npm - jbrowse-plugin-msaview - Versions diffs - 2.0.2 → 2.0.4 - Mend

jbrowse-plugin-msaview 2.0.2 → 2.0.4

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Files changed (57) hide show

package/dist/jbrowse-plugin-msaview.umd.production.min.js CHANGED Viewed

@@ -1,4 +1,4 @@
-"use strict";var JBrowsePluginMsaView=(()=>{var q2=Object.create;var ra=Object.defineProperty;var k2=Object.getOwnPropertyDescriptor;var T2=Object.getOwnPropertyNames;var C2=Object.getPrototypeOf,j2=Object.prototype.hasOwnProperty;var C=(e,t)=>()=>(e&&(t=e(e=0)),t);var g=(e,t)=>()=>(t||e((t={exports:{}}).exports,t),t.exports),vt=(e,t)=>{for(var r in t)ra(e,r,{get:t[r],enumerable:!0})},rm=(e,t,r,n)=>{if(t&&typeof t=="object"||typeof t=="function")for(let i of T2(t))!j2.call(e,i)&&i!==r&&ra(e,i,{get:()=>t[i],enumerable:!(n=k2(t,i))||n.enumerable});return e};var x=(e,t,r)=>(r=e!=null?q2(C2(e)):{},rm(t||!e||!e.__esModule?ra(r,"default",{value:e,enumerable:!0}):r,e)),I2=e=>rm(ra({},"__esModule",{value:!0}),e);var im=g((m$,nm)=>{nm.exports=JBrowseExports["@jbrowse/core/Plugin"]});var Se=g((v$,om)=>{om.exports=JBrowseExports["@jbrowse/core/util"]});var Q=g((_$,ki)=>{function R2(e){return e&&e.__esModule?e:{default:e}}ki.exports=R2,ki.exports.__esModule=!0,ki.exports.default=ki.exports});var um=g((b$,am)=>{am.exports=JBrowseExports["@mui/material/utils"]});var oe=g(ef=>{"use strict";"use client";Object.defineProperty(ef,"__esModule",{value:!0});Object.defineProperty(ef,"default",{enumerable:!0,get:function(){return L2.createSvgIcon}});var L2=um()});var ae=g((y$,sm)=>{sm.exports=JBrowseExports["react/jsx-runtime"]});var lm=g(na=>{"use strict";"use client";var F2=Q();Object.defineProperty(na,"__esModule",{value:!0});na.default=void 0;var D2=F2(oe()),N2=ae(),w$=na.default=(0,D2.default)((0,N2.jsx)("path",{d:"M20 2H4c-1.1 0-2 .9-2 2v16c0 1.1.9 2 2 2h16c1.1 0 2-.9 2-2V4c0-1.1-.9-2-2-2M8 20H4v-4h4zm0-6H4v-4h4zm0-6H4V4h4zm6 12h-4v-4h4zm0-6h-4v-4h4zm0-6h-4V4h4zm6 12h-4v-4h4zm0-6h-4v-4h4zm0-6h-4V4h4z"}),"GridOn")});var I=g((E$,fm)=>{fm.exports=JBrowseExports.react});var pm=g((O$,dm)=>{dm.exports=JBrowseExports["@jbrowse/core/pluggableElementTypes/ViewType"]});var Ut=g((M$,hm)=>{hm.exports=JBrowseExports["mobx-state-tree"]});var Wt=g((A$,mm)=>{mm.exports=JBrowseExports.mobx});var D=g((P$,vm)=>{vm.exports=JBrowseExports["mobx-react"]});var N=g((q$,_m)=>{_m.exports=JBrowseExports["@mui/material"]});function H2(){let e=arguments.length>0&&arguments[0]!==void 0?arguments[0]:[],t=arguments.length>1&&arguments[1]!==void 0?arguments[1]:[];return e.length!==t.length||e.some((r,n)=>!Object.is(r,t[n]))}var Xe,z2,tf,ia,bm=C(()=>{"use client";Xe=x(I()),z2=(0,Xe.createContext)(null),tf={didCatch:!1,error:null},ia=class extends Xe.Component{constructor(t){super(t),this.resetErrorBoundary=this.resetErrorBoundary.bind(this),this.state=tf}static getDerivedStateFromError(t){return{didCatch:!0,error:t}}resetErrorBoundary(){let{error:t}=this.state;if(t!==null){for(var r,n,i=arguments.length,o=new Array(i),a=0;a<i;a++)o[a]=arguments[a];(r=(n=this.props).onReset)===null||r===void 0||r.call(n,{args:o,reason:"imperative-api"}),this.setState(tf)}}componentDidCatch(t,r){var n,i;(n=(i=this.props).onError)===null||n===void 0||n.call(i,t,r)}componentDidUpdate(t,r){let{didCatch:n}=this.state,{resetKeys:i}=this.props;if(n&&r.error!==null&&H2(t.resetKeys,i)){var o,a;(o=(a=this.props).onReset)===null||o===void 0||o.call(a,{next:i,prev:t.resetKeys,reason:"keys"}),this.setState(tf)}}render(){let{children:t,fallbackRender:r,FallbackComponent:n,fallback:i}=this.props,{didCatch:o,error:a}=this.state,u=t;if(o){let f={error:a,resetErrorBoundary:this.resetErrorBoundary};if(typeof r=="function")u=r(f);else if(n)u=(0,Xe.createElement)(n,f);else if(i===null||(0,Xe.isValidElement)(i))u=i;else throw a}return(0,Xe.createElement)(z2.Provider,{value:{didCatch:o,error:a,resetErrorBoundary:this.resetErrorBoundary}},u)}}});var qe=g((T$,gm)=>{gm.exports=JBrowseExports["@jbrowse/core/ui"]});async function Ot(e,t,r){e.setError(void 0),t&&e.setMSAFilehandle(t),r&&e.setTreeFilehandle(r)}var rf=C(()=>{});var ym,wm,Sm,xm=C(()=>{ym=`CLUSTAL O(1.2.3) multiple sequence alignment
+"use strict";var JBrowsePluginMsaView=(()=>{var wP=Object.create;var qa=Object.defineProperty;var SP=Object.getOwnPropertyDescriptor;var xP=Object.getOwnPropertyNames;var EP=Object.getPrototypeOf,OP=Object.prototype.hasOwnProperty;var C=(e,t)=>()=>(e&&(t=e(e=0)),t);var g=(e,t)=>()=>(t||e((t={exports:{}}).exports,t),t.exports),dt=(e,t)=>{for(var r in t)qa(e,r,{get:t[r],enumerable:!0})},tv=(e,t,r,n)=>{if(t&&typeof t=="object"||typeof t=="function")for(let i of xP(t))!OP.call(e,i)&&i!==r&&qa(e,i,{get:()=>t[i],enumerable:!(n=SP(t,i))||n.enumerable});return e};var x=(e,t,r)=>(r=e!=null?wP(EP(e)):{},tv(t||!e||!e.__esModule?qa(r,"default",{value:e,enumerable:!0}):r,e)),MP=e=>tv(qa({},"__esModule",{value:!0}),e);var nv=g((ZZ,rv)=>{rv.exports=JBrowseExports["@jbrowse/core/Plugin"]});var Me=g((KZ,iv)=>{iv.exports=JBrowseExports["@jbrowse/core/util"]});var G=g((JZ,Yi)=>{function AP(e){return e&&e.__esModule?e:{default:e}}Yi.exports=AP,Yi.exports.__esModule=!0,Yi.exports.default=Yi.exports});var av=g((QZ,ov)=>{ov.exports=JBrowseExports["@mui/material/utils"]});var ne=g(Rf=>{"use strict";"use client";Object.defineProperty(Rf,"__esModule",{value:!0});Object.defineProperty(Rf,"default",{enumerable:!0,get:function(){return PP.createSvgIcon}});var PP=av()});var ie=g((tK,uv)=>{uv.exports=JBrowseExports["react/jsx-runtime"]});var sv=g(Ta=>{"use strict";"use client";var qP=G();Object.defineProperty(Ta,"__esModule",{value:!0});Ta.default=void 0;var TP=qP(ne()),kP=ie(),rK=Ta.default=(0,TP.default)((0,kP.jsx)("path",{d:"M20 2H4c-1.1 0-2 .9-2 2v16c0 1.1.9 2 2 2h16c1.1 0 2-.9 2-2V4c0-1.1-.9-2-2-2M8 20H4v-4h4zm0-6H4v-4h4zm0-6H4V4h4zm6 12h-4v-4h4zm0-6h-4v-4h4zm0-6h-4V4h4zm6 12h-4v-4h4zm0-6h-4v-4h4zm0-6h-4V4h4z"}),"GridOn")});var R=g((oK,cv)=>{cv.exports=JBrowseExports.react});var dv=g((aK,fv)=>{fv.exports=JBrowseExports["@jbrowse/core/pluggableElementTypes/ViewType"]});var Ge=g((uK,pv)=>{pv.exports=JBrowseExports["mobx-state-tree"]});var tr=g((sK,hv)=>{hv.exports=JBrowseExports.mobx});var D=g((lK,mv)=>{mv.exports=JBrowseExports["mobx-react"]});var B=g((cK,vv)=>{vv.exports=JBrowseExports["@mui/material"]});function IP(){let e=arguments.length>0&&arguments[0]!==void 0?arguments[0]:[],t=arguments.length>1&&arguments[1]!==void 0?arguments[1]:[];return e.length!==t.length||e.some((r,n)=>!Object.is(r,t[n]))}var rt,jP,Ff,ka,_v=C(()=>{"use client";rt=x(R()),jP=(0,rt.createContext)(null),Ff={didCatch:!1,error:null},ka=class extends rt.Component{constructor(t){super(t),this.resetErrorBoundary=this.resetErrorBoundary.bind(this),this.state=Ff}static getDerivedStateFromError(t){return{didCatch:!0,error:t}}resetErrorBoundary(){let{error:t}=this.state;if(t!==null){for(var r,n,i=arguments.length,o=new Array(i),a=0;a<i;a++)o[a]=arguments[a];(r=(n=this.props).onReset)===null||r===void 0||r.call(n,{args:o,reason:"imperative-api"}),this.setState(Ff)}}componentDidCatch(t,r){var n,i;(n=(i=this.props).onError)===null||n===void 0||n.call(i,t,r)}componentDidUpdate(t,r){let{didCatch:n}=this.state,{resetKeys:i}=this.props;if(n&&r.error!==null&&IP(t.resetKeys,i)){var o,a;(o=(a=this.props).onReset)===null||o===void 0||o.call(a,{next:i,prev:t.resetKeys,reason:"keys"}),this.setState(Ff)}}render(){let{children:t,fallbackRender:r,FallbackComponent:n,fallback:i}=this.props,{didCatch:o,error:a}=this.state,u=t;if(o){let d={error:a,resetErrorBoundary:this.resetErrorBoundary};if(typeof r=="function")u=r(d);else if(n)u=(0,rt.createElement)(n,d);else if(i===null||(0,rt.isValidElement)(i))u=i;else throw a}return(0,rt.createElement)(jP.Provider,{value:{didCatch:o,error:a,resetErrorBoundary:this.resetErrorBoundary}},u)}}});var Ae=g((dK,bv)=>{bv.exports=JBrowseExports["@jbrowse/core/ui"]});async function Ca(e,t,r){e.setError(void 0),t&&e.setMSAFilehandle(t),r&&e.setTreeFilehandle(r)}var Lf=C(()=>{});var gv,yv,wv,Sv=C(()=>{gv=`CLUSTAL O(1.2.3) multiple sequence alignment
 UniProt/Swiss-Prot|P26898|IL2RA_SHEEP      MEPSLLMWRFFVFIVVPGCVTEACHDDPPSLRNA----------MFKVLRYE----VGTM
 UniProt/Swiss-Prot|P01590|IL2RA_MOUSE      MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNA----------TFKALSYK----NGTI
 UniProt/Swiss-Prot|P41690|IL2RA_FELCA      MEPSLLLWGILTFVVVHGHVTELCDENPPDIQHA----------TFKALTYK----TGTM
@@ -11,7 +11,7 @@ UniProt/Swiss-Prot|Q8BZM1|GLMN_MOUSE       PLPLRSLLFLQLPLLGVGLNP----------------
 UniProt/Swiss-Prot|P36835|IL2_CAPHI        -----------LLGVGLNPKFLTP------------------------------------
 UniProt/Swiss-Prot|Q7JFM4|IL2_AOTVO        MLKPPLPLRSLLFLQLPLLGVGLNPKFLTPSGNEDIGGKPGTGGDFFLTSTPAGTLDVST
 UniProt/Swiss-Prot|Q29416|IL2_CANFA        --------------LFLQLSLLG-------------------------------------
-`,wm=`CLUSTAL O(1.2.4) multiple sequence alignment
+`,yv=`CLUSTAL O(1.2.4) multiple sequence alignment
 sp|P69905|HBA_HUMAN       MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG	60
@@ -27,35 +27,35 @@ sp|P13786|HBAZ_CAPHI      SKVVAAVGDAVKSIDNVTSALSKLSELHAYVLRVDPVNFKFLSHCLLVTLASHF
 sp|P69905|HBA_HUMAN       AVHASLDKFLASVSTVLTSKYR	142
 sp|P01942|HBA_MOUSE       AVHASLDKFLASVSTVLTSKYR	142
 sp|P13786|HBAZ_CAPHI      DAHAAWDKFLSIVSGVLTEKYR	142
-                           .**: ****: ** ***.***`,Sm="(((UniProt/Swiss-Prot|P26898|IL2RA_SHEEP:0.24036,(UniProt/Swiss-Prot|P41690|IL2RA_FELCA:0.17737,(UniProt/Swiss-Prot|P01589|IL2RA_HUMAN:0.03906,UniProt/Swiss-Prot|Q5MNY4|IL2RA_MACMU:0.03787):0.13033):0.04964):0.02189,UniProt/Swiss-Prot|P01590|IL2RA_MOUSE:0.23072):0.06814,(((UniProt/Swiss-Prot|Q95118|IL2RG_BOVIN:0.09600,UniProt/Swiss-Prot|P40321|IL2RG_CANFA:0.09845):0.25333,UniProt/Swiss-Prot|Q29416|IL2_CANFA:-0.35055):0.10231,(UniProt/Swiss-Prot|P26896|IL2RB_RAT:0.33631,UniProt/Swiss-Prot|Q7JFM4|IL2_AOTVO:-0.33631):0.10166):0.01607,(UniProt/Swiss-Prot|Q8BZM1|GLMN_MOUSE:0.32378,UniProt/Swiss-Prot|P36835|IL2_CAPHI:-0.32378):0.09999)"});var Be,oa,Em,Gt,V2,Om,Mm=C(()=>{Be=x(I()),oa=x(N()),Em=x(D());xm();rf();Gt=({onClick:e,model:t,children:r})=>Be.default.createElement("li",null,Be.default.createElement(oa.Link,{onClick:n=>{t.setError(void 0),n.preventDefault(),e()},href:"#"},Be.default.createElement(oa.Typography,{display:"inline"},r))),V2=(0,Em.observer)(function({model:e}){return Be.default.createElement("ul",null,Be.default.createElement(Gt,{model:e,onClick:()=>Ot(e,void 0,{uri:"https://jbrowse.org/genomes/newick_trees/sarscov2phylo.pub.ft.nh",locationType:"UriLocation"})},"230k COVID-19 samples (tree only)"),Be.default.createElement(Gt,{model:e,onClick:()=>{e.setData({msa:ym,tree:Sm})}},"Small protein MSA+tree"),Be.default.createElement(Gt,{model:e,onClick:()=>{e.setData({msa:wm})}},"Small MSA only"),Be.default.createElement(Gt,{model:e,onClick:()=>Ot(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/pfam-cov2.stock",locationType:"UriLocation"})},"PFAM SARS-CoV2 multi-stockholm"),Be.default.createElement(Gt,{model:e,onClick:()=>Ot(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/Lysine.stock",locationType:"UriLocation"})},"Lysine stockholm file"),Be.default.createElement(Gt,{model:e,onClick:()=>Ot(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/PF01601_full.txt",locationType:"UriLocation"})},"PF01601 stockholm file (SARS-CoV2 spike protein)"),Be.default.createElement(Gt,{model:e,onClick:()=>Ot(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/europe_covid.fa",locationType:"UriLocation"})},"Europe COVID full genomes (LR883044.1 and 199 other sequences)"),Be.default.createElement(Gt,{model:e,onClick:()=>Ot(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/rhv_test-only.aligned_with_mafft_auto.fa",locationType:"UriLocation"},{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/rhv_test-only.aligned_with_mafft_auto.nh",locationType:"UriLocation"})},"MAFFT+VeryFastTree(17.9k samples)"),Be.default.createElement(Gt,{model:e,onClick:()=>Ot(e,{uri:"https://jbrowse.org/demos/ttc39a.mfa",locationType:"UriLocation"})},"Human BLAST results mfa"))}),Om=V2});var ce,Am,ke,nf,Pm,qm=C(()=>{ce=x(I()),Am=x(D()),ke=x(N()),nf=x(qe());rf();Mm();Pm=(0,Am.observer)(({model:e})=>{let[t,r]=(0,ce.useState)(),[n,i]=(0,ce.useState)(),{error:o}=e;return ce.default.createElement(ke.Container,null,ce.default.createElement("div",{style:{width:"50%"}},o?ce.default.createElement("div",{style:{padding:20}},ce.default.createElement(ke.Typography,{color:"error"},"Error: ",`${o}`)):null,ce.default.createElement(ke.Typography,null,"Open an MSA file (stockholm or clustal format) and/or a tree file (newick format)."),ce.default.createElement(ke.Typography,{color:"error"},"Note: you can open up just an MSA or just a tree, both are not required. 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r=e.max_chain_length,n=e.strstart,i,o,a=e.prev_length,u=e.nice_match,f=e.strstart>e.w_size-Vt?e.strstart-(e.w_size-Vt):0,l=e.window,d=e.w_mask,s=e.prev,c=e.strstart+zr,p=l[n+a-1],m=l[n+a];e.prev_length>=e.good_match&&(r>>=2),u>e.lookahead&&(u=e.lookahead);do if(i=t,!(l[i+a]!==m||l[i+a-1]!==p||l[i]!==l[n]||l[++i]!==l[n+1])){n+=2,i++;do;while(l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&n<c);if(o=zr-(c-n),n=c-zr,o>a){if(e.match_start=t,a=o,o>=u)break;p=l[n+a-1],m=l[n+a]}}while((t=s[t&d])>f&&--r!==0);return a<=e.lookahead?a:e.lookahead},xi=e=>{let t=e.w_size,r,n,i;do{if(n=e.window_size-e.lookahead-e.strstart,e.strstart>=t+(t-Vt)&&(e.window.set(e.window.subarray(t,t+t-n),0),e.match_start-=t,e.strstart-=t,e.block_start-=t,e.insert>e.strstart&&(e.insert=e.strstart),yW(e),n+=t),e.strm.avail_in===0)break;if(r=Hh(e.strm,e.window,e.strstart+e.lookahead,n),e.lookahead+=r,e.lookahead+e.insert>=V)for(i=e.strstart-e.insert,e.ins_h=e.window[i],e.ins_h=Ur(e,e.ins_h,e.window[i+1]);e.insert&&(e.ins_h=Ur(e,e.ins_h,e.window[i+V-1]),e.prev[i&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=i,i++,e.insert--,!(e.lookahead+e.insert<V)););}while(e.lookahead<Vt&&e.strm.avail_in!==0)},WM=(e,t)=>{let r=e.pending_buf_size-5>e.w_size?e.w_size:e.pending_buf_size-5,n,i,o,a=0,u=e.strm.avail_in;do{if(n=65535,o=e.bi_valid+42>>3,e.strm.avail_out<o||(o=e.strm.avail_out-o,i=e.strstart-e.block_start,n>i+e.strm.avail_in&&(n=i+e.strm.avail_in),n>o&&(n=o),n<r&&(n===0&&t!==dt||t===Vr||n!==i+e.strm.avail_in)))break;a=t===dt&&n===i+e.strm.avail_in?1:0,Lh(e,0,0,a),e.pending_buf[e.pending-4]=n,e.pending_buf[e.pending-3]=n>>8,e.pending_buf[e.pending-2]=~n,e.pending_buf[e.pending-1]=~n>>8,it(e.strm),i&&(i>n&&(i=n),e.strm.output.set(e.window.subarray(e.block_start,e.block_start+i),e.strm.next_out),e.strm.next_out+=i,e.strm.avail_out-=i,e.strm.total_out+=i,e.block_start+=i,n-=i),n&&(Hh(e.strm,e.strm.output,e.strm.next_out,n),e.strm.next_out+=n,e.strm.avail_out-=n,e.strm.total_out+=n)}while(a===0);return 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r,n;for(;;){if(e.lookahead<Vt){if(xi(e),e.lookahead<Vt&&t===Vr)return De;if(e.lookahead===0)break}if(r=0,e.lookahead>=V&&(e.ins_h=Ur(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),r!==0&&e.strstart-r<=e.w_size-Vt&&(e.match_length=UM(e,r)),e.match_length>=V)if(n=Hr(e,e.strstart-e.match_start,e.match_length-V),e.lookahead-=e.match_length,e.match_length<=e.max_lazy_match&&e.lookahead>=V){e.match_length--;do e.strstart++,e.ins_h=Ur(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart;while(--e.match_length!==0);e.strstart++}else e.strstart+=e.match_length,e.match_length=0,e.ins_h=e.window[e.strstart],e.ins_h=Ur(e,e.ins_h,e.window[e.strstart+1]);else n=Hr(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++;if(n&&(ot(e,!1),e.strm.avail_out===0))return De}return e.insert=e.strstart<V-1?e.strstart:V-1,t===dt?(ot(e,!0),e.strm.avail_out===0?bn:Ai):e.sym_next&&(ot(e,!1),e.strm.avail_out===0)?De:Mi},gi=(e,t)=>{let r,n,i;for(;;){if(e.lookahead<Vt){if(xi(e),e.lookahead<Vt&&t===Vr)return De;if(e.lookahead===0)break}if(r=0,e.lookahead>=V&&(e.ins_h=Ur(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),e.prev_length=e.match_length,e.prev_match=e.match_start,e.match_length=V-1,r!==0&&e.prev_length<e.max_lazy_match&&e.strstart-r<=e.w_size-Vt&&(e.match_length=UM(e,r),e.match_length<=5&&(e.strategy===iW||e.match_length===V&&e.strstart-e.match_start>4096)&&(e.match_length=V-1)),e.prev_length>=V&&e.match_length<=e.prev_length){i=e.strstart+e.lookahead-V,n=Hr(e,e.strstart-1-e.prev_match,e.prev_length-V),e.lookahead-=e.prev_length-1,e.prev_length-=2;do++e.strstart<=i&&(e.ins_h=Ur(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart);while(--e.prev_length!==0);if(e.match_available=0,e.match_length=V-1,e.strstart++,n&&(ot(e,!1),e.strm.avail_out===0))return De}else if(e.match_available){if(n=Hr(e,0,e.window[e.strstart-1]),n&&ot(e,!1),e.strstart++,e.lookahead--,e.strm.avail_out===0)return De}else e.match_available=1,e.strstart++,e.lookahead--}return e.match_available&&(n=Hr(e,0,e.window[e.strstart-1]),e.match_available=0),e.insert=e.strstart<V-1?e.strstart:V-1,t===dt?(ot(e,!0),e.strm.avail_out===0?bn:Ai):e.sym_next&&(ot(e,!1),e.strm.avail_out===0)?De:Mi},SW=(e,t)=>{let r,n,i,o,a=e.window;for(;;){if(e.lookahead<=zr){if(xi(e),e.lookahead<=zr&&t===Vr)return De;if(e.lookahead===0)break}if(e.match_length=0,e.lookahead>=V&&e.strstart>0&&(i=e.strstart-1,n=a[i],n===a[++i]&&n===a[++i]&&n===a[++i])){o=e.strstart+zr;do;while(n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&i<o);e.match_length=zr-(o-i),e.match_length>e.lookahead&&(e.match_length=e.lookahead)}if(e.match_length>=V?(r=Hr(e,1,e.match_length-V),e.lookahead-=e.match_length,e.strstart+=e.match_length,e.match_length=0):(r=Hr(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++),r&&(ot(e,!1),e.strm.avail_out===0))return De}return e.insert=0,t===dt?(ot(e,!0),e.strm.avail_out===0?bn:Ai):e.sym_next&&(ot(e,!1),e.strm.avail_out===0)?De:Mi},xW=(e,t)=>{let r;for(;;){if(e.lookahead===0&&(xi(e),e.lookahead===0)){if(t===Vr)return De;break}if(e.match_length=0,r=Hr(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++,r&&(ot(e,!1),e.strm.avail_out===0))return De}return e.insert=0,t===dt?(ot(e,!0),e.strm.avail_out===0?bn:Ai):e.sym_next&&(ot(e,!1),e.strm.avail_out===0)?De:Mi};function Bt(e,t,r,n,i){this.good_length=e,this.max_lazy=t,this.nice_length=r,this.max_chain=n,this.func=i}var Do=[new Bt(0,0,0,0,WM),new Bt(4,4,8,4,Oh),new Bt(4,5,16,8,Oh),new Bt(4,6,32,32,Oh),new Bt(4,4,16,16,gi),new Bt(8,16,32,32,gi),new Bt(8,16,128,128,gi),new Bt(8,32,128,256,gi),new Bt(32,128,258,1024,gi),new Bt(32,258,258,4096,gi)],EW=e=>{e.window_size=2*e.w_size,Br(e.head),e.max_lazy_match=Do[e.level].max_lazy,e.good_match=Do[e.level].good_length,e.nice_match=Do[e.level].nice_length,e.max_chain_length=Do[e.level].max_chain,e.strstart=0,e.block_start=0,e.lookahead=0,e.insert=0,e.match_length=e.prev_length=V-1,e.match_available=0,e.ins_h=0};function OW(){this.strm=null,this.status=0,this.pending_buf=null,this.pending_buf_size=0,this.pending_out=0,this.pending=0,this.wrap=0,this.gzhead=null,this.gzindex=0,this.method=Gc,this.last_flush=-1,this.w_size=0,this.w_bits=0,this.w_mask=0,this.window=null,this.window_size=0,this.prev=null,this.head=null,this.ins_h=0,this.hash_size=0,this.hash_bits=0,this.hash_mask=0,this.hash_shift=0,this.block_start=0,this.match_length=0,this.prev_match=0,this.match_available=0,this.strstart=0,this.match_start=0,this.lookahead=0,this.prev_length=0,this.max_chain_length=0,this.max_lazy_match=0,this.level=0,this.strategy=0,this.good_match=0,this.nice_match=0,this.dyn_ltree=new Uint16Array(vW*2),this.dyn_dtree=new Uint16Array((2*hW+1)*2),this.bl_tree=new Uint16Array((2*mW+1)*2),Br(this.dyn_ltree),Br(this.dyn_dtree),Br(this.bl_tree),this.l_desc=null,this.d_desc=null,this.bl_desc=null,this.bl_count=new Uint16Array(_W+1),this.heap=new Uint16Array(2*Fh+1),Br(this.heap),this.heap_len=0,this.heap_max=0,this.depth=new Uint16Array(2*Fh+1),Br(this.depth),this.sym_buf=0,this.lit_bufsize=0,this.sym_next=0,this.sym_end=0,this.opt_len=0,this.static_len=0,this.matches=0,this.insert=0,this.bi_buf=0,this.bi_valid=0}var Ko=e=>{if(!e)return 1;let t=e.state;return!t||t.strm!==e||t.status!==Si&&t.status!==$h&&t.status!==Dh&&t.status!==Nh&&t.status!==Bh&&t.status!==zh&&t.status!==mn&&t.status!==Fo?1:0},GM=e=>{if(Ko(e))return vn(e,Ht);e.total_in=e.total_out=0,e.data_type=sW;let t=e.state;return t.pending=0,t.pending_out=0,t.wrap<0&&(t.wrap=-t.wrap),t.status=t.wrap===2?$h:t.wrap?Si:mn,e.adler=t.wrap===2?0:1,t.last_flush=-2,KU(t),Pe},$M=e=>{let t=GM(e);return t===Pe&&EW(e.state),t},MW=(e,t)=>Ko(e)||e.state.wrap!==2?Ht:(e.state.gzhead=t,Pe),YM=(e,t,r,n,i,o)=>{if(!e)return Ht;let a=1;if(t===nW&&(t=6),n<0?(a=0,n=-n):n>15&&(a=2,n-=16),i<1||i>lW||r!==Gc||n<8||n>15||t<0||t>9||o<0||o>aW||n===8&&a!==1)return vn(e,Ht);n===8&&(n=9);let u=new OW;return e.state=u,u.strm=e,u.status=Si,u.wrap=a,u.gzhead=null,u.w_bits=n,u.w_size=1<<u.w_bits,u.w_mask=u.w_size-1,u.hash_bits=i+7,u.hash_size=1<<u.hash_bits,u.hash_mask=u.hash_size-1,u.hash_shift=~~((u.hash_bits+V-1)/V),u.window=new Uint8Array(u.w_size*2),u.head=new Uint16Array(u.hash_size),u.prev=new Uint16Array(u.w_size),u.lit_bufsize=1<<i+6,u.pending_buf_size=u.lit_bufsize*4,u.pending_buf=new Uint8Array(u.pending_buf_size),u.sym_buf=u.lit_bufsize,u.sym_end=(u.lit_bufsize-1)*3,u.level=t,u.strategy=o,u.method=r,$M(e)},AW=(e,t)=>YM(e,t,Gc,cW,fW,uW),PW=(e,t)=>{if(Ko(e)||t>ZO||t<0)return e?vn(e,Ht):Ht;let r=e.state;if(!e.output||e.avail_in!==0&&!e.input||r.status===Fo&&t!==dt)return vn(e,e.avail_out===0?Eh:Ht);let n=r.last_flush;if(r.last_flush=t,r.pending!==0){if(it(e),e.avail_out===0)return r.last_flush=-1,Pe}else if(e.avail_in===0&&JO(t)<=JO(n)&&t!==dt)return vn(e,Eh);if(r.status===Fo&&e.avail_in!==0)return vn(e,Eh);if(r.status===Si&&r.wrap===0&&(r.status=mn),r.status===Si){let 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t.wsize=0,t.whave=0,t.wnext=0,i2(e)},a2=(e,t)=>{let r;if(yn(e))return pt;let n=e.state;return t<0?(r=0,t=-t):(r=(t>>4)+5,t<48&&(t&=15)),t&&(t<8||t>15)?pt:(n.window!==null&&n.wbits!==t&&(n.window=null),n.wrap=r,n.wbits=t,o2(e))},u2=(e,t)=>{if(!e)return pt;let r=new MG;e.state=r,r.strm=e,r.window=null,r.mode=Yc;let n=a2(e,t);return n!==gn&&(e.state=null),n},AG=e=>u2(e,OG),AM=!0,kh,Th,PG=e=>{if(AM){kh=new Int32Array(512),Th=new Int32Array(32);let t=0;for(;t<144;)e.lens[t++]=8;for(;t<256;)e.lens[t++]=9;for(;t<280;)e.lens[t++]=7;for(;t<288;)e.lens[t++]=8;for(zo(JM,e.lens,0,288,kh,0,e.work,{bits:9}),t=0;t<32;)e.lens[t++]=5;zo(QM,e.lens,0,32,Th,0,e.work,{bits:5}),AM=!1}e.lencode=kh,e.lenbits=9,e.distcode=Th,e.distbits=5},s2=(e,t,r,n)=>{let i,o=e.state;return o.window===null&&(o.wsize=1<<o.wbits,o.wnext=0,o.whave=0,o.window=new Uint8Array(o.wsize)),n>=o.wsize?(o.window.set(t.subarray(r-o.wsize,r),0),o.wnext=0,o.whave=o.wsize):(i=o.wsize-o.wnext,i>n&&(i=n),o.window.set(t.subarray(r-n,r-n+i),o.wnext),n-=i,n?(o.window.set(t.subarray(r-n,r),0),o.wnext=n,o.whave=o.wsize):(o.wnext+=i,o.wnext===o.wsize&&(o.wnext=0),o.whave<o.wsize&&(o.whave+=i))),0},qG=(e,t)=>{let r,n,i,o,a,u,f,l,d,s,c,p,m,v,h=0,_,y,w,S,E,O,A,q,M=new Uint8Array(4),P,k,R=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]);if(yn(e)||!e.output||!e.input&&e.avail_in!==0)return pt;r=e.state,r.mode===sr&&(r.mode=Ah),a=e.next_out,i=e.output,f=e.avail_out,o=e.next_in,n=e.input,u=e.avail_in,l=r.hold,d=r.bits,s=u,c=f,q=gn;e:for(;;)switch(r.mode){case Yc:if(r.wrap===0){r.mode=Ah;break}for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&2&&l===35615){r.wbits===0&&(r.wbits=15),r.check=0,M[0]=l&255,M[1]=l>>>8&255,r.check=we(r.check,M,2,0),l=0,d=0,r.mode=oM;break}if(r.head&&(r.head.done=!1),!(r.wrap&1)||(((l&255)<<8)+(l>>8))%31){e.msg="incorrect header check",r.mode=ne;break}if((l&15)!==iM){e.msg="unknown compression method",r.mode=ne;break}if(l>>>=4,d-=4,A=(l&15)+8,r.wbits===0&&(r.wbits=A),A>15||A>r.wbits){e.msg="invalid window size",r.mode=ne;break}r.dmax=1<<r.wbits,r.flags=0,e.adler=r.check=1,r.mode=l&512?pM:sr,l=0,d=0;break;case oM:for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.flags=l,(r.flags&255)!==iM){e.msg="unknown compression method",r.mode=ne;break}if(r.flags&57344){e.msg="unknown header flags set",r.mode=ne;break}r.head&&(r.head.text=l>>8&1),r.flags&512&&r.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,r.check=we(r.check,M,2,0)),l=0,d=0,r.mode=aM;case aM:for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.head&&(r.head.time=l),r.flags&512&&r.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,M[2]=l>>>16&255,M[3]=l>>>24&255,r.check=we(r.check,M,4,0)),l=0,d=0,r.mode=uM;case uM:for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.head&&(r.head.xflags=l&255,r.head.os=l>>8),r.flags&512&&r.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,r.check=we(r.check,M,2,0)),l=0,d=0,r.mode=sM;case sM:if(r.flags&1024){for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.length=l,r.head&&(r.head.extra_len=l),r.flags&512&&r.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,r.check=we(r.check,M,2,0)),l=0,d=0}else r.head&&(r.head.extra=null);r.mode=lM;case lM:if(r.flags&1024&&(p=r.length,p>u&&(p=u),p&&(r.head&&(A=r.head.extra_len-r.length,r.head.extra||(r.head.extra=new Uint8Array(r.head.extra_len)),r.head.extra.set(n.subarray(o,o+p),A)),r.flags&512&&r.wrap&4&&(r.check=we(r.check,n,p,o)),u-=p,o+=p,r.length-=p),r.length))break e;r.length=0,r.mode=cM;case cM:if(r.flags&2048){if(u===0)break e;p=0;do A=n[o+p++],r.head&&A&&r.length<65536&&(r.head.name+=String.fromCharCode(A));while(A&&p<u);if(r.flags&512&&r.wrap&4&&(r.check=we(r.check,n,p,o)),u-=p,o+=p,A)break e}else r.head&&(r.head.name=null);r.length=0,r.mode=fM;case fM:if(r.flags&4096){if(u===0)break e;p=0;do A=n[o+p++],r.head&&A&&r.length<65536&&(r.head.comment+=String.fromCharCode(A));while(A&&p<u);if(r.flags&512&&r.wrap&4&&(r.check=we(r.check,n,p,o)),u-=p,o+=p,A)break e}else r.head&&(r.head.comment=null);r.mode=dM;case dM:if(r.flags&512){for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&4&&l!==(r.check&65535)){e.msg="header crc mismatch",r.mode=ne;break}l=0,d=0}r.head&&(r.head.hcrc=r.flags>>9&1,r.head.done=!0),e.adler=r.check=0,r.mode=sr;break;case pM:for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}e.adler=r.check=MM(l),l=0,d=0,r.mode=Wc;case Wc:if(r.havedict===0)return e.next_out=a,e.avail_out=f,e.next_in=o,e.avail_in=u,r.hold=l,r.bits=d,yG;e.adler=r.check=1,r.mode=sr;case sr:if(t===bG||t===Nc)break e;case Ah:if(r.last){l>>>=d&7,d-=d&7,r.mode=qh;break}for(;d<3;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}switch(r.last=l&1,l>>>=1,d-=1,l&3){case 0:r.mode=hM;break;case 1:if(PG(r),r.mode=Bc,t===Nc){l>>>=2,d-=2;break e}break;case 2:r.mode=vM;break;case 3:e.msg="invalid block type",r.mode=ne}l>>>=2,d-=2;break;case hM:for(l>>>=d&7,d-=d&7;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if((l&65535)!==(l>>>16^65535)){e.msg="invalid stored block lengths",r.mode=ne;break}if(r.length=l&65535,l=0,d=0,r.mode=Ph,t===Nc)break e;case Ph:r.mode=mM;case mM:if(p=r.length,p){if(p>u&&(p=u),p>f&&(p=f),p===0)break e;i.set(n.subarray(o,o+p),a),u-=p,o+=p,f-=p,a+=p,r.length-=p;break}r.mode=sr;break;case vM:for(;d<14;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.nlen=(l&31)+257,l>>>=5,d-=5,r.ndist=(l&31)+1,l>>>=5,d-=5,r.ncode=(l&15)+4,l>>>=4,d-=4,r.nlen>286||r.ndist>30){e.msg="too many length or distance symbols",r.mode=ne;break}r.have=0,r.mode=_M;case _M:for(;r.have<r.ncode;){for(;d<3;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.lens[R[r.have++]]=l&7,l>>>=3,d-=3}for(;r.have<19;)r.lens[R[r.have++]]=0;if(r.lencode=r.lendyn,r.lenbits=7,P={bits:r.lenbits},q=zo(_G,r.lens,0,19,r.lencode,0,r.work,P),r.lenbits=P.bits,q){e.msg="invalid code lengths set",r.mode=ne;break}r.have=0,r.mode=bM;case bM:for(;r.have<r.nlen+r.ndist;){for(;h=r.lencode[l&(1<<r.lenbits)-1],_=h>>>24,y=h>>>16&255,w=h&65535,!(_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(w<16)l>>>=_,d-=_,r.lens[r.have++]=w;else{if(w===16){for(k=_+2;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(l>>>=_,d-=_,r.have===0){e.msg="invalid bit length repeat",r.mode=ne;break}A=r.lens[r.have-1],p=3+(l&3),l>>>=2,d-=2}else if(w===17){for(k=_+3;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=_,d-=_,A=0,p=3+(l&7),l>>>=3,d-=3}else{for(k=_+7;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=_,d-=_,A=0,p=11+(l&127),l>>>=7,d-=7}if(r.have+p>r.nlen+r.ndist){e.msg="invalid bit length repeat",r.mode=ne;break}for(;p--;)r.lens[r.have++]=A}}if(r.mode===ne)break;if(r.lens[256]===0){e.msg="invalid code -- missing end-of-block",r.mode=ne;break}if(r.lenbits=9,P={bits:r.lenbits},q=zo(JM,r.lens,0,r.nlen,r.lencode,0,r.work,P),r.lenbits=P.bits,q){e.msg="invalid literal/lengths set",r.mode=ne;break}if(r.distbits=6,r.distcode=r.distdyn,P={bits:r.distbits},q=zo(QM,r.lens,r.nlen,r.ndist,r.distcode,0,r.work,P),r.distbits=P.bits,q){e.msg="invalid distances set",r.mode=ne;break}if(r.mode=Bc,t===Nc)break e;case Bc:r.mode=zc;case zc:if(u>=6&&f>=258){e.next_out=a,e.avail_out=f,e.next_in=o,e.avail_in=u,r.hold=l,r.bits=d,fG(e,c),a=e.next_out,i=e.output,f=e.avail_out,o=e.next_in,n=e.input,u=e.avail_in,l=r.hold,d=r.bits,r.mode===sr&&(r.back=-1);break}for(r.back=0;h=r.lencode[l&(1<<r.lenbits)-1],_=h>>>24,y=h>>>16&255,w=h&65535,!(_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(y&&!(y&240)){for(S=_,E=y,O=w;h=r.lencode[O+((l&(1<<S+E)-1)>>S)],_=h>>>24,y=h>>>16&255,w=h&65535,!(S+_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=S,d-=S,r.back+=S}if(l>>>=_,d-=_,r.back+=_,r.length=w,y===0){r.mode=xM;break}if(y&32){r.back=-1,r.mode=sr;break}if(y&64){e.msg="invalid literal/length code",r.mode=ne;break}r.extra=y&15,r.mode=gM;case gM:if(r.extra){for(k=r.extra;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.length+=l&(1<<r.extra)-1,l>>>=r.extra,d-=r.extra,r.back+=r.extra}r.was=r.length,r.mode=yM;case yM:for(;h=r.distcode[l&(1<<r.distbits)-1],_=h>>>24,y=h>>>16&255,w=h&65535,!(_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(!(y&240)){for(S=_,E=y,O=w;h=r.distcode[O+((l&(1<<S+E)-1)>>S)],_=h>>>24,y=h>>>16&255,w=h&65535,!(S+_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=S,d-=S,r.back+=S}if(l>>>=_,d-=_,r.back+=_,y&64){e.msg="invalid distance code",r.mode=ne;break}r.offset=w,r.extra=y&15,r.mode=wM;case wM:if(r.extra){for(k=r.extra;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.offset+=l&(1<<r.extra)-1,l>>>=r.extra,d-=r.extra,r.back+=r.extra}if(r.offset>r.dmax){e.msg="invalid distance too far back",r.mode=ne;break}r.mode=SM;case SM:if(f===0)break e;if(p=c-f,r.offset>p){if(p=r.offset-p,p>r.whave&&r.sane){e.msg="invalid distance too far back",r.mode=ne;break}p>r.wnext?(p-=r.wnext,m=r.wsize-p):m=r.wnext-p,p>r.length&&(p=r.length),v=r.window}else v=i,m=a-r.offset,p=r.length;p>f&&(p=f),f-=p,r.length-=p;do i[a++]=v[m++];while(--p);r.length===0&&(r.mode=zc);break;case xM:if(f===0)break e;i[a++]=r.length,f--,r.mode=zc;break;case qh:if(r.wrap){for(;d<32;){if(u===0)break e;u--,l|=n[o++]<<d,d+=8}if(c-=f,e.total_out+=c,r.total+=c,r.wrap&4&&c&&(e.adler=r.check=r.flags?we(r.check,i,c,a-c):Go(r.check,i,c,a-c)),c=f,r.wrap&4&&(r.flags?l:MM(l))!==r.check){e.msg="incorrect data check",r.mode=ne;break}l=0,d=0}r.mode=EM;case EM:if(r.wrap&&r.flags){for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&4&&l!==(r.total&4294967295)){e.msg="incorrect length check",r.mode=ne;break}l=0,d=0}r.mode=OM;case OM:q=gG;break e;case ne:q=e2;break e;case r2:return t2;case n2:default:return pt}return e.next_out=a,e.avail_out=f,e.next_in=o,e.avail_in=u,r.hold=l,r.bits=d,(r.wsize||c!==e.avail_out&&r.mode<ne&&(r.mode<qh||t!==nM))&&s2(e,e.output,e.next_out,c-e.avail_out),s-=e.avail_in,c-=e.avail_out,e.total_in+=s,e.total_out+=c,r.total+=c,r.wrap&4&&c&&(e.adler=r.check=r.flags?we(r.check,i,c,e.next_out-c):Go(r.check,i,c,e.next_out-c)),e.data_type=r.bits+(r.last?64:0)+(r.mode===sr?128:0)+(r.mode===Bc||r.mode===Ph?256:0),(s===0&&c===0||t===nM)&&q===gn&&(q=wG),q},kG=e=>{if(yn(e))return pt;let t=e.state;return t.window&&(t.window=null),e.state=null,gn},TG=(e,t)=>{if(yn(e))return pt;let r=e.state;return r.wrap&2?(r.head=t,t.done=!1,gn):pt},CG=(e,t)=>{let r=t.length,n,i,o;return yn(e)||(n=e.state,n.wrap!==0&&n.mode!==Wc)?pt:n.mode===Wc&&(i=1,i=Go(i,t,r,0),i!==n.check)?e2:(o=s2(e,t,r,r),o?(n.mode=r2,t2):(n.havedict=1,gn))},jG=o2,IG=a2,RG=i2,LG=AG,FG=u2,DG=qG,NG=kG,BG=TG,zG=CG,HG="pako inflate (from Nodeca project)",cr={inflateReset:jG,inflateReset2:IG,inflateResetKeep:RG,inflateInit:LG,inflateInit2:FG,inflate:DG,inflateEnd:NG,inflateGetHeader:BG,inflateSetDictionary:zG,inflateInfo:HG};function VG(){this.text=0,this.time=0,this.xflags=0,this.os=0,this.extra=null,this.extra_len=0,this.name="",this.comment="",this.hcrc=0,this.done=!1}var UG=VG,l2=Object.prototype.toString,{Z_NO_FLUSH:WG,Z_FINISH:GG,Z_OK:Xo,Z_STREAM_END:Ch,Z_NEED_DICT:jh,Z_STREAM_ERROR:$G,Z_DATA_ERROR:PM,Z_MEM_ERROR:YG}=Oi;function Qo(e){this.options=$c.assign({chunkSize:1024*64,windowBits:15,to:""},e||{});let 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r>>>1},P$=e=>{e.bi_valid===16?(sa(e,e.bi_buf),e.bi_buf=0,e.bi_valid=0):e.bi_valid>=8&&(e.pending_buf[e.pending++]=e.bi_buf&255,e.bi_buf>>=8,e.bi_valid-=8)},q$=(e,t)=>{let r=t.dyn_tree,n=t.max_code,i=t.stat_desc.static_tree,o=t.stat_desc.has_stree,a=t.stat_desc.extra_bits,u=t.stat_desc.extra_base,d=t.stat_desc.max_length,l,f,s,c,p,m,v=0;for(c=0;c<=qn;c++)e.bl_count[c]=0;for(r[e.heap[e.heap_max]*2+1]=0,l=e.heap_max+1;l<PM;l++)f=e.heap[l],c=r[r[f*2+1]*2+1]+1,c>d&&(c=d,v++),r[f*2+1]=c,!(f>n)&&(e.bl_count[c]++,p=0,f>=u&&(p=a[f-u]),m=r[f*2],e.opt_len+=m*(c+p),o&&(e.static_len+=m*(i[f*2+1]+p)));if(v!==0){do{for(c=d-1;e.bl_count[c]===0;)c--;e.bl_count[c]--,e.bl_count[c+1]+=2,e.bl_count[d]--,v-=2}while(v>0);for(c=d;c!==0;c--)for(f=e.bl_count[c];f!==0;)s=e.heap[--l],!(s>n)&&(r[s*2+1]!==c&&(e.opt_len+=(c-r[s*2+1])*r[s*2],r[s*2+1]=c),f--)}},DM=(e,t,r)=>{let n=new Array(qn+1),i=0,o,a;for(o=1;o<=qn;o++)i=i+r[o-1]<<1,n[o]=i;for(a=0;a<=t;a++){let u=e[a*2+1];u!==0&&(e[a*2]=LM(n[u]++,u))}},T$=()=>{let e,t,r,n,i,o=new Array(qn+1);for(r=0,n=0;n<bm-1;n++)for(wm[n]=r,e=0;e<1<<lm[n];e++)ua[r++]=n;for(ua[r-1]=n,i=0,n=0;n<16;n++)for(uf[n]=i,e=0;e<1<<af[n];e++)aa[i++]=n;for(i>>=7;n<Di;n++)for(uf[n]=i<<7,e=0;e<1<<af[n]-7;e++)aa[256+i++]=n;for(t=0;t<=qn;t++)o[t]=0;for(e=0;e<=143;)br[e*2+1]=8,e++,o[8]++;for(;e<=255;)br[e*2+1]=9,e++,o[9]++;for(;e<=279;)br[e*2+1]=7,e++,o[7]++;for(;e<=287;)br[e*2+1]=8,e++,o[8]++;for(DM(br,oa+1,o),e=0;e<Di;e++)ra[e*2+1]=5,ra[e*2]=LM(e,5);jM=new Zh(br,lm,pa+1,oa,qn),IM=new Zh(ra,af,0,Di,qn),RM=new Zh(new Array(0),M$,0,gm,O$)},NM=e=>{let t;for(t=0;t<oa;t++)e.dyn_ltree[t*2]=0;for(t=0;t<Di;t++)e.dyn_dtree[t*2]=0;for(t=0;t<gm;t++)e.bl_tree[t*2]=0;e.dyn_ltree[ym*2]=1,e.opt_len=e.static_len=0,e.sym_next=e.matches=0},BM=e=>{e.bi_valid>8?sa(e,e.bi_buf):e.bi_valid>0&&(e.pending_buf[e.pending++]=e.bi_buf),e.bi_buf=0,e.bi_valid=0},VO=(e,t,r,n)=>{let i=t*2,o=r*2;return e[i]<e[o]||e[i]===e[o]&&n[t]<=n[r]},Jh=(e,t,r)=>{let n=e.heap[r],i=r<<1;for(;i<=e.heap_len&&(i<e.heap_len&&VO(t,e.heap[i+1],e.heap[i],e.depth)&&i++,!VO(t,n,e.heap[i],e.depth));)e.heap[r]=e.heap[i],r=i,i<<=1;e.heap[r]=n},WO=(e,t,r)=>{let n,i,o=0,a,u;if(e.sym_next!==0)do n=e.pending_buf[e.sym_buf+o++]&255,n+=(e.pending_buf[e.sym_buf+o++]&255)<<8,i=e.pending_buf[e.sym_buf+o++],n===0?Kt(e,i,t):(a=ua[i],Kt(e,a+pa+1,t),u=lm[a],u!==0&&(i-=wm[a],et(e,i,u)),n--,a=FM(n),Kt(e,a,r),u=af[a],u!==0&&(n-=uf[a],et(e,n,u)));while(o<e.sym_next);Kt(e,ym,t)},cm=(e,t)=>{let r=t.dyn_tree,n=t.stat_desc.static_tree,i=t.stat_desc.has_stree,o=t.stat_desc.elems,a,u,d=-1,l;for(e.heap_len=0,e.heap_max=PM,a=0;a<o;a++)r[a*2]!==0?(e.heap[++e.heap_len]=d=a,e.depth[a]=0):r[a*2+1]=0;for(;e.heap_len<2;)l=e.heap[++e.heap_len]=d<2?++d:0,r[l*2]=1,e.depth[l]=0,e.opt_len--,i&&(e.static_len-=n[l*2+1]);for(t.max_code=d,a=e.heap_len>>1;a>=1;a--)Jh(e,r,a);l=o;do a=e.heap[1],e.heap[1]=e.heap[e.heap_len--],Jh(e,r,1),u=e.heap[1],e.heap[--e.heap_max]=a,e.heap[--e.heap_max]=u,r[l*2]=r[a*2]+r[u*2],e.depth[l]=(e.depth[a]>=e.depth[u]?e.depth[a]:e.depth[u])+1,r[a*2+1]=r[u*2+1]=l,e.heap[1]=l++,Jh(e,r,1);while(e.heap_len>=2);e.heap[--e.heap_max]=e.heap[1],q$(e,t),DM(r,d,e.bl_count)},UO=(e,t,r)=>{let n,i=-1,o,a=t[0*2+1],u=0,d=7,l=4;for(a===0&&(d=138,l=3),t[(r+1)*2+1]=65535,n=0;n<=r;n++)o=a,a=t[(n+1)*2+1],!(++u<d&&o===a)&&(u<l?e.bl_tree[o*2]+=u:o!==0?(o!==i&&e.bl_tree[o*2]++,e.bl_tree[qM*2]++):u<=10?e.bl_tree[TM*2]++:e.bl_tree[kM*2]++,u=0,i=o,a===0?(d=138,l=3):o===a?(d=6,l=3):(d=7,l=4))},GO=(e,t,r)=>{let n,i=-1,o,a=t[0*2+1],u=0,d=7,l=4;for(a===0&&(d=138,l=3),n=0;n<=r;n++)if(o=a,a=t[(n+1)*2+1],!(++u<d&&o===a)){if(u<l)do Kt(e,o,e.bl_tree);while(--u!==0);else o!==0?(o!==i&&(Kt(e,o,e.bl_tree),u--),Kt(e,qM,e.bl_tree),et(e,u-3,2)):u<=10?(Kt(e,TM,e.bl_tree),et(e,u-3,3)):(Kt(e,kM,e.bl_tree),et(e,u-11,7));u=0,i=o,a===0?(d=138,l=3):o===a?(d=6,l=3):(d=7,l=4)}},k$=e=>{let t;for(UO(e,e.dyn_ltree,e.l_desc.max_code),UO(e,e.dyn_dtree,e.d_desc.max_code),cm(e,e.bl_desc),t=gm-1;t>=3&&e.bl_tree[CM[t]*2+1]===0;t--);return e.opt_len+=3*(t+1)+5+5+4,t},C$=(e,t,r,n)=>{let i;for(et(e,t-257,5),et(e,r-1,5),et(e,n-4,4),i=0;i<n;i++)et(e,e.bl_tree[CM[i]*2+1],3);GO(e,e.dyn_ltree,t-1),GO(e,e.dyn_dtree,r-1)},j$=e=>{let t=4093624447,r;for(r=0;r<=31;r++,t>>>=1)if(t&1&&e.dyn_ltree[r*2]!==0)return 0;if(e.dyn_ltree[9*2]!==0||e.dyn_ltree[10*2]!==0||e.dyn_ltree[13*2]!==0)return 1;for(r=32;r<pa;r++)if(e.dyn_ltree[r*2]!==0)return 1;return 0},$O=!1,I$=e=>{$O||(T$(),$O=!0),e.l_desc=new Kh(e.dyn_ltree,jM),e.d_desc=new Kh(e.dyn_dtree,IM),e.bl_desc=new Kh(e.bl_tree,RM),e.bi_buf=0,e.bi_valid=0,NM(e)},zM=(e,t,r,n)=>{et(e,(w$<<1)+(n?1:0),3),BM(e),sa(e,r),sa(e,~r),r&&e.pending_buf.set(e.window.subarray(t,t+r),e.pending),e.pending+=r},R$=e=>{et(e,AM<<1,3),Kt(e,ym,br),P$(e)},F$=(e,t,r,n)=>{let i,o,a=0;e.level>0?(e.strm.data_type===2&&(e.strm.data_type=j$(e)),cm(e,e.l_desc),cm(e,e.d_desc),a=k$(e),i=e.opt_len+3+7>>>3,o=e.static_len+3+7>>>3,o<=i&&(i=o)):i=o=r+5,r+4<=i&&t!==-1?zM(e,t,r,n):e.strategy===4||o===i?(et(e,(AM<<1)+(n?1:0),3),WO(e,br,ra)):(et(e,(S$<<1)+(n?1:0),3),C$(e,e.l_desc.max_code+1,e.d_desc.max_code+1,a+1),WO(e,e.dyn_ltree,e.dyn_dtree)),NM(e),n&&BM(e)},L$=(e,t,r)=>(e.pending_buf[e.sym_buf+e.sym_next++]=t,e.pending_buf[e.sym_buf+e.sym_next++]=t>>8,e.pending_buf[e.sym_buf+e.sym_next++]=r,t===0?e.dyn_ltree[r*2]++:(e.matches++,t--,e.dyn_ltree[(ua[r]+pa+1)*2]++,e.dyn_dtree[FM(t)*2]++),e.sym_next===e.sym_end),D$=I$,N$=zM,B$=F$,z$=L$,H$=R$,V$={_tr_init:D$,_tr_stored_block:N$,_tr_flush_block:B$,_tr_tally:z$,_tr_align:H$},W$=(e,t,r,n)=>{let i=e&65535|0,o=e>>>16&65535|0,a=0;for(;r!==0;){a=r>2e3?2e3:r,r-=a;do i=i+t[n++]|0,o=o+i|0;while(--a);i%=65521,o%=65521}return i|o<<16|0},la=W$,U$=()=>{let e,t=[];for(var r=0;r<256;r++){e=r;for(var n=0;n<8;n++)e=e&1?3988292384^e>>>1:e>>>1;t[r]=e}return t},G$=new Uint32Array(U$()),$$=(e,t,r,n)=>{let i=G$,o=n+r;e^=-1;for(let a=n;a<o;a++)e=e>>>8^i[(e^t[a])&255];return e^-1},Oe=$$,Cn={2:"need dictionary",1:"stream end",0:"","-1":"file error","-2":"stream error","-3":"data error","-4":"insufficient memory","-5":"buffer error","-6":"incompatible version"},Hi={Z_NO_FLUSH:0,Z_PARTIAL_FLUSH:1,Z_SYNC_FLUSH:2,Z_FULL_FLUSH:3,Z_FINISH:4,Z_BLOCK:5,Z_TREES:6,Z_OK:0,Z_STREAM_END:1,Z_NEED_DICT:2,Z_ERRNO:-1,Z_STREAM_ERROR:-2,Z_DATA_ERROR:-3,Z_MEM_ERROR:-4,Z_BUF_ERROR:-5,Z_NO_COMPRESSION:0,Z_BEST_SPEED:1,Z_BEST_COMPRESSION:9,Z_DEFAULT_COMPRESSION:-1,Z_FILTERED:1,Z_HUFFMAN_ONLY:2,Z_RLE:3,Z_FIXED:4,Z_DEFAULT_STRATEGY:0,Z_BINARY:0,Z_TEXT:1,Z_UNKNOWN:2,Z_DEFLATED:8},{_tr_init:Y$,_tr_stored_block:fm,_tr_flush_block:X$,_tr_tally:tn,_tr_align:Z$}=V$,{Z_NO_FLUSH:rn,Z_PARTIAL_FLUSH:K$,Z_FULL_FLUSH:J$,Z_FINISH:gt,Z_BLOCK:YO,Z_OK:Ce,Z_STREAM_END:XO,Z_STREAM_ERROR:Jt,Z_DATA_ERROR:Q$,Z_BUF_ERROR:Qh,Z_DEFAULT_COMPRESSION:eY,Z_FILTERED:tY,Z_HUFFMAN_ONLY:ef,Z_RLE:rY,Z_FIXED:nY,Z_DEFAULT_STRATEGY:iY,Z_UNKNOWN:oY,Z_DEFLATED:cf}=Hi,aY=9,uY=15,sY=8,lY=29,cY=256,dm=cY+1+lY,fY=30,dY=19,pY=2*dm+1,hY=15,U=3,en=258,Qt=en+U+1,mY=32,Ni=42,Sm=57,pm=69,hm=73,mm=91,vm=103,Tn=113,ea=666,Ue=1,Vi=2,jn=3,Wi=4,vY=3,kn=(e,t)=>(e.msg=Cn[t],t),ZO=e=>e*2-(e>4?9:0),Qr=e=>{let t=e.length;for(;--t>=0;)e[t]=0},_Y=e=>{let t,r,n,i=e.w_size;t=e.hash_size,n=t;do r=e.head[--n],e.head[n]=r>=i?r-i:0;while(--t);t=i,n=t;do r=e.prev[--n],e.prev[n]=r>=i?r-i:0;while(--t)},bY=(e,t,r)=>(t<<e.hash_shift^r)&e.hash_mask,nn=bY,st=e=>{let t=e.state,r=t.pending;r>e.avail_out&&(r=e.avail_out),r!==0&&(e.output.set(t.pending_buf.subarray(t.pending_out,t.pending_out+r),e.next_out),e.next_out+=r,t.pending_out+=r,e.total_out+=r,e.avail_out-=r,t.pending-=r,t.pending===0&&(t.pending_out=0))},lt=(e,t)=>{X$(e,e.block_start>=0?e.block_start:-1,e.strstart-e.block_start,t),e.block_start=e.strstart,st(e.strm)},X=(e,t)=>{e.pending_buf[e.pending++]=t},Qo=(e,t)=>{e.pending_buf[e.pending++]=t>>>8&255,e.pending_buf[e.pending++]=t&255},_m=(e,t,r,n)=>{let i=e.avail_in;return i>n&&(i=n),i===0?0:(e.avail_in-=i,t.set(e.input.subarray(e.next_in,e.next_in+i),r),e.state.wrap===1?e.adler=la(e.adler,t,i,r):e.state.wrap===2&&(e.adler=Oe(e.adler,t,i,r)),e.next_in+=i,e.total_in+=i,i)},HM=(e,t)=>{let r=e.max_chain_length,n=e.strstart,i,o,a=e.prev_length,u=e.nice_match,d=e.strstart>e.w_size-Qt?e.strstart-(e.w_size-Qt):0,l=e.window,f=e.w_mask,s=e.prev,c=e.strstart+en,p=l[n+a-1],m=l[n+a];e.prev_length>=e.good_match&&(r>>=2),u>e.lookahead&&(u=e.lookahead);do if(i=t,!(l[i+a]!==m||l[i+a-1]!==p||l[i]!==l[n]||l[++i]!==l[n+1])){n+=2,i++;do;while(l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&n<c);if(o=en-(c-n),n=c-en,o>a){if(e.match_start=t,a=o,o>=u)break;p=l[n+a-1],m=l[n+a]}}while((t=s[t&f])>d&&--r!==0);return a<=e.lookahead?a:e.lookahead},Bi=e=>{let t=e.w_size,r,n,i;do{if(n=e.window_size-e.lookahead-e.strstart,e.strstart>=t+(t-Qt)&&(e.window.set(e.window.subarray(t,t+t-n),0),e.match_start-=t,e.strstart-=t,e.block_start-=t,e.insert>e.strstart&&(e.insert=e.strstart),_Y(e),n+=t),e.strm.avail_in===0)break;if(r=_m(e.strm,e.window,e.strstart+e.lookahead,n),e.lookahead+=r,e.lookahead+e.insert>=U)for(i=e.strstart-e.insert,e.ins_h=e.window[i],e.ins_h=nn(e,e.ins_h,e.window[i+1]);e.insert&&(e.ins_h=nn(e,e.ins_h,e.window[i+U-1]),e.prev[i&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=i,i++,e.insert--,!(e.lookahead+e.insert<U)););}while(e.lookahead<Qt&&e.strm.avail_in!==0)},VM=(e,t)=>{let r=e.pending_buf_size-5>e.w_size?e.w_size:e.pending_buf_size-5,n,i,o,a=0,u=e.strm.avail_in;do{if(n=65535,o=e.bi_valid+42>>3,e.strm.avail_out<o||(o=e.strm.avail_out-o,i=e.strstart-e.block_start,n>i+e.strm.avail_in&&(n=i+e.strm.avail_in),n>o&&(n=o),n<r&&(n===0&&t!==gt||t===rn||n!==i+e.strm.avail_in)))break;a=t===gt&&n===i+e.strm.avail_in?1:0,fm(e,0,0,a),e.pending_buf[e.pending-4]=n,e.pending_buf[e.pending-3]=n>>8,e.pending_buf[e.pending-2]=~n,e.pending_buf[e.pending-1]=~n>>8,st(e.strm),i&&(i>n&&(i=n),e.strm.output.set(e.window.subarray(e.block_start,e.block_start+i),e.strm.next_out),e.strm.next_out+=i,e.strm.avail_out-=i,e.strm.total_out+=i,e.block_start+=i,n-=i),n&&(_m(e.strm,e.strm.output,e.strm.next_out,n),e.strm.next_out+=n,e.strm.avail_out-=n,e.strm.total_out+=n)}while(a===0);return 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e.drawLabels&&e.rowHeight>=5}})).actions(e=>({setDrawMsaLetters(t){e.drawMsaLetters=t},zoomOutHorizontal(){e.colWidth=Math.max(1,Math.floor(e.colWidth*.75)),e.scrollX=Ut(e.maxScrollX,e.scrollX,0)},zoomInHorizontal(){e.colWidth=Math.ceil(e.colWidth*1.5),e.scrollX=Ut(e.maxScrollX,e.scrollX,0)},zoomInVertical(){e.rowHeight=Math.ceil(e.rowHeight*1.5)},zoomOutVertical(){e.rowHeight=Math.max(1.5,Math.floor(e.rowHeight*.75))},zoomIn(){(0,Ct.transaction)(()=>{e.colWidth=Math.ceil(e.colWidth*1.5),e.rowHeight=Math.ceil(e.rowHeight*1.5),e.scrollX=Ut(e.maxScrollX,e.scrollX,0)})},zoomOut(){(0,Ct.transaction)(()=>{e.colWidth=Math.max(1,Math.floor(e.colWidth*.75)),e.rowHeight=Math.max(1.5,Math.floor(e.rowHeight*.75)),e.scrollX=Ut(e.maxScrollX,e.scrollX,0)})},setInterProAnnotations(t){e.interProAnnotations=t},doScrollY(t){e.scrollY=Ut(-e.totalHeight+10,e.scrollY+t,0)},doScrollX(t){e.scrollX=Ut(e.maxScrollX,e.scrollX+t,0)},setScrollX(t){e.scrollX=Ut(e.maxScrollX,t,0)},toggleTrack(t){e.turnedOffTracks.has(t)?e.turnedOffTracks.delete(t):e.turnedOffTracks.set(t,!0)},setStatus(t){e.status=t}})).views(e=>({get 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n.get(t)?.[Cm(i,r)]},mouseOverCoordToGapRemovedRowCoord(t,r){let{rowMap:n,blanks:i}=e,o=n.get(t);if(o!==void 0){let a=Cm(i,r),u=WA(o,a);return o[u]==="-"||!o[u]?void 0:u}else return},seqCoordToRowSpecificGlobalCoord(t,r){let{rowNames:n,rows:i}=e,o=n.indexOf(t);if(o!==-1&&i[o]){let a=i[o][1],u=0,d=0;for(;u<r;d++)if(a[d]!=="-")u++;else if(u>=r)break;return d}return 0}})).views(e=>({get msaAreaHeight(){return e.height-(e.showHorizontalScrollbar?e.minimapHeight:0)-e.headerHeight},get totalTrackAreaHeight(){return(0,Ln.sum)(e.turnedOnTracks.map(t=>t.model.height))},get tidyInterProAnnotationTypes(){let t=new Map;for(let r of this.tidyInterProAnnotations)t.set(r.accession,r);return t},get tidyInterProAnnotations(){let t=[],{interProAnnotations:r}=e;if(r)for(let[n,i]of Object.entries(r))for(let{signature:o,locations:a}of i.matches){let{entry:u}=o;if(u){let{name:d,accession:l,description:f}=u;for(let{start:s,end:c}of a)t.push({id:n,name:d,accession:l,description:f,start:s,end:c})}}return 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d2=g((due,f2)=>{f2.exports=JBrowseExports["@jbrowse/core/pluggableElementTypes"]});async function p2(e,t){let r=await fetch(e,t);if(!r.ok)throw new Error(`HTTP ${r.status} fetching ${e} ${await r.text()}`);return r}async function je(e,t){return(await p2(e,t)).text()}async function h2(e,t){return(await p2(e,t)).json()}function _f(e){return new Promise(t=>setTimeout(t,e))}var Lm=C(()=>{"use strict"});async function v2({query:e,blastDatabase:t,blastProgram:r,onProgress:n,onRid:i}){n("Submitting to NCBI BLAST...");let{rid:o}=await bZ({query:e,blastDatabase:t,blastProgram:r});i(o),await gZ({rid:o,onProgress:n});let a=await h2(`${xa}?CMD=Get&RID=${o}&FORMAT_TYPE=JSON2_S&FORMAT_OBJECT=Alignment`);return{rid:o,hits:a.BlastOutput2[0]?.report.results.search.hits??[]}}async function bZ({query:e,blastProgram:t,blastDatabase:r}){let n=await je(xa,{method:"POST",body:new URLSearchParams({CMD:"Put",PROGRAM:t,DATABASE:r,QUERY:e,...r==="nr_clustered_seq"?{CLUSTERED_DB:"on",DB_TYPE:"Experimental 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strict";Ef=x(R()),Of=x(B());A2();Dm();zm=wZ});function SZ({rid:e,error:t}){return wt.default.createElement("div",null,e?wt.default.createElement(zm,{rid:e}):null,wt.default.createElement(Mf.ErrorMessage,{error:t}))}function xZ({rid:e,progress:t}){let{classes:r}=k2();return wt.default.createElement("div",{className:r.loading},e?wt.default.createElement(zm,{rid:e}):null,wt.default.createElement(Hm.Typography,null,t))}var wt,Hm,q2,T2,Mf,k2,EZ,C2,j2=C(()=>{"use strict";wt=x(R()),Hm=x(B()),q2=x(D()),T2=x(It()),Mf=x(Ae());P2();k2=(0,T2.makeStyles)()(e=>({margin:{padding:20},loading:{background:e.palette.background.paper}}));EZ=(0,q2.observer)(function({model:t}){let{progress:r,rid:n,error:i,processing:o}=t,{classes:a}=k2();return wt.default.createElement("div",{className:a.margin},wt.default.createElement(Mf.LoadingEllipses,{message:"Running NCBI 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Sf=x(Me()),E2=x(d2());Lm();var ct="https://www.ebi.ac.uk/Tools/services/rest";async function hZ({sequence:e,onProgress:t}){let r=await je(`${ct}/clustalo/run`,{method:"POST",body:new URLSearchParams({email:"colin.diesh@gmail.com",sequence:e})});return await bf({jobId:r,algorithm:"clustalo",onProgress:t}),{msa:await je(`${ct}/clustalo/result/${r}/aln-clustal_num`),tree:await je(`${ct}/clustalo/result/${r}/phylotree`)}}async function mZ({sequence:e,onProgress:t}){let r=await je(`${ct}/muscle/run`,{method:"POST",body:new URLSearchParams({email:"colin.diesh@gmail.com",format:"clw",tree:"tree1",sequence:e})});return await bf({jobId:r,algorithm:"muscle",onProgress:t}),{msa:await je(`${ct}/muscle/result/${r}/fa`),tree:await je(`${ct}/muscle/result/${r}/phylotree`)}}async function vZ({sequence:e,onProgress:t}){let r=await je(`${ct}/kalign/run`,{method:"POST",body:new URLSearchParams({email:"colin.diesh@gmail.com",stype:"protein",sequence:e})});return await bf({jobId:r,algorithm:"kalign",onProgress:t}),{msa:await je(`${ct}/kalign/result/${r}/fa`),tree:await je(`${ct}/kalign/result/${r}/phylotree`)}}async function _Z({sequence:e,onProgress:t}){let r=await je(`${ct}/mafft/run`,{method:"POST",body:new URLSearchParams({email:"colin.diesh@gmail.com",stype:"protein",sequence:e})});return await bf({jobId:r,algorithm:"mafft",onProgress:t}),{msa:await je(`${ct}/mafft/result/${r}/fa`),tree:await je(`${ct}/mafft/result/${r}/phylotree`)}}async function bf({onProgress:e,jobId:t,algorithm:r}){for(;;){for(let i=0;i<10;i++)await _f(1e3),e(`Re-checking MSA status in... ${10-i}`);let n=await je(`${ct}/${r}/status/${t}`);if(n==="FINISHED")break;if(n.includes("FAILURE"))throw new Error(`Failed to run: jobId ${t}`)}}async function m2({algorithm:e,sequence:t,onProgress:r}){switch(r(`Launching ${e} MSA...`),e){case"clustalo":return hZ({sequence:t,onProgress:r});case"muscle":return mZ({sequence:t,onProgress:r});case"kalign":return vZ({sequence:t,onProgress:r});case"mafft":return _Z({sequence:t,onProgress:r});default:throw new Error("unknown algorithm")}}Dm();function _2(e){return`${e.accession}-${e.sciname.replaceAll(" ","_")}`}function b2(e){return e.replace("-","")}async function g2({self:e}){let{blastDatabase:t,blastProgram:r,msaAlgorithm:n,proteinSequence:i}=e.blastParams,o=i.replaceAll("*","").replaceAll("&",""),{hits:a}=await v2({query:o,blastDatabase:t,blastProgram:r,onProgress:l=>{e.setProgress(l)},onRid:l=>{e.setRid(l)}}),u=[`>QUERY
+${o}`,...a.map(l=>[_2(l.description[0]??{accession:"unknown",id:"unknown",sciname:"unknown"}),b2(l.hsps[0]?.hseq??"")]).map(([l,f])=>`>${l}
+${f}`)].join(`
+`);return await m2({algorithm:n,sequence:u,onProgress:l=>{e.setProgress(l)}})}var w2=x(Me());function y2(e){return!!e&&typeof e=="object"&&"hoverFeature"in e&&"hoverPosition"in e}function S2({model:e}){let{hovered:t}=(0,w2.getSession)(e),{transcriptToMsaMap:r,connectedView:n}=e;if(n?.initialized&&r&&y2(t)){let{coord:i}=t.hoverPosition,{g2p:o}=r,a=o[i];if(a!==void 0)return e.seqCoordToRowSpecificGlobalCoord("QUERY",a+1)}}function gf({model:e,coord:t}){let{transcriptToMsaMap:r}=e;if(r===void 0)return;let n=t,i=e.seqCoordToRowSpecificGlobalCoord("QUERY",n)||0,o=e.seqCoordToRowSpecificGlobalCoord("QUERY",n+1)||0,{refName:a,p2g:u}=r,d=u[i],l=u[o];return d!==void 0&&l!==void 0?{refName:a,start:Math.min(d,l),end:Math.max(d,l)}:void 0}var O2=x(x2());function Nm(){return Se.types.compose(E2.BaseViewModel,Rm(),Se.types.model("MsaView",{connectedViewId:Se.types.maybe(Se.types.string),connectedFeature:Se.types.frozen(),connectedHighlights:Se.types.array(Se.types.model({refName:Se.types.string,start:Se.types.number,end:Se.types.number})),blastParams:Se.types.frozen(),zoomToBaseLevel:!1})).volatile(()=>({rid:void 0,progress:"",error:void 0})).views(e=>({ungappedCoordMap(t,r){let i=e.rows.find(o=>o[0]===t)?.[1];if(i&&r<i.length){let o=0,a=0;for(;a<r;a++,o++)for(;i[o]==="-";)o++;return o}}})).views(e=>({get transcriptToMsaMap(){return e.connectedFeature?(0,O2.genomeToTranscriptSeqMapping)(e.connectedFeature):void 0}})).views(e=>({get mouseCol2(){return S2({model:e})},get clickCol2(){}})).views(e=>({get processing(){return!!e.progress},get connectedView(){let{views:t}=(0,Sf.getSession)(e);return 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Pa.default.createElement(Pa.default.Fragment,null,Pa.default.createElement(pP,{model:t}),Pa.default.createElement(hP,{model:t}))}),vP=$Z;function ev(e){e.addToExtensionPoint("LinearGenomeView-TracksContainerComponent",(t=[],{model:r})=>[...t,_P.default.createElement(vP,{key:"highlight_protein_viewer_msaview",model:r})])}var If=class extends bP.default{constructor(){super(...arguments);this.name="MsaViewPlugin";this.version=lv}install(r){Vm(r),Zm(r),ev(r)}configure(r){(0,gP.isAbstractMenuManager)(r.rootModel)&&r.rootModel.appendToSubMenu(["Add"],{label:"Multiple sequence alignment view",icon:yP.default,onClick:n=>{n.addView("MsaView",{})}})}};return MP(YZ);})();
 /*! Bundled license information:
 canvas2svg/canvas2svg.js:
@@ -72,6 +72,9 @@ canvas2svg/canvas2svg.js:
    *  Copyright (c) 2014 Gliffy Inc.
    *)
+pako/dist/pako.esm.mjs:
+  (*! pako 2.1.0 https://github.com/nodeca/pako @license (MIT AND Zlib) *)
 svgcanvas/dist/svgcanvas.js:
   (*!!
    *  SVGCanvas v2.0.3
@@ -87,8 +90,5 @@ svgcanvas/dist/svgcanvas.js:
    *  Copyright (c) 2014 Gliffy Inc.
    *  Copyright (c) 2021 Zeno Zeng
    *)
-pako/dist/pako.esm.mjs:
-  (*! pako 2.1.0 https://github.com/nodeca/pako @license (MIT AND Zlib) *)
 */
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