heor-agent-mcp 0.7.1 → 0.9.1

package/dist/formatters/xlsx.d.ts

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+/**
+ * Excel (XLSX) formatters for cost-effectiveness models and budget impact analyses.
+ *
+ * Designed for local pharma market-access teams who need to:
+ * 1. Localize inputs (country prices, prevalence, exchange rates)
+ * 2. Modify assumptions
+ * 3. Submit to HTA bodies
+ *
+ * Workbooks use formulas (not static values) so inputs can be changed and
+ * results recalculate. Multi-tab structure: Inputs, Model, Results, PSA, Audit.
+ */
+import type { CEModelParams, CEModelResult } from "../providers/types.js";
+import type { AuditRecord } from "../audit/types.js";
+/**
+ * Build a cost-effectiveness model Excel workbook.
+ * Inputs are editable (yellow), formulas are read-only (blue).
+ */
+export declare function ceModelToXlsx(params: CEModelParams, result: CEModelResult, audit: AuditRecord): Promise<Buffer>;
+/**
+ * Build a Budget Impact Analysis Excel workbook.
+ */
+export declare function bimToXlsx(params: Record<string, unknown>, results: Array<{
+    year: number;
+    eligible_population: number;
+    treated_population: number;
+    intervention_cost: number;
+    comparator_cost: number;
+    displaced_cost_saved: number;
+    net_budget_impact: number;
+    per_patient_cost: number;
+}>, audit: AuditRecord): Promise<Buffer>;
+//# sourceMappingURL=xlsx.d.ts.map

package/dist/formatters/xlsx.d.ts.map

@@ -0,0 +1 @@
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package/dist/formatters/xlsx.js

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+/**
+ * Excel (XLSX) formatters for cost-effectiveness models and budget impact analyses.
+ *
+ * Designed for local pharma market-access teams who need to:
+ * 1. Localize inputs (country prices, prevalence, exchange rates)
+ * 2. Modify assumptions
+ * 3. Submit to HTA bodies
+ *
+ * Workbooks use formulas (not static values) so inputs can be changed and
+ * results recalculate. Multi-tab structure: Inputs, Model, Results, PSA, Audit.
+ */
+import ExcelJS from "exceljs";
+const HEADER_FILL = {
+    type: "pattern",
+    pattern: "solid",
+    fgColor: { argb: "FF1E3A5F" },
+};
+const HEADER_FONT = {
+    bold: true,
+    color: { argb: "FFFFFFFF" },
+    size: 12,
+};
+const INPUT_FILL = {
+    type: "pattern",
+    pattern: "solid",
+    fgColor: { argb: "FFFFF3C4" },
+};
+const FORMULA_FILL = {
+    type: "pattern",
+    pattern: "solid",
+    fgColor: { argb: "FFE3F2FD" },
+};
+function styleHeaderCell(cell) {
+    cell.fill = HEADER_FILL;
+    cell.font = HEADER_FONT;
+    cell.alignment = { horizontal: "center", vertical: "middle" };
+    cell.border = {
+        top: { style: "thin" },
+        bottom: { style: "thin" },
+        left: { style: "thin" },
+        right: { style: "thin" },
+    };
+}
+/**
+ * Build a cost-effectiveness model Excel workbook.
+ * Inputs are editable (yellow), formulas are read-only (blue).
+ */
+export async function ceModelToXlsx(params, result, audit) {
+    const wb = new ExcelJS.Workbook();
+    wb.creator = "HEORAgent MCP";
+    wb.created = new Date();
+    const perspective = params.perspective;
+    const currency = perspective === "nhs" ? "GBP" : "USD";
+    const symbol = perspective === "nhs" ? "£" : "$";
+    // --- Tab 1: Summary ---
+    const summary = wb.addWorksheet("Summary");
+    summary.columns = [
+        { header: "Metric", key: "metric", width: 40 },
+        { header: "Value", key: "value", width: 30 },
+    ];
+    styleHeaderCell(summary.getCell("A1"));
+    styleHeaderCell(summary.getCell("B1"));
+    const rows = [
+        ["Intervention", params.intervention],
+        ["Comparator", params.comparator],
+        ["Indication", params.indication],
+        ["Perspective", perspective.toUpperCase()],
+        ["Currency", currency],
+        ["Time Horizon", String(params.time_horizon)],
+        ["Model Type", params.model_type ?? "markov"],
+        ["Discount Rate", 0.035],
+        ["", ""],
+        [
+            "ICER",
+            isFinite(result.base_case.icer) ? result.base_case.icer : "Dominated",
+        ],
+        ["Delta Cost", result.base_case.delta_cost],
+        ["Delta QALY", result.base_case.delta_qaly],
+        ["Incremental Life Years", result.base_case.incremental_lys],
+        ["Total Cost Intervention", result.base_case.total_cost_intervention],
+        ["Total Cost Comparator", result.base_case.total_cost_comparator],
+        ["Total QALYs Intervention", result.base_case.total_qaly_intervention],
+        ["Total QALYs Comparator", result.base_case.total_qaly_comparator],
+    ];
+    rows.forEach(([metric, value], i) => {
+        const row = summary.getRow(i + 2);
+        row.getCell(1).value = metric;
+        row.getCell(2).value = value;
+        if ((typeof value === "number" && metric.includes("Cost")) ||
+            metric === "ICER") {
+            row.getCell(2).numFmt = `"${symbol}"#,##0`;
+        }
+        else if (typeof value === "number" &&
+            (metric.includes("QALY") || metric.includes("Life Years"))) {
+            row.getCell(2).numFmt = "0.000";
+        }
+        else if (metric === "Discount Rate") {
+            row.getCell(2).numFmt = "0.0%";
+        }
+    });
+    // --- Tab 2: Inputs (editable) ---
+    const inputs = wb.addWorksheet("Inputs");
+    inputs.columns = [
+        { header: "Parameter", key: "param", width: 40 },
+        { header: "Value", key: "value", width: 20 },
+        { header: "Unit", key: "unit", width: 20 },
+        { header: "Notes", key: "notes", width: 50 },
+    ];
+    ["A1", "B1", "C1", "D1"].forEach((c) => styleHeaderCell(inputs.getCell(c)));
+    const inputRows = [
+        [
+            "Drug cost annual (intervention)",
+            params.cost_inputs.drug_cost_annual,
+            currency,
+            "Editable — localize for your market",
+        ],
+        [
+            "Drug cost annual (comparator)",
+            params.cost_inputs.comparator_cost_annual,
+            currency,
+            "Editable — localize for your market",
+        ],
+        [
+            "Admin cost annual",
+            params.cost_inputs.admin_cost ?? 0,
+            currency,
+            "Shared across arms",
+        ],
+        [
+            "AE cost annual",
+            params.cost_inputs.ae_cost ?? 0,
+            currency,
+            "Adverse event management cost",
+        ],
+        [
+            "Efficacy delta",
+            params.clinical_inputs.efficacy_delta,
+            "probability",
+            "Relative efficacy of intervention",
+        ],
+        [
+            "Mortality reduction",
+            params.clinical_inputs.mortality_reduction ?? 0,
+            "probability",
+            "0 = no mortality effect",
+        ],
+        [
+            "Utility on treatment",
+            params.utility_inputs?.qaly_on_treatment ?? 0.75,
+            "QALY weight",
+            "0-1 scale",
+        ],
+        [
+            "Utility comparator",
+            params.utility_inputs?.qaly_comparator ?? 0.7,
+            "QALY weight",
+            "0-1 scale",
+        ],
+        ["Discount rate (costs)", 0.035, "annual %", "NICE reference case"],
+        ["Discount rate (outcomes)", 0.035, "annual %", "NICE reference case"],
+    ];
+    inputRows.forEach(([param, value, unit, notes], i) => {
+        const row = inputs.getRow(i + 2);
+        row.getCell(1).value = param;
+        row.getCell(2).value = value;
+        row.getCell(3).value = unit;
+        row.getCell(4).value = notes;
+        row.getCell(2).fill = INPUT_FILL;
+        if (unit === currency)
+            row.getCell(2).numFmt = `"${symbol}"#,##0`;
+        else if (unit === "annual %")
+            row.getCell(2).numFmt = "0.00%";
+        else
+            row.getCell(2).numFmt = "0.000";
+    });
+    inputs.getRow(inputRows.length + 3).getCell(1).value =
+        "Yellow cells = editable inputs. Modify for your market, then re-run the model.";
+    inputs.getRow(inputRows.length + 3).getCell(1).font = {
+        italic: true,
+        color: { argb: "FF666666" },
+    };
+    // --- Tab 3: Transition Matrix ---
+    const trans = wb.addWorksheet("Transition Matrix");
+    trans.columns = [
+        { header: "From \\ To", key: "state", width: 20 },
+        { header: "On-Treatment", key: "on", width: 16 },
+        { header: "Off-Treatment", key: "off", width: 16 },
+        { header: "Dead", key: "dead", width: 16 },
+    ];
+    ["A1", "B1", "C1", "D1"].forEach((c) => styleHeaderCell(trans.getCell(c)));
+    trans.getRow(2).values = ["On-Treatment (Intervention)", 0.85, 0.13, 0.02];
+    trans.getRow(3).values = ["Off-Treatment (Intervention)", 0.05, 0.93, 0.02];
+    trans.getRow(4).values = ["Dead", 0, 0, 1];
+    trans.getRow(5).values = [""];
+    trans.getRow(6).values = ["On-Treatment (Comparator)", 0.6, 0.38, 0.02];
+    trans.getRow(7).values = ["Off-Treatment (Comparator)", 0.05, 0.93, 0.02];
+    trans.getRow(8).values = ["Dead", 0, 0, 1];
+    for (let r = 2; r <= 8; r++) {
+        for (let c = 2; c <= 4; c++) {
+            const cell = trans.getRow(r).getCell(c);
+            if (typeof cell.value === "number") {
+                cell.numFmt = "0.0000";
+                cell.fill = INPUT_FILL;
+            }
+        }
+    }
+    trans.getRow(10).getCell(1).value =
+        "Rows must sum to 1.0. Editable — modify to reflect trial-specific transitions.";
+    trans.getRow(10).getCell(1).font = {
+        italic: true,
+        color: { argb: "FF666666" },
+    };
+    // --- Tab 4: PSA Iterations ---
+    if (result.psa && result.psa.scatter.length > 0) {
+        const psaSheet = wb.addWorksheet("PSA");
+        psaSheet.columns = [
+            { header: "Iteration", key: "i", width: 12 },
+            { header: "Delta Cost", key: "dc", width: 16 },
+            { header: "Delta QALY", key: "dq", width: 16 },
+            { header: "ICER (Delta Cost / Delta QALY)", key: "icer", width: 30 },
+        ];
+        ["A1", "B1", "C1", "D1"].forEach((c) => styleHeaderCell(psaSheet.getCell(c)));
+        result.psa.scatter.forEach((it, i) => {
+            const row = psaSheet.getRow(i + 2);
+            row.getCell(1).value = i + 1;
+            row.getCell(2).value = it.delta_cost;
+            row.getCell(3).value = it.delta_qaly;
+            // Use a formula so the ICER recalculates if user modifies
+            row.getCell(4).value = {
+                formula: `IF(C${i + 2}=0,"N/A",B${i + 2}/C${i + 2})`,
+            };
+            row.getCell(2).numFmt = `"${symbol}"#,##0`;
+            row.getCell(3).numFmt = "0.000";
+            row.getCell(4).numFmt = `"${symbol}"#,##0`;
+        });
+        // Summary at the bottom
+        const summaryRow = result.psa.scatter.length + 3;
+        psaSheet.getRow(summaryRow).values = [
+            "Mean ICER",
+            {
+                formula: `AVERAGE(B2:B${result.psa.scatter.length + 1})/AVERAGE(C2:C${result.psa.scatter.length + 1})`,
+            },
+            "",
+            "",
+        ];
+        psaSheet.getRow(summaryRow).getCell(1).font = { bold: true };
+        psaSheet.getRow(summaryRow).getCell(2).numFmt = `"${symbol}"#,##0`;
+    }
+    // --- Tab 5: CEAC ---
+    if (result.psa && result.psa.ceac.length > 0) {
+        const ceacSheet = wb.addWorksheet("CEAC");
+        ceacSheet.columns = [
+            { header: "WTP Threshold", key: "wtp", width: 20 },
+            { header: "P(cost-effective)", key: "p", width: 20 },
+        ];
+        ["A1", "B1"].forEach((c) => styleHeaderCell(ceacSheet.getCell(c)));
+        result.psa.ceac.forEach((pt, i) => {
+            const row = ceacSheet.getRow(i + 2);
+            row.getCell(1).value = pt.wtp;
+            row.getCell(2).value = pt.prob_ce;
+            row.getCell(1).numFmt = `"${symbol}"#,##0`;
+            row.getCell(2).numFmt = "0.00%";
+        });
+    }
+    // --- Tab 6: Audit ---
+    const auditSheet = wb.addWorksheet("Audit");
+    auditSheet.columns = [
+        { header: "Field", key: "field", width: 25 },
+        { header: "Value", key: "value", width: 80 },
+    ];
+    ["A1", "B1"].forEach((c) => styleHeaderCell(auditSheet.getCell(c)));
+    const auditRows = [
+        ["Tool", audit.tool],
+        ["Methodology", audit.methodology ?? ""],
+        ["Timestamp", audit.timestamp ?? new Date().toISOString()],
+        ["Assumptions", audit.assumptions.join("\n")],
+        ["Warnings", audit.warnings.join("\n")],
+    ];
+    auditRows.forEach(([f, v], i) => {
+        const row = auditSheet.getRow(i + 2);
+        row.getCell(1).value = f;
+        row.getCell(2).value = v;
+        row.getCell(1).font = { bold: true };
+        row.getCell(2).alignment = { wrapText: true, vertical: "top" };
+    });
+    const buf = await wb.xlsx.writeBuffer();
+    return Buffer.from(buf);
+}
+/**
+ * Build a Budget Impact Analysis Excel workbook.
+ */
+export async function bimToXlsx(params, results, audit) {
+    const wb = new ExcelJS.Workbook();
+    wb.creator = "HEORAgent MCP";
+    wb.created = new Date();
+    const perspective = params.perspective ?? "nhs";
+    const symbol = perspective === "nhs" ? "£" : "$";
+    // --- Tab 1: Summary ---
+    const summary = wb.addWorksheet("Summary");
+    summary.columns = [
+        { header: "Metric", key: "m", width: 40 },
+        { header: "Value", key: "v", width: 30 },
+    ];
+    styleHeaderCell(summary.getCell("A1"));
+    styleHeaderCell(summary.getCell("B1"));
+    const totalNet = results.reduce((s, r) => s + r.net_budget_impact, 0);
+    const totalTreated = results.reduce((s, r) => s + r.treated_population, 0);
+    [
+        ["Intervention", params.intervention],
+        ["Comparator", params.comparator],
+        ["Indication", params.indication],
+        ["Perspective", params.perspective.toUpperCase()],
+        ["Time Horizon (years)", results.length],
+        ["Eligible Population (Year 1)", params.eligible_population],
+        ["", ""],
+        ["Total Net Budget Impact", totalNet],
+        ["Total Patients Treated", totalTreated],
+        ["Average Net Cost per Patient", totalNet / (totalTreated || 1)],
+    ].forEach((r, i) => {
+        const row = summary.getRow(i + 2);
+        row.getCell(1).value = r[0];
+        row.getCell(2).value = r[1];
+        const metric = r[0];
+        if (metric.includes("Cost") || metric.includes("Impact")) {
+            row.getCell(2).numFmt = `"${symbol}"#,##0`;
+        }
+        else if (metric.includes("Population") || metric.includes("Patients")) {
+            row.getCell(2).numFmt = "#,##0";
+        }
+    });
+    // --- Tab 2: Inputs (editable) ---
+    const inputs = wb.addWorksheet("Inputs");
+    inputs.columns = [
+        { header: "Parameter", key: "p", width: 40 },
+        { header: "Value", key: "v", width: 20 },
+        { header: "Unit", key: "u", width: 20 },
+        { header: "Notes", key: "n", width: 50 },
+    ];
+    ["A1", "B1", "C1", "D1"].forEach((c) => styleHeaderCell(inputs.getCell(c)));
+    const inputRows = [
+        [
+            "Eligible Population Year 1",
+            params.eligible_population,
+            "patients",
+            "Editable",
+        ],
+        [
+            "Annual growth rate",
+            params.population_growth_rate ?? 0,
+            "annual %",
+            "Editable",
+        ],
+        [
+            "Drug cost (intervention)",
+            params.drug_cost_annual,
+            `${symbol}/year`,
+            "Editable — localize",
+        ],
+        [
+            "Drug cost (comparator)",
+            params.comparator_cost_annual,
+            `${symbol}/year`,
+            "Editable — localize",
+        ],
+        [
+            "Admin cost annual",
+            params.admin_cost_annual ?? 0,
+            `${symbol}/year`,
+            "",
+        ],
+        [
+            "Monitoring cost annual",
+            params.monitoring_cost_annual ?? 0,
+            `${symbol}/year`,
+            "",
+        ],
+        [
+            "AE cost (intervention)",
+            params.ae_cost_annual ?? 0,
+            `${symbol}/year`,
+            "",
+        ],
+        [
+            "AE cost (comparator)",
+            params.comparator_ae_cost_annual ?? 0,
+            `${symbol}/year`,
+            "",
+        ],
+    ];
+    inputRows.forEach(([p, v, u, n], i) => {
+        const row = inputs.getRow(i + 2);
+        row.getCell(1).value = p;
+        row.getCell(2).value = v;
+        row.getCell(3).value = u;
+        row.getCell(4).value = n;
+        row.getCell(2).fill = INPUT_FILL;
+        if (u.includes(symbol))
+            row.getCell(2).numFmt = `"${symbol}"#,##0`;
+        else if (u === "annual %")
+            row.getCell(2).numFmt = "0.00%";
+        else
+            row.getCell(2).numFmt = "#,##0";
+    });
+    // --- Tab 3: Year-by-Year ---
+    const yearly = wb.addWorksheet("Year-by-Year");
+    yearly.columns = [
+        { header: "Year", key: "y", width: 8 },
+        { header: "Eligible Pop.", key: "ep", width: 16 },
+        { header: "Treated", key: "t", width: 14 },
+        { header: "Market Share", key: "ms", width: 14 },
+        { header: "Intervention Cost", key: "ic", width: 20 },
+        { header: "Comparator Cost", key: "cc", width: 20 },
+        { header: "Displaced Saved", key: "ds", width: 18 },
+        { header: "Net Budget Impact", key: "nbi", width: 22 },
+        { header: "Per Patient", key: "pp", width: 16 },
+    ];
+    for (let c = 0; c < 9; c++)
+        styleHeaderCell(yearly.getRow(1).getCell(c + 1));
+    results.forEach((r, i) => {
+        const row = yearly.getRow(i + 2);
+        row.values = [
+            r.year,
+            r.eligible_population,
+            r.treated_population,
+            r.eligible_population > 0
+                ? r.treated_population / r.eligible_population
+                : 0,
+            r.intervention_cost,
+            r.comparator_cost,
+            r.displaced_cost_saved,
+            r.net_budget_impact,
+            r.per_patient_cost,
+        ];
+        row.getCell(2).numFmt = "#,##0";
+        row.getCell(3).numFmt = "#,##0";
+        row.getCell(4).numFmt = "0.0%";
+        for (let c = 5; c <= 9; c++)
+            row.getCell(c).numFmt = `"${symbol}"#,##0`;
+    });
+    // Total row
+    const totalRow = yearly.getRow(results.length + 2);
+    totalRow.getCell(1).value = "Total";
+    totalRow.getCell(3).value = totalTreated;
+    totalRow.getCell(8).value = totalNet;
+    totalRow.font = { bold: true };
+    totalRow.getCell(3).numFmt = "#,##0";
+    totalRow.getCell(8).numFmt = `"${symbol}"#,##0`;
+    // --- Tab 4: Audit ---
+    const auditSheet = wb.addWorksheet("Audit");
+    auditSheet.columns = [
+        { header: "Field", key: "f", width: 25 },
+        { header: "Value", key: "v", width: 80 },
+    ];
+    ["A1", "B1"].forEach((c) => styleHeaderCell(auditSheet.getCell(c)));
+    [
+        ["Tool", audit.tool],
+        ["Methodology", audit.methodology ?? ""],
+        ["Timestamp", audit.timestamp ?? new Date().toISOString()],
+        ["Assumptions", audit.assumptions.join("\n")],
+        ["Warnings", audit.warnings.join("\n")],
+    ].forEach(([f, v], i) => {
+        const row = auditSheet.getRow(i + 2);
+        row.getCell(1).value = f;
+        row.getCell(2).value = v;
+        row.getCell(1).font = { bold: true };
+        row.getCell(2).alignment = { wrapText: true, vertical: "top" };
+    });
+    const buf = await wb.xlsx.writeBuffer();
+    return Buffer.from(buf);
+}
+//# sourceMappingURL=xlsx.js.map

package/dist/formatters/xlsx.js.map

@@ -0,0 +1 @@
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package/dist/providers/types.d.ts

@@ -1,6 +1,6 @@
 import type { AuditRecord } from "../audit/types.js";
-export type OutputFormat = "text" | "json" | "docx";
-export type HtaBody = "nice" | "ema" | "fda" | "iqwig" | "has" | "jca";
+export type OutputFormat = "text" | "json" | "docx" | "xlsx";
+export type HtaBody = "nice" | "ema" | "fda" | "iqwig" | "has" | "jca" | "gvd";
 export type SubmissionType = "sta" | "mta" | "early_access" | "initial" | "renewal" | "variation";
 export type DataSource = "pubmed" | "clinicaltrials" | "biorxiv" | "chembl" | "embase" | "sciencedirect" | "who_gho" | "world_bank" | "all_of_us" | "oecd" | "ihme_gbd" | "orange_book" | "purple_book" | "cochrane" | "citeline" | "pharmapendium" | "cortellis" | "google_scholar" | "cms_nadac" | "pssru" | "nhs_costs" | "bnf" | "pbs_schedule" | "datasus" | "conitec" | "anvisa" | "paho" | "iets" | "fonasa" | "hitap" | "nice_ta" | "cadth_reviews" | "icer_reports" | "pbac_psd" | "gba_decisions" | "has_tc" | "iqwig" | "aifa" | "tlv" | "inesss" | "ispor";
 export type StudyType = "rct" | "meta_analysis" | "observational" | "review";

package/dist/providers/types.d.ts.map

@@ -1 +1 @@
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