grnsight 6.0.0 → 6.0.4

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (1024) hide show
  1. package/.eslintrc.yml +2 -0
  2. package/README.md +2 -2
  3. package/database/README.md +87 -1
  4. package/database/expression-database/README.md +60 -0
  5. package/database/expression-database/schema.sql +71 -0
  6. package/database/expression-database/scripts/loader.py +186 -0
  7. package/database/expression-database/scripts/preprocessing.py +197 -0
  8. package/database/network-database/README.md +47 -3
  9. package/database/network-database/schema.sql +3 -2
  10. package/database/network-database/scripts/generate_network.py +4 -18
  11. package/database/network-database/scripts/generate_sgd_network_from_yeastract_network.py +1 -1
  12. package/database/network-database/scripts/loader.py +5 -4
  13. package/gdb/PG_VERSION +1 -0
  14. package/gdb/base/1/112 +0 -0
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  1005. package/server/controllers/additional-sheet-parser.js +2 -2
  1006. package/server/controllers/custom-workbook-controller.js +3 -2
  1007. package/server/controllers/demo-workbooks.js +4 -4
  1008. package/server/controllers/exporters/xlsx.js +29 -52
  1009. package/server/controllers/spreadsheet-controller.js +8 -8
  1010. package/server/dals/expression-dal.js +75 -66
  1011. package/server/dals/network-dal.js +18 -13
  1012. package/test/additional-sheet-parser-tests.js +1 -1
  1013. package/test/export-tests.js +13 -2
  1014. package/test/test.js +56 -19
  1015. package/web-client/public/js/api/grnsight-api.js +68 -104
  1016. package/web-client/public/js/constants.js +1 -1
  1017. package/web-client/public/js/{createNetwork.js → generateNetwork.js} +70 -43
  1018. package/web-client/public/js/grnsight.js +2 -2
  1019. package/web-client/public/js/grnsight.min.js +58 -46
  1020. package/web-client/public/js/setup-load-and-import-handlers.js +181 -169
  1021. package/web-client/public/js/update-app.js +40 -20
  1022. package/web-client/public/js/upload.js +415 -243
  1023. package/web-client/public/stylesheets/grnsight.styl +50 -3
  1024. package/web-client/views/upload.pug +4 -4
package/test/test.js CHANGED
@@ -526,8 +526,8 @@ var twoColumnIdError = function (input, frequency) {
526
526
  var sheet = xlsx.parse(input);
527
527
  var workbook = parseAdditionalSheet(sheet);
528
528
  var twoColumnIdErrorCount = 0;
529
- for (let page in workbook.test) {
530
- twoColumnIdErrorCount += workbook.test[page].errors.filter(function (x) {
529
+ for (let page in workbook.twoColumnSheets) {
530
+ twoColumnIdErrorCount += workbook.twoColumnSheets[page].errors.filter(function (x) {
531
531
  return x.errorCode === "MISLABELED_ID_CELL";
532
532
  }).length;
533
533
  }
@@ -538,8 +538,8 @@ var additionalSheetIncorrectColumnHeaderError = function (input, frequency) {
538
538
  var sheet = xlsx.parse(input);
539
539
  var workbook = parseAdditionalSheet(sheet);
540
540
  var additionalSheetIncorrectColumnHeaderErrorCount = 0;
541
- for (let page in workbook.test) {
542
- additionalSheetIncorrectColumnHeaderErrorCount += workbook.test[page].errors.filter(
541
+ for (let page in workbook.twoColumnSheets) {
542
+ additionalSheetIncorrectColumnHeaderErrorCount += workbook.twoColumnSheets[page].errors.filter(
543
543
  (x) => x.errorCode === "INCORRECT_COLUMN_HEADER").length;
544
544
  }
545
545
  additionalSheetIncorrectColumnHeaderErrorCount += workbook.meta.errors.filter(
@@ -555,8 +555,8 @@ var additionalSheetMissingColumnHeaderError = function (input, frequency) {
555
555
  var sheet = xlsx.parse(input);
556
556
  var workbook = parseAdditionalSheet(sheet);
557
557
  var additionalSheetMissingColumnHeaderErrorCount = 0;
558
- for (let page in workbook.test) {
559
- additionalSheetMissingColumnHeaderErrorCount += workbook.test[page].errors.filter(
558
+ for (let page in workbook.twoColumnSheets) {
559
+ additionalSheetMissingColumnHeaderErrorCount += workbook.twoColumnSheets[page].errors.filter(
560
560
  (x) => x.errorCode === "MISSING_COLUMN_HEADER").length;
561
561
  }
562
562
  additionalSheetMissingColumnHeaderErrorCount += workbook.meta.errors.filter(
@@ -572,8 +572,8 @@ var twoColumnInvalidGeneTypeError = function (input, frequency) {
572
572
  var sheet = xlsx.parse(input);
573
573
  var workbook = parseAdditionalSheet(sheet);
574
574
  var twoColumnInvalidGeneTypeErrorCount = 0;
575
- for (let page in workbook.test) {
576
- twoColumnInvalidGeneTypeErrorCount += workbook.test[page].errors.filter(function (x) {
575
+ for (let page in workbook.twoColumnSheets) {
576
+ twoColumnInvalidGeneTypeErrorCount += workbook.twoColumnSheets[page].errors.filter(function (x) {
577
577
  return x.errorCode === "INVALID_GENE_TYPE";
578
578
  }).length;
579
579
  }
@@ -584,8 +584,8 @@ var twoColumnInvalidValueError = function (input, frequency) {
584
584
  var sheet = xlsx.parse(input);
585
585
  var workbook = parseAdditionalSheet(sheet);
586
586
  var twoColumnInvalidValueErrorCount = 0;
587
- for (let page in workbook.test) {
588
- twoColumnInvalidValueErrorCount += workbook.test[page].errors.filter(function (x) {
587
+ for (let page in workbook.twoColumnSheets) {
588
+ twoColumnInvalidValueErrorCount += workbook.twoColumnSheets[page].errors.filter(function (x) {
589
589
  return x.errorCode === "INVALID_VALUE";
590
590
  }).length;
591
591
  }
@@ -596,8 +596,8 @@ var twoColumnInvalidGeneLengthError = function (input, frequency) {
596
596
  var sheet = xlsx.parse(input);
597
597
  var workbook = parseAdditionalSheet(sheet);
598
598
  var twoColumnInvalidGeneLengthErrorCount = 0;
599
- for (let page in workbook.test) {
600
- twoColumnInvalidGeneLengthErrorCount += workbook.test[page].errors.filter(function (x) {
599
+ for (let page in workbook.twoColumnSheets) {
600
+ twoColumnInvalidGeneLengthErrorCount += workbook.twoColumnSheets[page].errors.filter(function (x) {
601
601
  return x.errorCode === "INVALID_GENE_LENGTH";
602
602
  }).length;
603
603
  }
@@ -608,8 +608,8 @@ var twoColumnSpecialCharacterError = function (input, frequency) {
608
608
  var sheet = xlsx.parse(input);
609
609
  var workbook = parseAdditionalSheet(sheet);
610
610
  var twoColumnSpecialCharacterErrorCount = 0;
611
- for (let page in workbook.test) {
612
- twoColumnSpecialCharacterErrorCount += workbook.test[page].errors.filter(function (x) {
611
+ for (let page in workbook.twoColumnSheets) {
612
+ twoColumnSpecialCharacterErrorCount += workbook.twoColumnSheets[page].errors.filter(function (x) {
613
613
  return x.errorCode === "INVALID_CHARACTER";
614
614
  }).length;
615
615
  }
@@ -622,8 +622,8 @@ var additionalSheetExtraneousDataWarning = function (input, frequency) {
622
622
  var sheet = xlsx.parse(input);
623
623
  var workbook = parseAdditionalSheet(sheet);
624
624
  var additionalSheetExtraneousDataWarningCount = 0;
625
- for (let page in workbook.test) {
626
- additionalSheetExtraneousDataWarningCount += workbook.test[page].warnings.filter(function (x) {
625
+ for (let page in workbook.twoColumnSheets) {
626
+ additionalSheetExtraneousDataWarningCount += workbook.twoColumnSheets[page].warnings.filter(function (x) {
627
627
  return x.warningCode === "EXTRANEOUS_DATA";
628
628
  }).length;
629
629
  }
@@ -716,7 +716,26 @@ var invalidMSEDataWarning = function (input, frequency) {
716
716
  var importExportReImportNoErrorsOrWarnings = function (input) {
717
717
  var sheet = xlsx.parse(input);
718
718
  var inputWorkbook = spreadsheetController.crossSheetInteractions(sheet);
719
- inputWorkbook["exportExpression"] = inputWorkbook.expression;
719
+ inputWorkbook.exportSheets = {
720
+ "optimization_parameters": inputWorkbook.meta,
721
+ expression: inputWorkbook.expression,
722
+ networks: {}
723
+ };
724
+ if (inputWorkbook.network) {
725
+ inputWorkbook.exportSheets.networks["network"] = inputWorkbook.network;
726
+ }
727
+ if (inputWorkbook.networkOptimizedWeights) {
728
+ inputWorkbook.exportSheets.networks["network_optimized_weights"] = inputWorkbook.networkOptimizedWeights;
729
+ }
730
+ if (inputWorkbook.networkWeights) {
731
+ inputWorkbook.exportSheets.networks["network_weights"] = inputWorkbook.networkWeights;
732
+ }
733
+ if (inputWorkbook.twoColumnSheets) {
734
+ inputWorkbook.exportSheets["two_column_sheets"] = inputWorkbook.twoColumnSheets;
735
+ }
736
+ if (inputWorkbook.meta2) {
737
+ inputWorkbook.exportSheets["optimization_diagnostics"] = inputWorkbook.meta2;
738
+ }
720
739
  var exportedWorkbook = exportController.grnsightToXlsx(inputWorkbook);
721
740
  var sheet2 = xlsx.parse(exportedWorkbook);
722
741
  var reImportedWorkbook = spreadsheetController.crossSheetInteractions(sheet2);
@@ -726,8 +745,26 @@ var importExportReImportNoErrorsOrWarnings = function (input) {
726
745
  var importFileSameAsExportFile = function (input) {
727
746
  var sheet = xlsx.parse(input);
728
747
  var inputWorkbook = spreadsheetController.crossSheetInteractions(sheet);
729
- inputWorkbook["exportExpression"] = inputWorkbook.expression;
730
- inputWorkbook["exportNetworkType"] = inputWorkbook.sheetType;
748
+ inputWorkbook.exportSheets = {
749
+ "optimization_parameters": inputWorkbook.meta,
750
+ expression: inputWorkbook.expression,
751
+ networks: {}
752
+ };
753
+ if (inputWorkbook.network) {
754
+ inputWorkbook.exportSheets.networks["network"] = inputWorkbook.network;
755
+ }
756
+ if (inputWorkbook.networkOptimizedWeights) {
757
+ inputWorkbook.exportSheets.networks["network_optimized_weights"] = inputWorkbook.networkOptimizedWeights;
758
+ }
759
+ if (inputWorkbook.networkWeights) {
760
+ inputWorkbook.exportSheets.networks["network_weights"] = inputWorkbook.networkWeights;
761
+ }
762
+ if (inputWorkbook.twoColumnSheets) {
763
+ inputWorkbook.exportSheets["two_column_sheets"] = inputWorkbook.twoColumnSheets;
764
+ }
765
+ if (inputWorkbook.meta2) {
766
+ inputWorkbook.exportSheets["optimization_diagnostics"] = inputWorkbook.meta2;
767
+ }
731
768
  var exportedWorkbook = exportController.grnsightToXlsx(inputWorkbook);
732
769
  var sheet2 = xlsx.parse(exportedWorkbook);
733
770
  sheet.sort((a, b) => (a.name > b.name) ? 1 : -1);
@@ -1,124 +1,88 @@
1
- import {responseCustomWorkbookData} from "../setup-load-and-import-handlers";
2
-
3
- // Expression DB Access Functions
4
- const buildExpressionTimepointsString = function (selection) {
5
- let timepoints = "";
6
- selection.timepoints.forEach(x => timepoints += (x + ","));
7
- return timepoints.substring(0, timepoints.length - 1);
8
- };
9
- const buildExpressionGeneQuery = function (workbookGenes) {
10
- let genes = "";
11
- workbookGenes.forEach(x => genes += (x.name + ","));
12
- return genes.substring(0, genes.length - 1);
1
+ import { responseCustomWorkbookData } from "../setup-load-and-import-handlers";
2
+ // General DB Access Functions
3
+ const buildQueryURL = function(path, parameters) {
4
+ const searchParams = new URLSearchParams("");
5
+ for (let p in parameters) {
6
+ searchParams.append(p, parameters[p]);
7
+ }
8
+ return `${path}?${searchParams.toString()}`;
13
9
  };
14
10
 
15
- const buildExpressionURL = function (selection, genes) {
16
- const baseQuery = `expressiondb?dataset=${selection.dataset}&genes=${buildExpressionGeneQuery(genes)}`;
17
- return selection.timepoints ?
18
- `${baseQuery}&timepoints=${buildExpressionTimepointsString(selection)}` :
19
- baseQuery;
11
+ const responseData = (database, formData, queryURL) => {
12
+ return new Promise(function(resolve) {
13
+ const uploadRoute = queryURL;
14
+ const fullUrl = [$(".service-root").val(), uploadRoute].join("/");
15
+ (formData
16
+ ? $.ajax({
17
+ url: fullUrl,
18
+ data: formData,
19
+ processData: false,
20
+ contentType: false,
21
+ type: "GET",
22
+ crossDomain: true,
23
+ })
24
+ : $.getJSON(fullUrl)
25
+ )
26
+ .done((data) => {
27
+ resolve(data);
28
+ })
29
+ .error(function() {
30
+ console.log(
31
+ `Error in accessing ${database} database. Result may just be loading.`
32
+ );
33
+ });
34
+ });
20
35
  };
21
36
 
22
- const responseExpressionData = (formData, queryURL) => {
23
- return new Promise(function (resolve) {
24
- const uploadRoute = queryURL;
25
- const fullUrl = [ $(".service-root").val(), uploadRoute ].join("/");
26
- (formData ?
27
- $.ajax({
28
- url: fullUrl,
29
- data: formData,
30
- processData: false,
31
- contentType: false,
32
- type: "GET",
33
- crossDomain: true
34
- }) :
35
- $.getJSON(fullUrl)
36
- ).done((expressionData) => {
37
- resolve(expressionData);
38
- }).error(console.log("Error in accessing expression database. Result may just be loading."));
39
- });
40
- };
37
+ // Expression DB Access Functions
41
38
 
42
39
  const queryExpressionDatabase = (query) => {
43
- let queryURL = buildExpressionURL({dataset: query.dataset}, query.genes);
44
- return responseExpressionData("", queryURL);
40
+ const queryURL = buildQueryURL("expressiondb", query);
41
+ return responseData("expression", "", queryURL);
45
42
  };
46
43
 
47
44
  // Network DB Access Functions
48
45
 
49
- const buildNetworkGenesQuery = (genes) => {
50
- let result = "";
51
- for (let gene in genes) {
52
- result += `${gene},`;
53
- }
54
- return result.substring(0, result.length - 1);
46
+ const queryNetworkDatabase = (query) => {
47
+ const queryURL = buildQueryURL("networkdb", query);
48
+ return responseData("network", "", queryURL);
55
49
  };
56
50
 
57
- const buildNetworkURL = function (queryType, queryInfo) {
58
- let baseQuery = `networkdb?type=${queryType}`;
59
- if (queryInfo !== null) {
60
- for (let header in queryInfo) {
61
- if (header === "genes") {
62
- baseQuery += `&${header}=${buildNetworkGenesQuery(queryInfo[header])}`;
63
- } else {
64
- baseQuery += `&${header}=${queryInfo[header]}`;
65
- }
66
- }
67
- }
68
- return baseQuery;
69
- };
51
+ // Upload Custom Workbook Functions
70
52
 
71
- const responseNetworkData = (formData, queryURL) => {
72
- return new Promise(function (resolve) {
73
- const uploadRoute = queryURL;
74
- const fullUrl = [ $(".service-root").val(), uploadRoute ].join("/");
75
- (formData ?
76
- $.ajax({
77
- url: fullUrl,
78
- data: formData,
79
- processData: false,
80
- contentType: false,
81
- type: "GET",
82
- crossDomain: true
83
- }) :
84
- $.getJSON(fullUrl)
85
- ).done((networkData) => {
86
- resolve(networkData);
87
- }).error(console.log("Error in accessing network database. Result may just be loading."));
88
- });
53
+ const uploadCustomWorkbook = (workbook, grnState) => {
54
+ const queryURL = buildQueryURL("upload-custom-workbook", workbook);
55
+ return responseCustomWorkbookData(grnState, queryURL, workbook.name);
89
56
  };
90
57
 
91
- const queryNetworkDatabase = (query) => {
92
- let queryURL = buildNetworkURL(query.type, query.info);
93
- return responseNetworkData("", queryURL);
94
- };
58
+ const constructFullUrl = (queryURL) =>
59
+ [$(".service-root").val(), queryURL].join("/");
95
60
 
96
- // Upload Custom Workbook Functions
97
- const buildCustomWorkbookURL = (name, genes, links) => {
98
- let baseQuery = `upload-custom-workbook?name=${name}`;
99
- let genesString = "";
100
- let linksString = "";
101
- let genesByIndex = {};
102
- let i = 0;
103
- for (let gene in genes) {
104
- genesString += `${genes[gene]},`;
105
- genesByIndex[gene] = i;
106
- i++;
107
- }
108
- for (let regulator in links) {
109
- for (let target of links[regulator]) {
110
- linksString += `${genesByIndex[regulator]}->${genesByIndex[target]},`;
111
- }
112
- }
113
- baseQuery += `&genes=${genesString.substring(0, genesString.length - 1)}`;
114
- baseQuery += `&links=${linksString.substring(0, linksString.length - 1)}`;
115
- return baseQuery;
116
- };
61
+ const getWorkbookFromForm = (formData, queryURL) => {
62
+ const fullUrl = constructFullUrl(queryURL);
117
63
 
118
- const uploadCustomWorkbook = (workbook, grnState) => {
119
- let queryURL = buildCustomWorkbookURL(workbook.name, workbook.genes, workbook.links);
120
- return responseCustomWorkbookData(grnState, queryURL, workbook.name);
64
+ // The presence of formData is taken to indicate a POST.
65
+ return formData
66
+ ? $.ajax({
67
+ url: fullUrl,
68
+ data: formData,
69
+ processData: false,
70
+ contentType: false,
71
+ type: "POST",
72
+ crossDomain: true,
73
+ })
74
+ : $.getJSON(fullUrl);
121
75
  };
122
76
 
77
+ const getWorkbookFromUrl = (queryURL) => {
78
+ const fullUrl = constructFullUrl(queryURL);
79
+ return $.getJSON(fullUrl);
80
+ };
123
81
 
124
- export {queryExpressionDatabase, queryNetworkDatabase, uploadCustomWorkbook};
82
+ export {
83
+ queryExpressionDatabase,
84
+ queryNetworkDatabase,
85
+ uploadCustomWorkbook,
86
+ getWorkbookFromForm,
87
+ getWorkbookFromUrl,
88
+ };
@@ -6,7 +6,7 @@ export const GREY_EDGES_DASHED_MENU = "#grey-edges-dashed-menu";
6
6
  export const GREY_EDGES_DASHED_SIDEBAR = "#dashedGrayLineButton";
7
7
 
8
8
  export const CREATE_NETWORK_CLASS = ".create-network";
9
- export const CREATE_NETWORK_MODAL = "#createNetworkModal";
9
+ export const CREATE_NETWORK_MODAL = "#generateNetworkModal";
10
10
 
11
11
  export const UNWEIGHTED_DEMO_ID = ".unweighted";
12
12
  export const UNWEIGHTED_DEMO_PATH = "demo/unweighted";
@@ -1,15 +1,24 @@
1
+ /* eslint-disable max-len */
1
2
  import {CREATE_NETWORK_CLASS, CREATE_NETWORK_MODAL} from "./constants";
2
3
  import { queryNetworkDatabase, uploadCustomWorkbook } from "./api/grnsight-api";
3
4
  import { grnState } from "./grnstate";
4
5
 
5
- export const createNetwork = function () {
6
+ export const generateNetwork = function () {
7
+ const GENE_EXCEPTIONS = {
8
+ "DUR1,2" : "DUR12",
9
+ "IMP2'" : "IMP21",
10
+ "ARG5,6" : "ARG56",
11
+ "ADE5,7" : "ADE57",
12
+ "MF(ALPHA)1" : "YPL187W",
13
+ "MF(ALPHA)2" : "YGL089C"
14
+ };
6
15
  const createHTMLforForm = (sources) => {
7
16
  let result = `
8
- <div id=\'createNetworkFormContainer\' '>
9
- <h2 id=\'createNetwork\'>Create Network</h2>
10
- <div class=\'form-group\'>
11
- <label for=\'network-source\' id=\'network-source-label\'>Network Source</label>
12
- <select class=\'network-dropdown btn btn-default\' id=\'network-source\'>
17
+ <div id=\'generateNetworkFormContainer\' '>
18
+ <h2 id=\'generateNetwork\'>Generate Network</h2>
19
+ <div class=\'form-group\'>
20
+ <label for=\'network-source\' id=\'network-source-label\'>Network Source</label>
21
+ <select class=\'network-dropdown btn btn-default\' id=\'network-source\'>
13
22
  `;
14
23
  if (sources.length !== 1) {
15
24
  result += "<option value=\'none\' selected=\'true\' disabled>Select Network Source</option>";
@@ -24,10 +33,10 @@ export const createNetwork = function () {
24
33
  `;
25
34
  }
26
35
  result += `</select>
27
- <p>Warning: changing network source will remove all current genes in network</p>
36
+ <p>Warning: changing network source will clear the list of genes below.</p>
28
37
  </div>
29
38
  <div class=\'form-group\' id=\'getNetworkGenesForm\'>
30
- <form id=\'getNetworkGenesForm\'>
39
+ <form id=\'getNetworkGenesForm\' class=\'NetworkGenesForm\' >
31
40
  <label for=\'network-search-bar\' id=\'network-source-label\'>Select genes</label>
32
41
  <input type=\'text\' id=\'network-search-bar\' name=\'network-search-bar\'></input>
33
42
  <button id=\'enter-search\' type=\'submit\' class=\'search-button btn btn-default\'>
@@ -37,10 +46,7 @@ export const createNetwork = function () {
37
46
  </div>
38
47
  <div id=\'selected-genes-container\'>
39
48
  <div id=\'selected-genes\'>
40
- <p>Added genes go here! Click on a gene to remove it</p>
41
- </div>
42
- </div>
43
- <button id=\'submit-network\' class=\'btn btn-default\'>Create Network</input>
49
+ <p>Added genes go here! Click on a gene to remove it.</p>
44
50
  </div>
45
51
  `;
46
52
  return result;
@@ -78,28 +84,38 @@ export const createNetwork = function () {
78
84
  }
79
85
  };
80
86
 
87
+ const validGene = function (gene) {
88
+ if (/^[A-Z0-9_-]{1,12}$/.test(gene)) {
89
+ return gene;
90
+ }
91
+ if (Object.keys(GENE_EXCEPTIONS).includes(gene)) {
92
+ return GENE_EXCEPTIONS[gene];
93
+ }
94
+ return "";
95
+ };
81
96
  const addGene = function () {
82
- let gene = `${$("#network-search-bar").val()}`.toUpperCase();
97
+ const searchGene = `${$("#network-search-bar").val()}`.toUpperCase();
83
98
  $("#network-search-bar").val("");
84
- if (!(/^[A-Z0-9_-]{1,12}$/.test(gene))) {
85
- alert(`Gene: ${gene} is not to GRNsight specifications. Genes must be 12 characters or less,
99
+ const gene = validGene(searchGene);
100
+ if (gene === "") {
101
+ alert(`Gene: ${searchGene} is not to GRNsight specifications. Genes must be 12 characters or less,
86
102
  containing "-", "_", and alpha-numeric characters only`);
87
103
  } else {
88
104
  let source = grnState.customWorkbook.source;
89
105
  let headers = {
90
106
  type:"NetworkGeneFromSource",
91
- info: {
92
- gene: gene,
93
- source:grnState.customWorkbook.sources[source].source,
94
- timestamp:grnState.customWorkbook.sources[source].timestamp.substring(0, 19).replace("T", " ")
95
- }
107
+ gene: gene,
108
+ source:grnState.customWorkbook.sources[source].source,
109
+ timestamp:grnState.customWorkbook.sources[source].timestamp
96
110
  };
97
111
  queryNetworkDatabase(headers).then(function (response) {
98
112
  if (response.geneId !== null && response.displayGeneId !== null) {
99
113
  grnState.customWorkbook.genes[response.geneId] = response.displayGeneId;
100
114
  displayCurrentGenes();
101
115
  } else {
102
- alert(`Gene: ${gene} was not found in this database. Please check for any typos and try again.`);
116
+ alert(
117
+ `Gene: ${searchGene} was not found in this database. Please check for any typos and try again.`
118
+ );
103
119
  }
104
120
  }).catch(function (error) {
105
121
  console.log(error.stack);
@@ -110,17 +126,31 @@ containing "-", "_", and alpha-numeric characters only`);
110
126
  }
111
127
  };
112
128
 
113
- const displayCreateNetworkModal = function () {
114
- $("#createNetworkFormContainer").remove();
129
+ const createHTMLforModalButtons = () => {
130
+ return `
131
+ <div id=\'generateNetworkFooter\' class=\'modal-footer-div\'>
132
+ <div>
133
+ <input type=\'button\' class=\'btn btn-default\' id=\'submit-network\' value=\'Generate Network\'/>
134
+ <input type=\'button\' class=\'btn btn-default\' data-dismiss=\'modal\' value=\'Cancel\' />
135
+ </div>
136
+ </div>
137
+ `;
138
+ };
139
+
140
+ const displayGenerateNetworkModal = function () {
141
+ $("#generateNetworkFormContainer").remove();
142
+ $("#generateNetworkFooter").remove();
143
+ $("#generateNetworkFooter-container").append(createHTMLforModalButtons());
115
144
  grnState.customWorkbook = {
116
145
  genes : {},
117
- source : null
146
+ source : null,
147
+ sources : null
118
148
  };
119
149
  // get sources from database
120
- queryNetworkDatabase({type:"NetworkSource", info:null}).then(function (response) {
121
- $("#createNetworkQuestions-container").append(createHTMLforForm(Object.keys(response.sources)));
150
+ queryNetworkDatabase({type:"NetworkSource"}).then(function (response) {
151
+ $("#generateNetworkQuestions-container").append(createHTMLforForm(Object.keys(response.sources)));
122
152
  grnState.customWorkbook.sources = response.sources;
123
- grnState.customWorkbook.source = Object.keys(response.sources).length === 1 ?
153
+ grnState.customWorkbook.source = Object.keys(response.sources).length >= 1 ?
124
154
  Object.keys(response.sources)[0] : null;
125
155
  }).catch(function (error) {
126
156
  console.log(error.stack);
@@ -133,7 +163,7 @@ containing "-", "_", and alpha-numeric characters only`);
133
163
  $("body").on("click", CREATE_NETWORK_CLASS, function (event) {
134
164
  event.preventDefault();
135
165
  event.stopPropagation();
136
- displayCreateNetworkModal();
166
+ displayGenerateNetworkModal();
137
167
  });
138
168
 
139
169
  $("body").on("change", "#network-source", function (event) {
@@ -150,28 +180,25 @@ containing "-", "_", and alpha-numeric characters only`);
150
180
  alert(`GRNsight is only capable of handling 75 genes at most. Your proposed network contains
151
181
  ${genesAmount} genes. Please remove some genes from your proposed network.`);
152
182
  } else {
153
-
154
- let source = grnState.customWorkbook.source;
155
- let headers = {
156
- type:"CreateNetwork",
157
- info: {
158
- genes: grnState.customWorkbook.genes,
159
- source:grnState.customWorkbook.sources[source].source,
160
- timestamp:grnState.customWorkbook.sources[source].timestamp.substring(0, 19).replace("T", " ")
161
- }
183
+ const genes = Object.keys(grnState.customWorkbook.genes).map(g => grnState.customWorkbook.genes[g]);
184
+ const source = grnState.customWorkbook.source;
185
+ const headers = {
186
+ type:"GenerateNetwork",
187
+ genes: genes.join(","),
188
+ source:grnState.customWorkbook.sources[source].source,
189
+ timestamp:grnState.customWorkbook.sources[source].timestamp
162
190
  };
163
191
  queryNetworkDatabase(headers).then(function (response) {
164
192
  grnState.customWorkbook.links = response.links;
165
- let genes = grnState.customWorkbook.genes;
166
- let links = grnState.customWorkbook.links;
167
- let genesAmount = Object.keys(genes).length;
168
- let edgesAmount = Object.keys(links).length;
193
+ const links = Object.entries(grnState.customWorkbook.links);
194
+ const genesAmount = genes.length;
195
+ const edgesAmount = links.flatMap( (entry) => entry[1].map((target) => [entry[0], target])).length;
169
196
  if (edgesAmount > 100) {
170
197
  alert(`GRNsight is only capable of handling 100 edges at most. Your proposed network contains
171
198
  ${edgesAmount} regulatory connections. Please remove some genes from your proposed network.`);
172
199
  } else {
173
- let name = `Custom Workbook: UnweightedGRN(${genesAmount} genes, ${edgesAmount} edges)`;
174
- let workbook = {name, genes, links};
200
+ const name = `Custom Workbook: UnweightedGRN(${genesAmount} genes, ${edgesAmount} edges)`;
201
+ const workbook = {name, genes, links : links.map( l => `${l[0]}->${l[1]}`).join(",")};
175
202
  uploadCustomWorkbook(workbook, grnState);
176
203
  $(CREATE_NETWORK_MODAL).modal("hide");
177
204
  }
@@ -1,6 +1,6 @@
1
1
  import { displayStatistics } from "./graph-statistics"; // eslint-disable-line no-unused-vars
2
2
  import { upload } from "./upload";
3
- import { createNetwork } from "./createNetwork";
3
+ import { generateNetwork } from "./generateNetwork";
4
4
 
5
5
  import { grnState } from "./grnstate";
6
6
  import { updateApp } from "./update-app";
@@ -10,4 +10,4 @@ setupHandlers(grnState);
10
10
  updateApp(grnState);
11
11
 
12
12
  upload();
13
- createNetwork();
13
+ generateNetwork();