heor-agent-mcp 1.2.0 → 1.2.1
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/jca/countryRegistry.d.ts.map +1 -1
- package/dist/jca/countryRegistry.js +9 -6
- package/dist/jca/countryRegistry.js.map +1 -1
- package/dist/jca/scopeBuilder.d.ts +1 -3
- package/dist/jca/scopeBuilder.d.ts.map +1 -1
- package/dist/jca/scopeBuilder.js +1 -7
- package/dist/jca/scopeBuilder.js.map +1 -1
- package/dist/jca/types.d.ts +4 -3
- package/dist/jca/types.d.ts.map +1 -1
- package/dist/tools/jcaPicoScope.d.ts +1 -1
- package/dist/tools/jcaPicoScope.d.ts.map +1 -1
- package/dist/tools/jcaPicoScope.js +27 -14
- package/dist/tools/jcaPicoScope.js.map +1 -1
- package/package.json +1 -1
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@@ -1 +1 @@
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1
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-
{"version":3,"file":"countryRegistry.d.ts","sourceRoot":"","sources":["../../src/jca/countryRegistry.ts"],"names":[],"mappings":"AAAA;;;;;;;;;GASG;AACH,OAAO,KAAK,EAEV,cAAc,EAEd,kBAAkB,EAClB,YAAY,EAEZ,eAAe,EAChB,MAAM,YAAY,CAAC;AAEpB,eAAO,MAAM,YAAY,EAAG,SAAkB,CAAC;
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1
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+
{"version":3,"file":"countryRegistry.d.ts","sourceRoot":"","sources":["../../src/jca/countryRegistry.ts"],"names":[],"mappings":"AAAA;;;;;;;;;GASG;AACH,OAAO,KAAK,EAEV,cAAc,EAEd,kBAAkB,EAClB,YAAY,EAEZ,eAAe,EAChB,MAAM,YAAY,CAAC;AAEpB,eAAO,MAAM,YAAY,EAAG,SAAkB,CAAC;AAkL/C,eAAO,MAAM,gBAAgB,EAAE,MAAM,CAAC,YAAY,EAAE,cAAc,CAoBjE,CAAC;AAEF;;;GAGG;AACH,wBAAgB,kBAAkB,CAAC,UAAU,EAAE,MAAM,GAAG,kBAAkB,CAgEzE;AAED,wBAAgB,UAAU,CAAC,YAAY,EAAE,YAAY,GAAG,cAAc,CAErE;AAED,wBAAgB,0BAA0B,CACxC,QAAQ,EAAE,kBAAkB,GAC3B,eAAe,EAAE,CAEnB"}
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@@ -161,8 +161,6 @@ function profile(jurisdiction, hta_body) {
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return {
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jurisdiction,
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hta_body,
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164
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-
outcome_instrument_preferences: ["EQ-5D-5L"],
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165
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-
outcome_priority: ["OS", "PFS", "HRQoL", "AE"],
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comparators: (cat, dc, line) => comparatorsFor(jurisdiction, cat, dc, line),
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population_subgroups: (cat) => subgroupsFor(cat),
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};
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@@ -177,8 +175,6 @@ export const COUNTRY_PROFILES = {
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eu_other: {
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jurisdiction: "eu_other",
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hta_body: "Other EU member states — consult national HTA",
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-
outcome_instrument_preferences: ["EQ-5D-5L"],
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-
outcome_priority: ["OS", "PFS", "HRQoL", "AE"],
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comparators: () => [
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{
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molecule: "consult national HTA body",
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@@ -211,11 +207,18 @@ export function classifyIndication(indication) {
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x.includes("lymphoma")) {
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return "oncology_other";
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}
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-
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+
// "UC" as a bare token is fine; "uc" as a substring is too broad — it
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211
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+
// matches mucositis, Duchenne, glaucoma, etc. Use word boundaries.
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if (x.includes("ulcerative colitis") ||
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/(^|\s)uc(\s|$)/.test(x) ||
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/(^|\s)u\.c\.(\s|$)/.test(x)) {
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return "ibd_uc";
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}
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if (x.includes("crohn"))
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return "ibd_cd";
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-
if (x.includes("type 2 diabetes") ||
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+
if (x.includes("type 2 diabetes") ||
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x.includes("t2d") ||
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x.includes("diabetes mellitus type 2")) {
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return "diabetes_t2";
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}
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if (x.includes("obesity") || x.includes("overweight"))
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@@ -1 +1 @@
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1
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-
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+
{"version":3,"file":"countryRegistry.js","sourceRoot":"","sources":["../../src/jca/countryRegistry.ts"],"names":[],"mappings":"AAoBA,MAAM,CAAC,MAAM,YAAY,GAAG,SAAkB,CAAC;AAE/C,SAAS,cAAc,CAAC,QAA4B;IAClD,IAAI,QAAQ,KAAK,gBAAgB,IAAI,QAAQ,KAAK,gBAAgB,EAAE,CAAC;QACnE,OAAO,CAAC,UAAU,EAAE,eAAe,CAAC,CAAC;IACvC,CAAC;IACD,IAAI,QAAQ,KAAK,QAAQ,IAAI,QAAQ,KAAK,QAAQ,EAAE,CAAC;QACnD,OAAO,CAAC,UAAU,EAAE,SAAS,CAAC,CAAC;IACjC,CAAC;IACD,IAAI,QAAQ,KAAK,aAAa,IAAI,QAAQ,KAAK,SAAS,EAAE,CAAC;QACzD,OAAO,CAAC,UAAU,EAAE,YAAY,CAAC,CAAC;IACpC,CAAC;IACD,OAAO,CAAC,UAAU,CAAC,CAAC;AACtB,CAAC;AAED,SAAS,uBAAuB;IAC9B,OAAO,CAAC,IAAI,EAAE,KAAK,EAAE,OAAO,EAAE,IAAI,CAAC,CAAC;AACtC,CAAC;AAED,SAAS,kBAAkB;IACzB,OAAO,CAAC,WAAW,EAAE,OAAO,EAAE,IAAI,EAAE,OAAO,CAAC,CAAC;AAC/C,CAAC;AAED,SAAS,sBAAsB;IAC7B,OAAO,CAAC,OAAO,EAAE,WAAW,EAAE,IAAI,EAAE,OAAO,CAAC,CAAC;AAC/C,CAAC;AAED,SAAS,kBAAkB,CAAC,QAA4B;IACtD,IAAI,QAAQ,KAAK,gBAAgB,IAAI,QAAQ,KAAK,gBAAgB,EAAE,CAAC;QACnE,OAAO,uBAAuB,EAAE,CAAC;IACnC,CAAC;IACD,IAAI,QAAQ,KAAK,QAAQ,IAAI,QAAQ,KAAK,QAAQ,EAAE,CAAC;QACnD,OAAO,kBAAkB,EAAE,CAAC;IAC9B,CAAC;IACD,OAAO,sBAAsB,EAAE,CAAC;AAClC,CAAC;AAED,SAAS,0BAA0B,CAAC,OAAqB;IACvD,oEAAoE;IACpE,sEAAsE;IACtE,yEAAyE;IACzE,MAAM,WAAW,GAAG,cAAc,CAAC,gBAAgB,CAAC,CAAC;IACrD,MAAM,KAAK,GAAoB;QAC7B,QAAQ,EAAE,0BAA0B;QACpC,SAAS,EAAE,wDAAwD,OAAO,CAAC,WAAW,EAAE,iCAAiC;QACzH,8BAA8B,EAAE,WAAW;KAC5C,CAAC;IACF,MAAM,EAAE,GAAoB;QAC1B,QAAQ,EAAE,eAAe;QACzB,SAAS,EAAE,kHAAkH,OAAO,CAAC,WAAW,EAAE,mBAAmB;QACrK,8BAA8B,EAAE,WAAW;KAC5C,CAAC;IACF,MAAM,OAAO,GAAoB;QAC/B,QAAQ,EAAE,UAAU;QACpB,SAAS,EAAE,4EAA4E,OAAO,CAAC,WAAW,EAAE,GAAG;QAC/G,8BAA8B,EAAE,WAAW;KAC5C,CAAC;IACF,IAAI,OAAO,KAAK,IAAI,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,KAAK,EAAE,EAAE,CAAC,CAAC;IAC7D,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,KAAK,EAAE,OAAO,CAAC,CAAC;IAC9C,IAAI,OAAO,KAAK,IAAI,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,KAAK,EAAE,EAAE,EAAE,OAAO,CAAC,CAAC;IACtE,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,KAAK,EAAE,EAAE,CAAC,CAAC;IACzC,OAAO,CAAC,KAAK,CAAC,CAAC;AACjB,CAAC;AAED,SAAS,wBAAwB,CAAC,OAAqB;IACrD,MAAM,WAAW,GAAG,cAAc,CAAC,QAAQ,CAAC,CAAC;IAC7C,2EAA2E;IAC3E,wDAAwD;IACxD,MAAM,GAAG,GAAoB;QAC3B,QAAQ,EAAE,aAAa;QACvB,SAAS,EAAE,iEAAiE,OAAO,CAAC,WAAW,EAAE,6BAA6B;QAC9H,8BAA8B,EAAE,WAAW;KAC5C,CAAC;IACF,MAAM,GAAG,GAAoB;QAC3B,QAAQ,EAAE,YAAY;QACtB,SAAS,EAAE,4FAA4F,OAAO,CAAC,WAAW,EAAE,GAAG;QAC/H,8BAA8B,EAAE,WAAW;KAC5C,CAAC;IACF,MAAM,GAAG,GAAoB;QAC3B,QAAQ,EAAE,aAAa;QACvB,SAAS,EAAE,qDAAqD;QAChE,8BAA8B,EAAE,WAAW;KAC5C,CAAC;IACF,MAAM,EAAE,GAAoB;QAC1B,QAAQ,EAAE,UAAU;QACpB,SAAS,EAAE,kFAAkF;QAC7F,8BAA8B,EAAE,WAAW;KAC5C,CAAC;IACF,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,GAAG,EAAE,GAAG,EAAE,GAAG,CAAC,CAAC;IAC7C,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,GAAG,EAAE,GAAG,EAAE,EAAE,CAAC,CAAC;IAC5C,IAAI,OAAO,KAAK,IAAI,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,GAAG,EAAE,GAAG,EAAE,GAAG,EAAE,EAAE,CAAC,CAAC;IACrE,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,GAAG,EAAE,GAAG,CAAC,CAAC;IACxC,IAAI,OAAO,KAAK,IAAI;QAAE,OAAO,CAAC,GAAG,EAAE,GAAG,EAAE,GAAG,CAAC,CAAC;IAC7C,OAAO,CAAC,GAAG,EAAE,GAAG,CAAC,CAAC;AACpB,CAAC;AAED,SAAS,kBAAkB,CACzB,OAAqB,EACrB,QAA4B;IAE5B,MAAM,WAAW,GAAG,cAAc,CAAC,QAAQ,CAAC,CAAC;IAC7C,OAAO;QACL;YACE,QAAQ,EAAE,qCAAqC;YAC/C,SAAS,EAAE,+CAA+C,OAAO,CAAC,WAAW,EAAE,0CAA0C;YACzH,8BAA8B,EAAE,WAAW;SAC5C;KACF,CAAC;AACJ,CAAC;AAED,SAAS,cAAc,CACrB,OAAqB,EACrB,QAA4B,EAC5B,UAAqB,EACrB,IAAmB;IAEnB,IAAI,QAAQ,KAAK,gBAAgB,IAAI,IAAI,KAAK,aAAa,EAAE,CAAC;QAC5D,OAAO,0BAA0B,CAAC,OAAO,CAAC,CAAC;IAC7C,CAAC;IACD,IAAI,QAAQ,KAAK,QAAQ,EAAE,CAAC;QAC1B,OAAO,wBAAwB,CAAC,OAAO,CAAC,CAAC;IAC3C,CAAC;IACD,oDAAoD;IACpD,IAAI,QAAQ,KAAK,gBAAgB,IAAI,QAAQ,KAAK,gBAAgB,EAAE,CAAC;QACnE,MAAM,WAAW,GAAG,cAAc,CAAC,QAAQ,CAAC,CAAC;QAC7C,OAAO;YACL;gBACE,QAAQ,EAAE,+BAA+B;gBACzC,SAAS,EAAE,0CAA0C,OAAO,CAAC,WAAW,EAAE,4DAA4D;gBACtI,8BAA8B,EAAE,WAAW;aAC5C;SACF,CAAC;IACJ,CAAC;IACD,KAAK,UAAU,CAAC;IAChB,OAAO,kBAAkB,CAAC,OAAO,EAAE,QAAQ,CAAC,CAAC;AAC/C,CAAC;AAED,SAAS,YAAY,CAAC,QAA4B;IAChD,IAAI,QAAQ,KAAK,gBAAgB,EAAE,CAAC;QAClC,OAAO;YACL,sBAAsB;YACtB,gCAAgC;YAChC,oCAAoC;YACpC,2BAA2B;SAC5B,CAAC;IACJ,CAAC;IACD,IAAI,QAAQ,KAAK,QAAQ,EAAE,CAAC;QAC1B,OAAO;YACL,uCAAuC;YACvC,oDAAoD;YACpD,6CAA6C;SAC9C,CAAC;IACJ,CAAC;IACD,IAAI,QAAQ,KAAK,QAAQ,EAAE,CAAC;QAC1B,OAAO;YACL,2BAA2B;YAC3B,yBAAyB;YACzB,gCAAgC;SACjC,CAAC;IACJ,CAAC;IACD,IAAI,QAAQ,KAAK,aAAa,EAAE,CAAC;QAC/B,OAAO,CAAC,gBAAgB,EAAE,cAAc,EAAE,gBAAgB,CAAC,CAAC;IAC9D,CAAC;IACD,IAAI,QAAQ,KAAK,SAAS,EAAE,CAAC;QAC3B,OAAO,CAAC,cAAc,EAAE,8BAA8B,CAAC,CAAC;IAC1D,CAAC;IACD,OAAO,CAAC,YAAY,EAAE,oBAAoB,CAAC,CAAC;AAC9C,CAAC;AAED,SAAS,OAAO,CAAC,YAA0B,EAAE,QAAgB;IAC3D,OAAO;QACL,YAAY;QACZ,QAAQ;QACR,WAAW,EAAE,CAAC,GAAG,EAAE,EAAE,EAAE,IAAI,EAAE,EAAE,CAAC,cAAc,CAAC,YAAY,EAAE,GAAG,EAAE,EAAE,EAAE,IAAI,CAAC;QAC3E,oBAAoB,EAAE,CAAC,GAAG,EAAE,EAAE,CAAC,YAAY,CAAC,GAAG,CAAC;KACjD,CAAC;AACJ,CAAC;AAED,MAAM,CAAC,MAAM,gBAAgB,GAAyC;IACpE,EAAE,EAAE,OAAO,CAAC,IAAI,EAAE,cAAc,CAAC;IACjC,EAAE,EAAE,OAAO,CAAC,IAAI,EAAE,KAAK,CAAC;IACxB,EAAE,EAAE,OAAO,CAAC,IAAI,EAAE,MAAM,CAAC;IACzB,EAAE,EAAE,OAAO,CAAC,IAAI,EAAE,gBAAgB,CAAC;IACnC,EAAE,EAAE,OAAO,CAAC,IAAI,EAAE,yBAAyB,CAAC;IAC5C,EAAE,EAAE,OAAO,CAAC,IAAI,EAAE,kCAAkC,CAAC;IACrD,QAAQ,EAAE;QACR,YAAY,EAAE,UAAU;QACxB,QAAQ,EAAE,+CAA+C;QACzD,WAAW,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|
|
@@ -1,4 +1,4 @@
|
|
|
1
|
-
import type {
|
|
1
|
+
import type { DrugClass, Jurisdiction, LineOfTherapy, PicoMatrix } from "./types.js";
|
|
2
2
|
export interface ScopeBuilderInput {
|
|
3
3
|
drug: string;
|
|
4
4
|
indication: string;
|
|
@@ -10,6 +10,4 @@ export interface ScopeBuilderInput {
|
|
|
10
10
|
regulatory_context: "pre_authorisation" | "post_authorisation" | "conditional_approval";
|
|
11
11
|
}
|
|
12
12
|
export declare function buildScope(input: ScopeBuilderInput): PicoMatrix;
|
|
13
|
-
/** Lists every comparator molecule a country profile produced — used for the markdown report. */
|
|
14
|
-
export declare function flattenComparators(country_specific: PicoMatrix["country_specific"]): ComparatorEntry[];
|
|
15
13
|
//# sourceMappingURL=scopeBuilder.d.ts.map
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"scopeBuilder.d.ts","sourceRoot":"","sources":["../../src/jca/scopeBuilder.ts"],"names":[],"mappings":"AAUA,OAAO,KAAK,EACV,
|
|
1
|
+
{"version":3,"file":"scopeBuilder.d.ts","sourceRoot":"","sources":["../../src/jca/scopeBuilder.ts"],"names":[],"mappings":"AAUA,OAAO,KAAK,EACV,SAAS,EACT,YAAY,EACZ,aAAa,EACb,UAAU,EACX,MAAM,YAAY,CAAC;AAEpB,MAAM,WAAW,iBAAiB;IAChC,IAAI,EAAE,MAAM,CAAC;IACb,UAAU,EAAE,MAAM,CAAC;IACnB,UAAU,EAAE,SAAS,CAAC;IACtB,mBAAmB,CAAC,EAAE,MAAM,CAAC;IAC7B,eAAe,EAAE,aAAa,CAAC;IAC/B,gBAAgB,CAAC,EAAE,MAAM,CAAC;IAC1B,aAAa,EAAE,YAAY,EAAE,CAAC;IAC9B,kBAAkB,EACd,mBAAmB,GACnB,oBAAoB,GACpB,sBAAsB,CAAC;CAC5B;AAED,wBAAgB,UAAU,CAAC,KAAK,EAAE,iBAAiB,GAAG,UAAU,CA0C/D"}
|
package/dist/jca/scopeBuilder.js
CHANGED
|
@@ -28,6 +28,7 @@ export function buildScope(input) {
|
|
|
28
28
|
return {
|
|
29
29
|
drug: input.drug,
|
|
30
30
|
indication: input.indication,
|
|
31
|
+
indication_category: category,
|
|
31
32
|
jca_revision: JCA_REVISION,
|
|
32
33
|
picos,
|
|
33
34
|
country_specific,
|
|
@@ -79,11 +80,4 @@ function buildRationale(input, category, distinct) {
|
|
|
79
80
|
}
|
|
80
81
|
return parts.join(" ");
|
|
81
82
|
}
|
|
82
|
-
/** Lists every comparator molecule a country profile produced — used for the markdown report. */
|
|
83
|
-
export function flattenComparators(country_specific) {
|
|
84
|
-
const out = [];
|
|
85
|
-
for (const c of country_specific)
|
|
86
|
-
out.push(...c.comparators);
|
|
87
|
-
return out;
|
|
88
|
-
}
|
|
89
83
|
//# sourceMappingURL=scopeBuilder.js.map
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"scopeBuilder.js","sourceRoot":"","sources":["../../src/jca/scopeBuilder.ts"],"names":[],"mappings":"AAAA;;;GAGG;AACH,OAAO,EACL,kBAAkB,EAClB,YAAY,EACZ,0BAA0B,EAC1B,UAAU,GACX,MAAM,sBAAsB,CAAC;
|
|
1
|
+
{"version":3,"file":"scopeBuilder.js","sourceRoot":"","sources":["../../src/jca/scopeBuilder.ts"],"names":[],"mappings":"AAAA;;;GAGG;AACH,OAAO,EACL,kBAAkB,EAClB,YAAY,EACZ,0BAA0B,EAC1B,UAAU,GACX,MAAM,sBAAsB,CAAC;AAsB9B,MAAM,UAAU,UAAU,CAAC,KAAwB;IACjD,MAAM,QAAQ,GAAG,kBAAkB,CAAC,KAAK,CAAC,UAAU,CAAC,CAAC;IAEtD,MAAM,gBAAgB,GAAG,KAAK,CAAC,aAAa,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE;QACrD,MAAM,CAAC,GAAG,UAAU,CAAC,CAAC,CAAC,CAAC;QACxB,MAAM,WAAW,GAAG,CAAC,CAAC,WAAW,CAC/B,QAAQ,EACR,KAAK,CAAC,UAAU,EAChB,KAAK,CAAC,eAAe,CACtB,CAAC;QACF,OAAO;YACL,YAAY,EAAE,CAAC;YACf,QAAQ,EAAE,CAAC,CAAC,QAAQ;YACpB,WAAW;YACX,oBAAoB,EAAE,CAAC,CAAC,oBAAoB,CAAC,QAAQ,CAAC;YACtD,kBAAkB,EAAE,0BAA0B,CAAC,QAAQ,CAAC;SACzD,CAAC;IACJ,CAAC,CAAC,CAAC;IAEH,MAAM,iBAAiB,GAAG,IAAI,GAAG,EAAU,CAAC;IAC5C,KAAK,MAAM,CAAC,IAAI,gBAAgB,EAAE,CAAC;QACjC,KAAK,MAAM,GAAG,IAAI,CAAC,CAAC,WAAW;YAAE,iBAAiB,CAAC,GAAG,CAAC,GAAG,CAAC,QAAQ,CAAC,CAAC;IACvE,CAAC;IACD,MAAM,yBAAyB,GAAG,iBAAiB,CAAC,IAAI,CAAC;IACzD,MAAM,qBAAqB,GACzB,KAAK,CAAC,aAAa,CAAC,MAAM,GAAG,CAAC,IAAI,yBAAyB,IAAI,CAAC,CAAC;IAEnE,MAAM,KAAK,GAAG,UAAU,CAAC,KAAK,EAAE,gBAAgB,CAAC,CAAC;IAElD,MAAM,SAAS,GAAG,cAAc,CAAC,KAAK,EAAE,QAAQ,EAAE,yBAAyB,CAAC,CAAC;IAE7E,OAAO;QACL,IAAI,EAAE,KAAK,CAAC,IAAI;QAChB,UAAU,EAAE,KAAK,CAAC,UAAU;QAC5B,mBAAmB,EAAE,QAAQ;QAC7B,YAAY,EAAE,YAAY;QAC1B,KAAK;QACL,gBAAgB;QAChB,qBAAqB;QACrB,yBAAyB;QACzB,SAAS;KACV,CAAC;AACJ,CAAC;AAED,SAAS,UAAU,CACjB,KAAwB,EACxB,gBAAgD;IAEhD,MAAM,IAAI,GAAG,IAAI,GAAG,EAAU,CAAC;IAC/B,MAAM,KAAK,GAAwB,EAAE,CAAC;IACtC,IAAI,OAAO,GAAG,CAAC,CAAC;IAChB,MAAM,cAAc,GAAG,KAAK,CAAC,gBAAgB;QAC3C,CAAC,CAAC,GAAG,KAAK,CAAC,UAAU,gBAAgB,KAAK,CAAC,gBAAgB,EAAE;QAC7D,CAAC,CAAC,KAAK,CAAC,UAAU,CAAC;IACrB,KAAK,MAAM,OAAO,IAAI,gBAAgB,EAAE,CAAC;QACvC,KAAK,MAAM,GAAG,IAAI,OAAO,CAAC,WAAW,EAAE,CAAC;YACtC,MAAM,GAAG,GAAG,GAAG,GAAG,CAAC,QAAQ,KAAK,OAAO,CAAC,kBAAkB,CAAC,IAAI,CAAC,GAAG,CAAC,EAAE,CAAC;YACvE,IAAI,IAAI,CAAC,GAAG,CAAC,GAAG,CAAC;gBAAE,SAAS;YAC5B,IAAI,CAAC,GAAG,CAAC,GAAG,CAAC,CAAC;YACd,KAAK,CAAC,IAAI,CAAC;gBACT,EAAE,EAAE,QAAQ,OAAO,EAAE;gBACrB,UAAU,EAAE,cAAc;gBAC1B,UAAU,EAAE,GAAG,CAAC,QAAQ;gBACxB,QAAQ,EAAE,OAAO,CAAC,kBAAkB,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,QAAQ,EAAE,CAAC;aAC9D,CAAC,CAAC;YACH,OAAO,IAAI,CAAC,CAAC;QACf,CAAC;IACH,CAAC;IACD,IAAI,KAAK,CAAC,MAAM,KAAK,CAAC,EAAE,CAAC;QACvB,KAAK,CAAC,IAAI,CAAC;YACT,EAAE,EAAE,QAAQ;YACZ,UAAU,EAAE,cAAc;YAC1B,UAAU,EAAE,kBAAkB;YAC9B,QAAQ,EAAE,CAAC,wBAAwB,EAAE,OAAO,EAAE,IAAI,CAAC;SACpD,CAAC,CAAC;IACL,CAAC;IACD,OAAO,KAAK,CAAC;AACf,CAAC;AAED,SAAS,cAAc,CACrB,KAAwB,EACxB,QAA+C,EAC/C,QAAgB;IAEhB,MAAM,KAAK,GAAa,EAAE,CAAC;IAC3B,KAAK,CAAC,IAAI,CACR,iBAAiB,KAAK,CAAC,IAAI,OAAO,KAAK,CAAC,UAAU,KAAK,QAAQ,qBAAqB,KAAK,CAAC,aAAa,CAAC,MAAM,mBAAmB,CAClI,CAAC;IACF,IAAI,KAAK,CAAC,kBAAkB,KAAK,mBAAmB,EAAE,CAAC;QACrD,KAAK,CAAC,IAAI,CACR,oJAAoJ,CACrJ,CAAC;IACJ,CAAC;IACD,IAAI,QAAQ,IAAI,CAAC,EAAE,CAAC;QAClB,KAAK,CAAC,IAAI,CACR,0BAA0B,QAAQ,qHAAqH,CACxJ,CAAC;IACJ,CAAC;IACD,OAAO,KAAK,CAAC,IAAI,CAAC,GAAG,CAAC,CAAC;AACzB,CAAC"}
|
package/dist/jca/types.d.ts
CHANGED
|
@@ -10,9 +10,9 @@ export interface ComparatorEntry {
|
|
|
10
10
|
export interface CountryProfile {
|
|
11
11
|
jurisdiction: Jurisdiction;
|
|
12
12
|
hta_body: string;
|
|
13
|
-
|
|
14
|
-
|
|
15
|
-
|
|
13
|
+
/** Pure function — given a drug-class and indication category, returns the comparator universe for this country.
|
|
14
|
+
* Outcome instruments + priority order live on each ComparatorEntry / are derived from the indication category;
|
|
15
|
+
* intentionally NOT cached on the country profile to avoid a dead-field trap. */
|
|
16
16
|
comparators: (indication_category: IndicationCategory, drug_class: DrugClass, line: LineOfTherapy) => ComparatorEntry[];
|
|
17
17
|
population_subgroups: (indication_category: IndicationCategory) => string[];
|
|
18
18
|
}
|
|
@@ -20,6 +20,7 @@ export type IndicationCategory = "oncology_nsclc" | "oncology_other" | "ibd_uc"
|
|
|
20
20
|
export interface PicoMatrix {
|
|
21
21
|
drug: string;
|
|
22
22
|
indication: string;
|
|
23
|
+
indication_category: IndicationCategory;
|
|
23
24
|
jca_revision: "2026-05";
|
|
24
25
|
picos: Array<{
|
|
25
26
|
id: string;
|
package/dist/jca/types.d.ts.map
CHANGED
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"types.d.ts","sourceRoot":"","sources":["../../src/jca/types.ts"],"names":[],"mappings":"AAAA,MAAM,MAAM,YAAY,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,UAAU,CAAC;AAEhF,MAAM,MAAM,SAAS,GACjB,qBAAqB,GACrB,gBAAgB,GAChB,WAAW,GACX,WAAW,GACX,aAAa,GACb,YAAY,GACZ,SAAS,GACT,qBAAqB,GACrB,OAAO,CAAC;AAEZ,MAAM,MAAM,aAAa,GACrB,YAAY,GACZ,aAAa,GACb,iBAAiB,GACjB,KAAK,CAAC;AAEV,MAAM,MAAM,eAAe,
|
|
1
|
+
{"version":3,"file":"types.d.ts","sourceRoot":"","sources":["../../src/jca/types.ts"],"names":[],"mappings":"AAAA,MAAM,MAAM,YAAY,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,UAAU,CAAC;AAEhF,MAAM,MAAM,SAAS,GACjB,qBAAqB,GACrB,gBAAgB,GAChB,WAAW,GACX,WAAW,GACX,aAAa,GACb,YAAY,GACZ,SAAS,GACT,qBAAqB,GACrB,OAAO,CAAC;AAEZ,MAAM,MAAM,aAAa,GACrB,YAAY,GACZ,aAAa,GACb,iBAAiB,GACjB,KAAK,CAAC;AAEV,MAAM,MAAM,eAAe,GACvB,IAAI,GACJ,KAAK,GACL,OAAO,GACP,IAAI,GACJ,WAAW,GACX,OAAO,CAAC;AAEZ,MAAM,WAAW,eAAe;IAC9B,QAAQ,EAAE,MAAM,CAAC;IACjB,SAAS,EAAE,MAAM,CAAC;IAClB,8BAA8B,EAAE,MAAM,EAAE,CAAC;CAC1C;AAED,MAAM,WAAW,cAAc;IAC7B,YAAY,EAAE,YAAY,CAAC;IAC3B,QAAQ,EAAE,MAAM,CAAC;IACjB;;qFAEiF;IACjF,WAAW,EAAE,CACX,mBAAmB,EAAE,kBAAkB,EACvC,UAAU,EAAE,SAAS,EACrB,IAAI,EAAE,aAAa,KAChB,eAAe,EAAE,CAAC;IACvB,oBAAoB,EAAE,CAAC,mBAAmB,EAAE,kBAAkB,KAAK,MAAM,EAAE,CAAC;CAC7E;AAED,MAAM,MAAM,kBAAkB,GAC1B,gBAAgB,GAChB,gBAAgB,GAChB,QAAQ,GACR,QAAQ,GACR,aAAa,GACb,SAAS,GACT,gBAAgB,GAChB,cAAc,GACd,WAAW,GACX,cAAc,GACd,oBAAoB,GACpB,OAAO,CAAC;AAEZ,MAAM,WAAW,UAAU;IACzB,IAAI,EAAE,MAAM,CAAC;IACb,UAAU,EAAE,MAAM,CAAC;IACnB,mBAAmB,EAAE,kBAAkB,CAAC;IACxC,YAAY,EAAE,SAAS,CAAC;IACxB,KAAK,EAAE,KAAK,CAAC;QACX,EAAE,EAAE,MAAM,CAAC;QACX,UAAU,EAAE,MAAM,CAAC;QACnB,UAAU,EAAE,MAAM,CAAC;QACnB,QAAQ,EAAE,MAAM,EAAE,CAAC;KACpB,CAAC,CAAC;IACH,gBAAgB,EAAE,KAAK,CAAC;QACtB,YAAY,EAAE,YAAY,CAAC;QAC3B,QAAQ,EAAE,MAAM,CAAC;QACjB,WAAW,EAAE,eAAe,EAAE,CAAC;QAC/B,oBAAoB,EAAE,MAAM,EAAE,CAAC;QAC/B,kBAAkB,EAAE,eAAe,EAAE,CAAC;KACvC,CAAC,CAAC;IACH,qBAAqB,EAAE,OAAO,CAAC;IAC/B,yBAAyB,EAAE,MAAM,CAAC;IAClC,SAAS,EAAE,MAAM,CAAC;CACnB"}
|
|
@@ -2,7 +2,7 @@ import type { ToolResult } from "../providers/types.js";
|
|
|
2
2
|
export declare function handleJcaPicoScope(rawInput: unknown): Promise<ToolResult>;
|
|
3
3
|
export declare const jcaPicoScopeToolSchema: {
|
|
4
4
|
readonly name: "jca.pico_scope";
|
|
5
|
-
readonly description: "Produce the canonical EU Joint Clinical Assessment (JCA) PICO matrix for a drug-indication pair. Returns a consolidated PICO list (per JCA process under Reg. 2021/2282) plus country-specific comparator universes, outcome instrument preferences, population subgroup focus, and a heterogeneity warning
|
|
5
|
+
readonly description: "Produce the canonical EU Joint Clinical Assessment (JCA) PICO matrix for a drug-indication pair. Returns a consolidated PICO list (per JCA process under Reg. 2021/2282) plus country-specific comparator universes, outcome instrument preferences, population subgroup focus, and a heterogeneity warning. Pipe `pico_matrix.picos` directly into `hta_dossier({hta_body:\"jca\", picos: ...})`. v1 covers DE/FR/IT/ES/NL + UK (post-Brexit context). Heterogeneity warning fires at ≥3 distinct comparator molecules across ≥2 jurisdictions — a tool-level assumption, not a published EUnetHTA threshold; treat the warning as a prompt to run evidence_network + itc_feasibility, not as a definitive diagnosis. NSCLC EGFR-mutant comparator detail is currently modeled only for line_of_therapy=\"second_line\"; other lines use a generic chemotherapy anchor with a warning.";
|
|
6
6
|
readonly annotations: {
|
|
7
7
|
readonly title: "JCA PICO Scope Analyzer";
|
|
8
8
|
readonly readOnlyHint: true;
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"jcaPicoScope.d.ts","sourceRoot":"","sources":["../../src/tools/jcaPicoScope.ts"],"names":[],"mappings":"AAoBA,OAAO,KAAK,EAAE,UAAU,EAAE,MAAM,uBAAuB,CAAC;
|
|
1
|
+
{"version":3,"file":"jcaPicoScope.d.ts","sourceRoot":"","sources":["../../src/tools/jcaPicoScope.ts"],"names":[],"mappings":"AAoBA,OAAO,KAAK,EAAE,UAAU,EAAE,MAAM,uBAAuB,CAAC;AAwCxD,wBAAsB,kBAAkB,CACtC,QAAQ,EAAE,OAAO,GAChB,OAAO,CAAC,UAAU,CAAC,CA0NrB;AAED,eAAO,MAAM,sBAAsB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;CAqCzB,CAAC"}
|
|
@@ -24,15 +24,7 @@ const DRUG_CLASSES = [
|
|
|
24
24
|
"other",
|
|
25
25
|
];
|
|
26
26
|
const LINES = ["first_line", "second_line", "third_line_plus", "any"];
|
|
27
|
-
const JURISDICTIONS = [
|
|
28
|
-
"de",
|
|
29
|
-
"fr",
|
|
30
|
-
"it",
|
|
31
|
-
"es",
|
|
32
|
-
"nl",
|
|
33
|
-
"uk",
|
|
34
|
-
"eu_other",
|
|
35
|
-
];
|
|
27
|
+
const JURISDICTIONS = ["de", "fr", "it", "es", "nl", "uk", "eu_other"];
|
|
36
28
|
const REG_CONTEXTS = [
|
|
37
29
|
"pre_authorisation",
|
|
38
30
|
"post_authorisation",
|
|
@@ -91,6 +83,10 @@ export async function handleJcaPicoScope(rawInput) {
|
|
|
91
83
|
if (input.regulatory_context === "pre_authorisation") {
|
|
92
84
|
audit = addWarning(audit, "Pre-authorisation context — output is anticipatory only, not a JCA-finalised PICO list.");
|
|
93
85
|
}
|
|
86
|
+
if (matrix.indication_category === "oncology_nsclc" &&
|
|
87
|
+
input.line_of_therapy !== "second_line") {
|
|
88
|
+
audit = addWarning(audit, `NSCLC comparator detail (chemo doublet + IO + alternative TKI) is currently modeled only for line_of_therapy="second_line"; you passed "${input.line_of_therapy}", so the per-country EGFR-mutant detail was skipped and a generic chemotherapy anchor was used instead. Re-run with line_of_therapy="second_line" for the well-modeled case.`);
|
|
89
|
+
}
|
|
94
90
|
const lines = [];
|
|
95
91
|
lines.push(`# JCA PICO Scope — ${input.drug} (${input.indication})`);
|
|
96
92
|
lines.push("");
|
|
@@ -104,6 +100,11 @@ export async function handleJcaPicoScope(rawInput) {
|
|
|
104
100
|
lines.push(`> ⚠️ **Comparator heterogeneity warning.** ${matrix.distinct_comparator_count} distinct comparator molecules across ${input.jurisdictions.length} jurisdictions. Run \`evidence_network\` + \`itc_feasibility\` before any quantitative estimation.`);
|
|
105
101
|
lines.push("");
|
|
106
102
|
}
|
|
103
|
+
if (matrix.indication_category === "oncology_nsclc" &&
|
|
104
|
+
input.line_of_therapy !== "second_line") {
|
|
105
|
+
lines.push(`> ⚠️ **NSCLC line-of-therapy gap.** Detailed EGFR-mutant comparator detail is modeled only for \`line_of_therapy: "second_line"\`. You passed \`"${input.line_of_therapy}"\`, so a generic chemotherapy anchor was used per country. Re-run with \`line_of_therapy: "second_line"\` for the well-modeled case (chemo doublet + IO + alternative TKI by country).`);
|
|
106
|
+
lines.push("");
|
|
107
|
+
}
|
|
107
108
|
lines.push("## Rationale");
|
|
108
109
|
lines.push(matrix.rationale);
|
|
109
110
|
lines.push("");
|
|
@@ -114,10 +115,18 @@ export async function handleJcaPicoScope(rawInput) {
|
|
|
114
115
|
lines.push(`| ${p.id} | ${p.population} | ${p.comparator} | ${p.outcomes.join(", ")} |`);
|
|
115
116
|
}
|
|
116
117
|
lines.push("");
|
|
117
|
-
lines.push(
|
|
118
|
+
lines.push('*Pipe `pico_matrix.picos` directly into `hta_dossier({hta_body:"jca", picos: ...})` to expand into a multi-PICO dossier.*');
|
|
118
119
|
lines.push("");
|
|
119
120
|
for (const c of matrix.country_specific) {
|
|
120
|
-
const flag = {
|
|
121
|
+
const flag = {
|
|
122
|
+
de: "🇩🇪 Germany",
|
|
123
|
+
fr: "🇫🇷 France",
|
|
124
|
+
it: "🇮🇹 Italy",
|
|
125
|
+
es: "🇪🇸 Spain",
|
|
126
|
+
nl: "🇳🇱 Netherlands",
|
|
127
|
+
uk: "🇬🇧 United Kingdom",
|
|
128
|
+
eu_other: "🇪🇺 Other EU member states",
|
|
129
|
+
}[c.jurisdiction] ?? c.jurisdiction;
|
|
121
130
|
lines.push(`## ${flag} — ${c.hta_body}`);
|
|
122
131
|
if (c.jurisdiction === "uk") {
|
|
123
132
|
lines.push("*Post-Brexit, NICE alignment context only — UK is outside the JCA process but most submissions still target NICE in parallel.*");
|
|
@@ -141,8 +150,12 @@ export async function handleJcaPicoScope(rawInput) {
|
|
|
141
150
|
lines.push(`**Outcome priority order:** ${c.outcome_priorities.join(" → ")}`);
|
|
142
151
|
lines.push("");
|
|
143
152
|
}
|
|
144
|
-
// Surrogate-endpoint note for oncology indications
|
|
145
|
-
|
|
153
|
+
// Surrogate-endpoint note for oncology indications. Use the category
|
|
154
|
+
// directly rather than guessing from outcome_priorities[0]==="OS" — the
|
|
155
|
+
// proxy was correct only by coincidence and would misfire if any future
|
|
156
|
+
// non-oncology category gets OS-first priorities.
|
|
157
|
+
const isOncology = matrix.indication_category === "oncology_nsclc" ||
|
|
158
|
+
matrix.indication_category === "oncology_other";
|
|
146
159
|
if (isOncology) {
|
|
147
160
|
lines.push("## Surrogate Endpoints");
|
|
148
161
|
lines.push("JCA prefers patient-relevant outcomes per Annex II of Implementing Regulation 2024/1381. **Surrogate endpoints (PFS, ORR, biomarker response) are accepted as secondary outcomes only and may face JCA scrutiny.** Plan an OS analysis even when PFS is the trial primary endpoint, and pre-specify any OS-from-PFS surrogacy assumptions in the dossier.");
|
|
@@ -172,7 +185,7 @@ export async function handleJcaPicoScope(rawInput) {
|
|
|
172
185
|
}
|
|
173
186
|
export const jcaPicoScopeToolSchema = {
|
|
174
187
|
name: "jca.pico_scope",
|
|
175
|
-
description:
|
|
188
|
+
description: 'Produce the canonical EU Joint Clinical Assessment (JCA) PICO matrix for a drug-indication pair. Returns a consolidated PICO list (per JCA process under Reg. 2021/2282) plus country-specific comparator universes, outcome instrument preferences, population subgroup focus, and a heterogeneity warning. Pipe `pico_matrix.picos` directly into `hta_dossier({hta_body:"jca", picos: ...})`. v1 covers DE/FR/IT/ES/NL + UK (post-Brexit context). Heterogeneity warning fires at ≥3 distinct comparator molecules across ≥2 jurisdictions — a tool-level assumption, not a published EUnetHTA threshold; treat the warning as a prompt to run evidence_network + itc_feasibility, not as a definitive diagnosis. NSCLC EGFR-mutant comparator detail is currently modeled only for line_of_therapy="second_line"; other lines use a generic chemotherapy anchor with a warning.',
|
|
176
189
|
annotations: {
|
|
177
190
|
title: "JCA PICO Scope Analyzer",
|
|
178
191
|
readOnlyHint: true,
|
|
@@ -1 +1 @@
|
|
|
1
|
-
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