heor-agent-mcp 0.1.4 → 0.1.6
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/README.md +64 -5
- package/dist/models/psa.d.ts.map +1 -1
- package/dist/models/psa.js +17 -14
- package/dist/models/psa.js.map +1 -1
- package/dist/providers/direct/cadthReviews.js +9 -9
- package/dist/providers/direct/cadthReviews.js.map +1 -1
- package/dist/providers/direct/icerReports.d.ts.map +1 -1
- package/dist/providers/direct/icerReports.js +1 -1
- package/dist/providers/direct/icerReports.js.map +1 -1
- package/dist/providers/direct/iqwig.d.ts.map +1 -1
- package/dist/providers/direct/iqwig.js +5 -3
- package/dist/providers/direct/iqwig.js.map +1 -1
- package/dist/providers/direct/niceTa.d.ts.map +1 -1
- package/dist/providers/direct/niceTa.js +1 -1
- package/dist/providers/direct/niceTa.js.map +1 -1
- package/dist/providers/direct/pbacPsd.d.ts.map +1 -1
- package/dist/providers/direct/pbacPsd.js +1 -1
- package/dist/providers/direct/pbacPsd.js.map +1 -1
- package/dist/providers/direct/tlv.d.ts.map +1 -1
- package/dist/providers/direct/tlv.js +4 -2
- package/dist/providers/direct/tlv.js.map +1 -1
- package/dist/sources/registry.js +2 -2
- package/dist/sources/registry.js.map +1 -1
- package/dist/tools/costEffectivenessModel.js +1 -1
- package/package.json +1 -1
package/README.md
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@@ -79,7 +79,7 @@ Multi-state Markov model (default) or Partitioned Survival Analysis (oncology),
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- **OWSA** — one-way sensitivity analysis with tornado summary
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- **CEAC** — cost-effectiveness acceptability curve
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- **EVPI** — expected value of perfect information
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- **WTP assessment** — verdict against NHS (£
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- **WTP assessment** — verdict against NHS (£25–35K/QALY, updated April 2026), US payer ($100–150K), societal thresholds
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**Example call:**
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```json
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@@ -257,11 +257,57 @@ HEOR_API_KEY=...
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---
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## Web UI
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A companion chat interface is available at:
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**https://web-michael-ns-projects.vercel.app**
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- Chat with Claude Opus 4.6 + all 7 HEOR tools
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- **BYOK (Bring Your Own Key)** — paste your Anthropic API key in the settings; it stays in your browser's localStorage and is never stored on our servers
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- Markdown rendering with styled tables, tool call cards with live progress timers
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- Example prompts for common HEOR workflows
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The web UI calls the hosted MCP server on Railway for tool execution. No setup required — just add your API key and start querying.
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### Self-hosting the web UI
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```bash
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cd web
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npm install
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echo "ANTHROPIC_API_KEY=sk-ant-..." > .env.local # optional server-side fallback
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npm run dev -- -p 3456
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```
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Set `MCP_SERVER_URL` to point to your own MCP server instance (default: the public Railway deployment).
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---
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## HTTP Transport
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The server supports both **stdio** (default, for local MCP clients) and **Streamable HTTP** (for hosted deployment).
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```bash
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# Stdio mode (default — for Claude Code, Claude Desktop)
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npx heor-agent-mcp
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# HTTP mode — for hosted deployment, Smithery, web UI backend
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npx heor-agent-mcp --http # port 8787
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MCP_HTTP_PORT=3000 npx heor-agent-mcp # custom port
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```
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HTTP endpoints:
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- `POST/GET/DELETE /mcp` — MCP Streamable HTTP protocol
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- `GET /health` — health check
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- `GET /.well-known/mcp/server-card.json` — Smithery discovery
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---
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## Development
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```bash
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git clone https://github.com/neptun2000/
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cd
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git clone https://github.com/neptun2000/heor-agent-mcp
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cd heor-agent-mcp
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npm install
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npm test # 244 tests across 66 suites
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npm run build # Compile TypeScript to dist/
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@@ -316,8 +362,21 @@ MIT — see [LICENSE](./LICENSE).
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---
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## Distribution
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| Channel | How to use | Who pays |
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|---------|-----------|----------|
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| **npm** | `npx heor-agent-mcp` | User's Claude subscription |
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| **Smithery** | [smithery.ai/servers/neptun2000-70zu/heor-agent-mcp](https://smithery.ai/servers/neptun2000-70zu/heor-agent-mcp) | User's Claude subscription |
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| **Web UI** | [web-michael-ns-projects.vercel.app](https://web-michael-ns-projects.vercel.app) | User's own Anthropic API key (BYOK) |
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| **Hosted MCP** | `https://heor-agent-mcp-production.up.railway.app` | Free (tool execution only) |
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---
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## Links
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- **npm:** https://www.npmjs.com/package/heor-agent-mcp
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- **GitHub:** https://github.com/neptun2000/
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- **
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- **GitHub:** https://github.com/neptun2000/heor-agent-mcp
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- **Smithery:** https://smithery.ai/servers/neptun2000-70zu/heor-agent-mcp
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- **Web UI:** https://web-michael-ns-projects.vercel.app
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- **Issues:** https://github.com/neptun2000/heor-agent-mcp/issues
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package/dist/models/psa.d.ts.map
CHANGED
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@@ -1 +1 @@
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{"version":3,"file":"psa.d.ts","sourceRoot":"","sources":["../../src/models/psa.ts"],"names":[],"mappings":"AAAA;;GAEG;AAEH,OAAO,KAAK,EAAE,aAAa,EAAE,MAAM,uBAAuB,CAAC;
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{"version":3,"file":"psa.d.ts","sourceRoot":"","sources":["../../src/models/psa.ts"],"names":[],"mappings":"AAAA;;GAEG;AAEH,OAAO,KAAK,EAAE,aAAa,EAAE,MAAM,uBAAuB,CAAC;AAO3D,MAAM,MAAM,aAAa,GAAG,aAAa,CAAC;AAE1C,MAAM,WAAW,SAAS;IACxB,WAAW,EAAE,aAAa,CAAC;IAC3B,YAAY,EAAE,MAAM,CAAC;IACrB,IAAI,CAAC,EAAE,MAAM,CAAC;CACf;AAED,MAAM,WAAW,YAAY;IAC3B,UAAU,EAAE,MAAM,CAAC;IACnB,UAAU,EAAE,MAAM,CAAC;IACnB,IAAI,EAAE,MAAM,CAAC;CACd;AAED,MAAM,WAAW,SAAS;IACxB,UAAU,EAAE,YAAY,EAAE,CAAC;IAC3B,SAAS,EAAE,MAAM,CAAC;IAClB,aAAa,EAAE,MAAM,CAAC;IACtB,aAAa,EAAE,MAAM,CAAC;IACtB,mBAAmB,EAAE,MAAM,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IAC5C,IAAI,EAAE,KAAK,CAAC;QAAE,GAAG,EAAE,MAAM,CAAC;QAAC,OAAO,EAAE,MAAM,CAAA;KAAE,CAAC,CAAC;IAC9C,IAAI,EAAE,MAAM,CAAC;IACb,cAAc,EAAE,YAAY,EAAE,CAAC;CAChC;AAiCD;;GAEG;AACH,wBAAgB,MAAM,CAAC,MAAM,EAAE,SAAS,GAAG,SAAS,CA8InD"}
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package/dist/models/psa.js
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* Probabilistic Sensitivity Analysis (PSA) using Monte Carlo simulation.
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*/
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import { betaSample, gammaSample, createSeededRng } from "./distributions.js";
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import { runMarkovAndComputeICER } from "./modelUtils.js";
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import { runMarkovAndComputeICER, } from "./modelUtils.js";
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const WTP_THRESHOLDS_PSA = {
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nhs_low:
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nhs_high:
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nhs_low: 25000,
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nhs_high: 35000,
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us_payer_low: 100000,
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us_payer_mid: 150000,
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societal: 50000,
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...params.base_params,
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clinical_inputs: {
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...params.base_params.clinical_inputs,
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efficacy_delta: perturbBeta(Math.max(0.001, Math.min(0.999, params.base_params.clinical_inputs.efficacy_delta)), 0.
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efficacy_delta: perturbBeta(Math.max(0.001, Math.min(0.999, params.base_params.clinical_inputs.efficacy_delta)), 0.1, rng),
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mortality_reduction: params.base_params.clinical_inputs.mortality_reduction !== undefined
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? perturbBeta(Math.max(0.001, Math.min(0.999, params.base_params.clinical_inputs.mortality_reduction)), 0.
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? perturbBeta(Math.max(0.001, Math.min(0.999, params.base_params.clinical_inputs.mortality_reduction)), 0.1, rng)
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: undefined,
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},
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cost_inputs: {
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drug_cost_annual: perturbGamma(params.base_params.cost_inputs.drug_cost_annual, 0.
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comparator_cost_annual: perturbGamma(params.base_params.cost_inputs.comparator_cost_annual, 0.
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drug_cost_annual: perturbGamma(params.base_params.cost_inputs.drug_cost_annual, 0.2, rng),
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comparator_cost_annual: perturbGamma(params.base_params.cost_inputs.comparator_cost_annual, 0.2, rng),
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admin_cost: params.base_params.cost_inputs.admin_cost !== undefined
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? perturbGamma(params.base_params.cost_inputs.admin_cost, 0.
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? perturbGamma(params.base_params.cost_inputs.admin_cost, 0.2, rng)
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: undefined,
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ae_cost: params.base_params.cost_inputs.ae_cost !== undefined
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? perturbGamma(params.base_params.cost_inputs.ae_cost, 0.
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? perturbGamma(params.base_params.cost_inputs.ae_cost, 0.2, rng)
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: undefined,
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},
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utility_inputs: params.base_params.utility_inputs
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iterations.push({ delta_cost, delta_qaly, icer });
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}
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// Compute statistics
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const finiteICERs = iterations
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const finiteICERs = iterations
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.map((it) => it.icer)
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.filter((ic) => isFinite(ic));
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const sortedICERs = [...finiteICERs].sort((a, b) => a - b);
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const mean_icer = finiteICERs.length > 0
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? finiteICERs.reduce((a, b) => a + b, 0) / finiteICERs.length
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: Infinity;
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const ci_icer_lower = sortedICERs.length > 0
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? sortedICERs[Math.floor(sortedICERs.length * 0.025)] ?? sortedICERs[0]
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? (sortedICERs[Math.floor(sortedICERs.length * 0.025)] ?? sortedICERs[0])
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: 0;
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const ci_icer_upper = sortedICERs.length > 0
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? sortedICERs[Math.floor(sortedICERs.length * 0.975)] ??
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? (sortedICERs[Math.floor(sortedICERs.length * 0.975)] ??
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sortedICERs[sortedICERs.length - 1])
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: 0;
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// Probability cost-effective at named thresholds
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const prob_cost_effective = {};
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for (const [name, wtp] of Object.entries(WTP_THRESHOLDS_PSA)) {
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const n_ce = iterations.filter(it => wtp * it.delta_qaly - it.delta_cost > 0).length;
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const n_ce = iterations.filter((it) => wtp * it.delta_qaly - it.delta_cost > 0).length;
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prob_cost_effective[name] = n_ce / iterations.length;
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}
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// CEAC: WTP from $0 to $300,000 in $5,000 steps
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const ceac = [];
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for (let wtp = 0; wtp <= 300000; wtp += 5000) {
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const n_ce = iterations.filter(it => wtp * it.delta_qaly - it.delta_cost > 0).length;
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const n_ce = iterations.filter((it) => wtp * it.delta_qaly - it.delta_cost > 0).length;
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ceac.push({ wtp, prob_ce: n_ce / iterations.length });
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}
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// EVPI: E[max_arm(NMB)] - max_arm(E[NMB])
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package/dist/models/psa.js.map
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{"version":3,"file":"psa.js","sourceRoot":"","sources":["../../src/models/psa.ts"],"names":[],"mappings":"AAAA;;GAEG;AAGH,OAAO,EAAE,UAAU,EAAE,WAAW,EAAE,eAAe,EAAE,MAAM,oBAAoB,CAAC;AAC9E,OAAO,
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{"version":3,"file":"psa.js","sourceRoot":"","sources":["../../src/models/psa.ts"],"names":[],"mappings":"AAAA;;GAEG;AAGH,OAAO,EAAE,UAAU,EAAE,WAAW,EAAE,eAAe,EAAE,MAAM,oBAAoB,CAAC;AAC9E,OAAO,EAEL,uBAAuB,GACxB,MAAM,iBAAiB,CAAC;AA2BzB,MAAM,kBAAkB,GAA2B;IACjD,OAAO,EAAE,KAAK;IACd,QAAQ,EAAE,KAAK;IACf,YAAY,EAAE,MAAM;IACpB,YAAY,EAAE,MAAM;IACpB,QAAQ,EAAE,KAAK;CAChB,CAAC;AAEF;;;GAGG;AACH,SAAS,WAAW,CAAC,KAAa,EAAE,EAAU,EAAE,GAAiB;IAC/D,MAAM,IAAI,GAAG,IAAI,CAAC,GAAG,CAAC,KAAK,EAAE,IAAI,CAAC,GAAG,CAAC,KAAK,EAAE,KAAK,CAAC,CAAC,CAAC;IACrD,MAAM,QAAQ,GAAG,IAAI,CAAC,GAAG,CAAC,IAAI,GAAG,EAAE,EAAE,CAAC,CAAC,CAAC;IACxC,4CAA4C;IAC5C,MAAM,WAAW,GAAG,IAAI,GAAG,CAAC,CAAC,GAAG,IAAI,CAAC,GAAG,IAAI,CAAC;IAC7C,MAAM,YAAY,GAAG,IAAI,CAAC,GAAG,CAAC,QAAQ,EAAE,WAAW,CAAC,CAAC;IACrD,OAAO,UAAU,CAAC,IAAI,EAAE,YAAY,EAAE,GAAG,CAAC,CAAC;AAC7C,CAAC;AAED;;;GAGG;AACH,SAAS,YAAY,CAAC,KAAa,EAAE,EAAU,EAAE,GAAiB;IAChE,MAAM,IAAI,GAAG,IAAI,CAAC,GAAG,CAAC,CAAC,EAAE,KAAK,CAAC,CAAC;IAChC,MAAM,QAAQ,GAAG,IAAI,CAAC,GAAG,CAAC,IAAI,GAAG,EAAE,EAAE,CAAC,CAAC,CAAC;IACxC,OAAO,WAAW,CAAC,IAAI,EAAE,QAAQ,EAAE,GAAG,CAAC,CAAC;AAC1C,CAAC;AAED;;GAEG;AACH,MAAM,UAAU,MAAM,CAAC,MAAiB;IACtC,MAAM,GAAG,GAAG,eAAe,CAAC,MAAM,CAAC,IAAI,IAAI,EAAE,CAAC,CAAC;IAC/C,MAAM,UAAU,GAAmB,EAAE,CAAC;IAEtC,KAAK,IAAI,CAAC,GAAG,CAAC,EAAE,CAAC,GAAG,MAAM,CAAC,YAAY,EAAE,CAAC,EAAE,EAAE,CAAC;QAC7C,8BAA8B;QAC9B,MAAM,eAAe,GAAkB;YACrC,GAAG,MAAM,CAAC,WAAW;YACrB,eAAe,EAAE;gBACf,GAAG,MAAM,CAAC,WAAW,CAAC,eAAe;gBACrC,cAAc,EAAE,WAAW,CACzB,IAAI,CAAC,GAAG,CACN,KAAK,EACL,IAAI,CAAC,GAAG,CAAC,KAAK,EAAE,MAAM,CAAC,WAAW,CAAC,eAAe,CAAC,cAAc,CAAC,CACnE,EACD,GAAG,EACH,GAAG,CACJ;gBACD,mBAAmB,EACjB,MAAM,CAAC,WAAW,CAAC,eAAe,CAAC,mBAAmB,KAAK,SAAS;oBAClE,CAAC,CAAC,WAAW,CACT,IAAI,CAAC,GAAG,CACN,KAAK,EACL,IAAI,CAAC,GAAG,CACN,KAAK,EACL,MAAM,CAAC,WAAW,CAAC,eAAe,CAAC,mBAAmB,CACvD,CACF,EACD,GAAG,EACH,GAAG,CACJ;oBACH,CAAC,CAAC,SAAS;aAChB;YACD,WAAW,EAAE;gBACX,gBAAgB,EAAE,YAAY,CAC5B,MAAM,CAAC,WAAW,CAAC,WAAW,CAAC,gBAAgB,EAC/C,GAAG,EACH,GAAG,CACJ;gBACD,sBAAsB,EAAE,YAAY,CAClC,MAAM,CAAC,WAAW,CAAC,WAAW,CAAC,sBAAsB,EACrD,GAAG,EACH,GAAG,CACJ;gBACD,UAAU,EACR,MAAM,CAAC,WAAW,CAAC,WAAW,CAAC,UAAU,KAAK,SAAS;oBACrD,CAAC,CAAC,YAAY,CAAC,MAAM,CAAC,WAAW,CAAC,WAAW,CAAC,UAAU,EAAE,GAAG,EAAE,GAAG,CAAC;oBACnE,CAAC,CAAC,SAAS;gBACf,OAAO,EACL,MAAM,CAAC,WAAW,CAAC,WAAW,CAAC,OAAO,KAAK,SAAS;oBAClD,CAAC,CAAC,YAAY,CAAC,MAAM,CAAC,WAAW,CAAC,WAAW,CAAC,OAAO,EAAE,GAAG,EAAE,GAAG,CAAC;oBAChE,CAAC,CAAC,SAAS;aAChB;YACD,cAAc,EAAE,MAAM,CAAC,WAAW,CAAC,cAAc;gBAC/C,CAAC,CAAC;oBACE,iBAAiB,EAAE,WAAW,CAC5B,MAAM,CAAC,WAAW,CAAC,cAAc,CAAC,iBAAiB,EACnD,IAAI,EACJ,GAAG,CACJ;oBACD,eAAe,EAAE,WAAW,CAC1B,MAAM,CAAC,WAAW,CAAC,cAAc,CAAC,eAAe,EACjD,IAAI,EACJ,GAAG,CACJ;iBACF;gBACH,CAAC,CAAC,SAAS;SACd,CAAC;QAEF,MAAM,EAAE,UAAU,EAAE,UAAU,EAAE,IAAI,EAAE,GACpC,uBAAuB,CAAC,eAAe,CAAC,CAAC;QAC3C,UAAU,CAAC,IAAI,CAAC,EAAE,UAAU,EAAE,UAAU,EAAE,IAAI,EAAE,CAAC,CAAC;IACpD,CAAC;IAED,qBAAqB;IACrB,MAAM,WAAW,GAAG,UAAU;SAC3B,GAAG,CAAC,CAAC,EAAE,EAAE,EAAE,CAAC,EAAE,CAAC,IAAI,CAAC;SACpB,MAAM,CAAC,CAAC,EAAE,EAAE,EAAE,CAAC,QAAQ,CAAC,EAAE,CAAC,CAAC,CAAC;IAChC,MAAM,WAAW,GAAG,CAAC,GAAG,WAAW,CAAC,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC;IAE3D,MAAM,SAAS,GACb,WAAW,CAAC,MAAM,GAAG,CAAC;QACpB,CAAC,CAAC,WAAW,CAAC,MAAM,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC,GAAG,CAAC,EAAE,CAAC,CAAC,GAAG,WAAW,CAAC,MAAM;QAC7D,CAAC,CAAC,QAAQ,CAAC;IAEf,MAAM,aAAa,GACjB,WAAW,CAAC,MAAM,GAAG,CAAC;QACpB,CAAC,CAAC,CAAC,WAAW,CAAC,IAAI,CAAC,KAAK,CAAC,WAAW,CAAC,MAAM,GAAG,KAAK,CAAC,CAAC,IAAI,WAAW,CAAC,CAAC,CAAE,CAAC;QAC1E,CAAC,CAAC,CAAC,CAAC;IACR,MAAM,aAAa,GACjB,WAAW,CAAC,MAAM,GAAG,CAAC;QACpB,CAAC,CAAC,CAAC,WAAW,CAAC,IAAI,CAAC,KAAK,CAAC,WAAW,CAAC,MAAM,GAAG,KAAK,CAAC,CAAC;YACpD,WAAW,CAAC,WAAW,CAAC,MAAM,GAAG,CAAC,CAAE,CAAC;QACvC,CAAC,CAAC,CAAC,CAAC;IAER,iDAAiD;IACjD,MAAM,mBAAmB,GAA2B,EAAE,CAAC;IACvD,KAAK,MAAM,CAAC,IAAI,EAAE,GAAG,CAAC,IAAI,MAAM,CAAC,OAAO,CAAC,kBAAkB,CAAC,EAAE,CAAC;QAC7D,MAAM,IAAI,GAAG,UAAU,CAAC,MAAM,CAC5B,CAAC,EAAE,EAAE,EAAE,CAAC,GAAG,GAAG,EAAE,CAAC,UAAU,GAAG,EAAE,CAAC,UAAU,GAAG,CAAC,CAChD,CAAC,MAAM,CAAC;QACT,mBAAmB,CAAC,IAAI,CAAC,GAAG,IAAI,GAAG,UAAU,CAAC,MAAM,CAAC;IACvD,CAAC;IAED,gDAAgD;IAChD,MAAM,IAAI,GAA4C,EAAE,CAAC;IACzD,KAAK,IAAI,GAAG,GAAG,CAAC,EAAE,GAAG,IAAI,MAAM,EAAE,GAAG,IAAI,IAAI,EAAE,CAAC;QAC7C,MAAM,IAAI,GAAG,UAAU,CAAC,MAAM,CAC5B,CAAC,EAAE,EAAE,EAAE,CAAC,GAAG,GAAG,EAAE,CAAC,UAAU,GAAG,EAAE,CAAC,UAAU,GAAG,CAAC,CAChD,CAAC,MAAM,CAAC;QACT,IAAI,CAAC,IAAI,CAAC,EAAE,GAAG,EAAE,OAAO,EAAE,IAAI,GAAG,UAAU,CAAC,MAAM,EAAE,CAAC,CAAC;IACxD,CAAC;IAED,0CAA0C;IAC1C,iEAAiE;IACjE,MAAM,MAAM,GAAG,KAAK,CAAC;IACrB,MAAM,qBAAqB,GACzB,UAAU,CAAC,MAAM,CACf,CAAC,GAAG,EAAE,EAAE,EAAE,EAAE,CAAC,GAAG,GAAG,CAAC,MAAM,GAAG,EAAE,CAAC,UAAU,GAAG,EAAE,CAAC,UAAU,CAAC,EAC3D,CAAC,CACF,GAAG,UAAU,CAAC,MAAM,CAAC;IACxB,MAAM,mBAAmB,GAAG,CAAC,CAAC,CAAC,sCAAsC;IACrE,MAAM,SAAS,GACb,UAAU,CAAC,MAAM,CAAC,CAAC,GAAG,EAAE,EAAE,EAAE,EAAE;QAC5B,MAAM,OAAO,GAAG,MAAM,GAAG,EAAE,CAAC,UAAU,GAAG,EAAE,CAAC,UAAU,CAAC;QACvD,OAAO,GAAG,GAAG,IAAI,CAAC,GAAG,CAAC,OAAO,EAAE,mBAAmB,CAAC,CAAC;IACtD,CAAC,EAAE,CAAC,CAAC,GAAG,UAAU,CAAC,MAAM,CAAC;IAC5B,MAAM,SAAS,GAAG,IAAI,CAAC,GAAG,CAAC,qBAAqB,EAAE,mBAAmB,CAAC,CAAC;IACvE,MAAM,IAAI,GAAG,IAAI,CAAC,GAAG,CAAC,CAAC,EAAE,SAAS,GAAG,SAAS,CAAC,CAAC;IAEhD,MAAM,cAAc,GAAG,UAAU,CAAC,KAAK,CAAC,CAAC,EAAE,GAAG,CAAC,CAAC;IAEhD,OAAO;QACL,UAAU;QACV,SAAS;QACT,aAAa;QACb,aAAa;QACb,mBAAmB;QACnB,IAAI;QACJ,IAAI;QACJ,cAAc;KACf,CAAC;AACJ,CAAC"}
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export async function fetchCadthReviews(query, maxResults) {
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const entries = [
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{
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title: `
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abstract: `
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url: `https://www.
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title: `CDA-AMC (formerly CADTH) Reimbursement Reviews: ${query}`,
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abstract: `CDA-AMC (Canada's Drug Agency, formerly CADTH) provides independent health technology assessments for reimbursement decisions across Canadian provinces. Includes Common Drug Review (CDR) and pan-Canadian Oncology Drug Review (pCODR) with clinical evidence summaries, pharmacoeconomic reviews, and formulary recommendations. Search "${query}" to find past reimbursement decisions relevant to the drug or indication. Key for benchmarking Canadian market access strategy.`,
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url: `https://www.cda-amc.ca/reimbursement-reviews-search?search_api_fulltext=${encodeURIComponent(query)}`,
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},
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{
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title: `
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title: `CDA-AMC Pan-Canadian Oncology Drug Review (pCODR)`,
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abstract: `pCODR reviews oncology drugs for reimbursement across Canada. Includes initial and resubmission reviews with clinical and pharmacoeconomic summaries, expert committee recommendations, and pan-Canadian reimbursement conditions. Essential for oncology HTA submissions targeting Canadian payers.`,
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url: "https://www.
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url: "https://www.cda-amc.ca/pcodr",
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},
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{
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title: `
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abstract: `
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url: "https://www.
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title: `CDA-AMC Methods and Guidelines`,
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abstract: `CDA-AMC's methodological guidelines for health technology assessments, including pharmacoeconomic guidelines for Canada. Covers modelling standards, utility values, costs, willingness-to-pay thresholds, and indirect treatment comparisons. Required reference for preparing Canadian HTA submissions.`,
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url: "https://www.cda-amc.ca/methods-and-guidelines",
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},
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];
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return entries.slice(0, maxResults).map((e, i) => ({
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id: `cadth_reviews_${i}`,
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source: "cadth_reviews",
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title: e.title,
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authors: ["
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authors: ["CDA-AMC — Canada's Drug Agency (formerly CADTH)"],
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date: new Date().getFullYear().toString(),
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study_type: "hta_report",
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abstract: e.abstract,
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-
{"version":3,"file":"cadthReviews.js","sourceRoot":"","sources":["../../../src/providers/direct/cadthReviews.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,iBAAiB,CAAC,KAAa,EAAE,UAAkB;IACvE,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,
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+
{"version":3,"file":"cadthReviews.js","sourceRoot":"","sources":["../../../src/providers/direct/cadthReviews.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,iBAAiB,CAAC,KAAa,EAAE,UAAkB;IACvE,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,mDAAmD,KAAK,EAAE;YACjE,QAAQ,EAAE,+UAA+U,KAAK,kIAAkI;YAChe,GAAG,EAAE,2EAA2E,kBAAkB,CAAC,KAAK,CAAC,EAAE;SAC5G;QACD;YACE,KAAK,EAAE,mDAAmD;YAC1D,QAAQ,EAAE,sSAAsS;YAChT,GAAG,EAAE,8BAA8B;SACpC;QACD;YACE,KAAK,EAAE,gCAAgC;YACvC,QAAQ,EAAE,2SAA2S;YACrT,GAAG,EAAE,+CAA+C;SACrD;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,iBAAiB,CAAC,EAAE;QACxB,MAAM,EAAE,eAAwB;QAChC,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,iDAAiD,CAAC;QAC5D,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
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@@ -1 +1 @@
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-
{"version":3,"file":"icerReports.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/icerReports.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,gBAAgB,
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+
{"version":3,"file":"icerReports.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/icerReports.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,gBAAgB,CACpC,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6B7B"}
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@@ -6,7 +6,7 @@ export async function fetchIcerReports(query, maxResults) {
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url: `https://icer.org/?s=${encodeURIComponent(query)}`,
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},
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{
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title: `ICER Value Assessment Framework 2023`,
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title: `ICER Value Assessment Framework 2023-2026`,
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abstract: `ICER's Value Assessment Framework describes the methods used in all ICER evidence reports. Covers clinical benefit rating, comparative value rating, incremental cost-effectiveness ratios, health-benefit price benchmarks, and budget impact analysis. Essential reading for understanding ICER's standards and preparing for ICER engagement.`,
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url: "https://icer.org/our-approach/methods-process/value-assessment-framework/",
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},
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@@ -1 +1 @@
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-
{"version":3,"file":"icerReports.js","sourceRoot":"","sources":["../../../src/providers/direct/icerReports.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,gBAAgB,
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+
{"version":3,"file":"icerReports.js","sourceRoot":"","sources":["../../../src/providers/direct/icerReports.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,gBAAgB,CACpC,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,sTAAsT,KAAK,iIAAiI;YACtc,GAAG,EAAE,uBAAuB,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACxD;QACD;YACE,KAAK,EAAE,2CAA2C;YAClD,QAAQ,EAAE,kVAAkV;YAC5V,GAAG,EAAE,2EAA2E;SACjF;QACD;YACE,KAAK,EAAE,6CAA6C;YACpD,QAAQ,EAAE,uVAAuV;YACjW,GAAG,EAAE,6EAA6E;SACnF;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,gBAAgB,CAAC,EAAE;QACvB,MAAM,EAAE,cAAuB;QAC/B,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,mDAAmD,CAAC;QAC9D,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
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@@ -1 +1 @@
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1
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-
{"version":3,"file":"iqwig.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/iqwig.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,UAAU,
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1
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+
{"version":3,"file":"iqwig.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/iqwig.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,UAAU,CAC9B,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA+B7B"}
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@@ -6,8 +6,8 @@ export async function fetchIqwig(query, maxResults) {
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6
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url: `https://www.iqwig.de/en/projects/?tab=search&query=${encodeURIComponent(query)}`,
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},
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{
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title: `IQWiG General Methods
|
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abstract: `IQWiG's General Methods document describes its methodological standards for health technology assessments and benefit evaluations. Covers systematic review methodology, GRADE-like evidence rating, indirect comparisons, patient-relevant endpoints, and the efficiency frontier approach for cost-benefit analysis. Key reference for understanding IQWiG's evidence standards.`,
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title: `IQWiG General Methods v8.0 (2025)`,
|
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+
abstract: `IQWiG's General Methods document describes its methodological standards for health technology assessments and benefit evaluations. Version 8.0 (2025) supersedes v7.0 (2023). Covers systematic review methodology, GRADE-like evidence rating, indirect comparisons, patient-relevant endpoints, and the efficiency frontier approach for cost-benefit analysis. Key reference for understanding IQWiG's evidence standards.`,
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url: "https://www.iqwig.de/en/about-us/methods/methods-paper/",
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},
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{
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@@ -20,7 +20,9 @@ export async function fetchIqwig(query, maxResults) {
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id: `iqwig_${i}`,
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source: "iqwig",
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title: e.title,
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authors: [
|
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authors: [
|
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"Institute for Quality and Efficiency in Health Care (IQWiG), Germany",
|
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],
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date: new Date().getFullYear().toString(),
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study_type: "hta_report",
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abstract: e.abstract,
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@@ -1 +1 @@
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-
{"version":3,"file":"iqwig.js","sourceRoot":"","sources":["../../../src/providers/direct/iqwig.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,UAAU,
|
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1
|
+
{"version":3,"file":"iqwig.js","sourceRoot":"","sources":["../../../src/providers/direct/iqwig.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,UAAU,CAC9B,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,0PAA0P,KAAK,yKAAyK;YAClb,GAAG,EAAE,sDAAsD,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACvF;QACD;YACE,KAAK,EAAE,mCAAmC;YAC1C,QAAQ,EAAE,+ZAA+Z;YACza,GAAG,EAAE,yDAAyD;SAC/D;QACD;YACE,KAAK,EAAE,wCAAwC;YAC/C,QAAQ,EAAE,wUAAwU;YAClV,GAAG,EAAE,2DAA2D;SACjE;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,SAAS,CAAC,EAAE;QAChB,MAAM,EAAE,OAAgB;QACxB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE;YACP,sEAAsE;SACvE;QACD,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"niceTa.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/niceTa.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,WAAW,
|
|
1
|
+
{"version":3,"file":"niceTa.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/niceTa.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,WAAW,CAC/B,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6B7B"}
|
|
@@ -7,7 +7,7 @@ export async function fetchNiceTa(query, maxResults) {
|
|
|
7
7
|
},
|
|
8
8
|
{
|
|
9
9
|
title: `NICE Single Technology Appraisal Process Guide`,
|
|
10
|
-
abstract: `NICE's STA methodology guide PMG36 and process guide PMG19. Required reading for company submissions. Covers reference case, time horizon, discount rates (3.5%), perspective (NHS+PSS), ICER threshold (£
|
|
10
|
+
abstract: `NICE's STA methodology guide PMG36 and process guide PMG19. Required reading for company submissions. Covers reference case, time horizon, discount rates (3.5%), perspective (NHS+PSS), ICER threshold (£25–35K/QALY, updated April 2026), end-of-life criteria, and innovation rating.`,
|
|
11
11
|
url: "https://www.nice.org.uk/process/pmg36",
|
|
12
12
|
},
|
|
13
13
|
{
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"niceTa.js","sourceRoot":"","sources":["../../../src/providers/direct/niceTa.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,WAAW,
|
|
1
|
+
{"version":3,"file":"niceTa.js","sourceRoot":"","sources":["../../../src/providers/direct/niceTa.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,WAAW,CAC/B,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,sCAAsC,KAAK,EAAE;YACpD,QAAQ,EAAE,oPAAoP,KAAK,yJAAyJ;YAC5Z,GAAG,EAAE,oCAAoC,kBAAkB,CAAC,KAAK,CAAC,wDAAwD;SAC3H;QACD;YACE,KAAK,EAAE,gDAAgD;YACvD,QAAQ,EAAE,0RAA0R;YACpS,GAAG,EAAE,uCAAuC;SAC7C;QACD;YACE,KAAK,EAAE,+BAA+B;YACtC,QAAQ,EAAE,wNAAwN;YAClO,GAAG,EAAE,0EAA0E;SAChF;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,WAAW,CAAC,EAAE;QAClB,MAAM,EAAE,SAAkB;QAC1B,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,0DAA0D,CAAC;QACrE,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"pbacPsd.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/pbacPsd.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,YAAY,
|
|
1
|
+
{"version":3,"file":"pbacPsd.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/pbacPsd.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,YAAY,CAChC,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6B7B"}
|
|
@@ -7,7 +7,7 @@ export async function fetchPbacPsd(query, maxResults) {
|
|
|
7
7
|
},
|
|
8
8
|
{
|
|
9
9
|
title: `PBAC Guidelines 5.0 (2016)`,
|
|
10
|
-
abstract: `PBAC guidelines for preparing drug submissions, covering cost-minimisation, cost-effectiveness, and cost-utility analyses. Describes PBAC's preferred methods: incremental analysis, QALYs, discount rate (5%), perspective (health system)
|
|
10
|
+
abstract: `PBAC guidelines for preparing drug submissions, covering cost-minimisation, cost-effectiveness, and cost-utility analyses. Describes PBAC's preferred methods: incremental analysis, QALYs, discount rate (5%), perspective (health system). PBAC has no formal WTP threshold but the implicit threshold is approximately AUD 50K/QALY. Required reference for PBS submissions.`,
|
|
11
11
|
url: "https://pbac.pbs.gov.au/",
|
|
12
12
|
},
|
|
13
13
|
{
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"pbacPsd.js","sourceRoot":"","sources":["../../../src/providers/direct/pbacPsd.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,YAAY,
|
|
1
|
+
{"version":3,"file":"pbacPsd.js","sourceRoot":"","sources":["../../../src/providers/direct/pbacPsd.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,YAAY,CAChC,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,kCAAkC,KAAK,EAAE;YAChD,QAAQ,EAAE,kUAAkU,KAAK,0IAA0I;YAC3d,GAAG,EAAE,kFAAkF,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACnH;QACD;YACE,KAAK,EAAE,4BAA4B;YACnC,QAAQ,EAAE,iXAAiX;YAC3X,GAAG,EAAE,0BAA0B;SAChC;QACD;YACE,KAAK,EAAE,+BAA+B;YACtC,QAAQ,EAAE,gRAAgR;YAC1R,GAAG,EAAE,mFAAmF;SACzF;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,YAAY,CAAC,EAAE;QACnB,MAAM,EAAE,UAAmB;QAC3B,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,8DAA8D,CAAC;QACzE,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"tlv.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/tlv.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,QAAQ,
|
|
1
|
+
{"version":3,"file":"tlv.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/tlv.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,QAAQ,CAC5B,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA+B7B"}
|
|
@@ -7,7 +7,7 @@ export async function fetchTlv(query, maxResults) {
|
|
|
7
7
|
},
|
|
8
8
|
{
|
|
9
9
|
title: `TLV General Guidelines for Economic Evaluations`,
|
|
10
|
-
abstract: `TLV's guidelines for health economic evaluations submitted in support of reimbursement applications. Covers cost-effectiveness analysis
|
|
10
|
+
abstract: `TLV's guidelines for health economic evaluations submitted in support of reimbursement applications. Covers cost-effectiveness analysis with severity-tiered WTP thresholds: ~SEK 250K/QALY (low severity), ~SEK 500K (medium), ~SEK 750K (high), ~SEK 1M (very high severity). QALY methodology, societal perspective, 3% discount rate, and uncertainty analysis requirements. Required reading for Swedish HTA submissions.`,
|
|
11
11
|
url: "https://www.tlv.se/in-english/medicines/general-guidelines-for-economic-evaluations.html",
|
|
12
12
|
},
|
|
13
13
|
{
|
|
@@ -20,7 +20,9 @@ export async function fetchTlv(query, maxResults) {
|
|
|
20
20
|
id: `tlv_${i}`,
|
|
21
21
|
source: "tlv",
|
|
22
22
|
title: e.title,
|
|
23
|
-
authors: [
|
|
23
|
+
authors: [
|
|
24
|
+
"Tandvårds- och läkemedelsförmånsverket (TLV) — Dental and Pharmaceutical Benefits Agency, Sweden",
|
|
25
|
+
],
|
|
24
26
|
date: new Date().getFullYear().toString(),
|
|
25
27
|
study_type: "hta_report",
|
|
26
28
|
abstract: e.abstract,
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"tlv.js","sourceRoot":"","sources":["../../../src/providers/direct/tlv.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,QAAQ,
|
|
1
|
+
{"version":3,"file":"tlv.js","sourceRoot":"","sources":["../../../src/providers/direct/tlv.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,QAAQ,CAC5B,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,oSAAoS,KAAK,wHAAwH;YAC3a,GAAG,EAAE,mDAAmD,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACpF;QACD;YACE,KAAK,EAAE,iDAAiD;YACxD,QAAQ,EAAE,gaAAga;YAC1a,GAAG,EAAE,0FAA0F;SAChG;QACD;YACE,KAAK,EAAE,mCAAmC;YAC1C,QAAQ,EAAE,qWAAqW;YAC/W,GAAG,EAAE,6CAA6C;SACnD;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,OAAO,CAAC,EAAE;QACd,MAAM,EAAE,KAAc;QACtB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE;YACP,kGAAkG;SACnG;QACD,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
|
package/dist/sources/registry.js
CHANGED
|
@@ -165,9 +165,9 @@ export const SOURCE_REGISTRY = [
|
|
|
165
165
|
},
|
|
166
166
|
{
|
|
167
167
|
id: "cadth_reviews",
|
|
168
|
-
name: "CADTH",
|
|
168
|
+
name: "CDA-AMC (CADTH)",
|
|
169
169
|
category: "hta_appraisal",
|
|
170
|
-
description: "CADTH
|
|
170
|
+
description: "CDA-AMC (formerly CADTH) reimbursement reviews (Canada)",
|
|
171
171
|
regional: "Canada",
|
|
172
172
|
},
|
|
173
173
|
{
|
|
@@ -1 +1 @@
|
|
|
1
|
-
{"version":3,"file":"registry.js","sourceRoot":"","sources":["../../src/sources/registry.ts"],"names":[],"mappings":"AAuBA,MAAM,CAAC,MAAM,eAAe,GAAiB;IAC3C,aAAa;IACb;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,iCAAiC;KAC/C;IACD;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,iBAAiB;QACvB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,sCAAsC;KACpD;IACD;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,6CAA6C;KAC3D;IAED,kBAAkB;IAClB;QACE,EAAE,EAAE,gBAAgB;QACpB,IAAI,EAAE,oBAAoB;QAC1B,QAAQ,EAAE,iBAAiB;QAC3B,WAAW,EAAE,iCAAiC;KAC/C;IAED,eAAe;IACf;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,SAAS;QACf,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,+BAA+B;KAC7C;IACD;QACE,EAAE,EAAE,YAAY;QAChB,IAAI,EAAE,YAAY;QAClB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,yCAAyC;KACvD;IACD;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,+BAA+B;KAC7C;IACD;QACE,EAAE,EAAE,MAAM;QACV,IAAI,EAAE,aAAa;QACnB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,iDAAiD;KAC/D;IACD;QACE,EAAE,EAAE,UAAU;QACd,IAAI,EAAE,UAAU;QAChB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,8CAA8C;KAC5D;IAED,MAAM;IACN;QACE,EAAE,EAAE,aAAa;QACjB,IAAI,EAAE,iBAAiB;QACvB,QAAQ,EAAE,KAAK;QACf,WAAW,EAAE,4CAA4C;KAC1D;IACD;QACE,EAAE,EAAE,aAAa;QACjB,IAAI,EAAE,iBAAiB;QACvB,QAAQ,EAAE,KAAK;QACf,WAAW,EAAE,oCAAoC;KAClD;IAED,gCAAgC;IAChC;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,8BAA8B;QAC3C,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,eAAe;QACnB,IAAI,EAAE,eAAe;QACrB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,qDAAqD;QAClE,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,UAAU;QACd,IAAI,EAAE,kBAAkB;QACxB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,sCAAsC;QACnD,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,UAAU;QACd,IAAI,EAAE,UAAU;QAChB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,8BAA8B;QAC3C,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,eAAe;QACnB,IAAI,EAAE,eAAe;QACrB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,2BAA2B;QACxC,WAAW,EAAE,uBAAuB;KACrC;IACD;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,4CAA4C;QACzD,WAAW,EAAE,mBAAmB;KACjC;IACD;QACE,EAAE,EAAE,gBAAgB;QACpB,IAAI,EAAE,gBAAgB;QACtB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,wBAAwB;QACrC,WAAW,EAAE,aAAa;KAC3B;IAED,sBAAsB;IACtB;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,qCAAqC;QAClD,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,OAAO;QACX,IAAI,EAAE,OAAO;QACb,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,yCAAyC;QACtD,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,8BAA8B;QAC3C,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,KAAK;QACT,IAAI,EAAE,KAAK;QACX,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,yCAAyC;QACtD,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,cAAc;QAClB,IAAI,EAAE,cAAc;QACpB,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,2BAA2B;QACxC,QAAQ,EAAE,WAAW;KACtB;IAED,iBAAiB;IACjB;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,UAAU;QAChB,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,iCAAiC;QAC9C,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,eAAe;QACnB,IAAI,EAAE,
|
|
1
|
+
{"version":3,"file":"registry.js","sourceRoot":"","sources":["../../src/sources/registry.ts"],"names":[],"mappings":"AAuBA,MAAM,CAAC,MAAM,eAAe,GAAiB;IAC3C,aAAa;IACb;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,iCAAiC;KAC/C;IACD;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,iBAAiB;QACvB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,sCAAsC;KACpD;IACD;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,6CAA6C;KAC3D;IAED,kBAAkB;IAClB;QACE,EAAE,EAAE,gBAAgB;QACpB,IAAI,EAAE,oBAAoB;QAC1B,QAAQ,EAAE,iBAAiB;QAC3B,WAAW,EAAE,iCAAiC;KAC/C;IAED,eAAe;IACf;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,SAAS;QACf,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,+BAA+B;KAC7C;IACD;QACE,EAAE,EAAE,YAAY;QAChB,IAAI,EAAE,YAAY;QAClB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,yCAAyC;KACvD;IACD;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,+BAA+B;KAC7C;IACD;QACE,EAAE,EAAE,MAAM;QACV,IAAI,EAAE,aAAa;QACnB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,iDAAiD;KAC/D;IACD;QACE,EAAE,EAAE,UAAU;QACd,IAAI,EAAE,UAAU;QAChB,QAAQ,EAAE,cAAc;QACxB,WAAW,EAAE,8CAA8C;KAC5D;IAED,MAAM;IACN;QACE,EAAE,EAAE,aAAa;QACjB,IAAI,EAAE,iBAAiB;QACvB,QAAQ,EAAE,KAAK;QACf,WAAW,EAAE,4CAA4C;KAC1D;IACD;QACE,EAAE,EAAE,aAAa;QACjB,IAAI,EAAE,iBAAiB;QACvB,QAAQ,EAAE,KAAK;QACf,WAAW,EAAE,oCAAoC;KAClD;IAED,gCAAgC;IAChC;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,8BAA8B;QAC3C,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,eAAe;QACnB,IAAI,EAAE,eAAe;QACrB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,qDAAqD;QAClE,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,UAAU;QACd,IAAI,EAAE,kBAAkB;QACxB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,sCAAsC;QACnD,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,UAAU;QACd,IAAI,EAAE,UAAU;QAChB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,8BAA8B;QAC3C,WAAW,EAAE,kBAAkB;KAChC;IACD;QACE,EAAE,EAAE,eAAe;QACnB,IAAI,EAAE,eAAe;QACrB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,2BAA2B;QACxC,WAAW,EAAE,uBAAuB;KACrC;IACD;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,4CAA4C;QACzD,WAAW,EAAE,mBAAmB;KACjC;IACD;QACE,EAAE,EAAE,gBAAgB;QACpB,IAAI,EAAE,gBAAgB;QACtB,QAAQ,EAAE,YAAY;QACtB,WAAW,EAAE,wBAAwB;QACrC,WAAW,EAAE,aAAa;KAC3B;IAED,sBAAsB;IACtB;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,qCAAqC;QAClD,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,OAAO;QACX,IAAI,EAAE,OAAO;QACb,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,yCAAyC;QACtD,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,WAAW;QACf,IAAI,EAAE,WAAW;QACjB,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,8BAA8B;QAC3C,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,KAAK;QACT,IAAI,EAAE,KAAK;QACX,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,yCAAyC;QACtD,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,cAAc;QAClB,IAAI,EAAE,cAAc;QACpB,QAAQ,EAAE,UAAU;QACpB,WAAW,EAAE,2BAA2B;QACxC,QAAQ,EAAE,WAAW;KACtB;IAED,iBAAiB;IACjB;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,UAAU;QAChB,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,iCAAiC;QAC9C,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,eAAe;QACnB,IAAI,EAAE,iBAAiB;QACvB,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,yDAAyD;QACtE,QAAQ,EAAE,QAAQ;KACnB;IACD;QACE,EAAE,EAAE,cAAc;QAClB,IAAI,EAAE,MAAM;QACZ,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,sCAAsC;QACnD,QAAQ,EAAE,IAAI;KACf;IACD;QACE,EAAE,EAAE,UAAU;QACd,IAAI,EAAE,MAAM;QACZ,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,2CAA2C;QACxD,QAAQ,EAAE,WAAW;KACtB;IACD;QACE,EAAE,EAAE,eAAe;QACnB,IAAI,EAAE,MAAM;QACZ,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,0CAA0C;QACvD,QAAQ,EAAE,SAAS;KACpB;IACD;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,KAAK;QACX,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,qCAAqC;QAClD,QAAQ,EAAE,QAAQ;KACnB;IACD;QACE,EAAE,EAAE,OAAO;QACX,IAAI,EAAE,OAAO;QACb,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,qCAAqC;QAClD,QAAQ,EAAE,SAAS;KACpB;IACD;QACE,EAAE,EAAE,MAAM;QACV,IAAI,EAAE,MAAM;QACZ,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,sCAAsC;QACnD,QAAQ,EAAE,OAAO;KAClB;IACD;QACE,EAAE,EAAE,KAAK;QACT,IAAI,EAAE,KAAK;QACX,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,gCAAgC;QAC7C,QAAQ,EAAE,QAAQ;KACnB;IACD;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,eAAe;QACzB,WAAW,EAAE,kCAAkC;QAC/C,QAAQ,EAAE,QAAQ;KACnB;IAED,QAAQ;IACR;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,SAAS;QACf,QAAQ,EAAE,OAAO;QACjB,WAAW,EAAE,qCAAqC;QAClD,QAAQ,EAAE,QAAQ;KACnB;IACD;QACE,EAAE,EAAE,SAAS;QACb,IAAI,EAAE,SAAS;QACf,QAAQ,EAAE,OAAO;QACjB,WAAW,EAAE,oBAAoB;QACjC,QAAQ,EAAE,QAAQ;KACnB;IACD;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,OAAO;QACjB,WAAW,EAAE,8BAA8B;QAC3C,QAAQ,EAAE,QAAQ;KACnB;IACD;QACE,EAAE,EAAE,MAAM;QACV,IAAI,EAAE,MAAM;QACZ,QAAQ,EAAE,OAAO;QACjB,WAAW,EAAE,yCAAyC;QACtD,QAAQ,EAAE,OAAO;KAClB;IACD;QACE,EAAE,EAAE,MAAM;QACV,IAAI,EAAE,MAAM;QACZ,QAAQ,EAAE,OAAO;QACjB,WAAW,EAAE,sBAAsB;QACnC,QAAQ,EAAE,UAAU;KACrB;IACD;QACE,EAAE,EAAE,QAAQ;QACZ,IAAI,EAAE,QAAQ;QACd,QAAQ,EAAE,OAAO;QACjB,WAAW,EAAE,oCAAoC;QACjD,QAAQ,EAAE,OAAO;KAClB;IAED,OAAO;IACP;QACE,EAAE,EAAE,OAAO;QACX,IAAI,EAAE,OAAO;QACb,QAAQ,EAAE,MAAM;QAChB,WAAW,EAAE,sBAAsB;QACnC,QAAQ,EAAE,UAAU;KACrB;IAED,QAAQ;IACR;QACE,EAAE,EAAE,OAAO;QACX,IAAI,EAAE,OAAO;QACb,QAAQ,EAAE,OAAO;QACjB,WAAW,EAAE,2CAA2C;KACzD;CACF,CAAC;AAUF,MAAM,UAAU,yBAAyB,CACvC,gBAA8B,EAC9B,aAA2B,eAAe,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,EAAE,CAAC;IAE3D,OAAO,UAAU,CAAC,GAAG,CAAC,CAAC,QAAQ,EAAE,EAAE;QACjC,MAAM,IAAI,GAAG,eAAe,CAAC,IAAI,CAAC,CAAC,CA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@@ -42,7 +42,7 @@ import { contentToDocx } from "../formatters/docx.js";
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42
42
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import { saveReport } from "../knowledge/index.js";
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43
43
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import { saveModelRun } from "../knowledge/index.js";
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44
44
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const WTP_THRESHOLDS = {
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45
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-
nhs: { low:
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45
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+
nhs: { low: 25000, high: 35000, currency: "GBP", symbol: "£" },
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46
46
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us_payer: { low: 100000, high: 150000, currency: "USD", symbol: "$" },
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47
47
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societal: { low: 50000, high: 100000, currency: "USD", symbol: "$" },
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48
48
|
};
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