ezmedicationinput 0.1.43 → 0.1.44

package/dist/maps.js

@@ -1,13 +1,13 @@
 "use strict";
 Object.defineProperty(exports, "__esModule", { value: true });
-exports.DEFAULT_ADDITIONAL_INSTRUCTION_DEFINITIONS = exports.DEFAULT_ADDITIONAL_INSTRUCTION_ENTRIES = exports.DEFAULT_PRN_REASON_DEFINITIONS = exports.DEFAULT_PRN_REASON_ENTRIES = exports.DEFAULT_UNIT_BY_ROUTE = exports.DEFAULT_UNIT_BY_NORMALIZED_FORM = exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE = exports.KNOWN_DOSAGE_FORMS_TO_DOSE = exports.WORD_FREQUENCIES = exports.DAY_OF_WEEK_TOKENS = exports.DISCOURAGED_TOKENS = exports.MEAL_KEYWORDS = exports.EVENT_TIMING_TOKENS = exports.TIMING_ABBREVIATIONS = exports.DEFAULT_UNIT_SYNONYMS = exports.HOUSEHOLD_VOLUME_UNITS = exports.DEFAULT_BODY_SITE_SNOMED = exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = exports.DEFAULT_ROUTE_SYNONYMS = exports.ROUTE_BY_SNOMED = exports.ROUTE_TEXT = exports.ROUTE_SNOMED = void 0;
+exports.DEFAULT_PRN_REASON_DEFINITIONS = exports.DEFAULT_PRN_REASON_ENTRIES = exports.DEFAULT_UNIT_BY_ROUTE = exports.DEFAULT_UNIT_BY_NORMALIZED_FORM = exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE = exports.KNOWN_DOSAGE_FORMS_TO_DOSE = exports.WORD_FREQUENCIES = exports.DAY_OF_WEEK_TOKENS = exports.DISCOURAGED_TOKENS = exports.MEAL_KEYWORDS = exports.EVENT_TIMING_TOKENS = exports.TIMING_ABBREVIATIONS = exports.PRODUCT_FORM_HINTS = exports.DEFAULT_UNIT_SYNONYMS = exports.HOUSEHOLD_VOLUME_UNITS = exports.DEFAULT_BODY_SITE_HINTS = exports.DEFAULT_BODY_SITE_SNOMED = exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = exports.DEFAULT_ROUTE_SYNONYMS = exports.ROUTE_BY_SNOMED = exports.ROUTE_TEXT = exports.ROUTE_SNOMED = void 0;
 exports.normalizeBodySiteKey = normalizeBodySiteKey;
 exports.normalizePrnReasonKey = normalizePrnReasonKey;
 exports.normalizeAdditionalInstructionKey = normalizeAdditionalInstructionKey;
 exports.findPrnReasonDefinitionByCoding = findPrnReasonDefinitionByCoding;
-exports.findAdditionalInstructionDefinitionByCoding = findAdditionalInstructionDefinitionByCoding;
 const types_1 = require("./types");
 const object_1 = require("./utils/object");
+const text_1 = require("./utils/text");
 const SNOMED_SYSTEM = "http://snomed.info/sct";
 const ROUTE_TEXT_OVERRIDES = {
     [types_1.RouteCode["Oral route"]]: "by mouth",
@@ -179,86 +179,99 @@ exports.DEFAULT_ROUTE_SYNONYMS = (() => {
  * same logic to ensure consistent lookups.
  */
 function normalizeBodySiteKey(value) {
-    return value
-        .trim()
-        .toLowerCase()
-        .replace(/[^\p{L}\p{N}]+/gu, " ")
-        .replace(/\s+/g, " ")
-        .trim();
+    return (0, text_1.normalizeLoosePhraseKey)(value);
 }
 exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = [
     {
         names: ["eye", "eyes"],
-        definition: { coding: { code: "81745001", display: "Eye" } }
+        definition: {
+            coding: { code: "81745001", display: "Eye" },
+            routeHint: types_1.RouteCode["Ophthalmic route"]
+        }
     },
     {
         names: ["left eye"],
         definition: {
-            coding: { code: "1290031003", display: "Structure of left eye proper" }
+            coding: { code: "1290031003", display: "Structure of left eye proper" },
+            routeHint: types_1.RouteCode["Ophthalmic route"]
         }
     },
     {
         names: ["right eye"],
         definition: {
-            coding: { code: "1290032005", display: "Structure of right eye proper" }
+            coding: { code: "1290032005", display: "Structure of right eye proper" },
+            routeHint: types_1.RouteCode["Ophthalmic route"]
         }
     },
     {
         names: ["both eyes", "bilateral eyes"],
-        definition: { coding: { code: "40638003", display: "Structure of both eyes" } }
+        definition: {
+            coding: { code: "40638003", display: "Structure of both eyes" },
+            routeHint: types_1.RouteCode["Ophthalmic route"]
+        }
     },
     {
         names: ["ear", "ears"],
-        definition: { coding: { code: "117590005", display: "Ear-related structure" } }
+        definition: {
+            coding: { code: "117590005", display: "Ear-related structure" },
+            routeHint: types_1.RouteCode["Otic route"]
+        }
     },
     {
         names: ["left ear"],
-        definition: { coding: { code: "89644007", display: "Left ear" } }
+        definition: { coding: { code: "89644007", display: "Left ear" }, routeHint: types_1.RouteCode["Otic route"] }
     },
     {
         names: ["right ear"],
-        definition: { coding: { code: "25577004", display: "Right ear" } }
+        definition: { coding: { code: "25577004", display: "Right ear" }, routeHint: types_1.RouteCode["Otic route"] }
     },
     {
         names: ["both ears", "bilateral ears"],
-        definition: { coding: { code: "34338003", display: "Both ears" } }
+        definition: { coding: { code: "34338003", display: "Both ears" }, routeHint: types_1.RouteCode["Otic route"] }
     },
     {
         names: ["nostril", "nostrils"],
-        definition: { coding: { code: "1797002", display: "Naris" } }
+        definition: { coding: { code: "1797002", display: "Naris" }, routeHint: types_1.RouteCode["Nasal route"] }
     },
     {
         names: ["left nostril", "left naris"],
         definition: {
-            coding: { code: "723608007", display: "Structure of left anterior naris" }
+            coding: { code: "723608007", display: "Structure of left anterior naris" },
+            routeHint: types_1.RouteCode["Nasal route"]
         }
     },
     {
         names: ["right nostril", "right naris"],
         definition: {
-            coding: { code: "723609004", display: "Structure of right anterior naris" }
+            coding: { code: "723609004", display: "Structure of right anterior naris" },
+            routeHint: types_1.RouteCode["Nasal route"]
         }
     },
     {
         names: ["nares", "anterior nares"],
-        definition: { coding: { code: "244506005", display: "Anterior nares" } }
+        definition: { coding: { code: "244506005", display: "Anterior nares" }, routeHint: types_1.RouteCode["Nasal route"] }
     },
     {
         names: ["nose"],
-        definition: { coding: { code: "181195007", display: "Entire nose" } }
+        definition: { coding: { code: "181195007", display: "Entire nose" }, routeHint: types_1.RouteCode["Nasal route"] }
     },
     {
         names: ["mouth"],
-        definition: { coding: { code: "123851003", display: "Mouth region" } }
+        definition: { coding: { code: "123851003", display: "Mouth region" }, routeHint: types_1.RouteCode["Oral route"] }
     },
     {
         names: ["tongue", "tongues"],
-        definition: { coding: { code: "21974007", display: "Tongue" } }
+        definition: { coding: { code: "21974007", display: "Tongue" }, routeHint: types_1.RouteCode["Sublingual route"] }
+    },
+    {
+        names: ["lip", "lips"],
+        definition: { coding: { code: "48477009", display: "Lip structure" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["cheek", "cheeks"],
         definition: {
-            coding: { code: "60819002", display: "Buccal region of face" }
+            coding: { code: "60819002", display: "Buccal region of face" },
+            routeHint: types_1.RouteCode["Buccal route"]
         }
     },
     {
@@ -267,120 +280,271 @@ exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = [
             coding: {
                 code: "362116001",
                 display: "Entire gum and supporting structure of tooth"
-            }
+            },
+            routeHint: types_1.RouteCode["Topical route"]
         }
     },
     {
         names: ["tooth"],
-        definition: { coding: { code: "38199008", display: "Tooth" } }
+        definition: { coding: { code: "38199008", display: "Tooth" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["teeth"],
-        definition: { coding: { code: "1162715001", display: "All teeth" } }
+        definition: { coding: { code: "1162715001", display: "All teeth" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["arm", "upper arm"],
-        definition: { coding: { code: "302538001", display: "Entire upper arm" } }
+        definition: { coding: { code: "302538001", display: "Entire upper arm" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["left arm", "left upper arm"],
         definition: {
-            coding: { code: "368208006", display: "Left upper arm structure" }
+            coding: { code: "368208006", display: "Left upper arm structure" },
+            routeHint: types_1.RouteCode["Topical route"]
         }
     },
     {
         names: ["right arm", "right upper arm"],
-        definition: { coding: { code: "368209003", display: "Right upper arm" } }
+        definition: { coding: { code: "368209003", display: "Right upper arm" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["both arms", "bilateral arms"],
-        definition: { coding: { code: "69273007", display: "Both arms" } }
+        definition: { coding: { code: "69273007", display: "Both arms" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["shoulder", "shoulders"],
+        definition: { coding: { code: "16982005", display: "Shoulder region structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left shoulder"],
+        definition: { coding: { code: "91775009", display: "Left shoulder" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right shoulder"],
+        definition: { coding: { code: "91774008", display: "Right shoulder" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["forearm"],
-        definition: { coding: { code: "14975008", display: "Forearm" } }
+        definition: { coding: { code: "14975008", display: "Forearm" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["left forearm"],
-        definition: { coding: { code: "66480008", display: "Left forearm" } }
+        definition: { coding: { code: "66480008", display: "Left forearm" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["right forearm"],
-        definition: { coding: { code: "64262003", display: "Right forearm" } }
+        definition: { coding: { code: "64262003", display: "Right forearm" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["elbow"],
+        definition: { coding: { code: "127949000", display: "Elbow region structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left elbow"],
+        definition: { coding: { code: "368148009", display: "Left elbow" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right elbow"],
+        definition: { coding: { code: "368149001", display: "Right elbow" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["leg", "lower leg"],
         definition: {
-            coding: { code: "362793004", display: "Entire lower leg, from knee to ankle" }
+            coding: { code: "362793004", display: "Entire lower leg, from knee to ankle" },
+            routeHint: types_1.RouteCode["Topical route"]
         }
     },
     {
         names: ["left leg", "left lower leg"],
-        definition: { coding: { code: "213384005", display: "Entire left lower leg" } }
+        definition: { coding: { code: "213384005", display: "Entire left lower leg" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["right leg", "right lower leg"],
-        definition: { coding: { code: "213289002", display: "Entire right lower leg" } }
+        definition: { coding: { code: "213289002", display: "Entire right lower leg" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["both legs", "bilateral legs"],
-        definition: { coding: { code: "40927001", display: "Both legs" } }
+        definition: { coding: { code: "40927001", display: "Both legs" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["thigh"],
-        definition: { coding: { code: "68367000", display: "Thigh" } }
+        definition: { coding: { code: "68367000", display: "Thigh" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["left thigh"],
-        definition: { coding: { code: "61396006", display: "Left thigh" } }
+        definition: { coding: { code: "61396006", display: "Left thigh" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["right thigh"],
-        definition: { coding: { code: "11207009", display: "Right thigh" } }
+        definition: { coding: { code: "11207009", display: "Right thigh" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["knee"],
+        definition: { coding: { code: "72696002", display: "Knee region structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left knee"],
+        definition: { coding: { code: "82169009", display: "Left knee" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right knee"],
+        definition: { coding: { code: "6757004", display: "Right knee" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["both knees", "bilateral knees"],
+        definition: { coding: { code: "36701003", display: "Both knees" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["wrist"],
+        definition: { coding: { code: "8205005", display: "Wrist region structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left wrist"],
+        definition: { coding: { code: "5951000", display: "Structure of left wrist" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right wrist"],
+        definition: { coding: { code: "9736006", display: "Structure of right wrist" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["ankle"],
+        definition: { coding: { code: "344001", display: "Ankle region structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left ankle"],
+        definition: { coding: { code: "51636004", display: "Structure of left ankle" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right ankle"],
+        definition: { coding: { code: "6685009", display: "Structure of right ankle" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["both ankles", "bilateral ankles"],
+        definition: { coding: { code: "69948000", display: "Both ankles" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["hip"],
+        definition: { coding: { code: "29836001", display: "Hip region structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left hip"],
+        definition: { coding: { code: "287679003", display: "Left hip" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right hip"],
+        definition: { coding: { code: "287579007", display: "Right hip" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["hand", "hands"],
-        definition: { coding: { code: "85562004", display: "Hand" } }
+        definition: { coding: { code: "85562004", display: "Hand" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["left hand"],
-        definition: { coding: { code: "85151006", display: "Left hand" } }
+        definition: { coding: { code: "85151006", display: "Left hand" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["right hand"],
-        definition: { coding: { code: "78791008", display: "Right hand" } }
+        definition: { coding: { code: "78791008", display: "Right hand" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["foot", "feet"],
-        definition: { coding: { code: "56459004", display: "Foot" } }
+        definition: { coding: { code: "56459004", display: "Foot" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["left foot"],
-        definition: { coding: { code: "22335008", display: "Left foot" } }
+        definition: { coding: { code: "22335008", display: "Left foot" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["right foot"],
-        definition: { coding: { code: "7769000", display: "Right foot" } }
+        definition: { coding: { code: "7769000", display: "Right foot" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["abdomen", "abdominal", "belly"],
-        definition: { coding: { code: "302553009", display: "Entire abdomen" } }
+        definition: { coding: { code: "302553009", display: "Entire abdomen" }, routeHint: types_1.RouteCode["Subcutaneous route"] }
+    },
+    {
+        names: ["head"],
+        definition: { coding: { code: "69536005", display: "Head structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["affected area", "affected areas", "affected site", "บริเวณที่เป็น"],
+        definition: { text: "affected area", routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left head", "left side of head"],
+        definition: { coding: { code: "64237003", display: "Structure of left half of head" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right head", "right side of head"],
+        definition: { coding: { code: "29624005", display: "Structure of right half of head" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["back"],
-        definition: { coding: { code: "77568009", display: "Back" } }
+        definition: { coding: { code: "77568009", display: "Back" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["chest"],
+        definition: { coding: { code: "51185008", display: "Thoracic structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["chest wall"],
+        definition: { coding: { code: "78904004", display: "Chest wall structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["breast"],
+        definition: { coding: { code: "76752008", display: "Breast structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left breast"],
+        definition: { coding: { code: "80248007", display: "Left breast" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right breast"],
+        definition: { coding: { code: "73056007", display: "Right breast" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["both breasts", "bilateral breasts"],
+        definition: { coding: { code: "63762007", display: "Both breasts" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["axilla", "axillae", "armpit", "armpits"],
+        definition: { coding: { code: "34797008", display: "Axilla structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["groin"],
+        definition: { coding: { code: "26893007", display: "Inguinal region structure" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["scalp"],
-        definition: { coding: { code: "41695006", display: "Scalp" } }
+        definition: { coding: { code: "41695006", display: "Scalp" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["face"],
-        definition: { coding: { code: "89545001", display: "Face" } }
+        definition: { coding: { code: "89545001", display: "Face" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["eyelid", "eyelids"],
+        definition: { coding: { code: "80243003", display: "Eyelid" }, routeHint: types_1.RouteCode["Ophthalmic route"] }
     },
     {
         names: ["forehead"],
-        definition: { coding: { code: "52795006", display: "Forehead" } }
+        definition: { coding: { code: "52795006", display: "Forehead" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["temple", "temple region", "temporal region"],
+        definition: { coding: { code: "450721000", display: "Temple region structure" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["temples", "both temples", "bilateral temples"],
+        definition: { coding: { code: "362620003", display: "Entire temporal region" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["left temple", "left temple region", "left temporal region"],
+        definition: { coding: { code: "1373280005", display: "Left temple region" }, routeHint: types_1.RouteCode["Topical route"] }
+    },
+    {
+        names: ["right temple", "right temple region", "right temporal region"],
+        definition: { coding: { code: "1373281009", display: "Right temple region" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["chin"],
@@ -388,24 +552,25 @@ exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = [
             coding: {
                 code: "897081006",
                 display: "Skin and/or subcutaneous tissue of chin"
-            }
+            },
+            routeHint: types_1.RouteCode["Topical route"]
         }
     },
     {
         names: ["neck"],
-        definition: { coding: { code: "45048000", display: "Neck" } }
+        definition: { coding: { code: "45048000", display: "Neck" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["buttock", "buttocks", "gluteal", "glute"],
-        definition: { coding: { code: "46862004", display: "Buttock" } }
+        definition: { coding: { code: "46862004", display: "Buttock" }, routeHint: types_1.RouteCode["Intramuscular route"] }
     },
     {
         names: ["left buttock", "left gluteal"],
-        definition: { coding: { code: "723979003", display: "Structure of left buttock" } }
+        definition: { coding: { code: "723979003", display: "Structure of left buttock" }, routeHint: types_1.RouteCode["Intramuscular route"] }
     },
     {
         names: ["right buttock", "right gluteal"],
-        definition: { coding: { code: "723980000", display: "Structure of right buttock" } }
+        definition: { coding: { code: "723980000", display: "Structure of right buttock" }, routeHint: types_1.RouteCode["Intramuscular route"] }
     },
     {
         names: ["muscle", "muscles"],
@@ -413,41 +578,43 @@ exports.DEFAULT_BODY_SITE_SNOMED_SOURCE = [
             coding: {
                 code: "362876008",
                 display: "All skeletal and smooth muscles of the body"
-            }
+            },
+            routeHint: types_1.RouteCode["Intramuscular route"]
         }
     },
     {
         names: ["vein", "veins"],
-        definition: { coding: { code: "181367001", display: "Entire vein" } }
+        definition: { coding: { code: "181367001", display: "Entire vein" }, routeHint: types_1.RouteCode["Intravenous route"] }
     },
     {
         names: ["vagina", "vaginal"],
-        definition: { coding: { code: "76784001", display: "Vagina" } }
+        definition: { coding: { code: "76784001", display: "Vagina" }, routeHint: types_1.RouteCode["Per vagina"] }
     },
     {
         names: ["penis", "penile"],
-        definition: { coding: { code: "18911002", display: "Penis structure" } }
+        definition: { coding: { code: "18911002", display: "Penis structure" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["rectum", "rectal"],
-        definition: { coding: { code: "34402009", display: "Rectum" } }
+        definition: { coding: { code: "34402009", display: "Rectum" }, routeHint: types_1.RouteCode["Per rectum"] }
     },
     {
         names: ["anus"],
-        definition: { coding: { code: "181262009", display: "Entire anus" } }
+        definition: { coding: { code: "181262009", display: "Entire anus" }, routeHint: types_1.RouteCode["Per rectum"] }
     },
     {
         names: ["perineum"],
-        definition: { coding: { code: "243990009", display: "Entire perineum" } }
+        definition: { coding: { code: "243990009", display: "Entire perineum" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["skin"],
-        definition: { coding: { code: "181469002", display: "Entire skin" } }
+        definition: { coding: { code: "181469002", display: "Entire skin" }, routeHint: types_1.RouteCode["Topical route"] }
     },
     {
         names: ["hair"],
         definition: {
-            coding: { code: "386045008", display: "Hair structure (body structure)" }
+            coding: { code: "386045008", display: "Hair structure (body structure)" },
+            routeHint: types_1.RouteCode["Topical route"]
         }
     }
 ];
@@ -462,6 +629,29 @@ exports.DEFAULT_BODY_SITE_SNOMED = (0, object_1.objectFromEntries)(exports.DEFAU
     }
     return entries;
 }, []));
+exports.DEFAULT_BODY_SITE_HINTS = (() => {
+    const hints = new Set();
+    const addPhrase = (phrase) => {
+        const normalized = normalizeBodySiteKey(phrase !== null && phrase !== void 0 ? phrase : "");
+        if (!normalized) {
+            return;
+        }
+        for (const part of normalized.split(" ")) {
+            if (part) {
+                hints.add(part);
+            }
+        }
+    };
+    for (const [key, definition] of (0, object_1.objectEntries)(exports.DEFAULT_BODY_SITE_SNOMED)) {
+        addPhrase(key);
+        if (definition.aliases) {
+            for (const alias of definition.aliases) {
+                addPhrase(alias);
+            }
+        }
+    }
+    return hints;
+})();
 const UNIT_PREFIXES = [
     { canonical: "", abbreviations: [""], names: [{ singular: "", plural: "" }] },
     {
@@ -569,6 +759,19 @@ const STATIC_UNIT_SYNONYMS = {
     sprays: "spray",
     drop: "drop",
     drops: "drop",
+    pump: "pump",
+    pumps: "pump",
+    squeeze: "squeeze",
+    squeezes: "squeeze",
+    applicatorful: "applicatorful",
+    applicatorfuls: "applicatorful",
+    capful: "capful",
+    capfuls: "capful",
+    scoop: "scoop",
+    scoops: "scoop",
+    application: "application",
+    applications: "application",
+    ribbon: "ribbon",
     patch: "patch",
     patches: "patch",
     supp: "suppository",
@@ -592,6 +795,27 @@ exports.DEFAULT_UNIT_SYNONYMS = (() => {
     addMetricUnitSynonyms(map);
     return map;
 })();
+exports.PRODUCT_FORM_HINTS = {
+    cream: { routeHint: types_1.RouteCode["Topical route"] },
+    ointment: { routeHint: types_1.RouteCode["Topical route"] },
+    gel: { routeHint: types_1.RouteCode["Topical route"] },
+    lotion: { routeHint: types_1.RouteCode["Topical route"] },
+    serum: { routeHint: types_1.RouteCode["Topical route"] },
+    toner: { routeHint: types_1.RouteCode["Topical route"] },
+    moisturizer: { routeHint: types_1.RouteCode["Topical route"] },
+    shampoo: { routeHint: types_1.RouteCode["Topical route"] },
+    sunscreen: { routeHint: types_1.RouteCode["Topical route"] },
+    deodorant: { routeHint: types_1.RouteCode["Topical route"] },
+    cleanser: { routeHint: types_1.RouteCode["Topical route"] },
+    "face wash": { routeHint: types_1.RouteCode["Topical route"] },
+    "body wash": { routeHint: types_1.RouteCode["Topical route"] },
+    "body lotion": { routeHint: types_1.RouteCode["Topical route"] },
+    "lip balm": { routeHint: types_1.RouteCode["Topical route"] },
+    "spot treatment": { routeHint: types_1.RouteCode["Topical route"] },
+    "makeup remover": { routeHint: types_1.RouteCode["Topical route"] },
+    balm: { routeHint: types_1.RouteCode["Topical route"] },
+    foam: { routeHint: types_1.RouteCode["Topical route"] }
+};
 exports.TIMING_ABBREVIATIONS = {
     qd: {
         code: "QD",
@@ -661,7 +885,9 @@ exports.TIMING_ABBREVIATIONS = {
     mo: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
     monthly: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
     am: { code: "AM", when: [types_1.EventTiming.Morning] },
-    pm: { code: "PM", when: [types_1.EventTiming.Evening] }
+    pm: { code: "PM", when: [types_1.EventTiming.Evening] },
+    qam: { code: "QAM", when: [types_1.EventTiming.Morning] },
+    qpm: { code: "QPM", when: [types_1.EventTiming.Evening] }
 };
 exports.EVENT_TIMING_TOKENS = {
     ac: types_1.EventTiming["Before Meal"],
@@ -708,8 +934,11 @@ exports.EVENT_TIMING_TOKENS = {
     afternoon: types_1.EventTiming.Afternoon,
     aft: types_1.EventTiming.Afternoon,
     pm: types_1.EventTiming.Evening,
+    qam: types_1.EventTiming.Morning,
+    qpm: types_1.EventTiming.Evening,
     evening: types_1.EventTiming.Evening,
     night: types_1.EventTiming.Night,
+    nightly: types_1.EventTiming.Night,
     hs: types_1.EventTiming["Before Sleep"],
     bedtime: types_1.EventTiming["Before Sleep"],
     bed: types_1.EventTiming["Before Sleep"],
@@ -793,7 +1022,6 @@ exports.DAY_OF_WEEK_TOKENS = {
 exports.WORD_FREQUENCIES = {
     daily: { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
     "once daily": { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
-    once: { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
     twice: { frequency: 2, periodUnit: types_1.FhirPeriodUnit.Day },
     "twice daily": { frequency: 2, periodUnit: types_1.FhirPeriodUnit.Day },
     "three times": { frequency: 3, periodUnit: types_1.FhirPeriodUnit.Day },
@@ -1309,20 +1537,10 @@ exports.DEFAULT_UNIT_BY_ROUTE = (() => {
     return resolved;
 })();
 function normalizePrnReasonKey(value) {
-    return value
-        .trim()
-        .toLowerCase()
-        .replace(/[^\p{L}\p{N}]+/gu, " ")
-        .replace(/\s+/g, " ")
-        .trim();
+    return (0, text_1.normalizeLoosePhraseKey)(value);
 }
 function normalizeAdditionalInstructionKey(value) {
-    return value
-        .trim()
-        .toLowerCase()
-        .replace(/[^\p{L}\p{N}]+/gu, " ")
-        .replace(/\s+/g, " ")
-        .trim();
+    return (0, text_1.normalizeLoosePhraseKey)(value);
 }
 const DEFAULT_PRN_REASON_SOURCE = [
     {
@@ -1330,59 +1548,261 @@ const DEFAULT_PRN_REASON_SOURCE = [
         definition: {
             coding: { system: SNOMED_SYSTEM, code: "22253000", display: "Pain" },
             text: "Pain",
+            aliases: ["เจ็บ", "ปวด"],
             i18n: { th: "ปวด" }
         }
     },
     {
-        names: ["nausea", "queasiness", "vomiting", "n/v", "nausea and vomiting"],
+        names: ["headache", "head pain"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "25064002", display: "Headache" },
+            text: "Headache",
+            aliases: ["ปวดหัว", "ปวดศีรษะ"],
+            i18n: { th: "ปวดศีรษะ" }
+        }
+    },
+    {
+        names: ["migraine", "migraine headache"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "37796009", display: "Migraine" },
+            text: "Migraine",
+            aliases: ["ไมเกรน", "ปวดหัวไมเกรน"],
+            i18n: { th: "ไมเกรน" }
+        }
+    },
+    {
+        names: ["back pain", "backache", "pain in back"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "161891005", display: "Backache" },
+            text: "Back pain",
+            aliases: ["ปวดหลัง"],
+            i18n: { th: "ปวดหลัง" }
+        }
+    },
+    {
+        names: ["low back pain", "lower back pain", "lumbar pain"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "279039007", display: "Low back pain" },
+            text: "Low back pain",
+            aliases: ["ปวดหลังส่วนล่าง", "ปวดเอว"],
+            i18n: { th: "ปวดหลังส่วนล่าง" }
+        }
+    },
+    {
+        names: ["joint pain", "arthralgia", "painful joint"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "57676002", display: "Pain of joint" },
+            text: "Joint pain",
+            aliases: ["ปวดข้อ"],
+            i18n: { th: "ปวดข้อ" }
+        }
+    },
+    {
+        names: ["muscle pain", "myalgia"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "68962001", display: "Muscle pain" },
+            text: "Muscle pain",
+            aliases: ["ปวดกล้ามเนื้อ", "เมื่อยกล้ามเนื้อ"],
+            i18n: { th: "ปวดกล้ามเนื้อ" }
+        }
+    },
+    {
+        names: ["ear pain", "earache", "otalgia"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "301354004", display: "Pain of ear" },
+            text: "Ear pain",
+            aliases: ["ปวดหู"],
+            i18n: { th: "ปวดหู" }
+        }
+    },
+    {
+        names: ["sore throat", "throat pain"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "267102003", display: "Sore throat" },
+            text: "Sore throat",
+            aliases: ["เจ็บคอ", "คอเจ็บ"],
+            i18n: { th: "เจ็บคอ" }
+        }
+    },
+    {
+        names: ["chest pain"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "29857009", display: "Chest pain" },
+            text: "Chest pain",
+            aliases: ["เจ็บหน้าอก"],
+            i18n: { th: "เจ็บหน้าอก" }
+        }
+    },
+    {
+        names: ["pelvic pain", "pelvic and perineal pain"],
+        definition: {
+            coding: {
+                system: SNOMED_SYSTEM,
+                code: "274671002",
+                display: "Pelvic and perineal pain"
+            },
+            text: "Pelvic pain",
+            aliases: ["ปวดเชิงกราน", "ปวดท้องน้อย"],
+            i18n: { th: "ปวดเชิงกราน" }
+        }
+    },
+    {
+        names: ["dysmenorrhea", "menstrual cramps", "period cramps", "period pain"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "266599000", display: "Dysmenorrhea" },
+            text: "Menstrual cramps",
+            aliases: ["ปวดประจำเดือน", "ปวดเมนส์"],
+            i18n: { th: "ปวดประจำเดือน" }
+        }
+    },
+    {
+        names: ["cramp", "cramps", "cramping"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "55300003", display: "Cramp" },
+            text: "Cramp",
+            aliases: ["ตะคริว"],
+            i18n: { th: "ตะคริว" }
+        }
+    },
+    {
+        names: ["spasm", "spasms", "muscle spasm"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "45352006", display: "Spasm" },
+            text: "Spasm",
+            aliases: ["เกร็ง", "กล้ามเนื้อเกร็ง"],
+            i18n: { th: "ตะคริวหรือเกร็ง" }
+        }
+    },
+    {
+        names: ["nausea", "queasiness", "queasy"],
         definition: {
             coding: { system: SNOMED_SYSTEM, code: "422587007", display: "Nausea" },
             text: "Nausea",
+            aliases: ["คลื่นไส้"],
             i18n: { th: "คลื่นไส้" }
         }
     },
     {
-        names: ["itch", "itching", "itchy"],
+        names: ["vomiting", "emesis", "throw up", "throwing up"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "422400008", display: "Vomiting" },
+            text: "Vomiting",
+            aliases: ["อาเจียน"],
+            i18n: { th: "อาเจียน" }
+        }
+    },
+    {
+        names: ["n/v", "nausea and vomiting", "vomiting and nausea"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "418363000",
-                display: "Itching of skin"
+                code: "16932000",
+                display: "Nausea and vomiting"
             },
-            text: "Itching",
-            i18n: { th: "คัน" }
+            text: "Nausea and vomiting",
+            aliases: ["คลื่นไส้อาเจียน", "คลื่นไส้และอาเจียน"],
+            i18n: { th: "คลื่นไส้และอาเจียน" }
         }
     },
     {
-        names: ["anxiety", "nervousness"],
+        names: ["diarrhea", "diarrhoea", "loose stool", "loose stools"],
         definition: {
-            coding: { system: SNOMED_SYSTEM, code: "48694002", display: "Anxiety" },
-            text: "Anxiety",
-            i18n: { th: "วิตกกังวล" }
+            coding: { system: SNOMED_SYSTEM, code: "62315008", display: "Diarrhea" },
+            text: "Diarrhea",
+            aliases: ["ท้องเสีย", "ถ่ายเหลว"],
+            i18n: { th: "ท้องเสีย" }
         }
     },
     {
-        names: ["sleep", "sleeping", "insomnia", "sleep issues"],
+        names: ["constipation"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "193462001",
-                display: "Insomnia"
+                code: "14760008",
+                display: "Constipation"
             },
-            text: "Sleep",
-            i18n: { th: "นอนหลับ" }
+            text: "Constipation",
+            aliases: ["ท้องผูก", "ถ่ายไม่ออก"],
+            i18n: { th: "ท้องผูก" }
+        }
+    },
+    {
+        names: ["heartburn"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "16331000", display: "Heartburn" },
+            text: "Heartburn",
+            aliases: ["แสบร้อนกลางอก"],
+            i18n: { th: "แสบร้อนกลางอก" }
+        }
+    },
+    {
+        names: ["abdominal pain", "stomach pain", "stomachache"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "21522001", display: "Abdominal pain" },
+            text: "Abdominal pain",
+            aliases: ["ปวดท้อง"],
+            i18n: { th: "ปวดท้อง" }
         }
     },
     {
-        names: ["sleepiness", "sleepy", "drowsiness", "drowsy"],
+        names: ["abdominal bloating", "bloating", "bloated"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "79519003",
-                display: "Drowsiness"
+                code: "116289008",
+                display: "Abdominal bloating"
             },
-            text: "Sleepiness",
-            i18n: { th: "ง่วงนอน" }
+            text: "Bloating",
+            aliases: ["ท้องอืด"],
+            i18n: { th: "ท้องอืด" }
+        }
+    },
+    {
+        names: ["flatulence", "gas", "gassy"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "249504006", display: "Flatulence" },
+            text: "Gas",
+            aliases: ["มีแก๊สในท้อง", "ลมในท้อง"],
+            i18n: { th: "มีแก๊สในท้อง" }
+        }
+    },
+    {
+        names: ["eye itch", "itchy eye", "itchy eyes", "eye itching", "itching eye", "itching eyes", "itching of eye", "itching of eyes"],
+        definition: {
+            coding: {
+                system: SNOMED_SYSTEM,
+                code: "74776002",
+                display: "Itching of eye"
+            },
+            text: "Eye itching",
+            aliases: ["คันตา", "ตาคัน"],
+            i18n: { th: "คันตา" }
+        }
+    },
+    {
+        names: ["lesion itch", "itchy lesion", "itching lesion", "lesion itching", "itching of lesion", "itching of skin lesion", "skin lesion itch"],
+        definition: {
+            coding: {
+                system: SNOMED_SYSTEM,
+                code: "445329008",
+                display: "Itching of lesion of skin"
+            },
+            text: "Lesion itching",
+            aliases: ["คันรอยโรค", "คันที่รอยโรค"],
+            i18n: { th: "คันที่รอยโรค" }
+        }
+    },
+    {
+        names: ["itch", "itching", "itchy", "wound itch", "itchy wound", "wound itching", "itching wound", "itching of wound"],
+        definition: {
+            coding: {
+                system: SNOMED_SYSTEM,
+                code: "418363000",
+                display: "Itching of skin"
+            },
+            text: "Itching",
+            aliases: ["คัน", "คันแผล", "แผลคัน"],
+            i18n: { th: "คัน" }
         }
     },
     {
@@ -1390,6 +1810,7 @@ const DEFAULT_PRN_REASON_SOURCE = [
         definition: {
             coding: { system: SNOMED_SYSTEM, code: "49727002", display: "Cough" },
             text: "Cough",
+            aliases: ["ไอ"],
             i18n: { th: "ไอ" }
         }
     },
@@ -1398,43 +1819,38 @@ const DEFAULT_PRN_REASON_SOURCE = [
         definition: {
             coding: { system: SNOMED_SYSTEM, code: "386661006", display: "Fever" },
             text: "Fever",
+            aliases: ["ไข้", "ตัวร้อน"],
             i18n: { th: "ไข้" }
         }
     },
     {
-        names: ["spasm", "spasms", "muscle spasm"],
-        definition: {
-            coding: { system: SNOMED_SYSTEM, code: "45352006", display: "Spasm" },
-            text: "Spasm",
-            i18n: { th: "ตะคริวหรือเกร็ง" }
-        }
-    },
-    {
-        names: ["constipation"],
+        names: ["nasal congestion", "congestion", "stuffy nose", "blocked nose"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "14760008",
-                display: "Constipation"
+                code: "68235000",
+                display: "Nasal congestion"
             },
-            text: "Constipation",
-            i18n: { th: "ท้องผูก" }
+            text: "Nasal congestion",
+            aliases: ["คัดจมูก"],
+            i18n: { th: "คัดจมูก" }
         }
     },
     {
-        names: ["irritation", "irritated"],
+        names: ["nasal discharge", "rhinorrhea", "rhinorrhoea", "runny nose", "discharge from nose"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "257553007",
-                display: "Irritation"
+                code: "64531003",
+                display: "Nasal discharge"
             },
-            text: "Irritation",
-            i18n: { th: "ระคายเคือง" }
+            text: "Runny nose",
+            aliases: ["น้ำมูกไหล"],
+            i18n: { th: "น้ำมูกไหล" }
         }
     },
     {
-        names: ["dyspnea", "shortness of breath", "sob", "breathlessness"],
+        names: ["dyspnea", "dyspnoea", "shortness of breath", "sob", "breathlessness", "breathless"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
@@ -1442,225 +1858,362 @@ const DEFAULT_PRN_REASON_SOURCE = [
                 display: "Dyspnea"
             },
             text: "Shortness of breath",
+            aliases: ["เหนื่อย", "หายใจลำบาก", "หอบ"],
             i18n: { th: "เหนื่อยหรือหายใจลำบาก" }
         }
-    }
-];
-exports.DEFAULT_PRN_REASON_ENTRIES = DEFAULT_PRN_REASON_SOURCE.map((source) => {
-    var _a, _b, _c;
-    const canonicalTerm = (_c = (_a = source.definition.text) !== null && _a !== void 0 ? _a : (_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.display) !== null && _c !== void 0 ? _c : source.names[0];
-    return {
-        canonical: normalizePrnReasonKey(canonicalTerm !== null && canonicalTerm !== void 0 ? canonicalTerm : ""),
-        definition: source.definition,
-        terms: [...source.names]
-    };
-});
-exports.DEFAULT_PRN_REASON_DEFINITIONS = (0, object_1.objectFromEntries)(DEFAULT_PRN_REASON_SOURCE.reduce((entries, source) => {
-    for (const name of source.names) {
-        const key = normalizePrnReasonKey(name);
-        if (!key) {
-            continue;
+    },
+    {
+        names: ["wheezing", "wheeze", "wheezy"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "56018004", display: "Wheezing" },
+            text: "Wheeze",
+            aliases: ["หายใจมีเสียงหวีด"],
+            i18n: { th: "หายใจมีเสียงหวีด" }
         }
-        entries.push([key, source.definition]);
-    }
-    if (source.definition.aliases) {
-        for (const alias of source.definition.aliases) {
-            const key = normalizePrnReasonKey(alias);
-            if (!key) {
-                continue;
-            }
-            entries.push([key, source.definition]);
+    },
+    {
+        names: ["sneezing", "sneeze", "sneezes"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "76067001", display: "Sneezing" },
+            text: "Sneezing",
+            aliases: ["จาม"],
+            i18n: { th: "จาม" }
         }
-    }
-    return entries;
-}, []));
-const DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE = [
+    },
     {
-        names: ["with food", "with meals", "with meal", "after food", "after meals"],
+        names: ["allergic rhinitis", "allergy symptoms", "hay fever", "hayfever"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "311504000",
-                display: "With or after food"
+                code: "61582004",
+                display: "Allergic rhinitis"
             },
-            text: "Take with or after food",
-            i18n: { th: "รับประทานพร้อมหรือหลังอาหาร" }
+            text: "Allergic rhinitis",
+            aliases: ["ภูมิแพ้จมูก", "ภูมิแพ้"],
+            i18n: { th: "ภูมิแพ้จมูก" }
         }
     },
     {
-        names: ["before food", "before meals", "before meal", "1 hour before food"],
+        names: ["rash", "skin rash", "skin eruption", "eruption of skin"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "311501008",
-                display: "Half to one hour before food"
+                code: "271807003",
+                display: "Eruption of skin"
             },
-            text: "Take before food",
-            i18n: { th: "รับประทานก่อนอาหาร" }
+            text: "Rash",
+            aliases: ["ผื่น"],
+            i18n: { th: "ผื่น" }
         }
     },
     {
-        names: ["empty stomach", "on empty stomach"],
+        names: ["burning sensation", "burning", "burning pain"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "717154004",
-                display: "Take on an empty stomach (qualifier value)"
+                code: "90673000",
+                display: "Burning sensation"
             },
-            text: "Take on an empty stomach",
-            i18n: { th: "รับประทานขณะท้องว่าง" }
+            text: "Burning sensation",
+            aliases: ["แสบร้อน", "แสบ"],
+            i18n: { th: "แสบร้อน" }
         }
     },
     {
-        names: ["with water", "with plenty of water", "drink water", "with lots of water"],
+        names: ["irritation", "irritated"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "419303009",
-                display: "With plenty of water"
+                code: "257553007",
+                display: "Irritation"
             },
-            text: "Take with plenty of water",
-            i18n: { th: "รับประทานพร้อมน้ำดื่มจำนวนมาก" }
+            text: "Irritation",
+            aliases: ["ระคายเคือง"],
+            i18n: { th: "ระคายเคือง" }
+        }
+    },
+    {
+        names: ["dry eye", "dry eyes"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "162290004", display: "Dry eyes" },
+            text: "Dry eyes",
+            aliases: ["ตาแห้ง"],
+            i18n: { th: "ตาแห้ง" }
         }
     },
     {
-        names: ["dissolve in water", "mix with water", "mix in water"],
+        names: ["red eye", "red eyes"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "703630003", display: "Red eye" },
+            text: "Red eye",
+            aliases: ["ตาแดง"],
+            i18n: { th: "ตาแดง" }
+        }
+    },
+    {
+        names: ["eye pain", "pain in eye", "ocular pain"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "41652007", display: "Pain in eye" },
+            text: "Eye pain",
+            aliases: ["ปวดตา", "เจ็บตา"],
+            i18n: { th: "ปวดตา" }
+        }
+    },
+    {
+        names: ["dry skin", "xeroderma"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "52475004", display: "Xeroderma" },
+            text: "Dry skin",
+            aliases: ["ผิวแห้ง"],
+            i18n: { th: "ผิวแห้ง" }
+        }
+    },
+    {
+        names: ["dysuria", "burning urination", "burning when urinating"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "49650001", display: "Dysuria" },
+            text: "Dysuria",
+            aliases: ["แสบขัด", "ปัสสาวะแสบขัด", "แสบเวลาปัสสาวะ"],
+            i18n: { th: "แสบขัดเวลาปัสสาวะ" }
+        }
+    },
+    {
+        names: ["frequency of urination", "urinary frequency", "frequent urination"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "417995008",
-                display: "Dissolve or mix with water before taking"
+                code: "364198000",
+                display: "Frequency of urination"
             },
-            text: "Dissolve or mix with water before taking",
-            i18n: { th: "ละลายหรือผสมน้ำก่อนรับประทาน" }
+            text: "Urinary frequency",
+            aliases: ["ปัสสาวะบ่อย"],
+            i18n: { th: "ปัสสาวะบ่อย" }
         }
     },
     {
-        names: ["avoid alcohol", "no alcohol", "no alc", "avoid alcoholic drink"],
+        names: ["urgent desire to urinate", "urinary urgency", "urgency to urinate", "urgency to pass urine", "urgency of micturition"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "419822006",
-                display: "Warning. Avoid alcoholic drink (qualifier value)"
+                code: "75088002",
+                display: "Urgent desire to urinate"
             },
-            text: "Avoid alcoholic drinks",
-            i18n: { th: "หลีกเลี่ยงเครื่องดื่มแอลกอฮอล์" }
+            text: "Urinary urgency",
+            aliases: ["ปวดปัสสาวะรีบ", "ปวดปัสสาวะกะทันหัน"],
+            i18n: { th: "ปวดปัสสาวะรีบ" }
         }
     },
     {
-        names: ["may cause drowsiness", "do not drive", "avoid driving", "no driving", "no drive"],
+        names: ["vaginal discharge", "discharge from vagina"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "418954008",
-                display: "Warning. May cause drowsiness. If affected do not drive or operate machinery (qualifier value)"
+                code: "271939006",
+                display: "Vaginal discharge"
             },
-            text: "May cause drowsiness; do not drive if affected",
-            i18n: { th: "อาจทำให้ง่วงซึม; ห้ามขับขี่ยานพาหนะหรือทำงานกับเครื่องจักรหากมีอาการ" }
+            text: "Vaginal discharge",
+            aliases: ["ตกขาว"],
+            i18n: { th: "ตกขาว" }
         }
     },
     {
-        names: [
-            "drowsiness avoid alcohol",
-            "may cause drowsiness avoid alcohol",
-            "do not drive avoid alcohol",
-            "drowsy avoid alc",
-            "drowsy avoid drive",
-            "drowsy avoid driving",
-            "drowsy no drive",
-            "drowsy no driving",
-            "drowsy no alc"
-        ],
+        names: ["vaginal irritation", "irritation of vagina"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "418914006",
-                display: "Warning. May cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink (qualifier value)"
+                code: "161816004",
+                display: "Vaginal irritation"
             },
-            text: "May cause drowsiness; avoid driving or alcohol",
-            i18n: { th: "อาจทำให้ง่วงซึม; หลีกเลี่ยงการขับขี่ยานพาหนะหรือดื่มแอลกอฮอล์" }
+            text: "Vaginal irritation",
+            aliases: ["ระคายเคืองช่องคลอด"],
+            i18n: { th: "ระคายเคืองช่องคลอด" }
         }
     },
     {
-        names: [
-            "drowsiness next day",
-            "drowsiness next day avoid alcohol",
-            "may cause drowsiness next day",
-            "may next day drowsy",
-            "may drowsy next day"
-        ],
+        names: ["pruritus of vagina", "itching of vagina", "vaginal itching", "vaginal itch"],
+        definition: {
+            coding: {
+                system: SNOMED_SYSTEM,
+                code: "34363003",
+                display: "Pruritus of vagina"
+            },
+            text: "Vaginal itching",
+            aliases: ["คันช่องคลอด"],
+            i18n: { th: "คันช่องคลอด" }
+        }
+    },
+    {
+        names: ["anxiety", "nervousness", "feeling anxious"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "48694002", display: "Anxiety" },
+            text: "Anxiety",
+            aliases: ["วิตกกังวล", "กังวล"],
+            i18n: { th: "วิตกกังวล" }
+        }
+    },
+    {
+        names: ["panic attack", "panic", "panic episode"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "225624000", display: "Panic attack" },
+            text: "Panic attack",
+            aliases: ["อาการแพนิค", "แพนิค", "ตื่นตระหนก"],
+            i18n: { th: "อาการแพนิค" }
+        }
+    },
+    {
+        names: ["agitation", "agitated", "feeling agitated", "unable to keep still"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "418071006",
-                display: "Warning. Causes drowsiness which may continue the next day. If affected do not drive or operate machinery. Avoid alcoholic drink (qualifier value)"
+                code: "24199005",
+                display: "Feeling agitated"
             },
-            text: "May cause next-day drowsiness; avoid driving or alcohol",
-            i18n: { th: "อาจทำให้ง่วงซึมในวันถัดมา; หลีกเลี่ยงการขับขี่ยานพาหนะหรือดื่มแอลกอฮอล์" }
+            text: "Agitation",
+            aliases: ["กระสับกระส่าย", "อยู่ไม่นิ่ง"],
+            i18n: { th: "กระสับกระส่าย" }
         }
     },
     {
-        names: ["avoid sun", "avoid sunlight", "avoid sun lamps"],
+        names: ["sleep", "sleeping", "insomnia", "sleep issues", "unable to sleep"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "418521000",
-                display: "Avoid exposure of skin to direct sunlight or sun lamps (qualifier value)"
+                code: "193462001",
+                display: "Insomnia"
             },
-            text: "Avoid sunlight or sun lamps",
-            i18n: { th: "หลีกเลี่ยงแสงแดดหรือหลอดไฟแสงยูวี" }
+            text: "Sleep",
+            aliases: ["นอนหลับ", "นอนไม่หลับ"],
+            i18n: { th: "นอนหลับ" }
+        }
+    },
+    {
+        names: ["sleepiness", "sleepy", "drowsiness", "drowsy", "somnolence"],
+        definition: {
+            coding: {
+                system: SNOMED_SYSTEM,
+                code: "79519003",
+                display: "Drowsiness"
+            },
+            text: "Sleepiness",
+            aliases: ["ง่วงนอน", "ง่วง"],
+            i18n: { th: "ง่วงนอน" }
+        }
+    },
+    {
+        names: ["dizziness", "giddiness"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "404640003", display: "Dizziness" },
+            text: "Dizziness",
+            aliases: ["เวียนหัว", "เวียนศีรษะ"],
+            i18n: { th: "เวียนศีรษะ" }
+        }
+    },
+    {
+        names: ["vertigo"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "399153001", display: "Vertigo" },
+            text: "Vertigo",
+            aliases: ["บ้านหมุน"],
+            i18n: { th: "บ้านหมุน" }
         }
     },
     {
-        names: ["swallow whole", "do not chew", "do not crush", "do not crush or chew", "no chewing"],
+        names: ["hallucinations", "hallucination"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "7011001", display: "Hallucinations" },
+            text: "Hallucinations",
+            aliases: ["ประสาทหลอน", "หูแว่ว", "เห็นภาพหลอน"],
+            i18n: { th: "ประสาทหลอน" }
+        }
+    },
+    {
+        names: ["mania", "manic"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "231494001", display: "Mania" },
+            text: "Mania",
+            aliases: ["แมเนีย", "อารมณ์คึกผิดปกติ"],
+            i18n: { th: "แมเนีย" }
+        }
+    },
+    {
+        names: ["depressed mood", "feeling depressed", "depressed"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "418693002",
-                display: "Swallowed whole, not chewed (qualifier value)"
+                code: "366979004",
+                display: "Depressed mood"
             },
-            text: "Swallow whole; do not crush or chew",
-            i18n: { th: "กลืนทั้งเม็ด; ห้ามเคี้ยวหรือบด" }
+            text: "Depressed mood",
+            aliases: ["อารมณ์ซึมเศร้า", "ซึมเศร้า"],
+            i18n: { th: "อารมณ์ซึมเศร้า" }
         }
     },
     {
-        names: ["chew", "chewed", "sucked or chewed", "please chew", "must chew"],
+        names: ["poor concentration", "difficulty concentrating", "unable to concentrate", "cannot concentrate", "can't focus"],
         definition: {
             coding: {
                 system: SNOMED_SYSTEM,
-                code: "418991002",
-                display: "Sucked or chewed (qualifier value)"
+                code: "26329005",
+                display: "Poor concentration"
             },
-            text: "Suck or chew before swallowing",
-            i18n: { th: "เคี้ยวหรืออมให้ละลายก่อนกลืน" }
+            text: "Poor concentration",
+            aliases: ["สมาธิไม่ดี", "ขาดสมาธิ", "ไม่มีสมาธิ"],
+            i18n: { th: "สมาธิไม่ดี" }
+        }
+    },
+    {
+        names: ["palpitations", "palpitation"],
+        definition: {
+            coding: { system: SNOMED_SYSTEM, code: "80313002", display: "Palpitations" },
+            text: "Palpitations",
+            aliases: ["ใจสั่น"],
+            i18n: { th: "ใจสั่น" }
         }
     }
 ];
-exports.DEFAULT_ADDITIONAL_INSTRUCTION_ENTRIES = DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE.map((source) => {
+exports.DEFAULT_PRN_REASON_ENTRIES = DEFAULT_PRN_REASON_SOURCE.map((source) => {
     var _a, _b, _c;
     const canonicalTerm = (_c = (_a = source.definition.text) !== null && _a !== void 0 ? _a : (_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.display) !== null && _c !== void 0 ? _c : source.names[0];
+    const terms = [];
+    const seen = new Set();
+    const pushTerm = (value) => {
+        if (!value) {
+            return;
+        }
+        const key = normalizePrnReasonKey(value);
+        if (!key || seen.has(key)) {
+            return;
+        }
+        seen.add(key);
+        terms.push(value);
+    };
+    for (const name of source.names) {
+        pushTerm(name);
+    }
+    if (source.definition.aliases) {
+        for (const alias of source.definition.aliases) {
+            pushTerm(alias);
+        }
+    }
+    if (source.definition.i18n) {
+        for (const locale in source.definition.i18n) {
+            const translation = source.definition.i18n[locale];
+            pushTerm(translation);
+        }
+    }
     return {
-        canonical: normalizeAdditionalInstructionKey(canonicalTerm !== null && canonicalTerm !== void 0 ? canonicalTerm : ""),
+        canonical: normalizePrnReasonKey(canonicalTerm !== null && canonicalTerm !== void 0 ? canonicalTerm : ""),
         definition: source.definition,
-        terms: [...source.names]
+        terms
     };
 });
-exports.DEFAULT_ADDITIONAL_INSTRUCTION_DEFINITIONS = (0, object_1.objectFromEntries)(DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE.reduce((entries, source) => {
-    for (const name of source.names) {
-        const key = normalizeAdditionalInstructionKey(name);
+exports.DEFAULT_PRN_REASON_DEFINITIONS = (0, object_1.objectFromEntries)(exports.DEFAULT_PRN_REASON_ENTRIES.reduce((entries, entry) => {
+    for (const term of entry.terms) {
+        const key = normalizePrnReasonKey(term);
         if (!key) {
             continue;
         }
-        entries.push([key, source.definition]);
-    }
-    if (source.definition.aliases) {
-        for (const alias of source.definition.aliases) {
-            const key = normalizeAdditionalInstructionKey(alias);
-            if (!key) {
-                continue;
-            }
-            entries.push([key, source.definition]);
-        }
+        entries.push([key, entry.definition]);
     }
     return entries;
 }, []));
@@ -1671,10 +2224,3 @@ function findPrnReasonDefinitionByCoding(system, code) {
     var _a;
     return (_a = DEFAULT_PRN_REASON_SOURCE.find((source) => { var _a, _b; return ((_a = source.definition.coding) === null || _a === void 0 ? void 0 : _a.system) === system && ((_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.code) === code; })) === null || _a === void 0 ? void 0 : _a.definition;
 }
-/**
- * Finds a default additional instruction definition by its SNOMED coding.
- */
-function findAdditionalInstructionDefinitionByCoding(system, code) {
-    var _a;
-    return (_a = DEFAULT_ADDITIONAL_INSTRUCTION_SOURCE.find((source) => { var _a, _b; return ((_a = source.definition.coding) === null || _a === void 0 ? void 0 : _a.system) === system && ((_b = source.definition.coding) === null || _b === void 0 ? void 0 : _b.code) === code; })) === null || _a === void 0 ? void 0 : _a.definition;
-}