jbrowse-plugin-graphgenomeviewer 7.2.1 → 7.3.1

package/dist/chunks/{GbzBaseSyntenyAdapter-FXMGIM7Z.js → GbzBaseSyntenyAdapter-NYI2YVNG.js}

@@ -1,2 +1,2 @@
-import{a as ne,b as ae,c as ue,d as re,e as oe,f as O,g as ie,h as se}from"./chunk-2O3YVA2I.js";import{a as te}from"./chunk-JCAZTNYG.js";import{a as ee}from"./chunk-KOB7YIMR.js";import{a as Q,b as D,c as Z,d as u,e as k,f as M,g as j,h as $,i as W,k as U}from"./chunk-WUSKVEA6.js";import"./chunk-RW775LQN.js";import{b as z,c as E}from"./chunk-VQ77X5QU.js";import"./chunk-M2D7NUOY.js";import"./chunk-YBLNN5FU.js";import"./chunk-6KUHGRHU.js";import"./chunk-6MUBJVBG.js";import{a as K,c as L,p as V}from"./chunk-B2EP6FOQ.js";import"./chunk-YBLNN5FU.js";import"./chunk-MVVXRZXV.js";import{g as F,h as N,i as C}from"./chunk-7HWHWPRW.js";import"./chunk-T4R3ZVEM.js";import{d as G,g as X,h as Y,i as J}from"./chunk-IKJZPPOA.js";import"./chunk-7WIBGKBU.js";import{a as P}from"./chunk-OGQ6OQDN.js";import"./chunk-NDRLCGPC.js";import{e as _,o as B}from"./chunk-TENPGIPX.js";function A(n){let i=/\.gbz\.db$/i;return i.test(n)?n.replace(i,".haplotype-index.db"):void 0}function ge(n){return Y(n)&&A(X(n))?J(n,i=>A(i)):void 0}function ye(n){return n instanceof Error&&(/\bHTTP 40[34]\b/.test(n.message)||n.code==="ENOENT")}async function ce(n,i){let e=ge(n);if(!e)return{};try{return await P(e,i).stat(),{location:e}}catch(t){return ye(t)?{}:{unreadable:String(t)}}}var be=5e3,we=50*2**20,H=class extends Error{constructor(e){super(`this GAF is ${(e/2**20).toFixed(0)} MB without an index; bgzip it and index it with tabix -p gaf`);this.name="UnindexedGafTooLargeError"}};function xe(n,i){if(n.length<=i)return n;let e=n.length/i;return Array.from({length:i},(t,a)=>n[Math.floor(a*e)])}var pe=(n,i)=>n.path.some(e=>i.has(e.name)),v=class{constructor(i,e){this.file=i;this.tabix=e;this.whole=L({setup:async({signal:i})=>{let{size:e}=await this.file.stat();if(e>we)throw new H(e);let t=await this.file.readFile({signal:i}),a=new TextDecoder().decode(t[0]===31&&t[1]===139?await K(t):t);return E(a)}})}async readIndexed(i,e,t){let a=1/0,r=-1/0;for(let s of e){let c=Number(s);Number.isInteger(c)&&(a=Math.min(a,c),r=Math.max(r,c))}let o=[];return a<=r&&await i.getLines("{node}",a,r+1,{signal:t,lineCallback:s=>{let c=z(s);c&&pe(c,e)&&o.push(c)}}),o}async readsOver(i,{signal:e}={}){let t=this.tabix?await this.readIndexed(this.tabix,i,e):(await this.whole({signal:e})).filter(a=>pe(a,i));return{records:xe(t,be),total:t.length}}};var I=class extends Error{constructor(e){super(e===void 0?"no haplotype index is set, so the walks cannot be named; build one with gbz-haplotype-index (cargo install gbz-haplotype-index) and set it as haplotypeIndexLocation":`the haplotype index beside the graph database could not be checked (${e}), so the walks cannot be named; if it is there, reload to try again, or set haplotypeIndexLocation`);this.name="NoHaplotypeIndexError"}},q=class extends Error{constructor(e,t){super(`the graph is cut on its reference, ${t}; a window on ${e} has no reference coordinates to cut at. Open the graph from a ${t} view, and find this haplotype's lane there`);this.name="HaplotypeWindowError"}};function Se(n,i){return`${u(n)}#${n.contig}@${i.start.node}.${i.start.offset}`}function Ne({alignment:n,assemblyName:i,refName:e,lane:t}){let{refStart:a,refEnd:r,strand:o,cigar:s}=n;if(!(r<=a)){let{name:c,hapStart:p,hapEnd:l}=n,f=Se(c,n),g={uniqueId:f,assemblyName:i,refName:e,start:a,end:r,type:"match",strand:o==="-"?-1:1,CIGAR:s,syntenyId:f,mate:{refName:c.contig,start:p,end:l,assemblyName:t}};return new ne(g)}}function Pe({pair:n,lane:i,mateLane:e}){return se({target:{name:`${u(n.target)}#${n.target.contig}`,assemblyName:i,refName:n.target.contig,start:n.targetStart,end:n.targetEnd},query:{name:`${u(n.query)}#${n.query.contig}`,assemblyName:e,refName:n.query.contig,start:n.queryStart,end:n.queryEnd},strand:n.strand,cigar:n.cigar,matches:n.matches,columns:n.columns})}var Le=12e4;function Re(n,i){let e=new Map;for(let a of n)for(let{name:r,start:o,end:s}of a.walkSpans()){let c=u(r);if(i.has(c)){let p=`${c}#${r.contig}`,l=e.get(p);l?l.push([o,s]):e.set(p,[[o,s]])}}let t=0;for(let a of e.values()){a.sort((r,o)=>r[0]-o[0]);for(let r=1;r<a.length;r++){let o=a[r][0]-a[r-1][1];o>0&&o<=Le&&(t=Math.max(t,o))}}return t}function fe(n,i){return n instanceof Z&&(n.message=`Zoom in to about ${_(n.fitsBp)} to see ${i}`),n}var le=(n,i,e)=>ie(fe(W(n,i,e)??n,"lanes"),e),me=n=>({...n,start:Math.floor(n.start),end:Math.ceil(n.end)}),T=class extends ae{constructor(){super(...arguments);this.graph=L({label:"Opening pangenome database",setup:async()=>{let e=this.getConf("gbzDbLocation"),t=this.getConf("haplotypeIndexLocation"),a=G(t)?{location:t}:await ce(e,this.pluginManager),r=a.location,o=await D.open({source:P(e,this.pluginManager),haplotypeIndex:r?P(r,this.pluginManager):void 0}),s=this.getConf("assemblyNames")[0];if(s===void 0)throw new Error("GbzBaseSyntenyAdapter needs assemblyNames: its first entry is the assembly the reference sample is loaded as");let c=await M(o),p=j({configured:this.getConf("referenceSample"),anchorPrefix:N(this,s),referenceSamples:c});return{db:o,anchor:s,referenceSample:p,referenceSamples:c,unreadableIndex:a.unreadable}}});this.gaf=L({label:"Opening reads",setup:async()=>{let e=this.getConf("readsLocation"),t=this.getConf(["readsIndex","location"]);return G(e)?new v(P(e,this.pluginManager),G(t)?V(this,["readsLocation"],["readsIndex"]):void 0):void 0}})}async referenceQuery(e,t){let{db:a,referenceSample:r}=await this.graph(t);return $(a,r,e)}async getHaplotypes(e={}){let{db:t,referenceSamples:a}=await this.graph(e),r=new Map;for(let o of await t.paths()){let s=u(o.name),c=r.get(s);c?c.contigs.includes(o.name.contig)||c.contigs.push(o.name.contig):r.set(s,{prefix:s,sample:o.name.sample,haplotype:o.name.haplotype,contigs:[o.name.contig],isReference:a.includes(o.name.sample)})}return[...r.values()]}async getHeader(e={}){let{anchor:t,referenceSample:a}=await this.graph(e),r=C(this),o=[];for(let s of await this.getHaplotypes(e))s.sample!==a&&o.push({name:O(r,s.prefix),label:s.prefix,group:s.sample});return{hasCoarseTier:!1,anchorAssemblyName:t,lanes:o}}async getRefNames(e={}){let{db:t,anchor:a,referenceSample:r}=await this.graph(e),{assemblyName:o}=e,s=o===a?void 0:N(this,o),c=(await t.paths()).filter(p=>o===a?p.isIndexed&&p.name.sample===r:F(u(p.name),s)).map(p=>p.name.contig);return[...new Set(c)]}keepPredicate(e,t){let a=e===void 0||e.length===0?void 0:e.map(r=>N(this,r));return a===void 0&&t===void 0?void 0:r=>k(r,a)&&(t===void 0||F(u(r),t))}async getSubgraph(e,t={}){let{signal:a}=t,{db:r,anchor:o,referenceSample:s,unreadableIndex:c}=await this.graph({signal:a}),{assemblyName:p,refName:l,start:f,end:g}=me(e);if(p!==o)throw new q(p,o);let y=await this.referenceQuery(l,{signal:a});if(!y)throw new Error(`${s} has no indexed path ${l} in this graph`);let b=this.keepPredicate(t.haplotypes);if(b!==void 0&&!r.hasHaplotypeIndex)throw new I(c);let d=await U(r,y,f,g,{context:this.getConf("context"),snarls:t.snarls??this.getConf("subgraphSnarls"),limit:this.getConf("nodeLimit"),signal:t.signal,keep:b}).catch(w=>{throw fe(w,"the graph")});return typeof d=="string"?d:te(d,{start:f,end:g},t.walkRows)}async getReads(e,t={}){let a=await this.gaf(t);return a?a.readsOver(new Set(e),t):{records:[],total:0}}async laneHaplotypes(e,t){let a=N(this,e);return(await this.getHaplotypes(t)).filter(r=>F(r.prefix,a))}async anchorFeatures(e,t){let{db:a}=await this.graph(t),{assemblyName:r,refName:o,start:s,end:c}=e,p=N(this,t.targetAssemblyName),l=C(this),f=this.keepPredicate(t.haplotypes,p),g=await this.referenceQuery(o,t),y=this.getConf("nodeLimit");return(g?await B(`Reading graph ${o}:${s.toLocaleString()}-${c.toLocaleString()}`,t.statusCallback,()=>a.getAlignments({path:g,start:s,end:c,context:this.getConf("context"),haplotypes:"all",limit:y,signal:t.signal,keep:f}).catch(d=>{throw le(d,y,c-s)})):[]).flatMap(d=>{let w=d.resolved?Ne({alignment:d,assemblyName:r,refName:o,lane:O(l,u(d.name))}):void 0;return w===void 0?[]:[w]})}async pairFeatures(e,t,a){let{db:r}=await this.graph(a),{refName:o,start:s,end:c}=e,l=(await Promise.all(t.map(async m=>({pair:m,featureSide:await this.laneHaplotypes(m.queryAssemblyName,a),mateSide:await this.laneHaplotypes(m.targetAssemblyName,a)})))).filter(({featureSide:m,mateSide:h})=>m.length>0&&h.length>0),f=new Set(l.flatMap(({featureSide:m,mateSide:h})=>[...m,...h].map(u))),g=await this.referenceQuery(o,a),y=this.getConf("nodeLimit"),b=this.getConf("context"),d=(m,h)=>r.getSubgraphs({path:m,start:s,end:c,context:h,snarls:this.getConf("subgraphSnarls"),haplotypes:"all",limit:y,signal:a.signal,keep:x=>f.has(u(x))}),w=async m=>{let h=await d(m,b).catch(S=>{throw le(S,y,c-s)}),x=Re(h,f),R=Math.ceil(x/2)+2e3;return x>0&&R>b?d(m,R).catch(S=>{if(S instanceof Q)return h;throw S}):h};return(g&&l.length>0?await B(oe(t),a.statusCallback,()=>w(g)):[]).flatMap(m=>l.flatMap(({pair:h,featureSide:x,mateSide:R})=>x.flatMap(S=>R.flatMap(de=>m.pairAlignments({target:S,query:de,bases:!1}).map(he=>Pe({pair:he,lane:h.queryAssemblyName,mateLane:h.targetAssemblyName}))))))}getFeatures(e,t={}){let a=me(e);return ee(async r=>{let{db:o,anchor:s,unreadableIndex:c}=await this.graph(t);if(!o.hasHaplotypeIndex)throw new I(c);if(a.assemblyName===s){let p=re(t),l=p.length>0?await this.pairFeatures(a,p,t):await this.anchorFeatures(a,t);for(let f of l)r.next(f)}r.complete()},t.signal)}};export{I as NoHaplotypeIndexError,ue as PairTargetError,T as default,Re as widestWalkGap};
-//# sourceMappingURL=GbzBaseSyntenyAdapter-FXMGIM7Z.js.map
+import{a as ne,b as ae,c as ue,d as re,e as oe,f as O,g as ie,h as se}from"./chunk-YXVEGNFQ.js";import{a as te}from"./chunk-JCAZTNYG.js";import{a as ee}from"./chunk-KOB7YIMR.js";import{a as Q,b as D,c as Z,d as u,e as k,f as M,g as j,h as $,i as W,k as U}from"./chunk-WUSKVEA6.js";import"./chunk-RW775LQN.js";import{b as z,c as E}from"./chunk-VQ77X5QU.js";import"./chunk-M2D7NUOY.js";import"./chunk-YBLNN5FU.js";import"./chunk-6KUHGRHU.js";import"./chunk-6MUBJVBG.js";import{a as K,c as L,p as V}from"./chunk-BKBH3WGW.js";import"./chunk-YBLNN5FU.js";import"./chunk-MVVXRZXV.js";import{g as F,h as N,i as C}from"./chunk-7HWHWPRW.js";import"./chunk-T4R3ZVEM.js";import{d as G,g as X,h as Y,i as J}from"./chunk-IKJZPPOA.js";import"./chunk-7WIBGKBU.js";import{a as P}from"./chunk-OGQ6OQDN.js";import"./chunk-NDRLCGPC.js";import{e as _,o as B}from"./chunk-TENPGIPX.js";function A(n){let i=/\.gbz\.db$/i;return i.test(n)?n.replace(i,".haplotype-index.db"):void 0}function ge(n){return Y(n)&&A(X(n))?J(n,i=>A(i)):void 0}function ye(n){return n instanceof Error&&(/\bHTTP 40[34]\b/.test(n.message)||n.code==="ENOENT")}async function ce(n,i){let e=ge(n);if(!e)return{};try{return await P(e,i).stat(),{location:e}}catch(t){return ye(t)?{}:{unreadable:String(t)}}}var be=5e3,we=50*2**20,H=class extends Error{constructor(e){super(`this GAF is ${(e/2**20).toFixed(0)} MB without an index; bgzip it and index it with tabix -p gaf`);this.name="UnindexedGafTooLargeError"}};function xe(n,i){if(n.length<=i)return n;let e=n.length/i;return Array.from({length:i},(t,a)=>n[Math.floor(a*e)])}var pe=(n,i)=>n.path.some(e=>i.has(e.name)),v=class{constructor(i,e){this.file=i;this.tabix=e;this.whole=L({setup:async({signal:i})=>{let{size:e}=await this.file.stat();if(e>we)throw new H(e);let t=await this.file.readFile({signal:i}),a=new TextDecoder().decode(t[0]===31&&t[1]===139?await K(t):t);return E(a)}})}async readIndexed(i,e,t){let a=1/0,r=-1/0;for(let s of e){let c=Number(s);Number.isInteger(c)&&(a=Math.min(a,c),r=Math.max(r,c))}let o=[];return a<=r&&await i.getLines("{node}",a,r+1,{signal:t,lineCallback:s=>{let c=z(s);c&&pe(c,e)&&o.push(c)}}),o}async readsOver(i,{signal:e}={}){let t=this.tabix?await this.readIndexed(this.tabix,i,e):(await this.whole({signal:e})).filter(a=>pe(a,i));return{records:xe(t,be),total:t.length}}};var I=class extends Error{constructor(e){super(e===void 0?"no haplotype index is set, so the walks cannot be named; build one with gbz-haplotype-index (cargo install gbz-haplotype-index) and set it as haplotypeIndexLocation":`the haplotype index beside the graph database could not be checked (${e}), so the walks cannot be named; if it is there, reload to try again, or set haplotypeIndexLocation`);this.name="NoHaplotypeIndexError"}},q=class extends Error{constructor(e,t){super(`the graph is cut on its reference, ${t}; a window on ${e} has no reference coordinates to cut at. Open the graph from a ${t} view, and find this haplotype's lane there`);this.name="HaplotypeWindowError"}};function Se(n,i){return`${u(n)}#${n.contig}@${i.start.node}.${i.start.offset}`}function Ne({alignment:n,assemblyName:i,refName:e,lane:t}){let{refStart:a,refEnd:r,strand:o,cigar:s}=n;if(!(r<=a)){let{name:c,hapStart:p,hapEnd:l}=n,f=Se(c,n),g={uniqueId:f,assemblyName:i,refName:e,start:a,end:r,type:"match",strand:o==="-"?-1:1,CIGAR:s,syntenyId:f,mate:{refName:c.contig,start:p,end:l,assemblyName:t}};return new ne(g)}}function Pe({pair:n,lane:i,mateLane:e}){return se({target:{name:`${u(n.target)}#${n.target.contig}`,assemblyName:i,refName:n.target.contig,start:n.targetStart,end:n.targetEnd},query:{name:`${u(n.query)}#${n.query.contig}`,assemblyName:e,refName:n.query.contig,start:n.queryStart,end:n.queryEnd},strand:n.strand,cigar:n.cigar,matches:n.matches,columns:n.columns})}var Le=12e4;function Re(n,i){let e=new Map;for(let a of n)for(let{name:r,start:o,end:s}of a.walkSpans()){let c=u(r);if(i.has(c)){let p=`${c}#${r.contig}`,l=e.get(p);l?l.push([o,s]):e.set(p,[[o,s]])}}let t=0;for(let a of e.values()){a.sort((r,o)=>r[0]-o[0]);for(let r=1;r<a.length;r++){let o=a[r][0]-a[r-1][1];o>0&&o<=Le&&(t=Math.max(t,o))}}return t}function fe(n,i){return n instanceof Z&&(n.message=`Zoom in to about ${_(n.fitsBp)} to see ${i}`),n}var le=(n,i,e)=>ie(fe(W(n,i,e)??n,"lanes"),e),me=n=>({...n,start:Math.floor(n.start),end:Math.ceil(n.end)}),T=class extends ae{constructor(){super(...arguments);this.graph=L({label:"Opening pangenome database",setup:async()=>{let e=this.getConf("gbzDbLocation"),t=this.getConf("haplotypeIndexLocation"),a=G(t)?{location:t}:await ce(e,this.pluginManager),r=a.location,o=await D.open({source:P(e,this.pluginManager),haplotypeIndex:r?P(r,this.pluginManager):void 0}),s=this.getConf("assemblyNames")[0];if(s===void 0)throw new Error("GbzBaseSyntenyAdapter needs assemblyNames: its first entry is the assembly the reference sample is loaded as");let c=await M(o),p=j({configured:this.getConf("referenceSample"),anchorPrefix:N(this,s),referenceSamples:c});return{db:o,anchor:s,referenceSample:p,referenceSamples:c,unreadableIndex:a.unreadable}}});this.gaf=L({label:"Opening reads",setup:async()=>{let e=this.getConf("readsLocation"),t=this.getConf(["readsIndex","location"]);return G(e)?new v(P(e,this.pluginManager),G(t)?V(this,["readsLocation"],["readsIndex"]):void 0):void 0}})}async referenceQuery(e,t){let{db:a,referenceSample:r}=await this.graph(t);return $(a,r,e)}async getHaplotypes(e={}){let{db:t,referenceSamples:a}=await this.graph(e),r=new Map;for(let o of await t.paths()){let s=u(o.name),c=r.get(s);c?c.contigs.includes(o.name.contig)||c.contigs.push(o.name.contig):r.set(s,{prefix:s,sample:o.name.sample,haplotype:o.name.haplotype,contigs:[o.name.contig],isReference:a.includes(o.name.sample)})}return[...r.values()]}async getHeader(e={}){let{anchor:t,referenceSample:a}=await this.graph(e),r=C(this),o=[];for(let s of await this.getHaplotypes(e))s.sample!==a&&o.push({name:O(r,s.prefix),label:s.prefix,group:s.sample});return{hasCoarseTier:!1,anchorAssemblyName:t,lanes:o}}async getRefNames(e={}){let{db:t,anchor:a,referenceSample:r}=await this.graph(e),{assemblyName:o}=e,s=o===a?void 0:N(this,o),c=(await t.paths()).filter(p=>o===a?p.isIndexed&&p.name.sample===r:F(u(p.name),s)).map(p=>p.name.contig);return[...new Set(c)]}keepPredicate(e,t){let a=e===void 0||e.length===0?void 0:e.map(r=>N(this,r));return a===void 0&&t===void 0?void 0:r=>k(r,a)&&(t===void 0||F(u(r),t))}async getSubgraph(e,t={}){let{signal:a}=t,{db:r,anchor:o,referenceSample:s,unreadableIndex:c}=await this.graph({signal:a}),{assemblyName:p,refName:l,start:f,end:g}=me(e);if(p!==o)throw new q(p,o);let y=await this.referenceQuery(l,{signal:a});if(!y)throw new Error(`${s} has no indexed path ${l} in this graph`);let b=this.keepPredicate(t.haplotypes);if(b!==void 0&&!r.hasHaplotypeIndex)throw new I(c);let d=await U(r,y,f,g,{context:this.getConf("context"),snarls:t.snarls??this.getConf("subgraphSnarls"),limit:this.getConf("nodeLimit"),signal:t.signal,keep:b}).catch(w=>{throw fe(w,"the graph")});return typeof d=="string"?d:te(d,{start:f,end:g},t.walkRows)}async getReads(e,t={}){let a=await this.gaf(t);return a?a.readsOver(new Set(e),t):{records:[],total:0}}async laneHaplotypes(e,t){let a=N(this,e);return(await this.getHaplotypes(t)).filter(r=>F(r.prefix,a))}async anchorFeatures(e,t){let{db:a}=await this.graph(t),{assemblyName:r,refName:o,start:s,end:c}=e,p=N(this,t.targetAssemblyName),l=C(this),f=this.keepPredicate(t.haplotypes,p),g=await this.referenceQuery(o,t),y=this.getConf("nodeLimit");return(g?await B(`Reading graph ${o}:${s.toLocaleString()}-${c.toLocaleString()}`,t.statusCallback,()=>a.getAlignments({path:g,start:s,end:c,context:this.getConf("context"),haplotypes:"all",limit:y,signal:t.signal,keep:f}).catch(d=>{throw le(d,y,c-s)})):[]).flatMap(d=>{let w=d.resolved?Ne({alignment:d,assemblyName:r,refName:o,lane:O(l,u(d.name))}):void 0;return w===void 0?[]:[w]})}async pairFeatures(e,t,a){let{db:r}=await this.graph(a),{refName:o,start:s,end:c}=e,l=(await Promise.all(t.map(async m=>({pair:m,featureSide:await this.laneHaplotypes(m.queryAssemblyName,a),mateSide:await this.laneHaplotypes(m.targetAssemblyName,a)})))).filter(({featureSide:m,mateSide:h})=>m.length>0&&h.length>0),f=new Set(l.flatMap(({featureSide:m,mateSide:h})=>[...m,...h].map(u))),g=await this.referenceQuery(o,a),y=this.getConf("nodeLimit"),b=this.getConf("context"),d=(m,h)=>r.getSubgraphs({path:m,start:s,end:c,context:h,snarls:this.getConf("subgraphSnarls"),haplotypes:"all",limit:y,signal:a.signal,keep:x=>f.has(u(x))}),w=async m=>{let h=await d(m,b).catch(S=>{throw le(S,y,c-s)}),x=Re(h,f),R=Math.ceil(x/2)+2e3;return x>0&&R>b?d(m,R).catch(S=>{if(S instanceof Q)return h;throw S}):h};return(g&&l.length>0?await B(oe(t),a.statusCallback,()=>w(g)):[]).flatMap(m=>l.flatMap(({pair:h,featureSide:x,mateSide:R})=>x.flatMap(S=>R.flatMap(de=>m.pairAlignments({target:S,query:de,bases:!1}).map(he=>Pe({pair:he,lane:h.queryAssemblyName,mateLane:h.targetAssemblyName}))))))}getFeatures(e,t={}){let a=me(e);return ee(async r=>{let{db:o,anchor:s,unreadableIndex:c}=await this.graph(t);if(!o.hasHaplotypeIndex)throw new I(c);if(a.assemblyName===s){let p=re(t),l=p.length>0?await this.pairFeatures(a,p,t):await this.anchorFeatures(a,t);for(let f of l)r.next(f)}r.complete()},t.signal)}};export{I as NoHaplotypeIndexError,ue as PairTargetError,T as default,Re as widestWalkGap};
+//# sourceMappingURL=GbzBaseSyntenyAdapter-NYI2YVNG.js.map

package/dist/chunks/{MinigraphBubbleAdapter-QCOMFPLL.js → MinigraphBubbleAdapter-ABZPIZYV.js}

@@ -1,2 +1,2 @@
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-//# sourceMappingURL=MinigraphBubbleAdapter-QCOMFPLL.js.map
+import{a as f,d as c,f as d}from"./chunk-FIRQAKMX.js";import{a as g}from"./chunk-KOB7YIMR.js";import{b,k as m,p,r as u}from"./chunk-BKBH3WGW.js";import"./chunk-YBLNN5FU.js";import"./chunk-MVVXRZXV.js";import"./chunk-7HWHWPRW.js";import"./chunk-OGQ6OQDN.js";import"./chunk-NDRLCGPC.js";import{a as i,o as l}from"./chunk-TENPGIPX.js";var a=class extends b{constructor(){super(...arguments);this.bubbles=p(this,["bubblesLocation"],["index"]);this.refNames=new u(this.bubbles,this)}static{this.capabilities=["getFeatures","getRefNames"]}async getRefNames(t={}){return this.refNames.assemblyRefNames(t)}async getRegionByteSize(t,s={}){return this.refNames.regionBytes(t,s)}async hasDataForRefName(){return!0}getFeatures(t,s={}){let{signal:n,statusCallback:h}=s;return g(async r=>{let o=await this.refNames.resolveMapped(t,s);o!==void 0&&await l("Downloading bubbles",h,()=>m(this.bubbles,o,t.start,t.end,{signal:n,lineCallback:(N,y)=>{let e=f(N);r.next(new i({uniqueId:`bubble-${y}`,refName:t.refName,start:e.start,end:e.end,name:c(e),description:d(e),type:"bubble",score:e.segmentCount,segmentCount:e.segmentCount,pathCount:e.pathCount,inversion:e.inversion,shortestAlleleLength:e.shortestAlleleLength,longestAlleleLength:e.longestAlleleLength,segments:e.segments,shortestAllele:e.shortestAllele,longestAllele:e.longestAllele}))}})),r.complete()},n)}};export{a as default};
+//# sourceMappingURL=MinigraphBubbleAdapter-ABZPIZYV.js.map

package/dist/chunks/{RgfaTabixAdapter-O3NMNRZ2.js → RgfaTabixAdapter-3NQC5QPT.js}

@@ -1,2 +1,2 @@
-import{a as b}from"./chunk-YKSUKPYY.js";import"./chunk-JCAZTNYG.js";import{a as N}from"./chunk-KOB7YIMR.js";import"./chunk-YBLNN5FU.js";import"./chunk-6KUHGRHU.js";import"./chunk-6MUBJVBG.js";import{b as g,h as c,i as u,j as h,k as w,p as m,q as k,r as x}from"./chunk-B2EP6FOQ.js";import"./chunk-YBLNN5FU.js";import"./chunk-MVVXRZXV.js";import"./chunk-7HWHWPRW.js";import{d}from"./chunk-IKJZPPOA.js";import"./chunk-OGQ6OQDN.js";import"./chunk-NDRLCGPC.js";import{a as p,o as f}from"./chunk-TENPGIPX.js";var l=class extends g{constructor(){super(...arguments);this.fine=this.openIndex([])}static{this.capabilities=["getFeatures","getRefNames"]}openIndex(e){let t=m(this,[...e,"segmentsLocation"],[...e,"segmentsIndex"]),s=m(this,[...e,"linksLocation"],[...e,"linksIndex"]),n=this.getConf("walksLocation"),i=e.length===0&&d(n)?new b(m(this,["walksLocation"],["walksIndex"]),this):void 0;return{segments:t,links:s,walks:i,refNames:new x(i?.file??t,this)}}async getHaplotypeNames(e={}){return this.fine.walks?.haplotypeNames(e)}index(e="fine"){return e==="fine"?this.fine:(this.coarse??=this.openIndex(["coarse"]),this.coarse)}async getRefNames(e={}){return this.fine.refNames.assemblyRefNames(e)}async getRegionByteSize(e,t={}){let{walks:s,refNames:n}=this.fine;return n.regionBytes(e,t,s&&(i=>s.reader.queryStart(i,t)))}async hasDataForRefName(){return!0}getFeatures(e,t={}){return N(async s=>{let n=await this.fine.refNames.resolveMapped(e,t);if(n!==void 0){let{walks:i}=this.fine,a=r=>{s.next(r)};await(i?this.walkFeatures(i,n,e,t,a):this.segmentFeatures(n,e,t,a))}s.complete()},t.signal)}async walkFeatures(e,t,s,n,i){let a=await f("Downloading walks",n.statusCallback,()=>e.referenceNodes(t,s,n));for(let r of a){let o=String(r.id);i(new p({uniqueId:o,refName:s.refName,start:r.start,end:r.end,name:o,type:"segment",rank:0,stableName:r.refName}))}}async segmentFeatures(e,t,s,n){await f("Downloading segments",s.statusCallback,()=>w(this.fine.segments,e,t.start,t.end,{signal:s.signal,lineCallback:i=>{let{segment:a,anchored:r}=c(i);if(r&&a.refName!==e)return;let o=u(a);n(new p({uniqueId:a.id,refName:t.refName,start:a.start,end:a.end,name:a.id,type:"segment",rank:a.rank,stableName:a.refName,...o&&{samples:o,sampleCount:o.length}}))}}))}async getSubgraph(e,t={}){let{hops:s,signal:n,tier:i}=t,a=this.index(i),r=await a.refNames.resolve(e,{signal:n});if(r===void 0)throw new Error(k(e));return a.walks?a.walks.subgraph(r,e,t):h(a,{refName:r,start:e.start,end:e.end},{hops:s,signal:n})}};export{l as default};
-//# sourceMappingURL=RgfaTabixAdapter-O3NMNRZ2.js.map
+import{a as b}from"./chunk-QTOA4RB7.js";import"./chunk-JCAZTNYG.js";import{a as N}from"./chunk-KOB7YIMR.js";import"./chunk-YBLNN5FU.js";import"./chunk-6KUHGRHU.js";import"./chunk-6MUBJVBG.js";import{b as g,h as c,i as u,j as h,k as w,p as m,q as k,r as x}from"./chunk-BKBH3WGW.js";import"./chunk-YBLNN5FU.js";import"./chunk-MVVXRZXV.js";import"./chunk-7HWHWPRW.js";import{d}from"./chunk-IKJZPPOA.js";import"./chunk-OGQ6OQDN.js";import"./chunk-NDRLCGPC.js";import{a as p,o as f}from"./chunk-TENPGIPX.js";var l=class extends g{constructor(){super(...arguments);this.fine=this.openIndex([])}static{this.capabilities=["getFeatures","getRefNames"]}openIndex(e){let t=m(this,[...e,"segmentsLocation"],[...e,"segmentsIndex"]),s=m(this,[...e,"linksLocation"],[...e,"linksIndex"]),n=this.getConf("walksLocation"),i=e.length===0&&d(n)?new b(m(this,["walksLocation"],["walksIndex"]),this):void 0;return{segments:t,links:s,walks:i,refNames:new x(i?.file??t,this)}}async getHaplotypeNames(e={}){return this.fine.walks?.haplotypeNames(e)}index(e="fine"){return e==="fine"?this.fine:(this.coarse??=this.openIndex(["coarse"]),this.coarse)}async getRefNames(e={}){return this.fine.refNames.assemblyRefNames(e)}async getRegionByteSize(e,t={}){let{walks:s,refNames:n}=this.fine;return n.regionBytes(e,t,s&&(i=>s.reader.queryStart(i,t)))}async hasDataForRefName(){return!0}getFeatures(e,t={}){return N(async s=>{let n=await this.fine.refNames.resolveMapped(e,t);if(n!==void 0){let{walks:i}=this.fine,a=r=>{s.next(r)};await(i?this.walkFeatures(i,n,e,t,a):this.segmentFeatures(n,e,t,a))}s.complete()},t.signal)}async walkFeatures(e,t,s,n,i){let a=await f("Downloading walks",n.statusCallback,()=>e.referenceNodes(t,s,n));for(let r of a){let o=String(r.id);i(new p({uniqueId:o,refName:s.refName,start:r.start,end:r.end,name:o,type:"segment",rank:0,stableName:r.refName}))}}async segmentFeatures(e,t,s,n){await f("Downloading segments",s.statusCallback,()=>w(this.fine.segments,e,t.start,t.end,{signal:s.signal,lineCallback:i=>{let{segment:a,anchored:r}=c(i);if(r&&a.refName!==e)return;let o=u(a);n(new p({uniqueId:a.id,refName:t.refName,start:a.start,end:a.end,name:a.id,type:"segment",rank:a.rank,stableName:a.refName,...o&&{samples:o,sampleCount:o.length}}))}}))}async getSubgraph(e,t={}){let{hops:s,signal:n,tier:i}=t,a=this.index(i),r=await a.refNames.resolve(e,{signal:n});if(r===void 0)throw new Error(k(e));return a.walks?a.walks.subgraph(r,e,t):h(a,{refName:r,start:e.start,end:e.end},{hops:s,signal:n})}};export{l as default};
+//# sourceMappingURL=RgfaTabixAdapter-3NQC5QPT.js.map

package/dist/chunks/WalkTabixSyntenyAdapter-ZJJ4SQHH.js

@@ -0,0 +1,2 @@
+import{a as K}from"./chunk-QTOA4RB7.js";import{b as q,d as U,e as X,f as O,g as z,h as G}from"./chunk-YXVEGNFQ.js";import"./chunk-JCAZTNYG.js";import{a as H}from"./chunk-KOB7YIMR.js";import{p as M,q as _,r as T}from"./chunk-M2D7NUOY.js";import"./chunk-YBLNN5FU.js";import"./chunk-6KUHGRHU.js";import"./chunk-6MUBJVBG.js";import{e as $,p as j,r as D}from"./chunk-BKBH3WGW.js";import"./chunk-YBLNN5FU.js";import"./chunk-MVVXRZXV.js";import{a as A,c as I,d as W,g as F,h as w,i as x}from"./chunk-7HWHWPRW.js";import"./chunk-T4R3ZVEM.js";import"./chunk-7WIBGKBU.js";import"./chunk-OGQ6OQDN.js";import"./chunk-NDRLCGPC.js";import{o as R}from"./chunk-TENPGIPX.js";var se=50;function re(r){let i=[];for(let e=0;e<r.length;e++){let[t,a]=r[e],[s,n]=r[e+1]??[];a===n&&a<=se&&(t==="I"&&s==="D"||t==="D"&&s==="I")?(i.push(["X",a]),e++):i.push([t,a])}return i}function v(r){return Array.from(r.ids,(i,e)=>2*i+r.rev[e])}function P(r,i){let e=r.get(i);return e===void 0?0:e.end-e.start}function V(r){let i=new Map,e=s=>{let n=P(r,s),o=i.get(n);return o===void 0&&(o="N".repeat(n),i.set(n,o)),o},t=new Map,a=s=>{let n=t.get(s);return n===void 0&&(n=v(s),t.set(s,n)),n};return(s,n)=>_({query:a(s),target:a(n),sequenceOf:e,bases:!1})}var B=100;function E(r,i,e){let t=r.at(-1);e>0&&(t?.[0]===i?t[1]+=e:r.push([i,e]))}function Z(r){let i=t=>P(r,t>>1),e=t=>{let a=new Float64Array(t.length+1);return t.forEach((s,n)=>{a[n+1]=a[n]+i(s)}),a};return(t,a)=>{let s=v(a),n=v(t),[o,l]=M(n,s,i),[u,f]=M(n.map(g=>g^1).reverse(),s,i),c=f>l,p=c?u:o,N=Math.max(l,f);if(N<B)return[];let d=e(s),h=e(n),y=g=>c?n.length-1-p[g][0]:p[g][0],m=[];p.forEach(([,g],k)=>{if(k>0){let[ee,te]=[y(k-1),y(k)].sort((ae,ne)=>ae-ne);E(m,"I",h[te]-h[ee+1]),E(m,"D",d[g]-d[p[k-1][1]+1])}E(m,"=",i(s[g]))});let[b,S]=[y(0),y(p.length-1)].sort((g,k)=>g-k);return[{queryStart:h[b],queryEnd:h[S+1],targetStart:d[p[0][1]],targetEnd:d[p.at(-1)[1]+1],strand:c?"-":"+",edits:m,sharedBases:N}]}}function oe(r){let i=new Map,e=new Set;r.ids.forEach((t,a)=>{i.has(t)?e.add(t):i.set(t,r.rev[a])});for(let t of e)i.delete(t);return i}function J(r){let i=new Map,e=t=>{let a=i.get(t);return a===void 0&&(a=oe(t),i.set(t,a)),a};return(t,a)=>{let s=e(a),n=0,o=0;for(let[l,u]of e(t)){let f=s.get(l);f===u?n+=P(r,l):f!==void 0&&(o+=P(r,l))}return{same:n,opposite:o}}}function Q(r){let i=Z(r),e=V(r),t=J(r);return(a,s)=>{let{same:n,opposite:o}=t(a,s);return n>=B&&o>=B?e(a,s):i(a,s)}}var ie=1e4;function Y(r){let i=Z(r),e=V(r),t=J(r);return(a,s)=>{let n=i(a,s),o=n[0]?.strand,{same:l,opposite:u}=t(a,s);return o===void 0||Math.min(l,u)<ie?n:[...n,...e(a,s).filter(f=>f.strand!==o)]}}function C({chain:r,target:i,query:e,assemblyName:t,refName:a,mateAssemblyName:s}){let n=re(r.edits);return G({target:{name:i.name,assemblyName:t,refName:a,start:i.hapStart+r.targetStart,end:i.hapStart+r.targetEnd},query:{name:e.name,assemblyName:s,refName:W(e.name),start:e.hapStart+r.queryStart,end:e.hapStart+r.queryEnd},strand:r.strand,cigar:T(n),matches:n.reduce((o,[l,u])=>o+(l==="="?u:0),0),columns:n.reduce((o,[,l])=>o+l,0)})}var me=r=>I(r.name)??r.name,L=class extends q{constructor(){super(...arguments);this.walks=new K(j(this,["walksLocation"],["walksIndex"]),this);this.refNames=new D(this.walks.file,this)}get anchor(){let e=this.getConf("assemblyNames")[0];if(e===void 0)throw new Error("WalkTabixSyntenyAdapter needs assemblyNames: its first entry is the assembly the reference sample is loaded as");return e}async getHaplotypeNames(e={}){return this.walks.haplotypeNames(e)}async getHeader(e={}){let{haplotypes:t}=await this.walks.reader.header(e),{anchor:a}=this,s=w(this,a),n=x(this);return{hasCoarseTier:!1,anchorAssemblyName:a,lanes:t.filter(o=>o!==s&&A(o)!==s).map(o=>({name:O(n,o),label:o,group:A(o)}))}}async getRefNames(e={}){let{assemblyName:t}=e;return t===void 0||t===this.anchor?this.refNames.assemblyRefNames({...e,assemblyName:this.anchor}):[]}async getSubgraph(e,t={}){let a=await this.refNames.resolve(e,{signal:t.signal});if(a===void 0)throw new Error(`${e.assemblyName} ${e.refName} is not in this graph's index; the graph is cut on ${this.anchor}, mapped to its PanSN prefix in assemblyNameToPanSN`);return this.walks.subgraph(a,e,t)}async laneWalks(e,t,a,s,n){return R(n,s.statusCallback,()=>this.walks.reader.cut(e,t,{...this.walks.budgets(),signal:s.signal,keep:$(a,e),links:!1}).catch(o=>{throw z(o,t.end-t.start)}))}async anchorFeatures(e,t,a){let s=a.haplotypes?.length?a.haplotypes.map(m=>w(this,m)):void 0,n=w(this,a.targetAssemblyName),o=n===void 0?s:s===void 0||s.some(m=>F(n,m)||F(m,n))?[n]:[];if(o?.length===0)return[];let{start:l,end:u}=t,{graph:f,fragments:c}=await this.laneWalks(e,t,o,a,`Reading walks ${t.refName}:${l.toLocaleString()}-${u.toLocaleString()}`),p=Y(f.nodes),N=x(this),d=c.filter(m=>m.name===e),h=m=>o===void 0?0:o.findIndex(b=>F(m.name,b));return c.filter(m=>m.name!==e&&h(m)>=0).sort((m,b)=>h(m)-h(b)).flatMap(m=>d.flatMap(b=>p(m,b).map(S=>C({chain:S,target:b,query:m,assemblyName:t.assemblyName,refName:t.refName,mateAssemblyName:O(N,me(m))}))))}async pairFeatures(e,t,a,s){let n=a.map(c=>({pair:c,featurePrefix:w(this,c.queryAssemblyName),matePrefix:w(this,c.targetAssemblyName)})),{graph:o,fragments:l}=await this.laneWalks(e,t,n.flatMap(c=>[c.featurePrefix,c.matePrefix]),s,X(a)),u=Q(o.nodes),f=c=>l.filter(p=>F(p.name,c));return n.flatMap(({pair:c,featurePrefix:p,matePrefix:N})=>f(p).flatMap(d=>f(N).flatMap(h=>u(h,d).map(y=>C({chain:y,target:d,query:h,assemblyName:c.queryAssemblyName,refName:W(d.name),mateAssemblyName:c.targetAssemblyName})))))}getFeatures(e,t={}){return H(async a=>{let s=e.assemblyName===this.anchor?await this.refNames.resolve(e,t):void 0;if(s!==void 0){let n=U(t),o=n.length>0?await this.pairFeatures(s,e,n,t):await this.anchorFeatures(s,e,t);for(let l of o)a.next(l)}a.complete()},t.signal)}};export{L as default};
+//# sourceMappingURL=WalkTabixSyntenyAdapter-ZJJ4SQHH.js.map

package/dist/chunks/WalkTabixSyntenyAdapter-ZJJ4SQHH.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../../src/WalkTabixSyntenyAdapter/walkLanes.ts", "../../src/WalkTabixSyntenyAdapter/WalkTabixSyntenyAdapter.ts"],
+  "sourcesContent": ["import { weightedLcs } from '@gmod/gbz-base/lcs'\nimport { pairAlignments, pairCigar } from '@gmod/gbz-base/pairAlignment'\nimport { panSNContig } from '@jbrowse/bandage-core/pansn'\n\nimport { matchFeature } from '../synteny/matchFeature.ts'\n\nimport type { PairChain, PairEdit } from '@gmod/gbz-base/pairAlignment'\nimport type { WalkFragment, WalkNode } from '@jbrowse/graph-walks'\n\n// The longest bubble with equal bases on both sides that is written as\n// mismatches; a longer one stays an insertion and a deletion\nconst BALANCED_BUBBLE_MAX_BP = 50\n\n/**\n * A chain's edits with each short balanced bubble as `X`. The walks carry no\n * bases, so two walks differ wherever they leave a shared node, and a SNP is\n * one base inserted and one deleted until it is read as the mismatch it is.\n */\nexport function bubblesAsMismatches(edits: PairEdit[]) {\n  const out: PairEdit[] = []\n  for (let i = 0; i < edits.length; i++) {\n    const [op, len] = edits[i]!\n    const [nextOp, nextLen] = edits[i + 1] ?? []\n    if (\n      len === nextLen &&\n      len <= BALANCED_BUBBLE_MAX_BP &&\n      ((op === 'I' && nextOp === 'D') || (op === 'D' && nextOp === 'I'))\n    ) {\n      out.push(['X', len])\n      i++\n    } else {\n      out.push([op, len])\n    }\n  }\n  return out\n}\n\n// A walk's steps as the handles gbz-base reads, 2 * id + reversed\nfunction handlesOf(fragment: WalkFragment) {\n  return Array.from(fragment.ids, (id, i) => 2 * id + fragment.rev[i]!)\n}\n\nfunction nodeLength(nodes: Map<number, WalkNode>, id: number) {\n  const node = nodes.get(id)\n  return node === undefined ? 0 : node.end - node.start\n}\n\n/**\n * Aligns one walk fragment to another on the nodes both visit, from node\n * lengths alone: the fragments' steps as the handles gbz-base's chainer reads,\n * and a stand-in sequence of each node's length.\n */\nexport function walkAligner(nodes: Map<number, WalkNode>) {\n  const standIn = new Map<number, string>()\n  const sequenceOf = (id: number) => {\n    const length = nodeLength(nodes, id)\n    let sequence = standIn.get(length)\n    if (sequence === undefined) {\n      sequence = 'N'.repeat(length)\n      standIn.set(length, sequence)\n    }\n    return sequence\n  }\n  const handles = new Map<WalkFragment, number[]>()\n  const cachedHandles = (fragment: WalkFragment) => {\n    let steps = handles.get(fragment)\n    if (steps === undefined) {\n      steps = handlesOf(fragment)\n      handles.set(fragment, steps)\n    }\n    return steps\n  }\n  return (query: WalkFragment, target: WalkFragment) =>\n    pairAlignments({\n      query: cachedHandles(query),\n      target: cachedHandles(target),\n      sequenceOf,\n      bases: false,\n    })\n}\n\n// The fewest bases on shared nodes a record against the reference keeps,\n// gbz-base's floor for a pair record\nconst MIN_MATCH_BP = 100\n\nfunction appendEdit(edits: PairEdit[], op: PairEdit[0], len: number) {\n  const last = edits.at(-1)\n  if (len > 0) {\n    if (last?.[0] === op) {\n      last[1] += len\n    } else {\n      edits.push([op, len])\n    }\n  }\n}\n\n/**\n * Aligns a haplotype's walk fragment to the reference's as gbz-base aligns a\n * walk to its reference path: the heaviest common subsequence of their steps,\n * each node weighing its length, read in whichever direction shares more. A\n * pair chain leaves out every node either walk passes twice, which is the\n * whole of a collapsed copy-number array (amylase, KIV-2); the subsequence\n * matches one pass over it, and the other copies are insertions.\n */\nexport function referenceAligner(nodes: Map<number, WalkNode>) {\n  const lengthOf = (handle: number) => nodeLength(nodes, handle >> 1)\n  const offsets = (handles: number[]) => {\n    const out = new Float64Array(handles.length + 1)\n    handles.forEach((handle, i) => {\n      out[i + 1] = out[i]! + lengthOf(handle)\n    })\n    return out\n  }\n\n  return (query: WalkFragment, target: WalkFragment): PairChain[] => {\n    const ref = handlesOf(target)\n    const hap = handlesOf(query)\n    const [same, sameWeight] = weightedLcs(hap, ref, lengthOf)\n    const [turned, turnedWeight] = weightedLcs(\n      hap.map(handle => handle ^ 1).reverse(),\n      ref,\n      lengthOf,\n    )\n    const reverse = turnedWeight > sameWeight\n    const pairs = reverse ? turned : same\n    const sharedBases = Math.max(sameWeight, turnedWeight)\n    if (sharedBases < MIN_MATCH_BP) {\n      return []\n    }\n    const refAt = offsets(ref)\n    const hapAt = offsets(hap)\n    // a pair's haplotype step, counted along the haplotype\n    const stepOf = (k: number) =>\n      reverse ? hap.length - 1 - pairs[k]![0] : pairs[k]![0]\n    const edits: PairEdit[] = []\n    pairs.forEach(([, r], k) => {\n      if (k > 0) {\n        const [lo, hi] = [stepOf(k - 1), stepOf(k)].sort((x, y) => x - y)\n        appendEdit(edits, 'I', hapAt[hi!]! - hapAt[lo! + 1]!)\n        appendEdit(edits, 'D', refAt[r]! - refAt[pairs[k - 1]![1] + 1]!)\n      }\n      appendEdit(edits, '=', lengthOf(ref[r]!))\n    })\n    const [lo, hi] = [stepOf(0), stepOf(pairs.length - 1)].sort((x, y) => x - y)\n    return [\n      {\n        queryStart: hapAt[lo!]!,\n        queryEnd: hapAt[hi! + 1]!,\n        targetStart: refAt[pairs[0]![1]]!,\n        targetEnd: refAt[pairs.at(-1)![1] + 1]!,\n        strand: reverse ? '-' : '+',\n        edits,\n        sharedBases,\n      },\n    ]\n  }\n}\n\n// Each node a walk visits once, with the direction it passes it\nfunction singleVisits(fragment: WalkFragment) {\n  const rev = new Map<number, number>()\n  const twice = new Set<number>()\n  fragment.ids.forEach((id, i) => {\n    if (rev.has(id)) {\n      twice.add(id)\n    } else {\n      rev.set(id, fragment.rev[i]!)\n    }\n  })\n  for (const id of twice) {\n    rev.delete(id)\n  }\n  return rev\n}\n\n// The bases on singly visited nodes two walks pass the same way and the\n// opposite way\nfunction directionShares(nodes: Map<number, WalkNode>) {\n  const visits = new Map<WalkFragment, Map<number, number>>()\n  const visitsOf = (fragment: WalkFragment) => {\n    let found = visits.get(fragment)\n    if (found === undefined) {\n      found = singleVisits(fragment)\n      visits.set(fragment, found)\n    }\n    return found\n  }\n  return (query: WalkFragment, target: WalkFragment) => {\n    const theirs = visitsOf(target)\n    let same = 0\n    let opposite = 0\n    for (const [id, rev] of visitsOf(query)) {\n      const other = theirs.get(id)\n      if (other === rev) {\n        same += nodeLength(nodes, id)\n      } else if (other !== undefined) {\n        opposite += nodeLength(nodes, id)\n      }\n    }\n    return { same, opposite }\n  }\n}\n\n/**\n * Aligns one lane's walk fragment to another's. The weighted subsequence\n * (`referenceAligner`) is the fast route and matches through copy-number\n * arrays, but it reads one direction per pair, so an inversion between the\n * lanes comes out as an insertion beside a deletion. A pair sharing 100 bp\n * (MIN_MATCH_BP) or more of singly visited nodes in each direction goes to\n * pair chaining (`walkAligner`) instead, which answers the inverted stretch as\n * a reverse-strand record of its own. Chaining leaves out every node a walk\n * passes twice, so counting singly visited nodes misses no inversion it could\n * draw.\n */\nexport function lanePairAligner(nodes: Map<number, WalkNode>) {\n  const subsequence = referenceAligner(nodes)\n  const chained = walkAligner(nodes)\n  const shares = directionShares(nodes)\n  return (query: WalkFragment, target: WalkFragment) => {\n    const { same, opposite } = shares(query, target)\n    return same >= MIN_MATCH_BP && opposite >= MIN_MATCH_BP\n      ? chained(query, target)\n      : subsequence(query, target)\n  }\n}\n\n// The multi-way display's SPLIT_AT_GAP_BP, under which a turned stretch names\n// no inversion there\nconst TURNED_MIN_BP = 10_000\n\n/**\n * Aligns a haplotype's walk fragment to the reference's as `referenceAligner`\n * does, then adds the stretches it reads the other way. A walk sharing\n * TURNED_MIN_BP or more of singly visited nodes in each direction is chained\n * too, and the chained records on the strand the subsequence did not take are\n * its turned stretches. The subsequence record stays, so a copy-number array,\n * which chaining leaves out, still matches one pass alike in every lane.\n */\nexport function anchorAligner(nodes: Map<number, WalkNode>) {\n  const subsequence = referenceAligner(nodes)\n  const chained = walkAligner(nodes)\n  const shares = directionShares(nodes)\n  return (query: WalkFragment, target: WalkFragment) => {\n    const records = subsequence(query, target)\n    const taken = records[0]?.strand\n    const { same, opposite } = shares(query, target)\n    return taken === undefined || Math.min(same, opposite) < TURNED_MIN_BP\n      ? records\n      : [\n          ...records,\n          ...chained(query, target).filter(chain => chain.strand !== taken),\n        ]\n  }\n}\n\n/**\n * One record of a walk aligned to another, with its short balanced bubbles as\n * mismatches\n */\nexport function chainFeature({\n  chain,\n  target,\n  query,\n  assemblyName,\n  refName,\n  mateAssemblyName,\n}: {\n  chain: PairChain\n  target: WalkFragment\n  query: WalkFragment\n  assemblyName: string\n  refName: string\n  mateAssemblyName: string\n}) {\n  const edits = bubblesAsMismatches(chain.edits)\n  return matchFeature({\n    target: {\n      name: target.name,\n      assemblyName,\n      refName,\n      start: target.hapStart + chain.targetStart,\n      end: target.hapStart + chain.targetEnd,\n    },\n    query: {\n      name: query.name,\n      assemblyName: mateAssemblyName,\n      refName: panSNContig(query.name),\n      start: query.hapStart + chain.queryStart,\n      end: query.hapStart + chain.queryEnd,\n    },\n    strand: chain.strand,\n    cigar: pairCigar(edits),\n    matches: edits.reduce((sum, [op, n]) => sum + (op === '=' ? n : 0), 0),\n    columns: edits.reduce((sum, [, n]) => sum + n, 0),\n  })\n}\n", "import {\n  assemblyByPanSNPrefix,\n  panSNContig,\n  panSNHaplotype,\n  panSNMatchesPrefix,\n  panSNSample,\n  resolvePanSNPrefix,\n} from '@jbrowse/bandage-core/pansn'\nimport { updateStatus } from '@jbrowse/core/util'\nimport { ObservableCreate } from '@jbrowse/core/util/rxjs'\nimport { walksKept } from '@jbrowse/graph-walks'\n\nimport { anchorAligner, chainFeature, lanePairAligner } from './walkLanes.ts'\nimport { WalkIndex } from '../RgfaTabixAdapter/walkReader.ts'\nimport { PanSNRefNames, openTabixSlot } from '../panSNTabix.ts'\nimport { ComparativeAdapterBase } from '../synteny/ComparativeAdapterBase.ts'\nimport {\n  laneAssemblyName,\n  lanePairsStatus,\n  requestedPairs,\n} from '../synteny/lanePairs.ts'\nimport { laneZoomNotice } from '../synteny/laneZoomNotice.ts'\n\nimport type { WalkTabixSyntenyAdapterConfig } from './configSchema.ts'\nimport type { SubgraphAdapterOptions } from '../GetSubgraph.ts'\nimport type { LaneFeatureOptions, LanePair } from '../synteny/lanePairs.ts'\nimport type { BaseOptions } from '@jbrowse/core/data_adapters/BaseAdapter'\nimport type { Feature } from '@jbrowse/core/util'\nimport type { Region } from '@jbrowse/core/util/types'\nimport type { WalkFragment } from '@jbrowse/graph-walks'\n\nconst haplotypeOf = (fragment: WalkFragment) =>\n  panSNHaplotype(fragment.name) ?? fragment.name\n\nexport default class WalkTabixSyntenyAdapter extends ComparativeAdapterBase<WalkTabixSyntenyAdapterConfig> {\n  private readonly walks: WalkIndex = new WalkIndex(\n    openTabixSlot(this, ['walksLocation'], ['walksIndex']),\n    this,\n  )\n  private readonly refNames: PanSNRefNames = new PanSNRefNames(\n    this.walks.file,\n    this,\n  )\n\n  private get anchor() {\n    const anchor = this.getConf('assemblyNames')[0]\n    if (anchor === undefined) {\n      throw new Error(\n        'WalkTabixSyntenyAdapter needs assemblyNames: its first entry is the assembly the reference sample is loaded as',\n      )\n    }\n    return anchor\n  }\n\n  /**\n   * The haplotypes the walk file's header names, `sample#haplotype` in byte\n   * order, or undefined when it names none\n   */\n  async getHaplotypeNames(opts: BaseOptions = {}) {\n    return this.walks.haplotypeNames(opts)\n  }\n\n  /**\n   * `lanes` is every haplotype the header names but the anchor's own,\n   * declared up front so the display can offer the whole graph's haplotypes\n   * before a fetch has placed any of them\n   */\n  async getHeader(opts: BaseOptions = {}) {\n    const { haplotypes } = await this.walks.reader.header(opts)\n    const { anchor } = this\n    const anchorPrefix = resolvePanSNPrefix(this, anchor)\n    const asmByPrefix = assemblyByPanSNPrefix(this)\n    return {\n      hasCoarseTier: false,\n      anchorAssemblyName: anchor,\n      lanes: haplotypes\n        .filter(\n          prefix =>\n            prefix !== anchorPrefix && panSNSample(prefix) !== anchorPrefix,\n        )\n        .map(prefix => ({\n          name: laneAssemblyName(asmByPrefix, prefix),\n          label: prefix,\n          group: panSNSample(prefix),\n        })),\n    }\n  }\n\n  // A lane's contigs are named only in its walk rows, so only the anchor's\n  // are listed\n  async getRefNames(opts: BaseOptions = {}) {\n    const { assemblyName } = opts\n    return assemblyName === undefined || assemblyName === this.anchor\n      ? this.refNames.assemblyRefNames({ ...opts, assemblyName: this.anchor })\n      : []\n  }\n\n  /**\n   * The graph display's cut of the window, as RgfaTabixAdapter cuts a\n   * walk-indexed graph: the reference walk first, then the walks `haplotypes`\n   * asks for, and the nodes and links they visit\n   */\n  async getSubgraph(region: Region, opts: SubgraphAdapterOptions = {}) {\n    const refName = await this.refNames.resolve(region, { signal: opts.signal })\n    if (refName === undefined) {\n      throw new Error(\n        `${region.assemblyName} ${region.refName} is not in this graph's index; the graph is cut on ${this.anchor}, mapped to its PanSN prefix in assemblyNameToPanSN`,\n      )\n    }\n    return this.walks.subgraph(refName, region, opts)\n  }\n\n  // The window's walks for the haplotypes named and the reference, with no\n  // link read; a window past a budget fails as a zoom-in notice for lanes\n  private async laneWalks(\n    refName: string,\n    region: Region,\n    prefixes: string[] | undefined,\n    opts: LaneFeatureOptions,\n    status: string,\n  ) {\n    return updateStatus(status, opts.statusCallback, () =>\n      this.walks.reader\n        .cut(refName, region, {\n          ...this.walks.budgets(),\n          signal: opts.signal,\n          keep: walksKept(prefixes, refName),\n          links: false,\n        })\n        .catch((error: unknown) => {\n          throw laneZoomNotice(error, region.end - region.start)\n        }),\n    )\n  }\n\n  /**\n   * One record per stretch a haplotype's walk shares with the reference's,\n   * on the reference with the haplotype as its mate\n   */\n  private async anchorFeatures(\n    refName: string,\n    region: Region,\n    opts: LaneFeatureOptions,\n  ) {\n    const wanted = opts.haplotypes?.length\n      ? opts.haplotypes.map(lane => resolvePanSNPrefix(this, lane))\n      : undefined\n    const target = resolvePanSNPrefix(this, opts.targetAssemblyName)\n    const prefixes =\n      target === undefined\n        ? wanted\n        : wanted === undefined ||\n            wanted.some(\n              prefix =>\n                panSNMatchesPrefix(target, prefix) ||\n                panSNMatchesPrefix(prefix, target),\n            )\n          ? [target]\n          : []\n    if (prefixes?.length === 0) {\n      return []\n    }\n    const { start, end } = region\n    const { graph, fragments } = await this.laneWalks(\n      refName,\n      region,\n      prefixes,\n      opts,\n      `Reading walks ${region.refName}:${start.toLocaleString()}-${end.toLocaleString()}`,\n    )\n    const align = anchorAligner(graph.nodes)\n    const asmByPrefix = assemblyByPanSNPrefix(this)\n    const references = fragments.filter(f => f.name === refName)\n    // lanes come back in the order the fetch names them, which is the order\n    // the display stacks lanes of equal weight in\n    const rank = (fragment: WalkFragment) =>\n      prefixes === undefined\n        ? 0\n        : prefixes.findIndex(prefix =>\n            panSNMatchesPrefix(fragment.name, prefix),\n          )\n    const shown = fragments\n      .filter(fragment => fragment.name !== refName && rank(fragment) >= 0)\n      .sort((a, b) => rank(a) - rank(b))\n    return shown.flatMap(query =>\n      references.flatMap(reference =>\n        align(query, reference).map(chain =>\n          chainFeature({\n            chain,\n            target: reference,\n            query,\n            assemblyName: region.assemblyName,\n            refName: region.refName,\n            mateAssemblyName: laneAssemblyName(asmByPrefix, haplotypeOf(query)),\n          }),\n        ),\n      ),\n    )\n  }\n\n  /**\n   * Each pair's two lanes read out of the anchor window, all pairs in one\n   * read, and each walk of a pair's query lane aligned to each walk of its\n   * target lane. A pair's records sit on its query lane's contigs, the lane\n   * the display draws on top.\n   */\n  private async pairFeatures(\n    refName: string,\n    region: Region,\n    pairs: LanePair[],\n    opts: LaneFeatureOptions,\n  ) {\n    const sides = pairs.map(pair => ({\n      pair,\n      featurePrefix: resolvePanSNPrefix(this, pair.queryAssemblyName),\n      matePrefix: resolvePanSNPrefix(this, pair.targetAssemblyName),\n    }))\n    const { graph, fragments } = await this.laneWalks(\n      refName,\n      region,\n      sides.flatMap(side => [side.featurePrefix, side.matePrefix]),\n      opts,\n      lanePairsStatus(pairs),\n    )\n    const align = lanePairAligner(graph.nodes)\n    const walksOf = (prefix: string) =>\n      fragments.filter(f => panSNMatchesPrefix(f.name, prefix))\n    return sides.flatMap(({ pair, featurePrefix, matePrefix }) =>\n      walksOf(featurePrefix).flatMap(target =>\n        walksOf(matePrefix).flatMap(query =>\n          align(query, target).map(chain =>\n            chainFeature({\n              chain,\n              target,\n              query,\n              assemblyName: pair.queryAssemblyName,\n              refName: panSNContig(target.name),\n              mateAssemblyName: pair.targetAssemblyName,\n            }),\n          ),\n        ),\n      ),\n    )\n  }\n\n  // The files are filed under the reference alone, so a window on a\n  // haplotype lane has no answer: a lane pair is read inside the anchor's\n  getFeatures(region: Region, opts: LaneFeatureOptions = {}) {\n    return ObservableCreate<Feature>(async observer => {\n      const refName =\n        region.assemblyName === this.anchor\n          ? await this.refNames.resolve(region, opts)\n          : undefined\n      if (refName !== undefined) {\n        const pairs = requestedPairs(opts)\n        const features =\n          pairs.length > 0\n            ? await this.pairFeatures(refName, region, pairs, opts)\n            : await this.anchorFeatures(refName, region, opts)\n        for (const feature of features) {\n          observer.next(feature)\n        }\n      }\n      observer.complete()\n    }, opts.signal)\n  }\n}\n"],
+  "mappings": 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+  "names": ["BALANCED_BUBBLE_MAX_BP", "bubblesAsMismatches", "edits", "out", "i", "op", "len", "nextOp", "nextLen", "handlesOf", "fragment", "id", "nodeLength", "nodes", "node", "walkAligner", "standIn", "sequenceOf", "length", "sequence", "handles", "cachedHandles", "steps", "query", "target", "pairAlignments", "MIN_MATCH_BP", "appendEdit", "last", "referenceAligner", "lengthOf", "handle", "offsets", "ref", "hap", "same", "sameWeight", "weightedLcs", "turned", "turnedWeight", "reverse", "pairs", "sharedBases", "refAt", "hapAt", "stepOf", "k", "r", "lo", "hi", "x", "y", "singleVisits", "rev", "twice", "directionShares", "visits", "visitsOf", "found", "theirs", "opposite", "other", "lanePairAligner", "subsequence", "chained", "shares", "TURNED_MIN_BP", "anchorAligner", "records", "taken", "chain", "chainFeature", "assemblyName", "refName", "mateAssemblyName", "matchFeature", "panSNContig", "pairCigar", "sum", "n", "haplotypeOf", "fragment", "panSNHaplotype", "WalkTabixSyntenyAdapter", "ComparativeAdapterBase", "WalkIndex", "openTabixSlot", "PanSNRefNames", "anchor", "opts", "haplotypes", "anchorPrefix", "resolvePanSNPrefix", "asmByPrefix", "assemblyByPanSNPrefix", "prefix", "panSNSample", "laneAssemblyName", "assemblyName", "region", "refName", "prefixes", "status", "updateStatus", "walksKept", "error", "laneZoomNotice", "wanted", "lane", "target", "panSNMatchesPrefix", "start", "end", "graph", "fragments", "align", "anchorAligner", "references", "f", "rank", "a", "query", "reference", "chain", "chainFeature", "pairs", "sides", "pair", "side", "lanePairsStatus", "lanePairAligner", "walksOf", "featurePrefix", "matePrefix", "panSNContig", "ObservableCreate", "observer", "requestedPairs", "features", "feature"]
+}

package/dist/chunks/chunk-BKBH3WGW.js

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A,n,i,r,o,s,Q,a,g,d,f,I,c,N,h,p,k,D,B,m,u,E,C,l,w;A=t.state,n=t.next_in,l=t.input,i=n+(t.avail_in-5),r=t.next_out,w=t.output,o=r-(e-t.avail_out),s=r+(t.avail_out-257),Q=A.dmax,a=A.wsize,g=A.whave,d=A.wnext,f=A.window,I=A.hold,c=A.bits,N=A.lencode,h=A.distcode,p=(1<<A.lenbits)-1,k=(1<<A.distbits)-1;A:do{c<15&&(I+=l[n++]<<c,c+=8,I+=l[n++]<<c,c+=8),D=N[I&p];e:for(;;){if(B=D>>>24,I>>>=B,c-=B,B=D>>>16&255,B===0)w[r++]=D&65535;else if(B&16){m=D&65535,B&=15,B&&(c<B&&(I+=l[n++]<<c,c+=8),m+=I&(1<<B)-1,I>>>=B,c-=B),c<15&&(I+=l[n++]<<c,c+=8,I+=l[n++]<<c,c+=8),D=h[I&k];t:for(;;){if(B=D>>>24,I>>>=B,c-=B,B=D>>>16&255,B&16){if(u=D&65535,B&=15,c<B&&(I+=l[n++]<<c,c+=8,c<B&&(I+=l[n++]<<c,c+=8)),u+=I&(1<<B)-1,u>Q){t.msg="invalid distance too far back",A.mode=se;break A}if(I>>>=B,c-=B,B=r-o,u>B){if(B=u-B,B>g&&A.sane){t.msg="invalid distance too far back",A.mode=se;break A}if(E=0,C=f,d===0){if(E+=a-B,B<m){m-=B;do w[r++]=f[E++];while(--B);E=r-u,C=w}}else if(d<B){if(E+=a+d-B,B-=d,B<m){m-=B;do w[r++]=f[E++];while(--B);if(E=0,d<m){B=d,m-=B;do w[r++]=f[E++];while(--B);E=r-u,C=w}}}else if(E+=d-B,B<m){m-=B;do w[r++]=f[E++];while(--B);E=r-u,C=w}for(;m>2;)w[r++]=C[E++],w[r++]=C[E++],w[r++]=C[E++],m-=3;m&&(w[r++]=C[E++],m>1&&(w[r++]=C[E++]))}else{E=r-u;do w[r++]=w[E++],w[r++]=w[E++],w[r++]=w[E++],m-=3;while(m>2);m&&(w[r++]=w[E++],m>1&&(w[r++]=w[E++]))}}else if((B&64)===0){D=h[(D&65535)+(I&(1<<B)-1)];continue t}else{t.msg="invalid distance code",A.mode=se;break A}break}}else if((B&64)===0){D=N[(D&65535)+(I&(1<<B)-1)];continue e}else if(B&32){A.mode=nr;break A}else{t.msg="invalid literal/length code",A.mode=se;break A}break}}while(n<i&&r<s);m=c>>3,n-=m,c-=m<<3,I&=(1<<c)-1,t.next_in=n,t.next_out=r,t.avail_in=n<i?5+(i-n):5-(n-i),t.avail_out=r<s?257+(s-r):257-(r-s),A.hold=I,A.bits=c}var DA=15,ln=852,hn=592,dn=0,nt=1,un=2,ir=[3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0],rr=[16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78],or=[1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0],sr=[16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64];function BA(t,e,A,n,i,r,o,s){var Q=s.bits,a=0,g=0,d=0,f=0,I=0,c=0,N=0,h=0,p=0,k=0,D,B,m,u,E,C=null,l=0,w,y=oA(DA+1),x=oA(DA+1),b=null,S=0,R,U,v;for(a=0;a<=DA;a++)y[a]=0;for(g=0;g<n;g++)y[e[A+g]]++;for(I=Q,f=DA;f>=1&&y[f]===0;f--);if(I>f&&(I=f),f===0)return 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ar=0,On=1,Xn=2,wn=4,gr=5,ae=6,EA=0,Ir=1,Qr=2,Z=-2,zn=-3,gt=-4,Cr=-5,pn=8,Pn=1,kn=2,mn=3,Dn=4,Nn=5,yn=6,xn=7,bn=8,Sn=9,Fn=10,Qe=11,AA=12,it=13,Rn=14,rt=15,vn=16,Jn=17,Gn=18,Ln=19,ge=20,Ie=21,Mn=22,_n=23,Un=24,Yn=25,Hn=26,ot=27,Kn=28,Tn=29,G=30,It=31,cr=32,Br=852,Er=592;function qn(t){return(t>>>24&255)+(t>>>8&65280)+((t&65280)<<8)+((t&255)<<24)}function fr(){this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=oA(320),this.work=oA(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}function lr(t){var e;return!t||!t.state?Z:(e=t.state,t.total_in=t.total_out=e.total=0,t.msg="",e.wrap&&(t.adler=e.wrap&1),e.mode=Pn,e.last=0,e.havedict=0,e.dmax=32768,e.head=null,e.hold=0,e.bits=0,e.lencode=e.lendyn=cA(Br),e.distcode=e.distdyn=cA(Er),e.sane=1,e.back=-1,EA)}function hr(t){var e;return!t||!t.state?Z:(e=t.state,e.wsize=0,e.whave=0,e.wnext=0,lr(t))}function dr(t,e){var A,n;return!t||!t.state||(n=t.state,e<0?(A=0,e=-e):(A=(e>>4)+1,e<48&&(e&=15)),e&&(e<8||e>15))?Z:(n.window!==null&&n.wbits!==e&&(n.window=null),n.wrap=A,n.wbits=e,hr(t))}function jn(t,e){var A,n;return t?(n=new fr,t.state=n,n.window=null,A=dr(t,e),A!==EA&&(t.state=null),A):Z}var Zn=!0,st,at;function ur(t){if(Zn){var e;for(st=cA(512),at=cA(32),e=0;e<144;)t.lens[e++]=8;for(;e<256;)t.lens[e++]=9;for(;e<280;)t.lens[e++]=7;for(;e<288;)t.lens[e++]=8;for(BA(On,t.lens,0,288,st,0,t.work,{bits:9}),e=0;e<32;)t.lens[e++]=5;BA(Xn,t.lens,0,32,at,0,t.work,{bits:5}),Zn=!1}t.lencode=st,t.lenbits=9,t.distcode=at,t.distbits=5}function Wn(t,e,A,n){var i,r=t.state;return r.window===null&&(r.wsize=1<<r.wbits,r.wnext=0,r.whave=0,r.window=$(r.wsize)),n>=r.wsize?(j(r.window,e,A-r.wsize,r.wsize,0),r.wnext=0,r.whave=r.wsize):(i=r.wsize-r.wnext,i>n&&(i=n),j(r.window,e,A-n,i,r.wnext),n-=i,n?(j(r.window,e,A-n,n,0),r.wnext=n,r.whave=r.wsize):(r.wnext+=i,r.wnext===r.wsize&&(r.wnext=0),r.whave<r.wsize&&(r.whave+=i))),0}function Vn(t,e){var A,n,i,r,o,s,Q,a,g,d,f,I,c,N,h=0,p,k,D,B,m,u,E,C,l=$(4),w,y,x=[16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15];if(!t||!t.state||!t.output||!t.input&&t.avail_in!==0)return Z;A=t.state,A.mode===AA&&(A.mode=it),o=t.next_out,i=t.output,Q=t.avail_out,r=t.next_in,n=t.input,s=t.avail_in,a=A.hold,g=A.bits,d=s,f=Q,C=EA;A:for(;;)switch(A.mode){case Pn:if(A.wrap===0){A.mode=it;break}for(;g<16;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}if(A.wrap&2&&a===35615){A.check=0,l[0]=a&255,l[1]=a>>>8&255,A.check=q(A.check,l,2,0),a=0,g=0,A.mode=kn;break}if(A.flags=0,A.head&&(A.head.done=!1),!(A.wrap&1)||(((a&255)<<8)+(a>>8))%31){t.msg="incorrect header check",A.mode=G;break}if((a&15)!==pn){t.msg="unknown compression method",A.mode=G;break}if(a>>>=4,g-=4,E=(a&15)+8,A.wbits===0)A.wbits=E;else if(E>A.wbits){t.msg="invalid window size",A.mode=G;break}A.dmax=1<<E,t.adler=A.check=1,A.mode=a&512?Fn:AA,a=0,g=0;break;case kn:for(;g<16;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}if(A.flags=a,(A.flags&255)!==pn){t.msg="unknown compression method",A.mode=G;break}if(A.flags&57344){t.msg="unknown header flags set",A.mode=G;break}A.head&&(A.head.text=a>>8&1),A.flags&512&&(l[0]=a&255,l[1]=a>>>8&255,A.check=q(A.check,l,2,0)),a=0,g=0,A.mode=mn;case mn:for(;g<32;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}A.head&&(A.head.time=a),A.flags&512&&(l[0]=a&255,l[1]=a>>>8&255,l[2]=a>>>16&255,l[3]=a>>>24&255,A.check=q(A.check,l,4,0)),a=0,g=0,A.mode=Dn;case Dn:for(;g<16;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}A.head&&(A.head.xflags=a&255,A.head.os=a>>8),A.flags&512&&(l[0]=a&255,l[1]=a>>>8&255,A.check=q(A.check,l,2,0)),a=0,g=0,A.mode=Nn;case Nn:if(A.flags&1024){for(;g<16;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}A.length=a,A.head&&(A.head.extra_len=a),A.flags&512&&(l[0]=a&255,l[1]=a>>>8&255,A.check=q(A.check,l,2,0)),a=0,g=0}else A.head&&(A.head.extra=null);A.mode=yn;case yn:if(A.flags&1024&&(I=A.length,I>s&&(I=s),I&&(A.head&&(E=A.head.extra_len-A.length,A.head.extra||(A.head.extra=new Array(A.head.extra_len)),j(A.head.extra,n,r,I,E)),A.flags&512&&(A.check=q(A.check,n,I,r)),s-=I,r+=I,A.length-=I),A.length))break A;A.length=0,A.mode=xn;case xn:if(A.flags&2048){if(s===0)break A;I=0;do E=n[r+I++],A.head&&E&&A.length<65536&&(A.head.name+=String.fromCharCode(E));while(E&&I<s);if(A.flags&512&&(A.check=q(A.check,n,I,r)),s-=I,r+=I,E)break A}else A.head&&(A.head.name=null);A.length=0,A.mode=bn;case bn:if(A.flags&4096){if(s===0)break A;I=0;do E=n[r+I++],A.head&&E&&A.length<65536&&(A.head.comment+=String.fromCharCode(E));while(E&&I<s);if(A.flags&512&&(A.check=q(A.check,n,I,r)),s-=I,r+=I,E)break A}else A.head&&(A.head.comment=null);A.mode=Sn;case Sn:if(A.flags&512){for(;g<16;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}if(a!==(A.check&65535)){t.msg="header crc mismatch",A.mode=G;break}a=0,g=0}A.head&&(A.head.hcrc=A.flags>>9&1,A.head.done=!0),t.adler=A.check=0,A.mode=AA;break;case Fn:for(;g<32;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}t.adler=A.check=qn(a),a=0,g=0,A.mode=Qe;case Qe:if(A.havedict===0)return t.next_out=o,t.avail_out=Q,t.next_in=r,t.avail_in=s,A.hold=a,A.bits=g,Qr;t.adler=A.check=1,A.mode=AA;case AA:if(e===gr||e===ae)break A;case it:if(A.last){a>>>=g&7,g-=g&7,A.mode=ot;break}for(;g<3;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}switch(A.last=a&1,a>>>=1,g-=1,a&3){case 0:A.mode=Rn;break;case 1:if(ur(A),A.mode=ge,e===ae){a>>>=2,g-=2;break A}break;case 2:A.mode=Jn;break;case 3:t.msg="invalid block type",A.mode=G}a>>>=2,g-=2;break;case Rn:for(a>>>=g&7,g-=g&7;g<32;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}if((a&65535)!==(a>>>16^65535)){t.msg="invalid stored block lengths",A.mode=G;break}if(A.length=a&65535,a=0,g=0,A.mode=rt,e===ae)break A;case rt:A.mode=vn;case vn:if(I=A.length,I){if(I>s&&(I=s),I>Q&&(I=Q),I===0)break A;j(i,n,r,I,o),s-=I,r+=I,Q-=I,o+=I,A.length-=I;break}A.mode=AA;break;case Jn:for(;g<14;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}if(A.nlen=(a&31)+257,a>>>=5,g-=5,A.ndist=(a&31)+1,a>>>=5,g-=5,A.ncode=(a&15)+4,a>>>=4,g-=4,A.nlen>286||A.ndist>30){t.msg="too many length or distance symbols",A.mode=G;break}A.have=0,A.mode=Gn;case Gn:for(;A.have<A.ncode;){for(;g<3;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}A.lens[x[A.have++]]=a&7,a>>>=3,g-=3}for(;A.have<19;)A.lens[x[A.have++]]=0;if(A.lencode=A.lendyn,A.lenbits=7,w={bits:A.lenbits},C=BA(ar,A.lens,0,19,A.lencode,0,A.work,w),A.lenbits=w.bits,C){t.msg="invalid code lengths set",A.mode=G;break}A.have=0,A.mode=Ln;case Ln:for(;A.have<A.nlen+A.ndist;){for(;h=A.lencode[a&(1<<A.lenbits)-1],p=h>>>24,k=h>>>16&255,D=h&65535,!(p<=g);){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}if(D<16)a>>>=p,g-=p,A.lens[A.have++]=D;else{if(D===16){for(y=p+2;g<y;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}if(a>>>=p,g-=p,A.have===0){t.msg="invalid bit length repeat",A.mode=G;break}E=A.lens[A.have-1],I=3+(a&3),a>>>=2,g-=2}else if(D===17){for(y=p+3;g<y;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}a>>>=p,g-=p,E=0,I=3+(a&7),a>>>=3,g-=3}else{for(y=p+7;g<y;){if(s===0)break A;s--,a+=n[r++]<<g,g+=8}a>>>=p,g-=p,E=0,I=11+(a&127),a>>>=7,g-=7}if(A.have+I>A.nlen+A.ndist){t.msg="invalid bit length 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f=we(A,16),I=n.getInt32(16+g,!0),c=16+g+4,N,h=[];for(let k=0;k<I;k++){h.push(c);let D=n.getInt32(c,!0);c+=4;for(let B=0;B<D;B++){let m=n.getUint32(c,!0);if(c+=4,m>Q)c+=44;else{N=ue(A,c,1,N),c+=8;let u=n.getInt32(c,!0);c+=4+16*u}}}function p(k){let D=h[k];if(D===void 0)return;let B=D,m=n.getInt32(B,!0);B+=4;let u={},E={},C;for(let l=0;l<m;l++){let w=n.getUint32(B,!0);if(B+=4,w>Q)C=pe(A,B+28),B+=44;else{E[w]=gA(A,B),B+=8;let y=n.getInt32(B,!0);B+=4;let x=Array.from({length:y});for(let b=0;b<y;b++)x[b]=new W(gA(A,B),gA(A,B+8),w),B+=16;u[w]=x}}return de(Object.values(u).flat()),{binIndex:u,loffsets:E,stats:C}}return{...f,csi:!0,refCount:I,maxBlockSize:65536,firstDataLine:N,csiVersion:r,indices:ke(p),minShift:o,depth:s,maxBinNumber:Q,maxRefLength:a}}lowestOffset(e,A,{minShift:n,depth:i}){let{loffsets:r}=e,o;if(r){let s=(Fi(1,3*i)-1)/7+yt(Math.max(A,0),n);for(;o===void 0&&s>0;)if(o=r[s],o===void 0){let Q=Math.floor((s-1)/8),a=Q*8+1;s=s>a?s-1:Q}o??=r[0]}return 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n=await this.filehandle.read(e.fetchedSize(),e.minv.blockPosition,A);lA(A.signal);let i=await this.bgzfWorkerPool;return ut(n,e,i)}};var oo=t=>({type:"fileLocation",defaultValue:{uri:t,locationType:"UriLocation"}}),wa=(t,e="")=>vt(t,{indexType:{model:Jt.enumeration("IndexType",["TBI","CSI"]),type:"stringEnum",defaultValue:"TBI"},location:oo(e)});function so(t,e,A){return{indexType:A?"CSI":"TBI",location:{uri:`${t}.${A?"csi":"tbi"}`,baseUri:e}}}function pa(t){let{walksUri:e,baseUri:A,csi:n}=t;if(typeof e!="string")return t;let i=`${e}.walks.bed.gz`;return{...t,walksLocation:{uri:i,baseUri:A},walksIndex:so(i,A,n)}}function ka(t,e,A){let n=t.pluginManager;return new bA({filehandle:Gt(t.getConf(e),n),...Lt(t.getConf([...A,"location"]),t.getConf([...A,"indexType"]),n)})}function ao(t){return`${t.assemblyName} ${t.refName} is not in this graph's index; a graph with PanSN names (GRCh38#0#chr1) needs ${t.assemblyName} mapped to its prefix in assemblyNameToPanSN`}var _i=class{constructor(e,A){this.file=e;this.adapter=A;this.lookup=_t({setup:async e=>GA(await this.file.getReferenceSequenceNames(e))})}async assemblyRefNames(e={}){let A=await this.file.getReferenceSequenceNames(e),n=zA(this.adapter,e.assemblyName),i=A.filter(r=>xe(r,n)).map(r=>Rt(r));return i.length>0?[...new Set(i)]:A}async resolve(e,A){let n=await this.lookup(A);return LA(n,zA(this.adapter,e.assemblyName),e.refName)}async resolveMapped(e,A){let n=await this.resolve(e,A);if(n===void 0&&e.assemblyName){let i=await this.file.getReferenceSequenceNames(A),r=zA(this.adapter,e.assemblyName);if(i.every(o=>o.includes("#"))&&!i.some(o=>xe(o,r)))throw new Error(ao(e))}return n}async regionBytes(e,A={},n=async i=>i){let i=[];for(let r of e){let o=await this.resolve(r,A);o!==void 0&&i.push({refName:o,start:await n(r.start),end:r.end})}return sn(this.file,i,A)}};export{TA as a,go as b,_t as c,Hi as d,Me as e,Vi as f,Pe as g,Ze as h,qi as i,$i as j,_o as k,oo as l,wa as m,so as n,pa as o,ka as 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