ezmedicationinput 0.1.43 → 0.1.45

package/dist/maps.js

@@ -1,1680 +0,0 @@
-"use strict";
-Object.defineProperty(exports, "__esModule", { value: true });
-exports.DEFAULT_ADDITIONAL_INSTRUCTION_DEFINITIONS = exports.DEFAULT_ADDITIONAL_INSTRUCTION_ENTRIES = exports.DEFAULT_PRN_REASON_DEFINITIONS = exports.DEFAULT_PRN_REASON_ENTRIES = exports.DEFAULT_UNIT_BY_ROUTE = exports.DEFAULT_UNIT_BY_NORMALIZED_FORM = exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE = exports.KNOWN_DOSAGE_FORMS_TO_DOSE = exports.WORD_FREQUENCIES = exports.DAY_OF_WEEK_TOKENS = exports.DISCOURAGED_TOKENS = exports.MEAL_KEYWORDS = exports.EVENT_TIMING_TOKENS = exports.TIMING_ABBREVIATIONS = exports.DEFAULT_UNIT_SYNONYMS = exports.HOUSEHOLD_VOLUME_UNITS = exports.DEFAULT_BODY_SITE_SNOMED = exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = exports.DEFAULT_ROUTE_SYNONYMS = exports.ROUTE_BY_SNOMED = exports.ROUTE_TEXT = exports.ROUTE_SNOMED = void 0;
-exports.normalizeBodySiteKey = normalizeBodySiteKey;
-exports.normalizePrnReasonKey = normalizePrnReasonKey;
-exports.normalizeAdditionalInstructionKey = normalizeAdditionalInstructionKey;
-exports.findPrnReasonDefinitionByCoding = findPrnReasonDefinitionByCoding;
-exports.findAdditionalInstructionDefinitionByCoding = findAdditionalInstructionDefinitionByCoding;
-const types_1 = require("./types");
-const object_1 = require("./utils/object");
-const SNOMED_SYSTEM = "http://snomed.info/sct";
-const ROUTE_TEXT_OVERRIDES = {
-    [types_1.RouteCode["Oral route"]]: "by mouth",
-    [types_1.RouteCode["Sublingual route"]]: "sublingual",
-    [types_1.RouteCode["Buccal route"]]: "buccal",
-    [types_1.RouteCode["Respiratory tract route (qualifier value)"]]: "inhalation",
-    [types_1.RouteCode["Nasal route"]]: "intranasal",
-    [types_1.RouteCode["Topical route"]]: "topical",
-    [types_1.RouteCode["Transdermal route"]]: "transdermal",
-    [types_1.RouteCode["Subcutaneous route"]]: "subcutaneous",
-    [types_1.RouteCode["Intramuscular route"]]: "intramuscular",
-    [types_1.RouteCode["Intravenous route"]]: "intravenous",
-    [types_1.RouteCode["Per rectum"]]: "rectal",
-    [types_1.RouteCode["Per vagina"]]: "vaginal",
-    [types_1.RouteCode["Ophthalmic route"]]: "ophthalmic",
-    [types_1.RouteCode["Intravitreal route (qualifier value)"]]: "intravitreal"
-};
-function defaultRouteText(display) {
-    const cleaned = display.replace(/\s*\(qualifier value\)/gi, "");
-    const withoutSuffix = cleaned.replace(/\b(route|use)\b/gi, "");
-    return withoutSuffix.replace(/\s+/g, " ").trim().toLowerCase();
-}
-const ROUTE_SNOMED_ENTRIES = (0, object_1.objectEntries)(types_1.SNOMEDCTRouteCodes).map(([display, code]) => {
-    const routeCode = code;
-    return [
-        routeCode,
-        { code: code, display }
-    ];
-});
-/**
- * SNOMED CT codings aligned with every known RouteCode. Keeping the structure
- * data-driven ensures any additions to the enumeration are surfaced
- * automatically throughout the library.
- */
-exports.ROUTE_SNOMED = (0, object_1.objectFromEntries)(ROUTE_SNOMED_ENTRIES);
-exports.ROUTE_TEXT = (0, object_1.objectFromEntries)(ROUTE_SNOMED_ENTRIES.map(([routeCode, meta]) => {
-    var _a;
-    return [
-        routeCode,
-        (_a = ROUTE_TEXT_OVERRIDES[routeCode]) !== null && _a !== void 0 ? _a : defaultRouteText(meta.display)
-    ];
-}));
-/**
- * Inverse lookup so that SNOMED codes flowing in from FHIR can be mapped back
- * into our internal RouteCode abstraction during round-tripping.
- */
-exports.ROUTE_BY_SNOMED = (0, object_1.objectFromEntries)(ROUTE_SNOMED_ENTRIES.map(([routeCode, meta]) => [meta.code, routeCode]));
-exports.DEFAULT_ROUTE_SYNONYMS = (() => {
-    const map = {};
-    const assign = (key, code) => {
-        if (!key)
-            return;
-        const normalized = key.trim().toLowerCase();
-        if (!normalized || map[normalized]) {
-            return;
-        }
-        map[normalized] = { code, text: exports.ROUTE_TEXT[code] };
-    };
-    const assignWithAdverb = (key, code) => {
-        assign(key, code);
-        if (!key)
-            return;
-        const normalized = key.trim().toLowerCase();
-        if (!normalized) {
-            return;
-        }
-        if (!/^[a-z]+$/.test(normalized)) {
-            return;
-        }
-        if (normalized.length < 4 || normalized.endsWith("ly") || normalized.endsWith("eal")) {
-            return;
-        }
-        let adverb;
-        if (normalized.endsWith("ic")) {
-            adverb = normalized.replace(/ic$/, "ically");
-        }
-        else {
-            adverb = `${normalized}ly`;
-        }
-        assign(adverb, code);
-    };
-    const registerVariants = (value, code) => {
-        if (!value)
-            return;
-        assignWithAdverb(value, code);
-        const withoutParens = value
-            .replace(/[()]/g, " ")
-            .replace(/\s+/g, " ")
-            .trim();
-        assignWithAdverb(withoutParens, code);
-        const withoutCommas = value
-            .replace(/,/g, " ")
-            .replace(/\s+/g, " ")
-            .trim();
-        assignWithAdverb(withoutCommas, code);
-        const withoutPunctuation = value
-            .replace(/[().,-]/g, " ")
-            .replace(/\s+/g, " ")
-            .trim();
-        assignWithAdverb(withoutPunctuation, code);
-    };
-    registerVariants("po", types_1.RouteCode["Oral route"]);
-    registerVariants("oral", types_1.RouteCode["Oral route"]);
-    registerVariants("by mouth", types_1.RouteCode["Oral route"]);
-    registerVariants("per os", types_1.RouteCode["Oral route"]);
-    registerVariants("sl", types_1.RouteCode["Sublingual route"]);
-    registerVariants("s.l.", types_1.RouteCode["Sublingual route"]);
-    registerVariants("sublingual", types_1.RouteCode["Sublingual route"]);
-    registerVariants("buccal", types_1.RouteCode["Buccal route"]);
-    registerVariants("inh", types_1.RouteCode["Respiratory tract route (qualifier value)"]);
-    registerVariants("inhalation", types_1.RouteCode["Respiratory tract route (qualifier value)"]);
-    registerVariants("inhaled", types_1.RouteCode["Respiratory tract route (qualifier value)"]);
-    registerVariants("iv", types_1.RouteCode["Intravenous route"]);
-    registerVariants("ivp", types_1.RouteCode["Intravenous route"]);
-    registerVariants("ivpb", types_1.RouteCode["Intravenous route"]);
-    registerVariants("iv push", types_1.RouteCode["Intravenous route"]);
-    registerVariants("iv bolus", types_1.RouteCode["Intravenous route"]);
-    registerVariants("iv drip", types_1.RouteCode["Intravenous route"]);
-    registerVariants("intravenous", types_1.RouteCode["Intravenous route"]);
-    registerVariants("im", types_1.RouteCode["Intramuscular route"]);
-    registerVariants("im injection", types_1.RouteCode["Intramuscular route"]);
-    registerVariants("intramuscular", types_1.RouteCode["Intramuscular route"]);
-    registerVariants("sc", types_1.RouteCode["Subcutaneous route"]);
-    registerVariants("sq", types_1.RouteCode["Subcutaneous route"]);
-    registerVariants("subq", types_1.RouteCode["Subcutaneous route"]);
-    registerVariants("subcut", types_1.RouteCode["Subcutaneous route"]);
-    registerVariants("subcutaneous", types_1.RouteCode["Subcutaneous route"]);
-    registerVariants("in", types_1.RouteCode["Nasal route"]);
-    registerVariants("intranasal", types_1.RouteCode["Nasal route"]);
-    registerVariants("nasal", types_1.RouteCode["Nasal route"]);
-    registerVariants("top", types_1.RouteCode["Topical route"]);
-    registerVariants("topical", types_1.RouteCode["Topical route"]);
-    registerVariants("td", types_1.RouteCode["Transdermal route"]);
-    registerVariants("patch", types_1.RouteCode["Transdermal route"]);
-    registerVariants("transdermal", types_1.RouteCode["Transdermal route"]);
-    registerVariants("pr", types_1.RouteCode["Per rectum"]);
-    registerVariants("rectal", types_1.RouteCode["Per rectum"]);
-    registerVariants("supp", types_1.RouteCode["Per rectum"]);
-    registerVariants("suppo", types_1.RouteCode["Per rectum"]);
-    registerVariants("suppository", types_1.RouteCode["Per rectum"]);
-    registerVariants("suppositories", types_1.RouteCode["Per rectum"]);
-    registerVariants("pv", types_1.RouteCode["Per vagina"]);
-    registerVariants("vaginal", types_1.RouteCode["Per vagina"]);
-    registerVariants("oph", types_1.RouteCode["Ophthalmic route"]);
-    registerVariants("ophth", types_1.RouteCode["Ophthalmic route"]);
-    registerVariants("ophthalmic", types_1.RouteCode["Ophthalmic route"]);
-    registerVariants("ocular", types_1.RouteCode["Ophthalmic route"]);
-    registerVariants("intravitreal", types_1.RouteCode["Intravitreal route (qualifier value)"]);
-    registerVariants("intravitreal injection", types_1.RouteCode["Intravitreal route (qualifier value)"]);
-    registerVariants("ivt", types_1.RouteCode["Intravitreal route (qualifier value)"]);
-    for (const [routeCode, meta] of ROUTE_SNOMED_ENTRIES) {
-        const display = meta.display.toLowerCase();
-        registerVariants(display, routeCode);
-        const withoutQualifier = display.replace(/\s*\(qualifier value\)/g, "").trim();
-        registerVariants(withoutQualifier, routeCode);
-        const withoutSuffix = withoutQualifier
-            .replace(/\b(route|use)\b/g, "")
-            .replace(/\s+/g, " ")
-            .trim();
-        registerVariants(withoutSuffix, routeCode);
-        const withoutPer = withoutSuffix.replace(/^per\s+/, "").trim();
-        registerVariants(withoutPer, routeCode);
-    }
-    return map;
-})();
-/**
- * Normalizes body-site phrases into lookup keys by trimming, lower-casing, and
- * collapsing whitespace. Custom site maps should normalize their keys with the
- * same logic to ensure consistent lookups.
- */
-function normalizeBodySiteKey(value) {
-    return value
-        .trim()
-        .toLowerCase()
-        .replace(/[^\p{L}\p{N}]+/gu, " ")
-        .replace(/\s+/g, " ")
-        .trim();
-}
-exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = [
-    {
-        names: ["eye", "eyes"],
-        definition: { coding: { code: "81745001", display: "Eye" } }
-    },
-    {
-        names: ["left eye"],
-        definition: {
-            coding: { code: "1290031003", display: "Structure of left eye proper" }
-        }
-    },
-    {
-        names: ["right eye"],
-        definition: {
-            coding: { code: "1290032005", display: "Structure of right eye proper" }
-        }
-    },
-    {
-        names: ["both eyes", "bilateral eyes"],
-        definition: { coding: { code: "40638003", display: "Structure of both eyes" } }
-    },
-    {
-        names: ["ear", "ears"],
-        definition: { coding: { code: "117590005", display: "Ear-related structure" } }
-    },
-    {
-        names: ["left ear"],
-        definition: { coding: { code: "89644007", display: "Left ear" } }
-    },
-    {
-        names: ["right ear"],
-        definition: { coding: { code: "25577004", display: "Right ear" } }
-    },
-    {
-        names: ["both ears", "bilateral ears"],
-        definition: { coding: { code: "34338003", display: "Both ears" } }
-    },
-    {
-        names: ["nostril", "nostrils"],
-        definition: { coding: { code: "1797002", display: "Naris" } }
-    },
-    {
-        names: ["left nostril", "left naris"],
-        definition: {
-            coding: { code: "723608007", display: "Structure of left anterior naris" }
-        }
-    },
-    {
-        names: ["right nostril", "right naris"],
-        definition: {
-            coding: { code: "723609004", display: "Structure of right anterior naris" }
-        }
-    },
-    {
-        names: ["nares", "anterior nares"],
-        definition: { coding: { code: "244506005", display: "Anterior nares" } }
-    },
-    {
-        names: ["nose"],
-        definition: { coding: { code: "181195007", display: "Entire nose" } }
-    },
-    {
-        names: ["mouth"],
-        definition: { coding: { code: "123851003", display: "Mouth region" } }
-    },
-    {
-        names: ["tongue", "tongues"],
-        definition: { coding: { code: "21974007", display: "Tongue" } }
-    },
-    {
-        names: ["cheek", "cheeks"],
-        definition: {
-            coding: { code: "60819002", display: "Buccal region of face" }
-        }
-    },
-    {
-        names: ["gum", "gums"],
-        definition: {
-            coding: {
-                code: "362116001",
-                display: "Entire gum and supporting structure of tooth"
-            }
-        }
-    },
-    {
-        names: ["tooth"],
-        definition: { coding: { code: "38199008", display: "Tooth" } }
-    },
-    {
-        names: ["teeth"],
-        definition: { coding: { code: "1162715001", display: "All teeth" } }
-    },
-    {
-        names: ["arm", "upper arm"],
-        definition: { coding: { code: "302538001", display: "Entire upper arm" } }
-    },
-    {
-        names: ["left arm", "left upper arm"],
-        definition: {
-            coding: { code: "368208006", display: "Left upper arm structure" }
-        }
-    },
-    {
-        names: ["right arm", "right upper arm"],
-        definition: { coding: { code: "368209003", display: "Right upper arm" } }
-    },
-    {
-        names: ["both arms", "bilateral arms"],
-        definition: { coding: { code: "69273007", display: "Both arms" } }
-    },
-    {
-        names: ["forearm"],
-        definition: { coding: { code: "14975008", display: "Forearm" } }
-    },
-    {
-        names: ["left forearm"],
-        definition: { coding: { code: "66480008", display: "Left forearm" } }
-    },
-    {
-        names: ["right forearm"],
-        definition: { coding: { code: "64262003", display: "Right forearm" } }
-    },
-    {
-        names: ["leg", "lower leg"],
-        definition: {
-            coding: { code: "362793004", display: "Entire lower leg, from knee to ankle" }
-        }
-    },
-    {
-        names: ["left leg", "left lower leg"],
-        definition: { coding: { code: "213384005", display: "Entire left lower leg" } }
-    },
-    {
-        names: ["right leg", "right lower leg"],
-        definition: { coding: { code: "213289002", display: "Entire right lower leg" } }
-    },
-    {
-        names: ["both legs", "bilateral legs"],
-        definition: { coding: { code: "40927001", display: "Both legs" } }
-    },
-    {
-        names: ["thigh"],
-        definition: { coding: { code: "68367000", display: "Thigh" } }
-    },
-    {
-        names: ["left thigh"],
-        definition: { coding: { code: "61396006", display: "Left thigh" } }
-    },
-    {
-        names: ["right thigh"],
-        definition: { coding: { code: "11207009", display: "Right thigh" } }
-    },
-    {
-        names: ["hand", "hands"],
-        definition: { coding: { code: "85562004", display: "Hand" } }
-    },
-    {
-        names: ["left hand"],
-        definition: { coding: { code: "85151006", display: "Left hand" } }
-    },
-    {
-        names: ["right hand"],
-        definition: { coding: { code: "78791008", display: "Right hand" } }
-    },
-    {
-        names: ["foot", "feet"],
-        definition: { coding: { code: "56459004", display: "Foot" } }
-    },
-    {
-        names: ["left foot"],
-        definition: { coding: { code: "22335008", display: "Left foot" } }
-    },
-    {
-        names: ["right foot"],
-        definition: { coding: { code: "7769000", display: "Right foot" } }
-    },
-    {
-        names: ["abdomen", "abdominal", "belly"],
-        definition: { coding: { code: "302553009", display: "Entire abdomen" } }
-    },
-    {
-        names: ["back"],
-        definition: { coding: { code: "77568009", display: "Back" } }
-    },
-    {
-        names: ["scalp"],
-        definition: { coding: { code: "41695006", display: "Scalp" } }
-    },
-    {
-        names: ["face"],
-        definition: { coding: { code: "89545001", display: "Face" } }
-    },
-    {
-        names: ["forehead"],
-        definition: { coding: { code: "52795006", display: "Forehead" } }
-    },
-    {
-        names: ["chin"],
-        definition: {
-            coding: {
-                code: "897081006",
-                display: "Skin and/or subcutaneous tissue of chin"
-            }
-        }
-    },
-    {
-        names: ["neck"],
-        definition: { coding: { code: "45048000", display: "Neck" } }
-    },
-    {
-        names: ["buttock", "buttocks", "gluteal", "glute"],
-        definition: { coding: { code: "46862004", display: "Buttock" } }
-    },
-    {
-        names: ["left buttock", "left gluteal"],
-        definition: { coding: { code: "723979003", display: "Structure of left buttock" } }
-    },
-    {
-        names: ["right buttock", "right gluteal"],
-        definition: { coding: { code: "723980000", display: "Structure of right buttock" } }
-    },
-    {
-        names: ["muscle", "muscles"],
-        definition: {
-            coding: {
-                code: "362876008",
-                display: "All skeletal and smooth muscles of the body"
-            }
-        }
-    },
-    {
-        names: ["vein", "veins"],
-        definition: { coding: { code: "181367001", display: "Entire vein" } }
-    },
-    {
-        names: ["vagina", "vaginal"],
-        definition: { coding: { code: "76784001", display: "Vagina" } }
-    },
-    {
-        names: ["penis", "penile"],
-        definition: { coding: { code: "18911002", display: "Penis structure" } }
-    },
-    {
-        names: ["rectum", "rectal"],
-        definition: { coding: { code: "34402009", display: "Rectum" } }
-    },
-    {
-        names: ["anus"],
-        definition: { coding: { code: "181262009", display: "Entire anus" } }
-    },
-    {
-        names: ["perineum"],
-        definition: { coding: { code: "243990009", display: "Entire perineum" } }
-    },
-    {
-        names: ["skin"],
-        definition: { coding: { code: "181469002", display: "Entire skin" } }
-    },
-    {
-        names: ["hair"],
-        definition: {
-            coding: { code: "386045008", display: "Hair structure (body structure)" }
-        }
-    }
-];
-exports.DEFAULT_BODY_SITE_SNOMED = (0, object_1.objectFromEntries)(exports.DEFAULT_BODY_SITE_SNOMED_SOURCE.reduce((entries, source) => {
-    const { names, definition } = source;
-    for (const name of names) {
-        const key = normalizeBodySiteKey(name);
-        if (!key) {
-            continue;
-        }
-        entries.push([key, definition]);
-    }
-    return entries;
-}, []));
-const UNIT_PREFIXES = [
-    { canonical: "", abbreviations: [""], names: [{ singular: "", plural: "" }] },
-    {
-        canonical: "m",
-        abbreviations: ["m"],
-        names: [{ singular: "milli", plural: "milli" }],
-    },
-    {
-        canonical: "mc",
-        abbreviations: ["mc", "µ", "μ", "u"],
-        names: [{ singular: "micro", plural: "micro" }],
-    },
-    {
-        canonical: "n",
-        abbreviations: ["n"],
-        names: [{ singular: "nano", plural: "nano" }],
-    },
-    {
-        canonical: "k",
-        abbreviations: ["k"],
-        names: [{ singular: "kilo", plural: "kilo" }],
-    },
-];
-const METRIC_UNIT_BASES = [
-    {
-        canonical: "g",
-        abbreviations: ["g"],
-        names: [
-            { singular: "gram", plural: "grams" },
-            { singular: "gramme", plural: "grammes" },
-        ],
-    },
-    {
-        canonical: "L",
-        abbreviations: ["l"],
-        names: [
-            { singular: "liter", plural: "liters" },
-            { singular: "litre", plural: "litres" },
-        ],
-    },
-];
-function assignUnitSynonym(map, key, canonical) {
-    const normalized = key.trim().toLowerCase();
-    if (!normalized || map[normalized]) {
-        return;
-    }
-    map[normalized] = canonical;
-}
-function addMetricUnitSynonyms(map) {
-    for (const prefix of UNIT_PREFIXES) {
-        for (const base of METRIC_UNIT_BASES) {
-            const canonical = `${prefix.canonical}${base.canonical}`;
-            for (const prefixAbbrev of prefix.abbreviations) {
-                for (const baseAbbrev of base.abbreviations) {
-                    if (!baseAbbrev) {
-                        continue;
-                    }
-                    const token = `${prefixAbbrev}${baseAbbrev}`;
-                    assignUnitSynonym(map, token, canonical);
-                    assignUnitSynonym(map, `${token}s`, canonical);
-                    if (token.endsWith(".")) {
-                        assignUnitSynonym(map, token.replace(/\.+$/, ""), canonical);
-                    }
-                }
-            }
-            for (const prefixName of prefix.names) {
-                for (const baseName of base.names) {
-                    const singular = `${prefixName.singular}${baseName.singular}`;
-                    const plural = `${prefixName.singular}${baseName.plural}`;
-                    const hyphenSingular = prefixName.singular
-                        ? `${prefixName.singular}-${baseName.singular}`
-                        : baseName.singular;
-                    const hyphenPlural = prefixName.singular
-                        ? `${prefixName.singular}-${baseName.plural}`
-                        : baseName.plural;
-                    assignUnitSynonym(map, singular, canonical);
-                    assignUnitSynonym(map, plural, canonical);
-                    assignUnitSynonym(map, hyphenSingular, canonical);
-                    assignUnitSynonym(map, hyphenPlural, canonical);
-                }
-            }
-        }
-    }
-}
-exports.HOUSEHOLD_VOLUME_UNITS = ["tsp", "tbsp"];
-const STATIC_UNIT_SYNONYMS = {
-    u: "U",
-    unit: "U",
-    units: "U",
-    iu: "IU",
-    "i.u": "IU",
-    "i.u.": "IU",
-    ius: "IU",
-    tab: "tab",
-    tabs: "tab",
-    tablet: "tab",
-    tablets: "tab",
-    cap: "cap",
-    caps: "cap",
-    capsule: "cap",
-    capsules: "cap",
-    puff: "puff",
-    puffs: "puff",
-    spray: "spray",
-    sprays: "spray",
-    drop: "drop",
-    drops: "drop",
-    patch: "patch",
-    patches: "patch",
-    supp: "suppository",
-    suppository: "suppository",
-    suppositories: "suppository",
-    tsp: "tsp",
-    "tsp.": "tsp",
-    tsps: "tsp",
-    "tsps.": "tsp",
-    teaspoon: "tsp",
-    teaspoons: "tsp",
-    tbsp: "tbsp",
-    "tbsp.": "tbsp",
-    tbs: "tbsp",
-    "tbs.": "tbsp",
-    tablespoon: "tbsp",
-    tablespoons: "tbsp",
-};
-exports.DEFAULT_UNIT_SYNONYMS = (() => {
-    const map = Object.assign({}, STATIC_UNIT_SYNONYMS);
-    addMetricUnitSynonyms(map);
-    return map;
-})();
-exports.TIMING_ABBREVIATIONS = {
-    qd: {
-        code: "QD",
-        frequency: 1,
-        period: 1,
-        periodUnit: types_1.FhirPeriodUnit.Day,
-        discouraged: "QD"
-    },
-    qod: {
-        code: "QOD",
-        period: 2,
-        periodUnit: types_1.FhirPeriodUnit.Day,
-        discouraged: "QOD"
-    },
-    od: {
-        code: "QD",
-        frequency: 1,
-        period: 1,
-        periodUnit: types_1.FhirPeriodUnit.Day
-    },
-    ad: {
-        period: 2,
-        periodUnit: types_1.FhirPeriodUnit.Day,
-        discouraged: "AD"
-    },
-    bid: {
-        code: "BID",
-        frequency: 2,
-        period: 1,
-        periodUnit: types_1.FhirPeriodUnit.Day
-    },
-    tid: {
-        code: "TID",
-        frequency: 3,
-        period: 1,
-        periodUnit: types_1.FhirPeriodUnit.Day
-    },
-    qid: {
-        code: "QID",
-        frequency: 4,
-        period: 1,
-        periodUnit: types_1.FhirPeriodUnit.Day
-    },
-    q1h: { code: "Q1H", period: 1, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q2h: { code: "Q2H", period: 2, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q3h: { code: "Q3H", period: 3, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q4h: { code: "Q4H", period: 4, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q6h: { code: "Q6H", period: 6, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q8h: { code: "Q8H", period: 8, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q12h: { code: "Q12H", period: 12, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q24h: { code: "Q24H", period: 24, periodUnit: types_1.FhirPeriodUnit.Hour },
-    q1d: {
-        code: "QD",
-        frequency: 1,
-        period: 1,
-        periodUnit: types_1.FhirPeriodUnit.Day
-    },
-    q2d: { code: "Q2D", period: 2, periodUnit: types_1.FhirPeriodUnit.Day },
-    q3d: { code: "Q3D", period: 3, periodUnit: types_1.FhirPeriodUnit.Day },
-    q1wk: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
-    q1w: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
-    q2wk: { code: "Q2WK", period: 2, periodUnit: types_1.FhirPeriodUnit.Week },
-    q1mo: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
-    q2mo: { code: "Q2MO", period: 2, periodUnit: types_1.FhirPeriodUnit.Month },
-    wk: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
-    weekly: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
-    mo: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
-    monthly: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
-    am: { code: "AM", when: [types_1.EventTiming.Morning] },
-    pm: { code: "PM", when: [types_1.EventTiming.Evening] }
-};
-exports.EVENT_TIMING_TOKENS = {
-    ac: types_1.EventTiming["Before Meal"],
-    acm: types_1.EventTiming["Before Breakfast"],
-    acl: types_1.EventTiming["Before Lunch"],
-    acd: types_1.EventTiming["Before Lunch"],
-    acv: types_1.EventTiming["Before Dinner"],
-    pc: types_1.EventTiming["After Meal"],
-    pcm: types_1.EventTiming["After Breakfast"],
-    pcl: types_1.EventTiming["After Lunch"],
-    pcd: types_1.EventTiming["After Lunch"],
-    pcv: types_1.EventTiming["After Dinner"],
-    wm: types_1.EventTiming.Meal,
-    c: types_1.EventTiming.Meal,
-    "with meals": types_1.EventTiming.Meal,
-    "with meal": types_1.EventTiming.Meal,
-    "with food": types_1.EventTiming.Meal,
-    cc: types_1.EventTiming.Meal,
-    "@m": types_1.EventTiming.Meal,
-    "@meal": types_1.EventTiming.Meal,
-    "@meals": types_1.EventTiming.Meal,
-    cm: types_1.EventTiming.Breakfast,
-    breakfast: types_1.EventTiming.Breakfast,
-    bfast: types_1.EventTiming.Breakfast,
-    brkfst: types_1.EventTiming.Breakfast,
-    meal: types_1.EventTiming.Meal,
-    meals: types_1.EventTiming.Meal,
-    food: types_1.EventTiming.Meal,
-    brk: types_1.EventTiming.Breakfast,
-    cd: types_1.EventTiming.Lunch,
-    lunch: types_1.EventTiming.Lunch,
-    lunchtime: types_1.EventTiming.Lunch,
-    cv: types_1.EventTiming.Dinner,
-    dinner: types_1.EventTiming.Dinner,
-    dinnertime: types_1.EventTiming.Dinner,
-    supper: types_1.EventTiming.Dinner,
-    suppertime: types_1.EventTiming.Dinner,
-    am: types_1.EventTiming.Morning,
-    morning: types_1.EventTiming.Morning,
-    morn: types_1.EventTiming.Morning,
-    noon: types_1.EventTiming.Noon,
-    midday: types_1.EventTiming.Noon,
-    "mid-day": types_1.EventTiming.Noon,
-    afternoon: types_1.EventTiming.Afternoon,
-    aft: types_1.EventTiming.Afternoon,
-    pm: types_1.EventTiming.Evening,
-    evening: types_1.EventTiming.Evening,
-    night: types_1.EventTiming.Night,
-    hs: types_1.EventTiming["Before Sleep"],
-    bedtime: types_1.EventTiming["Before Sleep"],
-    bed: types_1.EventTiming["Before Sleep"],
-    sleep: types_1.EventTiming["Before Sleep"],
-    wake: types_1.EventTiming.Wake,
-    waking: types_1.EventTiming.Wake,
-    stat: types_1.EventTiming.Immediate
-};
-const MEAL_KEYWORD_ENTRIES = [];
-function registerMealKeywords(keys, meal) {
-    for (const key of keys) {
-        MEAL_KEYWORD_ENTRIES.push([key, meal]);
-    }
-}
-registerMealKeywords(["breakfast", "bfast", "brkfst", "brk"], {
-    pc: types_1.EventTiming["After Breakfast"],
-    ac: types_1.EventTiming["Before Breakfast"]
-});
-registerMealKeywords(["lunch", "lunchtime"], {
-    pc: types_1.EventTiming["After Lunch"],
-    ac: types_1.EventTiming["Before Lunch"]
-});
-registerMealKeywords(["dinner", "dinnertime", "supper", "suppertime"], {
-    pc: types_1.EventTiming["After Dinner"],
-    ac: types_1.EventTiming["Before Dinner"]
-});
-registerMealKeywords(["meal", "meals", "food"], {
-    pc: types_1.EventTiming["After Meal"],
-    ac: types_1.EventTiming["Before Meal"]
-});
-exports.MEAL_KEYWORDS = (0, object_1.objectFromEntries)(MEAL_KEYWORD_ENTRIES);
-exports.DISCOURAGED_TOKENS = {
-    qd: "QD",
-    qod: "QOD",
-    od: "OD",
-    bld: "BLD",
-    "b-l-d": "BLD",
-    ad: "AD"
-};
-exports.DAY_OF_WEEK_TOKENS = {
-    monday: types_1.FhirDayOfWeek.Monday,
-    mon: types_1.FhirDayOfWeek.Monday,
-    mond: types_1.FhirDayOfWeek.Monday,
-    tuesday: types_1.FhirDayOfWeek.Tuesday,
-    tue: types_1.FhirDayOfWeek.Tuesday,
-    tues: types_1.FhirDayOfWeek.Tuesday,
-    wednesday: types_1.FhirDayOfWeek.Wednesday,
-    wed: types_1.FhirDayOfWeek.Wednesday,
-    weds: types_1.FhirDayOfWeek.Wednesday,
-    thursday: types_1.FhirDayOfWeek.Thursday,
-    thu: types_1.FhirDayOfWeek.Thursday,
-    thur: types_1.FhirDayOfWeek.Thursday,
-    thurs: types_1.FhirDayOfWeek.Thursday,
-    friday: types_1.FhirDayOfWeek.Friday,
-    fri: types_1.FhirDayOfWeek.Friday,
-    saturday: types_1.FhirDayOfWeek.Saturday,
-    sat: types_1.FhirDayOfWeek.Saturday,
-    sunday: types_1.FhirDayOfWeek.Sunday,
-    sun: types_1.FhirDayOfWeek.Sunday,
-    จ: types_1.FhirDayOfWeek.Monday,
-    จัน: types_1.FhirDayOfWeek.Monday,
-    จันทร์: types_1.FhirDayOfWeek.Monday,
-    อ: types_1.FhirDayOfWeek.Tuesday,
-    อัง: types_1.FhirDayOfWeek.Tuesday,
-    อังคาร: types_1.FhirDayOfWeek.Tuesday,
-    พ: types_1.FhirDayOfWeek.Wednesday,
-    พุธ: types_1.FhirDayOfWeek.Wednesday,
-    พฤ: types_1.FhirDayOfWeek.Thursday,
-    พฤหัส: types_1.FhirDayOfWeek.Thursday,
-    พฤหัสบดี: types_1.FhirDayOfWeek.Thursday,
-    ศ: types_1.FhirDayOfWeek.Friday,
-    ศุก: types_1.FhirDayOfWeek.Friday,
-    ศุกร์: types_1.FhirDayOfWeek.Friday,
-    ส: types_1.FhirDayOfWeek.Saturday,
-    เสา: types_1.FhirDayOfWeek.Saturday,
-    เสาร์: types_1.FhirDayOfWeek.Saturday,
-    อา: types_1.FhirDayOfWeek.Sunday,
-    อาท: types_1.FhirDayOfWeek.Sunday,
-    อาทิตย์: types_1.FhirDayOfWeek.Sunday
-};
-exports.WORD_FREQUENCIES = {
-    daily: { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
-    "once daily": { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
-    once: { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
-    twice: { frequency: 2, periodUnit: types_1.FhirPeriodUnit.Day },
-    "twice daily": { frequency: 2, periodUnit: types_1.FhirPeriodUnit.Day },
-    "three times": { frequency: 3, periodUnit: types_1.FhirPeriodUnit.Day },
-    "three times daily": { frequency: 3, periodUnit: types_1.FhirPeriodUnit.Day }
-};
-exports.KNOWN_DOSAGE_FORMS_TO_DOSE = {
-    "nasal spray, suspension": "nasal spray",
-    "implantation chain": "implantation chain",
-    capsule: "capsule",
-    "capsule, soft": "capsule",
-    "oral solution": "solution",
-    "oral suspension": "suspension",
-    "inhalation powder": "inhalation",
-    "nasal spray, solution": "nasal spray",
-    "pressurised inhalation, suspension": "inhalation",
-    "pressurised inhalation, solution": "inhalation",
-    "rectal foam": "rectal foam",
-    "sublingual spray, solution": "sublingual spray",
-    "inhalation vapour, solution": "inhalation vapour",
-    "inhalation powder, pre-dispensed": "inhalation powder",
-    "solution for injection": "injection",
-    "inhalation solution": "inhalation",
-    cream: "cream",
-    "cutaneous powder": "cutaneous powder",
-    "powder for solution for injection": "powder for solution for injection",
-    gel: "gel",
-    "granules for oral solution": "granules for oral solution",
-    "powder for oral solution": "powder for oral solution",
-    "oral paste": "oral paste",
-    "cutaneous stick": "cutaneous stick",
-    "prolonged-release granules": "prolonged-release granules",
-    "oromucosal gel": "oromucosal gel",
-    "oral powder": "oral powder",
-    ointment: "ointment",
-    "cutaneous paste": "cutaneous paste",
-    "powder for oral suspension": "powder for oral suspension",
-    "vaginal gel": "vaginal gel",
-    "nasal drops, powder for solution": "nasal drops, powder for solution",
-    "oral gel": "oral gel",
-    "eye gel": "eye gel",
-    "impregnated dressing": "impregnated dressing",
-    "vaginal cream": "vaginal cream",
-    "ear powder": "ear powder",
-    "cutaneous emulsion": "cutaneous emulsion",
-    "cutaneous liquid": "cutaneous liquid",
-    "cutaneous solution": "cutaneous solution",
-    "effervescent powder": "effervescent powder",
-    "bath additive": "bath additive",
-    "nasal spray, powder for solution": "nasal spray, powder for solution",
-    "powder for cutaneous solution": "powder for cutaneous solution",
-    "dental gel": "dental gel",
-    "nasal gel": "nasal gel",
-    "powder for oral/rectal suspension": "powder for oral/rectal suspension",
-    "gingival gel": "gingival gel",
-    "powder for solution for infusion": "powder for solution for infusion",
-    "gastro-resistant granules": "gastro-resistant granules",
-    "eye ointment": "eye ointment",
-    "oromucosal spray, solution": "oromucosal spray, solution",
-    granules: "granules",
-    collodion: "collodion",
-    "powder for rectal solution": "powder for rectal solution",
-    "eye drops, solution": "eye drops, solution",
-    // additional helpers
-    "eye drops": "eye drops, solution",
-    "eye drop": "eye drops, solution",
-    "oromucosal paste": "oromucosal paste",
-    "dental paste": "dental paste",
-    "solution for peritoneal dialysis": "solution for peritoneal dialysis",
-    paste: "paste",
-    "effervescent granules": "effervescent granules",
-    shampoo: "shampoo",
-    "solution for infusion": "solution for infusion",
-    syrup: "syrup",
-    "oral liquid": "oral liquid",
-    "oral drops, solution": "oral drops, solution",
-    "emulsion for infusion": "emulsion for infusion",
-    "irrigation solution": "irrigation solution",
-    "solution for injection/infusion": "solution for injection/infusion",
-    "solution for haemodialysis/haemofiltration": "solution for haemodialysis/haemofiltration",
-    "solution for organ preservation": "solution for organ preservation",
-    "gargle/mouthwash": "gargle/mouthwash",
-    "concentrate for solution for injection/infusion": "concentrate for solution for injection/infusion",
-    "concentrate for cutaneous solution": "concentrate for cutaneous solution",
-    "cutaneous spray, solution": "cutaneous spray, solution",
-    "concentrate for dip solution": "concentrate for dip solution",
-    "oral emulsion": "oral emulsion",
-    "concentrate for oral solution": "concentrate for oral solution",
-    "concentrate for haemodialysis solution": "concentrate for haemodialysis solution",
-    "suspension for injection": "suspension for injection",
-    "powder and solvent for solution for injection": "powder and solvent for solution for injection",
-    "powder and suspension for suspension for injection": "powder and suspension for suspension for injection",
-    "powder for suspension for injection": "powder for suspension for injection",
-    "transdermal patch": "transdermal patch",
-    "powder and solvent for suspension for injection": "powder and solvent for suspension for injection",
-    "endotracheopulmonary instillation, powder for solution": "endotracheopulmonary instillation, powder for solution",
-    "intrauterine delivery system": "intrauterine delivery system",
-    implant: "implant",
-    "powder for solution for injection/infusion": "powder for solution for injection/infusion",
-    "concentrate for solution for injection": "concentrate for solution for injection",
-    "eye drops, emulsion": "eye drops, emulsion",
-    "concentrate for dispersion for injection": "concentrate for dispersion for injection",
-    "concentrate for solution for infusion": "concentrate for solution for infusion",
-    "concentrate and solvent for solution for infusion": "concentrate and solvent for solution for infusion",
-    "concentrate and solvent for suspension for injection": "concentrate and solvent for suspension for injection",
-    "gel for injection": "gel for injection",
-    "prolonged-release suspension for injection": "prolonged-release suspension for injection",
-    "rectal solution": "rectal solution",
-    "emulsion for injection": "emulsion for injection",
-    "oromucosal solution": "oromucosal solution",
-    "powder and solvent for solution for infusion": "powder and solvent for solution for infusion",
-    "emulsion for injection/infusion": "emulsion for injection/infusion",
-    "solution for cardioplegia": "solution for cardioplegia",
-    "endotracheopulmonary instillation, suspension": "endotracheopulmonary instillation, suspension",
-    "ear drops, solution": "ear drops, solution",
-    "eye drops, suspension": "eye drops, suspension",
-    "nasal drops, solution": "nasal drops, solution",
-    "suspension and solution for spray": "suspension and solution for spray",
-    "solution for sealant": "solution for sealant",
-    "inhalation vapour, liquid": "inhalation vapour, liquid",
-    "ear drops, suspension": "ear drops, suspension",
-    "dental suspension": "dental suspension",
-    "nebuliser solution": "nebuliser solution",
-    "concentrate for gargle": "concentrate for gargle",
-    "ear/eye drops, solution": "ear/eye drops, solution",
-    "ear wash, solution": "ear wash, solution",
-    "oromucosal drops": "oromucosal drops",
-    "powder for syrup": "powder for syrup",
-    "cutaneous suspension": "cutaneous suspension",
-    "eye lotion": "eye lotion",
-    "rectal suspension": "rectal suspension",
-    "intestinal gel": "intestinal gel",
-    "dental solution": "dental solution",
-    "gingival solution": "gingival solution",
-    "oral drops, suspension": "oral drops, suspension",
-    "eye drops, tablet and solvent for solution": "eye drops, tablet and solvent for solution",
-    "nebuliser suspension": "nebuliser suspension",
-    "dispersion for injection": "dispersion for injection",
-    "powder and solvent for oral solution": "powder and solvent for oral solution",
-    solution: "solution",
-    "powder and solvent for oral suspension": "powder and solvent for oral suspension",
-    "suspension and effervescent granules for oral suspension": "suspension and effervescent granules for oral suspension",
-    "oral drops, emulsion": "oral drops, emulsion",
-    "oral drops, liquid": "oral drops, liquid",
-    "oral/rectal suspension": "oral/rectal suspension",
-    "intravesical solution": "intravesical solution",
-    "granules for oral suspension": "granules for oral suspension",
-    "granules for syrup": "granules for syrup",
-    tablet: "tablet",
-    "film-coated tablet": "film-coated tablet",
-    "coated tablet": "coated tablet",
-    "chewable tablet": "chewable tablet",
-    "capsule, hard": "capsule, hard",
-    "gastro-resistant tablet": "gastro-resistant tablet",
-    "gastro-resistant granules for oral suspension": "gastro-resistant granules for oral suspension",
-    "orodispersible tablet": "orodispersible tablet",
-    "gastro-resistant capsule, hard": "gastro-resistant capsule, hard",
-    "prolonged-release capsule, hard": "prolonged-release capsule, hard",
-    "prolonged-release tablet": "prolonged-release tablet",
-    suppository: "suppository",
-    lozenge: "lozenge",
-    "modified-release tablet": "modified-release tablet",
-    "dispersible tablet": "dispersible tablet",
-    injection: "injection",
-    "powder for concentrate for solution for infusion": "powder for concentrate for solution for infusion",
-    "powder and solvent for solution for injection/infusion": "powder and solvent for solution for injection/infusion",
-    "powder and solvent for prolonged-release suspension for injection": "powder and solvent for prolonged-release suspension for injection",
-    "powder and solvent for concentrate for solution for infusion": "powder and solvent for concentrate for solution for infusion",
-    "sublingual tablet": "sublingual tablet",
-    "effervescent tablet": "effervescent tablet",
-    "vaginal tablet": "vaginal tablet",
-    "inhalation powder, hard capsule": "inhalation powder, hard capsule",
-    pessary: "pessary",
-    "vaginal capsule, hard": "vaginal capsule, hard",
-    pastille: "pastille",
-    "medicated chewing-gum": "medicated chewing-gum",
-    "vaginal delivery system": "vaginal delivery system",
-    "medicated plaster": "medicated plaster",
-    "intravitreal implant in applicator": "intravitreal implant in applicator",
-    "vaginal capsule, soft": "vaginal capsule, soft",
-    "lyophilisate and solvent for solution for injection": "lyophilisate and solvent for solution for injection",
-    "powder for concentrate for dispersion for infusion": "powder for concentrate for dispersion for infusion",
-    "powder for suspension for infusion": "powder for suspension for infusion",
-    "cutaneous patch": "cutaneous patch",
-    "modified-release capsule, hard": "modified-release capsule, hard",
-    "oral lyophilisate": "oral lyophilisate",
-    "powders for solution for injection": "powders for solution for injection",
-    "capsule, hard-capsule, soft-tablet": "capsule, hard-capsule, soft-tablet",
-    "capsule, hard-tablet": "capsule, hard-tablet"
-};
-/**
- * Map of normalized dosage-form labels to their associated SNOMED route code.
- * The keys intentionally mirror KNOWN_DOSAGE_FORMS_TO_DOSE to keep lookups simple.
- */
-exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE = {
-    "nasal spray, suspension": types_1.SNOMEDCTRouteCodes["Nasal route"],
-    "implantation chain": types_1.SNOMEDCTRouteCodes["Intralesional use"],
-    capsule: types_1.SNOMEDCTRouteCodes["Oral route"],
-    "capsule, soft": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "inhalation powder": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "nasal spray, solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
-    "pressurised inhalation, suspension": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "pressurised inhalation, solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "rectal foam": types_1.SNOMEDCTRouteCodes["Per rectum"],
-    "sublingual spray, solution": types_1.SNOMEDCTRouteCodes["Sublingual route"],
-    "inhalation vapour, solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "inhalation powder, pre-dispensed": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "inhalation solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    cream: types_1.SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous powder": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "powder for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    gel: types_1.SNOMEDCTRouteCodes["Topical route"],
-    "granules for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "powder for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral paste": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
-    "cutaneous stick": types_1.SNOMEDCTRouteCodes["Transdermal route"],
-    "prolonged-release granules": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oromucosal gel": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
-    "oral powder": types_1.SNOMEDCTRouteCodes["Oral route"],
-    ointment: types_1.SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous paste": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "powder for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "vaginal gel": types_1.SNOMEDCTRouteCodes["Per vagina"],
-    "nasal drops, powder for solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
-    "oral gel": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
-    "eye gel": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "impregnated dressing": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "vaginal cream": types_1.SNOMEDCTRouteCodes["Per vagina"],
-    "ear powder": types_1.SNOMEDCTRouteCodes["Otic route"],
-    "cutaneous emulsion": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous liquid": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous solution": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "effervescent powder": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "bath additive": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "nasal spray, powder for solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
-    "powder for cutaneous solution": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "dental gel": types_1.SNOMEDCTRouteCodes["Gingival use"],
-    "nasal gel": types_1.SNOMEDCTRouteCodes["Nasal route"],
-    "powder for oral/rectal suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "gingival gel": types_1.SNOMEDCTRouteCodes["Gingival use"],
-    "powder for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "gastro-resistant granules": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "eye ointment": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "oromucosal spray, solution": types_1.SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
-    granules: types_1.SNOMEDCTRouteCodes["Oral route"],
-    collodion: types_1.SNOMEDCTRouteCodes["Oral route"],
-    "powder for rectal solution": types_1.SNOMEDCTRouteCodes["Per rectum"],
-    "eye drops, solution": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "eye drops": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "eye drop": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "oromucosal paste": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
-    "dental paste": types_1.SNOMEDCTRouteCodes["Dental use"],
-    "solution for peritoneal dialysis": types_1.SNOMEDCTRouteCodes["Intradialytic route"],
-    paste: types_1.SNOMEDCTRouteCodes["Topical route"],
-    "effervescent granules": types_1.SNOMEDCTRouteCodes["Oral route"],
-    shampoo: types_1.SNOMEDCTRouteCodes["Topical route"],
-    "solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    syrup: types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral liquid": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral drops, solution": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "emulsion for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "irrigation solution": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "solution for haemodialysis/haemofiltration": types_1.SNOMEDCTRouteCodes["Intradialytic route"],
-    "solution for organ preservation": types_1.SNOMEDCTRouteCodes["Extracorporeal route (qualifier value)"],
-    "gargle/mouthwash": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
-    "concentrate for solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate for cutaneous solution": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "cutaneous spray, solution": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "concentrate for dip solution": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "oral emulsion": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "concentrate for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "concentrate for haemodialysis solution": types_1.SNOMEDCTRouteCodes["Intradialytic route"],
-    "suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and suspension for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "transdermal patch": types_1.SNOMEDCTRouteCodes["Transdermal route"],
-    "powder and solvent for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "endotracheopulmonary instillation, powder for solution": types_1.SNOMEDCTRouteCodes["Endotracheopulmonary use"],
-    "intrauterine delivery system": types_1.SNOMEDCTRouteCodes["Intrauterine route"],
-    implant: types_1.SNOMEDCTRouteCodes["Intradermal use"],
-    "powder for solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "eye drops, emulsion": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "concentrate for dispersion for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate and solvent for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate and solvent for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "gel for injection": types_1.SNOMEDCTRouteCodes["Intramuscular route"],
-    "prolonged-release suspension for injection": types_1.SNOMEDCTRouteCodes["Intramuscular route"],
-    "rectal solution": types_1.SNOMEDCTRouteCodes["Per rectum"],
-    "emulsion for injection": types_1.SNOMEDCTRouteCodes["Intramuscular route"],
-    "oromucosal solution": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
-    "powder and solvent for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "emulsion for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "solution for cardioplegia": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "endotracheopulmonary instillation, suspension": types_1.SNOMEDCTRouteCodes["Endotracheopulmonary use"],
-    "ear drops, solution": types_1.SNOMEDCTRouteCodes["Otic route"],
-    "eye drops, suspension": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "nasal drops, solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
-    "suspension and solution for spray": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "solution for sealant": types_1.SNOMEDCTRouteCodes["Topical route"],
-    "inhalation vapour, liquid": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "ear drops, suspension": types_1.SNOMEDCTRouteCodes["Otic route"],
-    "dental suspension": types_1.SNOMEDCTRouteCodes["Dental use"],
-    "nebuliser solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "concentrate for gargle": types_1.SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
-    "ear/eye drops, solution": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "ear wash, solution": types_1.SNOMEDCTRouteCodes["Otic route"],
-    "oromucosal drops": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
-    "powder for syrup": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "cutaneous suspension": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "eye lotion": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "rectal suspension": types_1.SNOMEDCTRouteCodes["Per rectum"],
-    "intestinal gel": types_1.SNOMEDCTRouteCodes["Intestinal route (qualifier value)"],
-    "dental solution": types_1.SNOMEDCTRouteCodes["Dental use"],
-    "gingival solution": types_1.SNOMEDCTRouteCodes["Gingival use"],
-    "oral drops, suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "eye drops, tablet and solvent for solution": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "nebuliser suspension": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "dispersion for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
-    solution: types_1.SNOMEDCTRouteCodes["Oral route"],
-    "powder and solvent for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "suspension and effervescent granules for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral drops, emulsion": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral drops, liquid": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral/rectal suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "intravesical solution": types_1.SNOMEDCTRouteCodes["Intralesional use"],
-    "granules for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "granules for syrup": types_1.SNOMEDCTRouteCodes["Oral route"],
-    tablet: types_1.SNOMEDCTRouteCodes["Oral route"],
-    "film-coated tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "coated tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "chewable tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "gastro-resistant tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "gastro-resistant granules for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "orodispersible tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "gastro-resistant capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "prolonged-release capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "prolonged-release tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    suppository: types_1.SNOMEDCTRouteCodes["Per rectum"],
-    lozenge: types_1.SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
-    "modified-release tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "dispersible tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    injection: types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for concentrate for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for prolonged-release suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for concentrate for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "sublingual tablet": types_1.SNOMEDCTRouteCodes["Sublingual route"],
-    "effervescent tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "vaginal tablet": types_1.SNOMEDCTRouteCodes["Per vagina"],
-    "inhalation powder, hard capsule": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    pessary: types_1.SNOMEDCTRouteCodes["Per vagina"],
-    "vaginal capsule, hard": types_1.SNOMEDCTRouteCodes["Per vagina"],
-    pastille: types_1.SNOMEDCTRouteCodes["Oral route"],
-    "medicated chewing-gum": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "vaginal delivery system": types_1.SNOMEDCTRouteCodes["Per vagina"],
-    "medicated plaster": types_1.SNOMEDCTRouteCodes["Transdermal route"],
-    "intravitreal implant in applicator": types_1.SNOMEDCTRouteCodes["Intravitreal route (qualifier value)"],
-    "vaginal capsule, soft": types_1.SNOMEDCTRouteCodes["Per vagina"],
-    "lyophilisate and solvent for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for concentrate for dispersion for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for suspension for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "cutaneous patch": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "modified-release capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "oral lyophilisate": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "powders for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
-    "capsule, hard-capsule, soft-tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
-    "capsule, hard-tablet": types_1.SNOMEDCTRouteCodes["Oral route"]
-};
-exports.DEFAULT_UNIT_BY_NORMALIZED_FORM = {
-    tab: "tab",
-    tabs: "tab",
-    tablet: "tab",
-    "film-coated tablet": "tab",
-    "coated tablet": "tab",
-    "chewable tablet": "tab",
-    "dispersible tablet": "tab",
-    "gastro-resistant tablet": "tab",
-    "modified-release tablet": "tab",
-    "orodispersible tablet": "tab",
-    capsule: "cap",
-    caps: "cap",
-    "capsule, soft": "cap",
-    "capsule, hard": "cap",
-    "gastro-resistant capsule, hard": "cap",
-    "prolonged-release capsule, hard": "cap",
-    "modified-release capsule, hard": "cap",
-    "inhalation powder, hard capsule": "cap",
-    solution: "mL",
-    "oral solution": "mL",
-    "solution for injection": "mL",
-    "solution for infusion": "mL",
-    suspension: "mL",
-    "oral suspension": "mL",
-    "powder for oral suspension": "mL",
-    syrup: "mL",
-    "oral liquid": "mL",
-    "oral drops, solution": "mL",
-    "oral drops, suspension": "mL",
-    "oral drops, emulsion": "mL",
-    "oral drops, liquid": "mL",
-    "oral emulsion": "mL",
-    "granules for oral solution": "mL",
-    "granules for oral suspension": "mL",
-    "nasal spray": "spray",
-    "nasal spray, suspension": "spray",
-    "nasal spray, solution": "spray",
-    "nasal spray, powder for solution": "spray",
-    "sublingual spray": "spray",
-    "sublingual spray, solution": "spray",
-    spray: "spray",
-    "cutaneous spray, solution": "spray",
-    inhalation: "puff",
-    "inhalation powder": "puff",
-    "pressurised inhalation, suspension": "puff",
-    "pressurised inhalation, solution": "puff",
-    "inhalation solution": "puff",
-    "inhalation vapour": "puff",
-    "inhalation vapour, solution": "puff",
-    "inhalation vapour, liquid": "puff",
-    "nebuliser solution": "puff",
-    "nebuliser suspension": "puff",
-    ointment: "g",
-    cream: "g",
-    gel: "g",
-    paste: "g",
-    "oral paste": "g",
-    suppository: "suppository",
-    suppositories: "suppository",
-    "rectal foam": "suppository",
-    "rectal solution": "suppository",
-    "rectal suspension": "suppository",
-    patch: "patch",
-    "transdermal patch": "patch",
-    "cutaneous patch": "patch",
-    "medicated plaster": "patch",
-    "cutaneous stick": "stick",
-    drop: "drop",
-    drops: "drop",
-    "eye drops, solution": "drop",
-    "eye drops, suspension": "drop",
-    "ear drops, solution": "drop",
-    "ear drops, suspension": "drop",
-    "ear/eye drops, solution": "drop",
-    lozenge: "lozenge",
-    pastille: "lozenge",
-    pessary: "pessary",
-    injection: "mL",
-    implant: "implant",
-    "implantation chain": "implant",
-    "intrauterine delivery system": "implant",
-    "intravitreal implant in applicator": "implant",
-    "medicated chewing-gum": "piece"
-};
-const ROUTE_UNIT_FALLBACK_WHITELIST = new Set([
-    "drop",
-    "puff",
-    "spray",
-    "patch",
-    "suppository",
-    "implant",
-    "piece",
-    "stick",
-    "pessary",
-    "lozenge"
-]);
-exports.DEFAULT_UNIT_BY_ROUTE = (() => {
-    const unitCandidates = new Map();
-    for (const [form, snomed] of (0, object_1.objectEntries)(exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE)) {
-        const routeCode = exports.ROUTE_BY_SNOMED[snomed];
-        if (!routeCode) {
-            continue;
-        }
-        const unit = exports.DEFAULT_UNIT_BY_NORMALIZED_FORM[form];
-        if (!unit) {
-            continue;
-        }
-        let unitsForRoute = unitCandidates.get(routeCode);
-        if (!unitsForRoute) {
-            unitsForRoute = new Set();
-            unitCandidates.set(routeCode, unitsForRoute);
-        }
-        unitsForRoute.add(unit);
-    }
-    const resolved = {};
-    for (const [route, units] of unitCandidates) {
-        if (units.size !== 1) {
-            continue;
-        }
-        const [unit] = Array.from(units);
-        if (unit && ROUTE_UNIT_FALLBACK_WHITELIST.has(unit)) {
-            resolved[route] = unit;
-        }
-    }
-    const ensure = (route, unit) => {
-        if (ROUTE_UNIT_FALLBACK_WHITELIST.has(unit)) {
-            resolved[route] = unit;
-        }
-    };
-    ensure(types_1.RouteCode["Ophthalmic route"], "drop");
-    ensure(types_1.RouteCode["Ocular route (qualifier value)"], "drop");
-    ensure(types_1.RouteCode["Otic route"], "drop");
-    ensure(types_1.RouteCode["Respiratory tract route (qualifier value)"], "puff");
-    ensure(types_1.RouteCode["Transdermal route"], "patch");
-    ensure(types_1.RouteCode["Per rectum"], "suppository");
-    return resolved;
-})();
-function normalizePrnReasonKey(value) {
-    return value
-        .trim()
-        .toLowerCase()
-        .replace(/[^\p{L}\p{N}]+/gu, " ")
-        .replace(/\s+/g, " ")
-        .trim();
-}
-function normalizeAdditionalInstructionKey(value) {
-    return value
-        .trim()
-        .toLowerCase()
-        .replace(/[^\p{L}\p{N}]+/gu, " ")
-        .replace(/\s+/g, " ")
-        .trim();
-}
-const DEFAULT_PRN_REASON_SOURCE = [
-    {
-        names: ["pain", "ache", "aches", "pains"],
-        definition: {
-            coding: { system: SNOMED_SYSTEM, code: "22253000", display: "Pain" },
-            text: "Pain",
-            i18n: { th: "ปวด" }
-        }
-    },
-    {
-        names: ["nausea", "queasiness", "vomiting", "n/v", "nausea and vomiting"],
-        definition: {
-            coding: { system: SNOMED_SYSTEM, code: "422587007", display: "Nausea" },
-            text: "Nausea",
-            i18n: { th: "คลื่นไส้" }
-        }
-    },
-    {
-        names: ["itch", "itching", "itchy"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "418363000",
-                display: "Itching of skin"
-            },
-            text: "Itching",
-            i18n: { th: "คัน" }
-        }
-    },
-    {
-        names: ["anxiety", "nervousness"],
-        definition: {
-            coding: { system: SNOMED_SYSTEM, code: "48694002", display: "Anxiety" },
-            text: "Anxiety",
-            i18n: { th: "วิตกกังวล" }
-        }
-    },
-    {
-        names: ["sleep", "sleeping", "insomnia", "sleep issues"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "193462001",
-                display: "Insomnia"
-            },
-            text: "Sleep",
-            i18n: { th: "นอนหลับ" }
-        }
-    },
-    {
-        names: ["sleepiness", "sleepy", "drowsiness", "drowsy"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "79519003",
-                display: "Drowsiness"
-            },
-            text: "Sleepiness",
-            i18n: { th: "ง่วงนอน" }
-        }
-    },
-    {
-        names: ["cough", "coughing"],
-        definition: {
-            coding: { system: SNOMED_SYSTEM, code: "49727002", display: "Cough" },
-            text: "Cough",
-            i18n: { th: "ไอ" }
-        }
-    },
-    {
-        names: ["fever", "temperature", "pyrexia"],
-        definition: {
-            coding: { system: SNOMED_SYSTEM, code: "386661006", display: "Fever" },
-            text: "Fever",
-            i18n: { th: "ไข้" }
-        }
-    },
-    {
-        names: ["spasm", "spasms", "muscle spasm"],
-        definition: {
-            coding: { system: SNOMED_SYSTEM, code: "45352006", display: "Spasm" },
-            text: "Spasm",
-            i18n: { th: "ตะคริวหรือเกร็ง" }
-        }
-    },
-    {
-        names: ["constipation"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "14760008",
-                display: "Constipation"
-            },
-            text: "Constipation",
-            i18n: { th: "ท้องผูก" }
-        }
-    },
-    {
-        names: ["irritation", "irritated"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "257553007",
-                display: "Irritation"
-            },
-            text: "Irritation",
-            i18n: { th: "ระคายเคือง" }
-        }
-    },
-    {
-        names: ["dyspnea", "shortness of breath", "sob", "breathlessness"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "267036007",
-                display: "Dyspnea"
-            },
-            text: "Shortness of breath",
-            i18n: { th: "เหนื่อยหรือหายใจลำบาก" }
-        }
-    }
-];
-exports.DEFAULT_PRN_REASON_ENTRIES = DEFAULT_PRN_REASON_SOURCE.map((source) => {
-    var _a, _b, _c;
-    const canonicalTerm = (_c = (_a = source.definition.text) !== null && _a !== void 0 ? _a : (_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.display) !== null && _c !== void 0 ? _c : source.names[0];
-    return {
-        canonical: normalizePrnReasonKey(canonicalTerm !== null && canonicalTerm !== void 0 ? canonicalTerm : ""),
-        definition: source.definition,
-        terms: [...source.names]
-    };
-});
-exports.DEFAULT_PRN_REASON_DEFINITIONS = (0, object_1.objectFromEntries)(DEFAULT_PRN_REASON_SOURCE.reduce((entries, source) => {
-    for (const name of source.names) {
-        const key = normalizePrnReasonKey(name);
-        if (!key) {
-            continue;
-        }
-        entries.push([key, source.definition]);
-    }
-    if (source.definition.aliases) {
-        for (const alias of source.definition.aliases) {
-            const key = normalizePrnReasonKey(alias);
-            if (!key) {
-                continue;
-            }
-            entries.push([key, source.definition]);
-        }
-    }
-    return entries;
-}, []));
-const DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE = [
-    {
-        names: ["with food", "with meals", "with meal", "after food", "after meals"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "311504000",
-                display: "With or after food"
-            },
-            text: "Take with or after food",
-            i18n: { th: "รับประทานพร้อมหรือหลังอาหาร" }
-        }
-    },
-    {
-        names: ["before food", "before meals", "before meal", "1 hour before food"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "311501008",
-                display: "Half to one hour before food"
-            },
-            text: "Take before food",
-            i18n: { th: "รับประทานก่อนอาหาร" }
-        }
-    },
-    {
-        names: ["empty stomach", "on empty stomach"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "717154004",
-                display: "Take on an empty stomach (qualifier value)"
-            },
-            text: "Take on an empty stomach",
-            i18n: { th: "รับประทานขณะท้องว่าง" }
-        }
-    },
-    {
-        names: ["with water", "with plenty of water", "drink water", "with lots of water"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "419303009",
-                display: "With plenty of water"
-            },
-            text: "Take with plenty of water",
-            i18n: { th: "รับประทานพร้อมน้ำดื่มจำนวนมาก" }
-        }
-    },
-    {
-        names: ["dissolve in water", "mix with water", "mix in water"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "417995008",
-                display: "Dissolve or mix with water before taking"
-            },
-            text: "Dissolve or mix with water before taking",
-            i18n: { th: "ละลายหรือผสมน้ำก่อนรับประทาน" }
-        }
-    },
-    {
-        names: ["avoid alcohol", "no alcohol", "no alc", "avoid alcoholic drink"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "419822006",
-                display: "Warning. Avoid alcoholic drink (qualifier value)"
-            },
-            text: "Avoid alcoholic drinks",
-            i18n: { th: "หลีกเลี่ยงเครื่องดื่มแอลกอฮอล์" }
-        }
-    },
-    {
-        names: ["may cause drowsiness", "do not drive", "avoid driving", "no driving", "no drive"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "418954008",
-                display: "Warning. May cause drowsiness. If affected do not drive or operate machinery (qualifier value)"
-            },
-            text: "May cause drowsiness; do not drive if affected",
-            i18n: { th: "อาจทำให้ง่วงซึม; ห้ามขับขี่ยานพาหนะหรือทำงานกับเครื่องจักรหากมีอาการ" }
-        }
-    },
-    {
-        names: [
-            "drowsiness avoid alcohol",
-            "may cause drowsiness avoid alcohol",
-            "do not drive avoid alcohol",
-            "drowsy avoid alc",
-            "drowsy avoid drive",
-            "drowsy avoid driving",
-            "drowsy no drive",
-            "drowsy no driving",
-            "drowsy no alc"
-        ],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "418914006",
-                display: "Warning. May cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink (qualifier value)"
-            },
-            text: "May cause drowsiness; avoid driving or alcohol",
-            i18n: { th: "อาจทำให้ง่วงซึม; หลีกเลี่ยงการขับขี่ยานพาหนะหรือดื่มแอลกอฮอล์" }
-        }
-    },
-    {
-        names: [
-            "drowsiness next day",
-            "drowsiness next day avoid alcohol",
-            "may cause drowsiness next day",
-            "may next day drowsy",
-            "may drowsy next day"
-        ],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "418071006",
-                display: "Warning. Causes drowsiness which may continue the next day. If affected do not drive or operate machinery. Avoid alcoholic drink (qualifier value)"
-            },
-            text: "May cause next-day drowsiness; avoid driving or alcohol",
-            i18n: { th: "อาจทำให้ง่วงซึมในวันถัดมา; หลีกเลี่ยงการขับขี่ยานพาหนะหรือดื่มแอลกอฮอล์" }
-        }
-    },
-    {
-        names: ["avoid sun", "avoid sunlight", "avoid sun lamps"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "418521000",
-                display: "Avoid exposure of skin to direct sunlight or sun lamps (qualifier value)"
-            },
-            text: "Avoid sunlight or sun lamps",
-            i18n: { th: "หลีกเลี่ยงแสงแดดหรือหลอดไฟแสงยูวี" }
-        }
-    },
-    {
-        names: ["swallow whole", "do not chew", "do not crush", "do not crush or chew", "no chewing"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "418693002",
-                display: "Swallowed whole, not chewed (qualifier value)"
-            },
-            text: "Swallow whole; do not crush or chew",
-            i18n: { th: "กลืนทั้งเม็ด; ห้ามเคี้ยวหรือบด" }
-        }
-    },
-    {
-        names: ["chew", "chewed", "sucked or chewed", "please chew", "must chew"],
-        definition: {
-            coding: {
-                system: SNOMED_SYSTEM,
-                code: "418991002",
-                display: "Sucked or chewed (qualifier value)"
-            },
-            text: "Suck or chew before swallowing",
-            i18n: { th: "เคี้ยวหรืออมให้ละลายก่อนกลืน" }
-        }
-    }
-];
-exports.DEFAULT_ADDITIONAL_INSTRUCTION_ENTRIES = DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE.map((source) => {
-    var _a, _b, _c;
-    const canonicalTerm = (_c = (_a = source.definition.text) !== null && _a !== void 0 ? _a : (_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.display) !== null && _c !== void 0 ? _c : source.names[0];
-    return {
-        canonical: normalizeAdditionalInstructionKey(canonicalTerm !== null && canonicalTerm !== void 0 ? canonicalTerm : ""),
-        definition: source.definition,
-        terms: [...source.names]
-    };
-});
-exports.DEFAULT_ADDITIONAL_INSTRUCTION_DEFINITIONS = (0, object_1.objectFromEntries)(DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE.reduce((entries, source) => {
-    for (const name of source.names) {
-        const key = normalizeAdditionalInstructionKey(name);
-        if (!key) {
-            continue;
-        }
-        entries.push([key, source.definition]);
-    }
-    if (source.definition.aliases) {
-        for (const alias of source.definition.aliases) {
-            const key = normalizeAdditionalInstructionKey(alias);
-            if (!key) {
-                continue;
-            }
-            entries.push([key, source.definition]);
-        }
-    }
-    return entries;
-}, []));
-/**
- * Finds a default PRN reason definition by its SNOMED coding.
- */
-function findPrnReasonDefinitionByCoding(system, code) {
-    var _a;
-    return (_a = DEFAULT_PRN_REASON_SOURCE.find((source) => { var _a, _b; return ((_a = source.definition.coding) === null || _a === void 0 ? void 0 : _a.system) === system && ((_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.code) === code; })) === null || _a === void 0 ? void 0 : _a.definition;
-}
-/**
- * Finds a default additional instruction definition by its SNOMED coding.
- */
-function findAdditionalInstructionDefinitionByCoding(system, code) {
-    var _a;
-    return (_a = DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE.find((source) => { var _a, _b; return ((_a = source.definition.coding) === null || _a === void 0 ? void 0 : _a.system) === system && ((_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.code) === code; })) === null || _a === void 0 ? void 0 : _a.definition;
-}