jbrowse-plugin-graphgenomeviewer 7.3.0 → 7.3.1

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "jbrowse-plugin-graphgenomeviewer",
-  "version": "7.3.0",
+  "version": "7.3.1",
   "description": "JBrowse 2 graph genome (pangenome) view: rGFA reference-anchored layouts, the Bandage force-directed engine, and haplotype lanes read from a gbz-base database",
   "license": "GPL-3.0-or-later",
   "repository": {
@@ -32,7 +32,7 @@
     "@jbrowse/core": "5.0.0-beta.11",
     "@jbrowse/display-kit": "5.0.0-beta.11",
     "@jbrowse/display-ui": "5.0.0-beta.11",
-    "@jbrowse/graph-walks": "^2.1.0",
+    "@jbrowse/graph-walks": "^3.0.0",
     "@jbrowse/render-core": "5.0.0-beta.11",
     "@jbrowse/synteny-core": "5.0.0-beta.11"
   },

package/src/RgfaTabixAdapter/configSchema.ts

@@ -30,8 +30,8 @@ import type { Instance } from '@jbrowse/mobx-state-tree'
  * `walksUri` takes the prefix of a walk file in place of `uri`, and resolves
  * `<walksUri>.walks.bed.gz` and its `.tbi`. `gfa-to-tabix --walks -o <prefix>`
  * writes one per reference sample, so a track names one as
- * `<prefix>.<sample>`. The adapter reads walk format 3, which gfa-to-tabix
- * writes from 1.1, through @jbrowse/graph-walks. Such a graph's cut carries
+ * `<prefix>.<sample>`. The adapter reads walk format 4, which gfa-to-tabix
+ * writes from 1.2, through @jbrowse/graph-walks. Such a graph's cut carries
  * the haplotypes' walks, and `defaultHaplotypes` names the ones it is cut for
  * until the user picks others.
  *
@@ -48,7 +48,7 @@ import type { Instance } from '@jbrowse/mobx-state-tree'
  * ```js
  * {
  *   type: 'RgfaTabixAdapter',
- *   walksUri: 'https://example.org/hprc-v2.1-mc-grch38.GRCh38',
+ *   walksUri: 'https://jbrowse.org/demos/hprc/hprc-v2.1-mc-grch38-f4.GRCh38',
  *   assemblyNameToPanSN: { hg38: 'GRCh38' },
  *   defaultHaplotypes: ['HG002', 'HG00733', 'HG02257', 'NA19240'],
  * }
@@ -152,7 +152,7 @@ const RgfaTabixAdapter = ConfigurationSchema(
     ),
     /**
      * #slot
-     * a `gfa-to-tabix --walks` file in walk format 3: per reference chunk,
+     * a `gfa-to-tabix --walks` file in walk format 4: per reference chunk,
      * the reference's path, the ways haplotypes leave it and each haplotype's
      * piece. Unset means the graph has no walks.
      */

package/src/RgfaTabixAdapter/walkFiles.test.ts

@@ -17,9 +17,9 @@ import type { WalkCut } from './walkCut.ts'
 import type { GraphTables } from '@jbrowse/bandage-core/gfa/graphTables'
 
 // chr22 of HPRC v2.1 at base level, one walk file per reference in walk
-// format 3, built under ~/work/scratch/walks-20261008/f3. Skipped where the
+// format 4, built under ~/work/scratch/walks-20261008/f4. Skipped where the
 // files are absent.
-const chr22 = '/home/cdiesh/work/scratch/walks-20261008/f3/chr22'
+const chr22 = '/home/cdiesh/work/scratch/walks-20261008/f4/chr22'
 const present = ['GRCh38', 'CHM13'].every(sample =>
   existsSync(`${chr22}.${sample}.walks.bed.gz`),
 )
@@ -34,27 +34,27 @@ const fixture = (name: string) =>
 //   W HG002   1 chr1 >1>2>7>4>5>6   7 replaces 3
 //   W HG002   2 chr1 >1>2>3>4>8>6   8 replaces 5
 //   W HG00097 1 chr1 >1>2>3>4>5>6
-const headerPrefix = fixture('walks3_header')
+const headerPrefix = fixture('walks4_header')
 
-// walks3_header's walks with the reference named as pggb names a P-line,
+// walks4_header's walks with the reference named as pggb names a P-line,
 // GRCh38#chr1
-const twoPartPrefix = fixture('walks3_twopart')
+const twoPartPrefix = fixture('walks4_twopart')
 
 // An unchopped graph, node 1 spanning 0-2600 and filed under chunk 0 alone:
 //   W GRCh38 0 chr1 >1>2>4
 //   W HG002  1 chr1 >1>3>4   3 replaces 2
-const maxNodePrefix = fixture('walks3_maxnode')
+const maxNodePrefix = fixture('walks4_maxnode')
 
 // Twelve 500 bp reference nodes over chr1:0-6000 in one 10 kb chunk:
 //   W GRCh38  0 chr1 >1>2>3>4>5>6>7>8>9>10>11>12
 //   W HG002   1 chr1 >1>2>3>20>21>9>10>11>12   20 and 21, 2 kb each, replace 4-8
 //   W HG002   2 chr1 >1>2>3>4>5>6>7>8>9>10>11>12
 //   W HG003   1 chr1 >1>2>3>22                 the contig ends on 22, 300 bp
-const rejoinPrefix = fixture('walks3_rejoin')
+const rejoinPrefix = fixture('walks4_rejoin')
 
 // The same graph in 1 kb chunks, whose rows name the chunks their path goes on
 // in: HG002#1 leaves chunk 1000 for 20 and 21 and rejoins at 9, in chunk 4000
-const followPrefix = fixture('walks3_follow')
+const followPrefix = fixture('walks4_follow')
 
 function makeAdapter(prefix: string, slots = {}) {
   const local = (path: string) => ({
@@ -215,7 +215,7 @@ test('a cut for some haplotypes keeps a reference walk named without a haplotype
 
 test('a format 1 walk file is refused, with what to rebuild it with', async () => {
   const cut = makeAdapter(fixture('walks1_header')).getSubgraph(chr1(0, 600))
-  await expect(cut).rejects.toThrow(/rebuild it with gfa-to-tabix 1.1/)
+  await expect(cut).rejects.toThrow(/rebuild it with gfa-to-tabix 1.2/)
 })
 
 test('a cut over walkByteBudget reads no row', async () => {

package/src/WalkTabixSyntenyAdapter/WalkTabixSyntenyAdapter.test.ts

@@ -34,7 +34,7 @@ const fixture = (name: string) =>
 
 function makeAdapter(
   slots: Record<string, unknown> = {},
-  name = 'walks3_header',
+  name = 'walks4_header',
 ) {
   const local = (path: string) => ({
     localPath: path,
@@ -111,7 +111,7 @@ test('a fetch for some haplotypes answers those lanes in the order asked, named
 })
 
 test('a fetch for some haplotypes reads them against a reference walk named without a haplotype', async () => {
-  const found = await feats(makeAdapter({}, 'walks3_twopart'), {
+  const found = await feats(makeAdapter({}, 'walks4_twopart'), {
     haplotypes: ['HG002#1'],
   })
   expect(found.map(summary)).toEqual([
@@ -172,7 +172,7 @@ test('a batch of lane pairs answers each pair what it answers alone', async () =
   expect(batch).toHaveLength(2)
 })
 
-// walks3_lanepairs, a 5.5 kb reference of 2 kb flanks around three 500 bp
+// walks4_lanepairs, a 5.5 kb reference of 2 kb flanks around three 500 bp
 // nodes, in 1 kb chunks:
 //   W GRCh38  0 chr1 >1>2>3>4>5
 //   W HG002   1 chr1 >1>2>3>4>5
@@ -180,7 +180,7 @@ test('a batch of lane pairs answers each pair what it answers alone', async () =
 //   W HG00097 1 chr1 >1>2>6>2>6>2>3>4>5   2 three times, 6 a 30 bp spacer
 test('a lane pair matches through a copy-number array, and draws an inversion between the lanes as a reverse-strand record', async () => {
   const found = await firstValueFrom(
-    makeAdapter({}, 'walks3_lanepairs')
+    makeAdapter({}, 'walks4_lanepairs')
       .getFeatures(
         { ...window, end: 5500 },
         {
@@ -554,7 +554,7 @@ test('a walk turned against the reference for 10 kb or more gains a reverse-stra
 //   W HG00097 1 chr1 >1>2>3>4>5
 test('the anchor window answers a haplotype turned against the reference with a reverse-strand record of the turned stretch', async () => {
   const records = await firstValueFrom(
-    makeAdapter({}, 'walks3_inversion')
+    makeAdapter({}, 'walks4_inversion')
       .getFeatures({ ...window, end: 55_000 }, {})
       .pipe(toArray()),
   )

package/src/WalkTabixSyntenyAdapter/configSchema.ts

@@ -25,14 +25,14 @@ import type { Instance } from '@jbrowse/mobx-state-tree'
  *
  * `walksUri` takes the prefix of one reference's walk file, `<prefix>.<sample>`,
  * and resolves `<walksUri>.walks.bed.gz` and its `.tbi`. The adapter reads walk
- * format 3, which gfa-to-tabix writes from 1.1, through @jbrowse/graph-walks.
+ * format 4, which gfa-to-tabix writes from 1.2, through @jbrowse/graph-walks.
  * Only a window on the anchor is answered.
  *
  * #example
  * ```js
  * {
  *   type: 'WalkTabixSyntenyAdapter',
- *   walksUri: 'https://example.org/hprc-v2.1-mc-grch38.GRCh38',
+ *   walksUri: 'https://jbrowse.org/demos/hprc/hprc-v2.1-mc-grch38-f4.GRCh38',
  *   assemblyNames: ['hg38'],
  *   assemblyNameToPanSN: { hg38: 'GRCh38' },
  * }
@@ -56,7 +56,7 @@ const WalkTabixSyntenyAdapter = ConfigurationSchema(
     },
     /**
      * #slot
-     * a `gfa-to-tabix --walks` file in walk format 3
+     * a `gfa-to-tabix --walks` file in walk format 4
      */
     walksLocation: fileLocationSlot('/path/to/graph.walks.bed.gz'),
     /**

package/src/WalkTabixSyntenyAdapter/gbzParity.test.ts

@@ -12,10 +12,10 @@ import type { Feature } from '@jbrowse/core/util'
 import type { SyntenyMate } from '@jbrowse/synteny-core'
 
 // chr22 of HPRC v2.1 as a gbz-base database and as gfa-to-tabix's GRCh38
-// walk file in walk format 3, built 2026-10-08 and 2026-10-16. Skipped where
+// walk file in walk format 4, built 2026-10-08 and 2026-10-20. Skipped where
 // the files are absent.
 const dir = '/home/cdiesh/work/scratch/walks-20261008'
-const walkPrefix = `${dir}/f3/chr22.GRCh38`
+const walkPrefix = `${dir}/f4/chr22.GRCh38`
 const present =
   existsSync(`${walkPrefix}.walks.bed.gz`) && existsSync(`${dir}/chr22.gbz.db`)
 

package/src/panSNAliases/panSNAliases.test.ts

@@ -123,11 +123,11 @@ describe("a lanes track anchored on an alias of the window's assembly", () => {
           {
             type: 'WalkTabixSyntenyAdapter',
             walksLocation: local(
-              '../RgfaTabixAdapter/test_data/walks3_header.GRCh38.walks.bed.gz',
+              '../RgfaTabixAdapter/test_data/walks4_header.GRCh38.walks.bed.gz',
             ),
             walksIndex: {
               location: local(
-                '../RgfaTabixAdapter/test_data/walks3_header.GRCh38.walks.bed.gz.tbi',
+                '../RgfaTabixAdapter/test_data/walks4_header.GRCh38.walks.bed.gz.tbi',
               ),
             },
             assemblyNames: ['GRCh38'],

package/src/version.ts

@@ -1 +1 @@
-export const version = '7.3.0'
+export const version = '7.3.1'

package/dist/chunks/chunk-B2EP6FOQ.js

@@ -1,3 +0,0 @@
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Wt(t,e,A){let n=o=>o.rank!==0||o.refName!==A.refName?0:o.end<=A.start?-1:o.start>=A.end?1:0,i=new Map(t),r=new Map;for(let o of e)(t.has(o.source)||t.has(o.target)||n(o.sourceSegment)*n(o.targetSegment)===-1)&&$A(i,r,o);for(let o of e)i.has(o.source)&&i.has(o.target)&&r.set(Ke(o),o);return{segments:i,links:r}}function Vt(t,e,A){let n=i=>i.refName!==A.refName||i.end<=A.start||i.start>=A.end;return[...jt(t.filter(i=>i.rank>0),i=>e.has(i.id),A.end-A.start),...jt(t.filter(i=>i.rank===0&&n(i)),()=>!0,0)]}function jt(t,e,A){let n=[...t].sort((r,o)=>VA(r.refName,o.refName)||r.start-o.start),i=[];for(let r of n){let o=i.at(-1);o?.refName===r.refName&&r.start-o.end<=A?(o.needed||(o.needed=r.start>o.end||e(r)),o.end=Math.max(o.end,r.end)):i.push({refName:r.refName,start:r.start,end:r.end,needed:e(r)})}return i.filter(r=>r.needed).map(({refName:r,start:o,end:a})=>({refName:r,start:o,end:a}))}function $t(t,e,A){let 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A;a--,s+=n[r++]<<g,g+=8}A.lens[x[A.have++]]=s&7,s>>>=3,g-=3}for(;A.have<19;)A.lens[x[A.have++]]=0;if(A.lencode=A.lendyn,A.lenbits=7,D={bits:A.lenbits},w=QA(rr,A.lens,0,19,A.lencode,0,A.work,D),A.lenbits=D.bits,w){t.msg="invalid code lengths set",A.mode=R;break}A.have=0,A.mode=vn;case vn:for(;A.have<A.nlen+A.ndist;){for(;d=A.lencode[s&(1<<A.lenbits)-1],k=d>>>24,p=d>>>16&255,m=d&65535,!(k<=g);){if(a===0)break A;a--,s+=n[r++]<<g,g+=8}if(m<16)s>>>=k,g-=k,A.lens[A.have++]=m;else{if(m===16){for(y=k+2;g<y;){if(a===0)break A;a--,s+=n[r++]<<g,g+=8}if(s>>>=k,g-=k,A.have===0){t.msg="invalid bit length repeat",A.mode=R;break}c=A.lens[A.have-1],Q=3+(s&3),s>>>=2,g-=2}else if(m===17){for(y=k+3;g<y;){if(a===0)break A;a--,s+=n[r++]<<g,g+=8}s>>>=k,g-=k,c=0,Q=3+(s&7),s>>>=3,g-=3}else{for(y=k+7;g<y;){if(a===0)break A;a--,s+=n[r++]<<g,g+=8}s>>>=k,g-=k,c=0,Q=11+(s&127),s>>>=7,g-=7}if(A.have+Q>A.nlen+A.ndist){t.msg="invalid bit length 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Yr(t,e,A,n){if(e>2**(A+n*3))return;let i=(8**(n+1)-1)/7,r=(8**n-1)/7+Math.floor((e-1)/2**A)+1;for(r>=i&&(r=0);;){for(;r%8===1;)r=(r-1)/8;if(r===0)return;let o=t[r];if(o?.length){let a=o[0].minv;for(let C=1;C<o.length;C++){let s=o[C].minv;s.compareTo(a)<0&&(a=s)}return a}r++}}function yi(t,e){return t.format==="GAF"?0:t.refNameToId[e]}var fA=class{filehandle;parseCache=new iA({});constructor({filehandle:e}){this.filehandle=e}async readIndexBytes(e){let A=await this.filehandle.readFile({signal:e.signal,onProgress:e.onProgress}),n=await UA(A);return{bytes:n,dataView:new DataView(n.buffer,n.byteOffset,n.byteLength)}}async lineCount(e,A={}){let n=await this.parse(A),i=yi(n,e);return i===void 0?-1:n.indices(i)?.stats?.lineCount??-1}async getMetadata(e={}){let{indices:A,...n}=await this.parse(e);return n}async blocksForRange(e,A,n,i={}){let r=await this.parse(i),o=yi(r,e);if(o===void 0)return[];let a=r.indices(o);if(!a)return[];r.format==="GAF"&&(A=Math.max(A-1,0));let C=[];for(let[f,h]of this.reg2bins(A,n,r))for(let Q=f;Q<=h;Q++){let E=a.binIndex[Q];if(E)for(let u of E)C.push(u)}let s=Ee(C,this.lowestOffset(a,A,r)),g=Yr(a.binIndex,n,r.minShift,r.depth);if(g){let f=s.length;for(;f>0&&s[f-1].minv.compareTo(g)>=0;)f--;s.length=f}return s}parse(e={}){return this.parseCache.get("index",e.signal,A=>this._parse({...e,signal:A}))}async hasRefSeq(e,A={}){return!!(await this.parse(A)).indices(e)?.binIndex}};var Hr=21582659,Kr=38359875;function xi(t,e){return t*2**e}function pt(t,e){return Math.floor(t/2**e)}var lA=class extends fA{async _parse(e={}){let{bytes:A,dataView:n}=await this.readIndexBytes(e),i=n.getUint32(0,!0),r;if(i===Hr)r=1;else if(i===Kr)r=2;else throw new Error(`Not a CSI file (magic=${i})`);let o=n.getInt32(4,!0),a=n.getInt32(8,!0),C=(8**(a+1)-1)/7,s=2**(o+a*3),g=n.getInt32(12,!0),f=g>=28&&(n.getInt32(16,!0)&15)===3;if(g<30&&!f)throw new Error("CSI index has no tabix header, so it names no references; it may be a BAM or BCF index");let h=he(A,16),Q=n.getInt32(16+g,!0),E=16+g+4,u,d=[];for(let p=0;p<Q;p++){d.push(E);let m=n.getInt32(E,!0);E+=4;for(let I=0;I<m;I++){let l=n.getUint32(E,!0);if(E+=4,l>C)E+=44;else{u=le(A,E,1,u),E+=8;let B=n.getInt32(E,!0);E+=4+16*B}}}function k(p){let m=d[p];if(m===void 0)return;let I=m,l=n.getInt32(I,!0);I+=4;let B={},c={},w;for(let N=0;N<l;N++){let D=n.getUint32(I,!0);if(I+=4,D>C)w=de(A,I+28),I+=44;else{c[D]=rA(A,I),I+=8;let y=n.getInt32(I,!0);I+=4;let x=Array.from({length:y});for(let S=0;S<y;S++)x[S]=new O(rA(A,I),rA(A,I+8),D),I+=16;B[D]=x}}return fe(Object.values(B).flat()),{binIndex:B,loffsets:c,stats:w}}return{...h,csi:!0,refCount:Q,maxBlockSize:65536,firstDataLine:u,csiVersion:r,indices:ue(k),minShift:o,depth:a,maxBinNumber:C,maxRefLength:s}}lowestOffset(e,A,{minShift:n,depth:i}){let{loffsets:r}=e,o;if(r){let a=(xi(1,3*i)-1)/7+pt(Math.max(A,0),n);for(;o===void 0&&a>0;)if(o=r[a],o===void 0){let C=Math.floor((a-1)/8),s=C*8+1;a=a>s?a-1:C}o??=r[0]}return 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s=t.indexOf(Fi,a);if((s===-1||s>i)&&(s=i),$r(t,a,s)){let g=pe(t,t[o]===45?o+1:o,C);g>r&&(r=g)}o=C+1,a=s+1}return r}var Ji=new TextDecoder;function Si(t,e){let A=-1,n=e.charCodeAt(0);for(let i=0,r=t.length;i<r;i++){let o=t[i];if(i===A+1&&o!==n)break;o===ke&&(A=i)}return t.subarray(0,A+1)}function eo(t,e){let A=0;for(let n=0;n<e;n++){let i=t.indexOf(ke,A);if(i===-1){A=t.length;break}A=i+1}return Ji.decode(t.subarray(0,A)).split(/\r?\n/).slice(0,e)}function pe(t,e,A){let n=0;for(let i=e;i<A;i++){let r=t[i];if(r>=48&&r<=57)n=n*10+(r-48);else break}return n}function to(t,e,A,n,i,{start:r,end:o,pathCol:a,metaCharCode:C,decoder:s,callback:g}){let f=0,h=0;for(;f<t.length;){let Q=t.indexOf(ke,f);if(Q===-1)break;let E=f;f=Q+1;let u=E+e+i;for(;h<n.length&&u>=n[h];)h++;if(t[E]===C)continue;let d=E;for(let B=1;B<a;B++){let c=t.indexOf(Dt,d);if(c===-1||c>=Q){d=Q;break}d=c+1}let k=t[d];if(k!==Or&&k!==Zr)continue;let p=t.indexOf(Dt,d);(p===-1||p>Q)&&(p=Q);let m=1/0,I=-1,l=d;for(;l<p;){let B=0,c=l+1;for(;c<p;c++){let w=t[c]-48;if(w<0||w>9)break;B=B*10+w}B<m&&(m=B),B>I&&(I=B),l=c}if(m>=o)return!0;if(I>=r){let B=t[Q-1]===Ri?Q-1:Q;g(s.decode(t.subarray(E,B)),vi(A,n,h,E+e,i),m,I+1)}}return!1}var DA=class{filehandle;index;chunkCache;headerCache=new iA({});bgzfWorkerPool;constructor({path:e,filehandle:A,url:n,tbiPath:i,tbiUrl:r,tbiFilehandle:o,csiPath:a,csiUrl:C,csiFilehandle:s,chunkCacheSize:g=Pr,chunkCacheIdleTimeoutMs:f=zr,chunkCacheBudget:h,bgzfWorkerPool:Q}){this.bgzfWorkerPool=Q,this.filehandle=jr(A,e,n),this.index=Wr({tbiFilehandle:o,csiFilehandle:s,tbiPath:i,csiPath:a,tbiUrl:r,csiUrl:C,path:e,url:n}),this.chunkCache=new iA({maxSize:g,sizeOf:E=>{let u=0;for(let d of E.segments)u+=d.byteLength;return u},cacheKey:E=>E.toString(),idleTimeoutMs:f,budget:h,fill:(E,u)=>this.readChunk(E,{signal:u})})}clearChunkCache(){this.chunkCache.clear()}async bytesForRegions(e,A={}){let n=[];for(let{refName:r,start:o,end:a}of e){let C=await this.index.blocksForRange(r,o,a,A);for(let s of C)n.push(s)}let i=0;for(let r of Ee(n))i+=r.fetchedSize();return i}async getLines(e,A,n,i){let r,o={},a,C;typeof i=="function"?a=i:(o=i,a=i.lineCallback,r=i.signal,C=i.onProgress);let s=await this.index.getMetadata(o),g=A??0,f=n??s.maxRefLength;if(g>f)throw new TypeError("invalid start and end coordinates. start must be less than or equal to end");if(g===f)return;let h=await this.index.blocksForRange(e,g,f,o),Q=s.format==="VCF",E=s.columnNumbers.ref||0,u=s.columnNumbers.start||0,d=Q?8:s.columnNumbers.end||0,k=Math.max(E,u,d),p=s.metaChar?.charCodeAt(0),m=s.coordinateType==="1-based-closed"?-1:0,I=new TextEncoder,l=new TextDecoder,B=I.encode(e),c=new Int32Array(k+1),w=s.format==="GAF"?{start:g,end:f,pathCol:u,metaCharCode:p,decoder:l,callback:a}:void 0,N=0;for(let F of h)N+=F.fetchedSize();let D=0;C?.(0,N);let y=1,x=[],S=F=>{for(;x.length<Math.min(F,h.length);){let L=h[x.length],J=this.chunkCache.get(L,r);J.catch(()=>{}),x.push(J)}};S(1);for(let F=0,L=h.length;F<L;F++){let J=h[F],{segments:M,cpositions:oA,dpositions:X}=await x[F];D+=J.fetchedSize(),C?.(D,N);let sA=J.minv.dataPosition;if(w){if(wt(M,(v,hA)=>to(v,hA,oA,X,sA,w)))return}else if(wt(M,(v,hA)=>{let H=0,HA=0;for(;H<v.length;){let K=v.indexOf(ke,H);if(K===-1)break;let Li=H+hA+sA;for(;HA<X.length&&Li>=X[HA];)HA++;if(p!==void 0&&v[H]===p){H=K+1;continue}c[0]=H-1;for(let T=0;T<k;T++){let TA=c[T],me=TA<K?v.indexOf(Dt,TA+1):-1;c[T+1]=me===-1||me>=K?K:me}let Nt=c[E-1]+1,yt=c[E]-Nt;if(yt!==B.length){H=K+1;continue}let xt=!0;for(let T=0;T<yt;T++)if(v[Nt+T]!==B[T]){xt=!1;break}if(!xt){H=K+1;continue}let KA=pe(v,c[u-1]+1,c[u])+m;if(KA>=f)return!0;let NA;if(d===0||d===u?NA=KA+1:Q?NA=Vr(v,KA,c[3]+1,c[4],c[d-1]+1,c[d],c[5]):NA=pe(v,c[d-1]+1,c[d]),NA>g){let T=v[K-1]===Ri?K-1:K,TA=l.decode(v.subarray(H,T));a(TA,vi(oA,X,HA,H+hA,sA),KA,NA)}H=K+1}return!1}))return;y=Math.min(y*2,Xr),S(F+1+y)}}async getMetadata(e={}){return this.index.getMetadata(e)}async readHeaderBytes(e){let{firstDataLine:A,maxBlockSize:n}=await this.getMetadata(e),i=(A?.blockPosition??0)+n,r=await this.filehandle.read(i,0,e);return UA(r)}async parseHeader(e){let{metaChar:A,skipLines:n=0}=await this.getMetadata(e),i=await this.readHeaderBytes(e);return{header:Ji.decode(A?Si(i,A):i),skippedLines:n>0?eo(i,n):[]}}getParsedHeader(e={}){return this.headerCache.get("header",e.signal,A=>this.parseHeader({...e,signal:A}))}async getHeaderBuffer(e={}){let{metaChar:A}=await this.getMetadata(e),n=await this.readHeaderBytes(e);return A?Si(n,A):n}async getSkippedLines(e={}){let{skipLines:A=0}=await this.getMetadata(e);return A<=0?[]:(await this.getParsedHeader(e)).skippedLines}async getHeader(e={}){return(await this.getParsedHeader(e)).header}async getHeaderLines(e={}){let{header:A,skippedLines:n}=await this.getParsedHeader(e);return(A?A.split(/\r?\n/):n).filter(Boolean)}async getReferenceSequenceNames(e={}){return(await this.getMetadata(e)).refIdToName}async lineCount(e,A={}){return this.index.lineCount(e,A)}async readChunk(e,A={}){let n=await this.filehandle.read(e.fetchedSize(),e.minv.blockPosition,A);BA(A.signal);let i=await this.bgzfWorkerPool;return Et(n,e,i)}};var no=t=>({type:"fileLocation",defaultValue:{uri:t,locationType:"UriLocation"}}),da=(t,e="")=>Ft(t,{indexType:{model:St.enumeration("IndexType",["TBI","CSI"]),type:"stringEnum",defaultValue:"TBI"},location:no(e)});function io(t,e,A){return{indexType:A?"CSI":"TBI",location:{uri:`${t}.${A?"csi":"tbi"}`,baseUri:e}}}function ua(t){let{walksUri:e,baseUri:A,csi:n}=t;if(typeof e!="string")return t;let i=`${e}.walks.bed.gz`;return{...t,walksLocation:{uri:i,baseUri:A},walksIndex:io(i,A,n)}}function wa(t,e,A){let n=t.pluginManager;return new DA({filehandle:Rt(t.getConf(e),n),...vt(t.getConf([...A,"location"]),t.getConf([...A,"indexType"]),n)})}function ro(t){return`${t.assemblyName} ${t.refName} is not in this graph's index; a graph with PanSN names (GRCh38#0#chr1) needs ${t.assemblyName} mapped to its prefix in assemblyNameToPanSN`}var Gi=class{constructor(e,A){this.file=e;this.adapter=A;this.lookup=Gt({setup:async e=>SA(await this.file.getReferenceSequenceNames(e))})}async assemblyRefNames(e={}){let A=await this.file.getReferenceSequenceNames(e),n=qA(this.adapter,e.assemblyName),i=A.filter(r=>De(r,n)).map(r=>bt(r));return i.length>0?[...new Set(i)]:A}async resolve(e,A){let n=await this.lookup(A);return RA(n,qA(this.adapter,e.assemblyName),e.refName)}async resolveMapped(e,A){let n=await this.resolve(e,A);if(n===void 0&&e.assemblyName){let i=await this.file.getReferenceSequenceNames(A),r=qA(this.adapter,e.assemblyName);if(i.every(o=>o.includes("#"))&&!i.some(o=>De(o,r)))throw new Error(ro(e))}return n}async regionBytes(e,A={},n=async i=>i){let i=[];for(let r of e){let o=await this.resolve(r,A);o!==void 0&&i.push({refName:o,start:await n(r.start),end:r.end})}return nn(this.file,i,A)}};export{UA as a,so as b,Gt as c,Ui as d,Je as e,zi as f,qe as g,Ye as h,Hi as i,ji as j,Lo as k,no as l,da as m,io as n,ua as o,wa as 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