clinicaltrialsgov-mcp-server 2.5.5 → 2.6.0

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Files changed (21) hide show
  1. package/README.md +1 -1
  2. package/dist/mcp-server/tools/definitions/get-study-count.tool.d.ts +8 -0
  3. package/dist/mcp-server/tools/definitions/get-study-count.tool.d.ts.map +1 -1
  4. package/dist/mcp-server/tools/definitions/get-study-count.tool.js +27 -0
  5. package/dist/mcp-server/tools/definitions/get-study-count.tool.js.map +1 -1
  6. package/dist/mcp-server/tools/definitions/get-study-results.tool.d.ts.map +1 -1
  7. package/dist/mcp-server/tools/definitions/get-study-results.tool.js +49 -12
  8. package/dist/mcp-server/tools/definitions/get-study-results.tool.js.map +1 -1
  9. package/dist/mcp-server/tools/definitions/get-study.tool.d.ts +7 -0
  10. package/dist/mcp-server/tools/definitions/get-study.tool.d.ts.map +1 -1
  11. package/dist/mcp-server/tools/definitions/get-study.tool.js +68 -14
  12. package/dist/mcp-server/tools/definitions/get-study.tool.js.map +1 -1
  13. package/dist/mcp-server/tools/definitions/search-studies.tool.d.ts +5 -0
  14. package/dist/mcp-server/tools/definitions/search-studies.tool.d.ts.map +1 -1
  15. package/dist/mcp-server/tools/definitions/search-studies.tool.js +42 -29
  16. package/dist/mcp-server/tools/definitions/search-studies.tool.js.map +1 -1
  17. package/dist/mcp-server/tools/utils/recovery-hints.d.ts +1 -0
  18. package/dist/mcp-server/tools/utils/recovery-hints.d.ts.map +1 -1
  19. package/dist/mcp-server/tools/utils/recovery-hints.js +1 -0
  20. package/dist/mcp-server/tools/utils/recovery-hints.js.map +1 -1
  21. package/package.json +1 -1
package/README.md CHANGED
@@ -7,7 +7,7 @@
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  <div align="center">
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- [![npm](https://img.shields.io/npm/v/clinicaltrialsgov-mcp-server?style=flat-square&logo=npm&logoColor=white)](https://www.npmjs.com/package/clinicaltrialsgov-mcp-server) [![Docker](https://img.shields.io/badge/Docker-ghcr.io-2496ED?style=flat-square&logo=docker&logoColor=white)](https://github.com/users/cyanheads/packages/container/package/clinicaltrialsgov-mcp-server) [![Version](https://img.shields.io/badge/Version-2.5.5-blue.svg?style=flat-square)](./CHANGELOG.md) [![MCP SDK](https://img.shields.io/badge/MCP%20SDK-^1.29.0-green.svg?style=flat-square)](https://modelcontextprotocol.io/) [![License](https://img.shields.io/badge/License-Apache%202.0-orange.svg?style=flat-square)](./LICENSE) [![TypeScript](https://img.shields.io/badge/TypeScript-^6.0-3178C6.svg?style=flat-square)](https://www.typescriptlang.org/) [![Bun](https://img.shields.io/badge/Bun-v1.3.2-blueviolet.svg?style=flat-square)](https://bun.sh/)
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+ [![npm](https://img.shields.io/npm/v/clinicaltrialsgov-mcp-server?style=flat-square&logo=npm&logoColor=white)](https://www.npmjs.com/package/clinicaltrialsgov-mcp-server) [![Docker](https://img.shields.io/badge/Docker-ghcr.io-2496ED?style=flat-square&logo=docker&logoColor=white)](https://github.com/users/cyanheads/packages/container/package/clinicaltrialsgov-mcp-server) [![Version](https://img.shields.io/badge/Version-2.6.0-blue.svg?style=flat-square)](./CHANGELOG.md) [![MCP SDK](https://img.shields.io/badge/MCP%20SDK-^1.29.0-green.svg?style=flat-square)](https://modelcontextprotocol.io/) [![License](https://img.shields.io/badge/License-Apache%202.0-orange.svg?style=flat-square)](./LICENSE) [![TypeScript](https://img.shields.io/badge/TypeScript-^6.0-3178C6.svg?style=flat-square)](https://www.typescriptlang.org/) [![Bun](https://img.shields.io/badge/Bun-v1.3.2-blueviolet.svg?style=flat-square)](https://bun.sh/)
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  </div>
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package/dist/mcp-server/tools/definitions/get-study-count.tool.d.ts CHANGED
@@ -8,7 +8,10 @@ export declare const getStudyCount: import("@cyanheads/mcp-ts-core").ToolDefinit
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  query: z.ZodOptional<z.ZodString>;
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  conditionQuery: z.ZodOptional<z.ZodString>;
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  interventionQuery: z.ZodOptional<z.ZodString>;
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+ locationQuery: z.ZodOptional<z.ZodString>;
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  sponsorQuery: z.ZodOptional<z.ZodString>;
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+ titleQuery: z.ZodOptional<z.ZodString>;
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+ outcomeQuery: z.ZodOptional<z.ZodString>;
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  statusFilter: z.ZodOptional<z.ZodUnion<readonly [z.ZodString, z.ZodArray<z.ZodString>]>>;
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  phaseFilter: z.ZodOptional<z.ZodUnion<readonly [z.ZodString, z.ZodArray<z.ZodString>]>>;
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  advancedFilter: z.ZodOptional<z.ZodString>;
@@ -20,6 +23,11 @@ export declare const getStudyCount: import("@cyanheads/mcp-ts-core").ToolDefinit
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  readonly code: JsonRpcErrorCode.ValidationError;
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  readonly when: "A field name in the advanced filter or AREA[] expression is invalid (often a module name instead of a piece name).";
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  readonly recovery: "Call clinicaltrials_get_field_definitions to browse the field tree; use PascalCase piece names like OverallStatus, Phase, or StudyType.";
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+ }, {
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+ readonly reason: "enum_invalid";
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+ readonly code: JsonRpcErrorCode.ValidationError;
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+ readonly when: "statusFilter or phaseFilter contains a value ClinicalTrials.gov does not accept.";
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+ readonly recovery: "Call clinicaltrials_get_field_values with fields=[\"OverallStatus\"] or fields=[\"Phase\"] to see the valid enum values the filter accepts.";
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  }, {
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  readonly reason: "query_parse_error";
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  readonly code: JsonRpcErrorCode.ValidationError;
package/dist/mcp-server/tools/definitions/get-study-count.tool.d.ts.map CHANGED
@@ -1 +1 @@
1
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+ {"version":3,"file":"get-study-count.tool.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/definitions/get-study-count.tool.ts"],"names":[],"mappings":"AAAA;;;GAGG;AAEH,OAAO,EAAQ,CAAC,EAAE,MAAM,wBAAwB,CAAC;AACjD,OAAO,EAAE,gBAAgB,EAAE,MAAM,+BAA+B,CAAC;AAKjE,eAAO,MAAM,aAAa;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;EAsLxB,CAAC"}
package/dist/mcp-server/tools/definitions/get-study-count.tool.js CHANGED
@@ -21,6 +21,12 @@ export const getStudyCount = tool('clinicaltrials_get_study_count', {
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  when: 'A field name in the advanced filter or AREA[] expression is invalid (often a module name instead of a piece name).',
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  recovery: RECOVERY_HINTS.field_invalid,
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  },
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+ {
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+ reason: 'enum_invalid',
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+ code: JsonRpcErrorCode.ValidationError,
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+ when: 'statusFilter or phaseFilter contains a value ClinicalTrials.gov does not accept.',
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+ recovery: RECOVERY_HINTS.enum_invalid,
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+ },
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  {
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  reason: 'query_parse_error',
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  code: JsonRpcErrorCode.ValidationError,
@@ -48,10 +54,22 @@ export const getStudyCount = tool('clinicaltrials_get_study_count', {
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  .string()
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  .optional()
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  .describe('Intervention/treatment search. E.g., "pembrolizumab", "cognitive behavioral therapy". Plain words plus AND/OR/NOT only — reserved chars: [ ] ( ) ,'),
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+ locationQuery: z
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+ .string()
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+ .optional()
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+ .describe('Location search — city, state, country, or facility name. Plain words plus AND/OR/NOT only — reserved chars: [ ] ( ) ,'),
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  sponsorQuery: z
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  .string()
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  .optional()
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  .describe('Sponsor/collaborator name search. Plain words plus AND/OR/NOT only — reserved chars: [ ] ( ) ,'),
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+ titleQuery: z
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+ .string()
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+ .optional()
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+ .describe('Search within study titles and acronyms only. Plain words plus AND/OR/NOT only — reserved chars: [ ] ( ) ,'),
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+ outcomeQuery: z
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+ .string()
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+ .optional()
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+ .describe('Search within outcome measure fields. Plain words plus AND/OR/NOT only — reserved chars: [ ] ( ) ,'),
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  statusFilter: z
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  .union([
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  z.string().describe('A single status value.'),
@@ -105,7 +123,10 @@ export const getStudyCount = tool('clinicaltrials_get_study_count', {
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  queryTerm: input.query,
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  queryCond: input.conditionQuery,
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  queryIntr: input.interventionQuery,
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+ queryLocn: input.locationQuery,
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  querySpons: input.sponsorQuery,
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+ queryTitles: input.titleQuery,
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+ queryOutc: input.outcomeQuery,
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  filterOverallStatus: toArray(input.statusFilter),
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  filterAdvanced: buildAdvancedFilter(toArray(input.phaseFilter), input.advancedFilter),
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  countTotal: true,
@@ -121,8 +142,14 @@ export const getStudyCount = tool('clinicaltrials_get_study_count', {
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  criteria.conditionQuery = input.conditionQuery;
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  if (input.interventionQuery)
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  criteria.interventionQuery = input.interventionQuery;
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+ if (input.locationQuery)
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+ criteria.locationQuery = input.locationQuery;
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  if (input.sponsorQuery)
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  criteria.sponsorQuery = input.sponsorQuery;
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+ if (input.titleQuery)
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+ criteria.titleQuery = input.titleQuery;
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+ if (input.outcomeQuery)
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+ criteria.outcomeQuery = input.outcomeQuery;
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  if (input.statusFilter)
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  criteria.statusFilter = input.statusFilter;
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  if (input.phaseFilter)
package/dist/mcp-server/tools/definitions/get-study-count.tool.js.map CHANGED
@@ -1 +1 @@
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1
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package/dist/mcp-server/tools/definitions/get-study-results.tool.d.ts.map CHANGED
@@ -1 +1 @@
1
- {"version":3,"file":"get-study-results.tool.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/definitions/get-study-results.tool.ts"],"names":[],"mappings":"AAAA;;;GAGG;AAEH,OAAO,EAAQ,CAAC,EAAE,MAAM,wBAAwB,CAAC;AACjD,OAAO,EAAE,gBAAgB,EAAE,MAAM,+BAA+B,CAAC;AAwVjE,eAAO,MAAM,eAAe;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;cA2O1B,CAAC"}
1
+ {"version":3,"file":"get-study-results.tool.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/definitions/get-study-results.tool.ts"],"names":[],"mappings":"AAAA;;;GAGG;AAEH,OAAO,EAAQ,CAAC,EAAE,MAAM,wBAAwB,CAAC;AACjD,OAAO,EAAE,gBAAgB,EAAE,MAAM,+BAA+B,CAAC;AA+YjE,eAAO,MAAM,eAAe;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;cA2O1B,CAAC"}
package/dist/mcp-server/tools/definitions/get-study-results.tool.js CHANGED
@@ -88,14 +88,47 @@ function summarizeOutcome(o) {
88
88
  ...(topAnalysis ? { topAnalysis } : {}),
89
89
  };
90
90
  }
91
- /** Condense the adverse events module to counts. */
91
+ const TOP_EVENTS_LIMIT = 20;
92
+ /** Sum an adverse event's per-group stats into trial-wide affected/at-risk totals. */
93
+ function aggregateEventStats(ev) {
94
+ const stats = ev.stats ?? [];
95
+ let numAffected = 0;
96
+ let numAtRisk = 0;
97
+ for (const s of stats) {
98
+ numAffected += Number(s.numAffected) || 0;
99
+ numAtRisk += Number(s.numAtRisk) || 0;
100
+ }
101
+ return { numAffected, numAtRisk };
102
+ }
103
+ /**
104
+ * Rank the most frequent adverse events across serious and other groups,
105
+ * aggregating each term's affected/at-risk counts across all arms. Trial-wide
106
+ * incidence view for summary mode — "which AEs and how common" in ~5KB rather
107
+ * than the full ~450KB nested structure.
108
+ */
109
+ function topAdverseEvents(ae) {
110
+ const collect = (events, kind) => Array.isArray(events)
111
+ ? events.map((ev) => ({
112
+ term: ev.term ?? 'Unspecified',
113
+ organSystem: ev.organSystem ?? '',
114
+ kind,
115
+ ...aggregateEventStats(ev),
116
+ }))
117
+ : [];
118
+ return [...collect(ae.seriousEvents, 'serious'), ...collect(ae.otherEvents, 'other')]
119
+ .sort((a, b) => b.numAffected - a.numAffected)
120
+ .slice(0, TOP_EVENTS_LIMIT);
121
+ }
122
+ /** Condense the adverse events module to counts plus a ranked top-events view. */
92
123
  function summarizeAdverseEvents(ae) {
93
124
  const events = ae.eventGroups;
125
+ const topEvents = topAdverseEvents(ae);
94
126
  return {
95
127
  timeFrame: ae.timeFrame,
96
128
  groupCount: Array.isArray(events) ? events.length : undefined,
97
129
  seriousEventCount: Array.isArray(ae.seriousEvents) ? ae.seriousEvents.length : undefined,
98
130
  otherEventCount: Array.isArray(ae.otherEvents) ? ae.otherEvents.length : undefined,
131
+ ...(topEvents.length > 0 ? { topEvents } : {}),
99
132
  };
100
133
  }
101
134
  /** Condense participant flow to period/group counts. */
@@ -191,7 +224,7 @@ function formatAdverseEvents(ae, lines) {
191
224
  lines.push(`Assessment period: ${timeFrame}`);
192
225
  const serious = ae.seriousEvents;
193
226
  const other = ae.otherEvents;
194
- // Summary shape — only counts, no event arrays
227
+ // Summary shape — counts plus the ranked top-events view, no raw event arrays
195
228
  if (!serious && !other) {
196
229
  const parts = [
197
230
  gm.size ? `${gm.size} groups` : '',
@@ -200,12 +233,22 @@ function formatAdverseEvents(ae, lines) {
200
233
  ].filter(Boolean);
201
234
  if (parts.length)
202
235
  lines.push(parts.join(' | '));
236
+ const topEvents = ae.topEvents;
237
+ if (topEvents?.length) {
238
+ lines.push(`\n**Most frequent events** (top ${topEvents.length} by participants affected)`);
239
+ for (const ev of topEvents) {
240
+ const sys = ev.organSystem ? ` _(${ev.organSystem})_` : '';
241
+ lines.push(`- ${ev.term}${sys} — ${ev.numAffected}/${ev.numAtRisk} affected [${ev.kind}]`);
242
+ }
243
+ }
203
244
  return;
204
245
  }
205
246
  // Full shape — render actual events with per-group stats
247
+ // Render every event the handler returned — payload control is summary mode
248
+ // (which condenses per item), never a format()-side row cap (channel parity).
206
249
  const renderEvents = (label, events) => {
207
250
  lines.push(`\n**${label}** (${events.length})`);
208
- for (const ev of events.slice(0, 20)) {
251
+ for (const ev of events) {
209
252
  const stats = ev.stats;
210
253
  const statStr = (stats ?? [])
211
254
  .map((s) => {
@@ -215,8 +258,6 @@ function formatAdverseEvents(ae, lines) {
215
258
  .join(', ');
216
259
  lines.push(`- ${ev.term}${statStr ? ` — ${statStr}` : ''}`);
217
260
  }
218
- if (events.length > 20)
219
- lines.push(` ... and ${events.length - 20} more`);
220
261
  };
221
262
  if (serious?.length)
222
263
  renderEvents('Serious Events', serious);
@@ -278,18 +319,16 @@ function formatBaseline(bl, lines) {
278
319
  !firstMeasure.classes?.length) {
279
320
  if (gm.size)
280
321
  lines.push(`${gm.size} groups`);
281
- for (const m of measures.slice(0, 10)) {
322
+ for (const m of measures) {
282
323
  const unit = m.unitOfMeasure ? ` (${m.unitOfMeasure})` : '';
283
324
  lines.push(`- ${m.title ?? 'Measure'}${unit}`);
284
325
  }
285
- if (measures.length > 10)
286
- lines.push(`... and ${measures.length - 10} more`);
287
326
  return;
288
327
  }
289
328
  // Full shape — render per-group values
290
329
  if (gm.size)
291
330
  lines.push(`Groups: ${[...gm.values()].map((g) => shortGroup(g)).join(', ')}`);
292
- for (const m of (measures ?? []).slice(0, 15)) {
331
+ for (const m of measures ?? []) {
293
332
  const title = m.title ?? 'Measure';
294
333
  const unit = m.unitOfMeasure ? ` (${m.unitOfMeasure})` : '';
295
334
  const paramType = m.paramType ?? '';
@@ -317,8 +356,6 @@ function formatBaseline(bl, lines) {
317
356
  }
318
357
  }
319
358
  }
320
- if ((measures ?? []).length > 15)
321
- lines.push(`... and ${(measures ?? []).length - 15} more`);
322
359
  }
323
360
  export const getStudyResults = tool('clinicaltrials_get_study_results', {
324
361
  description: `Fetch clinical trial results data from ClinicalTrials.gov for completed studies — outcome measures with statistics, adverse events, participant flow, and baseline characteristics. Only available for studies where hasResults is true. Use clinicaltrials_search_studies first to find studies with results.`,
@@ -375,7 +412,7 @@ export const getStudyResults = tool('clinicaltrials_get_study_results', {
375
412
  adverseEvents: z
376
413
  .record(z.string(), z.unknown())
377
414
  .optional()
378
- .describe('Adverse events. Summary mode: timeFrame, groupCount, seriousEventCount, otherEventCount. Full mode: adds eventGroups, seriousEvents, otherEvents with per-event term and per-group affected/at-risk stats.'),
415
+ .describe('Adverse events. Summary mode: timeFrame, groupCount, seriousEventCount, otherEventCount, plus topEvents — the most frequent events ranked by participants affected, aggregated across arms (term, organSystem, kind, numAffected, numAtRisk). Full mode: adds eventGroups, seriousEvents, otherEvents with per-event term and per-group affected/at-risk stats.'),
379
416
  participantFlow: z
380
417
  .record(z.string(), z.unknown())
381
418
  .optional()
package/dist/mcp-server/tools/definitions/get-study-results.tool.js.map CHANGED
@@ -1 +1 @@
1
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package/dist/mcp-server/tools/definitions/get-study.tool.d.ts CHANGED
@@ -29,6 +29,13 @@ export declare const getStudy: import("@cyanheads/mcp-ts-core").ToolDefinition<z
29
29
  radiusMi: z.ZodNumber;
30
30
  }, z.core.$strip>>;
31
31
  }, z.core.$strip>;
32
+ resultsSummary: z.ZodOptional<z.ZodObject<{
33
+ outcomeMeasures: z.ZodOptional<z.ZodNumber>;
34
+ seriousAdverseEvents: z.ZodOptional<z.ZodNumber>;
35
+ otherAdverseEvents: z.ZodOptional<z.ZodNumber>;
36
+ participantFlowPeriods: z.ZodOptional<z.ZodNumber>;
37
+ baselineMeasures: z.ZodOptional<z.ZodNumber>;
38
+ }, z.core.$strip>>;
32
39
  }, z.core.$strip>, readonly [{
33
40
  readonly reason: "study_not_found";
34
41
  readonly code: JsonRpcErrorCode.NotFound;
package/dist/mcp-server/tools/definitions/get-study.tool.d.ts.map CHANGED
@@ -1 +1 @@
1
- {"version":3,"file":"get-study.tool.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/definitions/get-study.tool.ts"],"names":[],"mappings":"AAAA;;;;GAIG;AAEH,OAAO,EAAQ,CAAC,EAAE,MAAM,wBAAwB,CAAC;AACjD,OAAO,EAAE,gBAAgB,EAAE,MAAM,+BAA+B,CAAC;AAkGjE,eAAO,MAAM,QAAQ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;cAocnB,CAAC"}
1
+ {"version":3,"file":"get-study.tool.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/definitions/get-study.tool.ts"],"names":[],"mappings":"AAAA;;;;GAIG;AAEH,OAAO,EAAQ,CAAC,EAAE,MAAM,wBAAwB,CAAC;AACjD,OAAO,EAAE,gBAAgB,EAAE,MAAM,+BAA+B,CAAC;AAiIjE,eAAO,MAAM,QAAQ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;cAkenB,CAAC"}
package/dist/mcp-server/tools/definitions/get-study.tool.js CHANGED
@@ -71,6 +71,32 @@ function applyFilters(study, input) {
71
71
  }
72
72
  return { study: { ...study, protocolSection: nextPs }, meta };
73
73
  }
74
+ /**
75
+ * Compact counts of a study's posted results, computed before the heavy
76
+ * resultsSection is dropped from this record-level tool's payload. Returns
77
+ * undefined when the study has no posted results.
78
+ */
79
+ function summarizeResults(study) {
80
+ if (!study.hasResults || !study.resultsSection)
81
+ return;
82
+ const rs = study.resultsSection;
83
+ const om = rs.outcomeMeasuresModule;
84
+ const ae = rs.adverseEventsModule;
85
+ const pf = rs.participantFlowModule;
86
+ const bl = rs.baselineCharacteristicsModule;
87
+ const summary = {};
88
+ if (om?.outcomeMeasures?.length)
89
+ summary.outcomeMeasures = om.outcomeMeasures.length;
90
+ if (ae?.seriousEvents?.length)
91
+ summary.seriousAdverseEvents = ae.seriousEvents.length;
92
+ if (ae?.otherEvents?.length)
93
+ summary.otherAdverseEvents = ae.otherEvents.length;
94
+ if (pf?.periods?.length)
95
+ summary.participantFlowPeriods = pf.periods.length;
96
+ if (bl?.measures?.length)
97
+ summary.baselineMeasures = bl.measures.length;
98
+ return Object.keys(summary).length > 0 ? summary : undefined;
99
+ }
74
100
  export const getStudy = tool('clinicaltrials_get_study_record', {
75
101
  description: 'Fetch a single clinical trial study by NCT ID from ClinicalTrials.gov. Returns the full study record including protocol details, eligibility criteria, outcomes, arms, interventions, contacts, and locations. Optional locationLimit / outcomeLimit / nearLocation parameters trim locations and outcomes — original totals are preserved in `filtersApplied` whenever a cap is applied.',
76
102
  annotations: {
@@ -121,7 +147,7 @@ export const getStudy = tool('clinicaltrials_get_study_record', {
121
147
  output: z.object({
122
148
  study: z
123
149
  .record(z.string(), z.unknown())
124
- .describe('Full study record with caller-requested filters already applied to locations and outcomes. Top-level keys: protocolSection (identification, status, sponsor, conditions, design, arms/interventions, outcomes, eligibility, contacts/locations), derivedSection (MeSH-normalized terms), hasResults, resultsSection, documentSection. Use clinicaltrials_get_field_definitions to explore the schema.'),
150
+ .describe('Full study record with caller-requested filters already applied to locations and outcomes. Top-level keys: protocolSection (identification, status, sponsor, conditions, design, arms/interventions, outcomes, eligibility, contacts/locations), derivedSection (MeSH-normalized terms), hasResults, documentSection. The heavy resultsSection is omitted — see resultsSummary for counts and clinicaltrials_get_study_results for full results data. Use clinicaltrials_get_field_definitions to explore the schema.'),
125
151
  filtersApplied: z
126
152
  .object({
127
153
  totalLocations: z
@@ -156,11 +182,36 @@ export const getStudy = tool('clinicaltrials_get_study_record', {
156
182
  .describe('Echo of the nearLocation input.'),
157
183
  })
158
184
  .describe('Metadata about the filtering applied to `study`.'),
185
+ resultsSummary: z
186
+ .object({
187
+ outcomeMeasures: z.number().int().optional().describe('Posted outcome measures.'),
188
+ seriousAdverseEvents: z
189
+ .number()
190
+ .int()
191
+ .optional()
192
+ .describe('Distinct serious adverse-event terms.'),
193
+ otherAdverseEvents: z
194
+ .number()
195
+ .int()
196
+ .optional()
197
+ .describe('Distinct other (non-serious) adverse-event terms.'),
198
+ participantFlowPeriods: z.number().int().optional().describe('Participant-flow periods.'),
199
+ baselineMeasures: z.number().int().optional().describe('Baseline characteristic measures.'),
200
+ })
201
+ .optional()
202
+ .describe('Compact counts of posted results, present when hasResults is true. The full resultsSection is intentionally omitted from this record-level tool — fetch it via clinicaltrials_get_study_results or the clinicaltrials://{nctId} resource.'),
159
203
  }),
160
204
  async handler(input, ctx) {
161
205
  const service = getClinicalTrialsService();
162
206
  const raw = await service.getStudy(input.nctId, ctx);
163
207
  const { study, meta } = applyFilters(raw, input);
208
+ // Drop the heavy resultsSection (can exceed ~450KB) from this record-level
209
+ // tool — carry only compact counts so structuredContent and format() stay
210
+ // in parity. Full results live in clinicaltrials_get_study_results and the
211
+ // clinicaltrials://{nctId} resource.
212
+ const resultsSummary = summarizeResults(study);
213
+ const studyOut = { ...study };
214
+ delete studyOut.resultsSection;
164
215
  ctx.log.info('Study fetched', {
165
216
  nctId: input.nctId,
166
217
  locationLimit: input.locationLimit,
@@ -168,7 +219,8 @@ export const getStudy = tool('clinicaltrials_get_study_record', {
168
219
  nearLocation: input.nearLocation != null,
169
220
  });
170
221
  return {
171
- study: study,
222
+ study: studyOut,
223
+ ...(resultsSummary ? { resultsSummary } : {}),
172
224
  filtersApplied: {
173
225
  ...meta,
174
226
  ...(input.locationLimit != null ? { locationLimit: input.locationLimit } : {}),
@@ -370,19 +422,21 @@ export const getStudy = tool('clinicaltrials_get_study_record', {
370
422
  renderOutcomeList('Secondary Outcomes', outcomes.secondaryOutcomes, meta.totalSecondaryOutcomes);
371
423
  if (outcomes.otherOutcomes?.length)
372
424
  renderOutcomeList('Other Outcomes', outcomes.otherOutcomes, meta.totalOtherOutcomes);
373
- // Results summary stub — counts only; full data via clinicaltrials_get_study_results
374
- if (s.hasResults && s.resultsSection) {
375
- const rs = s.resultsSection;
376
- const om = rs.outcomeMeasuresModule;
377
- const ae = rs.adverseEventsModule;
378
- const pf = rs.participantFlowModule;
379
- const bl = rs.baselineCharacteristicsModule;
380
- const aeCount = ae ? (ae.seriousEvents?.length ?? 0) + (ae.otherEvents?.length ?? 0) : 0;
425
+ // Results summary — compact counts mirrored from the resultsSummary output
426
+ // field (the heavy resultsSection is omitted from this tool). Renders every
427
+ // resultsSummary field so content[] and structuredContent stay in parity.
428
+ const rsum = result.resultsSummary;
429
+ if (rsum) {
381
430
  const parts = [
382
- om?.outcomeMeasures?.length ? `${om.outcomeMeasures.length} outcome measures` : '',
383
- aeCount ? `${aeCount} adverse events` : '',
384
- pf?.periods?.length ? `${pf.periods.length} participant flow periods` : '',
385
- bl?.measures?.length ? `${bl.measures.length} baseline measures` : '',
431
+ rsum.outcomeMeasures != null ? `${rsum.outcomeMeasures} outcome measures` : '',
432
+ rsum.seriousAdverseEvents != null
433
+ ? `${rsum.seriousAdverseEvents} serious adverse events`
434
+ : '',
435
+ rsum.otherAdverseEvents != null ? `${rsum.otherAdverseEvents} other adverse events` : '',
436
+ rsum.participantFlowPeriods != null
437
+ ? `${rsum.participantFlowPeriods} participant flow periods`
438
+ : '',
439
+ rsum.baselineMeasures != null ? `${rsum.baselineMeasures} baseline measures` : '',
386
440
  ].filter(Boolean);
387
441
  if (parts.length) {
388
442
  lines.push('');
package/dist/mcp-server/tools/definitions/get-study.tool.js.map CHANGED
@@ -1 +1 @@
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package/dist/mcp-server/tools/definitions/search-studies.tool.d.ts CHANGED
@@ -38,6 +38,11 @@ export declare const searchStudies: import("@cyanheads/mcp-ts-core").ToolDefinit
38
38
  readonly code: JsonRpcErrorCode.ValidationError;
39
39
  readonly when: "A field name in the fields parameter or AREA[] expression is invalid (often a module name instead of a piece name).";
40
40
  readonly recovery: "Call clinicaltrials_get_field_definitions to browse the field tree; use PascalCase piece names like OverallStatus, Phase, or StudyType.";
41
+ }, {
42
+ readonly reason: "enum_invalid";
43
+ readonly code: JsonRpcErrorCode.ValidationError;
44
+ readonly when: "statusFilter or phaseFilter contains a value ClinicalTrials.gov does not accept.";
45
+ readonly recovery: "Call clinicaltrials_get_field_values with fields=[\"OverallStatus\"] or fields=[\"Phase\"] to see the valid enum values the filter accepts.";
41
46
  }, {
42
47
  readonly reason: "query_parse_error";
43
48
  readonly code: JsonRpcErrorCode.ValidationError;
package/dist/mcp-server/tools/definitions/search-studies.tool.d.ts.map CHANGED
@@ -1 +1 @@
1
- {"version":3,"file":"search-studies.tool.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/definitions/search-studies.tool.ts"],"names":[],"mappings":"AAAA;;;GAGG;AAEH,OAAO,EAAQ,CAAC,EAAE,MAAM,wBAAwB,CAAC;AACjD,OAAO,EAAE,gBAAgB,EAAE,MAAM,+BAA+B,CAAC;AAsBjE,eAAO,MAAM,aAAa;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;EAoUxB,CAAC"}
1
+ {"version":3,"file":"search-studies.tool.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/definitions/search-studies.tool.ts"],"names":[],"mappings":"AAAA;;;GAGG;AAEH,OAAO,EAAQ,CAAC,EAAE,MAAM,wBAAwB,CAAC;AACjD,OAAO,EAAE,gBAAgB,EAAE,MAAM,+BAA+B,CAAC;AAsBjE,eAAO,MAAM,aAAa;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;EAkVxB,CAAC"}
package/dist/mcp-server/tools/definitions/search-studies.tool.js CHANGED
@@ -41,6 +41,12 @@ export const searchStudies = tool('clinicaltrials_search_studies', {
41
41
  when: 'A field name in the fields parameter or AREA[] expression is invalid (often a module name instead of a piece name).',
42
42
  recovery: RECOVERY_HINTS.field_invalid,
43
43
  },
44
+ {
45
+ reason: 'enum_invalid',
46
+ code: JsonRpcErrorCode.ValidationError,
47
+ when: 'statusFilter or phaseFilter contains a value ClinicalTrials.gov does not accept.',
48
+ recovery: RECOVERY_HINTS.enum_invalid,
49
+ },
44
50
  {
45
51
  reason: 'query_parse_error',
46
52
  code: JsonRpcErrorCode.ValidationError,
@@ -157,7 +163,7 @@ export const searchStudies = tool('clinicaltrials_search_studies', {
157
163
  searchCriteria: z
158
164
  .record(z.string(), z.unknown())
159
165
  .optional()
160
- .describe('Echo of active query/filter criteria. Present when results are empty.'),
166
+ .describe('Echo of active query/filter criteria applied to this search, including sentinelFilterActive when the default unknown-enrollment exclusion is in effect. Present on every response.'),
161
167
  notice: z
162
168
  .string()
163
169
  .optional()
@@ -198,33 +204,42 @@ export const searchStudies = tool('clinicaltrials_search_studies', {
198
204
  count: result.studies.length,
199
205
  totalCount: result.totalCount,
200
206
  });
201
- // Echo search criteria and recovery guidance on empty results
207
+ // Echo the applied search criteria on every response (not only empty ones)
208
+ // so agents can confirm which filters were actually in effect when a result
209
+ // set is smaller than expected. sentinelFilterActive flags the default
210
+ // unknown-enrollment exclusion, which silently drops EnrollmentCount=99999999
211
+ // studies from RANGE/EnrollmentCount:desc queries.
212
+ const criteria = {};
213
+ if (input.query)
214
+ criteria.query = input.query;
215
+ if (input.conditionQuery)
216
+ criteria.conditionQuery = input.conditionQuery;
217
+ if (input.interventionQuery)
218
+ criteria.interventionQuery = input.interventionQuery;
219
+ if (input.locationQuery)
220
+ criteria.locationQuery = input.locationQuery;
221
+ if (input.sponsorQuery)
222
+ criteria.sponsorQuery = input.sponsorQuery;
223
+ if (input.titleQuery)
224
+ criteria.titleQuery = input.titleQuery;
225
+ if (input.outcomeQuery)
226
+ criteria.outcomeQuery = input.outcomeQuery;
227
+ if (input.statusFilter)
228
+ criteria.statusFilter = input.statusFilter;
229
+ if (input.phaseFilter)
230
+ criteria.phaseFilter = input.phaseFilter;
231
+ if (input.advancedFilter)
232
+ criteria.advancedFilter = input.advancedFilter;
233
+ if (input.geoFilter)
234
+ criteria.geoFilter = input.geoFilter;
235
+ if (input.nctIds)
236
+ criteria.nctIds = input.nctIds;
237
+ if (!input.includeUnknownEnrollment)
238
+ criteria.sentinelFilterActive = true;
239
+ if (Object.keys(criteria).length > 0)
240
+ ctx.enrich({ searchCriteria: criteria });
241
+ // Recovery guidance only when nothing matched.
202
242
  if (result.studies.length === 0) {
203
- const criteria = {};
204
- if (input.query)
205
- criteria.query = input.query;
206
- if (input.conditionQuery)
207
- criteria.conditionQuery = input.conditionQuery;
208
- if (input.interventionQuery)
209
- criteria.interventionQuery = input.interventionQuery;
210
- if (input.locationQuery)
211
- criteria.locationQuery = input.locationQuery;
212
- if (input.sponsorQuery)
213
- criteria.sponsorQuery = input.sponsorQuery;
214
- if (input.titleQuery)
215
- criteria.titleQuery = input.titleQuery;
216
- if (input.outcomeQuery)
217
- criteria.outcomeQuery = input.outcomeQuery;
218
- if (input.statusFilter)
219
- criteria.statusFilter = input.statusFilter;
220
- if (input.phaseFilter)
221
- criteria.phaseFilter = input.phaseFilter;
222
- if (input.advancedFilter)
223
- criteria.advancedFilter = input.advancedFilter;
224
- if (input.geoFilter)
225
- criteria.geoFilter = input.geoFilter;
226
- if (input.nctIds)
227
- criteria.nctIds = input.nctIds;
228
243
  const hasQuery = input.query ||
229
244
  input.conditionQuery ||
230
245
  input.interventionQuery ||
@@ -247,8 +262,6 @@ export const searchStudies = tool('clinicaltrials_search_studies', {
247
262
  noticeParts.push('Remove statusFilter to include studies in all statuses (completed, terminated, etc.).');
248
263
  if (input.phaseFilter)
249
264
  noticeParts.push('Remove phaseFilter to include all trial phases.');
250
- if (Object.keys(criteria).length > 0)
251
- ctx.enrich({ searchCriteria: criteria });
252
265
  if (noticeParts.length > 0)
253
266
  ctx.enrich.notice(noticeParts.join(' '));
254
267
  }
package/dist/mcp-server/tools/definitions/search-studies.tool.js.map CHANGED
@@ -1 +1 @@
1
- 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1
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package/dist/mcp-server/tools/utils/recovery-hints.d.ts CHANGED
@@ -10,6 +10,7 @@ export declare const RECOVERY_HINTS: {
10
10
  readonly study_not_found: "Verify the NCT ID at clinicaltrials.gov or call clinicaltrials_search_studies to discover a valid identifier.";
11
11
  readonly ids_not_found: "Verify each NCT ID exists at clinicaltrials.gov, or call clinicaltrials_search_studies first to discover valid identifiers.";
12
12
  readonly field_invalid: "Call clinicaltrials_get_field_definitions to browse the field tree; use PascalCase piece names like OverallStatus, Phase, or StudyType.";
13
+ readonly enum_invalid: "Call clinicaltrials_get_field_values with fields=[\"OverallStatus\"] or fields=[\"Phase\"] to see the valid enum values the filter accepts.";
13
14
  readonly query_parse_error: "Field-scoped search uses advancedFilter with AREA[FieldName]value (call clinicaltrials_get_field_definitions to look up the right FieldName); free-text fields (query, conditionQuery, etc.) take plain words plus AND, OR, NOT — brackets, parentheses, and commas are reserved by the upstream parser.";
14
15
  readonly path_not_found: "Call clinicaltrials_get_field_definitions with `query` (e.g., \"phase\", \"enrollment\") to find the field path by concept, or omit both arguments for a top-level overview.";
15
16
  readonly rate_limited: "ClinicalTrials.gov rate-limited the request after several retries; wait about a minute before trying again.";
package/dist/mcp-server/tools/utils/recovery-hints.d.ts.map CHANGED
@@ -1 +1 @@
1
- {"version":3,"file":"recovery-hints.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/utils/recovery-hints.ts"],"names":[],"mappings":"AAAA;;;;;;;GAOG;AAEH,eAAO,MAAM,cAAc;;;;;;;CAajB,CAAC"}
1
+ {"version":3,"file":"recovery-hints.d.ts","sourceRoot":"","sources":["../../../../src/mcp-server/tools/utils/recovery-hints.ts"],"names":[],"mappings":"AAAA;;;;;;;GAOG;AAEH,eAAO,MAAM,cAAc;;;;;;;;CAejB,CAAC"}
package/dist/mcp-server/tools/utils/recovery-hints.js CHANGED
@@ -10,6 +10,7 @@ export const RECOVERY_HINTS = {
10
10
  study_not_found: 'Verify the NCT ID at clinicaltrials.gov or call clinicaltrials_search_studies to discover a valid identifier.',
11
11
  ids_not_found: 'Verify each NCT ID exists at clinicaltrials.gov, or call clinicaltrials_search_studies first to discover valid identifiers.',
12
12
  field_invalid: 'Call clinicaltrials_get_field_definitions to browse the field tree; use PascalCase piece names like OverallStatus, Phase, or StudyType.',
13
+ enum_invalid: 'Call clinicaltrials_get_field_values with fields=["OverallStatus"] or fields=["Phase"] to see the valid enum values the filter accepts.',
13
14
  query_parse_error: 'Field-scoped search uses advancedFilter with AREA[FieldName]value (call clinicaltrials_get_field_definitions to look up the right FieldName); free-text fields (query, conditionQuery, etc.) take plain words plus AND, OR, NOT — brackets, parentheses, and commas are reserved by the upstream parser.',
14
15
  path_not_found: 'Call clinicaltrials_get_field_definitions with `query` (e.g., "phase", "enrollment") to find the field path by concept, or omit both arguments for a top-level overview.',
15
16
  rate_limited: 'ClinicalTrials.gov rate-limited the request after several retries; wait about a minute before trying again.',
package/dist/mcp-server/tools/utils/recovery-hints.js.map CHANGED
@@ -1 +1 @@
1
- {"version":3,"file":"recovery-hints.js","sourceRoot":"","sources":["../../../../src/mcp-server/tools/utils/recovery-hints.ts"],"names":[],"mappings":"AAAA;;;;;;;GAOG;AAEH,MAAM,CAAC,MAAM,cAAc,GAAG;IAC5B,eAAe,EACb,+GAA+G;IACjH,aAAa,EACX,6HAA6H;IAC/H,aAAa,EACX,yIAAyI;IAC3I,iBAAiB,EACf,0SAA0S;IAC5S,cAAc,EACZ,0KAA0K;IAC5K,YAAY,EACV,6GAA6G;CACvG,CAAC"}
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+ {"version":3,"file":"recovery-hints.js","sourceRoot":"","sources":["../../../../src/mcp-server/tools/utils/recovery-hints.ts"],"names":[],"mappings":"AAAA;;;;;;;GAOG;AAEH,MAAM,CAAC,MAAM,cAAc,GAAG;IAC5B,eAAe,EACb,+GAA+G;IACjH,aAAa,EACX,6HAA6H;IAC/H,aAAa,EACX,yIAAyI;IAC3I,YAAY,EACV,yIAAyI;IAC3I,iBAAiB,EACf,0SAA0S;IAC5S,cAAc,EACZ,0KAA0K;IAC5K,YAAY,EACV,6GAA6G;CACvG,CAAC"}
package/package.json CHANGED
@@ -1,6 +1,6 @@
1
1
  {
2
2
  "name": "clinicaltrialsgov-mcp-server",
3
- "version": "2.5.5",
3
+ "version": "2.6.0",
4
4
  "mcpName": "io.github.cyanheads/clinicaltrialsgov-mcp-server",
5
5
  "description": "Search ClinicalTrials.gov trials, retrieve study details and results, and match patients to eligible trials via MCP. STDIO or Streamable HTTP.",
6
6
  "main": "dist/index.js",