delete p.transitions.reducedMotion,p.focusVisible!=null&&p.focusVisible!==!1&&(p.focusVisible=Aa(p.focusVisible,p.palette.primary.main)),p.unstable_sxConfig={...Un,...f?.unstable_sxConfig},p.unstable_sx=function(y){return pr({sx:y,theme:this})},p.toRuntimeSource=Ld,sj(p),p}var ij,Sl,g0=A(()=>{Hs();sn();nl();wd();Cl();p1();wl();h1();b1();x1();E1();S1();A0();Dd();ij=e=>{if(!Number.isNaN(+e))return+e;let t=e.match(/\d*\.?\d+/g);if(!t)return 0;let r=0;for(let n=0;n<t.length;n+=1)r+=+t[n];return r};Sl=aj});function h0(e){let t;return e<1?t=5.11916*e**2:t=4.5*Math.log(e+1)+2,Math.round(t*10)/1e3}var v1=A(()=>{});function y0(e){return{inputPlaceholder:e==="dark"?.5:.42,inputUnderline:e==="dark"?.7:.42,switchTrackDisabled:e==="dark"?.2:.12,switchTrack:e==="dark"?.3:.38}}function b0(e){return e==="dark"?cj:[]}function C0(e){let{palette:t={mode:"light"},opacity:r,overlays:n,colorSpace:o,...i}=e,s=Ri({...t,colorSpace:o});return{palette:s,opacity:{...y0(s.mode),...r},overlays:n||b0(s.mode),...i}}var cj,B1=A(()=>{wl();v1();cj=[...Array(25)].map((e,t)=>{if(t===0)return"none";let r=h0(t);return`linear-gradient(rgba(255 255 255 / ${r}), rgba(255 255 255 / ${r}))`})});function x0(e){return e[0]==="motion"||e[0]==="focusVisible"||!!e[0].match(/(cssVarPrefix|colorSchemeSelector|modularCssLayers|rootSelector|typography|mixins|breakpoints|direction|transitions)/)||!!e[0].match(/sxConfig$/)||e[0]==="palette"&&!!e[1]?.match(/(mode|contrastThreshold|tonalOffset)/)}var T1=A(()=>{});var lj,M1,R1=A(()=>{lj=e=>[...[...Array(25)].map((t,r)=>`--${e?`${e}-`:""}overlays-${r}`),`--${e?`${e}-`:""}palette-AppBar-darkBg`,`--${e?`${e}-`:""}palette-AppBar-darkColor`],M1=lj});var k1,Q1=A(()=>{R1();k1=e=>(t,r)=>{let n=e.rootSelector||":root",o=e.colorSchemeSelector,i=o;if(o==="class"&&(i=".%s"),o==="data"&&(i="[data-%s]"),o?.startsWith("data-")&&!o.includes("%s")&&(i=`[${o}="%s"]`),e.defaultColorScheme===t){if(t==="dark"){let s={};return M1(e.cssVarPrefix).forEach(a=>{s[a]=r[a],delete r[a]}),i==="media"?{[n]:r,"@media (prefers-color-scheme: dark)":{[n]:s}}:i?{[i.replace("%s",t)]:s,[`${n}, ${i.replace("%s",t)}`]:r}:{[n]:{...r,...s}}}if(i&&i!=="media")return`${n}, ${i.replace("%s",String(t))}`}else if(t){if(i==="media")return{[`@media (prefers-color-scheme: ${String(t)})`]:{[n]:r}};if(i)return i.replace("%s",String(t))}return n}});function uj(e,t){t.forEach(r=>{e[r]||(e[r]={})})}function D(e,t,r){!e[t]&&r&&(e[t]=r)}function Il(e){return typeof e!="string"||!e.startsWith("hsl")?e:Zh(e)}function jn(e,t){`${t}Channel`in e||(e[`${t}Channel`]=fa(Il(e[t]),`MUI: Can't create \`palette.${t}Channel\` because \`palette.${t}\` is not one of these formats: #nnn, #nnnnnn, rgb(), rgba(), hsl(), hsla(), color().
10
+ To suppress this warning, you need to explicitly provide the \`palette.${t}Channel\` as a string (in rgb format, for example "12 12 12") or undefined if you want to remove the channel token.`))}function fj(e){return typeof e=="number"?`${e}px`:typeof e=="string"||typeof e=="function"||Array.isArray(e)?e:"8px"}function E0(e,t,r,n,o){if(!r)return;r=r===!0?{}:r;let i=o==="dark"?"dark":"light";if(!n){t[o]=C0({...r,palette:{mode:i,...r?.palette},colorSpace:e});return}let{palette:s,...a}=Sl({...n,palette:{mode:i,...r?.palette},colorSpace:e});return t[o]={...r,palette:s,opacity:{...y0(i),...r?.opacity},overlays:r?.overlays||b0(i)},a}function w0(e={},...t){let{colorSchemes:r={light:!0},defaultColorScheme:n,disableCssColorScheme:o=!1,cssVarPrefix:i="mui",nativeColor:s=!1,shouldSkipGeneratingVar:a=x0,colorSchemeSelector:l=r.light&&r.dark?"media":void 0,rootSelector:c=":root",...u}=e,f=Object.keys(r)[0],m=n||(r.light&&f!=="light"?"light":f),d=dj(i),{[m]:p,light:h,dark:y,...b}=r,C={...b},I=p;if((m==="dark"&&!("dark"in r)||m==="light"&&!("light"in r))&&(I=!0),!I)throw new Error(Gt(21,m));let x;s&&(x="oklch");let S=E0(x,C,I,u,m);h&&!C.light&&E0(x,C,h,void 0,"light"),y&&!C.dark&&E0(x,C,y,void 0,"dark");let v={defaultColorScheme:m,...S,cssVarPrefix:i,colorSchemeSelector:l,rootSelector:c,getCssVar:d,colorSchemes:C,font:{...Nd(S.typography),...S.font},spacing:fj(u.spacing)};Object.keys(v.colorSchemes).forEach(G=>{let E=v.colorSchemes[G].palette,R=U=>{let J=U.split("-"),X=J[1],ie=J[2];return d(U,E[X][ie])};E.mode==="light"&&(D(E.common,"background","#fff"),D(E.common,"onBackground","#000")),E.mode==="dark"&&(D(E.common,"background","#000"),D(E.common,"onBackground","#fff"));function L(U,J,X){if(x){let ie;return U===Mo&&(ie=`transparent ${((1-X)*100).toFixed(0)}%`),U===de&&(ie=`#000 ${(X*100).toFixed(0)}%`),U===me&&(ie=`#fff 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U(J,X)}if(uj(E,["Alert","AppBar","Avatar","Button","Chip","FilledInput","LinearProgress","Skeleton","Slider","SnackbarContent","SpeedDialAction","StepConnector","StepContent","Switch","TableCell","Tooltip"]),E.mode==="light"){D(E.Alert,"errorColor",L(de,s?d("palette-error-light"):E.error.light,.6)),D(E.Alert,"infoColor",L(de,s?d("palette-info-light"):E.info.light,.6)),D(E.Alert,"successColor",L(de,s?d("palette-success-light"):E.success.light,.6)),D(E.Alert,"warningColor",L(de,s?d("palette-warning-light"):E.warning.light,.6)),D(E.Alert,"errorFilledBg",R("palette-error-main")),D(E.Alert,"infoFilledBg",R("palette-info-main")),D(E.Alert,"successFilledBg",R("palette-success-main")),D(E.Alert,"warningFilledBg",R("palette-warning-main")),D(E.Alert,"errorFilledColor",mn(()=>E.getContrastText(E.error.main))),D(E.Alert,"infoFilledColor",mn(()=>E.getContrastText(E.info.main))),D(E.Alert,"successFilledColor",mn(()=>E.getContrastText(E.success.main))),D(E.Alert,"warningFilledColor",mn(()=>E.getContrastText(E.warning.main))),D(E.Alert,"errorStandardBg",L(me,s?d("palette-error-light"):E.error.light,.9)),D(E.Alert,"infoStandardBg",L(me,s?d("palette-info-light"):E.info.light,.9)),D(E.Alert,"successStandardBg",L(me,s?d("palette-success-light"):E.success.light,.9)),D(E.Alert,"warningStandardBg",L(me,s?d("palette-warning-light"):E.warning.light,.9)),D(E.Alert,"errorIconColor",R("palette-error-main")),D(E.Alert,"infoIconColor",R("palette-info-main")),D(E.Alert,"successIconColor",R("palette-success-main")),D(E.Alert,"warningIconColor",R("palette-warning-main")),D(E.AppBar,"defaultBg",R("palette-grey-100")),D(E.Avatar,"defaultBg",R("palette-grey-400")),D(E.Button,"inheritContainedBg",R("palette-grey-300")),D(E.Button,"inheritContainedHoverBg",R("palette-grey-A100")),D(E.Chip,"defaultBorder",R("palette-grey-400")),D(E.Chip,"defaultAvatarColor",R("palette-grey-700")),D(E.Chip,"defaultIconColor",R("palette-grey-700")),D(E.FilledInput,"bg","rgba(0, 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0.11)`),D(E.Slider,"primaryTrack",L(me,s?d("palette-primary-main"):E.primary.main,.62)),D(E.Slider,"secondaryTrack",L(me,s?d("palette-secondary-main"):E.secondary.main,.62)),D(E.Slider,"errorTrack",L(me,s?d("palette-error-main"):E.error.main,.62)),D(E.Slider,"infoTrack",L(me,s?d("palette-info-main"):E.info.main,.62)),D(E.Slider,"successTrack",L(me,s?d("palette-success-main"):E.success.main,.62)),D(E.Slider,"warningTrack",L(me,s?d("palette-warning-main"):E.warning.main,.62));let U=x?L(de,s?d("palette-background-default"):E.background.default,.6825):bl(E.background.default,.8);D(E.SnackbarContent,"bg",U),D(E.SnackbarContent,"color",mn(()=>x?kd.text.primary:E.getContrastText(U))),D(E.SpeedDialAction,"fabHoverBg",bl(E.background.paper,.15)),D(E.StepConnector,"border",R("palette-grey-400")),D(E.StepContent,"border",R("palette-grey-400")),D(E.Switch,"defaultColor",R("palette-common-white")),D(E.Switch,"defaultDisabledColor",R("palette-grey-100")),D(E.Switch,"primaryDisabledColor",L(me,s?d("palette-primary-main"):E.primary.main,.62)),D(E.Switch,"secondaryDisabledColor",L(me,s?d("palette-secondary-main"):E.secondary.main,.62)),D(E.Switch,"errorDisabledColor",L(me,s?d("palette-error-main"):E.error.main,.62)),D(E.Switch,"infoDisabledColor",L(me,s?d("palette-info-main"):E.info.main,.62)),D(E.Switch,"successDisabledColor",L(me,s?d("palette-success-main"):E.success.main,.62)),D(E.Switch,"warningDisabledColor",L(me,s?d("palette-warning-main"):E.warning.main,.62)),D(E.TableCell,"border",L(me,Mo(s?d("palette-divider"):E.divider,1),.88)),D(E.Tooltip,"bg",L(Mo,s?d("palette-grey-700"):E.grey[700],.92))}if(E.mode==="dark"){D(E.Alert,"errorColor",L(me,s?d("palette-error-light"):E.error.light,.6)),D(E.Alert,"infoColor",L(me,s?d("palette-info-light"):E.info.light,.6)),D(E.Alert,"successColor",L(me,s?d("palette-success-light"):E.success.light,.6)),D(E.Alert,"warningColor",L(me,s?d("palette-warning-light"):E.warning.light,.6)),D(E.Alert,"errorFilledBg",R("palette-error-dark")),D(E.Alert,"infoFilledBg",R("palette-info-dark")),D(E.Alert,"successFilledBg",R("palette-success-dark")),D(E.Alert,"warningFilledBg",R("palette-warning-dark")),D(E.Alert,"errorFilledColor",mn(()=>E.getContrastText(E.error.dark))),D(E.Alert,"infoFilledColor",mn(()=>E.getContrastText(E.info.dark))),D(E.Alert,"successFilledColor",mn(()=>E.getContrastText(E.success.dark))),D(E.Alert,"warningFilledColor",mn(()=>E.getContrastText(E.warning.dark))),D(E.Alert,"errorStandardBg",L(de,s?d("palette-error-light"):E.error.light,.9)),D(E.Alert,"infoStandardBg",L(de,s?d("palette-info-light"):E.info.light,.9)),D(E.Alert,"successStandardBg",L(de,s?d("palette-success-light"):E.success.light,.9)),D(E.Alert,"warningStandardBg",L(de,s?d("palette-warning-light"):E.warning.light,.9)),D(E.Alert,"errorIconColor",R("palette-error-main")),D(E.Alert,"infoIconColor",R("palette-info-main")),D(E.Alert,"successIconColor",R("palette-success-main")),D(E.Alert,"warningIconColor",R("palette-warning-main")),D(E.AppBar,"defaultBg",R("palette-grey-900")),D(E.AppBar,"darkBg",R("palette-background-paper")),D(E.AppBar,"darkColor",R("palette-text-primary")),D(E.Avatar,"defaultBg",R("palette-grey-600")),D(E.Button,"inheritContainedBg",R("palette-grey-800")),D(E.Button,"inheritContainedHoverBg",R("palette-grey-700")),D(E.Chip,"defaultBorder",R("palette-grey-700")),D(E.Chip,"defaultAvatarColor",R("palette-grey-300")),D(E.Chip,"defaultIconColor",R("palette-grey-300")),D(E.FilledInput,"bg","rgba(255, 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U=x?L(me,s?d("palette-background-default"):E.background.default,.985):bl(E.background.default,.98);D(E.SnackbarContent,"bg",U),D(E.SnackbarContent,"color",mn(()=>x?l0.text.primary:E.getContrastText(U))),D(E.SpeedDialAction,"fabHoverBg",bl(E.background.paper,.15)),D(E.StepConnector,"border",R("palette-grey-600")),D(E.StepContent,"border",R("palette-grey-600")),D(E.Switch,"defaultColor",R("palette-grey-300")),D(E.Switch,"defaultDisabledColor",R("palette-grey-600")),D(E.Switch,"primaryDisabledColor",L(de,s?d("palette-primary-main"):E.primary.main,.55)),D(E.Switch,"secondaryDisabledColor",L(de,s?d("palette-secondary-main"):E.secondary.main,.55)),D(E.Switch,"errorDisabledColor",L(de,s?d("palette-error-main"):E.error.main,.55)),D(E.Switch,"infoDisabledColor",L(de,s?d("palette-info-main"):E.info.main,.55)),D(E.Switch,"successDisabledColor",L(de,s?d("palette-success-main"):E.success.main,.55)),D(E.Switch,"warningDisabledColor",L(de,s?d("palette-warning-light"):E.warning.main,.55)),D(E.TableCell,"border",L(de,Mo(s?d("palette-divider"):E.divider,1),.68)),D(E.Tooltip,"bg",L(Mo,s?d("palette-grey-700"):E.grey[700],.92))}s||(jn(E.background,"default"),jn(E.background,"paper"),jn(E.common,"background"),jn(E.common,"onBackground"),jn(E,"divider")),Object.keys(E).forEach(U=>{let 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11
12
  ${e}\(
12
13
  ${t}*
13
14
  ${r}
@@ -16,41 +17,41 @@ To suppress this warning, you need to explicitly provide the \`palette.${t}Chann
16
17
  ${n}?
17
18
  ${n}?
18
19
  ${t}*
19
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qb.call(this._set,r)};no.prototype.indexOf=function(t){if(zi){var r=this._set.get(t);if(r>=0)return r}else{var n=Wb.toSetString(t);if(qb.call(this._set,n))return this._set[n]}throw new Error('"'+t+'" is not in the set.')};no.prototype.at=function(t){if(t>=0&&t<this._array.length)return this._array[t];throw new Error("No element indexed by "+t)};no.prototype.toArray=function(){return this._array.slice()};Kk.ArraySet=no});var eQ=ne(Zk=>{var Xk=Wa();function oY(e,t){var r=e.generatedLine,n=t.generatedLine,o=e.generatedColumn,i=t.generatedColumn;return n>r||n==r&&i>=o||Xk.compareByGeneratedPositionsInflated(e,t)<=0}function mp(){this._array=[],this._sorted=!0,this._last={generatedLine:-1,generatedColumn:0}}mp.prototype.unsortedForEach=function(t,r){this._array.forEach(t,r)};mp.prototype.add=function(t){oY(this._last,t)?(this._last=t,this._array.push(t)):(this._sorted=!1,this._array.push(t))};mp.prototype.toArray=function(){return this._sorted||(this._array.sort(Xk.compareByGeneratedPositionsInflated),this._sorted=!0),this._array};Zk.MappingList=mp});var Yb=ne(tQ=>{var hu=Vb(),Ke=Wa(),pp=zb().ArraySet,iY=eQ().MappingList;function Sr(e){e||(e={}),this._file=Ke.getArg(e,"file",null),this._sourceRoot=Ke.getArg(e,"sourceRoot",null),this._skipValidation=Ke.getArg(e,"skipValidation",!1),this._ignoreInvalidMapping=Ke.getArg(e,"ignoreInvalidMapping",!1),this._sources=new pp,this._names=new pp,this._mappings=new iY,this._sourcesContents=null}Sr.prototype._version=3;Sr.fromSourceMap=function(t,r){var n=t.sourceRoot,o=new Sr(Object.assign(r||{},{file:t.file,sourceRoot:n}));return t.eachMapping(function(i){var s={generated:{line:i.generatedLine,column:i.generatedColumn}};i.source!=null&&(s.source=i.source,n!=null&&(s.source=Ke.relative(n,s.source)),s.original={line:i.originalLine,column:i.originalColumn},i.name!=null&&(s.name=i.name)),o.addMapping(s)}),t.sources.forEach(function(i){var s=i;n!==null&&(s=Ke.relative(n,i)),o._sources.has(s)||o._sources.add(s);var a=t.sourceContentFor(i);a!=null&&o.setSourceContent(i,a)}),o};Sr.prototype.addMapping=function(t){var r=Ke.getArg(t,"generated"),n=Ke.getArg(t,"original",null),o=Ke.getArg(t,"source",null),i=Ke.getArg(t,"name",null);!this._skipValidation&&this._validateMapping(r,n,o,i)===!1||(o!=null&&(o=String(o),this._sources.has(o)||this._sources.add(o)),i!=null&&(i=String(i),this._names.has(i)||this._names.add(i)),this._mappings.add({generatedLine:r.line,generatedColumn:r.column,originalLine:n!=null&&n.line,originalColumn:n!=null&&n.column,source:o,name:i}))};Sr.prototype.setSourceContent=function(t,r){var n=t;this._sourceRoot!=null&&(n=Ke.relative(this._sourceRoot,n)),r!=null?(this._sourcesContents||(this._sourcesContents=Object.create(null)),this._sourcesContents[Ke.toSetString(n)]=r):this._sourcesContents&&(delete this._sourcesContents[Ke.toSetString(n)],Object.keys(this._sourcesContents).length===0&&(this._sourcesContents=null))};Sr.prototype.applySourceMap=function(t,r,n){var o=r;if(r==null){if(t.file==null)throw new Error(`SourceMapGenerator.prototype.applySourceMap requires either an explicit source file, or the source map's "file" property. Both were omitted.`);o=t.file}var i=this._sourceRoot;i!=null&&(o=Ke.relative(i,o));var s=new pp,a=new pp;this._mappings.unsortedForEach(function(l){if(l.source===o&&l.originalLine!=null){var c=t.originalPositionFor({line:l.originalLine,column:l.originalColumn});c.source!=null&&(l.source=c.source,n!=null&&(l.source=Ke.join(n,l.source)),i!=null&&(l.source=Ke.relative(i,l.source)),l.originalLine=c.line,l.originalColumn=c.column,c.name!=null&&(l.name=c.name))}var u=l.source;u!=null&&!s.has(u)&&s.add(u);var f=l.name;f!=null&&!a.has(f)&&a.add(f)},this),this._sources=s,this._names=a,t.sources.forEach(function(l){var c=t.sourceContentFor(l);c!=null&&(n!=null&&(l=Ke.join(n,l)),i!=null&&(l=Ke.relative(i,l)),this.setSourceContent(l,c))},this)};Sr.prototype._validateMapping=function(t,r,n,o){if(r&&typeof r.line!="number"&&typeof r.column!="number"){var i="original.line and original.column are not numbers -- you probably meant to omit the original mapping entirely and only map the generated position. If so, pass null for the original mapping instead of an object with empty or null values.";if(this._ignoreInvalidMapping)return typeof console<"u"&&console.warn&&console.warn(i),!1;throw new Error(i)}if(!(t&&"line"in t&&"column"in t&&t.line>0&&t.column>=0&&!r&&!n&&!o)){if(t&&"line"in t&&"column"in t&&r&&"line"in r&&"column"in r&&t.line>0&&t.column>=0&&r.line>0&&r.column>=0&&n)return;var i="Invalid mapping: "+JSON.stringify({generated:t,source:n,original:r,name:o});if(this._ignoreInvalidMapping)return typeof console<"u"&&console.warn&&console.warn(i),!1;throw new Error(i)}};Sr.prototype._serializeMappings=function(){for(var t=0,r=1,n=0,o=0,i=0,s=0,a="",l,c,u,f,m=this._mappings.toArray(),d=0,p=m.length;d<p;d++){if(c=m[d],l="",c.generatedLine!==r)for(t=0;c.generatedLine!==r;)l+=";",r++;else if(d>0){if(!Ke.compareByGeneratedPositionsInflated(c,m[d-1]))continue;l+=","}l+=hu.encode(c.generatedColumn-t),t=c.generatedColumn,c.source!=null&&(f=this._sources.indexOf(c.source),l+=hu.encode(f-s),s=f,l+=hu.encode(c.originalLine-1-o),o=c.originalLine-1,l+=hu.encode(c.originalColumn-n),n=c.originalColumn,c.name!=null&&(u=this._names.indexOf(c.name),l+=hu.encode(u-i),i=u)),a+=l}return a};Sr.prototype._generateSourcesContent=function(t,r){return t.map(function(n){if(!this._sourcesContents)return null;r!=null&&(n=Ke.relative(r,n));var o=Ke.toSetString(n);return Object.prototype.hasOwnProperty.call(this._sourcesContents,o)?this._sourcesContents[o]:null},this)};Sr.prototype.toJSON=function(){var t={version:this._version,sources:this._sources.toArray(),names:this._names.toArray(),mappings:this._serializeMappings()};return this._file!=null&&(t.file=this._file),this._sourceRoot!=null&&(t.sourceRoot=this._sourceRoot),this._sourcesContents&&(t.sourcesContent=this._generateSourcesContent(t.sources,t.sourceRoot)),t};Sr.prototype.toString=function(){return JSON.stringify(this.toJSON())};tQ.SourceMapGenerator=Sr});var rQ=ne(Yi=>{Yi.GREATEST_LOWER_BOUND=1;Yi.LEAST_UPPER_BOUND=2;function Jb(e,t,r,n,o,i){var s=Math.floor((t-e)/2)+e,a=o(r,n[s],!0);return a===0?s:a>0?t-s>1?Jb(s,t,r,n,o,i):i==Yi.LEAST_UPPER_BOUND?t<n.length?t:-1:s:s-e>1?Jb(e,s,r,n,o,i):i==Yi.LEAST_UPPER_BOUND?s:e<0?-1:e}Yi.search=function(t,r,n,o){if(r.length===0)return-1;var i=Jb(-1,r.length,t,r,n,o||Yi.GREATEST_LOWER_BOUND);if(i<0)return-1;for(;i-1>=0&&n(r[i],r[i-1],!0)===0;)--i;return i}});var iQ=ne(oQ=>{function sY(e){function t(o,i,s){var a=o[i];o[i]=o[s],o[s]=a}function r(o,i){return Math.round(o+Math.random()*(i-o))}function n(o,i,s,a){if(s<a){var l=r(s,a),c=s-1;t(o,l,a);for(var u=o[a],f=s;f<a;f++)i(o[f],u,!1)<=0&&(c+=1,t(o,c,f));t(o,c+1,f);var m=c+1;n(o,i,s,m-1),n(o,i,m+1,a)}}return n}function aY(e){let t=sY.toString();return new Function(`return ${t}`)()(e)}var nQ=new WeakMap;oQ.quickSort=function(e,t,r=0){let n=nQ.get(t);n===void 0&&(n=aY(t),nQ.set(t,n)),n(e,t,r,e.length-1)}});var cQ=ne(Ap=>{var W=Wa(),Xb=rQ(),qa=zb().ArraySet,cY=Vb(),yu=iQ().quickSort;function Te(e,t){var r=e;return typeof e=="string"&&(r=W.parseSourceMapInput(e)),r.sections!=null?new jr(r,t):new At(r,t)}Te.fromSourceMap=function(e,t){return At.fromSourceMap(e,t)};Te.prototype._version=3;Te.prototype.__generatedMappings=null;Object.defineProperty(Te.prototype,"_generatedMappings",{configurable:!0,enumerable:!0,get:function(){return this.__generatedMappings||this._parseMappings(this._mappings,this.sourceRoot),this.__generatedMappings}});Te.prototype.__originalMappings=null;Object.defineProperty(Te.prototype,"_originalMappings",{configurable:!0,enumerable:!0,get:function(){return this.__originalMappings||this._parseMappings(this._mappings,this.sourceRoot),this.__originalMappings}});Te.prototype._charIsMappingSeparator=function(t,r){var n=t.charAt(r);return n===";"||n===","};Te.prototype._parseMappings=function(t,r){throw new Error("Subclasses must implement _parseMappings")};Te.GENERATED_ORDER=1;Te.ORIGINAL_ORDER=2;Te.GREATEST_LOWER_BOUND=1;Te.LEAST_UPPER_BOUND=2;Te.prototype.eachMapping=function(t,r,n){var o=r||null,i=n||Te.GENERATED_ORDER,s;switch(i){case Te.GENERATED_ORDER:s=this._generatedMappings;break;case Te.ORIGINAL_ORDER:s=this._originalMappings;break;default:throw new Error("Unknown order of iteration.")}for(var a=this.sourceRoot,l=t.bind(o),c=this._names,u=this._sources,f=this._sourceMapURL,m=0,d=s.length;m<d;m++){var p=s[m],h=p.source===null?null:u.at(p.source);h!==null&&(h=W.computeSourceURL(a,h,f)),l({source:h,generatedLine:p.generatedLine,generatedColumn:p.generatedColumn,originalLine:p.originalLine,originalColumn:p.originalColumn,name:p.name===null?null:c.at(p.name)})}};Te.prototype.allGeneratedPositionsFor=function(t){var r=W.getArg(t,"line"),n={source:W.getArg(t,"source"),originalLine:r,originalColumn:W.getArg(t,"column",0)};if(n.source=this._findSourceIndex(n.source),n.source<0)return[];var o=[],i=this._findMapping(n,this._originalMappings,"originalLine","originalColumn",W.compareByOriginalPositions,Xb.LEAST_UPPER_BOUND);if(i>=0){var s=this._originalMappings[i];if(t.column===void 0)for(var a=s.originalLine;s&&s.originalLine===a;)o.push({line:W.getArg(s,"generatedLine",null),column:W.getArg(s,"generatedColumn",null),lastColumn:W.getArg(s,"lastGeneratedColumn",null)}),s=this._originalMappings[++i];else for(var l=s.originalColumn;s&&s.originalLine===r&&s.originalColumn==l;)o.push({line:W.getArg(s,"generatedLine",null),column:W.getArg(s,"generatedColumn",null),lastColumn:W.getArg(s,"lastGeneratedColumn",null)}),s=this._originalMappings[++i]}return o};Ap.SourceMapConsumer=Te;function At(e,t){var r=e;typeof e=="string"&&(r=W.parseSourceMapInput(e));var n=W.getArg(r,"version"),o=W.getArg(r,"sources"),i=W.getArg(r,"names",[]),s=W.getArg(r,"sourceRoot",null),a=W.getArg(r,"sourcesContent",null),l=W.getArg(r,"mappings"),c=W.getArg(r,"file",null);if(n!=this._version)throw new Error("Unsupported version: "+n);s&&(s=W.normalize(s)),o=o.map(String).map(W.normalize).map(function(u){return s&&W.isAbsolute(s)&&W.isAbsolute(u)?W.relative(s,u):u}),this._names=qa.fromArray(i.map(String),!0),this._sources=qa.fromArray(o,!0),this._absoluteSources=this._sources.toArray().map(function(u){return W.computeSourceURL(s,u,t)}),this.sourceRoot=s,this.sourcesContent=a,this._mappings=l,this._sourceMapURL=t,this.file=c}At.prototype=Object.create(Te.prototype);At.prototype.consumer=Te;At.prototype._findSourceIndex=function(e){var t=e;if(this.sourceRoot!=null&&(t=W.relative(this.sourceRoot,t)),this._sources.has(t))return this._sources.indexOf(t);var r;for(r=0;r<this._absoluteSources.length;++r)if(this._absoluteSources[r]==e)return r;return-1};At.fromSourceMap=function(t,r){var n=Object.create(At.prototype),o=n._names=qa.fromArray(t._names.toArray(),!0),i=n._sources=qa.fromArray(t._sources.toArray(),!0);n.sourceRoot=t._sourceRoot,n.sourcesContent=t._generateSourcesContent(n._sources.toArray(),n.sourceRoot),n.file=t._file,n._sourceMapURL=r,n._absoluteSources=n._sources.toArray().map(function(d){return W.computeSourceURL(n.sourceRoot,d,r)});for(var s=t._mappings.toArray().slice(),a=n.__generatedMappings=[],l=n.__originalMappings=[],c=0,u=s.length;c<u;c++){var f=s[c],m=new aQ;m.generatedLine=f.generatedLine,m.generatedColumn=f.generatedColumn,f.source&&(m.source=i.indexOf(f.source),m.originalLine=f.originalLine,m.originalColumn=f.originalColumn,f.name&&(m.name=o.indexOf(f.name)),l.push(m)),a.push(m)}return yu(n.__originalMappings,W.compareByOriginalPositions),n};At.prototype._version=3;Object.defineProperty(At.prototype,"sources",{get:function(){return this._absoluteSources.slice()}});function aQ(){this.generatedLine=0,this.generatedColumn=0,this.source=null,this.originalLine=null,this.originalColumn=null,this.name=null}var Kb=W.compareByGeneratedPositionsDeflatedNoLine;function sQ(e,t){let r=e.length,n=e.length-t;if(!(n<=1))if(n==2){let o=e[t],i=e[t+1];Kb(o,i)>0&&(e[t]=i,e[t+1]=o)}else if(n<20)for(let o=t;o<r;o++)for(let i=o;i>t;i--){let s=e[i-1],a=e[i];if(Kb(s,a)<=0)break;e[i-1]=a,e[i]=s}else yu(e,Kb,t)}At.prototype._parseMappings=function(t,r){var n=1,o=0,i=0,s=0,a=0,l=0,c=t.length,u=0,f={},m={},d=[],p=[],h,y,b,C,I;let x=0;for(;u<c;)if(t.charAt(u)===";")n++,u++,o=0,sQ(p,x),x=p.length;else if(t.charAt(u)===",")u++;else{for(h=new aQ,h.generatedLine=n,C=u;C<c&&!this._charIsMappingSeparator(t,C);C++);for(y=t.slice(u,C),b=[];u<C;)cY.decode(t,u,m),I=m.value,u=m.rest,b.push(I);if(b.length===2)throw new Error("Found a source, but no line and column");if(b.length===3)throw new Error("Found a source and line, but no column");if(h.generatedColumn=o+b[0],o=h.generatedColumn,b.length>1&&(h.source=a+b[1],a+=b[1],h.originalLine=i+b[2],i=h.originalLine,h.originalLine+=1,h.originalColumn=s+b[3],s=h.originalColumn,b.length>4&&(h.name=l+b[4],l+=b[4])),p.push(h),typeof h.originalLine=="number"){let v=h.source;for(;d.length<=v;)d.push(null);d[v]===null&&(d[v]=[]),d[v].push(h)}}sQ(p,x),this.__generatedMappings=p;for(var S=0;S<d.length;S++)d[S]!=null&&yu(d[S],W.compareByOriginalPositionsNoSource);this.__originalMappings=[].concat(...d)};At.prototype._findMapping=function(t,r,n,o,i,s){if(t[n]<=0)throw new TypeError("Line must be greater than or equal to 1, got "+t[n]);if(t[o]<0)throw new TypeError("Column must be greater than or equal to 0, got "+t[o]);return Xb.search(t,r,i,s)};At.prototype.computeColumnSpans=function(){for(var t=0;t<this._generatedMappings.length;++t){var r=this._generatedMappings[t];if(t+1<this._generatedMappings.length){var n=this._generatedMappings[t+1];if(r.generatedLine===n.generatedLine){r.lastGeneratedColumn=n.generatedColumn-1;continue}}r.lastGeneratedColumn=1/0}};At.prototype.originalPositionFor=function(t){var r={generatedLine:W.getArg(t,"line"),generatedColumn:W.getArg(t,"column")},n=this._findMapping(r,this._generatedMappings,"generatedLine","generatedColumn",W.compareByGeneratedPositionsDeflated,W.getArg(t,"bias",Te.GREATEST_LOWER_BOUND));if(n>=0){var o=this._generatedMappings[n];if(o.generatedLine===r.generatedLine){var i=W.getArg(o,"source",null);i!==null&&(i=this._sources.at(i),i=W.computeSourceURL(this.sourceRoot,i,this._sourceMapURL));var s=W.getArg(o,"name",null);return s!==null&&(s=this._names.at(s)),{source:i,line:W.getArg(o,"originalLine",null),column:W.getArg(o,"originalColumn",null),name:s}}}return{source:null,line:null,column:null,name:null}};At.prototype.hasContentsOfAllSources=function(){return this.sourcesContent?this.sourcesContent.length>=this._sources.size()&&!this.sourcesContent.some(function(t){return t==null}):!1};At.prototype.sourceContentFor=function(t,r){if(!this.sourcesContent)return null;var n=this._findSourceIndex(t);if(n>=0)return this.sourcesContent[n];var o=t;this.sourceRoot!=null&&(o=W.relative(this.sourceRoot,o));var i;if(this.sourceRoot!=null&&(i=W.urlParse(this.sourceRoot))){var s=o.replace(/^file:\/\//,"");if(i.scheme=="file"&&this._sources.has(s))return this.sourcesContent[this._sources.indexOf(s)];if((!i.path||i.path=="/")&&this._sources.has("/"+o))return this.sourcesContent[this._sources.indexOf("/"+o)]}if(r)return null;throw new Error('"'+o+'" is not in the SourceMap.')};At.prototype.generatedPositionFor=function(t){var r=W.getArg(t,"source");if(r=this._findSourceIndex(r),r<0)return{line:null,column:null,lastColumn:null};var n={source:r,originalLine:W.getArg(t,"line"),originalColumn:W.getArg(t,"column")},o=this._findMapping(n,this._originalMappings,"originalLine","originalColumn",W.compareByOriginalPositions,W.getArg(t,"bias",Te.GREATEST_LOWER_BOUND));if(o>=0){var i=this._originalMappings[o];if(i.source===n.source)return{line:W.getArg(i,"generatedLine",null),column:W.getArg(i,"generatedColumn",null),lastColumn:W.getArg(i,"lastGeneratedColumn",null)}}return{line:null,column:null,lastColumn:null}};Ap.BasicSourceMapConsumer=At;function jr(e,t){var r=e;typeof e=="string"&&(r=W.parseSourceMapInput(e));var n=W.getArg(r,"version"),o=W.getArg(r,"sections");if(n!=this._version)throw new Error("Unsupported version: "+n);this._sources=new qa,this._names=new qa;var i={line:-1,column:0};this._sections=o.map(function(s){if(s.url)throw new Error("Support for url field in sections not implemented.");var a=W.getArg(s,"offset"),l=W.getArg(a,"line"),c=W.getArg(a,"column");if(l<i.line||l===i.line&&c<i.column)throw new Error("Section offsets must be ordered and non-overlapping.");return i=a,{generatedOffset:{generatedLine:l+1,generatedColumn:c+1},consumer:new Te(W.getArg(s,"map"),t)}})}jr.prototype=Object.create(Te.prototype);jr.prototype.constructor=Te;jr.prototype._version=3;Object.defineProperty(jr.prototype,"sources",{get:function(){for(var e=[],t=0;t<this._sections.length;t++)for(var r=0;r<this._sections[t].consumer.sources.length;r++)e.push(this._sections[t].consumer.sources[r]);return e}});jr.prototype.originalPositionFor=function(t){var r={generatedLine:W.getArg(t,"line"),generatedColumn:W.getArg(t,"column")},n=Xb.search(r,this._sections,function(i,s){var a=i.generatedLine-s.generatedOffset.generatedLine;return a||i.generatedColumn-s.generatedOffset.generatedColumn}),o=this._sections[n];return o?o.consumer.originalPositionFor({line:r.generatedLine-(o.generatedOffset.generatedLine-1),column:r.generatedColumn-(o.generatedOffset.generatedLine===r.generatedLine?o.generatedOffset.generatedColumn-1:0),bias:t.bias}):{source:null,line:null,column:null,name:null}};jr.prototype.hasContentsOfAllSources=function(){return this._sections.every(function(t){return t.consumer.hasContentsOfAllSources()})};jr.prototype.sourceContentFor=function(t,r){for(var n=0;n<this._sections.length;n++){var o=this._sections[n],i=o.consumer.sourceContentFor(t,!0);if(i||i==="")return i}if(r)return null;throw new Error('"'+t+'" is not in the SourceMap.')};jr.prototype.generatedPositionFor=function(t){for(var r=0;r<this._sections.length;r++){var n=this._sections[r];if(n.consumer._findSourceIndex(W.getArg(t,"source"))!==-1){var o=n.consumer.generatedPositionFor(t);if(o){var 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if(d>0){if(!Je.compareByGeneratedPositionsInflated(c,m[d-1]))continue;l+=","}l+=hu.encode(c.generatedColumn-t),t=c.generatedColumn,c.source!=null&&(f=this._sources.indexOf(c.source),l+=hu.encode(f-s),s=f,l+=hu.encode(c.originalLine-1-o),o=c.originalLine-1,l+=hu.encode(c.originalColumn-n),n=c.originalColumn,c.name!=null&&(u=this._names.indexOf(c.name),l+=hu.encode(u-i),i=u)),a+=l}return a};Sr.prototype._generateSourcesContent=function(t,r){return t.map(function(n){if(!this._sourcesContents)return null;r!=null&&(n=Je.relative(r,n));var o=Je.toSetString(n);return Object.prototype.hasOwnProperty.call(this._sourcesContents,o)?this._sourcesContents[o]:null},this)};Sr.prototype.toJSON=function(){var t={version:this._version,sources:this._sources.toArray(),names:this._names.toArray(),mappings:this._serializeMappings()};return this._file!=null&&(t.file=this._file),this._sourceRoot!=null&&(t.sourceRoot=this._sourceRoot),this._sourcesContents&&(t.sourcesContent=this._generateSourcesContent(t.sources,t.sourceRoot)),t};Sr.prototype.toString=function(){return JSON.stringify(this.toJSON())};uQ.SourceMapGenerator=Sr});var fQ=ne(Yi=>{Yi.GREATEST_LOWER_BOUND=1;Yi.LEAST_UPPER_BOUND=2;function Zb(e,t,r,n,o,i){var s=Math.floor((t-e)/2)+e,a=o(r,n[s],!0);return a===0?s:a>0?t-s>1?Zb(s,t,r,n,o,i):i==Yi.LEAST_UPPER_BOUND?t<n.length?t:-1:s:s-e>1?Zb(e,s,r,n,o,i):i==Yi.LEAST_UPPER_BOUND?s:e<0?-1:e}Yi.search=function(t,r,n,o){if(r.length===0)return-1;var i=Zb(-1,r.length,t,r,n,o||Yi.GREATEST_LOWER_BOUND);if(i<0)return-1;for(;i-1>=0&&n(r[i],r[i-1],!0)===0;)--i;return i}});var pQ=ne(mQ=>{function bY(e){function t(o,i,s){var a=o[i];o[i]=o[s],o[s]=a}function r(o,i){return Math.round(o+Math.random()*(i-o))}function n(o,i,s,a){if(s<a){var l=r(s,a),c=s-1;t(o,l,a);for(var u=o[a],f=s;f<a;f++)i(o[f],u,!1)<=0&&(c+=1,t(o,c,f));t(o,c+1,f);var m=c+1;n(o,i,s,m-1),n(o,i,m+1,a)}}return n}function CY(e){let t=bY.toString();return new Function(`return ${t}`)()(e)}var dQ=new WeakMap;mQ.quickSort=function(e,t,r=0){let n=dQ.get(t);n===void 0&&(n=CY(t),dQ.set(t,n)),n(e,t,r,e.length-1)}});var hQ=ne(Ap=>{var W=Wa(),tC=fQ(),qa=Kb().ArraySet,xY=qb(),yu=pQ().quickSort;function Te(e,t){var r=e;return typeof e=="string"&&(r=W.parseSourceMapInput(e)),r.sections!=null?new jr(r,t):new At(r,t)}Te.fromSourceMap=function(e,t){return At.fromSourceMap(e,t)};Te.prototype._version=3;Te.prototype.__generatedMappings=null;Object.defineProperty(Te.prototype,"_generatedMappings",{configurable:!0,enumerable:!0,get:function(){return this.__generatedMappings||this._parseMappings(this._mappings,this.sourceRoot),this.__generatedMappings}});Te.prototype.__originalMappings=null;Object.defineProperty(Te.prototype,"_originalMappings",{configurable:!0,enumerable:!0,get:function(){return this.__originalMappings||this._parseMappings(this._mappings,this.sourceRoot),this.__originalMappings}});Te.prototype._charIsMappingSeparator=function(t,r){var n=t.charAt(r);return n===";"||n===","};Te.prototype._parseMappings=function(t,r){throw new Error("Subclasses must implement _parseMappings")};Te.GENERATED_ORDER=1;Te.ORIGINAL_ORDER=2;Te.GREATEST_LOWER_BOUND=1;Te.LEAST_UPPER_BOUND=2;Te.prototype.eachMapping=function(t,r,n){var o=r||null,i=n||Te.GENERATED_ORDER,s;switch(i){case Te.GENERATED_ORDER:s=this._generatedMappings;break;case Te.ORIGINAL_ORDER:s=this._originalMappings;break;default:throw new Error("Unknown order of iteration.")}for(var a=this.sourceRoot,l=t.bind(o),c=this._names,u=this._sources,f=this._sourceMapURL,m=0,d=s.length;m<d;m++){var p=s[m],h=p.source===null?null:u.at(p.source);h!==null&&(h=W.computeSourceURL(a,h,f)),l({source:h,generatedLine:p.generatedLine,generatedColumn:p.generatedColumn,originalLine:p.originalLine,originalColumn:p.originalColumn,name:p.name===null?null:c.at(p.name)})}};Te.prototype.allGeneratedPositionsFor=function(t){var r=W.getArg(t,"line"),n={source:W.getArg(t,"source"),originalLine:r,originalColumn:W.getArg(t,"column",0)};if(n.source=this._findSourceIndex(n.source),n.source<0)return[];var o=[],i=this._findMapping(n,this._originalMappings,"originalLine","originalColumn",W.compareByOriginalPositions,tC.LEAST_UPPER_BOUND);if(i>=0){var s=this._originalMappings[i];if(t.column===void 0)for(var a=s.originalLine;s&&s.originalLine===a;)o.push({line:W.getArg(s,"generatedLine",null),column:W.getArg(s,"generatedColumn",null),lastColumn:W.getArg(s,"lastGeneratedColumn",null)}),s=this._originalMappings[++i];else for(var l=s.originalColumn;s&&s.originalLine===r&&s.originalColumn==l;)o.push({line:W.getArg(s,"generatedLine",null),column:W.getArg(s,"generatedColumn",null),lastColumn:W.getArg(s,"lastGeneratedColumn",null)}),s=this._originalMappings[++i]}return o};Ap.SourceMapConsumer=Te;function At(e,t){var r=e;typeof e=="string"&&(r=W.parseSourceMapInput(e));var n=W.getArg(r,"version"),o=W.getArg(r,"sources"),i=W.getArg(r,"names",[]),s=W.getArg(r,"sourceRoot",null),a=W.getArg(r,"sourcesContent",null),l=W.getArg(r,"mappings"),c=W.getArg(r,"file",null);if(n!=this._version)throw new Error("Unsupported version: "+n);s&&(s=W.normalize(s)),o=o.map(String).map(W.normalize).map(function(u){return s&&W.isAbsolute(s)&&W.isAbsolute(u)?W.relative(s,u):u}),this._names=qa.fromArray(i.map(String),!0),this._sources=qa.fromArray(o,!0),this._absoluteSources=this._sources.toArray().map(function(u){return W.computeSourceURL(s,u,t)}),this.sourceRoot=s,this.sourcesContent=a,this._mappings=l,this._sourceMapURL=t,this.file=c}At.prototype=Object.create(Te.prototype);At.prototype.consumer=Te;At.prototype._findSourceIndex=function(e){var t=e;if(this.sourceRoot!=null&&(t=W.relative(this.sourceRoot,t)),this._sources.has(t))return this._sources.indexOf(t);var r;for(r=0;r<this._absoluteSources.length;++r)if(this._absoluteSources[r]==e)return r;return-1};At.fromSourceMap=function(t,r){var n=Object.create(At.prototype),o=n._names=qa.fromArray(t._names.toArray(),!0),i=n._sources=qa.fromArray(t._sources.toArray(),!0);n.sourceRoot=t._sourceRoot,n.sourcesContent=t._generateSourcesContent(n._sources.toArray(),n.sourceRoot),n.file=t._file,n._sourceMapURL=r,n._absoluteSources=n._sources.toArray().map(function(d){return W.computeSourceURL(n.sourceRoot,d,r)});for(var s=t._mappings.toArray().slice(),a=n.__generatedMappings=[],l=n.__originalMappings=[],c=0,u=s.length;c<u;c++){var f=s[c],m=new gQ;m.generatedLine=f.generatedLine,m.generatedColumn=f.generatedColumn,f.source&&(m.source=i.indexOf(f.source),m.originalLine=f.originalLine,m.originalColumn=f.originalColumn,f.name&&(m.name=o.indexOf(f.name)),l.push(m)),a.push(m)}return yu(n.__originalMappings,W.compareByOriginalPositions),n};At.prototype._version=3;Object.defineProperty(At.prototype,"sources",{get:function(){return this._absoluteSources.slice()}});function gQ(){this.generatedLine=0,this.generatedColumn=0,this.source=null,this.originalLine=null,this.originalColumn=null,this.name=null}var eC=W.compareByGeneratedPositionsDeflatedNoLine;function AQ(e,t){let r=e.length,n=e.length-t;if(!(n<=1))if(n==2){let o=e[t],i=e[t+1];eC(o,i)>0&&(e[t]=i,e[t+1]=o)}else if(n<20)for(let o=t;o<r;o++)for(let i=o;i>t;i--){let s=e[i-1],a=e[i];if(eC(s,a)<=0)break;e[i-1]=a,e[i]=s}else yu(e,eC,t)}At.prototype._parseMappings=function(t,r){var n=1,o=0,i=0,s=0,a=0,l=0,c=t.length,u=0,f={},m={},d=[],p=[],h,y,b,C,I;let x=0;for(;u<c;)if(t.charAt(u)===";")n++,u++,o=0,AQ(p,x),x=p.length;else if(t.charAt(u)===",")u++;else{for(h=new gQ,h.generatedLine=n,C=u;C<c&&!this._charIsMappingSeparator(t,C);C++);for(y=t.slice(u,C),b=[];u<C;)xY.decode(t,u,m),I=m.value,u=m.rest,b.push(I);if(b.length===2)throw new Error("Found a source, but no line and column");if(b.length===3)throw new Error("Found a source and line, but no column");if(h.generatedColumn=o+b[0],o=h.generatedColumn,b.length>1&&(h.source=a+b[1],a+=b[1],h.originalLine=i+b[2],i=h.originalLine,h.originalLine+=1,h.originalColumn=s+b[3],s=h.originalColumn,b.length>4&&(h.name=l+b[4],l+=b[4])),p.push(h),typeof h.originalLine=="number"){let v=h.source;for(;d.length<=v;)d.push(null);d[v]===null&&(d[v]=[]),d[v].push(h)}}AQ(p,x),this.__generatedMappings=p;for(var S=0;S<d.length;S++)d[S]!=null&&yu(d[S],W.compareByOriginalPositionsNoSource);this.__originalMappings=[].concat(...d)};At.prototype._findMapping=function(t,r,n,o,i,s){if(t[n]<=0)throw new TypeError("Line must be greater than or equal to 1, got "+t[n]);if(t[o]<0)throw new TypeError("Column must be greater than or equal to 0, got "+t[o]);return tC.search(t,r,i,s)};At.prototype.computeColumnSpans=function(){for(var t=0;t<this._generatedMappings.length;++t){var r=this._generatedMappings[t];if(t+1<this._generatedMappings.length){var n=this._generatedMappings[t+1];if(r.generatedLine===n.generatedLine){r.lastGeneratedColumn=n.generatedColumn-1;continue}}r.lastGeneratedColumn=1/0}};At.prototype.originalPositionFor=function(t){var r={generatedLine:W.getArg(t,"line"),generatedColumn:W.getArg(t,"column")},n=this._findMapping(r,this._generatedMappings,"generatedLine","generatedColumn",W.compareByGeneratedPositionsDeflated,W.getArg(t,"bias",Te.GREATEST_LOWER_BOUND));if(n>=0){var o=this._generatedMappings[n];if(o.generatedLine===r.generatedLine){var i=W.getArg(o,"source",null);i!==null&&(i=this._sources.at(i),i=W.computeSourceURL(this.sourceRoot,i,this._sourceMapURL));var s=W.getArg(o,"name",null);return s!==null&&(s=this._names.at(s)),{source:i,line:W.getArg(o,"originalLine",null),column:W.getArg(o,"originalColumn",null),name:s}}}return{source:null,line:null,column:null,name:null}};At.prototype.hasContentsOfAllSources=function(){return this.sourcesContent?this.sourcesContent.length>=this._sources.size()&&!this.sourcesContent.some(function(t){return t==null}):!1};At.prototype.sourceContentFor=function(t,r){if(!this.sourcesContent)return null;var n=this._findSourceIndex(t);if(n>=0)return this.sourcesContent[n];var o=t;this.sourceRoot!=null&&(o=W.relative(this.sourceRoot,o));var i;if(this.sourceRoot!=null&&(i=W.urlParse(this.sourceRoot))){var s=o.replace(/^file:\/\//,"");if(i.scheme=="file"&&this._sources.has(s))return this.sourcesContent[this._sources.indexOf(s)];if((!i.path||i.path=="/")&&this._sources.has("/"+o))return this.sourcesContent[this._sources.indexOf("/"+o)]}if(r)return null;throw new Error('"'+o+'" is not in the SourceMap.')};At.prototype.generatedPositionFor=function(t){var r=W.getArg(t,"source");if(r=this._findSourceIndex(r),r<0)return{line:null,column:null,lastColumn:null};var n={source:r,originalLine:W.getArg(t,"line"),originalColumn:W.getArg(t,"column")},o=this._findMapping(n,this._originalMappings,"originalLine","originalColumn",W.compareByOriginalPositions,W.getArg(t,"bias",Te.GREATEST_LOWER_BOUND));if(o>=0){var i=this._originalMappings[o];if(i.source===n.source)return{line:W.getArg(i,"generatedLine",null),column:W.getArg(i,"generatedColumn",null),lastColumn:W.getArg(i,"lastGeneratedColumn",null)}}return{line:null,column:null,lastColumn:null}};Ap.BasicSourceMapConsumer=At;function jr(e,t){var r=e;typeof e=="string"&&(r=W.parseSourceMapInput(e));var n=W.getArg(r,"version"),o=W.getArg(r,"sections");if(n!=this._version)throw new Error("Unsupported version: "+n);this._sources=new qa,this._names=new qa;var i={line:-1,column:0};this._sections=o.map(function(s){if(s.url)throw new Error("Support for url field in sections not implemented.");var a=W.getArg(s,"offset"),l=W.getArg(a,"line"),c=W.getArg(a,"column");if(l<i.line||l===i.line&&c<i.column)throw new Error("Section offsets must be ordered and non-overlapping.");return i=a,{generatedOffset:{generatedLine:l+1,generatedColumn:c+1},consumer:new Te(W.getArg(s,"map"),t)}})}jr.prototype=Object.create(Te.prototype);jr.prototype.constructor=Te;jr.prototype._version=3;Object.defineProperty(jr.prototype,"sources",{get:function(){for(var e=[],t=0;t<this._sections.length;t++)for(var r=0;r<this._sections[t].consumer.sources.length;r++)e.push(this._sections[t].consumer.sources[r]);return e}});jr.prototype.originalPositionFor=function(t){var r={generatedLine:W.getArg(t,"line"),generatedColumn:W.getArg(t,"column")},n=tC.search(r,this._sections,function(i,s){var a=i.generatedLine-s.generatedOffset.generatedLine;return a||i.generatedColumn-s.generatedOffset.generatedColumn}),o=this._sections[n];return o?o.consumer.originalPositionFor({line:r.generatedLine-(o.generatedOffset.generatedLine-1),column:r.generatedColumn-(o.generatedOffset.generatedLine===r.generatedLine?o.generatedOffset.generatedColumn-1:0),bias:t.bias}):{source:null,line:null,column:null,name:null}};jr.prototype.hasContentsOfAllSources=function(){return this._sections.every(function(t){return t.consumer.hasContentsOfAllSources()})};jr.prototype.sourceContentFor=function(t,r){for(var n=0;n<this._sections.length;n++){var o=this._sections[n],i=o.consumer.sourceContentFor(t,!0);if(i||i==="")return i}if(r)return null;throw new Error('"'+t+'" is not in the SourceMap.')};jr.prototype.generatedPositionFor=function(t){for(var r=0;r<this._sections.length;r++){var n=this._sections[r];if(n.consumer._findSourceIndex(W.getArg(t,"source"))!==-1){var o=n.consumer.generatedPositionFor(t);if(o){var i={line:o.line+(n.generatedOffset.generatedLine-1),column:o.column+(n.generatedOffset.generatedLine===o.line?n.generatedOffset.generatedColumn-1:0)};return i}}}return{line:null,column:null}};jr.prototype._parseMappings=function(t,r){this.__generatedMappings=[],this.__originalMappings=[];for(var n=0;n<this._sections.length;n++)for(var o=this._sections[n],i=o.consumer._generatedMappings,s=0;s<i.length;s++){var a=i[s],l=o.consumer._sources.at(a.source);l!==null&&(l=W.computeSourceURL(o.consumer.sourceRoot,l,this._sourceMapURL)),this._sources.add(l),l=this._sources.indexOf(l);var c=null;a.name&&(c=o.consumer._names.at(a.name),this._names.add(c),c=this._names.indexOf(c));var u={source:l,generatedLine:a.generatedLine+(o.generatedOffset.generatedLine-1),generatedColumn:a.generatedColumn+(o.generatedOffset.generatedLine===a.generatedLine?o.generatedOffset.generatedColumn-1:0),originalLine:a.originalLine,originalColumn:a.originalColumn,name:c};this.__generatedMappings.push(u),typeof u.originalLine=="number"&&this.__originalMappings.push(u)}yu(this.__generatedMappings,W.compareByGeneratedPositionsDeflated),yu(this.__originalMappings,W.compareByOriginalPositions)};Ap.IndexedSourceMapConsumer=jr});var bQ=ne(yQ=>{var EY=Xb().SourceMapGenerator,gp=Wa(),wY=/(\r?\n)/,SY=10,za="$$$isSourceNode$$$";function or(e,t,r,n,o){this.children=[],this.sourceContents={},this.line=e??null,this.column=t??null,this.source=r??null,this.name=o??null,this[za]=!0,n!=null&&this.add(n)}or.fromStringWithSourceMap=function(t,r,n){var o=new or,i=t.split(wY),s=0,a=function(){var m=p(),d=p()||"";return m+d;function p(){return s<i.length?i[s++]:void 0}},l=1,c=0,u=null;return r.eachMapping(function(m){if(u!==null)if(l<m.generatedLine)f(u,a()),l++,c=0;else{var d=i[s]||"",p=d.substr(0,m.generatedColumn-c);i[s]=d.substr(m.generatedColumn-c),c=m.generatedColumn,f(u,p),u=m;return}for(;l<m.generatedLine;)o.add(a()),l++;if(c<m.generatedColumn){var d=i[s]||"";o.add(d.substr(0,m.generatedColumn)),i[s]=d.substr(m.generatedColumn),c=m.generatedColumn}u=m},this),s<i.length&&(u&&f(u,a()),o.add(i.splice(s).join(""))),r.sources.forEach(function(m){var d=r.sourceContentFor(m);d!=null&&(n!=null&&(m=gp.join(n,m)),o.setSourceContent(m,d))}),o;function f(m,d){if(m===null||m.source===void 0)o.add(d);else{var p=n?gp.join(n,m.source):m.source;o.add(new or(m.originalLine,m.originalColumn,p,d,m.name))}}};or.prototype.add=function(t){if(Array.isArray(t))t.forEach(function(r){this.add(r)},this);else if(t[za]||typeof t=="string")t&&this.children.push(t);else throw new TypeError("Expected a SourceNode, string, or an array of SourceNodes and strings. Got "+t);return this};or.prototype.prepend=function(t){if(Array.isArray(t))for(var r=t.length-1;r>=0;r--)this.prepend(t[r]);else if(t[za]||typeof t=="string")this.children.unshift(t);else throw new TypeError("Expected a SourceNode, string, or an array of SourceNodes and strings. Got "+t);return this};or.prototype.walk=function(t){for(var r,n=0,o=this.children.length;n<o;n++)r=this.children[n],r[za]?r.walk(t):r!==""&&t(r,{source:this.source,line:this.line,column:this.column,name:this.name})};or.prototype.join=function(t){var r,n,o=this.children.length;if(o>0){for(r=[],n=0;n<o-1;n++)r.push(this.children[n]),r.push(t);r.push(this.children[n]),this.children=r}return this};or.prototype.replaceRight=function(t,r){var n=this.children[this.children.length-1];return n[za]?n.replaceRight(t,r):typeof n=="string"?this.children[this.children.length-1]=n.replace(t,r):this.children.push("".replace(t,r)),this};or.prototype.setSourceContent=function(t,r){this.sourceContents[gp.toSetString(t)]=r};or.prototype.walkSourceContents=function(t){for(var r=0,n=this.children.length;r<n;r++)this.children[r][za]&&this.children[r].walkSourceContents(t);for(var o=Object.keys(this.sourceContents),r=0,n=o.length;r<n;r++)t(gp.fromSetString(o[r]),this.sourceContents[o[r]])};or.prototype.toString=function(){var t="";return this.walk(function(r){t+=r}),t};or.prototype.toStringWithSourceMap=function(t){var r={code:"",line:1,column:0},n=new EY(t),o=!1,i=null,s=null,a=null,l=null;return this.walk(function(c,u){r.code+=c,u.source!==null&&u.line!==null&&u.column!==null?((i!==u.source||s!==u.line||a!==u.column||l!==u.name)&&n.addMapping({source:u.source,original:{line:u.line,column:u.column},generated:{line:r.line,column:r.column},name:u.name}),i=u.source,s=u.line,a=u.column,l=u.name,o=!0):o&&(n.addMapping({generated:{line:r.line,column:r.column}}),i=null,o=!1);for(var f=0,m=c.length;f<m;f++)c.charCodeAt(f)===SY?(r.line++,r.column=0,f+1===m?(i=null,o=!1):o&&n.addMapping({source:u.source,original:{line:u.line,column:u.column},generated:{line:r.line,column:r.column},name:u.name})):r.column++}),this.walkSourceContents(function(c,u){n.setSourceContent(c,u)}),{code:r.code,map:n}};yQ.SourceNode=or});var CQ=ne(hp=>{hp.SourceMapGenerator=Xb().SourceMapGenerator;hp.SourceMapConsumer=hQ().SourceMapConsumer;hp.SourceNode=bQ().SourceNode});async function EQ(e){let t=await fetch(e);if(!t.ok)throw new Error(`HTTP ${t.status} fetching ${e}: ${await t.text()}`);return t.text()}function BY(e,t){let r=[...e.matchAll(IY)].at(-1)?.[1]?.trim(),n;return r&&(n=new URL(r,t),!n.search&&n.protocol!=="data:"&&(n.search=new URL(t).search)),n?.href}async function TY(e){try{let t=BY(await EQ(e),e);return t?new SQ.SourceMapConsumer(JSON.parse(await EQ(t))):void 0}catch{return}}function MY(e){let t=wQ.get(e);if(t)return t;{let r=TY(e);return wQ.set(e,r),r}}function RY(e){let t=vY.exec(e);if(!t)return;let r=t.index,n=e.slice(r).replace(/\)$/,""),o=n.lastIndexOf(":"),i=n.lastIndexOf(":",o-1),s=n.slice(i+1,o),a=n.slice(o+1);return i>0&&xQ.test(s)&&xQ.test(a)?{name:e.slice(0,r).trim().replace(/^at\b\s*/,"").replace(/\s*\($/,"").replace(/@$/,""),uri:n.slice(0,i),line:+s,column:+a}:void 0}async function kY(e){let t=RY(e),r=t?await MY(t.uri):void 0;if(t&&r){let n=r.originalPositionFor({line:t.line,column:t.column-1}),{source:o,line:i,column:s}=n;return o!==null&&i!==null&&s!==null?`${o}:${i}:${s+1}${t.name?` (${t.name})`:""}`:e}else return e}async function IQ(e){return(await Promise.all(e.split(`
39
+ `).map(kY))).join(`
40
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+ `)[Symbol.iterator]();return NK(t)}var pN=A(()=>{dN()});var Wo,YC=A(()=>{pN();rc();Wo=class extends cr{MSA;byName;constructor(t){super(),this.MSA=mN(t),this.byName=new Map;for(let r of this.MSA.alns)this.byName.has(r.id)||this.byName.set(r.id,r.seq)}getMSA(){return this.MSA}getRow(t){return this.byName.get(t)??""}getHeader(){return this.MSA.header}getNames(){return[...this.byName.keys()]}get seqConsensus(){return this.MSA.consensus}}});function AN(e){let t=e.split(`
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  `).map(i=>i.trim()).filter(i=>!!i),r=[],n=[];for(let i of t)if(i.startsWith("SEQ"))r.push(i);else{if(i.startsWith("DATA"))continue;if(i.startsWith("//"))break;n.push(i)}let o=r.map(i=>{let[,s,a,l,c,u,f,m,d]=i.split(" ");return{species:s,protein:a,chr:l,start:+c,end:+u,strand:+f,geneId:m,unknown:d,seq:""}});for(let i of n)for(let s=0;s<r.length;s++)o[s].seq+=i[s];return o}function Mp(e){let t=e.split(`
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- `).map(i=>i.trim()).filter(i=>!!i),r=[],n="";for(let i of t)if(i.startsWith("SEQ"))r.push(i);else{if(i.startsWith("DATA"))continue;if(i.startsWith("//"))break;n=i}let o=r.map(i=>{let[,s,a,l,c,u,f,m,d]=i.split(" ");return{species:s,protein:a,chr:l,start:+c,end:+u,strand:+f,geneId:m,unknown:d}});return{tree:n,seqs:o}}var qC=A(()=>{});var qo,zC=A(()=>{qC();rc();qo=class extends cr{MSA;byName;constructor(t){super(),this.MSA=sN(t),this.byName=new Map;for(let r of this.MSA)this.byName.has(r.protein)||this.byName.set(r.protein,r.seq)}getMSA(){return this.MSA}getRow(t){return this.byName.get(t)??""}getNames(){return[...this.byName.keys()]}}});var zo,YC=A(()=>{rc();Tp();zo=class extends cr{MSA;orderedNames;constructor(t){super();let r=Mu(t),n=Object.create(null),o=Object.create(null);for(let{id:i,seq:s}of r)n[i]=s,i.includes(":")&&(o[i.replaceAll(":","_")]=i);this.orderedNames=r.map(i=>i.id),this.MSA={seqdata:n,colonNormalized:o}}getMSA(){return this.MSA}getNames(){return this.orderedNames}getRow(t){return this.MSA.seqdata[t]??this.MSA.seqdata[this.MSA.colonNormalized[t]??""]??""}}});function rs(e){return wm(e,{postParenNumeric:"name"})}var JC=A(()=>{Cy()});function aN(){return{gf:Object.create(null),gc:Object.create(null),gs:Object.create(null),gr:Object.create(null),seqname:[],seqdata:Object.create(null)}}function Ru(e,t){if(e)return e;if(t)throw new Error("No format header: # STOCKHOLM 1.0");return aN()}function ku(e){return cN.test(e)}function lN(e,t){let r=t??{},n=[],o=null,i=!1,s=e.split(`
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54
55
  UniProt/Swiss-Prot|P26898|IL2RA_SHEEP MEPSLLMWRFFVFIVVPGCVTEACHDDPPSLRNA----------MFKVLRYE----VGTM
55
56
  UniProt/Swiss-Prot|P01590|IL2RA_MOUSE MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNA----------TFKALSYK----NGTI
56
57
  UniProt/Swiss-Prot|P41690|IL2RA_FELCA MEPSLLLWGILTFVVVHGHVTELCDENPPDIQHA----------TFKALTYK----TGTM
@@ -63,7 +64,7 @@ UniProt/Swiss-Prot|Q8BZM1|GLMN_MOUSE PLPLRSLLFLQLPLLGVGLNP----------------
63
64
  UniProt/Swiss-Prot|P36835|IL2_CAPHI -----------LLGVGLNPKFLTP------------------------------------
64
65
  UniProt/Swiss-Prot|Q7JFM4|IL2_AOTVO MLKPPLPLRSLLFLQLPLLGVGLNPKFLTPSGNEDIGGKPGTGGDFFLTSTPAGTLDVST
65
66
  UniProt/Swiss-Prot|Q29416|IL2_CANFA --------------LFLQLSLLG-------------------------------------
66
- `,D5=`CLUSTAL O(1.2.4) multiple sequence alignment
67
+ `,$5=`CLUSTAL O(1.2.4) multiple sequence alignment
67
68
 
68
69
 
69
70
  sp|P69905|HBA_HUMAN MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG 60
@@ -79,21 +80,22 @@ sp|P13786|HBAZ_CAPHI SKVVAAVGDAVKSIDNVTSALSKLSELHAYVLRVDPVNFKFLSHCLLVTLASHF
79
80
  sp|P69905|HBA_HUMAN AVHASLDKFLASVSTVLTSKYR 142
80
81
  sp|P01942|HBA_MOUSE AVHASLDKFLASVSTVLTSKYR 142
81
82
  sp|P13786|HBAZ_CAPHI DAHAAWDKFLSIVSGVLTEKYR 142
82
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j.types.compose(IO(),MO(),BO(),j.types.model("MsaView",{id:fs.ElementId,showDomains:re(j.types.boolean,!0),showDomainLegend:re(j.types.boolean,!0),hideGaps:re(j.types.boolean,!0),allowedGappyness:re(j.types.number,100),subFeatureRows:re(j.types.boolean,!1),type:j.types.literal("MsaView"),drawMsaLetters:re(j.types.boolean,wB),scrollZoom:re(j.types.boolean,SB),scrollZoomAxis:re(j.types.enumeration("ScrollZoomAxis",[...IB]),vB),height:re(j.types.number,550),rowHeight:re(j.types.number,16),scrollY:re(j.types.number,0),scrollX:re(j.types.number,0),colWidth:re(j.types.number,12),treeFilehandle:j.types.maybe(fs.FileLocation),msaFilehandle:j.types.maybe(fs.FileLocation),treeMetadataFilehandle:j.types.maybe(fs.FileLocation),gffFilehandle:j.types.maybe(fs.FileLocation),currentAlignment:re(j.types.number,0),collapsed:re(j.types.array(j.types.string),[]),showOnly:j.types.maybe(j.types.string),turnedOffTracks:re(j.types.map(j.types.boolean),{}),trackHeights:re(j.types.map(j.types.number),{}),columnTracks:re(j.types.array(j.types.frozen()),[]),residueMappings:re(j.types.array(j.types.frozen()),[]),data:j.types.optional(EO(),{}),turnedOffFeatures:re(j.types.map(j.types.boolean),{}),relativeTo:j.types.maybe(j.types.string),highlightColumns:j.types.frozen(),highlights:re(j.types.array(j.types.frozen()),[]),clades:re(j.types.array(j.types.frozen()),[]),encodings:re(j.types.array(j.types.frozen()),[]),rowPanels:re(j.types.array(j.types.frozen()),[])})).volatile(()=>({headerHeight:0,hideHeader:!1,status:void 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0,warnings:[],resetCount:0,hostCarriesData:!1,annotations:[]})).actions(e=>({drawRelativeTo(t){e.relativeTo=t},setHideGaps(t){e.hideGaps=t},setAllowedGappyness(t){e.allowedGappyness=t},setLoadingMSA(t){e.loadingMSA=t},setLoadingTree(t){e.loadingTree=t},setWidth(t){e.volatileWidth=t},setHighResScaleFactor(t){e.highResScaleFactor=t},setHeight(t){e.height=t},setError(t){e.error=t},addWarning(t){e.warnings.includes(t)||(e.warnings=[...e.warnings,t])},clearWarnings(){e.warnings=[]},setHostCarriesData(t){e.hostCarriesData=t},setMousePos(t,r){e.mouseCol=t,e.mouseRow=r},setHighlightedColumns(t){e.highlightedColumns=t},setHighlights(t){e.highlights.replace(t)},setClades(t){e.clades.replace(t)},applyHighlight(t,r){e.transientHighlights={...e.transientHighlights,[t]:r}},clearHighlight(t){if(t in e.transientHighlights){let{[t]:r,...n}=e.transientHighlights;e.transientHighlights=n}},setShowDomains(t){e.showDomains=t},setShowDomainLegend(t){e.showDomainLegend=t},setSubFeatureRows(t){e.subFeatureRows=t},setMouseClickPos(t,r){e.mouseClickCol=t,e.mouseClickRow=r},setRowHeight(t){e.rowHeight=t},setColWidth(t){e.colWidth=t},setCurrentAlignment(t){t!==e.currentAlignment&&(0,it.transaction)(()=>{e.currentAlignment=t,e.collapsed.clear(),this.setShowOnly(void 0),this.drawRelativeTo(void 0),e.scrollX=0,e.scrollY=0})},toggleCollapsed(t){e.collapsed.includes(t)?e.collapsed.remove(t):e.collapsed.push(t)},setShowOnly(t){e.showOnly=t},setData(t){e.data=(0,j.cast)(t)},setMSAFilehandle(t){e.msaFilehandle=t},setTreeFilehandle(t){e.treeFilehandle=t},setTreeMetadataFilehandle(t){e.treeMetadataFilehandle=t},setGFFFilehandle(t){e.gffFilehandle=t},setMSA(t){e.data.setMSA(t)},setTree(t){e.data.setTree(t)},setTreeMetadata(t){e.data.setTreeMetadata(t)},setGFF(t){e.data.setGFF(t)}})).views(e=>({get hideGapsEffective(){return e.hideGaps&&(e.collapsed.length>0||e.allowedGappyness<100)},get realAllowedGappyness(){return this.hideGapsEffective?e.allowedGappyness:100},get actuallyShowDomains(){return e.showDomains&&e.annotations.length>0},get hostRestoresData(){return e.hostCarriesData},get viewInitialized(){return e.volatileWidth!==void 0},get width(){if(e.volatileWidth===void 0)throw new Error("not initialized");return e.volatileWidth}})).views(e=>({get colorScheme(){return Bu[e.colorSchemeName]??Bu[zd]},get header(){return this.MSA?.getHeader()??{}},get alignmentNames(){return this.MSA?.alignmentNames??[]},get noTree(){return!!this.tree.noTree},get noDomains(){return e.annotations.length===0},get unshareableData(){if(e.hostRestoresData)return[];let{data:t}=e,r=C3(e.columnTracks).filter(n=>n>xa).reduce((n,o)=>n+o,0);return[["alignment",t.msa,e.msaFilehandle],["tree",t.tree,e.treeFilehandle],["annotations",t.gff,e.gffFilehandle],["row 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resolvedClades(){return e.clades.length===0?f3:d3(e.clades,xy(this.tree,t=>t.children),this.rowNamesSet)},get cladeGutterWidth(){return BT({clades:this.resolvedClades,rowHeight:e.rowHeight,fontSize:this.fontSize})},get mouseOverRowName(){let{mouseRow:t}=e;return t===void 0?void 0:this.leaves[t]?.data.name},get hoveredInsertion(){let{mouseCol:t,mouseRow:r}=e;if(t!==void 0&&r!==void 0){let n=this.leaves[r]?.data.name;if(n){let o=this.insertionPositions.get(n)?.find(i=>i.pos===t);if(o)return{rowName:n,col:t,letters:o.letters}}}},get root(){return m3(this.tree,e.collapsed,e.showOnly)},get treeOverviewHeight(){return e.showTreeOverview?e.overviewHeight:0},get treeOverviewLayout(){if(!e.showTreeOverview)return;let t=m3(this.tree,e.collapsed),r=Ur(t).length;Ey(t,r,1);let n=Math.max(t.data.length||0,0),o=wy(t)-n;return Sy(t,-n,o?1/o:0),{root:t,numTips:r,maxDepthToLeaf:Ba(t),showBranchLen:e.showBranchLen&&o>0}},get treeOverviewClades(){let t=this.treeOverviewLayout;if(!t||e.clades.length===0)return f3;let r=new Map(Ur(t.root).map((n,o)=>[n.data.name,o]));return d3(e.clades,t.root,r)},get treeOverviewFocusRows(){let t=this.treeOverviewLayout;if(!t||!e.showOnly)return;let r=Fi(t.root,n=>n.data.id===e.showOnly);return r?p3(r):void 0},treeOverviewHit(t){let r=this.treeOverviewLayout;if(!r)return;let{root:n,numTips:o}=r,i=o/e.overviewHeight,s=(0,fe.clamp)(Math.floor(t*i),0,o-1),a=(0,fe.clamp)(Math.ceil((t+1)*i)-1,s,o-1),l=vm(n,s+.5,a+.5);for(;!l.children&&l.parent;)l=l.parent;return l===n?void 0:{id:l.data.id,rows:p3(l)}},get rowPanelsWidth(){return(0,fe.sum)(e.rowPanels.map(t=>i3(t,e.rowHeight)))},get rowPanelsHeaderHeight(){return e.rowPanels.length>0?Jd:0},get msaAreaWidth(){return e.width-e.treeAreaWidth-this.rowPanelsWidth-e.resizeHandleWidth},get treeAreaWidthMinusMargin(){return e.treeAreaWidth-e.marginLeft-this.cladeGutterWidth},get blanks(){let{hideGapsEffective:t,realAllowedGappyness:r}=e;if(!t)return[];let n=this.leaves.map(c=>this.MSA?.getRow(c.data.name)).filter(fe.notEmpty);if(n.length===0)return[];let o=n.reduce((c,u)=>Math.max(c,u.length),0),i=n.length,s=Math.ceil(r/100*i),a=new Uint32Array(o);for(let c=0;c<i;c++){let u=n[c],f=u.length;for(let m=0;m<o;m++)(m>=f||u.charCodeAt(m)-45>>>0<=1)&&a[m]++}let l=[];for(let c=0;c<o;c++)a[c]>=s&&l.push(c);return l},get insertionPositions(){let{blanks:t,rows:r}=this;if(t.length===0)return new Map;let n=new Map;for(let[o,i]of r){let s=aT(t,i);s.length>0&&n.set(o,s)}return n},get rows(){let t=this.MSA;return this.leaves.map(r=>[r.data.name,t?.getRow(r.data.name)]).filter(r=>!!r[1])},get numRows(){return this.leaves.length},seqPosIndex(t){let r=this.MSA;if(!r)return;let n=g3.get(r);n||(n=new Map,g3.set(r,n));let o=n.get(t);if(!o){let i=r.getRow(t);if(!i)return;o=YO(i),n.set(t,o)}return o},get rowMap(){let t=this.MSA;return new Map(t?.getNames().map(r=>[r,t.getRow(r)]).filter(([,r])=>!!r))},get columns(){let t=this.columns2d;return new Map(this.rows.map((r,n)=>[r[0],t[n]]))},get columns2d(){let{hideGapsEffective:t}=e;return this.rows.map(([,r])=>(t?nm(this.blanks,r):r).toUpperCase())},get fontSize(){return Math.min(Math.max(6,e.rowHeight-3),18)},get colStats(){return wT(this.columns2d)},get sequenceType(){let t=this.colStats.lettersPresent,r=new Set(["A","C","G","T","N"]),n=new Set(["A","C","G","U","N"]),o=t.size>0&&[...t].every(s=>r.has(s)),i=t.size>0&&[...t].every(s=>n.has(s));return o?"dna":i?"rna":"amino"},get colConsensus(){let{colStats:t}=this;return Array.from({length:t.numColumns},(r,n)=>{let o=t.total(n),i=0,s="";t.forEachResidue(n,(l,c)=>{c>i&&(i=c,s=gm(l))});let a=o?i/o:0;return{letter:s,color:a>.4?`hsl(240, 30%, ${100*Math.max(1-a/3,.3)}%)`:void 0}})},get colClustalX(){let{colStats:t}=this;return Array.from({length:t.numColumns},(r,n)=>nO(t,n))},get conservation(){let{colStats:t,alphabetMaxBits:r}=this;return Array.from({length:t.numColumns},(n,o)=>{let i=t.total(o),s=t.gapCount(o);return i>s?Math.max(0,1-t.entropy(o)/r)*(1-s/i):0})},get alphabetMaxBits(){return ST(this.sequenceType)},get propertyConservation(){return this.sequenceType==="amino"?HO(this.colStats):[]},get hierarchy(){let t=this.root;Ey(t,this.totalHeight,e.treeWidth);let r=this.rootToTipLength,n=r?e.treeWidth/r:0;return Sy(t,-Math.max(t.data.length||0,0),n),va(t,o=>{o._children&&(o.collapsedTipXFar=(o.len??0)+QT(o)*n)}),t},get totalHeight(){return Ur(this.root).length*e.rowHeight},get leaves(){return Ur(this.hierarchy)},get rootToTipLength(){let t=this.root;return wy(t)-Math.max(t.data.length||0,0)},get maxBranchLength(){return this.rootToTipLength?e.treeWidth:0},get pxPerBranchLength(){let t=this.rootToTipLength;return this.showBranchLenEffective&&t?e.treeWidth/t:0},get maxDepthToLeaf(){return Ba(this.hierarchy)},get allBranchesLength0(){return this.rootToTipLength===0},get showBranchLenEffective(){return this.allBranchesLength0?!1:e.showBranchLen}})).views(e=>({get totalWidth(){return e.numColumns*e.colWidth}})).views(e=>({get showMsaLetters(){return e.drawMsaLetters&&e.rowHeight>=H0&&e.colWidth>=BB&&e.colWidth>e.rowHeight/2},get showTreeText(){return e.drawLabels&&e.rowHeight>=H0}})).views(e=>{let t=new WeakMap;return{get columnTrackContent(){let{MSA:r,blanks:n,hideGapsEffective:o}=e,i=r?.getWidth()??0,s=(c,u,f)=>{if(!c.row)return u;let m=Array.from({length:i},()=>f),d=e.seqPosIndex(c.row);return u.forEach((p,h)=>{let y=d?.[h];y!==void 0&&(m[y]=p)}),m},a=c=>o?sT(n,c):c,l=(c,u)=>{let f=c.row?e.seqPosIndex(c.row)?.[u-1]:u-1;if(!(f===void 0||f<0||f>=i))return o?gc(n,f):f};return new Map(e.columnTracks.map(c=>{if(c.kind==="arc"){let f=(c.arcs??[]).map(m=>{let d=l(c,Math.min(m.start,m.end)),p=l(c,Math.max(m.start,m.end));return d!==void 0&&p!==void 0&&d<p?{start:d,end:p,color:m.color}:void 0}).filter(fe.notEmpty);return[c.id,{arcs:f}]}if(c.kind==="bar"){let f=c.max??1,m=a(s(c,c.values??[],0)).map(d=>Math.min(1,Math.max(0,d/f)));return[c.id,{values:m}]}let u=a(s(c,(c.data??"").split("")," "));return[c.id,{data:u.join("")}]}))},trackHeight(r,n=r,o){return e.trackHeights.get(n)??o??gee[r]??e.rowHeight},columnTrackModel(r){let n=t.get(r);return n||(n=(0,it.computed)(()=>{let o=o3.has(r.kind)?yee(r.id):void 0,i=this.columnTrackContent.get(r.id);return{model:{id:r.id,name:r.name,kind:r.kind,heightKey:o,height:this.trackHeight(r.kind,o,r.height),barColor:r.color,arcColor:r.color,customColorScheme:r.colors,data:i?.data,arcs:i?.arcs},ReactComponent:Yu}}),t.set(r,n)),n.get()},get columnTrackModels(){return e.columnTracks.map(r=>this.columnTrackModel(r))}}}).views(e=>({get labelWidthMap(){let{showTreeText:t,leaves:r}=e;return t?new Map(r.map(n=>{let{name:o}=n.data,i=e.rowDataOf(o)?.genome||o;return[o,Ia(i,U0)]})):new Map},get labelWidthScale(){return e.fontSize/U0},get labelsWidth(){let t=0;for(let r of this.labelWidthMap.values())r>t&&(t=r);return t*this.labelWidthScale},get secondaryStructureConsensus(){return e.MSA?.secondaryStructureConsensus},get seqConsensus(){return e.MSA?.seqConsensus},get secondaryStructureArcs(){let{blanks:t,hideGapsEffective:r}=e,n=this.secondaryStructureConsensus;if(n)return e3(r?nm(t,n):n).map(({start:o,end:i,pseudoknot:s})=>({start:o,end:i,color:s?Cee:bee}))},get adapterTrackModels(){let{MSA:t,hideGapsEffective:r,blanks:n}=e,o=(t?.tracks??[]).filter(s=>!!s.data);if(o.length===0)return[];let{rowHeight:i}=e;return o.map(s=>({model:{...s,kind:"text",data:r?nm(n,s.data):s.data,height:i},ReactComponent:Yu}))},get basePairTrackModels(){let t=this.secondaryStructureArcs;return t?.length?[{model:{id:"base-pairs",name:"Base pairs",kind:"arc",heightKey:"arc",height:e.trackHeight("arc"),arcs:t},ReactComponent:Yu}]:[]},get computedTrackModels(){return[{id:"conservation",name:"Conservation",kind:"bar",barColor:"gray"},...e.sequenceType==="amino"?[{id:"property-conservation",name:"Property conservation",kind:"bar",barColor:"#6a51a3"}]:[],{id:"sequence-logo",name:"Sequence logo",kind:"logo"},{id:"position-ruler",name:"Position",kind:"ruler"}].map(t=>({model:{...t,heightKey:o3.has(t.kind)?t.kind:void 0,height:e.trackHeight(t.kind)},ReactComponent:Yu}))},get tracks(){return[...this.adapterTrackModels,...this.basePairTrackModels,...e.columnTrackModels,...e.numColumns>0?this.computedTrackModels:[]]},get turnedOnTracks(){return this.tracks.filter(t=>!l3(e.turnedOffTracks,t.model.id,t.model.defaultOff))},get showHorizontalScrollbar(){return y3(e.totalWidth,e.msaAreaWidth)},visibleColToRowLetter(t,r){return e.rowMap.get(t)?.[this.visibleColToGlobalCol(r)]},visibleColToSeqPos(t,r){return WO(e.seqPosIndex(t),this.visibleColToGlobalCol(r))},visibleColToSeqPosOneBased(t,r){let n=this.visibleColToSeqPos(t,r);return n!==void 0?n+1:void 0},globalColToVisibleCol(t){let{blanks:r,hideGapsEffective:n}=e;return n?VO(r,t):t},visibleColToGlobalCol(t){let{blanks:r,hideGapsEffective:n}=e;return n?$O(r,t):t},seqPosToGlobalCol(t,r){let n=e.rowMap.get(t);return n===void 0?void 0:e.seqPosIndex(t)?.[r]??(r===0?0:n.length)},seqPosToVisibleCol(t,r){let n=this.seqPosToGlobalCol(t,r);return n===void 0?void 0:this.globalColToVisibleCol(n)},visibleSpan({row:t,start:r,end:n}){let{blanks:o}=e,i=Math.max(1,Math.floor(r)),s=Math.ceil(n),a=i-1,l=s-1;if(t!==void 0){let f=this.seqPosToGlobalCol(t,i-1),m=this.seqPosToGlobalCol(t,s-1);if(f===void 0||m===void 0)return;a=f,l=m}let c=this.globalColToVisibleCol(a)??gc(o,a),u=this.globalColToVisibleCol(l)??gc(o,l)-1;return c<=u?{startCol:c,endCol:u}:void 0},get residueMappingProblems(){let t=[];for(let r of e.residueMappings){let n={row:r.row,structureId:r.structure.id},o=e.seqPosIndex(r.row)?.length;if(o===void 0){t.push({...n,scope:"mapping",reason:"no such row in the alignment"});continue}if(r.rowLength!==void 0&&r.rowLength!==o){t.push({...n,scope:"mapping",reason:`computed against a ${r.rowLength}-residue row; this one has ${o}`});continue}let i=r.segments.find(s=>s.rowEnd>o||s.rowStart<1);if(i){t.push({...n,scope:"mapping",reason:`segment ${i.rowStart}-${i.rowEnd} does not fit a ${o}-residue row`});continue}for(let s of r.segments)h3(s)||t.push({...n,scope:"segment",reason:`segment ${s.rowStart}-${s.rowEnd} maps to ${s.structStart}-${s.structEnd}, which is a different length`})}return t},get usableResidueMappings(){let t=new Set(this.residueMappingProblems.filter(r=>r.scope==="mapping").map(r=>`${r.row}\0${r.structureId}`));return e.residueMappings.filter(r=>!t.has(`${r.row}\0${r.structure.id}`)).map(r=>({...r,segments:r.segments.filter(h3)}))},get mappedStructures(){return this.usableResidueMappings.map(t=>({row:t.row,structure:t.structure}))},structureResidue(t,r,n){let o=[];for(let i of this.usableResidueMappings){if(i.row!==t||n!==void 0&&i.structure.id!==n)continue;let s=i.segments.find(a=>r>=a.rowStart&&r<=a.rowEnd);if(s){let a=s.structStart+(r-s.rowStart);o.push({structure:i.structure,position:a,observed:!Mee(i.unobserved,a)})}}return o.length===1?o[0]:void 0},rowResidue(t,r,n){let o=[];for(let i of this.usableResidueMappings){if(i.structure.id!==t||n!==void 0&&i.structure.asymId!==n)continue;let s=i.segments.find(a=>r>=a.structStart&&r<=a.structEnd);s&&o.push({rowName:i.row,seqPos:s.rowStart+(r-s.structStart)})}return o.length===1?o[0]:void 0}})).views(e=>({get treeScaleBar(){return uO(e.pxPerBranchLength,e.treeAreaWidth-e.marginLeft*2)},get topBandHeight(){return Math.max(e.showHorizontalScrollbar?e.minimapHeight:0,e.rowPanelsHeaderHeight,e.treeOverviewHeight+(this.treeScaleBar?qn:0))},get msaAreaHeight(){return e.height-this.topBandHeight-e.headerHeight-this.totalTrackAreaHeight},get totalTrackAreaHeight(){return(0,fe.sum)(e.turnedOnTracks.map(t=>t.model.height))},get annotationTypes(){let t=new Map;for(let r of e.annotations)t.has(r.accession)||t.set(r.accession,r);return t},get filteredAnnotations(){return e.annotations.filter(t=>!e.turnedOffFeatures.get(t.accession))},get annotationsByRow(){return(0,fe.groupBy)(this.filteredAnnotations,t=>t.id)}})).views(e=>({get showVerticalScrollbar(){return y3(e.totalHeight,e.msaAreaHeight)}})).views(e=>({get dataInitialized(){return!!(e.data.msa||e.data.tree)&&!e.error},get blocksX(){return Zx({viewportSize:e.msaAreaWidth,viewportPos:-e.scrollX,blockSize:e.blockSize,mapSize:e.totalWidth})},get blocksY(){return Zx({viewportSize:e.msaAreaHeight,viewportPos:-e.scrollY,blockSize:e.blockSize,mapSize:e.totalHeight})}})).views(e=>({get blocks2d(){return e.blocksY.flatMap(t=>e.blocksX.map(r=>[r,t]))},get isLoading(){return e.loadingMSA||e.loadingTree},get maxScrollX(){return Math.min(-e.totalWidth+(e.msaAreaWidth-100),0)},get maxScrollY(){return Math.min(-e.totalHeight+e.msaAreaHeight,0)},get wheelZoomAxis(){return e.scrollZoom?e.scrollZoomAxis:"both"}})).actions(e=>({setDrawMsaLetters(t){e.drawMsaLetters=t},setScrollZoom(t){e.scrollZoom=t},setScrollZoomAxis(t){e.scrollZoomAxis=t},setHoveredTreeNode(t){if(t===e.hoveredTreeNode?.nodeId)return;if(!t){e.hoveredTreeNode=void 0;return}let r=Fi(e.hierarchy,n=>n.data.id===t);e.hoveredTreeNode=r?{nodeId:t,descendantNames:Ur(r).map(n=>n.data.name)}:void 0},calculateNeighborJoiningTreeFromMSA(){let t=[...e.rowMap];if(t.length<2)throw new Error("Need at least 2 sequences to build a tree");if(t.length>_i)throw new Error(`Neighbor joining here is capped at ${_i} sequences and this alignment has ${t.length}. Build the tree with FastTree or IQ-TREE and open it alongside the alignment: https://gmod.org/JBrowseMSA/tutorials/protein_family`);this.replaceTree(NO(t))},replaceTree(t){(0,it.transaction)(()=>{e.collapsed.clear(),e.setShowOnly(void 0),e.setTree(t)})},resetZoom(){e.setColWidth(12),e.setRowHeight(16)},zoomOutHorizontal(){e.colWidth=Math.max(Ml,Math.floor(e.colWidth*.75)),e.scrollX=(0,fe.clamp)(e.scrollX,e.maxScrollX,0)},zoomInHorizontal(){e.colWidth=Math.min(ko,Math.ceil(e.colWidth*1.5)),e.scrollX=(0,fe.clamp)(e.scrollX,e.maxScrollX,0)},zoomInVertical(){e.rowHeight=Math.min(ko,Math.ceil(e.rowHeight*1.5))},zoomOutVertical(){e.rowHeight=Math.max(qd,Math.floor(e.rowHeight*.75))},zoomIn(){(0,it.transaction)(()=>{this.zoomInHorizontal(),this.zoomInVertical()})},zoomOut(){(0,it.transaction)(()=>{this.zoomOutHorizontal(),this.zoomOutVertical()})},zoomToPos(t,r,n,o="both"){(0,it.transaction)(()=>{let i=(-e.scrollX+r)/e.colWidth,s=(-e.scrollY+n)/e.rowHeight;o!=="vertical"&&(e.colWidth=(0,fe.clamp)(e.colWidth*t,Ml,ko)),o!=="horizontal"&&(e.rowHeight=(0,fe.clamp)(e.rowHeight*t,qd,ko)),e.scrollX=(0,fe.clamp)(r-i*e.colWidth,e.maxScrollX,0);let a=n-s*e.rowHeight,l=Math.max(0,-e.maxScrollY),c=e.totalHeight-l,u=c>0?(0,fe.clamp)(1-l/c,0,1):1;e.scrollY=(0,fe.clamp)(a*(1-u),e.maxScrollY,0)})},doScrollY(t){this.setScrollY(e.scrollY+t)},setScrollY(t){e.scrollY=(0,fe.clamp)(t,e.maxScrollY,0)},setAnnotations(t){e.annotations=t},setDomains(t){this.setAnnotations(t?Du(t):[])},applyGFFText(t){this.setAnnotations(kp(Rp(t)))},doScrollX(t){this.setScrollX(e.scrollX+t)},setScrollX(t){e.scrollX=(0,fe.clamp)(t,e.maxScrollX,0)},setColumnTracks(t){e.columnTracks.replace(t)},setRowData(t){e.data.setTreeMetadata(JSON.stringify(t))},setEncodings(t){e.encodings.replace(t)},setRowPanels(t){e.rowPanels.replace(t)},setResidueMappings(t){e.residueMappings.replace(t)},toggleTrack(t){let r=e.MSA?.tracks.find(n=>n.id===t)?.defaultOff;e.turnedOffTracks.set(t,!l3(e.turnedOffTracks,t,r))},setStatus(t){e.status=t}})).views(e=>({get verticalScrollbarWidth(){return e.showVerticalScrollbar?20:0},get msaCanvasWidth(){return e.msaAreaWidth-this.verticalScrollbarWidth},cellAt(t,r){let n=e.visibleColToGlobalCol(t),o=r===void 0?void 0:e.leaves[r]?.data.name;return o===void 0?{column:n+1}:{column:n+1,row:o,residue:e.visibleColToSeqPosOneBased(o,t),letter:e.rowMap.get(o)?.[n]}},get hoveredCell(){let{mouseCol:t,mouseRow:r}=e;return t===void 0?void 0:this.cellAt(t,r)},get clickedCell(){let{mouseClickCol:t,mouseClickRow:r}=e;return t===void 0?void 0:this.cellAt(t,r)},get viewport(){let{scrollX:t,colWidth:r,numColumns:n,viewInitialized:o}=e;if(n===0||!o)return;let{xStart:i,xEnd:s}=yr({offsetX:-t,blockWidth:this.msaCanvasWidth,colWidth:r}),a=Math.max(0,Math.min(s,n)-1);return{startColumn:e.visibleColToGlobalCol(Math.min(i,a))+1,endColumn:e.visibleColToGlobalCol(a)+1}},get segmentDomainTypes(){return[...e.annotationTypes.values()].filter(t=>O0.has(t.featureType??"")).toSorted((t,r)=>t.start-r.start)},get categoricalDomainTypes(){return[...e.annotationTypes.values()].filter(t=>!O0.has(t.featureType??""))},get fillPalette(){let t=Object.fromEntries(this.segmentDomainTypes.map((n,o)=>[n.accession,G0[o%G0.length]])),r=xA(this.categoricalDomainTypes.map(n=>n.accession));return{...t,...r}},get featureFillEncoding(){return this.resolvedEncodings.find(t=>t.channel==="featureFill")},get featureColors(){return s3(e.filteredAnnotations,this.featureFillEncoding,this.fillPalette)},get featureLabels(){let t=this.resolvedEncodings.find(r=>r.channel==="featureLabel");return t?a3(e.filteredAnnotations,t.field):void 0},get segmentLabels(){return new Map(this.segmentDomainTypes.map((t,r)=>{let n=/(\d+)\s*$/.exec(t.name);return[t.accession,n?n[1]:`${r+1}`]}))},get visibleDomainTypes(){return this.categoricalDomainTypes.filter(t=>!e.turnedOffFeatures.get(t.accession)).toSorted((t,r)=>t.start-r.start)},get legends(){let{featureFillEncoding:t,fillPalette:r,visibleDomainTypes:n}=this,o=new Map,i=(s,a,l)=>{if(a.length===0)return;let c=s===void 0?"domains":`field:${s}`,u=o.get(c);if(u){let f=new Set(u.entries.map(m=>m.id));u.entries.push(...a.filter(m=>!f.has(m.id)))}else o.set(c,{id:l??(s===void 0?"domains":`rowData-${s}`),title:s??"Domains",entries:[...a]})};e.actuallyShowDomains&&e.numColumns>0&&i(t?.field,t?t.legend:n.map(s=>({id:s.accession,label:s.name,color:r[s.accession]})),"domains");for(let{channel:s,field:a,legend:l}of this.resolvedEncodings)A3.has(s)||i(a,l);for(let{legendTitle:s,legend:a}of this.resolvedRowPanels)i(s,a);return[...o.values()]},get domainUnderline(){return e.actuallyShowDomains&&!e.bgColor&&!e.subFeatureRows&&e.showMsaLetters},get domainBands(){let{blanks:t}=e,r=new Map;for(let[n,o]of Object.entries(e.annotationsByRow)){let i=o.toSorted((s,a)=>ry(a)-ry(s)).map(s=>{let a=e.seqPosToGlobalCol(n,s.start-1),l=e.seqPosToGlobalCol(n,s.end-1);if(a===void 0||l===void 0)return;let c=gc(t,a),u=gc(t,l+1);return u>c?{annotation:s,startCol:c,endCol:u}:void 0}).filter(fe.notEmpty).map((s,a)=>({...s,stackIndex:a}));i.length>0&&r.set(n,zu(i))}return r},get domainBandsByStart(){return new Map([...this.domainBands].map(([t,r])=>[t,r.toSorted((n,o)=>n.startCol-o.startCol)]))},get mouseOverDomains(){let{mouseCol:t}=e,r=e.mouseOverRowName;if(r===void 0||t===void 0)return u3;let n=(this.domainBands.get(r)??[]).filter(o=>t>=o.startCol&&t<o.endCol).map(o=>o.annotation);return n.length>0?n:u3},get referenceRowIndex(){let{relativeTo:t}=e;return t===void 0?void 0:e.rowNamesSet.get(t)},get hoveredRowIndices(){let{hoveredTreeNode:t,rowNamesSet:r}=e;return t?t.descendantNames.map(n=>r.get(n)).filter(fe.notEmpty):[]},get highlightedColumnRuns(){let{highlightedColumns:t}=e,r=[];for(let n of[...t??[]].sort((o,i)=>o-i)){let o=r.at(-1);o&&n===o.end+1?o.end=n:r.push({start:n,end:n})}return r},get resolvedHighlights(){let{rowNamesSet:t,transientHighlights:r}=e;return[...e.highlights,...Object.values(r).flat()].flatMap(({row:o,rows:i,start:s,end:a,label:l,color:c})=>{let u={label:l,color:c};if(i){let m=i.map(d=>t.get(d)).filter(fe.notEmpty);return m.length?[{...u,rowIndices:m}]:[]}if(s===void 0||a===void 0)return[];let f=e.visibleSpan({row:o,start:s,end:a});return f?[{...u,...f,rowIndices:[]}]:[]})},columnStatsAt(t){let{colStats:r,conservation:n,propertyConservation:o}=e;return iO({col:t,colStats:r,conservation:n,propertyConservation:o})},getRowData(t){return{data:e.MSA?.getRowData(t),rowData:e.rowDataOf(t)}},get resolvedEncodings(){let t=Object.values(e.rowData),r=e.filteredAnnotations;return e.encodings.map(n=>({...n,...IA(n.scale,A3.has(n.channel)?r.map(o=>lo(o,n.field)).filter(fe.notEmpty):t.map(o=>o?.[n.field]).filter(fe.notEmpty))}))},get resolvedRowPanels(){let t=Object.entries(e.rowData),{fillPalette:r,featureFillEncoding:n,featureLabels:o}=this,i=e.filteredAnnotations,s=0;return e.rowPanels.map((a,l)=>{let c=i3(a,e.rowHeight),u={id:`rowpanel-${l}`,width:c,offsetX:s};if(s+=c,a.kind==="features"){let p=a.encoding?.color,h=p?Iee(p.field,p.scale,i):n,y=a.encoding?.label,b=a.transform?.find(C=>C.type==="align");return{...u,kind:a.kind,x:a.x,header:a.header??"",field:h?.field,legendTitle:h?.field,spans:See({panel:a,width:c,colWidth:e.colWidth,domainBands:this.domainBands,annotationsByRow:e.annotationsByRow,shifts:b?this.featureAlignShifts.get(b.on):void 0}),colors:s3(i,h,r),labels:y?a3(i,y):o,legend:h?.legend??this.visibleDomainTypes.map(C=>({id:C.accession,label:C.name,color:r[C.accession]}))}}let{colorOf:f,legend:m}=IA(a.scale,t.map(([,p])=>p?.[a.field]).filter(fe.notEmpty)),d=new Map;for(let[p,h]of t){let y=h?.[a.field],b=y===void 0?void 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if(x&16){S=I&65535,x&=15,x&&(p<x&&(d+=_[n++]<<p,p+=8),S+=d&(1<<x)-1,d>>>=x,p-=x),p<15&&(d+=_[n++]<<p,p+=8,d+=_[n++]<<p,p+=8),I=y[d&C];r:for(;;){if(x=I>>>24,d>>>=x,p-=x,x=I>>>16&255,x&16){if(v=I&65535,x&=15,p<x&&(d+=_[n++]<<p,p+=8,p<x&&(d+=_[n++]<<p,p+=8)),v+=d&(1<<x)-1,v>l){e.msg="invalid distance too far back",r.mode=YA;break e}if(d>>>=x,p-=x,x=i-s,v>x){if(x=v-x,x>u&&r.sane){e.msg="invalid distance too far back",r.mode=YA;break e}if(B=0,Q=m,f===0){if(B+=c-x,x<S){S-=x;do M[i++]=m[B++];while(--x);B=i-v,Q=M}}else if(f<x){if(B+=c+f-x,x-=f,x<S){S-=x;do M[i++]=m[B++];while(--x);if(B=0,f<S){x=f,S-=x;do M[i++]=m[B++];while(--x);B=i-v,Q=M}}}else if(B+=f-x,x<S){S-=x;do M[i++]=m[B++];while(--x);B=i-v,Q=M}for(;S>2;)M[i++]=Q[B++],M[i++]=Q[B++],M[i++]=Q[B++],S-=3;S&&(M[i++]=Q[B++],S>1&&(M[i++]=Q[B++]))}else{B=i-v;do M[i++]=M[B++],M[i++]=M[B++],M[i++]=M[B++],S-=3;while(S>2);S&&(M[i++]=M[B++],S>1&&(M[i++]=M[B++]))}}else if((x&64)===0){I=y[(I&65535)+(d&(1<<x)-1)];continue r}else{e.msg="invalid distance code",r.mode=YA;break e}break}}else if((x&64)===0){I=h[(I&65535)+(d&(1<<x)-1)];continue t}else if(x&32){r.mode=nre;break e}else{e.msg="invalid literal/length code",r.mode=YA;break e}break}}while(n<o&&i<a);S=p>>3,n-=S,p-=S<<3,d&=(1<<p)-1,e.next_in=n,e.next_out=i,e.avail_in=n<o?5+(o-n):5-(n-o),e.avail_out=i<a?257+(a-i):257-(i-a),r.hold=d,r.bits=p}var YA,nre,$4=A(()=>{YA=30,nre=12});function Ss(e,t,r,n,o,i,s,a){var l=a.bits,c=0,u=0,f=0,m=0,d=0,p=0,h=0,y=0,b=0,C=0,I,x,S,v,B,Q=null,_=0,M,N=ci(Mc+1),G=ci(Mc+1),E=null,R=0,L,U,J;for(c=0;c<=Mc;c++)N[c]=0;for(u=0;u<n;u++)N[t[r+u]]++;for(d=l,m=Mc;m>=1&&N[m]===0;m--);if(d>m&&(d=m),m===0)return o[i++]=1<<24|64<<16|0,o[i++]=1<<24|64<<16|0,a.bits=1,0;for(f=1;f<m&&N[f]===0;f++);for(d<f&&(d=f),y=1,c=1;c<=Mc;c++)if(y<<=1,y-=N[c],y<0)return-1;if(y>0&&(e===W4||m!==1))return-1;for(G[1]=0,c=1;c<Mc;c++)G[c+1]=G[c]+N[c];for(u=0;u<n;u++)t[r+u]!==0&&(s[G[t[r+u]]++]=u);if(e===W4?(Q=E=s,M=19):e===HE?(Q=ore,_-=257,E=ire,R-=257,M=256):(Q=sre,E=are,M=-1),C=0,u=0,c=f,B=i,p=d,h=0,S=-1,b=1<<d,v=b-1,e===HE&&b>V4||e===q4&&b>j4)return 1;for(;;){L=c-h,s[u]<M?(U=0,J=s[u]):s[u]>M?(U=E[R+s[u]],J=Q[_+s[u]]):(U=96,J=0),I=1<<c-h,x=1<<p,f=x;do x-=I,o[B+(C>>h)+x]=L<<24|U<<16|J|0;while(x!==0);for(I=1<<c-1;C&I;)I>>=1;if(I!==0?(C&=I-1,C+=I):C=0,u++,--N[c]===0){if(c===m)break;c=t[r+s[u]]}if(c>d&&(C&v)!==S){for(h===0&&(h=d),B+=f,p=c-h,y=1<<p;p+h<m&&(y-=N[p+h],!(y<=0));)p++,y<<=1;if(b+=1<<p,e===HE&&b>V4||e===q4&&b>j4)return 1;S=C&v,o[S]=d<<24|p<<16|B-i|0}}return C!==0&&(o[B+C]=c-h<<24|64<<16|0),a.bits=d,0}var Mc,V4,j4,W4,HE,q4,ore,ire,sre,are,z4=A(()=>{cf();Mc=15,V4=852,j4=592,W4=0,HE=1,q4=2,ore=[3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0],ire=[16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78],sre=[1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0],are=[16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64]});function yG(e){return(e>>>24&255)+(e>>>8&65280)+((e&65280)<<8)+((e&255)<<24)}function gre(){this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=ci(320),this.work=ci(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}function hre(e){var t;return!e||!e.state?kr:(t=e.state,e.total_in=e.total_out=t.total=0,e.msg="",t.wrap&&(e.adler=t.wrap&1),t.mode=wG,t.last=0,t.havedict=0,t.dmax=32768,t.head=null,t.hold=0,t.bits=0,t.lencode=t.lendyn=ws(pre),t.distcode=t.distdyn=ws(Are),t.sane=1,t.back=-1,Is)}function yre(e){var t;return!e||!e.state?kr:(t=e.state,t.wsize=0,t.whave=0,t.wnext=0,hre(e))}function bre(e,t){var r,n;return!e||!e.state||(n=e.state,t<0?(r=0,t=-t):(r=(t>>4)+1,t<48&&(t&=15)),t&&(t<8||t>15))?kr:(n.window!==null&&n.wbits!==t&&(n.window=null),n.wrap=r,n.wbits=t,yre(e))}function SG(e,t){var r,n;return e?(n=new gre,e.state=n,n.window=null,r=bre(e,t),r!==Is&&(e.state=null),r):kr}function Cre(e){if(bG){var t;for(jE=ws(512),WE=ws(32),t=0;t<144;)e.lens[t++]=8;for(;t<256;)e.lens[t++]=9;for(;t<280;)e.lens[t++]=7;for(;t<288;)e.lens[t++]=8;for(Ss(CG,e.lens,0,288,jE,0,e.work,{bits:9}),t=0;t<32;)e.lens[t++]=5;Ss(xG,e.lens,0,32,WE,0,e.work,{bits:5}),bG=!1}e.lencode=jE,e.lenbits=9,e.distcode=WE,e.distbits=5}function IG(e,t,r,n){var o,i=e.state;return i.window===null&&(i.wsize=1<<i.wbits,i.wnext=0,i.whave=0,i.window=po(i.wsize)),n>=i.wsize?(Fn(i.window,t,r-i.wsize,i.wsize,0),i.wnext=0,i.whave=i.wsize):(o=i.wsize-i.wnext,o>n&&(o=n),Fn(i.window,t,r-n,o,i.wnext),n-=o,n?(Fn(i.window,t,r-n,n,0),i.wnext=n,i.whave=i.wsize):(i.wnext+=o,i.wnext===i.wsize&&(i.wnext=0),i.whave<i.wsize&&(i.whave+=o))),0}function vG(e,t){var r,n,o,i,s,a,l,c,u,f,m,d,p,h,y=0,b,C,I,x,S,v,B,Q,_=po(4),M,N,G=[16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15];if(!e||!e.state||!e.output||!e.input&&e.avail_in!==0)return kr;r=e.state,r.mode===Ao&&(r.mode=UE),s=e.next_out,o=e.output,l=e.avail_out,i=e.next_in,n=e.input,a=e.avail_in,c=r.hold,u=r.bits,f=a,m=l,Q=Is;e:for(;;)switch(r.mode){case wG:if(r.wrap===0){r.mode=UE;break}for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(r.wrap&2&&c===35615){r.check=0,_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0),c=0,u=0,r.mode=K4;break}if(r.flags=0,r.head&&(r.head.done=!1),!(r.wrap&1)||(((c&255)<<8)+(c>>8))%31){e.msg="incorrect header check",r.mode=Fe;break}if((c&15)!==J4){e.msg="unknown compression method",r.mode=Fe;break}if(c>>>=4,u-=4,B=(c&15)+8,r.wbits===0)r.wbits=B;else if(B>r.wbits){e.msg="invalid window size",r.mode=Fe;break}r.dmax=1<<B,e.adler=r.check=1,r.mode=c&512?iG:Ao,c=0,u=0;break;case K4:for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(r.flags=c,(r.flags&255)!==J4){e.msg="unknown compression method",r.mode=Fe;break}if(r.flags&57344){e.msg="unknown header flags set",r.mode=Fe;break}r.head&&(r.head.text=c>>8&1),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0)),c=0,u=0,r.mode=X4;case X4:for(;u<32;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.head&&(r.head.time=c),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,_[2]=c>>>16&255,_[3]=c>>>24&255,r.check=Rr(r.check,_,4,0)),c=0,u=0,r.mode=Z4;case Z4:for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.head&&(r.head.xflags=c&255,r.head.os=c>>8),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0)),c=0,u=0,r.mode=eG;case eG:if(r.flags&1024){for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.length=c,r.head&&(r.head.extra_len=c),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0)),c=0,u=0}else r.head&&(r.head.extra=null);r.mode=tG;case tG:if(r.flags&1024&&(d=r.length,d>a&&(d=a),d&&(r.head&&(B=r.head.extra_len-r.length,r.head.extra||(r.head.extra=new Array(r.head.extra_len)),Fn(r.head.extra,n,i,d,B)),r.flags&512&&(r.check=Rr(r.check,n,d,i)),a-=d,i+=d,r.length-=d),r.length))break e;r.length=0,r.mode=rG;case rG:if(r.flags&2048){if(a===0)break e;d=0;do B=n[i+d++],r.head&&B&&r.length<65536&&(r.head.name+=String.fromCharCode(B));while(B&&d<a);if(r.flags&512&&(r.check=Rr(r.check,n,d,i)),a-=d,i+=d,B)break e}else r.head&&(r.head.name=null);r.length=0,r.mode=nG;case nG:if(r.flags&4096){if(a===0)break e;d=0;do B=n[i+d++],r.head&&B&&r.length<65536&&(r.head.comment+=String.fromCharCode(B));while(B&&d<a);if(r.flags&512&&(r.check=Rr(r.check,n,d,i)),a-=d,i+=d,B)break e}else r.head&&(r.head.comment=null);r.mode=oG;case oG:if(r.flags&512){for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(c!==(r.check&65535)){e.msg="header crc mismatch",r.mode=Fe;break}c=0,u=0}r.head&&(r.head.hcrc=r.flags>>9&1,r.head.done=!0),e.adler=r.check=0,r.mode=Ao;break;case iG:for(;u<32;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}e.adler=r.check=yG(c),c=0,u=0,r.mode=ZA;case ZA:if(r.havedict===0)return e.next_out=s,e.avail_out=l,e.next_in=i,e.avail_in=a,r.hold=c,r.bits=u,fre;e.adler=r.check=1,r.mode=Ao;case Ao:if(t===lre||t===JA)break e;case UE:if(r.last){c>>>=u&7,u-=u&7,r.mode=VE;break}for(;u<3;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}switch(r.last=c&1,c>>>=1,u-=1,c&3){case 0:r.mode=sG;break;case 1:if(Cre(r),r.mode=KA,t===JA){c>>>=2,u-=2;break e}break;case 2:r.mode=cG;break;case 3:e.msg="invalid block type",r.mode=Fe}c>>>=2,u-=2;break;case sG:for(c>>>=u&7,u-=u&7;u<32;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if((c&65535)!==(c>>>16^65535)){e.msg="invalid stored block lengths",r.mode=Fe;break}if(r.length=c&65535,c=0,u=0,r.mode=$E,t===JA)break e;case $E:r.mode=aG;case aG:if(d=r.length,d){if(d>a&&(d=a),d>l&&(d=l),d===0)break e;Fn(o,n,i,d,s),a-=d,i+=d,l-=d,s+=d,r.length-=d;break}r.mode=Ao;break;case cG:for(;u<14;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(r.nlen=(c&31)+257,c>>>=5,u-=5,r.ndist=(c&31)+1,c>>>=5,u-=5,r.ncode=(c&15)+4,c>>>=4,u-=4,r.nlen>286||r.ndist>30){e.msg="too many length or distance symbols",r.mode=Fe;break}r.have=0,r.mode=lG;case lG:for(;r.have<r.ncode;){for(;u<3;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.lens[G[r.have++]]=c&7,c>>>=3,u-=3}for(;r.have<19;)r.lens[G[r.have++]]=0;if(r.lencode=r.lendyn,r.lenbits=7,M={bits:r.lenbits},Q=Ss(cre,r.lens,0,19,r.lencode,0,r.work,M),r.lenbits=M.bits,Q){e.msg="invalid code lengths set",r.mode=Fe;break}r.have=0,r.mode=uG;case uG:for(;r.have<r.nlen+r.ndist;){for(;y=r.lencode[c&(1<<r.lenbits)-1],b=y>>>24,C=y>>>16&255,I=y&65535,!(b<=u);){if(a===0)break 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j.types.compose(DO(),PO(),LO(),j.types.model("MsaView",{id:fs.ElementId,showDomains:re(j.types.boolean,!0),showDomainLegend:re(j.types.boolean,!0),hideGaps:re(j.types.boolean,!0),allowedGappyness:re(j.types.number,100),subFeatureRows:re(j.types.boolean,!1),type:j.types.literal("MsaView"),drawMsaLetters:re(j.types.boolean,IB),scrollZoom:re(j.types.boolean,vB),scrollZoomAxis:re(j.types.enumeration("ScrollZoomAxis",[...BB]),TB),height:re(j.types.number,550),rowHeight:re(j.types.number,16),scrollY:re(j.types.number,0),scrollX:re(j.types.number,0),colWidth:re(j.types.number,12),treeFilehandle:j.types.maybe(fs.FileLocation),msaFilehandle:j.types.maybe(fs.FileLocation),treeMetadataFilehandle:j.types.maybe(fs.FileLocation),gffFilehandle:j.types.maybe(fs.FileLocation),currentAlignment:re(j.types.number,0),collapsed:re(j.types.array(j.types.string),[]),showOnly:j.types.maybe(j.types.string),turnedOffTracks:re(j.types.map(j.types.boolean),{}),trackHeights:re(j.types.map(j.types.number),{}),columnTracks:re(j.types.array(j.types.frozen()),[]),residueMappings:re(j.types.array(j.types.frozen()),[]),data:j.types.optional(kO(),{}),turnedOffFeatures:re(j.types.map(j.types.boolean),{}),relativeTo:j.types.maybe(j.types.string),highlightColumns:j.types.frozen(),highlights:re(j.types.array(j.types.frozen()),[]),region:j.types.frozen(),clades:re(j.types.array(j.types.frozen()),[]),encodings:re(j.types.array(j.types.frozen()),[]),rowPanels:re(j.types.array(j.types.frozen()),[])})).volatile(()=>({headerHeight:0,hideHeader:!1,status:void 0,highResScaleFactor:typeof window>"u"?1:window.devicePixelRatio,loadingMSA:!1,loadingTree:!1,volatileWidth:void 0,resizeHandleWidth:5,blockSize:500,mouseRow:void 0,mouseCol:void 0,mouseClickRow:void 0,mouseClickCol:void 0,hoveredTreeNode:void 0,highlightedColumns:void 0,transientHighlights:{},minimapHeight:56,marginLeft:20,error:void 0,warnings:[],resetCount:0,hostCarriesData:!1,annotations:[]})).actions(e=>({drawRelativeTo(t){e.relativeTo=t},setHideGaps(t){e.hideGaps=t},setAllowedGappyness(t){e.allowedGappyness=t},setLoadingMSA(t){e.loadingMSA=t},setLoadingTree(t){e.loadingTree=t},setWidth(t){e.volatileWidth=t},setHighResScaleFactor(t){e.highResScaleFactor=t},setHeight(t){e.height=t},setError(t){e.error=t},addWarning(t){e.warnings.includes(t)||(e.warnings=[...e.warnings,t])},clearWarnings(){e.warnings=[]},setHostCarriesData(t){e.hostCarriesData=t},setMousePos(t,r){e.mouseCol=t,e.mouseRow=r},setHighlightedColumns(t){e.highlightedColumns=t},setRegion(t){e.region=t},setHighlights(t){e.highlights.replace(t)},setClades(t){e.clades.replace(t)},applyHighlight(t,r){e.transientHighlights={...e.transientHighlights,[t]:r}},clearHighlight(t){if(t in e.transientHighlights){let{[t]:r,...n}=e.transientHighlights;e.transientHighlights=n}},setShowDomains(t){e.showDomains=t},setShowDomainLegend(t){e.showDomainLegend=t},setSubFeatureRows(t){e.subFeatureRows=t},setMouseClickPos(t,r){e.mouseClickCol=t,e.mouseClickRow=r},setRowHeight(t){e.rowHeight=t},setColWidth(t){e.colWidth=t},setCurrentAlignment(t){t!==e.currentAlignment&&(0,rt.transaction)(()=>{e.currentAlignment=t,e.collapsed.clear(),this.setShowOnly(void 0),this.drawRelativeTo(void 0),e.scrollX=0,e.scrollY=0})},toggleCollapsed(t){e.collapsed.includes(t)?e.collapsed.remove(t):e.collapsed.push(t)},setShowOnly(t){e.showOnly=t},setData(t){e.data=(0,j.cast)(t)},setMSAFilehandle(t){e.msaFilehandle=t},setTreeFilehandle(t){e.treeFilehandle=t},setTreeMetadataFilehandle(t){e.treeMetadataFilehandle=t},setGFFFilehandle(t){e.gffFilehandle=t},setMSA(t){e.data.setMSA(t)},setTree(t){e.data.setTree(t)},setTreeMetadata(t){e.data.setTreeMetadata(t)},setGFF(t){e.data.setGFF(t)}})).views(e=>({get hideGapsEffective(){return e.hideGaps&&(e.collapsed.length>0||e.allowedGappyness<100)},get realAllowedGappyness(){return this.hideGapsEffective?e.allowedGappyness:100},get actuallyShowDomains(){return e.showDomains&&e.annotations.length>0},get hostRestoresData(){return e.hostCarriesData},get viewInitialized(){return e.volatileWidth!==void 0},get width(){if(e.volatileWidth===void 0)throw new Error("not initialized");return e.volatileWidth}})).views(e=>({get colorScheme(){return Bu[e.colorSchemeName]??Bu[qd]},get header(){return this.MSA?.getHeader()??{}},get alignmentNames(){return this.MSA?.alignmentNames??[]},get noTree(){return!!this.tree.noTree},get noDomains(){return e.annotations.length===0},get unshareableData(){if(e.hostRestoresData)return[];let{data:t}=e,r=M3(e.columnTracks).filter(n=>n>xa).reduce((n,o)=>n+o,0);return[["alignment",t.msa,e.msaFilehandle],["tree",t.tree,e.treeFilehandle],["annotations",t.gff,e.gffFilehandle],["row metadata",t.treeMetadata,e.treeMetadataFilehandle]].flatMap(([n,o,i])=>!i&&o&&o.length>xa?[{what:n,bytes:o.length}]:[]).concat(r?[{what:"data tracks",bytes:r}]:[]).sort((n,o)=>o.bytes-n.bytes)},menuItems(){return[]},get rowData(){let t=e.data.treeMetadata;if(!t)return{};try{let r=JSON.parse(t);return typeof r=="object"&&r!==null?r:{}}catch(r){return console.error("failed to parse rowData",r),{}}},rowDataOf(t){return this.rowData[t]},get rowFields(){let t=new Set;for(let r of Object.values(this.rowData))for(let n of Object.keys(r??{}))t.add(n);return[...t].sort((r,n)=>r.localeCompare(n))},get MSA(){let t=e.data.msa;return t?Qu(t,e.currentAlignment,e.msaFormat):null},get numColumns(){return(this.MSA?.getWidth()??0)-this.blanks.length},get tree(){let t=e.data.tree;return t?Tu(Tee(t)):this.MSA?.getTree()??{noTree:!0,children:[],id:"empty",name:"empty"}},get rowNames(){return this.leaves.map(t=>t.data.name)},get rowNamesSet(){return new Map(this.leaves.map((t,r)=>[t.data.name,r]))},get resolvedClades(){return e.clades.length===0?C3:x3(e.clades,wy(this.tree,t=>t.children),this.rowNamesSet)},get cladeGutterWidth(){return MT({clades:this.resolvedClades,rowHeight:e.rowHeight,fontSize:this.fontSize})},get mouseOverRowName(){let{mouseRow:t}=e;return t===void 0?void 0:this.leaves[t]?.data.name},get hoveredInsertion(){let{mouseCol:t,mouseRow:r}=e;if(t!==void 0&&r!==void 0){let n=this.leaves[r]?.data.name;if(n){let o=this.insertionPositions.get(n)?.find(i=>i.pos===t);if(o)return{rowName:n,col:t,letters:o.letters}}}},get root(){return E3(this.tree,e.collapsed,e.showOnly)},get treeOverviewHeight(){return e.showTreeOverview?e.overviewHeight:0},get treeOverviewLayout(){if(!e.showTreeOverview)return;let t=E3(this.tree,e.collapsed),r=Ur(t).length;Sy(t,r,1);let n=Math.max(t.data.length||0,0),o=Iy(t)-n;return vy(t,-n,o?1/o:0),{root:t,numTips:r,maxDepthToLeaf:Ba(t),showBranchLen:e.showBranchLen&&o>0}},get treeOverviewClades(){let t=this.treeOverviewLayout;if(!t||e.clades.length===0)return C3;let r=new Map(Ur(t.root).map((n,o)=>[n.data.name,o]));return x3(e.clades,t.root,r)},get treeOverviewFocusRows(){let t=this.treeOverviewLayout;if(!t||!e.showOnly)return;let r=Fi(t.root,n=>n.data.id===e.showOnly);return r?w3(r):void 0},treeOverviewHit(t){let r=this.treeOverviewLayout;if(!r)return;let{root:n,numTips:o}=r,i=o/e.overviewHeight,s=(0,fe.clamp)(Math.floor(t*i),0,o-1),a=(0,fe.clamp)(Math.ceil((t+1)*i)-1,s,o-1),l=Im(n,s+.5,a+.5);for(;!l.children&&l.parent;)l=l.parent;return l===n?void 0:{id:l.data.id,rows:w3(l)}},get rowPanelsWidth(){return(0,fe.sum)(e.rowPanels.map(t=>p3(t,e.rowHeight)))},get rowPanelsHeaderHeight(){return e.rowPanels.length>0?Yd:0},get msaAreaWidth(){return e.width-e.treeAreaWidth-this.rowPanelsWidth-e.resizeHandleWidth},get treeAreaWidthMinusMargin(){return e.treeAreaWidth-e.marginLeft-this.cladeGutterWidth},get blanks(){let{hideGapsEffective:t,realAllowedGappyness:r}=e;if(!t)return[];let n=this.leaves.map(c=>this.MSA?.getRow(c.data.name)).filter(fe.notEmpty);if(n.length===0)return[];let o=n.reduce((c,u)=>Math.max(c,u.length),0),i=n.length,s=Math.ceil(r/100*i),a=new Uint32Array(o);for(let c=0;c<i;c++){let u=n[c],f=u.length;for(let m=0;m<o;m++)(m>=f||u.charCodeAt(m)-45>>>0<=1)&&a[m]++}let l=[];for(let c=0;c<o;c++)a[c]>=s&&l.push(c);return l},get insertionPositions(){let{blanks:t,rows:r}=this;if(t.length===0)return new Map;let n=new Map;for(let[o,i]of r){let s=lT(t,i);s.length>0&&n.set(o,s)}return n},get rows(){let t=this.MSA;return this.leaves.map(r=>[r.data.name,t?.getRow(r.data.name)]).filter(r=>!!r[1])},get numRows(){return this.leaves.length},seqPosIndex(t){let r=this.MSA;if(!r)return;let n=I3.get(r);n||(n=new Map,I3.set(r,n));let o=n.get(t);if(!o){let i=r.getRow(t);if(!i)return;o=o3(i),n.set(t,o)}return o},get rowMap(){let t=this.MSA;return new Map(t?.getNames().map(r=>[r,t.getRow(r)]).filter(([,r])=>!!r))},get columns(){let t=this.columns2d;return new Map(this.rows.map((r,n)=>[r[0],t[n]]))},get columns2d(){let{hideGapsEffective:t}=e;return this.rows.map(([,r])=>(t?rm(this.blanks,r):r).toUpperCase())},get fontSize(){return Math.min(Math.max(6,e.rowHeight-3),18)},get colStats(){return IT(this.columns2d)},get sequenceType(){let t=this.colStats.lettersPresent,r=new Set(["A","C","G","T","N"]),n=new Set(["A","C","G","U","N"]),o=t.size>0&&[...t].every(s=>r.has(s)),i=t.size>0&&[...t].every(s=>n.has(s));return o?"dna":i?"rna":"amino"},get colConsensus(){let{colStats:t}=this;return Array.from({length:t.numColumns},(r,n)=>{let o=t.total(n),i=0,s="";t.forEachResidue(n,(l,c)=>{c>i&&(i=c,s=Am(l))});let a=o?i/o:0;return{letter:s,color:a>.4?`hsl(240, 30%, ${100*Math.max(1-a/3,.3)}%)`:void 0}})},get colClustalX(){let{colStats:t}=this;return Array.from({length:t.numColumns},(r,n)=>dO(t,n))},get conservation(){let{colStats:t,alphabetMaxBits:r}=this;return Array.from({length:t.numColumns},(n,o)=>{let i=t.total(o),s=t.gapCount(o);return i>s?Math.max(0,1-t.entropy(o)/r)*(1-s/i):0})},get alphabetMaxBits(){return vT(this.sequenceType)},get propertyConservation(){return this.sequenceType==="amino"?JO(this.colStats):[]},get hierarchy(){let t=this.root;Sy(t,this.totalHeight,e.treeWidth);let r=this.rootToTipLength,n=r?e.treeWidth/r:0;return vy(t,-Math.max(t.data.length||0,0),n),va(t,o=>{o._children&&(o.collapsedTipXFar=(o.len??0)+DT(o)*n)}),t},get totalHeight(){return Ur(this.root).length*e.rowHeight},get leaves(){return Ur(this.hierarchy)},get rootToTipLength(){let t=this.root;return Iy(t)-Math.max(t.data.length||0,0)},get maxBranchLength(){return this.rootToTipLength?e.treeWidth:0},get pxPerBranchLength(){let t=this.rootToTipLength;return this.showBranchLenEffective&&t?e.treeWidth/t:0},get maxDepthToLeaf(){return Ba(this.hierarchy)},get allBranchesLength0(){return this.rootToTipLength===0},get showBranchLenEffective(){return this.allBranchesLength0?!1:e.showBranchLen}})).views(e=>({get totalWidth(){return e.numColumns*e.colWidth}})).views(e=>({get showMsaLetters(){return e.drawMsaLetters&&e.rowHeight>=$0&&e.colWidth>=MB&&e.colWidth>e.rowHeight/2},get showTreeText(){return e.drawLabels&&e.rowHeight>=$0}})).views(e=>{let t=new WeakMap;return{get columnTrackContent(){let{MSA:r,blanks:n,hideGapsEffective:o}=e,i=r?.getWidth()??0,s=(c,u,f)=>{if(!c.row)return u;let m=Array.from({length:i},()=>f),d=e.seqPosIndex(c.row);return u.forEach((p,h)=>{let y=d?.[h];y!==void 0&&(m[y]=p)}),m},a=c=>o?cT(n,c):c,l=(c,u)=>{let f=c.row?e.seqPosIndex(c.row)?.[u-1]:u-1;if(!(f===void 0||f<0||f>=i))return o?gc(n,f):f};return new Map(e.columnTracks.map(c=>{if(c.kind==="arc"){let f=(c.arcs??[]).map(m=>{let d=l(c,Math.min(m.start,m.end)),p=l(c,Math.max(m.start,m.end));return d!==void 0&&p!==void 0&&d<p?{start:d,end:p,color:m.color}:void 0}).filter(fe.notEmpty);return[c.id,{arcs:f}]}if(c.kind==="bar"){let f=c.max??1,m=a(s(c,c.values??[],0)).map(d=>Math.min(1,Math.max(0,d/f)));return[c.id,{values:m}]}let u=a(s(c,(c.data??"").split("")," "));return[c.id,{data:u.join("")}]}))},trackHeight(r,n=r,o){return e.trackHeights.get(n)??o??Mee[r]??e.rowHeight},columnTrackModel(r){let n=t.get(r);return n||(n=(0,rt.computed)(()=>{let o=m3.has(r.kind)?kee(r.id):void 0,i=this.columnTrackContent.get(r.id);return{model:{id:r.id,name:r.name,kind:r.kind,heightKey:o,height:this.trackHeight(r.kind,o,r.height),barColor:r.color,arcColor:r.color,customColorScheme:r.colors,data:i?.data,arcs:i?.arcs},ReactComponent:Yu}}),t.set(r,n)),n.get()},get columnTrackModels(){return e.columnTracks.map(r=>this.columnTrackModel(r))}}}).views(e=>({get labelWidthMap(){let{showTreeText:t,leaves:r}=e;return t?new Map(r.map(n=>{let{name:o}=n.data,i=e.rowDataOf(o)?.genome||o;return[o,Ia(i,V0)]})):new Map},get labelWidthScale(){return e.fontSize/V0},get labelsWidth(){let t=0;for(let r of this.labelWidthMap.values())r>t&&(t=r);return t*this.labelWidthScale},get secondaryStructureConsensus(){return e.MSA?.secondaryStructureConsensus},get seqConsensus(){return e.MSA?.seqConsensus},get secondaryStructureArcs(){let{blanks:t,hideGapsEffective:r}=e,n=this.secondaryStructureConsensus;if(n)return l3(r?rm(t,n):n).map(({start:o,end:i,pseudoknot:s})=>({start:o,end:i,color:s?_ee:Qee}))},get adapterTrackModels(){let{MSA:t,hideGapsEffective:r,blanks:n}=e,o=(t?.tracks??[]).filter(s=>!!s.data);if(o.length===0)return[];let{rowHeight:i}=e;return o.map(s=>({model:{...s,kind:"text",data:r?rm(n,s.data):s.data,height:i},ReactComponent:Yu}))},get basePairTrackModels(){let t=this.secondaryStructureArcs;return t?.length?[{model:{id:"base-pairs",name:"Base pairs",kind:"arc",heightKey:"arc",height:e.trackHeight("arc"),arcs:t},ReactComponent:Yu}]:[]},get computedTrackModels(){return[{id:"conservation",name:"Conservation",kind:"bar",barColor:"gray"},...e.sequenceType==="amino"?[{id:"property-conservation",name:"Property conservation",kind:"bar",barColor:"#6a51a3"}]:[],{id:"sequence-logo",name:"Sequence logo",kind:"logo"},{id:"position-ruler",name:"Position",kind:"ruler"}].map(t=>({model:{...t,heightKey:m3.has(t.kind)?t.kind:void 0,height:e.trackHeight(t.kind)},ReactComponent:Yu}))},get tracks(){return[...this.adapterTrackModels,...this.basePairTrackModels,...e.columnTrackModels,...e.numColumns>0?this.computedTrackModels:[]]},get turnedOnTracks(){return this.tracks.filter(t=>!y3(e.turnedOffTracks,t.model.id,t.model.defaultOff))},get showHorizontalScrollbar(){return B3(e.totalWidth,e.msaAreaWidth)},visibleColToRowLetter(t,r){return e.rowMap.get(t)?.[this.visibleColToGlobalCol(r)]},visibleColToSeqPos(t,r){return t3(e.seqPosIndex(t),this.visibleColToGlobalCol(r))},visibleColToSeqPosOneBased(t,r){let n=this.visibleColToSeqPos(t,r);return n!==void 0?n+1:void 0},globalColToVisibleCol(t){let{blanks:r,hideGapsEffective:n}=e;return n?ZO(r,t):t},visibleColToGlobalCol(t){let{blanks:r,hideGapsEffective:n}=e;return n?XO(r,t):t},seqPosToGlobalCol(t,r){let n=e.rowMap.get(t);return n===void 0?void 0:e.seqPosIndex(t)?.[r]??(r===0?0:n.length)},seqPosToVisibleCol(t,r){let n=this.seqPosToGlobalCol(t,r);return n===void 0?void 0:this.globalColToVisibleCol(n)},visibleSpan({row:t,start:r,end:n}){let{blanks:o}=e,i=Math.max(1,Math.floor(r)),s=Math.ceil(n),a=i-1,l=s-1;if(t!==void 0){let f=this.seqPosToGlobalCol(t,i-1),m=this.seqPosToGlobalCol(t,s-1);if(f===void 0||m===void 0)return;a=f,l=m}let c=this.globalColToVisibleCol(a)??gc(o,a),u=this.globalColToVisibleCol(l)??gc(o,l)-1;return c<=u?{startCol:c,endCol:u}:void 0},get residueMappingProblems(){let t=[];for(let r of e.residueMappings){let n={row:r.row,structureId:r.structure.id},o=e.seqPosIndex(r.row)?.length;if(o===void 0){t.push({...n,scope:"mapping",reason:"no such row in the alignment"});continue}if(r.rowLength!==void 0&&r.rowLength!==o){t.push({...n,scope:"mapping",reason:`computed against a ${r.rowLength}-residue row; this one has ${o}`});continue}let i=r.segments.find(s=>s.rowEnd>o||s.rowStart<1);if(i){t.push({...n,scope:"mapping",reason:`segment ${i.rowStart}-${i.rowEnd} does not fit a ${o}-residue row`});continue}for(let s of r.segments)v3(s)||t.push({...n,scope:"segment",reason:`segment ${s.rowStart}-${s.rowEnd} maps to ${s.structStart}-${s.structEnd}, which is a different length`})}return t},get usableResidueMappings(){let t=new Set(this.residueMappingProblems.filter(r=>r.scope==="mapping").map(r=>`${r.row}\0${r.structureId}`));return e.residueMappings.filter(r=>!t.has(`${r.row}\0${r.structure.id}`)).map(r=>({...r,segments:r.segments.filter(v3)}))},get mappedStructures(){return this.usableResidueMappings.map(t=>({row:t.row,structure:t.structure}))},structureResidue(t,r,n){let o=[];for(let i of this.usableResidueMappings){if(i.row!==t||n!==void 0&&i.structure.id!==n)continue;let s=i.segments.find(a=>r>=a.rowStart&&r<=a.rowEnd);if(s){let a=s.structStart+(r-s.rowStart);o.push({structure:i.structure,position:a,observed:!Uee(i.unobserved,a)})}}return o.length===1?o[0]:void 0},rowResidue(t,r,n){let o=[];for(let i of this.usableResidueMappings){if(i.structure.id!==t||n!==void 0&&i.structure.asymId!==n)continue;let s=i.segments.find(a=>r>=a.structStart&&r<=a.structEnd);s&&o.push({rowName:i.row,seqPos:s.rowStart+(r-s.structStart)})}return o.length===1?o[0]:void 0}})).views(e=>({get treeScaleBar(){return bO(e.pxPerBranchLength,e.treeAreaWidth-e.marginLeft*2)},get topBandHeight(){return Math.max(e.showHorizontalScrollbar?e.minimapHeight:0,e.rowPanelsHeaderHeight,e.treeOverviewHeight+(this.treeScaleBar?qn:0))},get msaAreaHeight(){return e.height-this.topBandHeight-e.headerHeight-this.totalTrackAreaHeight},get totalTrackAreaHeight(){return(0,fe.sum)(e.turnedOnTracks.map(t=>t.model.height))},get annotationTypes(){let t=new Map;for(let r of e.annotations)t.has(r.accession)||t.set(r.accession,r);return t},get filteredAnnotations(){return e.annotations.filter(t=>!e.turnedOffFeatures.get(t.accession))},get annotationsByRow(){return(0,fe.groupBy)(this.filteredAnnotations,t=>t.id)}})).views(e=>({get showVerticalScrollbar(){return B3(e.totalHeight,e.msaAreaHeight)}})).views(e=>({get dataInitialized(){return!!(e.data.msa||e.data.tree)&&!e.error},get blocksX(){return rE({viewportSize:e.msaAreaWidth,viewportPos:-e.scrollX,blockSize:e.blockSize,mapSize:e.totalWidth})},get blocksY(){return rE({viewportSize:e.msaAreaHeight,viewportPos:-e.scrollY,blockSize:e.blockSize,mapSize:e.totalHeight})}})).views(e=>({get blocks2d(){return e.blocksY.flatMap(t=>e.blocksX.map(r=>[r,t]))},get isLoading(){return e.loadingMSA||e.loadingTree},get maxScrollX(){return Math.min(-e.totalWidth+(e.msaAreaWidth-100),0)},get maxScrollY(){return Math.min(-e.totalHeight+e.msaAreaHeight,0)},get wheelZoomAxis(){return 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Mc,Z4,eG,tG,$E,rG,hre,yre,bre,Cre,nG=A(()=>{cf();Mc=15,Z4=852,eG=592,tG=0,$E=1,rG=2,hre=[3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0],yre=[16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78],bre=[1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0],Cre=[16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64]});function BG(e){return(e>>>24&255)+(e>>>8&65280)+((e&65280)<<8)+((e&255)<<24)}function Mre(){this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=ci(320),this.work=ci(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}function Rre(e){var t;return!e||!e.state?kr:(t=e.state,e.total_in=e.total_out=t.total=0,e.msg="",t.wrap&&(e.adler=t.wrap&1),t.mode=QG,t.last=0,t.havedict=0,t.dmax=32768,t.head=null,t.hold=0,t.bits=0,t.lencode=t.lendyn=ws(Bre),t.distcode=t.distdyn=ws(Tre),t.sane=1,t.back=-1,Is)}function kre(e){var t;return!e||!e.state?kr:(t=e.state,t.wsize=0,t.whave=0,t.wnext=0,Rre(e))}function Qre(e,t){var r,n;return!e||!e.state||(n=e.state,t<0?(r=0,t=-t):(r=(t>>4)+1,t<48&&(t&=15)),t&&(t<8||t>15))?kr:(n.window!==null&&n.wbits!==t&&(n.window=null),n.wrap=r,n.wbits=t,kre(e))}function _G(e,t){var r,n;return e?(n=new Mre,e.state=n,n.window=null,r=Qre(e,t),r!==Is&&(e.state=null),r):kr}function _re(e){if(TG){var t;for(qE=ws(512),zE=ws(32),t=0;t<144;)e.lens[t++]=8;for(;t<256;)e.lens[t++]=9;for(;t<280;)e.lens[t++]=7;for(;t<288;)e.lens[t++]=8;for(Ss(MG,e.lens,0,288,qE,0,e.work,{bits:9}),t=0;t<32;)e.lens[t++]=5;Ss(RG,e.lens,0,32,zE,0,e.work,{bits:5}),TG=!1}e.lencode=qE,e.lenbits=9,e.distcode=zE,e.distbits=5}function DG(e,t,r,n){var o,i=e.state;return i.window===null&&(i.wsize=1<<i.wbits,i.wnext=0,i.whave=0,i.window=po(i.wsize)),n>=i.wsize?(Fn(i.window,t,r-i.wsize,i.wsize,0),i.wnext=0,i.whave=i.wsize):(o=i.wsize-i.wnext,o>n&&(o=n),Fn(i.window,t,r-n,o,i.wnext),n-=o,n?(Fn(i.window,t,r-n,n,0),i.wnext=n,i.whave=i.wsize):(i.wnext+=o,i.wnext===i.wsize&&(i.wnext=0),i.whave<i.wsize&&(i.whave+=o))),0}function NG(e,t){var r,n,o,i,s,a,l,c,u,f,m,d,p,h,y=0,b,C,I,x,S,v,B,Q,_=po(4),M,N,G=[16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15];if(!e||!e.state||!e.output||!e.input&&e.avail_in!==0)return kr;r=e.state,r.mode===Ao&&(r.mode=VE),s=e.next_out,o=e.output,l=e.avail_out,i=e.next_in,n=e.input,a=e.avail_in,c=r.hold,u=r.bits,f=a,m=l,Q=Is;e:for(;;)switch(r.mode){case QG:if(r.wrap===0){r.mode=VE;break}for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(r.wrap&2&&c===35615){r.check=0,_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0),c=0,u=0,r.mode=sG;break}if(r.flags=0,r.head&&(r.head.done=!1),!(r.wrap&1)||(((c&255)<<8)+(c>>8))%31){e.msg="incorrect header check",r.mode=Fe;break}if((c&15)!==iG){e.msg="unknown compression method",r.mode=Fe;break}if(c>>>=4,u-=4,B=(c&15)+8,r.wbits===0)r.wbits=B;else if(B>r.wbits){e.msg="invalid window size",r.mode=Fe;break}r.dmax=1<<B,e.adler=r.check=1,r.mode=c&512?pG:Ao,c=0,u=0;break;case sG:for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(r.flags=c,(r.flags&255)!==iG){e.msg="unknown compression method",r.mode=Fe;break}if(r.flags&57344){e.msg="unknown header flags set",r.mode=Fe;break}r.head&&(r.head.text=c>>8&1),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0)),c=0,u=0,r.mode=aG;case aG:for(;u<32;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.head&&(r.head.time=c),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,_[2]=c>>>16&255,_[3]=c>>>24&255,r.check=Rr(r.check,_,4,0)),c=0,u=0,r.mode=cG;case cG:for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.head&&(r.head.xflags=c&255,r.head.os=c>>8),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0)),c=0,u=0,r.mode=lG;case lG:if(r.flags&1024){for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.length=c,r.head&&(r.head.extra_len=c),r.flags&512&&(_[0]=c&255,_[1]=c>>>8&255,r.check=Rr(r.check,_,2,0)),c=0,u=0}else r.head&&(r.head.extra=null);r.mode=uG;case uG:if(r.flags&1024&&(d=r.length,d>a&&(d=a),d&&(r.head&&(B=r.head.extra_len-r.length,r.head.extra||(r.head.extra=new Array(r.head.extra_len)),Fn(r.head.extra,n,i,d,B)),r.flags&512&&(r.check=Rr(r.check,n,d,i)),a-=d,i+=d,r.length-=d),r.length))break e;r.length=0,r.mode=fG;case fG:if(r.flags&2048){if(a===0)break e;d=0;do B=n[i+d++],r.head&&B&&r.length<65536&&(r.head.name+=String.fromCharCode(B));while(B&&d<a);if(r.flags&512&&(r.check=Rr(r.check,n,d,i)),a-=d,i+=d,B)break e}else r.head&&(r.head.name=null);r.length=0,r.mode=dG;case dG:if(r.flags&4096){if(a===0)break e;d=0;do B=n[i+d++],r.head&&B&&r.length<65536&&(r.head.comment+=String.fromCharCode(B));while(B&&d<a);if(r.flags&512&&(r.check=Rr(r.check,n,d,i)),a-=d,i+=d,B)break e}else r.head&&(r.head.comment=null);r.mode=mG;case mG:if(r.flags&512){for(;u<16;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(c!==(r.check&65535)){e.msg="header crc mismatch",r.mode=Fe;break}c=0,u=0}r.head&&(r.head.hcrc=r.flags>>9&1,r.head.done=!0),e.adler=r.check=0,r.mode=Ao;break;case pG:for(;u<32;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}e.adler=r.check=BG(c),c=0,u=0,r.mode=eg;case eg:if(r.havedict===0)return e.next_out=s,e.avail_out=l,e.next_in=i,e.avail_in=a,r.hold=c,r.bits=u,Sre;e.adler=r.check=1,r.mode=Ao;case Ao:if(t===Ere||t===KA)break e;case VE:if(r.last){c>>>=u&7,u-=u&7,r.mode=WE;break}for(;u<3;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}switch(r.last=c&1,c>>>=1,u-=1,c&3){case 0:r.mode=AG;break;case 1:if(_re(r),r.mode=XA,t===KA){c>>>=2,u-=2;break e}break;case 2:r.mode=hG;break;case 3:e.msg="invalid block type",r.mode=Fe}c>>>=2,u-=2;break;case AG:for(c>>>=u&7,u-=u&7;u<32;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if((c&65535)!==(c>>>16^65535)){e.msg="invalid stored block lengths",r.mode=Fe;break}if(r.length=c&65535,c=0,u=0,r.mode=jE,t===KA)break e;case jE:r.mode=gG;case gG:if(d=r.length,d){if(d>a&&(d=a),d>l&&(d=l),d===0)break e;Fn(o,n,i,d,s),a-=d,i+=d,l-=d,s+=d,r.length-=d;break}r.mode=Ao;break;case hG:for(;u<14;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(r.nlen=(c&31)+257,c>>>=5,u-=5,r.ndist=(c&31)+1,c>>>=5,u-=5,r.ncode=(c&15)+4,c>>>=4,u-=4,r.nlen>286||r.ndist>30){e.msg="too many length or distance symbols",r.mode=Fe;break}r.have=0,r.mode=yG;case yG:for(;r.have<r.ncode;){for(;u<3;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.lens[G[r.have++]]=c&7,c>>>=3,u-=3}for(;r.have<19;)r.lens[G[r.have++]]=0;if(r.lencode=r.lendyn,r.lenbits=7,M={bits:r.lenbits},Q=Ss(xre,r.lens,0,19,r.lencode,0,r.work,M),r.lenbits=M.bits,Q){e.msg="invalid code lengths set",r.mode=Fe;break}r.have=0,r.mode=bG;case bG:for(;r.have<r.nlen+r.ndist;){for(;y=r.lencode[c&(1<<r.lenbits)-1],b=y>>>24,C=y>>>16&255,I=y&65535,!(b<=u);){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(I<16)c>>>=b,u-=b,r.lens[r.have++]=I;else{if(I===16){for(N=b+2;u<N;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(c>>>=b,u-=b,r.have===0){e.msg="invalid bit length repeat",r.mode=Fe;break}B=r.lens[r.have-1],d=3+(c&3),c>>>=2,u-=2}else if(I===17){for(N=b+3;u<N;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}c>>>=b,u-=b,B=0,d=3+(c&7),c>>>=3,u-=3}else{for(N=b+7;u<N;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}c>>>=b,u-=b,B=0,d=11+(c&127),c>>>=7,u-=7}if(r.have+d>r.nlen+r.ndist){e.msg="invalid bit length repeat",r.mode=Fe;break}for(;d--;)r.lens[r.have++]=B}}if(r.mode===Fe)break;if(r.lens[256]===0){e.msg="invalid code -- missing end-of-block",r.mode=Fe;break}if(r.lenbits=9,M={bits:r.lenbits},Q=Ss(MG,r.lens,0,r.nlen,r.lencode,0,r.work,M),r.lenbits=M.bits,Q){e.msg="invalid literal/lengths set",r.mode=Fe;break}if(r.distbits=6,r.distcode=r.distdyn,M={bits:r.distbits},Q=Ss(RG,r.lens,r.nlen,r.ndist,r.distcode,0,r.work,M),r.distbits=M.bits,Q){e.msg="invalid distances set",r.mode=Fe;break}if(r.mode=XA,t===KA)break e;case XA:r.mode=ZA;case ZA:if(a>=6&&l>=258){e.next_out=s,e.avail_out=l,e.next_in=i,e.avail_in=a,r.hold=c,r.bits=u,UE(e,m),s=e.next_out,o=e.output,l=e.avail_out,i=e.next_in,n=e.input,a=e.avail_in,c=r.hold,u=r.bits,r.mode===Ao&&(r.back=-1);break}for(r.back=0;y=r.lencode[c&(1<<r.lenbits)-1],b=y>>>24,C=y>>>16&255,I=y&65535,!(b<=u);){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if(C&&(C&240)===0){for(x=b,S=C,v=I;y=r.lencode[v+((c&(1<<x+S)-1)>>x)],b=y>>>24,C=y>>>16&255,I=y&65535,!(x+b<=u);){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}c>>>=x,u-=x,r.back+=x}if(c>>>=b,u-=b,r.back+=b,r.length=I,C===0){r.mode=SG;break}if(C&32){r.back=-1,r.mode=Ao;break}if(C&64){e.msg="invalid literal/length code",r.mode=Fe;break}r.extra=C&15,r.mode=CG;case CG:if(r.extra){for(N=r.extra;u<N;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.length+=c&(1<<r.extra)-1,c>>>=r.extra,u-=r.extra,r.back+=r.extra}r.was=r.length,r.mode=xG;case xG:for(;y=r.distcode[c&(1<<r.distbits)-1],b=y>>>24,C=y>>>16&255,I=y&65535,!(b<=u);){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}if((C&240)===0){for(x=b,S=C,v=I;y=r.distcode[v+((c&(1<<x+S)-1)>>x)],b=y>>>24,C=y>>>16&255,I=y&65535,!(x+b<=u);){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}c>>>=x,u-=x,r.back+=x}if(c>>>=b,u-=b,r.back+=b,C&64){e.msg="invalid distance code",r.mode=Fe;break}r.offset=I,r.extra=C&15,r.mode=EG;case EG:if(r.extra){for(N=r.extra;u<N;){if(a===0)break e;a--,c+=n[i++]<<u,u+=8}r.offset+=c&(1<<r.extra)-1,c>>>=r.extra,u-=r.extra,r.back+=r.extra}if(r.offset>r.dmax){e.msg="invalid distance too far back",r.mode=Fe;break}r.mode=wG;case wG:if(l===0)break e;if(d=m-l,r.offset>d){if(d=r.offset-d,d>r.whave&&r.sane){e.msg="invalid distance too far back",r.mode=Fe;break}d>r.wnext?(d-=r.wnext,p=r.wsize-d):p=r.wnext-d,d>r.length&&(d=r.length),h=r.window}else h=o,p=s-r.offset,d=r.length;d>l&&(d=l),l-=d,r.length-=d;do o[s++]=h[p++];while(--d);r.length===0&&(r.mode=ZA);break;case SG:if(l===0)break 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Oe=d[R-1]-Sc,Xt=ys;h[R-1]-GA>Oe&&(Oe=h[R-1]-GA,Xt=Xu),p[R-1]-Sc>Oe&&(Oe=p[R-1]-Sc,Xt=Ic),h[R]=Oe,c[E+R]=Xt}for(let[R,L]of[[ys,d],[Ic,p],[Xu,h]])L[i]>y&&(y=L[i],b=N,C=i,I=R);if(N===o)for(let R=0;R<i;R++)for(let[L,U]of[[ys,d],[Ic,p],[Xu,h]])U[R]>y&&(y=U[R],b=o,C=R,I=L);[u,d]=[d,u],[f,p]=[p,f],[m,h]=[h,m]}let x=Array.from({length:o}).fill("-"),S=Array.from({length:o+1}).fill("");S[o]=t.slice(C);let v=b,B=C,Q=I,_=[],M=N=>{_.length&&(S[N]=_.reverse().join("")+S[N],_=[])};for(;v>0&&B>0;){let N=v*s+B;Q===ys?(M(v),x[v-1]=t[B-1],Q=a[N],v--,B--):Q===Ic?(M(v),Q=l[N],v--):(_.push(t[B-1]),Q=c[N],B--)}return M(v),S[0]=t.slice(0,B)+S[0],{matched:x,inserts:S}}function Bte(e,t){let r=e.sequence.length,n=new Array(r+1).fill(0);for(let{alignment:i}of t)for(let s=0;s<=r;s++)n[s]=Math.max(n[s],i.inserts[s].length);let o=(i,s)=>{let a=[];for(let l=0;l<=r;l++)a.push(s[l].padEnd(n[l],"-")),l<r&&a.push(i[l]);return a.join("")};return[{name:e.name,sequence:o(e.sequence.split(""),Array.from({length:r+1}).fill(""))},...t.map(({name:i,alignment:s})=>({name:i,sequence:o(s.matched,s.inserts)}))]}var vE=8;async function c4({query:e,targets:t,onProgress:r,signal:n}){let o=[];for(let i=0;i<t.length;i+=vE){r?.(`Aligning ${Math.min(i+vE,t.length)} of ${t.length} sequences in the browser...`),await bc(0,n);for(let s of t.slice(i,i+vE))o.push({name:s.name,alignment:vte(e.sequence,s.sequence)})}return Bte(e,o).map(i=>`>${i.name}
83
84
  ${i.sequence}`).join(`
84
- `)}function e4(e){let t=[];for(let r of e.split(">")){let[n,...o]=r.split(`
85
- `),i=n?.trim().split(/\s+/)[0];i&&t.push({name:i,sequence:o.join("").replaceAll(/[\s*-]/g,"")})}return t}wc();var Ate={clustalo:{params:{},msaResult:"aln-clustal_num",treeResult:"phylotree"},muscle:{params:{format:"clw",tree:"tree1"},msaResult:"fa",treeResult:"phylotree"},kalign:{params:{stype:"protein"},msaResult:"fa",treeResult:"phylotree"},mafft:{params:{stype:"protein"},msaResult:"fa",treeResult:"phylotree"}};async function GA({algorithm:e,sequence:t,onProgress:r,signal:n}){if(e==="browser"){let[l,...c]=e4(t);if(!l)throw new Error("Nothing to align");return{msa:await Z3({query:l,targets:c,onProgress:r,signal:n}),tree:""}}let o=Ate[e];r(`Launching ${e} MSA...`);let i=await xc({tool:e,params:{...o.params,sequence:t},signal:n});await Ec({tool:e,jobId:i,signal:n,onCountdown:l=>{r(`Re-checking MSA status in... ${l}`)}});let[s,a]=await Promise.all([gs({tool:e,jobId:i,type:o.msaResult,signal:n}),gs({tool:e,jobId:i,type:o.treeResult,signal:n})]);return{msa:s,tree:a}}yE();function gte(e,t){let r={},n=e.taxid?t.get(e.taxid):void 0;return n?.sciname&&(r["Scientific name"]=n.sciname),n?.commonName&&(r["Common name"]=n.commonName),e.accession&&(r.Accession=e.accession),e.id&&(r.ID=e.id),e.title&&(r.Description=e.title),r}function hte(e,t){let r=e.map(i=>P3(i,t)),n=new Map;for(let i of r)n.set(i,(n.get(i)??0)+1);let o=new Set;return r.map((i,s)=>{let a=n.get(i)>1?`${i}_${e[s].range??s+1}`:i;for(;o.has(a);)a=`${a}_${s+1}`;return o.add(a),a})}function t4({hits:e,query:t,queryRow:r,taxonomyInfo:n,querySeqName:o="QUERY"}){let i={},s=hte(e,n),a=e.map((l,c)=>{let u=s[c];return i[u]=gte(l,n),`>${u}
85
+ `)}function l4(e){let t=[];for(let r of e.split(">")){let[n,...o]=r.split(`
86
+ `),i=n?.trim().split(/\s+/)[0];i&&t.push({name:i,sequence:o.join("").replaceAll(/[\s*-]/g,"")})}return t}wc();var Tte={clustalo:{params:{},msaResult:"aln-clustal_num",treeResult:"phylotree"},muscle:{params:{format:"clw",tree:"tree1"},msaResult:"fa",treeResult:"phylotree"},kalign:{params:{stype:"protein"},msaResult:"fa",treeResult:"phylotree"},mafft:{params:{stype:"protein"},msaResult:"fa",treeResult:"phylotree"}};async function HA({algorithm:e,sequence:t,onProgress:r,signal:n}){if(e==="browser"){let[l,...c]=l4(t);if(!l)throw new Error("Nothing to align");return{msa:await c4({query:l,targets:c,onProgress:r,signal:n}),tree:""}}let o=Tte[e];r(`Launching ${e} MSA...`);let i=await xc({tool:e,params:{...o.params,sequence:t},signal:n});await Ec({tool:e,jobId:i,signal:n,onCountdown:l=>{r(`Re-checking MSA status in... ${l}`)}});let[s,a]=await Promise.all([gs({tool:e,jobId:i,type:o.msaResult,signal:n}),gs({tool:e,jobId:i,type:o.treeResult,signal:n})]);return{msa:s,tree:a}}CE();function Mte(e,t){let r={},n=e.taxid?t.get(e.taxid):void 0;return n?.sciname&&(r["Scientific name"]=n.sciname),n?.commonName&&(r["Common name"]=n.commonName),e.accession&&(r.Accession=e.accession),e.id&&(r.ID=e.id),e.title&&(r.Description=e.title),r}function Rte(e,t){let r=e.map(i=>q3(i,t)),n=new Map;for(let i of r)n.set(i,(n.get(i)??0)+1);let o=new Set;return r.map((i,s)=>{let a=n.get(i)>1?`${i}_${e[s].range??s+1}`:i;for(;o.has(a);)a=`${a}_${s+1}`;return o.add(a),a})}function u4({hits:e,query:t,queryRow:r,taxonomyInfo:n,querySeqName:o="QUERY"}){let i={},s=Rte(e,n),a=e.map((l,c)=>{let u=s[c];return i[u]=Mte(l,n),`>${u}
86
87
  ${l.sequence}`});return{msa:[`>${o}
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88
  ${r??t}`,...a].join(`
88
- `),treeMetadata:i}}mo();var yte="jbrowse-plugin-msaview",bte="colin.diesh@gmail.com",n4="https://eutils.ncbi.nlm.nih.gov/entrez/eutils";function o4(e){return new URLSearchParams({...e,tool:yte,email:bte})}function bs(e,t){return`${n4}/${e}.fcgi?${o4(t).toString()}`}function vc(e){return bs("efetch",e)}function i4(e){return[`${n4}/efetch.fcgi`,{method:"POST",body:o4(e)}]}var Cte=350,r4=0;async function s4(e){let t=Date.now(),r=Math.max(t,r4);r4=r+Cte,r>t&&await bc(r-t,e??void 0)}async function Cs(e,t){return await s4(t?.signal),yc(e,t)}async function Bc(e,t){return await s4(t?.signal),ur(e,t)}var xte={amp:"&",apos:"'",gt:">",lt:"<",quot:'"'};function Zu(e){return e.replaceAll(/&(#x[\da-f]+|#\d+|[a-z]+);/gi,(t,r)=>r.startsWith("#x")||r.startsWith("#X")?String.fromCodePoint(Number.parseInt(r.slice(2),16)):r.startsWith("#")?String.fromCodePoint(Number(r.slice(1))):xte[r]??t)}var Ete="jbrowse-msaview-taxonomy-cache",ef="common-names",wte=2,a4=ni(Ete,wte,e=>{e.objectStoreNames.contains(ef)&&e.deleteObjectStore(ef),e.createObjectStore(ef,{keyPath:"taxid"})});function Ste(e){return oi("taxonomy cache read",async()=>{let r=(await a4()).transaction(ef,"readonly"),n=await Promise.all(e.map(o=>r.store.get(o)));return await r.done,n},[])}function Ite(e){return oi("taxonomy cache write",async()=>{let r=(await a4()).transaction(ef,"readwrite");for(let n of e)await r.store.put(n);await r.done},void 0)}async function ii(e){let t=[...new Set(e)],r=new Map,n=[],o=await Ste(t);for(let a=0;a<t.length;a++){let l=t[a],c=o[a];c?r.set(l,{sciname:c.sciname,commonName:c.commonName}):n.push(l)}if(n.length===0)return r;let i=100,s=[];for(let a=0;a<n.length;a+=i){let l=n.slice(a,a+i),c=l.join(",");try{let u=await Cs(vc({db:"taxonomy",id:c,retmode:"xml"})),f=new Map,m=/<Taxon>\s*<TaxId>(\d+)<\/TaxId>/g,d;for(;(d=m.exec(u))!==null;){let p=Number(d[1]),h=d.index,y=1,b=h+d[0].length;for(;y>0&&b<u.length;){let v=u.indexOf("<Taxon>",b),B=u.indexOf("</Taxon>",b);if(B===-1)break;v!==-1&&v<B?(y++,b=v+7):(y--,b=B+8)}let C=u.slice(h,b),I=f.get(p),x=C.includes("<LineageEx>"),S=I?.includes("<LineageEx>");(!I||x&&!S)&&f.set(p,C)}for(let p of l){let h=f.get(p);if(h){let y=/<GenbankCommonName>(.*?)<\/GenbankCommonName>/.exec(h),b=/<CommonName>(.*?)<\/CommonName>/.exec(h),C=/<ScientificName>(.*?)<\/ScientificName>/.exec(h),I=y?.[1]??b?.[1],x=I&&Zu(I),S=Zu(C?.[1]??"");r.set(p,{sciname:S,commonName:x}),s.push({taxid:p,sciname:S,commonName:x})}}}catch(u){console.error("Failed to fetch taxonomy data:",u)}}return s.length>0&&await Ite(s),r}mo();mo();var l4="https://api.ncbi.nlm.nih.gov/datasets/v2",si=100;function tf(e){return e.trim().replace(/^\w+:/,"").replace(/\.\d+$/,"")}async function u4(e,t){let r=new Set;for(let n of e){let o=n.trim();if(/^\d+$/.test(o))return{geneId:o,matched:o};let i=tf(o);if(!i||r.has(i))continue;r.add(i);let a=(await Bc(bs("esearch",{db:"gene",term:`${i}[Gene Name] AND ${t}[taxid]`,retmode:"json",retmax:"1"}))).esearchresult?.idlist?.[0];if(a)return{geneId:a,matched:i}}}async function vte(e,{taxa:t,exclude:r,limit:n=si}={}){let o=await ur(`${l4}/gene/id/${e}/orthologs?returned_content=COMPLETE`),i=new Map;for(let{gene:s}of o.reports??[]){let a=Number(s?.tax_id);if(s?.gene_id&&a!==r&&(t?.has(a)??!0)&&!i.has(a)&&i.set(a,{taxId:a,geneId:s.gene_id,scientificName:s.taxname??String(a),commonName:s.common_name}),i.size>=n)break}return[...i.values()]}var c4=150;async function f4(e){let t=new Map;for(let r=0;r<e.length;r+=c4){let n=e.slice(r,r+c4),o=await ur(`${l4}/gene/id/${n.join(",")}/product_report?page_size=${n.length}`);for(let{product:i}of o.reports??[]){let s=(i?.transcripts??[]).map(l=>({acc:l.protein?.accession_version,len:l.protein?.length??0,mane:/select/i.test(l.select_category??"")})).filter(l=>!!l.acc),a=s.find(l=>l.mane)??[...s].sort((l,c)=>c.len-l.len).at(0);i?.gene_id&&a&&t.set(i.gene_id,a.acc)}}return t}function d4(e){let t=new Map,r,n=[];for(let o of e.split(`
89
- `))o.startsWith(">")?(r&&t.set(r,n.join("")),r=o.slice(1).split(/\s+/)[0],n=[]):n.push(o.trim());return r&&t.set(r,n.join("")),t}function Bte(e){return e.replace(/[^A-Za-z0-9]+/g,"_").replace(/^_+|_+$/g,"")}function xs(e){let t=new Set;return e.map(r=>{let n=Bte(r)||"row",o=n,i=1;for(;t.has(o);)i+=1,o=`${n}_${i}`;return t.add(o),o})}async function m4(e){let t=(await f4([e])).get(e);if(!t)return;let r=d4(await Cs(vc({db:"protein",id:t,rettype:"fasta",retmode:"text"}))).get(t);return r?{accession:t,sequence:r}:void 0}async function p4({geneId:e,taxa:t,exclude:r,limit:n,onProgress:o}){o("Finding orthologs across species...");let i=await vte(e,{taxa:t,exclude:r,limit:n});if(i.length<2)throw new Error(`Only ${i.length} ortholog(s) found for this gene \u2014 not enough to align`);o("Selecting a representative protein per species...");let s=await f4(i.map(m=>m.geneId)),a=i.filter(m=>s.has(m.geneId));if(a.length<2)throw new Error("Could not resolve representative proteins for the orthologs");o(`Fetching ${a.length} protein sequences...`);let l=a.map(m=>s.get(m.geneId)),c=d4(await Cs(...i4({db:"protein",id:l.join(","),rettype:"fasta",retmode:"text"}))),u=xs(a.map(m=>m.commonName??m.scientificName)),f=a.map((m,d)=>{let p=s.get(m.geneId);return{taxId:m.taxId,label:u[d],scientificName:m.scientificName,commonName:m.commonName,geneId:m.geneId,protein:p,sequence:c.get(p)??""}}).filter(m=>m.sequence);if(f.length<2)throw new Error("Could not fetch protein sequences for the orthologs");return f}var HA="https://rest.uniprot.org";var Tte="keyword:KW-1185",Mte=/^(?:[OPQ][0-9][A-Z0-9]{3}[0-9]|[A-NR-Z][0-9](?:[A-Z][A-Z0-9]{2}[0-9]){1,2})(?:-\d+)?$/,BE="accession,id,reviewed,organism_name,organism_id,protein_name,sequence";function A4(e){let{primaryAccession:t,uniProtkbId:r,organism:n,sequence:o}=e;if(!(!t||!n?.taxonId||!o?.value))return{accession:t,id:r??t,reviewed:/\breviewed\b/i.test(e.entryType??""),taxId:n.taxonId,scientificName:n.scientificName??String(n.taxonId),commonName:n.commonName,title:e.proteinDescription?.recommendedName?.fullName?.value??e.proteinDescription?.submissionNames?.[0]?.fullName?.value,sequence:o.value}}function g4(e){return(e.results??[]).flatMap(t=>{let r=A4(t);return r?[r]:[]})}function TE(e,t){return Number(t.reviewed)-Number(e.reviewed)||t.sequence.length-e.sequence.length}async function ME(e,t,r){for(let n of e){let o=tf(n);if(!o)continue;if(Mte.test(o)){let l=await ur(`${HA}/uniprotkb/${o}?fields=${BE}`,{signal:r}),c=A4(l);if(c)return c;continue}let i=`gene_exact:"${o.replaceAll('"',"")}" AND organism_id:${t}`,s=await ur(`${HA}/uniprotkb/search?query=${encodeURIComponent(i)}&fields=${BE}&size=25`,{signal:r}),[a]=g4(s).sort(TE);if(a)return a}}async function Rte(e,t,r){let n=`(uniprot_id:${e}) AND (identity:${t/100})`,i=(await ur(`${HA}/uniref/search?query=${encodeURIComponent(n)}&fields=id,count&size=1`,{signal:r})).results?.[0];return i?.id?{id:i.id,memberCount:i.memberCount}:void 0}var kte=500,Qte=5e3;function _te(e){let t=e.headers.get("link")??"";return/<([^>]+)>;\s*rel="next"/.exec(t)?.[1]}async function Dte({clusterId:e,identity:t,referenceProteomesOnly:r=!0,taxa:n,exclude:o,limit:i=si,onProgress:s,signal:a}){let l=[`uniref_cluster_${t}:${e}`,...r?[Tte]:[]].join(" AND "),c=`${HA}/uniprotkb/search?query=${encodeURIComponent(l)}&fields=${BE}&size=${kte}&format=json`,u=new Map,f=0,m;for(;c&&f<Qte;){let d=await LA(c,{signal:a});m??=Number(d.headers.get("x-total-results"))||void 0;let p=g4(await d.json());f+=p.length;for(let h of p){if(h.taxId===o||n&&!n.has(h.taxId))continue;let y=u.get(h.taxId);(!y||TE(h,y)<0)&&u.set(h.taxId,h)}if(s?.(`Read ${f}${m?` of ${m}`:""} cluster members, ${u.size} species...`),n&&[...n].every(h=>u.has(h)||h===o))break;c=p.length?_te(d):void 0}return{total:m,rows:[...u.values()].sort(TE).slice(0,i)}}async function h4({candidates:e,taxId:t,identity:r=50,referenceProteomesOnly:n=!0,taxa:o,exclude:i,limit:s=si,onProgress:a,signal:l}){a("Resolving the query at UniProt...");let c=await ME(e,t,l);if(!c)throw new Error(`UniProt has no entry for ${e.join(", ")} in taxon ${t}. Try the BLAST tab, which needs no gene identifier.`);a(`Finding the UniRef${r} cluster of ${c.id}...`);let u=await Rte(c.accession,r,l);if(!u)throw new Error(`${c.accession} is in no UniRef${r} cluster`);let{total:f,rows:m}=await Dte({clusterId:u.id,identity:r,referenceProteomesOnly:n,taxa:o,exclude:i,limit:s,onProgress:a,signal:l});if(m.length<1)throw new Error(`${u.id} has no other ${n?"reference-proteome ":""}member to align ${c.id} against`);let d=xs(m.map(p=>p.commonName??p.scientificName));return{query:c,clusterId:u.id,total:f,rows:m.map((p,h)=>({taxId:p.taxId,label:d[h],scientificName:p.scientificName,commonName:p.commonName,geneId:p.id,protein:p.accession,sequence:p.sequence}))}}function UA(e){return e.rowMap.has(e.querySeqName)}function RE(e){return e?typeof e.toJSON=="function"?e.toJSON():e:{}}function y4(e){return typeof e=="string"?e:void 0}function $A(e){let t=RE(e);return y4(t.name)??y4(t.id)}function kE(e,t){let{querySeqName:r}=e;if(t<0)return;let n=e.seqPosToVisibleCol(r,t);return n!==void 0&&e.visibleColToSeqPos(r,n)===t?n:void 0}function VA(e,t){return kE(e,t-e.querySeqOffset)}function Es(e){return!!e&&typeof e=="object"&&"hoverPosition"in e&&!!e.hoverPosition}function b4(e){return/AF-([A-Z0-9]+)-F\d+/.exec(e)?.[1]}function jA(e){return typeof e=="string"?e:void 0}async function Nte(e,t){let r=e.blastParams;if(r.proteinSequence)return{sequence:ri(r.proteinSequence),name:e.querySeqName};if(r.accession){t.onProgress(`Fetching ${r.accession} from UniProt...`);let n=await ME([r.accession],0,t.signal);if(!n)throw new Error(`UniProt has no entry ${r.accession}`);let o=`${n.id}_query`;return t.act(()=>{e.setQuerySeqName(o)}),{sequence:n.sequence,name:o}}throw new Error("No query: a search needs a proteinSequence, a UniProt accession, or a connectedTranscript to translate")}async function C4({self:e,scope:t}){let r=e.blastParams,{selectedTranscript:n,maxHits:o,searchProgram:i="blastp"}=r,{sequence:s,name:a}=await Nte(e,t),{onProgress:l,onRid:c,signal:u}=t,{hits:f,queryRow:m,rid:d}=await Y3[i]({query:s,database:r.blastDatabase,maxHits:o,onProgress:l,onRid:c,signal:u});if(f.length===0)throw new Error("No hits found");l("Fetching species taxonomy info...");let p=await ii(f.map(S=>S.taxid).filter(S=>S!==void 0)),{msa:h,treeMetadata:y}=t4({hits:f,query:s,queryRow:m,taxonomyInfo:p,querySeqName:a}),{msa:b,tree:C}=m?{msa:h,tree:""}:await GA({algorithm:r.msaAlgorithm??"browser",sequence:h,onProgress:l,signal:u}),I=RE(n),x=JSON.stringify(y);return await L3({proteinSequence:s,blastDatabase:r.blastDatabase,msaAlgorithm:m?void 0:r.msaAlgorithm??"browser",searchProgram:r.searchProgram,maxHits:o,msa:b,tree:C,treeMetadata:x,rid:d??"",geneId:jA(I.parentId),transcriptId:jA(I.uniqueId),transcriptName:$A(n),geneName:jA(I.gene_name)??jA(I.parentId)}),{msa:b,tree:C,treeMetadata:x}}mo();var w4="https://pantherdb.org/services/oai/pantherdb",Lte="https://rest.uniprot.org/uniprotkb";function Fte(e){return(e.search?.output?.genomes?.genome??[]).flatMap(r=>r.short_name&&r.taxon_id?[{code:r.short_name,taxId:r.taxon_id,name:r.name??r.short_name,longName:r.long_name??r.short_name}]:[])}function x4(e){let[t,...r]=(e??"").split("|"),n=r.find(i=>i.startsWith("UniProtKB="))?.slice(10),o=r.find(i=>!i.startsWith("UniProtKB="))??n;return t&&n&&o?{code:t,accession:n,geneRef:o}:void 0}function Pte(e){let t=e.search?.mapping,r=t?.mapped,n=Array.isArray(r)?r:r?[r]:[],o=[],i;for(let s of n){i??=x4(s.gene);let a=x4(s.target_gene);a&&(s.ortholog==="LDO"||s.ortholog==="O")&&o.push({...a,symbol:s.target_gene_symbol===void 0?void 0:String(s.target_gene_symbol),type:s.ortholog})}return{unmapped:!!t?.unmapped_ids,query:i,hits:o}}function Ote(e){let t=new Map;for(let r of e){let n=t.get(r.code);(!n||n.type==="O"&&r.type==="LDO")&&t.set(r.code,r)}return[...t.values()]}function Gte(e){let t=new Map;for(let r of e.results??[])r.primaryAccession&&r.sequence?.value&&t.set(r.primaryAccession,r.sequence.value);return t}var QE;function Hte(){return QE??=ur(`${w4}/supportedgenomes`).then(Fte).catch(e=>{throw QE=void 0,e}),QE}var E4=100;async function Ute(e){let t=new Map;for(let r=0;r<e.length;r+=E4){let n=e.slice(r,r+E4),o=await ur(`${Lte}/accessions?accessions=${n.join(",")}&fields=accession,sequence&format=json`);for(let[i,s]of Gte(o))t.set(i,s)}return t}async function $te(e,t,r){let n;for(let o of e){let i=tf(o);if(!i)continue;let s=new URLSearchParams({geneInputList:i,organism:String(t),orthologType:"all"});r&&s.set("targetOrganism",r.map(l=>l.taxId).join(","));let a=Pte(await ur(`${w4}/ortholog/matchortho?${s.toString()}`));if(!a.unmapped&&(n??=i,a.query))return{...a,matched:i}}return n===void 0?void 0:{matched:n,hits:[],query:void 0}}async function S4({candidates:e,taxId:t,taxa:r,exclude:n,limit:o=si,onProgress:i}){let s=await Hte(),a=new Map(s.map(x=>[x.taxId,x])),l=new Map(s.map(x=>[x.code,x])),c=a.get(t);if(!c)throw new Error(`PANTHER has no reference proteome for taxon ${t}. NCBI orthologs cover vertebrates and insects; try that source.`);let u=r?[...r].flatMap(x=>{let S=a.get(x);return S&&x!==n?[S]:[]}):void 0;i("Matching orthologs at PANTHER...");let f=await $te(e,t,u);if(!f)throw new Error(`PANTHER has no entry for ${e.join(", ")} in ${c.longName}. Try the NCBI BLAST tab, which needs no gene identifier.`);let m=new Map(u?.map((x,S)=>[x.taxId,S])),d=Ote(f.hits).map(x=>({hit:x,genome:l.get(x.code)})).filter(x=>!!x.genome&&x.genome.taxId!==n&&(u?m.has(x.genome.taxId):!0)).sort((x,S)=>u?m.get(x.genome.taxId)-m.get(S.genome.taxId):0).slice(0,o);if(d.length<2)throw new Error(`Only ${d.length} PANTHER ortholog(s) found for ${f.matched} \u2014 not enough to align`);i(`Fetching ${d.length} protein sequences from UniProt...`);let[p,h]=await Promise.all([Vte(d.map(x=>x.genome.taxId)),Ute([...f.query?[f.query.accession]:[],...d.map(x=>x.hit.accession)])]),y=d.map(({hit:x,genome:S})=>{let v=p.get(S.taxId);return{hit:x,genome:S,name:v?v.commonName??v.sciname:S.name,scientificName:v?.sciname||S.longName,commonName:v?.commonName}}),b=xs(y.map(x=>x.name)),C=y.map(({hit:x,genome:S,scientificName:v,commonName:B},Q)=>({taxId:S.taxId,label:b[Q],scientificName:v,commonName:B,geneId:x.geneRef,protein:x.accession,sequence:h.get(x.accession)??""})).filter(x=>x.sequence);if(C.length<2)throw new Error("Could not fetch protein sequences for the orthologs");let I=f.query&&h.get(f.query.accession);return{matched:f.matched,query:f.query&&I?{...f.query,sequence:I}:void 0,rows:C}}async function Vte(e){try{return await ii(e)}catch(t){return console.warn("[msaview-orthologs] taxonomy name lookup failed:",t),new Map}}async function I4({self:e,scope:t}){let{taxId:r,taxa:n,maxSpecies:o,geneCandidates:i,msaAlgorithm:s,proteinSequence:a,source:l="ncbi",identity:c,referenceProteomesOnly:u}=e.orthologParams,{onProgress:f,act:m,signal:d}=t,p={taxId:r,geneCandidates:i,taxa:n?new Set(n):void 0,exclude:r,limit:o,onProgress:f},{geneId:h,representative:y,rows:b}=l==="panther"?await zte(p):l==="uniref"?await qte({...p,identity:c,referenceProteomesOnly:u,signal:d}):await jte(p),C=a?ri(a):y?.sequence;if(!C)throw new Error(`No query protein: none was supplied and ${Wte[l]} returned no representative protein for gene ${h}.`);let I=await Yte(r,b);m(()=>{e.setQuerySeqName(I)});let x={[I]:Kte(e,h,C,y)};for(let v of b)x[v.label]=Xte(v);return{...await GA({algorithm:s,sequence:[`>${I}
89
+ `),treeMetadata:i}}mo();var kte="jbrowse-plugin-msaview",Qte="colin.diesh@gmail.com",d4="https://eutils.ncbi.nlm.nih.gov/entrez/eutils";function m4(e){return new URLSearchParams({...e,tool:kte,email:Qte})}function bs(e,t){return`${d4}/${e}.fcgi?${m4(t).toString()}`}function vc(e){return bs("efetch",e)}function p4(e){return[`${d4}/efetch.fcgi`,{method:"POST",body:m4(e)}]}var _te=350,f4=0;async function A4(e){let t=Date.now(),r=Math.max(t,f4);f4=r+_te,r>t&&await bc(r-t,e??void 0)}async function Cs(e,t){return await A4(t?.signal),yc(e,t)}async function Bc(e,t){return await A4(t?.signal),ur(e,t)}var Dte={amp:"&",apos:"'",gt:">",lt:"<",quot:'"'};function Zu(e){return e.replaceAll(/&(#x[\da-f]+|#\d+|[a-z]+);/gi,(t,r)=>r.startsWith("#x")||r.startsWith("#X")?String.fromCodePoint(Number.parseInt(r.slice(2),16)):r.startsWith("#")?String.fromCodePoint(Number(r.slice(1))):Dte[r]??t)}var Nte="jbrowse-msaview-taxonomy-cache",ef="common-names",Lte=2,g4=ni(Nte,Lte,e=>{e.objectStoreNames.contains(ef)&&e.deleteObjectStore(ef),e.createObjectStore(ef,{keyPath:"taxid"})});function Fte(e){return oi("taxonomy cache read",async()=>{let r=(await g4()).transaction(ef,"readonly"),n=await Promise.all(e.map(o=>r.store.get(o)));return await r.done,n},[])}function Pte(e){return oi("taxonomy cache write",async()=>{let r=(await g4()).transaction(ef,"readwrite");for(let n of e)await r.store.put(n);await r.done},void 0)}async function ii(e){let t=[...new Set(e)],r=new Map,n=[],o=await Fte(t);for(let a=0;a<t.length;a++){let l=t[a],c=o[a];c?r.set(l,{sciname:c.sciname,commonName:c.commonName}):n.push(l)}if(n.length===0)return r;let i=100,s=[];for(let a=0;a<n.length;a+=i){let l=n.slice(a,a+i),c=l.join(",");try{let u=await Cs(vc({db:"taxonomy",id:c,retmode:"xml"})),f=new Map,m=/<Taxon>\s*<TaxId>(\d+)<\/TaxId>/g,d;for(;(d=m.exec(u))!==null;){let p=Number(d[1]),h=d.index,y=1,b=h+d[0].length;for(;y>0&&b<u.length;){let v=u.indexOf("<Taxon>",b),B=u.indexOf("</Taxon>",b);if(B===-1)break;v!==-1&&v<B?(y++,b=v+7):(y--,b=B+8)}let C=u.slice(h,b),I=f.get(p),x=C.includes("<LineageEx>"),S=I?.includes("<LineageEx>");(!I||x&&!S)&&f.set(p,C)}for(let p of l){let h=f.get(p);if(h){let y=/<GenbankCommonName>(.*?)<\/GenbankCommonName>/.exec(h),b=/<CommonName>(.*?)<\/CommonName>/.exec(h),C=/<ScientificName>(.*?)<\/ScientificName>/.exec(h),I=y?.[1]??b?.[1],x=I&&Zu(I),S=Zu(C?.[1]??"");r.set(p,{sciname:S,commonName:x}),s.push({taxid:p,sciname:S,commonName:x})}}}catch(u){console.error("Failed to fetch taxonomy data:",u)}}return s.length>0&&await Pte(s),r}mo();mo();var y4="https://api.ncbi.nlm.nih.gov/datasets/v2",si=100;function tf(e){return e.trim().replace(/^\w+:/,"").replace(/\.\d+$/,"")}async function b4(e,t){let r=new Set;for(let n of e){let o=n.trim();if(/^\d+$/.test(o))return{geneId:o,matched:o};let i=tf(o);if(!i||r.has(i))continue;r.add(i);let a=(await Bc(bs("esearch",{db:"gene",term:`${i}[Gene Name] AND ${t}[taxid]`,retmode:"json",retmax:"1"}))).esearchresult?.idlist?.[0];if(a)return{geneId:a,matched:i}}}async function Ote(e,{taxa:t,exclude:r,limit:n=si}={}){let o=await ur(`${y4}/gene/id/${e}/orthologs?returned_content=COMPLETE`),i=new Map;for(let{gene:s}of o.reports??[]){let a=Number(s?.tax_id);if(s?.gene_id&&a!==r&&(t?.has(a)??!0)&&!i.has(a)&&i.set(a,{taxId:a,geneId:s.gene_id,scientificName:s.taxname??String(a),commonName:s.common_name}),i.size>=n)break}return[...i.values()]}var h4=150;async function C4(e){let t=new Map;for(let r=0;r<e.length;r+=h4){let n=e.slice(r,r+h4),o=await ur(`${y4}/gene/id/${n.join(",")}/product_report?page_size=${n.length}`);for(let{product:i}of o.reports??[]){let s=(i?.transcripts??[]).map(l=>({acc:l.protein?.accession_version,len:l.protein?.length??0,mane:/select/i.test(l.select_category??"")})).filter(l=>!!l.acc),a=s.find(l=>l.mane)??[...s].sort((l,c)=>c.len-l.len).at(0);i?.gene_id&&a&&t.set(i.gene_id,a.acc)}}return t}function x4(e){let t=new Map,r,n=[];for(let o of e.split(`
90
+ `))o.startsWith(">")?(r&&t.set(r,n.join("")),r=o.slice(1).split(/\s+/)[0],n=[]):n.push(o.trim());return r&&t.set(r,n.join("")),t}function Gte(e){return e.replace(/[^A-Za-z0-9]+/g,"_").replace(/^_+|_+$/g,"")}function xs(e){let t=new Set;return e.map(r=>{let n=Gte(r)||"row",o=n,i=1;for(;t.has(o);)i+=1,o=`${n}_${i}`;return t.add(o),o})}async function E4(e){let t=(await C4([e])).get(e);if(!t)return;let r=x4(await Cs(vc({db:"protein",id:t,rettype:"fasta",retmode:"text"}))).get(t);return r?{accession:t,sequence:r}:void 0}async function w4({geneId:e,taxa:t,exclude:r,limit:n,onProgress:o}){o("Finding orthologs across species...");let i=await Ote(e,{taxa:t,exclude:r,limit:n});if(i.length<2)throw new Error(`Only ${i.length} ortholog(s) found for this gene \u2014 not enough to align`);o("Selecting a representative protein per species...");let s=await C4(i.map(m=>m.geneId)),a=i.filter(m=>s.has(m.geneId));if(a.length<2)throw new Error("Could not resolve representative proteins for the orthologs");o(`Fetching ${a.length} protein sequences...`);let l=a.map(m=>s.get(m.geneId)),c=x4(await Cs(...p4({db:"protein",id:l.join(","),rettype:"fasta",retmode:"text"}))),u=xs(a.map(m=>m.commonName??m.scientificName)),f=a.map((m,d)=>{let p=s.get(m.geneId);return{taxId:m.taxId,label:u[d],scientificName:m.scientificName,commonName:m.commonName,geneId:m.geneId,protein:p,sequence:c.get(p)??""}}).filter(m=>m.sequence);if(f.length<2)throw new Error("Could not fetch protein sequences for the orthologs");return f}var UA="https://rest.uniprot.org";var Hte="keyword:KW-1185",Ute=/^(?:[OPQ][0-9][A-Z0-9]{3}[0-9]|[A-NR-Z][0-9](?:[A-Z][A-Z0-9]{2}[0-9]){1,2})(?:-\d+)?$/,ME="accession,id,reviewed,organism_name,organism_id,protein_name,sequence";function S4(e){let{primaryAccession:t,uniProtkbId:r,organism:n,sequence:o}=e;if(!(!t||!n?.taxonId||!o?.value))return{accession:t,id:r??t,reviewed:/\breviewed\b/i.test(e.entryType??""),taxId:n.taxonId,scientificName:n.scientificName??String(n.taxonId),commonName:n.commonName,title:e.proteinDescription?.recommendedName?.fullName?.value??e.proteinDescription?.submissionNames?.[0]?.fullName?.value,sequence:o.value}}function I4(e){return(e.results??[]).flatMap(t=>{let r=S4(t);return r?[r]:[]})}function RE(e,t){return Number(t.reviewed)-Number(e.reviewed)||t.sequence.length-e.sequence.length}async function kE(e,t,r){for(let n of e){let o=tf(n);if(!o)continue;if(Ute.test(o)){let l=await ur(`${UA}/uniprotkb/${o}?fields=${ME}`,{signal:r}),c=S4(l);if(c)return c;continue}let i=`gene_exact:"${o.replaceAll('"',"")}" AND organism_id:${t}`,s=await ur(`${UA}/uniprotkb/search?query=${encodeURIComponent(i)}&fields=${ME}&size=25`,{signal:r}),[a]=I4(s).sort(RE);if(a)return a}}async function $te(e,t,r){let n=`(uniprot_id:${e}) AND (identity:${t/100})`,i=(await ur(`${UA}/uniref/search?query=${encodeURIComponent(n)}&fields=id,count&size=1`,{signal:r})).results?.[0];return i?.id?{id:i.id,memberCount:i.memberCount}:void 0}var Vte=500,jte=5e3;function Wte(e){let t=e.headers.get("link")??"";return/<([^>]+)>;\s*rel="next"/.exec(t)?.[1]}async function qte({clusterId:e,identity:t,referenceProteomesOnly:r=!0,taxa:n,exclude:o,limit:i=si,onProgress:s,signal:a}){let l=[`uniref_cluster_${t}:${e}`,...r?[Hte]:[]].join(" AND "),c=`${UA}/uniprotkb/search?query=${encodeURIComponent(l)}&fields=${ME}&size=${Vte}&format=json`,u=new Map,f=0,m;for(;c&&f<jte;){let d=await FA(c,{signal:a});m??=Number(d.headers.get("x-total-results"))||void 0;let p=I4(await d.json());f+=p.length;for(let h of p){if(h.taxId===o||n&&!n.has(h.taxId))continue;let y=u.get(h.taxId);(!y||RE(h,y)<0)&&u.set(h.taxId,h)}if(s?.(`Read ${f}${m?` of ${m}`:""} cluster members, ${u.size} species...`),n&&[...n].every(h=>u.has(h)||h===o))break;c=p.length?Wte(d):void 0}return{total:m,rows:[...u.values()].sort(RE).slice(0,i)}}async function v4({candidates:e,taxId:t,identity:r=50,referenceProteomesOnly:n=!0,taxa:o,exclude:i,limit:s=si,onProgress:a,signal:l}){a("Resolving the query at UniProt...");let c=await kE(e,t,l);if(!c)throw new Error(`UniProt has no entry for ${e.join(", ")} in taxon ${t}. Try the BLAST tab, which needs no gene identifier.`);a(`Finding the UniRef${r} cluster of ${c.id}...`);let u=await $te(c.accession,r,l);if(!u)throw new Error(`${c.accession} is in no UniRef${r} cluster`);let{total:f,rows:m}=await qte({clusterId:u.id,identity:r,referenceProteomesOnly:n,taxa:o,exclude:i,limit:s,onProgress:a,signal:l});if(m.length<1)throw new Error(`${u.id} has no other ${n?"reference-proteome ":""}member to align ${c.id} against`);let d=xs(m.map(p=>p.commonName??p.scientificName));return{query:c,clusterId:u.id,total:f,rows:m.map((p,h)=>({taxId:p.taxId,label:d[h],scientificName:p.scientificName,commonName:p.commonName,geneId:p.id,protein:p.accession,sequence:p.sequence}))}}function $A(e){return e.rowMap.has(e.querySeqName)}function QE(e){return e?typeof e.toJSON=="function"?e.toJSON():e:{}}function B4(e){return typeof e=="string"?e:void 0}function VA(e){let t=QE(e);return B4(t.name)??B4(t.id)}function _E(e,t){let{querySeqName:r}=e;if(t<0)return;let n=e.seqPosToVisibleCol(r,t);return n!==void 0&&e.visibleColToSeqPos(r,n)===t?n:void 0}function jA(e,t){return _E(e,t-e.querySeqOffset)}function Es(e){return!!e&&typeof e=="object"&&"hoverPosition"in e&&!!e.hoverPosition}function T4(e){return/AF-([A-Z0-9]+)-F\d+/.exec(e)?.[1]}function WA(e){return typeof e=="string"?e:void 0}async function zte(e,t){let r=e.blastParams;if(r.proteinSequence)return{sequence:ri(r.proteinSequence),name:e.querySeqName};if(r.accession){t.onProgress(`Fetching ${r.accession} from UniProt...`);let n=await kE([r.accession],0,t.signal);if(!n)throw new Error(`UniProt has no entry ${r.accession}`);let o=`${n.id}_query`;return t.act(()=>{e.setQuerySeqName(o)}),{sequence:n.sequence,name:o}}throw new Error("No query: a search needs a proteinSequence, a UniProt accession, or a connectedTranscript to translate")}async function M4({self:e,scope:t}){let r=e.blastParams,{selectedTranscript:n,maxHits:o,searchProgram:i="blastp"}=r,{sequence:s,name:a}=await zte(e,t),{onProgress:l,onRid:c,signal:u}=t,{hits:f,queryRow:m,rid:d}=await o4[i]({query:s,database:r.blastDatabase,maxHits:o,onProgress:l,onRid:c,signal:u});if(f.length===0)throw new Error("No hits found");l("Fetching species taxonomy info...");let p=await ii(f.map(S=>S.taxid).filter(S=>S!==void 0)),{msa:h,treeMetadata:y}=u4({hits:f,query:s,queryRow:m,taxonomyInfo:p,querySeqName:a}),{msa:b,tree:C}=m?{msa:h,tree:""}:await HA({algorithm:r.msaAlgorithm??"browser",sequence:h,onProgress:l,signal:u}),I=QE(n),x=JSON.stringify(y);return await j3({proteinSequence:s,blastDatabase:r.blastDatabase,msaAlgorithm:m?void 0:r.msaAlgorithm??"browser",searchProgram:r.searchProgram,maxHits:o,msa:b,tree:C,treeMetadata:x,rid:d??"",geneId:WA(I.parentId),transcriptId:WA(I.uniqueId),transcriptName:VA(n),geneName:WA(I.gene_name)??WA(I.parentId)}),{msa:b,tree:C,treeMetadata:x}}mo();var Q4="https://pantherdb.org/services/oai/pantherdb",Yte="https://rest.uniprot.org/uniprotkb";function Jte(e){return(e.search?.output?.genomes?.genome??[]).flatMap(r=>r.short_name&&r.taxon_id?[{code:r.short_name,taxId:r.taxon_id,name:r.name??r.short_name,longName:r.long_name??r.short_name}]:[])}function R4(e){let[t,...r]=(e??"").split("|"),n=r.find(i=>i.startsWith("UniProtKB="))?.slice(10),o=r.find(i=>!i.startsWith("UniProtKB="))??n;return t&&n&&o?{code:t,accession:n,geneRef:o}:void 0}function Kte(e){let t=e.search?.mapping,r=t?.mapped,n=Array.isArray(r)?r:r?[r]:[],o=[],i;for(let s of n){i??=R4(s.gene);let a=R4(s.target_gene);a&&(s.ortholog==="LDO"||s.ortholog==="O")&&o.push({...a,symbol:s.target_gene_symbol===void 0?void 0:String(s.target_gene_symbol),type:s.ortholog})}return{unmapped:!!t?.unmapped_ids,query:i,hits:o}}function Xte(e){let t=new Map;for(let r of e){let n=t.get(r.code);(!n||n.type==="O"&&r.type==="LDO")&&t.set(r.code,r)}return[...t.values()]}function Zte(e){let t=new Map;for(let r of e.results??[])r.primaryAccession&&r.sequence?.value&&t.set(r.primaryAccession,r.sequence.value);return t}var DE;function ere(){return DE??=ur(`${Q4}/supportedgenomes`).then(Jte).catch(e=>{throw DE=void 0,e}),DE}var k4=100;async function tre(e){let t=new Map;for(let r=0;r<e.length;r+=k4){let n=e.slice(r,r+k4),o=await ur(`${Yte}/accessions?accessions=${n.join(",")}&fields=accession,sequence&format=json`);for(let[i,s]of Zte(o))t.set(i,s)}return t}async function rre(e,t,r){let n;for(let o of e){let i=tf(o);if(!i)continue;let s=new URLSearchParams({geneInputList:i,organism:String(t),orthologType:"all"});r&&s.set("targetOrganism",r.map(l=>l.taxId).join(","));let a=Kte(await ur(`${Q4}/ortholog/matchortho?${s.toString()}`));if(!a.unmapped&&(n??=i,a.query))return{...a,matched:i}}return n===void 0?void 0:{matched:n,hits:[],query:void 0}}async function _4({candidates:e,taxId:t,taxa:r,exclude:n,limit:o=si,onProgress:i}){let s=await ere(),a=new Map(s.map(x=>[x.taxId,x])),l=new Map(s.map(x=>[x.code,x])),c=a.get(t);if(!c)throw new Error(`PANTHER has no reference proteome for taxon ${t}. NCBI orthologs cover vertebrates and insects; try that source.`);let u=r?[...r].flatMap(x=>{let S=a.get(x);return S&&x!==n?[S]:[]}):void 0;i("Matching orthologs at PANTHER...");let f=await rre(e,t,u);if(!f)throw new Error(`PANTHER has no entry for ${e.join(", ")} in ${c.longName}. Try the NCBI BLAST tab, which needs no gene identifier.`);let m=new Map(u?.map((x,S)=>[x.taxId,S])),d=Xte(f.hits).map(x=>({hit:x,genome:l.get(x.code)})).filter(x=>!!x.genome&&x.genome.taxId!==n&&(u?m.has(x.genome.taxId):!0)).sort((x,S)=>u?m.get(x.genome.taxId)-m.get(S.genome.taxId):0).slice(0,o);if(d.length<2)throw new Error(`Only ${d.length} PANTHER ortholog(s) found for ${f.matched} \u2014 not enough to align`);i(`Fetching ${d.length} protein sequences from UniProt...`);let[p,h]=await Promise.all([nre(d.map(x=>x.genome.taxId)),tre([...f.query?[f.query.accession]:[],...d.map(x=>x.hit.accession)])]),y=d.map(({hit:x,genome:S})=>{let v=p.get(S.taxId);return{hit:x,genome:S,name:v?v.commonName??v.sciname:S.name,scientificName:v?.sciname||S.longName,commonName:v?.commonName}}),b=xs(y.map(x=>x.name)),C=y.map(({hit:x,genome:S,scientificName:v,commonName:B},Q)=>({taxId:S.taxId,label:b[Q],scientificName:v,commonName:B,geneId:x.geneRef,protein:x.accession,sequence:h.get(x.accession)??""})).filter(x=>x.sequence);if(C.length<2)throw new Error("Could not fetch protein sequences for the orthologs");let I=f.query&&h.get(f.query.accession);return{matched:f.matched,query:f.query&&I?{...f.query,sequence:I}:void 0,rows:C}}async function nre(e){try{return await ii(e)}catch(t){return console.warn("[msaview-orthologs] taxonomy name lookup failed:",t),new Map}}async function D4({self:e,scope:t}){let{taxId:r,taxa:n,maxSpecies:o,geneCandidates:i,msaAlgorithm:s,proteinSequence:a,source:l="ncbi",identity:c,referenceProteomesOnly:u}=e.orthologParams,{onProgress:f,act:m,signal:d}=t,p={taxId:r,geneCandidates:i,taxa:n?new Set(n):void 0,exclude:r,limit:o,onProgress:f},{geneId:h,representative:y,rows:b}=l==="panther"?await are(p):l==="uniref"?await sre({...p,identity:c,referenceProteomesOnly:u,signal:d}):await ore(p),C=a?ri(a):y?.sequence;if(!C)throw new Error(`No query protein: none was supplied and ${ire[l]} returned no representative protein for gene ${h}.`);let I=await cre(r,b);m(()=>{e.setQuerySeqName(I)});let x={[I]:ure(e,h,C,y)};for(let v of b)x[v.label]=fre(v);return{...await HA({algorithm:s,sequence:[`>${I}
90
91
  ${C}`,...b.map(v=>`>${v.label}
91
92
  ${v.sequence}`)].join(`
92
- `),onProgress:f,signal:d}),treeMetadata:JSON.stringify(x)}}async function jte({taxId:e,geneCandidates:t,onProgress:r,...n}){r("Resolving gene at NCBI...");let o=await u4(t,e);if(!o)throw new Error(`Could not resolve any of ${t.join(", ")} to an NCBI gene in taxon ${e}. Try the NCBI BLAST tab, which needs no gene identifier.`);let i=await Jte(o.geneId),s=await p4({geneId:o.geneId,onProgress:r,...n});return{geneId:o.geneId,representative:i,rows:s}}var Wte={ncbi:"NCBI",panther:"PANTHER",uniref:"UniProt"};async function qte({geneCandidates:e,identity:t,referenceProteomesOnly:r,signal:n,...o}){let i=await h4({candidates:e,identity:t,referenceProteomesOnly:r,signal:n,...o});return{geneId:i.query.id,representative:{accession:i.query.accession,sequence:i.query.sequence},rows:i.rows}}async function zte({geneCandidates:e,...t}){let r=await S4({candidates:e,...t});return{geneId:r.query?.geneRef??r.matched,representative:r.query,rows:r.rows}}async function Yte(e,t){let r;try{let n=(await ii([e])).get(e);r=n?.commonName??n?.sciname}catch(n){console.warn("[msaview-orthologs] taxonomy name lookup failed:",n)}return xs([...t.map(n=>n.label),`${r??"query"}_query`]).at(-1)}async function Jte(e){try{return await m4(e)}catch(t){console.warn("[msaview-orthologs] query protein lookup failed:",t);return}}function Kte(e,t,r,n){let o={"Gene ID":t},i=$A(e.orthologParams?.selectedTranscript);return i&&(o.Transcript=i),n?.sequence===r&&(o.Accession=n.accession),o}function Xte(e){let t={"Scientific name":e.scientificName,Accession:e.protein,"Gene ID":e.geneId};return e.commonName&&(t["Common name"]=e.commonName),t}e6();var r6=g(CA());async function n6({location:e,name:t}){let r=i=>(0,r6.openLocation)({uri:i,locationType:"UriLocation"}),n=await r(`${e.uri}.idx`).readFile("utf8"),o=Hre(n,t);if(o){let s=await new _c({filehandle:r(e.uri),gziFilehandle:r(`${e.uri}.gzi`)}).read(o.length,o.offset);return new TextDecoder().decode(s).trim()}}var t6=e=>e.replace(/\.\d+$/,"");function Hre(e,t){let r=t6(t);for(let n of e.split(`
93
- `)){let[o,i,s]=n.split(" ");if(o&&t6(o)===r)return{offset:Number(i),length:Number(s)}}}var o6=g(je());function i6({model:e}){let{assemblyManager:t,hovered:r}=(0,o6.getSession)(e),{transcriptToMsaMap:n,connectedView:o,mafRegion:i}=e;if(!o?.initialized||!Es(r)||!UA(e))return;let{coord:s,refName:a}=r.hoverPosition,l=s-1,c=t.get(i?.assemblyName??o.assemblyNames[0]??""),u=m=>(c?.initialized?c.getCanonicalRefName(m):void 0)??m,f=u(a);if(i)return f!==u(i.refName)||!o.assemblyNames.includes(i.assemblyName)||l<i.start||l>=i.end?void 0:kE(e,l-i.start);if(n&&f===u(n.refName)){let m=n.g2p[l];if(m!==void 0)return VA(e,m)}}var Ure="jbrowse-msaview-domain-cache",og="domains",$re=1,s6=ni(Ure,$re,e=>{e.objectStoreNames.contains(og)||e.createObjectStore(og,{keyPath:"accession"})});function a6(e){return oi("domain cache read",async()=>{let r=(await s6()).transaction(og,"readonly"),n=await Promise.all(e.map(o=>r.store.get(o)));return await r.done,n},[])}function c6(e){return oi("domain cache write",async()=>{let r=(await s6()).transaction(og,"readwrite");for(let n of e)await r.store.put(n);await r.done},void 0)}function ui(e,t){let r=new RegExp(`<${t}>(.*?)</${t}>`,"s").exec(e)?.[1];return r===void 0?void 0:Zu(r)}function Vre(e){let t={},r=/<GBQualifier>([\s\S]*?)<\/GBQualifier>/g,n;for(;(n=r.exec(e))!==null;){let o=ui(n[1],"GBQualifier_name"),i=ui(n[1],"GBQualifier_value");o&&i!==void 0&&t[o]===void 0&&(t[o]=i)}return t}function jre(e){let t=[],r=[],n=/<GBInterval>([\s\S]*?)<\/GBInterval>/g,o;for(;(o=n.exec(e))!==null;){let i=o[1],s=ui(i,"GBInterval_from"),a=ui(i,"GBInterval_to"),l=ui(i,"GBInterval_point");s&&a?(t.push(Number(s)),r.push(Number(a))):l&&(t.push(Number(l)),r.push(Number(l)))}return t.length>0?{start:Math.min(...t),end:Math.max(...r)}:void 0}var Wre=2;function qre(e){let t=ui(e,"GBFeature_key"),r=Vre(e),n=r.db_xref,o=jre(e);if((t==="Region"||t==="Site")&&n?.startsWith("CDD:")&&o&&o.end-o.start+1>=Wre){let i=n.replace("CDD:",""),s=t==="Region",a=r.note?.split(/[[(]/)[0]?.trim(),l=s?r.region_name??i:a||r.site_type||"site",c=s?i:`${i}:${l}`;return{signature:{entry:{name:l,description:r.note??l,accession:c}},locations:[o]}}}function zre(e){let t=new Map,r=/<GBSeq>([\s\S]*?)<\/GBSeq>/g,n;for(;(n=r.exec(e))!==null;){let o=n[1],i=[],s=/<GBFeature>([\s\S]*?)<\/GBFeature>/g,a;for(;(a=s.exec(o))!==null;){let l=qre(a[1]);l&&i.push(l)}for(let l of[ui(o,"GBSeq_accession-version"),ui(o,"GBSeq_primary-accession")])l&&t.set(l,i)}return t}async function l6(e){let t=[...new Set(e)].filter(Boolean),r=new Map,n=await a6(t),o=[];t.forEach((a,l)=>{let c=n[l];c?r.set(a,c.matches):o.push(a)});let i=[],s=100;for(let a=0;a<o.length;a+=s){let l=o.slice(a,a+s),c=await Cs(vc({db:"protein",id:l.join(","),rettype:"gp",retmode:"xml"})),u=zre(c);for(let f of l){let m=u.get(f);m!==void 0&&(r.set(f,m),i.push({accession:f,matches:m}))}}return i.length>0&&await c6(i),r}async function u6(e){let t=e.data.treeMetadata;if(!t)throw new Error("No sequence metadata available to look up domains");let r=JSON.parse(t),n=Object.entries(r).map(([s,a])=>({rowName:s,accession:a.Accession})).filter(s=>!!s.accession);if(n.length===0)throw new Error("No NCBI accessions found in alignment rows");e.setProgress(`Fetching protein domains from NCBI for ${n.length} sequences...`);let o=await l6(n.map(s=>s.accession)),i=n.flatMap(({rowName:s,accession:a})=>(o.get(a)??[]).flatMap(({signature:l,locations:c})=>l.entry?c.map(({start:u,end:f})=>({id:s,accession:l.entry.accession,name:l.entry.name,description:l.entry.description,start:u,end:f})):[]));if(i.length===0)throw new Error("No CDD domain annotations found for these proteins");e.setAnnotations(i)}var Yre="jbrowse-msaview-data",Jre=1,vs="msa-data",ig=ni(Yre,Jre,e=>{e.objectStoreNames.contains(vs)||e.createObjectStore(vs,{keyPath:"id"}).createIndex("timestamp","timestamp",{unique:!1})});function f6(){return`msa-${Date.now()}-${Math.random().toString(36).slice(2,11)}`}async function d6(e,t){try{let r=await ig(),n={...t,id:e,timestamp:Date.now()};return await r.put(vs,n),!0}catch(r){return console.warn("Failed to store MSA data:",r),!1}}async function m6(e){try{let t=await ig(),r=await t.get(vs,e);if(!r)return;try{await t.put(vs,{...r,timestamp:Date.now()})}catch(s){console.warn("Failed to refresh MSA data timestamp:",s)}let{id:n,timestamp:o,...i}=r;return i}catch(t){console.warn("Failed to retrieve MSA data:",t);return}}async function p6(e){try{await(await ig()).delete(vs,e)}catch(t){console.warn("Failed to delete MSA data:",t)}}async function A6(e=10080*60*1e3){try{let t=await ig(),r=Date.now()-e,i=await t.transaction(vs,"readwrite").store.index("timestamp").openCursor(IDBKeyRange.upperBound(r)),s=0;for(;i;)await i.delete(),s++,i=await i.continue();return s}catch(t){return console.warn("Failed to cleanup old MSA data:",t),0}}var g6=g(je()),h6=g(Hr());mo();function Kre(e){if(!(e.rows.length<2))try{e.calculateNeighborJoiningTreeFromMSA()}catch(t){console.error(t);try{(0,g6.getSession)(e).notify(`The alignment loaded, but no tree was built. ${t instanceof Error?t.message:String(t)}`,"warning")}catch(r){console.error(r)}}}function ow(e){(0,h6.untracked)(()=>{Xre(e)})}function Xre({self:e,message:t,launch:r,onLaunched:n}){e.launchController?.abort();let o=new AbortController,{signal:i}=o;e.setLaunchController(o);let s=l=>{i.aborted||l()},a={signal:i,act:s,onProgress:l=>{s(()=>{e.setProgress(l)})},onRid:l=>{s(()=>{e.setRid(l)})}};(async()=>{try{s(()=>{e.setProgress(t),e.setError(void 0)});let l=await r(a);s(()=>{e.setData(l),n()}),l.tree||s(()=>{Kre(e)})}catch(l){FA(l)||(s(()=>{e.setError(l)}),console.error(l))}finally{s(()=>{e.setProgress(""),e.launchController===o&&e.setLaunchController(void 0)})}})()}function Zre(e){let t=e;return t.type==="ProteinView"&&Array.isArray(t.structures)}function y6(e){return e.filter(Zre)}var ene="This view's alignment is no longer in browser storage. Stored alignments are kept for 7 days after they were last used, and are lost when site data is cleared.",tne=" Retry runs the original search again and rebuilds it.",rne=" Relaunch it from the gene to rebuild it.";function x6(e){let{dataStoreId:t,rows:r}=e;t&&r.length===0&&(async()=>{try{e.setLoadingStoredData(!0);let n=await m6(t);n?(0,sg.transaction)(()=>{n.msa&&e.setMSA(n.msa),n.tree&&e.setTree(n.tree),n.treeMetadata&&e.setTreeMetadata(n.treeMetadata),n.gff&&e.setGFF(n.gff),e.setLastStoredData(E6(e))}):(0,sg.transaction)(()=>{e.setDataStoreId(void 0),e.setError(new Error(ene+(e.blastParams??e.orthologParams?tne:rne)))})}catch(n){console.error("Failed to load MSA data from IndexedDB:",n)}finally{e.setLoadingStoredData(!1)}})()}function E6(e){let{msa:t,tree:r,treeMetadata:n,gff:o}=e.data;return{msa:t,tree:r,treeMetadata:n,gff:o}}function nne(e,t){return!!e&&e.msa===t.msa&&e.tree===t.tree&&e.treeMetadata===t.treeMetadata&&e.gff===t.gff}function w6(e){let{rows:t,dataStoreId:r,isStoringData:n,lastStoredData:o,init:i}=e,s=E6(e);t.length===0||n||e.msaFilehandle||e.treeFilehandle||i?.msaIndexedLocation||!(s.msa||s.tree)||nne(o,s)||(e.setIsStoringData(!0),(async()=>{try{let a=r??f6();await d6(a,s)&&e.setDataStoreId(a)}catch(a){console.error("Failed to store MSA data to IndexedDB:",a)}finally{(0,sg.transaction)(()=>{e.setLastStoredData(s),e.setIsStoringData(!1)})}})())}function S6(e){e.orthologParams&&!e.launchCompleted&&!I6(e)&&ow({self:e,message:"Resolving orthologs",launch:t=>I4({self:e,scope:t}),onLaunched:()=>{e.setLaunchCompleted(!0)}})}function I6(e){return!!e.connectedTranscript&&!e.connectedFeature}function v6(e){e.blastParams&&!e.launchCompleted&&!I6(e)&&ow({self:e,message:"Submitting query",launch:t=>C4({self:e,scope:t}),onLaunched:()=>{e.setLaunchCompleted(!0)}})}function B6(e){let{rows:t,domainsRequested:r,annotations:n}=e,o=e.data.treeMetadata?.includes('"Accession"')??!1;t.length>0&&o&&n.length===0&&!r&&(e.setDomainsRequested(!0),(async()=>{try{await u6(e)}catch(i){console.error("[msaview-domains] auto-load failed:",i)}finally{e.setProgress("")}})())}function T6(e){let{init:t}=e;if(t){let{msaUrl:r,msaIndexedLocation:n,msaName:o,querySeqName:i}=t,s=!!(n&&o);if(s&&e.data.msa)return;(async()=>{try{if(e.setError(void 0),r){let a=b4(r);a&&(e.setUniprotId(a),e.setQuerySeqName("query"))}if(i&&e.setQuerySeqName(i),r)e.setMSAFilehandle({uri:r,locationType:"UriLocation"});else if(n&&o){let a=await n6({location:n,name:o});if(a)e.setMSA(a);else throw new Error(`No alignment named ${o} in ${n.uri}`)}s||e.setInit(void 0)}catch(a){e.setError(a),console.error(a)}})()}}function M6(e){let t=!1;return()=>{let r=i6({model:e});r!==void 0?(e.setMousePos(r),t=!0):t&&(e.setMousePos(void 0),t=!1)}}function b6(e,t){let{connectedViewId:r,transcriptToMsaMap:n}=e;if(!n||!UA(e))return[];let{g2p:o}=n,i=new Set;for(let s of y6((0,C6.getSession)(e).views))for(let a of s.structures)if(a.connectedViewId===r)for(let l of a[t]??[])for(let c=l.start;c<l.end;c++){let u=o[c],f=u===void 0?void 0:VA(e,u);f!==void 0&&i.add(f)}return[...i]}function one(e,t){return!e||!t?e===t:e.length===t.length&&e.every((r,n)=>r===t[n])}function R6(e){let t;return()=>{let{connectedViewId:r,transcriptToMsaMap:n}=e;if(!r||!n)return;let o=b6(e,"hoverGenomeHighlights"),i=o.length?[]:b6(e,"clickGenomeHighlights"),s=e.highlightColumns??[],a=o.length?o:i.length?i:s,l=a.length>0?a:void 0;one(t,l)||(t=l,e.setHighlightedColumns(l))}}function k6(){A6().catch(e=>{console.error("Failed to cleanup old MSA data:",e)})}function Q6(e){let{region:t}=e;t&&e.viewInitialized&&e.numColumns>0&&!(e.treeFilehandle&&!e.data.tree)&&(e.zoomToRegion(t),e.setRegion(void 0))}function ag({model:e,coord:t}){let{querySeqName:r,transcriptToMsaMap:n,mafRegion:o}=e,i=e.visibleColToSeqPos(r,t);if(i===void 0)return[];if(o){let s=o.start+i;return s<o.end?[{refName:o.refName,start:s,end:s+1}]:[]}if(n){let{refName:s,p2gCodon:a}=n,l=i+(e.querySeqOffset??0);return aB(a,l)?.map(([c,u])=>({refName:s,start:c,end:u}))??[]}return[]}function _6(e){let t=ag(e),r=t[0],n=t.at(-1);return r&&n?{refName:r.refName,start:r.start,end:n.end}:void 0}var H6=g(Ai()),sw=g(je()),U6=g(Rt()),ug=g(Hr());var F6=g(je());N6();r_();function ane({cds:e,sequence:t,geneticCodeId:r,translExcept:n}){let{codonTable:o,starts:i}=gC(r);return D6({cds:e,sequence:t,codonTable:o,starts:i,translExcept:n})}function L6(e){return`${e.start}-${e.end}`}function cne(e){return e.filter((t,r,n)=>!r||L6(t)!==L6(n[r-1]))}function lne(e,t){return e.map(r=>({...r,start:t-r.end,end:t-r.start})).toSorted((r,n)=>r.start-n.start)}function cg({feature:e,seq:t,assemblyGeneticCodeId:r}){let{subfeatures:n,start:o,end:i,strand:s}=e.toJSON(),a=cne(n?.toSorted((f,m)=>f.start-m.start).map(f=>({...f,start:f.start-o,end:f.end-o})).filter(f=>f.type==="CDS")??[]),l=e.get("subfeatures")?.find(f=>f.get("type")?.toLowerCase()==="cds"),c=AC(e.get("transl_table"))??AC(l?.get("transl_table"))??r,u=e.get("transl_except")??l?.get("transl_except");return ane({cds:s===-1?lne(a,t.length):a,sequence:s===-1?(0,F6.revcom)(t):t,geneticCodeId:c,translExcept:u?e_({raw:u,featureStart:o,featureLength:i-o,strand:s}):void 0})}var P6=g(Ai());async function lg({start:e,end:t,refName:r,session:n,assemblyName:o}){let{assemblyManager:i,rpcManager:s}=n,a=await i.waitForAssembly(o);if(!a)throw new Error("assembly not found");let l="getSequence",c={adapterConfig:(0,P6.getConf)(a,["sequence","adapter"]),sessionId:l,regions:[{start:e,end:t,refName:a.getCanonicalRefName(r)??r,assemblyName:o}]};return{seq:(await s.call(l,"CoreGetFeatures",c))[0]?.get("seq")??"",assemblyGeneticCodeId:une(a,r)}}function une(e,t){return e.getGeneticCodeId?.(t)}function O6(e){return e.replace(/\.\d+$/,"")}function fne(e,t){let r=O6(t);return[e.get("name"),e.get("id"),e.get("transcript_id"),e.id()].some(n=>typeof n=="string"&&(n===t||O6(n)===r))}function G6(e){return e.map(t=>({assemblyName:t.assemblyName,refName:t.refName,start:Math.floor(t.start),end:Math.ceil(t.end)}))}function dne(e){let t=G6(e.dynamicBlocks?.contentBlocks??[]),r=G6(e.displayedRegions);return t.length>0?[t,r]:[r]}function $6(e){return e.filter(t=>t.type==="FeatureTrack")}async function mne(e,t){let r=e.connectedView,n=(0,sw.getSession)(e),o="msaview-connectedTranscript",i=$6(r.tracks);for(let s of dne(r))for(let a of i){let l={adapterConfig:(0,H6.getConf)(a,"adapter"),sessionId:o,regions:s},c=await n.rpcManager.call(o,"CoreGetFeatures",l);for(let u of c){let f=pE(u).find(m=>fne(m,t));if(f)return f}}}async function pne(e,t){let{start:r,end:n,refName:o}=t.toJSON(),i=e.connectedView.assemblyNames[0],{seq:s,assemblyGeneticCodeId:a}=await lg({start:r,end:n,refName:o,assemblyName:i,session:(0,sw.getSession)(e)});return cg({seq:s,feature:t,assemblyGeneticCodeId:a})}var iw=new WeakMap;async function Ane({self:e,transcriptId:t,blastParams:r,orthologParams:n,isCurrent:o}){let i=$6(e.connectedView.tracks).length;try{e.setProgress(`Looking up ${t} in the genome view...`);let s=await mne(e,t);if(!s)throw new Error(`Transcript "${t}" was not found in the ${i} feature track(s) open in the connected genome view. Open the gene track that carries it, and make sure the view is on its locus.`);let a=await pne(e,s);if(!a)throw new Error(`Transcript "${t}" has no CDS to translate`);if(!o())return;let l=s.toJSON();(0,ug.transaction)(()=>{e.setProgress(""),r&&!r.proteinSequence&&e.setBlastParams({...r,selectedTranscript:l,proteinSequence:a}),n&&!n.proteinSequence&&e.setOrthologParams({...n,selectedTranscript:l,proteinSequence:a}),e.setConnectedFeature(l)})}catch(s){console.error(s),o()&&(e.setProgress(""),e.setError(s))}}function V6(e){let{connectedTranscript:t,connectedFeature:r,connectedView:n,blastParams:o,orthologParams:i}=e;if(!t||r||!n?.initialized||n.tracks.length===0)return;let s=(iw.get(e)??0)+1;iw.set(e,s),(0,ug.untracked)(()=>{Ane({self:e,transcriptId:t,blastParams:o,orthologParams:i,isCurrent:()=>(0,U6.isAlive)(e)&&iw.get(e)===s})})}function aw(){return Ue.types.compose(j6.BaseViewModel,vA(),Ue.types.model("MsaView",{connectedViewId:Ue.types.maybe(Ue.types.string),connectedFeature:Ue.types.frozen(),connectedTranscript:Ue.types.maybe(Ue.types.string),blastParams:Ue.types.frozen(),orthologParams:Ue.types.frozen(),querySeqName:"QUERY",querySeqOffset:0,uniprotId:Ue.types.maybe(Ue.types.string),zoomToBaseLevel:!1,init:Ue.types.frozen(),dataStoreId:Ue.types.maybe(Ue.types.string),launchCompleted:!1,mafRegion:Ue.types.frozen(),region:Ue.types.frozen()})).volatile(()=>({rid:void 0,progress:"",loadingStoredData:!1,isStoringData:!1,lastStoredData:void 0,launchController:void 0,domainsRequested:!1})).views(e=>({get transcriptToMsaMap(){return e.connectedFeature?sB(e.connectedFeature):void 0},get connectedView(){let{views:t}=(0,W6.getSession)(e);return t.find(r=>r.id===e.connectedViewId)}})).views(e=>({get connectedHoverHighlights(){let{mouseCol:t}=e;return t===void 0?[]:ag({model:e,coord:t})},get connectedClickHighlights(){let{mouseClickCol:t}=e;return t===void 0?[]:ag({model:e,coord:t})},get connectedHighlights(){return[...this.connectedHoverHighlights,...this.connectedClickHighlights]}})).views(e=>({get hostRestoresData(){let{msaIndexedLocation:t,msaName:r}=e.init??{};return e.hostCarriesData||!!(t&&r)}})).actions(e=>({setZoomToBaseLevel(t){e.zoomToBaseLevel=t},setProgress(t){e.progress=t},setRid(t){e.rid=t},setBlastParams(t){e.blastParams=t},setConnectedFeature(t){e.connectedFeature=t},setOrthologParams(t){e.orthologParams=t},setInit(t){e.init=t},setQuerySeqName(t){e.querySeqName=t},setQuerySeqOffset(t){e.querySeqOffset=t},setUniprotId(t){e.uniprotId=t},setDataStoreId(t){e.dataStoreId=t},setLaunchCompleted(t){e.launchCompleted=t},setMafRegion(t){e.mafRegion=t},setRegion(t){e.region=t},setLoadingStoredData(t){e.loadingStoredData=t},setIsStoringData(t){e.isStoringData=t},setLastStoredData(t){e.lastStoredData=t},setLaunchController(t){e.launchController=t},cancelLaunch(){e.launchController?.abort(),e.launchController=void 0,e.blastParams=void 0,e.orthologParams=void 0,e.init=void 0,e.launchCompleted=!1,e.progress="",e.rid=void 0,e.error=void 0},retryLaunch(){e.launchController?.abort(),e.launchController=void 0,e.progress="",e.rid=void 0,e.error=void 0,e.launchCompleted=!1,e.blastParams&&(e.blastParams={...e.blastParams}),e.orthologParams&&(e.orthologParams={...e.orthologParams}),e.init&&(e.init={...e.init})},setDomainsRequested(t){e.domainsRequested=t},handleMsaClick(t){let{connectedView:r,zoomToBaseLevel:n}=e,o=_6({model:e,coord:t});!o||!r||(n?r.navTo(o):r.centerAt(o.start,o.refName))}})).actions(e=>{let t=e.setMouseClickPos.bind(e);return{setMouseClickPos(r,n){t(r,n),r!==void 0&&e.handleMsaClick(r)}}}).actions(e=>{let t=e.reset.bind(e);return{reset(){let{displayName:r,minimized:n,zoomToBaseLevel:o,dataStoreId:i}=e;t(),r!==void 0&&e.setDisplayName(r),e.setMinimized(n),e.setZoomToBaseLevel(o),e.setDomainsRequested(!1),e.setLastStoredData(void 0),i&&p6(i)}}}).views(e=>{let t=e.menuItems.bind(e);return{menuItems(){return[...t(),{label:"Zoom to base level on 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93
+ `),onProgress:f,signal:d}),treeMetadata:JSON.stringify(x)}}async function ore({taxId:e,geneCandidates:t,onProgress:r,...n}){r("Resolving gene at NCBI...");let o=await b4(t,e);if(!o)throw new Error(`Could not resolve any of ${t.join(", ")} to an NCBI gene in taxon ${e}. Try the NCBI BLAST tab, which needs no gene identifier.`);let i=await lre(o.geneId),s=await w4({geneId:o.geneId,onProgress:r,...n});return{geneId:o.geneId,representative:i,rows:s}}var ire={ncbi:"NCBI",panther:"PANTHER",uniref:"UniProt"};async function sre({geneCandidates:e,identity:t,referenceProteomesOnly:r,signal:n,...o}){let i=await v4({candidates:e,identity:t,referenceProteomesOnly:r,signal:n,...o});return{geneId:i.query.id,representative:{accession:i.query.accession,sequence:i.query.sequence},rows:i.rows}}async function are({geneCandidates:e,...t}){let r=await _4({candidates:e,...t});return{geneId:r.query?.geneRef??r.matched,representative:r.query,rows:r.rows}}async function cre(e,t){let r;try{let n=(await ii([e])).get(e);r=n?.commonName??n?.sciname}catch(n){console.warn("[msaview-orthologs] taxonomy name lookup failed:",n)}return xs([...t.map(n=>n.label),`${r??"query"}_query`]).at(-1)}async function lre(e){try{return await E4(e)}catch(t){console.warn("[msaview-orthologs] query protein lookup failed:",t);return}}function ure(e,t,r,n){let o={"Gene ID":t},i=VA(e.orthologParams?.selectedTranscript);return i&&(o.Transcript=i),n?.sequence===r&&(o.Accession=n.accession),o}function fre(e){let t={"Scientific name":e.scientificName,Accession:e.protein,"Gene ID":e.geneId};return e.commonName&&(t["Common name"]=e.commonName),t}l6();var f6=g(CA());async function d6({location:e,name:t}){let r=i=>(0,f6.openLocation)({uri:i,locationType:"UriLocation"}),n=await r(`${e.uri}.idx`).readFile("utf8"),o=ene(n,t);if(o){let s=await new _c({filehandle:r(e.uri),gziFilehandle:r(`${e.uri}.gzi`)}).read(o.length,o.offset);return new TextDecoder().decode(s).trim()}}var u6=e=>e.replace(/\.\d+$/,"");function ene(e,t){let r=u6(t);for(let n of e.split(`
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i=n.replace("CDD:",""),s=t==="Region",a=r.note?.split(/[[(]/)[0]?.trim(),l=s?r.region_name??i:a||r.site_type||"site",c=s?i:`${i}:${l}`;return{signature:{entry:{name:l,description:r.note??l,accession:c}},locations:[o]}}}function ane(e){let t=new Map,r=/<GBSeq>([\s\S]*?)<\/GBSeq>/g,n;for(;(n=r.exec(e))!==null;){let o=n[1],i=[],s=/<GBFeature>([\s\S]*?)<\/GBFeature>/g,a;for(;(a=s.exec(o))!==null;){let l=sne(a[1]);l&&i.push(l)}for(let l of[ui(o,"GBSeq_accession-version"),ui(o,"GBSeq_primary-accession")])l&&t.set(l,i)}return t}async function y6(e){let t=[...new Set(e)].filter(Boolean),r=new Map,n=await g6(t),o=[];t.forEach((a,l)=>{let c=n[l];c?r.set(a,c.matches):o.push(a)});let i=[],s=100;for(let a=0;a<o.length;a+=s){let l=o.slice(a,a+s),c=await Cs(vc({db:"protein",id:l.join(","),rettype:"gp",retmode:"xml"})),u=ane(c);for(let f of l){let m=u.get(f);m!==void 0&&(r.set(f,m),i.push({accession:f,matches:m}))}}return i.length>0&&await h6(i),r}async function b6(e){let t=e.data.treeMetadata;if(!t)throw new Error("No sequence metadata available to look up domains");let r=JSON.parse(t),n=Object.entries(r).map(([s,a])=>({rowName:s,accession:a.Accession})).filter(s=>!!s.accession);if(n.length===0)throw new Error("No NCBI accessions found in alignment rows");e.setProgress(`Fetching protein domains from NCBI for ${n.length} sequences...`);let o=await y6(n.map(s=>s.accession)),i=n.flatMap(({rowName:s,accession:a})=>(o.get(a)??[]).flatMap(({signature:l,locations:c})=>l.entry?c.map(({start:u,end:f})=>({id:s,accession:l.entry.accession,name:l.entry.name,description:l.entry.description,start:u,end:f})):[]));if(i.length===0)throw new Error("No CDD domain annotations found for these proteins");e.setAnnotations(i)}var cne="jbrowse-msaview-data",lne=1,vs="msa-data",sg=ni(cne,lne,e=>{e.objectStoreNames.contains(vs)||e.createObjectStore(vs,{keyPath:"id"}).createIndex("timestamp","timestamp",{unique:!1})});function C6(){return`msa-${Date.now()}-${Math.random().toString(36).slice(2,11)}`}async function x6(e,t){try{let r=await sg(),n={...t,id:e,timestamp:Date.now()};return await r.put(vs,n),!0}catch(r){return console.warn("Failed to store MSA data:",r),!1}}async function E6(e){try{let t=await sg(),r=await t.get(vs,e);if(!r)return;try{await t.put(vs,{...r,timestamp:Date.now()})}catch(s){console.warn("Failed to refresh MSA data timestamp:",s)}let{id:n,timestamp:o,...i}=r;return i}catch(t){console.warn("Failed to retrieve MSA data:",t);return}}async function w6(e){try{await(await sg()).delete(vs,e)}catch(t){console.warn("Failed to delete MSA data:",t)}}async function S6(e=10080*60*1e3){try{let t=await sg(),r=Date.now()-e,i=await t.transaction(vs,"readwrite").store.index("timestamp").openCursor(IDBKeyRange.upperBound(r)),s=0;for(;i;)await i.delete(),s++,i=await i.continue();return s}catch(t){return console.warn("Failed to cleanup old MSA data:",t),0}}var I6=g(Ve()),v6=g(Hr());mo();function une(e){if(!(e.rows.length<2))try{e.calculateNeighborJoiningTreeFromMSA()}catch(t){console.error(t);try{(0,I6.getSession)(e).notify(`The alignment loaded, but no tree was built. ${t instanceof Error?t.message:String(t)}`,"warning")}catch(r){console.error(r)}}}function sw(e){(0,v6.untracked)(()=>{fne(e)})}function fne({self:e,message:t,launch:r,onLaunched:n}){e.launchController?.abort();let o=new AbortController,{signal:i}=o;e.setLaunchController(o);let s=l=>{i.aborted||l()},a={signal:i,act:s,onProgress:l=>{s(()=>{e.setProgress(l)})},onRid:l=>{s(()=>{e.setRid(l)})}};(async()=>{try{s(()=>{e.setProgress(t),e.setError(void 0)});let l=await r(a);s(()=>{e.setData(l),n()}),l.tree||s(()=>{une(e)})}catch(l){PA(l)||(s(()=>{e.setError(l)}),console.error(l))}finally{s(()=>{e.setProgress(""),e.launchController===o&&e.setLaunchController(void 0)})}})()}function dne(e){let t=e;return t.type==="ProteinView"&&Array.isArray(t.structures)}function B6(e){return e.filter(dne)}var mne="This view's alignment is no longer in browser storage. Stored alignments are kept for 7 days after they were last used, and are lost when site data is cleared.",pne=" Retry runs the original search again and rebuilds it.",Ane=" Relaunch it from the gene to rebuild it.";function R6(e){let{dataStoreId:t,rows:r}=e;t&&r.length===0&&(async()=>{try{e.setLoadingStoredData(!0);let n=await E6(t);n?(0,ag.transaction)(()=>{n.msa&&e.setMSA(n.msa),n.tree&&e.setTree(n.tree),n.treeMetadata&&e.setTreeMetadata(n.treeMetadata),n.gff&&e.setGFF(n.gff),e.setLastStoredData(k6(e))}):(0,ag.transaction)(()=>{e.setDataStoreId(void 0),e.setError(new Error(mne+(e.blastParams??e.orthologParams?pne:Ane)))})}catch(n){console.error("Failed to load MSA data from IndexedDB:",n)}finally{e.setLoadingStoredData(!1)}})()}function k6(e){let{msa:t,tree:r,treeMetadata:n,gff:o}=e.data;return{msa:t,tree:r,treeMetadata:n,gff:o}}function gne(e,t){return!!e&&e.msa===t.msa&&e.tree===t.tree&&e.treeMetadata===t.treeMetadata&&e.gff===t.gff}function Q6(e){let{rows:t,dataStoreId:r,isStoringData:n,lastStoredData:o,init:i}=e,s=k6(e);t.length===0||n||e.msaFilehandle||e.treeFilehandle||i?.msaIndexedLocation||!(s.msa||s.tree)||gne(o,s)||(e.setIsStoringData(!0),(async()=>{try{let a=r??C6();await x6(a,s)&&e.setDataStoreId(a)}catch(a){console.error("Failed to store MSA data to IndexedDB:",a)}finally{(0,ag.transaction)(()=>{e.setLastStoredData(s),e.setIsStoringData(!1)})}})())}function _6(e){e.orthologParams&&!e.launchCompleted&&!D6(e)&&sw({self:e,message:"Resolving orthologs",launch:t=>D4({self:e,scope:t}),onLaunched:()=>{e.setLaunchCompleted(!0)}})}function D6(e){return!!e.connectedTranscript&&!e.connectedFeature}function N6(e){e.blastParams&&!e.launchCompleted&&!D6(e)&&sw({self:e,message:"Submitting query",launch:t=>M4({self:e,scope:t}),onLaunched:()=>{e.setLaunchCompleted(!0)}})}function L6(e){let{rows:t,domainsRequested:r,annotations:n}=e,o=e.data.treeMetadata?.includes('"Accession"')??!1;t.length>0&&o&&n.length===0&&!r&&(e.setDomainsRequested(!0),(async()=>{try{await b6(e)}catch(i){console.error("[msaview-domains] auto-load failed:",i)}finally{e.setProgress("")}})())}function F6(e){let{init:t}=e;if(t){let{msaUrl:r,msaIndexedLocation:n,msaName:o,querySeqName:i}=t,s=!!(n&&o);if(s&&e.data.msa)return;(async()=>{try{if(e.setError(void 0),r){let a=T4(r);a&&(e.setUniprotId(a),e.setQuerySeqName("query"))}if(i&&e.setQuerySeqName(i),r)e.setMSAFilehandle({uri:r,locationType:"UriLocation"});else if(n&&o){let a=await d6({location:n,name:o});if(a)e.setMSA(a);else throw new Error(`No alignment named ${o} in ${n.uri}`)}s||e.setInit(void 0)}catch(a){e.setError(a),console.error(a)}})()}}function P6(e){let t=!1;return()=>{let r=p6({model:e});r!==void 0?(e.setMousePos(r),t=!0):t&&(e.setMousePos(void 0),t=!1)}}function T6(e,t){let{connectedViewId:r,transcriptToMsaMap:n}=e;if(!n||!$A(e))return[];let{g2p:o}=n,i=new Set;for(let s of B6((0,M6.getSession)(e).views))for(let a of s.structures)if(a.connectedViewId===r)for(let l of a[t]??[])for(let c=l.start;c<l.end;c++){let u=o[c],f=u===void 0?void 0:jA(e,u);f!==void 0&&i.add(f)}return[...i]}function hne(e,t){return!e||!t?e===t:e.length===t.length&&e.every((r,n)=>r===t[n])}function O6(e){let t;return()=>{let{connectedViewId:r,transcriptToMsaMap:n}=e;if(!r||!n)return;let o=T6(e,"hoverGenomeHighlights"),i=o.length?[]:T6(e,"clickGenomeHighlights"),s=e.highlightColumns??[],a=o.length?o:i.length?i:s,l=a.length>0?a:void 0;hne(t,l)||(t=l,e.setHighlightedColumns(l))}}function G6(){S6().catch(e=>{console.error("Failed to cleanup old MSA data:",e)})}function cg({model:e,coord:t}){let{querySeqName:r,transcriptToMsaMap:n,mafRegion:o}=e,i=e.visibleColToSeqPos(r,t);if(i===void 0)return[];if(o){let s=o.start+i;return s<o.end?[{refName:o.refName,start:s,end:s+1}]:[]}if(n){let{refName:s,p2gCodon:a}=n,l=i+(e.querySeqOffset??0);return lB(a,l)?.map(([c,u])=>({refName:s,start:c,end:u}))??[]}return[]}function H6(e){let t=cg(e),r=t[0],n=t.at(-1);return r&&n?{refName:r.refName,start:r.start,end:n.end}:void 0}var Y6=g(Ai()),cw=g(Ve()),J6=g(Rt()),fg=g(Hr());var j6=g(Ve());$6();f_();function Cne({cds:e,sequence:t,geneticCodeId:r,translExcept:n}){let{codonTable:o,starts:i}=bC(r);return U6({cds:e,sequence:t,codonTable:o,starts:i,translExcept:n})}function V6(e){return`${e.start}-${e.end}`}function xne(e){return e.filter((t,r,n)=>!r||V6(t)!==V6(n[r-1]))}function Ene(e,t){return e.map(r=>({...r,start:t-r.end,end:t-r.start})).toSorted((r,n)=>r.start-n.start)}function lg({feature:e,seq:t,assemblyGeneticCodeId:r}){let{subfeatures:n,start:o,end:i,strand:s}=e.toJSON(),a=xne(n?.toSorted((f,m)=>f.start-m.start).map(f=>({...f,start:f.start-o,end:f.end-o})).filter(f=>f.type==="CDS")??[]),l=e.get("subfeatures")?.find(f=>f.get("type")?.toLowerCase()==="cds"),c=yC(e.get("transl_table"))??yC(l?.get("transl_table"))??r,u=e.get("transl_except")??l?.get("transl_except");return Cne({cds:s===-1?Ene(a,t.length):a,sequence:s===-1?(0,j6.revcom)(t):t,geneticCodeId:c,translExcept:u?l_({raw:u,featureStart:o,featureLength:i-o,strand:s}):void 0})}var W6=g(Ai());async function ug({start:e,end:t,refName:r,session:n,assemblyName:o}){let{assemblyManager:i,rpcManager:s}=n,a=await i.waitForAssembly(o);if(!a)throw new Error("assembly not found");let l="getSequence",c={adapterConfig:(0,W6.getConf)(a,["sequence","adapter"]),sessionId:l,regions:[{start:e,end:t,refName:a.getCanonicalRefName(r)??r,assemblyName:o}]};return{seq:(await s.call(l,"CoreGetFeatures",c))[0]?.get("seq")??"",assemblyGeneticCodeId:wne(a,r)}}function wne(e,t){return e.getGeneticCodeId?.(t)}function q6(e){return e.replace(/\.\d+$/,"")}function Sne(e,t){let r=q6(t);return[e.get("name"),e.get("id"),e.get("transcript_id"),e.id()].some(n=>typeof n=="string"&&(n===t||q6(n)===r))}function z6(e){return e.map(t=>({assemblyName:t.assemblyName,refName:t.refName,start:Math.floor(t.start),end:Math.ceil(t.end)}))}function Ine(e){let t=z6(e.dynamicBlocks?.contentBlocks??[]),r=z6(e.displayedRegions);return t.length>0?[t,r]:[r]}function K6(e){return e.filter(t=>t.type==="FeatureTrack")}async function vne(e,t){let r=e.connectedView,n=(0,cw.getSession)(e),o="msaview-connectedTranscript",i=K6(r.tracks);for(let s of Ine(r))for(let a of i){let l={adapterConfig:(0,Y6.getConf)(a,"adapter"),sessionId:o,regions:s},c=await n.rpcManager.call(o,"CoreGetFeatures",l);for(let u of c){let f=gE(u).find(m=>Sne(m,t));if(f)return f}}}async function Bne(e,t){let{start:r,end:n,refName:o}=t.toJSON(),i=e.connectedView.assemblyNames[0],{seq:s,assemblyGeneticCodeId:a}=await ug({start:r,end:n,refName:o,assemblyName:i,session:(0,cw.getSession)(e)});return lg({seq:s,feature:t,assemblyGeneticCodeId:a})}var aw=new WeakMap;async function Tne({self:e,transcriptId:t,blastParams:r,orthologParams:n,isCurrent:o}){let i=K6(e.connectedView.tracks).length;try{e.setProgress(`Looking up ${t} in the genome view...`);let s=await vne(e,t);if(!s)throw new Error(`Transcript "${t}" was not found in the ${i} feature track(s) open in the connected genome view. Open the gene track that carries it, and make sure the view is on its locus.`);let a=await Bne(e,s);if(!a)throw new Error(`Transcript "${t}" has no CDS to translate`);if(!o())return;let l=s.toJSON();(0,fg.transaction)(()=>{e.setProgress(""),r&&!r.proteinSequence&&e.setBlastParams({...r,selectedTranscript:l,proteinSequence:a}),n&&!n.proteinSequence&&e.setOrthologParams({...n,selectedTranscript:l,proteinSequence:a}),e.setConnectedFeature(l)})}catch(s){console.error(s),o()&&(e.setProgress(""),e.setError(s))}}function X6(e){let{connectedTranscript:t,connectedFeature:r,connectedView:n,blastParams:o,orthologParams:i}=e;if(!t||r||!n?.initialized||n.tracks.length===0)return;let s=(aw.get(e)??0)+1;aw.set(e,s),(0,fg.untracked)(()=>{Tne({self:e,transcriptId:t,blastParams:o,orthologParams:i,isCurrent:()=>(0,J6.isAlive)(e)&&aw.get(e)===s})})}function lw(){return Ke.types.compose(Z6.BaseViewModel,vA(),Ke.types.model("MsaView",{connectedViewId:Ke.types.maybe(Ke.types.string),connectedFeature:Ke.types.frozen(),connectedTranscript:Ke.types.maybe(Ke.types.string),blastParams:Ke.types.frozen(),orthologParams:Ke.types.frozen(),querySeqName:"QUERY",querySeqOffset:0,uniprotId:Ke.types.maybe(Ke.types.string),zoomToBaseLevel:!1,init:Ke.types.frozen(),dataStoreId:Ke.types.maybe(Ke.types.string),launchCompleted:!1,mafRegion:Ke.types.frozen()})).volatile(()=>({rid:void 0,progress:"",loadingStoredData:!1,isStoringData:!1,lastStoredData:void 0,launchController:void 0,domainsRequested:!1})).views(e=>({get transcriptToMsaMap(){return e.connectedFeature?cB(e.connectedFeature):void 0},get connectedView(){let{views:t}=(0,e8.getSession)(e);return t.find(r=>r.id===e.connectedViewId)}})).views(e=>({get connectedHoverHighlights(){let{mouseCol:t}=e;return t===void 0?[]:cg({model:e,coord:t})},get connectedClickHighlights(){let{mouseClickCol:t}=e;return t===void 0?[]:cg({model:e,coord:t})},get connectedHighlights(){return[...this.connectedHoverHighlights,...this.connectedClickHighlights]}})).views(e=>({get hostRestoresData(){let{msaIndexedLocation:t,msaName:r}=e.init??{};return e.hostCarriesData||!!(t&&r)}})).actions(e=>({setZoomToBaseLevel(t){e.zoomToBaseLevel=t},setProgress(t){e.progress=t},setRid(t){e.rid=t},setBlastParams(t){e.blastParams=t},setConnectedFeature(t){e.connectedFeature=t},setOrthologParams(t){e.orthologParams=t},setInit(t){e.init=t},setQuerySeqName(t){e.querySeqName=t},setQuerySeqOffset(t){e.querySeqOffset=t},setUniprotId(t){e.uniprotId=t},setDataStoreId(t){e.dataStoreId=t},setLaunchCompleted(t){e.launchCompleted=t},setMafRegion(t){e.mafRegion=t},setLoadingStoredData(t){e.loadingStoredData=t},setIsStoringData(t){e.isStoringData=t},setLastStoredData(t){e.lastStoredData=t},setLaunchController(t){e.launchController=t},cancelLaunch(){e.launchController?.abort(),e.launchController=void 0,e.blastParams=void 0,e.orthologParams=void 0,e.init=void 0,e.launchCompleted=!1,e.progress="",e.rid=void 0,e.error=void 0},retryLaunch(){e.launchController?.abort(),e.launchController=void 0,e.progress="",e.rid=void 0,e.error=void 0,e.launchCompleted=!1,e.blastParams&&(e.blastParams={...e.blastParams}),e.orthologParams&&(e.orthologParams={...e.orthologParams}),e.init&&(e.init={...e.init})},setDomainsRequested(t){e.domainsRequested=t},handleMsaClick(t){let{connectedView:r,zoomToBaseLevel:n}=e,o=H6({model:e,coord:t});!o||!r||(n?r.navTo(o):r.centerAt(o.start,o.refName))}})).actions(e=>{let t=e.setMouseClickPos.bind(e);return{setMouseClickPos(r,n){t(r,n),r!==void 0&&e.handleMsaClick(r)}}}).actions(e=>{let t=e.reset.bind(e);return{reset(){let{displayName:r,minimized:n,zoomToBaseLevel:o,dataStoreId:i}=e;t(),r!==void 0&&e.setDisplayName(r),e.setMinimized(n),e.setZoomToBaseLevel(o),e.setDomainsRequested(!1),e.setLastStoredData(void 0),i&&w6(i)}}}).views(e=>{let t=e.menuItems.bind(e);return{menuItems(){return[...t(),{label:"Zoom to base level on click?",type:"checkbox",checked:e.zoomToBaseLevel,onClick:()=>{e.setZoomToBaseLevel(!e.zoomToBaseLevel)}}]}}}).actions(e=>({afterCreate(){G6(),(0,Ke.addDisposer)(e,()=>{e.launchController?.abort()});for(let t of[R6,Q6,X6,N6,_6,F6,L6])(0,Ke.addDisposer)(e,(0,dg.autorun)(()=>{t(e)}));(0,Ke.addDisposer)(e,(0,dg.autorun)(P6(e))),(0,Ke.addDisposer)(e,(0,dg.autorun)(O6(e)))}}))}function Dc(e){return e.type==="MsaView"}var df=g(k()),a8=g(Y());var uw=g(k()),n8=g(Ve()),fw=g(Y());var r8=g(Bt()),mg=(0,r8.makeStyles)()({highlight:{height:"100%",background:"rgba(255,255,0,0.2)",border:"1px solid rgba(50,50,0,0.2)",position:"absolute",zIndex:99,textAlign:"center",pointerEvents:"none",overflow:"hidden"}});var Mne=(0,fw.observer)(function({model:e}){let{hovered:t,views:r}=(0,n8.getSession)(e);return r.some(o=>Dc(o)&&o.connectedViewId===e.id)&&Es(t)?uw.default.createElement(Rne,{model:e,hovered:t}):null}),Rne=(0,fw.observer)(function({model:e,hovered:t}){let{classes:r}=mg(),{offsetPx:n}=e,{coord:o,refName:i}=t.hoverPosition,s=e.bpToPx({refName:i,coord:o-1}),a=e.bpToPx({refName:i,coord:o});if(s&&a){let l=Math.max(Math.abs(a.offsetPx-s.offsetPx),4),c=Math.min(s.offsetPx,a.offsetPx)-n;return uw.default.createElement("div",{className:r.highlight,style:{left:c,width:l}})}return null}),o8=Mne;var ff=g(k()),i8=g(Ve()),dw=g(Y());var kne=(0,dw.observer)(function({model:t}){let{views:r,hovered:n}=(0,i8.getSession)(t),o=r.filter(Dc).find(s=>s.connectedViewId===t.id),i=[...o?.connectedClickHighlights??[],...Es(n)?[]:o?.connectedHoverHighlights??[]];return i.length?ff.default.createElement(Qne,{model:t,highlights:i}):null}),Qne=(0,dw.observer)(function({model:e,highlights:t}){let{classes:r}=mg(),{offsetPx:n}=e;return ff.default.createElement(ff.default.Fragment,null,t.map((o,i)=>{let s=e.bpToPx({refName:o.refName,coord:o.start}),a=e.bpToPx({refName:o.refName,coord:o.end});if(s&&a){let l=Math.max(Math.abs(a.offsetPx-s.offsetPx),4),c=Math.min(s.offsetPx,a.offsetPx)-n;return ff.default.createElement("div",{key:`${o.refName}-${o.start}-${o.end}-${i}`,className:r.highlight,style:{left:c,width:l}})}return null}))}),s8=kne;var _ne=(0,a8.observer)(function({model:t}){return df.default.createElement(df.default.Fragment,null,df.default.createElement(s8,{model:t}),df.default.createElement(o8,{model:t}))}),c8=_ne;function mw(e){e.addToExtensionPoint("LinearGenomeView-TracksContainerComponent",(t,{model:r})=>{let{views:n}=(0,u8.getSession)(r);return n.some(i=>Dc(i)&&i.connectedViewId===r.id)?[...t,l8.default.createElement(c8,{key:"highlight_protein_viewer_msaview",model:r})]:t})}var y8=g(R0());var f8=g(Ai());function pw(e){let t=e.getAdapterType("BgzipFastaAdapter");return(0,f8.ConfigurationSchema)("BgzipFastaMsaAdapter",{msaRegex:{type:"string",defaultValue:"_"}},{baseConfiguration:t.configSchema})}function Aw(e){return e.addAdapterType(()=>new y8.AdapterType({name:"BgzipFastaMsaAdapter",configSchema:pw(e),adapterMetadata:{hiddenFromGUI:!0},getAdapterClass:()=>Promise.resolve().then(()=>(h8(),g8)).then(t=>t.default)}))}var kg=g(Ve());oe();var b8=g(O(),1),C8=$((0,b8.jsx)("path",{d:"M19 13h-6v6h-2v-6H5v-2h6V5h2v6h6z"}),"Add");var Dne=/gene(_segment)?$|rna$|transcript/;function Ag(e){return typeof e=="string"&&Dne.test(e.toLowerCase())}function Nne(e){return e.get("type")?.toLowerCase()==="cds"}function gg(e){return Nne(e)||!!e.get("subfeatures")?.some(gg)}function x8(e){return!!e.get("subfeatures")?.length&&!gg(e)}function E8(e){let t=e;for(let r=t.parent?.();r&&Ag(r.get("type"));r=r.parent?.())t=r;return t}var nt=g(k()),jH=g(Ye()),WH=g(Ve()),Rs=g(H());var Fr=g(k());I8();var Sg=g(H()),bH=g(Bt());wc();Ju();var 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95
96
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96
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o9.default{constructor(){super(...arguments);this.name="MsaViewPlugin";this.version=n9;this.rootConfigurationSchema=r=>({msa:(0,Nw.ConfigurationSchema)("MSA",{datasets:Lw.types.maybe(Lw.types.array((0,Nw.ConfigurationSchema)("MSAEntry",{datasetId:{type:"string",defaultValue:""},description:{type:"string",defaultValue:""},name:{type:"string",defaultValue:""},adapter:r.pluggableConfigSchemaType("adapter")})))})})}install(r){Dw(r),Rw(r),kw(r),fw(r),mw(r)}configure(r){try{(0,i9.isAbstractMenuManager)(r.rootModel)&&r.rootModel.appendToSubMenu(["Add"],{label:"Multiple sequence alignment view",icon:oB,onClick:n=>{Lc(n,{})}})}catch(n){console.error("jbrowse-plugin-msaview: could not add the Add menu item",n)}}};return k9(Soe);})();
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+ `)??"",[B]),N=Pc(M,S),G=dH(N,`${I}_${l[0]??""}`),E=b??_??C.error??c;return Xe.default.createElement(Xe.default.Fragment,null,Xe.default.createElement(Kr,{error:E},Xe.default.createElement(Se,{select:!0,label:"Select MSA dataset",value:m,onChange:R=>{d(R.target.value)}},f?.map(R=>Xe.default.createElement(Mg.MenuItem,{key:R.datasetId,value:R.datasetId},R.name))),p?Xe.default.createElement("div",{className:s.selectedContainer},!y&&Q?Xe.default.createElement(Gc.LoadingEllipses,{variant:"h6",message:`Loading MSA for ${ti(x)||I}`}):null,y?Xe.default.createElement(Gc.LoadingEllipses,{variant:"h6",message:`Loading available MSAs for (${p.name})`}):null,h?Xe.default.createElement("div",null,Xe.default.createElement(Gc.SanitizedHTML,{html:p.description}),Xe.default.createElement(en,{feature:t,...C}),M?Xe.default.createElement(Bs,{...N,querySeqName:G}):null):null):null),Xe.default.createElement(Xr,{model:e,hint:Q?Xe.default.createElement(Gc.LoadingEllipses,{message:"Loading alignment"}):B?.length&&!G?Xe.default.createElement(Mg.Typography,{color:"textSecondary",variant:"body2"},"no row matches this transcript"):Xe.default.createElement(ho,{status:v}),submitDisabled:!x||!B?.length||!G,onSubmit:R=>{x&&M&&u(()=>{Qr({view:i,feature:x,placement:R,displayName:Jr(x),treeAreaWidth:200,treeWidth:100,drawNodeBubbles:!1,labelsAlignRight:!0,showBranchLen:!1,colWidth:10,rowHeight:12,colorSchemeName:"percent_identity_dynamic",querySeqName:G,querySeqOffset:N.querySeqOffset,data:{msa:M}})})},onCancel:r}))}),VH=Ioe;var Rg=g(k());function Hc({children:e,value:t,index:r,...n}){let o=t===r,[i,s]=(0,Rg.useState)(o);return o&&!i&&s(!0),Rg.default.createElement("div",{role:"tabpanel",hidden:!o,...n},i||o?e:null)}function kw({handleClose:e,feature:t,model:r,preferredTranscriptId:n}){let o=(0,WH.getSession)(r),s=!!Bg(o.jbrowse)?.length,[a,l]=(0,nt.useState)("orthologs");return nt.default.createElement(jH.Dialog,{maxWidth:"xl",title:"Launch MSA view",open:!0,onClose:e},nt.default.createElement(O8,null,nt.default.createElement("div",{style:{display:"flex",alignItems:"center"}},nt.default.createElement(Rs.Tabs,{value:a,onChange:(c,u)=>{l(u)}},nt.default.createElement(Rs.Tab,{label:"Orthologs",value:"orthologs"}),nt.default.createElement(Rs.Tab,{label:"BLAST query",value:"ncbi_blast"}),s?nt.default.createElement(Rs.Tab,{label:"Pre-loaded MSA datasets",value:"preloaded_msa"}):null,nt.default.createElement(Rs.Tab,{label:"Manual upload",value:"manual_msa"})),nt.default.createElement(vw,null)),nt.default.createElement(Hc,{value:a,index:"orthologs"},nt.default.createElement(FH,{handleClose:e,feature:t,model:r,preferredTranscriptId:n})),nt.default.createElement(Hc,{value:a,index:"ncbi_blast"},nt.default.createElement(Iw,{handleClose:e,feature:t,model:r,preferredTranscriptId:n})),s?nt.default.createElement(Hc,{value:a,index:"preloaded_msa"},nt.default.createElement(VH,{model:r,feature:t,handleClose:e,preferredTranscriptId:n})):null,nt.default.createElement(Hc,{value:a,index:"manual_msa"},nt.default.createElement(BH,{model:r,feature:t,handleClose:e,preferredTranscriptId:n}))))}function qH(e){let t=e.contextMenuInfo,r=e.fetchFullFeature;if(t&&r)return Ag(t.item.type)?{fetchFeature:()=>r(t.item.featureId,t.displayedRegionIndex)}:void 0;let n=e.contextMenuFeature;if(!n)return;let o=E8(n);return Ag(o.get("type"))&&!x8(o)?{feature:o,preferredTranscriptId:n.id()}:void 0}function voe(e){return e.name==="LinearBasicDisplay"}function Boe(e){return e.get("name")??e.get("id")??"This feature"}function Toe(e,t){let r=(0,kg.getContainingTrack)(e),n=(0,kg.getSession)(r),{preferredTranscriptId:o}=t,i=s=>{n.queueDialog(a=>[kw,{model:r,handleClose:a,feature:s,preferredTranscriptId:o}])};if("feature"in t){i(t.feature);return}t.fetchFeature().then(s=>{s?gg(s)?i(s):n.notify(`${Boe(s)} has no coding sequence, so there is no protein to align`,"info"):n.notify("Could not load feature for MSA view","warning")}).catch(s=>{n.notifyError(`${s}`,s)})}function Moe(e){return e.views(t=>{let r=t.contextMenuItems;return{contextMenuItems(){let n=qH(t);return[...r.call(t),...n?[{label:"Launch MSA view",icon:C8,onClick:()=>{Toe(t,n)}}]:[]]}}})}function Qw(e){e.addToExtensionPoint("Core-extendPluggableElement",t=>(voe(t)&&(t.stateModel=Moe(t.stateModel)),t))}TA();function Roe({msa:e,tree:t,...r}){let n=e?.includes(`
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+ `)?e:void 0,o=t?.trimStart().startsWith("(")?t:void 0,i=n||o?{...r.data,...n?{msa:n}:{},...o?{tree:o}:{}}:r.data;return{...r,data:i,...e&&!n?{msaFileLocation:{uri:e}}:{},...t&&!o?{treeFileLocation:{uri:t}}:{},querySeqName:r.querySeqName??r.query}}function _w(e){e.addToExtensionPoint("LaunchView-MsaView",t=>{let{session:r,query:n,data:o,msaFileLocation:i,msaIndexedLocation:s,msaName:a,treeFileLocation:l,querySeqName:c,searchParams:u,...f}=Roe(t);if(!o&&!i&&!s&&!f.orthologParams&&!u)throw new Error("No MSA data, file location, orthologParams or searchParams provided when launching MSA view");let m={msaUrl:i?.uri,msaIndexedLocation:s,msaName:a,querySeqName:c};return Lc(r,{...Ny({...f,query:n}),...u?{blastParams:u}:{},data:o,...l?{treeFilehandle:{...l,locationType:"UriLocation"}}:{},...Object.values(m).some(d=>d!==void 0)?{init:m}:{}}),t})}var l9=g(k()),u9=g(YH());var Foe=(0,l9.lazy)(()=>Promise.resolve().then(()=>(c9(),a9)));function Lw(e){e.addViewType(()=>new u9.default({name:"MsaView",stateModel:lw(),ReactComponent:Foe}))}var f9="3.7.1";var Dg=class extends d9.default{constructor(){super(...arguments);this.name="MsaViewPlugin";this.version=f9;this.rootConfigurationSchema=r=>({msa:(0,Fw.ConfigurationSchema)("MSA",{datasets:Pw.types.maybe(Pw.types.array((0,Fw.ConfigurationSchema)("MSAEntry",{datasetId:{type:"string",defaultValue:""},description:{type:"string",defaultValue:""},name:{type:"string",defaultValue:""},adapter:r.pluggableConfigSchemaType("adapter")})))})})}install(r){Lw(r),Qw(r),_w(r),mw(r),Aw(r)}configure(r){try{(0,m9.isAbstractMenuManager)(r.rootModel)&&r.rootModel.appendToSubMenu(["Add"],{label:"Multiple sequence alignment view",icon:sB,onClick:n=>{Lc(n,{})}})}catch(n){console.error("jbrowse-plugin-msaview: could not add the Add menu item",n)}}};return O9(Poe);})();
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