jbrowse-plugin-msaview 2.0.0 → 2.0.1
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
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"use strict";var JBrowsePluginMsaView=(()=>{var
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"use strict";var JBrowsePluginMsaView=(()=>{var S2=Object.create;var Qo=Object.defineProperty;var x2=Object.getOwnPropertyDescriptor;var E2=Object.getOwnPropertyNames;var M2=Object.getPrototypeOf,O2=Object.prototype.hasOwnProperty;var C=(e,t)=>()=>(e&&(t=e(e=0)),t);var g=(e,t)=>()=>(t||e((t={exports:{}}).exports,t),t.exports),pt=(e,t)=>{for(var r in t)Qo(e,r,{get:t[r],enumerable:!0})},Zh=(e,t,r,n)=>{if(t&&typeof t=="object"||typeof t=="function")for(let i of E2(t))!O2.call(e,i)&&i!==r&&Qo(e,i,{get:()=>t[i],enumerable:!(n=x2(t,i))||n.enumerable});return e};var x=(e,t,r)=>(r=e!=null?S2(M2(e)):{},Zh(t||!e||!e.__esModule?Qo(r,"default",{value:e,enumerable:!0}):r,e)),A2=e=>Zh(Qo({},"__esModule",{value:!0}),e);var Jh=g((l$,Kh)=>{Kh.exports=JBrowseExports["@jbrowse/core/Plugin"]});var Le=g((c$,Qh)=>{Qh.exports=JBrowseExports["@jbrowse/core/util"]});var J=g((f$,qi)=>{function P2(e){return e&&e.__esModule?e:{default:e}}qi.exports=P2,qi.exports.__esModule=!0,qi.exports.default=qi.exports});var tm=g((d$,em)=>{em.exports=JBrowseExports["@mui/material/utils"]});var ee=g($c=>{"use strict";"use client";Object.defineProperty($c,"__esModule",{value:!0});Object.defineProperty($c,"default",{enumerable:!0,get:function(){return q2.createSvgIcon}});var q2=tm()});var te=g((h$,rm)=>{rm.exports=JBrowseExports["react/jsx-runtime"]});var nm=g(ea=>{"use strict";"use client";var k2=J();Object.defineProperty(ea,"__esModule",{value:!0});ea.default=void 0;var T2=k2(ee()),C2=te(),m$=ea.default=(0,T2.default)((0,C2.jsx)("path",{d:"M20 2H4c-1.1 0-2 .9-2 2v16c0 1.1.9 2 2 2h16c1.1 0 2-.9 2-2V4c0-1.1-.9-2-2-2M8 20H4v-4h4zm0-6H4v-4h4zm0-6H4V4h4zm6 12h-4v-4h4zm0-6h-4v-4h4zm0-6h-4V4h4zm6 12h-4v-4h4zm0-6h-4v-4h4zm0-6h-4V4h4z"}),"GridOn")});var R=g((b$,om)=>{om.exports=JBrowseExports.react});var um=g((g$,am)=>{am.exports=JBrowseExports["@jbrowse/core/pluggableElementTypes/ViewType"]});var zt=g((y$,sm)=>{sm.exports=JBrowseExports["mobx-state-tree"]});var Ht=g((w$,lm)=>{lm.exports=JBrowseExports.mobx});var D=g((S$,cm)=>{cm.exports=JBrowseExports["mobx-react"]});var B=g((x$,fm)=>{fm.exports=JBrowseExports["@mui/material"]});function R2(){let e=arguments.length>0&&arguments[0]!==void 0?arguments[0]:[],t=arguments.length>1&&arguments[1]!==void 0?arguments[1]:[];return e.length!==t.length||e.some((r,n)=>!Object.is(r,t[n]))}var $e,I2,Yc,ta,dm=C(()=>{"use client";$e=x(R()),I2=(0,$e.createContext)(null),Yc={didCatch:!1,error:null},ta=class extends $e.Component{constructor(t){super(t),this.resetErrorBoundary=this.resetErrorBoundary.bind(this),this.state=Yc}static getDerivedStateFromError(t){return{didCatch:!0,error:t}}resetErrorBoundary(){let{error:t}=this.state;if(t!==null){for(var r,n,i=arguments.length,o=new Array(i),a=0;a<i;a++)o[a]=arguments[a];(r=(n=this.props).onReset)===null||r===void 0||r.call(n,{args:o,reason:"imperative-api"}),this.setState(Yc)}}componentDidCatch(t,r){var n,i;(n=(i=this.props).onError)===null||n===void 0||n.call(i,t,r)}componentDidUpdate(t,r){let{didCatch:n}=this.state,{resetKeys:i}=this.props;if(n&&r.error!==null&&R2(t.resetKeys,i)){var o,a;(o=(a=this.props).onReset)===null||o===void 0||o.call(a,{next:i,prev:t.resetKeys,reason:"keys"}),this.setState(Yc)}}render(){let{children:t,fallbackRender:r,FallbackComponent:n,fallback:i}=this.props,{didCatch:o,error:a}=this.state,u=t;if(o){let p={error:a,resetErrorBoundary:this.resetErrorBoundary};if(typeof r=="function")u=r(p);else if(n)u=(0,$e.createElement)(n,p);else if(i===null||(0,$e.isValidElement)(i))u=i;else throw a}return(0,$e.createElement)(I2.Provider,{value:{didCatch:o,error:a,resetErrorBoundary:this.resetErrorBoundary}},u)}}});var Te=g((M$,pm)=>{pm.exports=JBrowseExports["@jbrowse/core/ui"]});async function wt(e,t,r){e.setError(void 0),t&&e.setMSAFilehandle(t),r&&e.setTreeFilehandle(r)}var Xc=C(()=>{});var hm,mm,vm,_m=C(()=>{hm=`CLUSTAL O(1.2.3) multiple sequence alignment
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UniProt/Swiss-Prot|P26898|IL2RA_SHEEP MEPSLLMWRFFVFIVVPGCVTEACHDDPPSLRNA----------MFKVLRYE----VGTM
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UniProt/Swiss-Prot|P01590|IL2RA_MOUSE MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNA----------TFKALSYK----NGTI
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UniProt/Swiss-Prot|P41690|IL2RA_FELCA MEPSLLLWGILTFVVVHGHVTELCDENPPDIQHA----------TFKALTYK----TGTM
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@@ -11,7 +11,7 @@ UniProt/Swiss-Prot|Q8BZM1|GLMN_MOUSE PLPLRSLLFLQLPLLGVGLNP----------------
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UniProt/Swiss-Prot|P36835|IL2_CAPHI -----------LLGVGLNPKFLTP------------------------------------
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UniProt/Swiss-Prot|Q7JFM4|IL2_AOTVO MLKPPLPLRSLLFLQLPLLGVGLNPKFLTPSGNEDIGGKPGTGGDFFLTSTPAGTLDVST
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UniProt/Swiss-Prot|Q29416|IL2_CANFA --------------LFLQLSLLG-------------------------------------
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`,
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`,mm=`CLUSTAL O(1.2.4) multiple sequence alignment
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sp|P69905|HBA_HUMAN MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG 60
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@@ -27,35 +27,35 @@ sp|P13786|HBAZ_CAPHI SKVVAAVGDAVKSIDNVTSALSKLSELHAYVLRVDPVNFKFLSHCLLVTLASHF
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sp|P69905|HBA_HUMAN AVHASLDKFLASVSTVLTSKYR 142
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sp|P01942|HBA_MOUSE AVHASLDKFLASVSTVLTSKYR 142
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sp|P13786|HBAZ_CAPHI DAHAAWDKFLSIVSGVLTEKYR 142
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.**: ****: ** ***.***`,Tm="(((UniProt/Swiss-Prot|P26898|IL2RA_SHEEP:0.24036,(UniProt/Swiss-Prot|P41690|IL2RA_FELCA:0.17737,(UniProt/Swiss-Prot|P01589|IL2RA_HUMAN:0.03906,UniProt/Swiss-Prot|Q5MNY4|IL2RA_MACMU:0.03787):0.13033):0.04964):0.02189,UniProt/Swiss-Prot|P01590|IL2RA_MOUSE:0.23072):0.06814,(((UniProt/Swiss-Prot|Q95118|IL2RG_BOVIN:0.09600,UniProt/Swiss-Prot|P40321|IL2RG_CANFA:0.09845):0.25333,UniProt/Swiss-Prot|Q29416|IL2_CANFA:-0.35055):0.10231,(UniProt/Swiss-Prot|P26896|IL2RB_RAT:0.33631,UniProt/Swiss-Prot|Q7JFM4|IL2_AOTVO:-0.33631):0.10166):0.01607,(UniProt/Swiss-Prot|Q8BZM1|GLMN_MOUSE:0.32378,UniProt/Swiss-Prot|P36835|IL2_CAPHI:-0.32378):0.09999)"});var Fe,ia,jm,Ut,gA,Im,Rm=C(()=>{Fe=x(R()),ia=x(B()),jm=x(D());Cm();tf();Ut=({onClick:e,model:t,children:r})=>Fe.default.createElement("li",null,Fe.default.createElement(ia.Link,{onClick:n=>{t.setError(void 0),n.preventDefault(),e()},href:"#"},Fe.default.createElement(ia.Typography,{display:"inline"},r))),gA=(0,jm.observer)(function({model:e}){return Fe.default.createElement("ul",null,Fe.default.createElement(Ut,{model:e,onClick:()=>St(e,void 0,{uri:"https://jbrowse.org/genomes/newick_trees/sarscov2phylo.pub.ft.nh",locationType:"UriLocation"})},"230k COVID-19 samples (tree only)"),Fe.default.createElement(Ut,{model:e,onClick:()=>{e.setData({msa:qm,tree:Tm})}},"Small protein MSA+tree"),Fe.default.createElement(Ut,{model:e,onClick:()=>{e.setData({msa:km})}},"Small MSA only"),Fe.default.createElement(Ut,{model:e,onClick:()=>St(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/pfam-cov2.stock",locationType:"UriLocation"})},"PFAM SARS-CoV2 multi-stockholm"),Fe.default.createElement(Ut,{model:e,onClick:()=>St(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/Lysine.stock",locationType:"UriLocation"})},"Lysine stockholm file"),Fe.default.createElement(Ut,{model:e,onClick:()=>St(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/PF01601_full.txt",locationType:"UriLocation"})},"PF01601 stockholm file (SARS-CoV2 spike protein)"),Fe.default.createElement(Ut,{model:e,onClick:()=>St(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/europe_covid.fa",locationType:"UriLocation"})},"Europe COVID full genomes (LR883044.1 and 199 other sequences)"),Fe.default.createElement(Ut,{model:e,onClick:()=>St(e,{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/rhv_test-only.aligned_with_mafft_auto.fa",locationType:"UriLocation"},{uri:"https://jbrowse.org/genomes/multiple_sequence_alignments/rhv_test-only.aligned_with_mafft_auto.nh",locationType:"UriLocation"})},"MAFFT+VeryFastTree(17.9k samples)"),Fe.default.createElement(Ut,{model:e,onClick:()=>St(e,{uri:"https://jbrowse.org/demos/ttc39a.mfa",locationType:"UriLocation"})},"Human BLAST results mfa"))}),Im=gA});var se,Lm,Me,rf,Fm,Dm=C(()=>{se=x(R()),Lm=x(D()),Me=x(B()),rf=x(Te());tf();Rm();Fm=(0,Lm.observer)(({model:e})=>{let[t,r]=(0,se.useState)(),[n,i]=(0,se.useState)(),{error:o}=e;return se.default.createElement(Me.Container,null,se.default.createElement("div",{style:{width:"50%"}},o?se.default.createElement("div",{style:{padding:20}},se.default.createElement(Me.Typography,{color:"error"},"Error: ",`${o}`)):null,se.default.createElement(Me.Typography,null,"Open an MSA file (stockholm or clustal format) and/or a tree file (newick format)."),se.default.createElement(Me.Typography,{color:"error"},"Note: you can open up just an MSA or just a tree, both are not required. Some MSA files e.g. stockholm format have an embedded tree also and this is fine, and opening a separate tree file is not required.")),se.default.createElement(Me.Grid,{container:!0,spacing:10,justifyContent:"center",alignItems:"center"},se.default.createElement(Me.Grid,{item:!0},se.default.createElement(Me.Typography,null,"MSA file or URL"),se.default.createElement(rf.FileSelector,{location:t,setLocation:r}),se.default.createElement(Me.Typography,null,"Tree file or URL"),se.default.createElement(rf.FileSelector,{location:n,setLocation:i})),se.default.createElement(Me.Grid,{item:!0},se.default.createElement(Me.Button,{onClick:()=>St(e,t,n),variant:"contained",color:"primary",disabled:!t&&!n},"Open")),se.default.createElement(Me.Grid,{item:!0},se.default.createElement(Me.Typography,null,"Examples"),se.default.createElement(Im,{model:e}))))})});var 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`).forEach((u,p)=>{let l=()=>{o||(n(mc(p)+Cx),o=new ue)},d;Ix.test(u)?(o&&n(mc(p)+gV),o=new ue):dV.test(u)?(o?i.push(o):n(mc(p)+Cx),o=null):(d=pV.exec(u))?(l(),o.gf[d[1]]=o.gf[d[1]]||[],o.gf[d[1]].push(d[2])):(d=hV.exec(u))?(l(),o.gc[d[1]]=o.gc[d[1]]||"",o.gc[d[1]]+=d[2]):(d=mV.exec(u))?(l(),o.gs[d[2]]=o.gs[d[2]]||{},o.gs[d[2]][d[1]]=o.gs[d[2]][d[1]]||[],o.gs[d[2]][d[1]].push(d[3])):(d=vV.exec(u))?(l(),o.gr[d[2]]=o.gr[d[2]]||{},o.gr[d[2]][d[1]]=o.gr[d[2]][d[1]]||"",o.gr[d[2]][d[1]]+=d[3]):(d=_V.exec(u))?(l(),o.seqdata[d[1]]||(o.seqdata[d[1]]="",o.seqname.push(d[1])),o.seqdata[d[1]]+=d[2]):bV.test(u)&&ir(mc(p)+yV)}),o&&(n("Warning: no end line //"),i.push(o)),i},EV=(e,t)=>{let r=Lp(e,t);return r.length===0&&ir("No alignments found"),r.length>1&&ir("More than one alignment found"),r[0]},MV=(e,t)=>{let r=new ue;return t=t||Object.keys(e),t.forEach(n=>r.addRow(n,e[n])),r},OV=e=>{let t=new ue;return e.forEach(r=>t.addRow(r[0],r[1])),t};ue.prototype.rows=function(){return this.seqname.length};ue.prototype.columns=function(){let e=0;return this.seqname.forEach(t=>{e=Math.max(e,this.seqdata[t].length)}),Object.keys(this.gr).forEach(t=>Object.keys(this.gr[t]).forEach(r=>{e=Math.max(e,this.gr[t][r].length)})),e};ue.prototype.allNames=function(){let e={},t=[],r=i=>{e[i]||(e[i]=!0,t.push(i))},n=i=>i.forEach(r);return n(this.seqname),n(Object.keys(this.seqdata)),Object.keys(this.gr).forEach(i=>n(Object.keys(this.gr[i]))),Object.keys(this.gs).forEach(i=>n(Object.keys(this.gs[i]))),t};ue.prototype.allTags=function(){let e={},t=r=>Object.keys(r).forEach(n=>e[n]=!0);return t(this.gc),t(this.gf),t(this.gr),t(this.gs),Object.keys(e).sort()};ue.prototype.addRow=function(e,t){return this.seqdata[e]&&ir("Duplicate row name"),this.seqname.push(e),this.seqdata[e]=t||"",this};ue.prototype.deleteRow=function(e){return this.seqdata[e]||ir("Row not found"),this.seqname=this.seqname.filter(t=>t!==e),delete this.seqdata[e],Object.keys(this.gr).forEach(t=>delete this.gr[t][e]),Object.keys(this.gs).forEach(t=>delete this.gs[t][e]),this};var _c=(e,t)=>{let r={};return Object.keys(e).forEach(n=>r[n]=t(e[n])),r},Eo=e=>_c(e,t=>t.slice(0)),jp=e=>_c(e,t=>Eo(t));ue.prototype.copy=function(){let e=new ue;return e.seqname=this.seqname.slice(0),e.seqdata=Eo(this.seqdata),e.gf=Eo(this.gf),e.gc=Eo(this.gc),e.gs=jp(this.gs),e.gr=jp(this.gr),e};var AV=(e,t)=>t.map(r=>e[r]).join(""),Ip=(e,t)=>_c(e,r=>AV(r,t)),PV=(e,t)=>_c(e,r=>Ip(r,t));ue.prototype.extractColumns=function(e){let t=this.columns(),r=e.filter(i=>i<0||i>=t);r.length&&ir("Bad column indices: "+r.join(","));let n=new ue;return n.seqname=this.seqname.slice(0),n.seqdata=Ip(this.seqdata,e),n.gf=Eo(this.gf),n.gc=Ip(this.gc,e),n.gs=jp(this.gs),n.gr=PV(this.gr,e),n};ue.prototype.extractColumnRange=function(e,t){return this.extractColumns(new Array(t+1-e).fill(0).map((r,n)=>e+n))};ue.prototype.defaultGapChars=".-";ue.prototype.seqpos2col=function(e,t){t=t||this.defaultGapChars,this.seqdata[e]||ir("Row not found");let r=this.seqdata[e];return r.split("").map((n,i)=>t.indexOf(r[i])<0?i:-1).filter(n=>n>=0)};ue.prototype.col2seqpos=function(e,t){t=t||this.defaultGapChars,this.seqdata[e]||ir("Row not found");let r=this.seqdata[e],n=-1;return r.split("").map((i,o)=>t.indexOf(r[o])<0?++n:n+.5)};function vc(e,t){for(;e.length<t;)e=" "+e;return e}function jx(e,t){for(;e.length<t;)e=e+" ";return e}function qV(e){return vc("",e)}ue.prototype.toString=function(e){e=e||{width:80,indentNames:!1};let t=this.allNames(),r=this.columns(),n=Math.max.apply(null,t.map(d=>d.length).concat([0])),i=Math.max.apply(null,this.allTags().map(d=>d.length).concat([0])),o=i?i+6:0,a=e.width?Math.max(1,e.width-n-o-1):r,u=e.indentNames?vc:jx,p=e.indentNames?(d,s)=>vc(d,i)+" "+vc(s,n):(d,s)=>jx(d+" "+s,i+n+1),l=[0];for(let d=a;d<r;d+=a)l.push(d);return`# STOCKHOLM 1.0
|
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37
37
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`+Object.keys(this.gf).sort().map(d=>this.gf[d].map(s=>"#=GF "+u(d,i)+" "+s+`
|
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38
38
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39
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-
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|
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39
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+
`).join("")).join("")).join("")+l.map(d=>Object.keys(this.gc).sort().map(s=>"#=GC "+u(s,i)+qV(n+2)+this.gc[s].substr(d,a)+`
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40
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`).join("")+t.map(s=>Object.keys(this.gr).filter(c=>this.gr[c][s]).sort().map(c=>"#=GR "+p(c,s)+" "+this.gr[c][s].substr(d,a)+`
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41
41
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`).join("")+(this.seqdata[s]?u(s,n+o)+" "+this.seqdata[s].substr(d,a)+`
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42
42
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`:"")).join("")).join(`
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43
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`)+`//
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44
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`};ue.prototype.toFasta=function(e){e=e||{width:80};let t=this.columns(),r=e.width||t,n=[0];for(let i=r;i<t;i+=r)n.push(i);return this.allNames().map(i=>this.seqdata[i]?">"+i+`
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45
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`+n.map(o=>this.seqdata[i].substr(o,r)+`
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46
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-
`).join(""):"").join("")};ue.prototype.toRowList=function(e){return this.allNames().filter(t=>this.seqdata[t]).map(t=>[t,this.seqdata[t]])};typeof
|
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47
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-
`)[Symbol.iterator]());if(t===void 0)throw new Error("No blocks parsed");let r=t.seqs.map((i,o)=>({id:t.ids[o],seq:i})),{consensus:n}=t;if(n.length!=r[0].seq.length)throw new Error(`Consensus length != sequence length. Con ${n.length} seq ${r[0].seq.length}`);return{consensus:n,alns:r}}
|
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48
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-
`)[Symbol.iterator]();return
|
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46
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+
`).join(""):"").join("")};ue.prototype.toRowList=function(e){return this.allNames().filter(t=>this.seqdata[t]).map(t=>[t,this.seqdata[t]])};typeof Rp<"u"&&(Rp.exports={sniff:wV,validate:SV,parse:EV,parseAll:Lp,fromSeqIndex:MV,fromRowList:OV,Stockholm:ue})});var Fp=g((Mte,Lx)=>{Lx.exports=Rx()});var Fx=g((Dp,Np)=>{(function(e,t){typeof define=="function"&&define.amd?define([],t):typeof Dp<"u"?t():(t(),e.FileSaver={})})(Dp,function(){"use strict";function e(u,p){return typeof p>"u"?p={autoBom:!1}:typeof p!="object"&&(console.warn("Deprecated: Expected third argument to be a object"),p={autoBom:!p}),p.autoBom&&/^\s*(?:text\/\S*|application\/xml|\S*\/\S*\+xml)\s*;.*charset\s*=\s*utf-8/i.test(u.type)?new Blob(["\uFEFF",u],{type:u.type}):u}function t(u,p,l){var d=new XMLHttpRequest;d.open("GET",u),d.responseType="blob",d.onload=function(){a(d.response,p,l)},d.onerror=function(){console.error("could not download file")},d.send()}function r(u){var p=new 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v=i.URL||i.webkitURL,h=v.createObjectURL(u);d?d.location=h:location.href=h,d=null,setTimeout(function(){v.revokeObjectURL(h)},4e4)}});i.saveAs=a.saveAs=a,typeof Np<"u"&&(Np.exports=a)})});var Nx=g((Ote,Dx)=>{Dx.exports=JBrowseExports["@jbrowse/core/util/types/mst"]});var zx=g((Ate,Bx)=>{Bx.exports=JBrowseExports["@jbrowse/core/util/io"]});function Bp(e){return{...e,branchset:e.branchset.map(t=>t.branchset.length?Bp(t):{branchset:[t],id:`${t.id}-leafnode`,name:`${t.name}-hidden`})}}var Hx=C(()=>{});function Vx({mapHeight:e,blockSize:t,viewportY:r,viewportHeight:n}){let i=Math.max(0,Math.min(r,e*t-n)),o=Math.floor(i/t),a=Math.floor((i+n-1)/t),u=[];for(let p=o;p<=a;p++)u.push(p*t);return u}function Ux({mapWidth:e,blockSize:t,viewportX:r,viewportWidth:n}){let i=Math.max(0,Math.min(r,e-n)),o=Math.floor(i/t),a=Math.floor((i+n-1)/t),u=[];for(let p=o;p<=a;p++)u.push(p*t);return u}var Wx=C(()=>{});function Gx(e,t){zp||(zp=document.createElement("canvas"));let r=zp.getContext("2d");if(!r)throw new Error("no canvas context");return r.font=r.font.replace(/\d+px/,`${t}px`),r.measureText(e).width}var zp,$x=C(()=>{});var jt,Yx,Hp,kV,TV,Xx,Zx=C(()=>{jt=x(R()),Yx=x(B()),Hp=x(D());an();kV=(0,Hp.observer)(function({track:e,model:t,offsetX:r}){let{blockSize:n,scrollX:i,bgColor:o,colorScheme:a,colWidth:u,fontSize:p,rowHeight:l,highResScaleFactor:d}=t,{model:{customColorScheme:s,data:c}}=e,f=s||a,m=(0,Yx.useTheme)(),v=(0,jt.useRef)(null),h=(0,jt.useMemo)(()=>ui(f,m),[f,m]);return(0,jt.useEffect)(()=>{if(!v.current)return;let _=v.current.getContext("2d");if(!_)return;_.resetTransform(),_.scale(d,d),_.clearRect(0,0,n,l),_.translate(-r,0),_.textAlign="center",_.font=_.font.replace(/\d+px/,`${p}px`);let y=Math.max(0,Math.floor(r/u)),w=Math.max(0,Math.ceil((r+n)/u)),S=c?.slice(y,w);for(let E=0;S&&E<S.length;E++){let M=S[E],A=f[M.toUpperCase()];if(o){let q=E*u+r-r%u;_.fillStyle=A||"white",_.fillRect(q,0,u,l),l>=10&&u>=l/2&&(_.fillStyle=h[M.toUpperCase()]||"black",_.fillText(M,q+u/2,l/2+1))}}},[p,o,n,u,l,r,h,f,d,c]),jt.default.createElement("canvas",{ref:v,height:l*d,width:n*d,style:{position:"absolute",left:i+r,width:n,height:l}})}),TV=(0,Hp.observer)(function({track:e,model:t}){let{blocksX:r,msaAreaWidth:n,rowHeight:i}=t;return jt.default.createElement("div",{style:{position:"relative",height:i,width:n,overflow:"hidden"}},r.map(o=>jt.default.createElement(kV,{key:o,track:e,model:t,offsetX:o})))}),Xx=TV});var Up=g(Ve=>{"use strict";Object.defineProperty(Ve,"__esModule",{value:!0});Ve.parseBlocks=Ve.parseBlock=Ve.getSeqBounds=Ve.getFirstNonEmptyLine=Ve.parseHeader=Ve.parseVersion=void 0;function Kx(e){let t=e.match(/\(?(\d+(\.\d+)+)\)?/);return t&&t.length>1?t[1]:""}Ve.parseVersion=Kx;function CV(e){let t=["CLUSTAL","PROBCONS","MUSCLE","MSAPROBS","Kalign"];t.some(n=>e.startsWith(n))||console.warn(`${e} is not a known CLUSTAL header: ${t.join(",")}, proceeding but could indicate an issue`);let r=Kx(e);return{info:e,version:r}}Ve.parseHeader=CV;function Jx(e){let t=e.next();for(;!t.done&&t.value.trim()==="";)t=e.next();return t.value}Ve.getFirstNonEmptyLine=Jx;function Qx(e){let t=e.split(/\s+/),r=e.slice(t[0].length),n=t[0].length+r.indexOf(t[1]),i=n+t[1].length;return[n,i]}Ve.getSeqBounds=Qx;function Vp(e){let t=Jx(e),r=[],n="";if(!t)return;for(;t;)t[0]!==" "?r.push(t):n=t,t=e.next().value;let[i,o]=Qx(r[0]),u=r.map(s=>s.split(/\s+/)).map(s=>s[0]),p=r.map(s=>s.slice(i,o)),l=n.slice(i,o),d=p[0].length-l.length;return d&&(l+=" ".repeat(d)),{ids:u,seqs:p,consensus:l}}Ve.parseBlock=Vp;function jV(e){let t,r=Vp(e);if(r!==void 0)for(;t=Vp(e);){for(let n=0;n<t.seqs.length;n++)r.seqs[n]+=t.seqs[n];r.consensus+=t.consensus}return r}Ve.parseBlocks=jV});var tE=g(Ir=>{"use strict";Object.defineProperty(Ir,"__esModule",{value:!0});Ir.parsePairwiseBlocks=Ir.parsePairwiseBlock=Ir.getSeqBounds=void 0;var IV=Up();function eE(e){let t=e.split(/\s+/),r=t[0].length+t[1].length,n=e.slice(r),i=r+n.indexOf(t[2]),o=i+t[2].length;return[i,o]}Ir.getSeqBounds=eE;function Wp(e){let t=(0,IV.getFirstNonEmptyLine)(e),r=[],n="";if(!t)return;for(;t;)t[0]!==" "?r.push(t):n=t,t=e.next().value;let[i,o]=eE(r[0]),a=r.map(s=>s.split(/\s+/)),u=a.map(s=>s[0]),p=a.map(s=>s[2]),l=n.slice(i,o),d=p[0].length-l.length;return d&&(l+=" ".repeat(d)),{ids:u,seqs:p,consensus:l}}Ir.parsePairwiseBlock=Wp;function RV(e){let t,r=Wp(e);if(r!==void 0)for(;t=Wp(e);){for(let n=0;n<t.seqs.length;n++)r.seqs[n]+=t.seqs[n];r.consensus+=t.consensus}return r}Ir.parsePairwiseBlocks=RV});var iE=g(It=>{"use strict";Object.defineProperty(It,"__esModule",{value:!0});It.parsePairwise=It.parse=It.parsePairwiseIter=It.parseClustalIter=void 0;var LV=tE(),Gp=Up();function rE(e){let t=(0,Gp.getFirstNonEmptyLine)(e);if(!t)throw new Error("Empty file received");let r=(0,Gp.parseHeader)(t),n=(0,Gp.parseBlocks)(e);if(n===void 0)throw new Error("No blocks parsed");let i=n.seqs.map((a,u)=>({id:n.ids[u],seq:a})),{consensus:o}=n;if(o.length!=i[0].seq.length)throw new Error(`Consensus length != sequence length. Con ${o.length} seq ${i[0].seq.length}`);return{consensus:o,alns:i,header:r}}It.parseClustalIter=rE;function nE(e){let t=(0,LV.parsePairwiseBlocks)(e.split(`
|
|
47
|
+
`)[Symbol.iterator]());if(t===void 0)throw new Error("No blocks parsed");let r=t.seqs.map((i,o)=>({id:t.ids[o],seq:i})),{consensus:n}=t;if(n.length!=r[0].seq.length)throw new Error(`Consensus length != sequence length. Con ${n.length} seq ${r[0].seq.length}`);return{consensus:n,alns:r}}It.parsePairwiseIter=nE;function FV(e){let t=e.split(`
|
|
48
|
+
`)[Symbol.iterator]();return rE(t)}It.parse=FV;function DV(e){let t=e.split(`
|
|
49
49
|
`).filter(r=>!r.startsWith("#")).join(`
|
|
50
|
-
`);return
|
|
51
|
-
`),[i,...o]=r.split(" "),a=o.join(" "),p=n.join("").replaceAll(/\s/g,"");return{id:i,description:a,sequence:p}})}var ko,GE=C(()=>{ko=class{MSA;constructor(t){this.MSA={seqdata:Object.fromEntries(OU(t).map(r=>[`${r.id}`,r.sequence]))}}getMSA(){return this.MSA}getRowData(){}getNames(){return Object.keys(this.MSA.seqdata)}getRow(t){return this.MSA?.seqdata[t]||""}getWidth(){let t=Object.keys(this.MSA?.seqdata)[0];return this.getRow(t).length}getStructures(){return{}}get alignmentNames(){return[]}getHeader(){return{}}getTree(){return{id:"root",name:"root",noTree:!0,branchset:this.getNames().map(t=>({id:t,branchset:[],name:t}))}}get seqConsensus(){}get secondaryStructureConsensus(){}get tracks(){return[]}}});function $E(){return Lr.types.model({tree:Lr.types.maybe(Lr.types.string),msa:Lr.types.maybe(Lr.types.string),treeMetadata:Lr.types.maybe(Lr.types.string)}).actions(e=>({setTree(t){e.tree=t},setMSA(t){e.msa=t},setTreeMetadata(t){e.treeMetadata=t}}))}var 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t){if(M=c.getSvg().cloneNode(!0),M.childNodes&&M.childNodes.length>1){for(A=M.childNodes[0];A.childNodes.length;)I=A.childNodes[0].getAttribute("id"),this.__ids[I]=I,this.__defs.appendChild(A.childNodes[0]);q=M.childNodes[1],q&&(this.__applyTransformation(q,$),E.appendChild(q))}}else(c.nodeName==="CANVAS"||c.nodeName==="IMG")&&(O=this.__createElement("image"),O.setAttribute("width",v),O.setAttribute("height",h),O.setAttribute("preserveAspectRatio","none"),(_||y||w!==c.width||S!==c.height)&&(P=this.__document.createElement("canvas"),P.width=v,P.height=h,k=P.getContext("2d"),k.drawImage(c,_,y,w,S,0,0,v,h),c=P),this.__applyTransformation(O,$),O.setAttributeNS("http://www.w3.org/1999/xlink","xlink:href",c.nodeName==="CANVAS"?c.toDataURL():c.getAttribute("src")),E.appendChild(O))},t.prototype.createPattern=function(s,c){var f=this.__document.createElementNS("http://www.w3.org/2000/svg","pattern"),m=a(this.__ids),v;return f.setAttribute("id",m),f.setAttribute("width",s.width),f.setAttribute("height",s.height),f.setAttribute("patternUnits","userSpaceOnUse"),s.nodeName==="CANVAS"||s.nodeName==="IMG"?(v=this.__document.createElementNS("http://www.w3.org/2000/svg","image"),v.setAttribute("width",s.width),v.setAttribute("height",s.height),v.setAttributeNS("http://www.w3.org/1999/xlink","xlink:href",s.nodeName==="CANVAS"?s.toDataURL():s.getAttribute("src")),f.appendChild(v),this.__defs.appendChild(f)):s instanceof t&&(f.appendChild(s.__root.childNodes[1]),this.__defs.appendChild(f)),new n(f,this)},t.prototype.setLineDash=function(s){s&&s.length>0?this.lineDash=s.join(","):this.lineDash=null},t.prototype.setTransform=function(s,c,f,m,v,h){s instanceof DOMMatrix?this.__transformMatrix=new DOMMatrix([s.a,s.b,s.c,s.d,s.e,s.f]):this.__transformMatrix=new DOMMatrix([s,c,f,m,v,h])},t.prototype.getTransform=function(){let{a:s,b:c,c:f,d:m,e:v,f:h}=this.__transformMatrix;return new DOMMatrix([s,c,f,m,v,h])},t.prototype.resetTransform=function(){this.setTransform(1,0,0,1,0,0)},t.prototype.scale=function(s,c){if(c===void 0&&(c=s),isNaN(s)||isNaN(c)||!isFinite(s)||!isFinite(c))return;let f=this.getTransform().scale(s,c);this.setTransform(f)},t.prototype.rotate=function(s){let c=this.getTransform().multiply(new DOMMatrix([Math.cos(s),Math.sin(s),-Math.sin(s),Math.cos(s),0,0]));this.setTransform(c)},t.prototype.translate=function(s,c){let f=this.getTransform().translate(s,c);this.setTransform(f)},t.prototype.transform=function(s,c,f,m,v,h){let _=this.getTransform().multiply(new DOMMatrix([s,c,f,m,v,h]));this.setTransform(_)},t.prototype.__matrixTransform=function(s,c){return new DOMPoint(s,c).matrixTransform(this.__transformMatrix)},t.prototype.__getTransformScale=function(){return{x:Math.hypot(this.__transformMatrix.a,this.__transformMatrix.b),y:Math.hypot(this.__transformMatrix.c,this.__transformMatrix.d)}},t.prototype.__getTransformRotation=function(){return Math.atan2(this.__transformMatrix.b,this.__transformMatrix.a)},t.prototype.getImageData=function(s,c,f,m,v){return mM.getImageData(this.getSvg(),this.width,this.height,s,c,f,m,v)},t.prototype.drawFocusRing=function(){},t.prototype.createImageData=function(){},t.prototype.putImageData=function(){},t.prototype.globalCompositeOperation=function(){},t}();function Fr(e){this.ctx=new vM(e),this.svg=this.ctx.__root;var t=this.svg,r=this,n=document.createElement("div");n.style.display="inline-block",n.appendChild(t),this.wrapper=n,Object.defineProperty(this,"className",{get:function(){return n.getAttribute("class")||""},set:function(i){return n.setAttribute("class",i)}}),Object.defineProperty(this,"tagName",{get:function(){return"CANVAS"},set:function(){}}),["width","height"].forEach(function(i){Object.defineProperty(r,i,{get:function(){return t.getAttribute(i)|0},set:function(o){if(!(isNaN(o)||typeof o>"u"))return r.ctx[i]=o,t.setAttribute(i,o),n[i]=o}})}),["style","id"].forEach(function(i){Object.defineProperty(r,i,{get:function(){return n[i]},set:function(o){if(typeof o<"u")return n[i]=o}})}),["getBoundingClientRect"].forEach(function(i){r[i]=function(){return t[i]()}})}Fr.prototype.getContext=function(e){if(e!=="2d")throw new Error("Unsupported type of context for SVGCanvas");return this.ctx};Fr.prototype.toObjectURL=function(){var e=new XMLSerializer().serializeToString(this.svg),t=new Blob([e],{type:"image/svg+xml;charset=utf-8"});return URL.createObjectURL(t)};Fr.prototype.toDataURL=function(e,t,r){return mM.toDataURL(this.svg,this.width,this.height,e,t,r)};Fr.prototype.addEventListener=function(){return this.svg.addEventListener.apply(this.svg,arguments)};Fr.prototype.getElement=function(){return this.wrapper};Fr.prototype.getAttribute=function(e){return this.wrapper.getAttribute(e)};Fr.prototype.setAttribute=function(e,t){this.wrapper.setAttribute(e,t)};Ec.Context=vM;Ec.Element=Fr});var SM={};ht(SM,{renderToSvg:()=>kU});async function kU(e,t){await(0,yM.when)(()=>!!e.initialized);let{width:r,height:n,scrollX:i,scrollY:o}=e,{exportType:a,theme:u,includeMinimap:p}=t;if(a==="entire")return bM({width:e.totalWidth+e.treeAreaWidth,height:e.totalHeight,theme:u,model:e,offsetY:0,offsetX:0,includeMinimap:p});if(a==="viewport")return bM({width:r,height:n,theme:u,model:e,offsetY:o,offsetX:-i,includeMinimap:p});throw new Error("unknown export type")}async function bM({width:e,height:t,offsetX:r,offsetY:n,theme:i,model:o,includeMinimap:a}){let{Context:u}=await Promise.resolve().then(()=>x(_M())),p=a?CU:IU;return(0,wM.renderToStaticMarkup)(de.default.createElement(jU,{width:e,height:t},de.default.createElement(p,{model:o},de.default.createElement(TU,{Context:u,model:o,theme:i,offsetX:r,offsetY:n,width:e,height:t}))),gM.createRoot)}function TU({model:e,theme:t,width:r,height:n,offsetX:i,offsetY:o,Context:a}){let u="tree",p="msa",{treeAreaWidth:l,colorScheme:d}=e,s=li(d,t),c=a(r,n),f=a(r,n);pc({ctx:f,offsetX:i,offsetY:o,model:e,blockSizeYOverride:n,highResScaleFactorOverride:1});let m=r-l;return _c({model:e,offsetY:o,ctx:c,theme:t,blockSizeYOverride:n,highResScaleFactorOverride:1}),dc({model:e,theme:t,offsetY:o,offsetX:i,contrastScheme:s,ctx:f,blockSizeXOverride:m,blockSizeYOverride:n,highResScaleFactorOverride:1}),de.default.createElement(de.default.Fragment,null,de.default.createElement("defs",null,de.default.createElement("clipPath",{id:u},de.default.createElement("rect",{x:0,y:0,width:l,height:n}))),de.default.createElement("defs",null,de.default.createElement("clipPath",{id:p},de.default.createElement("rect",{x:0,y:0,width:m,height:n}))),de.default.createElement("g",{clipPath:`url(#${u})`,dangerouslySetInnerHTML:{__html:c.getSvg().innerHTML}}),de.default.createElement("g",{clipPath:`url(#${p})`,transform:`translate(${l} 0)`,dangerouslySetInnerHTML:{__html:f.getSvg().innerHTML}}))}function CU({model:e,children:t}){let{minimapHeight:r,treeAreaWidth:n}=e;return de.default.createElement(de.default.Fragment,null,de.default.createElement("g",{transform:`translate(${n} 0)`},de.default.createElement(dM,{model:e})),de.default.createElement("g",{transform:`translate(0 ${r})`},t))}function jU({width:e,height:t,children:r}){return de.default.createElement("svg",{width:e,height:t,xmlns:"http://www.w3.org/2000/svg",xmlnsXlink:"http://www.w3.org/1999/xlink",viewBox:[0,0,e,t].toString()},r)}function IU({children:e}){return e}var de,gM,yM,wM,xM=C(()=>{de=x(R()),gM=x(cM()),yM=x(Vt()),wM=x(Le());bc();Dp();un();pM();Np()});function RU(){return X.types.compose(ZE(),JE(),tM(),X.types.model("MsaView",{id:_i.ElementId,featureMode:!1,subFeatureRows:!1,type:X.types.literal("MsaView"),height:X.types.optional(X.types.number,550),rowHeight:20,scrollY:0,scrollX:0,colWidth:16,treeFilehandle:X.types.maybe(_i.FileLocation),msaFilehandle:X.types.maybe(_i.FileLocation),treeMetadataFilehandle:X.types.maybe(_i.FileLocation),currentAlignment:0,collapsed:X.types.array(X.types.string),collapsed2:X.types.array(X.types.string),showOnly:X.types.maybe(X.types.string),turnedOffTracks:X.types.map(X.types.boolean),data:X.types.optional($E(),{tree:"",msa:""}),featureFilters:X.types.map(X.types.boolean)})).volatile(()=>({status:void 0,highResScaleFactor:1,loadingMSA:!1,loadingTree:!1,width:800,resizeHandleWidth:5,blockSize:1e3,mouseRow:void 0,mouseCol:void 0,mouseClickRow:void 0,mouseClickCol:void 0,nref:0,minimapHeight:56,marginLeft:20,error:void 0,annotPos:void 0,loadedInterProAnnotations:void 0,interProScanJobIds:JSON.parse((0,Lt.localStorageGetItem)("msaview-interproscanqueries")||"[]")})).actions(e=>({setLoadingMSA(t){e.loadingMSA=t},setLoadingTree(t){e.loadingTree=t},setWidth(t){e.width=t},setHeight(t){e.height=t},setError(t){e.error=t},setMousePos(t,r){e.mouseCol=t,e.mouseRow=r},setFeatureMode(t){e.featureMode=t},setSubFeatureRows(t){e.subFeatureRows=t},setMouseClickPos(t,r){e.mouseClickCol=t,e.mouseClickRow=r},setRowHeight(t){e.rowHeight=t},setColWidth(t){e.colWidth=t},setScrollY(t){e.scrollY=t},setCurrentAlignment(t){e.currentAlignment=t},toggleCollapsed(t){e.collapsed.includes(t)?e.collapsed.remove(t):e.collapsed.push(t)},toggleCollapsed2(t){e.collapsed2.includes(t)?e.collapsed2.remove(t):e.collapsed2.push(t)},setShowOnly(t){e.showOnly=t},setData(t){e.data=(0,X.cast)(t)},setMSAFilehandle(t){e.msaFilehandle=t},setTreeFilehandle(t){e.treeFilehandle=t},setMSA(t){e.data.setMSA(t)},setTree(t){e.data.setTree(t)},setTreeMetadata(t){e.data.setTreeMetadata(t)}})).views(e=>({extraViewMenuItems(){return[]},get colorScheme(){return $l[e.colorSchemeName]},get header(){return this.MSA?.getHeader()||{}},getRowData(t){return{data:this.MSA?.getRowData(t)}},get alignmentNames(){return this.MSA?.alignmentNames||[]},get noTree(){return!!this._tree.noTree},get noAnnotations(){return!e.loadedInterProAnnotations},get menuItems(){return[]},get treeMetadata(){return e.data.treeMetadata?JSON.parse(e.data.treeMetadata):{}},get MSA(){let t=e.data.msa;return t?EM.default.sniff(t)?new qo(t,e.currentAlignment):t.startsWith(">")?new ko(t):new Ao(t):null},get numColumns(){return(this.MSA?.getWidth()||0)-this.blanks.length},get _tree(){let t=e.data.tree?go(Po(e.data.tree)):this.MSA?.getTree()||{noTree:!0,branchset:[],id:"empty",name:"empty"};return th(t)},get rowNames(){return this.hierarchy.leaves().map(t=>t.data.name)},get mouseOverRowName(){let{mouseRow:t}=e;return t!==void 0?this.rowNames[t]:void 0},get root(){let t=mi(this._tree,r=>r.branchset).sum(r=>r.branchset?0:1).sort((r,n)=>Ul(r.data.length||1,n.data.length||1));if(e.showOnly){let r=t.find(n=>n.data.id===e.showOnly);r&&(t=r)}return[...e.collapsed,...e.collapsed2].map(r=>t.find(n=>n.data.id===r)).filter(Lt.notEmpty).map(r=>wp(r)),t},get msaAreaWidth(){return e.width-e.treeAreaWidth},get treeAreaWidthMinusMargin(){return e.treeAreaWidth-e.marginLeft},get blanks(){let t=[],r=this.hierarchy.leaves().map(n=>this.MSA?.getRow(n.data.name)).filter(n=>!!n);for(let n=0;n<r[0]?.length;n++){let i=0;for(let o of r)o[n]==="-"&&i++;i===r.length&&t.push(n)}return t},get rows(){let t=this.MSA;return this.hierarchy.leaves().map(r=>[r.data.name,t?.getRow(r.data.name)]).filter(r=>!!r[1])},get columns(){return Object.fromEntries(this.rows.map((t,r)=>[t[0],this.columns2d[r]]))},get columns2d(){return this.rows.map(t=>t[1]).map(t=>bp(this.blanks,t))},get fontSize(){return Math.min(Math.max(6,e.rowHeight-8),18)},get colStats(){let t=[],r=this.columns2d;for(let n of r)for(let i=0;i<n.length;i++){let o=t[i]||{};o[n[i]]||(o[n[i]]=0),o[n[i]]++,t[i]=o}return t},get hierarchy(){let t=this.root;return $p().size([this.totalHeight,e.treeWidth]).separation(()=>1)(t),gp(t,t.data.length=0,e.treeWidth/yp(t)),t},get totalHeight(){return this.root.leaves().length*e.rowHeight}})).views(e=>({get totalWidth(){return e.numColumns*e.colWidth}})).views(e=>({get initialized(){return(e.data.msa||e.data.tree)&&!e.error},get blocksX(){return AE({viewportWidth:e.msaAreaWidth,viewportX:-e.scrollX,blockSize:e.blockSize,mapWidth:e.totalWidth})},get blocksY(){return OE({viewportHeight:e.height,viewportY:-e.scrollY,blockSize:e.blockSize,mapHeight:e.totalHeight})}})).views(e=>({get blocks2d(){let t=[];for(let r of e.blocksY)for(let n of e.blocksX)t.push([n,r]);return t},get isLoading(){return e.loadingMSA||e.loadingTree},get maxScrollX(){return-e.totalWidth+(e.msaAreaWidth-100)}})).actions(e=>({zoomIn(){e.colWidth=Math.ceil(e.colWidth*1.5),e.rowHeight=Math.ceil(e.rowHeight*1.5),e.scrollX=ci(e.maxScrollX,e.scrollX,0)},zoomOut(){e.colWidth=Math.max(1,Math.floor(e.colWidth*.75)),e.rowHeight=Math.max(1.5,Math.floor(e.rowHeight*.75)),e.scrollX=ci(e.maxScrollX,e.scrollX,0)},setLoadedInterProAnnotations(t){e.loadedInterProAnnotations=t},doScrollY(t){e.scrollY=ci(-e.totalHeight+10,e.scrollY+t,0)},doScrollX(t){e.scrollX=ci(e.maxScrollX,e.scrollX+t,0)},setScrollX(t){e.scrollX=ci(e.maxScrollX,t,0)},toggleTrack(t){e.turnedOffTracks.has(t)?e.turnedOffTracks.delete(t):e.turnedOffTracks.set(t,!0)},addInterProScanJobId(t){e.interProScanJobIds=[...e.interProScanJobIds,{jobId:t,date:+Date.now()}]},setStatus(t){e.status=t}})).views(e=>({get labelsWidth(){let t=0,{rowHeight:r,hierarchy:n,treeMetadata:i,fontSize:o}=e;if(r>5)for(let a of n.leaves())t=Math.max(qE(i[a.data.name]?.genome||a.data.name,o),t);return t},get secondaryStructureConsensus(){return e.MSA?.secondaryStructureConsensus},get seqConsensus(){return e.MSA?.seqConsensus},get conservation(){if(e.columns2d.length)for(let t=0;t<e.columns2d[0].length;t++){let r=[];for(let n of e.columns2d)r.push(n[t])}return["a"]},get adapterTrackModels(){return e.MSA?.tracks.map(t=>({model:{...t,data:t.data?bp(e.blanks,t.data):void 0,height:e.rowHeight},ReactComponent:CE}))||[]},get tracks(){return this.adapterTrackModels},get turnedOnTracks(){return this.tracks.filter(t=>!e.turnedOffTracks.has(t.model.id))},globalCoordToRowSpecificSeqCoord(t,r){let{rowNames:n,rows:i}=e,o=n.indexOf(t);if(o!==-1&&i[o]){let a=i[o][1],u=0;for(let p=0;p<r;p++)if(a[p]!=="-")u++;else if(u>=r)break;return u}return 0},seqCoordToRowSpecificGlobalCoord(t,r){let{rowNames:n,rows:i}=e,o=n.indexOf(t);if(o!==-1&&i[o]){let a=i[o][1],u=0,p=0;for(;u<r;p++)if(a[p]!=="-")u++;else if(u>=r)break;return p}return 0}})).views(e=>({get totalTrackAreaHeight(){return(0,Lt.sum)(e.turnedOnTracks.map(t=>t.model.height))},get tidyTypes(){let t=new Map;if(this.tidyAnnotations)for(let{name:r,accession:n,description:i}of this.tidyAnnotations)t.set(n,{name:r,accession:n,description:i});return t},get tidyAnnotations(){let t=[],{loadedInterProAnnotations:r}=e;if(r)for(let[n,i]of Object.entries(r))for(let{signature:o,locations:a}of i.matches){let{entry:u}=o;if(u){let{name:p,accession:l,description:d}=u;for(let{start:s,end:c}of a)t.push({id:n,name:p,accession:l,description:d,start:s,end:c})}}return t.sort((n,i)=>Sp(i)-Sp(n))},get tidyFilteredAnnotations(){return this.tidyAnnotations.filter(t=>e.featureFilters.get(t.accession))},get tidyFilteredGatheredAnnotations(){return(0,Lt.groupBy)(this.tidyFilteredAnnotations,t=>t.id)}})).views(e=>({get fillPalette(){let t=[...e.tidyTypes.keys()],r=0,n={};for(let i of t){let o=Math.min(t.length-1,Op.length-1);n[i]=Op[o][r],r++}return n},get strokePalette(){return Object.fromEntries(Object.entries(this.fillPalette).map(([t,r])=>[t,Ce(r).darken(.1).toHex()]))}})).actions(e=>({async loadInterProScanResults(t){e.setStatus({msg:"Loading "+t});let r=await fh(t);e.setStatus(),e.setLoadedInterProAnnotations(Object.fromEntries(r.results.map(n=>[n.xref[0].id,n])))},async queryInterProScan(t){let{rows:r}=e;if(r.length>140)throw new Error("Too many sequences, please run InterProScan offline");let n=await uM({algorithm:"interproscan",programs:t,seq:r.map(i=>`>${i[0]}
|
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50
|
+
`);return nE(t)}It.parsePairwise=DV});var oE,Mo,aE=C(()=>{oE=x(iE()),Mo=class{MSA;constructor(t){this.MSA=(0,oE.parse)(t)}getMSA(){return this.MSA}getRow(t){return this.MSA.alns.find(r=>r.id===t)?.seq||""}getWidth(){return this.MSA.alns[0].seq.length}getRowData(){}getHeader(){return this.MSA.header}getNames(){return this.MSA.alns.map(t=>t.id)}getStructures(){return{}}get alignmentNames(){return[]}getTree(){return{id:"root",name:"root",noTree:!0,branchset:this.getNames().map(t=>({id:t,name:t,branchset:[]}))}}get seqConsensus(){return this.MSA.consensus}get secondaryStructureConsensus(){}get tracks(){return[]}}});function Oo(e){let t=[],r={},n=e.split(/\s*(;|\(|\)|,|:)\s*/);for(let i=0;i<n.length;i++){let o=n[i],a={};switch(o){case"(":r.branchset=[a],t.push(r),r=a;break;case",":t.at(-1)?.branchset.push(a),r=a;break;case")":r=t.pop();break;case":":break;default:{let u=n[i-1];u===")"||u==="("||u===","?r.name=o:u===":"&&(r.length=parseFloat(o))}}}return r}var $p=C(()=>{});var uE,Ao,sE=C(()=>{uE=x(Fp());$p();an();Ao=class{data;MSA;constructor(t,r){let n=uE.default.parseAll(t);this.data=n,this.MSA=n[r]}getMSA(){return this.MSA}getRow(t){return this.MSA?.seqdata[t]||""}getWidth(){let t=Object.keys(this.MSA?.seqdata)[0];return this.getRow(t).length}get alignmentNames(){return this.data.map((t,r)=>t.gf.DE?.[0]||`Alignment ${r+1}`)}getHeader(){return{General:this.MSA.gf,Accessions:this.MSA.gs?.AC,Dbxref:this.MSA.gs?.DR}}getRowData(t){return{name:t,accession:this.MSA.gs?.AC?.[t],dbxref:this.MSA.gs?.DR?.[t]}}getNames(){return Object.keys(this.MSA.seqdata)}getSeqCoords(){}getStructures(){let t=/PDB; +(\S+) +(\S); ([0-9]+)-([0-9]+)/,r=this.MSA,n=Object.entries(r.gs?.DR||{}).map(([o,a])=>[o,t.exec(a)]).filter(o=>!!o[1]).map(([o,a])=>{let u=a[1].toLowerCase(),p=a[2],l=+a[3],d=+a[4];return{id:o,pdb:u,chain:p,startPos:l,endPos:d}}),i={};for(let o of n){let{id:a,...u}=o;i[a]||(i[a]=[]),i[a].push(u)}return i}getTree(){let t=this.MSA?.gf?.NH?.[0];return t?_o(Oo(t)):{id:"root",name:"root",noTree:!0,branchset:this.getNames().map(r=>({id:r,branchset:[],name:r}))}}get seqConsensus(){return this.MSA.gc?.seq_cons}get secondaryStructureConsensus(){return this.MSA.gc?.SS_cons}get tracks(){return[{id:"seqConsensus",name:"Sequence consensus",data:this.seqConsensus,customColorScheme:{}},{id:"secondaryStruct",name:"Secondary-structure",data:this.secondaryStructureConsensus,customColorScheme:{">":"pink","<":"lightblue"}}]}}});function NV(e){return e.split(">").filter(t=>/\S/.test(t)).map(t=>{let[r,...n]=t.split(`
|
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51
|
+
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totalTrackAreaHeight(){return(0,Rt.sum)(e.turnedOnTracks.map(t=>t.model.height))},get tidyTypes(){let t=new Map;if(this.tidyAnnotations)for(let{name:r,accession:n,description:i}of this.tidyAnnotations)t.set(n,{name:r,accession:n,description:i});return t},get tidyAnnotations(){let t=[],{loadedInterProAnnotations:r}=e;if(r)for(let[n,i]of Object.entries(r))for(let{signature:o,locations:a}of i.matches){let{entry:u}=o;if(u){let{name:p,accession:l,description:d}=u;for(let{start:s,end:c}of a)t.push({id:n,name:p,accession:l,description:d,start:s,end:c})}}return t.sort((n,i)=>vp(i)-vp(n))},get tidyFilteredAnnotations(){return this.tidyAnnotations.filter(t=>e.featureFilters.get(t.accession))},get tidyFilteredGatheredAnnotations(){return(0,Rt.groupBy)(this.tidyFilteredAnnotations,t=>t.id)}})).views(e=>({get fillPalette(){let t=[...e.tidyTypes.keys()],r=0,n={};for(let i of t){let o=Math.min(t.length-1,yp.length-1);n[i]=yp[o][r],r++}return n},get strokePalette(){return 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`),onProgress:i=>e.setStatus(i),onJobId:i=>e.addInterProScanJobId(i)});e.setLoadedInterProAnnotations(Object.fromEntries(n.results.map(i=>[i.xref[0].id,i])))},reset(){(0,gt.transaction)(()=>{e.setData({tree:"",msa:""}),e.setScrollY(0),e.setScrollX(0),e.setCurrentAlignment(0),e.setTreeFilehandle(void 0),e.setMSAFilehandle(void 0)})},async exportSVG(t){let{renderToSvg:r}=await Promise.resolve().then(()=>(BE(),NE)),n=await r(e,t),i=new Blob([n],{type:"image/svg+xml"});(0,HE.saveAs)(i,"image.svg")},incrementRef(){e.nref++},initFilter(t){e.featureFilters.get(t)===void 0&&e.featureFilters.set(t,!0)},setFilter(t,r){e.featureFilters.set(t,r)},afterCreate(){(0,X.addDisposer)(e,(0,gt.autorun)(()=>{for(let t of 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QV({rid:e,onProgress:t}){for(;;){for(let i=0;i<20;i++)await yc(1e3),t(`Re-checking BLAST status in... ${20-i}`);let n=await Ue(`${qo}?CMD=Get&FORMAT_OBJECT=SearchInfo&RID=${e}`);if(!n.match(/\s+Status=WAITING/m)){if(n.match(/\s+Status=FAILED/m))throw new Error(`BLAST ${e} failed; please report to blast-help@ncbi.nlm.nih.gov`);if(n.match(/\s+Status=READY/m)){if(n.match(/\s+ThereAreHits=yes/m))return!0;throw new Error("No hits found")}}}}var qo,nh=C(()=>{"use strict";th();qo="https://blast.ncbi.nlm.nih.gov/blast/Blast.cgi"});var rM=g(Sc=>{"use strict";Object.defineProperty(Sc,"__esModule",{value:!0});Sc.genomeToTranscriptSeqMapping=void 0;function eU(e){var t,r;let n=e.strand,i=e.refName,o=(r=(t=e.subfeatures)===null||t===void 0?void 0:t.filter(l=>l.type==="CDS").sort((l,d)=>n*(l.start-d.start)))!==null&&r!==void 0?r:[],a={},u={},p=0;if(n!==-1)for(let l of o)for(let d=l.start;d<l.end;d++){let s=Math.floor(p++/3);a[d]=s,u[s]||(u[s]=d)}else for(let l of o)for(let d=l.end;d>l.start;d--){let 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nU({rid:e,progress:t}){let{classes:r}=cM();return st.default.createElement("div",{className:r.loading},e?st.default.createElement(ah,{rid:e}):null,st.default.createElement(uh.Typography,null,t))}var st,uh,sM,lM,Ac,cM,iU,fM,dM=C(()=>{"use strict";st=x(R()),uh=x(B()),sM=x(D()),lM=x(St()),Ac=x(Te());uM();cM=(0,lM.makeStyles)()(e=>({margin:{padding:20},loading:{background:e.palette.background.paper}}));iU=(0,sM.observer)(function({model:t}){let{progress:r,rid:n,error:i,processing:o}=t,{classes:a}=cM();return st.default.createElement("div",{className:a.margin},st.default.createElement(Ac.LoadingEllipses,{message:"Running NCBI BLAST",variant:"h5"}),i?st.default.createElement(rU,{rid:n,error:i}):n?st.default.createElement(nU,{rid:n,progress:r}):null,st.default.createElement(uh.Typography,null,o||"Initializing BLAST query"))}),fM=iU});var hM={};pt(hM,{default:()=>aU});var Pc,pM,oU,aU,mM=C(()=>{"use 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rh({jobId:r,algorithm:"clustalo",onProgress:t}),{msa:await Ue(`${Lt}/clustalo/result/${r}/aln-clustal_num`),tree:await Ue(`${Lt}/clustalo/result/${r}/phylotree`)}}async function ZV({sequence:e,onProgress:t}){let r=await Ue(`${Lt}/muscle/run`,{method:"POST",body:new URLSearchParams({email:"colin.diesh@gmail.com",format:"clw",tree:"tree1",sequence:e})});return await rh({jobId:r,algorithm:"muscle",onProgress:t}),{msa:await Ue(`${Lt}/muscle/result/${r}/fa`),tree:await Ue(`${Lt}/muscle/result/${r}/phylotree`)}}async function KV({sequence:e,onProgress:t}){let r=await Ue(`${Lt}/kalign/run`,{method:"POST",body:new URLSearchParams({email:"colin.diesh@gmail.com",stype:"protein",sequence:e})});return await rh({jobId:r,algorithm:"kalign",onProgress:t}),{msa:await Ue(`${Lt}/kalign/result/${r}/fa`),tree:await Ue(`${Lt}/kalign/result/${r}/phylotree`)}}async function rh({onProgress:e,jobId:t,algorithm:r}){for(;;){for(let i=0;i<10;i++)await yc(1e3),e(`Re-checking MSA status in... ${10-i}`);if(await Ue(`${Lt}/${r}/status/${t}`)==="FINISHED")break}}async function YE({algorithm:e,sequence:t,onProgress:r}){if(r(`Launching ${e} MSA...`),e==="clustalo")return XV({sequence:t,onProgress:r});if(e==="muscle")return ZV({sequence:t,onProgress:r});if(e==="kalign")return KV({sequence:t,onProgress:r});throw new Error("unknown algorithm")}nh();function ZE(e){return`${e.accession}-${e.sciname.replaceAll(" ","_")}`}function KE(e){return e.replace("-","")}async function JE({self:e}){let{blastDatabase:t,blastProgram:r,msaAlgorithm:n,proteinSequence:i}=e.blastParams,o=i.replaceAll("*","").replaceAll("&",""),{hits:a}=await XE({query:o,blastDatabase:t,blastProgram:r,onProgress:l=>e.setProgress(l),onRid:l=>e.setRid(l)}),u=[`>QUERY
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${h}`:"Loading...",InputProps:{readOnly:!0,classes:{input:i.textAreaFont}}}),xe.default.createElement(
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`).map(r=>r.trim()).filter(r=>!!r)}function Mi(e){let t=e.length;for(;--t>=0;)e[t]=0}var oW=0,o2=1,aW=2,uW=3,sW=258,Jh=29,Xo=256,zo=Xo+1+Jh,Si=30,Qh=19,a2=2*zo+1,mn=15,qh=16,lW=7,em=256,u2=16,s2=17,l2=18,Vh=new Uint8Array([0,0,0,0,0,0,0,0,1,1,1,1,2,2,2,2,3,3,3,3,4,4,4,4,5,5,5,5,0]),zc=new Uint8Array([0,0,0,0,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13]),cW=new Uint8Array([0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,7]),c2=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]),fW=512,ur=new Array((zo+2)*2);Mi(ur);var Do=new Array(Si*2);Mi(Do);var Ho=new Array(fW);Mi(Ho);var Vo=new Array(sW-uW+1);Mi(Vo);var tm=new Array(Jh);Mi(tm);var Hc=new Array(Si);Mi(Hc);function kh(e,t,r,n,i){this.static_tree=e,this.extra_bits=t,this.extra_base=r,this.elems=n,this.max_length=i,this.has_stree=e&&e.length}var f2,d2,p2;function Th(e,t){this.dyn_tree=e,this.max_code=0,this.stat_desc=t}var h2=e=>e<256?Ho[e]:Ho[256+(e>>>7)],Uo=(e,t)=>{e.pending_buf[e.pending++]=t&255,e.pending_buf[e.pending++]=t>>>8&255},Ge=(e,t,r)=>{e.bi_valid>qh-r?(e.bi_buf|=t<<e.bi_valid&65535,Uo(e,e.bi_buf),e.bi_buf=t>>qh-e.bi_valid,e.bi_valid+=r-qh):(e.bi_buf|=t<<e.bi_valid&65535,e.bi_valid+=r)},Nt=(e,t,r)=>{Ge(e,r[t*2],r[t*2+1])},m2=(e,t)=>{let r=0;do r|=e&1,e>>>=1,r<<=1;while(--t>0);return r>>>1},dW=e=>{e.bi_valid===16?(Uo(e,e.bi_buf),e.bi_buf=0,e.bi_valid=0):e.bi_valid>=8&&(e.pending_buf[e.pending++]=e.bi_buf&255,e.bi_buf>>=8,e.bi_valid-=8)},pW=(e,t)=>{let r=t.dyn_tree,n=t.max_code,i=t.stat_desc.static_tree,o=t.stat_desc.has_stree,a=t.stat_desc.extra_bits,u=t.stat_desc.extra_base,p=t.stat_desc.max_length,l,d,s,c,f,m,v=0;for(c=0;c<=mn;c++)e.bl_count[c]=0;for(r[e.heap[e.heap_max]*2+1]=0,l=e.heap_max+1;l<a2;l++)d=e.heap[l],c=r[r[d*2+1]*2+1]+1,c>p&&(c=p,v++),r[d*2+1]=c,!(d>n)&&(e.bl_count[c]++,f=0,d>=u&&(f=a[d-u]),m=r[d*2],e.opt_len+=m*(c+f),o&&(e.static_len+=m*(i[d*2+1]+f)));if(v!==0){do{for(c=p-1;e.bl_count[c]===0;)c--;e.bl_count[c]--,e.bl_count[c+1]+=2,e.bl_count[p]--,v-=2}while(v>0);for(c=p;c!==0;c--)for(d=e.bl_count[c];d!==0;)s=e.heap[--l],!(s>n)&&(r[s*2+1]!==c&&(e.opt_len+=(c-r[s*2+1])*r[s*2],r[s*2+1]=c),d--)}},v2=(e,t,r)=>{let n=new Array(mn+1),i=0,o,a;for(o=1;o<=mn;o++)i=i+r[o-1]<<1,n[o]=i;for(a=0;a<=t;a++){let u=e[a*2+1];u!==0&&(e[a*2]=m2(n[u]++,u))}},hW=()=>{let e,t,r,n,i,o=new Array(mn+1);for(r=0,n=0;n<Jh-1;n++)for(tm[n]=r,e=0;e<1<<Vh[n];e++)Vo[r++]=n;for(Vo[r-1]=n,i=0,n=0;n<16;n++)for(Hc[n]=i,e=0;e<1<<zc[n];e++)Ho[i++]=n;for(i>>=7;n<Si;n++)for(Hc[n]=i<<7,e=0;e<1<<zc[n]-7;e++)Ho[256+i++]=n;for(t=0;t<=mn;t++)o[t]=0;for(e=0;e<=143;)ur[e*2+1]=8,e++,o[8]++;for(;e<=255;)ur[e*2+1]=9,e++,o[9]++;for(;e<=279;)ur[e*2+1]=7,e++,o[7]++;for(;e<=287;)ur[e*2+1]=8,e++,o[8]++;for(v2(ur,zo+1,o),e=0;e<Si;e++)Do[e*2+1]=5,Do[e*2]=m2(e,5);f2=new kh(ur,Vh,Xo+1,zo,mn),d2=new kh(Do,zc,0,Si,mn),p2=new kh(new Array(0),cW,0,Qh,lW)},_2=e=>{let t;for(t=0;t<zo;t++)e.dyn_ltree[t*2]=0;for(t=0;t<Si;t++)e.dyn_dtree[t*2]=0;for(t=0;t<Qh;t++)e.bl_tree[t*2]=0;e.dyn_ltree[em*2]=1,e.opt_len=e.static_len=0,e.sym_next=e.matches=0},b2=e=>{e.bi_valid>8?Uo(e,e.bi_buf):e.bi_valid>0&&(e.pending_buf[e.pending++]=e.bi_buf),e.bi_buf=0,e.bi_valid=0},wO=(e,t,r,n)=>{let i=t*2,o=r*2;return e[i]<e[o]||e[i]===e[o]&&n[t]<=n[r]},Ch=(e,t,r)=>{let n=e.heap[r],i=r<<1;for(;i<=e.heap_len&&(i<e.heap_len&&wO(t,e.heap[i+1],e.heap[i],e.depth)&&i++,!wO(t,n,e.heap[i],e.depth));)e.heap[r]=e.heap[i],r=i,i<<=1;e.heap[r]=n},SO=(e,t,r)=>{let n,i,o=0,a,u;if(e.sym_next!==0)do n=e.pending_buf[e.sym_buf+o++]&255,n+=(e.pending_buf[e.sym_buf+o++]&255)<<8,i=e.pending_buf[e.sym_buf+o++],n===0?Nt(e,i,t):(a=Vo[i],Nt(e,a+Xo+1,t),u=Vh[a],u!==0&&(i-=tm[a],Ge(e,i,u)),n--,a=h2(n),Nt(e,a,r),u=zc[a],u!==0&&(n-=Hc[a],Ge(e,n,u)));while(o<e.sym_next);Nt(e,em,t)},Uh=(e,t)=>{let r=t.dyn_tree,n=t.stat_desc.static_tree,i=t.stat_desc.has_stree,o=t.stat_desc.elems,a,u,p=-1,l;for(e.heap_len=0,e.heap_max=a2,a=0;a<o;a++)r[a*2]!==0?(e.heap[++e.heap_len]=p=a,e.depth[a]=0):r[a*2+1]=0;for(;e.heap_len<2;)l=e.heap[++e.heap_len]=p<2?++p:0,r[l*2]=1,e.depth[l]=0,e.opt_len--,i&&(e.static_len-=n[l*2+1]);for(t.max_code=p,a=e.heap_len>>1;a>=1;a--)Ch(e,r,a);l=o;do a=e.heap[1],e.heap[1]=e.heap[e.heap_len--],Ch(e,r,1),u=e.heap[1],e.heap[--e.heap_max]=a,e.heap[--e.heap_max]=u,r[l*2]=r[a*2]+r[u*2],e.depth[l]=(e.depth[a]>=e.depth[u]?e.depth[a]:e.depth[u])+1,r[a*2+1]=r[u*2+1]=l,e.heap[1]=l++,Ch(e,r,1);while(e.heap_len>=2);e.heap[--e.heap_max]=e.heap[1],pW(e,t),v2(r,p,e.bl_count)},xO=(e,t,r)=>{let n,i=-1,o,a=t[0*2+1],u=0,p=7,l=4;for(a===0&&(p=138,l=3),t[(r+1)*2+1]=65535,n=0;n<=r;n++)o=a,a=t[(n+1)*2+1],!(++u<p&&o===a)&&(u<l?e.bl_tree[o*2]+=u:o!==0?(o!==i&&e.bl_tree[o*2]++,e.bl_tree[u2*2]++):u<=10?e.bl_tree[s2*2]++:e.bl_tree[l2*2]++,u=0,i=o,a===0?(p=138,l=3):o===a?(p=6,l=3):(p=7,l=4))},EO=(e,t,r)=>{let n,i=-1,o,a=t[0*2+1],u=0,p=7,l=4;for(a===0&&(p=138,l=3),n=0;n<=r;n++)if(o=a,a=t[(n+1)*2+1],!(++u<p&&o===a)){if(u<l)do Nt(e,o,e.bl_tree);while(--u!==0);else o!==0?(o!==i&&(Nt(e,o,e.bl_tree),u--),Nt(e,u2,e.bl_tree),Ge(e,u-3,2)):u<=10?(Nt(e,s2,e.bl_tree),Ge(e,u-3,3)):(Nt(e,l2,e.bl_tree),Ge(e,u-11,7));u=0,i=o,a===0?(p=138,l=3):o===a?(p=6,l=3):(p=7,l=4)}},mW=e=>{let t;for(xO(e,e.dyn_ltree,e.l_desc.max_code),xO(e,e.dyn_dtree,e.d_desc.max_code),Uh(e,e.bl_desc),t=Qh-1;t>=3&&e.bl_tree[c2[t]*2+1]===0;t--);return e.opt_len+=3*(t+1)+5+5+4,t},vW=(e,t,r,n)=>{let i;for(Ge(e,t-257,5),Ge(e,r-1,5),Ge(e,n-4,4),i=0;i<n;i++)Ge(e,e.bl_tree[c2[i]*2+1],3);EO(e,e.dyn_ltree,t-1),EO(e,e.dyn_dtree,r-1)},_W=e=>{let t=4093624447,r;for(r=0;r<=31;r++,t>>>=1)if(t&1&&e.dyn_ltree[r*2]!==0)return 0;if(e.dyn_ltree[9*2]!==0||e.dyn_ltree[10*2]!==0||e.dyn_ltree[13*2]!==0)return 1;for(r=32;r<Xo;r++)if(e.dyn_ltree[r*2]!==0)return 1;return 0},MO=!1,bW=e=>{MO||(hW(),MO=!0),e.l_desc=new Th(e.dyn_ltree,f2),e.d_desc=new Th(e.dyn_dtree,d2),e.bl_desc=new Th(e.bl_tree,p2),e.bi_buf=0,e.bi_valid=0,_2(e)},g2=(e,t,r,n)=>{Ge(e,(oW<<1)+(n?1:0),3),b2(e),Uo(e,r),Uo(e,~r),r&&e.pending_buf.set(e.window.subarray(t,t+r),e.pending),e.pending+=r},gW=e=>{Ge(e,o2<<1,3),Nt(e,em,ur),dW(e)},yW=(e,t,r,n)=>{let i,o,a=0;e.level>0?(e.strm.data_type===2&&(e.strm.data_type=_W(e)),Uh(e,e.l_desc),Uh(e,e.d_desc),a=mW(e),i=e.opt_len+3+7>>>3,o=e.static_len+3+7>>>3,o<=i&&(i=o)):i=o=r+5,r+4<=i&&t!==-1?g2(e,t,r,n):e.strategy===4||o===i?(Ge(e,(o2<<1)+(n?1:0),3),SO(e,ur,Do)):(Ge(e,(aW<<1)+(n?1:0),3),vW(e,e.l_desc.max_code+1,e.d_desc.max_code+1,a+1),SO(e,e.dyn_ltree,e.dyn_dtree)),_2(e),n&&b2(e)},wW=(e,t,r)=>(e.pending_buf[e.sym_buf+e.sym_next++]=t,e.pending_buf[e.sym_buf+e.sym_next++]=t>>8,e.pending_buf[e.sym_buf+e.sym_next++]=r,t===0?e.dyn_ltree[r*2]++:(e.matches++,t--,e.dyn_ltree[(Vo[r]+Xo+1)*2]++,e.dyn_dtree[h2(t)*2]++),e.sym_next===e.sym_end),SW=bW,xW=g2,EW=yW,MW=wW,OW=gW,AW={_tr_init:SW,_tr_stored_block:xW,_tr_flush_block:EW,_tr_tally:MW,_tr_align:OW},PW=(e,t,r,n)=>{let i=e&65535|0,o=e>>>16&65535|0,a=0;for(;r!==0;){a=r>2e3?2e3:r,r-=a;do i=i+t[n++]|0,o=o+i|0;while(--a);i%=65521,o%=65521}return i|o<<16|0},Wo=PW,qW=()=>{let e,t=[];for(var r=0;r<256;r++){e=r;for(var n=0;n<8;n++)e=e&1?3988292384^e>>>1:e>>>1;t[r]=e}return t},kW=new Uint32Array(qW()),TW=(e,t,r,n)=>{let i=kW,o=n+r;e^=-1;for(let a=n;a<o;a++)e=e>>>8^i[(e^t[a])&255];return e^-1},ge=TW,bn={2:"need dictionary",1:"stream end",0:"","-1":"file error","-2":"stream error","-3":"data error","-4":"insufficient memory","-5":"buffer error","-6":"incompatible version"},Oi={Z_NO_FLUSH:0,Z_PARTIAL_FLUSH:1,Z_SYNC_FLUSH:2,Z_FULL_FLUSH:3,Z_FINISH:4,Z_BLOCK:5,Z_TREES:6,Z_OK:0,Z_STREAM_END:1,Z_NEED_DICT:2,Z_ERRNO:-1,Z_STREAM_ERROR:-2,Z_DATA_ERROR:-3,Z_MEM_ERROR:-4,Z_BUF_ERROR:-5,Z_NO_COMPRESSION:0,Z_BEST_SPEED:1,Z_BEST_COMPRESSION:9,Z_DEFAULT_COMPRESSION:-1,Z_FILTERED:1,Z_HUFFMAN_ONLY:2,Z_RLE:3,Z_FIXED:4,Z_DEFAULT_STRATEGY:0,Z_BINARY:0,Z_TEXT:1,Z_UNKNOWN:2,Z_DEFLATED:8},{_tr_init:CW,_tr_stored_block:Wh,_tr_flush_block:jW,_tr_tally:Br,_tr_align:IW}=AW,{Z_NO_FLUSH:zr,Z_PARTIAL_FLUSH:RW,Z_FULL_FLUSH:LW,Z_FINISH:ct,Z_BLOCK:OO,Z_OK:Ee,Z_STREAM_END:AO,Z_STREAM_ERROR:Bt,Z_DATA_ERROR:FW,Z_BUF_ERROR:jh,Z_DEFAULT_COMPRESSION:DW,Z_FILTERED:NW,Z_HUFFMAN_ONLY:Lc,Z_RLE:BW,Z_FIXED:zW,Z_DEFAULT_STRATEGY:HW,Z_UNKNOWN:VW,Z_DEFLATED:Wc}=Oi,UW=9,WW=15,GW=8,$W=29,YW=256,Gh=YW+1+$W,XW=30,ZW=19,KW=2*Gh+1,JW=15,V=3,Nr=258,zt=Nr+V+1,QW=32,xi=42,rm=57,$h=69,Yh=73,Xh=91,Zh=103,vn=113,Lo=666,Ie=1,Ai=2,gn=3,Pi=4,eG=3,_n=(e,t)=>(e.msg=bn[t],t),PO=e=>e*2-(e>4?9:0),Dr=e=>{let t=e.length;for(;--t>=0;)e[t]=0},tG=e=>{let t,r,n,i=e.w_size;t=e.hash_size,n=t;do r=e.head[--n],e.head[n]=r>=i?r-i:0;while(--t);t=i,n=t;do r=e.prev[--n],e.prev[n]=r>=i?r-i:0;while(--t)},rG=(e,t,r)=>(t<<e.hash_shift^r)&e.hash_mask,Hr=rG,rt=e=>{let t=e.state,r=t.pending;r>e.avail_out&&(r=e.avail_out),r!==0&&(e.output.set(t.pending_buf.subarray(t.pending_out,t.pending_out+r),e.next_out),e.next_out+=r,t.pending_out+=r,e.total_out+=r,e.avail_out-=r,t.pending-=r,t.pending===0&&(t.pending_out=0))},nt=(e,t)=>{jW(e,e.block_start>=0?e.block_start:-1,e.strstart-e.block_start,t),e.block_start=e.strstart,rt(e.strm)},Y=(e,t)=>{e.pending_buf[e.pending++]=t},Ro=(e,t)=>{e.pending_buf[e.pending++]=t>>>8&255,e.pending_buf[e.pending++]=t&255},Kh=(e,t,r,n)=>{let i=e.avail_in;return i>n&&(i=n),i===0?0:(e.avail_in-=i,t.set(e.input.subarray(e.next_in,e.next_in+i),r),e.state.wrap===1?e.adler=Wo(e.adler,t,i,r):e.state.wrap===2&&(e.adler=ge(e.adler,t,i,r)),e.next_in+=i,e.total_in+=i,i)},y2=(e,t)=>{let r=e.max_chain_length,n=e.strstart,i,o,a=e.prev_length,u=e.nice_match,p=e.strstart>e.w_size-zt?e.strstart-(e.w_size-zt):0,l=e.window,d=e.w_mask,s=e.prev,c=e.strstart+Nr,f=l[n+a-1],m=l[n+a];e.prev_length>=e.good_match&&(r>>=2),u>e.lookahead&&(u=e.lookahead);do if(i=t,!(l[i+a]!==m||l[i+a-1]!==f||l[i]!==l[n]||l[++i]!==l[n+1])){n+=2,i++;do;while(l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&n<c);if(o=Nr-(c-n),n=c-Nr,o>a){if(e.match_start=t,a=o,o>=u)break;f=l[n+a-1],m=l[n+a]}}while((t=s[t&d])>p&&--r!==0);return a<=e.lookahead?a:e.lookahead},Ei=e=>{let t=e.w_size,r,n,i;do{if(n=e.window_size-e.lookahead-e.strstart,e.strstart>=t+(t-zt)&&(e.window.set(e.window.subarray(t,t+t-n),0),e.match_start-=t,e.strstart-=t,e.block_start-=t,e.insert>e.strstart&&(e.insert=e.strstart),tG(e),n+=t),e.strm.avail_in===0)break;if(r=Kh(e.strm,e.window,e.strstart+e.lookahead,n),e.lookahead+=r,e.lookahead+e.insert>=V)for(i=e.strstart-e.insert,e.ins_h=e.window[i],e.ins_h=Hr(e,e.ins_h,e.window[i+1]);e.insert&&(e.ins_h=Hr(e,e.ins_h,e.window[i+V-1]),e.prev[i&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=i,i++,e.insert--,!(e.lookahead+e.insert<V)););}while(e.lookahead<zt&&e.strm.avail_in!==0)},w2=(e,t)=>{let r=e.pending_buf_size-5>e.w_size?e.w_size:e.pending_buf_size-5,n,i,o,a=0,u=e.strm.avail_in;do{if(n=65535,o=e.bi_valid+42>>3,e.strm.avail_out<o||(o=e.strm.avail_out-o,i=e.strstart-e.block_start,n>i+e.strm.avail_in&&(n=i+e.strm.avail_in),n>o&&(n=o),n<r&&(n===0&&t!==ct||t===zr||n!==i+e.strm.avail_in)))break;a=t===ct&&n===i+e.strm.avail_in?1:0,Wh(e,0,0,a),e.pending_buf[e.pending-4]=n,e.pending_buf[e.pending-3]=n>>8,e.pending_buf[e.pending-2]=~n,e.pending_buf[e.pending-1]=~n>>8,rt(e.strm),i&&(i>n&&(i=n),e.strm.output.set(e.window.subarray(e.block_start,e.block_start+i),e.strm.next_out),e.strm.next_out+=i,e.strm.avail_out-=i,e.strm.total_out+=i,e.block_start+=i,n-=i),n&&(Kh(e.strm,e.strm.output,e.strm.next_out,n),e.strm.next_out+=n,e.strm.avail_out-=n,e.strm.total_out+=n)}while(a===0);return u-=e.strm.avail_in,u&&(u>=e.w_size?(e.matches=2,e.window.set(e.strm.input.subarray(e.strm.next_in-e.w_size,e.strm.next_in),0),e.strstart=e.w_size,e.insert=e.strstart):(e.window_size-e.strstart<=u&&(e.strstart-=e.w_size,e.window.set(e.window.subarray(e.w_size,e.w_size+e.strstart),0),e.matches<2&&e.matches++,e.insert>e.strstart&&(e.insert=e.strstart)),e.window.set(e.strm.input.subarray(e.strm.next_in-u,e.strm.next_in),e.strstart),e.strstart+=u,e.insert+=u>e.w_size-e.insert?e.w_size-e.insert:u),e.block_start=e.strstart),e.high_water<e.strstart&&(e.high_water=e.strstart),a?Pi:t!==zr&&t!==ct&&e.strm.avail_in===0&&e.strstart===e.block_start?Ai:(o=e.window_size-e.strstart,e.strm.avail_in>o&&e.block_start>=e.w_size&&(e.block_start-=e.w_size,e.strstart-=e.w_size,e.window.set(e.window.subarray(e.w_size,e.w_size+e.strstart),0),e.matches<2&&e.matches++,o+=e.w_size,e.insert>e.strstart&&(e.insert=e.strstart)),o>e.strm.avail_in&&(o=e.strm.avail_in),o&&(Kh(e.strm,e.window,e.strstart,o),e.strstart+=o,e.insert+=o>e.w_size-e.insert?e.w_size-e.insert:o),e.high_water<e.strstart&&(e.high_water=e.strstart),o=e.bi_valid+42>>3,o=e.pending_buf_size-o>65535?65535:e.pending_buf_size-o,r=o>e.w_size?e.w_size:o,i=e.strstart-e.block_start,(i>=r||(i||t===ct)&&t!==zr&&e.strm.avail_in===0&&i<=o)&&(n=i>o?o:i,a=t===ct&&e.strm.avail_in===0&&n===i?1:0,Wh(e,e.block_start,n,a),e.block_start+=n,rt(e.strm)),a?gn:Ie)},Ih=(e,t)=>{let r,n;for(;;){if(e.lookahead<zt){if(Ei(e),e.lookahead<zt&&t===zr)return Ie;if(e.lookahead===0)break}if(r=0,e.lookahead>=V&&(e.ins_h=Hr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),r!==0&&e.strstart-r<=e.w_size-zt&&(e.match_length=y2(e,r)),e.match_length>=V)if(n=Br(e,e.strstart-e.match_start,e.match_length-V),e.lookahead-=e.match_length,e.match_length<=e.max_lazy_match&&e.lookahead>=V){e.match_length--;do e.strstart++,e.ins_h=Hr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart;while(--e.match_length!==0);e.strstart++}else e.strstart+=e.match_length,e.match_length=0,e.ins_h=e.window[e.strstart],e.ins_h=Hr(e,e.ins_h,e.window[e.strstart+1]);else n=Br(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++;if(n&&(nt(e,!1),e.strm.avail_out===0))return Ie}return e.insert=e.strstart<V-1?e.strstart:V-1,t===ct?(nt(e,!0),e.strm.avail_out===0?gn:Pi):e.sym_next&&(nt(e,!1),e.strm.avail_out===0)?Ie:Ai},yi=(e,t)=>{let r,n,i;for(;;){if(e.lookahead<zt){if(Ei(e),e.lookahead<zt&&t===zr)return Ie;if(e.lookahead===0)break}if(r=0,e.lookahead>=V&&(e.ins_h=Hr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),e.prev_length=e.match_length,e.prev_match=e.match_start,e.match_length=V-1,r!==0&&e.prev_length<e.max_lazy_match&&e.strstart-r<=e.w_size-zt&&(e.match_length=y2(e,r),e.match_length<=5&&(e.strategy===NW||e.match_length===V&&e.strstart-e.match_start>4096)&&(e.match_length=V-1)),e.prev_length>=V&&e.match_length<=e.prev_length){i=e.strstart+e.lookahead-V,n=Br(e,e.strstart-1-e.prev_match,e.prev_length-V),e.lookahead-=e.prev_length-1,e.prev_length-=2;do++e.strstart<=i&&(e.ins_h=Hr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart);while(--e.prev_length!==0);if(e.match_available=0,e.match_length=V-1,e.strstart++,n&&(nt(e,!1),e.strm.avail_out===0))return Ie}else 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r=No.deflateInit2(this.strm,t.level,t.method,t.windowBits,t.memLevel,t.strategy);if(r!==Vc)throw new Error(bn[r]);if(t.header&&No.deflateSetHeader(this.strm,t.header),t.dictionary){let n;if(typeof t.dictionary=="string"?n=$o.string2buf(t.dictionary):A2.call(t.dictionary)==="[object ArrayBuffer]"?n=new Uint8Array(t.dictionary):n=t.dictionary,r=No.deflateSetDictionary(this.strm,n),r!==Vc)throw new Error(bn[r]);this._dict_set=!0}}Ko.prototype.push=function(e,t){let r=this.strm,n=this.options.chunkSize,i,o;if(this.ended)return!1;for(t===~~t?o=t:o=t===!0?CG:qG,typeof e=="string"?r.input=$o.string2buf(e):A2.call(e)==="[object ArrayBuffer]"?r.input=new Uint8Array(e):r.input=e,r.next_in=0,r.avail_in=r.input.length;;){if(r.avail_out===0&&(r.output=new Uint8Array(n),r.next_out=0,r.avail_out=n),(o===kG||o===TG)&&r.avail_out<=6){this.onData(r.output.subarray(0,r.next_out)),r.avail_out=0;continue}if(i=No.deflate(r,o),i===jG)return r.next_out>0&&this.onData(r.output.subarray(0,r.next_out)),i=No.deflateEnd(this.strm),this.onEnd(i),this.ended=!0,i===Vc;if(r.avail_out===0){this.onData(r.output);continue}if(o>0&&r.next_out>0){this.onData(r.output.subarray(0,r.next_out)),r.avail_out=0;continue}if(r.avail_in===0)break}return!0};Ko.prototype.onData=function(e){this.chunks.push(e)};Ko.prototype.onEnd=function(e){e===Vc&&(this.result=Gc.flattenChunks(this.chunks)),this.chunks=[],this.err=e,this.msg=this.strm.msg};function nm(e,t){let r=new Ko(t);if(r.push(e,!0),r.err)throw r.msg||bn[r.err];return r.result}function FG(e,t){return t=t||{},t.raw=!0,nm(e,t)}function DG(e,t){return t=t||{},t.gzip=!0,nm(e,t)}var NG=Ko,BG=nm,zG=FG,HG=DG,VG=Oi,UG={Deflate:NG,deflate:BG,deflateRaw:zG,gzip:HG,constants:VG},Fc=16209,WG=16191,GG=function(t,r){let n,i,o,a,u,p,l,d,s,c,f,m,v,h,_,y,w,S,E,M,A,q,O,P,k=t.state;n=t.next_in,O=t.input,i=n+(t.avail_in-5),o=t.next_out,P=t.output,a=o-(r-t.avail_out),u=o+(t.avail_out-257),p=k.dmax,l=k.wsize,d=k.whave,s=k.wnext,c=k.window,f=k.hold,m=k.bits,v=k.lencode,h=k.distcode,_=(1<<k.lenbits)-1,y=(1<<k.distbits)-1;e:do{m<15&&(f+=O[n++]<<m,m+=8,f+=O[n++]<<m,m+=8),w=v[f&_];t:for(;;){if(S=w>>>24,f>>>=S,m-=S,S=w>>>16&255,S===0)P[o++]=w&65535;else if(S&16){E=w&65535,S&=15,S&&(m<S&&(f+=O[n++]<<m,m+=8),E+=f&(1<<S)-1,f>>>=S,m-=S),m<15&&(f+=O[n++]<<m,m+=8,f+=O[n++]<<m,m+=8),w=h[f&y];r:for(;;){if(S=w>>>24,f>>>=S,m-=S,S=w>>>16&255,S&16){if(M=w&65535,S&=15,m<S&&(f+=O[n++]<<m,m+=8,m<S&&(f+=O[n++]<<m,m+=8)),M+=f&(1<<S)-1,M>p){t.msg="invalid distance too far back",k.mode=Fc;break e}if(f>>>=S,m-=S,S=o-a,M>S){if(S=M-S,S>d&&k.sane){t.msg="invalid distance too far back",k.mode=Fc;break e}if(A=0,q=c,s===0){if(A+=l-S,S<E){E-=S;do P[o++]=c[A++];while(--S);A=o-M,q=P}}else if(s<S){if(A+=l+s-S,S-=s,S<E){E-=S;do P[o++]=c[A++];while(--S);if(A=0,s<E){S=s,E-=S;do P[o++]=c[A++];while(--S);A=o-M,q=P}}}else if(A+=s-S,S<E){E-=S;do P[o++]=c[A++];while(--S);A=o-M,q=P}for(;E>2;)P[o++]=q[A++],P[o++]=q[A++],P[o++]=q[A++],E-=3;E&&(P[o++]=q[A++],E>1&&(P[o++]=q[A++]))}else{A=o-M;do P[o++]=P[A++],P[o++]=P[A++],P[o++]=P[A++],E-=3;while(E>2);E&&(P[o++]=P[A++],E>1&&(P[o++]=P[A++]))}}else if(S&64){t.msg="invalid distance code",k.mode=Fc;break e}else{w=h[(w&65535)+(f&(1<<S)-1)];continue r}break}}else if(S&64)if(S&32){k.mode=WG;break e}else{t.msg="invalid literal/length code",k.mode=Fc;break e}else{w=v[(w&65535)+(f&(1<<S)-1)];continue t}break}}while(n<i&&o<u);E=m>>3,n-=E,m-=E<<3,f&=(1<<m)-1,t.next_in=n,t.next_out=o,t.avail_in=n<i?5+(i-n):5-(n-i),t.avail_out=o<u?257+(u-o):257-(o-u),k.hold=f,k.bits=m},wi=15,qO=852,kO=592,TO=0,Rh=1,CO=2,$G=new Uint16Array([3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0]),YG=new Uint8Array([16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78]),XG=new Uint16Array([1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0]),ZG=new Uint8Array([16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64]),KG=(e,t,r,n,i,o,a,u)=>{let p=u.bits,l=0,d=0,s=0,c=0,f=0,m=0,v=0,h=0,_=0,y=0,w,S,E,M,A,q=null,O,P=new Uint16Array(wi+1),k=new Uint16Array(wi+1),I=null,$,N,ie;for(l=0;l<=wi;l++)P[l]=0;for(d=0;d<n;d++)P[t[r+d]]++;for(f=p,c=wi;c>=1&&P[c]===0;c--);if(f>c&&(f=c),c===0)return i[o++]=1<<24|64<<16|0,i[o++]=1<<24|64<<16|0,u.bits=1,0;for(s=1;s<c&&P[s]===0;s++);for(f<s&&(f=s),h=1,l=1;l<=wi;l++)if(h<<=1,h-=P[l],h<0)return-1;if(h>0&&(e===TO||c!==1))return-1;for(k[1]=0,l=1;l<wi;l++)k[l+1]=k[l]+P[l];for(d=0;d<n;d++)t[r+d]!==0&&(a[k[t[r+d]]++]=d);if(e===TO?(q=I=a,O=20):e===Rh?(q=$G,I=YG,O=257):(q=XG,I=ZG,O=0),y=0,d=0,l=s,A=o,m=f,v=0,E=-1,_=1<<f,M=_-1,e===Rh&&_>qO||e===CO&&_>kO)return 1;for(;;){$=l-v,a[d]+1<O?(N=0,ie=a[d]):a[d]>=O?(N=I[a[d]-O],ie=q[a[d]-O]):(N=96,ie=0),w=1<<l-v,S=1<<m,s=S;do S-=w,i[A+(y>>v)+S]=$<<24|N<<16|ie|0;while(S!==0);for(w=1<<l-1;y&w;)w>>=1;if(w!==0?(y&=w-1,y+=w):y=0,d++,--P[l]===0){if(l===c)break;l=t[r+a[d]]}if(l>f&&(y&M)!==E){for(v===0&&(v=f),A+=s,m=l-v,h=1<<m;m+v<c&&(h-=P[m+v],!(h<=0));)m++,h<<=1;if(_+=1<<m,e===Rh&&_>qO||e===CO&&_>kO)return 1;E=y&M,i[E]=f<<24|m<<16|A-o|0}}return y!==0&&(i[A+y]=l-v<<24|64<<16|0),u.bits=f,0},Bo=KG,JG=0,P2=1,q2=2,{Z_FINISH:jO,Z_BLOCK:QG,Z_TREES:Dc,Z_OK:yn,Z_STREAM_END:e$,Z_NEED_DICT:t$,Z_STREAM_ERROR:ft,Z_DATA_ERROR:k2,Z_MEM_ERROR:T2,Z_BUF_ERROR:r$,Z_DEFLATED:IO}=Oi,$c=16180,RO=16181,LO=16182,FO=16183,DO=16184,NO=16185,BO=16186,zO=16187,HO=16188,VO=16189,Uc=16190,ar=16191,Lh=16192,UO=16193,Fh=16194,WO=16195,GO=16196,$O=16197,YO=16198,Nc=16199,Bc=16200,XO=16201,ZO=16202,KO=16203,JO=16204,QO=16205,Dh=16206,e2=16207,t2=16208,ne=16209,C2=16210,j2=16211,n$=852,i$=592,o$=15,a$=o$,r2=e=>(e>>>24&255)+(e>>>8&65280)+((e&65280)<<8)+((e&255)<<24);function u$(){this.strm=null,this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new Uint16Array(320),this.work=new Uint16Array(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}var wn=e=>{if(!e)return 1;let t=e.state;return!t||t.strm!==e||t.mode<$c||t.mode>j2?1:0},I2=e=>{if(wn(e))return ft;let t=e.state;return e.total_in=e.total_out=t.total=0,e.msg="",t.wrap&&(e.adler=t.wrap&1),t.mode=$c,t.last=0,t.havedict=0,t.flags=-1,t.dmax=32768,t.head=null,t.hold=0,t.bits=0,t.lencode=t.lendyn=new Int32Array(n$),t.distcode=t.distdyn=new Int32Array(i$),t.sane=1,t.back=-1,yn},R2=e=>{if(wn(e))return ft;let t=e.state;return t.wsize=0,t.whave=0,t.wnext=0,I2(e)},L2=(e,t)=>{let r;if(wn(e))return ft;let n=e.state;return t<0?(r=0,t=-t):(r=(t>>4)+5,t<48&&(t&=15)),t&&(t<8||t>15)?ft:(n.window!==null&&n.wbits!==t&&(n.window=null),n.wrap=r,n.wbits=t,R2(e))},F2=(e,t)=>{if(!e)return ft;let r=new u$;e.state=r,r.strm=e,r.window=null,r.mode=$c;let n=L2(e,t);return n!==yn&&(e.state=null),n},s$=e=>F2(e,a$),n2=!0,Nh,Bh,l$=e=>{if(n2){Nh=new Int32Array(512),Bh=new Int32Array(32);let t=0;for(;t<144;)e.lens[t++]=8;for(;t<256;)e.lens[t++]=9;for(;t<280;)e.lens[t++]=7;for(;t<288;)e.lens[t++]=8;for(Bo(P2,e.lens,0,288,Nh,0,e.work,{bits:9}),t=0;t<32;)e.lens[t++]=5;Bo(q2,e.lens,0,32,Bh,0,e.work,{bits:5}),n2=!1}e.lencode=Nh,e.lenbits=9,e.distcode=Bh,e.distbits=5},D2=(e,t,r,n)=>{let i,o=e.state;return o.window===null&&(o.wsize=1<<o.wbits,o.wnext=0,o.whave=0,o.window=new Uint8Array(o.wsize)),n>=o.wsize?(o.window.set(t.subarray(r-o.wsize,r),0),o.wnext=0,o.whave=o.wsize):(i=o.wsize-o.wnext,i>n&&(i=n),o.window.set(t.subarray(r-n,r-n+i),o.wnext),n-=i,n?(o.window.set(t.subarray(r-n,r),0),o.wnext=n,o.whave=o.wsize):(o.wnext+=i,o.wnext===o.wsize&&(o.wnext=0),o.whave<o.wsize&&(o.whave+=i))),0},c$=(e,t)=>{let r,n,i,o,a,u,p,l,d,s,c,f,m,v,h=0,_,y,w,S,E,M,A,q,O=new Uint8Array(4),P,k,I=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]);if(wn(e)||!e.output||!e.input&&e.avail_in!==0)return ft;r=e.state,r.mode===ar&&(r.mode=Lh),a=e.next_out,i=e.output,p=e.avail_out,o=e.next_in,n=e.input,u=e.avail_in,l=r.hold,d=r.bits,s=u,c=p,q=yn;e:for(;;)switch(r.mode){case $c:if(r.wrap===0){r.mode=Lh;break}for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&2&&l===35615){r.wbits===0&&(r.wbits=15),r.check=0,O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0),l=0,d=0,r.mode=RO;break}if(r.head&&(r.head.done=!1),!(r.wrap&1)||(((l&255)<<8)+(l>>8))%31){e.msg="incorrect header check",r.mode=ne;break}if((l&15)!==IO){e.msg="unknown compression method",r.mode=ne;break}if(l>>>=4,d-=4,A=(l&15)+8,r.wbits===0&&(r.wbits=A),A>15||A>r.wbits){e.msg="invalid window size",r.mode=ne;break}r.dmax=1<<r.wbits,r.flags=0,e.adler=r.check=1,r.mode=l&512?VO:ar,l=0,d=0;break;case RO:for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.flags=l,(r.flags&255)!==IO){e.msg="unknown compression method",r.mode=ne;break}if(r.flags&57344){e.msg="unknown header flags set",r.mode=ne;break}r.head&&(r.head.text=l>>8&1),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0)),l=0,d=0,r.mode=LO;case LO:for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.head&&(r.head.time=l),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,O[2]=l>>>16&255,O[3]=l>>>24&255,r.check=ge(r.check,O,4,0)),l=0,d=0,r.mode=FO;case FO:for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.head&&(r.head.xflags=l&255,r.head.os=l>>8),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0)),l=0,d=0,r.mode=DO;case DO:if(r.flags&1024){for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.length=l,r.head&&(r.head.extra_len=l),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0)),l=0,d=0}else r.head&&(r.head.extra=null);r.mode=NO;case NO:if(r.flags&1024&&(f=r.length,f>u&&(f=u),f&&(r.head&&(A=r.head.extra_len-r.length,r.head.extra||(r.head.extra=new Uint8Array(r.head.extra_len)),r.head.extra.set(n.subarray(o,o+f),A)),r.flags&512&&r.wrap&4&&(r.check=ge(r.check,n,f,o)),u-=f,o+=f,r.length-=f),r.length))break e;r.length=0,r.mode=BO;case BO:if(r.flags&2048){if(u===0)break e;f=0;do A=n[o+f++],r.head&&A&&r.length<65536&&(r.head.name+=String.fromCharCode(A));while(A&&f<u);if(r.flags&512&&r.wrap&4&&(r.check=ge(r.check,n,f,o)),u-=f,o+=f,A)break e}else r.head&&(r.head.name=null);r.length=0,r.mode=zO;case zO:if(r.flags&4096){if(u===0)break e;f=0;do A=n[o+f++],r.head&&A&&r.length<65536&&(r.head.comment+=String.fromCharCode(A));while(A&&f<u);if(r.flags&512&&r.wrap&4&&(r.check=ge(r.check,n,f,o)),u-=f,o+=f,A)break e}else r.head&&(r.head.comment=null);r.mode=HO;case HO:if(r.flags&512){for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&4&&l!==(r.check&65535)){e.msg="header crc mismatch",r.mode=ne;break}l=0,d=0}r.head&&(r.head.hcrc=r.flags>>9&1,r.head.done=!0),e.adler=r.check=0,r.mode=ar;break;case VO:for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}e.adler=r.check=r2(l),l=0,d=0,r.mode=Uc;case Uc:if(r.havedict===0)return e.next_out=a,e.avail_out=p,e.next_in=o,e.avail_in=u,r.hold=l,r.bits=d,t$;e.adler=r.check=1,r.mode=ar;case ar:if(t===QG||t===Dc)break e;case Lh:if(r.last){l>>>=d&7,d-=d&7,r.mode=Dh;break}for(;d<3;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}switch(r.last=l&1,l>>>=1,d-=1,l&3){case 0:r.mode=UO;break;case 1:if(l$(r),r.mode=Nc,t===Dc){l>>>=2,d-=2;break e}break;case 2:r.mode=GO;break;case 3:e.msg="invalid block type",r.mode=ne}l>>>=2,d-=2;break;case UO:for(l>>>=d&7,d-=d&7;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if((l&65535)!==(l>>>16^65535)){e.msg="invalid stored block lengths",r.mode=ne;break}if(r.length=l&65535,l=0,d=0,r.mode=Fh,t===Dc)break e;case Fh:r.mode=WO;case WO:if(f=r.length,f){if(f>u&&(f=u),f>p&&(f=p),f===0)break e;i.set(n.subarray(o,o+f),a),u-=f,o+=f,p-=f,a+=f,r.length-=f;break}r.mode=ar;break;case GO:for(;d<14;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.nlen=(l&31)+257,l>>>=5,d-=5,r.ndist=(l&31)+1,l>>>=5,d-=5,r.ncode=(l&15)+4,l>>>=4,d-=4,r.nlen>286||r.ndist>30){e.msg="too many length or distance symbols",r.mode=ne;break}r.have=0,r.mode=$O;case $O:for(;r.have<r.ncode;){for(;d<3;){if(u===0)break 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rA.default{constructor(){super(...arguments);this.name="MsaViewPlugin";this.version=gm}install(r){xh(r),am(r),cm(r)}configure(r){(0,nA.isAbstractMenuManager)(r.rootModel)&&r.rootModel.appendToSubMenu(["Add"],{label:"Multiple sequence alignment view",icon:iA.default,onClick:n=>{n.addView("MsaView",{})}})}};return cA(Y$);})();
|
|
56
|
+
`);return await YE({algorithm:n,sequence:u,onProgress:l=>e.setProgress(l)})}var eM=x(Le());function QE(e){return!!e&&typeof e=="object"&&"hoverFeature"in e&&"hoverPosition"in e}function tM({model:e}){let{hovered:t}=(0,eM.getSession)(e),{transcriptToMsaMap:r,connectedView:n}=e;if(n?.initialized&&r&&QE(t)){let{coord:i}=t.hoverPosition,{g2p:o}=r,a=o[i];if(a!==void 0)return e.seqCoordToRowSpecificGlobalCoord("QUERY",a+1)}}function wc({model:e,coord:t}){let{transcriptToMsaMap:r}=e;if(t===void 0||r===void 0)return;let n=t-1,i=e.globalCoordToRowSpecificSeqCoord("QUERY",n)||0,o=e.globalCoordToRowSpecificSeqCoord("QUERY",n+1)||0,{refName:a,p2g:u}=r,p=u[i],l=u[o];return p!==void 0&&l!==void 0?{refName:a,start:Math.min(p,l),end:Math.max(p,l)}:void 0}var iM=x(rM());function ih(){return me.types.compose(nM.BaseViewModel,Qp(),me.types.model("MsaView",{connectedViewId:me.types.maybe(me.types.string),connectedFeature:me.types.frozen(),connectedHighlights:me.types.array(me.types.model({refName:me.types.string,start:me.types.number,end:me.types.number})),blastParams:me.types.frozen(),zoomToBaseLevel:!1})).volatile(()=>({rid:void 0,progress:"",error:void 0})).views(e=>({ungappedCoordMap(t,r){let i=e.rows.find(o=>o[0]===t)?.[1];if(i&&r<i.length){let o=0,a=0;for(;a<r;a++,o++)for(;i[o]==="-";)o++;return o}}})).views(e=>({get transcriptToMsaMap(){return console.log(e.connectedFeature),e.connectedFeature?(0,iM.genomeToTranscriptSeqMapping)(e.connectedFeature):void 0}})).views(e=>({get mouseCol2(){return tM({model:e})},get clickCol2(){}})).views(e=>({get processing(){return!!e.progress},get connectedView(){let{views:t}=(0,vi.getSession)(e);return 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kM({newViewTitle:e,view:t,feature:r}){return(0,qM.getSession)(t).addView("MsaView",{type:"MsaView",displayName:e,connectedViewId:t.id,connectedFeature:r.toJSON(),treeAreaWidth:250,treeWidth:100,drawNodeBubbles:!0,labelsAlignRight:!0,colWidth:10,rowHeight:12,colorSchemeName:"percent_identity_dynamic"})}var vU=(0,CM.makeStyles)()({dialogContent:{width:"80em"},textAreaFont:{fontFamily:"Courier New"}}),_U=(0,TM.observer)(function({handleClose:t,feature:r,model:n}){let{classes:i}=vU(),o=(0,jM.getContainingView)(n),[a,u]=(0,xe.useState)("nr"),[p,l]=(0,xe.useState)("clustalo"),d=ko(r),[s,c]=(0,xe.useState)(et(d[0])),f=d.find(w=>et(w)===s),{sequence:m,error:v}=AM({view:o,feature:f}),h=m&&!("error"in m)?wM({seq:m.seq,selectedTranscript:f}):"",_=["nr","nr_cluster_seq"],y=["clustalo","muscle","kalign","mafft"];return 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${h}`:"Loading...",InputProps:{readOnly:!0,classes:{input:i.textAreaFont}}}),xe.default.createElement(yt.DialogActions,null,xe.default.createElement(yt.Button,{color:"primary",variant:"contained",onClick:()=>{kM({feature:f,view:o,newViewTitle:`NCBI BLAST - ${dh(r)} - ${dn(f)} - ${p}`}).setBlastParams({blastProgram:"blastp",blastDatabase:a,msaAlgorithm:p,selectedTranscript:f,proteinSequence:h}),t()},disabled:!h},"Submit"),xe.default.createElement(yt.Button,{color:"secondary",variant:"contained",onClick:()=>t()},"Cancel")))}),RM=_U;var LM=RM;var pe=x(R()),o2=x(D()),a2=x(Te()),Ge=x(B()),Hc=x(Le()),u2=x(St());async function FM(){let e=await fetch("https://jbrowse.org/demos/msaview/knownCanonical/list.txt");if(!e.ok)throw new Error(`HTTP ${e.status} fetching list ${await e.text()}`);return(await e.text()).split(`
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`).map(r=>r.trim()).filter(r=>!!r)}function xi(e){let t=e.length;for(;--t>=0;)e[t]=0}var bU=0,SO=1,gU=2,yU=3,wU=258,Fh=29,$o=256,No=$o+1+Fh,yi=30,Dh=19,xO=2*No+1,pn=15,hh=16,SU=7,Nh=256,EO=16,MO=17,OO=18,Ph=new Uint8Array([0,0,0,0,0,0,0,0,1,1,1,1,2,2,2,2,3,3,3,3,4,4,4,4,5,5,5,5,0]),Rc=new Uint8Array([0,0,0,0,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13]),xU=new Uint8Array([0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,7]),AO=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]),EU=512,ar=new Array((No+2)*2);xi(ar);var Lo=new Array(yi*2);xi(Lo);var Bo=new Array(EU);xi(Bo);var zo=new Array(wU-yU+1);xi(zo);var Bh=new Array(Fh);xi(Bh);var Lc=new Array(yi);xi(Lc);function mh(e,t,r,n,i){this.static_tree=e,this.extra_bits=t,this.extra_base=r,this.elems=n,this.max_length=i,this.has_stree=e&&e.length}var PO,qO,kO;function vh(e,t){this.dyn_tree=e,this.max_code=0,this.stat_desc=t}var TO=e=>e<256?Bo[e]:Bo[256+(e>>>7)],Ho=(e,t)=>{e.pending_buf[e.pending++]=t&255,e.pending_buf[e.pending++]=t>>>8&255},We=(e,t,r)=>{e.bi_valid>hh-r?(e.bi_buf|=t<<e.bi_valid&65535,Ho(e,e.bi_buf),e.bi_buf=t>>hh-e.bi_valid,e.bi_valid+=r-hh):(e.bi_buf|=t<<e.bi_valid&65535,e.bi_valid+=r)},Dt=(e,t,r)=>{We(e,r[t*2],r[t*2+1])},CO=(e,t)=>{let r=0;do r|=e&1,e>>>=1,r<<=1;while(--t>0);return r>>>1},MU=e=>{e.bi_valid===16?(Ho(e,e.bi_buf),e.bi_buf=0,e.bi_valid=0):e.bi_valid>=8&&(e.pending_buf[e.pending++]=e.bi_buf&255,e.bi_buf>>=8,e.bi_valid-=8)},OU=(e,t)=>{let 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Array(pn+1);for(r=0,n=0;n<Fh-1;n++)for(Bh[n]=r,e=0;e<1<<Ph[n];e++)zo[r++]=n;for(zo[r-1]=n,i=0,n=0;n<16;n++)for(Lc[n]=i,e=0;e<1<<Rc[n];e++)Bo[i++]=n;for(i>>=7;n<yi;n++)for(Lc[n]=i<<7,e=0;e<1<<Rc[n]-7;e++)Bo[256+i++]=n;for(t=0;t<=pn;t++)o[t]=0;for(e=0;e<=143;)ar[e*2+1]=8,e++,o[8]++;for(;e<=255;)ar[e*2+1]=9,e++,o[9]++;for(;e<=279;)ar[e*2+1]=7,e++,o[7]++;for(;e<=287;)ar[e*2+1]=8,e++,o[8]++;for(jO(ar,No+1,o),e=0;e<yi;e++)Lo[e*2+1]=5,Lo[e*2]=CO(e,5);PO=new mh(ar,Ph,$o+1,No,pn),qO=new mh(Lo,Rc,0,yi,pn),kO=new mh(new Array(0),xU,0,Dh,SU)},IO=e=>{let t;for(t=0;t<No;t++)e.dyn_ltree[t*2]=0;for(t=0;t<yi;t++)e.dyn_dtree[t*2]=0;for(t=0;t<Dh;t++)e.bl_tree[t*2]=0;e.dyn_ltree[Nh*2]=1,e.opt_len=e.static_len=0,e.sym_next=e.matches=0},RO=e=>{e.bi_valid>8?Ho(e,e.bi_buf):e.bi_valid>0&&(e.pending_buf[e.pending++]=e.bi_buf),e.bi_buf=0,e.bi_valid=0},DM=(e,t,r,n)=>{let i=t*2,o=r*2;return e[i]<e[o]||e[i]===e[o]&&n[t]<=n[r]},_h=(e,t,r)=>{let n=e.heap[r],i=r<<1;for(;i<=e.heap_len&&(i<e.heap_len&&DM(t,e.heap[i+1],e.heap[i],e.depth)&&i++,!DM(t,n,e.heap[i],e.depth));)e.heap[r]=e.heap[i],r=i,i<<=1;e.heap[r]=n},NM=(e,t,r)=>{let n,i,o=0,a,u;if(e.sym_next!==0)do n=e.pending_buf[e.sym_buf+o++]&255,n+=(e.pending_buf[e.sym_buf+o++]&255)<<8,i=e.pending_buf[e.sym_buf+o++],n===0?Dt(e,i,t):(a=zo[i],Dt(e,a+$o+1,t),u=Ph[a],u!==0&&(i-=Bh[a],We(e,i,u)),n--,a=TO(n),Dt(e,a,r),u=Rc[a],u!==0&&(n-=Lc[a],We(e,n,u)));while(o<e.sym_next);Dt(e,Nh,t)},qh=(e,t)=>{let r=t.dyn_tree,n=t.stat_desc.static_tree,i=t.stat_desc.has_stree,o=t.stat_desc.elems,a,u,p=-1,l;for(e.heap_len=0,e.heap_max=xO,a=0;a<o;a++)r[a*2]!==0?(e.heap[++e.heap_len]=p=a,e.depth[a]=0):r[a*2+1]=0;for(;e.heap_len<2;)l=e.heap[++e.heap_len]=p<2?++p:0,r[l*2]=1,e.depth[l]=0,e.opt_len--,i&&(e.static_len-=n[l*2+1]);for(t.max_code=p,a=e.heap_len>>1;a>=1;a--)_h(e,r,a);l=o;do 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i,o,a=0;e.level>0?(e.strm.data_type===2&&(e.strm.data_type=kU(e)),qh(e,e.l_desc),qh(e,e.d_desc),a=PU(e),i=e.opt_len+3+7>>>3,o=e.static_len+3+7>>>3,o<=i&&(i=o)):i=o=r+5,r+4<=i&&t!==-1?LO(e,t,r,n):e.strategy===4||o===i?(We(e,(SO<<1)+(n?1:0),3),NM(e,ar,Lo)):(We(e,(gU<<1)+(n?1:0),3),qU(e,e.l_desc.max_code+1,e.d_desc.max_code+1,a+1),NM(e,e.dyn_ltree,e.dyn_dtree)),IO(e),n&&RO(e)},IU=(e,t,r)=>(e.pending_buf[e.sym_buf+e.sym_next++]=t,e.pending_buf[e.sym_buf+e.sym_next++]=t>>8,e.pending_buf[e.sym_buf+e.sym_next++]=r,t===0?e.dyn_ltree[r*2]++:(e.matches++,t--,e.dyn_ltree[(zo[r]+$o+1)*2]++,e.dyn_dtree[TO(t)*2]++),e.sym_next===e.sym_end),RU=TU,LU=LO,FU=jU,DU=IU,NU=CU,BU={_tr_init:RU,_tr_stored_block:LU,_tr_flush_block:FU,_tr_tally:DU,_tr_align:NU},zU=(e,t,r,n)=>{let i=e&65535|0,o=e>>>16&65535|0,a=0;for(;r!==0;){a=r>2e3?2e3:r,r-=a;do i=i+t[n++]|0,o=o+i|0;while(--a);i%=65521,o%=65521}return i|o<<16|0},Vo=zU,HU=()=>{let e,t=[];for(var r=0;r<256;r++){e=r;for(var n=0;n<8;n++)e=e&1?3988292384^e>>>1:e>>>1;t[r]=e}return t},VU=new Uint32Array(HU()),UU=(e,t,r,n)=>{let i=VU,o=n+r;e^=-1;for(let a=n;a<o;a++)e=e>>>8^i[(e^t[a])&255];return e^-1},ge=UU,vn={2:"need dictionary",1:"stream end",0:"","-1":"file error","-2":"stream error","-3":"data error","-4":"insufficient memory","-5":"buffer error","-6":"incompatible version"},Ei={Z_NO_FLUSH:0,Z_PARTIAL_FLUSH:1,Z_SYNC_FLUSH:2,Z_FULL_FLUSH:3,Z_FINISH:4,Z_BLOCK:5,Z_TREES:6,Z_OK:0,Z_STREAM_END:1,Z_NEED_DICT:2,Z_ERRNO:-1,Z_STREAM_ERROR:-2,Z_DATA_ERROR:-3,Z_MEM_ERROR:-4,Z_BUF_ERROR:-5,Z_NO_COMPRESSION:0,Z_BEST_SPEED:1,Z_BEST_COMPRESSION:9,Z_DEFAULT_COMPRESSION:-1,Z_FILTERED:1,Z_HUFFMAN_ONLY:2,Z_RLE:3,Z_FIXED:4,Z_DEFAULT_STRATEGY:0,Z_BINARY:0,Z_TEXT:1,Z_UNKNOWN:2,Z_DEFLATED:8},{_tr_init:WU,_tr_stored_block:kh,_tr_flush_block:GU,_tr_tally:Nr,_tr_align:$U}=BU,{Z_NO_FLUSH:Br,Z_PARTIAL_FLUSH:YU,Z_FULL_FLUSH:XU,Z_FINISH:lt,Z_BLOCK:VM,Z_OK:Ee,Z_STREAM_END:UM,Z_STREAM_ERROR:Nt,Z_DATA_ERROR:ZU,Z_BUF_ERROR:bh,Z_DEFAULT_COMPRESSION:KU,Z_FILTERED:JU,Z_HUFFMAN_ONLY:kc,Z_RLE:QU,Z_FIXED:eW,Z_DEFAULT_STRATEGY:tW,Z_UNKNOWN:rW,Z_DEFLATED:Nc}=Ei,nW=9,iW=15,oW=8,aW=29,uW=256,Th=uW+1+aW,sW=30,lW=19,cW=2*Th+1,fW=15,V=3,Dr=258,Bt=Dr+V+1,dW=32,wi=42,zh=57,Ch=69,jh=73,Ih=91,Rh=103,hn=113,Io=666,Ie=1,Mi=2,_n=3,Oi=4,pW=3,mn=(e,t)=>(e.msg=vn[t],t),WM=e=>e*2-(e>4?9:0),Fr=e=>{let t=e.length;for(;--t>=0;)e[t]=0},hW=e=>{let t,r,n,i=e.w_size;t=e.hash_size,n=t;do r=e.head[--n],e.head[n]=r>=i?r-i:0;while(--t);t=i,n=t;do r=e.prev[--n],e.prev[n]=r>=i?r-i:0;while(--t)},mW=(e,t,r)=>(t<<e.hash_shift^r)&e.hash_mask,zr=mW,tt=e=>{let t=e.state,r=t.pending;r>e.avail_out&&(r=e.avail_out),r!==0&&(e.output.set(t.pending_buf.subarray(t.pending_out,t.pending_out+r),e.next_out),e.next_out+=r,t.pending_out+=r,e.total_out+=r,e.avail_out-=r,t.pending-=r,t.pending===0&&(t.pending_out=0))},rt=(e,t)=>{GU(e,e.block_start>=0?e.block_start:-1,e.strstart-e.block_start,t),e.block_start=e.strstart,tt(e.strm)},Y=(e,t)=>{e.pending_buf[e.pending++]=t},jo=(e,t)=>{e.pending_buf[e.pending++]=t>>>8&255,e.pending_buf[e.pending++]=t&255},Lh=(e,t,r,n)=>{let i=e.avail_in;return i>n&&(i=n),i===0?0:(e.avail_in-=i,t.set(e.input.subarray(e.next_in,e.next_in+i),r),e.state.wrap===1?e.adler=Vo(e.adler,t,i,r):e.state.wrap===2&&(e.adler=ge(e.adler,t,i,r)),e.next_in+=i,e.total_in+=i,i)},FO=(e,t)=>{let r=e.max_chain_length,n=e.strstart,i,o,a=e.prev_length,u=e.nice_match,p=e.strstart>e.w_size-Bt?e.strstart-(e.w_size-Bt):0,l=e.window,d=e.w_mask,s=e.prev,c=e.strstart+Dr,f=l[n+a-1],m=l[n+a];e.prev_length>=e.good_match&&(r>>=2),u>e.lookahead&&(u=e.lookahead);do if(i=t,!(l[i+a]!==m||l[i+a-1]!==f||l[i]!==l[n]||l[++i]!==l[n+1])){n+=2,i++;do;while(l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&l[++n]===l[++i]&&n<c);if(o=Dr-(c-n),n=c-Dr,o>a){if(e.match_start=t,a=o,o>=u)break;f=l[n+a-1],m=l[n+a]}}while((t=s[t&d])>p&&--r!==0);return a<=e.lookahead?a:e.lookahead},Si=e=>{let t=e.w_size,r,n,i;do{if(n=e.window_size-e.lookahead-e.strstart,e.strstart>=t+(t-Bt)&&(e.window.set(e.window.subarray(t,t+t-n),0),e.match_start-=t,e.strstart-=t,e.block_start-=t,e.insert>e.strstart&&(e.insert=e.strstart),hW(e),n+=t),e.strm.avail_in===0)break;if(r=Lh(e.strm,e.window,e.strstart+e.lookahead,n),e.lookahead+=r,e.lookahead+e.insert>=V)for(i=e.strstart-e.insert,e.ins_h=e.window[i],e.ins_h=zr(e,e.ins_h,e.window[i+1]);e.insert&&(e.ins_h=zr(e,e.ins_h,e.window[i+V-1]),e.prev[i&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=i,i++,e.insert--,!(e.lookahead+e.insert<V)););}while(e.lookahead<Bt&&e.strm.avail_in!==0)},DO=(e,t)=>{let r=e.pending_buf_size-5>e.w_size?e.w_size:e.pending_buf_size-5,n,i,o,a=0,u=e.strm.avail_in;do{if(n=65535,o=e.bi_valid+42>>3,e.strm.avail_out<o||(o=e.strm.avail_out-o,i=e.strstart-e.block_start,n>i+e.strm.avail_in&&(n=i+e.strm.avail_in),n>o&&(n=o),n<r&&(n===0&&t!==lt||t===Br||n!==i+e.strm.avail_in)))break;a=t===lt&&n===i+e.strm.avail_in?1:0,kh(e,0,0,a),e.pending_buf[e.pending-4]=n,e.pending_buf[e.pending-3]=n>>8,e.pending_buf[e.pending-2]=~n,e.pending_buf[e.pending-1]=~n>>8,tt(e.strm),i&&(i>n&&(i=n),e.strm.output.set(e.window.subarray(e.block_start,e.block_start+i),e.strm.next_out),e.strm.next_out+=i,e.strm.avail_out-=i,e.strm.total_out+=i,e.block_start+=i,n-=i),n&&(Lh(e.strm,e.strm.output,e.strm.next_out,n),e.strm.next_out+=n,e.strm.avail_out-=n,e.strm.total_out+=n)}while(a===0);return u-=e.strm.avail_in,u&&(u>=e.w_size?(e.matches=2,e.window.set(e.strm.input.subarray(e.strm.next_in-e.w_size,e.strm.next_in),0),e.strstart=e.w_size,e.insert=e.strstart):(e.window_size-e.strstart<=u&&(e.strstart-=e.w_size,e.window.set(e.window.subarray(e.w_size,e.w_size+e.strstart),0),e.matches<2&&e.matches++,e.insert>e.strstart&&(e.insert=e.strstart)),e.window.set(e.strm.input.subarray(e.strm.next_in-u,e.strm.next_in),e.strstart),e.strstart+=u,e.insert+=u>e.w_size-e.insert?e.w_size-e.insert:u),e.block_start=e.strstart),e.high_water<e.strstart&&(e.high_water=e.strstart),a?Oi:t!==Br&&t!==lt&&e.strm.avail_in===0&&e.strstart===e.block_start?Mi:(o=e.window_size-e.strstart,e.strm.avail_in>o&&e.block_start>=e.w_size&&(e.block_start-=e.w_size,e.strstart-=e.w_size,e.window.set(e.window.subarray(e.w_size,e.w_size+e.strstart),0),e.matches<2&&e.matches++,o+=e.w_size,e.insert>e.strstart&&(e.insert=e.strstart)),o>e.strm.avail_in&&(o=e.strm.avail_in),o&&(Lh(e.strm,e.window,e.strstart,o),e.strstart+=o,e.insert+=o>e.w_size-e.insert?e.w_size-e.insert:o),e.high_water<e.strstart&&(e.high_water=e.strstart),o=e.bi_valid+42>>3,o=e.pending_buf_size-o>65535?65535:e.pending_buf_size-o,r=o>e.w_size?e.w_size:o,i=e.strstart-e.block_start,(i>=r||(i||t===lt)&&t!==Br&&e.strm.avail_in===0&&i<=o)&&(n=i>o?o:i,a=t===lt&&e.strm.avail_in===0&&n===i?1:0,kh(e,e.block_start,n,a),e.block_start+=n,tt(e.strm)),a?_n:Ie)},gh=(e,t)=>{let r,n;for(;;){if(e.lookahead<Bt){if(Si(e),e.lookahead<Bt&&t===Br)return Ie;if(e.lookahead===0)break}if(r=0,e.lookahead>=V&&(e.ins_h=zr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),r!==0&&e.strstart-r<=e.w_size-Bt&&(e.match_length=FO(e,r)),e.match_length>=V)if(n=Nr(e,e.strstart-e.match_start,e.match_length-V),e.lookahead-=e.match_length,e.match_length<=e.max_lazy_match&&e.lookahead>=V){e.match_length--;do e.strstart++,e.ins_h=zr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart;while(--e.match_length!==0);e.strstart++}else e.strstart+=e.match_length,e.match_length=0,e.ins_h=e.window[e.strstart],e.ins_h=zr(e,e.ins_h,e.window[e.strstart+1]);else n=Nr(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++;if(n&&(rt(e,!1),e.strm.avail_out===0))return Ie}return e.insert=e.strstart<V-1?e.strstart:V-1,t===lt?(rt(e,!0),e.strm.avail_out===0?_n:Oi):e.sym_next&&(rt(e,!1),e.strm.avail_out===0)?Ie:Mi},bi=(e,t)=>{let r,n,i;for(;;){if(e.lookahead<Bt){if(Si(e),e.lookahead<Bt&&t===Br)return Ie;if(e.lookahead===0)break}if(r=0,e.lookahead>=V&&(e.ins_h=zr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),e.prev_length=e.match_length,e.prev_match=e.match_start,e.match_length=V-1,r!==0&&e.prev_length<e.max_lazy_match&&e.strstart-r<=e.w_size-Bt&&(e.match_length=FO(e,r),e.match_length<=5&&(e.strategy===JU||e.match_length===V&&e.strstart-e.match_start>4096)&&(e.match_length=V-1)),e.prev_length>=V&&e.match_length<=e.prev_length){i=e.strstart+e.lookahead-V,n=Nr(e,e.strstart-1-e.prev_match,e.prev_length-V),e.lookahead-=e.prev_length-1,e.prev_length-=2;do++e.strstart<=i&&(e.ins_h=zr(e,e.ins_h,e.window[e.strstart+V-1]),r=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart);while(--e.prev_length!==0);if(e.match_available=0,e.match_length=V-1,e.strstart++,n&&(rt(e,!1),e.strm.avail_out===0))return Ie}else if(e.match_available){if(n=Nr(e,0,e.window[e.strstart-1]),n&&rt(e,!1),e.strstart++,e.lookahead--,e.strm.avail_out===0)return Ie}else e.match_available=1,e.strstart++,e.lookahead--}return e.match_available&&(n=Nr(e,0,e.window[e.strstart-1]),e.match_available=0),e.insert=e.strstart<V-1?e.strstart:V-1,t===lt?(rt(e,!0),e.strm.avail_out===0?_n:Oi):e.sym_next&&(rt(e,!1),e.strm.avail_out===0)?Ie:Mi},vW=(e,t)=>{let r,n,i,o,a=e.window;for(;;){if(e.lookahead<=Dr){if(Si(e),e.lookahead<=Dr&&t===Br)return Ie;if(e.lookahead===0)break}if(e.match_length=0,e.lookahead>=V&&e.strstart>0&&(i=e.strstart-1,n=a[i],n===a[++i]&&n===a[++i]&&n===a[++i])){o=e.strstart+Dr;do;while(n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&n===a[++i]&&i<o);e.match_length=Dr-(o-i),e.match_length>e.lookahead&&(e.match_length=e.lookahead)}if(e.match_length>=V?(r=Nr(e,1,e.match_length-V),e.lookahead-=e.match_length,e.strstart+=e.match_length,e.match_length=0):(r=Nr(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++),r&&(rt(e,!1),e.strm.avail_out===0))return Ie}return e.insert=0,t===lt?(rt(e,!0),e.strm.avail_out===0?_n:Oi):e.sym_next&&(rt(e,!1),e.strm.avail_out===0)?Ie:Mi},_W=(e,t)=>{let r;for(;;){if(e.lookahead===0&&(Si(e),e.lookahead===0)){if(t===Br)return Ie;break}if(e.match_length=0,r=Nr(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++,r&&(rt(e,!1),e.strm.avail_out===0))return Ie}return e.insert=0,t===lt?(rt(e,!0),e.strm.avail_out===0?_n:Oi):e.sym_next&&(rt(e,!1),e.strm.avail_out===0)?Ie:Mi};function Ft(e,t,r,n,i){this.good_length=e,this.max_lazy=t,this.nice_length=r,this.max_chain=n,this.func=i}var Ro=[new Ft(0,0,0,0,DO),new Ft(4,4,8,4,gh),new Ft(4,5,16,8,gh),new Ft(4,6,32,32,gh),new Ft(4,4,16,16,bi),new Ft(8,16,32,32,bi),new Ft(8,16,128,128,bi),new Ft(8,32,128,256,bi),new Ft(32,128,258,1024,bi),new Ft(32,258,258,4096,bi)],bW=e=>{e.window_size=2*e.w_size,Fr(e.head),e.max_lazy_match=Ro[e.level].max_lazy,e.good_match=Ro[e.level].good_length,e.nice_match=Ro[e.level].nice_length,e.max_chain_length=Ro[e.level].max_chain,e.strstart=0,e.block_start=0,e.lookahead=0,e.insert=0,e.match_length=e.prev_length=V-1,e.match_available=0,e.ins_h=0};function gW(){this.strm=null,this.status=0,this.pending_buf=null,this.pending_buf_size=0,this.pending_out=0,this.pending=0,this.wrap=0,this.gzhead=null,this.gzindex=0,this.method=Nc,this.last_flush=-1,this.w_size=0,this.w_bits=0,this.w_mask=0,this.window=null,this.window_size=0,this.prev=null,this.head=null,this.ins_h=0,this.hash_size=0,this.hash_bits=0,this.hash_mask=0,this.hash_shift=0,this.block_start=0,this.match_length=0,this.prev_match=0,this.match_available=0,this.strstart=0,this.match_start=0,this.lookahead=0,this.prev_length=0,this.max_chain_length=0,this.max_lazy_match=0,this.level=0,this.strategy=0,this.good_match=0,this.nice_match=0,this.dyn_ltree=new Uint16Array(cW*2),this.dyn_dtree=new Uint16Array((2*sW+1)*2),this.bl_tree=new Uint16Array((2*lW+1)*2),Fr(this.dyn_ltree),Fr(this.dyn_dtree),Fr(this.bl_tree),this.l_desc=null,this.d_desc=null,this.bl_desc=null,this.bl_count=new Uint16Array(fW+1),this.heap=new 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Uint8Array([16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78]),sG=new Uint16Array([1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0]),lG=new Uint8Array([16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64]),cG=(e,t,r,n,i,o,a,u)=>{let p=u.bits,l=0,d=0,s=0,c=0,f=0,m=0,v=0,h=0,_=0,y=0,w,S,E,M,A,q=null,O,P=new Uint16Array(gi+1),k=new Uint16Array(gi+1),I=null,$,N,ie;for(l=0;l<=gi;l++)P[l]=0;for(d=0;d<n;d++)P[t[r+d]]++;for(f=p,c=gi;c>=1&&P[c]===0;c--);if(f>c&&(f=c),c===0)return 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y!==0&&(i[A+y]=l-v<<24|64<<16|0),u.bits=f,0},Do=cG,fG=0,WO=1,GO=2,{Z_FINISH:ZM,Z_BLOCK:dG,Z_TREES:Cc,Z_OK:bn,Z_STREAM_END:pG,Z_NEED_DICT:hG,Z_STREAM_ERROR:ct,Z_DATA_ERROR:$O,Z_MEM_ERROR:YO,Z_BUF_ERROR:mG,Z_DEFLATED:KM}=Ei,zc=16180,JM=16181,QM=16182,eO=16183,tO=16184,rO=16185,nO=16186,iO=16187,oO=16188,aO=16189,Dc=16190,or=16191,wh=16192,uO=16193,Sh=16194,sO=16195,lO=16196,cO=16197,fO=16198,jc=16199,Ic=16200,dO=16201,pO=16202,hO=16203,mO=16204,vO=16205,xh=16206,_O=16207,bO=16208,ne=16209,XO=16210,ZO=16211,vG=852,_G=592,bG=15,gG=bG,gO=e=>(e>>>24&255)+(e>>>8&65280)+((e&65280)<<8)+((e&255)<<24);function yG(){this.strm=null,this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new Uint16Array(320),this.work=new Uint16Array(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}var gn=e=>{if(!e)return 1;let t=e.state;return!t||t.strm!==e||t.mode<zc||t.mode>ZO?1:0},KO=e=>{if(gn(e))return ct;let t=e.state;return e.total_in=e.total_out=t.total=0,e.msg="",t.wrap&&(e.adler=t.wrap&1),t.mode=zc,t.last=0,t.havedict=0,t.flags=-1,t.dmax=32768,t.head=null,t.hold=0,t.bits=0,t.lencode=t.lendyn=new Int32Array(vG),t.distcode=t.distdyn=new Int32Array(_G),t.sane=1,t.back=-1,bn},JO=e=>{if(gn(e))return ct;let t=e.state;return t.wsize=0,t.whave=0,t.wnext=0,KO(e)},QO=(e,t)=>{let r;if(gn(e))return ct;let n=e.state;return t<0?(r=0,t=-t):(r=(t>>4)+5,t<48&&(t&=15)),t&&(t<8||t>15)?ct:(n.window!==null&&n.wbits!==t&&(n.window=null),n.wrap=r,n.wbits=t,JO(e))},e2=(e,t)=>{if(!e)return ct;let r=new yG;e.state=r,r.strm=e,r.window=null,r.mode=zc;let n=QO(e,t);return n!==bn&&(e.state=null),n},wG=e=>e2(e,gG),yO=!0,Eh,Mh,SG=e=>{if(yO){Eh=new Int32Array(512),Mh=new Int32Array(32);let t=0;for(;t<144;)e.lens[t++]=8;for(;t<256;)e.lens[t++]=9;for(;t<280;)e.lens[t++]=7;for(;t<288;)e.lens[t++]=8;for(Do(WO,e.lens,0,288,Eh,0,e.work,{bits:9}),t=0;t<32;)e.lens[t++]=5;Do(GO,e.lens,0,32,Mh,0,e.work,{bits:5}),yO=!1}e.lencode=Eh,e.lenbits=9,e.distcode=Mh,e.distbits=5},t2=(e,t,r,n)=>{let i,o=e.state;return o.window===null&&(o.wsize=1<<o.wbits,o.wnext=0,o.whave=0,o.window=new Uint8Array(o.wsize)),n>=o.wsize?(o.window.set(t.subarray(r-o.wsize,r),0),o.wnext=0,o.whave=o.wsize):(i=o.wsize-o.wnext,i>n&&(i=n),o.window.set(t.subarray(r-n,r-n+i),o.wnext),n-=i,n?(o.window.set(t.subarray(r-n,r),0),o.wnext=n,o.whave=o.wsize):(o.wnext+=i,o.wnext===o.wsize&&(o.wnext=0),o.whave<o.wsize&&(o.whave+=i))),0},xG=(e,t)=>{let r,n,i,o,a,u,p,l,d,s,c,f,m,v,h=0,_,y,w,S,E,M,A,q,O=new Uint8Array(4),P,k,I=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]);if(gn(e)||!e.output||!e.input&&e.avail_in!==0)return ct;r=e.state,r.mode===or&&(r.mode=wh),a=e.next_out,i=e.output,p=e.avail_out,o=e.next_in,n=e.input,u=e.avail_in,l=r.hold,d=r.bits,s=u,c=p,q=bn;e:for(;;)switch(r.mode){case zc:if(r.wrap===0){r.mode=wh;break}for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&2&&l===35615){r.wbits===0&&(r.wbits=15),r.check=0,O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0),l=0,d=0,r.mode=JM;break}if(r.head&&(r.head.done=!1),!(r.wrap&1)||(((l&255)<<8)+(l>>8))%31){e.msg="incorrect header check",r.mode=ne;break}if((l&15)!==KM){e.msg="unknown compression method",r.mode=ne;break}if(l>>>=4,d-=4,A=(l&15)+8,r.wbits===0&&(r.wbits=A),A>15||A>r.wbits){e.msg="invalid window size",r.mode=ne;break}r.dmax=1<<r.wbits,r.flags=0,e.adler=r.check=1,r.mode=l&512?aO:or,l=0,d=0;break;case JM:for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.flags=l,(r.flags&255)!==KM){e.msg="unknown compression method",r.mode=ne;break}if(r.flags&57344){e.msg="unknown header flags set",r.mode=ne;break}r.head&&(r.head.text=l>>8&1),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0)),l=0,d=0,r.mode=QM;case QM:for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.head&&(r.head.time=l),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,O[2]=l>>>16&255,O[3]=l>>>24&255,r.check=ge(r.check,O,4,0)),l=0,d=0,r.mode=eO;case eO:for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.head&&(r.head.xflags=l&255,r.head.os=l>>8),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0)),l=0,d=0,r.mode=tO;case tO:if(r.flags&1024){for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.length=l,r.head&&(r.head.extra_len=l),r.flags&512&&r.wrap&4&&(O[0]=l&255,O[1]=l>>>8&255,r.check=ge(r.check,O,2,0)),l=0,d=0}else r.head&&(r.head.extra=null);r.mode=rO;case rO:if(r.flags&1024&&(f=r.length,f>u&&(f=u),f&&(r.head&&(A=r.head.extra_len-r.length,r.head.extra||(r.head.extra=new Uint8Array(r.head.extra_len)),r.head.extra.set(n.subarray(o,o+f),A)),r.flags&512&&r.wrap&4&&(r.check=ge(r.check,n,f,o)),u-=f,o+=f,r.length-=f),r.length))break e;r.length=0,r.mode=nO;case nO:if(r.flags&2048){if(u===0)break e;f=0;do A=n[o+f++],r.head&&A&&r.length<65536&&(r.head.name+=String.fromCharCode(A));while(A&&f<u);if(r.flags&512&&r.wrap&4&&(r.check=ge(r.check,n,f,o)),u-=f,o+=f,A)break e}else r.head&&(r.head.name=null);r.length=0,r.mode=iO;case iO:if(r.flags&4096){if(u===0)break e;f=0;do A=n[o+f++],r.head&&A&&r.length<65536&&(r.head.comment+=String.fromCharCode(A));while(A&&f<u);if(r.flags&512&&r.wrap&4&&(r.check=ge(r.check,n,f,o)),u-=f,o+=f,A)break e}else r.head&&(r.head.comment=null);r.mode=oO;case oO:if(r.flags&512){for(;d<16;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&4&&l!==(r.check&65535)){e.msg="header crc mismatch",r.mode=ne;break}l=0,d=0}r.head&&(r.head.hcrc=r.flags>>9&1,r.head.done=!0),e.adler=r.check=0,r.mode=or;break;case aO:for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}e.adler=r.check=gO(l),l=0,d=0,r.mode=Dc;case Dc:if(r.havedict===0)return e.next_out=a,e.avail_out=p,e.next_in=o,e.avail_in=u,r.hold=l,r.bits=d,hG;e.adler=r.check=1,r.mode=or;case or:if(t===dG||t===Cc)break e;case wh:if(r.last){l>>>=d&7,d-=d&7,r.mode=xh;break}for(;d<3;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}switch(r.last=l&1,l>>>=1,d-=1,l&3){case 0:r.mode=uO;break;case 1:if(SG(r),r.mode=jc,t===Cc){l>>>=2,d-=2;break e}break;case 2:r.mode=lO;break;case 3:e.msg="invalid block type",r.mode=ne}l>>>=2,d-=2;break;case uO:for(l>>>=d&7,d-=d&7;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if((l&65535)!==(l>>>16^65535)){e.msg="invalid stored block lengths",r.mode=ne;break}if(r.length=l&65535,l=0,d=0,r.mode=Sh,t===Cc)break e;case Sh:r.mode=sO;case sO:if(f=r.length,f){if(f>u&&(f=u),f>p&&(f=p),f===0)break e;i.set(n.subarray(o,o+f),a),u-=f,o+=f,p-=f,a+=f,r.length-=f;break}r.mode=or;break;case lO:for(;d<14;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.nlen=(l&31)+257,l>>>=5,d-=5,r.ndist=(l&31)+1,l>>>=5,d-=5,r.ncode=(l&15)+4,l>>>=4,d-=4,r.nlen>286||r.ndist>30){e.msg="too many length or distance symbols",r.mode=ne;break}r.have=0,r.mode=cO;case cO:for(;r.have<r.ncode;){for(;d<3;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.lens[I[r.have++]]=l&7,l>>>=3,d-=3}for(;r.have<19;)r.lens[I[r.have++]]=0;if(r.lencode=r.lendyn,r.lenbits=7,P={bits:r.lenbits},q=Do(fG,r.lens,0,19,r.lencode,0,r.work,P),r.lenbits=P.bits,q){e.msg="invalid code lengths set",r.mode=ne;break}r.have=0,r.mode=fO;case fO:for(;r.have<r.nlen+r.ndist;){for(;h=r.lencode[l&(1<<r.lenbits)-1],_=h>>>24,y=h>>>16&255,w=h&65535,!(_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(w<16)l>>>=_,d-=_,r.lens[r.have++]=w;else{if(w===16){for(k=_+2;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(l>>>=_,d-=_,r.have===0){e.msg="invalid bit length repeat",r.mode=ne;break}A=r.lens[r.have-1],f=3+(l&3),l>>>=2,d-=2}else if(w===17){for(k=_+3;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=_,d-=_,A=0,f=3+(l&7),l>>>=3,d-=3}else{for(k=_+7;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=_,d-=_,A=0,f=11+(l&127),l>>>=7,d-=7}if(r.have+f>r.nlen+r.ndist){e.msg="invalid bit length repeat",r.mode=ne;break}for(;f--;)r.lens[r.have++]=A}}if(r.mode===ne)break;if(r.lens[256]===0){e.msg="invalid code -- missing end-of-block",r.mode=ne;break}if(r.lenbits=9,P={bits:r.lenbits},q=Do(WO,r.lens,0,r.nlen,r.lencode,0,r.work,P),r.lenbits=P.bits,q){e.msg="invalid literal/lengths set",r.mode=ne;break}if(r.distbits=6,r.distcode=r.distdyn,P={bits:r.distbits},q=Do(GO,r.lens,r.nlen,r.ndist,r.distcode,0,r.work,P),r.distbits=P.bits,q){e.msg="invalid distances set",r.mode=ne;break}if(r.mode=jc,t===Cc)break e;case jc:r.mode=Ic;case Ic:if(u>=6&&p>=258){e.next_out=a,e.avail_out=p,e.next_in=o,e.avail_in=u,r.hold=l,r.bits=d,oG(e,c),a=e.next_out,i=e.output,p=e.avail_out,o=e.next_in,n=e.input,u=e.avail_in,l=r.hold,d=r.bits,r.mode===or&&(r.back=-1);break}for(r.back=0;h=r.lencode[l&(1<<r.lenbits)-1],_=h>>>24,y=h>>>16&255,w=h&65535,!(_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(y&&!(y&240)){for(S=_,E=y,M=w;h=r.lencode[M+((l&(1<<S+E)-1)>>S)],_=h>>>24,y=h>>>16&255,w=h&65535,!(S+_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=S,d-=S,r.back+=S}if(l>>>=_,d-=_,r.back+=_,r.length=w,y===0){r.mode=vO;break}if(y&32){r.back=-1,r.mode=or;break}if(y&64){e.msg="invalid literal/length code",r.mode=ne;break}r.extra=y&15,r.mode=dO;case dO:if(r.extra){for(k=r.extra;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.length+=l&(1<<r.extra)-1,l>>>=r.extra,d-=r.extra,r.back+=r.extra}r.was=r.length,r.mode=pO;case pO:for(;h=r.distcode[l&(1<<r.distbits)-1],_=h>>>24,y=h>>>16&255,w=h&65535,!(_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(!(y&240)){for(S=_,E=y,M=w;h=r.distcode[M+((l&(1<<S+E)-1)>>S)],_=h>>>24,y=h>>>16&255,w=h&65535,!(S+_<=d);){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}l>>>=S,d-=S,r.back+=S}if(l>>>=_,d-=_,r.back+=_,y&64){e.msg="invalid distance code",r.mode=ne;break}r.offset=w,r.extra=y&15,r.mode=hO;case hO:if(r.extra){for(k=r.extra;d<k;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}r.offset+=l&(1<<r.extra)-1,l>>>=r.extra,d-=r.extra,r.back+=r.extra}if(r.offset>r.dmax){e.msg="invalid distance too far back",r.mode=ne;break}r.mode=mO;case mO:if(p===0)break e;if(f=c-p,r.offset>f){if(f=r.offset-f,f>r.whave&&r.sane){e.msg="invalid distance too far back",r.mode=ne;break}f>r.wnext?(f-=r.wnext,m=r.wsize-f):m=r.wnext-f,f>r.length&&(f=r.length),v=r.window}else v=i,m=a-r.offset,f=r.length;f>p&&(f=p),p-=f,r.length-=f;do i[a++]=v[m++];while(--f);r.length===0&&(r.mode=Ic);break;case vO:if(p===0)break e;i[a++]=r.length,p--,r.mode=Ic;break;case xh:if(r.wrap){for(;d<32;){if(u===0)break e;u--,l|=n[o++]<<d,d+=8}if(c-=p,e.total_out+=c,r.total+=c,r.wrap&4&&c&&(e.adler=r.check=r.flags?ge(r.check,i,c,a-c):Vo(r.check,i,c,a-c)),c=p,r.wrap&4&&(r.flags?l:gO(l))!==r.check){e.msg="incorrect data check",r.mode=ne;break}l=0,d=0}r.mode=_O;case _O:if(r.wrap&&r.flags){for(;d<32;){if(u===0)break e;u--,l+=n[o++]<<d,d+=8}if(r.wrap&4&&l!==(r.total&4294967295)){e.msg="incorrect length check",r.mode=ne;break}l=0,d=0}r.mode=bO;case bO:q=pG;break e;case ne:q=$O;break e;case XO:return YO;case ZO:default:return ct}return e.next_out=a,e.avail_out=p,e.next_in=o,e.avail_in=u,r.hold=l,r.bits=d,(r.wsize||c!==e.avail_out&&r.mode<ne&&(r.mode<xh||t!==ZM))&&t2(e,e.output,e.next_out,c-e.avail_out),s-=e.avail_in,c-=e.avail_out,e.total_in+=s,e.total_out+=c,r.total+=c,r.wrap&4&&c&&(e.adler=r.check=r.flags?ge(r.check,i,c,e.next_out-c):Vo(r.check,i,c,e.next_out-c)),e.data_type=r.bits+(r.last?64:0)+(r.mode===or?128:0)+(r.mode===jc||r.mode===Sh?256:0),(s===0&&c===0||t===ZM)&&q===bn&&(q=mG),q},EG=e=>{if(gn(e))return ct;let t=e.state;return t.window&&(t.window=null),e.state=null,bn},MG=(e,t)=>{if(gn(e))return ct;let r=e.state;return r.wrap&2?(r.head=t,t.done=!1,bn):ct},OG=(e,t)=>{let r=t.length,n,i,o;return gn(e)||(n=e.state,n.wrap!==0&&n.mode!==Dc)?ct:n.mode===Dc&&(i=1,i=Vo(i,t,r,0),i!==n.check)?$O:(o=t2(e,t,r,r),o?(n.mode=XO,YO):(n.havedict=1,bn))},AG=JO,PG=QO,qG=KO,kG=wG,TG=e2,CG=xG,jG=EG,IG=MG,RG=OG,LG="pako inflate (from Nodeca project)",ur={inflateReset:AG,inflateReset2:PG,inflateResetKeep:qG,inflateInit:kG,inflateInit2:TG,inflate:CG,inflateEnd:jG,inflateGetHeader:IG,inflateSetDictionary:RG,inflateInfo:LG};function FG(){this.text=0,this.time=0,this.xflags=0,this.os=0,this.extra=null,this.extra_len=0,this.name="",this.comment="",this.hcrc=0,this.done=!1}var DG=FG,r2=Object.prototype.toString,{Z_NO_FLUSH:NG,Z_FINISH:BG,Z_OK:Go,Z_STREAM_END:Oh,Z_NEED_DICT:Ah,Z_STREAM_ERROR:zG,Z_DATA_ERROR:wO,Z_MEM_ERROR:HG}=Ei;function Zo(e){this.options=Bc.assign({chunkSize:1024*64,windowBits:15,to:""},e||{});let 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r?Gh.default.createElement(o$,{model:t}):null}),o$=(0,$h.observer)(function({model:t}){let{classes:r}=Uc(),n=(0,Yh.getSession)(t);if(n.views.some(i=>i.type==="MsaView")){let{hovered:i}=n,{offsetPx:o}=t,{coord:a,refName:u}=i.hoverPosition,p=t.bpToPx({refName:u,coord:a-1}),l=t.bpToPx({refName:u,coord:a});if(p&&l){let d=Math.max(Math.abs(l.offsetPx-p.offsetPx),4),s=Math.min(p.offsetPx,l.offsetPx)-o;return Gh.default.createElement("div",{className:r.highlight,style:{left:s,width:d}})}}return null}),m2=i$;var a$=(0,v2.observer)(function({model:t}){return Ko.default.createElement(Ko.default.Fragment,null,Ko.default.createElement(h2,{model:t}),Ko.default.createElement(m2,{model:t}))}),_2=a$;function Xh(e){e.addToExtensionPoint("LinearGenomeView-TracksContainerComponent",(t=[],{model:r})=>[...t,b2.default.createElement(_2,{key:"highlight_protein_viewer_msaview",model:r})])}var Gc=class extends g2.default{constructor(){super(...arguments);this.name="MsaViewPlugin";this.version=im}install(r){sh(r),Wh(r),Xh(r)}configure(r){(0,y2.isAbstractMenuManager)(r.rootModel)&&r.rootModel.appendToSubMenu(["Add"],{label:"Multiple sequence alignment view",icon:w2.default,onClick:n=>{n.addView("MsaView",{})}})}};return A2(u$);})();
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