chromosomix 0.18.0 → 0.20.0

package/dist/assets/{annotations.worker-Bd03nKdJ.js → annotations.worker-DPRPwDSy.js}

@@ -1,28 +1,28 @@
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Float32Array(0)};const A=4,s=A+n*4,r=s+n*4;return{starts:new Int32Array(t.buffer,t.byteOffset+A,n),ends:new Int32Array(t.buffer,t.byteOffset+s,n),scores:new Float32Array(t.buffer,t.byteOffset+r,n)}}function Dc(t){const n=new DataView(t.buffer,t.byteOffset,t.byteLength).getUint32(0,!0);if(n===0)return{starts:new Int32Array(0),ends:new Int32Array(0),scores:new Float32Array(0),minScores:new Float32Array(0),maxScores:new Float32Array(0)};const A=4,s=A+n*4,r=s+n*4,o=r+n*4,i=o+n*4;return{starts:new Int32Array(t.buffer,t.byteOffset+A,n),ends:new Int32Array(t.buffer,t.byteOffset+s,n),scores:new Float32Array(t.buffer,t.byteOffset+r,n),minScores:new Float32Array(t.buffer,t.byteOffset+o,n),maxScores:new Float32Array(t.buffer,t.byteOffset+i,n)}}async function Mc(t,e,n,A,s,r){await ts();const o=Fo(t,e,n,A,s,r);return bc(o)}async function Fc(t,e,n,A,s,r,o){await ts();const i=So(t,e,n,A,s,r,o);return Dc(i)}function es(t){const e=new Uint32Array(t.length),n=new Uint32Array(t.length);for(let A=0;A<t.length;A++){const s=t[A];e[A]=s.offset,n[A]=s.length}return{inputOffsets:e,inputLengths:n}}async function Sc(t,e,n){const{inputOffsets:A,inputLengths:s}=es(e);return kc(t,A,s,n)}async function Rc(t,e,n,A,s){const{inputOffsets:r,inputLengths:o}=es(e);return Mc(t,r,o,n,A,s)}async function Lc(t,e,n,A,s,r){const{inputOffsets:o,inputLengths:i}=es(e);return Fc(t,o,i,n,A,s,r)}const ns=new TextDecoder("utf8");function rt(t,e=0){return new DataView(t.buffer,t.byteOffset+e,t.length-e)}function j(t,e){return t.getUint32(e,!0)+t.getUint32(e+4,!0)*2**32}function dA(t,e,n){const A=t.indexOf(0,e),s=A!==-1&&A<e+n?A:e+n;return ns.decode(t.subarray(e,s))}function xc(t){const e=t.toSorted((s,r)=>s.offset-r.offset),n=[];let A;for(const s of e)A&&s.offset-(A.offset+A.length)<=2e3?(A.length=Math.max(A.length,s.offset+s.length-A.offset),A.blocks.push(s)):(A={blocks:[s],length:s.length,offset:s.offset},n.push(A));return n}const Os=610839776;function Gc(t,e){let n=0;for(const s of t)n+=s.length;let A=0;return e?.(0,n),s=>{A+=s,e?.(A,n)}}function Ie(t,e,n,A){return t<A&&e>n}function Lo(t,e){return e?t/e:t}function Uc(t,e){const n=[];let A=0;const s=rt(t);for(;A<t.byteLength;){const r=s.getUint32(A,!0);A+=4;const o=s.getUint32(A,!0);A+=4;const i=s.getUint32(A,!0);A+=4;const a=s.getUint32(A,!0);A+=4;const c=s.getFloat32(A,!0);A+=4;const l=s.getFloat32(A,!0);A+=4;const g=s.getFloat32(A,!0);A+=8,(!e||r===e.chrId&&Ie(o,i,e.start,e.end))&&n.push({start:o,end:i,maxScore:l,minScore:c,summary:!0,score:Lo(g,a)})}return n}function vc(t,e,n){const A=[];let s=0;const r=rt(t);for(;s<t.byteLength;){const o=s,i=r.getUint32(s,!0);s+=4;const a=r.getInt32(s,!0);s+=4;const c=r.getInt32(s,!0);s+=4;const l=t.indexOf(0,s),g=l===-1?t.length:l,f=ns.decode(t.subarray(s,g));s=g+1,(!n||i===n.chrId&&Ie(a,c,n.start,n.end))&&A.push({start:a,end:c,rest:f,uniqueId:`bb-${e}-${o}`})}return A}function Tc(t,e){const n=rt(t),A=n.getInt32(4,!0),s=n.getUint32(12,!0),r=n.getUint32(16,!0),o=n.getUint8(20),i=n.getUint16(22,!0);let a=24;const c=[];switch(o){case 1:{for(let l=0;l<i;l++){const g=n.getInt32(a,!0);a+=4;const f=n.getInt32(a,!0);a+=4;const h=n.getFloat32(a,!0);a+=4,(!e||Ie(g,f,e.start,e.end))&&c.push({start:g,end:f,score:h})}break}case 2:{for(let l=0;l<i;l++){const g=n.getInt32(a,!0);a+=4;const f=n.getFloat32(a,!0);a+=4;const h=g+r;(!e||Ie(g,h,e.start,e.end))&&c.push({score:f,start:g,end:h})}break}case 3:{for(let l=0;l<i;l++){const g=n.getFloat32(a,!0);a+=4;const f=A+l*s,h=f+r;(!e||Ie(f,h,e.start,e.end))&&c.push({score:g,start:f,end:h})}break}}return c}function _s(t,e){const n=rt(t),A=n.getInt32(4,!0),s=n.getUint32(12,!0),r=n.getUint32(16,!0),o=n.getUint8(20),i=n.getUint16(22,!0),a=new Int32Array(i),c=new Int32Array(i),l=new Float32Array(i),g=e.start,f=e.end;let h=0;switch(o){case 1:{let u=24;for(let I=0;I<i;I++){const d=n.getInt32(u,!0),C=n.getInt32(u+4,!0);d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u+8,!0),h++),u+=12}break}case 2:{let u=24;for(let I=0;I<i;I++){const d=n.getInt32(u,!0),C=d+r;d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u+4,!0),h++),u+=8}break}case 3:{let u=24;for(let I=0;I<i;I++){const d=A+I*s,C=d+r;d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u,!0),h++),u+=4}break}}return h<i?{starts:a.subarray(0,h),ends:c.subarray(0,h),scores:l.subarray(0,h)}:{starts:a,ends:c,scores:l}}function Ks(t,e){const n=rt(t),A=Math.floor(t.byteLength/32),s=new Int32Array(A),r=new Int32Array(A),o=new Float32Array(A),i=new Float32Array(A),a=new Float32Array(A);let c=0,l=0;for(;l<t.byteLength;){const g=n.getUint32(l,!0);l+=4;const f=n.getUint32(l,!0);l+=4;const h=n.getUint32(l,!0);l+=4;const u=n.getUint32(l,!0);l+=4;const I=n.getFloat32(l,!0);l+=4;const d=n.getFloat32(l,!0);l+=4;const C=n.getFloat32(l,!0);l+=8,g===e.chrId&&Ie(f,h,e.start,e.end)&&(s[c]=f,r[c]=h,o[c]=Lo(C,u),i[c]=I,a[c]=d,c++)}return c<A?{starts:s.subarray(0,c),ends:r.subarray(0,c),scores:o.subarray(0,c),minScores:i.subarray(0,c),maxScores:a.subarray(0,c)}:{starts:s,ends:r,scores:o,minScores:i,maxScores:a}}function ve(t,e,n,A){if(t.length===1)return e(t[0]);const s=new A(n);let r=0;for(const o of t){const i=e(o);s.set(i,r),r+=i.length}return s}function xo(t){let e=0;for(const n of t)e+=n.starts.length;return e}function Go(t){const e=xo(t);return{starts:ve(t,n=>n.starts,e,Int32Array),ends:ve(t,n=>n.ends,e,Int32Array),scores:ve(t,n=>n.scores,e,Float32Array),isSummary:!1}}function Jc(t){const e=xo(t),{starts:n,ends:A,scores:s}=Go(t);return{starts:n,ends:A,scores:s,minScores:ve(t,r=>r.minScores,e,Float32Array),maxScores:ve(t,r=>r.maxScores,e,Float32Array),isSummary:!0}}function Uo(t){let e=0;for(const i of t)for(const a of i)e+=a.starts.length;const n=new Int32Array(e),A=new Int32Array(e),s=new Float32Array(e),r=[0];let o=0;for(const i of t){for(const a of i)n.set(a.starts,o),A.set(a.ends,o),s.set(a.scores,o),o+=a.starts.length;r.push(o)}return{starts:n,ends:A,scores:s,regionOffsets:r,totalCount:e}}function $c(t){const{starts:e,ends:n,scores:A,regionOffsets:s}=Uo(t);return{starts:e,ends:n,scores:A,regionOffsets:s,isSummary:!1}}function Yc(t){const{starts:e,ends:n,scores:A,regionOffsets:s,totalCount:r}=Uo(t),o=new Float32Array(r),i=new Float32Array(r);let a=0;for(const c of t)for(const l of c)o.set(l.minScores,a),i.set(l.maxScores,a),a+=l.starts.length;return{starts:e,ends:n,scores:A,minScores:o,maxScores:i,regionOffsets:s,isSummary:!0}}function qs(t,e,n,A){switch(t){case"summary":return Uc(e,A);case"bigwig":return Tc(e,A);case"bigbed":return vc(e,n,A)}}class Oc{rTreePromise;rTreeNodeCache=new Bn({cache:new fc({maxSize:1e3}),fill:async({length:e,offset:n},A)=>this.bbi.read(e,n,{signal:A})});bbi;refsByName;rTreeOffset;uncompressBufSize;blockType;constructor(e,n,A,s,r){if(!(A>=0))throw new Error("invalid rTreeOffset!");this.bbi=e,this.refsByName=n,this.rTreeOffset=A,this.uncompressBufSize=s,this.blockType=r}async _collectBlocks(e,n,A,s){const r=this.refsByName[e];if(r===void 0||n>=A)return;this.rTreePromise||(this.rTreePromise=this.bbi.read(48,this.rTreeOffset,{signal:s?.signal}).catch(u=>{throw this.rTreePromise=void 0,u}));const o=await this.rTreePromise,i=rt(o),a=i.getUint32(0,!0);if(a!==Os)throw new Error(`invalid cirTree magic: 0x${a.toString(16)} (expected 0x${Os.toString(16)}) at offset ${this.rTreeOffset}, file may be corrupt or unsupported`);const l=4+i.getUint32(4,!0)*32,g=(u,I,d,C)=>(u<r||u===r&&I<A)&&(d>r||d===r&&C>n),f=[];let h=[this.rTreeOffset+48];for(;h.length>0;){const u=hc(h.map(d=>({min:d,max:d+l}))),I=[];for(const{min:d,max:C}of u){const E=C-d,B=d,Q=await this.rTreeNodeCache.get(`${E}_${B}`,{length:E,offset:B},s?.signal);for(const m of h)if(d<=m&&m<=C){const p=Q.subarray(m-B),w=rt(p),y=w.getUint8(0),N=w.getUint16(2,!0);if(y===1||y===0){const k=y===1?32:24;let b=4;for(let D=0;D<N;D++){const F=w.getUint32(b,!0),R=w.getUint32(b+4,!0),v=w.getUint32(b+8,!0),x=w.getUint32(b+12,!0);if(g(F,R,v,x)){const Y=j(w,b+16);if(y===1){const J=j(w,b+24);f.push({offset:Y,length:J})}else I.push(Y)}b+=k}}}}h=I}return{blocks:f,chrId:r}}async readWigData(e,n,A,s){const r=await this._collectBlocks(e,n,A,s);if(!r)return[];const{blocks:o,chrId:i}=r;return this.readFeatures(o,{...s,request:{chrId:i,start:n,end:A}})}async getBlockSizeForRange(e,n,A,s){const r=await this._collectBlocks(e,n,A,s);let o=0;if(r)for(const i of r.blocks)o+=i.length;return o}async getBlockSizeForRangeMulti(e,n={}){const{blockByOffset:A}=await this._collectBlocksMulti(e,n);let s=0;for(const r of A.values())s+=r.length;return s}async _collectBlocksMulti(e,n){const A=await Promise.all(e.map(({refName:o,start:i,end:a})=>this._collectBlocks(o,i,a,n))),s=new Map,r=new Map;for(let o=0;o<A.length;o++){const i=A[o];if(i){const{start:a,end:c}=e[o],l={chrId:i.chrId,start:a,end:c};for(const g of i.blocks){const f=r.get(g.offset);f?f.push({regionIndex:o,request:l}):(s.set(g.offset,g),r.set(g.offset,[{regionIndex:o,request:l}]))}}}return{blockByOffset:s,tagsByOffset:r}}async readWigDataMulti(e,n={}){const A=e.map(()=>[]),{blockByOffset:s,tagsByOffset:r}=await this._collectBlocksMulti(e,n),{blockType:o}=this;return await this._forEachDecodedBlock([...s.values()],n.signal,n.onProgress,(i,a)=>{const c=r.get(a);if(c)for(const{regionIndex:l,request:g}of c){const f=qs(o,i,a,g);for(const h of f)A[l].push(h)}}),A}assertNotBigBed(e){if(this.blockType==="bigbed")throw new Error(`${e} is not supported for BigBed data; use getFeatures/getFeaturesMulti instead`)}async readWigDataAsArrays(e,n,A,s){this.assertNotBigBed("getFeaturesAsArrays");const r=await this._collectBlocks(e,n,A,s),o=r?r.blocks:[],i={chrId:r?r.chrId:0,start:n,end:A};return this.blockType==="summary"?this._readSummaryFeaturesAsArrays(o,i,s):this._readBigWigFeaturesAsArrays(o,i,s)}async readWigDataAsArraysMulti(e,n={}){this.assertNotBigBed("getFeaturesAsArraysMulti");const A=await this._collectBlocksMulti(e,n);return this.blockType==="summary"?Yc(await this._readBlocksAsArraysMulti(A,e.length,(s,r)=>Ks(s,r),n)):$c(await this._readBlocksAsArraysMulti(A,e.length,(s,r)=>_s(s,r),n))}async _readBlocksAsArraysMulti(e,n,A,s){const{blockByOffset:r,tagsByOffset:o}=e,i=Array.from({length:n},()=>[]);return await this._forEachDecodedBlock([...r.values()],s.signal,s.onProgress,(a,c)=>{const l=o.get(c);if(l)for(const{regionIndex:g,request:f}of l){const h=A(a,f);h.starts.length>0&&i[g].push(h)}}),i}async _forEachBlockGroup(e,n,A,s){const r=xc(e),o=Gc(r,A);for(const i of r){const a=await this.bbi.read(i.length,i.offset,{signal:n});o(i.length),await s(a,i.blocks.map(c=>({offset:c.offset-i.offset,length:c.length})),i.offset)}}async _forEachDecodedBlock(e,n,A,s){const{uncompressBufSize:r}=this;await this._forEachBlockGroup(e,n,A,async(o,i,a)=>{if(r>0){const{data:c,offsets:l}=await Sc(o,i,r);for(let g=0;g<i.length;g++)s(c.subarray(l[g],l[g+1]),a+i[g].offset)}else for(const c of i)s(o.subarray(c.offset,c.offset+c.length),a+c.offset)})}async readFeatures(e,n={}){const{blockType:A}=this,{signal:s,request:r,onProgress:o}=n,i=[];return await this._forEachDecodedBlock(e,s,o,(a,c)=>{const l=qs(A,a,c,r);for(const g of l)i.push(g)}),i}async _readBlocksAsArrays(e,n,A,s,r){const{uncompressBufSize:o}=this,i=[],a=c=>{c.starts.length>0&&i.push(c)};return await this._forEachBlockGroup(e,n,r,async(c,l)=>{if(o>0)a(await A(c,l));else for(const g of l)a(s(c.subarray(g.offset,g.offset+g.length)))}),i}async _readBigWigFeaturesAsArrays(e,n,A={}){const s=await this._readBlocksAsArrays(e,A.signal,(r,o)=>Rc(r,o,this.uncompressBufSize,n.start,n.end),r=>_s(r,n),A.onProgress);return Go(s)}async _readSummaryFeaturesAsArrays(e,n,A={}){const s=await this._readBlocksAsArrays(e,A.signal,(r,o)=>Lc(r,o,this.uncompressBufSize,n.chrId,n.start,n.end),r=>Ks(r,n),A.onProgress);return Jc(s)}}const _c=-2003829722,Hs=-2021002517;class vo{bbi;headerP;getHeader(e){return this.headerP||(this.headerP=this._getHeader(e).catch(n=>{throw this.headerP=void 0,n})),this.headerP}constructor(e){const{filehandle:n,path:A,url:s}=e;if(n)this.bbi=n;else if(s)this.bbi=new Do(s);else if(A)this.bbi=new ac(A);else throw new Error("no file given")}async _getHeader(e){const n=await this._getMainHeader(e),A=await this._readChromosomeTree(n,e);return{...n,...A}}async _getMainHeader(e,n=2e3){const A=await this.bbi.read(n,0,e),s=rt(A);let r=0;const o=s.getInt32(r,!0);if(r+=4,o!==_c&&o!==Hs)throw new Error("not a BigWig/BigBed file");const i=s.getUint16(r,!0);r+=2;const a=s.getUint16(r,!0);r+=2;const c=j(s,r);r+=8;const l=j(s,r);r+=8;const g=j(s,r);r+=8;const f=s.getUint16(r,!0);r+=2;const h=s.getUint16(r,!0);r+=2;const u=j(s,r);r+=8;const I=j(s,r);r+=8;const d=s.getUint32(r,!0);r+=4;const C=j(s,r);r+=8;const E=[];for(let y=0;y<a;y++){const N=s.getUint32(r,!0);r+=4,r+=4;const k=j(s,r);r+=8;const b=j(s,r);r+=8,E.push({reductionLevel:N,dataOffset:k,indexOffset:b})}const B=o===Hs?"bigbed":"bigwig",Q=A.length<n,m=u!==0&&!A.includes(0,u);if(!Q&&(u>n||I>n-40||m))return this._getMainHeader(e,n*2);let p;if(I){const y=rt(A,I);p={basesCovered:j(y,0),scoreMin:y.getFloat64(8,!0),scoreMax:y.getFloat64(16,!0),scoreSum:y.getFloat64(24,!0),scoreSumSquares:y.getFloat64(32,!0)}}else throw new Error("no stats");let w="";if(u){const y=A.indexOf(0,u),N=y===-1?A.length:y;w=ns.decode(A.subarray(u,N))}return{zoomLevels:E,magic:o,extHeaderOffset:C,numZoomLevels:a,fieldCount:f,totalSummary:p,definedFieldCount:h,uncompressBufSize:d,asOffset:u,chromosomeTreeOffset:c,totalSummaryOffset:I,unzoomedDataOffset:l,unzoomedIndexOffset:g,fileType:B,version:i,autoSql:w}}async _readChromosomeTree(e,n){const A=[],s={},r=e.chromosomeTreeOffset,o=rt(await this.bbi.read(32,r,n)),i=o.getUint32(4,!0),a=o.getUint32(8,!0),c=o.getUint32(12,!0),l=4+i*(a+Math.max(c,8)),g=async f=>{const h=await this.bbi.read(l,f,n),u=rt(h),I=u.getUint8(0),d=u.getUint16(2,!0);let C=4;if(I)for(let E=0;E<d;E++){const B=dA(h,C,a);C+=a;const Q=u.getUint32(C,!0);C+=4;const m=u.getUint32(C,!0);C+=4,s[B]=Q,A[Q]={name:B,id:Q,length:m}}else{const E=[];for(let B=0;B<d;B++){C+=a;const Q=j(u,C);C+=8,E.push(g(Q))}await Promise.all(E)}};return await g(r+32),{refsByName:s,refsByNumber:A}}viewCache=new Map;getOrCreateBlockView(e,n,A,s){const r=`${n}_${s}`;let o=this.viewCache.get(r);return o||(o=new Oc(this.bbi,e,n,A,s),this.viewCache.set(r,o)),o}async getUnzoomedView(e){const{unzoomedIndexOffset:n,refsByName:A,uncompressBufSize:s,fileType:r}=await this.getHeader(e);return this.getOrCreateBlockView(A,n,s,r)}async _getView(e){const{basesPerSpan:n,scale:A}=e??{},s=n?1/n:A??1;return this.getView(s,e)}async getFeatures(e,n,A,s){return(await this._getView(s)).readWigData(e,n,A,s)}async getRegionByteSize(e,n,A,s){return(await this._getView(s)).getBlockSizeForRange(e,n,A,s)}async getRegionByteSizeMulti(e,n){return(await this._getView(n)).getBlockSizeForRangeMulti(e,n)}async getFeaturesMulti(e,n){return(await this._getView(n)).readWigDataMulti(e,n)}async getFeaturesAsArrays(e,n,A,s){return(await this._getView(s)).readWigDataAsArrays(e,n,A,s)}async getFeaturesAsArraysMulti(e,n){return(await this._getView(n)).readWigDataAsArraysMulti(e,n)}}class To extends vo{async getView(e,n){const{zoomLevels:A,refsByName:s,uncompressBufSize:r}=await this.getHeader(n),o=1/e,i=A.length-1;for(let a=i;a>=0;a-=1){const c=A[a];if(c.reductionLevel<=2*o)return this.getOrCreateBlockView(s,c.indexOffset,r,"summary")}return this.getUnzoomedView(n)}}function Kc(t,e){if(e<0)return;let n=0;for(let s=0;s<e;s++){if(n=t.indexOf("	",n),n===-1)return;n++}const A=t.indexOf("	",n);return A===-1?t.slice(n):t.slice(n,A)}function Ws(t,e){return t<e?-1:t>e?1:0}async function Jo(t,e,n,A,s,r,o,i){const a=4+n*(A+s),c=await t.read(a,e,i),l=rt(c),g=l.getInt8(0),f=l.getInt16(2,!0);let h=4;if(g===0){const u=[];for(let B=0;B<f;B++){const Q=dA(c,h,A);h+=A;const m=j(l,h);h+=8,u.push({key:Q,offset:m})}let I=0,d=u.length-1,C=-1;for(;I<=d;){const B=Math.floor((I+d)/2);Ws(r,u[B].key)>=0?(C=B,I=B+1):d=B-1}const E=u[Math.max(C,0)].offset;return Jo(t,E,n,A,s,r,o,i)}else if(g===1){const u=[];for(let Q=0;Q<f;Q++){const m=dA(c,h,A);h+=A;const p=j(l,h);h+=8;const w=l.getUint32(h,!0);h+=4,h+=4,u.push({key:m,offset:p,length:w})}let I=0,d=u.length-1,C=-1;for(;I<=d;){const Q=Math.floor((I+d)/2),m=Ws(r,u[Q].key);if(m===0){C=Q;break}else m<0?d=Q-1:I=Q+1}if(C===-1)return[];let E=C;for(;E>0&&u[E-1].key===r;)E--;let B=C;for(;B<u.length-1&&u[B+1].key===r;)B++;return u.slice(E,B+1).map(Q=>({...Q,field:o}))}return[]}class $o extends vo{indicesP;readIndices(e={}){return this.indicesP||(this.indicesP=this._readIndices(e).catch(n=>{throw this.indicesP=void 0,n})),this.indicesP}async getView(e,n){return this.getUnzoomedView(n)}async _readIndices(e){const{extHeaderOffset:n}=await this.getHeader(e);if(n===0)return[];const A=await this.bbi.read(64,n,e),s=rt(A),r=s.getUint16(2,!0),o=j(s,4);if(r===0)return[];const i=20,a=i*r,c=await this.bbi.read(a,o,e),l=[];for(let g=0;g<r;g+=1){const f=rt(c,g*i),h=f.getInt16(0,!0),u=f.getInt16(2,!0),I=j(f,4),d=f.getInt16(16,!0);l.push({type:h,fieldcount:u,offset:I,field:d})}return l}async searchExtraIndexBlocks(e,n={}){const A=await this.readIndices(n);if(A.length===0)return[];const s=A.map(async o=>{const{offset:i,field:a}=o,c=await this.bbi.read(32,i,n),l=rt(c),g=l.getInt32(4,!0),f=l.getInt32(8,!0),h=l.getInt32(12,!0);return Jo(this.bbi,i+32,g,f,h,e,a,n)});return(await Promise.all(s)).flat()}async searchExtraIndex(e,n={}){const A=await this.searchExtraIndexBlocks(e,n);if(A.length===0)return[];const s=await this.getUnzoomedView(n),r=new Map;for(const i of A){const a=i.field??0,c=r.get(a);c?c.set(i.offset,i):r.set(a,new Map([[i.offset,i]]))}return(await Promise.all([...r].map(async([i,a])=>(await s.readFeatures([...a.values()],n)).map(l=>({...l,field:i}))))).flat().filter(i=>i.rest?Kc(i.rest,i.field-3)===e:!1)}}const qc=["exact","case","decorated","prefix","padded","roman","organelle","accession","version"],Ps=new Set(["gi","gb","ref","emb","dbj","tpg","tpe","tpd","lcl","pir","prf","sp","tr","pdb","ena","bbs"]);function As(t){let e=t.trim().split(/\s+/)[0]??"";if(e=e.replace(/[,;]+$/,""),e.includes("|")){const n=e.split("|").filter(A=>A!=="");if(n.some(A=>Ps.has(A.toLowerCase()))){const A=n.filter((s,r)=>Ps.has(s.toLowerCase())?!1:!(/^[0-9]+$/.test(s)&&r>0&&n[r-1].toLowerCase()==="gi"));A.length>0&&(e=A[A.length-1])}}return e}const Yo=/^(?:chromosome|chrom|chr)[ _.-]?/i;function Oo(t){const e=t.replace(Yo,"");if(e===""||e===t)return null;const n=e.toLowerCase();return/^[0-9]/.test(e)||mn.has(n)||En.has(n)||Tn(e)>0||/^un[_.-]/i.test(e)||/^[A-Za-z]{1,2}[0-9]/.test(e)||Ko.test(e)||qo.test(e.replace(/\.[0-9]+$/,""))?e:null}const Hc=/^(?:lg|linkage_?group|group)[ _.-]?(?=[0-9])/i,_o=/_(random|alt|fix|hap\d+|maternal|paternal)$/i,Wc=/(?:^|[_.-])([A-Z]{2}[0-9]{5,6})v([0-9]+)(?:$|[_.-])/,Ko=/^(N[CGTWZ]|AC)_([0-9]{5,})$/i,qo=/^[A-Z]{1,6}[0-9]{5,8}$/,Pc=[["mito",["m","mt","mtdna","mito","mitochondrion","mitochondria","mitochondrial","mitochondrion_genome","dmel_mitochondrion_genome","mitochondrial_genome","mitochondrion_dna","chrmt","nc_012920","j01415","nc_001224","nc_005089"]],["plastid",["c","pt","cp","chloroplast","plastid","chloroplast_genome","chrc","nc_000932"]],["2micron",["2-micron","2micron","2u","2-micron_plasmid","nc_001398"]]],En=new Map;for(const[t,e]of Pc)for(const n of e)En.set(n,t);const mn=new Set(["x","y","z","w"]),zc=/^(XL|L|X{0,3})(IX|IV|V?I{0,3})$/i,Xc={"":0,x:10,xx:20,xxx:30,xl:40,l:50},Vc={"":0,i:1,ii:2,iii:3,iv:4,v:5,vi:6,vii:7,viii:8,ix:9};function Tn(t){const e=zc.exec(t);if(e===null)return 0;const n=Xc[e[1].toLowerCase()],A=Vc[e[2].toLowerCase()];return n===void 0||A===void 0?0:n+A}const Zc=[{from:1,to:22,first:1,tail:["x","y"]},{from:67,to:85,first:1,tail:["x","y"]}];function jc(t){for(const e of Zc){if(t>=e.from&&t<=e.to)return String(e.first+(t-e.from));const n=t-e.to-1;if(n>=0&&n<e.tail.length)return e.tail[n]}return null}const CA=200;function tl(t){return t.length<2||mn.has(t.toLowerCase())?!1:Tn(t)>0}function Ho(t){const e=t.map(a=>Wo(a)),A=e.filter(a=>tl(a)).length>=2,s=e.filter(a=>/^[0-9]+$/.test(a)&&Number(a)>=1&&Number(a)<=CA),r=s.length<CA,o=a=>e.some(c=>c.toLowerCase()===a),i=r&&s.length>=2;return{roman:A,ordinals:r,xIsTen:A&&!i&&(o("ix")||o("xi"))}}function Wo(t){const e=As(t);return(Oo(e)??e).replace(_o,"")}function gn(t,e){const n=[],A=As(t);A!==t.trim()&&n.push("decorated");const s=Oo(A),r=s??A;s!==null&&n.push("prefix");const o=_o.exec(r),i=o===null?r:r.slice(0,o.index),a=o===null?"":`+${o[1].toLowerCase()}`,c=i.toLowerCase(),l=Wc.exec(r);if(l!==null)return n.push("accession"),{key:`acc:${l[1].toLowerCase()}`,via:n,version:l[2],opaque:!1};const g=/^(.*?)\.([0-9]+)$/.exec(i),f=g===null?i:g[1],h=g===null?null:g[2],u=En.get(c)??En.get(f.toLowerCase());if(u!==void 0)return u!==c&&n.push("organelle"),{key:`org:${u}`,via:n,version:h,opaque:!1};const I=Ko.exec(f);if(I!==null){n.push("accession");const E=I[1].toLowerCase()==="nc"?jc(Number(I[2])):null;return E!==null?{key:mn.has(E)?`sex:${E}${a}`:`num:${E}${a}`,via:n,version:h,opaque:!1}:{key:`acc:${f.toLowerCase()}${a}`,via:n,version:h,opaque:!1}}if(qo.test(f))return n.push("accession"),{key:`acc:${f.toLowerCase()}${a}`,via:n,version:h,opaque:!1};if(/^[0-9]+$/.test(i)&&e.ordinals&&Number(i)<=CA)return/^0[0-9]/.test(i)&&n.push("padded"),{key:`num:${Number(i)}${a}`,via:n,version:null,opaque:!1};const d=/^([0-9]{1,2})([a-z]{1,2})$/i.exec(i);if(d!==null&&e.ordinals)return d[1].startsWith("0")&&n.push("padded"),{key:`num:${Number(d[1])}${d[2].toLowerCase()}${a}`,via:n,version:null,opaque:!1};const C=Hc.exec(i);if(C!==null){const E=i.slice(C[0].length);if(/^[0-9]+$/.test(E))return/^0[0-9]/.test(E)&&n.push("padded"),{key:`lg:${Number(E)}${a}`,via:n,version:null,opaque:!1}}if(mn.has(c)&&!(c==="x"&&e.xIsTen))return{key:`sex:${c}${a}`,via:n,version:null,opaque:!1};if(e.roman){const E=Tn(i);if(E>0)return n.push("roman"),{key:`num:${E}${a}`,via:n,version:null,opaque:!1}}return{key:`raw:${c}${a}`,via:n,version:null,opaque:!0}}function Ee(t){return qc.indexOf(t)}function el(t,e){let n="case";for(const A of[...t.via,...e.via])Ee(A)>Ee(n)&&(n=A);return n}function tA(t,e){return t===void 0||e===void 0||t<=0||e<=0?"unknown":t===e?"agree":"differ"}const zs=new WeakMap;class St{names;context;styleCache=null;get style(){return this.styleCache??=Al(this.names,this.context),this.styleCache}exact=new Map;folded=new Map;keyed=new Map;constructor(e){this.names=e.map(n=>n.name),this.context=Ho(this.names);for(const n of e){this.exact.has(n.name)||this.exact.set(n.name,n),Xs(this.folded,n.name.toLowerCase(),n);const A=gn(n.name,this.context);Xs(this.keyed,A.key,{sequence:n,canon:A})}}static of(e){return new St(e)}static ofNames(e){return new St(e.map(n=>({name:n})))}static for(e){const n=zs.get(e);if(n!==void 0)return n;const A=typeof e[0]=="string"?St.ofNames(e):St.of(e);return zs.set(e,A),A}has(e){return this.exact.has(e)}find(e,n={}){const{length:A}=n,s=this.exact.get(e);if(s!==void 0)return{name:s.name,asked:e,tier:"exact",lengths:tA(A,s.length)};const r=this.folded.get(e.toLowerCase());if(r!==void 0&&r.length===1)return{name:r[0].name,asked:e,tier:"case",lengths:tA(A,r[0].length)};const o=n.from??this.context,i=this.byKey(e,gn(e,o),A);if(i!==null)return i;if(!o.roman){const a=Wo(e).toLowerCase();if(a!=="x"&&a!=="l"&&Tn(a)>0)return this.byKey(e,gn(e,{...o,roman:!0,xIsTen:!1}),A)}return null}byKey(e,n,A){const s=this.keyed.get(n.key);if(s===void 0||s.length===0)return null;const r=nl(s,A);if(r===null)return null;const o=el(n,r.canon),i=n.version!==null&&r.canon.version!==null&&n.version!==r.canon.version;return{name:r.sequence.name,asked:e,tier:i&&Ee(o)<Ee("version")?"version":o,lengths:tA(A,r.sequence.length)}}}function nl(t,e){if(t.length===1)return t[0];if(e===void 0||e<=0)return null;const n=t.filter(A=>A.sequence.length===e);return n.length===1?n[0]:null}function Xs(t,e,n){const A=t.get(e);A===void 0?t.set(e,[n]):A.push(n)}function Al(t,e=Ho(t)){if(t.length===0)return"empty";let n=0,A=0,s=0,r=0;for(const i of t){const a=gn(i,e);if(a.opaque){r++;continue}a.via.includes("accession")?s++:Yo.test(As(i))?n++:A++}const o=n+A+s;return o===0||r>o*4?"assembly":e.roman&&n<=A?"roman":s>n&&s>A?"accession":n>0&&A>0?"mixed":n>0?e.roman?"roman":"ucsc":e.roman?"roman":"ensembl"}function sl(t,e){const n=St.of(e),A=St.of(t).context,s=[];for(const g of t){const f=n.find(g.name,{length:g.length,from:A});f!==null&&s.push({source:g,match:f})}s.sort((g,f)=>Ee(g.match.tier)-Ee(f.match.tier));const r=new Map,o=new Set;for(const g of s){const f=r.get(g.match.name);f===void 0?r.set(g.match.name,{source:g.source.name,tier:g.match.tier}):f.tier===g.match.tier&&o.add(g.match.name)}const i=new Map,a=[];let c=0;for(const g of s){const f=r.get(g.match.name);f===void 0||f.source!==g.source.name||o.has(g.match.name)||(i.set(g.source.name,g.match),g.match.tier!=="exact"&&c++,g.match.lengths==="differ"&&a.push(g.match))}const l=t.map(g=>g.name).filter(g=>!i.has(g));return{pairs:i,unmatched:l,contested:a,renamed:c}}function pe(t,e){const n=sl(t,e),A=new Map,s=t.map(r=>{const o=n.pairs.get(r.name);return o===void 0?r.name:(A.set(o.name,r.name),o.name)});for(const r of t)A.has(r.name)||A.set(r.name,r.name);return{names:s,sourceOf:A,renamed:n.renamed,contested:n.contested}}function rl(t){return t.map(e=>({name:e}))}function Kt(t,e){const n=ol(t),A=n.get(e);if(A!==void 0)return A;const s=St.for(t).find(e);return s===null?-1:n.get(s.name)??-1}const Vs=new WeakMap;function ol(t){const e=Vs.get(t);if(e!==void 0)return e;const n=new Map;return t.forEach((A,s)=>{const r=typeof A=="string"?A:A.name;n.has(r)||n.set(r,s)}),Vs.set(t,n),n}class Rt extends Error{code;detail;constructor(e,n,A={}){super(n),this.name="ViewerError",this.code=e,this.detail=A}}const eA=new Intl.NumberFormat(void 0,{maximumFractionDigits:0}),il=new Intl.NumberFormat(void 0,{maximumFractionDigits:3}),al=new Intl.NumberFormat(void 0,{maximumSignificantDigits:3}),Zs=new Map,cl=new Intl.NumberFormat("en-US",{maximumFractionDigits:0}),G={int(t){return Number.isFinite(t)?eA.format(t):"—"},num(t){if(!Number.isFinite(t))return"—";if(Number.isInteger(t))return eA.format(t);const e=Math.abs(t);return e>=.001?il.format(t):e>=1e-7?al.format(t):t.toExponential(2)},fixed(t,e){if(!Number.isFinite(t))return"—";let n=Zs.get(e);return n===void 0&&(n=new Intl.NumberFormat(void 0,{minimumFractionDigits:e,maximumFractionDigits:e}),Zs.set(e,n)),n.format(t)},pct(t,e=1){return Number.isFinite(t)?`${(t*100).toFixed(e)}%`:"—"},pos(t){return Number.isFinite(t)?cl.format(Math.round(t)):"—"},bp(t){return Number.isFinite(t)?Math.abs(t)>=1e6?`${(t/1e6).toFixed(2)} Mb`:Math.abs(t)>=1e3?`${(t/1e3).toFixed(1)} kb`:`${eA.format(t)} bp`:"—"},bytes(t){if(!Number.isFinite(t))return"—";const e=["B","kB","MB","GB","TB"];let n=t,A=0;for(;n>=1e3&&A<e.length-1;)n/=1e3,A++;return`${A===0?n:n.toFixed(1)} ${e[A]}`}};function ll(t){return!Number.isFinite(t)||t<=0?"—":t>=1e6?`${nA(t/1e6)} Mb`:t>=1e3?`${nA(t/1e3)} kb`:`${nA(t)} bp`}function nA(t){return String(Number(t.toFixed(2)))}function nt(t,e){const n=fl(t),A=hl(n,e);if(A===null)return n;throw new Rt("format",`The ${e.field} of this ${e.format} reads ${BA(t)}, ${A.reason}. `+de,{format:e.format,field:e.field,value:typeof t=="bigint"?t.toString():t,ceiling:e.ceiling,...e.available===void 0?{}:{available:e.available},...A.most===void 0?{}:{most:A.most}})}function ss(t,e,n){const A={format:n.format,field:n.field,offset:t,length:e,size:n.size};if(!QA(t)||!QA(e))throw new Rt("format",`The ${n.field} of this ${n.format} points at ${BA(e)} bytes from byte ${BA(t)}, which is not a place in a file. ${de}`,A);if(n.ceiling!==void 0&&e>n.ceiling)throw new Rt("format",`The ${n.field} of this ${n.format} is ${G.int(e)} bytes long, more than the ${G.int(n.ceiling)} any real one holds. ${de}`,{...A,ceiling:n.ceiling});if(t+e>n.size)throw new Rt("format",`The ${n.field} of this ${n.format} points at bytes ${G.int(t)} to ${G.int(t+e)}, past the end of a file of ${G.int(n.size)}. ${de}`,A)}const js=65536,Po=2**29;async function rs(t,e){if(typeof DecompressionStream>"u")throw new Rt("unsupported",`Reading a ${e.format} needs DecompressionStream, which this runtime does not have. 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-`,g);N<0&&(N=f);let k=N;k>g&&t.charCodeAt(k-1)===13&&k--;const b=t.slice(g,k);if(g=N+1,b.startsWith(`${cr} `)){const x=b.slice(cr.length+1).trim().split(/\s+/),[Y,...J]=x;if(Y==="PLACEMENT")s=Number(J[0]);else if(Y==="FRAME"&&J.length===4){const[K,V,H,ht]=J.map(Number);[K,V,H].every(Number.isFinite)&&ht>0&&(r={cx:K,cy:V,cz:H,factor:ht})}else if(Y==="WIDTH"){const K=Number(J[0]);Number.isInteger(K)&&K>0&&(o=K)}else if(Y==="HAPLOTYPES")i=J.map(sA);else if(Y==="CHAIN"&&J.length>=6){const K=Number(J[2]),V=Number(J[3]);en(K)&&en(V)&&K<=V&&n.push({first:K,last:V,hap:sA(J[4]),sequence:sA(J.slice(5).join(" "))})}else if(Y==="RUN"&&J.length===4){const[K,V,H,ht]=J.map(Number);en(K)&&Number.isInteger(V)&&V>0&&K+V-1<=fe&&Number.isInteger(H)&&H>=0&&Number.isInteger(ht)&&ht>0&&A.push({first:K,count:V,start:H,width:ht})}continue}if(l)continue;if(b.startsWith("ENDMDL")){l=!0;continue}if(!b.startsWith("HETATM")&&!b.startsWith("ATOM  "))continue;const D=Number(b.slice(6,11)),F=Number(b.slice(30,38)),R=Number(b.slice(38,46)),v=Number(b.slice(46,54));!en(D)||!Pg(F,R,v)||(b.slice(17,20)===Wg&&c++,a.push({serial:D,x:F,y:R,z:v}))}const h=e===""?"This file":e;if(a.length===0)throw new Error(`${h} has no ATOM or HETATM record with a place, so there is no bead to read.`);if(s===null||n.length===0||A.length===0)throw new Error(c===a.length?"These beads are named the way this app writes a PDB, but the lines that said where each one is on the genome are gone: PyMOL drops REMARK records when it saves. Open the PDB as this app wrote it, or its bed3d.":"A PDB says where each bead is in space and not where it is on the genome, and this one does not say: pastis and the other solvers write their beads in bin order and nothing else. Write the coordinates beside the bins they were modelled at, as a bed3d (chrom, start, end, x, y, z), and open that.");if(s!==lr)throw new Error(`This PDB's placement table is version ${String(s)}, and this reader understands version ${lr}.`);const u=new Int32Array(fe+1).fill(-1);n.forEach((N,k)=>{for(let b=N.first;b<=N.last;b++)u[b]=k});const I=new Float64Array(fe+1).fill(-1),d=new Float64Array(fe+1);for(const N of A)for(let k=0;k<N.count;k++)I[N.first+k]=N.start+k*N.width,d[N.first+k]=N.width;const C=i??[],E=new Map;C.forEach((N,k)=>E.set(N,k));const B=r??{cx:0,cy:0,cz:0,factor:1},Q=new Uint8Array(fe+1),m=[];for(const N of a){const k=u[N.serial],b=I[N.serial];if(k<0||b<0||Q[N.serial]===1)continue;Q[N.serial]=1;const D=n[k];E.has(D.hap)||(E.set(D.hap,C.length),C.push(D.hap)),m.push({contig:D.sequence,start:b,end:b+d[N.serial],xyz:[N.x/B.factor+B.cx,N.y/B.factor+B.cy,N.z/B.factor+B.cz],hap:D.hap})}if(m.length===0)throw new Error(`${h} has a placement table, and it places none of the file's ${G.int(a.length)} atoms.`);const p=C.length>1,w=new et;for(const N of m)w.add(N.contig,N.start,N.end,{xyz:N.xyz,hap:E.get(N.hap)??0,detail:p?`${hs} ${N.hap}`:""});const y={width:o??zg(m.map(N=>N.end-N.start)),haplotypes:C};return w.finish(null,y)}function en(t){return Number.isInteger(t)&&t>=1&&t<=fe}function sA(t){try{return decodeURIComponent(t)}catch{return t}}function zg(t){const e=new Map;for(const s of t)s>0&&e.set(s,(e.get(s)??0)+1);let n=0,A=1;for(const[s,r]of e)(r>n||r===n&&s<A)&&(n=r,A=s);return A}const rA="MessagePack value",gr=64,Xg=BigInt(Number.MAX_SAFE_INTEGER),Vg=BigInt(Number.MIN_SAFE_INTEGER);function yi(t,e=0){const n=new Zg(t,e);return{value:n.next(),end:n.at}}class Zg{constructor(e,n){this.bytes=e,this.at=n,this.view=new DataView(e.buffer,e.byteOffset,e.byteLength)}at;view;decoder=new TextDecoder;depth=0;next(){const e=this.u8();if(e<=127)return e;if(e>=224)return e-256;if(e>=128&&e<=143)return this.map(e&15);if(e>=144&&e<=159)return this.array(e&15);if(e>=160&&e<=191)return this.str(e&31);switch(e){case 192:return null;case 194:return!1;case 195:return!0;case 196:return this.bin(this.u8());case 197:return this.bin(this.u16());case 198:return this.bin(this.u32());case 202:return this.f32();case 203:return this.f64();case 204:return this.u8();case 205:return this.u16();case 206:return this.u32();case 207:return this.big(this.view.getBigUint64(this.take(8)));case 208:return this.i8();case 209:return this.i16();case 210:return this.i32();case 211:return this.big(this.view.getBigInt64(this.take(8)));case 217:return this.str(this.u8());case 218:return this.str(this.u16());case 219:return this.str(this.u32());case 220:return this.array(this.u16());case 221:return this.array(this.u32());case 222:return this.map(this.u16());case 223:return this.map(this.u32());default:throw new Error(`msgpack: unsupported type byte 0x${e.toString(16).padStart(2,"0")} at offset ${this.at-1}.`)}}take(e){const n=this.at;if(n+e>this.bytes.length)throw new Error(`msgpack: truncated: needed ${e} byte${e===1?"":"s"} at offset ${n} of ${this.bytes.length}.`);return this.at=n+e,n}u8(){return this.view.getUint8(this.take(1))}u16(){return this.view.getUint16(this.take(2))}u32(){return this.view.getUint32(this.take(4))}i8(){return this.view.getInt8(this.take(1))}i16(){return this.view.getInt16(this.take(2))}i32(){return this.view.getInt32(this.take(4))}f32(){return this.view.getFloat32(this.take(4))}f64(){return this.view.getFloat64(this.take(8))}big(e){if(e>Xg||e<Vg)throw new Error(`msgpack: the 64-bit integer ${e} at offset ${this.at-9} does not fit a JavaScript number.`);return Number(e)}str(e){const n=this.take(e);return this.decoder.decode(this.bytes.subarray(n,n+e))}bin(e){const n=this.take(e);return this.bytes.subarray(n,n+e)}open(e,n,A){if(this.depth>=gr)throw new Rt("format",`This ${rA} nests deeper than ${gr} levels at offset ${this.at}, which no document this reader opens does. The file is corrupt, or not the format its first bytes claim.`,{format:rA,offset:this.at,depth:this.depth});return this.depth++,nt(e,{format:rA,field:`${n} length at offset ${this.at}`,ceiling:2**32-1,available:this.bytes.length-this.at,bytesPerItem:A})}array(e){const n=this.open(e,"array",1),A=new Array(n);for(let s=0;s<n;s++)A[s]=this.next();return this.depth--,A}map(e){const n=this.open(e,"map",2),A=new Map;for(let s=0;s<n;s++){const r=this.at,o=this.next();if(typeof o!="string"&&typeof o!="number")throw new Error(`msgpack: a map key at offset ${r} is neither a string nor an integer.`);A.set(o,this.next())}return this.depth--,A}}const fr=64e3,yn="binary g3d",Ni={ratio:64,floor:64<<20,ceiling:1<<30},jg=[165,109,97,103,105,99],tf=[163,71,51,68];function Is(t){if(t.length===0)return!1;const e=t[0];let n;if(e>=128&&e<=143)n=1;else if(e===222)n=3;else return!1;const A=[...jg,...tf];if(t.length<n+A.length)return!1;for(let s=0;s<A.length;s++)if(t[n+s]!==A[s])return!1;return!0}async function ef(t,e){const n=e===void 0?fr:Math.min(fr,e),A=await t(n,0);if(!Is(A))throw new Error("Not a binary g3d: the file does not begin with the G3D magic.");const{value:s}=yi(A);if(!(s instanceof Map))throw new Error("Not a binary g3d: the header is not a map.");if(s.get("magic")!=="G3D")throw new Error('Not a binary g3d: the magic is not "G3D".');const r=s.get("version");if(r!==2)throw r===1?new Error("This is a version-1 g3d, written by a g3dtools older than 0.2. Run `g3dtools load` over the original text to rewrite it as a version-2 file, which is the layout this reader and the WashU browser both understand."):new Error(`Unsupported g3d version ${String(r)}: this reader understands version 2.`);const o=xe(s.get("resolutions"),"resolutions"),i=rf(s.get("categories"),"categories"),a=s.get("offsets");if(!(a instanceof Map))throw new Error("This g3d has no offsets map in its header.");const c=new Map;for(const[l,g]of a){const f=typeof l=="number"?l:Number(l);if(!Number.isInteger(f)||!(g instanceof Map))continue;const h=g.get("offset"),u=g.get("size");if(typeof h!="number"||typeof u!="number")continue;const I=`${f} bp block`;nt(h,{format:yn,field:`offset of the ${I}`,ceiling:Number.MAX_SAFE_INTEGER}),nt(u,{format:yn,field:`size of the ${I}`,ceiling:Ni.ceiling}),c.set(f,{offset:h,size:u})}for(const l of o)if(!c.has(l))throw new Error(`This g3d lists a resolution of ${l} bp but has no block for it.`);return{version:r,genome:typeof s.get("genome")=="string"?s.get("genome"):"",name:typeof s.get("name")=="string"?s.get("name"):"",resolutions:o,categories:i,offsets:c,...e===void 0?{}:{fileSize:e}}}async function nf(t,e,n){const A=e.offsets.get(n);if(A===void 0)throw new Error(`This g3d has no model at ${n} bp; it has ${e.resolutions.join(", ")}.`);e.fileSize!==void 0&&ss(A.offset,A.size,{format:yn,field:`${n} bp block`,size:e.fileSize});const s=await t(A.size,A.offset);if(s.length!==A.size)throw new Error(`The ${n} bp block of this g3d is ${s.length} bytes where the header promised ${A.size}.`);const{value:r}=yi(await sf(s,n));if(!(r instanceof Map))throw new Error(`The ${n} bp block of this g3d is not a map.`);const o=[...e.categories],i=o.length>1,a=new et;for(const[l,g]of r){const f=String(l);let h=o.indexOf(f);h<0&&(h=o.length,o.push(f));const u=i?`${hs} ${f}`:"";if(g instanceof Map)for(const[I,d]of g){if(!(d instanceof Map))continue;const C=`${f}/${String(I)} at ${n} bp`,E=xe(d.get("start"),`start of ${C}`),B=xe(d.get("x"),`x of ${C}`),Q=xe(d.get("y"),`y of ${C}`),m=xe(d.get("z"),`z of ${C}`);if(B.length!==E.length||Q.length!==E.length||m.length!==E.length)throw new Error(`The columns of ${C} in this g3d are not the same length.`);const p=String(I);for(let w=0;w<E.length;w++)a.add(p,E[w],E[w]+n,{xyz:[B[w],Q[w],m[w]],hap:h,detail:u})}}const c={width:n,haplotypes:o};return a.finish(null,c)}function Af(t){const e=t.resolutions.length,n=t.categories.length;return["binary g3d",`${e} resolution${e===1?"":"s"}`,`${n} categor${n===1?"y":"ies"}`].join(ct)}async function sf(t,e){return rs(t,{format:yn,field:`${e} bp block`,encoding:"deflate",maxBytes:gl(t.byteLength,Ni)})}function xe(t,e){if(!Array.isArray(t))throw new Error(`This g3d's ${e} is not an array.`);for(const n of t)if(typeof n!="number")throw new Error(`This g3d's ${e} holds a value that is not a number.`);return t}function rf(t,e){if(!Array.isArray(t))throw new Error(`This g3d's ${e} is not an array.`);for(const n of t)if(typeof n!="string")throw new Error(`This g3d's ${e} holds a value that is not a string.`);return t}const of=[66,65,73,1],af=[67,83,73,1],cf=14,lf=5,gf=37450,Qt="BAM index",ff=65536,hf=65536,uf=10,If=63,he=2**31-1;function hr(t,e){return t.length<e.length?!1:e.every((n,A)=>t[A]===n)}async function df(t){const e=We(t)?await Ot(t):t,n=hr(e,af)?Qf:hr(e,of)?Cf:null;if(n===null)throw new Error("This is not a BAM index: the magic bytes are neither BAI\\1 nor CSI\\1.");try{return n(e)}catch(A){throw A instanceof RangeError?new Rt("format",`This ${Qt} ends part-way through its own tables, ${e.byteLength.toLocaleString("en-US")} bytes in. It is truncated; rebuild it with \`samtools index\`.`,{bytes:e.byteLength}):A}}function Cf(t){const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=o=>t.byteLength-o,A=nt(e.getInt32(4,!0),{format:Qt,field:"reference count",ceiling:he,available:n(8),bytesPerItem:8});let s=8;const r=[];for(let o=0;o<A;o++){const i=new Map,a=nt(e.getInt32(s,!0),{format:Qt,field:`bin count of reference ${o}`,ceiling:ff,available:n(s+4)-4,bytesPerItem:8});s+=4;for(let g=0;g<a;g++){const f=e.getUint32(s,!0);s+=4;const h=nt(e.getInt32(s,!0),{format:Qt,field:`chunk count of bin ${f}`,ceiling:he,available:n(s+4),bytesPerItem:16});s+=4;const u=[];for(let I=0;I<h;I++)u.push({begin:e.getBigUint64(s,!0),end:e.getBigUint64(s+8,!0)}),s+=16;f!==gf&&i.set(f,u)}const c=nt(e.getInt32(s,!0),{format:Qt,field:`linear index size of reference ${o}`,ceiling:hf,available:n(s+4),bytesPerItem:8});s+=4;const l=new BigUint64Array(c);for(let g=0;g<c;g++)l[g]=e.getBigUint64(s,!0),s+=8;r.push({bins:i,linear:l,loffset:null})}return{format:"bai",minShift:cf,depth:lf,refs:r}}function Qf(t){const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=c=>t.byteLength-c,A=nt(e.getInt32(8,!0),{format:Qt,field:"CSI depth",ceiling:uf}),s=nt(e.getInt32(4,!0),{format:Qt,field:"CSI min_shift",ceiling:If-3*A});let o=16+nt(e.getInt32(12,!0),{format:Qt,field:"auxiliary data length",ceiling:he,available:n(16)-4});const i=nt(e.getInt32(o,!0),{format:Qt,field:"reference count",ceiling:he,available:n(o+4),bytesPerItem:4});o+=4;const a=[];for(let c=0;c<i;c++){const l=new Map,g=new Map,f=nt(e.getInt32(o,!0),{format:Qt,field:`bin count of reference ${c}`,ceiling:he,available:n(o+4),bytesPerItem:16});o+=4;for(let h=0;h<f;h++){const u=e.getUint32(o,!0);o+=4,g.set(u,e.getBigUint64(o,!0)),o+=8;const I=nt(e.getInt32(o,!0),{format:Qt,field:`chunk count of bin ${u}`,ceiling:he,available:n(o+4),bytesPerItem:16});o+=4;const d=[];for(let C=0;C<I;C++)d.push({begin:e.getBigUint64(o,!0),end:e.getBigUint64(o+8,!0)}),o+=16;l.set(u,d)}a.push({bins:l,linear:null,loffset:g})}return{format:"csi",minShift:s,depth:A,refs:a}}function $e(t,e){return Math.floor(t/2**e)}function Bf(t,e,n,A){const s=[],r=Math.max(e,n-1);let o=A.minShift+A.depth*3,i=0;for(let a=0;a<=A.depth;a++){const c=i+$e(e,o),l=i+$e(r,o);if(l-c+1>t.bins.size)for(const[g,f]of t.bins)g>=c&&g<=l&&s.push(f);else for(let g=c;g<=l;g++){const f=t.bins.get(g);f!==void 0&&s.push(f)}i+=1<<a*3,o-=3}return s}function Ef(t,e,n){if(t.linear!==null){const r=$e(e,n.minShift);return t.linear.length===0?0n:t.linear[Math.min(r,t.linear.length-1)]}if(t.loffset===null)return 0n;let A=n.minShift,s=0;for(let r=n.depth;r>=0;r--){s=ki(r);const o=t.loffset.get(s+$e(e,A));if(o!==void 0)return o;A+=3}return 0n}function ki(t){let e=0;for(let n=0;n<t;n++)e+=1<<n*3;return e}function mf(t,e,n){let A=null,s=n.minShift;for(let r=n.depth;r>=0;r--){const o=ki(r),i=1<<r*3,a=$e(Math.max(0,e-1),s)+1;for(let c=0;c<8&&a+c<i;c++){const l=t.bins.get(o+a+c);if(l!==void 0)for(const g of l)(A===null||g.begin<A)&&(A=g.begin)}s+=3}return A??BigInt(Number.MAX_SAFE_INTEGER)<<16n}const wf=1<<20;function pf(t,e,n,A,s){const r=t.refs[e];if(r===void 0)return[];const o=Ef(r,Math.max(0,n),t),i=mf(r,Math.max(1,A),t),a=[];for(const l of Bf(r,Math.max(0,n),Math.max(1,A),t))for(const g of l)g.end>o&&g.begin<i&&a.push(g);if(a.length===0)return[];a.sort((l,g)=>l.begin<g.begin?-1:l.begin>g.begin?1:0);const c=[];for(const l of a){const g=Number(l.begin>>16n),f=Number(l.begin&0xffffn),h=Number(l.end>>16n),u=Math.min(s,h+Et),I=c[c.length-1];I!==void 0&&g<=I.to+wf?(I.to=Math.max(I.to,u),I.lastBlock=Math.max(I.lastBlock,h)):c.push({from:g,to:u,lastBlock:h,dataFrom:f})}return c}function bi(t){let e=0;for(const n of t)e+=n.to-n.from;return e}const yf=2*Et,Nf=Et,ur=1<<20,kf=4*Et,bf=16384,Df=1<<24,Mf=1<<18,Ff=1<<24,Nn=18,Pt=[31,139,8,4],me=36;function jt(t,e){return t<0?Number.POSITIVE_INFINITY:t*2**32+e+1}class yA extends Error{constructor(e,n){super("The reads are not in coordinate order."),this.before=e,this.after=n,this.name="UnsortedError"}}function Ir(t,e){return t.refId<0?"unplaced":`${e[t.refId]?.name??`reference ${t.refId}`}:${(t.pos+1).toLocaleString("en-US")}`}function Sf(t,e){const n=e-1;return t>>14===n>>14?32767/7+(t>>14):t>>17===n>>17?4095/7+(t>>17):t>>20===n>>20?511/7+(t>>20):t>>23===n>>23?63/7+(t>>23):t>>26===n>>26?7/7+(t>>26):0}class ds{constructor(e,n,A,s){this.handle=e,this.size=n,this.refs=A,this.progress=s,this.lineStart=[];let r=0;for(const o of A)this.lineStart.push(r),r+=Math.max(0,o.length);this.lineLength=r}probes=[];answers=new Map;probing=new Map;lastWalk=null;walking=new Map;bytesRead=0;first=null;lineStart;lineLength;static async open(e,n,A,s,r){const o=new ds(e,n,A.refs,s);if(o.first=await o.firstRecord(A.recordsFrom),o.first!==null&&A.sortOrder!=="coordinate")for(const i of[.125,.375,.625,.875])r!==void 0&&await r(),await o.probeAt(Math.floor(n*i));return o}get bytes(){return this.bytesRead}get probeCount(){return this.probes.length}async spansFor(e,n,A,s,r){if(this.first===null||A<=n)return[];const o=await this.locate(e,Math.max(0,n-bf),s);if(o===null||o.key>=jt(e,A))return[];if(r!==void 0&&o.block+r<this.size){s!==void 0&&await s();const c=await this.probeAt(dr(o.block+r,o.block));if(c.key<jt(e,A)){const l=c.block;return[{from:o.block,to:Math.min(this.size,l+Et),lastBlock:l,dataFrom:o.within}]}}const i=await this.locate(e,A,s),a=i===null||i.tail===!0?this.size:i.block;return[{from:o.block,to:Math.min(this.size,a+Et),lastBlock:a,dataFrom:o.within}]}locate(e,n,A){if(this.first===null)return Promise.resolve(null);const s=jt(e,n);if(this.first.key>=s)return Promise.resolve(this.first);const r=this.answers.get(s);if(r!==void 0)return r;const o=this.search(e,n,A).then(i=>(i!==null&&i.tail!==!0&&this.remember(i,!0),i));return this.answers.set(s,o),o.catch(()=>this.answers.delete(s)),o}async search(e,n,A){if(this.first===null)return null;const s=jt(e,n);let r=this.first,o=null;for(const c of this.probes)if(c.key<s)r=c;else{o=c;break}let i=!0;for(;;){const c=o===null?this.size:o.block,l=c-r.block;if(l<=kf)break;A!==void 0&&await A();const g=i?this.guess(r,o,e,n):null,f=await this.probeAt(dr(g??Math.floor((r.block+c)/2),r.block));if(f.block>=c)break;f.key>=s?o=f:r=f,i=(o===null?this.size:o.block)-r.block<=l/2}const a=o===null||o.tail===!0?this.size:Math.min(this.size,o.block+Et);return this.walk(r,a,s)}lineOf(e,n){return(this.lineStart[e]??this.lineLength)+Math.max(0,n)}guess(e,n,A,s){const r=this.lineOf(A,s),o=this.lineOf(e.refId,e.pos),i=n===null||n.tail===!0||n.refId<0?this.lineLength:this.lineOf(n.refId,n.pos);if(i<=o)return null;const a=(r-o)/(i-o);if(!(a>0&&a<1))return null;const c=n===null?this.size:n.block,l=e.block+Math.floor(a*(c-e.block));return Math.min(Math.max(l,e.block+1),c-2*Et)}async walk(e,n,A){if(n<=e.block)return null;let s=this.lastWalk;if(s===null||e.block<s.from||n>s.to){const c=`${e.block}-${n}`;let l=this.walking.get(c);if(l===void 0){l=this.read(n-e.block,e.block).then(async f=>{const{bytes:h,blocks:u}=await NA(f,e.block);return{from:e.block,to:n,bytes:h,blocks:u}}),this.walking.set(c,l);const g=()=>{this.walking.delete(c)};l.then(g,g)}s=await l,this.lastWalk=s}const{bytes:r,blocks:o}=s,i=o.find(c=>c.fileAt===e.block);if(i===void 0)return this.lastWalk=null,this.walk(e,n,A);let a=null;return wn(r,i.from+e.within,c=>jt(c.refId,c.pos)<A?!0:(a=kA(o,c.at-4,c.refId,c.pos),!1)),a}probeAt(e){const n=this.probing.get(e);if(n!==void 0)return n;const A=this.probe(e);this.probing.set(e,A);const s=()=>{this.probing.delete(e)};return A.then(s,s),A}async probe(e){let n=yf;for(;;){const A=Math.min(this.size,e+n);if(A<=e)return this.remember({block:e,within:0,refId:-1,pos:-1,key:Number.POSITIVE_INFINITY,tail:!0});const s=await this.read(A-e,e),r=await Lf(s,e,this.refs,this.size);if(r.kind==="record")return this.remember(r.placed);if(r.kind==="end"||A>=this.size)return this.remember({block:e,within:0,refId:-1,pos:-1,key:Number.POSITIVE_INFINITY,tail:!0});if(n>=ur)throw new Error(`no alignment record could be made out within ${ur>>20} MB of byte ${e.toLocaleString("en-US")}`);n*=4}}remember(e,n=!1){let A=this.probes.length;for(;A>0&&this.probes[A-1].block>e.block;)A--;const s=this.probes[A-1];if(s!==void 0&&s.block===e.block&&s.within===e.within)return s;if(n)return this.probes.splice(A,0,e),e;const r=A===0?this.first:this.probes[A-1],o=A<this.probes.length?this.probes[A]:null;if(r!==null&&r.key>e.key)throw new yA(r,e);if(o!==null&&e.key>o.key)throw new yA(e,o);return this.probes.splice(A,0,e),e}async firstRecord(e){let n=Mf;for(;;){const A=await this.read(Math.min(n,this.size),0);let s=0,r=0;for(;s+Nn<=A.length;){const o=ye(A.subarray(s,Math.min(s+64,A.length)));if(o===null||s+o>A.length)break;const i=Di(A,s+o-4);if(e<r+i){const{bytes:a,blocks:c}=await NA(A.subarray(s),s),l=e-r;if(l+me>a.length){if(A.length>=this.size)return null;break}if(!bA(a,l,this.refs))throw new Error("the first alignment record is not where the header says it begins");const g=new DataView(a.buffer,a.byteOffset,a.byteLength);return kA(c,l,g.getInt32(l+4,!0),g.getInt32(l+8,!0))}r+=i,s+=o}if(A.length>=this.size)return null;if(n>=Ff)throw new Error("the header does not end within the first 16 MB");n*=4}}async read(e,n){const A=await this.handle.read(e,n);return this.bytesRead+=A.length,this.progress!==void 0&&this.progress(this.bytesRead),A}}async function NA(t,e){const n=[],A=[];let s=0,r=0,o=!1;for(;r+Nn<=t.length;){const c=ye(t.subarray(r,Math.min(r+64,t.length)));if(c===null||r+c>t.length)break;const l=await Ot(t.subarray(r,r+c),0);l.length===0&&(o=!0),A.push({fileAt:e+r,from:s,to:s+l.length}),n.push(l),s+=l.length,r+=c}const i=new Uint8Array(s);let a=0;for(const c of n)i.set(c,a),a+=c.length;return{bytes:i,blocks:A,sawEnd:o}}function kA(t,e,n,A){for(const r of t)if(e>=r.from&&e<r.to)return{block:r.fileAt,within:e-r.from,refId:n,pos:A,key:jt(n,A)};const s=t[t.length-1];return{block:s.fileAt,within:e-s.from,refId:n,pos:A,key:jt(n,A)}}function Rf(t,e,n){for(let A=0;A+Nn<=t.length;A++){if(t[A]!==Pt[0]||t[A+1]!==Pt[1]||t[A+2]!==Pt[2]||t[A+3]!==Pt[3])continue;const s=ye(t.subarray(A,Math.min(A+64,t.length)));if(s===null||s>Et||s<Nn+8)continue;const r=A+s;if(r>t.length)return e+r===n?A:"more";if(!(Di(t,r-4)>Et)){if(e+r===n)return A;if(r+3<=t.length){if(t[r]===Pt[0]&&t[r+1]===Pt[1]&&t[r+2]===Pt[2])return A;continue}return"more"}}return"more"}async function Lf(t,e,n,A){const s=Rf(t,e,A);if(s==="more")return e+t.length>=A?{kind:"end"}:{kind:"more"};const{bytes:r,blocks:o,sawEnd:i}=await NA(t.subarray(s),e+s);if(r.length===0)return i||e+t.length>=A?{kind:"end"}:{kind:"more"};const a=xf(r,n);if(a>=0){const c=new DataView(r.buffer,r.byteOffset,r.byteLength);return{kind:"record",placed:kA(o,a,c.getInt32(a+4,!0),c.getInt32(a+8,!0))}}return 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d=0,C=0;wn(t,e,p=>{if(d++,p.refId===n&&(p.flag&o.exclude)===0&&!(p.mapq<o.minMapq)&&!(p.pos<0||p.end<=A||p.pos>=s)){if(C++,Kf(t,p,(w,y)=>{const N=Math.max(w,A),k=Math.min(y,s);k<=N||Br(f,h,(N-A)/g,(k-A)/g,r)}),a!==void 0){let w=null;Of(t,p,(y,N)=>{if(N<=A||y>=s)return;w??=_f(t,p);const k=`${y}:${N}:${w}`;a.set(k,(a.get(k)??0)+1)})}if(c!==void 0)for(const w of jo(t,p)){if(w.pos<A||w.pos>=s)continue;const y=Hl(w.prob,c.threshold);if(y<0)continue;let N=c.tally.get(w.code);N===void 0&&(N={calls:new Float64Array(r),modified:new Float64Array(r)},c.tally.set(w.code,N));const k=Math.min(r-1,Math.floor((w.pos-A)/g));N.calls[k]++,y===1&&N.modified[k]++}i===void 0||u===null||I===null||$f(t,p,i,w=>{w<A||w>=s||Br(u,I,(w-A)/g,(w+1-A)/g,r)},[A,s])}});let E=0,B=0;const Q=new Float32Array(r);for(let p=0;p<r;p++){E+=h[p];const w=E+f[p];Q[p]=w,w>B&&(B=w)}let m=null;if(u!==null&&I!==null){m=new Float32Array(r);let p=0;for(let w=0;w<r;w++)p+=I[w],m[w]=p+u[w]}return{depth:Q,variant:m,total:d,kept:C,max:B}}function $f(t,e,n,A,s=[Number.NEGATIVE_INFINITY,Number.POSITIVE_INFINITY]){const r=new DataView(t.buffer,t.byteOffset,t.byteLength),o=Pe(t,e),i=o===null?e.cigarOps:o.length,a=f=>o===null?r.getUint32(e.cigarAt+f*4,!0):o[f],c=n.start+n.bases.length;let l=e.pos,g=0;for(let f=0;f<i;f++){const h=a(f),u=h&15,I=h>>>4;if(u===2){const d=Math.max(0,s[0]-l),C=Math.min(I,s[1]-l);for(let E=d;E<C;E++)A(l+E);l+=I;continue}if(mt(u)&&Yt(u)){const d=Math.max(0,n.start-l,s[0]-l),C=Math.min(I,c-l,s[1]-l,e.seqLength-g);for(let E=d;E<C;E++){const B=l+E-n.start,Q=Ne[n.bases[B]];if(Q===4)continue;const m=Yf(t,e.seqAt,g+E);m!==4&&m!==Q&&A(l+E)}l+=I,g+=I;continue}mt(u)&&(l+=I),Yt(u)&&(g+=I)}}function Yf(t,e,n){const A=t[e+(n>>1)],s=n%2===0?A>>4:A&15;return Ne[as.charCodeAt(s)]}function Br(t,e,n,A,s){const r=Math.min(s-1,Math.max(0,Math.floor(n))),o=Math.min(s-1,Math.max(0,Math.ceil(A)-1));if(!(o<r)){if(r===o){t[r]+=Math.min(A,r+1)-Math.max(n,r);return}t[r]+=r+1-Math.max(n,r),t[o]+=Math.min(A,o+1)-o,o>r+1&&(e[r+1]+=1,e[o]-=1)}}function Of(t,e,n){const A=Pe(t,e),s=A===null?e.cigarOps:A.length,r=A===null?new DataView(t.buffer,t.byteOffset,t.byteLength):null;let o=e.pos;for(let i=0;i<s;i++){const a=r===null?A[i]:r.getUint32(e.cigarAt+i*4,!0),c=a&15,l=a>>>4;if(c===3){l>0&&n(o,o+l),o+=l;continue}mt(c)&&(o+=l)}}function _f(t,e){let A=e.seqAt+(e.seqLength+1>>1)+e.seqLength;const s=e.at+e.bytes-4;for(;A+3<=s;){const r=t[A],o=t[A+1],i=String.fromCharCode(t[A+2]);if(A+=3,i==="A"&&(r===88&&o===83||r===116&&o===115)){const a=t[A]===43?1:t[A]===45?-1:0;return r===88?a:(e.flag&At.REVERSE)!==0?-a:a}if(A=is(t,A,i,s),A<0)return 0}return 0}function Kf(t,e,n){const A=new DataView(t.buffer,t.byteOffset,t.byteLength),s=Pe(t,e),r=s===null?e.cigarOps:s.length,o=l=>s===null?A.getUint32(e.cigarAt+l*4,!0):s[l];let i=e.pos,a=e.pos,c=!1;for(let l=0;l<r;l++){const g=o(l),f=g&15,h=g>>>4;if(f===3){c&&i>a&&n(a,i),c=!1,i+=h,a=i;continue}mt(f)&&(c||(a=i,c=!0),i+=h)}c&&i>a&&n(a,i)}function qf(t,e,n){let A=2166136261;for(let s=e;s<n;s++)A^=t[s],A=Math.imul(A,16777619)>>>0;return A/4294967296}function Hf(t,e,n,A,s,r,o){const i=new DataView(t.buffer,t.byteOffset,t.byteLength),a=o.filter;let c=0;const l=[];wn(t,e,C=>{Er(C,A,s,r,a)&&(c++,l.push(qf(t,C.at+32,C.at+32+C.nameBytes-1)))});const g=Math.max(1,Math.min(o.maxReads,o.maxRows*Wf)),f=c<=g?1:g/c,h=f<1,u=[],I=[];let d=0;return wn(t,e,C=>{!Er(C,A,s,r,a)||l[d++]>=f||I.push(Pf(t,i,C,o,u))}),{pile:nh(I,n,A,s,r,o),total:c,kept:I.length,capped:h,rows:u.length,usedMd:I.some(C=>C.fromMd),usedCigar:I.some(C=>C.fromCigar)}}const Wf=8;function Er(t,e,n,A,s){return t.refId!==e||(t.flag&s.exclude)!==0||t.mapq<s.minMapq?!1:t.pos>=0&&t.end>n&&t.pos<A}function Pf(t,e,n,A,s){const r=Pe(t,n),o=r===null?n.cigarOps:r.length,i=h=>r===null?e.getUint32(n.cigarAt+h*4,!0):r[h],a=[];let c=0,l=0;for(let h=0;h<o;h++){const u=i(h);a.push(u);const I=u&15,d=u>>>4;I===4&&(h===0||h===1&&(i(0)&15)===5?c=d:(h===o-1||h===o-2&&(i(o-1)&15)===5)&&(l=d))}const g=Vf(t,n,a,A.reference),f=Xf(s,n.pos-c,n.end+l);return{refStart:n.pos,refEnd:n.end,clipStart:c,clipEnd:l,row:f,flag:n.flag,mapq:n.mapq,mateContig:n.nextRefId,matePos:n.nextPos,tlen:n.tlen,name:Rl(t,n),ops:a,diffPos:g.pos,diffBase:g.base,fromMd:g.fromMd,fromCigar:g.fromCigar,mods:A.colourBy==="basemod"?jo(t,n,a):null}}const zf=3;function Xf(t,e,n){for(let A=0;A<t.length;A++)if(t[A]+zf<=e)return t[A]=n,A;return t.push(n),t.length-1}function MA(t,e,n){const A=t[e+(n>>1)],s=n%2===0?A>>4:A&15;return Ne[as.charCodeAt(s)]}function Vf(t,e,n,A){const s={pos:[],base:[],fromMd:!1,fromCigar:!1};if(n.some(o=>(o&15)===8)){let o=e.pos,i=0;for(const a of n){const c=a&15,l=a>>>4;if(c===8){const g=Math.min(l,e.seqLength-i);for(let f=0;f<g;f++)s.pos.push(o+f),s.base.push(MA(t,e.seqAt,i+f))}mt(c)&&(o+=l),Yt(c)&&(i+=l)}return s.fromCigar=!0,s}const r=Zf(t,e);if(r!==null)return jf(t,e,n,r,s),s.fromMd=!0,s;if(A!==void 0){let o=e.pos,i=0;const a=A.start+A.bases.length;for(const c of n){const l=c&15,g=c>>>4;if(mt(l)&&Yt(l)){const f=Math.max(0,A.start-o),h=Math.min(g,a-o,e.seqLength-i);for(let u=f;u<h;u++){const I=o+u-A.start,d=Ne[A.bases[I]],C=MA(t,e.seqAt,i+u);d!==C&&d<4&&C<4&&(s.pos.push(o+u),s.base.push(C))}}mt(l)&&(o+=g),Yt(l)&&(i+=g)}}return s}function Zf(t,e){let A=e.seqAt+(e.seqLength+1>>1)+e.seqLength;const s=e.at+e.bytes-4;for(;A+3<=s;){const r=String.fromCharCode(t[A],t[A+1]),o=String.fromCharCode(t[A+2]);if(A+=3,r==="MD"&&o==="Z"){let i=A;for(;i<s&&t[i]!==0;)i++;return new TextDecoder().decode(t.subarray(A,i))}if(A=is(t,A,o,s),A<0)return null}return null}function jf(t,e,n,A,s){const r=[],o=[];let i=e.pos,a=0;for(const l of n){const g=l&15,f=l>>>4;if(mt(g)&&Yt(g)){const h=Math.min(f,e.seqLength-a);for(let u=0;u<h;u++)r.push(i+u),o.push(a+u)}mt(g)&&(i+=f),Yt(g)&&(a+=f)}let c=0;for(const l of A.match(/(\d+|\^[A-Za-z]+|[A-Za-z])/g)??[]){if(l.charCodeAt(0)===94)continue;const g=Number(l);if(Number.isFinite(g)&&l!==""){c+=g;continue}c<r.length&&(s.pos.push(r[c]),s.base.push(MA(t,e.seqAt,o[c]))),c+=1}}const Fi=1e3;function th(t,e,n){switch(e){case"strand":return(t.flag&At.REVERSE)!==0?1:0;case"mapq":return t.mapq===0?0:t.mapq<30?1:2;case"pair":return(t.flag&At.PAIRED)===0?0:(t.flag&At.PROPER_PAIR)!==0?1:2;case"mate":return(t.flag&At.PAIRED)===0?0:(t.flag&At.MATE_UNMAPPED)!==0||t.mateContig<0?1:t.mateContig===n?2:3;case"insert":{const A=Math.abs(t.tlen);return(t.flag&At.PAIRED)===0||A===0?0:A>Fi?2:1}default:return 0}}function eh(t){switch(t){case"strand":return["forward","reverse"];case"mapq":return["MAPQ 0","MAPQ < 30","MAPQ ≥ 30"];case"pair":return["unpaired","proper pair","not a proper pair"];case"mate":return["unpaired","mate unmapped","same sequence","another sequence"];case"insert":return["unpaired","ordinary insert",`insert > ${Fi}`];case"basemod":return["reads"];default:return["reads"]}}function nh(t,e,n,A,s,r){const o=t.length,i={contig:e,start:A,end:s,length:o,refStart:new Int32Array(o),refEnd:new Int32Array(o),clipStart:new Int32Array(o),clipEnd:new Int32Array(o),row:new Int16Array(o),flags:new Uint16Array(o),mapq:new Uint8Array(o),mateContig:new Int32Array(o),matePos:new Int32Array(o),tlen:new Int32Array(o),group:new Uint8Array(o),mate:new Int32Array(o).fill(-1),opAt:new Int32Array(o+1),opCode:new Uint8Array(t.reduce((l,g)=>l+g.ops.length,0)),opLen:new Int32Array(t.reduce((l,g)=>l+g.ops.length,0)),diffAt:new Int32Array(o+1),diffPos:new Int32Array(t.reduce((l,g)=>l+g.diffPos.length,0)),diffBase:new Uint8Array(t.reduce((l,g)=>l+g.diffPos.length,0)),contigs:[],groups:eh(r.colourBy),names:[]};let a=0,c=0;for(let l=0;l<o;l++){const g=t[l];i.refStart[l]=g.refStart,i.refEnd[l]=g.refEnd,i.clipStart[l]=g.clipStart,i.clipEnd[l]=g.clipEnd,i.row[l]=g.row,i.flags[l]=g.flag,i.mapq[l]=g.mapq,i.mateContig[l]=g.mateContig,i.matePos[l]=g.matePos,i.tlen[l]=g.tlen,i.opAt[l]=a;for(const f of g.ops)i.opCode[a]=f&15,i.opLen[a]=f>>>4,a++;i.diffAt[l]=c;for(let f=0;f<g.diffPos.length;f++)i.diffPos[c]=g.diffPos[f],i.diffBase[c]=g.diffBase[f],c++;r.withNames&&i.names.push(g.name)}i.opAt[o]=a,i.diffAt[o]=c,r.colourBy==="basemod"&&(i.mods=Ah(t));for(let l=0;l<o;l++)i.group[l]=th(t[l],r.colourBy,n);return sh(i,n,e,r),rh(i,t),i}function Ah(t){const e=new Map;let n=0;for(const i of t)for(const a of i.mods??[]){const c=e.get(a.code)??[0,0];a.prob>=128&&c[0]++,c[1]++,e.set(a.code,c),n++}const A=[...e.entries()].sort((i,a)=>a[1][0]-i[1][0]||a[1][1]-i[1][1]||(i[0]<a[0]?-1:1)),s=new Map(A.map(([i],a)=>[i,a])),r={at:new Int32Array(t.length+1),pos:new Int32Array(n),code:new Uint8Array(n),prob:new Uint8Array(n),codes:A.map(([i])=>i),counts:A.map(([,[i]])=>i)};let o=0;for(let i=0;i<t.length;i++){r.at[i]=o;for(const a of t[i].mods??[])r.pos[o]=a.pos,r.code[o]=s.get(a.code)??0,r.prob[o]=a.prob,o++}return r.at[t.length]=o,r}function sh(t,e,n,A){const s=new Map;for(let r=0;r<t.length;r++){const o=t.mateContig[r];if(o<0){t.mateContig[r]=-1;continue}let i=s.get(o);i===void 0&&(i=t.contigs.length,t.contigs.push(o===e?n:A.refNameOf?.(o)??""),s.set(o,i)),t.mateContig[r]=i}}function rh(t,e){const n=new Map;for(let A=0;A<e.length;A++){const s=e[A].name;if(s===""||(t.flags[A]&At.SUPPLEMENTARY)!==0)continue;const r=n.get(s);if(r===void 0){n.set(s,A);continue}t.mate[r]===-1&&t.mate[A]===-1&&((t.flags[r]^t.flags[A])&(At.FIRST_IN_PAIR|At.SECOND_IN_PAIR))!==0&&(t.mate[r]=A,t.mate[A]=r)}}function Si(t){const e=t.split(`
-`,200);let n=0;for(const A of e){const s=A.trim();if(s==="")continue;if(/^(fixedStep|variableStep)\b/i.test(s))return"wig";if(/^track\b/i.test(s)){if(/type\s*=\s*"?bedGraph/i.test(s))return"bedgraph";if(/type\s*=\s*"?wiggle_0/i.test(s))return"wig";continue}if(s.startsWith("#")||/^browser\b/i.test(s))continue;const r=s.split(/\t| +/);if(r.length!==4||!S(r[1])||!S(r[2]))return null;const o=Number(r[3]);if(!Number.isFinite(o)||r[3].trim()==="")return null;if(n+=1,n>=4)return"bedgraph"}return n>0?"bedgraph":null}class Cs{constructor(e){this.name=e}starts=[];ends=[];values=[];push(e,n,A){this.starts.push(e),this.ends.push(n),this.values.push(A)}get length(){return this.starts.length}finish(){const e=this.starts.length,n=Int32Array.from({length:e},(i,a)=>a);let A=!0;for(let i=1;i<e;i++)if(this.starts[i]<this.starts[i-1]){A=!1;break}A||n.sort((i,a)=>this.starts[i]-this.starts[a]);const s=new Int32Array(e),r=new Int32Array(e),o=new Float32Array(e);for(let i=0;i<e;i++){const a=n[i];s[i]=this.starts[a],r[i]=this.ends[a],o[i]=this.values[a]}return{name:this.name,starts:s,ends:r,values:o}}}function Ri(t){const e=new Map;let n=Number.POSITIVE_INFINITY,A=Number.NEGATIVE_INFINITY,s=0;for(const r of t.split(`
-`)){const o=r.trim();if(o===""||o.startsWith("#")||/^(track|browser)\b/i.test(o))continue;const i=o.split(/\t| +/);if(i.length<4)continue;const a=Number(i[1]),c=Number(i[2]),l=Number(i[3]);if(!Number.isInteger(a)||!Number.isInteger(c)||!Number.isFinite(l)||c<=a)continue;let g=e.get(i[0]);g===void 0&&(g=new Cs(i[0]),e.set(i[0],g)),g.push(a,c,l),s+=1,l<n&&(n=l),l>A&&(A=l)}return Qs(e,s,n,A)}function Li(t){const e=new Map;let n=Number.POSITIVE_INFINITY,A=Number.NEGATIVE_INFINITY,s=0,r=null,o="",i=1,a=1,c=0,l=null;const g=(f,h)=>{l===null||!Number.isFinite(h)||(l.push(f,f+i,h),s+=1,h<n&&(n=h),h>A&&(A=h))};for(const f of t.split(`
-`)){const h=f.trim();if(h===""||h.startsWith("#")||/^(track|browser)\b/i.test(h))continue;const u=/^(fixedStep|variableStep)\s+(.*)$/i.exec(h);if(u!==null){r=u[1].toLowerCase()==="fixedstep"?"fixed":"variable";const I=new Map;for(const d of u[2].split(/\s+/)){const C=d.indexOf("=");C>0&&I.set(d.slice(0,C).toLowerCase(),d.slice(C+1))}if(o=I.get("chrom")??"",i=Number(I.get("span")??1)||1,a=Number(I.get("step")??1)||1,c=(Number(I.get("start")??1)||1)-1,o===""){l=null;continue}l=e.get(o)??new Cs(o),e.set(o,l);continue}if(!(r===null||l===null))if(r==="fixed")g(c,Number(h)),c+=a;else{const I=h.split(/\t| +/);if(I.length<2)continue;const d=Number(I[0]);if(!Number.isInteger(d))continue;g(d-1,Number(I[1]))}}return Qs(e,s,n,A)}function Qs(t,e,n,A){const s=[];for(const r of t.values())r.length>0&&s.push(r.finish());return{contigs:s,length:e,min:Number.isFinite(n)?n:0,max:Number.isFinite(A)?A:0}}class xi{constructor(e){this.set=e;for(const n of e.contigs)this.byName.set(n.name,n)}byName=new Map;held(e){const n=this.byName.get(e);if(n!==void 0)return n;const A=Kt(this.set.contigs,e);return A<0?void 0:this.set.contigs[A]}get contigNames(){return this.set.contigs.map(e=>e.name)}get extent(){return{min:this.set.min,max:this.set.max}}get length(){return this.set.length}has(e){return this.held(e)!==void 0}samples(e,n,A,s){const r=this.held(e);if(r===void 0||A<=n)return null;const o=oh(r.ends,n);let i=o;for(;i<r.starts.length&&r.starts[i]<A;)i+=1;if(i<=o)return{starts:new Int32Array(0),ends:new Int32Array(0),values:new Float32Array(0),min:null,max:null,summary:!1};const a=Math.max(1,s),c=Math.ceil((A-n)/a);if(i-o<=c)return{starts:r.starts.slice(o,i),ends:r.ends.slice(o,i),values:r.values.slice(o,i),min:null,max:null,summary:!1};const l=new Int32Array(c),g=new Int32Array(c),f=new Float32Array(c),h=new Float32Array(c),u=new Float32Array(c),I=new Float64Array(c),d=new Float64Array(c);h.fill(Number.NaN),u.fill(Number.NaN);for(let C=0;C<c;C++)l[C]=Math.round(n+C*a),g[C]=Math.round(Math.min(A,n+(C+1)*a));for(let C=o;C<i;C++){const E=Math.max(r.starts[C],n),B=Math.min(r.ends[C],A);if(B<=E)continue;const Q=r.values[C],m=Math.max(0,Math.floor((E-n)/a)),p=Math.min(c-1,Math.floor((B-1-n)/a));for(let w=m;w<=p;w++){const y=Math.min(B,g[w])-Math.max(E,l[w]);y<=0||(d[w]+=Q*y,I[w]+=y,(Number.isNaN(h[w])||Q<h[w])&&(h[w]=Q),(Number.isNaN(u[w])||Q>u[w])&&(u[w]=Q))}}for(let C=0;C<c;C++)f[C]=I[C]>0?d[C]/I[C]:Number.NaN;return{starts:l,ends:g,values:f,min:h,max:u,summary:!0}}}function oh(t,e){let n=0,A=t.length;for(;n<A;){const s=n+A>>1;t[s]<=e?n=s+1:A=s}return n}const ih=1<<18,ah=64<<20;class mr extends Do{constructor(e,n,A=ih,s=ah){super(e,n),this.chunkBytes=A,this.budgetBytes=s}chunks=new Map;inflight=new Map;held=0;end=null;fetched=0;requests=0;async read(e,n,A){if(e<=0||this.end!==null&&n>=this.end)return new Uint8Array(0);const s=Math.floor(n/this.chunkBytes),r=Math.floor((n+e-1)/this.chunkBytes),o=[];let i=null;const 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C=Math.max(g.start,f.starts[I]),E=Math.min(g.end,f.ends[I]);E<=C||(h+=d*(E-C),u+=E-C)}s.push({contig:g.contig,start:g.start,end:g.end,name:n.name[o[l]]??"",signal:h,mean:u>0?h/u:Number.NaN})}}return s}function Jh(t,e){return{contig:t.contigs[t.contig[e]],start:t.start[e],end:t.end[e]}}function Dn(t){return`${t.contig}:${t.start}-${t.end}`}function $h(t){return .5*Yh(-t/Math.SQRT2)}function Yh(t){const e=Math.abs(t),n=e<2?1-Oh(e):_h(e);return t>=0?n:2-n}function Oh(t){let e=t,n=t;for(let A=1;A<200&&(e*=2*t*t/(2*A+1),n+=e,!(e<Math.abs(n)*1e-17));A++);return 2/Math.sqrt(Math.PI)*Math.exp(-t*t)*n}function _h(t){let n=1/t,A=1e300,s=n;for(let r=1;r<300;r++){const o=r/2;n=t+o*n,n===0&&(n=1e-300),A=t+o/A,A===0&&(A=1e-300),n=1/n;const i=A*n;if(s*=i,Math.abs(i-1)<1e-16)break}return Math.exp(-t*t)/Math.sqrt(Math.PI)*s}function Kh(t){const e=t.length,n=new Float64Array(e).fill(Number.NaN),A=[];for(let o=0;o<e;o++)Number.isFinite(t[o])&&A.push(o);A.sort((o,i)=>t[i]-t[o]);const s=A.length;let r=Number.POSITIVE_INFINITY;for(let o=0;o<s;o++){const i=s/(s-o);r=Math.min(r,i*t[A[o]]),n[A[o]]=Math.min(1,r)}return n}function Oi(t){return t.rows[1]<=t.rows[0]&&t.cols[1]<=t.cols[0]}function Ae(t){let e=0;for(let s=0;s<t.length;s++)Number.isFinite(t[s])&&e++;const n=new Float64Array(e);let A=0;for(let s=0;s<t.length;s++)Number.isFinite(t[s])&&(n[A++]=t[s]);return n.sort()}function Te(t,e){const n=t.length;if(n===0)return Number.NaN;const A=Math.min(n-1,Math.max(0,e*(n-1))),s=Math.floor(A),r=Math.min(n-1,s+1);return t[s]+(t[r]-t[s])*(A-s)}function qh(t){const e=Ae(t),n=e.length;if(n===0)return{n:0,mean:Number.NaN,sd:Number.NaN,median:Number.NaN,q1:Number.NaN,q3:Number.NaN};let A=0;for(let o=0;o<n;o++)A+=e[o];const s=A/n;let r=0;for(let o=0;o<n;o++)r+=(e[o]-s)**2;return{n,mean:s,sd:n>1?Math.sqrt(r/(n-1)):Number.NaN,median:Te(e,.5),q1:Te(e,.25),q3:Te(e,.75)}}function _i(t){const e=t.length,n=Array.from({length:e},(o,i)=>i).sort((o,i)=>t[o]-t[i]),A=new Float64Array(e);let 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h=0;h<g.length;h++)f+=o[r+h];a+=f*f/g.length,r+=g.length}a=12/(A*(A+1))*a-3*(A+1);const c=1-i/(A*A*A-A);if(!(c>0))return{h:Number.NaN,df:n-1,p:Number.NaN};const l=a/c;return{h:l,df:n-1,p:Ph(l,n-1)}}function Ph(t,e){return!(e>0)||Number.isNaN(t)?Number.NaN:t<=0?1:zh(e/2,t/2)}function zh(t,e){const n=Math.exp(-e+t*Math.log(e)-Ki(t));if(e<t+1){let a=1/t,c=a;for(let l=1;l<1e3&&(a*=e/(t+l),c+=a,!(Math.abs(a)<Math.abs(c)*1e-16));l++);return Math.max(0,1-c*n)}const A=1e-300;let s=e+1-t,r=1/A,o=1/s,i=o;for(let a=1;a<1e3;a++){const c=-a*(a-t);s+=2,o=c*o+s,Math.abs(o)<A&&(o=A),r=s+c/r,Math.abs(r)<A&&(r=A),o=1/o;const l=o*r;if(i*=l,Math.abs(l-1)<1e-16)break}return Math.min(1,n*i)}function Ki(t){if(t<.5)return Math.log(Math.PI/Math.sin(Math.PI*t))-Ki(1-t);const e=[.9999999999998099,676.5203681218851,-1259.1392167224028,771.3234287776531,-176.6150291621406,12.507343278686905,-.13857109526572012,9984369578019572e-21,15056327351493116e-23],n=t-1;let A=e[0];const s=n+7.5;for(let r=1;r<9;r++)A+=e[r]/(n+r);return .5*Math.log(2*Math.PI)+(n+.5)*Math.log(s)-s+Math.log(A)}const Xh=1e4,Mn=["#0072b2","#d55e00","#009e73","#cc79a7","#e69f00","#56b4e9","#f0e442","#000000"],Vh="#999999",kr="rest of the genome",ue=2e4,Zh=async t=>{const e=Yn(t.params,"tracks");if(e.length===0)return t.note("No track was chosen. Load a bigWig, or run a task that makes one, and tick it under Tracks."),[];const n=[];for(const[u,I]of Object.entries(t.inputs.contigLengths??{}))I>0&&n.push({name:u,length:I});if(n.length===0)return t.note("This session knows no sequence lengths, so there is no genome to cut into stretches. Load a chrom.sizes, or the map itself."),[];const A=T(t.params,"resolution",0),s=A>0?Math.round(A):t.framing.binsize>0&&!Oi(t.framing)?t.framing.binsize:Xh;let r=st(t.params,"groupBy","features")==="track"?await tu(t,n,s):jh(t,n,s);if(r===null)return[];if(r=eu(r,t),r.stretches.length===0)return t.note("No stretch of the genome fell in any group, so there is nothing to compare."),[];const o=u=>t.inputs.labels?.[u]??u,i=r.names.length,a=[],c=[],l=[];for(let u=0;u<e.length;u++){t.throwIfCancelled();const I=o(e[u]);t.progress(u,e.length,I);const d=await ws(t,e[u],r.stretches),C=r.names.map(()=>[]);for(let m=0;m<r.stretches.length;m++)Number.isFinite(d[m])&&C[r.stretches[m].group].push(d[m]);if(C.every(m=>m.length===0)){t.note(`${I} has no value over any stretch — its sequence names may not be the assembly's.`);continue}let E=0,B=0;for(const m of C){for(const p of m)B+=p;E+=m.length}for(let m=0;m<i;m++){const p=qh(C[m]),w=E-p.n,y=w>0?(B-p.mean*p.n)/w:Number.NaN;let N=0;for(const k of r.stretches)k.group===m&&(N+=k.end-k.start);a.push({track:I,group:r.names[m],n:p.n,bases:N,mean:p.mean,sd:p.sd,median:p.median,q1:p.q1,q3:p.q3,vsRest:p.n>0?p.mean-y:Number.NaN})}const Q=C.map((m,p)=>({group:m,g:p})).filter(m=>m.group.length>0);if(Q.length>2){const m=Wh(Q.map(p=>p.group));c.push({track:I,test:"Kruskal–Wallis H",a:`all ${Q.length} groups`,b:"",statistic:m.h,effect:Number.NaN,difference:Number.NaN,p:m.p})}for(let m=0;m<Q.length;m++)for(let p=m+1;p<Q.length;p++){const w=Q[m],y=Q[p],N=Hh(w.group,y.group);c.push({track:I,test:"Mann–Whitney U",a:r.names[w.g],b:r.names[y.g],statistic:N.u,effect:N.effect,difference:Te(Ae(w.group),.5)-Te(Ae(y.group),.5),p:N.p})}l.push({kind:"curve",id:`groupsignal-${u+1}`,label:`${I} by ${r.of}`,series:C.map((m,p)=>{const w=ou(m);return{name:r.names[p],x:Float64Array.from(w,(y,N)=>N),y:w,colour:r.colours[p],n:m.length,mark:"violin"}}),xLabel:r.of,yLabel:I,xScale:"linear",yScale:"linear"})}if(t.progress(e.length,e.length,"done"),l.length===0)return[];const g=Kh(c.map(u=>Number(u.p)));c.forEach((u,I)=>{u.q=g[I]});const f=l.some(u=>u.series.some(I=>(I.n??0)>ue));t.note(`Compared over ${r.stretches.length.toLocaleString()} stretches of at most ${s.toLocaleString()} bp in ${i} groups, each the track's mean over the bases it has a value for.${f?` A violin of more than ${ue.toLocaleString()} is drawn from that many, evenly by rank; the tests use every one.`:""}`);const h=[...l];if(h.push({kind:"table",id:"groupsignal-groups",label:`Groups · ${r.of}`,columns:[{key:"track",label:"Track",kind:"text"},{key:"group",label:"Group",kind:"text"},{key:"n",label:"Stretches",kind:"number"},{key:"bases",label:"Bases",kind:"number"},{key:"mean",label:"Mean",kind:"number",digits:4},{key:"sd",label:"SD",kind:"number",digits:4},{key:"median",label:"Median",kind:"number",digits:4},{key:"q1",label:"Q1",kind:"number",digits:4},{key:"q3",label:"Q3",kind:"number",digits:4},{key:"vsRest",label:"Mean − rest",kind:"number",digits:4,hint:"This group’s mean less that of every other stretch."}],rows:a}),h.push({kind:"table",id:"groupsignal-tests",label:"Between groups",columns:[{key:"track",label:"Track",kind:"text"},{key:"test",label:"Test",kind:"text"},{key:"a",label:"Group",kind:"text"},{key:"b",label:"Against",kind:"text"},{key:"difference",label:"Median difference",kind:"number",digits:4},{key:"effect",label:"Effect",kind:"number",digits:3,hint:"Rank-biserial r: +1 where every value of the group is above every value against it."},{key:"statistic",label:"U or H",kind:"number",digits:2},{key:"p",label:"P",kind:"number",digits:4,scientific:!0},{key:"q",label:"q",kind:"number",digits:4,scientific:!0,hint:"Benjamini–Hochberg, over every test of the run."}],rows:c}),r.segments!==void 0&&h.push({kind:"intervals",id:"groupsignal-segments",label:`Groups · ${r.of}`,payload:{kind:"features",data:r.segments},noun:{one:"segment",many:"segments"},display:"lane",look:"corner"}),st(t.params,"groupBy","features")!=="track"&&Lt(t.params,"perFeature",!1)){const u=await ru(t,e,o);u!==null&&h.push(u)}return h};function jh(t,e,n){const A=ne(t.inputs.features,t.params,"features"),s={chosen:A.chosen,value:A.chosen?A.value:void 0},r=s.value;if(r===void 0)return t.note(_n(s,{unchosen:"No feature set was chosen to make the groups from.",gone:"The feature set chosen is no longer loaded. Re-open the file, or pick another."})??""),null;const o=st(t.params,"split","name"),i=t.inputs.labels?.[at(t.params,"features")??""]??"the set",a=new Array(r.length).fill(null);let c;if(o==="score"){const Q=qi(t),m=Yi(r.score,Q);if(m.length===0)return t.note(`${i} carries no scores, so it cannot be cut into quantiles of them.`),null;c=Array.from({length:Q},(p,w)=>Hi(w,m));for(let p=0;p<r.length;p++){const w=Wi(r.score[p],m);w>=0&&(a[p]=c[w])}}else if(o==="strand"){c=["+ strand","− strand","no strand"];for(let Q=0;Q<r.length;Q++)a[Q]=r.strand[Q]>0?c[0]:r.strand[Q]<0?c[1]:c[2]}else if(o==="none")c=[i],a.fill(i);else{for(let Q=0;Q<r.length;Q++)a[Q]=r.name[Q]===""?"(no name)":r.name[Q];c=[...new Set(a.filter(Q=>Q!==null))].sort((Q,m)=>Q.localeCompare(m,void 0,{numeric:!0}))}const l=c.filter(Q=>a.includes(Q)),g=Lt(t.params,"outside",!0),f=g?[...l,kr]:l,h=new Map(f.map((Q,m)=>[Q,m])),u=Q=>e.find(m=>m.name===Q)?.length??t.lengthOf(Q),I=new Map,d=new Set;for(let Q=0;Q<r.contigs.length;Q++){const m=r.contigs[Q],p=u(m);if(p===void 0){r.contigAt[Q+1]>r.contigAt[Q]&&d.add(m);continue}const w=f.map(()=>[]);for(let y=r.contigAt[Q];y<r.contigAt[Q+1];y++){const N=a[y];if(N===null)continue;const k=Math.max(0,r.start[y]),b=Math.min(p,r.end[y]);b>k&&w[h.get(N)??0].push([k,b])}I.set(m,w.map(br))}d.size>0&&t.note(`${[...d].slice(0,6).join(", ")}${d.size>6?", …":""} ${d.size===1?"is":"are"} not a sequence of this assembly, so ${d.size===1?"its":"their"} features were left out.`);const C=[],E=new Map;for(const[Q,m]of I)m.forEach((p,w)=>{for(const[y,N]of p)for(const[k,b]of oA(y,N,n))C.push({contig:Q,start:k,end:b,group:w})}),E.set(Q,br(m.flat()));if(g){const Q=f.length-1;for(const{name:m,length:p}of e){let w=0;for(const[y,N]of E.get(m)??[]){for(const[k,b]of oA(w,y,n))C.push({contig:m,start:k,end:b,group:Q});w=Math.max(w,N)}for(const[y,N]of oA(w,p,n))C.push({contig:m,start:y,end:N,group:Q})}}const B=o==="score"?"score":o==="strand"?"strand":o==="none"?"":"name";return{names:f,colours:f.map((Q,m)=>Q===kr?Vh:Mn[m%Mn.length]),stretches:C,of:B===""?i:`${i}, by ${B}`}}async function tu(t,e,n){const A=at(t.params,"groupTrack");if(A===null)return t.note("No track was chosen to group the bins by."),null;const s=t.inputs.labels?.[A]??A,r=[];for(const h of e)for(let u=0;u<h.length;u+=n)r.push({contig:h.name,start:u,end:Math.min(h.length,u+n),group:-1});const o=await ws(t,A,r),i=st(t.params,"cut","sign")==="quantiles"?"quantiles":"sign";let a;if(i==="sign"){a=["above 0","below 0"];for(let h=0;h<r.length;h++)r[h].group=o[h]>0?0:o[h]<0?1:-1}else{const h=qi(t),u=Yi(o,h);if(u.length===0)return t.note(`${s} has no value over any bin, so there is nothing to cut into quantiles.`),null;a=Array.from({length:h},(I,d)=>Hi(d,u));for(let I=0;I<r.length;I++)r[I].group=Wi(o[I],u)}const c=r.filter(h=>h.group>=0);c.length<r.length&&t.note(`${(r.length-c.length).toLocaleString()} of ${r.length.toLocaleString()} bins had no reading of ${s}${i==="sign"?", or read exactly 0,":""} and are in no group.`);const l=new et;let g=null;const f=()=>{g!==null&&l.add(g.contig,g.start,g.end,{name:a[g.group]}),g=null};for(const h of c){if(g!==null&&g.contig===h.contig&&g.group===h.group&&g.end===h.start){g.end=h.end;continue}f(),g={...h}}return f(),{names:a,colours:a.map((h,u)=>Mn[u%Mn.length]),stretches:c,of:`${s}, ${i==="sign"?"by sign":"in quantiles"}`,segments:l.finish()}}function eu(t,e){const n=new Array(t.names.length).fill(0);for(const o of t.stretches)n[o.group]++;if(n.every(o=>o>0))return t;const A=t.names.filter((o,i)=>n[i]===0);e.note(`${A.join(", ")} had no stretch in ${A.length===1?"it":"them"}, and ${A.length===1?"is":"are"} left out.`);const s=t.names.map((o,i)=>i).filter(o=>n[o]>0),r=new Map(s.map((o,i)=>[o,i]));return{...t,names:s.map(o=>t.names[o]),colours:s.map(o=>t.colours[o]),stretches:t.stretches.map(o=>({...o,group:r.get(o.group)??0}))}}function 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Check that the track and the set share an assembly."),[];I>0&&t.note(`${I.toLocaleString()} features were dropped: shorter than the body width, or with no window left after clipping to the sequence.`);const y=RA(E);C.push({kind:"curve",id:"metaplot",label:"Metaplot",series:d,xLabel:y.label,yLabel:a?"Signal (z-score, per track)":"Mean signal",xScale:"linear",yScale:"linear"});const N=Q.length===0?[]:m.map(yu),k={zscore:a,tracks:e.length};return Q.forEach((b,D)=>{C.push(Nu(b,N[b.group],D,E,y.label,k))}),C},Qu=1<<20,Bu=4096;async function Eu(t,e,n,A){const s=new Float64Array(n.length*A.slots).fill(Number.NaN),r=new Map;for(let o=0;o<n.length;o++){const i=r.get(n[o].contig);i===void 0?r.set(n[o].contig,[o]):i.push(o)}for(const[o,i]of r){const a=new Map;for(const g of i){const f=`${n[g].start}-${n[g].end}`,h=a.get(f);h===void 0?a.set(f,[g]):h.push(g)}const c=[...a.keys()].map(g=>{const[f,h]=g.split("-").map(Number);return{contig:o,start:f,end:h}}).sort((g,f)=>g.start-f.start||g.end-f.end),l=new Map;for(let g=0;g<c.length;){t.throwIfCancelled();let f=g+1,h=c[g].end-c[g].start;for(;f<c.length&&f-g<Bu&&(h+=c[f].end-c[f].start,!(h>Qu));)f++;const u=await t.sample(e,c.slice(g,f),1);g=f;for(const I of u.regions)for(const d of a.get(`${I.start}-${I.end}`)??[]){const C=n[d],{body:E,span:B}=C,Q=`${C.start}-${C.end}:${C.strand}:${C.slotFrom}-${C.slotTo}`+(B===void 0?"":`:${B.start}-${B.end}`)+(E===void 0?"":`:${E.start}-${E.end}:${E.slotFrom}-${E.slotTo}`),m=l.get(Q);if(m!==void 0){s.copyWithin(d*A.slots,m*A.slots,(m+1)*A.slots);continue}l.set(Q,d),s.set(cu(I,C,A.slots),d*A.slots)}}}return s}function mu(t){const e=Math.max(1,Math.floor(t.length/1e5)),n=[];for(let i=0;i<t.length;i+=e){const a=t[i];Number.isFinite(a)&&n.push(a)}if(n.length===0)return null;n.sort((i,a)=>i-a);const A=i=>n[Math.min(n.length-1,Math.floor(i*(n.length-1)))],s=A(.99),r=n[0]>=0?0:-Math.max(Math.abs(A(.01)),Math.abs(s)),o=n[0]>=0?s:Math.max(Math.abs(A(.01)),Math.abs(s));return o>r?[r,o]:null}function wu(t){const{x:e}=RA(t);if(e.length===0)return[];if(t.bodyTo>t.bodyFrom)return["","","","",""];const A=t.flankStep>0?t.flankStep:1,s=e[0]-A/2,r=e[e.length-1]+A/2;return[0,.25,.5,.75,1].map(o=>{const i=s+o*(r-s);return Math.abs(i)>=1e4?`${Number((i/1e3).toFixed(1))} kb`:String(Math.round(i))})}function pu(t,e,n,A){for(let s=0;s<n;s++){let r=0,o=0;for(let i=0;i<A;i++){const a=e[s*A+i];Number.isFinite(a)&&(r+=a,o++)}t.total[s]+=r,t.seen[s]+=o}}function yu(t){const e=t.total.length,n=new Float64Array(e);for(let A=0;A<e;A++)n[A]=t.seen[A]===0?Number.NaN:t.total[A]/t.seen[A];return Array.from({length:e},(A,s)=>s).sort((A,s)=>Number.isNaN(n[A])?Number.isNaN(n[s])?0:1:Number.isNaN(n[s])?-1:n[s]-n[A])}function Nu(t,e,n,A,s,r){const{rows:o,count:i}=t,a=new Float32Array(i*A.slots);for(let l=0;l<i;l++)a.set(o.subarray(e[l]*A.slots,(e[l]+1)*A.slots),l*A.slots);const c=mu(a);return{kind:"matrix",id:n===0?"metaplot-heatmap":`metaplot-heatmap-${n+1}`,label:`${t.name} · per feature${r.zscore?", z-scored":""}`,nrows:i,ncols:A.slots,values:a,xLabel:s,yLabel:r.tracks===1?`Features, strongest first (${i.toLocaleString()})`:`Features, strongest first across ${r.tracks} tracks (${i.toLocaleString()})`,xTicks:wu(A),yTicks:[],colormap:"viridis",...c===null?{}:{range:c},aspect:"fill"}}const Nt=1,kt=2,bt=4,dt=8,ku=Nt|kt|bt|dt,Xi=(()=>{const t=new Uint8Array(256),e={A:Nt,C:kt,G:bt,T:dt,U:dt,R:Nt|bt,Y:kt|dt,S:bt|kt,W:Nt|dt,K:bt|dt,M:Nt|kt,B:kt|bt|dt,D:Nt|bt|dt,H:Nt|kt|dt,V:Nt|kt|bt,N:ku};for(const[n,A]of Object.entries(e))t[n.charCodeAt(0)]=A,t[n.toLowerCase().charCodeAt(0)]=A;return t})(),bu=(()=>{const t=new Uint8Array(16);for(let e=0;e<16;e++){let n=0;(e&Nt)!==0&&(n|=dt),(e&kt)!==0&&(n|=bt),(e&bt)!==0&&(n|=kt),(e&dt)!==0&&(n|=Nt),t[e]=n}return t})();function Ye(t){return!(t instanceof Uint8Array)}const Fr=200;function Oe(t){const e=t.replace(/\s+/g,"");if(e==="")return{reason:"Type a sequence to search for."};if(e.length>Fr)return{reason:`${e.length} bases is longer than this searches for (${Fr}). 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Use A C G T U and the ambiguity codes R Y S W K M B D H V N.`};n[A]=s}return n}function Vi(t){const e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)e[n]=bu[t[t.length-1-n]??0]??0;return e}function Du(t){const e=Vi(t);for(let n=0;n<t.length;n++)if(t[n]!==e[n])return!1;return!0}function Sr(t,e,n,A){let s=0;for(let r=0;r<e.length;r++){const o=Xi[t[n+r]??0]??0,i=e[r]??0;if((o===0||(o&~i)!==0)&&(s++,s>A))return s}return s}function ps(t,e,n={}){const A=[];if(e.length===0||t.length<e.length)return{hits:A,truncated:!1};const s=n.offset??0,r=n.limit??Number.POSITIVE_INFINITY,o=Math.max(0,Math.min(e.length-1,Math.floor(n.mismatches??0))),i=n.bothStrands===!0,a=i&&Du(e),c=i&&!a?Vi(e):null,l=a?0:1,g=t.length-e.length;for(let f=0;f<=g;f++){const h=Sr(t,e,f,o);if(h<=o&&(A.push({start:f+s,end:f+e.length+s,strand:l,mismatches:h}),A.length>=r))return{hits:A,truncated:f<g};if(c!==null){const u=Sr(t,c,f,o);if(u<=o&&(A.push({start:f+s,end:f+e.length+s,strand:-1,mismatches:u}),A.length>=r))return{hits:A,truncated:f<g}}}return{hits:A,truncated:!1}}function Mu(t){return Math.max(0,t.length-1)}function Fu(t){return t>0?"+":t<0?"−":"±"}function Su(t,e){const n=new et,A=e.replace(/\s+/g,"").toUpperCase();for(const s of t.hits)for(let r=0;r<s.starts.length;r++){const o=s.strands[r],i=s.mismatches?.[r];n.add(s.contig,s.starts[r],s.ends[r],{strand:o,name:`${A} ${Fu(o)}`,...i===void 0?{}:{score:i,detail:`${i} ${i===1?"mismatch":"mismatches"}`}})}return n.finish()}function Zi(t,e,n){const A=[];let s=0;for(const i of e){const a=Math.max(1,Math.ceil(i.length/n));A.push({name:i.name,startBin:s,bins:a,length:i.length}),s+=a}const r=new Float32Array(s),o=new Map(A.map(i=>[i.name,i]));for(const i of t.hits){const a=o.get(i.contig);if(a!==void 0)for(let c=0;c<i.starts.length;c++){const l=Math.min(a.bins-1,Math.floor(i.starts[c]/n));r[a.startBin+l]+=1}}return{binsize:n,firstBin:0,values:r,contigs:A}}function Ru(t,e,n=0){const A=t.replace(/\s+/g,"").toUpperCase(),s=[...e?["both strands"]:[],...n>0?[`≤ ${n} ${n===1?"mismatch":"mismatches"}`]:[]];return s.length===0?A:`${A} (${s.join(", ")})`}const un=5e5,Lu=16e6;function xu(t){const e=t.pattern;return typeof e=="string"?e.replace(/\s+/g,"").toUpperCase():""}async function Gu(t,e,n){const A=Math.max(1,Math.min(n.limit,un)),s=n.mismatches??0,r=n.contigs??t.contigs,o=Mu(e),i=t.read?.bind(t),a=Math.max(1,Math.floor(n.piece??Lu)),c=[];let l=0,g=!1;const f=r.reduce((u,I)=>u+I.length,0);let h=0;for(const u of r){if(l>=A){g=!0;break}const I=[];let d=!1;const C=(w,y)=>{const N=A-l-I.length,k=ps(w,e,{bothStrands:n.bothStrands,limit:N+1,mismatches:s,offset:y});for(let b=0;b<Math.min(k.hits.length,N);b++)I.push(k.hits[b]);(k.truncated||k.hits.length>N)&&(d=!0)};if(i===void 0){const w=t.bases(u.name);if(w===void 0)continue;C(w,0),h+=u.length,n.progress?.(h,f,u.name)}else for(let w=0;w<u.length&&!d;w+=a){n.throwIfCancelled?.();const y=Math.min(u.length,w+a),N=await i(u.name,w,Math.min(u.length,y+o));if(N===void 0)break;C(N,w),h+=y-w,n.progress?.(h,f,u.name)}d&&(g=!0);const E=I.length;if(E===0){if(d)break;continue}const B=new Int32Array(E),Q=new Int32Array(E),m=new Int8Array(E),p=s>0?new Uint8Array(E):void 0;for(let w=0;w<E;w++){const y=I[w];B[w]=y.start,Q[w]=y.end,m[w]=y.strand,p!==void 0&&(p[w]=y.mismatches)}if(c.push({contig:u.name,starts:B,ends:Q,strands:m,...p===void 0?{}:{mismatches:p}}),l+=E,d)break}return{hits:c,total:l,truncated:g}}function ji(t,e,n){if(e===null)return[...t.contigs];const A=new Set(e);if(n.length>0&&n.every(r=>A.has(r)))return[...t.contigs];const s=new Set;for(const r of e){const o=Kt(t.contigs,r);o>=0&&s.add(o)}return t.contigs.filter((r,o)=>s.has(o))}const Uu=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to search."),[];if(e===null)return t.note("No reference was chosen. Load a FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.read===void 0&&n.refusal!==void 0)return t.note(n.refusal),[];const A=On(t.params,"sequences");if(A!==null&&A.length===0)return t.note("No sequence is ticked, so there is nothing to search."),[];const s=Object.entries(t.inputs.contigLengths??{}).filter(([,E])=>E>0).map(([E])=>E),r=ji(n,A,s);if(r.length===0)return t.note("None of the ticked sequences is in this reference, so there is nothing to search."),[];const o=r.length===n.contigs.length,i=xu(t.params),a=Oe(i);if(Ye(a))return t.note(a.reason),[];const c=Lt(t.params,"bothStrands",!0),l=Math.min(un,Math.max(1,Math.round(T(t.params,"limit",un)))),g=Math.max(0,Math.min(a.length-1,Math.round(T(t.params,"mismatches",0))));t.progress(0,1,r.length===1?`searching ${r[0].name}`:`searching ${r.length.toLocaleString()} sequences`);const f=await Gu(n,a,{bothStrands:c,limit:l,mismatches:g,contigs:r,...n.read===void 0?{}:{progress:(E,B,Q)=>t.progress(E,B,`searching ${Q}`),throwIfCancelled:()=>t.throwIfCancelled()}});t.progress(1,1,"done");const h=vu(Ru(i,c,g),r,o);if(f.total===0)return t.note(o?`No match for ${h} anywhere in this reference.`:`No match for ${h}.`),[];const u=`${f.total.toLocaleString()} site${f.total===1?"":"s"}`;t.note(f.truncated?`${u} — the search stopped at the limit of ${l.toLocaleString()} and there are more. `+(l<un?"Raise “Most sites”, or narrow the pattern.":r.length>1?"That is the most one run reports, so narrow the pattern or tick fewer sequences.":"That is the most one run reports, so narrow the pattern."):`${u}, on ${f.hits.length.toLocaleString()} ${f.hits.length===1?"sequence":"sequences"}.`);const I=`motif-${i}${c?"-both":""}${g>0?`-mm${g}`:""}`+(o?"":Tu(r)),d=[Ju(f,i,h,I)],C=$u(t,f,h,I);return C!==null&&d.push(C),d};function vu(t,e,n){return n?t:e.length<=3?`${t} on ${e.map(A=>A.name).join(", ")}`:`${t} on ${e.length.toLocaleString()} sequences`}function Tu(t){const e=t.map(A=>A.name);if(e.length<=3)return`-on-${e.map(A=>A.replace(/[^A-Za-z0-9]/g,"")).join("-")}`;let n=5381;for(const A of e.join(`
-`))n=(n*33^A.charCodeAt(0))>>>0;return`-on${e.length}-${n.toString(36)}`}function Ju(t,e,n,A){return{kind:"intervals",id:A,label:n,payload:{kind:"features",data:Su(t,e)},noun:{one:"site",many:"sites"},display:"lane",look:"point"}}function $u(t,e,n,A){const s=t.framing.binsize,r=Kn(t);if(!(s>0)||r.length===0)return t.note("The sites are a lane; the density is not. A per-bin track needs the bin grid of an open contact map, and this session has none — so there is nothing for a density to be per. Open the map and run it again for that half."),null;const o=Zi(e,r,s);return{kind:"profile",id:`${A}-density`,label:`${n} density`,values:o.values,extent:[0,o.values.length],binsize:s,unit:"sites"}}function Kn(t){const e=t.inputs.contigLengths;if(e===void 0)return[];const n=[];for(const[A,s]of Object.entries(e))s>0&&n.push({name:A,length:s});return n}let ce=null,An=null;function Yu(){if(ce===null||An===null){ce=new Uint32Array(256);for(let t=0;t<256;t++){const e=Ne[t];ce[t]=e<4?1<<8*e:0}An=new Uint32Array(65536);for(let t=0;t<65536;t++)An[t]=ce[t&255]+ce[t>>>8]}return[ce,An]}const Ou=63;function ys(t,e){const n=Math.max(1,Math.round(e)),A=t.length===0?0:Math.ceil(t.length/n),s=new Int32Array(A),r=new Int32Array(A),o=new Int32Array(A),i=new Int32Array(A),[a,c]=Yu(),l=4-(t.byteOffset&3)&3,g=new Uint32Array(t.buffer,t.byteOffset+l,Math.max(0,t.length-l>>2));for(let f=0;f<A;f++){const h=f*n,u=Math.min(t.length,h+n),I=Math.min(u,h<=l?l:l+(h-l+3>>2<<2)),d=u-I>>2;let C=0;for(let y=h;y<I;y++)C+=a[t[y]];for(let y=I+4*d;y<u;y++)C+=a[t[y]];let E=C&255,B=C>>>8&255,Q=C>>>16&255,m=C>>>24,p=I-l>>2;const w=p+d;for(;p<w;){const y=Math.min(w,p+Ou);let N=0;for(;p<y;p++){const k=g[p];N+=c[k&65535]+c[k>>>16]}E+=N&255,B+=N>>>8&255,Q+=N>>>16&255,m+=N>>>24}s[f]=E,r[f]=B,o[f]=Q,i[f]=m}return{step:n,steps:A,a:s,c:r,g:o,t:i}}const ta=1<<22;function _u(t,e=ta){const n=Math.max(1,Math.round(t));return n*Math.max(1,Math.floor(e/n))}async function Ku(t,e,n=ta){const A=Math.max(1,Math.round(e)),s=_u(A,n),r=[];let o=0;for(let l=0;;l+=s){const g=await t(l,l+s);if(g===void 0)return;if(r.push(ys(g,A)),o+=g.length,g.length<s)break}const i=r.reduce((l,g)=>l+g.steps,0),a={step:A,steps:i,a:new Int32Array(i),c:new Int32Array(i),g:new Int32Array(i),t:new Int32Array(i)};let c=0;for(const l of r)a.a.set(l.a,c),a.c.set(l.c,c),a.g.set(l.g,c),a.t.set(l.t,c),c+=l.steps;return{counts:a,length:o}}function ea(t,e,n){const A=Math.max(0,Math.floor(Math.max(1,Math.round(e))/2)),s=t.steps;if(A===0||s===0)return t;const r=o=>{const i=new Int32Array(s),a=new Float64Array(s+1);for(let g=0;g<s;g++)a[g+1]=a[g]+o[g];const c=a[s],l=g=>{if(!n)return a[Math.max(0,Math.min(s,g))];const f=Math.floor(g/s);return f*c+a[g-f*s]};for(let g=0;g<s;g++){const f=n?g-Math.min(A,Math.floor((s-1)/2)):g-A,h=n?g+Math.min(A,Math.floor((s-1)/2))+1:g+A+1;i[g]=l(h)-l(f)}return i};return{...t,a:r(t.a),c:r(t.c),g:r(t.g),t:r(t.t)}}function qu(t){const e=new Float32Array(t.steps);for(let n=0;n<t.steps;n++){const A=t.g[n]+t.c[n],s=A+t.a[n]+t.t[n];e[n]=s>0?A/s:Number.NaN}return e}function LA(t){const e=new Float32Array(t.steps);for(let n=0;n<t.steps;n++){const A=t.g[n]+t.c[n];e[n]=A>0?(t.g[n]-t.c[n])/A:Number.NaN}return e}function Hu(t){const e=new Float32Array(t.steps);for(let n=0;n<t.steps;n++){const A=t.a[n]+t.t[n];e[n]=A>0?(t.a[n]-t.t[n])/A:Number.NaN}return e}function na(t){const e=new Float32Array(t.length);let n=0;for(let A=0;A<t.length;A++){const s=t[A];Number.isFinite(s)&&(n+=s),e[A]=n}return e}const Wu=1e4;function Pu(t){return["gc","gcSkew","atSkew","cumulative"].filter(e=>t[e]!==!1)}function zu(t){return Oi(t.framing)}const Rr={gc:{name:"GC content",unit:""},gcSkew:{name:"GC skew",unit:""},atSkew:{name:"AT skew",unit:""},cumulative:{name:"Cumulative GC skew",unit:""}},Xu=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to read."),[];if(e===null)return t.note("No reference was chosen. Load a FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.read===void 0&&n.refusal!==void 0)return t.note(n.refusal),[];const A=Pu(t.params);if(A.length===0)return t.note("No track was ticked, so there is nothing to make."),[];const s=T(t.params,"resolution",0),r=s>0?Math.round(s):t.framing.binsize>0&&!zu(t)?t.framing.binsize:Wu,o=Kn(t);if(o.length===0)return t.note("There are no sequences to lay the bins out on. Open a map, or load the FASTA itself."),[];const i=Math.max(0,Math.round(T(t.params,"window",0))),a=Math.max(1,Math.round(i/r)),c=a%2===1?a:a+1,l=new Set(t.framing.circular??[]),g=o.reduce((Q,m)=>Q+Math.max(1,Math.ceil(m.length/r)),0),f={gc:new Float32Array(g).fill(Number.NaN),gcSkew:new Float32Array(g).fill(Number.NaN),atSkew:new Float32Array(g).fill(Number.NaN),cumulative:new Float32Array(g).fill(Number.NaN)},{read:h}=n,u=[],I=[];let d=0;for(let Q=0;Q<o.length;Q++){const m=o[Q],p=Math.max(1,Math.ceil(m.length/r));t.progress(Q,o.length,m.name);let w;if(h!==void 0)w=await Ku((D,F)=>(t.throwIfCancelled(),h(m.name,D,F)),r);else{const D=n.bases(m.name);w=D===void 0?void 0:{counts:ys(D,r),length:D.length}}if(w===void 0){u.push(m.name),d+=p;continue}w.length!==m.length&&I.push(m.name);const{counts:y}=w,N=c>1?ea(y,c,l.has(m.name)):y,k={gc:qu(N),gcSkew:LA(N),atSkew:Hu(N),cumulative:na(LA(y))},b=Math.min(p,y.steps);for(const D of A)f[D].set(k[D].subarray(0,b),d);d+=p}if(t.progress(o.length,o.length,"done"),u.length===o.length)return t.note("The reference has none of the map’s sequences under any name this viewer knows, so nothing could be measured."),[];u.length>0&&t.note(`${u.length.toLocaleString()} of the map’s sequences are not in this reference and are gaps on every track: ${u.slice(0,6).join(", ")}${u.length>6?", …":""}.`),I.length>0&&t.note(`${I.slice(0,6).join(", ")}${I.length>6?", …":""} ${I.length===1?"is":"are"} not the length the map says — the reference may be another assembly version. Bins were read from its start.`),c>1&&t.note(`Each bin was read over ${c} bins (${(c*r).toLocaleString()} bp) centred on it; the cumulative skew sums each bin’s own.`);const C=t.inputs.labels?.[e]??"reference",E=c>1?` · ${(c*r).toLocaleString()} bp window`:"";return A.map(Q=>({kind:"profile",id:`composition-${Q.toLowerCase()}`,label:`${Rr[Q].name} · ${C}${Q==="cumulative"?"":E}`,values:f[Q],extent:[0,g],binsize:r,unit:Rr[Q].unit}))},_e=19,Aa=50,Vu=2e6,Zu=5e3,ju=500,tI=10;function Lr(t){const e=[0];for(const n of t)e.push(e[e.length-1]+n.length);return{names:t.map(n=>n.name),lengths:t.map(n=>n.length),offsets:e}}function eI(t,e=Vu){return Math.max(1,Math.ceil(2*t/e-1))}const nI=(()=>{const t=new Int8Array(256).fill(-1);for(const[e,n]of[["A",0],["C",1],["G",2],["T",3]])t[e.charCodeAt(0)]=n,t[e.toLowerCase().charCodeAt(0)]=n;return t})();function AI(t){const e=t>>>0,n=Math.floor(t/4294967296)>>>0;let A=Math.imul(e^Math.imul(n,2654435761),2246822507);return A^=A>>>13,A=Math.imul(A,3266489909),A^=A>>>16,A>>>0}class sI{hash=new Uint32Array(1024);position=new Uint32Array(1024);strand=new Int8Array(1024);count=0;push(e,n,A){if(this.count===this.hash.length){const s=this.hash.length*2,r=new Uint32Array(s);r.set(this.hash),this.hash=r;const o=new Uint32Array(s);o.set(this.position),this.position=o;const i=new Int8Array(s);i.set(this.strand),this.strand=i}this.hash[this.count]=e,this.position[this.count]=n,this.strand[this.count]=A,this.count++}finish(){return{hash:this.hash.slice(0,this.count),position:this.position.slice(0,this.count),strand:this.strand.slice(0,this.count),count:this.count}}}function xr(t,e,n,A=_e){const s=new sI,r=4**(A-1),o=new Float64Array(n+1),i=new Float64Array(n+1),a=new Int8Array(n+1);for(let c=0;c<t.names.length;c++){const l=e(t.names[c]);if(l===void 0)continue;const g=t.offsets[c];let f=0,h=0,u=0,I=0,d=0,C=-1,E=0;const B=o.length;for(let Q=0;Q<l.length;Q++){const m=nI[l[Q]];if(m<0){u=0,d=0,E=0;continue}if(f=f%r*4+m,h=Math.floor(h/4)+(3-m)*r,u++,u<A)continue;const p=Q-A+1;if(E++,f===h)continue;const w=f<h?1:-1,y=AI(f<h?f:h);for(;d>0&&o[(I+d-1)%B]>=y;)d--;for(o[(I+d)%B]=y,i[(I+d)%B]=p,a[(I+d)%B]=w,d++;d>0&&i[I]<=p-n;)I=(I+1)%B,d--;if(E<n)continue;const N=i[I];N!==C&&(s.push(o[I],g+N,a[I]),C=N)}}return s.finish()}function Fn(t,e=t.length,n){let A=new Uint32Array(e);if(n===void 0)for(let o=0;o<e;o++)A[o]=o;else A.set(n.subarray(0,e));let s=new Uint32Array(e);const r=new Uint32Array(65537);for(const o of[0,16]){r.fill(0);for(let i=0;i<e;i++)r[(t[A[i]]>>>o&65535)+1]++;for(let i=0;i<65536;i++)r[i+1]+=r[i];for(let i=0;i<e;i++)s[r[t[A[i]]>>>o&65535]++]=A[i];[A,s]=[s,A]}return A}function rI(t,e,n=Aa){const A=Fn(t.hash,t.count),s=Fn(e.hash,e.count);let r=new Uint32Array(1024),o=new Uint32Array(1024),i=new Int8Array(1024),a=0,c=0,l=0,g=0;for(;l<t.count&&g<e.count;){const f=t.hash[A[l]],h=e.hash[s[g]];if(f<h){l++;continue}if(h<f){g++;continue}let u=l;for(;u<t.count&&t.hash[A[u]]===f;)u++;let I=g;for(;I<e.count&&e.hash[s[I]]===h;)I++;if(u-l>n||I-g>n)c++;else for(let d=l;d<u;d++)for(let C=g;C<I;C++){if(a===r.length){const E=r.length*2,B=new Uint32Array(E);B.set(r),r=B;const Q=new Uint32Array(E);Q.set(o),o=Q;const m=new Int8Array(E);m.set(i),i=m}r[a]=t.position[A[d]],o[a]=e.position[s[C]],i[a]=t.strand[A[d]]===e.strand[s[C]]?1:-1,a++}l=u,g=I}return{x:r.slice(0,a),y:o.slice(0,a),strand:i.slice(0,a),count:a,dropped:c}}function oI(t,e=Zu,n=ju,A=tI,s){const r=[];s?.fill(-1);let o=0;for(let a=0;a<t.count;a++)t.y[a]>o&&(o=t.y[a]);for(const a of[1,-1]){let c=0;for(let B=0;B<t.count;B++)t.strand[B]===a&&c++;const l=new Uint32Array(c),g=new Uint32Array(c),f=new Uint32Array(c),h=Math.ceil(o/n)+1;for(let B=0,Q=0;B<t.count;B++)t.strand[B]===a&&(l[Q]=B,g[Q]=t.x[B],f[Q]=a===1?Math.round((t.x[B]-t.y[B])/n)+h:Math.round((t.x[B]+t.y[B])/n),Q++);const u=Fn(f,c,Fn(g,c)),I=new Uint32Array(c),d=new Uint32Array(c);for(let B=0;B<c;B++)I[B]=l[u[B]],d[B]=f[u[B]];let C=0;const E=B=>{const Q=B-C;if(Q>=A){let m=Number.POSITIVE_INFINITY,p=Number.NEGATIVE_INFINITY,w=Number.POSITIVE_INFINITY,y=Number.NEGATIVE_INFINITY;for(let N=C;N<B;N++){const k=I[N];m=Math.min(m,t.x[k]),p=Math.max(p,t.x[k]+_e),w=Math.min(w,t.y[k]),y=Math.max(y,t.y[k]+_e)}if(s!==void 0)for(let N=C;N<B;N++)s[I[N]]=r.length;r.push({x0:m,x1:p,y0:w,y1:y,strand:a,anchors:Q})}C=B};for(let B=1;B<=I.length;B++){if(B===I.length){E(B);break}const Q=I[B-1],m=I[B];(d[B-1]!==d[B]||t.x[m]-t.x[Q]>e)&&E(B)}}const i=r.map((a,c)=>c).sort((a,c)=>r[a].x0-r[c].x0||r[a].y0-r[c].y0);if(s!==void 0){const a=new Int32Array(r.length);i.forEach((c,l)=>a[c]=l);for(let c=0;c<t.count;c++)s[c]>=0&&(s[c]=a[s[c]])}return i.map(a=>r[a])}const iI=100,aI=4e5;function cI(t,e,n){const A=e.offsets[e.offsets.length-1],s=n.offsets[n.offsets.length-1],r=Math.max(iI,Math.ceil(Math.max(A,s)/aI)),o=new Uint8Array(Math.ceil(A/r)+1),i=new Uint8Array(Math.ceil(s/r)+1),a=(h,u)=>{const I=Math.floor(h/r);return[I,Math.max(I+1,Math.ceil(u/r))]},c=(h,u,I)=>{const[d,C]=a(u,I);let E=0;for(let B=d;B<C;B++)E+=h[B];return E/(C-d)},l=(h,u,I)=>{const[d,C]=a(u,I);h.fill(1,d,C)},g=new Uint8Array(t.length),f=t.map((h,u)=>u).sort((h,u)=>t[u].anchors-t[h].anchors||h-u);for(const h of f){const u=t[h];c(o,u.x0,u.x1)>.5||c(i,u.y0,u.y1)>.5||(g[h]=1,l(o,u.x0,u.x1),l(i,u.y0,u.y1))}return g}function lI(t,e,n,A,s){const r=e.offsets[e.offsets.length-1],o=n.offsets[n.offsets.length-1],i=Math.max(1,Math.ceil(Math.max(r,o)/Math.max(1,A))),a=Math.max(1,Math.ceil(r/i)),c=Math.max(1,Math.ceil(o/i)),l=new Float32Array(a*c);for(let g=0;g<t.count;g++){if(s!==void 0&&s[g]!==1)continue;const f=Math.min(a-1,Math.floor(t.x[g]/i)),h=Math.min(c-1,Math.floor(t.y[g]/i));l[h*a+f]+=t.strand[g]}return{values:l,ncols:a,nrows:c,cellSize:i}}function Gr(t,e){let n=0,A=t.names.length-1;for(;n<A;){const s=n+A+1>>1;t.offsets[s]<=e?n=s:A=s-1}return{sequence:n,at:e-t.offsets[n]}}const Ur=400;function gI(t,e,n,A,s){const r=t.length,o={x:{label:A,names:[...e.names],lengths:[...e.lengths]},y:{label:s,names:[...n.names],lengths:[...n.lengths]},x0:new Float64Array(r),x1:new Float64Array(r),y0:new Float64Array(r),y1:new Float64Array(r),strand:new Int8Array(r),anchors:new Int32Array(r)};return t.forEach((i,a)=>{o.x0[a]=i.x0,o.x1[a]=i.x1,o.y0[a]=i.y0,o.y1[a]=i.y1,o.strand[a]=i.strand,o.anchors[a]=i.anchors}),o}function vr(t,e){return t.names.map((n,A)=>({label:n,from:t.offsets[A]/e,to:t.offsets[A+1]/e}))}const fI=async t=>{const e=at(t.params,"x"),n=at(t.params,"y");if(t.residues===void 0)return t.note("This session cannot read residues, so there is nothing to set against anything."),[];if(e===null||n===null)return t.note("Choose the two sequence sets: one along x, one along y."),[];const A=t.residues(e),s=t.residues(n);if(A===void 0||s===void 0)return t.note("A sequence set chosen is no longer loaded. Drop the FASTA again, or pick another."),[];for(const R of[A,s])if(R.refusal!==void 0)return t.note(R.refusal),[];const r=Lr(A.contigs),o=Lr(s.contigs),i=r.offsets[r.offsets.length-1],a=eI(i);t.progress(0,4,"minimizers along x");const c=xr(r,R=>A.bases(R),a);t.throwIfCancelled(),t.progress(1,4,"minimizers along y");const l=xr(o,R=>s.bases(R),a);t.throwIfCancelled(),t.progress(2,4,"anchors");const g=rI(c,l);t.throwIfCancelled(),t.progress(3,4,"streaks");const f=new Int32Array(g.count),h=oI(g,void 0,void 0,void 0,f),u=e===n,I=!u&&st(t.params,"streaks","one to one")==="one to one",d=I?cI(h,r,o):new Uint8Array(h.length).fill(1),C=h.filter((R,v)=>d[v]===1),E=new Uint8Array(g.count);for(let R=0;R<g.count;R++)f[R]>=0&&d[f[R]]===1&&(E[R]=1);const B=Math.round(T(t.params,"cells",Ur)),Q=lI(g,r,o,B>0?B:Ur,E);t.progress(4,4);const m=c.count>0?Math.round(i/c.count):0,p=h.length-C.length;t.note(`Exact ${_e}-mers, one in about ${m.toLocaleString("en-US")} bases; hashes above ${Aa} copies on either side dropped (${g.dropped.toLocaleString("en-US")} of them). ${g.count.toLocaleString("en-US")} anchors, ${h.length.toLocaleString("en-US")} streaks`+(I?`, ${C.length.toLocaleString("en-US")} of them one to one — ${p.toLocaleString("en-US")} a stronger streak had taken the stretch of`:"")+(u?", every one drawn, the set against itself":"")+`. Not an alignment, and it writes none: a streak is ten or more shared ${_e}-mers along one diagonal.`);const w=[];for(const R of Q.values)Math.abs(R)>=3&&w.push(Math.abs(R));w.sort((R,v)=>R-v);const y=w.length===0?3:Math.max(3,w[Math.floor(.5*(w.length-1))]),N={kind:"matrix",id:"dotplot-density",label:I?"Streaks one to one, the same way round (red) and the other (blue)":"Streaks, the same way round (red) and the other (blue)",nrows:Q.nrows,ncols:Q.ncols,values:Q.values,xLabel:"along x",yLabel:"along y",xTicks:[],yTicks:[],colormap:"RdBu_r",centre:0,range:[-y,y],xSegments:vr(r,Q.cellSize),ySegments:vr(o,Q.cellSize),stats:[{label:"anchors",value:g.count},{label:I?"streaks one to one":"streaks",value:C.length},{label:"bases a cell",value:Q.cellSize}],large:!0,streaks:gI(C,r,o,t.inputs.labels?.[e]??"along x",t.inputs.labels?.[n]??"along y")},k=C.map(R=>{const v=Gr(r,R.x0),x=Gr(o,R.y0);return{xSequence:r.names[v.sequence],xStart:v.at,xEnd:v.at+(R.x1-R.x0),ySequence:o.names[x.sequence],yStart:x.at,yEnd:x.at+(R.y1-R.y0),strand:R.strand===1?"+":"-",anchors:R.anchors}}),b={kind:"table",id:"dotplot-streaks",label:"Streaks",columns:[{key:"xSequence",label:"x sequence",kind:"text"},{key:"xStart",label:"x start",kind:"number",coordinate:"start"},{key:"xEnd",label:"x end",kind:"number",coordinate:"end"},{key:"ySequence",label:"y sequence",kind:"text"},{key:"yStart",label:"y start",kind:"number",coordinate:"start"},{key:"yEnd",label:"y end",kind:"number",coordinate:"end"},{key:"strand",label:"strand",kind:"text",hint:"+ the same way round, − the other"},{key:"anchors",label:"anchors",kind:"number"}],rows:k},D=new Jn;for(const R of k)D.add(R.xSequence,R.xStart,R.xEnd,R.ySequence,R.yStart,R.yEnd,{score:R.anchors,name:R.strand==="+"?"same way round":"the other way round",detail:`${R.anchors} anchors`});const F={kind:"intervals",id:"dotplot-pairs",label:"Streaks, as pairs",payload:{kind:"pairs",data:D.finish()},noun:{one:"streak",many:"streaks"},display:"overlay"};return[N,b,F]};function xA(t,e,n,A){const s=Math.abs(t-e);return A&&n>0?Math.min(s,n-s%n):s}function hI(t,e,n){if(t.length===0)return Number.NaN;if(!n||!(e>0)){let i=0;for(const a of t)i+=a;return i/t.length}let A=0,s=0;for(const i of t){const a=2*Math.PI*i/e;A+=Math.sin(a),s+=Math.cos(a)}const o=(Math.atan2(A,s)/(2*Math.PI)*e%e+e)%e;return o>=e?0:o}function Tr(t,e,n,A){if(t.length===0)return null;let s=-1,r=0;for(let i=0;i<t.length;i++){let a=0;for(const c of t)xA(t[i],c,e,n)<=A&&a++;a>r&&(r=a,s=i)}const o=t.filter(i=>xA(t[s],i,e,n)<=A);return{centre:hI(o,e,n),count:o.length}}function uI(t,e,n){let A=-1,s=-1;for(let o=0;o<t.length;o++){const i=t[o];Number.isFinite(i)&&((A<0||i<t[A])&&(A=o),(s<0||i>t[s])&&(s=o))}const r=o=>o<0?Number.NaN:Math.min(n-1,Math.floor(o*e+e/2));return{low:r(A),high:r(s)}}const II=10;function dI(t){const{length:e,circular:n,low:A,high:s}=t,r=e/8,o=Tr(t.matS,e,n,r),i=Tr(t.parS,e,n,r),a=t.minMatS??II,c=(h,u)=>xA(h,u,e,n);let l=s,g="skew";if(o!==null&&t.matS.length>=a)l=c(A,o.centre)<c(s,o.centre)?A:s,g="matS";else if(i!==null)l=c(A,i.centre)>c(s,i.centre)?A:s,g="parS";else if(t.coverageAt!==void 0){const h=t.coverageAt(A),u=t.coverageAt(s);Number.isFinite(h)&&Number.isFinite(u)&&h!==u&&(l=h<u?A:s,g="coverage")}return{ori:l===s?A:s,ter:l,rule:g,agreesWithSkew:l===s,matS:o,parS:i}}function CI(t,e,n,A,s){const r=Math.max(s?3:1,Math.round(A)),o=s?r:r+3,i=n>0?r/n:0,a=B=>{let Q=B*i;s||(Q=Math.max(0,Math.min(r-1e-9,Q)));const m=Math.floor(Q),p=Q-m,w=[(1-p)**3/6,(3*p**3-6*p**2+4)/6,(-3*p**3+3*p**2+3*p+1)/6,p**3/6];return{first:s?m-1:m,w}},c=B=>s?(B%o+o)%o:B,l=new Float64Array(o*o),g=new Float64Array(o);let f=0;for(let B=0;B<t.length;B++){const Q=e[B];if(!Number.isFinite(Q))continue;f++;const{first:m,w:p}=a(t[B]);for(let w=0;w<4;w++){const y=c(m+w);g[y]+=p[w]*Q;for(let N=0;N<4;N++)l[y*o+c(m+N)]+=p[w]*p[N]}}let h=0,u=0;for(let B=0;B<e.length;B++)Number.isFinite(e[B])&&(h+=e[B],u++);h=u>0?h/u:0;const I=1e-6*Math.max(1,f/o);for(let B=0;B<o;B++)l[B*o+B]+=I,g[B]+=I*h;const d=QI(l,g,o),C=B=>{if(d===null)return Number.NaN;const{first:Q,w:m}=a(B);let p=0;for(let w=0;w<4;w++)p+=m[w]*d[c(Q+w)];return p},E=new Float64Array(t.length);for(let B=0;B<t.length;B++)E[B]=C(t[B]);return{fitted:E,at:C}}function QI(t,e,n){const A=Float64Array.from(t),s=Float64Array.from(e);for(let o=0;o<n;o++){let i=o;for(let a=o+1;a<n;a++)Math.abs(A[a*n+o])>Math.abs(A[i*n+o])&&(i=a);if(Math.abs(A[i*n+o])<1e-300)return null;if(i!==o){for(let c=0;c<n;c++){const l=A[o*n+c];A[o*n+c]=A[i*n+c],A[i*n+c]=l}const a=s[o];s[o]=s[i],s[i]=a}for(let a=o+1;a<n;a++){const c=A[a*n+o]/A[o*n+o];if(c!==0){for(let l=o;l<n;l++)A[a*n+l]-=c*A[o*n+l];s[a]-=c*s[o]}}}const r=new Float64Array(n);for(let o=n-1;o>=0;o--){let i=s[o];for(let a=o+1;a<n;a++)i-=A[o*n+a]*r[a];r[o]=i/A[o*n+o]}return r}function BI(t){let e=Number.NEGATIVE_INFINITY,n=Number.POSITIVE_INFINITY;for(const s of t)Number.isFinite(s)&&(s>e&&(e=s),s<n&&(n=s));return{ratio:n>0&&Number.isFinite(e)?e/n:Number.NaN,highest:e,lowest:n}}const EI="TGTTNCACGTGNAACA",mI="GTGACRNYGTCAC";function wI(t,e){const n=t[e];return n==null?e==="parS"?EI:mI:typeof n=="string"?n.replace(/\s+/g,"").toUpperCase():""}const pI=5e3,aA={matS:"nearest the matS cluster",parS:"farthest from the parS cluster",coverage:"lower coverage",skew:"skew maximum"};function Jr(t,e,n){const A={mids:[],starts:[],ends:[],strands:[],mismatches:[]};if(e===null)return A;for(const s of ps(t,e,{bothStrands:!0,mismatches:n}).hits)A.mids.push((s.start+s.end)/2),A.starts.push(s.start),A.ends.push(s.end),A.strands.push(s.strand),A.mismatches.push(s.mismatches);return A}const yI=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to read."),[];if(e===null)return t.note("No reference was chosen. Load the genome’s FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.refusal!==void 0)return t.note(n.refusal),[];const A={parS:{motif:null,pattern:"",mismatches:0},matS:{motif:null,pattern:"",mismatches:0}};for(const N of["parS","matS"]){const k=wI(t.params,N);if(k==="")continue;const b=Oe(k);if(Ye(b)){t.note(`${N}: ${b.reason} Its step was skipped.`);continue}const D=Math.round(T(t.params,`${N}Mismatches`,N==="parS"?1:0));A[N]={motif:b,pattern:k,mismatches:Math.max(0,Math.min(b.length-1,D))}}const s=Math.max(100,Math.round(T(t.params,"window",5e3))),r=Math.max(10,Math.min(s,Math.round(T(t.params,"step",1e3)))),o=Math.max(4,Math.min(40,Math.round(T(t.params,"knots",10)))),i=at(t.params,"coverage"),a=new Set(t.framing.circular??[]),c=Kn(t),l=c.length>0?c.map(N=>N.name):n.contigs.map(N=>N.name),g=On(t.params,"sequences"),f=g===null?l:l.filter(N=>g.includes(N));if(f.length===0)return t.note("No sequence is ticked, so there is nothing to read."),[];const h=new et,u=new et,I=new et;let d=0,C=0;const E=[],B=new Map,Q=[];for(let N=0;N<f.length;N++){const k=f[N];t.progress(N,f.length,k);const b=n.bases(k);if(b===void 0){Q.push(k);continue}const D=b.length;if(D<4*s){Q.push(k);continue}const F=a.has(k),R=ys(b,r),v=LA(ea(R,Math.max(1,Math.round(s/r)),F)),x=uI(na(v),r,D);if(!Number.isFinite(x.low)||!Number.isFinite(x.high)){Q.push(k);continue}const Y=Jr(b,A.parS.motif,A.parS.mismatches),J=Jr(b,A.matS.motif,A.matS.mismatches);let K,V=Number.NaN;if(i!==null){const L=(await t.sample(i,[{contig:k,start:0,end:D}],pI)).regions[0];if(L!==void 0&&L.values.length>3){const $=new Float64Array(L.values.length),Dt=new Float64Array(L.values.length);for(let P=0;P<L.values.length;P++)$[P]=(L.starts[P]+L.ends[P])/2,Dt[P]=L.values[P];const Ut=CI($,Dt,D,o,F);K=Ut.at,B.set(k,Ut.at),V=BI(Ut.fitted).ratio}}const H=dI({length:D,circular:F,low:x.low,high:x.high,parS:Y.mids,matS:J.mids,...K===void 0?{}:{coverageAt:K}}),ht=Math.floor(s/2),Gt=`${aA[H.rule]}${H.agreesWithSkew?"":" · disagrees with the skew"}`;for(const[q,L]of[["ori",H.ori],["ter",H.ter]])h.add(k,Math.max(0,L-ht),Math.min(D,L+ht),{name:q,detail:q==="ter"?`terminus · ${Gt}`:"origin"});for(let q=0;q<Y.starts.length;q++)u.add(k,Y.starts[q],Y.ends[q],{strand:Y.strands[q],name:"parS",score:Y.mismatches[q],detail:`${Y.mismatches[q]} ${Y.mismatches[q]===1?"mismatch":"mismatches"}`});for(let q=0;q<J.starts.length;q++)I.add(k,J.starts[q],J.ends[q],{strand:J.strands[q],name:"matS",score:J.mismatches[q],detail:`${J.mismatches[q]} ${J.mismatches[q]===1?"mismatch":"mismatches"}`});d+=Y.starts.length,C+=J.starts.length,H.agreesWithSkew||t.note(`${k}: the terminus was placed ${aA[H.rule]}, at the cumulative skew’s minimum — which is where the skew alone would put the origin. Check the assembly, or the motifs.`),E.push({sequence:k,length:D,topology:F?"circular":"linear",ori:H.ori+1,ter:H.ter+1,rule:aA[H.rule],parS:Y.starts.length,parSCluster:H.parS?.count??0,matS:J.starts.length,ratio:V})}if(t.progress(f.length,f.length,"done"),Q.length>0&&t.note(`${Q.length.toLocaleString()} ${Q.length===1?"sequence was":"sequences were"} not placed — not in the reference, or shorter than four skew windows: ${Q.slice(0,6).join(", ")}${Q.length>6?", …":""}.`),E.length===0)return[];i===null&&t.note("No coverage track was chosen, so there is no ori/ter ratio and no coverage step.");const m=E.filter(N=>N.topology==="linear").length;m>0&&t.note(`${m.toLocaleString()} ${m===1?"sequence was":"sequences were"} read as linear. A bacterial chromosome is usually circular — tick it in the Chromosomes table and run this again, or the origin at its first base is split between its two ends.`);const w=[{kind:"intervals",id:"oriter-loci",label:`Origin and terminus · ${t.inputs.labels?.[e]??"reference"}`,payload:{kind:"features",data:h.finish()},noun:{one:"locus",many:"loci"},display:"lane",look:"point"}];d>0&&w.push({kind:"intervals",id:"oriter-pars",label:`parS sites · ${A.parS.pattern}`,payload:{kind:"features",data:u.finish()},noun:{one:"site",many:"sites"},display:"lane",look:"point"}),C>0&&w.push({kind:"intervals",id:"oriter-mats",label:`matS sites · ${A.matS.pattern}`,payload:{kind:"features",data:I.finish()},noun:{one:"site",many:"sites"},display:"lane",look:"point"});const y=t.framing.binsize;if(B.size>0&&y>0&&c.length>0){const N=c.reduce((F,R)=>F+Math.max(1,Math.ceil(R.length/y)),0),k=new Float32Array(N).fill(Number.NaN);let b=0;for(const F of c){const R=Math.max(1,Math.ceil(F.length/y)),v=B.get(F.name);if(v!==void 0)for(let x=0;x<R;x++)k[b+x]=v(Math.min(F.length-1,(x+.5)*y));b+=R}const D=t.inputs.labels?.[i??""]??"coverage";w.push({kind:"profile",id:"oriter-coverage-fit",label:`${D} · spline fit`,values:k,extent:[0,N],binsize:y,unit:""})}return w.push({kind:"table",id:"oriter-table",label:"Origin and terminus per sequence",columns:[{key:"sequence",label:"sequence",kind:"text"},{key:"length",label:"length",kind:"number"},{key:"topology",label:"read as",kind:"text"},{key:"ori",label:"ori",kind:"number",hint:"Centre of the origin locus, 1-based."},{key:"ter",label:"ter",kind:"number",hint:"Centre of the terminus locus, 1-based."},{key:"rule",label:"terminus placed by",kind:"text"},{key:"parS",label:"parS",kind:"number",hint:"Sites found on this sequence."},{key:"parSCluster",label:"in cluster",kind:"number",hint:"parS sites within an eighth of the sequence of the densest one."},{key:"matS",label:"matS",kind:"number",hint:"Sites found on this sequence."},{key:"ratio",label:"ori/ter",kind:"number",digits:2,hint:"Highest over lowest smoothed coverage: copies of the origin per copy of the terminus."}],rows:E}),w};function GA(t,e,n){const A=t.contigs.indexOf(e);if(A<0)return[];const s=[];for(let r=t.contigAt[A];r<t.contigAt[A+1];r++){const o=t.start[r],i=t.end[r];if(i<=o)continue;const a=s[s.length-1];a!==void 0&&o<=a[1]?a[1]=Math.max(a[1],i):s.push([o,i])}return s}function $r(t){let e=0;for(const[n,A]of t)e+=A-n;return e}function NI(t,e){let n=0,A=0,s=0;for(;A<t.length&&s<e.length;){const r=Math.max(t[A][0],e[s][0]),o=Math.min(t[A][1],e[s][1]);o>r&&(n+=o-r),t[A][1]<e[s][1]?A++:s++}return n}function Yr(t,e,n,A){const s=t.contigs.indexOf(e);if(s<0||n.length===0)return 0;let r=0,o=0;for(let i=t.contigAt[s];i<t.contigAt[s+1];i++){const a=t.start[i],c=t.end[i],l=c-a;if(l<=0)continue;for(;o<n.length&&n[o][1]<=a;)o++;let g=0;for(let f=o;f<n.length&&n[f][0]<c;f++)g+=Math.max(0,Math.min(c,n[f][1])-Math.max(a,n[f][0]));g/l>=A&&g>0&&r++}return r}function sa(t,e,n){const A=new Set([...t.contigs,...e.contigs]);let s=0,r=0,o=0,i=0,a=0;for(const l of A){const g=GA(t,l,n.minFraction),f=GA(e,l,n.minFraction);s+=$r(g),r+=$r(f),o+=NI(g,f),i+=Yr(t,l,f,n.minFraction),a+=Yr(e,l,g,n.minFraction)}const c=s+r-o;return{basesA:s,basesB:r,intersection:o,union:c,jaccard:c>0?o/c:Number.NaN,featuresAHit:i,featuresBHit:a,featuresA:t.length,featuresB:e.length}}function kI(t,e,n,A,s){let r=0,o=0,i=0,a=0,c=0,l=Number.NaN,g=Number.NaN;const f=()=>{if(!Number.isNaN(l)){for(o+=g-l;c<A.length&&A[c][1]<=l;)c++;for(let h=c;h<A.length&&A[h][0]<g;h++)r+=Math.min(g,A[h][1])-Math.max(l,A[h][0])}};for(let h=0;h<n.length;h++){const u=n[h],I=t[u],d=I+e[u];for(;a<A.length&&A[a][1]<=I;)a++;let C=0;for(let B=a;B<A.length&&A[B][0]<d;B++)C+=Math.max(0,Math.min(d,A[B][1])-Math.max(I,A[B][0]));const E=d-I;E>0&&C>0&&C/E>=s&&i++,Number.isNaN(l)?(l=I,g=d):I<=g?g=Math.max(g,d):(f(),l=I,g=d)}return f(),{intersection:r,covered:o,hits:i}}function cA(t,e){const n=e.length;let A=0;for(let c=0;c<n;c++)A+=e[c];const s=n>0?A/n:Number.NaN;let r=0;for(let c=0;c<n;c++)r+=(e[c]-s)**2;const o=n>1?Math.sqrt(r/(n-1)):Number.NaN;let i=0,a=0;for(let c=0;c<n;c++)e[c]>=t&&i++,e[c]<=t&&a++;return{observed:t,mean:s,sd:o,z:o>0?(t-s)/o:Number.NaN,fold:s>0?t/s:Number.NaN,pEnriched:(i+1)/(n+1),pDepleted:(a+1)/(n+1)}}function bI(t,e,n){const A=sa(t,e,{minFraction:n.minFraction}),s=[],r=[],o=[];for(const I of t.contigs){const d=t.contigs.indexOf(I),C=[];let E=0;for(let m=t.contigAt[d];m<t.contigAt[d+1];m++){const p=t.end[m]-t.start[m];p<=0||(C.push(p),E=Math.max(E,t.end[m]))}if(C.length===0)continue;let Q=n.lengthOf(I);if(Q===void 0||Q<=0){const m=e.contigs.indexOf(I);let p=E;if(m>=0)for(let w=e.contigAt[m];w<e.contigAt[m+1];w++)p=Math.max(p,e.end[w]);Q=p,r.push(I)}if(!Number.isFinite(Q)||Q<=0){o.push(I);continue}s.push({contig:I,length:Q,lengths:C,runs:GA(e,I)})}if(s.length===0)return null;const i=Math.max(1,Math.trunc(n.iterations)),a=zi(n.seed),c=new Float64Array(i),l=new Float64Array(i),g=new Float64Array(i);let f=0;for(const I of s)f=Math.max(f,I.lengths.length);const h=new Float64Array(f),u=new Int32Array(f);for(let I=0;I<i;I++){if(n.cancelled?.()===!0)return null;let d=0,C=0,E=0;for(const Q of s){const m=Q.lengths.length;for(let y=0;y<m;y++){const N=Math.max(0,Q.length-Q.lengths[y]);h[y]=Math.floor(a()*(N+1)),u[y]=y}const p=u.subarray(0,m);p.sort((y,N)=>h[y]-h[N]);const w=kI(h,Q.lengths,p,Q.runs,n.minFraction);d+=w.intersection,C+=w.covered,E+=w.hits}l[I]=d,g[I]=E;const B=C+A.basesB-d;c[I]=B>0?d/B:Number.NaN,n.onProgress?.(I+1,i)}return{iterations:i,jaccard:cA(A.jaccard,c),intersection:cA(A.intersection,l),featuresHit:cA(A.featuresAHit,g),assumedLengths:r,droppedContigs:o}}const DI=async t=>{const e=ne(t.inputs.features,t.params,"a"),n=ne(t.inputs.features,t.params,"b"),A=e.value,s=n.value;if(A===void 0||s===void 0){const u=[e,n].filter(d=>d.value===void 0),I=u.filter(d=>d.chosen).length;return t.note(I===u.length?`The interval ${u.length===2?"sets":"set"} chosen ${u.length===2?"are":"is"} no longer loaded. Re-open the file, or pick another.`:`Two interval sets are needed and ${u.length===2&&I===0?"neither has":"one has not"} been chosen. Load two BED files, or a BED and a GTF, and pick one in each box.`),[]}t.progress(0,1,"comparing");const r=sa(A,s,{minFraction:Math.max(0,Math.min(1,T(t.params,"minFraction",1e-6)))});t.progress(1,1,"done"),Number.isFinite(r.jaccard)||t.note("Neither set covers any bases, so there is nothing to compare.");const i=[{kind:"table",id:"overlap",label:"Overlap",columns:[{key:"measure",label:"Measure",kind:"text"},{key:"value",label:"Value",kind:"number",digits:4},{key:"note",label:"Note",kind:"text"}],rows:[{measure:"Jaccard (bases)",value:r.jaccard,note:"Symmetric; 1 is identical."},{measure:"Shared bases",value:r.intersection,note:""},{measure:"Bases in either",value:r.union,note:""},{measure:"Bases in the first",value:r.basesA,note:"After merging its own overlaps."},{measure:"Bases in the second",value:r.basesB,note:"After merging its own overlaps."},{measure:"First set hit",value:r.featuresA===0?Number.NaN:r.featuresAHit/r.featuresA,note:`${r.featuresAHit.toLocaleString()} of ${r.featuresA.toLocaleString()} features.`},{measure:"Second set hit",value:r.featuresB===0?Number.NaN:r.featuresBHit/r.featuresB,note:`${r.featuresBHit.toLocaleString()} of ${r.featuresB.toLocaleString()} features.`}]}];if(!Lt(t.params,"shuffle",!1))return i;const a=st(t.params,"shuffleWhich","a")!=="b",c=Math.max(20,Math.trunc(T(t.params,"iterations",1e3)));t.progress(0,c,"shuffling");const l=bI(a?A:s,a?s:A,{minFraction:Math.max(0,Math.min(1,T(t.params,"minFraction",1e-6))),iterations:c,seed:T(t.params,"seed",1),lengthOf:u=>t.lengthOf(u),cancelled:()=>t.cancelled(),onProgress:(u,I)=>t.progress(u,I,"shuffling")});if(t.throwIfCancelled(),l===null)return t.note("The set chosen to move occupies no sequence this session knows a length for, so there was nothing to shuffle it within. Load the assembly — a chrom.sizes, or the map itself."),i;l.assumedLengths.length>0&&t.note(`${l.assumedLengths.length.toLocaleString()} sequence${l.assumedLengths.length===1?" has":"s have"} no known length, so the null was drawn over the furthest position either set reaches there — which is shorter than the sequence and overstates the enrichment. ${l.assumedLengths.slice(0,6).join(", ")}${l.assumedLengths.length>6?", …":""}.`),l.droppedContigs.length>0&&t.note(`${l.droppedContigs.length.toLocaleString()} sequence${l.droppedContigs.length===1?"":"s"} could not be shuffled at all and ${l.droppedContigs.length===1?"is":"are"} left out of the null: ${l.droppedContigs.slice(0,6).join(", ")}${l.droppedContigs.length>6?", …":""}.`);const g=a?"first":"second",f=(u,I,d)=>({measure:u,observed:I.observed,expected:I.mean,fold:I.fold,z:I.z,p:I.observed>=I.mean?I.pEnriched:I.pDepleted,tail:I.observed>=I.mean?"enriched":"depleted",digits:d}),h=[f("Jaccard (bases)",l.jaccard,4),f("Shared bases",l.intersection,0),f(`Features of the ${g} set hit`,l.featuresHit,0)].map(({digits:u,...I})=>I);return i.push({kind:"table",id:"overlap-null",label:`Against ${l.iterations.toLocaleString()} shuffles of the ${g} set`,columns:[{key:"measure",label:"Measure",kind:"text"},{key:"observed",label:"Observed",kind:"number",digits:4},{key:"expected",label:"Expected",kind:"number",digits:4,hint:"Mean of the null."},{key:"fold",label:"Fold",kind:"number",digits:2,hint:"Observed over expected."},{key:"z",label:"z",kind:"number",digits:2},{key:"p",label:"p",kind:"number",digits:5,hint:`Permutation p on the tail the observation fell on, with Phipson and Smyth’s +1: the smallest this run can report is ${(1/(l.iterations+1)).toPrecision(2)}.`},{key:"tail",label:"Tail",kind:"text"}],rows:h}),i},$t={maxIter:3e3,convergenceEps:1e-6,start:[.1,1,.2,.5],pseudoValueEps:1e-8,finalPseudoValueEps:1e-12,emStepsPerRound:30},Ct=[0,.2,.1,.01],ee=[20,20,.99,.99],Or={min:Ct,max:ee};class se extends Error{constructor(e){super(e),this.name="IdrError"}}const In=new Float64Array(1),_r=new Int32Array(In.buffer),ra=new Uint8Array(Float64Array.of(1).buffer)[7]===63?1:0,MI=1-ra,Kr=.8450629115104675,FI=.1283791670955126,SI=1.0270333367641007,Fe=[.12837916709551256,-.3250421072470015,-.02848174957559851,-.005770270296489442,-23763016656650163e-21],Se=[.39791722395915535,.0650222499887673,.005081306281875766,.00013249473800432164,-3960228278775368e-21],zt=[-.0023621185607526594,.41485611868374833,-.3722078760357013,.31834661990116175,-.11089469428239668,.035478304325618236,-.002166375594868791],le=[.10642088040084423,.540397917702171,.07182865441419627,.12617121980876164,.01363708391202905,.011984499846799107],Tt=[-.009864944034847148,-.6938585727071818,-10.558626225323291,-62.375332450326006,-162.39666946257347,-184.60509290671104,-81.2874355063066,-9.814329344169145],Jt=[19.651271667439257,137.65775414351904,434.56587747522923,645.3872717332679,429.00814002756783,108.63500554177944,6.570249770319282,-.0604244152148581],Xt=[-.0098649429247001,-.799283237680523,-17.757954917754752,-160.63638485582192,-637.5664433683896,-1025.0951316110772,-483.5191916086514],Vt=[30.33806074348246,325.7925129965739,1536.729586084437,3199.8582195085955,2553.0504064331644,474.52854120695537,-22.44095244658582];function qr(t){In[0]=t;const e=_r[ra],n=e&2147483647;if(n>=2146435072)return 1-(e>>>31<<1)+1/t;if(n<1072365568){if(n<1043333120)return n<8388608?.125*(8*t+SI*t):t+FI*t;const c=t*t,l=Fe[0]+c*(Fe[1]+c*(Fe[2]+c*(Fe[3]+c*Fe[4]))),g=1+c*(Se[0]+c*(Se[1]+c*(Se[2]+c*(Se[3]+c*Se[4])))),f=l/g;return t+t*f}if(n<1072955392){const c=Math.abs(t)-1,l=zt[0]+c*(zt[1]+c*(zt[2]+c*(zt[3]+c*(zt[4]+c*(zt[5]+c*zt[6]))))),g=1+c*(le[0]+c*(le[1]+c*(le[2]+c*(le[3]+c*(le[4]+c*le[5])))));return e>=0?Kr+l/g:-Kr-l/g}if(n>=1075314688)return e>=0?1-1e-300:1e-300-1;const A=Math.abs(t),s=1/(A*A);let r,o;n<1074191214?(r=Tt[0]+s*(Tt[1]+s*(Tt[2]+s*(Tt[3]+s*(Tt[4]+s*(Tt[5]+s*(Tt[6]+s*Tt[7])))))),o=1+s*(Jt[0]+s*(Jt[1]+s*(Jt[2]+s*(Jt[3]+s*(Jt[4]+s*(Jt[5]+s*(Jt[6]+s*Jt[7])))))))):(r=Xt[0]+s*(Xt[1]+s*(Xt[2]+s*(Xt[3]+s*(Xt[4]+s*(Xt[5]+s*Xt[6]))))),o=1+s*(Vt[0]+s*(Vt[1]+s*(Vt[2]+s*(Vt[3]+s*(Vt[4]+s*(Vt[5]+s*Vt[6]))))))),In[0]=A,_r[MI]=0;const i=In[0],a=Math.exp(-i*i-.5625)*Math.exp((i-A)*(i+A)+r/o);return e>=0?1-a/A:a/A-1}function dn(t,e,n,A){const s=(t-e)/n;return .5*A*qr(s/Math.SQRT2)+.5*(1-A)*qr(t/Math.SQRT2)+.5}function Hr(t,e,n,A,s,r,o){let i=0;for(let a=0;a<1e3;a++){i=s+(r-s)/2;const c=dn(i,e,n,A);if(Math.abs(c-t)<o)return i;c<t?s=i:r=i}return i}function UA(t,e,n,A,s,r){const o=Pr(t.length,n,A,s,r),i=e.length===t.length?o:Pr(e.length,n,A,s,r);return[Wr(t,o),Wr(e,i)]}function Wr(t,e){const n=new Float64Array(t.length);for(let A=0;A<t.length;A++)n[A]=e[t[A]];return n}function Pr(t,e,n,A,s){const r=new Float64Array(t);if(t===0)return r;const o=t+1,i=1/o;let a=0<=e?0:e;for(;dn(a,e,n,A)>i;)a-=1;let c=0>=e?0:e;for(;dn(c,e,n,A)<1-i;)c+=1;a=Hr(i,e,n,A,a,c,s),r[0]=a;for(let l=1;l<t;l++){const g=(l+1)/o;dn(c,e,n,A)<g&&(c+=10);const f=Hr(g,e,n,A,a,c,s);r[l]=f,a=f,c=a+2*(f-r[l-1])}return r}class oa{constructor(e,n){this.z1=e,this.z2=n,this.n=e.length,this.noise=new Float64Array(this.n),this.signal=new Float64Array(this.n),this.terms=new Float64Array(this.n),zr(0,1,0,e,n,this.noise)}n;noise;signal;terms;at=[Number.NaN,Number.NaN,Number.NaN];logLik(e){this.signalAt(e);const n=e[3];for(let A=0;A<this.n;A++)this.terms[A]=Math.log(n*this.signal[A]+(1-n)*this.noise[A]);return Bt(this.terms)}membership(e){this.signalAt(e);const n=e[3],A=new Float64Array(this.n);for(let s=0;s<this.n;s++){const r=n*this.signal[s];A[s]=r/(r+(1-n)*this.noise[s])}return A}signalAt(e){const n=this.at;e[0]===n[0]&&e[1]===n[1]&&e[2]===n[2]||(zr(e[0],e[1],e[2],this.z1,this.z2,this.signal),this.at=[e[0],e[1],e[2]])}}function zr(t,e,n,A,s,r){const o=-1.837877-Math.log(e)-Math.log(e)-.5*Math.log(1-n*n),i=2*n,a=2*(1-n*n);for(let c=0;c<A.length;c++){const l=(A[c]-t)/e,g=(s[c]-t)/e;r[c]=Math.exp(o-(l*l-i*l*g+g*g)/a)}}function RI(t,e){const{n,z1:A,z2:s}=t,r=t.membership(e),o=Bt(r),i=new Float64Array(n);for(let I=0;I<n;I++)i[I]=r[I]*A[I];const a=Bt(i)/o;for(let I=0;I<n;I++)i[I]=r[I]*s[I];const c=Bt(i)/o,l=(a+c)/2;for(let I=0;I<n;I++){const d=A[I]-l;i[I]=r[I]*(d*d)}const g=Bt(i);for(let I=0;I<n;I++){const d=s[I]-l;i[I]=r[I]*(d*d)}const f=Bt(i),h=Math.sqrt((g+f)/(2*o));for(let I=0;I<n;I++)i[I]=r[I]*(A[I]-l)*(s[I]-l);const u=2*Bt(i)/(g+f);return[l,h,u,o/n]}function ia(t){const e=[t[0],t[1],t[2],t[3]];let n=!1;return e[0]<Ct[0]&&(e[0]=Ct[0],n=!0),e[1]<Ct[1]&&(e[1]=Ct[1],n=!0),e[2]<Ct[2]?(e[2]=Ct[2],n=!0):e[2]>ee[2]&&(e[2]=ee[2],n=!0),e[3]<Ct[3]?(e[3]=Ct[3],n=!0):e[3]>ee[3]&&(e[3]=ee[3],n=!0),{theta:e,changed:n}}function LI(t,e,n,A){let s=e,r=t.logLik(s),o=[e[0],e[1],e[2],e[3]];for(let i=0;i<n;i++){const a=ia(RI(t,s));o=a.theta;const c=t.logLik(o);if(a.changed)return{theta:o,changed:!0};if(!(c+1e-6>=r))throw new se("An EM step lowered the likelihood, which stops idr’s own fit.");if(c-r<A)return{theta:o,changed:!1};s=o,r=c}return{theta:o,changed:!1}}function xI(t,e,n,A=1e-5,s=500){if(!Number.isFinite(e)||!Number.isFinite(n))throw new se("Optimization bounds must be finite scalars.");if(e>n)throw new se("The lower bound exceeds the upper bound.");const r=Math.sqrt(22e-17),o=.5*(3-Math.sqrt(5));let i=e,a=n,c=i+o*(a-i),l=c,g=c,f=0,h=0,u=g,I=t(u),d=1,C=I,E=I,B=.5*(i+a),Q=r*Math.abs(g)+A/3,m=2*Q;for(;Math.abs(g-B)>m-.5*(a-i);){let p=!0;if(Math.abs(h)>Q){p=!1;let N=(g-l)*(I-C),k=(g-c)*(I-E),b=(g-c)*k-(g-l)*N;if(k=2*(k-N),k>0&&(b=-b),k=Math.abs(k),N=h,h=f,Math.abs(b)<Math.abs(.5*k*N)&&b>k*(i-g)&&b<k*(a-g)){if(f=(b+0)/k,u=g+f,u-i<m||a-u<m){const D=Math.sign(B-g)+(B-g===0?1:0);f=Q*D}}else p=!0}p&&(h=g>=B?i-g:a-g,f=o*h);const w=Math.sign(f)+(f===0?1:0);u=g+w*Math.max(Math.abs(f),Q);const y=t(u);if(d+=1,y<=I?(u>=g?i=g:a=g,c=l,C=E,l=g,E=I,g=u,I=y):(u<g?i=u:a=u,y<=E||l===g?(c=l,C=E,l=u,E=y):(y<=C||c===g||c===l)&&(c=u,C=y)),B=.5*(i+a),Q=r*Math.abs(g)+A/3,m=2*Q,d>=s)break}return g}function GI(t,e,n){const A=[e[0],e[1],e[2],e[3]],s=e[n],r=c=>(A[n]=s+c,-t.logLik(A));if(!(s>=Ct[n])||!(s<=ee[n]))throw new se("A coordinate-ascent step started outside idr’s parameter box.");const o=xI(r,Ct[n]-s,ee[n]-s),i=-r(0),a=-r(o);return a>i?(e[n]+=o,a):i}function UI(t,e,n,A){let s=t.logLik(e),r=[e[0],e[1],e[2],e[3]],o=s;for(let i=0;i<n;i++){for(let c=0;c<4;c++)o=GI(t,r,c);const a=ia(r);if(a.changed)throw new se("Coordinate ascent left idr’s parameter box, which stops idr’s own fit.");if(r=a.theta,!(o+1e-6>=s))throw new se("A coordinate-ascent round lowered the likelihood, which stops idr’s own fit.");if(o-s<A)return r;s=o}return r}async function vI(t,e,n={}){const A=n.eps??$t.convergenceEps,s=n.maxIter??$t.maxIter,r=$t.pseudoValueEps,o=n.start??$t.start;let i=[o[0],o[1],o[2],o[3]],[a,c]=UA(t,e,i[0],i[1],i[3],r),l=!1,g=0;const f=new Float64Array(t.length);for(let h=0;h<s;h++){g=h+1;const u=i,I=new oa(a,c),d=LI(I,u,$t.emStepsPerRound,A/10);i=d.theta,d.changed&&(l=!0,i=UI(I,u,$t.emStepsPerRound,A/10));const C=Bt([Math.abs(i[0]-u[0]),Math.abs(i[1]-u[1]),Math.abs(i[2]-u[2]),Math.abs(i[3]-u[3])]),E=a,B=c;[a,c]=UA(t,e,i[0],i[1],i[3],r);for(let p=0;p<f.length;p++)f[p]=Math.abs(E[p]-a[p]);const Q=SA(f);for(let p=0;p<f.length;p++)f[p]=Math.abs(B[p]-c[p]);const m=Q+SA(f);if(n.between!==void 0&&await n.between(g),h>3&&C<A&&m<A)break}return{theta:i,rounds:g,coordinateAscent:l}}function TI(t,e,n){const A=$t.finalPseudoValueEps,[s,r]=UA(e,n,t[0],t[1],t[3],A),o=new oa(s,r).membership(t),i=$t.convergenceEps,a=new Float64Array(o.length);for(let c=0;c<a.length;c++){let l=1-o[c];s[c]+r[c]<0&&(l=1),a[c]=l<i?i:l>1?1:l}return a}function JI(t){const e=t.length,n=Array.from({length:e},(o,i)=>i);n.sort((o,i)=>t[o]-t[i]||o-i);const A=new Float64Array(e);let s=0,r=0;for(;r<e;){let o=r;for(;o<e&&t[n[o]]===t[n[r]];)s+=t[n[o]],o++;const i=s/o;for(let a=r;a<o;a++)A[n[a]]=i;r=o}return A}function vA(t){return-Math.log10(Math.max(1e-5,t))}function Xr(t){const e=t.length,n=Array.from({length:e},(s,r)=>r);n.sort((s,r)=>t[s]-t[r]||s-r);const A=new Int32Array(e);for(let s=0;s<e;s++)A[n[s]]=s;return A}const sn={width:150,times:3,minWidth:75,truncate:1e5},$I=[-1/560,8/315,-1/5,8/5,-205/72,8/5,-1/5,8/315,-1/560],YI=1e6,OI=1e-10;function _I(t,e){let n=Float64Array.from($I);const A=new Float64Array(t).fill(1/t);for(let o=0;o<e;o++)n=KI(n,A);const s=new Float64Array(n.length);for(let o=0;o<n.length;o++)s[o]=YI*n[n.length-1-o];const r=new Float64Array(s.length+1);for(let o=0;o<s.length;o++)r[o+1]=r[o]+s[o];return{width:t,times:e,values:s,cumulative:r}}function KI(t,e){const n=new Float64Array(t.length+e.length-1);for(let A=0;A<n.length;A++){let s=0;const r=Math.max(0,A-(e.length-1)),o=Math.min(A,t.length-1);for(let i=r;i<=o;i++)s+=t[i]*e[A-i];n[A]=s}return n}function Ns(t,e){return Math.min(e,t.values.length)-1>>1}function qI(t,e){const n=Ns(t,e);return{left:t.values.length-1-n,right:n}}function HI(t,e,n,A,s){const r=[],o=[],i=[],a=(l,g,f)=>{const h=i.length-1;if(h>=0&&o[h]===l&&aa(i[h],f)){o[h]=g;return}r.push(l),o.push(g),i.push(f)};let c=A;for(let l=0;l<t.length&&c<s;l++){const 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c.sort(i),Int32Array.from(c)}class jI{constructor(e,n,A={}){this.tracks=e,this.limit=n,this.scores=Array.from({length:e},()=>new Float64Array(1024)),this.floor=new Float64Array(e).fill(Number.NEGATIVE_INFINITY),A.prune===!1&&(this.holdAll=!0),this.below=A.below===!0?new Float64Array(1024):null}size=0;contigs=[];starts=new Int32Array(1024);ends=new Int32Array(1024);modes=new Int32Array(1024);flats=new Uint8Array(1024);scores;floor;seen=0;dropped=0;holdAll=!1;below;belowSize=0;add(e,n){this.seen++;let A=this.holdAll;for(let r=0;r<this.tracks;r++){const o=e.scores[r][n];o!==o&&!this.holdAll&&(this.holdAll=!0,A=!0),o>=this.floor[r]&&(A=!0)}if(!A){this.drop(e.scores[0][n],e.flat[n]);return}this.size===this.starts.length&&this.grow();const s=this.size++;this.contigs[s]=e.contig,this.starts[s]=e.starts[n],this.ends[s]=e.ends[n],this.modes[s]=e.modes[n],this.flats[s]=e.flat[n];for(let r=0;r<this.tracks;r++)this.scores[r][s]=e.scores[r][n];!this.holdAll&&this.size>=2*this.tracks*this.limit+1024&&this.prune()}finish(){this.holdAll||this.prune();const e=this.size,n={contig:this.contigs.slice(0,e),starts:this.starts.slice(0,e),ends:this.ends.slice(0,e),modes:this.modes.slice(0,e),flat:this.flats.slice(0,e),scores:this.scores.map(A=>A.slice(0,e))};return{...n,tested:ZI(n.contig,n.starts,n.ends,n.scores,this.limit),below:this.below===null?new Float64Array(0):this.below.slice(0,this.belowSize),exact:!(this.holdAll&&this.dropped>0)}}prune(){if(this.seen<this.limit)return;const e=this.size;for(let A=0;A<this.tracks;A++){const s=this.scores[A].slice(0,e).sort();this.floor[A]=s[e-this.limit]}let n=0;for(let A=0;A<e;A++){let s=!1;for(let r=0;r<this.tracks;r++)this.scores[r][A]>=this.floor[r]&&(s=!0);if(!s){this.drop(this.scores[0][A],this.flats[A]);continue}if(n!==A){this.contigs[n]=this.contigs[A],this.starts[n]=this.starts[A],this.ends[n]=this.ends[A],this.modes[n]=this.modes[A],this.flats[n]=this.flats[A];for(let r=0;r<this.tracks;r++)this.scores[r][n]=this.scores[r][A]}n++}this.size=n,this.contigs.length=n}drop(e,n){if(this.dropped++,!(this.below===null||!(e>0)||n===1)){if(this.belowSize===this.below.length){const A=new Float64Array(this.below.length*2);A.set(this.below),this.below=A}this.below[this.belowSize++]=e}}grow(){const e=n=>{const A=new n.constructor(n.length*2);return A.set(n),A};this.starts=e(this.starts),this.ends=e(this.ends),this.modes=e(this.modes),this.flats=e(this.flats),this.scores=this.scores.map(e)}}function td(t,e,n,A,s){return A>0?[Math.max(0,n-A),Math.min(s,n+A+1)]:[t,e]}function la(t){return-(Math.log(t)/Math.log(10))}const ga=[.001,.005,.01,.05,.1,.2],lA="0.05";function fa(t){return typeof t.replicate=="string"&&t.replicate!==""}const ed="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",nd=8,Ad=-1,sd=-2;let ge;function rd(){if(ge!==void 0)return ge;ge=null;try{if(typeof WebAssembly>"u")return null;const t=atob(ed),e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)e[n]=t.charCodeAt(n);WebAssembly.validate(e)&&(ge=new WebAssembly.Module(e))}catch{ge=null}return ge}class TA extends Error{constructor(){super("The peak-calling kernel ran out of memory."),this.name="KernelMemoryError"}}class od{size=0;starts=new Int32Array(1024);ends=new Int32Array(1024);modes=new Int32Array(1024);flats=new Uint8Array(1024);scores;constructor(e){this.scores=Array.from({length:e},()=>new Float64Array(1024))}take(e,n,A){if(A===0)return;for(;this.size+A>this.starts.length;)this.grow();const s=e.buffer,r=n.scan_region_capacity();this.starts.set(new Int32Array(s,n.scan_region_starts()>>>0,A),this.size),this.ends.set(new Int32Array(s,n.scan_region_ends()>>>0,A),this.size),this.modes.set(new Int32Array(s,n.scan_region_modes()>>>0,A),this.size),this.flats.set(new Uint8Array(s,n.scan_region_flats()>>>0,A),this.size);const o=n.scan_regions()>>>0;this.scores.forEach((i,a)=>i.set(new Float64Array(s,o+a*r*8,A),this.size)),this.size+=A}grow(){const e=n=>{const A=new n.constructor(n.length*2);return A.set(n),A};this.starts=e(this.starts),this.ends=e(this.ends),this.modes=e(this.modes),this.flats=e(this.flats),this.scores=this.scores.map(e)}}class ks{constructor(e,n,A,s){this.memory=e,this.exports=n,this.contig=A,this.tracks=s,this.collected=new od(s)}collected;static open(e,n,A,s,r){const o=rd();if(o===null||s<1||s>nd)return null;try{const i=new WebAssembly.Memory({initial:2}),c=new WebAssembly.Instance(o,{env:{memory:i}}).exports,l=e.values.length;if(c.scan_open(s,l,Ns(e,A),A,r)!==0)return null;const g=c.scan_kernel()>>>0;return new Float64Array(i.buffer,g,l).set(e.values),new Float64Array(i.buffer,g+l*8,l+1).set(e.cumulative),new ks(i,c,n,s)}catch{return null}}window(e,n,A,s,r){let o=0;for(let i=0;i<this.tracks;i++){const a=r[i];if(a===null){o|=1<<i;continue}const c=a.starts.length,l=this.exports.scan_input(i,c)>>>0;if(l===0)throw new TA;const g=this.memory.buffer;new Float64Array(g,l,c).set(a.values),new Int32Array(g,l+c*8,c).set(a.starts),new Int32Array(g,l+c*12,c).set(a.ends)}this.closed(this.exports.scan_window(e,n,A,s,o),e)}lastWindow(e){const n=this.memory.buffer;return{pooled:new Float64Array(n,this.exports.scan_pooled()>>>0,e).slice(),flat:new Uint8Array(n,this.exports.scan_flat()>>>0,e).slice(),own:Array.from({length:this.tracks},(A,s)=>new Float64Array(n,this.exports.scan_own(s)>>>0,e).slice())}}finish(){this.closed(this.exports.scan_finish(),-1);const{collected:e}=this,n=this.exports.scan_rose()===1?e.size:0;return{contig:this.contig,starts:e.starts.slice(0,n),ends:e.ends.slice(0,n),modes:e.modes.slice(0,n),scores:e.scores.map(A=>A.slice(0,n)),flat:e.flats.slice(0,n)}}closed(e,n){if(e===Ad)throw new TA;if(e===sd)throw new Error(`ConcaveScan: fed ${n} out of order`);if(e<0)throw new Error(`pooledRuns: a track does not cover a window at ${n}`);this.collected.take(this.memory,this.exports,e)}}const gA=1<<18,to=20,rn=2e4,eo=["#0072b2","#009e73"],id="#999999",ad=async t=>{const e=at(t.params,"signal");if(e===null)return t.note("No track was chosen. Load a bigWig and pick it under Track."),[];const n=fa(t.params)?at(t.params,"replicate"):null;if(n===e)return t.note("The replicate chosen is the track being called, and a track cannot test itself. Choose a second track, or none."),[];const A=n===null?[e]:[e,n],s=L=>t.inputs.labels?.[L]??L,r=Re(T(t.params,"width",sn.width),1,2e3),o=Re(T(t.params,"times",sn.times),0,10),i=Re(T(t.params,"minWidth",sn.minWidth),1,1e9),a=Re(T(t.params,"halfWidth",0),0,1e9),c=Re(T(t.params,"truncate",sn.truncate),1,1e9),l=ld(t),g=t.inputs.contigLengths??{},f=On(t.params,"sequences"),h=Object.keys(g).filter(L=>g[L]>0&&(f===null||f.includes(L)));if(h.length===0)return t.note(f!==null&&f.length===0?"No sequence is ticked, so there is nothing to call peaks on.":"This session knows no sequence lengths, so there is nothing to scan. Load a chrom.sizes, or the map itself."),[];const u=_I(r,o),I=L=>cd(t,A,h,g,u,{minWidth:i,truncate:c,below:n===null,prune:L});let d=await I(!0);if(typeof d!="string"&&!d.held.exact&&(d=await I(!1)),typeof d=="string")return t.note(d),[];const{held:C,found:E,n:B,perSequence:Q,absentOn:m}=d;for(let L=0;L<A.length;L++){if(m[L].length===h.length)return t.note(`${s(A[L])} has none of the ${h.length===1?"sequence":"sequences"} ticked. Check that it and the assembly name their sequences the same way.`),[];m[L].length>0&&t.note(`${s(A[L])} has no ${Qd(m[L])}. yapc reads a track that lacks a sequence as zeros there, so it lowers the mean the regions are called on, and ranks every region there last by it.`)}const p=`${u.values.length}-tap kernel: a ${r.toLocaleString()} bp window, ${o} ${o===1?"pass":"passes"}`;if(B===0)return t.note(`No concave region at least ${i.toLocaleString()} bp wide on ${h.length===1?h[0]:`${h.length} sequences`} (${p}). A wider smoothing window finds broader shapes; a narrower minimum keeps smaller ones.`),[];const{contig:w,starts:y,ends:N,modes:k,flat:b,scores:D,tested:F}=C;t.note(`${E.toLocaleString()} concave ${E===1?"region":"regions"} on ${h.length.toLocaleString()} ${h.length===1?"sequence":"sequences"} (${p}), ${B.toLocaleString()} at least ${i.toLocaleString()} bp wide`+(F.length<B?`, of which the ${F.length.toLocaleString()} strongest by each track’s curvature rank were kept.`:"."));let R=null,v=null,x=null;const Y=new Uint8Array(F.length).fill(1);if(n!==null)if(F.length<to)t.note(`IDR needs at least ${to} peaks to fit — its own command refuses fewer — and there ${F.length===1?"is 1":`are ${F.length}`}. They are reported untested, ranked by curvature.`);else{const L=Xr(on(D[0],F)),$=Xr(on(D[1],F)),Dt=so(on(D[0],F))+so(on(D[1],F));Dt>0&&t.note(`${Dt.toLocaleString()} ${Dt===1?"score ties":"scores tie"} with another: ranked by position, where yapc breaks a tie at random.`);try{R=await vI(L,$,{between:async P=>{t.progress(0,0,`IDR, round ${P}`),await Bs(),t.throwIfCancelled()}})}catch(P){throw P instanceof se?new Error(`IDR could not fit these two tracks, as idr itself could not: ${P.message}`):P}v=TI(R.theta,L,$),x=JI(v);const Ut=la(l);for(let P=0;P<F.length;P++)Y[P]=vA(x[P])>=Ut?1:0;t.note(gd(R,F.length,dd(Y),l))}else{let L=0;for(let $=0;$<F.length;$++)b[F[$]]!==0&&(Y[$]=0,L++);L>0&&t.note(`${L.toLocaleString()} of the candidates ${L===1?"is":"are"} flat — the signal constant across a whole kernel’s width inside, which yapc’s test counts as concave — and ${L===1?"is":"are"} left out, as IDR would leave ${L===1?"it":"them"} out of two replicates.`),t.note("One track, so no test of significance: yapc’s cut is IDR between two replicates. These are the strongest concave regions by curvature — choose a replicate to test them, or lower “keep the strongest” to the upper of the two populations in the figure.")}const J=new Map(h.map((L,$)=>[L,$])),K=[];for(let L=0;L<F.length;L++)Y[L]===1&&K.push(L);K.sort((L,$)=>(J.get(w[F[L]])??0)-(J.get(w[F[$]])??0)||y[F[L]]-y[F[$]]);const V=new et;let H=0,ht=0;for(const L of K){const $=F[L],[Dt,Ut]=td(y[$],N[$],k[$],a,g[w[$]]);a>0&&(Dt!==k[$]-a||Ut!==k[$]+a+1)&&H++;const P=[`summit ${(k[$]+1).toLocaleString("en-US")}`];P.push(`curvature ${A.map(($Q,sc)=>ro(D[sc][$])).join(" / ")}`),x!==null&&P.push(`IDR ${ro(x[L])}`),V.add(w[$],Dt,Ut,{name:`peak_${++ht}`,score:x!==null?vA(x[L]):D[0][$],cds:[k[$],k[$]+1],detail:P.join(ct)})}H>0&&t.note(`${H.toLocaleString()} ${H===1?"peak reaches":"peaks reach"} past a sequence end at this half-width and ${H===1?"is":"are"} cut at it; yapc writes the coordinate past the end.`),K.length===0&&t.note(`No peak passes IDR ≤ ${l}. A looser threshold keeps more; two tracks that are not replicates of one experiment will pass few at any.`);const Gt=[];K.length>0&&Gt.push({kind:"intervals",id:`peaks-${A.map(L=>L.replace(/[^A-Za-z0-9_]+/g,"_")).join("-")}`,label:n===null?`Peaks · ${s(e)} · no IDR`:`Peaks · ${s(e)} + ${s(n)} · IDR ≤ ${l}`,payload:{kind:"features",data:V.finish()},noun:{one:"peak",many:"peaks"},lane:{under:{entry:e}},display:"lane",look:"point"});const q=fd(A.map(s),D,F,Y,n!==null,b,C.below);return q!==null&&Gt.push(q),Gt.push(hd(h,g,Q,K.map(L=>w[F[L]]))),R!==null&&x!==null&&Gt.push(ud(x,l)),Lt(t.params,"perPeak",!1)&&Gt.push(Id({names:A.map(s),contig:w,starts:y,ends:N,modes:k,scores:D,tested:F,passes:Y,local:v,global:x,replicate:n!==null})),t.progress(1,1,"done"),Gt};async function cd(t,e,n,A,s,r){const o=n.reduce((h,u)=>h+A[u],0);let i=0;const a=new jI(e.length,r.truncate,{prune:r.prune,below:r.below}),c=e.map(()=>[]),l=new Map;let g=0,f=0;for(const h of n){const u=await ha(t,e,h,A[h],s,C=>{i+=C,t.progress(i,o,h)});if(typeof u=="string")return u;const{regions:I}=u;let d=0;for(let C=0;C<I.starts.length;C++)I.ends[C]-I.starts[C]<r.minWidth||(d++,a.add(I,C));g+=I.starts.length,f+=d,l.set(h,{regions:I.starts.length,wide:d}),u.absent.forEach((C,E)=>{C&&c[E].push(h)})}return{held:a.finish(),found:g,n:f,perSequence:l,absentOn:c}}async function ha(t,e,n,A,s,r,o="auto"){const{left:i,right:a}=qI(s,A),c=e.map(()=>!1),l=o==="js"?null:ks.open(s,n,A,e.length,gA);let g=null,f=0;try{for(let h=0;h<A;h+=gA){const u=Math.min(A,h+gA),I=Math.max(0,h-i),d=Math.min(A,u+a),C=[];for(let E=0;E<e.length;E++){if(c[E]){C.push(null);continue}const B=await t.sample(e[E],[{contig:n,start:I,end:d}],1);if(B.note!==void 0)return B.note;const Q=B.regions[0];Q===void 0&&(c[E]=!0),C.push(Q??null)}if(l!==null)l.window(h,u,I,d,C);else{const E=C.map(w=>w===null?WI(I,d):HI(w.starts,w.ends,w.values,I,d));g??=new jr(n,A,c);const B=new Uint8Array(u-h),Q=Vr(PI(E,I,d),s,A,h,u,B),m=e.length===1?null:XI(Q),p=m===null?[Q]:E.map(w=>Vr(w,s,A,h,u,void 0,m));g.feed(h,Q,p,B)}r(u-h),f+=u-h,await Bs(),t.throwIfCancelled()}}catch(h){if(!(h instanceof TA))throw h;return r(-f),ha(t,e,n,A,s,r,"js")}return l!==null?{regions:l.finish(),absent:c}:{regions:(g??new jr(n,A,c)).finish(),absent:c}}function ld(t){const e=Number(st(t.params,"idr",lA));return ga.includes(e)?e:(fa(t.params)&&t.note(`An IDR threshold of ${st(t.params,"idr","")} is not one yapc writes; ${lA} was used.`),Number(lA))}const no=["mean","spread","correlation","reproducible share"];function gd(t,e,n,A){const[s,r,o,i]=t.theta,a=`IDR fitted over ${e.toLocaleString()} peaks in ${t.rounds.toLocaleString()} rounds: μ ${s.toFixed(2)}, σ ${r.toFixed(2)}, ρ ${o.toFixed(2)}, reproducible share ${i.toFixed(2)}; ${n.toLocaleString()} pass IDR ≤ ${A}.`,c=[],l=g=>Number.isInteger(g)?String(g):g.toFixed(2);return t.theta.forEach((g,f)=>{const[h,u]=[Or.min[f],Or.max[f]];g<=h+1e-4*Math.max(1,h)?c.push(`the ${no[f]} at its floor of ${l(h)}`):g>=u-1e-4*Math.max(1,u)&&c.push(`the ${no[f]} at its ceiling of ${l(u)}`)}),c.length===0?a:`${a} The fit ended at the edge of IDR’s parameter box — ${c.join(", ")} — which is where two tracks that do not rank their peaks like replicates of one experiment put it. Read these IDRs as that, not as reproducibility.`}function fd(t,e,n,A,s,r,o){const i=[],a=new Uint8Array(r.length);for(const f of n)a[f]=1;for(let f=0;f<e.length;f++){const h=[],u=[];if(n.forEach((E,B)=>{const Q=e[f][E];!(Q>0)||!s&&r[E]===1||(A[B]===1?h.push(Q):u.push(Q))}),!s){for(let E=0;E<r.length;E++)a[E]===0&&e[f][E]>0&&r[E]===0&&u.push(e[f][E]);for(const E of o)u.push(E)}const I=e.length===1?"":`${t[f]} · `,d=s?`${I}passes IDR`:`${I}peaks`,C=s?`${I}fails IDR`:`${I}below the cut`;h.length>0&&i.push(Ao(d,h,eo[f]??eo[0])),u.length>0&&i.push(Ao(C,u,id))}if(i.length===0)return null;const c=i.flatMap(f=>Array.from(f.y)),l=Cd(c,.01);let g=Number.NEGATIVE_INFINITY;for(const f of c)f>g&&(g=f);return{kind:"curve",id:"peaks-curvature",label:"Curvature of every candidate",series:i,xLabel:"",yLabel:"Curvature (yapc score)",xScale:"linear",yScale:"log",...Number.isFinite(l)&&l>0&&g>l?{yDomain:[10**Math.floor(Math.log10(l)),10**Math.ceil(Math.log10(g))]}:{}}}function Ao(t,e,n){const A=Float64Array.from(e).sort();let s=A;if(A.length>rn){s=new Float64Array(rn);for(let r=0;r<rn;r++)s[r]=A[Math.round(r*(A.length-1)/(rn-1))]}return{name:t,x:Float64Array.from(s,(r,o)=>o),y:s,colour:n,n:e.length,mark:"violin"}}function hd(t,e,n,A){const s=new Map;for(const r of A)s.set(r,(s.get(r)??0)+1);return{kind:"table",id:"peaks-sequences",label:"Per sequence",columns:[{key:"sequence",label:"Sequence",kind:"text"},{key:"length",label:"Length",kind:"number"},{key:"regions",label:"Concave regions",kind:"number"},{key:"wide",label:"Wide enough",kind:"number"},{key:"peaks",label:"Peaks",kind:"number"},{key:"density",label:"Peaks per Mb",kind:"number",digits:1}],rows:t.map(r=>{const o=n.get(r)??{regions:0,wide:0},i=s.get(r)??0;return{sequence:r,length:e[r],regions:o.regions,wide:o.wide,peaks:i,density:i/e[r]*1e6}})}}function ud(t,e){const n=t.length;return{kind:"table",id:"peaks-idr",label:"IDR thresholds",columns:[{key:"threshold",label:"IDR ≤",kind:"text"},{key:"peaks",label:"Peaks",kind:"number"},{key:"share",label:"Share of tested",kind:"number",digits:3},{key:"drawn",label:"Drawn",kind:"text"}],rows:ga.map(A=>{const s=la(A);let r=0;for(let o=0;o<n;o++)vA(t[o])>=s&&r++;return{threshold:String(A),peaks:r,share:r/n,drawn:A===e?"yes":""}})}}function Id(t){const{names:e,contig:n,starts:A,ends:s,modes:r,scores:o,tested:i,passes:a,local:c,global:l}=t,g=[];return i.forEach((f,h)=>{const u={sequence:n[f],start:A[f],end:s[f],summit:r[f],width:s[f]-A[f]};o.forEach((I,d)=>{u[`curvature${d}`]=I[f]}),c!==null&&l!==null&&(u.local=c[h],u.idr=l[h],u.passes=a[h]===1?"yes":"no"),g.push(u)}),l!==null?g.sort((f,h)=>Number(f.idr)-Number(h.idr)):g.sort((f,h)=>Number(h.curvature0)-Number(f.curvature0)),{kind:"table",id:"peaks-list",label:t.replicate?"Every peak tested":"Every peak",columns:[{key:"sequence",label:"Sequence",kind:"text"},{key:"start",label:"Start",kind:"number",coordinate:"start"},{key:"end",label:"End",kind:"number",coordinate:"end"},{key:"summit",label:"Summit",kind:"number",coordinate:"start",hint:"The most concave base."},{key:"width",label:"Width",kind:"number"},...e.map((f,h)=>({key:`curvature${h}`,label:e.length===1?"Curvature":`Curvature · ${f}`,kind:"number",digits:2})),...c!==null?[{key:"local",label:"Local IDR",kind:"number",digits:4,scientific:!0},{key:"idr",label:"IDR",kind:"number",digits:4,scientific:!0},{key:"passes",label:"Passes",kind:"text"}]:[]],rows:g}}function Re(t,e,n){return Math.min(n,Math.max(e,Math.round(t)))}function on(t,e){const n=new Float64Array(e.length);for(let A=0;A<e.length;A++)n[A]=t[e[A]];return n}function dd(t){let e=0;for(const n of t)e+=n;return e}function so(t){const e=Float64Array.from(t).sort();let n=0;for(let A=1;A<e.length;A++)e[A]===e[A-1]&&n++;return n}function Cd(t,e){if(t.length===0)return Number.NaN;const n=Float64Array.from(t).sort(),A=e*(n.length-1),s=Math.floor(A),r=Math.min(n.length-1,s+1);return n[s]+(A-s)*(n[r]-n[s])}function ro(t){return Number.isFinite(t)?Number(t.toPrecision(4)).toLocaleString("en-US",{maximumSignificantDigits:4}):t>0?"∞":t<0?"−∞":"—"}function Qd(t){return t.length===1?t[0]:t.length<=3?`${t.slice(0,-1).join(", ")} and ${t[t.length-1]}`:`${t.slice(0,3).join(", ")} and ${(t.length-3).toLocaleString()} more`}const ua=[{name:"DpnII",site:"GATC",cut:0},{name:"HindIII",site:"AAGCTT",cut:1},{name:"NcoI",site:"CCATGG",cut:1},{name:"EcoRI",site:"GAATTC",cut:1},{name:"BglII",site:"AGATCT",cut:1},{name:"HinfI",site:"GANTC",cut:1},{name:"DdeI",site:"CTNAG",cut:1},{name:"MseI",site:"TTAA",cut:1},{name:"NlaIII",site:"CATG",cut:4},{name:"CviQI",site:"GTAC",cut:1},{name:"AluI",site:"AGCT",cut:2}],Bd={MboI:"DpnII",Sau3AI:"DpnII",Csp6I:"CviQI"},Sn={Arima:["DpnII","HinfI"]},Ed=(()=>{const t=new Map;for(const e of ua)t.set(e.name.toLowerCase(),e);for(const[e,n]of Object.entries(Bd)){const A=t.get(n.toLowerCase());A!==void 0&&t.set(e.toLowerCase(),A)}return t})();function an(t){return Ed.get(t.trim().toLowerCase())}function Rn(t){const e=t.trim().toLowerCase();return Object.keys(Sn).find(n=>n.toLowerCase()===e)}function Ia(t){return`${t.site.slice(0,t.cut)}^${t.site.slice(t.cut)}`}function md(t){return t.site.length-2*t.cut}const wd=1/256,oo=255;function io(t){let e=1;for(const n of t){let A=0;for(let s=n;s!==0;s&=s-1)A++;e*=A/4}return e}function pd(t){const e=t.toUpperCase().replace(/U/g,"T"),n=e.indexOf("^"),A=e.replace("^","");if(n<0){const r=Oe(A);return{refusal:Ye(r)?`“${t}” is neither an enzyme this knows nor a site in IUPAC letters with a ^ where it cuts.`:`“${t}” needs a ^ where the enzyme cuts the top strand, as in ^GATC or G^ANTC.`}}if(A.includes("^"))return{refusal:`“${t}” has more than one ^, and a site is cut in one place.`};const s=Oe(A);return Ye(s)?{refusal:s.reason}:io(s)>wd?{refusal:`“${t}” would cut every ${Math.round(1/io(s))} bases or so; a site needs at least the specificity of a four-base cutter.`}:{name:`${e.slice(0,n)}^${e.slice(n+1)}`,site:A,cut:n}}function yd(t,e){const n=t.trim();if(n===""||n==="none")return[];if(n!=="custom"){const i=Rn(n);if(i!==void 0)return Sn[i].map(c=>an(c));const a=an(n);return a===void 0?{refusal:`“${n}” is not an enzyme or a kit this knows. Pick one, or type its site under custom.`}:[a]}const A=e.split(/[\s,;]+/).filter(i=>i!=="");if(A.length===0)return{refusal:"Type an enzyme or a site, such as DpnII or G^ANTC."};const s=[],r=new Set,o=i=>{const a=`${i.site}^${i.cut}`;r.has(a)||(r.add(a),s.push(i))};for(const i of A){const a=Rn(i);if(a!==void 0){for(const g of Sn[a])o(an(g));continue}const c=an(i);if(c!==void 0){o(c);continue}const l=pd(i);if("refusal"in l)return l;o(l)}return s.length>oo?{refusal:`That is ${s.length} enzymes, and one digest takes ${oo} at most.`}:s}function Nd(t){return t.map(e=>e.name).join("+")}function kd(t){let e=0;for(const n of t)e=Math.max(e,n.site.length);return Math.max(0,e-1)}const ao=new Map;function bd(t){const e=`${t.site}^${t.cut}`,n=ao.get(e);if(n!==void 0)return n;const A=Oe(t.site);if(Ye(A))throw new Error(`${t.name}: ${A.reason}`);const s={motif:A,offset:t.cut};return ao.set(e,s),s}const Qe=256;function da(t,e,n,A,s){const r=t.subarray(0,e).sort();let o=0,i=Number.NaN;for(let c=0;c<r.length;c++){const l=Math.floor(r[c]/Qe);l===i||!(l>A&&l<s)||(i=l,r[o++]=r[c])}const a={top:new Int32Array(o),bottom:new Int32Array(o),enzyme:new Uint8Array(o)};for(let c=0;c<o;c++){const l=Math.floor(r[c]/Qe),g=r[c]-l*Qe;a.top[c]=l,a.bottom[c]=l+n[g],a.enzyme[c]=g}return a}function Dd(t,e,n=0){let A=new Float64Array(Math.max(16,t.length>>7)),s=0;e.forEach((o,i)=>{const a=bd(o),{hits:c}=ps(t,a.motif,{bothStrands:!0,offset:n});if(s+c.length>A.length){const l=new Float64Array(Math.max(A.length*2,s+c.length));l.set(A.subarray(0,s)),A=l}for(const l of c)A[s++]=(l.start+a.offset)*Qe+i});const r=Int32Array.from(e,md);return da(A,s,r,Number.NEGATIVE_INFINITY,Number.POSITIVE_INFINITY)}function Md(t,e){let n=0;for(const o of t)n+=o.top.length;const A=new Float64Array(n),s=new Int32Array(Qe);let r=0;for(const o of t)for(let i=0;i<o.top.length;i++)A[r++]=o.top[i]*Qe+o.enzyme[i],s[o.enzyme[i]]=o.bottom[i]-o.top[i];return da(A,r,s,0,e)}const Fd=16e6;[...ua.map(t=>({value:t.name,label:`${t.name} (${Ia(t)})`})),...Object.entries(Sn).map(([t,e])=>({value:t,label:`${t} (${e.join(" + ")})`}))];function Sd(t){const e=typeof t.enzyme=="string"?t.enzyme:"none",n=typeof t.sites=="string"?t.sites:"";return{choice:e,sites:n}}async function Rd(t,e,n={}){const A=n.contigs??t.contigs,s=kd(e),r=Math.max(1,Math.floor(n.piece??Fd)),o=t.read?.bind(t),i=A.reduce((l,g)=>l+g.length,0);let a=0;const c=[];for(const l of A){const g=o===void 0?t.bases(l.name):void 0;if(o===void 0&&g===void 0)continue;const f=g?.length??l.length,h=[];let u=!0;for(let I=0;I<f;I+=r){n.throwIfCancelled?.();const d=Math.min(f,I+r),C=Math.min(f,d+s),E=g!==void 0?g.subarray(I,C):await o?.(l.name,I,C);if(E===void 0){u=!1;break}h.push(Dd(E,e,I)),a+=d-I,n.progress?.(a,i,l.name)}u&&c.push({contig:l.name,length:f,cuts:Md(h,f)})}return c}function Ld(t,e){const n=Nd(e),A=Rn(t);return A===void 0?n:`${A} (${n})`}function xd(t,e){const n=Rn(t);return n!==void 0?n.replace(/[^A-Za-z0-9]/g,""):e.map(A=>A.name.replace(/\^/g,"_").replace(/[^A-Za-z0-9_]/g,"")).join("-")}const Gd=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to cut."),[];if(e===null)return t.note("No reference was chosen. Load a FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.read===void 0&&n.refusal!==void 0)return t.note(n.refusal),[];const{choice:A,sites:s}=Sd(t.params),r=yd(A,s);if(!Array.isArray(r))return t.note(r.refusal),[];if(r.length===0)return t.note("No enzyme was chosen, so there is nothing to cut."),[];const o=On(t.params,"sequences");if(o!==null&&o.length===0)return t.note("No sequence is ticked, so there is nothing to cut."),[];const i=Object.entries(t.inputs.contigLengths??{}).filter(([,Q])=>Q>0).map(([Q])=>Q),a=ji(n,o,i);if(a.length===0)return t.note("None of the ticked sequences is in this reference, so there is nothing to cut."),[];const c=a.length===n.contigs.length;t.progress(0,1,a.length===1?`cutting ${a[0].name}`:`cutting ${a.length.toLocaleString()} sequences`);const l=await Rd(n,r,{contigs:a,progress:(Q,m,p)=>t.progress(Q,m,`cutting ${p}`),throwIfCancelled:()=>t.throwIfCancelled()});if(t.progress(1,1,"done"),l.length===0)return t.note("None of the ticked sequences could be read from this reference."),[];const g=Ld(A,r),f=c?g:a.length<=3?`${g} on ${a.map(Q=>Q.name).join(", ")}`:`${g} on ${a.length.toLocaleString()} sequences`;let h=0,u=0;for(const Q of l)h+=Q.cuts.top.length,u+=Q.length;const I=h+l.length;t.note(h===0?`No ${g} site anywhere in ${c?"this reference":"the sequences ticked"}, so each sequence is one fragment.`:`${h.toLocaleString()} ${g} ${h===1?"cut":"cuts"} on ${l.length.toLocaleString()} ${l.length===1?"sequence":"sequences"}: ${I.toLocaleString()} fragments, ${Math.round(u/I).toLocaleString()} bp long on average.`);const d=`restriction-${xd(A,r)}${c?"":Ud(a)}`,C=vd(l,r),E=[Td(C,f,d)],B=Jd(t,C,f,d);return B!==null&&E.push(B),E};function Ud(t){const e=t.map(A=>A.name);if(e.length<=3)return`-on-${e.map(A=>A.replace(/[^A-Za-z0-9]/g,"")).join("-")}`;let n=5381;for(const A of e.join(`
-`))n=(n*33^A.charCodeAt(0))>>>0;return`-on${e.length}-${n.toString(36)}`}function vd(t,e){let n=0;for(const i of t)n+=i.cuts.top.length;const A=e.map(i=>i.name),s=e.map(i=>`${i.name} cuts ${Ia(i)}`),r={contigs:t.map(i=>i.contig),length:n,contig:new Int32Array(n),start:new Int32Array(n),end:new Int32Array(n),strand:new Int8Array(n),score:new Float32Array(n).fill(Number.NaN),name:new Array(n),id:new Array(n).fill(""),detail:new Array(n),exonAt:new Int32Array(n+1),exonStart:new Int32Array(0),exonEnd:new Int32Array(0),cdsStart:new Int32Array(n).fill(-1),cdsEnd:new Int32Array(n).fill(-1),contigAt:new Int32Array(t.length+1),maxSpan:new Int32Array(t.length)};let o=0;return t.forEach((i,a)=>{const{top:c,enzyme:l}=i.cuts;r.contigAt[a]=o,r.contig.fill(a,o,o+c.length),r.start.set(c,o);for(let g=0;g<c.length;g++)r.end[o+g]=c[g]+1,r.name[o+g]=A[l[g]],r.detail[o+g]=s[l[g]];c.length>0&&(r.maxSpan[a]=1),o+=c.length}),r.contigAt[t.length]=o,r}function Td(t,e,n){return{kind:"intervals",id:n,label:`${e} sites`,payload:{kind:"features",data:t},noun:{one:"site",many:"sites"},display:"lane",look:"point"}}function Jd(t,e,n,A){const s=t.framing.binsize,r=Kn(t);if(!(s>0)||r.length===0)return t.note("The sites are a lane; the density is not. A per-bin track needs the bin grid of an open contact map, and this session has none. Open the map and run it again for that half."),null;const o=e.contigs.map((a,c)=>{const l=e.contigAt[c],g=e.contigAt[c+1];return{contig:a,starts:e.start.subarray(l,g),ends:e.end.subarray(l,g),strands:e.strand.subarray(l,g)}}),i=Zi({hits:o,total:e.length},r,s);return{kind:"profile",id:`${A}-density`,label:`${n} site density`,values:i.values,extent:[0,i.values.length],binsize:s,unit:"sites"}}const $d=async t=>{const e=Yn(t.params,"tracks");if(e.length<2)return t.note(e.length===0?"No tracks were chosen. Load two or more bigWigs and tick them under Tracks.":"Only one track was chosen, and a correlation needs two."),[];const n=I=>t.inputs.labels?.[I]??I,A=e.map(n),s=await Yd(t);if(s.count===0)return t.note("No unit to compare over. Check that the tracks and the assembly share contig names."),[];const r=[];for(let I=0;I<e.length;I++)t.throwIfCancelled(),t.progress(I,e.length,A[I]),r.push(await _d(t,e[I],s));t.progress(e.length,e.length,"correlating");const o=Kd(r),i=s.kind==="bins"?"windows":"features";if(o<bn)t.note(`Fewer than ${bn} of the ${s.count.toLocaleString()} ${i} have a value in every track, so no pair has a coefficient. Check that the tracks cover the same sequences.`);else if(o<s.count){const I=s.count-o,d=I===1;t.note(`${I.toLocaleString()} of the ${s.count.toLocaleString()} ${i} ${d?"has":"have"} no value in at least one track, and ${d?"is":"are"} left out of every pair: every coefficient is over the other ${o.toLocaleString()}.`)}const a=st(t.params,"method","spearman"),c=e.length,l=new Float32Array(c*c),g=[];for(let I=0;I<c;I++){l[I*c+I]=1;for(let d=I+1;d<c;d++){const C=a==="pearson"?$i(r[I],r[d]):xh(r[I],r[d]);l[I*c+d]=C,l[d*c+I]=C,g.push({a:A[I],b:A[d],r:C})}}const f={kind:"matrix",id:"trackcorr",label:`Track correlation · ${a}`,nrows:c,ncols:c,values:l,xLabel:"",yLabel:"",xTicks:A,yTicks:A,colormap:bl,centre:0,stats:[{label:"units",value:s.count,digits:0},{label:"compared",value:o,digits:0,hint:"Units every track has a value for: the ones every pair is correlated over."}]},h={kind:"table",id:"trackcorr-table",label:"Pairs",columns:[{key:"a",label:"Track",kind:"text"},{key:"b",label:"Track",kind:"text"},{key:"r",label:a==="pearson"?"Pearson r":"Spearman ρ",kind:"number",digits:3}],rows:g.sort((I,d)=>Number(d.r)-Number(I.r))};return[f,h]};async function Yd(t){if(st(t.params,"over","bins")==="features"){const s=ne(t.inputs.features,t.params,"features"),r=s.value;if(r===void 0)return t.note(_n(s,{unchosen:"Correlating over features needs a feature set, and none was chosen.",gone:"The feature set chosen is no longer loaded. Re-open the file, or pick another."})??""),{kind:"features",regions:[],count:0};const o=[];for(let i=0;i<r.length;i++)o.push({contig:r.contigs[r.contig[i]],start:r.start[i],end:r.end[i]});return{kind:"features",regions:o,count:o.length}}const e=Math.max(1,Math.round(T(t.params,"binsize",100))),n=[];let A=0;for(const[s,r]of Object.entries(t.inputs.contigLengths??{})){const o=Math.floor(r/e);o!==0&&(n.push({contig:s,count:o,offset:A}),A+=o)}return{kind:"bins",size:e,tilings:n,count:A}}const Od=1<<20,co=4096;async function _d(t,e,n){const A=new Float64Array(n.count),s=new Float64Array(n.count),r=(o,i,a,c,l,g)=>{const f=Math.min(l,a)-Math.max(c,i);f>0&&(A[o]+=g*f,s[o]+=f)};if(n.kind==="bins"){const{size:o}=n,i=Math.max(1,Math.floor(Od/o))*o;for(const a of n.tilings){const c=a.count*o;for(let l=0;l<c;l+=i){t.throwIfCancelled();const g=Math.min(c,l+i),f=await t.sample(e,[{contig:a.contig,start:l,end:g}],1);for(const h of f.regions)for(let u=0;u<h.values.length;u++){const I=h.values[u];if(!Number.isFinite(I))continue;const d=Math.max(l,h.starts[u]),C=Math.min(g,h.ends[u]);for(let E=Math.floor(d/o);E*o<C;E++)r(a.offset+E,E*o,(E+1)*o,d,C,I)}}}}else{const o=new Map;n.regions.forEach((i,a)=>{const c=o.get(i.contig);c===void 0?o.set(i.contig,[a]):c.push(a)});for(const[,i]of o)for(let a=0;a<i.length;a+=co){t.throwIfCancelled();const c=i.slice(a,a+co),l=await t.sample(e,c.map(f=>n.regions[f]),1),g=new Map;for(const f of l.regions)g.set(`${f.contig}:${f.start}-${f.end}`,f);for(const f of c){const h=n.regions[f],u=g.get(`${h.contig}:${h.start}-${h.end}`);if(u!==void 0)for(let I=0;I<u.values.length;I++){const d=u.values[I];Number.isFinite(d)&&r(f,h.start,h.end,u.starts[I],u.ends[I],d)}}}}for(let o=0;o<A.length;o++)A[o]=s[o]>0?A[o]/s[o]:Number.NaN;return A}function Kd(t){const e=t.length===0?0:t[0].length;let n=0;for(let A=0;A<e;A++)if(t.every(s=>!Number.isNaN(s[A])))n++;else for(const s of t)s[A]=Number.NaN;return n}const qd={motif:Uu,restriction:Gd,peaks:ad,composition:Xu,dotplot:fI,oriter:yI,metaplot:Cu,trackcorr:$d,frip:vh,groupsignal:Zh,overlap:DI},Hd="0.18.0",Wd="b1f1a7a";function Pd(t){const e=[],n=new Set;for(const A of t.split(/\r?\n/)){const s=A.trim();if(s===""||s.startsWith("#"))continue;const r=s.split(/\s+/);if(r.length<5)return[];const[o,i,a,c,l]=[r[0],Number(r[1]),Number(r[2]),Number(r[3]),Number(r[4])];if([i,a,c,l].some(f=>!Number.isInteger(f)||f<0))return[];if(c===0||l<c)return[];n.has(o)||(n.add(o),e.push({name:o,length:i,offset:a,lineBases:c,lineWidth:l}))}return e}function zd(t){return t.map(e=>({name:e.name,length:e.length}))}function cn(t,e){const n=Math.floor(e/t.lineBases);return t.offset+n*t.lineWidth+(e-n*t.lineBases)}function Xd(t,e,n){const A=Math.max(0,Math.min(t.length,Math.floor(e))),s=Math.max(A,Math.min(t.length,Math.ceil(n)));return s<=A?{from:cn(t,A),to:cn(t,A)}:{from:cn(t,A),to:cn(t,s-1)+1}}function Vd(t){let e=0;for(let s=0;s<t.length;s++)t[s]>32&&e++;if(e===t.length)return t;const n=new Uint8Array(e);let A=0;for(let s=0;s<t.length;s++)t[s]>32&&(n[A++]=t[s]);return n}const Ca=/\.(fa|fasta|fna|fas)$/i;function Zd(t){if(/\.b?gz$/i.test(t))return`${t}.tbi`;if(/\.bam$/i.test(t))return`${t}.bai`;if(Ca.test(t))return`${t}.fai`}const JA=18,jd=4,tC=/\.(biginteract|interact)(\.b?gz)?$/i;function eC(t){return t!==void 0&&t!==""&&Number.isFinite(Number(t))}function lo(t){return t==="+"||t==="-"||t==="."||t===""}function Qa(t,e=""){const n=tC.test(e);let A=0,s=0;const r=t.length;for(;s<r&&A<jd;){let o=t.indexOf(`
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-`,n);s<0&&(s=A);let r=s;r>n&&t.charCodeAt(r-1)===13&&r--;const o=t.slice(n,r);if(n=s+1,o===""||o.charCodeAt(0)===35||o.startsWith("track ")||o.startsWith("browser "))continue;const i=o.includes("	")?o.split("	"):o.trim().split(/\s+/);if(Da(i)===null)return!1;e++}return e>0}function wC(t){if(t==="gneg")return 0;if(t.startsWith("gpos")){const e=t.slice(4);if(e==="")return 100;const n=Number(e);return Number.isFinite(n)?Math.max(0,Math.min(100,n)):100}return Number.NaN}function pC(t){const e=t.indexOf(`${$A} `);if(e<0)return"";const n=e+$A.length+1,A=t.indexOf(" ",n);return A<0?t.slice(n):t.slice(n,A)}function Fa(t){const e=new et;let n=0;if(wt(t,A=>{const s=Da(A);if(s===null){n++;return}e.add(A[0],Number(A[1]),Number(A[2]),{name:s.name,score:wC(s.stain),detail:`${$A} ${s.stain}`})}),e.length===0&&n>0)throw new Error(`No usable rows: all ${n} lines failed the "sequence, start, end, band, stain" test a cytoBand is made of.`);return e.finish()}function yC(t){const e=[];for(let n=0;n<t.contigs.length;n++){const A=t.contigAt[n],s=t.contigAt[n+1];if(s<=A)continue;let r=0;for(let o=A;o<s;o++){if(t.start[o]!==r)return null;r=t.end[o]}e.push({name:t.contigs[n],length:r})}return e.length>0?e:null}function Sa(t){let e=0,n=0;for(let r=0;r<t.length;r++)pC(t.detail[r])==="acen"&&e++,t.name[r]!==""&&n++;const A=t.contigAt.reduce((r,o,i)=>i<t.contigs.length&&t.contigAt[i+1]>t.contigAt[i]?r+1:r,0),s=[`${G.int(t.length)} band${t.length===1?"":"s"}`,`${G.int(A)} sequence${A===1?"":"s"}`];return n<t.length&&s.push(`${G.int(n)} named`),e>0&&s.push(`${G.int(e)} centromeric`),s.join(" · ")}const NC=["non-canonical","GT/AG","GT/AG","GC/AG","GC/AG","AT/AC","AT/AC"],kC="multi",bC="motif",YA="annotated",DC="overhang",MC="anchors",FC=8;function SC(t){const e=[];let n=!1,A=0;const s=t.length;for(;A<s&&e.length<FC;){let r=t.indexOf(`
-`,A);r<0&&(r=s);let o=r;o>A&&t.charCodeAt(o-1)===13&&o--;const i=t.slice(A,o);if(A=r+1,!(i===""||i.charCodeAt(0)===35)){if(i.startsWith("track ")){/junction/i.test(i)&&(n=!0);continue}i.startsWith("browser ")||e.push(i.includes("	")?i.split("	"):i.trim().split(/\s+/))}}return{rows:e,declared:n}}function Ra(t){if(t.length!==9)return!1;for(let s=1;s<9;s++)if(!S(t[s]))return!1;const e=Number(t[3]),n=Number(t[4]),A=Number(t[5]);return Number(t[2])>=Number(t[1])&&e>=0&&e<=2&&n>=0&&n<=6&&(A===0||A===1)}function La(t){if(t.length<12||!S(t[1])||!S(t[2])||t[9]!=="2")return null;const e=t[10].split(",").filter(a=>a!==""),n=t[11].split(",").filter(a=>a!=="");if(e.length!==2||n.length!==2||!e.every(S)||!n.every(S))return null;const A=Number(t[1]),s=Number(t[2]),r=Number(e[0]),o=Number(e[1]),i=Number(n[1]);return Number(n[0])!==0||A+i+o!==s||r<=0||o<=0||i<=r?null:[A+r,i-r,o]}function xa(t){return t.length===6&&S(t[1])&&S(t[2])&&S(t[4])&&(t[5]==="+"||t[5]==="-"||t[5]===".")}function Ds(t,e=""){const{rows:n,declared:A}=SC(t);if(n.length===0)return null;if(n.every(Ra))return"star";const s=/junc|(^|[._-])sj([._-]|$)/i.test(e.replace(/\.b?gz$/i,"")),r=n.every(o=>/^JUNC/i.test(o[3]??""));return(s||A||r)&&n.every(o=>La(o)!==null)?"bed":/\.junc(\.b?gz)?$/i.test(e)&&n.every(xa)?"junc":null}function ho(t){return t==="+"?1:t==="-"?-1:0}function RC(t){if(t===void 0||t===""||t===".")return Number.NaN;const e=Number(t);return Number.isFinite(e)?e:Number.NaN}function Ga(t,e="",n){const A=Ds(t,e);if(A===null)throw new Error("This is not a junction file STAR, regtools or leafcutter wrote.");const s=new et;let r=0;if(wt(t,o=>{if(A==="star"){if(!Ra(o)){r++;return}const i=Number(o[3]),a=Number(o[4]),c=[`${kC} ${o[7]}`,`${bC} ${NC[a]}`,`${YA} ${o[5]==="1"?"yes":"no"}`,`${DC} ${o[8]}`].join(ct);s.add(o[0],Number(o[1])-1,Number(o[2]),{strand:i===1?1:i===2?-1:0,score:Number(o[6]),detail:c});return}if(A==="bed"){const i=La(o);if(i===null){r++;return}const[a,c,l]=i,g=a-Number(o[1]),f=o[3]!==void 0&&o[3]!=="."?o[3]:"";s.add(o[0],a,a+c,{strand:ho(o[5]),score:RC(o[4]),name:f,detail:`${MC} ${g}/${l}`});return}if(!xa(o)){r++;return}s.add(o[0],Number(o[1]),Number(o[2]),{strand:ho(o[5]),score:Number(o[4]),name:o[3]!=="."?o[3]:""})}),s.length===0&&r>0)throw new Error(`No usable rows: all ${r} lines failed the junction test for this file's shape.`);return s.finish()}function Ua(t){let e=0,n=0,A=!1;for(let r=0;r<t.length;r++){const o=t.score[r];Number.isFinite(o)&&(e+=o);const i=t.detail[r];i.includes(`${YA} `)&&(A=!0,i.includes(`${YA} yes`)&&n++)}const s=[`${G.int(t.length)} junction${t.length===1?"":"s"}`,`${G.int(e)} read${e===1?"":"s"}`];return A&&s.push(`${G.int(n)} annotated`),s.join(ct)}const OA=11,xn=9,_A=10,LC=4,xC=/\.(bedmethyl|bigmethyl|bed ?methyl)(\.b?gz)?$/i;function va(t,e=""){const n=xC.test(e);let A=0,s=0;const r=t.length;for(;s<r&&A<LC;){let o=t.indexOf(`
-`,s);o<0&&(o=r);let i=o;i>s&&t.charCodeAt(i-1)===13&&i--;const a=t.slice(s,i);if(s=o+1,a===""||a.charCodeAt(0)===35||a.startsWith("track ")||a.startsWith("browser "))continue;const c=a.includes("	")?a.split("	"):a.trim().split(/\s+/);if(!GC(c,n))return!1;A++}return A>0}function GC(t,e){if(t.length<OA||!S(t[1])||!S(t[2]))return!1;const n=Number(t[_A]);if(t[_A]===""||!Number.isFinite(n))return!1;if(e)return!0;if(!S(t[xn])||Number(t[xn])<0||n<0||n>100)return!1;const A=t[5];return A!=="+"&&A!=="-"&&A!=="."?!1:Number(t[2])-Number(t[1])===1}function Ta(t){const e=new Map;Io(t,c=>{if(c.length<OA||!S(c[1])||!S(c[2]))return;const l=uo(c[3]);e.set(l,(e.get(l)??0)+1)});const n=[...e.entries()].map(([c,l])=>({code:c,label:Pl(c),rows:l})).sort((c,l)=>l.rows-c.rows||c.code.localeCompare(l.code));if(n.length===0)throw new Error("This looks like a bedMethyl but holds no usable rows.");const A=n[0].code,s=new Map;let r=Number.POSITIVE_INFINITY,o=Number.NEGATIVE_INFINITY,i=0,a=0;if(Io(t,c=>{if(c.length<OA||!S(c[1])||!S(c[2])||uo(c[3])!==A)return;const l=Number(c[1]),g=Number(c[2]);if(g<=l)return;const f=Number(c[_A]);if(!Number.isFinite(f))return;const h=S(c[xn])?Number(c[xn]):0;if(h<=0)return;const u=c[0]??"";let I=s.get(u);I===void 0&&(I=new Cs(u),s.set(u,I)),I.push(l,g,f),i++,a+=h,f<r&&(r=f),f>o&&(o=f)}),i===0)throw new Error("This looks like a bedMethyl but every row rests on zero reads, so there is no measurement to draw.");return{signal:Qs(s,i,r,o),codes:n,drawn:A,meanCoverage:a/i}}function uo(t){return t===void 0||t===""||t==="."?"?":t}function Io(t,e){for(const n of t.split(`
-`)){let A=n;A.endsWith("\r")&&(A=A.slice(0,-1)),!(A===""||A.charCodeAt(0)===35)&&(A.startsWith("track ")||A.startsWith("browser ")||e(A.includes("	")?A.split("	"):A.trim().split(/\s+/)))}}function UC(t){return/\b(percentMod|percentMeth|fractionModified)\b/.test(t)&&/\b(validCov|coverage|Nvalid_cov)\b/.test(t)}function vC(t){const e=t.codes.find(s=>s.code===t.drawn),n=[`${t.signal.length.toLocaleString()} ${e?.label??t.drawn} calls`,`${t.meanCoverage.toFixed(1)}× mean depth`],A=t.codes.filter(s=>s.code!==t.drawn);return A.length>0&&n.push(`not drawn: ${A.map(s=>`${s.label} (${s.rows.toLocaleString()})`).join(", ")}`),n.join(" · ")}const Gn=440477507,Un=".2bit",Ja=16,TC=new Uint8Array([84,67,65,71]),JC=78;function $a(t){if(t.length<4)return!1;const e=new DataView(t.buffer,t.byteOffset,4);return e.getUint32(0,!0)===Gn||e.getUint32(0,!1)===Gn}function $C(t){if(t.length<Ja)throw new Error("This file starts like a .2bit and is too short to hold one.");const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=e.getUint32(0,!0)===Gn;if(!n&&e.getUint32(0,!1)!==Gn)throw new Error("This is not a .2bit: its first four bytes are not the format’s signature.");const A=e.getUint32(4,n);if(A!==0)throw new Error(`This is a .2bit of version ${A}. This viewer reads version 0 — the ordinary one, with 32-bit offsets. Version 1 is the “long” variant for files past 4 GB, whose offsets and sizes are 64-bit, and reading one as though it were version 0 would return wrong residues rather than fail. Convert it with \`twoBitToFa\` and \`faToTwoBit\`.`);const s=e.getUint32(8,n);if(s===0)throw new Error("This .2bit declares no sequences.");return{littleEndian:n,version:A,count:s}}function Co(t,e,n=Ja){const A=new DataView(t.buffer,t.byteOffset,t.byteLength),s=[];let r=n;const o=new TextDecoder;for(;s.length<e.count&&!(r+1>t.length);){const i=t[r];if(r+1+i+4>t.length)break;const a=o.decode(t.subarray(r+1,r+1+i)),c=A.getUint32(r+1+i,e.littleEndian);s.push({name:a,offset:c}),r+=1+i+4}return{entries:s,complete:s.length===e.count,consumed:r}}function Qo(t,e,n,A={}){if(e+8>t.length)return 8;const s=new DataView(t.buffer,t.byteOffset,t.byteLength),r=Ya(s,e,n,A),o=e+8+r*8;return o+4>t.length?o+4-e:null}function Ya(t,e,n,A){return nt(t.getUint32(e+4,n),{format:Un,field:`N-block count${A.name===void 0?"":` of ${A.name}`}`,ceiling:t.getUint32(e,n),...A.fileLeft===void 0?{}:{available:A.fileLeft-8-4},bytesPerItem:8})}function YC(t,e,n,A,s=0,r){const o=new DataView(e.buffer,e.byteOffset,e.byteLength),i=o.getUint32(n,A),a=Ya(o,n,A,{name:t,fileLeft:e.length-n}),c=new Int32Array(a),l=new Int32Array(a),g=n+8,f=g+a*4;for(let d=0;d<a;d++){const C=o.getUint32(g+d*4,A);c[d]=C,l[d]=C+o.getUint32(f+d*4,A)}const h=f+a*4,u=nt(o.getUint32(h,A),{format:Un,field:`mask-block count of ${t}`,ceiling:i,...r===void 0?{}:{available:r-(s+h+4)-4},bytesPerItem:8}),I=s+h+4+u*8+4;return r!==void 0&&ss(I,Math.ceil(i/4),{format:Un,field:`packed bases of ${t}`,size:r}),{name:t,length:i,nStarts:c,nEnds:l,dnaAt:I}}const OC=8192;function _C(t,e,n){const A=Math.max(0,Math.min(e,t.length)),s=Math.max(A,Math.min(n,t.length)),r=Math.floor(A/4),o=Math.ceil(s/4);return{from:t.dnaAt+r,to:t.dnaAt+o,firstBase:r*4}}function KC(t,e,n,A,s){const r=Math.max(0,Math.min(A,n.length)),o=Math.max(r,Math.min(s,n.length)),i=new Uint8Array(o-r);for(let a=r;a<o;a++){const c=a-e,l=t[c>>2];if(l===void 0)break;const g=6-((c&3)<<1);i[a-r]=TC[l>>g&3]}for(let a=0;a<n.nStarts.length;a++){const c=n.nStarts[a];if(c>=o)break;const l=n.nEnds[a];l<=r||i.fill(JC,Math.max(r,c)-r,Math.min(o,l)-r)}return i}function qC(t){return t.map(e=>({name:e.name,length:e.length}))}const Bo=65536,Eo=1e5;async function HC(t,e){let n=await t(Bo,0);const A=$C(n);if(A.count>Eo)throw new Error(`This .2bit declares ${A.count.toLocaleString()} sequences, which is past the ${Eo.toLocaleString()} this viewer will open one record at a time. A file that says this is far more likely to be truncated than to be an assembly.`);let s=Co(n,A);for(;!s.complete;){const a=await t(Bo,n.length);if(a.length===0)throw new Error(`This .2bit ends part-way through its index: it declares ${A.count.toLocaleString()} sequences and names ${s.entries.length.toLocaleString()}. The file is truncated.`);const c=new Uint8Array(n.length+a.length);c.set(n),c.set(a,n.length),n=c,s=Co(n,A)}const r=new Map,o=[];let i=0;for(const a of s.entries){e!==void 0&&ss(a.offset,8,{format:Un,field:`index entry for ${a.name}`,size:e});const c={name:a.name,...e===void 0?{}:{fileLeft:e-a.offset}};let l=await t(OC,a.offset),g=Qo(l,0,A.littleEndian,c);for(;g!==null;){const h=await t(g,a.offset);if(h.length<=l.length)throw new Error(`This .2bit ends part-way through the record for ${a.name}.`);l=h,g=Qo(l,0,A.littleEndian,c)}const f=YC(a.name,l,0,A.littleEndian,a.offset,e);r.set(f.name,f),o.push(f),i+=f.length}return{ordered:o,records:r,total:i}}const WC=2291137574,PC=2273964779,mo=[137,72,68,70,13,10,26,10];function zC(t){return t.length<mo.length?!1:mo.every((e,n)=>t[n]===e)}function Oa(t){if(t.length<4)return null;const e=new DataView(t.buffer,t.byteOffset,4);for(const n of[!0,!1]){const A=e.getUint32(0,n);if(A===WC)return"bigwig";if(A===PC)return"bigbed"}return null}function ft(t,e){const n=pe(rl(t),e);for(let A=0;A<n.names.length;A++)t[A]=n.names[A];return n}function Z(t,e,n){const A=El(t,qa(e)),s=XC(t,e),r=n?.contested??[];return{...A,...s===null?{}:{genomes:s},...r.length===0?{}:{contested:r.slice(0,4).map(o=>`${o.asked} → ${o.name}`)}}}function XC(t,e){const n=new Set;for(const r of e)r.genome!==void 0&&r.genome!==""&&n.add(r.genome);if(n.size===0)return null;const A=new Set(t),s=new Set;for(const r of e)r.genome===void 0||r.genome===""||A.has(r.name)&&s.add(r.genome);return{matched:s.size,total:n.size,named:[...s].slice(0,4)}}function qn(t,e){const n=t.bases.get(e);if(n!==void 0)return n;const A=Kt(t.contigs,e);return A<0?void 0:t.bases.get(t.contigs[A].name)}function Ms(t,e){const n=t.records.get(e);if(n!==void 0)return n;const A=Kt(t.contigs,e);return A<0?void 0:t.records.get(t.contigs[A].name)}async function _a(t,e,n,A,s){const r=Ms(t,e);if(r===void 0)return;const o=Math.max(0,Math.floor(n)),i=Math.min(r.length,Math.ceil(A));if(!(i>o))return new Uint8Array(0);const a=t.held.get(r.name);if(a!==void 0&&a.start<=o&&a.start+a.bases.length>=i)return a.bases.subarray(o-a.start,i-a.start);const c=await Ka(t,r,o,i,s);return t.held.set(r.name,{start:o,bases:c}),c}async function Ka(t,e,n,A,s){const r=s===void 0?{}:{onProgress:s};if(_t(t)){const i=e,a=_C(i,n,A),c=await t.handle.read(a.to-a.from,a.from,r);return KC(c,a.firstBase,i,n,A)}const o=Xd(e,n,A);return Vd(await t.handle.read(o.to-o.from,o.from,r))}function qa(t){return t.map(e=>e.name)}const Fs=new Map,Hn=new Map;function Ss(t){return t.indexed===!0}function _t(t){return t.twobit===!0}function we(t){return Ss(t)||_t(t)}const re=new Map,KA=new Map,Wn=new Map,vn=new Map;function VC(t,e){return`${tt(t)}|${tt(e)}`}const wo=8<<20,Rs=3e8,qA=64e6,po=4e6;let Mt=null,oe=null;function tt(t){return t.kind==="local"?`${t.name}|${t.file.size}`:t.url}self.onmessage=t=>{jC(t.data)};const ZC=Nh();setInterval(()=>{const t={type:"busy",fraction:ZC.busy()};self.postMessage(t)},yh);const Pn=new Set,HA=new Set;let WA=0;function PA(t){return Pn.has(t)}async function Ls(t){return await Bs(),!Pn.has(t)}function ze(){const t=new Error("cancelled");return t.name="AbortError",t}async function jC(t){HA.add(t.id);try{const e=await tQ(t);if(PA(t.id))throw ze();const n={type:"result",id:t.id,payload:e};self.postMessage(n,Eh(e))}catch(e){const n={type:"error",id:t.id,message:e instanceof Error?e.message:String(e),...e instanceof Error&&e.name==="AbortError"?{cancelled:!0}:{}};self.postMessage(n)}finally{HA.delete(t.id),Pn.delete(t.id),t.id>WA&&(WA=t.id)}}function Qn(t){return(e,n)=>{const A={type:"progress",id:t,done:e,total:n??0};self.postMessage(A)}}async function tQ(t){switch(t.kind){case"load":return aQ(t.entry,t.source,t.mapContigs,Qn(t.id));case"sample":return ja(t.entry,t.regions,t.basesPerPixel,t.reads,t.id,t.exact===!0);case"register":return KA.set(t.entry,t.vector),null;case"run":return eQ(t);case"bases":return EQ(t.entry,t.regions,Qn(t.id));case"assembly":return nQ(t.source,Qn(t.id));case"reads":return vQ(t.entry,t.regions,t.maxRows,t.basesPerPixel,t.reads,t.id);case"cancel":return(HA.has(t.target)||t.target>WA)&&Pn.add(t.target),null;case"drop":{Fs.delete(t.entry);const e=re.get(t.entry);e!==void 0&&oe?.store===e&&(oe=null),re.delete(t.entry),KA.delete(t.entry),Hn.delete(t.entry),Wn.delete(t.entry);for(const[n,A]of vn)if(A.holders.delete(t.entry)){A.holders.size===0&&vn.delete(n);break}return null}}}async function eQ(t){const e=qd[t.task];if(e===void 0)throw new Error(`no track analysis runner is registered for the task ${t.task}`);const n=[],A=performance.now(),s={params:t.params,framing:t.framing,inputs:t.inputs,cancelled:()=>PA(t.id),throwIfCancelled:()=>{if(PA(t.id))throw ze()},progress:(o,i,a)=>{const c={type:"progress",id:t.id,done:o,total:i,...a===void 0?{}:{note:a}};self.postMessage(c)},note:o=>{n.push(o)},sample:(o,i,a)=>ja(o,i,a,void 0,t.id),lengthOf:o=>t.inputs.contigLengths?.[o],residues:o=>{const i=re.get(o);if(i!==void 0)return we(i)?{contigs:i.contigs,bases:()=>{},read:async(a,c,l)=>{const g=Ms(i,a);if(g===void 0)return;const f=Math.max(0,Math.floor(c)),h=Math.min(g.length,Math.ceil(l));return h>f?Ka(i,g,f,h):new Uint8Array(0)},refusal:_t(i)?`This .2bit is read by range rather than held, so its sequences are not here whole to read. A FASTA under ${G.int(qA/1e6)} MB is held whole (\`twoBitToFa\`).`:`This FASTA is read by range from its index rather than held, so its sequences are not here whole to read. A FASTA under ${G.int(qA/1e6)} MB is held whole.`}:{contigs:i.contigs,bases:a=>qn(i,a)}}};return{outputs:await e(s),provenance:{task:t.task,taskVersion:0,params:t.params,framing:t.framing,app:[Hd,Wd].filter(o=>o!=="").join(" "),createdAt:new Date().toISOString()},notes:n,ms:performance.now()-A}}async function nQ(t,e){const n=xt(t),A=await n.read(64,0);if(zC(A))return{format:"hdf5",contigs:[],origin:"features",exact:!0};const s=Oa(A);if(s!==null){const h=await(s==="bigwig"?new To({filehandle:xt(t)}):new $o({filehandle:xt(t)})).getHeader();return{format:s,contigs:xs(h),origin:s,exact:!0}}if(We(A)){const f=await ke(n,t),h=await tc(n,f??Number.MAX_SAFE_INTEGER);if(h!==null)return{format:"bam",contigs:h.refs.map(u=>({name:u.name,length:u.length})),origin:"bam",exact:!0}}if(kn(A))return{format:"fasta",contigs:(await Xa(t,n,e)).contigs,origin:"fasta",exact:!0};if($a(A))return{format:"twobit",contigs:(await Va(t,n,e)).contigs,origin:"twobit",exact:!0};const r=await 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Float32Array(0)};const A=4,s=A+n*4,r=s+n*4;return{starts:new Int32Array(t.buffer,t.byteOffset+A,n),ends:new Int32Array(t.buffer,t.byteOffset+s,n),scores:new Float32Array(t.buffer,t.byteOffset+r,n)}}function Rc(t){const n=new DataView(t.buffer,t.byteOffset,t.byteLength).getUint32(0,!0);if(n===0)return{starts:new Int32Array(0),ends:new Int32Array(0),scores:new Float32Array(0),minScores:new Float32Array(0),maxScores:new Float32Array(0)};const A=4,s=A+n*4,r=s+n*4,o=r+n*4,i=o+n*4;return{starts:new Int32Array(t.buffer,t.byteOffset+A,n),ends:new Int32Array(t.buffer,t.byteOffset+s,n),scores:new Float32Array(t.buffer,t.byteOffset+r,n),minScores:new Float32Array(t.buffer,t.byteOffset+o,n),maxScores:new Float32Array(t.buffer,t.byteOffset+i,n)}}async function Lc(t,e,n,A,s,r){await es();const o=Ro(t,e,n,A,s,r);return Sc(o)}async function Gc(t,e,n,A,s,r,o){await es();const i=Lo(t,e,n,A,s,r,o);return Rc(i)}function ns(t){const e=new Uint32Array(t.length),n=new Uint32Array(t.length);for(let A=0;A<t.length;A++){const s=t[A];e[A]=s.offset,n[A]=s.length}return{inputOffsets:e,inputLengths:n}}async function xc(t,e,n){const{inputOffsets:A,inputLengths:s}=ns(e);return Fc(t,A,s,n)}async function vc(t,e,n,A,s){const{inputOffsets:r,inputLengths:o}=ns(e);return Lc(t,r,o,n,A,s)}async function Uc(t,e,n,A,s,r){const{inputOffsets:o,inputLengths:i}=ns(e);return Gc(t,o,i,n,A,s,r)}const As=new TextDecoder("utf8");function rt(t,e=0){return new DataView(t.buffer,t.byteOffset+e,t.length-e)}function j(t,e){return t.getUint32(e,!0)+t.getUint32(e+4,!0)*2**32}function CA(t,e,n){const A=t.indexOf(0,e),s=A!==-1&&A<e+n?A:e+n;return As.decode(t.subarray(e,s))}function Tc(t){const e=t.toSorted((s,r)=>s.offset-r.offset),n=[];let A;for(const s of e)A&&s.offset-(A.offset+A.length)<=2e3?(A.length=Math.max(A.length,s.offset+s.length-A.offset),A.blocks.push(s)):(A={blocks:[s],length:s.length,offset:s.offset},n.push(A));return n}const _s=610839776;function $c(t,e){let n=0;for(const s of t)n+=s.length;let A=0;return e?.(0,n),s=>{A+=s,e?.(A,n)}}function Ie(t,e,n,A){return t<A&&e>n}function xo(t,e){return e?t/e:t}function Jc(t,e){const n=[];let A=0;const s=rt(t);for(;A<t.byteLength;){const r=s.getUint32(A,!0);A+=4;const o=s.getUint32(A,!0);A+=4;const i=s.getUint32(A,!0);A+=4;const a=s.getUint32(A,!0);A+=4;const c=s.getFloat32(A,!0);A+=4;const l=s.getFloat32(A,!0);A+=4;const g=s.getFloat32(A,!0);A+=8,(!e||r===e.chrId&&Ie(o,i,e.start,e.end))&&n.push({start:o,end:i,maxScore:l,minScore:c,summary:!0,score:xo(g,a)})}return n}function Oc(t,e,n){const A=[];let s=0;const r=rt(t);for(;s<t.byteLength;){const o=s,i=r.getUint32(s,!0);s+=4;const a=r.getInt32(s,!0);s+=4;const c=r.getInt32(s,!0);s+=4;const l=t.indexOf(0,s),g=l===-1?t.length:l,f=As.decode(t.subarray(s,g));s=g+1,(!n||i===n.chrId&&Ie(a,c,n.start,n.end))&&A.push({start:a,end:c,rest:f,uniqueId:`bb-${e}-${o}`})}return A}function Yc(t,e){const n=rt(t),A=n.getInt32(4,!0),s=n.getUint32(12,!0),r=n.getUint32(16,!0),o=n.getUint8(20),i=n.getUint16(22,!0);let a=24;const c=[];switch(o){case 1:{for(let l=0;l<i;l++){const g=n.getInt32(a,!0);a+=4;const f=n.getInt32(a,!0);a+=4;const h=n.getFloat32(a,!0);a+=4,(!e||Ie(g,f,e.start,e.end))&&c.push({start:g,end:f,score:h})}break}case 2:{for(let l=0;l<i;l++){const g=n.getInt32(a,!0);a+=4;const f=n.getFloat32(a,!0);a+=4;const h=g+r;(!e||Ie(g,h,e.start,e.end))&&c.push({score:f,start:g,end:h})}break}case 3:{for(let l=0;l<i;l++){const g=n.getFloat32(a,!0);a+=4;const f=A+l*s,h=f+r;(!e||Ie(f,h,e.start,e.end))&&c.push({score:g,start:f,end:h})}break}}return c}function Ks(t,e){const n=rt(t),A=n.getInt32(4,!0),s=n.getUint32(12,!0),r=n.getUint32(16,!0),o=n.getUint8(20),i=n.getUint16(22,!0),a=new Int32Array(i),c=new Int32Array(i),l=new Float32Array(i),g=e.start,f=e.end;let h=0;switch(o){case 1:{let u=24;for(let I=0;I<i;I++){const d=n.getInt32(u,!0),C=n.getInt32(u+4,!0);d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u+8,!0),h++),u+=12}break}case 2:{let u=24;for(let I=0;I<i;I++){const d=n.getInt32(u,!0),C=d+r;d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u+4,!0),h++),u+=8}break}case 3:{let u=24;for(let I=0;I<i;I++){const d=A+I*s,C=d+r;d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u,!0),h++),u+=4}break}}return h<i?{starts:a.subarray(0,h),ends:c.subarray(0,h),scores:l.subarray(0,h)}:{starts:a,ends:c,scores:l}}function qs(t,e){const n=rt(t),A=Math.floor(t.byteLength/32),s=new Int32Array(A),r=new Int32Array(A),o=new Float32Array(A),i=new Float32Array(A),a=new Float32Array(A);let c=0,l=0;for(;l<t.byteLength;){const g=n.getUint32(l,!0);l+=4;const f=n.getUint32(l,!0);l+=4;const h=n.getUint32(l,!0);l+=4;const u=n.getUint32(l,!0);l+=4;const I=n.getFloat32(l,!0);l+=4;const d=n.getFloat32(l,!0);l+=4;const C=n.getFloat32(l,!0);l+=8,g===e.chrId&&Ie(f,h,e.start,e.end)&&(s[c]=f,r[c]=h,o[c]=xo(C,u),i[c]=I,a[c]=d,c++)}return c<A?{starts:s.subarray(0,c),ends:r.subarray(0,c),scores:o.subarray(0,c),minScores:i.subarray(0,c),maxScores:a.subarray(0,c)}:{starts:s,ends:r,scores:o,minScores:i,maxScores:a}}function Ue(t,e,n,A){if(t.length===1)return e(t[0]);const s=new A(n);let r=0;for(const o of t){const i=e(o);s.set(i,r),r+=i.length}return s}function vo(t){let e=0;for(const n of t)e+=n.starts.length;return e}function Uo(t){const e=vo(t);return{starts:Ue(t,n=>n.starts,e,Int32Array),ends:Ue(t,n=>n.ends,e,Int32Array),scores:Ue(t,n=>n.scores,e,Float32Array),isSummary:!1}}function _c(t){const e=vo(t),{starts:n,ends:A,scores:s}=Uo(t);return{starts:n,ends:A,scores:s,minScores:Ue(t,r=>r.minScores,e,Float32Array),maxScores:Ue(t,r=>r.maxScores,e,Float32Array),isSummary:!0}}function To(t){let e=0;for(const i of t)for(const a of i)e+=a.starts.length;const n=new Int32Array(e),A=new Int32Array(e),s=new Float32Array(e),r=[0];let o=0;for(const i of t){for(const a of i)n.set(a.starts,o),A.set(a.ends,o),s.set(a.scores,o),o+=a.starts.length;r.push(o)}return{starts:n,ends:A,scores:s,regionOffsets:r,totalCount:e}}function Kc(t){const{starts:e,ends:n,scores:A,regionOffsets:s}=To(t);return{starts:e,ends:n,scores:A,regionOffsets:s,isSummary:!1}}function qc(t){const{starts:e,ends:n,scores:A,regionOffsets:s,totalCount:r}=To(t),o=new Float32Array(r),i=new Float32Array(r);let a=0;for(const c of t)for(const l of c)o.set(l.minScores,a),i.set(l.maxScores,a),a+=l.starts.length;return{starts:e,ends:n,scores:A,minScores:o,maxScores:i,regionOffsets:s,isSummary:!0}}function Hs(t,e,n,A){switch(t){case"summary":return Jc(e,A);case"bigwig":return Yc(e,A);case"bigbed":return Oc(e,n,A)}}class Hc{rTreePromise;rTreeNodeCache=new Bn({cache:new dc({maxSize:1e3}),fill:async({length:e,offset:n},A)=>this.bbi.read(e,n,{signal:A})});bbi;refsByName;rTreeOffset;uncompressBufSize;blockType;constructor(e,n,A,s,r){if(!(A>=0))throw new Error("invalid rTreeOffset!");this.bbi=e,this.refsByName=n,this.rTreeOffset=A,this.uncompressBufSize=s,this.blockType=r}async _collectBlocks(e,n,A,s){const r=this.refsByName[e];if(r===void 0||n>=A)return;this.rTreePromise||(this.rTreePromise=this.bbi.read(48,this.rTreeOffset,{signal:s?.signal}).catch(u=>{throw this.rTreePromise=void 0,u}));const o=await this.rTreePromise,i=rt(o),a=i.getUint32(0,!0);if(a!==_s)throw new Error(`invalid cirTree magic: 0x${a.toString(16)} (expected 0x${_s.toString(16)}) at offset ${this.rTreeOffset}, file may be corrupt or unsupported`);const l=4+i.getUint32(4,!0)*32,g=(u,I,d,C)=>(u<r||u===r&&I<A)&&(d>r||d===r&&C>n),f=[];let h=[this.rTreeOffset+48];for(;h.length>0;){const u=Cc(h.map(d=>({min:d,max:d+l}))),I=[];for(const{min:d,max:C}of u){const B=C-d,Q=d,E=await this.rTreeNodeCache.get(`${B}_${Q}`,{length:B,offset:Q},s?.signal);for(const m of h)if(d<=m&&m<=C){const p=E.subarray(m-Q),w=rt(p),y=w.getUint8(0),N=w.getUint16(2,!0);if(y===1||y===0){const k=y===1?32:24;let b=4;for(let M=0;M<N;M++){const F=w.getUint32(b,!0),S=w.getUint32(b+4,!0),v=w.getUint32(b+8,!0),G=w.getUint32(b+12,!0);if(g(F,S,v,G)){const O=j(w,b+16);if(y===1){const $=j(w,b+24);f.push({offset:O,length:$})}else I.push(O)}b+=k}}}}h=I}return{blocks:f,chrId:r}}async readWigData(e,n,A,s){const r=await this._collectBlocks(e,n,A,s);if(!r)return[];const{blocks:o,chrId:i}=r;return this.readFeatures(o,{...s,request:{chrId:i,start:n,end:A}})}async getBlockSizeForRange(e,n,A,s){const r=await this._collectBlocks(e,n,A,s);let o=0;if(r)for(const i of r.blocks)o+=i.length;return o}async getBlockSizeForRangeMulti(e,n={}){const{blockByOffset:A}=await this._collectBlocksMulti(e,n);let s=0;for(const r of A.values())s+=r.length;return s}async _collectBlocksMulti(e,n){const A=await Promise.all(e.map(({refName:o,start:i,end:a})=>this._collectBlocks(o,i,a,n))),s=new Map,r=new Map;for(let o=0;o<A.length;o++){const i=A[o];if(i){const{start:a,end:c}=e[o],l={chrId:i.chrId,start:a,end:c};for(const g of i.blocks){const f=r.get(g.offset);f?f.push({regionIndex:o,request:l}):(s.set(g.offset,g),r.set(g.offset,[{regionIndex:o,request:l}]))}}}return{blockByOffset:s,tagsByOffset:r}}async readWigDataMulti(e,n={}){const A=e.map(()=>[]),{blockByOffset:s,tagsByOffset:r}=await this._collectBlocksMulti(e,n),{blockType:o}=this;return await this._forEachDecodedBlock([...s.values()],n.signal,n.onProgress,(i,a)=>{const c=r.get(a);if(c)for(const{regionIndex:l,request:g}of c){const f=Hs(o,i,a,g);for(const h of f)A[l].push(h)}}),A}assertNotBigBed(e){if(this.blockType==="bigbed")throw new Error(`${e} is not supported for BigBed data; use getFeatures/getFeaturesMulti instead`)}async readWigDataAsArrays(e,n,A,s){this.assertNotBigBed("getFeaturesAsArrays");const r=await this._collectBlocks(e,n,A,s),o=r?r.blocks:[],i={chrId:r?r.chrId:0,start:n,end:A};return this.blockType==="summary"?this._readSummaryFeaturesAsArrays(o,i,s):this._readBigWigFeaturesAsArrays(o,i,s)}async readWigDataAsArraysMulti(e,n={}){this.assertNotBigBed("getFeaturesAsArraysMulti");const A=await this._collectBlocksMulti(e,n);return this.blockType==="summary"?qc(await this._readBlocksAsArraysMulti(A,e.length,(s,r)=>qs(s,r),n)):Kc(await this._readBlocksAsArraysMulti(A,e.length,(s,r)=>Ks(s,r),n))}async _readBlocksAsArraysMulti(e,n,A,s){const{blockByOffset:r,tagsByOffset:o}=e,i=Array.from({length:n},()=>[]);return await this._forEachDecodedBlock([...r.values()],s.signal,s.onProgress,(a,c)=>{const l=o.get(c);if(l)for(const{regionIndex:g,request:f}of l){const h=A(a,f);h.starts.length>0&&i[g].push(h)}}),i}async _forEachBlockGroup(e,n,A,s){const r=Tc(e),o=$c(r,A);for(const i of r){const a=await this.bbi.read(i.length,i.offset,{signal:n});o(i.length),await s(a,i.blocks.map(c=>({offset:c.offset-i.offset,length:c.length})),i.offset)}}async _forEachDecodedBlock(e,n,A,s){const{uncompressBufSize:r}=this;await this._forEachBlockGroup(e,n,A,async(o,i,a)=>{if(r>0){const{data:c,offsets:l}=await xc(o,i,r);for(let g=0;g<i.length;g++)s(c.subarray(l[g],l[g+1]),a+i[g].offset)}else for(const c of i)s(o.subarray(c.offset,c.offset+c.length),a+c.offset)})}async readFeatures(e,n={}){const{blockType:A}=this,{signal:s,request:r,onProgress:o}=n,i=[];return await this._forEachDecodedBlock(e,s,o,(a,c)=>{const l=Hs(A,a,c,r);for(const g of l)i.push(g)}),i}async _readBlocksAsArrays(e,n,A,s,r){const{uncompressBufSize:o}=this,i=[],a=c=>{c.starts.length>0&&i.push(c)};return await this._forEachBlockGroup(e,n,r,async(c,l)=>{if(o>0)a(await A(c,l));else for(const g of l)a(s(c.subarray(g.offset,g.offset+g.length)))}),i}async _readBigWigFeaturesAsArrays(e,n,A={}){const s=await this._readBlocksAsArrays(e,A.signal,(r,o)=>vc(r,o,this.uncompressBufSize,n.start,n.end),r=>Ks(r,n),A.onProgress);return Uo(s)}async _readSummaryFeaturesAsArrays(e,n,A={}){const s=await this._readBlocksAsArrays(e,A.signal,(r,o)=>Uc(r,o,this.uncompressBufSize,n.chrId,n.start,n.end),r=>qs(r,n),A.onProgress);return _c(s)}}const Wc=-2003829722,Ws=-2021002517;class $o{bbi;headerP;getHeader(e){return this.headerP||(this.headerP=this._getHeader(e).catch(n=>{throw this.headerP=void 0,n})),this.headerP}constructor(e){const{filehandle:n,path:A,url:s}=e;if(n)this.bbi=n;else if(s)this.bbi=new Fo(s);else if(A)this.bbi=new fc(A);else throw new Error("no file given")}async _getHeader(e){const n=await this._getMainHeader(e),A=await this._readChromosomeTree(n,e);return{...n,...A}}async _getMainHeader(e,n=2e3){const A=await this.bbi.read(n,0,e),s=rt(A);let r=0;const o=s.getInt32(r,!0);if(r+=4,o!==Wc&&o!==Ws)throw new Error("not a BigWig/BigBed file");const i=s.getUint16(r,!0);r+=2;const a=s.getUint16(r,!0);r+=2;const c=j(s,r);r+=8;const l=j(s,r);r+=8;const g=j(s,r);r+=8;const f=s.getUint16(r,!0);r+=2;const h=s.getUint16(r,!0);r+=2;const u=j(s,r);r+=8;const I=j(s,r);r+=8;const d=s.getUint32(r,!0);r+=4;const C=j(s,r);r+=8;const B=[];for(let y=0;y<a;y++){const N=s.getUint32(r,!0);r+=4,r+=4;const k=j(s,r);r+=8;const b=j(s,r);r+=8,B.push({reductionLevel:N,dataOffset:k,indexOffset:b})}const Q=o===Ws?"bigbed":"bigwig",E=A.length<n,m=u!==0&&!A.includes(0,u);if(!E&&(u>n||I>n-40||m))return this._getMainHeader(e,n*2);let p;if(I){const y=rt(A,I);p={basesCovered:j(y,0),scoreMin:y.getFloat64(8,!0),scoreMax:y.getFloat64(16,!0),scoreSum:y.getFloat64(24,!0),scoreSumSquares:y.getFloat64(32,!0)}}else throw new Error("no stats");let w="";if(u){const y=A.indexOf(0,u),N=y===-1?A.length:y;w=As.decode(A.subarray(u,N))}return{zoomLevels:B,magic:o,extHeaderOffset:C,numZoomLevels:a,fieldCount:f,totalSummary:p,definedFieldCount:h,uncompressBufSize:d,asOffset:u,chromosomeTreeOffset:c,totalSummaryOffset:I,unzoomedDataOffset:l,unzoomedIndexOffset:g,fileType:Q,version:i,autoSql:w}}async _readChromosomeTree(e,n){const A=[],s={},r=e.chromosomeTreeOffset,o=rt(await this.bbi.read(32,r,n)),i=o.getUint32(4,!0),a=o.getUint32(8,!0),c=o.getUint32(12,!0),l=4+i*(a+Math.max(c,8)),g=async f=>{const h=await this.bbi.read(l,f,n),u=rt(h),I=u.getUint8(0),d=u.getUint16(2,!0);let C=4;if(I)for(let B=0;B<d;B++){const Q=CA(h,C,a);C+=a;const E=u.getUint32(C,!0);C+=4;const m=u.getUint32(C,!0);C+=4,s[Q]=E,A[E]={name:Q,id:E,length:m}}else{const B=[];for(let Q=0;Q<d;Q++){C+=a;const E=j(u,C);C+=8,B.push(g(E))}await Promise.all(B)}};return await g(r+32),{refsByName:s,refsByNumber:A}}viewCache=new Map;getOrCreateBlockView(e,n,A,s){const r=`${n}_${s}`;let o=this.viewCache.get(r);return o||(o=new Hc(this.bbi,e,n,A,s),this.viewCache.set(r,o)),o}async getUnzoomedView(e){const{unzoomedIndexOffset:n,refsByName:A,uncompressBufSize:s,fileType:r}=await this.getHeader(e);return this.getOrCreateBlockView(A,n,s,r)}async _getView(e){const{basesPerSpan:n,scale:A}=e??{},s=n?1/n:A??1;return this.getView(s,e)}async getFeatures(e,n,A,s){return(await this._getView(s)).readWigData(e,n,A,s)}async getRegionByteSize(e,n,A,s){return(await this._getView(s)).getBlockSizeForRange(e,n,A,s)}async getRegionByteSizeMulti(e,n){return(await this._getView(n)).getBlockSizeForRangeMulti(e,n)}async getFeaturesMulti(e,n){return(await this._getView(n)).readWigDataMulti(e,n)}async getFeaturesAsArrays(e,n,A,s){return(await this._getView(s)).readWigDataAsArrays(e,n,A,s)}async getFeaturesAsArraysMulti(e,n){return(await this._getView(n)).readWigDataAsArraysMulti(e,n)}}class Jo extends $o{async getView(e,n){const{zoomLevels:A,refsByName:s,uncompressBufSize:r}=await this.getHeader(n),o=1/e,i=A.length-1;for(let a=i;a>=0;a-=1){const c=A[a];if(c.reductionLevel<=2*o)return this.getOrCreateBlockView(s,c.indexOffset,r,"summary")}return this.getUnzoomedView(n)}}function Pc(t,e){if(e<0)return;let n=0;for(let s=0;s<e;s++){if(n=t.indexOf("	",n),n===-1)return;n++}const A=t.indexOf("	",n);return A===-1?t.slice(n):t.slice(n,A)}function Ps(t,e){return t<e?-1:t>e?1:0}async function Oo(t,e,n,A,s,r,o,i){const a=4+n*(A+s),c=await t.read(a,e,i),l=rt(c),g=l.getInt8(0),f=l.getInt16(2,!0);let h=4;if(g===0){const u=[];for(let Q=0;Q<f;Q++){const E=CA(c,h,A);h+=A;const m=j(l,h);h+=8,u.push({key:E,offset:m})}let I=0,d=u.length-1,C=-1;for(;I<=d;){const Q=Math.floor((I+d)/2);Ps(r,u[Q].key)>=0?(C=Q,I=Q+1):d=Q-1}const B=u[Math.max(C,0)].offset;return Oo(t,B,n,A,s,r,o,i)}else if(g===1){const u=[];for(let E=0;E<f;E++){const m=CA(c,h,A);h+=A;const p=j(l,h);h+=8;const w=l.getUint32(h,!0);h+=4,h+=4,u.push({key:m,offset:p,length:w})}let I=0,d=u.length-1,C=-1;for(;I<=d;){const E=Math.floor((I+d)/2),m=Ps(r,u[E].key);if(m===0){C=E;break}else m<0?d=E-1:I=E+1}if(C===-1)return[];let B=C;for(;B>0&&u[B-1].key===r;)B--;let Q=C;for(;Q<u.length-1&&u[Q+1].key===r;)Q++;return u.slice(B,Q+1).map(E=>({...E,field:o}))}return[]}class Yo extends $o{indicesP;readIndices(e={}){return this.indicesP||(this.indicesP=this._readIndices(e).catch(n=>{throw this.indicesP=void 0,n})),this.indicesP}async getView(e,n){return this.getUnzoomedView(n)}async _readIndices(e){const{extHeaderOffset:n}=await this.getHeader(e);if(n===0)return[];const A=await this.bbi.read(64,n,e),s=rt(A),r=s.getUint16(2,!0),o=j(s,4);if(r===0)return[];const i=20,a=i*r,c=await this.bbi.read(a,o,e),l=[];for(let g=0;g<r;g+=1){const f=rt(c,g*i),h=f.getInt16(0,!0),u=f.getInt16(2,!0),I=j(f,4),d=f.getInt16(16,!0);l.push({type:h,fieldcount:u,offset:I,field:d})}return l}async searchExtraIndexBlocks(e,n={}){const A=await this.readIndices(n);if(A.length===0)return[];const s=A.map(async o=>{const{offset:i,field:a}=o,c=await this.bbi.read(32,i,n),l=rt(c),g=l.getInt32(4,!0),f=l.getInt32(8,!0),h=l.getInt32(12,!0);return Oo(this.bbi,i+32,g,f,h,e,a,n)});return(await Promise.all(s)).flat()}async searchExtraIndex(e,n={}){const A=await this.searchExtraIndexBlocks(e,n);if(A.length===0)return[];const s=await this.getUnzoomedView(n),r=new Map;for(const i of A){const a=i.field??0,c=r.get(a);c?c.set(i.offset,i):r.set(a,new Map([[i.offset,i]]))}return(await Promise.all([...r].map(async([i,a])=>(await s.readFeatures([...a.values()],n)).map(l=>({...l,field:i}))))).flat().filter(i=>i.rest?Pc(i.rest,i.field-3)===e:!1)}}const zc=["exact","case","decorated","prefix","padded","roman","organelle","accession","version"],zs=new Set(["gi","gb","ref","emb","dbj","tpg","tpe","tpd","lcl","pir","prf","sp","tr","pdb","ena","bbs"]);function ss(t){let e=t.trim().split(/\s+/)[0]??"";if(e=e.replace(/[,;]+$/,""),e.includes("|")){const n=e.split("|").filter(A=>A!=="");if(n.some(A=>zs.has(A.toLowerCase()))){const A=n.filter((s,r)=>zs.has(s.toLowerCase())?!1:!(/^[0-9]+$/.test(s)&&r>0&&n[r-1].toLowerCase()==="gi"));A.length>0&&(e=A[A.length-1])}}return e}const _o=/^(?:chromosome|chrom|chr)[ _.-]?/i;function Ko(t){const e=t.replace(_o,"");if(e===""||e===t)return null;const n=e.toLowerCase();return/^[0-9]/.test(e)||mn.has(n)||En.has(n)||Tn(e)>0||/^un[_.-]/i.test(e)||/^[A-Za-z]{1,2}[0-9]/.test(e)||Ho.test(e)||Wo.test(e.replace(/\.[0-9]+$/,""))?e:null}const Xc=/^(?:lg|linkage_?group|group)[ _.-]?(?=[0-9])/i,qo=/_(random|alt|fix|hap\d+|maternal|paternal)$/i,Vc=/(?:^|[_.-])([A-Z]{2}[0-9]{5,6})v([0-9]+)(?:$|[_.-])/,Ho=/^(N[CGTWZ]|AC)_([0-9]{5,})$/i,Wo=/^[A-Z]{1,6}[0-9]{5,8}$/,Zc=[["mito",["m","mt","mtdna","mito","mitochondrion","mitochondria","mitochondrial","mitochondrion_genome","dmel_mitochondrion_genome","mitochondrial_genome","mitochondrion_dna","chrmt","nc_012920","j01415","nc_001224","nc_005089"]],["plastid",["c","pt","cp","chloroplast","plastid","chloroplast_genome","chrc","nc_000932"]],["2micron",["2-micron","2micron","2u","2-micron_plasmid","nc_001398"]]],En=new Map;for(const[t,e]of Zc)for(const n of e)En.set(n,t);const mn=new Set(["x","y","z","w"]),jc=/^(XL|L|X{0,3})(IX|IV|V?I{0,3})$/i,tl={"":0,x:10,xx:20,xxx:30,xl:40,l:50},el={"":0,i:1,ii:2,iii:3,iv:4,v:5,vi:6,vii:7,viii:8,ix:9};function Tn(t){const e=jc.exec(t);if(e===null)return 0;const n=tl[e[1].toLowerCase()],A=el[e[2].toLowerCase()];return n===void 0||A===void 0?0:n+A}const nl=[{from:1,to:22,first:1,tail:["x","y"]},{from:67,to:85,first:1,tail:["x","y"]}];function Al(t){for(const e of nl){if(t>=e.from&&t<=e.to)return String(e.first+(t-e.from));const n=t-e.to-1;if(n>=0&&n<e.tail.length)return e.tail[n]}return null}const QA=200;function sl(t){return t.length<2||mn.has(t.toLowerCase())?!1:Tn(t)>0}function Po(t){const e=t.map(a=>zo(a)),A=e.filter(a=>sl(a)).length>=2,s=e.filter(a=>/^[0-9]+$/.test(a)&&Number(a)>=1&&Number(a)<=QA),r=s.length<QA,o=a=>e.some(c=>c.toLowerCase()===a),i=r&&s.length>=2;return{roman:A,ordinals:r,xIsTen:A&&!i&&(o("ix")||o("xi"))}}function zo(t){const e=ss(t);return(Ko(e)??e).replace(qo,"")}function gn(t,e){const n=[],A=ss(t);A!==t.trim()&&n.push("decorated");const s=Ko(A),r=s??A;s!==null&&n.push("prefix");const o=qo.exec(r),i=o===null?r:r.slice(0,o.index),a=o===null?"":`+${o[1].toLowerCase()}`,c=i.toLowerCase(),l=Vc.exec(r);if(l!==null)return n.push("accession"),{key:`acc:${l[1].toLowerCase()}`,via:n,version:l[2],opaque:!1};const g=/^(.*?)\.([0-9]+)$/.exec(i),f=g===null?i:g[1],h=g===null?null:g[2],u=En.get(c)??En.get(f.toLowerCase());if(u!==void 0)return u!==c&&n.push("organelle"),{key:`org:${u}`,via:n,version:h,opaque:!1};const I=Ho.exec(f);if(I!==null){n.push("accession");const B=I[1].toLowerCase()==="nc"?Al(Number(I[2])):null;return B!==null?{key:mn.has(B)?`sex:${B}${a}`:`num:${B}${a}`,via:n,version:h,opaque:!1}:{key:`acc:${f.toLowerCase()}${a}`,via:n,version:h,opaque:!1}}if(Wo.test(f))return n.push("accession"),{key:`acc:${f.toLowerCase()}${a}`,via:n,version:h,opaque:!1};if(/^[0-9]+$/.test(i)&&e.ordinals&&Number(i)<=QA)return/^0[0-9]/.test(i)&&n.push("padded"),{key:`num:${Number(i)}${a}`,via:n,version:null,opaque:!1};const d=/^([0-9]{1,2})([a-z]{1,2})$/i.exec(i);if(d!==null&&e.ordinals)return d[1].startsWith("0")&&n.push("padded"),{key:`num:${Number(d[1])}${d[2].toLowerCase()}${a}`,via:n,version:null,opaque:!1};const C=Xc.exec(i);if(C!==null){const B=i.slice(C[0].length);if(/^[0-9]+$/.test(B))return/^0[0-9]/.test(B)&&n.push("padded"),{key:`lg:${Number(B)}${a}`,via:n,version:null,opaque:!1}}if(mn.has(c)&&!(c==="x"&&e.xIsTen))return{key:`sex:${c}${a}`,via:n,version:null,opaque:!1};if(e.roman){const B=Tn(i);if(B>0)return n.push("roman"),{key:`num:${B}${a}`,via:n,version:null,opaque:!1}}return{key:`raw:${c}${a}`,via:n,version:null,opaque:!0}}function Ee(t){return zc.indexOf(t)}function rl(t,e){let n="case";for(const A of[...t.via,...e.via])Ee(A)>Ee(n)&&(n=A);return n}function tA(t,e){return t===void 0||e===void 0||t<=0||e<=0?"unknown":t===e?"agree":"differ"}const Xs=new WeakMap;class St{names;context;styleCache=null;get style(){return this.styleCache??=il(this.names,this.context),this.styleCache}exact=new Map;folded=new Map;keyed=new Map;constructor(e){this.names=e.map(n=>n.name),this.context=Po(this.names);for(const n of e){this.exact.has(n.name)||this.exact.set(n.name,n),Vs(this.folded,n.name.toLowerCase(),n);const A=gn(n.name,this.context);Vs(this.keyed,A.key,{sequence:n,canon:A})}}static of(e){return new St(e)}static ofNames(e){return new St(e.map(n=>({name:n})))}static for(e){const n=Xs.get(e);if(n!==void 0)return n;const A=typeof e[0]=="string"?St.ofNames(e):St.of(e);return Xs.set(e,A),A}has(e){return this.exact.has(e)}find(e,n={}){const{length:A}=n,s=this.exact.get(e);if(s!==void 0)return{name:s.name,asked:e,tier:"exact",lengths:tA(A,s.length)};const r=this.folded.get(e.toLowerCase());if(r!==void 0&&r.length===1)return{name:r[0].name,asked:e,tier:"case",lengths:tA(A,r[0].length)};const o=n.from??this.context,i=this.byKey(e,gn(e,o),A);if(i!==null)return i;if(!o.roman){const a=zo(e).toLowerCase();if(a!=="x"&&a!=="l"&&Tn(a)>0)return this.byKey(e,gn(e,{...o,roman:!0,xIsTen:!1}),A)}return null}byKey(e,n,A){const s=this.keyed.get(n.key);if(s===void 0||s.length===0)return null;const r=ol(s,A);if(r===null)return null;const o=rl(n,r.canon),i=n.version!==null&&r.canon.version!==null&&n.version!==r.canon.version;return{name:r.sequence.name,asked:e,tier:i&&Ee(o)<Ee("version")?"version":o,lengths:tA(A,r.sequence.length)}}}function ol(t,e){if(t.length===1)return t[0];if(e===void 0||e<=0)return null;const n=t.filter(A=>A.sequence.length===e);return n.length===1?n[0]:null}function Vs(t,e,n){const A=t.get(e);A===void 0?t.set(e,[n]):A.push(n)}function il(t,e=Po(t)){if(t.length===0)return"empty";let n=0,A=0,s=0,r=0;for(const i of t){const a=gn(i,e);if(a.opaque){r++;continue}a.via.includes("accession")?s++:_o.test(ss(i))?n++:A++}const o=n+A+s;return o===0||r>o*4?"assembly":e.roman&&n<=A?"roman":s>n&&s>A?"accession":n>0&&A>0?"mixed":n>0?e.roman?"roman":"ucsc":e.roman?"roman":"ensembl"}function al(t,e){const n=St.of(e),A=St.of(t).context,s=[];for(const g of t){const f=n.find(g.name,{length:g.length,from:A});f!==null&&s.push({source:g,match:f})}s.sort((g,f)=>Ee(g.match.tier)-Ee(f.match.tier));const r=new Map,o=new Set;for(const g of s){const f=r.get(g.match.name);f===void 0?r.set(g.match.name,{source:g.source.name,tier:g.match.tier}):f.tier===g.match.tier&&o.add(g.match.name)}const i=new Map,a=[];let c=0;for(const g of s){const f=r.get(g.match.name);f===void 0||f.source!==g.source.name||o.has(g.match.name)||(i.set(g.source.name,g.match),g.match.tier!=="exact"&&c++,g.match.lengths==="differ"&&a.push(g.match))}const l=t.map(g=>g.name).filter(g=>!i.has(g));return{pairs:i,unmatched:l,contested:a,renamed:c}}function pe(t,e){const n=al(t,e),A=new Map,s=t.map(r=>{const o=n.pairs.get(r.name);return o===void 0?r.name:(A.set(o.name,r.name),o.name)});for(const r of t)A.has(r.name)||A.set(r.name,r.name);return{names:s,sourceOf:A,renamed:n.renamed,contested:n.contested}}function cl(t){return t.map(e=>({name:e}))}function Kt(t,e){const n=ll(t),A=n.get(e);if(A!==void 0)return A;const s=St.for(t).find(e);return s===null?-1:n.get(s.name)??-1}const Zs=new WeakMap;function ll(t){const e=Zs.get(t);if(e!==void 0)return e;const n=new Map;return t.forEach((A,s)=>{const r=typeof A=="string"?A:A.name;n.has(r)||n.set(r,s)}),Zs.set(t,n),n}class Rt extends Error{code;detail;constructor(e,n,A={}){super(n),this.name="ViewerError",this.code=e,this.detail=A}}const eA=new Intl.NumberFormat(void 0,{maximumFractionDigits:0}),gl=new Intl.NumberFormat(void 0,{maximumFractionDigits:3}),fl=new Intl.NumberFormat(void 0,{maximumSignificantDigits:3}),js=new Map,hl=new Intl.NumberFormat("en-US",{maximumFractionDigits:0}),x={int(t){return Number.isFinite(t)?eA.format(t):"—"},num(t){if(!Number.isFinite(t))return"—";if(Number.isInteger(t))return eA.format(t);const e=Math.abs(t);return e>=.001?gl.format(t):e>=1e-7?fl.format(t):t.toExponential(2)},fixed(t,e){if(!Number.isFinite(t))return"—";let n=js.get(e);return n===void 0&&(n=new Intl.NumberFormat(void 0,{minimumFractionDigits:e,maximumFractionDigits:e}),js.set(e,n)),n.format(t)},pct(t,e=1){return Number.isFinite(t)?`${(t*100).toFixed(e)}%`:"—"},pos(t){return Number.isFinite(t)?hl.format(Math.round(t)):"—"},bp(t){return Number.isFinite(t)?Math.abs(t)>=1e6?`${(t/1e6).toFixed(2)} Mb`:Math.abs(t)>=1e3?`${(t/1e3).toFixed(1)} kb`:`${eA.format(t)} bp`:"—"},bytes(t){if(!Number.isFinite(t))return"—";const e=["B","kB","MB","GB","TB"];let n=t,A=0;for(;n>=1e3&&A<e.length-1;)n/=1e3,A++;return`${A===0?n:n.toFixed(1)} ${e[A]}`}};function Xo(t){return!Number.isFinite(t)||t<=0?"—":t>=1e6?`${nA(t/1e6)} Mb`:t>=1e3?`${nA(t/1e3)} kb`:`${nA(t)} bp`}function nA(t){return String(Number(t.toFixed(2)))}function nt(t,e){const n=Il(t),A=dl(n,e);if(A===null)return n;throw new Rt("format",`The ${e.field} of this ${e.format} reads ${EA(t)}, ${A.reason}. `+de,{format:e.format,field:e.field,value:typeof t=="bigint"?t.toString():t,ceiling:e.ceiling,...e.available===void 0?{}:{available:e.available},...A.most===void 0?{}:{most:A.most}})}function rs(t,e,n){const A={format:n.format,field:n.field,offset:t,length:e,size:n.size};if(!BA(t)||!BA(e))throw new Rt("format",`The 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+`,g);N<0&&(N=f);let k=N;k>g&&t.charCodeAt(k-1)===13&&k--;const b=t.slice(g,k);if(g=N+1,b.startsWith(`${lr} `)){const G=b.slice(lr.length+1).trim().split(/\s+/),[O,...$]=G;if(O==="PLACEMENT")s=Number($[0]);else if(O==="FRAME"&&$.length===4){const[K,V,H,ht]=$.map(Number);[K,V,H].every(Number.isFinite)&&ht>0&&(r={cx:K,cy:V,cz:H,factor:ht})}else if(O==="WIDTH"){const K=Number($[0]);Number.isInteger(K)&&K>0&&(o=K)}else if(O==="HAPLOTYPES")i=$.map(sA);else if(O==="CHAIN"&&$.length>=6){const K=Number($[2]),V=Number($[3]);en(K)&&en(V)&&K<=V&&n.push({first:K,last:V,hap:sA($[4]),sequence:sA($.slice(5).join(" "))})}else if(O==="RUN"&&$.length===4){const[K,V,H,ht]=$.map(Number);en(K)&&Number.isInteger(V)&&V>0&&K+V-1<=fe&&Number.isInteger(H)&&H>=0&&Number.isInteger(ht)&&ht>0&&A.push({first:K,count:V,start:H,width:ht})}continue}if(l)continue;if(b.startsWith("ENDMDL")){l=!0;continue}if(!b.startsWith("HETATM")&&!b.startsWith("ATOM  "))continue;const M=Number(b.slice(6,11)),F=Number(b.slice(30,38)),S=Number(b.slice(38,46)),v=Number(b.slice(46,54));!en(M)||!Vg(F,S,v)||(b.slice(17,20)===Xg&&c++,a.push({serial:M,x:F,y:S,z:v}))}const h=e===""?"This file":e;if(a.length===0)throw new Error(`${h} has no ATOM or HETATM record with a place, so there is no bead to read.`);if(s===null||n.length===0||A.length===0)throw new Error(c===a.length?"These beads are named the way this app writes a PDB, but the lines that said where each one is on the genome are gone: PyMOL drops REMARK records when it saves. Open the PDB as this app wrote it, or its bed3d.":"A PDB says where each bead is in space and not where it is on the genome, and this one does not say: pastis and the other solvers write their beads in bin order and nothing else. Write the coordinates beside the bins they were modelled at, as a bed3d (chrom, start, end, x, y, z), and open that.");if(s!==gr)throw new Error(`This PDB's placement table is version ${String(s)}, and this reader understands version ${gr}.`);const u=new Int32Array(fe+1).fill(-1);n.forEach((N,k)=>{for(let b=N.first;b<=N.last;b++)u[b]=k});const I=new Float64Array(fe+1).fill(-1),d=new Float64Array(fe+1);for(const N of A)for(let k=0;k<N.count;k++)I[N.first+k]=N.start+k*N.width,d[N.first+k]=N.width;const C=i??[],B=new Map;C.forEach((N,k)=>B.set(N,k));const Q=r??{cx:0,cy:0,cz:0,factor:1},E=new Uint8Array(fe+1),m=[];for(const N of a){const k=u[N.serial],b=I[N.serial];if(k<0||b<0||E[N.serial]===1)continue;E[N.serial]=1;const M=n[k];B.has(M.hap)||(B.set(M.hap,C.length),C.push(M.hap)),m.push({contig:M.sequence,start:b,end:b+d[N.serial],xyz:[N.x/Q.factor+Q.cx,N.y/Q.factor+Q.cy,N.z/Q.factor+Q.cz],hap:M.hap})}if(m.length===0)throw new Error(`${h} has a placement table, and it places none of the file's ${x.int(a.length)} atoms.`);const p=C.length>1,w=new et;for(const N of m)w.add(N.contig,N.start,N.end,{xyz:N.xyz,hap:B.get(N.hap)??0,detail:p?`${us} ${N.hap}`:""});const y={width:o??Zg(m.map(N=>N.end-N.start)),haplotypes:C};return w.finish(null,y)}function en(t){return Number.isInteger(t)&&t>=1&&t<=fe}function sA(t){try{return decodeURIComponent(t)}catch{return t}}function Zg(t){const e=new Map;for(const s of t)s>0&&e.set(s,(e.get(s)??0)+1);let n=0,A=1;for(const[s,r]of e)(r>n||r===n&&s<A)&&(n=r,A=s);return A}const rA="MessagePack value",fr=64,jg=BigInt(Number.MAX_SAFE_INTEGER),tf=BigInt(Number.MIN_SAFE_INTEGER);function bi(t,e=0){const n=new ef(t,e);return{value:n.next(),end:n.at}}class ef{constructor(e,n){this.bytes=e,this.at=n,this.view=new DataView(e.buffer,e.byteOffset,e.byteLength)}at;view;decoder=new TextDecoder;depth=0;next(){const e=this.u8();if(e<=127)return e;if(e>=224)return e-256;if(e>=128&&e<=143)return this.map(e&15);if(e>=144&&e<=159)return this.array(e&15);if(e>=160&&e<=191)return this.str(e&31);switch(e){case 192:return null;case 194:return!1;case 195:return!0;case 196:return this.bin(this.u8());case 197:return this.bin(this.u16());case 198:return this.bin(this.u32());case 202:return this.f32();case 203:return this.f64();case 204:return this.u8();case 205:return this.u16();case 206:return this.u32();case 207:return this.big(this.view.getBigUint64(this.take(8)));case 208:return this.i8();case 209:return this.i16();case 210:return this.i32();case 211:return this.big(this.view.getBigInt64(this.take(8)));case 217:return this.str(this.u8());case 218:return this.str(this.u16());case 219:return this.str(this.u32());case 220:return this.array(this.u16());case 221:return this.array(this.u32());case 222:return this.map(this.u16());case 223:return this.map(this.u32());default:throw new Error(`msgpack: unsupported type byte 0x${e.toString(16).padStart(2,"0")} at offset ${this.at-1}.`)}}take(e){const n=this.at;if(n+e>this.bytes.length)throw new Error(`msgpack: truncated: needed ${e} byte${e===1?"":"s"} at offset ${n} of ${this.bytes.length}.`);return this.at=n+e,n}u8(){return this.view.getUint8(this.take(1))}u16(){return this.view.getUint16(this.take(2))}u32(){return this.view.getUint32(this.take(4))}i8(){return this.view.getInt8(this.take(1))}i16(){return this.view.getInt16(this.take(2))}i32(){return this.view.getInt32(this.take(4))}f32(){return this.view.getFloat32(this.take(4))}f64(){return this.view.getFloat64(this.take(8))}big(e){if(e>jg||e<tf)throw new Error(`msgpack: the 64-bit integer ${e} at offset ${this.at-9} does not fit a JavaScript number.`);return Number(e)}str(e){const n=this.take(e);return this.decoder.decode(this.bytes.subarray(n,n+e))}bin(e){const n=this.take(e);return this.bytes.subarray(n,n+e)}open(e,n,A){if(this.depth>=fr)throw new Rt("format",`This ${rA} nests deeper than ${fr} levels at offset ${this.at}, which no document this reader opens does. The file is corrupt, or not the format its first bytes claim.`,{format:rA,offset:this.at,depth:this.depth});return this.depth++,nt(e,{format:rA,field:`${n} length at offset ${this.at}`,ceiling:2**32-1,available:this.bytes.length-this.at,bytesPerItem:A})}array(e){const n=this.open(e,"array",1),A=new Array(n);for(let s=0;s<n;s++)A[s]=this.next();return this.depth--,A}map(e){const n=this.open(e,"map",2),A=new Map;for(let s=0;s<n;s++){const r=this.at,o=this.next();if(typeof o!="string"&&typeof o!="number")throw new Error(`msgpack: a map key at offset ${r} is neither a string nor an integer.`);A.set(o,this.next())}return this.depth--,A}}const hr=64e3,yn="binary g3d",Mi={ratio:64,floor:64<<20,ceiling:1<<30},nf=[165,109,97,103,105,99],Af=[163,71,51,68];function ds(t){if(t.length===0)return!1;const e=t[0];let n;if(e>=128&&e<=143)n=1;else if(e===222)n=3;else return!1;const A=[...nf,...Af];if(t.length<n+A.length)return!1;for(let s=0;s<A.length;s++)if(t[n+s]!==A[s])return!1;return!0}async function sf(t,e){const n=e===void 0?hr:Math.min(hr,e),A=await t(n,0);if(!ds(A))throw new Error("Not a binary g3d: the file does not begin with the G3D magic.");const{value:s}=bi(A);if(!(s instanceof Map))throw new Error("Not a binary g3d: the header is not a map.");if(s.get("magic")!=="G3D")throw new Error('Not a binary g3d: the magic is not "G3D".');const r=s.get("version");if(r!==2)throw r===1?new Error("This is a version-1 g3d, written by a g3dtools older than 0.2. 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It is truncated; rebuild it with \`samtools index\`.`,{bytes:e.byteLength}):A}}function Ef(t){const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=o=>t.byteLength-o,A=nt(e.getInt32(4,!0),{format:Qt,field:"reference count",ceiling:he,available:n(8),bytesPerItem:8});let s=8;const r=[];for(let o=0;o<A;o++){const i=new Map,a=nt(e.getInt32(s,!0),{format:Qt,field:`bin count of reference ${o}`,ceiling:If,available:n(s+4)-4,bytesPerItem:8});s+=4;for(let g=0;g<a;g++){const f=e.getUint32(s,!0);s+=4;const h=nt(e.getInt32(s,!0),{format:Qt,field:`chunk count of bin ${f}`,ceiling:he,available:n(s+4),bytesPerItem:16});s+=4;const u=[];for(let I=0;I<h;I++)u.push({begin:e.getBigUint64(s,!0),end:e.getBigUint64(s+8,!0)}),s+=16;f!==uf&&i.set(f,u)}const c=nt(e.getInt32(s,!0),{format:Qt,field:`linear index size of reference ${o}`,ceiling:df,available:n(s+4),bytesPerItem:8});s+=4;const l=new BigUint64Array(c);for(let g=0;g<c;g++)l[g]=e.getBigUint64(s,!0),s+=8;r.push({bins:i,linear:l,loffset:null})}return{format:"bai",minShift:ff,depth:hf,refs:r}}function mf(t){const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=c=>t.byteLength-c,A=nt(e.getInt32(8,!0),{format:Qt,field:"CSI depth",ceiling:Cf}),s=nt(e.getInt32(4,!0),{format:Qt,field:"CSI min_shift",ceiling:Qf-3*A});let o=16+nt(e.getInt32(12,!0),{format:Qt,field:"auxiliary data length",ceiling:he,available:n(16)-4});const i=nt(e.getInt32(o,!0),{format:Qt,field:"reference count",ceiling:he,available:n(o+4),bytesPerItem:4});o+=4;const a=[];for(let c=0;c<i;c++){const l=new Map,g=new Map,f=nt(e.getInt32(o,!0),{format:Qt,field:`bin count of reference ${c}`,ceiling:he,available:n(o+4),bytesPerItem:16});o+=4;for(let h=0;h<f;h++){const u=e.getUint32(o,!0);o+=4,g.set(u,e.getBigUint64(o,!0)),o+=8;const I=nt(e.getInt32(o,!0),{format:Qt,field:`chunk count of bin ${u}`,ceiling:he,available:n(o+4),bytesPerItem:16});o+=4;const d=[];for(let C=0;C<I;C++)d.push({begin:e.getBigUint64(o,!0),end:e.getBigUint64(o+8,!0)}),o+=16;l.set(u,d)}a.push({bins:l,linear:null,loffset:g})}return{format:"csi",minShift:s,depth:A,refs:a}}function Je(t,e){return Math.floor(t/2**e)}function wf(t,e,n,A){const s=[],r=Math.max(e,n-1);let o=A.minShift+A.depth*3,i=0;for(let a=0;a<=A.depth;a++){const c=i+Je(e,o),l=i+Je(r,o);if(l-c+1>t.bins.size)for(const[g,f]of t.bins)g>=c&&g<=l&&s.push(f);else for(let g=c;g<=l;g++){const f=t.bins.get(g);f!==void 0&&s.push(f)}i+=1<<a*3,o-=3}return s}function pf(t,e,n){if(t.linear!==null){const r=Je(e,n.minShift);return t.linear.length===0?0n:t.linear[Math.min(r,t.linear.length-1)]}if(t.loffset===null)return 0n;let A=n.minShift,s=0;for(let r=n.depth;r>=0;r--){s=Di(r);const o=t.loffset.get(s+Je(e,A));if(o!==void 0)return o;A+=3}return 0n}function Di(t){let e=0;for(let n=0;n<t;n++)e+=1<<n*3;return e}function yf(t,e,n){let A=null,s=n.minShift;for(let r=n.depth;r>=0;r--){const o=Di(r),i=1<<r*3,a=Je(Math.max(0,e-1),s)+1;for(let c=0;c<8&&a+c<i;c++){const l=t.bins.get(o+a+c);if(l!==void 0)for(const g of l)(A===null||g.begin<A)&&(A=g.begin)}s+=3}return A??BigInt(Number.MAX_SAFE_INTEGER)<<16n}const Nf=1<<20;function kf(t,e,n,A,s){const r=t.refs[e];if(r===void 0)return[];const o=pf(r,Math.max(0,n),t),i=yf(r,Math.max(1,A),t),a=[];for(const l of wf(r,Math.max(0,n),Math.max(1,A),t))for(const g of l)g.end>o&&g.begin<i&&a.push(g);if(a.length===0)return[];a.sort((l,g)=>l.begin<g.begin?-1:l.begin>g.begin?1:0);const c=[];for(const l of a){const g=Number(l.begin>>16n),f=Number(l.begin&0xffffn),h=Number(l.end>>16n),u=Math.min(s,h+Et),I=c[c.length-1];I!==void 0&&g<=I.to+Nf?(I.to=Math.max(I.to,u),I.lastBlock=Math.max(I.lastBlock,h)):c.push({from:g,to:u,lastBlock:h,dataFrom:f})}return c}function Fi(t){let e=0;for(const n of t)e+=n.to-n.from;return e}const bf=2*Et,Mf=Et,Ir=1<<20,Df=4*Et,Ff=16384,Sf=1<<24,Rf=1<<18,Lf=1<<24,Nn=18,Pt=[31,139,8,4],me=36;function jt(t,e){return t<0?Number.POSITIVE_INFINITY:t*2**32+e+1}class NA extends Error{constructor(e,n){super("The reads are not in coordinate order."),this.before=e,this.after=n,this.name="UnsortedError"}}function dr(t,e){return t.refId<0?"unplaced":`${e[t.refId]?.name??`reference ${t.refId}`}:${(t.pos+1).toLocaleString("en-US")}`}function Gf(t,e){const n=e-1;return t>>14===n>>14?32767/7+(t>>14):t>>17===n>>17?4095/7+(t>>17):t>>20===n>>20?511/7+(t>>20):t>>23===n>>23?63/7+(t>>23):t>>26===n>>26?7/7+(t>>26):0}class Cs{constructor(e,n,A,s){this.handle=e,this.size=n,this.refs=A,this.progress=s,this.lineStart=[];let r=0;for(const o of A)this.lineStart.push(r),r+=Math.max(0,o.length);this.lineLength=r}probes=[];answers=new Map;probing=new Map;lastWalk=null;walking=new Map;bytesRead=0;first=null;lineStart;lineLength;static async open(e,n,A,s,r){const o=new Cs(e,n,A.refs,s);if(o.first=await o.firstRecord(A.recordsFrom),o.first!==null&&A.sortOrder!=="coordinate")for(const i of[.125,.375,.625,.875])r!==void 0&&await r(),await o.probeAt(Math.floor(n*i));return o}get bytes(){return this.bytesRead}get probeCount(){return this.probes.length}async spansFor(e,n,A,s,r){if(this.first===null||A<=n)return[];const o=await this.locate(e,Math.max(0,n-Ff),s);if(o===null||o.key>=jt(e,A))return[];if(r!==void 0&&o.block+r<this.size){s!==void 0&&await s();const c=await this.probeAt(Cr(o.block+r,o.block));if(c.key<jt(e,A)){const l=c.block;return[{from:o.block,to:Math.min(this.size,l+Et),lastBlock:l,dataFrom:o.within}]}}const i=await this.locate(e,A,s),a=i===null||i.tail===!0?this.size:i.block;return[{from:o.block,to:Math.min(this.size,a+Et),lastBlock:a,dataFrom:o.within}]}locate(e,n,A){if(this.first===null)return Promise.resolve(null);const s=jt(e,n);if(this.first.key>=s)return Promise.resolve(this.first);const r=this.answers.get(s);if(r!==void 0)return r;const o=this.search(e,n,A).then(i=>(i!==null&&i.tail!==!0&&this.remember(i,!0),i));return this.answers.set(s,o),o.catch(()=>this.answers.delete(s)),o}async search(e,n,A){if(this.first===null)return null;const s=jt(e,n);let r=this.first,o=null;for(const c of this.probes)if(c.key<s)r=c;else{o=c;break}let i=!0;for(;;){const c=o===null?this.size:o.block,l=c-r.block;if(l<=Df)break;A!==void 0&&await A();const g=i?this.guess(r,o,e,n):null,f=await this.probeAt(Cr(g??Math.floor((r.block+c)/2),r.block));if(f.block>=c)break;f.key>=s?o=f:r=f,i=(o===null?this.size:o.block)-r.block<=l/2}const a=o===null||o.tail===!0?this.size:Math.min(this.size,o.block+Et);return this.walk(r,a,s)}lineOf(e,n){return(this.lineStart[e]??this.lineLength)+Math.max(0,n)}guess(e,n,A,s){const r=this.lineOf(A,s),o=this.lineOf(e.refId,e.pos),i=n===null||n.tail===!0||n.refId<0?this.lineLength:this.lineOf(n.refId,n.pos);if(i<=o)return null;const a=(r-o)/(i-o);if(!(a>0&&a<1))return null;const c=n===null?this.size:n.block,l=e.block+Math.floor(a*(c-e.block));return Math.min(Math.max(l,e.block+1),c-2*Et)}async walk(e,n,A){if(n<=e.block)return null;let s=this.lastWalk;if(s===null||e.block<s.from||n>s.to){const c=`${e.block}-${n}`;let l=this.walking.get(c);if(l===void 0){l=this.read(n-e.block,e.block).then(async f=>{const{bytes:h,blocks:u}=await kA(f,e.block);return{from:e.block,to:n,bytes:h,blocks:u}}),this.walking.set(c,l);const g=()=>{this.walking.delete(c)};l.then(g,g)}s=await l,this.lastWalk=s}const{bytes:r,blocks:o}=s,i=o.find(c=>c.fileAt===e.block);if(i===void 0)return this.lastWalk=null,this.walk(e,n,A);let a=null;return wn(r,i.from+e.within,c=>jt(c.refId,c.pos)<A?!0:(a=bA(o,c.at-4,c.refId,c.pos),!1)),a}probeAt(e){const n=this.probing.get(e);if(n!==void 0)return n;const A=this.probe(e);this.probing.set(e,A);const s=()=>{this.probing.delete(e)};return A.then(s,s),A}async probe(e){let n=bf;for(;;){const A=Math.min(this.size,e+n);if(A<=e)return this.remember({block:e,within:0,refId:-1,pos:-1,key:Number.POSITIVE_INFINITY,tail:!0});const s=await this.read(A-e,e),r=await vf(s,e,this.refs,this.size);if(r.kind==="record")return this.remember(r.placed);if(r.kind==="end"||A>=this.size)return this.remember({block:e,within:0,refId:-1,pos:-1,key:Number.POSITIVE_INFINITY,tail:!0});if(n>=Ir)throw new Error(`no alignment record could be made out within ${Ir>>20} MB of byte ${e.toLocaleString("en-US")}`);n*=4}}remember(e,n=!1){let A=this.probes.length;for(;A>0&&this.probes[A-1].block>e.block;)A--;const s=this.probes[A-1];if(s!==void 0&&s.block===e.block&&s.within===e.within)return s;if(n)return this.probes.splice(A,0,e),e;const r=A===0?this.first:this.probes[A-1],o=A<this.probes.length?this.probes[A]:null;if(r!==null&&r.key>e.key)throw new NA(r,e);if(o!==null&&e.key>o.key)throw new NA(e,o);return this.probes.splice(A,0,e),e}async firstRecord(e){let n=Rf;for(;;){const A=await this.read(Math.min(n,this.size),0);let s=0,r=0;for(;s+Nn<=A.length;){const o=ye(A.subarray(s,Math.min(s+64,A.length)));if(o===null||s+o>A.length)break;const i=Si(A,s+o-4);if(e<r+i){const{bytes:a,blocks:c}=await kA(A.subarray(s),s),l=e-r;if(l+me>a.length){if(A.length>=this.size)return null;break}if(!MA(a,l,this.refs))throw new Error("the first alignment record is not where the header says it begins");const g=new DataView(a.buffer,a.byteOffset,a.byteLength);return bA(c,l,g.getInt32(l+4,!0),g.getInt32(l+8,!0))}r+=i,s+=o}if(A.length>=this.size)return null;if(n>=Lf)throw new Error("the header does not end within the first 16 MB");n*=4}}async read(e,n){const A=await this.handle.read(e,n);return this.bytesRead+=A.length,this.progress!==void 0&&this.progress(this.bytesRead),A}}async function kA(t,e){const n=[],A=[];let s=0,r=0,o=!1;for(;r+Nn<=t.length;){const c=ye(t.subarray(r,Math.min(r+64,t.length)));if(c===null||r+c>t.length)break;const l=await Yt(t.subarray(r,r+c),0);l.length===0&&(o=!0),A.push({fileAt:e+r,from:s,to:s+l.length}),n.push(l),s+=l.length,r+=c}const i=new Uint8Array(s);let a=0;for(const c of n)i.set(c,a),a+=c.length;return{bytes:i,blocks:A,sawEnd:o}}function bA(t,e,n,A){for(const r of t)if(e>=r.from&&e<r.to)return{block:r.fileAt,within:e-r.from,refId:n,pos:A,key:jt(n,A)};const s=t[t.length-1];return{block:s.fileAt,within:e-s.from,refId:n,pos:A,key:jt(n,A)}}function xf(t,e,n){for(let A=0;A+Nn<=t.length;A++){if(t[A]!==Pt[0]||t[A+1]!==Pt[1]||t[A+2]!==Pt[2]||t[A+3]!==Pt[3])continue;const s=ye(t.subarray(A,Math.min(A+64,t.length)));if(s===null||s>Et||s<Nn+8)continue;const r=A+s;if(r>t.length)return e+r===n?A:"more";if(!(Si(t,r-4)>Et)){if(e+r===n)return A;if(r+3<=t.length){if(t[r]===Pt[0]&&t[r+1]===Pt[1]&&t[r+2]===Pt[2])return A;continue}return"more"}}return"more"}async function vf(t,e,n,A){const s=xf(t,e,A);if(s==="more")return e+t.length>=A?{kind:"end"}:{kind:"more"};const{bytes:r,blocks:o,sawEnd:i}=await kA(t.subarray(s),e+s);if(r.length===0)return i||e+t.length>=A?{kind:"end"}:{kind:"more"};const a=Uf(r,n);if(a>=0){const c=new DataView(r.buffer,r.byteOffset,r.byteLength);return{kind:"record",placed:bA(o,a,c.getInt32(a+4,!0),c.getInt32(a+8,!0))}}return 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d=0,C=0;wn(t,e,p=>{if(d++,p.refId===n&&(p.flag&o.exclude)===0&&!(p.mapq<o.minMapq)&&!(p.pos<0||p.end<=A||p.pos>=s)){if(C++,Wf(t,p,(w,y)=>{const N=Math.max(w,A),k=Math.min(y,s);k<=N||Er(f,h,(N-A)/g,(k-A)/g,r)}),a!==void 0){let w=null;qf(t,p,(y,N)=>{if(N<=A||y>=s)return;w??=Hf(t,p);const k=`${y}:${N}:${w}`;a.set(k,(a.get(k)??0)+1)})}if(c!==void 0)for(const w of ni(t,p)){if(w.pos<A||w.pos>=s)continue;const y=zl(w.prob,c.threshold);if(y<0)continue;let N=c.tally.get(w.code);N===void 0&&(N={calls:new Float64Array(r),modified:new Float64Array(r)},c.tally.set(w.code,N));const k=Math.min(r-1,Math.floor((w.pos-A)/g));N.calls[k]++,y===1&&N.modified[k]++}i===void 0||u===null||I===null||_f(t,p,i,w=>{w<A||w>=s||Er(u,I,(w-A)/g,(w+1-A)/g,r)},[A,s])}});let B=0,Q=0;const E=new Float32Array(r);for(let p=0;p<r;p++){B+=h[p];const w=B+f[p];E[p]=w,w>Q&&(Q=w)}let m=null;if(u!==null&&I!==null){m=new Float32Array(r);let p=0;for(let w=0;w<r;w++)p+=I[w],m[w]=p+u[w]}return{depth:E,variant:m,total:d,kept:C,max:Q}}function _f(t,e,n,A,s=[Number.NEGATIVE_INFINITY,Number.POSITIVE_INFINITY]){const r=new DataView(t.buffer,t.byteOffset,t.byteLength),o=Pe(t,e),i=o===null?e.cigarOps:o.length,a=f=>o===null?r.getUint32(e.cigarAt+f*4,!0):o[f],c=n.start+n.bases.length;let l=e.pos,g=0;for(let f=0;f<i;f++){const h=a(f),u=h&15,I=h>>>4;if(u===2){const d=Math.max(0,s[0]-l),C=Math.min(I,s[1]-l);for(let B=d;B<C;B++)A(l+B);l+=I;continue}if(mt(u)&&Ot(u)){const d=Math.max(0,n.start-l,s[0]-l),C=Math.min(I,c-l,s[1]-l,e.seqLength-g);for(let B=d;B<C;B++){const Q=l+B-n.start,E=Ne[n.bases[Q]];if(E===4)continue;const m=Kf(t,e.seqAt,g+B);m!==4&&m!==E&&A(l+B)}l+=I,g+=I;continue}mt(u)&&(l+=I),Ot(u)&&(g+=I)}}function Kf(t,e,n){const A=t[e+(n>>1)],s=n%2===0?A>>4:A&15;return Ne[cs.charCodeAt(s)]}function Er(t,e,n,A,s){const r=Math.min(s-1,Math.max(0,Math.floor(n))),o=Math.min(s-1,Math.max(0,Math.ceil(A)-1));if(!(o<r)){if(r===o){t[r]+=Math.min(A,r+1)-Math.max(n,r);return}t[r]+=r+1-Math.max(n,r),t[o]+=Math.min(A,o+1)-o,o>r+1&&(e[r+1]+=1,e[o]-=1)}}function qf(t,e,n){const A=Pe(t,e),s=A===null?e.cigarOps:A.length,r=A===null?new DataView(t.buffer,t.byteOffset,t.byteLength):null;let o=e.pos;for(let i=0;i<s;i++){const a=r===null?A[i]:r.getUint32(e.cigarAt+i*4,!0),c=a&15,l=a>>>4;if(c===3){l>0&&n(o,o+l),o+=l;continue}mt(c)&&(o+=l)}}function Hf(t,e){let A=e.seqAt+(e.seqLength+1>>1)+e.seqLength;const s=e.at+e.bytes-4;for(;A+3<=s;){const r=t[A],o=t[A+1],i=String.fromCharCode(t[A+2]);if(A+=3,i==="A"&&(r===88&&o===83||r===116&&o===115)){const a=t[A]===43?1:t[A]===45?-1:0;return r===88?a:(e.flag&At.REVERSE)!==0?-a:a}if(A=as(t,A,i,s),A<0)return 0}return 0}function Wf(t,e,n){const A=new DataView(t.buffer,t.byteOffset,t.byteLength),s=Pe(t,e),r=s===null?e.cigarOps:s.length,o=l=>s===null?A.getUint32(e.cigarAt+l*4,!0):s[l];let i=e.pos,a=e.pos,c=!1;for(let l=0;l<r;l++){const g=o(l),f=g&15,h=g>>>4;if(f===3){c&&i>a&&n(a,i),c=!1,i+=h,a=i;continue}mt(f)&&(c||(a=i,c=!0),i+=h)}c&&i>a&&n(a,i)}function Pf(t,e,n){let A=2166136261;for(let s=e;s<n;s++)A^=t[s],A=Math.imul(A,16777619)>>>0;return A/4294967296}function zf(t,e,n,A,s,r,o){const i=new DataView(t.buffer,t.byteOffset,t.byteLength),a=o.filter;let c=0;const l=[];wn(t,e,C=>{mr(C,A,s,r,a)&&(c++,l.push(Pf(t,C.at+32,C.at+32+C.nameBytes-1)))});const g=Math.max(1,Math.min(o.maxReads,o.maxRows*Xf)),f=c<=g?1:g/c,h=f<1,u=[],I=[];let d=0;return wn(t,e,C=>{!mr(C,A,s,r,a)||l[d++]>=f||I.push(Vf(t,i,C,o,u))}),{pile:rh(I,n,A,s,r,o),total:c,kept:I.length,capped:h,rows:u.length,usedMd:I.some(C=>C.fromMd),usedCigar:I.some(C=>C.fromCigar)}}const Xf=8;function mr(t,e,n,A,s){return t.refId!==e||(t.flag&s.exclude)!==0||t.mapq<s.minMapq?!1:t.pos>=0&&t.end>n&&t.pos<A}function Vf(t,e,n,A,s){const r=Pe(t,n),o=r===null?n.cigarOps:r.length,i=h=>r===null?e.getUint32(n.cigarAt+h*4,!0):r[h],a=[];let c=0,l=0;for(let h=0;h<o;h++){const u=i(h);a.push(u);const I=u&15,d=u>>>4;I===4&&(h===0||h===1&&(i(0)&15)===5?c=d:(h===o-1||h===o-2&&(i(o-1)&15)===5)&&(l=d))}const g=th(t,n,a,A.reference),f=jf(s,n.pos-c,n.end+l);return{refStart:n.pos,refEnd:n.end,clipStart:c,clipEnd:l,row:f,flag:n.flag,mapq:n.mapq,mateContig:n.nextRefId,matePos:n.nextPos,tlen:n.tlen,name:xl(t,n),ops:a,diffPos:g.pos,diffBase:g.base,fromMd:g.fromMd,fromCigar:g.fromCigar,mods:A.colourBy==="basemod"?ni(t,n,a):null}}const Zf=3;function jf(t,e,n){for(let A=0;A<t.length;A++)if(t[A]+Zf<=e)return t[A]=n,A;return t.push(n),t.length-1}function FA(t,e,n){const A=t[e+(n>>1)],s=n%2===0?A>>4:A&15;return Ne[cs.charCodeAt(s)]}function th(t,e,n,A){const s={pos:[],base:[],fromMd:!1,fromCigar:!1};if(n.some(o=>(o&15)===8)){let o=e.pos,i=0;for(const a of n){const c=a&15,l=a>>>4;if(c===8){const g=Math.min(l,e.seqLength-i);for(let f=0;f<g;f++)s.pos.push(o+f),s.base.push(FA(t,e.seqAt,i+f))}mt(c)&&(o+=l),Ot(c)&&(i+=l)}return s.fromCigar=!0,s}const r=eh(t,e);if(r!==null)return nh(t,e,n,r,s),s.fromMd=!0,s;if(A!==void 0){let o=e.pos,i=0;const a=A.start+A.bases.length;for(const c of n){const l=c&15,g=c>>>4;if(mt(l)&&Ot(l)){const f=Math.max(0,A.start-o),h=Math.min(g,a-o,e.seqLength-i);for(let u=f;u<h;u++){const I=o+u-A.start,d=Ne[A.bases[I]],C=FA(t,e.seqAt,i+u);d!==C&&d<4&&C<4&&(s.pos.push(o+u),s.base.push(C))}}mt(l)&&(o+=g),Ot(l)&&(i+=g)}}return s}function eh(t,e){let A=e.seqAt+(e.seqLength+1>>1)+e.seqLength;const s=e.at+e.bytes-4;for(;A+3<=s;){const r=String.fromCharCode(t[A],t[A+1]),o=String.fromCharCode(t[A+2]);if(A+=3,r==="MD"&&o==="Z"){let i=A;for(;i<s&&t[i]!==0;)i++;return new TextDecoder().decode(t.subarray(A,i))}if(A=as(t,A,o,s),A<0)return null}return null}function nh(t,e,n,A,s){const r=[],o=[];let i=e.pos,a=0;for(const l of n){const g=l&15,f=l>>>4;if(mt(g)&&Ot(g)){const h=Math.min(f,e.seqLength-a);for(let u=0;u<h;u++)r.push(i+u),o.push(a+u)}mt(g)&&(i+=f),Ot(g)&&(a+=f)}let c=0;for(const l of A.match(/(\d+|\^[A-Za-z]+|[A-Za-z])/g)??[]){if(l.charCodeAt(0)===94)continue;const g=Number(l);if(Number.isFinite(g)&&l!==""){c+=g;continue}c<r.length&&(s.pos.push(r[c]),s.base.push(FA(t,e.seqAt,o[c]))),c+=1}}const Li=1e3;function Ah(t,e,n){switch(e){case"strand":return(t.flag&At.REVERSE)!==0?1:0;case"mapq":return t.mapq===0?0:t.mapq<30?1:2;case"pair":return(t.flag&At.PAIRED)===0?0:(t.flag&At.PROPER_PAIR)!==0?1:2;case"mate":return(t.flag&At.PAIRED)===0?0:(t.flag&At.MATE_UNMAPPED)!==0||t.mateContig<0?1:t.mateContig===n?2:3;case"insert":{const A=Math.abs(t.tlen);return(t.flag&At.PAIRED)===0||A===0?0:A>Li?2:1}default:return 0}}function sh(t){switch(t){case"strand":return["forward","reverse"];case"mapq":return["MAPQ 0","MAPQ < 30","MAPQ ≥ 30"];case"pair":return["unpaired","proper pair","not a proper pair"];case"mate":return["unpaired","mate unmapped","same sequence","another sequence"];case"insert":return["unpaired","ordinary insert",`insert > ${Li}`];case"basemod":return["reads"];default:return["reads"]}}function rh(t,e,n,A,s,r){const o=t.length,i={contig:e,start:A,end:s,length:o,refStart:new Int32Array(o),refEnd:new Int32Array(o),clipStart:new Int32Array(o),clipEnd:new Int32Array(o),row:new Int16Array(o),flags:new Uint16Array(o),mapq:new Uint8Array(o),mateContig:new Int32Array(o),matePos:new Int32Array(o),tlen:new Int32Array(o),group:new Uint8Array(o),mate:new Int32Array(o).fill(-1),opAt:new Int32Array(o+1),opCode:new Uint8Array(t.reduce((l,g)=>l+g.ops.length,0)),opLen:new Int32Array(t.reduce((l,g)=>l+g.ops.length,0)),diffAt:new Int32Array(o+1),diffPos:new Int32Array(t.reduce((l,g)=>l+g.diffPos.length,0)),diffBase:new Uint8Array(t.reduce((l,g)=>l+g.diffPos.length,0)),contigs:[],groups:sh(r.colourBy),names:[]};let a=0,c=0;for(let l=0;l<o;l++){const g=t[l];i.refStart[l]=g.refStart,i.refEnd[l]=g.refEnd,i.clipStart[l]=g.clipStart,i.clipEnd[l]=g.clipEnd,i.row[l]=g.row,i.flags[l]=g.flag,i.mapq[l]=g.mapq,i.mateContig[l]=g.mateContig,i.matePos[l]=g.matePos,i.tlen[l]=g.tlen,i.opAt[l]=a;for(const f of g.ops)i.opCode[a]=f&15,i.opLen[a]=f>>>4,a++;i.diffAt[l]=c;for(let f=0;f<g.diffPos.length;f++)i.diffPos[c]=g.diffPos[f],i.diffBase[c]=g.diffBase[f],c++;r.withNames&&i.names.push(g.name)}i.opAt[o]=a,i.diffAt[o]=c,r.colourBy==="basemod"&&(i.mods=oh(t));for(let l=0;l<o;l++)i.group[l]=Ah(t[l],r.colourBy,n);return ih(i,n,e,r),ah(i,t),i}function oh(t){const e=new Map;let n=0;for(const i of t)for(const a of i.mods??[]){const c=e.get(a.code)??[0,0];a.prob>=128&&c[0]++,c[1]++,e.set(a.code,c),n++}const A=[...e.entries()].sort((i,a)=>a[1][0]-i[1][0]||a[1][1]-i[1][1]||(i[0]<a[0]?-1:1)),s=new Map(A.map(([i],a)=>[i,a])),r={at:new Int32Array(t.length+1),pos:new Int32Array(n),code:new Uint8Array(n),prob:new Uint8Array(n),codes:A.map(([i])=>i),counts:A.map(([,[i]])=>i)};let o=0;for(let i=0;i<t.length;i++){r.at[i]=o;for(const a of t[i].mods??[])r.pos[o]=a.pos,r.code[o]=s.get(a.code)??0,r.prob[o]=a.prob,o++}return r.at[t.length]=o,r}function ih(t,e,n,A){const s=new Map;for(let r=0;r<t.length;r++){const o=t.mateContig[r];if(o<0){t.mateContig[r]=-1;continue}let i=s.get(o);i===void 0&&(i=t.contigs.length,t.contigs.push(o===e?n:A.refNameOf?.(o)??""),s.set(o,i)),t.mateContig[r]=i}}function ah(t,e){const n=new Map;for(let A=0;A<e.length;A++){const s=e[A].name;if(s===""||(t.flags[A]&At.SUPPLEMENTARY)!==0)continue;const r=n.get(s);if(r===void 0){n.set(s,A);continue}t.mate[r]===-1&&t.mate[A]===-1&&((t.flags[r]^t.flags[A])&(At.FIRST_IN_PAIR|At.SECOND_IN_PAIR))!==0&&(t.mate[r]=A,t.mate[A]=r)}}function Gi(t){const e=t.split(`
+`,200);let n=0;for(const A of e){const s=A.trim();if(s==="")continue;if(/^(fixedStep|variableStep)\b/i.test(s))return"wig";if(/^track\b/i.test(s)){if(/type\s*=\s*"?bedGraph/i.test(s))return"bedgraph";if(/type\s*=\s*"?wiggle_0/i.test(s))return"wig";continue}if(s.startsWith("#")||/^browser\b/i.test(s))continue;const r=s.split(/\t| +/);if(r.length!==4||!R(r[1])||!R(r[2]))return null;const o=Number(r[3]);if(!Number.isFinite(o)||r[3].trim()==="")return null;if(n+=1,n>=4)return"bedgraph"}return n>0?"bedgraph":null}class Qs{constructor(e){this.name=e}starts=[];ends=[];values=[];push(e,n,A){this.starts.push(e),this.ends.push(n),this.values.push(A)}get length(){return this.starts.length}finish(){const e=this.starts.length,n=Int32Array.from({length:e},(i,a)=>a);let A=!0;for(let i=1;i<e;i++)if(this.starts[i]<this.starts[i-1]){A=!1;break}A||n.sort((i,a)=>this.starts[i]-this.starts[a]);const s=new Int32Array(e),r=new Int32Array(e),o=new Float32Array(e);for(let i=0;i<e;i++){const a=n[i];s[i]=this.starts[a],r[i]=this.ends[a],o[i]=this.values[a]}return{name:this.name,starts:s,ends:r,values:o}}}function xi(t){const e=new Map;let n=Number.POSITIVE_INFINITY,A=Number.NEGATIVE_INFINITY,s=0;for(const r of t.split(`
+`)){const o=r.trim();if(o===""||o.startsWith("#")||/^(track|browser)\b/i.test(o))continue;const i=o.split(/\t| +/);if(i.length<4)continue;const a=Number(i[1]),c=Number(i[2]),l=Number(i[3]);if(!Number.isInteger(a)||!Number.isInteger(c)||!Number.isFinite(l)||c<=a)continue;let g=e.get(i[0]);g===void 0&&(g=new Qs(i[0]),e.set(i[0],g)),g.push(a,c,l),s+=1,l<n&&(n=l),l>A&&(A=l)}return Bs(e,s,n,A)}function vi(t){const e=new Map;let n=Number.POSITIVE_INFINITY,A=Number.NEGATIVE_INFINITY,s=0,r=null,o="",i=1,a=1,c=0,l=null;const g=(f,h)=>{l===null||!Number.isFinite(h)||(l.push(f,f+i,h),s+=1,h<n&&(n=h),h>A&&(A=h))};for(const f of t.split(`
+`)){const h=f.trim();if(h===""||h.startsWith("#")||/^(track|browser)\b/i.test(h))continue;const u=/^(fixedStep|variableStep)\s+(.*)$/i.exec(h);if(u!==null){r=u[1].toLowerCase()==="fixedstep"?"fixed":"variable";const I=new Map;for(const d of u[2].split(/\s+/)){const C=d.indexOf("=");C>0&&I.set(d.slice(0,C).toLowerCase(),d.slice(C+1))}if(o=I.get("chrom")??"",i=Number(I.get("span")??1)||1,a=Number(I.get("step")??1)||1,c=(Number(I.get("start")??1)||1)-1,o===""){l=null;continue}l=e.get(o)??new Qs(o),e.set(o,l);continue}if(!(r===null||l===null))if(r==="fixed")g(c,Number(h)),c+=a;else{const I=h.split(/\t| +/);if(I.length<2)continue;const d=Number(I[0]);if(!Number.isInteger(d))continue;g(d-1,Number(I[1]))}}return Bs(e,s,n,A)}function Bs(t,e,n,A){const s=[];for(const r of t.values())r.length>0&&s.push(r.finish());return{contigs:s,length:e,min:Number.isFinite(n)?n:0,max:Number.isFinite(A)?A:0}}class Ui{constructor(e){this.set=e;for(const n of e.contigs)this.byName.set(n.name,n)}byName=new Map;held(e){const n=this.byName.get(e);if(n!==void 0)return n;const A=Kt(this.set.contigs,e);return A<0?void 0:this.set.contigs[A]}get contigNames(){return this.set.contigs.map(e=>e.name)}get extent(){return{min:this.set.min,max:this.set.max}}get length(){return this.set.length}has(e){return this.held(e)!==void 0}samples(e,n,A,s){const r=this.held(e);if(r===void 0||A<=n)return null;const o=ch(r.ends,n);let i=o;for(;i<r.starts.length&&r.starts[i]<A;)i+=1;if(i<=o)return{starts:new Int32Array(0),ends:new Int32Array(0),values:new Float32Array(0),min:null,max:null,summary:!1};const a=Math.max(1,s),c=Math.ceil((A-n)/a);if(i-o<=c)return{starts:r.starts.slice(o,i),ends:r.ends.slice(o,i),values:r.values.slice(o,i),min:null,max:null,summary:!1};const l=new Int32Array(c),g=new Int32Array(c),f=new Float32Array(c),h=new Float32Array(c),u=new Float32Array(c),I=new Float64Array(c),d=new Float64Array(c);h.fill(Number.NaN),u.fill(Number.NaN);for(let C=0;C<c;C++)l[C]=Math.round(n+C*a),g[C]=Math.round(Math.min(A,n+(C+1)*a));for(let C=o;C<i;C++){const B=Math.max(r.starts[C],n),Q=Math.min(r.ends[C],A);if(Q<=B)continue;const E=r.values[C],m=Math.max(0,Math.floor((B-n)/a)),p=Math.min(c-1,Math.floor((Q-1-n)/a));for(let w=m;w<=p;w++){const y=Math.min(Q,g[w])-Math.max(B,l[w]);y<=0||(d[w]+=E*y,I[w]+=y,(Number.isNaN(h[w])||E<h[w])&&(h[w]=E),(Number.isNaN(u[w])||E>u[w])&&(u[w]=E))}}for(let C=0;C<c;C++)f[C]=I[C]>0?d[C]/I[C]:Number.NaN;return{starts:l,ends:g,values:f,min:h,max:u,summary:!0}}}function ch(t,e){let n=0,A=t.length;for(;n<A;){const s=n+A>>1;t[s]<=e?n=s+1:A=s}return n}const lh=1<<18,gh=64<<20;class wr extends Fo{constructor(e,n,A=lh,s=gh){super(e,n),this.chunkBytes=A,this.budgetBytes=s}chunks=new Map;inflight=new Map;held=0;end=null;fetched=0;requests=0;async read(e,n,A){if(e<=0||this.end!==null&&n>=this.end)return new Uint8Array(0);const s=Math.floor(n/this.chunkBytes),r=Math.floor((n+e-1)/this.chunkBytes),o=[];let i=null;const 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C=Math.max(g.start,f.starts[I]),B=Math.min(g.end,f.ends[I]);B<=C||(h+=d*(B-C),u+=B-C)}s.push({contig:g.contig,start:g.start,end:g.end,name:n.name[o[l]]??"",signal:h,mean:u>0?h/u:Number.NaN})}}return s}function Yh(t,e){return{contig:t.contigs[t.contig[e]],start:t.start[e],end:t.end[e]}}function Mn(t){return`${t.contig}:${t.start}-${t.end}`}function _h(t){return .5*Kh(-t/Math.SQRT2)}function Kh(t){const e=Math.abs(t),n=e<2?1-qh(e):Hh(e);return t>=0?n:2-n}function qh(t){let e=t,n=t;for(let A=1;A<200&&(e*=2*t*t/(2*A+1),n+=e,!(e<Math.abs(n)*1e-17));A++);return 2/Math.sqrt(Math.PI)*Math.exp(-t*t)*n}function Hh(t){let n=1/t,A=1e300,s=n;for(let r=1;r<300;r++){const o=r/2;n=t+o*n,n===0&&(n=1e-300),A=t+o/A,A===0&&(A=1e-300),n=1/n;const i=A*n;if(s*=i,Math.abs(i-1)<1e-16)break}return Math.exp(-t*t)/Math.sqrt(Math.PI)*s}function Wh(t){const e=t.length,n=new Float64Array(e).fill(Number.NaN),A=[];for(let o=0;o<e;o++)Number.isFinite(t[o])&&A.push(o);A.sort((o,i)=>t[i]-t[o]);const s=A.length;let 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h=0;h<g.length;h++)f+=o[r+h];a+=f*f/g.length,r+=g.length}a=12/(A*(A+1))*a-3*(A+1);const c=1-i/(A*A*A-A);if(!(c>0))return{h:Number.NaN,df:n-1,p:Number.NaN};const l=a/c;return{h:l,df:n-1,p:Vh(l,n-1)}}function Vh(t,e){return!(e>0)||Number.isNaN(t)?Number.NaN:t<=0?1:Zh(e/2,t/2)}function Zh(t,e){const n=Math.exp(-e+t*Math.log(e)-Wi(t));if(e<t+1){let a=1/t,c=a;for(let l=1;l<1e3&&(a*=e/(t+l),c+=a,!(Math.abs(a)<Math.abs(c)*1e-16));l++);return Math.max(0,1-c*n)}const A=1e-300;let s=e+1-t,r=1/A,o=1/s,i=o;for(let a=1;a<1e3;a++){const c=-a*(a-t);s+=2,o=c*o+s,Math.abs(o)<A&&(o=A),r=s+c/r,Math.abs(r)<A&&(r=A),o=1/o;const l=o*r;if(i*=l,Math.abs(l-1)<1e-16)break}return Math.min(1,n*i)}function Wi(t){if(t<.5)return Math.log(Math.PI/Math.sin(Math.PI*t))-Wi(1-t);const e=[.9999999999998099,676.5203681218851,-1259.1392167224028,771.3234287776531,-176.6150291621406,12.507343278686905,-.13857109526572012,9984369578019572e-21,15056327351493116e-23],n=t-1;let A=e[0];const s=n+7.5;for(let r=1;r<9;r++)A+=e[r]/(n+r);return .5*Math.log(2*Math.PI)+(n+.5)*Math.log(s)-s+Math.log(A)}const jh=1e4;function tu(t){return t.end-t.start+(t.wrap??0)}const Dn=["#0072b2","#d55e00","#009e73","#cc79a7","#e69f00","#56b4e9","#f0e442","#000000"],eu="#999999",br="rest of the genome",ue=2e4,nu=async t=>{const e=On(t.params,"tracks");if(e.length===0)return t.note("No track was chosen. Load a bigWig, or run a task that makes one, and tick it under Tracks."),[];const n=[];for(const[Q,E]of Object.entries(t.inputs.contigLengths??{}))E>0&&n.push({name:Q,length:E});if(n.length===0)return t.note("This session knows no sequence lengths, so there is no genome to cut into stretches. Load a chrom.sizes, or the map itself."),[];const A=T(t.params,"resolution",0),s=!(A>0),r=A>0?Math.round(A):t.framing.binsize>0&&!qi(t.framing)?t.framing.binsize:jh,o=new Set(t.framing.circular??[]);let i=st(t.params,"groupBy","features")==="track"?await su(t,n,r,s,o):Au(t,n,s?Number.POSITIVE_INFINITY:r,o);if(i===null)return[];const a=s?{one:"entry"}:{one:"stretch"};if(i=ru(i,t,a.one),i.stretches.length===0)return t.note(`No ${a.one} of the genome fell in any group, so there is nothing to compare.`),[];const c=Q=>t.inputs.labels?.[Q]??Q,l=i.names.length,g=[],f=[],h=[];for(let Q=0;Q<e.length;Q++){t.throwIfCancelled();const E=c(e[Q]);t.progress(Q,e.length,E);const m=await ps(t,e[Q],i.stretches),p=i.names.map(()=>[]);for(let k=0;k<i.stretches.length;k++)Number.isFinite(m[k])&&p[i.stretches[k].group].push(m[k]);if(p.every(k=>k.length===0)){t.note(`${E} has no value over any stretch — its sequence names may not be the assembly's.`);continue}let w=0,y=0;for(const k of p){for(const b of k)y+=b;w+=k.length}for(let k=0;k<l;k++){const b=Ph(p[k]),M=w-b.n,F=M>0?(y-b.mean*b.n)/M:Number.NaN;let S=0;for(const v of i.stretches)v.group===k&&(S+=tu(v));g.push({track:E,group:i.names[k],n:b.n,bases:S,mean:b.mean,sd:b.sd,median:b.median,q1:b.q1,q3:b.q3,vsRest:b.n>0?b.mean-F:Number.NaN})}const N=p.map((k,b)=>({group:k,g:b})).filter(k=>k.group.length>0);if(N.length>2){const k=Xh(N.map(b=>b.group));f.push({track:E,test:"Kruskal–Wallis H",a:`all ${N.length} groups`,b:"",statistic:k.h,effect:Number.NaN,difference:Number.NaN,p:k.p})}for(let k=0;k<N.length;k++)for(let b=k+1;b<N.length;b++){const M=N[k],F=N[b],S=zh(M.group,F.group);f.push({track:E,test:"Mann–Whitney U",a:i.names[M.g],b:i.names[F.g],statistic:S.u,effect:S.effect,difference:Te(Ae(M.group),.5)-Te(Ae(F.group),.5),p:S.p})}h.push({kind:"curve",id:`groupsignal-${Q+1}`,label:`${E} by ${i.of}`,series:p.map((k,b)=>{const M=cu(k);return{name:i.names[b],x:Float64Array.from(M,(F,S)=>S),y:M,colour:i.colours[b],n:k.length,mark:"violin"}}),xLabel:i.of,yLabel:E,xScale:"linear",yScale:"linear"})}if(t.progress(e.length,e.length,"done"),h.length===0)return[];const u=Wh(f.map(Q=>Number(Q.p)));f.forEach((Q,E)=>{Q.q=u[E]});const I=h.some(Q=>Q.series.some(E=>(E.n??0)>ue)),d=i.stretches.length.toLocaleString(),C=s?i.segments!==void 0?`${d} entries, each a run of ${r.toLocaleString()} bp bins in one group,`:`${d} entries, each a run of features under one name or a stretch between them,`:`${d} stretches of at most ${r.toLocaleString()} bp`;t.note(`Compared over ${C} in ${l} groups, each the track's mean over the bases it has a value for.${I?` A violin of more than ${ue.toLocaleString()} is drawn from that many, evenly by rank; the tests use every one.`:""}`);const B=[...h];if(B.push({kind:"table",id:"groupsignal-groups",label:`Groups · ${i.of}`,columns:[{key:"track",label:"Track",kind:"text"},{key:"group",label:"Group",kind:"text"},{key:"n",label:s?"Entries":"Stretches",kind:"number"},{key:"bases",label:"Bases",kind:"number"},{key:"mean",label:"Mean",kind:"number",digits:4},{key:"sd",label:"SD",kind:"number",digits:4},{key:"median",label:"Median",kind:"number",digits:4},{key:"q1",label:"Q1",kind:"number",digits:4},{key:"q3",label:"Q3",kind:"number",digits:4},{key:"vsRest",label:"Mean − rest",kind:"number",digits:4,hint:"This group’s mean less that of every other stretch."}],rows:g}),B.push({kind:"table",id:"groupsignal-tests",label:"Between groups",columns:[{key:"track",label:"Track",kind:"text"},{key:"test",label:"Test",kind:"text"},{key:"a",label:"Group",kind:"text"},{key:"b",label:"Against",kind:"text"},{key:"difference",label:"Median difference",kind:"number",digits:4},{key:"effect",label:"Effect",kind:"number",digits:3,hint:"Rank-biserial r: +1 where every value of the group is above every value against it."},{key:"statistic",label:"U or H",kind:"number",digits:2},{key:"p",label:"P",kind:"number",digits:4,scientific:!0},{key:"q",label:"q",kind:"number",digits:4,scientific:!0,hint:"Benjamini–Hochberg, over every test of the run."}],rows:f}),i.segments!==void 0&&B.push({kind:"intervals",id:"groupsignal-segments",label:`Groups · ${i.of}`,payload:{kind:"features",data:i.segments},noun:{one:"segment",many:"segments"},display:"lane",look:"corner"}),st(t.params,"groupBy","features")!=="track"&&Lt(t.params,"perFeature",!1)){const Q=await au(t,e,c);Q!==null&&B.push(Q)}return B};function Au(t,e,n,A){const s=ne(t.inputs.features,t.params,"features"),r={chosen:s.chosen,value:s.chosen?s.value:void 0},o=r.value;if(o===void 0)return t.note(_n(r,{unchosen:"No feature set was chosen to make the groups from.",gone:"The feature set chosen is no longer loaded. 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m=0;m<o.contigs.length;m++){const p=o.contigs[m],w=I(p);if(w===void 0){o.contigAt[m+1]>o.contigAt[m]&&C.add(p);continue}const y=h.map(()=>[]);for(let N=o.contigAt[m];N<o.contigAt[m+1];N++){const k=c[N];if(k===null)continue;const b=Math.max(0,o.start[N]),M=Math.min(w,o.end[N]);M>b&&y[u.get(k)??0].push([b,M])}d.set(p,y.map(Mr))}C.size>0&&t.note(`${[...C].slice(0,6).join(", ")}${C.size>6?", …":""} ${C.size===1?"is":"are"} not a sequence of this assembly, so ${C.size===1?"its":"their"} features were left out.`);const B=[],Q=new Map;for(const[m,p]of d)p.forEach((w,y)=>{for(const[N,k]of w)for(const[b,M]of oA(N,k,n))B.push({contig:m,start:b,end:M,group:y})}),Q.set(m,Mr(p.flat()));if(f){const m=h.length-1;for(const{name:p,length:w}of e){let y=0;for(const[N,k]of Q.get(p)??[]){for(const[b,M]of oA(y,N,n))B.push({contig:p,start:b,end:M,group:m});y=Math.max(y,k)}for(const[N,k]of oA(y,w,n))B.push({contig:p,start:N,end:k,group:m})}}const E=i==="score"?"score":i==="strand"?"strand":i==="none"?"":"name";return{names:h,colours:h.map((m,p)=>m===br?eu:Dn[p%Dn.length]),stretches:n===Number.POSITIVE_INFINITY?Vi(B,e,A):B,of:E===""?a:`${a}, by ${E}`}}async function su(t,e,n,A,s){const r=at(t.params,"groupTrack");if(r===null)return t.note("No track was chosen to group the bins by."),null;const o=t.inputs.labels?.[r]??r,i=[];for(const d of e)for(let C=0;C<d.length;C+=n)i.push({contig:d.name,start:C,end:Math.min(d.length,C+n),group:-1});const a=await ps(t,r,i),c=st(t.params,"cut","sign")==="quantiles"?"quantiles":"sign";let l;if(c==="sign"){l=["above 0","below 0"];for(let d=0;d<i.length;d++)i[d].group=a[d]>0?0:a[d]<0?1:-1}else{const d=Pi(t),C=Ki(a,d);if(C.length===0)return t.note(`${o} has no value over any bin, so there is nothing to cut into quantiles.`),null;l=Array.from({length:d},(B,Q)=>zi(Q,C));for(let B=0;B<i.length;B++)i[B].group=Xi(a[B],C)}const g=i.filter(d=>d.group>=0);g.length<i.length&&t.note(`${(i.length-g.length).toLocaleString()} of ${i.length.toLocaleString()} bins had no reading of ${o}${c==="sign"?", or read exactly 0,":""} and are in no group.`);const f=new et,h=[];let u=null;const I=()=>{u!==null&&(f.add(u.contig,u.start,u.end,{name:l[u.group]}),h.push(u)),u=null};for(const d of g){if(u!==null&&u.contig===d.contig&&u.group===d.group&&u.end===d.start){u.end=d.end;continue}I(),u={...d}}return I(),{names:l,colours:l.map((d,C)=>Dn[C%Dn.length]),stretches:A?Vi(h,e,s):g,of:`${o}, ${c==="sign"?"by sign":"in quantiles"}`,segments:f.finish()}}function ru(t,e,n){const A=new Array(t.names.length).fill(0);for(const i of t.stretches)A[i.group]++;if(A.every(i=>i>0))return t;const s=t.names.filter((i,a)=>A[a]===0);e.note(`${s.join(", ")} had no ${n} in ${s.length===1?"it":"them"}, and ${s.length===1?"is":"are"} left out.`);const r=t.names.map((i,a)=>a).filter(i=>A[i]>0),o=new 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n=[...t].sort((r,o)=>Number.isNaN(r.rank)?Number.isNaN(o.rank)?0:1:Number.isNaN(o.rank)?-1:o.rank-r.rank);if(e.subset==="top")return[{name:`top ${e.count}`,features:n.slice(0,e.count)}];if(e.subset==="bottom")return[{name:`bottom ${e.count}`,features:n.slice(-e.count)}];const A=[],s=Math.ceil(n.length/e.groups);for(let r=0;r<e.groups;r++){const o=n.slice(r*s,(r+1)*s);o.length!==0&&A.push({name:`group ${r+1}`,features:o})}return A}const wu=async t=>{const e=On(t.params,"tracks"),n=ne(t.inputs.features,t.params,"features"),A=n.value;if(e.length===0||A===void 0){const b=_n(n,{unchosen:"No feature set was chosen. Load a BED or a GTF and pick it under Features.",gone:"The feature set chosen is no longer loaded. Re-open the file, or pick another."});return t.note(e.length===0&&b!==null?"A metaplot needs a track to read and a set of positions to read it at, and neither is in hand.":e.length===0?"No track was chosen. 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Check that the track and the set share an assembly."),[];I>0&&t.note(`${I.toLocaleString()} features were dropped: shorter than the body width, or with no window left after clipping to the sequence.`);const y=LA(B);C.push({kind:"curve",id:"metaplot",label:"Metaplot",series:d,xLabel:y.label,...y.scaled===void 0?{}:{xScaled:y.scaled},yLabel:a?"Signal (z-score, per track)":"Mean signal",xScale:"linear",yScale:"linear"});const N=E.length===0?[]:m.map(Du),k={zscore:a,tracks:e.length};return E.forEach((b,M)=>{C.push(Fu(b,N[b.group],M,B,y.label,k))}),C},pu=1<<20,yu=4096;async function Nu(t,e,n,A){const s=new Float64Array(n.length*A.slots).fill(Number.NaN),r=new Map;for(let o=0;o<n.length;o++){const i=r.get(n[o].contig);i===void 0?r.set(n[o].contig,[o]):i.push(o)}for(const[o,i]of r){const a=new Map;for(const g of i){const f=`${n[g].start}-${n[g].end}`,h=a.get(f);h===void 0?a.set(f,[g]):h.push(g)}const c=[...a.keys()].map(g=>{const[f,h]=g.split("-").map(Number);return{contig:o,start:f,end:h}}).sort((g,f)=>g.start-f.start||g.end-f.end),l=new Map;for(let g=0;g<c.length;){t.throwIfCancelled();let f=g+1,h=c[g].end-c[g].start;for(;f<c.length&&f-g<yu&&(h+=c[f].end-c[f].start,!(h>pu));)f++;const u=await t.sample(e,c.slice(g,f),1);g=f;for(const I of u.regions)for(const d of a.get(`${I.start}-${I.end}`)??[]){const C=n[d],{body:B,span:Q}=C,E=`${C.start}-${C.end}:${C.strand}:${C.slotFrom}-${C.slotTo}`+(Q===void 0?"":`:${Q.start}-${Q.end}`)+(B===void 0?"":`:${B.start}-${B.end}:${B.slotFrom}-${B.slotTo}`),m=l.get(E);if(m!==void 0){s.copyWithin(d*A.slots,m*A.slots,(m+1)*A.slots);continue}l.set(E,d),s.set(fu(I,C,A.slots),d*A.slots)}}}return s}function ku(t){const e=Math.max(1,Math.floor(t.length/1e5)),n=[];for(let i=0;i<t.length;i+=e){const a=t[i];Number.isFinite(a)&&n.push(a)}if(n.length===0)return null;n.sort((i,a)=>i-a);const A=i=>n[Math.min(n.length-1,Math.floor(i*(n.length-1)))],s=A(.99),r=n[0]>=0?0:-Math.max(Math.abs(A(.01)),Math.abs(s)),o=n[0]>=0?s:Math.max(Math.abs(A(.01)),Math.abs(s));return o>r?[r,o]:null}function bu(t){const{x:e,scaled:n}=LA(t);if(e.length===0)return{labels:[]};if(n!==void 0){const o=[n.start,n.end];n.start>n.from&&o.push(n.from),n.to>n.end&&o.push(n.to),o.push((n.start+n.end)/2);const i=n.to-n.from;return{labels:o.map(a=>Qu(n,a)),at:o.map(a=>(a-n.from)/i)}}const A=t.flankStep>0?t.flankStep:1,s=e[0]-A/2,r=e[e.length-1]+A/2;return{labels:[0,.25,.5,.75,1].map(o=>{const i=s+o*(r-s);return Math.abs(i)>=1e4?`${Number((i/1e3).toFixed(1))} kb`:String(Math.round(i))})}}function Mu(t,e,n,A){for(let s=0;s<n;s++){let r=0,o=0;for(let i=0;i<A;i++){const a=e[s*A+i];Number.isFinite(a)&&(r+=a,o++)}t.total[s]+=r,t.seen[s]+=o}}function Du(t){const e=t.total.length,n=new Float64Array(e);for(let A=0;A<e;A++)n[A]=t.seen[A]===0?Number.NaN:t.total[A]/t.seen[A];return Array.from({length:e},(A,s)=>s).sort((A,s)=>Number.isNaN(n[A])?Number.isNaN(n[s])?0:1:Number.isNaN(n[s])?-1:n[s]-n[A])}function Fu(t,e,n,A,s,r){const{rows:o,count:i}=t,a=new Float32Array(i*A.slots);for(let g=0;g<i;g++)a.set(o.subarray(e[g]*A.slots,(e[g]+1)*A.slots),g*A.slots);const c=ku(a),l=bu(A);return{kind:"matrix",id:n===0?"metaplot-heatmap":`metaplot-heatmap-${n+1}`,label:`${t.name} · per feature${r.zscore?", z-scored":""}`,nrows:i,ncols:A.slots,values:a,xLabel:s,yLabel:r.tracks===1?`Features, strongest first (${i.toLocaleString()})`:`Features, strongest first across ${r.tracks} tracks (${i.toLocaleString()})`,xTicks:l.labels,...l.at===void 0?{}:{xTickAt:l.at},yTicks:[],colormap:"viridis",...c===null?{}:{range:c},aspect:"fill"}}const Nt=1,kt=2,bt=4,dt=8,Su=Nt|kt|bt|dt,ta=(()=>{const t=new Uint8Array(256),e={A:Nt,C:kt,G:bt,T:dt,U:dt,R:Nt|bt,Y:kt|dt,S:bt|kt,W:Nt|dt,K:bt|dt,M:Nt|kt,B:kt|bt|dt,D:Nt|bt|dt,H:Nt|kt|dt,V:Nt|kt|bt,N:Su};for(const[n,A]of Object.entries(e))t[n.charCodeAt(0)]=A,t[n.toLowerCase().charCodeAt(0)]=A;return t})(),Ru=(()=>{const t=new Uint8Array(16);for(let e=0;e<16;e++){let n=0;(e&Nt)!==0&&(n|=dt),(e&kt)!==0&&(n|=bt),(e&bt)!==0&&(n|=kt),(e&dt)!==0&&(n|=Nt),t[e]=n}return t})();function Oe(t){return!(t instanceof Uint8Array)}const Rr=200;function Ye(t){const e=t.replace(/\s+/g,"");if(e==="")return{reason:"Type a sequence to search for."};if(e.length>Rr)return{reason:`${e.length} bases is longer than this searches for (${Rr}). It looks for short motifs, so a query that long is a job for an aligner.`};const n=new Uint8Array(e.length);for(let A=0;A<e.length;A++){const s=ta[e.charCodeAt(A)]??0;if(s===0)return{reason:`“${e[A]}” is not a IUPAC base. Use A C G T U and the ambiguity codes R Y S W K M B D H V N.`};n[A]=s}return n}function ea(t){const e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)e[n]=Ru[t[t.length-1-n]??0]??0;return e}function Lu(t){const e=ea(t);for(let n=0;n<t.length;n++)if(t[n]!==e[n])return!1;return!0}function Lr(t,e,n,A){let s=0;for(let r=0;r<e.length;r++){const o=ta[t[n+r]??0]??0,i=e[r]??0;if((o===0||(o&~i)!==0)&&(s++,s>A))return s}return s}function ys(t,e,n={}){const A=[];if(e.length===0||t.length<e.length)return{hits:A,truncated:!1};const s=n.offset??0,r=n.limit??Number.POSITIVE_INFINITY,o=Math.max(0,Math.min(e.length-1,Math.floor(n.mismatches??0))),i=n.bothStrands===!0,a=i&&Lu(e),c=i&&!a?ea(e):null,l=a?0:1,g=t.length-e.length;for(let f=0;f<=g;f++){const h=Lr(t,e,f,o);if(h<=o&&(A.push({start:f+s,end:f+e.length+s,strand:l,mismatches:h}),A.length>=r))return{hits:A,truncated:f<g};if(c!==null){const u=Lr(t,c,f,o);if(u<=o&&(A.push({start:f+s,end:f+e.length+s,strand:-1,mismatches:u}),A.length>=r))return{hits:A,truncated:f<g}}}return{hits:A,truncated:!1}}function Gu(t){return Math.max(0,t.length-1)}function xu(t){return t>0?"+":t<0?"−":"±"}function vu(t,e){const n=new et,A=e.replace(/\s+/g,"").toUpperCase();for(const s of t.hits)for(let r=0;r<s.starts.length;r++){const o=s.strands[r],i=s.mismatches?.[r];n.add(s.contig,s.starts[r],s.ends[r],{strand:o,name:`${A} ${xu(o)}`,...i===void 0?{}:{score:i,detail:`${i} ${i===1?"mismatch":"mismatches"}`}})}return n.finish()}function na(t,e,n){const A=[];let s=0;for(const i of e){const a=Math.max(1,Math.ceil(i.length/n));A.push({name:i.name,startBin:s,bins:a,length:i.length}),s+=a}const r=new Float32Array(s),o=new Map(A.map(i=>[i.name,i]));for(const i of t.hits){const a=o.get(i.contig);if(a!==void 0)for(let c=0;c<i.starts.length;c++){const l=Math.min(a.bins-1,Math.floor(i.starts[c]/n));r[a.startBin+l]+=1}}return{binsize:n,firstBin:0,values:r,contigs:A}}function Uu(t,e,n=0){const A=t.replace(/\s+/g,"").toUpperCase(),s=[...e?["both strands"]:[],...n>0?[`≤ ${n} ${n===1?"mismatch":"mismatches"}`]:[]];return s.length===0?A:`${A} (${s.join(", ")})`}const un=5e5,Tu=16e6;function $u(t){const e=t.pattern;return typeof e=="string"?e.replace(/\s+/g,"").toUpperCase():""}async function Ju(t,e,n){const A=Math.max(1,Math.min(n.limit,un)),s=n.mismatches??0,r=n.contigs??t.contigs,o=Gu(e),i=t.read?.bind(t),a=Math.max(1,Math.floor(n.piece??Tu)),c=[];let l=0,g=!1;const f=r.reduce((u,I)=>u+I.length,0);let h=0;for(const u of r){if(l>=A){g=!0;break}const I=[];let d=!1;const C=(w,y)=>{const N=A-l-I.length,k=ys(w,e,{bothStrands:n.bothStrands,limit:N+1,mismatches:s,offset:y});for(let b=0;b<Math.min(k.hits.length,N);b++)I.push(k.hits[b]);(k.truncated||k.hits.length>N)&&(d=!0)};if(i===void 0){const w=t.bases(u.name);if(w===void 0)continue;C(w,0),h+=u.length,n.progress?.(h,f,u.name)}else for(let w=0;w<u.length&&!d;w+=a){n.throwIfCancelled?.();const y=Math.min(u.length,w+a),N=await i(u.name,w,Math.min(u.length,y+o));if(N===void 0)break;C(N,w),h+=y-w,n.progress?.(h,f,u.name)}d&&(g=!0);const B=I.length;if(B===0){if(d)break;continue}const Q=new Int32Array(B),E=new Int32Array(B),m=new Int8Array(B),p=s>0?new Uint8Array(B):void 0;for(let w=0;w<B;w++){const y=I[w];Q[w]=y.start,E[w]=y.end,m[w]=y.strand,p!==void 0&&(p[w]=y.mismatches)}if(c.push({contig:u.name,starts:Q,ends:E,strands:m,...p===void 0?{}:{mismatches:p}}),l+=B,d)break}return{hits:c,total:l,truncated:g}}function Aa(t,e,n){if(e===null)return[...t.contigs];const A=new Set(e);if(n.length>0&&n.every(r=>A.has(r)))return[...t.contigs];const s=new Set;for(const r of e){const o=Kt(t.contigs,r);o>=0&&s.add(o)}return t.contigs.filter((r,o)=>s.has(o))}const Ou=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to search."),[];if(e===null)return t.note("No reference was chosen. Load a FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.read===void 0&&n.refusal!==void 0)return t.note(n.refusal),[];const A=Yn(t.params,"sequences");if(A!==null&&A.length===0)return t.note("No sequence is ticked, so there is nothing to search."),[];const s=Object.entries(t.inputs.contigLengths??{}).filter(([,B])=>B>0).map(([B])=>B),r=Aa(n,A,s);if(r.length===0)return t.note("None of the ticked sequences is in this reference, so there is nothing to search."),[];const o=r.length===n.contigs.length,i=$u(t.params),a=Ye(i);if(Oe(a))return t.note(a.reason),[];const c=Lt(t.params,"bothStrands",!0),l=Math.min(un,Math.max(1,Math.round(T(t.params,"limit",un)))),g=Math.max(0,Math.min(a.length-1,Math.round(T(t.params,"mismatches",0))));t.progress(0,1,r.length===1?`searching ${r[0].name}`:`searching ${r.length.toLocaleString()} sequences`);const f=await Ju(n,a,{bothStrands:c,limit:l,mismatches:g,contigs:r,...n.read===void 0?{}:{progress:(B,Q,E)=>t.progress(B,Q,`searching ${E}`),throwIfCancelled:()=>t.throwIfCancelled()}});t.progress(1,1,"done");const h=Yu(Uu(i,c,g),r,o);if(f.total===0)return t.note(o?`No match for ${h} anywhere in this reference.`:`No match for ${h}.`),[];const u=`${f.total.toLocaleString()} site${f.total===1?"":"s"}`;t.note(f.truncated?`${u} — the search stopped at the limit of ${l.toLocaleString()} and there are more. `+(l<un?"Raise “Most sites”, or narrow the pattern.":r.length>1?"That is the most one run reports, so narrow the pattern or tick fewer sequences.":"That is the most one run reports, so narrow the pattern."):`${u}, on ${f.hits.length.toLocaleString()} ${f.hits.length===1?"sequence":"sequences"}.`);const I=`motif-${i}${c?"-both":""}${g>0?`-mm${g}`:""}`+(o?"":_u(r)),d=[Ku(f,i,h,I)],C=qu(t,f,h,I);return C!==null&&d.push(C),d};function Yu(t,e,n){return n?t:e.length<=3?`${t} on ${e.map(A=>A.name).join(", ")}`:`${t} on ${e.length.toLocaleString()} sequences`}function _u(t){const e=t.map(A=>A.name);if(e.length<=3)return`-on-${e.map(A=>A.replace(/[^A-Za-z0-9]/g,"")).join("-")}`;let n=5381;for(const A of e.join(`
+`))n=(n*33^A.charCodeAt(0))>>>0;return`-on${e.length}-${n.toString(36)}`}function Ku(t,e,n,A){return{kind:"intervals",id:A,label:n,payload:{kind:"features",data:vu(t,e)},noun:{one:"site",many:"sites"},display:"lane",look:"point"}}function qu(t,e,n,A){const s=t.framing.binsize,r=Kn(t);if(!(s>0)||r.length===0)return t.note("The sites are a lane; the density is not. A per-bin track needs the bin grid of an open contact map, and this session has none — so there is nothing for a density to be per. Open the map and run it again for that half."),null;const o=na(e,r,s);return{kind:"profile",id:`${A}-density`,label:`${n} density`,values:o.values,extent:[0,o.values.length],binsize:s,unit:"sites"}}function Kn(t){const e=t.inputs.contigLengths;if(e===void 0)return[];const n=[];for(const[A,s]of Object.entries(e))s>0&&n.push({name:A,length:s});return n}let ce=null,An=null;function Hu(){if(ce===null||An===null){ce=new Uint32Array(256);for(let t=0;t<256;t++){const e=Ne[t];ce[t]=e<4?1<<8*e:0}An=new Uint32Array(65536);for(let t=0;t<65536;t++)An[t]=ce[t&255]+ce[t>>>8]}return[ce,An]}const Wu=63;function Ns(t,e){const n=Math.max(1,Math.round(e)),A=t.length===0?0:Math.ceil(t.length/n),s=new Int32Array(A),r=new Int32Array(A),o=new Int32Array(A),i=new Int32Array(A),[a,c]=Hu(),l=4-(t.byteOffset&3)&3,g=new Uint32Array(t.buffer,t.byteOffset+l,Math.max(0,t.length-l>>2));for(let f=0;f<A;f++){const h=f*n,u=Math.min(t.length,h+n),I=Math.min(u,h<=l?l:l+(h-l+3>>2<<2)),d=u-I>>2;let C=0;for(let y=h;y<I;y++)C+=a[t[y]];for(let y=I+4*d;y<u;y++)C+=a[t[y]];let B=C&255,Q=C>>>8&255,E=C>>>16&255,m=C>>>24,p=I-l>>2;const w=p+d;for(;p<w;){const y=Math.min(w,p+Wu);let N=0;for(;p<y;p++){const k=g[p];N+=c[k&65535]+c[k>>>16]}B+=N&255,Q+=N>>>8&255,E+=N>>>16&255,m+=N>>>24}s[f]=B,r[f]=Q,o[f]=E,i[f]=m}return{step:n,steps:A,a:s,c:r,g:o,t:i}}const sa=1<<22;function Pu(t,e=sa){const n=Math.max(1,Math.round(t));return n*Math.max(1,Math.floor(e/n))}async function zu(t,e,n=sa){const A=Math.max(1,Math.round(e)),s=Pu(A,n),r=[];let o=0;for(let l=0;;l+=s){const g=await t(l,l+s);if(g===void 0)return;if(r.push(Ns(g,A)),o+=g.length,g.length<s)break}const i=r.reduce((l,g)=>l+g.steps,0),a={step:A,steps:i,a:new Int32Array(i),c:new Int32Array(i),g:new Int32Array(i),t:new Int32Array(i)};let c=0;for(const l of r)a.a.set(l.a,c),a.c.set(l.c,c),a.g.set(l.g,c),a.t.set(l.t,c),c+=l.steps;return{counts:a,length:o}}function ra(t,e,n){const A=Math.max(0,Math.floor(Math.max(1,Math.round(e))/2)),s=t.steps;if(A===0||s===0)return t;const r=o=>{const i=new Int32Array(s),a=new Float64Array(s+1);for(let g=0;g<s;g++)a[g+1]=a[g]+o[g];const c=a[s],l=g=>{if(!n)return a[Math.max(0,Math.min(s,g))];const f=Math.floor(g/s);return f*c+a[g-f*s]};for(let g=0;g<s;g++){const f=n?g-Math.min(A,Math.floor((s-1)/2)):g-A,h=n?g+Math.min(A,Math.floor((s-1)/2))+1:g+A+1;i[g]=l(h)-l(f)}return i};return{...t,a:r(t.a),c:r(t.c),g:r(t.g),t:r(t.t)}}function Xu(t){const e=new Float32Array(t.steps);for(let n=0;n<t.steps;n++){const A=t.g[n]+t.c[n],s=A+t.a[n]+t.t[n];e[n]=s>0?A/s:Number.NaN}return e}function GA(t){const e=new Float32Array(t.steps);for(let n=0;n<t.steps;n++){const A=t.g[n]+t.c[n];e[n]=A>0?(t.g[n]-t.c[n])/A:Number.NaN}return e}function Vu(t){const e=new Float32Array(t.steps);for(let n=0;n<t.steps;n++){const A=t.a[n]+t.t[n];e[n]=A>0?(t.a[n]-t.t[n])/A:Number.NaN}return e}function oa(t){const e=new Float32Array(t.length);let n=0;for(let A=0;A<t.length;A++){const s=t[A];Number.isFinite(s)&&(n+=s),e[A]=n}return e}const Zu=1e4;function ju(t){return["gc","gcSkew","atSkew","cumulative"].filter(e=>t[e]!==!1)}function tI(t){return qi(t.framing)}const Gr={gc:{name:"GC content",unit:""},gcSkew:{name:"GC skew",unit:""},atSkew:{name:"AT skew",unit:""},cumulative:{name:"Cumulative GC skew",unit:""}},eI=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to read."),[];if(e===null)return t.note("No reference was chosen. Load a FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.read===void 0&&n.refusal!==void 0)return t.note(n.refusal),[];const A=ju(t.params);if(A.length===0)return t.note("No track was ticked, so there is nothing to make."),[];const s=T(t.params,"resolution",0),r=s>0?Math.round(s):t.framing.binsize>0&&!tI(t)?t.framing.binsize:Zu,o=Kn(t);if(o.length===0)return t.note("There are no sequences to lay the bins out on. Open a map, or load the FASTA itself."),[];const i=Math.max(0,Math.round(T(t.params,"window",0))),a=Math.max(1,Math.round(i/r)),c=a%2===1?a:a+1,l=new Set(t.framing.circular??[]),g=o.reduce((E,m)=>E+Math.max(1,Math.ceil(m.length/r)),0),f={gc:new Float32Array(g).fill(Number.NaN),gcSkew:new Float32Array(g).fill(Number.NaN),atSkew:new Float32Array(g).fill(Number.NaN),cumulative:new Float32Array(g).fill(Number.NaN)},{read:h}=n,u=[],I=[];let d=0;for(let E=0;E<o.length;E++){const m=o[E],p=Math.max(1,Math.ceil(m.length/r));t.progress(E,o.length,m.name);let w;if(h!==void 0)w=await zu((M,F)=>(t.throwIfCancelled(),h(m.name,M,F)),r);else{const M=n.bases(m.name);w=M===void 0?void 0:{counts:Ns(M,r),length:M.length}}if(w===void 0){u.push(m.name),d+=p;continue}w.length!==m.length&&I.push(m.name);const{counts:y}=w,N=c>1?ra(y,c,l.has(m.name)):y,k={gc:Xu(N),gcSkew:GA(N),atSkew:Vu(N),cumulative:oa(GA(y))},b=Math.min(p,y.steps);for(const M of A)f[M].set(k[M].subarray(0,b),d);d+=p}if(t.progress(o.length,o.length,"done"),u.length===o.length)return t.note("The reference has none of the map’s sequences under any name this viewer knows, so nothing could be measured."),[];u.length>0&&t.note(`${u.length.toLocaleString()} of the map’s sequences are not in this reference and are gaps on every track: ${u.slice(0,6).join(", ")}${u.length>6?", …":""}.`),I.length>0&&t.note(`${I.slice(0,6).join(", ")}${I.length>6?", …":""} ${I.length===1?"is":"are"} not the length the map says — the reference may be another assembly version. Bins were read from its start.`),c>1&&t.note(`Each bin was read over ${c} bins (${(c*r).toLocaleString()} bp) centred on it; the cumulative skew sums each bin’s own.`);const C=t.inputs.labels?.[e]??"reference",B=c>1?` · ${(c*r).toLocaleString()} bp window`:"";return A.map(E=>({kind:"profile",id:`composition-${E.toLowerCase()}`,label:`${Gr[E].name} · ${C}${E==="cumulative"?"":B}`,values:f[E],extent:[0,g],binsize:r,unit:Gr[E].unit}))},_e=19,ia=50,nI=2e6,AI=5e3,sI=500,rI=10;function xr(t){const e=[0];for(const n of t)e.push(e[e.length-1]+n.length);return{names:t.map(n=>n.name),lengths:t.map(n=>n.length),offsets:e}}function oI(t,e=nI){return Math.max(1,Math.ceil(2*t/e-1))}const iI=(()=>{const t=new Int8Array(256).fill(-1);for(const[e,n]of[["A",0],["C",1],["G",2],["T",3]])t[e.charCodeAt(0)]=n,t[e.toLowerCase().charCodeAt(0)]=n;return t})();function aI(t){const e=t>>>0,n=Math.floor(t/4294967296)>>>0;let A=Math.imul(e^Math.imul(n,2654435761),2246822507);return 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m=iI[l[E]];if(m<0){u=0,d=0,B=0;continue}if(f=f%r*4+m,h=Math.floor(h/4)+(3-m)*r,u++,u<A)continue;const p=E-A+1;if(B++,f===h)continue;const w=f<h?1:-1,y=aI(f<h?f:h);for(;d>0&&o[(I+d-1)%Q]>=y;)d--;for(o[(I+d)%Q]=y,i[(I+d)%Q]=p,a[(I+d)%Q]=w,d++;d>0&&i[I]<=p-n;)I=(I+1)%Q,d--;if(B<n)continue;const N=i[I];N!==C&&(s.push(o[I],g+N,a[I]),C=N)}}return s.finish()}function Fn(t,e=t.length,n){let A=new Uint32Array(e);if(n===void 0)for(let o=0;o<e;o++)A[o]=o;else A.set(n.subarray(0,e));let s=new Uint32Array(e);const r=new Uint32Array(65537);for(const o of[0,16]){r.fill(0);for(let i=0;i<e;i++)r[(t[A[i]]>>>o&65535)+1]++;for(let i=0;i<65536;i++)r[i+1]+=r[i];for(let i=0;i<e;i++)s[r[t[A[i]]>>>o&65535]++]=A[i];[A,s]=[s,A]}return A}function lI(t,e,n=ia){const A=Fn(t.hash,t.count),s=Fn(e.hash,e.count);let r=new Uint32Array(1024),o=new Uint32Array(1024),i=new Int8Array(1024),a=0,c=0,l=0,g=0;for(;l<t.count&&g<e.count;){const f=t.hash[A[l]],h=e.hash[s[g]];if(f<h){l++;continue}if(h<f){g++;continue}let u=l;for(;u<t.count&&t.hash[A[u]]===f;)u++;let I=g;for(;I<e.count&&e.hash[s[I]]===h;)I++;if(u-l>n||I-g>n)c++;else for(let d=l;d<u;d++)for(let C=g;C<I;C++){if(a===r.length){const B=r.length*2,Q=new Uint32Array(B);Q.set(r),r=Q;const E=new Uint32Array(B);E.set(o),o=E;const m=new Int8Array(B);m.set(i),i=m}r[a]=t.position[A[d]],o[a]=e.position[s[C]],i[a]=t.strand[A[d]]===e.strand[s[C]]?1:-1,a++}l=u,g=I}return{x:r.slice(0,a),y:o.slice(0,a),strand:i.slice(0,a),count:a,dropped:c}}function gI(t,e=AI,n=sI,A=rI,s){const r=[];s?.fill(-1);let o=0;for(let a=0;a<t.count;a++)t.y[a]>o&&(o=t.y[a]);for(const a of[1,-1]){let c=0;for(let Q=0;Q<t.count;Q++)t.strand[Q]===a&&c++;const l=new Uint32Array(c),g=new Uint32Array(c),f=new Uint32Array(c),h=Math.ceil(o/n)+1;for(let Q=0,E=0;Q<t.count;Q++)t.strand[Q]===a&&(l[E]=Q,g[E]=t.x[Q],f[E]=a===1?Math.round((t.x[Q]-t.y[Q])/n)+h:Math.round((t.x[Q]+t.y[Q])/n),E++);const u=Fn(f,c,Fn(g,c)),I=new Uint32Array(c),d=new Uint32Array(c);for(let Q=0;Q<c;Q++)I[Q]=l[u[Q]],d[Q]=f[u[Q]];let C=0;const B=Q=>{const E=Q-C;if(E>=A){let m=Number.POSITIVE_INFINITY,p=Number.NEGATIVE_INFINITY,w=Number.POSITIVE_INFINITY,y=Number.NEGATIVE_INFINITY;for(let N=C;N<Q;N++){const k=I[N];m=Math.min(m,t.x[k]),p=Math.max(p,t.x[k]+_e),w=Math.min(w,t.y[k]),y=Math.max(y,t.y[k]+_e)}if(s!==void 0)for(let N=C;N<Q;N++)s[I[N]]=r.length;r.push({x0:m,x1:p,y0:w,y1:y,strand:a,anchors:E})}C=Q};for(let Q=1;Q<=I.length;Q++){if(Q===I.length){B(Q);break}const E=I[Q-1],m=I[Q];(d[Q-1]!==d[Q]||t.x[m]-t.x[E]>e)&&B(Q)}}const i=r.map((a,c)=>c).sort((a,c)=>r[a].x0-r[c].x0||r[a].y0-r[c].y0);if(s!==void 0){const a=new Int32Array(r.length);i.forEach((c,l)=>a[c]=l);for(let c=0;c<t.count;c++)s[c]>=0&&(s[c]=a[s[c]])}return i.map(a=>r[a])}const fI=100,hI=4e5;function uI(t,e,n){const A=e.offsets[e.offsets.length-1],s=n.offsets[n.offsets.length-1],r=Math.max(fI,Math.ceil(Math.max(A,s)/hI)),o=new Uint8Array(Math.ceil(A/r)+1),i=new Uint8Array(Math.ceil(s/r)+1),a=(h,u)=>{const I=Math.floor(h/r);return[I,Math.max(I+1,Math.ceil(u/r))]},c=(h,u,I)=>{const[d,C]=a(u,I);let B=0;for(let Q=d;Q<C;Q++)B+=h[Q];return B/(C-d)},l=(h,u,I)=>{const[d,C]=a(u,I);h.fill(1,d,C)},g=new Uint8Array(t.length),f=t.map((h,u)=>u).sort((h,u)=>t[u].anchors-t[h].anchors||h-u);for(const h of f){const u=t[h];c(o,u.x0,u.x1)>.5||c(i,u.y0,u.y1)>.5||(g[h]=1,l(o,u.x0,u.x1),l(i,u.y0,u.y1))}return g}function II(t,e,n,A,s){const r=e.offsets[e.offsets.length-1],o=n.offsets[n.offsets.length-1],i=Math.max(1,Math.ceil(Math.max(r,o)/Math.max(1,A))),a=Math.max(1,Math.ceil(r/i)),c=Math.max(1,Math.ceil(o/i)),l=new Float32Array(a*c);for(let g=0;g<t.count;g++){if(s!==void 0&&s[g]!==1)continue;const f=Math.min(a-1,Math.floor(t.x[g]/i)),h=Math.min(c-1,Math.floor(t.y[g]/i));l[h*a+f]+=t.strand[g]}return{values:l,ncols:a,nrows:c,cellSize:i}}function Ur(t,e){let n=0,A=t.names.length-1;for(;n<A;){const s=n+A+1>>1;t.offsets[s]<=e?n=s:A=s-1}return{sequence:n,at:e-t.offsets[n]}}const Tr=400;function dI(t,e,n,A,s){const r=t.length,o={x:{label:A,names:[...e.names],lengths:[...e.lengths]},y:{label:s,names:[...n.names],lengths:[...n.lengths]},x0:new Float64Array(r),x1:new Float64Array(r),y0:new Float64Array(r),y1:new Float64Array(r),strand:new Int8Array(r),anchors:new Int32Array(r)};return t.forEach((i,a)=>{o.x0[a]=i.x0,o.x1[a]=i.x1,o.y0[a]=i.y0,o.y1[a]=i.y1,o.strand[a]=i.strand,o.anchors[a]=i.anchors}),o}function $r(t,e){return t.names.map((n,A)=>({label:n,from:t.offsets[A]/e,to:t.offsets[A+1]/e}))}const CI=async t=>{const e=at(t.params,"x"),n=at(t.params,"y");if(t.residues===void 0)return t.note("This session cannot read residues, so there is nothing to set against anything."),[];if(e===null||n===null)return t.note("Choose the two sequence sets: one along x, one along y."),[];const A=t.residues(e),s=t.residues(n);if(A===void 0||s===void 0)return t.note("A sequence set chosen is no longer loaded. Drop the FASTA again, or pick another."),[];for(const S of[A,s])if(S.refusal!==void 0)return t.note(S.refusal),[];const r=xr(A.contigs),o=xr(s.contigs),i=r.offsets[r.offsets.length-1],a=oI(i);t.progress(0,4,"minimizers along x");const c=vr(r,S=>A.bases(S),a);t.throwIfCancelled(),t.progress(1,4,"minimizers along y");const l=vr(o,S=>s.bases(S),a);t.throwIfCancelled(),t.progress(2,4,"anchors");const g=lI(c,l);t.throwIfCancelled(),t.progress(3,4,"streaks");const f=new Int32Array(g.count),h=gI(g,void 0,void 0,void 0,f),u=e===n,I=!u&&st(t.params,"streaks","one to one")==="one to one",d=I?uI(h,r,o):new Uint8Array(h.length).fill(1),C=h.filter((S,v)=>d[v]===1),B=new Uint8Array(g.count);for(let S=0;S<g.count;S++)f[S]>=0&&d[f[S]]===1&&(B[S]=1);const Q=Math.round(T(t.params,"cells",Tr)),E=II(g,r,o,Q>0?Q:Tr,B);t.progress(4,4);const m=c.count>0?Math.round(i/c.count):0,p=h.length-C.length;t.note(`Exact ${_e}-mers, one in about ${m.toLocaleString("en-US")} bases; hashes above ${ia} copies on either side dropped (${g.dropped.toLocaleString("en-US")} of them). ${g.count.toLocaleString("en-US")} anchors, ${h.length.toLocaleString("en-US")} streaks`+(I?`, ${C.length.toLocaleString("en-US")} of them one to one — ${p.toLocaleString("en-US")} a stronger streak had taken the stretch of`:"")+(u?", every one drawn, the set against itself":"")+`. Not an alignment, and it writes none: a streak is ten or more shared ${_e}-mers along one diagonal.`);const w=[];for(const S of E.values)Math.abs(S)>=3&&w.push(Math.abs(S));w.sort((S,v)=>S-v);const y=w.length===0?3:Math.max(3,w[Math.floor(.5*(w.length-1))]),N={kind:"matrix",id:"dotplot-density",label:I?"Streaks one to one, the same way round (red) and the other (blue)":"Streaks, the same way round (red) and the other (blue)",nrows:E.nrows,ncols:E.ncols,values:E.values,xLabel:"along x",yLabel:"along y",xTicks:[],yTicks:[],colormap:"RdBu_r",centre:0,range:[-y,y],xSegments:$r(r,E.cellSize),ySegments:$r(o,E.cellSize),stats:[{label:"anchors",value:g.count},{label:I?"streaks one to one":"streaks",value:C.length},{label:"bases a cell",value:E.cellSize}],large:!0,streaks:dI(C,r,o,t.inputs.labels?.[e]??"along x",t.inputs.labels?.[n]??"along y")},k=C.map(S=>{const v=Ur(r,S.x0),G=Ur(o,S.y0);return{xSequence:r.names[v.sequence],xStart:v.at,xEnd:v.at+(S.x1-S.x0),ySequence:o.names[G.sequence],yStart:G.at,yEnd:G.at+(S.y1-S.y0),strand:S.strand===1?"+":"-",anchors:S.anchors}}),b={kind:"table",id:"dotplot-streaks",label:"Streaks",columns:[{key:"xSequence",label:"x sequence",kind:"text"},{key:"xStart",label:"x start",kind:"number",coordinate:"start"},{key:"xEnd",label:"x end",kind:"number",coordinate:"end"},{key:"ySequence",label:"y sequence",kind:"text"},{key:"yStart",label:"y start",kind:"number",coordinate:"start"},{key:"yEnd",label:"y end",kind:"number",coordinate:"end"},{key:"strand",label:"strand",kind:"text",hint:"+ the same way round, − the other"},{key:"anchors",label:"anchors",kind:"number"}],rows:k},M=new $n;for(const S of k)M.add(S.xSequence,S.xStart,S.xEnd,S.ySequence,S.yStart,S.yEnd,{score:S.anchors,name:S.strand==="+"?"same way round":"the other way round",detail:`${S.anchors} anchors`});const F={kind:"intervals",id:"dotplot-pairs",label:"Streaks, as pairs",payload:{kind:"pairs",data:M.finish()},noun:{one:"streak",many:"streaks"},display:"overlay"};return[N,b,F]};function xA(t,e,n,A){const s=Math.abs(t-e);return A&&n>0?Math.min(s,n-s%n):s}function QI(t,e,n){if(t.length===0)return Number.NaN;if(!n||!(e>0)){let i=0;for(const a of t)i+=a;return i/t.length}let A=0,s=0;for(const i of t){const a=2*Math.PI*i/e;A+=Math.sin(a),s+=Math.cos(a)}const o=(Math.atan2(A,s)/(2*Math.PI)*e%e+e)%e;return o>=e?0:o}function Jr(t,e,n,A){if(t.length===0)return null;let s=-1,r=0;for(let i=0;i<t.length;i++){let a=0;for(const c of t)xA(t[i],c,e,n)<=A&&a++;a>r&&(r=a,s=i)}const o=t.filter(i=>xA(t[s],i,e,n)<=A);return{centre:QI(o,e,n),count:o.length}}function BI(t,e,n){let A=-1,s=-1;for(let o=0;o<t.length;o++){const i=t[o];Number.isFinite(i)&&((A<0||i<t[A])&&(A=o),(s<0||i>t[s])&&(s=o))}const r=o=>o<0?Number.NaN:Math.min(n-1,Math.floor(o*e+e/2));return{low:r(A),high:r(s)}}const EI=10;function mI(t){const{length:e,circular:n,low:A,high:s}=t,r=e/8,o=Jr(t.matS,e,n,r),i=Jr(t.parS,e,n,r),a=t.minMatS??EI,c=(h,u)=>xA(h,u,e,n);let l=s,g="skew";if(o!==null&&t.matS.length>=a)l=c(A,o.centre)<c(s,o.centre)?A:s,g="matS";else if(i!==null)l=c(A,i.centre)>c(s,i.centre)?A:s,g="parS";else if(t.coverageAt!==void 0){const h=t.coverageAt(A),u=t.coverageAt(s);Number.isFinite(h)&&Number.isFinite(u)&&h!==u&&(l=h<u?A:s,g="coverage")}return{ori:l===s?A:s,ter:l,rule:g,agreesWithSkew:l===s,matS:o,parS:i}}function wI(t,e,n,A,s){const r=Math.max(s?3:1,Math.round(A)),o=s?r:r+3,i=n>0?r/n:0,a=Q=>{let E=Q*i;s||(E=Math.max(0,Math.min(r-1e-9,E)));const m=Math.floor(E),p=E-m,w=[(1-p)**3/6,(3*p**3-6*p**2+4)/6,(-3*p**3+3*p**2+3*p+1)/6,p**3/6];return{first:s?m-1:m,w}},c=Q=>s?(Q%o+o)%o:Q,l=new Float64Array(o*o),g=new Float64Array(o);let f=0;for(let Q=0;Q<t.length;Q++){const E=e[Q];if(!Number.isFinite(E))continue;f++;const{first:m,w:p}=a(t[Q]);for(let w=0;w<4;w++){const y=c(m+w);g[y]+=p[w]*E;for(let N=0;N<4;N++)l[y*o+c(m+N)]+=p[w]*p[N]}}let h=0,u=0;for(let Q=0;Q<e.length;Q++)Number.isFinite(e[Q])&&(h+=e[Q],u++);h=u>0?h/u:0;const I=1e-6*Math.max(1,f/o);for(let Q=0;Q<o;Q++)l[Q*o+Q]+=I,g[Q]+=I*h;const d=pI(l,g,o),C=Q=>{if(d===null)return Number.NaN;const{first:E,w:m}=a(Q);let p=0;for(let w=0;w<4;w++)p+=m[w]*d[c(E+w)];return p},B=new Float64Array(t.length);for(let Q=0;Q<t.length;Q++)B[Q]=C(t[Q]);return{fitted:B,at:C}}function pI(t,e,n){const A=Float64Array.from(t),s=Float64Array.from(e);for(let o=0;o<n;o++){let i=o;for(let a=o+1;a<n;a++)Math.abs(A[a*n+o])>Math.abs(A[i*n+o])&&(i=a);if(Math.abs(A[i*n+o])<1e-300)return null;if(i!==o){for(let c=0;c<n;c++){const l=A[o*n+c];A[o*n+c]=A[i*n+c],A[i*n+c]=l}const a=s[o];s[o]=s[i],s[i]=a}for(let a=o+1;a<n;a++){const c=A[a*n+o]/A[o*n+o];if(c!==0){for(let l=o;l<n;l++)A[a*n+l]-=c*A[o*n+l];s[a]-=c*s[o]}}}const r=new Float64Array(n);for(let o=n-1;o>=0;o--){let i=s[o];for(let a=o+1;a<n;a++)i-=A[o*n+a]*r[a];r[o]=i/A[o*n+o]}return r}function yI(t){let e=Number.NEGATIVE_INFINITY,n=Number.POSITIVE_INFINITY;for(const s of t)Number.isFinite(s)&&(s>e&&(e=s),s<n&&(n=s));return{ratio:n>0&&Number.isFinite(e)?e/n:Number.NaN,highest:e,lowest:n}}const NI="TGTTNCACGTGNAACA",kI="GTGACRNYGTCAC";function bI(t,e){const n=t[e];return n==null?e==="parS"?NI:kI:typeof n=="string"?n.replace(/\s+/g,"").toUpperCase():""}const MI=5e3,cA={matS:"nearest the matS cluster",parS:"farthest from the parS cluster",coverage:"lower coverage",skew:"skew maximum"};function Or(t,e,n){const A={mids:[],starts:[],ends:[],strands:[],mismatches:[]};if(e===null)return A;for(const s of ys(t,e,{bothStrands:!0,mismatches:n}).hits)A.mids.push((s.start+s.end)/2),A.starts.push(s.start),A.ends.push(s.end),A.strands.push(s.strand),A.mismatches.push(s.mismatches);return A}const DI=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to read."),[];if(e===null)return t.note("No reference was chosen. Load the genome’s FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.refusal!==void 0)return t.note(n.refusal),[];const A={parS:{motif:null,pattern:"",mismatches:0},matS:{motif:null,pattern:"",mismatches:0}};for(const N of["parS","matS"]){const k=bI(t.params,N);if(k==="")continue;const b=Ye(k);if(Oe(b)){t.note(`${N}: ${b.reason} Its step was skipped.`);continue}const M=Math.round(T(t.params,`${N}Mismatches`,N==="parS"?1:0));A[N]={motif:b,pattern:k,mismatches:Math.max(0,Math.min(b.length-1,M))}}const s=Math.max(100,Math.round(T(t.params,"window",5e3))),r=Math.max(10,Math.min(s,Math.round(T(t.params,"step",1e3)))),o=Math.max(4,Math.min(40,Math.round(T(t.params,"knots",10)))),i=at(t.params,"coverage"),a=new Set(t.framing.circular??[]),c=Kn(t),l=c.length>0?c.map(N=>N.name):n.contigs.map(N=>N.name),g=Yn(t.params,"sequences"),f=g===null?l:l.filter(N=>g.includes(N));if(f.length===0)return t.note("No sequence is ticked, so there is nothing to read."),[];const h=new et,u=new et,I=new et;let d=0,C=0;const B=[],Q=new Map,E=[];for(let N=0;N<f.length;N++){const k=f[N];t.progress(N,f.length,k);const b=n.bases(k);if(b===void 0){E.push(k);continue}const M=b.length;if(M<4*s){E.push(k);continue}const F=a.has(k),S=Ns(b,r),v=GA(ra(S,Math.max(1,Math.round(s/r)),F)),G=BI(oa(v),r,M);if(!Number.isFinite(G.low)||!Number.isFinite(G.high)){E.push(k);continue}const O=Or(b,A.parS.motif,A.parS.mismatches),$=Or(b,A.matS.motif,A.matS.mismatches);let K,V=Number.NaN;if(i!==null){const L=(await t.sample(i,[{contig:k,start:0,end:M}],MI)).regions[0];if(L!==void 0&&L.values.length>3){const J=new Float64Array(L.values.length),Mt=new Float64Array(L.values.length);for(let P=0;P<L.values.length;P++)J[P]=(L.starts[P]+L.ends[P])/2,Mt[P]=L.values[P];const vt=wI(J,Mt,M,o,F);K=vt.at,Q.set(k,vt.at),V=yI(vt.fitted).ratio}}const H=mI({length:M,circular:F,low:G.low,high:G.high,parS:O.mids,matS:$.mids,...K===void 0?{}:{coverageAt:K}}),ht=Math.floor(s/2),xt=`${cA[H.rule]}${H.agreesWithSkew?"":" · disagrees with the skew"}`;for(const[q,L]of[["ori",H.ori],["ter",H.ter]])h.add(k,Math.max(0,L-ht),Math.min(M,L+ht),{name:q,detail:q==="ter"?`terminus · ${xt}`:"origin"});for(let q=0;q<O.starts.length;q++)u.add(k,O.starts[q],O.ends[q],{strand:O.strands[q],name:"parS",score:O.mismatches[q],detail:`${O.mismatches[q]} ${O.mismatches[q]===1?"mismatch":"mismatches"}`});for(let q=0;q<$.starts.length;q++)I.add(k,$.starts[q],$.ends[q],{strand:$.strands[q],name:"matS",score:$.mismatches[q],detail:`${$.mismatches[q]} ${$.mismatches[q]===1?"mismatch":"mismatches"}`});d+=O.starts.length,C+=$.starts.length,H.agreesWithSkew||t.note(`${k}: the terminus was placed ${cA[H.rule]}, at the cumulative skew’s minimum — which is where the skew alone would put the origin. Check the assembly, or the motifs.`),B.push({sequence:k,length:M,topology:F?"circular":"linear",ori:H.ori+1,ter:H.ter+1,rule:cA[H.rule],parS:O.starts.length,parSCluster:H.parS?.count??0,matS:$.starts.length,ratio:V})}if(t.progress(f.length,f.length,"done"),E.length>0&&t.note(`${E.length.toLocaleString()} ${E.length===1?"sequence was":"sequences were"} not placed — not in the reference, or shorter than four skew windows: ${E.slice(0,6).join(", ")}${E.length>6?", …":""}.`),B.length===0)return[];i===null&&t.note("No coverage track was chosen, so there is no ori/ter ratio and no coverage step.");const m=B.filter(N=>N.topology==="linear").length;m>0&&t.note(`${m.toLocaleString()} ${m===1?"sequence was":"sequences were"} read as linear. A bacterial chromosome is usually circular — tick it in the Chromosomes table and run this again, or the origin at its first base is split between its two ends.`);const w=[{kind:"intervals",id:"oriter-loci",label:`Origin and terminus · ${t.inputs.labels?.[e]??"reference"}`,payload:{kind:"features",data:h.finish()},noun:{one:"locus",many:"loci"},display:"lane",look:"point"}];d>0&&w.push({kind:"intervals",id:"oriter-pars",label:`parS sites · ${A.parS.pattern}`,payload:{kind:"features",data:u.finish()},noun:{one:"site",many:"sites"},display:"lane",look:"point"}),C>0&&w.push({kind:"intervals",id:"oriter-mats",label:`matS sites · ${A.matS.pattern}`,payload:{kind:"features",data:I.finish()},noun:{one:"site",many:"sites"},display:"lane",look:"point"});const y=t.framing.binsize;if(Q.size>0&&y>0&&c.length>0){const N=c.reduce((F,S)=>F+Math.max(1,Math.ceil(S.length/y)),0),k=new Float32Array(N).fill(Number.NaN);let b=0;for(const F of c){const S=Math.max(1,Math.ceil(F.length/y)),v=Q.get(F.name);if(v!==void 0)for(let G=0;G<S;G++)k[b+G]=v(Math.min(F.length-1,(G+.5)*y));b+=S}const M=t.inputs.labels?.[i??""]??"coverage";w.push({kind:"profile",id:"oriter-coverage-fit",label:`${M} · spline fit`,values:k,extent:[0,N],binsize:y,unit:""})}return w.push({kind:"table",id:"oriter-table",label:"Origin and terminus per sequence",columns:[{key:"sequence",label:"sequence",kind:"text"},{key:"length",label:"length",kind:"number"},{key:"topology",label:"read as",kind:"text"},{key:"ori",label:"ori",kind:"number",hint:"Centre of the origin locus, 1-based."},{key:"ter",label:"ter",kind:"number",hint:"Centre of the terminus locus, 1-based."},{key:"rule",label:"terminus placed by",kind:"text"},{key:"parS",label:"parS",kind:"number",hint:"Sites found on this sequence."},{key:"parSCluster",label:"in cluster",kind:"number",hint:"parS sites within an eighth of the sequence of the densest one."},{key:"matS",label:"matS",kind:"number",hint:"Sites found on this sequence."},{key:"ratio",label:"ori/ter",kind:"number",digits:2,hint:"Highest over lowest smoothed coverage: copies of the origin per copy of the terminus."}],rows:B}),w};function vA(t,e,n){const A=t.contigs.indexOf(e);if(A<0)return[];const s=[];for(let r=t.contigAt[A];r<t.contigAt[A+1];r++){const o=t.start[r],i=t.end[r];if(i<=o)continue;const a=s[s.length-1];a!==void 0&&o<=a[1]?a[1]=Math.max(a[1],i):s.push([o,i])}return s}function Yr(t){let e=0;for(const[n,A]of t)e+=A-n;return e}function FI(t,e){let n=0,A=0,s=0;for(;A<t.length&&s<e.length;){const r=Math.max(t[A][0],e[s][0]),o=Math.min(t[A][1],e[s][1]);o>r&&(n+=o-r),t[A][1]<e[s][1]?A++:s++}return n}function _r(t,e,n,A){const s=t.contigs.indexOf(e);if(s<0||n.length===0)return 0;let r=0,o=0;for(let i=t.contigAt[s];i<t.contigAt[s+1];i++){const a=t.start[i],c=t.end[i],l=c-a;if(l<=0)continue;for(;o<n.length&&n[o][1]<=a;)o++;let g=0;for(let f=o;f<n.length&&n[f][0]<c;f++)g+=Math.max(0,Math.min(c,n[f][1])-Math.max(a,n[f][0]));g/l>=A&&g>0&&r++}return r}function aa(t,e,n){const A=new Set([...t.contigs,...e.contigs]);let s=0,r=0,o=0,i=0,a=0;for(const l of A){const g=vA(t,l,n.minFraction),f=vA(e,l,n.minFraction);s+=Yr(g),r+=Yr(f),o+=FI(g,f),i+=_r(t,l,f,n.minFraction),a+=_r(e,l,g,n.minFraction)}const c=s+r-o;return{basesA:s,basesB:r,intersection:o,union:c,jaccard:c>0?o/c:Number.NaN,featuresAHit:i,featuresBHit:a,featuresA:t.length,featuresB:e.length}}function SI(t,e,n,A,s){let r=0,o=0,i=0,a=0,c=0,l=Number.NaN,g=Number.NaN;const f=()=>{if(!Number.isNaN(l)){for(o+=g-l;c<A.length&&A[c][1]<=l;)c++;for(let h=c;h<A.length&&A[h][0]<g;h++)r+=Math.min(g,A[h][1])-Math.max(l,A[h][0])}};for(let h=0;h<n.length;h++){const u=n[h],I=t[u],d=I+e[u];for(;a<A.length&&A[a][1]<=I;)a++;let C=0;for(let Q=a;Q<A.length&&A[Q][0]<d;Q++)C+=Math.max(0,Math.min(d,A[Q][1])-Math.max(I,A[Q][0]));const B=d-I;B>0&&C>0&&C/B>=s&&i++,Number.isNaN(l)?(l=I,g=d):I<=g?g=Math.max(g,d):(f(),l=I,g=d)}return f(),{intersection:r,covered:o,hits:i}}function lA(t,e){const n=e.length;let A=0;for(let c=0;c<n;c++)A+=e[c];const s=n>0?A/n:Number.NaN;let r=0;for(let c=0;c<n;c++)r+=(e[c]-s)**2;const o=n>1?Math.sqrt(r/(n-1)):Number.NaN;let i=0,a=0;for(let c=0;c<n;c++)e[c]>=t&&i++,e[c]<=t&&a++;return{observed:t,mean:s,sd:o,z:o>0?(t-s)/o:Number.NaN,fold:s>0?t/s:Number.NaN,pEnriched:(i+1)/(n+1),pDepleted:(a+1)/(n+1)}}function RI(t,e,n){const A=aa(t,e,{minFraction:n.minFraction}),s=[],r=[],o=[];for(const I of t.contigs){const d=t.contigs.indexOf(I),C=[];let B=0;for(let m=t.contigAt[d];m<t.contigAt[d+1];m++){const p=t.end[m]-t.start[m];p<=0||(C.push(p),B=Math.max(B,t.end[m]))}if(C.length===0)continue;let E=n.lengthOf(I);if(E===void 0||E<=0){const m=e.contigs.indexOf(I);let p=B;if(m>=0)for(let w=e.contigAt[m];w<e.contigAt[m+1];w++)p=Math.max(p,e.end[w]);E=p,r.push(I)}if(!Number.isFinite(E)||E<=0){o.push(I);continue}s.push({contig:I,length:E,lengths:C,runs:vA(e,I)})}if(s.length===0)return null;const i=Math.max(1,Math.trunc(n.iterations)),a=ji(n.seed),c=new Float64Array(i),l=new Float64Array(i),g=new Float64Array(i);let f=0;for(const I of s)f=Math.max(f,I.lengths.length);const h=new Float64Array(f),u=new Int32Array(f);for(let I=0;I<i;I++){if(n.cancelled?.()===!0)return null;let d=0,C=0,B=0;for(const E of s){const m=E.lengths.length;for(let y=0;y<m;y++){const N=Math.max(0,E.length-E.lengths[y]);h[y]=Math.floor(a()*(N+1)),u[y]=y}const p=u.subarray(0,m);p.sort((y,N)=>h[y]-h[N]);const w=SI(h,E.lengths,p,E.runs,n.minFraction);d+=w.intersection,C+=w.covered,B+=w.hits}l[I]=d,g[I]=B;const Q=C+A.basesB-d;c[I]=Q>0?d/Q:Number.NaN,n.onProgress?.(I+1,i)}return{iterations:i,jaccard:lA(A.jaccard,c),intersection:lA(A.intersection,l),featuresHit:lA(A.featuresAHit,g),assumedLengths:r,droppedContigs:o}}const LI=async t=>{const e=ne(t.inputs.features,t.params,"a"),n=ne(t.inputs.features,t.params,"b"),A=e.value,s=n.value;if(A===void 0||s===void 0){const u=[e,n].filter(d=>d.value===void 0),I=u.filter(d=>d.chosen).length;return t.note(I===u.length?`The interval ${u.length===2?"sets":"set"} chosen ${u.length===2?"are":"is"} no longer loaded. Re-open the file, or pick another.`:`Two interval sets are needed and ${u.length===2&&I===0?"neither has":"one has not"} been chosen. Load two BED files, or a BED and a GTF, and pick one in each box.`),[]}t.progress(0,1,"comparing");const r=aa(A,s,{minFraction:Math.max(0,Math.min(1,T(t.params,"minFraction",1e-6)))});t.progress(1,1,"done"),Number.isFinite(r.jaccard)||t.note("Neither set covers any bases, so there is nothing to compare.");const i=[{kind:"table",id:"overlap",label:"Overlap",columns:[{key:"measure",label:"Measure",kind:"text"},{key:"value",label:"Value",kind:"number",digits:4},{key:"note",label:"Note",kind:"text"}],rows:[{measure:"Jaccard (bases)",value:r.jaccard,note:"Symmetric; 1 is identical."},{measure:"Shared bases",value:r.intersection,note:""},{measure:"Bases in either",value:r.union,note:""},{measure:"Bases in the first",value:r.basesA,note:"After merging its own overlaps."},{measure:"Bases in the second",value:r.basesB,note:"After merging its own overlaps."},{measure:"First set hit",value:r.featuresA===0?Number.NaN:r.featuresAHit/r.featuresA,note:`${r.featuresAHit.toLocaleString()} of ${r.featuresA.toLocaleString()} features.`},{measure:"Second set hit",value:r.featuresB===0?Number.NaN:r.featuresBHit/r.featuresB,note:`${r.featuresBHit.toLocaleString()} of ${r.featuresB.toLocaleString()} features.`}]}];if(!Lt(t.params,"shuffle",!1))return i;const a=st(t.params,"shuffleWhich","a")!=="b",c=Math.max(20,Math.trunc(T(t.params,"iterations",1e3)));t.progress(0,c,"shuffling");const l=RI(a?A:s,a?s:A,{minFraction:Math.max(0,Math.min(1,T(t.params,"minFraction",1e-6))),iterations:c,seed:T(t.params,"seed",1),lengthOf:u=>t.lengthOf(u),cancelled:()=>t.cancelled(),onProgress:(u,I)=>t.progress(u,I,"shuffling")});if(t.throwIfCancelled(),l===null)return t.note("The set chosen to move occupies no sequence this session knows a length for, so there was nothing to shuffle it within. Load the assembly — a chrom.sizes, or the map itself."),i;l.assumedLengths.length>0&&t.note(`${l.assumedLengths.length.toLocaleString()} sequence${l.assumedLengths.length===1?" has":"s have"} no known length, so the null was drawn over the furthest position either set reaches there — which is shorter than the sequence and overstates the enrichment. ${l.assumedLengths.slice(0,6).join(", ")}${l.assumedLengths.length>6?", …":""}.`),l.droppedContigs.length>0&&t.note(`${l.droppedContigs.length.toLocaleString()} sequence${l.droppedContigs.length===1?"":"s"} could not be shuffled at all and ${l.droppedContigs.length===1?"is":"are"} left out of the null: ${l.droppedContigs.slice(0,6).join(", ")}${l.droppedContigs.length>6?", …":""}.`);const g=a?"first":"second",f=(u,I,d)=>({measure:u,observed:I.observed,expected:I.mean,fold:I.fold,z:I.z,p:I.observed>=I.mean?I.pEnriched:I.pDepleted,tail:I.observed>=I.mean?"enriched":"depleted",digits:d}),h=[f("Jaccard (bases)",l.jaccard,4),f("Shared bases",l.intersection,0),f(`Features of the ${g} set hit`,l.featuresHit,0)].map(({digits:u,...I})=>I);return i.push({kind:"table",id:"overlap-null",label:`Against ${l.iterations.toLocaleString()} shuffles of the ${g} set`,columns:[{key:"measure",label:"Measure",kind:"text"},{key:"observed",label:"Observed",kind:"number",digits:4},{key:"expected",label:"Expected",kind:"number",digits:4,hint:"Mean of the null."},{key:"fold",label:"Fold",kind:"number",digits:2,hint:"Observed over expected."},{key:"z",label:"z",kind:"number",digits:2},{key:"p",label:"p",kind:"number",digits:5,hint:`Permutation p on the tail the observation fell on, with Phipson and Smyth’s +1: the smallest this run can report is ${(1/(l.iterations+1)).toPrecision(2)}.`},{key:"tail",label:"Tail",kind:"text"}],rows:h}),i},Jt={maxIter:3e3,convergenceEps:1e-6,start:[.1,1,.2,.5],pseudoValueEps:1e-8,finalPseudoValueEps:1e-12,emStepsPerRound:30},Ct=[0,.2,.1,.01],ee=[20,20,.99,.99],Kr={min:Ct,max:ee};class se extends Error{constructor(e){super(e),this.name="IdrError"}}const In=new Float64Array(1),qr=new Int32Array(In.buffer),ca=new Uint8Array(Float64Array.of(1).buffer)[7]===63?1:0,GI=1-ca,Hr=.8450629115104675,xI=.1283791670955126,vI=1.0270333367641007,Fe=[.12837916709551256,-.3250421072470015,-.02848174957559851,-.005770270296489442,-23763016656650163e-21],Se=[.39791722395915535,.0650222499887673,.005081306281875766,.00013249473800432164,-3960228278775368e-21],zt=[-.0023621185607526594,.41485611868374833,-.3722078760357013,.31834661990116175,-.11089469428239668,.035478304325618236,-.002166375594868791],le=[.10642088040084423,.540397917702171,.07182865441419627,.12617121980876164,.01363708391202905,.011984499846799107],Tt=[-.009864944034847148,-.6938585727071818,-10.558626225323291,-62.375332450326006,-162.39666946257347,-184.60509290671104,-81.2874355063066,-9.814329344169145],$t=[19.651271667439257,137.65775414351904,434.56587747522923,645.3872717332679,429.00814002756783,108.63500554177944,6.570249770319282,-.0604244152148581],Xt=[-.0098649429247001,-.799283237680523,-17.757954917754752,-160.63638485582192,-637.5664433683896,-1025.0951316110772,-483.5191916086514],Vt=[30.33806074348246,325.7925129965739,1536.729586084437,3199.8582195085955,2553.0504064331644,474.52854120695537,-22.44095244658582];function 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dn(t,e,n,A){const s=(t-e)/n;return .5*A*Wr(s/Math.SQRT2)+.5*(1-A)*Wr(t/Math.SQRT2)+.5}function Pr(t,e,n,A,s,r,o){let i=0;for(let a=0;a<1e3;a++){i=s+(r-s)/2;const c=dn(i,e,n,A);if(Math.abs(c-t)<o)return i;c<t?s=i:r=i}return i}function UA(t,e,n,A,s,r){const o=Xr(t.length,n,A,s,r),i=e.length===t.length?o:Xr(e.length,n,A,s,r);return[zr(t,o),zr(e,i)]}function zr(t,e){const n=new Float64Array(t.length);for(let A=0;A<t.length;A++)n[A]=e[t[A]];return n}function Xr(t,e,n,A,s){const r=new Float64Array(t);if(t===0)return r;const o=t+1,i=1/o;let a=0<=e?0:e;for(;dn(a,e,n,A)>i;)a-=1;let c=0>=e?0:e;for(;dn(c,e,n,A)<1-i;)c+=1;a=Pr(i,e,n,A,a,c,s),r[0]=a;for(let l=1;l<t;l++){const g=(l+1)/o;dn(c,e,n,A)<g&&(c+=10);const f=Pr(g,e,n,A,a,c,s);r[l]=f,a=f,c=a+2*(f-r[l-1])}return r}class la{constructor(e,n){this.z1=e,this.z2=n,this.n=e.length,this.noise=new Float64Array(this.n),this.signal=new Float64Array(this.n),this.terms=new 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d=A[I]-l;i[I]=r[I]*(d*d)}const g=Bt(i);for(let I=0;I<n;I++){const d=s[I]-l;i[I]=r[I]*(d*d)}const f=Bt(i),h=Math.sqrt((g+f)/(2*o));for(let I=0;I<n;I++)i[I]=r[I]*(A[I]-l)*(s[I]-l);const u=2*Bt(i)/(g+f);return[l,h,u,o/n]}function ga(t){const e=[t[0],t[1],t[2],t[3]];let n=!1;return e[0]<Ct[0]&&(e[0]=Ct[0],n=!0),e[1]<Ct[1]&&(e[1]=Ct[1],n=!0),e[2]<Ct[2]?(e[2]=Ct[2],n=!0):e[2]>ee[2]&&(e[2]=ee[2],n=!0),e[3]<Ct[3]?(e[3]=Ct[3],n=!0):e[3]>ee[3]&&(e[3]=ee[3],n=!0),{theta:e,changed:n}}function TI(t,e,n,A){let s=e,r=t.logLik(s),o=[e[0],e[1],e[2],e[3]];for(let i=0;i<n;i++){const a=ga(UI(t,s));o=a.theta;const c=t.logLik(o);if(a.changed)return{theta:o,changed:!0};if(!(c+1e-6>=r))throw new se("An EM step lowered the likelihood, which stops idr’s own fit.");if(c-r<A)return{theta:o,changed:!1};s=o,r=c}return{theta:o,changed:!1}}function $I(t,e,n,A=1e-5,s=500){if(!Number.isFinite(e)||!Number.isFinite(n))throw new se("Optimization bounds must be finite scalars.");if(e>n)throw new se("The lower bound exceeds 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a>i?(e[n]+=o,a):i}function OI(t,e,n,A){let s=t.logLik(e),r=[e[0],e[1],e[2],e[3]],o=s;for(let i=0;i<n;i++){for(let c=0;c<4;c++)o=JI(t,r,c);const a=ga(r);if(a.changed)throw new se("Coordinate ascent left idr’s parameter box, which stops idr’s own fit.");if(r=a.theta,!(o+1e-6>=s))throw new se("A coordinate-ascent round lowered the likelihood, which stops idr’s own fit.");if(o-s<A)return r;s=o}return r}async function YI(t,e,n={}){const A=n.eps??Jt.convergenceEps,s=n.maxIter??Jt.maxIter,r=Jt.pseudoValueEps,o=n.start??Jt.start;let i=[o[0],o[1],o[2],o[3]],[a,c]=UA(t,e,i[0],i[1],i[3],r),l=!1,g=0;const f=new Float64Array(t.length);for(let h=0;h<s;h++){g=h+1;const u=i,I=new la(a,c),d=TI(I,u,Jt.emStepsPerRound,A/10);i=d.theta,d.changed&&(l=!0,i=OI(I,u,Jt.emStepsPerRound,A/10));const C=Bt([Math.abs(i[0]-u[0]),Math.abs(i[1]-u[1]),Math.abs(i[2]-u[2]),Math.abs(i[3]-u[3])]),B=a,Q=c;[a,c]=UA(t,e,i[0],i[1],i[3],r);for(let p=0;p<f.length;p++)f[p]=Math.abs(B[p]-a[p]);const E=RA(f);for(let 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Float64Array(Math.max(0,s-A));if(o===void 0)to(t,e,a,A,s,c,A);else{let l=0;for(;l<c.length;){const g=o.indexOf(1,l),f=g<0||g>c.length?c.length:g;if(c.fill(Number.NaN,l,f),f===c.length)break;const h=o.indexOf(0,f),u=h<0||h>c.length?c.length:h;to(t,e,a,A+f,A+u,c,A),l=u}}if(r!==void 0)for(let l=0;l<t.length;l++){const g=Math.max(A,t.starts[l]-a+i-1),f=Math.min(s-1,t.ends[l]-a-1);g<=f&&r.fill(1,g-A,f-A+1)}return c}function to(t,e,n,A,s,r,o){const i=e.values.length,a=e.values,c=e.cumulative,l=t.starts,g=t.ends,f=t.values,h=A+n+1,u=s+n,I=-(n+1)-o;let d=0,C=t.length;for(;d<C;){const E=d+C>>>1;g[E]>h-i?C=E:d=E+1}const B=c[0],Q=c[i];for(;d<t.length;d++){const E=l[d];if(E+1>u)break;const m=g[d],p=f[d];let w=E+1>h?E+1:h,y=m-1<E+i?m-1:E+i;if(y>u&&(y=u),w<=y){let k=w;k===E+1&&(r[I+k]+=p*a[0],k++);for(let b=I+k,M=k-E,F=I+y;b<=F;b++,M++)r[b]+=p*(c[M]-B)}if(w=m>h?m:h,y=E+i<u?E+i:u,w<=y)if(m-E===1)for(let k=I+w,b=w-1-E,M=I+y;k<=M;k++,b++)r[k]+=p*a[b];else for(let k=I+w,b=w-E,M=w-m,F=I+y;k<=F;k++,b++,M++)r[k]+=p*(c[b]-c[M]);if(w=E+i+1>h?E+i+1:h,y=m-1<u?m-1:u,w<=y){const k=p*(Q-B);for(let b=I+w,M=I+y;b<=M;b++)r[b]+=k}w=m>E+i+1?m:E+i+1,w<h&&(w=h);const N=m+i-1;if(y=N<u?N:u,w<=y){const k=I+(y===N?y-1:y);for(let b=I+w,M=w-m;b<=k;b++,M++)r[b]+=p*(Q-c[M]);y===N&&(r[I+N]+=p*a[i-1])}}}const td=65536;function ha(t){return Math.fround(t)<WI}function ed(t){const e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)ha(t[n])&&(e[n]=1);return e}class eo{constructor(e,n,A){this.contig=e,this.length=n,this.tracks=A.length,this.absent=A,this.scores=A.map(()=>[]),this.held=A.map(()=>new Float64Array(1024))}tracks;absent;starts=[];ends=[];modes=[];flats=[];scores;previous=!1;rose=!1;open=-1;best=Number.NEGATIVE_INFINITY;ties=[];held;heldLength=0;openFlat=0;position=0;feed(e,n,A,s){if(e!==this.position)throw new Error(`ConcaveScan: fed ${e} after ${this.position}`);for(let r=0;r<n.length;r++){const o=e+r,i=Math.fround(n[r]),a=ha(i);if(o===0?a&&this.begin(0):a&&!this.previous?(this.rose=!0,this.begin(o)):!a&&this.previous&&this.close(o),a){const c=-i;c>this.best?(this.best=c,this.ties=[o]):c===this.best&&this.ties.push(o),this.hold(A,r),s!==void 0&&s[r]===1&&(this.openFlat=1)}this.previous=a}this.position=e+n.length}finish(){if(this.open>=0&&this.close(this.length),!this.rose){this.starts=[],this.ends=[],this.modes=[],this.flats=[];for(const e of this.scores)e.length=0}return{contig:this.contig,starts:Int32Array.from(this.starts),ends:Int32Array.from(this.ends),modes:Int32Array.from(this.modes),scores:this.scores.map(e=>Float64Array.from(e)),flat:Uint8Array.from(this.flats)}}begin(e){this.open=e,this.best=Number.NEGATIVE_INFINITY,this.ties=[],this.heldLength=0,this.openFlat=0,this.held[0].length>td&&(this.held=this.held.map(()=>new Float64Array(1024)))}hold(e,n){this.heldLength===this.held[0].length&&(this.held=this.held.map(A=>{const s=new Float64Array(A.length*2);return s.set(A),s}));for(let A=0;A<this.tracks;A++)this.held[A][this.heldLength]=e[A][n];this.heldLength++}close(e){this.starts.push(this.open),this.ends.push(e),this.flats.push(this.openFlat),this.modes.push(this.ties.length===0?this.open:this.ties[this.ties.length>>1]);for(let n=0;n<this.tracks;n++)this.scores[n].push(this.absent[n]?Number.NEGATIVE_INFINITY:-RA(this.held[n],0,this.heldLength));this.open=-1}}function nd(t){const e=t.length,n=Array.from({length:e},(r,o)=>o);n.sort((r,o)=>t[o]-t[r]||r-o);const A=new Float64Array(e);let s=0;for(;s<e;){let r=s+1;for(;r<e&&t[n[r]]===t[n[s]];)r++;const o=(s+1+r)/2;for(let i=s;i<r;i++)A[n[i]]=o;s=r}return A}function Ad(t,e,n,A,s){const r=e.length,o=new Float64Array(r).fill(Number.POSITIVE_INFINITY);for(const l of A){const g=nd(l);for(let f=0;f<r;f++)g[f]<o[f]&&(o[f]=g[f])}const i=(l,g)=>t[l]<t[g]?-1:t[l]>t[g]?1:e[l]-e[g]||n[l]-n[g],a=Array.from({length:r},(l,g)=>g);a.sort((l,g)=>o[l]-o[g]||i(l,g));const c=a.slice(0,Math.max(0,Math.min(r,s)));return c.sort(i),Int32Array.from(c)}class sd{constructor(e,n,A={}){this.tracks=e,this.limit=n,this.scores=Array.from({length:e},()=>new Float64Array(1024)),this.floor=new Float64Array(e).fill(Number.NEGATIVE_INFINITY),A.prune===!1&&(this.holdAll=!0),this.below=A.below===!0?new Float64Array(1024):null}size=0;contigs=[];starts=new Int32Array(1024);ends=new Int32Array(1024);modes=new Int32Array(1024);flats=new Uint8Array(1024);scores;floor;seen=0;dropped=0;holdAll=!1;below;belowSize=0;add(e,n){this.seen++;let A=this.holdAll;for(let r=0;r<this.tracks;r++){const o=e.scores[r][n];o!==o&&!this.holdAll&&(this.holdAll=!0,A=!0),o>=this.floor[r]&&(A=!0)}if(!A){this.drop(e.scores[0][n],e.flat[n]);return}this.size===this.starts.length&&this.grow();const s=this.size++;this.contigs[s]=e.contig,this.starts[s]=e.starts[n],this.ends[s]=e.ends[n],this.modes[s]=e.modes[n],this.flats[s]=e.flat[n];for(let r=0;r<this.tracks;r++)this.scores[r][s]=e.scores[r][n];!this.holdAll&&this.size>=2*this.tracks*this.limit+1024&&this.prune()}finish(){this.holdAll||this.prune();const e=this.size,n={contig:this.contigs.slice(0,e),starts:this.starts.slice(0,e),ends:this.ends.slice(0,e),modes:this.modes.slice(0,e),flat:this.flats.slice(0,e),scores:this.scores.map(A=>A.slice(0,e))};return{...n,tested:Ad(n.contig,n.starts,n.ends,n.scores,this.limit),below:this.below===null?new Float64Array(0):this.below.slice(0,this.belowSize),exact:!(this.holdAll&&this.dropped>0)}}prune(){if(this.seen<this.limit)return;const e=this.size;for(let A=0;A<this.tracks;A++){const s=this.scores[A].slice(0,e).sort();this.floor[A]=s[e-this.limit]}let n=0;for(let A=0;A<e;A++){let s=!1;for(let r=0;r<this.tracks;r++)this.scores[r][A]>=this.floor[r]&&(s=!0);if(!s){this.drop(this.scores[0][A],this.flats[A]);continue}if(n!==A){this.contigs[n]=this.contigs[A],this.starts[n]=this.starts[A],this.ends[n]=this.ends[A],this.modes[n]=this.modes[A],this.flats[n]=this.flats[A];for(let r=0;r<this.tracks;r++)this.scores[r][n]=this.scores[r][A]}n++}this.size=n,this.contigs.length=n}drop(e,n){if(this.dropped++,!(this.below===null||!(e>0)||n===1)){if(this.belowSize===this.below.length){const A=new Float64Array(this.below.length*2);A.set(this.below),this.below=A}this.below[this.belowSize++]=e}}grow(){const e=n=>{const A=new n.constructor(n.length*2);return A.set(n),A};this.starts=e(this.starts),this.ends=e(this.ends),this.modes=e(this.modes),this.flats=e(this.flats),this.scores=this.scores.map(e)}}function rd(t,e,n,A,s){return A>0?[Math.max(0,n-A),Math.min(s,n+A+1)]:[t,e]}function ua(t){return-(Math.log(t)/Math.log(10))}const Ia=[.001,.005,.01,.05,.1,.2],gA="0.05";function da(t){return typeof t.replicate=="string"&&t.replicate!==""}const od="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",id=8,ad=-1,cd=-2;let ge;function ld(){if(ge!==void 0)return ge;ge=null;try{if(typeof WebAssembly>"u")return null;const t=atob(od),e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)e[n]=t.charCodeAt(n);WebAssembly.validate(e)&&(ge=new WebAssembly.Module(e))}catch{ge=null}return ge}class $A extends Error{constructor(){super("The peak-calling kernel ran out of memory."),this.name="KernelMemoryError"}}class gd{size=0;starts=new Int32Array(1024);ends=new Int32Array(1024);modes=new Int32Array(1024);flats=new Uint8Array(1024);scores;constructor(e){this.scores=Array.from({length:e},()=>new Float64Array(1024))}take(e,n,A){if(A===0)return;for(;this.size+A>this.starts.length;)this.grow();const s=e.buffer,r=n.scan_region_capacity();this.starts.set(new Int32Array(s,n.scan_region_starts()>>>0,A),this.size),this.ends.set(new Int32Array(s,n.scan_region_ends()>>>0,A),this.size),this.modes.set(new Int32Array(s,n.scan_region_modes()>>>0,A),this.size),this.flats.set(new Uint8Array(s,n.scan_region_flats()>>>0,A),this.size);const o=n.scan_regions()>>>0;this.scores.forEach((i,a)=>i.set(new Float64Array(s,o+a*r*8,A),this.size)),this.size+=A}grow(){const e=n=>{const A=new n.constructor(n.length*2);return A.set(n),A};this.starts=e(this.starts),this.ends=e(this.ends),this.modes=e(this.modes),this.flats=e(this.flats),this.scores=this.scores.map(e)}}class bs{constructor(e,n,A,s){this.memory=e,this.exports=n,this.contig=A,this.tracks=s,this.collected=new gd(s)}collected;static open(e,n,A,s,r){const o=ld();if(o===null||s<1||s>id)return null;try{const i=new WebAssembly.Memory({initial:2}),c=new WebAssembly.Instance(o,{env:{memory:i}}).exports,l=e.values.length;if(c.scan_open(s,l,ks(e,A),A,r)!==0)return null;const g=c.scan_kernel()>>>0;return new Float64Array(i.buffer,g,l).set(e.values),new Float64Array(i.buffer,g+l*8,l+1).set(e.cumulative),new bs(i,c,n,s)}catch{return null}}window(e,n,A,s,r){let o=0;for(let i=0;i<this.tracks;i++){const a=r[i];if(a===null){o|=1<<i;continue}const c=a.starts.length,l=this.exports.scan_input(i,c)>>>0;if(l===0)throw new $A;const g=this.memory.buffer;new Float64Array(g,l,c).set(a.values),new Int32Array(g,l+c*8,c).set(a.starts),new Int32Array(g,l+c*12,c).set(a.ends)}this.closed(this.exports.scan_window(e,n,A,s,o),e)}lastWindow(e){const n=this.memory.buffer;return{pooled:new Float64Array(n,this.exports.scan_pooled()>>>0,e).slice(),flat:new Uint8Array(n,this.exports.scan_flat()>>>0,e).slice(),own:Array.from({length:this.tracks},(A,s)=>new Float64Array(n,this.exports.scan_own(s)>>>0,e).slice())}}finish(){this.closed(this.exports.scan_finish(),-1);const{collected:e}=this,n=this.exports.scan_rose()===1?e.size:0;return{contig:this.contig,starts:e.starts.slice(0,n),ends:e.ends.slice(0,n),modes:e.modes.slice(0,n),scores:e.scores.map(A=>A.slice(0,n)),flat:e.flats.slice(0,n)}}closed(e,n){if(e===ad)throw new $A;if(e===cd)throw new Error(`ConcaveScan: fed ${n} out of order`);if(e<0)throw new Error(`pooledRuns: a track does not cover a window at ${n}`);this.collected.take(this.memory,this.exports,e)}}const fA=1<<18,no=20,rn=2e4,Ao=["#0072b2","#009e73"],fd="#999999",hd=async t=>{const e=at(t.params,"signal");if(e===null)return t.note("No track was chosen. Load a bigWig and pick it under Track."),[];const n=da(t.params)?at(t.params,"replicate"):null;if(n===e)return t.note("The replicate chosen is the track being called, and a track cannot test itself. Choose a second track, or none."),[];const A=n===null?[e]:[e,n],s=L=>t.inputs.labels?.[L]??L,r=Re(T(t.params,"width",sn.width),1,2e3),o=Re(T(t.params,"times",sn.times),0,10),i=Re(T(t.params,"minWidth",sn.minWidth),1,1e9),a=Re(T(t.params,"halfWidth",0),0,1e9),c=Re(T(t.params,"truncate",sn.truncate),1,1e9),l=Id(t),g=t.inputs.contigLengths??{},f=Yn(t.params,"sequences"),h=Object.keys(g).filter(L=>g[L]>0&&(f===null||f.includes(L)));if(h.length===0)return t.note(f!==null&&f.length===0?"No sequence is ticked, so there is nothing to call peaks on.":"This session knows no sequence lengths, so there is nothing to scan. Load a chrom.sizes, or the map itself."),[];const u=PI(r,o),I=L=>ud(t,A,h,g,u,{minWidth:i,truncate:c,below:n===null,prune:L});let d=await I(!0);if(typeof d!="string"&&!d.held.exact&&(d=await I(!1)),typeof d=="string")return t.note(d),[];const{held:C,found:B,n:Q,perSequence:E,absentOn:m}=d;for(let L=0;L<A.length;L++){if(m[L].length===h.length)return t.note(`${s(A[L])} has none of the ${h.length===1?"sequence":"sequences"} ticked. Check that it and the assembly name their sequences the same way.`),[];m[L].length>0&&t.note(`${s(A[L])} has no ${pd(m[L])}. yapc reads a track that lacks a sequence as zeros there, so it lowers the mean the regions are called on, and ranks every region there last by it.`)}const p=`${u.values.length}-tap kernel: a ${r.toLocaleString()} bp window, ${o} ${o===1?"pass":"passes"}`;if(Q===0)return t.note(`No concave region at least ${i.toLocaleString()} bp wide on ${h.length===1?h[0]:`${h.length} sequences`} (${p}). A wider smoothing window finds broader shapes; a narrower minimum keeps smaller ones.`),[];const{contig:w,starts:y,ends:N,modes:k,flat:b,scores:M,tested:F}=C;t.note(`${B.toLocaleString()} concave ${B===1?"region":"regions"} on ${h.length.toLocaleString()} ${h.length===1?"sequence":"sequences"} (${p}), ${Q.toLocaleString()} at least ${i.toLocaleString()} bp wide`+(F.length<Q?`, of which the ${F.length.toLocaleString()} strongest by each track’s curvature rank were kept.`:"."));let S=null,v=null,G=null;const O=new Uint8Array(F.length).fill(1);if(n!==null)if(F.length<no)t.note(`IDR needs at least ${no} peaks to fit — its own command refuses fewer — and there ${F.length===1?"is 1":`are ${F.length}`}. They are reported untested, ranked by curvature.`);else{const L=Zr(on(M[0],F)),J=Zr(on(M[1],F)),Mt=oo(on(M[0],F))+oo(on(M[1],F));Mt>0&&t.note(`${Mt.toLocaleString()} ${Mt===1?"score ties":"scores tie"} with another: ranked by position, where yapc breaks a tie at random.`);try{S=await YI(L,J,{between:async P=>{t.progress(0,0,`IDR, round ${P}`),await Es(),t.throwIfCancelled()}})}catch(P){throw P instanceof se?new Error(`IDR could not fit these two tracks, as idr itself could not: ${P.message}`):P}v=_I(S.theta,L,J),G=KI(v);const vt=ua(l);for(let P=0;P<F.length;P++)O[P]=TA(G[P])>=vt?1:0;t.note(dd(S,F.length,md(O),l))}else{let L=0;for(let J=0;J<F.length;J++)b[F[J]]!==0&&(O[J]=0,L++);L>0&&t.note(`${L.toLocaleString()} of the candidates ${L===1?"is":"are"} flat — the signal constant across a whole kernel’s width inside, which yapc’s test counts as concave — and ${L===1?"is":"are"} left out, as IDR would leave ${L===1?"it":"them"} out of two replicates.`),t.note("One track, so no test of significance: yapc’s cut is IDR between two replicates. These are the strongest concave regions by curvature — choose a replicate to test them, or lower “keep the strongest” to the upper of the two populations in the figure.")}const $=new Map(h.map((L,J)=>[L,J])),K=[];for(let L=0;L<F.length;L++)O[L]===1&&K.push(L);K.sort((L,J)=>($.get(w[F[L]])??0)-($.get(w[F[J]])??0)||y[F[L]]-y[F[J]]);const V=new et;let H=0,ht=0;for(const L of K){const J=F[L],[Mt,vt]=rd(y[J],N[J],k[J],a,g[w[J]]);a>0&&(Mt!==k[J]-a||vt!==k[J]+a+1)&&H++;const P=[`summit ${(k[J]+1).toLocaleString("en-US")}`];P.push(`curvature ${A.map((qQ,ac)=>io(M[ac][J])).join(" / ")}`),G!==null&&P.push(`IDR ${io(G[L])}`),V.add(w[J],Mt,vt,{name:`peak_${++ht}`,score:G!==null?TA(G[L]):M[0][J],cds:[k[J],k[J]+1],detail:P.join(ct)})}H>0&&t.note(`${H.toLocaleString()} ${H===1?"peak reaches":"peaks reach"} past a sequence end at this half-width and ${H===1?"is":"are"} cut at it; yapc writes the coordinate past the end.`),K.length===0&&t.note(`No peak passes IDR ≤ ${l}. A looser threshold keeps more; two tracks that are not replicates of one experiment will pass few at any.`);const xt=[];K.length>0&&xt.push({kind:"intervals",id:`peaks-${A.map(L=>L.replace(/[^A-Za-z0-9_]+/g,"_")).join("-")}`,label:n===null?`Peaks · ${s(e)} · no IDR`:`Peaks · ${s(e)} + ${s(n)} · IDR ≤ ${l}`,payload:{kind:"features",data:V.finish()},noun:{one:"peak",many:"peaks"},lane:{under:{entry:e}},display:"lane",look:"point"});const q=Cd(A.map(s),M,F,O,n!==null,b,C.below);return q!==null&&xt.push(q),xt.push(Qd(h,g,E,K.map(L=>w[F[L]]))),S!==null&&G!==null&&xt.push(Bd(G,l)),Lt(t.params,"perPeak",!1)&&xt.push(Ed({names:A.map(s),contig:w,starts:y,ends:N,modes:k,scores:M,tested:F,passes:O,local:v,global:G,replicate:n!==null})),t.progress(1,1,"done"),xt};async function ud(t,e,n,A,s,r){const o=n.reduce((h,u)=>h+A[u],0);let i=0;const a=new sd(e.length,r.truncate,{prune:r.prune,below:r.below}),c=e.map(()=>[]),l=new Map;let g=0,f=0;for(const h of n){const u=await Ca(t,e,h,A[h],s,C=>{i+=C,t.progress(i,o,h)});if(typeof u=="string")return u;const{regions:I}=u;let d=0;for(let C=0;C<I.starts.length;C++)I.ends[C]-I.starts[C]<r.minWidth||(d++,a.add(I,C));g+=I.starts.length,f+=d,l.set(h,{regions:I.starts.length,wide:d}),u.absent.forEach((C,B)=>{C&&c[B].push(h)})}return{held:a.finish(),found:g,n:f,perSequence:l,absentOn:c}}async function Ca(t,e,n,A,s,r,o="auto"){const{left:i,right:a}=XI(s,A),c=e.map(()=>!1),l=o==="js"?null:bs.open(s,n,A,e.length,fA);let g=null,f=0;try{for(let h=0;h<A;h+=fA){const u=Math.min(A,h+fA),I=Math.max(0,h-i),d=Math.min(A,u+a),C=[];for(let B=0;B<e.length;B++){if(c[B]){C.push(null);continue}const Q=await t.sample(e[B],[{contig:n,start:I,end:d}],1);if(Q.note!==void 0)return Q.note;const E=Q.regions[0];E===void 0&&(c[B]=!0),C.push(E??null)}if(l!==null)l.window(h,u,I,d,C);else{const B=C.map(w=>w===null?ZI(I,d):VI(w.starts,w.ends,w.values,I,d));g??=new eo(n,A,c);const Q=new Uint8Array(u-h),E=jr(jI(B,I,d),s,A,h,u,Q),m=e.length===1?null:ed(E),p=m===null?[E]:B.map(w=>jr(w,s,A,h,u,void 0,m));g.feed(h,E,p,Q)}r(u-h),f+=u-h,await Es(),t.throwIfCancelled()}}catch(h){if(!(h instanceof $A))throw h;return r(-f),Ca(t,e,n,A,s,r,"js")}return l!==null?{regions:l.finish(),absent:c}:{regions:(g??new eo(n,A,c)).finish(),absent:c}}function Id(t){const e=Number(st(t.params,"idr",gA));return Ia.includes(e)?e:(da(t.params)&&t.note(`An IDR threshold of ${st(t.params,"idr","")} is not one yapc writes; ${gA} was used.`),Number(gA))}const so=["mean","spread","correlation","reproducible share"];function dd(t,e,n,A){const[s,r,o,i]=t.theta,a=`IDR fitted over ${e.toLocaleString()} peaks in ${t.rounds.toLocaleString()} rounds: μ ${s.toFixed(2)}, σ ${r.toFixed(2)}, ρ ${o.toFixed(2)}, reproducible share ${i.toFixed(2)}; ${n.toLocaleString()} pass IDR ≤ ${A}.`,c=[],l=g=>Number.isInteger(g)?String(g):g.toFixed(2);return t.theta.forEach((g,f)=>{const[h,u]=[Kr.min[f],Kr.max[f]];g<=h+1e-4*Math.max(1,h)?c.push(`the ${so[f]} at its floor of ${l(h)}`):g>=u-1e-4*Math.max(1,u)&&c.push(`the ${so[f]} at its ceiling of ${l(u)}`)}),c.length===0?a:`${a} The fit ended at the edge of IDR’s parameter box — ${c.join(", ")} — which is where two tracks that do not rank their peaks like replicates of one experiment put it. Read these IDRs as that, not as reproducibility.`}function Cd(t,e,n,A,s,r,o){const i=[],a=new Uint8Array(r.length);for(const f of n)a[f]=1;for(let f=0;f<e.length;f++){const h=[],u=[];if(n.forEach((B,Q)=>{const E=e[f][B];!(E>0)||!s&&r[B]===1||(A[Q]===1?h.push(E):u.push(E))}),!s){for(let B=0;B<r.length;B++)a[B]===0&&e[f][B]>0&&r[B]===0&&u.push(e[f][B]);for(const B of o)u.push(B)}const I=e.length===1?"":`${t[f]} · `,d=s?`${I}passes IDR`:`${I}peaks`,C=s?`${I}fails IDR`:`${I}below the cut`;h.length>0&&i.push(ro(d,h,Ao[f]??Ao[0])),u.length>0&&i.push(ro(C,u,fd))}if(i.length===0)return null;const c=i.flatMap(f=>Array.from(f.y)),l=wd(c,.01);let g=Number.NEGATIVE_INFINITY;for(const f of c)f>g&&(g=f);return{kind:"curve",id:"peaks-curvature",label:"Curvature of every candidate",series:i,xLabel:"",yLabel:"Curvature (yapc score)",xScale:"linear",yScale:"log",...Number.isFinite(l)&&l>0&&g>l?{yDomain:[10**Math.floor(Math.log10(l)),10**Math.ceil(Math.log10(g))]}:{}}}function ro(t,e,n){const A=Float64Array.from(e).sort();let s=A;if(A.length>rn){s=new Float64Array(rn);for(let r=0;r<rn;r++)s[r]=A[Math.round(r*(A.length-1)/(rn-1))]}return{name:t,x:Float64Array.from(s,(r,o)=>o),y:s,colour:n,n:e.length,mark:"violin"}}function Qd(t,e,n,A){const s=new Map;for(const r of A)s.set(r,(s.get(r)??0)+1);return{kind:"table",id:"peaks-sequences",label:"Per sequence",columns:[{key:"sequence",label:"Sequence",kind:"text"},{key:"length",label:"Length",kind:"number"},{key:"regions",label:"Concave regions",kind:"number"},{key:"wide",label:"Wide enough",kind:"number"},{key:"peaks",label:"Peaks",kind:"number"},{key:"density",label:"Peaks per Mb",kind:"number",digits:1}],rows:t.map(r=>{const o=n.get(r)??{regions:0,wide:0},i=s.get(r)??0;return{sequence:r,length:e[r],regions:o.regions,wide:o.wide,peaks:i,density:i/e[r]*1e6}})}}function Bd(t,e){const n=t.length;return{kind:"table",id:"peaks-idr",label:"IDR thresholds",columns:[{key:"threshold",label:"IDR ≤",kind:"text"},{key:"peaks",label:"Peaks",kind:"number"},{key:"share",label:"Share of tested",kind:"number",digits:3},{key:"drawn",label:"Drawn",kind:"text"}],rows:Ia.map(A=>{const s=ua(A);let r=0;for(let o=0;o<n;o++)TA(t[o])>=s&&r++;return{threshold:String(A),peaks:r,share:r/n,drawn:A===e?"yes":""}})}}function Ed(t){const{names:e,contig:n,starts:A,ends:s,modes:r,scores:o,tested:i,passes:a,local:c,global:l}=t,g=[];return i.forEach((f,h)=>{const u={sequence:n[f],start:A[f],end:s[f],summit:r[f],width:s[f]-A[f]};o.forEach((I,d)=>{u[`curvature${d}`]=I[f]}),c!==null&&l!==null&&(u.local=c[h],u.idr=l[h],u.passes=a[h]===1?"yes":"no"),g.push(u)}),l!==null?g.sort((f,h)=>Number(f.idr)-Number(h.idr)):g.sort((f,h)=>Number(h.curvature0)-Number(f.curvature0)),{kind:"table",id:"peaks-list",label:t.replicate?"Every peak tested":"Every peak",columns:[{key:"sequence",label:"Sequence",kind:"text"},{key:"start",label:"Start",kind:"number",coordinate:"start"},{key:"end",label:"End",kind:"number",coordinate:"end"},{key:"summit",label:"Summit",kind:"number",coordinate:"start",hint:"The most concave base."},{key:"width",label:"Width",kind:"number"},...e.map((f,h)=>({key:`curvature${h}`,label:e.length===1?"Curvature":`Curvature · ${f}`,kind:"number",digits:2})),...c!==null?[{key:"local",label:"Local IDR",kind:"number",digits:4,scientific:!0},{key:"idr",label:"IDR",kind:"number",digits:4,scientific:!0},{key:"passes",label:"Passes",kind:"text"}]:[]],rows:g}}function Re(t,e,n){return Math.min(n,Math.max(e,Math.round(t)))}function on(t,e){const n=new Float64Array(e.length);for(let A=0;A<e.length;A++)n[A]=t[e[A]];return n}function md(t){let e=0;for(const n of t)e+=n;return e}function oo(t){const e=Float64Array.from(t).sort();let n=0;for(let A=1;A<e.length;A++)e[A]===e[A-1]&&n++;return n}function wd(t,e){if(t.length===0)return Number.NaN;const n=Float64Array.from(t).sort(),A=e*(n.length-1),s=Math.floor(A),r=Math.min(n.length-1,s+1);return n[s]+(A-s)*(n[r]-n[s])}function io(t){return Number.isFinite(t)?Number(t.toPrecision(4)).toLocaleString("en-US",{maximumSignificantDigits:4}):t>0?"∞":t<0?"−∞":"—"}function pd(t){return t.length===1?t[0]:t.length<=3?`${t.slice(0,-1).join(", ")} and ${t[t.length-1]}`:`${t.slice(0,3).join(", ")} and ${(t.length-3).toLocaleString()} more`}const Qa=[{name:"DpnII",site:"GATC",cut:0},{name:"HindIII",site:"AAGCTT",cut:1},{name:"NcoI",site:"CCATGG",cut:1},{name:"EcoRI",site:"GAATTC",cut:1},{name:"BglII",site:"AGATCT",cut:1},{name:"HinfI",site:"GANTC",cut:1},{name:"DdeI",site:"CTNAG",cut:1},{name:"MseI",site:"TTAA",cut:1},{name:"NlaIII",site:"CATG",cut:4},{name:"CviQI",site:"GTAC",cut:1},{name:"AluI",site:"AGCT",cut:2}],yd={MboI:"DpnII",Sau3AI:"DpnII",Csp6I:"CviQI"},Sn={Arima:["DpnII","HinfI"]},Nd=(()=>{const t=new Map;for(const e of Qa)t.set(e.name.toLowerCase(),e);for(const[e,n]of Object.entries(yd)){const A=t.get(n.toLowerCase());A!==void 0&&t.set(e.toLowerCase(),A)}return t})();function an(t){return Nd.get(t.trim().toLowerCase())}function Rn(t){const e=t.trim().toLowerCase();return Object.keys(Sn).find(n=>n.toLowerCase()===e)}function Ba(t){return`${t.site.slice(0,t.cut)}^${t.site.slice(t.cut)}`}function kd(t){return t.site.length-2*t.cut}const bd=1/256,ao=255;function co(t){let e=1;for(const n of t){let A=0;for(let s=n;s!==0;s&=s-1)A++;e*=A/4}return e}function Md(t){const e=t.toUpperCase().replace(/U/g,"T"),n=e.indexOf("^"),A=e.replace("^","");if(n<0){const r=Ye(A);return{refusal:Oe(r)?`“${t}” is neither an enzyme this knows nor a site in IUPAC letters with a ^ where it cuts.`:`“${t}” needs a ^ where the enzyme cuts the top strand, as in ^GATC or G^ANTC.`}}if(A.includes("^"))return{refusal:`“${t}” has more than one ^, and a site is cut in one place.`};const s=Ye(A);return Oe(s)?{refusal:s.reason}:co(s)>bd?{refusal:`“${t}” would cut every ${Math.round(1/co(s))} bases or so; a site needs at least the specificity of a four-base cutter.`}:{name:`${e.slice(0,n)}^${e.slice(n+1)}`,site:A,cut:n}}function Dd(t,e){const n=t.trim();if(n===""||n==="none")return[];if(n!=="custom"){const i=Rn(n);if(i!==void 0)return Sn[i].map(c=>an(c));const a=an(n);return a===void 0?{refusal:`“${n}” is not an enzyme or a kit this knows. Pick one, or type its site under custom.`}:[a]}const A=e.split(/[\s,;]+/).filter(i=>i!=="");if(A.length===0)return{refusal:"Type an enzyme or a site, such as DpnII or G^ANTC."};const s=[],r=new Set,o=i=>{const a=`${i.site}^${i.cut}`;r.has(a)||(r.add(a),s.push(i))};for(const i of A){const a=Rn(i);if(a!==void 0){for(const g of Sn[a])o(an(g));continue}const c=an(i);if(c!==void 0){o(c);continue}const l=Md(i);if("refusal"in l)return l;o(l)}return s.length>ao?{refusal:`That is ${s.length} enzymes, and one digest takes ${ao} at most.`}:s}function Fd(t){return t.map(e=>e.name).join("+")}function Sd(t){let e=0;for(const n of t)e=Math.max(e,n.site.length);return Math.max(0,e-1)}const lo=new Map;function Rd(t){const e=`${t.site}^${t.cut}`,n=lo.get(e);if(n!==void 0)return n;const A=Ye(t.site);if(Oe(A))throw new Error(`${t.name}: ${A.reason}`);const s={motif:A,offset:t.cut};return lo.set(e,s),s}const Qe=256;function Ea(t,e,n,A,s){const r=t.subarray(0,e).sort();let o=0,i=Number.NaN;for(let c=0;c<r.length;c++){const l=Math.floor(r[c]/Qe);l===i||!(l>A&&l<s)||(i=l,r[o++]=r[c])}const a={top:new Int32Array(o),bottom:new Int32Array(o),enzyme:new Uint8Array(o)};for(let c=0;c<o;c++){const l=Math.floor(r[c]/Qe),g=r[c]-l*Qe;a.top[c]=l,a.bottom[c]=l+n[g],a.enzyme[c]=g}return a}function Ld(t,e,n=0){let A=new Float64Array(Math.max(16,t.length>>7)),s=0;e.forEach((o,i)=>{const a=Rd(o),{hits:c}=ys(t,a.motif,{bothStrands:!0,offset:n});if(s+c.length>A.length){const l=new Float64Array(Math.max(A.length*2,s+c.length));l.set(A.subarray(0,s)),A=l}for(const l of c)A[s++]=(l.start+a.offset)*Qe+i});const r=Int32Array.from(e,kd);return Ea(A,s,r,Number.NEGATIVE_INFINITY,Number.POSITIVE_INFINITY)}function Gd(t,e){let n=0;for(const o of t)n+=o.top.length;const A=new Float64Array(n),s=new Int32Array(Qe);let r=0;for(const o of t)for(let i=0;i<o.top.length;i++)A[r++]=o.top[i]*Qe+o.enzyme[i],s[o.enzyme[i]]=o.bottom[i]-o.top[i];return Ea(A,r,s,0,e)}const xd=16e6;[...Qa.map(t=>({value:t.name,label:`${t.name} (${Ba(t)})`})),...Object.entries(Sn).map(([t,e])=>({value:t,label:`${t} (${e.join(" + ")})`}))];function vd(t){const e=typeof t.enzyme=="string"?t.enzyme:"none",n=typeof t.sites=="string"?t.sites:"";return{choice:e,sites:n}}async function Ud(t,e,n={}){const A=n.contigs??t.contigs,s=Sd(e),r=Math.max(1,Math.floor(n.piece??xd)),o=t.read?.bind(t),i=A.reduce((l,g)=>l+g.length,0);let a=0;const c=[];for(const l of A){const g=o===void 0?t.bases(l.name):void 0;if(o===void 0&&g===void 0)continue;const f=g?.length??l.length,h=[];let u=!0;for(let I=0;I<f;I+=r){n.throwIfCancelled?.();const d=Math.min(f,I+r),C=Math.min(f,d+s),B=g!==void 0?g.subarray(I,C):await o?.(l.name,I,C);if(B===void 0){u=!1;break}h.push(Ld(B,e,I)),a+=d-I,n.progress?.(a,i,l.name)}u&&c.push({contig:l.name,length:f,cuts:Gd(h,f)})}return c}function Td(t,e){const n=Fd(e),A=Rn(t);return A===void 0?n:`${A} (${n})`}function $d(t,e){const n=Rn(t);return n!==void 0?n.replace(/[^A-Za-z0-9]/g,""):e.map(A=>A.name.replace(/\^/g,"_").replace(/[^A-Za-z0-9_]/g,"")).join("-")}const Jd=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to cut."),[];if(e===null)return t.note("No reference was chosen. Load a FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.read===void 0&&n.refusal!==void 0)return t.note(n.refusal),[];const{choice:A,sites:s}=vd(t.params),r=Dd(A,s);if(!Array.isArray(r))return t.note(r.refusal),[];if(r.length===0)return t.note("No enzyme was chosen, so there is nothing to cut."),[];const o=Yn(t.params,"sequences");if(o!==null&&o.length===0)return t.note("No sequence is ticked, so there is nothing to cut."),[];const i=Object.entries(t.inputs.contigLengths??{}).filter(([,E])=>E>0).map(([E])=>E),a=Aa(n,o,i);if(a.length===0)return t.note("None of the ticked sequences is in this reference, so there is nothing to cut."),[];const c=a.length===n.contigs.length;t.progress(0,1,a.length===1?`cutting ${a[0].name}`:`cutting ${a.length.toLocaleString()} sequences`);const l=await Ud(n,r,{contigs:a,progress:(E,m,p)=>t.progress(E,m,`cutting ${p}`),throwIfCancelled:()=>t.throwIfCancelled()});if(t.progress(1,1,"done"),l.length===0)return t.note("None of the ticked sequences could be read from this reference."),[];const g=Td(A,r),f=c?g:a.length<=3?`${g} on ${a.map(E=>E.name).join(", ")}`:`${g} on ${a.length.toLocaleString()} sequences`;let h=0,u=0;for(const E of l)h+=E.cuts.top.length,u+=E.length;const I=h+l.length;t.note(h===0?`No ${g} site anywhere in ${c?"this reference":"the sequences ticked"}, so each sequence is one fragment.`:`${h.toLocaleString()} ${g} ${h===1?"cut":"cuts"} on ${l.length.toLocaleString()} ${l.length===1?"sequence":"sequences"}: ${I.toLocaleString()} fragments, ${Math.round(u/I).toLocaleString()} bp long on average.`);const d=`restriction-${$d(A,r)}${c?"":Od(a)}`,C=Yd(l,r),B=[_d(C,f,d)],Q=Kd(t,C,f,d);return Q!==null&&B.push(Q),B};function Od(t){const e=t.map(A=>A.name);if(e.length<=3)return`-on-${e.map(A=>A.replace(/[^A-Za-z0-9]/g,"")).join("-")}`;let n=5381;for(const A of e.join(`
+`))n=(n*33^A.charCodeAt(0))>>>0;return`-on${e.length}-${n.toString(36)}`}function Yd(t,e){let n=0;for(const i of t)n+=i.cuts.top.length;const A=e.map(i=>i.name),s=e.map(i=>`${i.name} cuts ${Ba(i)}`),r={contigs:t.map(i=>i.contig),length:n,contig:new Int32Array(n),start:new Int32Array(n),end:new Int32Array(n),strand:new Int8Array(n),score:new Float32Array(n).fill(Number.NaN),name:new Array(n),id:new Array(n).fill(""),detail:new Array(n),exonAt:new Int32Array(n+1),exonStart:new Int32Array(0),exonEnd:new Int32Array(0),cdsStart:new Int32Array(n).fill(-1),cdsEnd:new Int32Array(n).fill(-1),contigAt:new Int32Array(t.length+1),maxSpan:new Int32Array(t.length)};let o=0;return t.forEach((i,a)=>{const{top:c,enzyme:l}=i.cuts;r.contigAt[a]=o,r.contig.fill(a,o,o+c.length),r.start.set(c,o);for(let g=0;g<c.length;g++)r.end[o+g]=c[g]+1,r.name[o+g]=A[l[g]],r.detail[o+g]=s[l[g]];c.length>0&&(r.maxSpan[a]=1),o+=c.length}),r.contigAt[t.length]=o,r}function _d(t,e,n){return{kind:"intervals",id:n,label:`${e} sites`,payload:{kind:"features",data:t},noun:{one:"site",many:"sites"},display:"lane",look:"point"}}function Kd(t,e,n,A){const s=t.framing.binsize,r=Kn(t);if(!(s>0)||r.length===0)return t.note("The sites are a lane; the density is not. A per-bin track needs the bin grid of an open contact map, and this session has none. Open the map and run it again for that half."),null;const o=e.contigs.map((a,c)=>{const l=e.contigAt[c],g=e.contigAt[c+1];return{contig:a,starts:e.start.subarray(l,g),ends:e.end.subarray(l,g),strands:e.strand.subarray(l,g)}}),i=na({hits:o,total:e.length},r,s);return{kind:"profile",id:`${A}-density`,label:`${n} site density`,values:i.values,extent:[0,i.values.length],binsize:s,unit:"sites"}}const qd=async t=>{const e=On(t.params,"tracks");if(e.length<2)return t.note(e.length===0?"No tracks were chosen. Load two or more bigWigs and tick them under Tracks.":"Only one track was chosen, and a correlation needs two."),[];const n=I=>t.inputs.labels?.[I]??I,A=e.map(n),s=await Hd(t);if(s.count===0)return t.note("No unit to compare over. Check that the tracks and the assembly share contig names."),[];const r=[];for(let I=0;I<e.length;I++)t.throwIfCancelled(),t.progress(I,e.length,A[I]),r.push(await Pd(t,e[I],s));t.progress(e.length,e.length,"correlating");const o=zd(r),i=s.kind==="bins"?"windows":"features";if(o<bn)t.note(`Fewer than ${bn} of the ${s.count.toLocaleString()} ${i} have a value in every track, so no pair has a coefficient. Check that the tracks cover the same sequences.`);else if(o<s.count){const I=s.count-o,d=I===1;t.note(`${I.toLocaleString()} of the ${s.count.toLocaleString()} ${i} ${d?"has":"have"} no value in at least one track, and ${d?"is":"are"} left out of every pair: every coefficient is over the other ${o.toLocaleString()}.`)}const a=st(t.params,"method","spearman"),c=e.length,l=new Float32Array(c*c),g=[];for(let I=0;I<c;I++){l[I*c+I]=1;for(let d=I+1;d<c;d++){const C=a==="pearson"?_i(r[I],r[d]):Uh(r[I],r[d]);l[I*c+d]=C,l[d*c+I]=C,g.push({a:A[I],b:A[d],r:C})}}const f={kind:"matrix",id:"trackcorr",label:`Track correlation · ${a}`,nrows:c,ncols:c,values:l,xLabel:"",yLabel:"",xTicks:A,yTicks:A,colormap:Fl,centre:0,stats:[{label:"units",value:s.count,digits:0},{label:"compared",value:o,digits:0,hint:"Units every track has a value for: the ones every pair is correlated over."}]},h={kind:"table",id:"trackcorr-table",label:"Pairs",columns:[{key:"a",label:"Track",kind:"text"},{key:"b",label:"Track",kind:"text"},{key:"r",label:a==="pearson"?"Pearson r":"Spearman ρ",kind:"number",digits:3}],rows:g.sort((I,d)=>Number(d.r)-Number(I.r))};return[f,h]};async function Hd(t){if(st(t.params,"over","bins")==="features"){const s=ne(t.inputs.features,t.params,"features"),r=s.value;if(r===void 0)return t.note(_n(s,{unchosen:"Correlating over features needs a feature set, and none was chosen.",gone:"The feature set chosen is no longer loaded. Re-open the file, or pick another."})??""),{kind:"features",regions:[],count:0};const o=[];for(let i=0;i<r.length;i++)o.push({contig:r.contigs[r.contig[i]],start:r.start[i],end:r.end[i]});return{kind:"features",regions:o,count:o.length}}const e=Math.max(1,Math.round(T(t.params,"binsize",100))),n=[];let A=0;for(const[s,r]of Object.entries(t.inputs.contigLengths??{})){const o=Math.floor(r/e);o!==0&&(n.push({contig:s,count:o,offset:A}),A+=o)}return{kind:"bins",size:e,tilings:n,count:A}}const Wd=1<<20,go=4096;async function Pd(t,e,n){const A=new Float64Array(n.count),s=new Float64Array(n.count),r=(o,i,a,c,l,g)=>{const f=Math.min(l,a)-Math.max(c,i);f>0&&(A[o]+=g*f,s[o]+=f)};if(n.kind==="bins"){const{size:o}=n,i=Math.max(1,Math.floor(Wd/o))*o;for(const a of n.tilings){const c=a.count*o;for(let l=0;l<c;l+=i){t.throwIfCancelled();const g=Math.min(c,l+i),f=await t.sample(e,[{contig:a.contig,start:l,end:g}],1);for(const h of f.regions)for(let u=0;u<h.values.length;u++){const I=h.values[u];if(!Number.isFinite(I))continue;const d=Math.max(l,h.starts[u]),C=Math.min(g,h.ends[u]);for(let B=Math.floor(d/o);B*o<C;B++)r(a.offset+B,B*o,(B+1)*o,d,C,I)}}}}else{const o=new Map;n.regions.forEach((i,a)=>{const c=o.get(i.contig);c===void 0?o.set(i.contig,[a]):c.push(a)});for(const[,i]of o)for(let a=0;a<i.length;a+=go){t.throwIfCancelled();const c=i.slice(a,a+go),l=await t.sample(e,c.map(f=>n.regions[f]),1),g=new Map;for(const f of l.regions)g.set(`${f.contig}:${f.start}-${f.end}`,f);for(const f of c){const h=n.regions[f],u=g.get(`${h.contig}:${h.start}-${h.end}`);if(u!==void 0)for(let I=0;I<u.values.length;I++){const d=u.values[I];Number.isFinite(d)&&r(f,h.start,h.end,u.starts[I],u.ends[I],d)}}}}for(let o=0;o<A.length;o++)A[o]=s[o]>0?A[o]/s[o]:Number.NaN;return A}function zd(t){const e=t.length===0?0:t[0].length;let n=0;for(let A=0;A<e;A++)if(t.every(s=>!Number.isNaN(s[A])))n++;else for(const s of t)s[A]=Number.NaN;return n}const Xd={motif:Ou,restriction:Jd,peaks:hd,composition:eI,dotplot:CI,oriter:DI,metaplot:wu,trackcorr:qd,frip:Jh,groupsignal:nu,overlap:LI},Vd="0.20.0",Zd="40ec1ec";function jd(t){const e=[],n=new Set;for(const A of t.split(/\r?\n/)){const s=A.trim();if(s===""||s.startsWith("#"))continue;const r=s.split(/\s+/);if(r.length<5)return[];const[o,i,a,c,l]=[r[0],Number(r[1]),Number(r[2]),Number(r[3]),Number(r[4])];if([i,a,c,l].some(f=>!Number.isInteger(f)||f<0))return[];if(c===0||l<c)return[];n.has(o)||(n.add(o),e.push({name:o,length:i,offset:a,lineBases:c,lineWidth:l}))}return e}function tC(t){return t.map(e=>({name:e.name,length:e.length}))}function cn(t,e){const n=Math.floor(e/t.lineBases);return t.offset+n*t.lineWidth+(e-n*t.lineBases)}function eC(t,e,n){const A=Math.max(0,Math.min(t.length,Math.floor(e))),s=Math.max(A,Math.min(t.length,Math.ceil(n)));return s<=A?{from:cn(t,A),to:cn(t,A)}:{from:cn(t,A),to:cn(t,s-1)+1}}function nC(t){let e=0;for(let s=0;s<t.length;s++)t[s]>32&&e++;if(e===t.length)return t;const n=new Uint8Array(e);let A=0;for(let s=0;s<t.length;s++)t[s]>32&&(n[A++]=t[s]);return n}const ma=/\.(fa|fasta|fna|fas)$/i;function AC(t){if(/\.b?gz$/i.test(t))return`${t}.tbi`;if(/\.bam$/i.test(t))return`${t}.bai`;if(ma.test(t))return`${t}.fai`}const JA=18,sC=4,rC=/\.(biginteract|interact)(\.b?gz)?$/i;function oC(t){return t!==void 0&&t!==""&&Number.isFinite(Number(t))}function fo(t){return t==="+"||t==="-"||t==="."||t===""}function wa(t,e=""){const n=rC.test(e);let A=0,s=0;const r=t.length;for(;s<r&&A<sC;){let o=t.indexOf(`
+`,s);o<0&&(o=r);let i=o;i>s&&t.charCodeAt(i-1)===13&&i--;const a=t.slice(s,i);if(s=o+1,a===""||a.charCodeAt(0)===35||a.startsWith("track ")||a.startsWith("browser "))continue;const c=a.includes("	")?a.split("	"):a.trim().split(/\s+/);if(!iC(c,n))return!1;A++}return A>0}function iC(t,e){if(e?t.length<JA:t.length!==JA)return!1;for(const n of[1,2,9,10,14,15])if(!R(t[n]))return!1;return!R(t[4])||!oC(t[5])||!e&&!(fo(t[12])&&fo(t[17]))?!1:e||aC(t)}function aC(t){const e=t[0],n=Number(t[1]),A=Number(t[2]);if(!(A>n))return!1;let s=!1;for(const[r,o,i]of[[8,9,10],[13,14,15]])if(t[r]===e&&(s=!0,Number(t[o])<n||Number(t[i])>A))return!1;return s}function pa(t){const e=new $n;let n=0;if(wt(t,A=>{if(A.length<JA){n++;return}const s=A[9],r=A[10],o=A[14],i=A[15];if(!R(s)||!R(r)||!R(o)||!R(i)){n++;return}const a=Cn(A[11]),c=Cn(A[16]);e.add(A[8]??"",Number(s),Number(r),A[13]??"",Number(o),Number(i),{score:gC(A[5]),name:Cn(A[3])||lC(a,c),detail:cC(A,a,c)})}),e.length===0)throw new Error(`No usable rows: all ${n} lines failed the eighteen-column test an interact file is made of. UCSC writes BED5+13 — chrom, start, end, name, score, value, exp, colour, then the source and target triples and their strands.`);return e.finish()}function cC(t,e,n){const A=[],s=Cn(t[6]);s!==""&&A.push(`exp ${s}`);const r=t[4];r!==void 0&&r!==""&&r!=="0"&&A.push(`score ${r}`),(e!==""||n!=="")&&A.push(`${e||"?"} → ${n||"?"}`);const o=`${ho(t[12])}${ho(t[17])}`;return o!==".."&&A.push(`strands ${o}`),A.join(ct)}function lC(t,e){return t===""&&e===""?"":`${t||"?"}/${e||"?"}`}function Cn(t){return t===void 0||t==="."?"":t}function ho(t){return t==="+"||t==="-"?t:"."}function gC(t){return t===void 0||t===""||t==="."?Number.NaN:Number(t)}function fC(t){return/\bsourceChrom\b/.test(t)&&/\btargetChrom\b/.test(t)}function hC(t){let e=0;for(let A=0;A<t.length;A++)t.contig1[A]!==t.contig2[A]&&e++;const n=[`${t.length.toLocaleString()} interaction${t.length===1?"":"s"}`];return e>0&&n.push(`${e.toLocaleString()} between sequences`),n.join(" · ")}const ya=/^([^\s:]+):(\d+)-(\d+)(?:,(.+))?$/,uC=4,IC=/\.(longrange|longtabix)(\.(bed|txt))?(\.b?gz)?$/i;function Na(t,e=""){const n=IC.test(e);let A=0,s=0;const r=t.length;for(;s<r&&A<uC;){let o=t.indexOf(`
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+`,n);s<0&&(s=A);let r=s;r>n&&t.charCodeAt(r-1)===13&&r--;const o=t.slice(n,r);if(n=s+1,o===""||o.charCodeAt(0)===35||o.startsWith("track ")||o.startsWith("browser "))continue;const i=o.includes("	")?o.split("	"):o.trim().split(/\s+/);if(Ra(i)===null)return!1;e++}return e>0}function bC(t){if(t==="gneg")return 0;if(t.startsWith("gpos")){const e=t.slice(4);if(e==="")return 100;const n=Number(e);return Number.isFinite(n)?Math.max(0,Math.min(100,n)):100}return Number.NaN}function MC(t){const e=t.indexOf(`${OA} `);if(e<0)return"";const n=e+OA.length+1,A=t.indexOf(" ",n);return A<0?t.slice(n):t.slice(n,A)}function Ga(t){const e=new et;let n=0;if(wt(t,A=>{const s=Ra(A);if(s===null){n++;return}e.add(A[0],Number(A[1]),Number(A[2]),{name:s.name,score:bC(s.stain),detail:`${OA} ${s.stain}`})}),e.length===0&&n>0)throw new Error(`No usable rows: all ${n} lines failed the "sequence, start, end, band, stain" test a cytoBand is made of.`);return e.finish()}function DC(t){const e=[];for(let n=0;n<t.contigs.length;n++){const A=t.contigAt[n],s=t.contigAt[n+1];if(s<=A)continue;let r=0;for(let o=A;o<s;o++){if(t.start[o]!==r)return null;r=t.end[o]}e.push({name:t.contigs[n],length:r})}return e.length>0?e:null}function xa(t){let e=0,n=0;for(let r=0;r<t.length;r++)MC(t.detail[r])==="acen"&&e++,t.name[r]!==""&&n++;const A=t.contigAt.reduce((r,o,i)=>i<t.contigs.length&&t.contigAt[i+1]>t.contigAt[i]?r+1:r,0),s=[`${x.int(t.length)} band${t.length===1?"":"s"}`,`${x.int(A)} sequence${A===1?"":"s"}`];return n<t.length&&s.push(`${x.int(n)} named`),e>0&&s.push(`${x.int(e)} centromeric`),s.join(" · ")}const FC=["non-canonical","GT/AG","GT/AG","GC/AG","GC/AG","AT/AC","AT/AC"],SC="multi",RC="motif",YA="annotated",LC="overhang",GC="anchors",xC=8;function vC(t){const e=[];let n=!1,A=0;const s=t.length;for(;A<s&&e.length<xC;){let r=t.indexOf(`
+`,A);r<0&&(r=s);let o=r;o>A&&t.charCodeAt(o-1)===13&&o--;const i=t.slice(A,o);if(A=r+1,!(i===""||i.charCodeAt(0)===35)){if(i.startsWith("track ")){/junction/i.test(i)&&(n=!0);continue}i.startsWith("browser ")||e.push(i.includes("	")?i.split("	"):i.trim().split(/\s+/))}}return{rows:e,declared:n}}function va(t){if(t.length!==9)return!1;for(let s=1;s<9;s++)if(!R(t[s]))return!1;const e=Number(t[3]),n=Number(t[4]),A=Number(t[5]);return Number(t[2])>=Number(t[1])&&e>=0&&e<=2&&n>=0&&n<=6&&(A===0||A===1)}function Ua(t){if(t.length<12||!R(t[1])||!R(t[2])||t[9]!=="2")return null;const e=t[10].split(",").filter(a=>a!==""),n=t[11].split(",").filter(a=>a!=="");if(e.length!==2||n.length!==2||!e.every(R)||!n.every(R))return null;const A=Number(t[1]),s=Number(t[2]),r=Number(e[0]),o=Number(e[1]),i=Number(n[1]);return Number(n[0])!==0||A+i+o!==s||r<=0||o<=0||i<=r?null:[A+r,i-r,o]}function Ta(t){return t.length===6&&R(t[1])&&R(t[2])&&R(t[4])&&(t[5]==="+"||t[5]==="-"||t[5]===".")}function Ds(t,e=""){const{rows:n,declared:A}=vC(t);if(n.length===0)return null;if(n.every(va))return"star";const s=/junc|(^|[._-])sj([._-]|$)/i.test(e.replace(/\.b?gz$/i,"")),r=n.every(o=>/^JUNC/i.test(o[3]??""));return(s||A||r)&&n.every(o=>Ua(o)!==null)?"bed":/\.junc(\.b?gz)?$/i.test(e)&&n.every(Ta)?"junc":null}function Io(t){return t==="+"?1:t==="-"?-1:0}function UC(t){if(t===void 0||t===""||t===".")return Number.NaN;const e=Number(t);return Number.isFinite(e)?e:Number.NaN}function $a(t,e="",n){const A=Ds(t,e);if(A===null)throw new Error("This is not a junction file STAR, regtools or leafcutter wrote.");const s=new et;let r=0;if(wt(t,o=>{if(A==="star"){if(!va(o)){r++;return}const i=Number(o[3]),a=Number(o[4]),c=[`${SC} ${o[7]}`,`${RC} ${FC[a]}`,`${YA} ${o[5]==="1"?"yes":"no"}`,`${LC} ${o[8]}`].join(ct);s.add(o[0],Number(o[1])-1,Number(o[2]),{strand:i===1?1:i===2?-1:0,score:Number(o[6]),detail:c});return}if(A==="bed"){const i=Ua(o);if(i===null){r++;return}const[a,c,l]=i,g=a-Number(o[1]),f=o[3]!==void 0&&o[3]!=="."?o[3]:"";s.add(o[0],a,a+c,{strand:Io(o[5]),score:UC(o[4]),name:f,detail:`${GC} ${g}/${l}`});return}if(!Ta(o)){r++;return}s.add(o[0],Number(o[1]),Number(o[2]),{strand:Io(o[5]),score:Number(o[4]),name:o[3]!=="."?o[3]:""})}),s.length===0&&r>0)throw new Error(`No usable rows: all ${r} lines failed the junction test for this file's shape.`);return s.finish()}function Ja(t){let e=0,n=0,A=!1;for(let r=0;r<t.length;r++){const o=t.score[r];Number.isFinite(o)&&(e+=o);const i=t.detail[r];i.includes(`${YA} `)&&(A=!0,i.includes(`${YA} yes`)&&n++)}const s=[`${x.int(t.length)} junction${t.length===1?"":"s"}`,`${x.int(e)} read${e===1?"":"s"}`];return A&&s.push(`${x.int(n)} annotated`),s.join(ct)}const _A=11,Gn=9,KA=10,TC=4,$C=/\.(bedmethyl|bigmethyl|bed ?methyl)(\.b?gz)?$/i;function Oa(t,e=""){const n=$C.test(e);let A=0,s=0;const r=t.length;for(;s<r&&A<TC;){let o=t.indexOf(`
+`,s);o<0&&(o=r);let i=o;i>s&&t.charCodeAt(i-1)===13&&i--;const a=t.slice(s,i);if(s=o+1,a===""||a.charCodeAt(0)===35||a.startsWith("track ")||a.startsWith("browser "))continue;const c=a.includes("	")?a.split("	"):a.trim().split(/\s+/);if(!JC(c,n))return!1;A++}return A>0}function JC(t,e){if(t.length<_A||!R(t[1])||!R(t[2]))return!1;const n=Number(t[KA]);if(t[KA]===""||!Number.isFinite(n))return!1;if(e)return!0;if(!R(t[Gn])||Number(t[Gn])<0||n<0||n>100)return!1;const A=t[5];return A!=="+"&&A!=="-"&&A!=="."?!1:Number(t[2])-Number(t[1])===1}function Ya(t){const e=new Map;Qo(t,c=>{if(c.length<_A||!R(c[1])||!R(c[2]))return;const l=Co(c[3]);e.set(l,(e.get(l)??0)+1)});const n=[...e.entries()].map(([c,l])=>({code:c,label:Vl(c),rows:l})).sort((c,l)=>l.rows-c.rows||c.code.localeCompare(l.code));if(n.length===0)throw new Error("This looks like a bedMethyl but holds no usable rows.");const A=n[0].code,s=new Map;let r=Number.POSITIVE_INFINITY,o=Number.NEGATIVE_INFINITY,i=0,a=0;if(Qo(t,c=>{if(c.length<_A||!R(c[1])||!R(c[2])||Co(c[3])!==A)return;const l=Number(c[1]),g=Number(c[2]);if(g<=l)return;const f=Number(c[KA]);if(!Number.isFinite(f))return;const h=R(c[Gn])?Number(c[Gn]):0;if(h<=0)return;const u=c[0]??"";let I=s.get(u);I===void 0&&(I=new Qs(u),s.set(u,I)),I.push(l,g,f),i++,a+=h,f<r&&(r=f),f>o&&(o=f)}),i===0)throw new Error("This looks like a bedMethyl but every row rests on zero reads, so there is no measurement to draw.");return{signal:Bs(s,i,r,o),codes:n,drawn:A,meanCoverage:a/i}}function Co(t){return t===void 0||t===""||t==="."?"?":t}function Qo(t,e){for(const n of t.split(`
+`)){let A=n;A.endsWith("\r")&&(A=A.slice(0,-1)),!(A===""||A.charCodeAt(0)===35)&&(A.startsWith("track ")||A.startsWith("browser ")||e(A.includes("	")?A.split("	"):A.trim().split(/\s+/)))}}function OC(t){return/\b(percentMod|percentMeth|fractionModified)\b/.test(t)&&/\b(validCov|coverage|Nvalid_cov)\b/.test(t)}function YC(t){const e=t.codes.find(s=>s.code===t.drawn),n=[`${t.signal.length.toLocaleString()} ${e?.label??t.drawn} calls`,`${t.meanCoverage.toFixed(1)}× mean depth`],A=t.codes.filter(s=>s.code!==t.drawn);return A.length>0&&n.push(`not drawn: ${A.map(s=>`${s.label} (${s.rows.toLocaleString()})`).join(", ")}`),n.join(" · ")}const xn=440477507,vn=".2bit",_a=16,_C=new Uint8Array([84,67,65,71]),KC=78;function Ka(t){if(t.length<4)return!1;const e=new DataView(t.buffer,t.byteOffset,4);return e.getUint32(0,!0)===xn||e.getUint32(0,!1)===xn}function qC(t){if(t.length<_a)throw new Error("This file starts like a .2bit and is too short to hold one.");const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=e.getUint32(0,!0)===xn;if(!n&&e.getUint32(0,!1)!==xn)throw new Error("This is not a .2bit: its first four bytes are not the format’s signature.");const A=e.getUint32(4,n);if(A!==0)throw new Error(`This is a .2bit of version ${A}. This viewer reads version 0 — the ordinary one, with 32-bit offsets. Version 1 is the “long” variant for files past 4 GB, whose offsets and sizes are 64-bit, and reading one as though it were version 0 would return wrong residues rather than fail. Convert it with \`twoBitToFa\` and \`faToTwoBit\`.`);const s=e.getUint32(8,n);if(s===0)throw new Error("This .2bit declares no sequences.");return{littleEndian:n,version:A,count:s}}function Bo(t,e,n=_a){const A=new DataView(t.buffer,t.byteOffset,t.byteLength),s=[];let r=n;const o=new TextDecoder;for(;s.length<e.count&&!(r+1>t.length);){const i=t[r];if(r+1+i+4>t.length)break;const a=o.decode(t.subarray(r+1,r+1+i)),c=A.getUint32(r+1+i,e.littleEndian);s.push({name:a,offset:c}),r+=1+i+4}return{entries:s,complete:s.length===e.count,consumed:r}}function Eo(t,e,n,A={}){if(e+8>t.length)return 8;const s=new DataView(t.buffer,t.byteOffset,t.byteLength),r=qa(s,e,n,A),o=e+8+r*8;return o+4>t.length?o+4-e:null}function qa(t,e,n,A){return nt(t.getUint32(e+4,n),{format:vn,field:`N-block count${A.name===void 0?"":` of ${A.name}`}`,ceiling:t.getUint32(e,n),...A.fileLeft===void 0?{}:{available:A.fileLeft-8-4},bytesPerItem:8})}function HC(t,e,n,A,s=0,r){const o=new DataView(e.buffer,e.byteOffset,e.byteLength),i=o.getUint32(n,A),a=qa(o,n,A,{name:t,fileLeft:e.length-n}),c=new Int32Array(a),l=new Int32Array(a),g=n+8,f=g+a*4;for(let d=0;d<a;d++){const C=o.getUint32(g+d*4,A);c[d]=C,l[d]=C+o.getUint32(f+d*4,A)}const h=f+a*4,u=nt(o.getUint32(h,A),{format:vn,field:`mask-block count of ${t}`,ceiling:i,...r===void 0?{}:{available:r-(s+h+4)-4},bytesPerItem:8}),I=s+h+4+u*8+4;return r!==void 0&&rs(I,Math.ceil(i/4),{format:vn,field:`packed bases of ${t}`,size:r}),{name:t,length:i,nStarts:c,nEnds:l,dnaAt:I}}const WC=8192;function PC(t,e,n){const A=Math.max(0,Math.min(e,t.length)),s=Math.max(A,Math.min(n,t.length)),r=Math.floor(A/4),o=Math.ceil(s/4);return{from:t.dnaAt+r,to:t.dnaAt+o,firstBase:r*4}}function zC(t,e,n,A,s){const r=Math.max(0,Math.min(A,n.length)),o=Math.max(r,Math.min(s,n.length)),i=new Uint8Array(o-r);for(let a=r;a<o;a++){const c=a-e,l=t[c>>2];if(l===void 0)break;const g=6-((c&3)<<1);i[a-r]=_C[l>>g&3]}for(let a=0;a<n.nStarts.length;a++){const c=n.nStarts[a];if(c>=o)break;const l=n.nEnds[a];l<=r||i.fill(KC,Math.max(r,c)-r,Math.min(o,l)-r)}return i}function XC(t){return t.map(e=>({name:e.name,length:e.length}))}const mo=65536,wo=1e5;async function VC(t,e){let n=await t(mo,0);const A=qC(n);if(A.count>wo)throw new Error(`This .2bit declares ${A.count.toLocaleString()} sequences, which is past the ${wo.toLocaleString()} this viewer will open one record at a time. A file that says this is far more likely to be truncated than to be an assembly.`);let s=Bo(n,A);for(;!s.complete;){const a=await t(mo,n.length);if(a.length===0)throw new Error(`This .2bit ends part-way through its index: it declares ${A.count.toLocaleString()} sequences and names ${s.entries.length.toLocaleString()}. The file is truncated.`);const c=new Uint8Array(n.length+a.length);c.set(n),c.set(a,n.length),n=c,s=Bo(n,A)}const r=new Map,o=[];let i=0;for(const a of s.entries){e!==void 0&&rs(a.offset,8,{format:vn,field:`index entry for ${a.name}`,size:e});const c={name:a.name,...e===void 0?{}:{fileLeft:e-a.offset}};let l=await t(WC,a.offset),g=Eo(l,0,A.littleEndian,c);for(;g!==null;){const h=await t(g,a.offset);if(h.length<=l.length)throw new Error(`This .2bit ends part-way through the record for ${a.name}.`);l=h,g=Eo(l,0,A.littleEndian,c)}const f=HC(a.name,l,0,A.littleEndian,a.offset,e);r.set(f.name,f),o.push(f),i+=f.length}return{ordered:o,records:r,total:i}}const ZC=2291137574,jC=2273964779,po=[137,72,68,70,13,10,26,10];function tQ(t){return t.length<po.length?!1:po.every((e,n)=>t[n]===e)}function Ha(t){if(t.length<4)return null;const e=new DataView(t.buffer,t.byteOffset,4);for(const n of[!0,!1]){const A=e.getUint32(0,n);if(A===ZC)return"bigwig";if(A===jC)return"bigbed"}return null}function ft(t,e){const n=pe(cl(t),e);for(let A=0;A<n.names.length;A++)t[A]=n.names[A];return n}function Z(t,e,n){const A=pl(t,za(e)),s=eQ(t,e),r=n?.contested??[];return{...A,...s===null?{}:{genomes:s},...r.length===0?{}:{contested:r.slice(0,4).map(o=>`${o.asked} → ${o.name}`)}}}function eQ(t,e){const n=new Set;for(const r of e)r.genome!==void 0&&r.genome!==""&&n.add(r.genome);if(n.size===0)return null;const A=new Set(t),s=new Set;for(const r of e)r.genome===void 0||r.genome===""||A.has(r.name)&&s.add(r.genome);return{matched:s.size,total:n.size,named:[...s].slice(0,4)}}function qn(t,e){const n=t.bases.get(e);if(n!==void 0)return n;const A=Kt(t.contigs,e);return A<0?void 0:t.bases.get(t.contigs[A].name)}function Fs(t,e){const n=t.records.get(e);if(n!==void 0)return n;const A=Kt(t.contigs,e);return A<0?void 0:t.records.get(t.contigs[A].name)}async function Wa(t,e,n,A,s){const r=Fs(t,e);if(r===void 0)return;const o=Math.max(0,Math.floor(n)),i=Math.min(r.length,Math.ceil(A));if(!(i>o))return new Uint8Array(0);const a=t.held.get(r.name);if(a!==void 0&&a.start<=o&&a.start+a.bases.length>=i)return a.bases.subarray(o-a.start,i-a.start);const c=await Pa(t,r,o,i,s);return t.held.set(r.name,{start:o,bases:c}),c}async function Pa(t,e,n,A,s){const r=s===void 0?{}:{onProgress:s};if(_t(t)){const i=e,a=PC(i,n,A),c=await t.handle.read(a.to-a.from,a.from,r);return zC(c,a.firstBase,i,n,A)}const o=eC(e,n,A);return nC(await t.handle.read(o.to-o.from,o.from,r))}function za(t){return t.map(e=>e.name)}const Ss=new Map,Hn=new Map;function Rs(t){return t.indexed===!0}function _t(t){return t.twobit===!0}function we(t){return Rs(t)||_t(t)}const re=new Map,qA=new Map,Wn=new Map,Un=new Map;function nQ(t,e){return`${tt(t)}|${tt(e)}`}const yo=8<<20,Ls=3e8,HA=64e6,No=4e6;let Dt=null,oe=null;function tt(t){return t.kind==="local"?`${t.name}|${t.file.size}`:t.url}self.onmessage=t=>{sQ(t.data)};const AQ=Mh();setInterval(()=>{const t={type:"busy",fraction:AQ.busy()};self.postMessage(t)},bh);const Pn=new Set,WA=new Set;let PA=0;function zA(t){return Pn.has(t)}async function Gs(t){return await Es(),!Pn.has(t)}function ze(){const t=new Error("cancelled");return t.name="AbortError",t}async function sQ(t){WA.add(t.id);try{const e=await rQ(t);if(zA(t.id))throw ze();const n={type:"result",id:t.id,payload:e};self.postMessage(n,ph(e))}catch(e){const n={type:"error",id:t.id,message:e instanceof Error?e.message:String(e),...e instanceof Error&&e.name==="AbortError"?{cancelled:!0}:{}};self.postMessage(n)}finally{WA.delete(t.id),Pn.delete(t.id),t.id>PA&&(PA=t.id)}}function Qn(t){return(e,n)=>{const A={type:"progress",id:t,done:e,total:n??0};self.postMessage(A)}}async function rQ(t){switch(t.kind){case"load":return hQ(t.entry,t.source,t.mapContigs,Qn(t.id));case"sample":return Ac(t.entry,t.regions,t.basesPerPixel,t.reads,t.id,t.exact===!0);case"register":return qA.set(t.entry,t.vector),null;case"run":return oQ(t);case"bases":return NQ(t.entry,t.regions,Qn(t.id));case"assembly":return iQ(t.source,Qn(t.id));case"reads":return YQ(t.entry,t.regions,t.maxRows,t.basesPerPixel,t.reads,t.id);case"cancel":return(WA.has(t.target)||t.target>PA)&&Pn.add(t.target),null;case"drop":{Ss.delete(t.entry);const e=re.get(t.entry);e!==void 0&&oe?.store===e&&(oe=null),re.delete(t.entry),qA.delete(t.entry),Hn.delete(t.entry),Wn.delete(t.entry);for(const[n,A]of Un)if(A.holders.delete(t.entry)){A.holders.size===0&&Un.delete(n);break}return null}}}async function oQ(t){const e=Xd[t.task];if(e===void 0)throw new Error(`no track analysis runner is registered for the task ${t.task}`);const n=[],A=performance.now(),s={params:t.params,framing:t.framing,inputs:t.inputs,cancelled:()=>zA(t.id),throwIfCancelled:()=>{if(zA(t.id))throw ze()},progress:(o,i,a)=>{const c={type:"progress",id:t.id,done:o,total:i,...a===void 0?{}:{note:a}};self.postMessage(c)},note:o=>{n.push(o)},sample:(o,i,a)=>Ac(o,i,a,void 0,t.id),lengthOf:o=>t.inputs.contigLengths?.[o],residues:o=>{const i=re.get(o);if(i!==void 0)return we(i)?{contigs:i.contigs,bases:()=>{},read:async(a,c,l)=>{const g=Fs(i,a);if(g===void 0)return;const f=Math.max(0,Math.floor(c)),h=Math.min(g.length,Math.ceil(l));return h>f?Pa(i,g,f,h):new Uint8Array(0)},refusal:_t(i)?`This .2bit is read by range rather than held, so its sequences are not here whole to read. A FASTA under ${x.int(HA/1e6)} MB is held whole (\`twoBitToFa\`).`:`This FASTA is read by range from its index rather than held, so its sequences are not here whole to read. A FASTA under ${x.int(HA/1e6)} MB is held whole.`}:{contigs:i.contigs,bases:a=>qn(i,a)}}};return{outputs:await e(s),provenance:{task:t.task,taskVersion:0,params:t.params,framing:t.framing,app:[Vd,Zd].filter(o=>o!=="").join(" "),createdAt:new Date().toISOString()},notes:n,ms:performance.now()-A}}async function iQ(t,e){const n=Gt(t),A=await n.read(64,0);if(tQ(A))return{format:"hdf5",contigs:[],origin:"features",exact:!0};const s=Ha(A);if(s!==null){const h=await(s==="bigwig"?new Jo({filehandle:Gt(t)}):new Yo({filehandle:Gt(t)})).getHeader();return{format:s,contigs:xs(h),origin:s,exact:!0}}if(We(A)){const f=await ke(n,t),h=await sc(n,f??Number.MAX_SAFE_INTEGER);if(h!==null)return{format:"bam",contigs:h.refs.map(u=>({name:u.name,length:u.length})),origin:"bam",exact:!0}}if(kn(A))return{format:"fasta",contigs:(await tc(t,n,e)).contigs,origin:"fasta",exact:!0};if(Ka(A))return{format:"twobit",contigs:(await ec(t,n,e)).contigs,origin:"twobit",exact:!0};const r=await n.readFile({onProgress:e}),o=await gs(r);if(kn(o))return{format:"fasta",contigs:Us(t,o).contigs,origin:"fasta",exact:!0};const i=new TextDecoder().decode(o);if(i.trim()==="")throw new Error("This file is empty.");if(Fh(i,t.name))return Dt={key:tt(t),format:"sizes",features:null},{format:"sizes",contigs:Dh(i),origin:"sizes",exact:!0};if(Ai(i)){const f=ag(i);if(f.length>0)return{format:"vcf",contigs:f,origin:"vcf",exact:!0};const h=oi(i),u=new Map;for(let I=0;I<h.length;I++)lt(u,h.contigs[h.contig[I]],h.end[I]);return{format:"vcf",contigs:It(u),origin:"features",exact:!1}}if(ds(A)){const f=await ja(n),h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"structure",contigs:It(h),origin:"features",exact:!1}}if(yA(i,t.name)||pA(i,t.name)||Bi(i,t.name)){const f=yA(i,t.name)?ki(i,t.name):pA(i,t.name)?wi(i,t.name):pi(i,t.name),h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"structure",contigs:It(h),origin:"features",exact:!1}}if(hi(i,t.name)){const f=di(i,t.name),h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"barchart",contigs:It(h),origin:"features",exact:!1}}if(La(i)){const f=Ga(i);Dt={key:tt(t),format:"cytoband",features:f};const h=DC(f);if(h!==null)return{format:"cytoband",contigs:h,origin:"cytoband",exact:!0};const u=new Map;for(let I=0;I<f.length;I++)lt(u,f.contigs[f.contig[I]],f.end[I]);return{format:"cytoband",contigs:It(u),origin:"features",exact:!1}}if(Ds(i,t.name)!==null){const f=$a(i,t.name);Dt={key:tt(t),format:"junctions",features:f};const h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"junctions",contigs:It(h),origin:"features",exact:!1}}if(wa(i,t.name)){const f=pa(i);return{format:"interact",contigs:uA(f),origin:"features",exact:!1}}if(Na(i,t.name)){const f=ka(i);return{format:"longrange",contigs:uA(f),origin:"features",exact:!1}}if(Da(i,t.name)){const f=Fa(i);Dt={key:tt(t),format:"genepred",features:f};const h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"genepred",contigs:It(h),origin:"features",exact:!1}}if(Oa(i,t.name)){const{signal:f}=Ya(i),h=new Map;for(const u of f.contigs){let I=0;for(const d of u.ends)d>I&&(I=d);lt(h,u.name,I)}return{format:"bedmethyl",contigs:It(h),origin:"features",exact:!1}}const a=Gi(i);if(a!==null){const f=a==="wig"?vi(i):xi(i);Dt={key:tt(t),format:a,features:null};const h=new Map;for(const u of f.contigs){let I=0;for(const d of u.ends)d>I&&(I=d);lt(h,u.name,I)}return{format:a,contigs:It(h),origin:"features",exact:!1}}const c=ii(i,t.name);if(c==="bedpe"){const f=fi(i);return Dt={key:tt(t),format:c,features:null},{format:c,contigs:uA(f),origin:"features",exact:!1}}const l=c==="gtf"?li(i):hs(i,t.name);Dt={key:tt(t),format:c,features:l};const g=new Map;for(let 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fetch(o,Oi(i,{url:a,...n===void 0?{}:{headers:n},...e===void 0?{}:{credential:e}}))}});for(Zt.set(A,r);Zt.size>aQ;){const o=Zt.keys().next().value;Zt.delete(o)}return r}async function cQ(t,e,n,A){const s=vs(t);if(s===null||!We(n))return null;try{const r=await Yt(await Gt(s).readFile()),o=El(r),i=await ke(e,t);if(i===null)return null;const a=ml(o,wl(o,za(A)),i);if(a.length===0||a.reduce((f,h)=>f+(h.to-h.from),0)>i*.8)return null;const l=[];for(const f of a){const h=await e.read(f.to-f.from,f.from),u=new TextDecoder().decode(await Yt(h,f.lastBlock-f.from));l.push(lQ(u,f.from===0,fQ(h,f,i)))}const g=l.join("");return g===""?null:g}catch{return null}}function lQ(t,e,n){let A=t;if(!e){const s=A.indexOf(`
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Number.isFinite(o)&&o>0?o:null}catch{return null}}async function aQ(t,e,n,A){const s=xt(e),r=await s.read(64,0),o=Oa(r);if(o==="bigwig")return wQ(t,e,n);if(o==="bigbed")return mQ(t,e,n);if(We(r)){const I=await ke(s,e),d=await tc(s,I??Number.MAX_SAFE_INTEGER);if(d!==null){if(I===null)throw new Error(`${e.name} cannot be measured — its host states neither Content-Range nor Content-Length to a page — and a BAM is read by byte range.`);return kQ(t,e,s,n,d,I,A)}}if(kn(r))return IA(t,await Xa(e,s,A),n);if($a(r))return IA(t,await Va(e,s,A),n);if(Is(r))return uQ(s,n);const i=Mt;if(i!==null&&i.key===tt(e)&&i.features!==null)return Mt=null,zA(i.format,i.features,n);const a=await sQ(e,s,r,n),c=a===null?await ls(await s.readFile({onProgress:A})):null;if(c!==null&&kn(c))return IA(t,Us(e,c),n);const l=a??new TextDecoder().decode(c);if(l.trim()==="")throw new Error("This file is empty.");if(ti(l))return cQ(l,n);if(pA(l,e.name))return uA(l,e.name,n,pi);if(wA(l,e.name))return uA(l,e.name,n);if(di(l,e.name))return uA(l,e.name,n,Ei);if(li(l,e.name))return Pa(l,e.name,n);if(Ma(l))return fQ(l,n);if(Ds(l,e.name)!==null)return hQ(l,e.name,n);if(Qa(l,e.name))return Ha(l,n);if(ma(l,e.name))return lQ(l,n);if(Na(l,e.name))return gQ(l,n);if(va(l,e.name))return Wa(t,l,n);const f=Si(l);if(f!==null)return pQ(t,f,l,n);const h=si(l,e.name);if(h==="bedpe"){const I=ci(l),d=ft(I.contigs,n);return{format:h,contigs:I.contigs,overlap:Z(I.contigs,n,d),summary:`${G.int(I.length)} pair${I.length===1?"":"s"}`,payload:{kind:"pairs",data:I}}}const u=h==="gtf"?ii(l):fs(l,e.name);return zA(h,u,n)}function cQ(t,e){const n=Ai(t),A=ft(n.contigs,e),s=Ag(t);return{format:"vcf",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:`${G.int(n.length)} variant${n.length===1?"":"s"}`+(s===0?"":` · ${G.int(s)} sample${s===1?"":"s"} not drawn`),payload:{kind:"features",data:n}}}function Ha(t,e){const n=Ba(t),A=ft(n.contigs,e);return{format:"interact",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:aC(n),payload:{kind:"pairs",data:n}}}function lQ(t,e){const n=wa(t),A=ft(n.contigs,e);return{format:"longrange",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:gC(n),payload:{kind:"pairs",data:n}}}function gQ(t,e){const n=ka(t),A=ft(n.contigs,e);return{format:"genepred",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:bs(n),payload:{kind:"features",data:n}}}function Wa(t,e,n){const A=Ta(e),s=A.signal,r=pe(s.contigs.map(a=>({name:a.name})),n);s.contigs.forEach((a,c)=>{a.name=r.names[c]});const o=new xi(s);Hn.set(t,o);const i=o.contigNames;return{format:"bedmethyl",contigs:i,overlap:Z(i,n,r),summary:vC(A),fileExtent:{min:0,max:100}}}function Pa(t,e,n){const A=hi(t,e),s=ft(A.contigs,n);return{format:"barchart",contigs:A.contigs,overlap:Z(A.contigs,n,s),summary:Tg(A),payload:{kind:"features",data:A}}}function fQ(t,e){const n=Fa(t),A=ft(n.contigs,e);return{format:"cytoband",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:Sa(n),payload:{kind:"features",data:n}}}function hQ(t,e,n){const A=Ga(t,e),s=ft(A.contigs,n);return{format:"junctions",contigs:A.contigs,overlap:Z(A.contigs,n,s),summary:Ua(A),payload:{kind:"features",data:A}}}function uA(t,e,n,A=Bi){const s=A(t,e),r=ft(s.contigs,n);return{format:"structure",contigs:s.contigs,overlap:Z(s.contigs,n,r),summary:wi(s),payload:{kind:"features",data:s}}}async function za(t){const e=(o,i)=>t.read(o,i),n=await ke(t),A=await ef(e,n??void 0),s=Math.min(...A.resolutions),r=await nf(e,A,s);return Object.assign(r,{header:A})}async function uQ(t,e){const n=await za(t),A=ft(n.contigs,e),s=n.header.resolutions.filter(o=>o!==n.model?.width),r=[wi(n),Af(n.header),...s.length===0?[]:[`also at ${s.join(", ")} bp`]].join(ct);return{format:"structure",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:r,payload:{kind:"features",data:n}}}function zA(t,e,n){const A=e.exonStart.length,s=ft(e.contigs,n);return{format:t,contigs:e.contigs,overlap:Z(e.contigs,n,s),summary:t==="gtf"?`${G.int(e.length)} transcripts · ${G.int(A)} exons`:t==="genepred"?bs(e):t==="cytoband"?Sa(e):t==="junctions"?Ua(e):`${G.int(e.length)} feature${e.length===1?"":"s"}`,payload:{kind:"features",data:e}}}async function Xa(t,e,n){const A=oe;if(A!==null&&A.key===tt(t))return A.store;const s=t.kind==="local"?t.file.size:await ke(e,t),r=s!==null&&s>0;if(r&&s<=qA)return yo(t,e,n);const o=await IQ(t,e);if(o!==null)return oe={key:tt(t),store:o},o;if(r&&s>Rs)throw Za(s,t);return yo(t,e,n)}async function yo(t,e,n){return Us(t,await ls(await e.readFile({onProgress:n})))}async function IQ(t,e){const n=t.index!==void 0?t:t.kind==="remote"&&Ca.test(t.url)?{...t,index:Zd(t.url)}:null,A=n===null?null:Gs(n);if(A===null)return null;try{const s=Pd(new TextDecoder().decode(await xt(A).readFile()));return s.length===0?null:{indexed:!0,contigs:zd(s),records:new Map(s.map(r=>[r.name,r])),handle:e,total:s.reduce((r,o)=>r+o.length,0),held:new Map}}catch{return null}}async function Va(t,e,n){const A=oe;if(A!==null&&A.key===tt(t)&&_t(A.store))return A.store;const s=await ke(e),r=await HC((i,a)=>e.read(i,a,{onProgress:n}),s??void 0),o={twobit:!0,contigs:qC(r.ordered),records:r.records,handle:e,total:r.total,held:new Map};return oe={key:tt(t),store:o},o}function Us(t,e){if(e.length>Rs)throw Za(e.length,t);const n=Uf(e);if(n.contigs.length===0)throw new Error("This looks like a FASTA but holds no sequences.");return oe={key:tt(t),store:n},n}function Za(t,e){const n=e.name.replace(/[#?].*$/,"")||"genome.fa";return new Error(`This FASTA is ${G.int(Math.round(t/1e6))} MB and has no index. It would be read whole and held whole — which is what makes panning free — so anything over ${G.int(Rs/1e6)} MB is refused rather than allowed to take the tab with it. Index it (\`samtools faidx ${n}\`) and ${e.kind==="local"?"drop the .fai with it":"publish the .fai beside it, or name it with #index=<url>"}: an indexed FASTA opens at once and is read by range.`)}function IA(t,e,n){const A=CQ(e,n);re.set(t,e);const s=e.contigs.map(r=>r.name);return{format:_t(e)?"twobit":"fasta",contigs:s,overlap:Z(s,n,A),summary:`${vs(s.length)} · ${G.bp(e.total)}`+(_t(e)?" · read by range, two bits a base":Ss(e)?" · read by range from its index":""),...we(e)?{byRange:{bases:e.total,bytesPerBase:dQ(e)}}:{}}}function dQ(t){if(_t(t))return .25;let e=0,n=0;for(const A of t.records.values())e+=A.length*A.lineWidth/A.lineBases,n+=A.length;return n>0?e/n:1}function CQ(t,e){const n=pe(t.contigs,e);if(n.renamed===0)return n;if(_t(t)||Ss(t))return t.records=No(t.records,t.contigs,n.names),t.held.clear(),n;const A=new Map;return t.contigs.forEach((s,r)=>{const o=t.bases.get(s.name);s.name=n.names[r],o!==void 0&&A.set(s.name,o)}),t.bases=A,n}function No(t,e,n){const A=new Map;return e.forEach((s,r)=>{const o=t.get(s.name);s.name=n[r],o!==void 0&&A.set(s.name,{...o,name:s.name})}),A}async function QQ(t,e,n,A){const s=[];let r=Number.POSITIVE_INFINITY,o=Number.NEGATIVE_INFINITY;if(we(t)&&e.reduce((a,c)=>a+Math.max(0,c.end-c.start),0)>po)return{basesPerPixel:n,regions:[],extent:null,note:`GC under ${G.int(po/1e6)} Mb, letters at base resolution — zoom in`};for(const i of e){if(!(i.end>i.start))continue;let a;if(we(t)){const c=Math.max(0,Math.floor(i.start)),l=await _a(t,i.contig,c,i.end,A);if(l===void 0||l.length===0)continue;a=Qr(l,0,l.length,n);for(let g=0;g<a.starts.length;g++)a.starts[g]+=c,a.ends[g]+=c}else{const c=qn(t,i.contig);if(c===void 0)continue;a=Qr(c,i.start,i.end,n)}if(a.values.length!==0){for(const c of a.values)Number.isFinite(c)&&(c<r&&(r=c),c>o&&(o=c));s.push({contig:i.contig,start:i.start,end:i.end,starts:a.starts,ends:a.ends,values:a.values,min:null,max:null,variant:null,summary:!0})}}return{basesPerPixel:n,regions:s,extent:r<=o?{min:r,max:o}:null}}const BQ=4e5;async function EQ(t,e,n){const A=re.get(t);if(A===void 0)throw new Error("This sequence is no longer open. Drop the file again.");const s=[];let r=BQ;for(const o of e){const i=Math.max(0,Math.floor(o.start));if(we(A)){const l=await _a(A,o.contig,i,Math.min(Math.ceil(o.end),i+r),n);if(l===void 0||l.length===0)continue;if(r-=l.length,s.push({contig:o.contig,start:i,end:i+l.length,bases:l.slice()}),r<=0)break;continue}const a=qn(A,o.contig);if(a===void 0)continue;const c=Math.min(a.length,Math.ceil(o.end),i+r);if(c>i&&(r-=c-i,s.push({contig:o.contig,start:i,end:c,bases:a.slice(i,c)}),r<=0))break}return{regions:s}}const XA=1e6;async function mQ(t,e,n){const A=new $o({filehandle:xt(e)}),s=await A.getHeader(),r=xs(s),o=[];let i=!1;for(const f of r){if(o.length>=XA){i=!0;break}const h=await A.getFeatures(f.name,0,f.length);for(const u of h){if(o.length>=XA){i=!0;break}const I=typeof u.rest=="string"&&u.rest!==""?`	${u.rest}`:"";o.push(`${f.name}	${u.start}	${u.end}${I}`)}}const a=o.join(`
-`),c=s.autoSql??"";if(vg(c)){const f=Pa(a,e.name,n);return i?{...f,summary:Le(f.summary)}:f}if(iC(c)){const f=Ha(a,n);return i?{...f,summary:Le(f.summary)}:f}if(UC(c)){const f=Wa(t,a,n);return i?{...f,summary:Le(f.summary)}:f}const l=fs(a,e.name);if(EC(c)){const f=ft(l.contigs,n),h={format:"genepred",contigs:l.contigs,overlap:Z(l.contigs,n,f),summary:bs(l),payload:{kind:"features",data:l}};return i?{...h,summary:Le(h.summary)}:h}const g=zA("bigbed",l,n);return{...g,summary:i?Le(g.summary):g.summary}}function Le(t){return`${t} · cut off at ${G.int(XA)}`}async function wQ(t,e,n){const A=new To({filehandle:xt(e)}),s=await A.getHeader(),r=pe(xs(s),n),o=r.names;Fs.set(t,{bigwig:A,refOf:r.sourceOf,refNames:Object.keys(s.refsByName)});const i=s.totalSummary,a=i!==void 0&&Number.isFinite(i.scoreMin)&&Number.isFinite(i.scoreMax)&&i.scoreMax>i.scoreMin;return{format:"bigwig",contigs:o,overlap:Z(o,n,r),summary:vs(o.length)+(a?` · ${ie(i.scoreMin)}–${ie(i.scoreMax)}`:""),...a?{fileExtent:{min:i.scoreMin,max:i.scoreMax}}:{}}}function pQ(t,e,n,A){const s=e==="wig"?Li(n):Ri(n);if(s.length===0)throw new Error(`This looks like a ${e==="wig"?"wig":"bedGraph"} but holds no usable intervals.`);const r=pe(s.contigs.map(g=>({name:g.name})),A);s.contigs.forEach((g,f)=>{g.name=r.names[f]});const o=new xi(s);Hn.set(t,o);const i=o.contigNames,{min:a,max:c}=o.extent,l=Number.isFinite(a)&&Number.isFinite(c)&&c>a;return{format:e,contigs:i,overlap:Z(i,A,r),summary:`${G.int(o.length)} intervals · ${vs(i.length)}`+(l?` · ${ie(a)}–${ie(c)}`:""),...l?{fileExtent:{min:a,max:c}}:{}}}function yQ(t,e,n){const A=[];let s=Number.POSITIVE_INFINITY,r=Number.NEGATIVE_INFINITY;for(const o of e){if(!t.has(o.contig)||o.end<=o.start)continue;const i=t.samples(o.contig,o.start,o.end,n);if(i!==null){for(const a of i.values)Number.isFinite(a)&&(a<s&&(s=a),a>r&&(r=a));A.push({contig:o.contig,start:o.start,end:o.end,variant:null,...i})}}return{basesPerPixel:n,regions:A,extent:s<=r?{min:s,max:r}:null}}async function ja(t,e,n,A,s,r=!1){const o=Wn.get(t);if(o!==void 0)return RQ(s,o,e,n,A);const i=re.get(t);if(i!==void 0)return QQ(i,e,n,Qn(s));const a=Hn.get(t);if(a!==void 0)return yQ(a,e,n);const c=KA.get(t);if(c!==void 0)return Sh(c,e,n,r);const l=Fs.get(t);if(l===void 0)throw new Error("This track is no longer open. 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Reads are drawn by region, which needs the file sorted and indexed: run \`samtools sort -o sorted.bam ${t}\` and \`samtools index sorted.bam\`. The alignment file a Hi-C pipeline writes is in read-pair order for its pairs step and is not made for browsing; its .pairs or its contact map is the file to open.`}const DQ=4e6;function MQ(t,e){if(t.search===null)return null;const n=e.reduce((A,s)=>A+(s.end-s.start),0);return e.length>1||n>DQ?`${FQ(n)} without an index — zoom in`:null}function FQ(t){return t>=1e6?`${ie(t/1e6)} Mb`:`${ie(t/1e3)} kb`}async function ec(t,e,n,A,s){const r=Math.max(0,Math.floor(n.start)),o=Math.ceil(n.end);return t.index!==null?pf(t.index,e,r,o,t.size):t.search===null?[]:t.search.spansFor(e,r,o,async()=>{if(!await Ls(A))throw ze()},s)}function nc(t){return t===void 0?Mi:{exclude:Xo|(t.hideDuplicates?At.DUPLICATE:0),minMapq:t.minMapq}}function SQ(t){const e=nc(t);return t.splits?{...e,exclude:e.exclude&-2049}:e}async function RQ(t,e,n,A,s){const r=I=>{const d=e.refIdOf.get(I);if(d!==void 0)return d;const C=Kt(e.refNames,I);if(!(C<0))return e.refIdOf.set(I,C),C},o=n.filter(I=>r(I.contig)!==void 0&&I.end>I.start);if(o.length===0)return{basesPerPixel:A,regions:[],extent:null};const i=MQ(e,o);if(i!==null)return{basesPerPixel:A,regions:[],extent:null,note:i};const a=[];for(const I of o){const d=r(I.contig);a.push({region:I,refId:d,spans:await ec(e,d,I,t,wo)})}const c=a.reduce((I,d)=>I+bi(d.spans),0);if(c>wo)return{basesPerPixel:A,regions:[],extent:null,note:`${G.bytes(c)} of reads — zoom in`};const l=[];let g=Number.POSITIVE_INFINITY,f=Number.NEGATIVE_INFINITY;const h=s?.modFraction===!0,u=[];for(const I of a){const d=I.region.end-I.region.start,C=Math.max(1,Math.min(4096,Math.round(d/Math.max(1,A)))),E=new Float64Array(C),B=new Map;u.push(B);const Q=A<=JQ?Ac(I.region):void 0,m=Q===void 0?null:new Float64Array(C),p=new Map;for(const D of I.spans){if(!await Ls(t))throw ze();const F=await e.handle.read(D.to-D.from,D.from),R=await Ot(F,D.lastBlock-D.from),v=Jf(R,D.dataFrom,I.refId,Math.floor(I.region.start),Math.ceil(I.region.end),C,nc(s),Q,p,h?{tally:B,threshold:s.modThreshold}:void 0);for(let x=0;x<C;x++)E[x]+=v.depth[x];if(m!==null&&v.variant!==null)for(let x=0;x<C;x++)m[x]+=v.variant[x]}const w=new Int32Array(C),y=new Int32Array(C),N=new Float32Array(C),k=m===null?null:new Float32Array(C),b=d/C;for(let D=0;D<C;D++)w[D]=Math.round(I.region.start+D*b),y[D]=Math.round(I.region.start+(D+1)*b),N[D]=E[D],k!==null&&m!==null&&(k[D]=m[D]),E[D]<g&&(g=E[D]),E[D]>f&&(f=E[D]);l.push({contig:I.region.contig,start:I.region.start,end:I.region.end,starts:w,ends:y,values:N,variant:k,junctions:xQ(p),min:null,max:null,summary:!1})}return h?LQ(A,l,u,s.modCode):{basesPerPixel:A,regions:l,extent:g<=f&&f>0?{min:0,max:f}:null}}function LQ(t,e,n,A){const s=new Map;for(const c of n)for(const[l,g]of c){const f=s.get(l)??[0,0];f[0]+=g.modified.reduce((h,u)=>h+u,0),f[1]+=g.calls.reduce((h,u)=>h+u,0),s.set(l,f)}const r=[...s.entries()].sort((c,l)=>l[1][0]-c[1][0]||l[1][1]-c[1][1]).map(([c])=>c),o=A!==""?A:r[0]??"";let i=!1;const a=e.map((c,l)=>{const g=n[l].get(o),f=new Float32Array(c.values.length).fill(Number.NaN);if(g!==void 0)for(let h=0;h<f.length;h++)g.calls[h]<=0||(f[h]=100*g.modified[h]/g.calls[h],i=!0);return{...c,values:f,variant:null,junctions:void 0}});return{basesPerPixel:t,regions:a,extent:i?{min:0,max:100}:null,mods:{code:o,codes:r},...r.length===0?{note:"no MM/ML modification calls here"}:{}}}function xQ(t){const e=[];for(const[s,r]of t){const[o,i,a]=s.split(":").map(Number);e.push([o,i,a,r])}e.sort((s,r)=>s[0]-r[0]||s[1]-r[1]||s[2]-r[2]);const n=e.length,A={starts:new Int32Array(n),ends:new Int32Array(n),counts:new Float32Array(n),strands:new Int8Array(n)};return e.forEach(([s,r,o,i],a)=>{A.starts[a]=s,A.ends[a]=r,A.strands[a]=o,A.counts[a]=i}),A}const bo=4<<20,GQ=2e5,UQ=40;async function vQ(t,e,n,A,s,r){const o=Wn.get(t);if(o===void 0)throw new Error("This track is no longer open. Drop the file again.");const i={piles:[],total:0,kept:0,capped:!1,rows:0,diffs:"none"},a=m=>{const p=o.refIdOf.get(m);if(p!==void 0)return p;const w=Kt(o.refNames,m);if(!(w<0))return o.refIdOf.set(m,w),w},c=e.filter(m=>a(m.contig)!==void 0&&m.end>m.start);if(c.length===0)return i;const l=c.reduce((m,p)=>m+(p.end-p.start),0);if(l>GQ)return{...i,note:`${ie(l/1e3)} kb — too wide to draw reads`};const g=[];for(const m of c){const p=a(m.contig);g.push({region:m,refId:p,spans:await ec(o,p,m,r,bo)})}const f=g.reduce((m,p)=>m+bi(p.spans),0);if(f>bo)return{...i,note:`${G.bytes(f)} of reads here — zoom in`};const h=[];let u=0,I=0,d=!1,C=0,E=!1,B=!1,Q=!1;for(const m of g){const p=Ac(m.region);p!==void 0&&(Q=!0);for(const w of m.spans){if(!await Ls(r))throw ze();const y=await o.handle.read(w.to-w.from,w.from),N=await Ot(y,w.lastBlock-w.from),k=Hf(N,w.dataFrom,m.region.contig,m.refId,Math.floor(m.region.start),Math.ceil(m.region.end),{filter:SQ(s),maxRows:n,maxReads:TQ,colourBy:s.colourBy,withNames:A<=UQ,refNameOf:b=>o.refNames[b],...p===void 0?{}:{reference:p}});u+=k.total,I+=k.kept,d=d||k.capped,C=Math.max(C,k.rows),E=E||k.usedMd,B=B||k.usedCigar,(k.pile.length>0||h.length===0)&&h.push(k.pile)}}return{piles:h,total:u,kept:I,capped:d,rows:C,diffs:B?"cigar":E?"md":Q?"reference":"none"}}const TQ=2e4,JQ=16;function Ac(t){const e=Math.max(0,Math.floor(t.start));for(const n of re.values()){if(we(n)){const r=Ms(n,t.contig),o=r===void 0?void 0:n.held.get(r.name);if(o===void 0)continue;const i=Math.min(o.start+o.bases.length,Math.ceil(t.end));if(o.start>e||i<=e)continue;return{start:e,bases:o.bases.subarray(e-o.start,i-o.start)}}const A=qn(n,t.contig);if(A===void 0)continue;const s=Math.min(A.length,Math.ceil(t.end));if(!(s<=e))return{start:e,bases:A.subarray(e,s)}}}function vs(t){return`${G.int(t)} sequence${t===1?"":"s"}`}function ie(t){if(!Number.isFinite(t))return"—";const e=Math.abs(t);return e===0?"0":e>=1e3?G.int(Math.round(t)):e>=1?t.toFixed(2).replace(/\.?0+$/,""):t.toPrecision(2)}
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Number.isFinite(o)&&o>0?o:null}catch{return null}}async function hQ(t,e,n,A){const s=Gt(e),r=await s.read(64,0),o=Ha(r);if(o==="bigwig")return bQ(t,e,n);if(o==="bigbed")return kQ(t,e,n);if(We(r)){const I=await ke(s,e),d=await sc(s,I??Number.MAX_SAFE_INTEGER);if(d!==null){if(I===null)throw new Error(`${e.name} cannot be measured — its host states neither Content-Range nor Content-Length to a page — and a BAM is read by byte range.`);return SQ(t,e,s,n,d,I,A)}}if(kn(r))return dA(t,await tc(e,s,A),n);if(Ka(r))return dA(t,await ec(e,s,A),n);if(ds(r))return BQ(s,n);const i=Dt;if(i!==null&&i.key===tt(e)&&i.features!==null)return Dt=null,XA(i.format,i.features,n);const a=await cQ(e,s,r,n),c=a===null?await gs(await s.readFile({onProgress:A})):null;if(c!==null&&kn(c))return dA(t,Us(e,c),n);const l=a??new TextDecoder().decode(c);if(l.trim()==="")throw new Error("This file is empty.");if(Ai(l))return uQ(l,n);if(yA(l,e.name))return IA(l,e.name,n,ki);if(pA(l,e.name))return IA(l,e.name,n);if(Bi(l,e.name))return IA(l,e.name,n,pi);if(hi(l,e.name))return Za(l,e.name,n);if(La(l))return CQ(l,n);if(Ds(l,e.name)!==null)return QQ(l,e.name,n);if(wa(l,e.name))return Xa(l,n);if(Na(l,e.name))return IQ(l,n);if(Da(l,e.name))return dQ(l,n);if(Oa(l,e.name))return Va(t,l,n);const f=Gi(l);if(f!==null)return MQ(t,f,l,n);const h=ii(l,e.name);if(h==="bedpe"){const I=fi(l),d=ft(I.contigs,n);return{format:h,contigs:I.contigs,overlap:Z(I.contigs,n,d),summary:`${x.int(I.length)} pair${I.length===1?"":"s"}`,payload:{kind:"pairs",data:I}}}const u=h==="gtf"?li(l):hs(l,e.name);return XA(h,u,n)}function uQ(t,e){const n=oi(t),A=ft(n.contigs,e),s=og(t);return{format:"vcf",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:`${x.int(n.length)} variant${n.length===1?"":"s"}`+(s===0?"":` · ${x.int(s)} sample${s===1?"":"s"} not drawn`),payload:{kind:"features",data:n}}}function Xa(t,e){const n=pa(t),A=ft(n.contigs,e);return{format:"interact",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:hC(n),payload:{kind:"pairs",data:n}}}function IQ(t,e){const n=ka(t),A=ft(n.contigs,e);return{format:"longrange",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:dC(n),payload:{kind:"pairs",data:n}}}function dQ(t,e){const n=Fa(t),A=ft(n.contigs,e);return{format:"genepred",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:Ms(n),payload:{kind:"features",data:n}}}function Va(t,e,n){const A=Ya(e),s=A.signal,r=pe(s.contigs.map(a=>({name:a.name})),n);s.contigs.forEach((a,c)=>{a.name=r.names[c]});const o=new Ui(s);Hn.set(t,o);const i=o.contigNames;return{format:"bedmethyl",contigs:i,overlap:Z(i,n,r),summary:YC(A),fileExtent:{min:0,max:100}}}function Za(t,e,n){const A=di(t,e),s=ft(A.contigs,n);return{format:"barchart",contigs:A.contigs,overlap:Z(A.contigs,n,s),summary:Og(A),payload:{kind:"features",data:A}}}function CQ(t,e){const n=Ga(t),A=ft(n.contigs,e);return{format:"cytoband",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:xa(n),payload:{kind:"features",data:n}}}function QQ(t,e,n){const A=$a(t,e),s=ft(A.contigs,n);return{format:"junctions",contigs:A.contigs,overlap:Z(A.contigs,n,s),summary:Ja(A),payload:{kind:"features",data:A}}}function IA(t,e,n,A=wi){const s=A(t,e),r=ft(s.contigs,n);return{format:"structure",contigs:s.contigs,overlap:Z(s.contigs,n,r),summary:Ni(s),payload:{kind:"features",data:s}}}async function ja(t){const e=(o,i)=>t.read(o,i),n=await ke(t),A=await sf(e,n??void 0),s=Math.min(...A.resolutions),r=await rf(e,A,s);return Object.assign(r,{header:A})}async function BQ(t,e){const n=await ja(t),A=ft(n.contigs,e),s=n.header.resolutions.filter(o=>o!==n.model?.width),r=[Ni(n),of(n.header),...s.length===0?[]:[`also at ${s.join(", ")} bp`]].join(ct);return{format:"structure",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:r,payload:{kind:"features",data:n}}}function XA(t,e,n){const A=e.exonStart.length,s=ft(e.contigs,n);return{format:t,contigs:e.contigs,overlap:Z(e.contigs,n,s),summary:t==="gtf"?`${x.int(e.length)} transcripts · ${x.int(A)} exons`:t==="genepred"?Ms(e):t==="cytoband"?xa(e):t==="junctions"?Ja(e):`${x.int(e.length)} feature${e.length===1?"":"s"}`,payload:{kind:"features",data:e}}}async function tc(t,e,n){const A=oe;if(A!==null&&A.key===tt(t))return A.store;const s=t.kind==="local"?t.file.size:await ke(e,t),r=s!==null&&s>0;if(r&&s<=HA)return ko(t,e,n);const o=await EQ(t,e);if(o!==null)return oe={key:tt(t),store:o},o;if(r&&s>Ls)throw nc(s,t);return ko(t,e,n)}async function ko(t,e,n){return Us(t,await gs(await e.readFile({onProgress:n})))}async function EQ(t,e){const n=t.index!==void 0?t:t.kind==="remote"&&ma.test(t.url)?{...t,index:AC(t.url)}:null,A=n===null?null:vs(n);if(A===null)return null;try{const s=jd(new TextDecoder().decode(await Gt(A).readFile()));return s.length===0?null:{indexed:!0,contigs:tC(s),records:new Map(s.map(r=>[r.name,r])),handle:e,total:s.reduce((r,o)=>r+o.length,0),held:new Map}}catch{return null}}async function ec(t,e,n){const A=oe;if(A!==null&&A.key===tt(t)&&_t(A.store))return A.store;const s=await ke(e),r=await VC((i,a)=>e.read(i,a,{onProgress:n}),s??void 0),o={twobit:!0,contigs:XC(r.ordered),records:r.records,handle:e,total:r.total,held:new Map};return oe={key:tt(t),store:o},o}function Us(t,e){if(e.length>Ls)throw nc(e.length,t);const n=$f(e);if(n.contigs.length===0)throw new Error("This looks like a FASTA but holds no sequences.");return oe={key:tt(t),store:n},n}function nc(t,e){const n=e.name.replace(/[#?].*$/,"")||"genome.fa";return new Error(`This FASTA is ${x.int(Math.round(t/1e6))} MB and has no index. It would be read whole and held whole — which is what makes panning free — so anything over ${x.int(Ls/1e6)} MB is refused rather than allowed to take the tab with it. Index it (\`samtools faidx ${n}\`) and ${e.kind==="local"?"drop the .fai with it":"publish the .fai beside it, or name it with #index=<url>"}: an indexed FASTA opens at once and is read by range.`)}function dA(t,e,n){const A=wQ(e,n);re.set(t,e);const s=e.contigs.map(r=>r.name);return{format:_t(e)?"twobit":"fasta",contigs:s,overlap:Z(s,n,A),summary:`${Ts(s.length)} · ${x.bp(e.total)}`+(_t(e)?" · read by range, two bits a base":Rs(e)?" · read by range from its index":""),...we(e)?{byRange:{bases:e.total,bytesPerBase:mQ(e)}}:{}}}function mQ(t){if(_t(t))return .25;let e=0,n=0;for(const A of t.records.values())e+=A.length*A.lineWidth/A.lineBases,n+=A.length;return n>0?e/n:1}function wQ(t,e){const n=pe(t.contigs,e);if(n.renamed===0)return n;if(_t(t)||Rs(t))return t.records=bo(t.records,t.contigs,n.names),t.held.clear(),n;const A=new Map;return t.contigs.forEach((s,r)=>{const o=t.bases.get(s.name);s.name=n.names[r],o!==void 0&&A.set(s.name,o)}),t.bases=A,n}function bo(t,e,n){const A=new Map;return e.forEach((s,r)=>{const o=t.get(s.name);s.name=n[r],o!==void 0&&A.set(s.name,{...o,name:s.name})}),A}async function pQ(t,e,n,A){const s=[];let r=Number.POSITIVE_INFINITY,o=Number.NEGATIVE_INFINITY;if(we(t)&&e.reduce((a,c)=>a+Math.max(0,c.end-c.start),0)>No)return{basesPerPixel:n,regions:[],extent:null,note:`GC under ${x.int(No/1e6)} Mb, letters at base resolution — zoom in`};for(const i of e){if(!(i.end>i.start))continue;let a;if(we(t)){const c=Math.max(0,Math.floor(i.start)),l=await Wa(t,i.contig,c,i.end,A);if(l===void 0||l.length===0)continue;a=Br(l,0,l.length,n);for(let g=0;g<a.starts.length;g++)a.starts[g]+=c,a.ends[g]+=c}else{const c=qn(t,i.contig);if(c===void 0)continue;a=Br(c,i.start,i.end,n)}if(a.values.length!==0){for(const c of a.values)Number.isFinite(c)&&(c<r&&(r=c),c>o&&(o=c));s.push({contig:i.contig,start:i.start,end:i.end,starts:a.starts,ends:a.ends,values:a.values,min:null,max:null,variant:null,summary:!0})}}return{basesPerPixel:n,regions:s,extent:r<=o?{min:r,max:o}:null}}const yQ=4e5;async function NQ(t,e,n){const A=re.get(t);if(A===void 0)throw new Error("This sequence is no longer open. Drop the file again.");const s=[];let r=yQ;for(const o of e){const i=Math.max(0,Math.floor(o.start));if(we(A)){const l=await Wa(A,o.contig,i,Math.min(Math.ceil(o.end),i+r),n);if(l===void 0||l.length===0)continue;if(r-=l.length,s.push({contig:o.contig,start:i,end:i+l.length,bases:l.slice()}),r<=0)break;continue}const a=qn(A,o.contig);if(a===void 0)continue;const c=Math.min(a.length,Math.ceil(o.end),i+r);if(c>i&&(r-=c-i,s.push({contig:o.contig,start:i,end:c,bases:a.slice(i,c)}),r<=0))break}return{regions:s}}const VA=1e6;async function kQ(t,e,n){const A=new Yo({filehandle:Gt(e)}),s=await A.getHeader(),r=xs(s),o=[];let i=!1;for(const f of r){if(o.length>=VA){i=!0;break}const h=await A.getFeatures(f.name,0,f.length);for(const u of h){if(o.length>=VA){i=!0;break}const I=typeof u.rest=="string"&&u.rest!==""?`	${u.rest}`:"";o.push(`${f.name}	${u.start}	${u.end}${I}`)}}const a=o.join(`
+`),c=s.autoSql??"";if(Jg(c)){const f=Za(a,e.name,n);return i?{...f,summary:Le(f.summary)}:f}if(fC(c)){const f=Xa(a,n);return i?{...f,summary:Le(f.summary)}:f}if(OC(c)){const f=Va(t,a,n);return i?{...f,summary:Le(f.summary)}:f}const l=hs(a,e.name);if(NC(c)){const f=ft(l.contigs,n),h={format:"genepred",contigs:l.contigs,overlap:Z(l.contigs,n,f),summary:Ms(l),payload:{kind:"features",data:l}};return i?{...h,summary:Le(h.summary)}:h}const g=XA("bigbed",l,n);return{...g,summary:i?Le(g.summary):g.summary}}function Le(t){return`${t} · cut off at ${x.int(VA)}`}async function bQ(t,e,n){const A=new Jo({filehandle:Gt(e)}),s=await A.getHeader(),r=pe(xs(s),n),o=r.names;Ss.set(t,{bigwig:A,refOf:r.sourceOf,refNames:Object.keys(s.refsByName)});const i=s.totalSummary,a=i!==void 0&&Number.isFinite(i.scoreMin)&&Number.isFinite(i.scoreMax)&&i.scoreMax>i.scoreMin;return{format:"bigwig",contigs:o,overlap:Z(o,n,r),summary:Ts(o.length)+(a?` · ${ie(i.scoreMin)}–${ie(i.scoreMax)}`:""),...a?{fileExtent:{min:i.scoreMin,max:i.scoreMax}}:{}}}function MQ(t,e,n,A){const s=e==="wig"?vi(n):xi(n);if(s.length===0)throw new Error(`This looks like a ${e==="wig"?"wig":"bedGraph"} but holds no usable intervals.`);const r=pe(s.contigs.map(g=>({name:g.name})),A);s.contigs.forEach((g,f)=>{g.name=r.names[f]});const o=new Ui(s);Hn.set(t,o);const i=o.contigNames,{min:a,max:c}=o.extent,l=Number.isFinite(a)&&Number.isFinite(c)&&c>a;return{format:e,contigs:i,overlap:Z(i,A,r),summary:`${x.int(o.length)} intervals · ${Ts(i.length)}`+(l?` · ${ie(a)}–${ie(c)}`:""),...l?{fileExtent:{min:a,max:c}}:{}}}function DQ(t,e,n){const A=[];let s=Number.POSITIVE_INFINITY,r=Number.NEGATIVE_INFINITY;for(const o of e){if(!t.has(o.contig)||o.end<=o.start)continue;const i=t.samples(o.contig,o.start,o.end,n);if(i!==null){for(const a of i.values)Number.isFinite(a)&&(a<s&&(s=a),a>r&&(r=a));A.push({contig:o.contig,start:o.start,end:o.end,variant:null,...i})}}return{basesPerPixel:n,regions:A,extent:s<=r?{min:s,max:r}:null}}async function Ac(t,e,n,A,s,r=!1){const o=Wn.get(t);if(o!==void 0)return UQ(s,o,e,n,A);const i=re.get(t);if(i!==void 0)return pQ(i,e,n,Qn(s));const a=Hn.get(t);if(a!==void 0)return DQ(a,e,n);const c=qA.get(t);if(c!==void 0)return Gh(c,e,n,r);const l=Ss.get(t);if(l===void 0)throw new Error("This track is no longer open. Drop the file again.");const g=C=>{const B=l.refOf.get(C);if(B!==void 0)return B;const Q=Kt(l.refNames,C);if(!(Q<0))return l.refOf.set(C,l.refNames[Q]),l.refNames[Q]},f=e.filter(C=>g(C.contig)!==void 0&&C.end>C.start);if(f.length===0)return{basesPerPixel:n,regions:[],extent:null};const h=await l.bigwig.getFeaturesAsArraysMulti(f.map(C=>({refName:g(C.contig)??C.contig,start:Math.max(0,Math.floor(C.start)),end:Math.ceil(C.end)})),{basesPerSpan:Math.max(1,n)}),u=[];let I=Number.POSITIVE_INFINITY,d=Number.NEGATIVE_INFINITY;for(let C=0;C<f.length;C++){const B=h.regionOffsets[C],Q=h.regionOffsets[C+1],E=h.scores.slice(B,Q);for(let m=0;m<E.length;m++){const p=E[m];Number.isFinite(p)&&(p<I&&(I=p),p>d&&(d=p))}u.push({contig:f[C].contig,start:f[C].start,end:f[C].end,starts:h.starts.slice(B,Q),ends:h.ends.slice(B,Q),values:E,min:h.isSummary?h.minScores.slice(B,Q):null,max:h.isSummary?h.maxScores.slice(B,Q):null,variant:null,summary:h.isSummary})}return{basesPerPixel:n,regions:u,extent:I<=d?{min:I,max:d}:null}}const FQ=1<<18,Mo=1<<24;async function sc(t,e){const n=Number.isFinite(e)&&e>0?e:Number.MAX_SAFE_INTEGER;let A=FQ;for(;;){let s;try{s=await Yt(await t.read(Math.min(A,n),0))}catch{return null}if(!ti(s))return null;const r=Sl(s);if(r!==null)return r;if(A>=n||A>=Mo)throw new Error("This BAM's header is truncated: its reference table does not end.");A=Math.min(A*4,Mo)}}async function SQ(t,e,n,A,s,r,o){if(s.sortOrder==="queryname"||s.sortOrder==="unsorted")throw new Error(`${e.name} is sorted by ${s.sortOrder==="queryname"?"read name":"nothing"}, and reads are drawn by region. Run \`samtools sort -o sorted.bam ${e.name}\` and index the result.`);const i=vs(e),a=i===null?`${tt(e)}|search`:nQ(e,i),c=Un.get(a);let l=null,g=null,f="";if(c!==void 0)l=c.open.index,g=c.open.search,f=c.open.searched;else{if(i===null)f="no index dropped with it";else try{l=await Bf(await Gt(i).readFile({onProgress:o}))}catch(C){const B=C instanceof Error?C.message:String(C);f=i.kind==="remote"?`no ${i.url.split("?")[0].split("/").pop()??"index"} beside it`:`${i.name} could not be read (${B})`}if(l===null){if(!Number.isFinite(r)||r<=0)throw new Error(`${e.name} has ${f}, and its length could not be learnt, so its reads cannot be located by search either. A BAM is read by region: publish its index beside it, or name one with \`${e.kind==="remote"?e.url:e.name}#index=<url of the .bai>\`.`);try{g=await Cs.open(n,r,s,C=>o(C,0))}catch(C){if(C instanceof NA)throw new Error(RQ(e.name,s,C));const B=C instanceof Error?C.message:String(C);throw new Error(`${e.name} has ${f} and could not be read by search: ${B}. A BAM is read by region; run \`samtools index ${e.name}\` and publish the index beside it, or name one with \`#index=<url of the .bai>\`.`)}}}const h=pe(s.refs,A),u=h.names,I=new Map;for(let C=0;C<u.length;C++)I.set(u[C],C);for(let C=0;C<s.refs.length;C++)I.has(s.refs[C].name)||I.set(s.refs[C].name,C);const d=c?.open??{handle:n,header:s,index:l,search:g,searched:f,size:r,refIdOf:I,refNames:s.refs.map(C=>C.name)};return c===void 0?Un.set(a,{open:d,holders:new Set([t])}):c.holders.add(t),Wn.set(t,d),{format:"bam",contigs:u,overlap:Z(u,A,h),summary:`${x.int(s.refs.length)} reference${s.refs.length===1?"":"s"} · ${l!==null?l.format.toUpperCase():`${f} — reads located by search`}`}}function RQ(t,e,n){const A=e.sortOrder==="coordinate"?"its header says SO:coordinate, but":"its header has no @HD line to say so, and";return`${t} is not in coordinate order — ${A} the reads at byte ${x.int(n.before.block)} are on ${dr(n.before,e.refs)} while those at byte ${x.int(n.after.block)}, later in the file, are on ${dr(n.after,e.refs)}. Reads are drawn by region, which needs the file sorted and indexed: run \`samtools sort -o sorted.bam ${t}\` and \`samtools index sorted.bam\`. The alignment file a Hi-C pipeline writes is in read-pair order for its pairs step and is not made for browsing; its .pairs or its contact map is the file to open.`}const LQ=4e6;function GQ(t,e){if(t.search===null)return null;const n=e.reduce((A,s)=>A+(s.end-s.start),0);return e.length>1||n>LQ?`${xQ(n)} without an index — zoom in`:null}function xQ(t){return t>=1e6?`${ie(t/1e6)} Mb`:`${ie(t/1e3)} kb`}async function rc(t,e,n,A,s){const r=Math.max(0,Math.floor(n.start)),o=Math.ceil(n.end);return t.index!==null?kf(t.index,e,r,o,t.size):t.search===null?[]:t.search.spansFor(e,r,o,async()=>{if(!await Gs(A))throw ze()},s)}function oc(t){return t===void 0?Ri:{exclude:jo|(t.hideDuplicates?At.DUPLICATE:0),minMapq:t.minMapq}}function vQ(t){const e=oc(t);return t.splits?{...e,exclude:e.exclude&-2049}:e}async function UQ(t,e,n,A,s){const r=I=>{const d=e.refIdOf.get(I);if(d!==void 0)return d;const C=Kt(e.refNames,I);if(!(C<0))return e.refIdOf.set(I,C),C},o=n.filter(I=>r(I.contig)!==void 0&&I.end>I.start);if(o.length===0)return{basesPerPixel:A,regions:[],extent:null};const i=GQ(e,o);if(i!==null)return{basesPerPixel:A,regions:[],extent:null,note:i};const a=[];for(const I of o){const d=r(I.contig);a.push({region:I,refId:d,spans:await rc(e,d,I,t,yo)})}const c=a.reduce((I,d)=>I+Fi(d.spans),0);if(c>yo)return{basesPerPixel:A,regions:[],extent:null,note:`${x.bytes(c)} of reads — zoom in`};const l=[];let g=Number.POSITIVE_INFINITY,f=Number.NEGATIVE_INFINITY;const h=s?.modFraction===!0,u=[];for(const I of a){const d=I.region.end-I.region.start,C=Math.max(1,Math.min(4096,Math.round(d/Math.max(1,A)))),B=new Float64Array(C),Q=new Map;u.push(Q);const E=A<=KQ?ic(I.region):void 0,m=E===void 0?null:new Float64Array(C),p=new Map;for(const M of I.spans){if(!await Gs(t))throw ze();const F=await e.handle.read(M.to-M.from,M.from),S=await Yt(F,M.lastBlock-M.from),v=Yf(S,M.dataFrom,I.refId,Math.floor(I.region.start),Math.ceil(I.region.end),C,oc(s),E,p,h?{tally:Q,threshold:s.modThreshold}:void 0);for(let G=0;G<C;G++)B[G]+=v.depth[G];if(m!==null&&v.variant!==null)for(let G=0;G<C;G++)m[G]+=v.variant[G]}const w=new Int32Array(C),y=new Int32Array(C),N=new Float32Array(C),k=m===null?null:new Float32Array(C),b=d/C;for(let M=0;M<C;M++)w[M]=Math.round(I.region.start+M*b),y[M]=Math.round(I.region.start+(M+1)*b),N[M]=B[M],k!==null&&m!==null&&(k[M]=m[M]),B[M]<g&&(g=B[M]),B[M]>f&&(f=B[M]);l.push({contig:I.region.contig,start:I.region.start,end:I.region.end,starts:w,ends:y,values:N,variant:k,junctions:$Q(p),min:null,max:null,summary:!1})}return h?TQ(A,l,u,s.modCode):{basesPerPixel:A,regions:l,extent:g<=f&&f>0?{min:0,max:f}:null}}function TQ(t,e,n,A){const s=new Map;for(const c of n)for(const[l,g]of c){const f=s.get(l)??[0,0];f[0]+=g.modified.reduce((h,u)=>h+u,0),f[1]+=g.calls.reduce((h,u)=>h+u,0),s.set(l,f)}const r=[...s.entries()].sort((c,l)=>l[1][0]-c[1][0]||l[1][1]-c[1][1]).map(([c])=>c),o=A!==""?A:r[0]??"";let i=!1;const a=e.map((c,l)=>{const g=n[l].get(o),f=new Float32Array(c.values.length).fill(Number.NaN);if(g!==void 0)for(let h=0;h<f.length;h++)g.calls[h]<=0||(f[h]=100*g.modified[h]/g.calls[h],i=!0);return{...c,values:f,variant:null,junctions:void 0}});return{basesPerPixel:t,regions:a,extent:i?{min:0,max:100}:null,mods:{code:o,codes:r},...r.length===0?{note:"no MM/ML modification calls here"}:{}}}function $Q(t){const e=[];for(const[s,r]of t){const[o,i,a]=s.split(":").map(Number);e.push([o,i,a,r])}e.sort((s,r)=>s[0]-r[0]||s[1]-r[1]||s[2]-r[2]);const n=e.length,A={starts:new Int32Array(n),ends:new Int32Array(n),counts:new Float32Array(n),strands:new Int8Array(n)};return e.forEach(([s,r,o,i],a)=>{A.starts[a]=s,A.ends[a]=r,A.strands[a]=o,A.counts[a]=i}),A}const Do=4<<20,JQ=2e5,OQ=40;async function YQ(t,e,n,A,s,r){const o=Wn.get(t);if(o===void 0)throw new Error("This track is no longer open. Drop the file again.");const i={piles:[],total:0,kept:0,capped:!1,rows:0,diffs:"none"},a=m=>{const p=o.refIdOf.get(m);if(p!==void 0)return p;const w=Kt(o.refNames,m);if(!(w<0))return o.refIdOf.set(m,w),w},c=e.filter(m=>a(m.contig)!==void 0&&m.end>m.start);if(c.length===0)return i;const l=c.reduce((m,p)=>m+(p.end-p.start),0);if(l>JQ)return{...i,note:`${ie(l/1e3)} kb — too wide to draw reads`};const g=[];for(const m of c){const p=a(m.contig);g.push({region:m,refId:p,spans:await rc(o,p,m,r,Do)})}const f=g.reduce((m,p)=>m+Fi(p.spans),0);if(f>Do)return{...i,note:`${x.bytes(f)} of reads here — zoom in`};const h=[];let u=0,I=0,d=!1,C=0,B=!1,Q=!1,E=!1;for(const m of g){const p=ic(m.region);p!==void 0&&(E=!0);for(const w of m.spans){if(!await Gs(r))throw ze();const y=await o.handle.read(w.to-w.from,w.from),N=await Yt(y,w.lastBlock-w.from),k=zf(N,w.dataFrom,m.region.contig,m.refId,Math.floor(m.region.start),Math.ceil(m.region.end),{filter:vQ(s),maxRows:n,maxReads:_Q,colourBy:s.colourBy,withNames:A<=OQ,refNameOf:b=>o.refNames[b],...p===void 0?{}:{reference:p}});u+=k.total,I+=k.kept,d=d||k.capped,C=Math.max(C,k.rows),B=B||k.usedMd,Q=Q||k.usedCigar,(k.pile.length>0||h.length===0)&&h.push(k.pile)}}return{piles:h,total:u,kept:I,capped:d,rows:C,diffs:Q?"cigar":B?"md":E?"reference":"none"}}const _Q=2e4,KQ=16;function ic(t){const e=Math.max(0,Math.floor(t.start));for(const n of re.values()){if(we(n)){const r=Fs(n,t.contig),o=r===void 0?void 0:n.held.get(r.name);if(o===void 0)continue;const i=Math.min(o.start+o.bases.length,Math.ceil(t.end));if(o.start>e||i<=e)continue;return{start:e,bases:o.bases.subarray(e-o.start,i-o.start)}}const A=qn(n,t.contig);if(A===void 0)continue;const s=Math.min(A.length,Math.ceil(t.end));if(!(s<=e))return{start:e,bases:A.subarray(e,s)}}}function Ts(t){return`${x.int(t)} sequence${t===1?"":"s"}`}function ie(t){if(!Number.isFinite(t))return"—";const e=Math.abs(t);return e===0?"0":e>=1e3?x.int(Math.round(t)):e>=1?t.toFixed(2).replace(/\.?0+$/,""):t.toPrecision(2)}