chromosomix 0.16.0 → 0.17.0

package/dist/assets/annotations.worker-B-6-la1Q.js

@@ -0,0 +1,28 @@
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A=0;A<t.length;A++){const s=t[A];e[A]=s.offset,n[A]=s.length}return{inputOffsets:e,inputLengths:n}}async function Dc(t,e,n){const{inputOffsets:A,inputLengths:s}=jA(e);return pc(t,A,s,n)}async function Mc(t,e,n,A,s){const{inputOffsets:r,inputLengths:o}=jA(e);return kc(t,r,o,n,A,s)}async function Fc(t,e,n,A,s,r){const{inputOffsets:o,inputLengths:i}=jA(e);return bc(t,o,i,n,A,s,r)}const ts=new TextDecoder("utf8");function rt(t,e=0){return new DataView(t.buffer,t.byteOffset+e,t.length-e)}function j(t,e){return t.getUint32(e,!0)+t.getUint32(e+4,!0)*2**32}function uA(t,e,n){const A=t.indexOf(0,e),s=A!==-1&&A<e+n?A:e+n;return ts.decode(t.subarray(e,s))}function Sc(t){const e=t.toSorted((s,r)=>s.offset-r.offset),n=[];let A;for(const s of e)A&&s.offset-(A.offset+A.length)<=2e3?(A.length=Math.max(A.length,s.offset+s.length-A.offset),A.blocks.push(s)):(A={blocks:[s],length:s.length,offset:s.offset},n.push(A));return n}const Js=610839776;function Rc(t,e){let n=0;for(const s of t)n+=s.length;let A=0;return e?.(0,n),s=>{A+=s,e?.(A,n)}}function ue(t,e,n,A){return t<A&&e>n}function Fo(t,e){return e?t/e:t}function Lc(t,e){const n=[];let A=0;const s=rt(t);for(;A<t.byteLength;){const r=s.getUint32(A,!0);A+=4;const o=s.getUint32(A,!0);A+=4;const i=s.getUint32(A,!0);A+=4;const a=s.getUint32(A,!0);A+=4;const c=s.getFloat32(A,!0);A+=4;const l=s.getFloat32(A,!0);A+=4;const g=s.getFloat32(A,!0);A+=8,(!e||r===e.chrId&&ue(o,i,e.start,e.end))&&n.push({start:o,end:i,maxScore:l,minScore:c,summary:!0,score:Fo(g,a)})}return n}function xc(t,e,n){const A=[];let s=0;const r=rt(t);for(;s<t.byteLength;){const o=s,i=r.getUint32(s,!0);s+=4;const a=r.getInt32(s,!0);s+=4;const c=r.getInt32(s,!0);s+=4;const l=t.indexOf(0,s),g=l===-1?t.length:l,f=ts.decode(t.subarray(s,g));s=g+1,(!n||i===n.chrId&&ue(a,c,n.start,n.end))&&A.push({start:a,end:c,rest:f,uniqueId:`bb-${e}-${o}`})}return A}function Gc(t,e){const n=rt(t),A=n.getInt32(4,!0),s=n.getUint32(12,!0),r=n.getUint32(16,!0),o=n.getUint8(20),i=n.getUint16(22,!0);let a=24;const c=[];switch(o){case 1:{for(let l=0;l<i;l++){const g=n.getInt32(a,!0);a+=4;const f=n.getInt32(a,!0);a+=4;const h=n.getFloat32(a,!0);a+=4,(!e||ue(g,f,e.start,e.end))&&c.push({start:g,end:f,score:h})}break}case 2:{for(let l=0;l<i;l++){const g=n.getInt32(a,!0);a+=4;const f=n.getFloat32(a,!0);a+=4;const h=g+r;(!e||ue(g,h,e.start,e.end))&&c.push({score:f,start:g,end:h})}break}case 3:{for(let l=0;l<i;l++){const g=n.getFloat32(a,!0);a+=4;const f=A+l*s,h=f+r;(!e||ue(f,h,e.start,e.end))&&c.push({score:g,start:f,end:h})}break}}return c}function $s(t,e){const n=rt(t),A=n.getInt32(4,!0),s=n.getUint32(12,!0),r=n.getUint32(16,!0),o=n.getUint8(20),i=n.getUint16(22,!0),a=new Int32Array(i),c=new Int32Array(i),l=new Float32Array(i),g=e.start,f=e.end;let h=0;switch(o){case 1:{let u=24;for(let I=0;I<i;I++){const d=n.getInt32(u,!0),C=n.getInt32(u+4,!0);d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u+8,!0),h++),u+=12}break}case 2:{let u=24;for(let I=0;I<i;I++){const d=n.getInt32(u,!0),C=d+r;d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u+4,!0),h++),u+=8}break}case 3:{let u=24;for(let I=0;I<i;I++){const d=A+I*s,C=d+r;d<f&&C>g&&(a[h]=d,c[h]=C,l[h]=n.getFloat32(u,!0),h++),u+=4}break}}return h<i?{starts:a.subarray(0,h),ends:c.subarray(0,h),scores:l.subarray(0,h)}:{starts:a,ends:c,scores:l}}function Ys(t,e){const n=rt(t),A=Math.floor(t.byteLength/32),s=new Int32Array(A),r=new Int32Array(A),o=new Float32Array(A),i=new Float32Array(A),a=new Float32Array(A);let c=0,l=0;for(;l<t.byteLength;){const g=n.getUint32(l,!0);l+=4;const f=n.getUint32(l,!0);l+=4;const h=n.getUint32(l,!0);l+=4;const u=n.getUint32(l,!0);l+=4;const I=n.getFloat32(l,!0);l+=4;const d=n.getFloat32(l,!0);l+=4;const C=n.getFloat32(l,!0);l+=8,g===e.chrId&&ue(f,h,e.start,e.end)&&(s[c]=f,r[c]=h,o[c]=Fo(C,u),i[c]=I,a[c]=d,c++)}return c<A?{starts:s.subarray(0,c),ends:r.subarray(0,c),scores:o.subarray(0,c),minScores:i.subarray(0,c),maxScores:a.subarray(0,c)}:{starts:s,ends:r,scores:o,minScores:i,maxScores:a}}function Ue(t,e,n,A){if(t.length===1)return e(t[0]);const s=new A(n);let r=0;for(const o of t){const i=e(o);s.set(i,r),r+=i.length}return s}function So(t){let e=0;for(const n of t)e+=n.starts.length;return e}function Ro(t){const e=So(t);return{starts:Ue(t,n=>n.starts,e,Int32Array),ends:Ue(t,n=>n.ends,e,Int32Array),scores:Ue(t,n=>n.scores,e,Float32Array),isSummary:!1}}function Uc(t){const e=So(t),{starts:n,ends:A,scores:s}=Ro(t);return{starts:n,ends:A,scores:s,minScores:Ue(t,r=>r.minScores,e,Float32Array),maxScores:Ue(t,r=>r.maxScores,e,Float32Array),isSummary:!0}}function Lo(t){let e=0;for(const i of t)for(const a of i)e+=a.starts.length;const n=new Int32Array(e),A=new Int32Array(e),s=new Float32Array(e),r=[0];let o=0;for(const i of t){for(const a of i)n.set(a.starts,o),A.set(a.ends,o),s.set(a.scores,o),o+=a.starts.length;r.push(o)}return{starts:n,ends:A,scores:s,regionOffsets:r,totalCount:e}}function vc(t){const{starts:e,ends:n,scores:A,regionOffsets:s}=Lo(t);return{starts:e,ends:n,scores:A,regionOffsets:s,isSummary:!1}}function Tc(t){const{starts:e,ends:n,scores:A,regionOffsets:s,totalCount:r}=Lo(t),o=new Float32Array(r),i=new Float32Array(r);let a=0;for(const c of t)for(const l of c)o.set(l.minScores,a),i.set(l.maxScores,a),a+=l.starts.length;return{starts:e,ends:n,scores:A,minScores:o,maxScores:i,regionOffsets:s,isSummary:!0}}function Os(t,e,n,A){switch(t){case"summary":return Lc(e,A);case"bigwig":return Gc(e,A);case"bigbed":return xc(e,n,A)}}class Jc{rTreePromise;rTreeNodeCache=new Cn({cache:new cc({maxSize:1e3}),fill:async({length:e,offset:n},A)=>this.bbi.read(e,n,{signal:A})});bbi;refsByName;rTreeOffset;uncompressBufSize;blockType;constructor(e,n,A,s,r){if(!(A>=0))throw new Error("invalid rTreeOffset!");this.bbi=e,this.refsByName=n,this.rTreeOffset=A,this.uncompressBufSize=s,this.blockType=r}async _collectBlocks(e,n,A,s){const r=this.refsByName[e];if(r===void 0||n>=A)return;this.rTreePromise||(this.rTreePromise=this.bbi.read(48,this.rTreeOffset,{signal:s?.signal}).catch(u=>{throw this.rTreePromise=void 0,u}));const o=await this.rTreePromise,i=rt(o),a=i.getUint32(0,!0);if(a!==Js)throw new Error(`invalid cirTree magic: 0x${a.toString(16)} (expected 0x${Js.toString(16)}) at offset ${this.rTreeOffset}, file may be corrupt or unsupported`);const l=4+i.getUint32(4,!0)*32,g=(u,I,d,C)=>(u<r||u===r&&I<A)&&(d>r||d===r&&C>n),f=[];let h=[this.rTreeOffset+48];for(;h.length>0;){const u=lc(h.map(d=>({min:d,max:d+l}))),I=[];for(const{min:d,max:C}of u){const E=C-d,B=d,Q=await this.rTreeNodeCache.get(`${E}_${B}`,{length:E,offset:B},s?.signal);for(const m of h)if(d<=m&&m<=C){const p=Q.subarray(m-B),w=rt(p),y=w.getUint8(0),N=w.getUint16(2,!0);if(y===1||y===0){const k=y===1?32:24;let b=4;for(let D=0;D<N;D++){const F=w.getUint32(b,!0),R=w.getUint32(b+4,!0),v=w.getUint32(b+8,!0),x=w.getUint32(b+12,!0);if(g(F,R,v,x)){const Y=j(w,b+16);if(y===1){const J=j(w,b+24);f.push({offset:Y,length:J})}else I.push(Y)}b+=k}}}}h=I}return{blocks:f,chrId:r}}async readWigData(e,n,A,s){const r=await this._collectBlocks(e,n,A,s);if(!r)return[];const{blocks:o,chrId:i}=r;return this.readFeatures(o,{...s,request:{chrId:i,start:n,end:A}})}async getBlockSizeForRange(e,n,A,s){const r=await this._collectBlocks(e,n,A,s);let o=0;if(r)for(const i of r.blocks)o+=i.length;return o}async getBlockSizeForRangeMulti(e,n={}){const{blockByOffset:A}=await this._collectBlocksMulti(e,n);let s=0;for(const r of A.values())s+=r.length;return s}async _collectBlocksMulti(e,n){const A=await Promise.all(e.map(({refName:o,start:i,end:a})=>this._collectBlocks(o,i,a,n))),s=new Map,r=new Map;for(let o=0;o<A.length;o++){const i=A[o];if(i){const{start:a,end:c}=e[o],l={chrId:i.chrId,start:a,end:c};for(const g of i.blocks){const f=r.get(g.offset);f?f.push({regionIndex:o,request:l}):(s.set(g.offset,g),r.set(g.offset,[{regionIndex:o,request:l}]))}}}return{blockByOffset:s,tagsByOffset:r}}async readWigDataMulti(e,n={}){const A=e.map(()=>[]),{blockByOffset:s,tagsByOffset:r}=await this._collectBlocksMulti(e,n),{blockType:o}=this;return await this._forEachDecodedBlock([...s.values()],n.signal,n.onProgress,(i,a)=>{const c=r.get(a);if(c)for(const{regionIndex:l,request:g}of c){const f=Os(o,i,a,g);for(const h of f)A[l].push(h)}}),A}assertNotBigBed(e){if(this.blockType==="bigbed")throw new Error(`${e} is not supported for BigBed data; use getFeatures/getFeaturesMulti instead`)}async readWigDataAsArrays(e,n,A,s){this.assertNotBigBed("getFeaturesAsArrays");const r=await this._collectBlocks(e,n,A,s),o=r?r.blocks:[],i={chrId:r?r.chrId:0,start:n,end:A};return this.blockType==="summary"?this._readSummaryFeaturesAsArrays(o,i,s):this._readBigWigFeaturesAsArrays(o,i,s)}async readWigDataAsArraysMulti(e,n={}){this.assertNotBigBed("getFeaturesAsArraysMulti");const A=await this._collectBlocksMulti(e,n);return this.blockType==="summary"?Tc(await this._readBlocksAsArraysMulti(A,e.length,(s,r)=>Ys(s,r),n)):vc(await this._readBlocksAsArraysMulti(A,e.length,(s,r)=>$s(s,r),n))}async _readBlocksAsArraysMulti(e,n,A,s){const{blockByOffset:r,tagsByOffset:o}=e,i=Array.from({length:n},()=>[]);return await this._forEachDecodedBlock([...r.values()],s.signal,s.onProgress,(a,c)=>{const l=o.get(c);if(l)for(const{regionIndex:g,request:f}of l){const h=A(a,f);h.starts.length>0&&i[g].push(h)}}),i}async _forEachBlockGroup(e,n,A,s){const r=Sc(e),o=Rc(r,A);for(const i of r){const a=await this.bbi.read(i.length,i.offset,{signal:n});o(i.length),await s(a,i.blocks.map(c=>({offset:c.offset-i.offset,length:c.length})),i.offset)}}async _forEachDecodedBlock(e,n,A,s){const{uncompressBufSize:r}=this;await this._forEachBlockGroup(e,n,A,async(o,i,a)=>{if(r>0){const{data:c,offsets:l}=await Dc(o,i,r);for(let g=0;g<i.length;g++)s(c.subarray(l[g],l[g+1]),a+i[g].offset)}else for(const c of i)s(o.subarray(c.offset,c.offset+c.length),a+c.offset)})}async readFeatures(e,n={}){const{blockType:A}=this,{signal:s,request:r,onProgress:o}=n,i=[];return await this._forEachDecodedBlock(e,s,o,(a,c)=>{const l=Os(A,a,c,r);for(const g of l)i.push(g)}),i}async _readBlocksAsArrays(e,n,A,s,r){const{uncompressBufSize:o}=this,i=[],a=c=>{c.starts.length>0&&i.push(c)};return await this._forEachBlockGroup(e,n,r,async(c,l)=>{if(o>0)a(await A(c,l));else for(const g of l)a(s(c.subarray(g.offset,g.offset+g.length)))}),i}async _readBigWigFeaturesAsArrays(e,n,A={}){const s=await this._readBlocksAsArrays(e,A.signal,(r,o)=>Mc(r,o,this.uncompressBufSize,n.start,n.end),r=>$s(r,n),A.onProgress);return Ro(s)}async _readSummaryFeaturesAsArrays(e,n,A={}){const s=await this._readBlocksAsArrays(e,A.signal,(r,o)=>Fc(r,o,this.uncompressBufSize,n.chrId,n.start,n.end),r=>Ys(r,n),A.onProgress);return Uc(s)}}const $c=-2003829722,_s=-2021002517;class xo{bbi;headerP;getHeader(e){return this.headerP||(this.headerP=this._getHeader(e).catch(n=>{throw this.headerP=void 0,n})),this.headerP}constructor(e){const{filehandle:n,path:A,url:s}=e;if(n)this.bbi=n;else if(s)this.bbi=new No(s);else if(A)this.bbi=new rc(A);else throw new Error("no file given")}async _getHeader(e){const n=await this._getMainHeader(e),A=await this._readChromosomeTree(n,e);return{...n,...A}}async _getMainHeader(e,n=2e3){const A=await this.bbi.read(n,0,e),s=rt(A);let r=0;const o=s.getInt32(r,!0);if(r+=4,o!==$c&&o!==_s)throw new Error("not a BigWig/BigBed file");const i=s.getUint16(r,!0);r+=2;const a=s.getUint16(r,!0);r+=2;const c=j(s,r);r+=8;const l=j(s,r);r+=8;const g=j(s,r);r+=8;const f=s.getUint16(r,!0);r+=2;const h=s.getUint16(r,!0);r+=2;const u=j(s,r);r+=8;const I=j(s,r);r+=8;const d=s.getUint32(r,!0);r+=4;const C=j(s,r);r+=8;const E=[];for(let y=0;y<a;y++){const N=s.getUint32(r,!0);r+=4,r+=4;const k=j(s,r);r+=8;const b=j(s,r);r+=8,E.push({reductionLevel:N,dataOffset:k,indexOffset:b})}const B=o===_s?"bigbed":"bigwig",Q=A.length<n,m=u!==0&&!A.includes(0,u);if(!Q&&(u>n||I>n-40||m))return this._getMainHeader(e,n*2);let p;if(I){const y=rt(A,I);p={basesCovered:j(y,0),scoreMin:y.getFloat64(8,!0),scoreMax:y.getFloat64(16,!0),scoreSum:y.getFloat64(24,!0),scoreSumSquares:y.getFloat64(32,!0)}}else throw new Error("no stats");let w="";if(u){const y=A.indexOf(0,u),N=y===-1?A.length:y;w=ts.decode(A.subarray(u,N))}return{zoomLevels:E,magic:o,extHeaderOffset:C,numZoomLevels:a,fieldCount:f,totalSummary:p,definedFieldCount:h,uncompressBufSize:d,asOffset:u,chromosomeTreeOffset:c,totalSummaryOffset:I,unzoomedDataOffset:l,unzoomedIndexOffset:g,fileType:B,version:i,autoSql:w}}async _readChromosomeTree(e,n){const A=[],s={},r=e.chromosomeTreeOffset,o=rt(await this.bbi.read(32,r,n)),i=o.getUint32(4,!0),a=o.getUint32(8,!0),c=o.getUint32(12,!0),l=4+i*(a+Math.max(c,8)),g=async f=>{const h=await this.bbi.read(l,f,n),u=rt(h),I=u.getUint8(0),d=u.getUint16(2,!0);let C=4;if(I)for(let E=0;E<d;E++){const B=uA(h,C,a);C+=a;const Q=u.getUint32(C,!0);C+=4;const m=u.getUint32(C,!0);C+=4,s[B]=Q,A[Q]={name:B,id:Q,length:m}}else{const E=[];for(let B=0;B<d;B++){C+=a;const Q=j(u,C);C+=8,E.push(g(Q))}await Promise.all(E)}};return await g(r+32),{refsByName:s,refsByNumber:A}}viewCache=new Map;getOrCreateBlockView(e,n,A,s){const r=`${n}_${s}`;let o=this.viewCache.get(r);return o||(o=new Jc(this.bbi,e,n,A,s),this.viewCache.set(r,o)),o}async getUnzoomedView(e){const{unzoomedIndexOffset:n,refsByName:A,uncompressBufSize:s,fileType:r}=await this.getHeader(e);return this.getOrCreateBlockView(A,n,s,r)}async _getView(e){const{basesPerSpan:n,scale:A}=e??{},s=n?1/n:A??1;return this.getView(s,e)}async getFeatures(e,n,A,s){return(await this._getView(s)).readWigData(e,n,A,s)}async getRegionByteSize(e,n,A,s){return(await this._getView(s)).getBlockSizeForRange(e,n,A,s)}async getRegionByteSizeMulti(e,n){return(await this._getView(n)).getBlockSizeForRangeMulti(e,n)}async getFeaturesMulti(e,n){return(await this._getView(n)).readWigDataMulti(e,n)}async getFeaturesAsArrays(e,n,A,s){return(await this._getView(s)).readWigDataAsArrays(e,n,A,s)}async getFeaturesAsArraysMulti(e,n){return(await this._getView(n)).readWigDataAsArraysMulti(e,n)}}class Go extends xo{async getView(e,n){const{zoomLevels:A,refsByName:s,uncompressBufSize:r}=await this.getHeader(n),o=1/e,i=A.length-1;for(let a=i;a>=0;a-=1){const c=A[a];if(c.reductionLevel<=2*o)return this.getOrCreateBlockView(s,c.indexOffset,r,"summary")}return this.getUnzoomedView(n)}}function Yc(t,e){if(e<0)return;let n=0;for(let s=0;s<e;s++){if(n=t.indexOf("	",n),n===-1)return;n++}const A=t.indexOf("	",n);return A===-1?t.slice(n):t.slice(n,A)}function Ks(t,e){return t<e?-1:t>e?1:0}async function Uo(t,e,n,A,s,r,o,i){const a=4+n*(A+s),c=await t.read(a,e,i),l=rt(c),g=l.getInt8(0),f=l.getInt16(2,!0);let h=4;if(g===0){const u=[];for(let B=0;B<f;B++){const Q=uA(c,h,A);h+=A;const m=j(l,h);h+=8,u.push({key:Q,offset:m})}let I=0,d=u.length-1,C=-1;for(;I<=d;){const B=Math.floor((I+d)/2);Ks(r,u[B].key)>=0?(C=B,I=B+1):d=B-1}const E=u[Math.max(C,0)].offset;return Uo(t,E,n,A,s,r,o,i)}else if(g===1){const u=[];for(let Q=0;Q<f;Q++){const m=uA(c,h,A);h+=A;const p=j(l,h);h+=8;const w=l.getUint32(h,!0);h+=4,h+=4,u.push({key:m,offset:p,length:w})}let I=0,d=u.length-1,C=-1;for(;I<=d;){const Q=Math.floor((I+d)/2),m=Ks(r,u[Q].key);if(m===0){C=Q;break}else m<0?d=Q-1:I=Q+1}if(C===-1)return[];let E=C;for(;E>0&&u[E-1].key===r;)E--;let B=C;for(;B<u.length-1&&u[B+1].key===r;)B++;return u.slice(E,B+1).map(Q=>({...Q,field:o}))}return[]}class vo extends xo{indicesP;readIndices(e={}){return this.indicesP||(this.indicesP=this._readIndices(e).catch(n=>{throw this.indicesP=void 0,n})),this.indicesP}async getView(e,n){return this.getUnzoomedView(n)}async _readIndices(e){const{extHeaderOffset:n}=await this.getHeader(e);if(n===0)return[];const A=await this.bbi.read(64,n,e),s=rt(A),r=s.getUint16(2,!0),o=j(s,4);if(r===0)return[];const i=20,a=i*r,c=await this.bbi.read(a,o,e),l=[];for(let g=0;g<r;g+=1){const f=rt(c,g*i),h=f.getInt16(0,!0),u=f.getInt16(2,!0),I=j(f,4),d=f.getInt16(16,!0);l.push({type:h,fieldcount:u,offset:I,field:d})}return l}async searchExtraIndexBlocks(e,n={}){const A=await this.readIndices(n);if(A.length===0)return[];const s=A.map(async o=>{const{offset:i,field:a}=o,c=await this.bbi.read(32,i,n),l=rt(c),g=l.getInt32(4,!0),f=l.getInt32(8,!0),h=l.getInt32(12,!0);return Uo(this.bbi,i+32,g,f,h,e,a,n)});return(await Promise.all(s)).flat()}async searchExtraIndex(e,n={}){const A=await this.searchExtraIndexBlocks(e,n);if(A.length===0)return[];const s=await this.getUnzoomedView(n),r=new Map;for(const i of A){const a=i.field??0,c=r.get(a);c?c.set(i.offset,i):r.set(a,new Map([[i.offset,i]]))}return(await Promise.all([...r].map(async([i,a])=>(await s.readFeatures([...a.values()],n)).map(l=>({...l,field:i}))))).flat().filter(i=>i.rest?Yc(i.rest,i.field-3)===e:!1)}}const Oc=["exact","case","decorated","prefix","padded","roman","organelle","accession","version"],qs=new Set(["gi","gb","ref","emb","dbj","tpg","tpe","tpd","lcl","pir","prf","sp","tr","pdb","ena","bbs"]);function es(t){let e=t.trim().split(/\s+/)[0]??"";if(e=e.replace(/[,;]+$/,""),e.includes("|")){const n=e.split("|").filter(A=>A!=="");if(n.some(A=>qs.has(A.toLowerCase()))){const A=n.filter((s,r)=>qs.has(s.toLowerCase())?!1:!(/^[0-9]+$/.test(s)&&r>0&&n[r-1].toLowerCase()==="gi"));A.length>0&&(e=A[A.length-1])}}return e}const To=/^(?:chromosome|chrom|chr)[ _.-]?/i;function Jo(t){const e=t.replace(To,"");if(e===""||e===t)return null;const n=e.toLowerCase();return/^[0-9]/.test(e)||Bn.has(n)||Qn.has(n)||Un(e)>0||/^un[_.-]/i.test(e)||/^[A-Za-z]{1,2}[0-9]/.test(e)||Yo.test(e)||Oo.test(e.replace(/\.[0-9]+$/,""))?e:null}const _c=/^(?:lg|linkage_?group|group)[ _.-]?(?=[0-9])/i,$o=/_(random|alt|fix|hap\d+|maternal|paternal)$/i,Kc=/(?:^|[_.-])([A-Z]{2}[0-9]{5,6})v([0-9]+)(?:$|[_.-])/,Yo=/^(N[CGTWZ]|AC)_([0-9]{5,})$/i,Oo=/^[A-Z]{1,6}[0-9]{5,8}$/,qc=[["mito",["m","mt","mtdna","mito","mitochondrion","mitochondria","mitochondrial","mitochondrion_genome","dmel_mitochondrion_genome","mitochondrial_genome","mitochondrion_dna","chrmt","nc_012920","j01415","nc_001224","nc_005089"]],["plastid",["c","pt","cp","chloroplast","plastid","chloroplast_genome","chrc","nc_000932"]],["2micron",["2-micron","2micron","2u","2-micron_plasmid","nc_001398"]]],Qn=new Map;for(const[t,e]of qc)for(const n of e)Qn.set(n,t);const Bn=new Set(["x","y","z","w"]),Hc=/^(XL|L|X{0,3})(IX|IV|V?I{0,3})$/i,Wc={"":0,x:10,xx:20,xxx:30,xl:40,l:50},Pc={"":0,i:1,ii:2,iii:3,iv:4,v:5,vi:6,vii:7,viii:8,ix:9};function Un(t){const e=Hc.exec(t);if(e===null)return 0;const n=Wc[e[1].toLowerCase()],A=Pc[e[2].toLowerCase()];return n===void 0||A===void 0?0:n+A}const zc=[{from:1,to:22,first:1,tail:["x","y"]},{from:67,to:85,first:1,tail:["x","y"]}];function Xc(t){for(const e of zc){if(t>=e.from&&t<=e.to)return String(e.first+(t-e.from));const n=t-e.to-1;if(n>=0&&n<e.tail.length)return e.tail[n]}return null}const IA=200;function Vc(t){return t.length<2||Bn.has(t.toLowerCase())?!1:Un(t)>0}function _o(t){const e=t.map(a=>Ko(a)),A=e.filter(a=>Vc(a)).length>=2,s=e.filter(a=>/^[0-9]+$/.test(a)&&Number(a)>=1&&Number(a)<=IA),r=s.length<IA,o=a=>e.some(c=>c.toLowerCase()===a),i=r&&s.length>=2;return{roman:A,ordinals:r,xIsTen:A&&!i&&(o("ix")||o("xi"))}}function Ko(t){const e=es(t);return(Jo(e)??e).replace($o,"")}function cn(t,e){const n=[],A=es(t);A!==t.trim()&&n.push("decorated");const s=Jo(A),r=s??A;s!==null&&n.push("prefix");const o=$o.exec(r),i=o===null?r:r.slice(0,o.index),a=o===null?"":`+${o[1].toLowerCase()}`,c=i.toLowerCase(),l=Kc.exec(r);if(l!==null)return n.push("accession"),{key:`acc:${l[1].toLowerCase()}`,via:n,version:l[2],opaque:!1};const g=/^(.*?)\.([0-9]+)$/.exec(i),f=g===null?i:g[1],h=g===null?null:g[2],u=Qn.get(c)??Qn.get(f.toLowerCase());if(u!==void 0)return u!==c&&n.push("organelle"),{key:`org:${u}`,via:n,version:h,opaque:!1};const I=Yo.exec(f);if(I!==null){n.push("accession");const E=I[1].toLowerCase()==="nc"?Xc(Number(I[2])):null;return E!==null?{key:Bn.has(E)?`sex:${E}${a}`:`num:${E}${a}`,via:n,version:h,opaque:!1}:{key:`acc:${f.toLowerCase()}${a}`,via:n,version:h,opaque:!1}}if(Oo.test(f))return n.push("accession"),{key:`acc:${f.toLowerCase()}${a}`,via:n,version:h,opaque:!1};if(/^[0-9]+$/.test(i)&&e.ordinals&&Number(i)<=IA)return/^0[0-9]/.test(i)&&n.push("padded"),{key:`num:${Number(i)}${a}`,via:n,version:null,opaque:!1};const d=/^([0-9]{1,2})([a-z]{1,2})$/i.exec(i);if(d!==null&&e.ordinals)return d[1].startsWith("0")&&n.push("padded"),{key:`num:${Number(d[1])}${d[2].toLowerCase()}${a}`,via:n,version:null,opaque:!1};const C=_c.exec(i);if(C!==null){const E=i.slice(C[0].length);if(/^[0-9]+$/.test(E))return/^0[0-9]/.test(E)&&n.push("padded"),{key:`lg:${Number(E)}${a}`,via:n,version:null,opaque:!1}}if(Bn.has(c)&&!(c==="x"&&e.xIsTen))return{key:`sex:${c}${a}`,via:n,version:null,opaque:!1};if(e.roman){const E=Un(i);if(E>0)return n.push("roman"),{key:`num:${E}${a}`,via:n,version:null,opaque:!1}}return{key:`raw:${c}${a}`,via:n,version:null,opaque:!0}}function Be(t){return Oc.indexOf(t)}function Zc(t,e){let n="case";for(const A of[...t.via,...e.via])Be(A)>Be(n)&&(n=A);return n}function Zn(t,e){return t===void 0||e===void 0||t<=0||e<=0?"unknown":t===e?"agree":"differ"}const Hs=new WeakMap;class St{names;context;styleCache=null;get style(){return this.styleCache??=tl(this.names,this.context),this.styleCache}exact=new Map;folded=new Map;keyed=new Map;constructor(e){this.names=e.map(n=>n.name),this.context=_o(this.names);for(const n of e){this.exact.has(n.name)||this.exact.set(n.name,n),Ws(this.folded,n.name.toLowerCase(),n);const A=cn(n.name,this.context);Ws(this.keyed,A.key,{sequence:n,canon:A})}}static of(e){return new St(e)}static ofNames(e){return new St(e.map(n=>({name:n})))}static for(e){const n=Hs.get(e);if(n!==void 0)return n;const A=typeof e[0]=="string"?St.ofNames(e):St.of(e);return Hs.set(e,A),A}has(e){return this.exact.has(e)}find(e,n={}){const{length:A}=n,s=this.exact.get(e);if(s!==void 0)return{name:s.name,asked:e,tier:"exact",lengths:Zn(A,s.length)};const r=this.folded.get(e.toLowerCase());if(r!==void 0&&r.length===1)return{name:r[0].name,asked:e,tier:"case",lengths:Zn(A,r[0].length)};const o=n.from??this.context,i=this.byKey(e,cn(e,o),A);if(i!==null)return i;if(!o.roman){const a=Ko(e).toLowerCase();if(a!=="x"&&a!=="l"&&Un(a)>0)return this.byKey(e,cn(e,{...o,roman:!0,xIsTen:!1}),A)}return null}byKey(e,n,A){const s=this.keyed.get(n.key);if(s===void 0||s.length===0)return null;const r=jc(s,A);if(r===null)return null;const o=Zc(n,r.canon),i=n.version!==null&&r.canon.version!==null&&n.version!==r.canon.version;return{name:r.sequence.name,asked:e,tier:i&&Be(o)<Be("version")?"version":o,lengths:Zn(A,r.sequence.length)}}}function jc(t,e){if(t.length===1)return t[0];if(e===void 0||e<=0)return null;const n=t.filter(A=>A.sequence.length===e);return n.length===1?n[0]:null}function Ws(t,e,n){const A=t.get(e);A===void 0?t.set(e,[n]):A.push(n)}function tl(t,e=_o(t)){if(t.length===0)return"empty";let n=0,A=0,s=0,r=0;for(const i of t){const a=cn(i,e);if(a.opaque){r++;continue}a.via.includes("accession")?s++:To.test(es(i))?n++:A++}const o=n+A+s;return o===0||r>o*4?"assembly":e.roman&&n<=A?"roman":s>n&&s>A?"accession":n>0&&A>0?"mixed":n>0?e.roman?"roman":"ucsc":e.roman?"roman":"ensembl"}function el(t,e){const n=St.of(e),A=St.of(t).context,s=[];for(const g of t){const f=n.find(g.name,{length:g.length,from:A});f!==null&&s.push({source:g,match:f})}s.sort((g,f)=>Be(g.match.tier)-Be(f.match.tier));const r=new Map,o=new Set;for(const g of s){const f=r.get(g.match.name);f===void 0?r.set(g.match.name,{source:g.source.name,tier:g.match.tier}):f.tier===g.match.tier&&o.add(g.match.name)}const i=new Map,a=[];let c=0;for(const g of s){const f=r.get(g.match.name);f===void 0||f.source!==g.source.name||o.has(g.match.name)||(i.set(g.source.name,g.match),g.match.tier!=="exact"&&c++,g.match.lengths==="differ"&&a.push(g.match))}const l=t.map(g=>g.name).filter(g=>!i.has(g));return{pairs:i,unmatched:l,contested:a,renamed:c}}function we(t,e){const n=el(t,e),A=new Map,s=t.map(r=>{const o=n.pairs.get(r.name);return o===void 0?r.name:(A.set(o.name,r.name),o.name)});for(const r of t)A.has(r.name)||A.set(r.name,r.name);return{names:s,sourceOf:A,renamed:n.renamed,contested:n.contested}}function nl(t){return t.map(e=>({name:e}))}function Kt(t,e){const n=Al(t),A=n.get(e);if(A!==void 0)return A;const s=St.for(t).find(e);return s===null?-1:n.get(s.name)??-1}const Ps=new WeakMap;function Al(t){const e=Ps.get(t);if(e!==void 0)return e;const n=new Map;return t.forEach((A,s)=>{const r=typeof A=="string"?A:A.name;n.has(r)||n.set(r,s)}),Ps.set(t,n),n}class Rt extends Error{code;detail;constructor(e,n,A={}){super(n),this.name="ViewerError",this.code=e,this.detail=A}}const jn=new Intl.NumberFormat(void 0,{maximumFractionDigits:0}),sl=new Intl.NumberFormat(void 0,{maximumFractionDigits:3}),rl=new Intl.NumberFormat(void 0,{maximumSignificantDigits:3}),zs=new Map,ol=new Intl.NumberFormat("en-US",{maximumFractionDigits:0}),G={int(t){return Number.isFinite(t)?jn.format(t):"—"},num(t){if(!Number.isFinite(t))return"—";if(Number.isInteger(t))return jn.format(t);const e=Math.abs(t);return e>=.001?sl.format(t):e>=1e-7?rl.format(t):t.toExponential(2)},fixed(t,e){if(!Number.isFinite(t))return"—";let n=zs.get(e);return n===void 0&&(n=new Intl.NumberFormat(void 0,{minimumFractionDigits:e,maximumFractionDigits:e}),zs.set(e,n)),n.format(t)},pct(t,e=1){return Number.isFinite(t)?`${(t*100).toFixed(e)}%`:"—"},pos(t){return Number.isFinite(t)?ol.format(Math.round(t)):"—"},bp(t){return Number.isFinite(t)?Math.abs(t)>=1e6?`${(t/1e6).toFixed(2)} Mb`:Math.abs(t)>=1e3?`${(t/1e3).toFixed(1)} kb`:`${jn.format(t)} bp`:"—"},bytes(t){if(!Number.isFinite(t))return"—";const e=["B","kB","MB","GB","TB"];let n=t,A=0;for(;n>=1e3&&A<e.length-1;)n/=1e3,A++;return`${A===0?n:n.toFixed(1)} ${e[A]}`}};function il(t){return!Number.isFinite(t)||t<=0?"—":t>=1e6?`${tA(t/1e6)} Mb`:t>=1e3?`${tA(t/1e3)} kb`:`${tA(t)} bp`}function tA(t){return String(Number(t.toFixed(2)))}function nt(t,e){const n=cl(t),A=ll(n,e);if(A===null)return n;throw new Rt("format",`The ${e.field} of this ${e.format} reads ${CA(t)}, ${A.reason}. `+Ie,{format:e.format,field:e.field,value:typeof t=="bigint"?t.toString():t,ceiling:e.ceiling,...e.available===void 0?{}:{available:e.available},...A.most===void 0?{}:{most:A.most}})}function ns(t,e,n){const A={format:n.format,field:n.field,offset:t,length:e,size:n.size};if(!dA(t)||!dA(e))throw new Rt("format",`The 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+`,g);N<0&&(N=f);let k=N;k>g&&t.charCodeAt(k-1)===13&&k--;const b=t.slice(g,k);if(g=N+1,b.startsWith(`${or} `)){const x=b.slice(or.length+1).trim().split(/\s+/),[Y,...J]=x;if(Y==="PLACEMENT")s=Number(J[0]);else if(Y==="FRAME"&&J.length===4){const[K,V,H,ht]=J.map(Number);[K,V,H].every(Number.isFinite)&&ht>0&&(r={cx:K,cy:V,cz:H,factor:ht})}else if(Y==="WIDTH"){const K=Number(J[0]);Number.isInteger(K)&&K>0&&(o=K)}else if(Y==="HAPLOTYPES")i=J.map(nA);else if(Y==="CHAIN"&&J.length>=6){const K=Number(J[2]),V=Number(J[3]);tn(K)&&tn(V)&&K<=V&&n.push({first:K,last:V,hap:nA(J[4]),sequence:nA(J.slice(5).join(" "))})}else if(Y==="RUN"&&J.length===4){const[K,V,H,ht]=J.map(Number);tn(K)&&Number.isInteger(V)&&V>0&&K+V-1<=ge&&Number.isInteger(H)&&H>=0&&Number.isInteger(ht)&&ht>0&&A.push({first:K,count:V,start:H,width:ht})}continue}if(l)continue;if(b.startsWith("ENDMDL")){l=!0;continue}if(!b.startsWith("HETATM")&&!b.startsWith("ATOM  "))continue;const D=Number(b.slice(6,11)),F=Number(b.slice(30,38)),R=Number(b.slice(38,46)),v=Number(b.slice(46,54));!tn(D)||!qg(F,R,v)||(b.slice(17,20)===Kg&&c++,a.push({serial:D,x:F,y:R,z:v}))}const h=e===""?"This file":e;if(a.length===0)throw new Error(`${h} has no ATOM or HETATM record with a place, so there is no bead to read.`);if(s===null||n.length===0||A.length===0)throw new Error(c===a.length?"These beads are named the way this app writes a PDB, but the lines that said where each one is on the genome are gone: PyMOL drops REMARK records when it saves. Open the PDB as this app wrote it, or its bed3d.":"A PDB says where each bead is in space and not where it is on the genome, and this one does not say: pastis and the other solvers write their beads in bin order and nothing else. Write the coordinates beside the bins they were modelled at, as a bed3d (chrom, start, end, x, y, z), and open that.");if(s!==ir)throw new Error(`This PDB's placement table is version ${String(s)}, and this reader understands version ${ir}.`);const u=new Int32Array(ge+1).fill(-1);n.forEach((N,k)=>{for(let b=N.first;b<=N.last;b++)u[b]=k});const I=new Float64Array(ge+1).fill(-1),d=new Float64Array(ge+1);for(const N of A)for(let k=0;k<N.count;k++)I[N.first+k]=N.start+k*N.width,d[N.first+k]=N.width;const C=i??[],E=new Map;C.forEach((N,k)=>E.set(N,k));const B=r??{cx:0,cy:0,cz:0,factor:1},Q=new Uint8Array(ge+1),m=[];for(const N of a){const k=u[N.serial],b=I[N.serial];if(k<0||b<0||Q[N.serial]===1)continue;Q[N.serial]=1;const D=n[k];E.has(D.hap)||(E.set(D.hap,C.length),C.push(D.hap)),m.push({contig:D.sequence,start:b,end:b+d[N.serial],xyz:[N.x/B.factor+B.cx,N.y/B.factor+B.cy,N.z/B.factor+B.cz],hap:D.hap})}if(m.length===0)throw new Error(`${h} has a placement table, and it places none of the file's ${G.int(a.length)} atoms.`);const p=C.length>1,w=new et;for(const N of m)w.add(N.contig,N.start,N.end,{xyz:N.xyz,hap:E.get(N.hap)??0,detail:p?`${gs} ${N.hap}`:""});const y={width:o??Hg(m.map(N=>N.end-N.start)),haplotypes:C};return w.finish(null,y)}function tn(t){return Number.isInteger(t)&&t>=1&&t<=ge}function nA(t){try{return decodeURIComponent(t)}catch{return t}}function Hg(t){const e=new Map;for(const s of t)s>0&&e.set(s,(e.get(s)??0)+1);let n=0,A=1;for(const[s,r]of e)(r>n||r===n&&s<A)&&(n=r,A=s);return A}const AA="MessagePack value",ar=64,Wg=BigInt(Number.MAX_SAFE_INTEGER),Pg=BigInt(Number.MIN_SAFE_INTEGER);function mi(t,e=0){const n=new zg(t,e);return{value:n.next(),end:n.at}}class zg{constructor(e,n){this.bytes=e,this.at=n,this.view=new DataView(e.buffer,e.byteOffset,e.byteLength)}at;view;decoder=new TextDecoder;depth=0;next(){const e=this.u8();if(e<=127)return e;if(e>=224)return e-256;if(e>=128&&e<=143)return this.map(e&15);if(e>=144&&e<=159)return this.array(e&15);if(e>=160&&e<=191)return this.str(e&31);switch(e){case 192:return null;case 194:return!1;case 195:return!0;case 196:return this.bin(this.u8());case 197:return this.bin(this.u16());case 198:return this.bin(this.u32());case 202:return this.f32();case 203:return this.f64();case 204:return this.u8();case 205:return this.u16();case 206:return this.u32();case 207:return this.big(this.view.getBigUint64(this.take(8)));case 208:return this.i8();case 209:return this.i16();case 210:return this.i32();case 211:return this.big(this.view.getBigInt64(this.take(8)));case 217:return this.str(this.u8());case 218:return this.str(this.u16());case 219:return this.str(this.u32());case 220:return this.array(this.u16());case 221:return this.array(this.u32());case 222:return this.map(this.u16());case 223:return this.map(this.u32());default:throw new Error(`msgpack: unsupported type byte 0x${e.toString(16).padStart(2,"0")} at offset ${this.at-1}.`)}}take(e){const n=this.at;if(n+e>this.bytes.length)throw new Error(`msgpack: truncated: needed ${e} byte${e===1?"":"s"} at offset ${n} of ${this.bytes.length}.`);return this.at=n+e,n}u8(){return this.view.getUint8(this.take(1))}u16(){return this.view.getUint16(this.take(2))}u32(){return this.view.getUint32(this.take(4))}i8(){return this.view.getInt8(this.take(1))}i16(){return this.view.getInt16(this.take(2))}i32(){return this.view.getInt32(this.take(4))}f32(){return this.view.getFloat32(this.take(4))}f64(){return this.view.getFloat64(this.take(8))}big(e){if(e>Wg||e<Pg)throw new Error(`msgpack: the 64-bit integer ${e} at offset ${this.at-9} does not fit a JavaScript number.`);return Number(e)}str(e){const n=this.take(e);return this.decoder.decode(this.bytes.subarray(n,n+e))}bin(e){const n=this.take(e);return this.bytes.subarray(n,n+e)}open(e,n,A){if(this.depth>=ar)throw new Rt("format",`This ${AA} nests deeper than ${ar} levels at offset ${this.at}, which no document this reader opens does. The file is corrupt, or not the format its first bytes claim.`,{format:AA,offset:this.at,depth:this.depth});return this.depth++,nt(e,{format:AA,field:`${n} length at offset ${this.at}`,ceiling:2**32-1,available:this.bytes.length-this.at,bytesPerItem:A})}array(e){const n=this.open(e,"array",1),A=new Array(n);for(let s=0;s<n;s++)A[s]=this.next();return this.depth--,A}map(e){const n=this.open(e,"map",2),A=new Map;for(let s=0;s<n;s++){const r=this.at,o=this.next();if(typeof o!="string"&&typeof o!="number")throw new Error(`msgpack: a map key at offset ${r} is neither a string nor an integer.`);A.set(o,this.next())}return this.depth--,A}}const cr=64e3,wn="binary g3d",wi={ratio:64,floor:64<<20,ceiling:1<<30},Xg=[165,109,97,103,105,99],Vg=[163,71,51,68];function hs(t){if(t.length===0)return!1;const e=t[0];let n;if(e>=128&&e<=143)n=1;else if(e===222)n=3;else return!1;const A=[...Xg,...Vg];if(t.length<n+A.length)return!1;for(let s=0;s<A.length;s++)if(t[n+s]!==A[s])return!1;return!0}async function Zg(t,e){const n=e===void 0?cr:Math.min(cr,e),A=await t(n,0);if(!hs(A))throw new Error("Not a binary g3d: the file does not begin with the G3D magic.");const{value:s}=mi(A);if(!(s instanceof Map))throw new Error("Not a binary g3d: the header is not a map.");if(s.get("magic")!=="G3D")throw new Error('Not a binary g3d: the magic is not "G3D".');const r=s.get("version");if(r!==2)throw r===1?new Error("This is a version-1 g3d, written by a g3dtools older than 0.2. Run `g3dtools load` over the original text to rewrite it as a version-2 file, which is the layout this reader and the WashU browser both understand."):new Error(`Unsupported g3d version ${String(r)}: this reader understands version 2.`);const o=Le(s.get("resolutions"),"resolutions"),i=nf(s.get("categories"),"categories"),a=s.get("offsets");if(!(a instanceof Map))throw new Error("This g3d has no offsets map in its header.");const c=new Map;for(const[l,g]of a){const f=typeof l=="number"?l:Number(l);if(!Number.isInteger(f)||!(g instanceof Map))continue;const h=g.get("offset"),u=g.get("size");if(typeof h!="number"||typeof u!="number")continue;const I=`${f} bp block`;nt(h,{format:wn,field:`offset of the ${I}`,ceiling:Number.MAX_SAFE_INTEGER}),nt(u,{format:wn,field:`size of the ${I}`,ceiling:wi.ceiling}),c.set(f,{offset:h,size:u})}for(const l of o)if(!c.has(l))throw new Error(`This g3d lists a resolution of ${l} bp but has no block for it.`);return{version:r,genome:typeof s.get("genome")=="string"?s.get("genome"):"",name:typeof s.get("name")=="string"?s.get("name"):"",resolutions:o,categories:i,offsets:c,...e===void 0?{}:{fileSize:e}}}async function jg(t,e,n){const A=e.offsets.get(n);if(A===void 0)throw new Error(`This g3d has no model at ${n} bp; it has ${e.resolutions.join(", ")}.`);e.fileSize!==void 0&&ns(A.offset,A.size,{format:wn,field:`${n} bp block`,size:e.fileSize});const s=await t(A.size,A.offset);if(s.length!==A.size)throw new Error(`The ${n} bp block of this g3d is ${s.length} bytes where the header promised ${A.size}.`);const{value:r}=mi(await ef(s,n));if(!(r instanceof Map))throw new Error(`The ${n} bp block of this g3d is not a map.`);const o=[...e.categories],i=o.length>1,a=new et;for(const[l,g]of r){const f=String(l);let h=o.indexOf(f);h<0&&(h=o.length,o.push(f));const u=i?`${gs} ${f}`:"";if(g instanceof Map)for(const[I,d]of g){if(!(d instanceof Map))continue;const C=`${f}/${String(I)} at ${n} bp`,E=Le(d.get("start"),`start of ${C}`),B=Le(d.get("x"),`x of ${C}`),Q=Le(d.get("y"),`y of ${C}`),m=Le(d.get("z"),`z of ${C}`);if(B.length!==E.length||Q.length!==E.length||m.length!==E.length)throw new Error(`The columns of ${C} in this g3d are not the same length.`);const p=String(I);for(let w=0;w<E.length;w++)a.add(p,E[w],E[w]+n,{xyz:[B[w],Q[w],m[w]],hap:h,detail:u})}}const c={width:n,haplotypes:o};return a.finish(null,c)}function tf(t){const e=t.resolutions.length,n=t.categories.length;return["binary g3d",`${e} resolution${e===1?"":"s"}`,`${n} categor${n===1?"y":"ies"}`].join(ct)}async function ef(t,e){return As(t,{format:wn,field:`${e} bp block`,encoding:"deflate",maxBytes:al(t.byteLength,wi)})}function Le(t,e){if(!Array.isArray(t))throw new Error(`This g3d's ${e} is not an array.`);for(const n of t)if(typeof n!="number")throw new Error(`This g3d's ${e} holds a value that is not a number.`);return t}function nf(t,e){if(!Array.isArray(t))throw new Error(`This g3d's ${e} is not an array.`);for(const n of t)if(typeof n!="string")throw new Error(`This g3d's ${e} holds a value that is not a string.`);return t}const Af=[66,65,73,1],sf=[67,83,73,1],rf=14,of=5,af=37450,Qt="BAM index",cf=65536,lf=65536,gf=10,ff=63,fe=2**31-1;function lr(t,e){return t.length<e.length?!1:e.every((n,A)=>t[A]===n)}async function hf(t){const e=He(t)?await Ot(t):t,n=lr(e,sf)?If:lr(e,Af)?uf:null;if(n===null)throw new Error("This is not a BAM index: the magic bytes are neither BAI\\1 nor CSI\\1.");try{return n(e)}catch(A){throw A instanceof RangeError?new Rt("format",`This ${Qt} ends part-way through its own tables, ${e.byteLength.toLocaleString("en-US")} bytes in. It is truncated; rebuild it with \`samtools index\`.`,{bytes:e.byteLength}):A}}function uf(t){const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=o=>t.byteLength-o,A=nt(e.getInt32(4,!0),{format:Qt,field:"reference count",ceiling:fe,available:n(8),bytesPerItem:8});let s=8;const r=[];for(let o=0;o<A;o++){const i=new Map,a=nt(e.getInt32(s,!0),{format:Qt,field:`bin count of reference ${o}`,ceiling:cf,available:n(s+4)-4,bytesPerItem:8});s+=4;for(let g=0;g<a;g++){const f=e.getUint32(s,!0);s+=4;const h=nt(e.getInt32(s,!0),{format:Qt,field:`chunk count of bin ${f}`,ceiling:fe,available:n(s+4),bytesPerItem:16});s+=4;const u=[];for(let I=0;I<h;I++)u.push({begin:e.getBigUint64(s,!0),end:e.getBigUint64(s+8,!0)}),s+=16;f!==af&&i.set(f,u)}const c=nt(e.getInt32(s,!0),{format:Qt,field:`linear index size of reference ${o}`,ceiling:lf,available:n(s+4),bytesPerItem:8});s+=4;const l=new BigUint64Array(c);for(let g=0;g<c;g++)l[g]=e.getBigUint64(s,!0),s+=8;r.push({bins:i,linear:l,loffset:null})}return{format:"bai",minShift:rf,depth:of,refs:r}}function If(t){const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=c=>t.byteLength-c,A=nt(e.getInt32(8,!0),{format:Qt,field:"CSI depth",ceiling:gf}),s=nt(e.getInt32(4,!0),{format:Qt,field:"CSI min_shift",ceiling:ff-3*A});let o=16+nt(e.getInt32(12,!0),{format:Qt,field:"auxiliary data length",ceiling:fe,available:n(16)-4});const i=nt(e.getInt32(o,!0),{format:Qt,field:"reference count",ceiling:fe,available:n(o+4),bytesPerItem:4});o+=4;const a=[];for(let c=0;c<i;c++){const l=new Map,g=new Map,f=nt(e.getInt32(o,!0),{format:Qt,field:`bin count of reference ${c}`,ceiling:fe,available:n(o+4),bytesPerItem:16});o+=4;for(let h=0;h<f;h++){const u=e.getUint32(o,!0);o+=4,g.set(u,e.getBigUint64(o,!0)),o+=8;const I=nt(e.getInt32(o,!0),{format:Qt,field:`chunk count of bin ${u}`,ceiling:fe,available:n(o+4),bytesPerItem:16});o+=4;const d=[];for(let C=0;C<I;C++)d.push({begin:e.getBigUint64(o,!0),end:e.getBigUint64(o+8,!0)}),o+=16;l.set(u,d)}a.push({bins:l,linear:null,loffset:g})}return{format:"csi",minShift:s,depth:A,refs:a}}function Je(t,e){return Math.floor(t/2**e)}function df(t,e,n,A){const s=[],r=Math.max(e,n-1);let o=A.minShift+A.depth*3,i=0;for(let a=0;a<=A.depth;a++){const c=i+Je(e,o),l=i+Je(r,o);if(l-c+1>t.bins.size)for(const[g,f]of t.bins)g>=c&&g<=l&&s.push(f);else for(let g=c;g<=l;g++){const f=t.bins.get(g);f!==void 0&&s.push(f)}i+=1<<a*3,o-=3}return s}function Cf(t,e,n){if(t.linear!==null){const r=Je(e,n.minShift);return t.linear.length===0?0n:t.linear[Math.min(r,t.linear.length-1)]}if(t.loffset===null)return 0n;let A=n.minShift,s=0;for(let r=n.depth;r>=0;r--){s=pi(r);const o=t.loffset.get(s+Je(e,A));if(o!==void 0)return o;A+=3}return 0n}function pi(t){let e=0;for(let n=0;n<t;n++)e+=1<<n*3;return e}function Qf(t,e,n){let A=null,s=n.minShift;for(let r=n.depth;r>=0;r--){const o=pi(r),i=1<<r*3,a=Je(Math.max(0,e-1),s)+1;for(let c=0;c<8&&a+c<i;c++){const l=t.bins.get(o+a+c);if(l!==void 0)for(const g of l)(A===null||g.begin<A)&&(A=g.begin)}s+=3}return A??BigInt(Number.MAX_SAFE_INTEGER)<<16n}const Bf=1<<20;function Ef(t,e,n,A,s){const r=t.refs[e];if(r===void 0)return[];const o=Cf(r,Math.max(0,n),t),i=Qf(r,Math.max(1,A),t),a=[];for(const l of df(r,Math.max(0,n),Math.max(1,A),t))for(const g of l)g.end>o&&g.begin<i&&a.push(g);if(a.length===0)return[];a.sort((l,g)=>l.begin<g.begin?-1:l.begin>g.begin?1:0);const c=[];for(const l of a){const g=Number(l.begin>>16n),f=Number(l.begin&0xffffn),h=Number(l.end>>16n),u=Math.min(s,h+Et),I=c[c.length-1];I!==void 0&&g<=I.to+Bf?(I.to=Math.max(I.to,u),I.lastBlock=Math.max(I.lastBlock,h)):c.push({from:g,to:u,lastBlock:h,dataFrom:f})}return c}function yi(t){let e=0;for(const n of t)e+=n.to-n.from;return e}const mf=2*Et,wf=Et,gr=1<<20,pf=4*Et,yf=16384,Nf=1<<24,kf=1<<18,bf=1<<24,pn=18,Pt=[31,139,8,4],Ee=36;function jt(t,e){return t<0?Number.POSITIVE_INFINITY:t*2**32+e+1}class wA extends Error{constructor(e,n){super("The reads are not in coordinate order."),this.before=e,this.after=n,this.name="UnsortedError"}}function fr(t,e){return t.refId<0?"unplaced":`${e[t.refId]?.name??`reference ${t.refId}`}:${(t.pos+1).toLocaleString("en-US")}`}function Df(t,e){const n=e-1;return t>>14===n>>14?32767/7+(t>>14):t>>17===n>>17?4095/7+(t>>17):t>>20===n>>20?511/7+(t>>20):t>>23===n>>23?63/7+(t>>23):t>>26===n>>26?7/7+(t>>26):0}class us{constructor(e,n,A,s){this.handle=e,this.size=n,this.refs=A,this.progress=s,this.lineStart=[];let r=0;for(const o of A)this.lineStart.push(r),r+=Math.max(0,o.length);this.lineLength=r}probes=[];answers=new Map;probing=new Map;lastWalk=null;walking=new Map;bytesRead=0;first=null;lineStart;lineLength;static async open(e,n,A,s,r){const o=new us(e,n,A.refs,s);if(o.first=await o.firstRecord(A.recordsFrom),o.first!==null&&A.sortOrder!=="coordinate")for(const i of[.125,.375,.625,.875])r!==void 0&&await r(),await o.probeAt(Math.floor(n*i));return o}get bytes(){return this.bytesRead}get probeCount(){return this.probes.length}async spansFor(e,n,A,s,r){if(this.first===null||A<=n)return[];const o=await this.locate(e,Math.max(0,n-yf),s);if(o===null||o.key>=jt(e,A))return[];if(r!==void 0&&o.block+r<this.size){s!==void 0&&await s();const c=await this.probeAt(hr(o.block+r,o.block));if(c.key<jt(e,A)){const l=c.block;return[{from:o.block,to:Math.min(this.size,l+Et),lastBlock:l,dataFrom:o.within}]}}const i=await this.locate(e,A,s),a=i===null||i.tail===!0?this.size:i.block;return[{from:o.block,to:Math.min(this.size,a+Et),lastBlock:a,dataFrom:o.within}]}locate(e,n,A){if(this.first===null)return Promise.resolve(null);const s=jt(e,n);if(this.first.key>=s)return Promise.resolve(this.first);const r=this.answers.get(s);if(r!==void 0)return r;const o=this.search(e,n,A).then(i=>(i!==null&&i.tail!==!0&&this.remember(i,!0),i));return this.answers.set(s,o),o.catch(()=>this.answers.delete(s)),o}async search(e,n,A){if(this.first===null)return null;const s=jt(e,n);let r=this.first,o=null;for(const c of this.probes)if(c.key<s)r=c;else{o=c;break}let i=!0;for(;;){const c=o===null?this.size:o.block,l=c-r.block;if(l<=pf)break;A!==void 0&&await A();const g=i?this.guess(r,o,e,n):null,f=await this.probeAt(hr(g??Math.floor((r.block+c)/2),r.block));if(f.block>=c)break;f.key>=s?o=f:r=f,i=(o===null?this.size:o.block)-r.block<=l/2}const a=o===null||o.tail===!0?this.size:Math.min(this.size,o.block+Et);return this.walk(r,a,s)}lineOf(e,n){return(this.lineStart[e]??this.lineLength)+Math.max(0,n)}guess(e,n,A,s){const r=this.lineOf(A,s),o=this.lineOf(e.refId,e.pos),i=n===null||n.tail===!0||n.refId<0?this.lineLength:this.lineOf(n.refId,n.pos);if(i<=o)return null;const a=(r-o)/(i-o);if(!(a>0&&a<1))return null;const c=n===null?this.size:n.block,l=e.block+Math.floor(a*(c-e.block));return Math.min(Math.max(l,e.block+1),c-2*Et)}async walk(e,n,A){if(n<=e.block)return null;let s=this.lastWalk;if(s===null||e.block<s.from||n>s.to){const c=`${e.block}-${n}`;let l=this.walking.get(c);if(l===void 0){l=this.read(n-e.block,e.block).then(async f=>{const{bytes:h,blocks:u}=await pA(f,e.block);return{from:e.block,to:n,bytes:h,blocks:u}}),this.walking.set(c,l);const g=()=>{this.walking.delete(c)};l.then(g,g)}s=await l,this.lastWalk=s}const{bytes:r,blocks:o}=s,i=o.find(c=>c.fileAt===e.block);if(i===void 0)return this.lastWalk=null,this.walk(e,n,A);let a=null;return En(r,i.from+e.within,c=>jt(c.refId,c.pos)<A?!0:(a=yA(o,c.at-4,c.refId,c.pos),!1)),a}probeAt(e){const n=this.probing.get(e);if(n!==void 0)return n;const A=this.probe(e);this.probing.set(e,A);const s=()=>{this.probing.delete(e)};return A.then(s,s),A}async probe(e){let n=mf;for(;;){const A=Math.min(this.size,e+n);if(A<=e)return this.remember({block:e,within:0,refId:-1,pos:-1,key:Number.POSITIVE_INFINITY,tail:!0});const s=await this.read(A-e,e),r=await Ff(s,e,this.refs,this.size);if(r.kind==="record")return this.remember(r.placed);if(r.kind==="end"||A>=this.size)return this.remember({block:e,within:0,refId:-1,pos:-1,key:Number.POSITIVE_INFINITY,tail:!0});if(n>=gr)throw new Error(`no alignment record could be made out within ${gr>>20} MB of byte ${e.toLocaleString("en-US")}`);n*=4}}remember(e,n=!1){let A=this.probes.length;for(;A>0&&this.probes[A-1].block>e.block;)A--;const s=this.probes[A-1];if(s!==void 0&&s.block===e.block&&s.within===e.within)return s;if(n)return this.probes.splice(A,0,e),e;const r=A===0?this.first:this.probes[A-1],o=A<this.probes.length?this.probes[A]:null;if(r!==null&&r.key>e.key)throw new wA(r,e);if(o!==null&&e.key>o.key)throw new wA(e,o);return this.probes.splice(A,0,e),e}async firstRecord(e){let n=kf;for(;;){const A=await this.read(Math.min(n,this.size),0);let s=0,r=0;for(;s+pn<=A.length;){const o=pe(A.subarray(s,Math.min(s+64,A.length)));if(o===null||s+o>A.length)break;const i=Ni(A,s+o-4);if(e<r+i){const{bytes:a,blocks:c}=await pA(A.subarray(s),s),l=e-r;if(l+Ee>a.length){if(A.length>=this.size)return null;break}if(!NA(a,l,this.refs))throw new Error("the first alignment record is not where the header says it begins");const g=new DataView(a.buffer,a.byteOffset,a.byteLength);return yA(c,l,g.getInt32(l+4,!0),g.getInt32(l+8,!0))}r+=i,s+=o}if(A.length>=this.size)return null;if(n>=bf)throw new Error("the header does not end within the first 16 MB");n*=4}}async read(e,n){const A=await this.handle.read(e,n);return this.bytesRead+=A.length,this.progress!==void 0&&this.progress(this.bytesRead),A}}async function pA(t,e){const n=[],A=[];let s=0,r=0,o=!1;for(;r+pn<=t.length;){const c=pe(t.subarray(r,Math.min(r+64,t.length)));if(c===null||r+c>t.length)break;const l=await Ot(t.subarray(r,r+c),0);l.length===0&&(o=!0),A.push({fileAt:e+r,from:s,to:s+l.length}),n.push(l),s+=l.length,r+=c}const i=new Uint8Array(s);let a=0;for(const c of n)i.set(c,a),a+=c.length;return{bytes:i,blocks:A,sawEnd:o}}function yA(t,e,n,A){for(const r of 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d=0,C=0;En(t,e,p=>{if(d++,p.refId===n&&(p.flag&o.exclude)===0&&!(p.mapq<o.minMapq)&&!(p.pos<0||p.end<=A||p.pos>=s)){if(C++,Yf(t,p,(w,y)=>{const N=Math.max(w,A),k=Math.min(y,s);k<=N||dr(f,h,(N-A)/g,(k-A)/g,r)}),a!==void 0){let w=null;Jf(t,p,(y,N)=>{if(N<=A||y>=s)return;w??=$f(t,p);const k=`${y}:${N}:${w}`;a.set(k,(a.get(k)??0)+1)})}if(c!==void 0)for(const w of Xo(t,p)){if(w.pos<A||w.pos>=s)continue;const y=_l(w.prob,c.threshold);if(y<0)continue;let N=c.tally.get(w.code);N===void 0&&(N={calls:new Float64Array(r),modified:new Float64Array(r)},c.tally.set(w.code,N));const k=Math.min(r-1,Math.floor((w.pos-A)/g));N.calls[k]++,y===1&&N.modified[k]++}i===void 0||u===null||I===null||vf(t,p,i,w=>{w<A||w>=s||dr(u,I,(w-A)/g,(w+1-A)/g,r)},[A,s])}});let E=0,B=0;const Q=new Float32Array(r);for(let p=0;p<r;p++){E+=h[p];const w=E+f[p];Q[p]=w,w>B&&(B=w)}let m=null;if(u!==null&&I!==null){m=new Float32Array(r);let p=0;for(let 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r=Math.min(s-1,Math.max(0,Math.floor(n))),o=Math.min(s-1,Math.max(0,Math.ceil(A)-1));if(!(o<r)){if(r===o){t[r]+=Math.min(A,r+1)-Math.max(n,r);return}t[r]+=r+1-Math.max(n,r),t[o]+=Math.min(A,o+1)-o,o>r+1&&(e[r+1]+=1,e[o]-=1)}}function Jf(t,e,n){const A=We(t,e),s=A===null?e.cigarOps:A.length,r=A===null?new DataView(t.buffer,t.byteOffset,t.byteLength):null;let o=e.pos;for(let i=0;i<s;i++){const a=r===null?A[i]:r.getUint32(e.cigarAt+i*4,!0),c=a&15,l=a>>>4;if(c===3){l>0&&n(o,o+l),o+=l;continue}mt(c)&&(o+=l)}}function $f(t,e){let A=e.seqAt+(e.seqLength+1>>1)+e.seqLength;const s=e.at+e.bytes-4;for(;A+3<=s;){const r=t[A],o=t[A+1],i=String.fromCharCode(t[A+2]);if(A+=3,i==="A"&&(r===88&&o===83||r===116&&o===115)){const a=t[A]===43?1:t[A]===45?-1:0;return r===88?a:(e.flag&At.REVERSE)!==0?-a:a}if(A=rs(t,A,i,s),A<0)return 0}return 0}function Yf(t,e,n){const A=new DataView(t.buffer,t.byteOffset,t.byteLength),s=We(t,e),r=s===null?e.cigarOps:s.length,o=l=>s===null?A.getUint32(e.cigarAt+l*4,!0):s[l];let i=e.pos,a=e.pos,c=!1;for(let l=0;l<r;l++){const g=o(l),f=g&15,h=g>>>4;if(f===3){c&&i>a&&n(a,i),c=!1,i+=h,a=i;continue}mt(f)&&(c||(a=i,c=!0),i+=h)}c&&i>a&&n(a,i)}function Of(t,e,n){let A=2166136261;for(let s=e;s<n;s++)A^=t[s],A=Math.imul(A,16777619)>>>0;return A/4294967296}function _f(t,e,n,A,s,r,o){const i=new DataView(t.buffer,t.byteOffset,t.byteLength),a=o.filter;let c=0;const l=[];En(t,e,C=>{Cr(C,A,s,r,a)&&(c++,l.push(Of(t,C.at+32,C.at+32+C.nameBytes-1)))});const g=Math.max(1,Math.min(o.maxReads,o.maxRows*Kf)),f=c<=g?1:g/c,h=f<1,u=[],I=[];let d=0;return En(t,e,C=>{!Cr(C,A,s,r,a)||l[d++]>=f||I.push(qf(t,i,C,o,u))}),{pile:jf(I,n,A,s,r,o),total:c,kept:I.length,capped:h,rows:u.length,usedMd:I.some(C=>C.fromMd),usedCigar:I.some(C=>C.fromCigar)}}const Kf=8;function Cr(t,e,n,A,s){return t.refId!==e||(t.flag&s.exclude)!==0||t.mapq<s.minMapq?!1:t.pos>=0&&t.end>n&&t.pos<A}function qf(t,e,n,A,s){const r=We(t,n),o=r===null?n.cigarOps:r.length,i=h=>r===null?e.getUint32(n.cigarAt+h*4,!0):r[h],a=[];let c=0,l=0;for(let h=0;h<o;h++){const u=i(h);a.push(u);const I=u&15,d=u>>>4;I===4&&(h===0||h===1&&(i(0)&15)===5?c=d:(h===o-1||h===o-2&&(i(o-1)&15)===5)&&(l=d))}const g=Pf(t,n,a,A.reference),f=Wf(s,n.pos-c,n.end+l);return{refStart:n.pos,refEnd:n.end,clipStart:c,clipEnd:l,row:f,flag:n.flag,mapq:n.mapq,mateContig:n.nextRefId,matePos:n.nextPos,tlen:n.tlen,name:Ml(t,n),ops:a,diffPos:g.pos,diffBase:g.base,fromMd:g.fromMd,fromCigar:g.fromCigar,mods:A.colourBy==="basemod"?Xo(t,n,a):null}}const Hf=3;function Wf(t,e,n){for(let A=0;A<t.length;A++)if(t[A]+Hf<=e)return t[A]=n,A;return t.push(n),t.length-1}function bA(t,e,n){const A=t[e+(n>>1)],s=n%2===0?A>>4:A&15;return ye[os.charCodeAt(s)]}function Pf(t,e,n,A){const s={pos:[],base:[],fromMd:!1,fromCigar:!1};if(n.some(o=>(o&15)===8)){let o=e.pos,i=0;for(const a of n){const c=a&15,l=a>>>4;if(c===8){const g=Math.min(l,e.seqLength-i);for(let f=0;f<g;f++)s.pos.push(o+f),s.base.push(bA(t,e.seqAt,i+f))}mt(c)&&(o+=l),Yt(c)&&(i+=l)}return s.fromCigar=!0,s}const r=zf(t,e);if(r!==null)return Xf(t,e,n,r,s),s.fromMd=!0,s;if(A!==void 0){let o=e.pos,i=0;const a=A.start+A.bases.length;for(const c of n){const l=c&15,g=c>>>4;if(mt(l)&&Yt(l)){const f=Math.max(0,A.start-o),h=Math.min(g,a-o,e.seqLength-i);for(let u=f;u<h;u++){const I=o+u-A.start,d=ye[A.bases[I]],C=bA(t,e.seqAt,i+u);d!==C&&d<4&&C<4&&(s.pos.push(o+u),s.base.push(C))}}mt(l)&&(o+=g),Yt(l)&&(i+=g)}}return s}function zf(t,e){let A=e.seqAt+(e.seqLength+1>>1)+e.seqLength;const s=e.at+e.bytes-4;for(;A+3<=s;){const r=String.fromCharCode(t[A],t[A+1]),o=String.fromCharCode(t[A+2]);if(A+=3,r==="MD"&&o==="Z"){let i=A;for(;i<s&&t[i]!==0;)i++;return new TextDecoder().decode(t.subarray(A,i))}if(A=rs(t,A,o,s),A<0)return null}return null}function Xf(t,e,n,A,s){const r=[],o=[];let i=e.pos,a=0;for(const l of n){const g=l&15,f=l>>>4;if(mt(g)&&Yt(g)){const h=Math.min(f,e.seqLength-a);for(let u=0;u<h;u++)r.push(i+u),o.push(a+u)}mt(g)&&(i+=f),Yt(g)&&(a+=f)}let c=0;for(const l of A.match(/(\d+|\^[A-Za-z]+|[A-Za-z])/g)??[]){if(l.charCodeAt(0)===94)continue;const g=Number(l);if(Number.isFinite(g)&&l!==""){c+=g;continue}c<r.length&&(s.pos.push(r[c]),s.base.push(bA(t,e.seqAt,o[c]))),c+=1}}const bi=1e3;function Vf(t,e,n){switch(e){case"strand":return(t.flag&At.REVERSE)!==0?1:0;case"mapq":return t.mapq===0?0:t.mapq<30?1:2;case"pair":return(t.flag&At.PAIRED)===0?0:(t.flag&At.PROPER_PAIR)!==0?1:2;case"mate":return(t.flag&At.PAIRED)===0?0:(t.flag&At.MATE_UNMAPPED)!==0||t.mateContig<0?1:t.mateContig===n?2:3;case"insert":{const A=Math.abs(t.tlen);return(t.flag&At.PAIRED)===0||A===0?0:A>bi?2:1}default:return 0}}function Zf(t){switch(t){case"strand":return["forward","reverse"];case"mapq":return["MAPQ 0","MAPQ < 30","MAPQ ≥ 30"];case"pair":return["unpaired","proper pair","not a proper pair"];case"mate":return["unpaired","mate unmapped","same sequence","another sequence"];case"insert":return["unpaired","ordinary insert",`insert > ${bi}`];case"basemod":return["reads"];default:return["reads"]}}function jf(t,e,n,A,s,r){const o=t.length,i={contig:e,start:A,end:s,length:o,refStart:new Int32Array(o),refEnd:new Int32Array(o),clipStart:new Int32Array(o),clipEnd:new Int32Array(o),row:new Int16Array(o),flags:new Uint16Array(o),mapq:new Uint8Array(o),mateContig:new Int32Array(o),matePos:new Int32Array(o),tlen:new Int32Array(o),group:new Uint8Array(o),mate:new Int32Array(o).fill(-1),opAt:new Int32Array(o+1),opCode:new Uint8Array(t.reduce((l,g)=>l+g.ops.length,0)),opLen:new Int32Array(t.reduce((l,g)=>l+g.ops.length,0)),diffAt:new Int32Array(o+1),diffPos:new Int32Array(t.reduce((l,g)=>l+g.diffPos.length,0)),diffBase:new Uint8Array(t.reduce((l,g)=>l+g.diffPos.length,0)),contigs:[],groups:Zf(r.colourBy),names:[]};let a=0,c=0;for(let l=0;l<o;l++){const g=t[l];i.refStart[l]=g.refStart,i.refEnd[l]=g.refEnd,i.clipStart[l]=g.clipStart,i.clipEnd[l]=g.clipEnd,i.row[l]=g.row,i.flags[l]=g.flag,i.mapq[l]=g.mapq,i.mateContig[l]=g.mateContig,i.matePos[l]=g.matePos,i.tlen[l]=g.tlen,i.opAt[l]=a;for(const f of g.ops)i.opCode[a]=f&15,i.opLen[a]=f>>>4,a++;i.diffAt[l]=c;for(let f=0;f<g.diffPos.length;f++)i.diffPos[c]=g.diffPos[f],i.diffBase[c]=g.diffBase[f],c++;r.withNames&&i.names.push(g.name)}i.opAt[o]=a,i.diffAt[o]=c,r.colourBy==="basemod"&&(i.mods=th(t));for(let l=0;l<o;l++)i.group[l]=Vf(t[l],r.colourBy,n);return eh(i,n,e,r),nh(i,t),i}function th(t){const e=new Map;let n=0;for(const i of t)for(const a of i.mods??[]){const c=e.get(a.code)??[0,0];a.prob>=128&&c[0]++,c[1]++,e.set(a.code,c),n++}const A=[...e.entries()].sort((i,a)=>a[1][0]-i[1][0]||a[1][1]-i[1][1]||(i[0]<a[0]?-1:1)),s=new Map(A.map(([i],a)=>[i,a])),r={at:new Int32Array(t.length+1),pos:new Int32Array(n),code:new Uint8Array(n),prob:new Uint8Array(n),codes:A.map(([i])=>i),counts:A.map(([,[i]])=>i)};let o=0;for(let i=0;i<t.length;i++){r.at[i]=o;for(const a of t[i].mods??[])r.pos[o]=a.pos,r.code[o]=s.get(a.code)??0,r.prob[o]=a.prob,o++}return r.at[t.length]=o,r}function eh(t,e,n,A){const s=new Map;for(let r=0;r<t.length;r++){const o=t.mateContig[r];if(o<0){t.mateContig[r]=-1;continue}let i=s.get(o);i===void 0&&(i=t.contigs.length,t.contigs.push(o===e?n:A.refNameOf?.(o)??""),s.set(o,i)),t.mateContig[r]=i}}function nh(t,e){const n=new Map;for(let A=0;A<e.length;A++){const s=e[A].name;if(s===""||(t.flags[A]&At.SUPPLEMENTARY)!==0)continue;const r=n.get(s);if(r===void 0){n.set(s,A);continue}t.mate[r]===-1&&t.mate[A]===-1&&((t.flags[r]^t.flags[A])&(At.FIRST_IN_PAIR|At.SECOND_IN_PAIR))!==0&&(t.mate[r]=A,t.mate[A]=r)}}function Di(t){const e=t.split(`
+`,200);let n=0;for(const A of e){const s=A.trim();if(s==="")continue;if(/^(fixedStep|variableStep)\b/i.test(s))return"wig";if(/^track\b/i.test(s)){if(/type\s*=\s*"?bedGraph/i.test(s))return"bedgraph";if(/type\s*=\s*"?wiggle_0/i.test(s))return"wig";continue}if(s.startsWith("#")||/^browser\b/i.test(s))continue;const r=s.split(/\t| +/);if(r.length!==4||!S(r[1])||!S(r[2]))return null;const o=Number(r[3]);if(!Number.isFinite(o)||r[3].trim()==="")return null;if(n+=1,n>=4)return"bedgraph"}return n>0?"bedgraph":null}class Is{constructor(e){this.name=e}starts=[];ends=[];values=[];push(e,n,A){this.starts.push(e),this.ends.push(n),this.values.push(A)}get length(){return this.starts.length}finish(){const e=this.starts.length,n=Int32Array.from({length:e},(i,a)=>a);let A=!0;for(let i=1;i<e;i++)if(this.starts[i]<this.starts[i-1]){A=!1;break}A||n.sort((i,a)=>this.starts[i]-this.starts[a]);const s=new Int32Array(e),r=new Int32Array(e),o=new Float32Array(e);for(let i=0;i<e;i++){const a=n[i];s[i]=this.starts[a],r[i]=this.ends[a],o[i]=this.values[a]}return{name:this.name,starts:s,ends:r,values:o}}}function Mi(t){const e=new Map;let n=Number.POSITIVE_INFINITY,A=Number.NEGATIVE_INFINITY,s=0;for(const r of t.split(`
+`)){const o=r.trim();if(o===""||o.startsWith("#")||/^(track|browser)\b/i.test(o))continue;const i=o.split(/\t| +/);if(i.length<4)continue;const a=Number(i[1]),c=Number(i[2]),l=Number(i[3]);if(!Number.isInteger(a)||!Number.isInteger(c)||!Number.isFinite(l)||c<=a)continue;let g=e.get(i[0]);g===void 0&&(g=new Is(i[0]),e.set(i[0],g)),g.push(a,c,l),s+=1,l<n&&(n=l),l>A&&(A=l)}return ds(e,s,n,A)}function Fi(t){const e=new Map;let n=Number.POSITIVE_INFINITY,A=Number.NEGATIVE_INFINITY,s=0,r=null,o="",i=1,a=1,c=0,l=null;const g=(f,h)=>{l===null||!Number.isFinite(h)||(l.push(f,f+i,h),s+=1,h<n&&(n=h),h>A&&(A=h))};for(const f of t.split(`
+`)){const h=f.trim();if(h===""||h.startsWith("#")||/^(track|browser)\b/i.test(h))continue;const u=/^(fixedStep|variableStep)\s+(.*)$/i.exec(h);if(u!==null){r=u[1].toLowerCase()==="fixedstep"?"fixed":"variable";const I=new Map;for(const d of u[2].split(/\s+/)){const C=d.indexOf("=");C>0&&I.set(d.slice(0,C).toLowerCase(),d.slice(C+1))}if(o=I.get("chrom")??"",i=Number(I.get("span")??1)||1,a=Number(I.get("step")??1)||1,c=(Number(I.get("start")??1)||1)-1,o===""){l=null;continue}l=e.get(o)??new Is(o),e.set(o,l);continue}if(!(r===null||l===null))if(r==="fixed")g(c,Number(h)),c+=a;else{const I=h.split(/\t| +/);if(I.length<2)continue;const d=Number(I[0]);if(!Number.isInteger(d))continue;g(d-1,Number(I[1]))}}return ds(e,s,n,A)}function ds(t,e,n,A){const s=[];for(const r of t.values())r.length>0&&s.push(r.finish());return{contigs:s,length:e,min:Number.isFinite(n)?n:0,max:Number.isFinite(A)?A:0}}class Si{constructor(e){this.set=e;for(const n of e.contigs)this.byName.set(n.name,n)}byName=new Map;held(e){const n=this.byName.get(e);if(n!==void 0)return n;const A=Kt(this.set.contigs,e);return A<0?void 0:this.set.contigs[A]}get contigNames(){return this.set.contigs.map(e=>e.name)}get extent(){return{min:this.set.min,max:this.set.max}}get length(){return this.set.length}has(e){return this.held(e)!==void 0}samples(e,n,A,s){const r=this.held(e);if(r===void 0||A<=n)return null;const o=Ah(r.ends,n);let i=o;for(;i<r.starts.length&&r.starts[i]<A;)i+=1;if(i<=o)return{starts:new Int32Array(0),ends:new Int32Array(0),values:new Float32Array(0),min:null,max:null,summary:!1};const a=Math.max(1,s),c=Math.ceil((A-n)/a);if(i-o<=c)return{starts:r.starts.slice(o,i),ends:r.ends.slice(o,i),values:r.values.slice(o,i),min:null,max:null,summary:!1};const l=new Int32Array(c),g=new Int32Array(c),f=new Float32Array(c),h=new Float32Array(c),u=new Float32Array(c),I=new Float64Array(c),d=new Float64Array(c);h.fill(Number.NaN),u.fill(Number.NaN);for(let C=0;C<c;C++)l[C]=Math.round(n+C*a),g[C]=Math.round(Math.min(A,n+(C+1)*a));for(let C=o;C<i;C++){const E=Math.max(r.starts[C],n),B=Math.min(r.ends[C],A);if(B<=E)continue;const Q=r.values[C],m=Math.max(0,Math.floor((E-n)/a)),p=Math.min(c-1,Math.floor((B-1-n)/a));for(let w=m;w<=p;w++){const y=Math.min(B,g[w])-Math.max(E,l[w]);y<=0||(d[w]+=Q*y,I[w]+=y,(Number.isNaN(h[w])||Q<h[w])&&(h[w]=Q),(Number.isNaN(u[w])||Q>u[w])&&(u[w]=Q))}}for(let C=0;C<c;C++)f[C]=I[C]>0?d[C]/I[C]:Number.NaN;return{starts:l,ends:g,values:f,min:h,max:u,summary:!0}}}function Ah(t,e){let n=0,A=t.length;for(;n<A;){const s=n+A>>1;t[s]<=e?n=s+1:A=s}return n}const sh=1<<18,rh=64<<20;class Qr extends No{constructor(e,n,A=sh,s=rh){super(e,n),this.chunkBytes=A,this.budgetBytes=s}chunks=new Map;inflight=new Map;held=0;end=null;fetched=0;requests=0;async read(e,n,A){if(e<=0||this.end!==null&&n>=this.end)return new Uint8Array(0);const s=Math.floor(n/this.chunkBytes),r=Math.floor((n+e-1)/this.chunkBytes),o=[];let i=null;const 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C=Math.max(g.start,f.starts[I]),E=Math.min(g.end,f.ends[I]);E<=C||(h+=d*(E-C),u+=E-C)}s.push({contig:g.contig,start:g.start,end:g.end,name:n.name[o[l]]??"",signal:h,mean:u>0?h/u:Number.NaN})}}return s}function Uh(t,e){return{contig:t.contigs[t.contig[e]],start:t.start[e],end:t.end[e]}}function kn(t){return`${t.contig}:${t.start}-${t.end}`}function vh(t){return .5*Th(-t/Math.SQRT2)}function Th(t){const e=Math.abs(t),n=e<2?1-Jh(e):$h(e);return t>=0?n:2-n}function Jh(t){let e=t,n=t;for(let A=1;A<200&&(e*=2*t*t/(2*A+1),n+=e,!(e<Math.abs(n)*1e-17));A++);return 2/Math.sqrt(Math.PI)*Math.exp(-t*t)*n}function $h(t){let n=1/t,A=1e300,s=n;for(let r=1;r<300;r++){const o=r/2;n=t+o*n,n===0&&(n=1e-300),A=t+o/A,A===0&&(A=1e-300),n=1/n;const i=A*n;if(s*=i,Math.abs(i-1)<1e-16)break}return Math.exp(-t*t)/Math.sqrt(Math.PI)*s}function Yh(t){const e=t.length,n=new Float64Array(e).fill(Number.NaN),A=[];for(let o=0;o<e;o++)Number.isFinite(t[o])&&A.push(o);A.sort((o,i)=>t[i]-t[o]);const s=A.length;let r=Number.POSITIVE_INFINITY;for(let o=0;o<s;o++){const i=s/(s-o);r=Math.min(r,i*t[A[o]]),n[A[o]]=Math.min(1,r)}return n}function Ji(t){return t.rows[1]<=t.rows[0]&&t.cols[1]<=t.cols[0]}function Ae(t){let e=0;for(let s=0;s<t.length;s++)Number.isFinite(t[s])&&e++;const n=new Float64Array(e);let A=0;for(let s=0;s<t.length;s++)Number.isFinite(t[s])&&(n[A++]=t[s]);return n.sort()}function ve(t,e){const n=t.length;if(n===0)return Number.NaN;const A=Math.min(n-1,Math.max(0,e*(n-1))),s=Math.floor(A),r=Math.min(n-1,s+1);return t[s]+(t[r]-t[s])*(A-s)}function Oh(t){const e=Ae(t),n=e.length;if(n===0)return{n:0,mean:Number.NaN,sd:Number.NaN,median:Number.NaN,q1:Number.NaN,q3:Number.NaN};let A=0;for(let o=0;o<n;o++)A+=e[o];const s=A/n;let r=0;for(let o=0;o<n;o++)r+=(e[o]-s)**2;return{n,mean:s,sd:n>1?Math.sqrt(r/(n-1)):Number.NaN,median:ve(e,.5),q1:ve(e,.25),q3:ve(e,.75)}}function $i(t){const e=t.length,n=Array.from({length:e},(o,i)=>i).sort((o,i)=>t[o]-t[i]),A=new Float64Array(e);let s=0,r=0;for(;r<e;){let o=r;for(;o+1<e&&t[n[o+1]]===t[n[r]];)o++;const i=(r+o)/2+1;for(let c=r;c<=o;c++)A[n[c]]=i;const a=o-r+1;a>1&&(s+=a*a*a-a),r=o+1}return{ranks:A,ties:s}}function _h(t,e){const n=Ae(t),A=Ae(e),s=n.length,r=A.length;if(s===0||r===0)return{u:Number.NaN,z:Number.NaN,p:Number.NaN,effect:Number.NaN};const o=new Float64Array(s+r);o.set(n,0),o.set(A,s);const{ranks:i,ties:a}=$i(o);let c=0;for(let C=0;C<s;C++)c+=i[C];const l=c-s*(s+1)/2,g=s+r,f=s*r/2,h=s*r/12*(g+1-a/(g*(g-1))),u=2*l/(s*r)-1;if(!(h>0))return{u:l,z:0,p:1,effect:u};const I=l-f,d=(I-.5*Math.sign(I))/Math.sqrt(h);return{u:l,z:d,p:Math.min(1,2*vh(-Math.abs(d))),effect:u}}function Kh(t){const e=t.map(Ae).filter(g=>g.length>0),n=e.length,A=e.reduce((g,f)=>g+f.length,0);if(n<2||A<2)return{h:Number.NaN,df:Math.max(0,n-1),p:Number.NaN};const s=new Float64Array(A);let r=0;for(const g of e)s.set(g,r),r+=g.length;const{ranks:o,ties:i}=$i(s);let a=0;r=0;for(const g of e){let f=0;for(let h=0;h<g.length;h++)f+=o[r+h];a+=f*f/g.length,r+=g.length}a=12/(A*(A+1))*a-3*(A+1);const c=1-i/(A*A*A-A);if(!(c>0))return{h:Number.NaN,df:n-1,p:Number.NaN};const l=a/c;return{h:l,df:n-1,p:qh(l,n-1)}}function qh(t,e){return!(e>0)||Number.isNaN(t)?Number.NaN:t<=0?1:Hh(e/2,t/2)}function Hh(t,e){const n=Math.exp(-e+t*Math.log(e)-Yi(t));if(e<t+1){let a=1/t,c=a;for(let l=1;l<1e3&&(a*=e/(t+l),c+=a,!(Math.abs(a)<Math.abs(c)*1e-16));l++);return Math.max(0,1-c*n)}const A=1e-300;let s=e+1-t,r=1/A,o=1/s,i=o;for(let a=1;a<1e3;a++){const c=-a*(a-t);s+=2,o=c*o+s,Math.abs(o)<A&&(o=A),r=s+c/r,Math.abs(r)<A&&(r=A),o=1/o;const l=o*r;if(i*=l,Math.abs(l-1)<1e-16)break}return Math.min(1,n*i)}function Yi(t){if(t<.5)return Math.log(Math.PI/Math.sin(Math.PI*t))-Yi(1-t);const e=[.9999999999998099,676.5203681218851,-1259.1392167224028,771.3234287776531,-176.6150291621406,12.507343278686905,-.13857109526572012,9984369578019572e-21,15056327351493116e-23],n=t-1;let A=e[0];const s=n+7.5;for(let r=1;r<9;r++)A+=e[r]/(n+r);return .5*Math.log(2*Math.PI)+(n+.5)*Math.log(s)-s+Math.log(A)}const Wh=1e4,bn=["#0072b2","#d55e00","#009e73","#cc79a7","#e69f00","#56b4e9","#f0e442","#000000"],Ph="#999999",pr="rest of the genome",he=2e4,zh=async t=>{const e=Jn(t.params,"tracks");if(e.length===0)return t.note("No track was chosen. Load a bigWig, or run a task that makes one, and tick it under Tracks."),[];const n=[];for(const[u,I]of Object.entries(t.inputs.contigLengths??{}))I>0&&n.push({name:u,length:I});if(n.length===0)return t.note("This session knows no sequence lengths, so there is no genome to cut into stretches. Load a chrom.sizes, or the map itself."),[];const A=T(t.params,"resolution",0),s=A>0?Math.round(A):t.framing.binsize>0&&!Ji(t.framing)?t.framing.binsize:Wh;let r=st(t.params,"groupBy","features")==="track"?await Vh(t,n,s):Xh(t,n,s);if(r===null)return[];if(r=Zh(r,t),r.stretches.length===0)return t.note("No stretch of the genome fell in any group, so there is nothing to compare."),[];const o=u=>t.inputs.labels?.[u]??u,i=r.names.length,a=[],c=[],l=[];for(let u=0;u<e.length;u++){t.throwIfCancelled();const I=o(e[u]);t.progress(u,e.length,I);const d=await Es(t,e[u],r.stretches),C=r.names.map(()=>[]);for(let m=0;m<r.stretches.length;m++)Number.isFinite(d[m])&&C[r.stretches[m].group].push(d[m]);if(C.every(m=>m.length===0)){t.note(`${I} has no value over any stretch — its sequence names may not be the assembly's.`);continue}let E=0,B=0;for(const m of C){for(const p of m)B+=p;E+=m.length}for(let m=0;m<i;m++){const p=Oh(C[m]),w=E-p.n,y=w>0?(B-p.mean*p.n)/w:Number.NaN;let N=0;for(const k of r.stretches)k.group===m&&(N+=k.end-k.start);a.push({track:I,group:r.names[m],n:p.n,bases:N,mean:p.mean,sd:p.sd,median:p.median,q1:p.q1,q3:p.q3,vsRest:p.n>0?p.mean-y:Number.NaN})}const Q=C.map((m,p)=>({group:m,g:p})).filter(m=>m.group.length>0);if(Q.length>2){const m=Kh(Q.map(p=>p.group));c.push({track:I,test:"Kruskal–Wallis H",a:`all ${Q.length} groups`,b:"",statistic:m.h,effect:Number.NaN,difference:Number.NaN,p:m.p})}for(let m=0;m<Q.length;m++)for(let p=m+1;p<Q.length;p++){const w=Q[m],y=Q[p],N=_h(w.group,y.group);c.push({track:I,test:"Mann–Whitney U",a:r.names[w.g],b:r.names[y.g],statistic:N.u,effect:N.effect,difference:ve(Ae(w.group),.5)-ve(Ae(y.group),.5),p:N.p})}l.push({kind:"curve",id:`groupsignal-${u+1}`,label:`${I} by ${r.of}`,series:C.map((m,p)=>{const w=Au(m);return{name:r.names[p],x:Float64Array.from(w,(y,N)=>N),y:w,colour:r.colours[p],n:m.length,mark:"violin"}}),xLabel:r.of,yLabel:I,xScale:"linear",yScale:"linear"})}if(t.progress(e.length,e.length,"done"),l.length===0)return[];const g=Yh(c.map(u=>Number(u.p)));c.forEach((u,I)=>{u.q=g[I]});const f=l.some(u=>u.series.some(I=>(I.n??0)>he));t.note(`Compared over ${r.stretches.length.toLocaleString()} stretches of at most ${s.toLocaleString()} bp in ${i} groups, each the track's mean over the bases it has a value for.${f?` A violin of more than ${he.toLocaleString()} is drawn from that many, evenly by rank; the tests use every one.`:""}`);const h=[...l];if(h.push({kind:"table",id:"groupsignal-groups",label:`Groups · ${r.of}`,columns:[{key:"track",label:"Track",kind:"text"},{key:"group",label:"Group",kind:"text"},{key:"n",label:"Stretches",kind:"number"},{key:"bases",label:"Bases",kind:"number"},{key:"mean",label:"Mean",kind:"number",digits:4},{key:"sd",label:"SD",kind:"number",digits:4},{key:"median",label:"Median",kind:"number",digits:4},{key:"q1",label:"Q1",kind:"number",digits:4},{key:"q3",label:"Q3",kind:"number",digits:4},{key:"vsRest",label:"Mean − rest",kind:"number",digits:4,hint:"This group’s mean less that of every other stretch."}],rows:a}),h.push({kind:"table",id:"groupsignal-tests",label:"Between groups",columns:[{key:"track",label:"Track",kind:"text"},{key:"test",label:"Test",kind:"text"},{key:"a",label:"Group",kind:"text"},{key:"b",label:"Against",kind:"text"},{key:"difference",label:"Median difference",kind:"number",digits:4},{key:"effect",label:"Effect",kind:"number",digits:3,hint:"Rank-biserial r: +1 where every value of the group is above every value against it."},{key:"statistic",label:"U or H",kind:"number",digits:2},{key:"p",label:"P",kind:"number",digits:4,scientific:!0},{key:"q",label:"q",kind:"number",digits:4,scientific:!0,hint:"Benjamini–Hochberg, over every test of the run."}],rows:c}),r.segments!==void 0&&h.push({kind:"intervals",id:"groupsignal-segments",label:`Groups · ${r.of}`,payload:{kind:"features",data:r.segments},noun:{one:"segment",many:"segments"},display:"lane",look:"corner"}),st(t.params,"groupBy","features")!=="track"&&Lt(t.params,"perFeature",!1)){const u=await nu(t,e,o);u!==null&&h.push(u)}return h};function Xh(t,e,n){const A=ne(t.inputs.features,t.params,"features"),s={chosen:A.chosen,value:A.chosen?A.value:void 0},r=s.value;if(r===void 0)return t.note(Yn(s,{unchosen:"No feature set was chosen to make the groups from.",gone:"The feature set chosen is no longer loaded. Re-open the file, or pick another."})??""),null;const o=st(t.params,"split","name"),i=t.inputs.labels?.[at(t.params,"features")??""]??"the set",a=new Array(r.length).fill(null);let c;if(o==="score"){const Q=Oi(t),m=Ti(r.score,Q);if(m.length===0)return t.note(`${i} carries no scores, so it cannot be cut into quantiles of them.`),null;c=Array.from({length:Q},(p,w)=>_i(w,m));for(let p=0;p<r.length;p++){const w=Ki(r.score[p],m);w>=0&&(a[p]=c[w])}}else if(o==="strand"){c=["+ strand","− strand","no strand"];for(let Q=0;Q<r.length;Q++)a[Q]=r.strand[Q]>0?c[0]:r.strand[Q]<0?c[1]:c[2]}else if(o==="none")c=[i],a.fill(i);else{for(let Q=0;Q<r.length;Q++)a[Q]=r.name[Q]===""?"(no name)":r.name[Q];c=[...new Set(a.filter(Q=>Q!==null))].sort((Q,m)=>Q.localeCompare(m,void 0,{numeric:!0}))}const l=c.filter(Q=>a.includes(Q)),g=Lt(t.params,"outside",!0),f=g?[...l,pr]:l,h=new Map(f.map((Q,m)=>[Q,m])),u=Q=>e.find(m=>m.name===Q)?.length??t.lengthOf(Q),I=new Map,d=new Set;for(let Q=0;Q<r.contigs.length;Q++){const m=r.contigs[Q],p=u(m);if(p===void 0){r.contigAt[Q+1]>r.contigAt[Q]&&d.add(m);continue}const w=f.map(()=>[]);for(let y=r.contigAt[Q];y<r.contigAt[Q+1];y++){const N=a[y];if(N===null)continue;const k=Math.max(0,r.start[y]),b=Math.min(p,r.end[y]);b>k&&w[h.get(N)??0].push([k,b])}I.set(m,w.map(yr))}d.size>0&&t.note(`${[...d].slice(0,6).join(", ")}${d.size>6?", …":""} ${d.size===1?"is":"are"} not a sequence of this assembly, so ${d.size===1?"its":"their"} features were left out.`);const C=[],E=new Map;for(const[Q,m]of I)m.forEach((p,w)=>{for(const[y,N]of p)for(const[k,b]of sA(y,N,n))C.push({contig:Q,start:k,end:b,group:w})}),E.set(Q,yr(m.flat()));if(g){const Q=f.length-1;for(const{name:m,length:p}of e){let w=0;for(const[y,N]of E.get(m)??[]){for(const[k,b]of sA(w,y,n))C.push({contig:m,start:k,end:b,group:Q});w=Math.max(w,N)}for(const[y,N]of sA(w,p,n))C.push({contig:m,start:y,end:N,group:Q})}}const B=o==="score"?"score":o==="strand"?"strand":o==="none"?"":"name";return{names:f,colours:f.map((Q,m)=>Q===pr?Ph:bn[m%bn.length]),stretches:C,of:B===""?i:`${i}, by ${B}`}}async function Vh(t,e,n){const A=at(t.params,"groupTrack");if(A===null)return t.note("No track was chosen to group the bins by."),null;const s=t.inputs.labels?.[A]??A,r=[];for(const h of e)for(let u=0;u<h.length;u+=n)r.push({contig:h.name,start:u,end:Math.min(h.length,u+n),group:-1});const o=await Es(t,A,r),i=st(t.params,"cut","sign")==="quantiles"?"quantiles":"sign";let a;if(i==="sign"){a=["above 0","below 0"];for(let h=0;h<r.length;h++)r[h].group=o[h]>0?0:o[h]<0?1:-1}else{const h=Oi(t),u=Ti(o,h);if(u.length===0)return t.note(`${s} has no value over any bin, so there is nothing to cut into quantiles.`),null;a=Array.from({length:h},(I,d)=>_i(d,u));for(let I=0;I<r.length;I++)r[I].group=Ki(o[I],u)}const c=r.filter(h=>h.group>=0);c.length<r.length&&t.note(`${(r.length-c.length).toLocaleString()} of ${r.length.toLocaleString()} bins had no reading of ${s}${i==="sign"?", or read exactly 0,":""} and are in no group.`);const l=new et;let g=null;const f=()=>{g!==null&&l.add(g.contig,g.start,g.end,{name:a[g.group]}),g=null};for(const h of c){if(g!==null&&g.contig===h.contig&&g.group===h.group&&g.end===h.start){g.end=h.end;continue}f(),g={...h}}return f(),{names:a,colours:a.map((h,u)=>bn[u%bn.length]),stretches:c,of:`${s}, ${i==="sign"?"by sign":"in quantiles"}`,segments:l.finish()}}function Zh(t,e){const n=new Array(t.names.length).fill(0);for(const o of t.stretches)n[o.group]++;if(n.every(o=>o>0))return t;const A=t.names.filter((o,i)=>n[i]===0);e.note(`${A.join(", ")} had no stretch in ${A.length===1?"it":"them"}, and ${A.length===1?"is":"are"} left out.`);const s=t.names.map((o,i)=>i).filter(o=>n[o]>0),r=new Map(s.map((o,i)=>[o,i]));return{...t,names:s.map(o=>t.names[o]),colours:s.map(o=>t.colours[o]),stretches:t.stretches.map(o=>({...o,group:r.get(o.group)??0}))}}function 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Use A C G T U and the ambiguity codes R Y S W K M B D H V N.`};n[A]=s}return n}function Pi(t){const e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)e[n]=yu[t[t.length-1-n]??0]??0;return e}function Nu(t){const e=Pi(t);for(let n=0;n<t.length;n++)if(t[n]!==e[n])return!1;return!0}function Dr(t,e,n,A){let s=0;for(let r=0;r<e.length;r++){const o=Wi[t[n+r]??0]??0,i=e[r]??0;if((o===0||(o&~i)!==0)&&(s++,s>A))return s}return s}function ms(t,e,n={}){const A=[];if(e.length===0||t.length<e.length)return{hits:A,truncated:!1};const s=n.offset??0,r=n.limit??Number.POSITIVE_INFINITY,o=Math.max(0,Math.min(e.length-1,Math.floor(n.mismatches??0))),i=n.bothStrands===!0,a=i&&Nu(e),c=i&&!a?Pi(e):null,l=a?0:1,g=t.length-e.length;for(let f=0;f<=g;f++){const h=Dr(t,e,f,o);if(h<=o&&(A.push({start:f+s,end:f+e.length+s,strand:l,mismatches:h}),A.length>=r))return{hits:A,truncated:f<g};if(c!==null){const u=Dr(t,c,f,o);if(u<=o&&(A.push({start:f+s,end:f+e.length+s,strand:-1,mismatches:u}),A.length>=r))return{hits:A,truncated:f<g}}}return{hits:A,truncated:!1}}function ku(t){return Math.max(0,t.length-1)}function bu(t){return t>0?"+":t<0?"−":"±"}function Du(t,e){const n=new et,A=e.replace(/\s+/g,"").toUpperCase();for(const s of t.hits)for(let r=0;r<s.starts.length;r++){const o=s.strands[r],i=s.mismatches?.[r];n.add(s.contig,s.starts[r],s.ends[r],{strand:o,name:`${A} ${bu(o)}`,...i===void 0?{}:{score:i,detail:`${i} ${i===1?"mismatch":"mismatches"}`}})}return n.finish()}function zi(t,e,n){const A=[];let s=0;for(const i of e){const a=Math.max(1,Math.ceil(i.length/n));A.push({name:i.name,startBin:s,bins:a,length:i.length}),s+=a}const r=new Float32Array(s),o=new Map(A.map(i=>[i.name,i]));for(const i of t.hits){const a=o.get(i.contig);if(a!==void 0)for(let c=0;c<i.starts.length;c++){const l=Math.min(a.bins-1,Math.floor(i.starts[c]/n));r[a.startBin+l]+=1}}return{binsize:n,firstBin:0,values:r,contigs:A}}function Mu(t,e,n=0){const A=t.replace(/\s+/g,"").toUpperCase(),s=[...e?["both strands"]:[],...n>0?[`≤ ${n} ${n===1?"mismatch":"mismatches"}`]:[]];return s.length===0?A:`${A} (${s.join(", ")})`}const fn=5e5,Fu=16e6;function Su(t){const e=t.pattern;return typeof e=="string"?e.replace(/\s+/g,"").toUpperCase():""}async function Ru(t,e,n){const A=Math.max(1,Math.min(n.limit,fn)),s=n.mismatches??0,r=n.contigs??t.contigs,o=ku(e),i=t.read?.bind(t),a=Math.max(1,Math.floor(n.piece??Fu)),c=[];let l=0,g=!1;const f=r.reduce((u,I)=>u+I.length,0);let h=0;for(const u of r){if(l>=A){g=!0;break}const I=[];let d=!1;const C=(w,y)=>{const N=A-l-I.length,k=ms(w,e,{bothStrands:n.bothStrands,limit:N+1,mismatches:s,offset:y});for(let b=0;b<Math.min(k.hits.length,N);b++)I.push(k.hits[b]);(k.truncated||k.hits.length>N)&&(d=!0)};if(i===void 0){const w=t.bases(u.name);if(w===void 0)continue;C(w,0),h+=u.length,n.progress?.(h,f,u.name)}else for(let w=0;w<u.length&&!d;w+=a){n.throwIfCancelled?.();const y=Math.min(u.length,w+a),N=await i(u.name,w,Math.min(u.length,y+o));if(N===void 0)break;C(N,w),h+=y-w,n.progress?.(h,f,u.name)}d&&(g=!0);const E=I.length;if(E===0){if(d)break;continue}const B=new Int32Array(E),Q=new Int32Array(E),m=new Int8Array(E),p=s>0?new Uint8Array(E):void 0;for(let w=0;w<E;w++){const y=I[w];B[w]=y.start,Q[w]=y.end,m[w]=y.strand,p!==void 0&&(p[w]=y.mismatches)}if(c.push({contig:u.name,starts:B,ends:Q,strands:m,...p===void 0?{}:{mismatches:p}}),l+=E,d)break}return{hits:c,total:l,truncated:g}}function Xi(t,e,n){if(e===null)return[...t.contigs];const A=new Set(e);if(n.length>0&&n.every(r=>A.has(r)))return[...t.contigs];const s=new Set;for(const r of e){const o=Kt(t.contigs,r);o>=0&&s.add(o)}return t.contigs.filter((r,o)=>s.has(o))}const Lu=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to search."),[];if(e===null)return t.note("No reference was chosen. 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Bins were read from its start.`),c>1&&t.note(`Each bin was read over ${c} bins (${(c*r).toLocaleString()} bp) centred on it; the cumulative skew sums each bin’s own.`);const d=t.inputs.labels?.[e]??"reference",C=c>1?` · ${(c*r).toLocaleString()} bp window`:"";return A.map(B=>({kind:"profile",id:`composition-${B.toLowerCase()}`,label:`${Mr[B].name} · ${d}${B==="cumulative"?"":C}`,values:f[B],extent:[0,g],binsize:r,unit:Mr[B].unit}))},Oe=19,ta=50,Ku=2e6,qu=5e3,Hu=500,Wu=10;function Fr(t){const e=[0];for(const n of t)e.push(e[e.length-1]+n.length);return{names:t.map(n=>n.name),lengths:t.map(n=>n.length),offsets:e}}function Pu(t,e=Ku){return Math.max(1,Math.ceil(2*t/e-1))}const zu=(()=>{const t=new Int8Array(256).fill(-1);for(const[e,n]of[["A",0],["C",1],["G",2],["T",3]])t[e.charCodeAt(0)]=n,t[e.toLowerCase().charCodeAt(0)]=n;return t})();function Xu(t){const e=t>>>0,n=Math.floor(t/4294967296)>>>0;let A=Math.imul(e^Math.imul(n,2654435761),2246822507);return A^=A>>>13,A=Math.imul(A,3266489909),A^=A>>>16,A>>>0}class Vu{hash=new Uint32Array(1024);position=new Uint32Array(1024);strand=new Int8Array(1024);count=0;push(e,n,A){if(this.count===this.hash.length){const s=this.hash.length*2,r=new Uint32Array(s);r.set(this.hash),this.hash=r;const o=new Uint32Array(s);o.set(this.position),this.position=o;const i=new Int8Array(s);i.set(this.strand),this.strand=i}this.hash[this.count]=e,this.position[this.count]=n,this.strand[this.count]=A,this.count++}finish(){return{hash:this.hash.slice(0,this.count),position:this.position.slice(0,this.count),strand:this.strand.slice(0,this.count),count:this.count}}}function Sr(t,e,n,A=Oe){const s=new Vu,r=4**(A-1),o=new Float64Array(n+1),i=new Float64Array(n+1),a=new Int8Array(n+1);for(let c=0;c<t.names.length;c++){const l=e(t.names[c]);if(l===void 0)continue;const g=t.offsets[c];let f=0,h=0,u=0,I=0,d=0,C=-1,E=0;const B=o.length;for(let Q=0;Q<l.length;Q++){const m=zu[l[Q]];if(m<0){u=0,d=0,E=0;continue}if(f=f%r*4+m,h=Math.floor(h/4)+(3-m)*r,u++,u<A)continue;const p=Q-A+1;if(E++,f===h)continue;const w=f<h?1:-1,y=Xu(f<h?f:h);for(;d>0&&o[(I+d-1)%B]>=y;)d--;for(o[(I+d)%B]=y,i[(I+d)%B]=p,a[(I+d)%B]=w,d++;d>0&&i[I]<=p-n;)I=(I+1)%B,d--;if(E<n)continue;const N=i[I];N!==C&&(s.push(o[I],g+N,a[I]),C=N)}}return s.finish()}function Dn(t,e=t.length,n){let A=new Uint32Array(e);if(n===void 0)for(let o=0;o<e;o++)A[o]=o;else A.set(n.subarray(0,e));let s=new Uint32Array(e);const r=new Uint32Array(65537);for(const o of[0,16]){r.fill(0);for(let i=0;i<e;i++)r[(t[A[i]]>>>o&65535)+1]++;for(let i=0;i<65536;i++)r[i+1]+=r[i];for(let i=0;i<e;i++)s[r[t[A[i]]>>>o&65535]++]=A[i];[A,s]=[s,A]}return A}function Zu(t,e,n=ta){const A=Dn(t.hash,t.count),s=Dn(e.hash,e.count);let r=new Uint32Array(1024),o=new Uint32Array(1024),i=new Int8Array(1024),a=0,c=0,l=0,g=0;for(;l<t.count&&g<e.count;){const f=t.hash[A[l]],h=e.hash[s[g]];if(f<h){l++;continue}if(h<f){g++;continue}let u=l;for(;u<t.count&&t.hash[A[u]]===f;)u++;let I=g;for(;I<e.count&&e.hash[s[I]]===h;)I++;if(u-l>n||I-g>n)c++;else for(let d=l;d<u;d++)for(let C=g;C<I;C++){if(a===r.length){const E=r.length*2,B=new Uint32Array(E);B.set(r),r=B;const Q=new Uint32Array(E);Q.set(o),o=Q;const m=new Int8Array(E);m.set(i),i=m}r[a]=t.position[A[d]],o[a]=e.position[s[C]],i[a]=t.strand[A[d]]===e.strand[s[C]]?1:-1,a++}l=u,g=I}return{x:r.slice(0,a),y:o.slice(0,a),strand:i.slice(0,a),count:a,dropped:c}}function ju(t,e=qu,n=Hu,A=Wu,s){const r=[];s?.fill(-1);let o=0;for(let a=0;a<t.count;a++)t.y[a]>o&&(o=t.y[a]);for(const a of[1,-1]){let c=0;for(let B=0;B<t.count;B++)t.strand[B]===a&&c++;const l=new Uint32Array(c),g=new Uint32Array(c),f=new Uint32Array(c),h=Math.ceil(o/n)+1;for(let B=0,Q=0;B<t.count;B++)t.strand[B]===a&&(l[Q]=B,g[Q]=t.x[B],f[Q]=a===1?Math.round((t.x[B]-t.y[B])/n)+h:Math.round((t.x[B]+t.y[B])/n),Q++);const u=Dn(f,c,Dn(g,c)),I=new Uint32Array(c),d=new Uint32Array(c);for(let B=0;B<c;B++)I[B]=l[u[B]],d[B]=f[u[B]];let C=0;const E=B=>{const Q=B-C;if(Q>=A){let m=Number.POSITIVE_INFINITY,p=Number.NEGATIVE_INFINITY,w=Number.POSITIVE_INFINITY,y=Number.NEGATIVE_INFINITY;for(let N=C;N<B;N++){const k=I[N];m=Math.min(m,t.x[k]),p=Math.max(p,t.x[k]+Oe),w=Math.min(w,t.y[k]),y=Math.max(y,t.y[k]+Oe)}if(s!==void 0)for(let N=C;N<B;N++)s[I[N]]=r.length;r.push({x0:m,x1:p,y0:w,y1:y,strand:a,anchors:Q})}C=B};for(let B=1;B<=I.length;B++){if(B===I.length){E(B);break}const Q=I[B-1],m=I[B];(d[B-1]!==d[B]||t.x[m]-t.x[Q]>e)&&E(B)}}const i=r.map((a,c)=>c).sort((a,c)=>r[a].x0-r[c].x0||r[a].y0-r[c].y0);if(s!==void 0){const a=new Int32Array(r.length);i.forEach((c,l)=>a[c]=l);for(let c=0;c<t.count;c++)s[c]>=0&&(s[c]=a[s[c]])}return i.map(a=>r[a])}const tI=100,eI=4e5;function nI(t,e,n){const A=e.offsets[e.offsets.length-1],s=n.offsets[n.offsets.length-1],r=Math.max(tI,Math.ceil(Math.max(A,s)/eI)),o=new Uint8Array(Math.ceil(A/r)+1),i=new Uint8Array(Math.ceil(s/r)+1),a=(h,u)=>{const I=Math.floor(h/r);return[I,Math.max(I+1,Math.ceil(u/r))]},c=(h,u,I)=>{const[d,C]=a(u,I);let E=0;for(let B=d;B<C;B++)E+=h[B];return E/(C-d)},l=(h,u,I)=>{const[d,C]=a(u,I);h.fill(1,d,C)},g=new Uint8Array(t.length),f=t.map((h,u)=>u).sort((h,u)=>t[u].anchors-t[h].anchors||h-u);for(const h of f){const u=t[h];c(o,u.x0,u.x1)>.5||c(i,u.y0,u.y1)>.5||(g[h]=1,l(o,u.x0,u.x1),l(i,u.y0,u.y1))}return g}function AI(t,e,n,A,s){const r=e.offsets[e.offsets.length-1],o=n.offsets[n.offsets.length-1],i=Math.max(1,Math.ceil(Math.max(r,o)/Math.max(1,A))),a=Math.max(1,Math.ceil(r/i)),c=Math.max(1,Math.ceil(o/i)),l=new Float32Array(a*c);for(let g=0;g<t.count;g++){if(s!==void 0&&s[g]!==1)continue;const f=Math.min(a-1,Math.floor(t.x[g]/i)),h=Math.min(c-1,Math.floor(t.y[g]/i));l[h*a+f]+=t.strand[g]}return{values:l,ncols:a,nrows:c,cellSize:i}}function Rr(t,e){let n=0,A=t.names.length-1;for(;n<A;){const s=n+A+1>>1;t.offsets[s]<=e?n=s:A=s-1}return{sequence:n,at:e-t.offsets[n]}}const Lr=400;function sI(t,e,n,A,s){const r=t.length,o={x:{label:A,names:[...e.names],lengths:[...e.lengths]},y:{label:s,names:[...n.names],lengths:[...n.lengths]},x0:new Float64Array(r),x1:new Float64Array(r),y0:new Float64Array(r),y1:new Float64Array(r),strand:new Int8Array(r),anchors:new Int32Array(r)};return t.forEach((i,a)=>{o.x0[a]=i.x0,o.x1[a]=i.x1,o.y0[a]=i.y0,o.y1[a]=i.y1,o.strand[a]=i.strand,o.anchors[a]=i.anchors}),o}function xr(t,e){return t.names.map((n,A)=>({label:n,from:t.offsets[A]/e,to:t.offsets[A+1]/e}))}const rI=async t=>{const e=at(t.params,"x"),n=at(t.params,"y");if(t.residues===void 0)return t.note("This session cannot read residues, so there is nothing to set against anything."),[];if(e===null||n===null)return t.note("Choose the two sequence sets: one along x, one along y."),[];const A=t.residues(e),s=t.residues(n);if(A===void 0||s===void 0)return t.note("A sequence set chosen is no longer loaded. Drop the FASTA again, or pick another."),[];for(const R of[A,s])if(R.refusal!==void 0)return t.note(R.refusal),[];const r=Fr(A.contigs),o=Fr(s.contigs),i=r.offsets[r.offsets.length-1],a=Pu(i);t.progress(0,4,"minimizers along x");const c=Sr(r,R=>A.bases(R),a);t.throwIfCancelled(),t.progress(1,4,"minimizers along y");const l=Sr(o,R=>s.bases(R),a);t.throwIfCancelled(),t.progress(2,4,"anchors");const g=Zu(c,l);t.throwIfCancelled(),t.progress(3,4,"streaks");const f=new Int32Array(g.count),h=ju(g,void 0,void 0,void 0,f),u=e===n,I=!u&&st(t.params,"streaks","one to one")==="one to one",d=I?nI(h,r,o):new Uint8Array(h.length).fill(1),C=h.filter((R,v)=>d[v]===1),E=new Uint8Array(g.count);for(let R=0;R<g.count;R++)f[R]>=0&&d[f[R]]===1&&(E[R]=1);const B=Math.round(T(t.params,"cells",Lr)),Q=AI(g,r,o,B>0?B:Lr,E);t.progress(4,4);const m=c.count>0?Math.round(i/c.count):0,p=h.length-C.length;t.note(`Exact ${Oe}-mers, one in about ${m.toLocaleString("en-US")} bases; hashes above ${ta} copies on either side dropped (${g.dropped.toLocaleString("en-US")} of them). ${g.count.toLocaleString("en-US")} anchors, ${h.length.toLocaleString("en-US")} streaks`+(I?`, ${C.length.toLocaleString("en-US")} of them one to one — ${p.toLocaleString("en-US")} a stronger streak had taken the stretch of`:"")+(u?", every one drawn, the set against itself":"")+`. Not an alignment, and it writes none: a streak is ten or more shared ${Oe}-mers along one diagonal.`);const w=[];for(const R of Q.values)Math.abs(R)>=3&&w.push(Math.abs(R));w.sort((R,v)=>R-v);const y=w.length===0?3:Math.max(3,w[Math.floor(.5*(w.length-1))]),N={kind:"matrix",id:"dotplot-density",label:I?"Streaks one to one, the same way round (red) and the other (blue)":"Streaks, the same way round (red) and the other (blue)",nrows:Q.nrows,ncols:Q.ncols,values:Q.values,xLabel:"along x",yLabel:"along y",xTicks:[],yTicks:[],colormap:"RdBu_r",centre:0,range:[-y,y],xSegments:xr(r,Q.cellSize),ySegments:xr(o,Q.cellSize),stats:[{label:"anchors",value:g.count},{label:I?"streaks one to one":"streaks",value:C.length},{label:"bases a cell",value:Q.cellSize}],large:!0,streaks:sI(C,r,o,t.inputs.labels?.[e]??"along x",t.inputs.labels?.[n]??"along y")},k=C.map(R=>{const v=Rr(r,R.x0),x=Rr(o,R.y0);return{xSequence:r.names[v.sequence],xStart:v.at,xEnd:v.at+(R.x1-R.x0),ySequence:o.names[x.sequence],yStart:x.at,yEnd:x.at+(R.y1-R.y0),strand:R.strand===1?"+":"-",anchors:R.anchors}}),b={kind:"table",id:"dotplot-streaks",label:"Streaks",columns:[{key:"xSequence",label:"x sequence",kind:"text"},{key:"xStart",label:"x start",kind:"number",coordinate:"start"},{key:"xEnd",label:"x end",kind:"number",coordinate:"end"},{key:"ySequence",label:"y sequence",kind:"text"},{key:"yStart",label:"y start",kind:"number",coordinate:"start"},{key:"yEnd",label:"y end",kind:"number",coordinate:"end"},{key:"strand",label:"strand",kind:"text",hint:"+ the same way round, − the other"},{key:"anchors",label:"anchors",kind:"number"}],rows:k},D=new vn;for(const R of k)D.add(R.xSequence,R.xStart,R.xEnd,R.ySequence,R.yStart,R.yEnd,{score:R.anchors,name:R.strand==="+"?"same way round":"the other way round",detail:`${R.anchors} anchors`});const F={kind:"intervals",id:"dotplot-pairs",label:"Streaks, as pairs",payload:{kind:"pairs",data:D.finish()},noun:{one:"streak",many:"streaks"},display:"overlay"};return[N,b,F]};function RA(t,e,n,A){const s=Math.abs(t-e);return A&&n>0?Math.min(s,n-s%n):s}function oI(t,e,n){if(t.length===0)return Number.NaN;if(!n||!(e>0)){let i=0;for(const a of t)i+=a;return i/t.length}let A=0,s=0;for(const i of t){const a=2*Math.PI*i/e;A+=Math.sin(a),s+=Math.cos(a)}const o=(Math.atan2(A,s)/(2*Math.PI)*e%e+e)%e;return o>=e?0:o}function Gr(t,e,n,A){if(t.length===0)return null;let s=-1,r=0;for(let i=0;i<t.length;i++){let a=0;for(const c of t)RA(t[i],c,e,n)<=A&&a++;a>r&&(r=a,s=i)}const o=t.filter(i=>RA(t[s],i,e,n)<=A);return{centre:oI(o,e,n),count:o.length}}function iI(t,e,n){let A=-1,s=-1;for(let o=0;o<t.length;o++){const i=t[o];Number.isFinite(i)&&((A<0||i<t[A])&&(A=o),(s<0||i>t[s])&&(s=o))}const r=o=>o<0?Number.NaN:Math.min(n-1,Math.floor(o*e+e/2));return{low:r(A),high:r(s)}}const aI=10;function cI(t){const{length:e,circular:n,low:A,high:s}=t,r=e/8,o=Gr(t.matS,e,n,r),i=Gr(t.parS,e,n,r),a=t.minMatS??aI,c=(h,u)=>RA(h,u,e,n);let l=s,g="skew";if(o!==null&&t.matS.length>=a)l=c(A,o.centre)<c(s,o.centre)?A:s,g="matS";else if(i!==null)l=c(A,i.centre)>c(s,i.centre)?A:s,g="parS";else if(t.coverageAt!==void 0){const h=t.coverageAt(A),u=t.coverageAt(s);Number.isFinite(h)&&Number.isFinite(u)&&h!==u&&(l=h<u?A:s,g="coverage")}return{ori:l===s?A:s,ter:l,rule:g,agreesWithSkew:l===s,matS:o,parS:i}}function lI(t,e,n,A,s){const r=Math.max(s?3:1,Math.round(A)),o=s?r:r+3,i=n>0?r/n:0,a=B=>{let Q=B*i;s||(Q=Math.max(0,Math.min(r-1e-9,Q)));const m=Math.floor(Q),p=Q-m,w=[(1-p)**3/6,(3*p**3-6*p**2+4)/6,(-3*p**3+3*p**2+3*p+1)/6,p**3/6];return{first:s?m-1:m,w}},c=B=>s?(B%o+o)%o:B,l=new Float64Array(o*o),g=new Float64Array(o);let f=0;for(let B=0;B<t.length;B++){const Q=e[B];if(!Number.isFinite(Q))continue;f++;const{first:m,w:p}=a(t[B]);for(let w=0;w<4;w++){const y=c(m+w);g[y]+=p[w]*Q;for(let N=0;N<4;N++)l[y*o+c(m+N)]+=p[w]*p[N]}}let h=0,u=0;for(let B=0;B<e.length;B++)Number.isFinite(e[B])&&(h+=e[B],u++);h=u>0?h/u:0;const I=1e-6*Math.max(1,f/o);for(let B=0;B<o;B++)l[B*o+B]+=I,g[B]+=I*h;const d=gI(l,g,o),C=B=>{if(d===null)return Number.NaN;const{first:Q,w:m}=a(B);let p=0;for(let w=0;w<4;w++)p+=m[w]*d[c(Q+w)];return p},E=new Float64Array(t.length);for(let B=0;B<t.length;B++)E[B]=C(t[B]);return{fitted:E,at:C}}function gI(t,e,n){const A=Float64Array.from(t),s=Float64Array.from(e);for(let o=0;o<n;o++){let i=o;for(let a=o+1;a<n;a++)Math.abs(A[a*n+o])>Math.abs(A[i*n+o])&&(i=a);if(Math.abs(A[i*n+o])<1e-300)return null;if(i!==o){for(let c=0;c<n;c++){const l=A[o*n+c];A[o*n+c]=A[i*n+c],A[i*n+c]=l}const a=s[o];s[o]=s[i],s[i]=a}for(let a=o+1;a<n;a++){const c=A[a*n+o]/A[o*n+o];if(c!==0){for(let l=o;l<n;l++)A[a*n+l]-=c*A[o*n+l];s[a]-=c*s[o]}}}const r=new Float64Array(n);for(let o=n-1;o>=0;o--){let i=s[o];for(let a=o+1;a<n;a++)i-=A[o*n+a]*r[a];r[o]=i/A[o*n+o]}return r}function fI(t){let e=Number.NEGATIVE_INFINITY,n=Number.POSITIVE_INFINITY;for(const s of t)Number.isFinite(s)&&(s>e&&(e=s),s<n&&(n=s));return{ratio:n>0&&Number.isFinite(e)?e/n:Number.NaN,highest:e,lowest:n}}const hI="TGTTNCACGTGNAACA",uI="GTGACRNYGTCAC";function II(t,e){const n=t[e];return n==null?e==="parS"?hI:uI:typeof n=="string"?n.replace(/\s+/g,"").toUpperCase():""}const dI=5e3,oA={matS:"nearest the matS cluster",parS:"farthest from the parS cluster",coverage:"lower coverage",skew:"skew maximum"};function Ur(t,e,n){const A={mids:[],starts:[],ends:[],strands:[],mismatches:[]};if(e===null)return A;for(const s of ms(t,e,{bothStrands:!0,mismatches:n}).hits)A.mids.push((s.start+s.end)/2),A.starts.push(s.start),A.ends.push(s.end),A.strands.push(s.strand),A.mismatches.push(s.mismatches);return A}const CI=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to read."),[];if(e===null)return t.note("No reference was chosen. Load the genome’s FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.refusal!==void 0)return t.note(n.refusal),[];const A={parS:{motif:null,pattern:"",mismatches:0},matS:{motif:null,pattern:"",mismatches:0}};for(const N of["parS","matS"]){const k=II(t.params,N);if(k==="")continue;const b=Ye(k);if($e(b)){t.note(`${N}: ${b.reason} Its step was skipped.`);continue}const D=Math.round(T(t.params,`${N}Mismatches`,N==="parS"?1:0));A[N]={motif:b,pattern:k,mismatches:Math.max(0,Math.min(b.length-1,D))}}const s=Math.max(100,Math.round(T(t.params,"window",5e3))),r=Math.max(10,Math.min(s,Math.round(T(t.params,"step",1e3)))),o=Math.max(4,Math.min(40,Math.round(T(t.params,"knots",10)))),i=at(t.params,"coverage"),a=new Set(t.framing.circular??[]),c=On(t),l=c.length>0?c.map(N=>N.name):n.contigs.map(N=>N.name),g=$n(t.params,"sequences"),f=g===null?l:l.filter(N=>g.includes(N));if(f.length===0)return t.note("No sequence is ticked, so there is nothing to read."),[];const h=new et,u=new et,I=new et;let d=0,C=0;const E=[],B=new Map,Q=[];for(let N=0;N<f.length;N++){const k=f[N];t.progress(N,f.length,k);const b=n.bases(k);if(b===void 0){Q.push(k);continue}const D=b.length;if(D<4*s){Q.push(k);continue}const F=a.has(k),R=Vi(b,r),v=SA(Zi(R,Math.max(1,Math.round(s/r)),F)),x=iI(ji(v),r,D);if(!Number.isFinite(x.low)||!Number.isFinite(x.high)){Q.push(k);continue}const Y=Ur(b,A.parS.motif,A.parS.mismatches),J=Ur(b,A.matS.motif,A.matS.mismatches);let K,V=Number.NaN;if(i!==null){const L=(await t.sample(i,[{contig:k,start:0,end:D}],dI)).regions[0];if(L!==void 0&&L.values.length>3){const $=new Float64Array(L.values.length),Dt=new Float64Array(L.values.length);for(let P=0;P<L.values.length;P++)$[P]=(L.starts[P]+L.ends[P])/2,Dt[P]=L.values[P];const Ut=lI($,Dt,D,o,F);K=Ut.at,B.set(k,Ut.at),V=fI(Ut.fitted).ratio}}const H=cI({length:D,circular:F,low:x.low,high:x.high,parS:Y.mids,matS:J.mids,...K===void 0?{}:{coverageAt:K}}),ht=Math.floor(s/2),Gt=`${oA[H.rule]}${H.agreesWithSkew?"":" · disagrees with the skew"}`;for(const[q,L]of[["ori",H.ori],["ter",H.ter]])h.add(k,Math.max(0,L-ht),Math.min(D,L+ht),{name:q,detail:q==="ter"?`terminus · ${Gt}`:"origin"});for(let q=0;q<Y.starts.length;q++)u.add(k,Y.starts[q],Y.ends[q],{strand:Y.strands[q],name:"parS",score:Y.mismatches[q],detail:`${Y.mismatches[q]} ${Y.mismatches[q]===1?"mismatch":"mismatches"}`});for(let q=0;q<J.starts.length;q++)I.add(k,J.starts[q],J.ends[q],{strand:J.strands[q],name:"matS",score:J.mismatches[q],detail:`${J.mismatches[q]} ${J.mismatches[q]===1?"mismatch":"mismatches"}`});d+=Y.starts.length,C+=J.starts.length,H.agreesWithSkew||t.note(`${k}: the terminus was placed ${oA[H.rule]}, at the cumulative skew’s minimum — which is where the skew alone would put the origin. Check the assembly, or the motifs.`),E.push({sequence:k,length:D,topology:F?"circular":"linear",ori:H.ori+1,ter:H.ter+1,rule:oA[H.rule],parS:Y.starts.length,parSCluster:H.parS?.count??0,matS:J.starts.length,ratio:V})}if(t.progress(f.length,f.length,"done"),Q.length>0&&t.note(`${Q.length.toLocaleString()} ${Q.length===1?"sequence was":"sequences were"} not placed — not in the reference, or shorter than four skew windows: ${Q.slice(0,6).join(", ")}${Q.length>6?", …":""}.`),E.length===0)return[];i===null&&t.note("No coverage track was chosen, so there is no ori/ter ratio and no coverage step.");const m=E.filter(N=>N.topology==="linear").length;m>0&&t.note(`${m.toLocaleString()} ${m===1?"sequence was":"sequences were"} read as linear. A bacterial chromosome is usually circular — tick it in the Chromosomes table and run this again, or the origin at its first base is split between its two ends.`);const w=[{kind:"intervals",id:"oriter-loci",label:`Origin and terminus · ${t.inputs.labels?.[e]??"reference"}`,payload:{kind:"features",data:h.finish()},noun:{one:"locus",many:"loci"},display:"lane",look:"point"}];d>0&&w.push({kind:"intervals",id:"oriter-pars",label:`parS sites · ${A.parS.pattern}`,payload:{kind:"features",data:u.finish()},noun:{one:"site",many:"sites"},display:"lane",look:"point"}),C>0&&w.push({kind:"intervals",id:"oriter-mats",label:`matS sites · ${A.matS.pattern}`,payload:{kind:"features",data:I.finish()},noun:{one:"site",many:"sites"},display:"lane",look:"point"});const y=t.framing.binsize;if(B.size>0&&y>0&&c.length>0){const N=c.reduce((F,R)=>F+Math.max(1,Math.ceil(R.length/y)),0),k=new Float32Array(N).fill(Number.NaN);let b=0;for(const F of c){const R=Math.max(1,Math.ceil(F.length/y)),v=B.get(F.name);if(v!==void 0)for(let x=0;x<R;x++)k[b+x]=v(Math.min(F.length-1,(x+.5)*y));b+=R}const D=t.inputs.labels?.[i??""]??"coverage";w.push({kind:"profile",id:"oriter-coverage-fit",label:`${D} · spline fit`,values:k,extent:[0,N],binsize:y,unit:""})}return w.push({kind:"table",id:"oriter-table",label:"Origin and terminus per sequence",columns:[{key:"sequence",label:"sequence",kind:"text"},{key:"length",label:"length",kind:"number"},{key:"topology",label:"read as",kind:"text"},{key:"ori",label:"ori",kind:"number",hint:"Centre of the origin locus, 1-based."},{key:"ter",label:"ter",kind:"number",hint:"Centre of the terminus locus, 1-based."},{key:"rule",label:"terminus placed by",kind:"text"},{key:"parS",label:"parS",kind:"number",hint:"Sites found on this sequence."},{key:"parSCluster",label:"in cluster",kind:"number",hint:"parS sites within an eighth of the sequence of the densest one."},{key:"matS",label:"matS",kind:"number",hint:"Sites found on this sequence."},{key:"ratio",label:"ori/ter",kind:"number",digits:2,hint:"Highest over lowest smoothed coverage: copies of the origin per copy of the terminus."}],rows:E}),w};function LA(t,e,n){const A=t.contigs.indexOf(e);if(A<0)return[];const s=[];for(let r=t.contigAt[A];r<t.contigAt[A+1];r++){const o=t.start[r],i=t.end[r];if(i<=o)continue;const a=s[s.length-1];a!==void 0&&o<=a[1]?a[1]=Math.max(a[1],i):s.push([o,i])}return s}function vr(t){let e=0;for(const[n,A]of t)e+=A-n;return e}function QI(t,e){let n=0,A=0,s=0;for(;A<t.length&&s<e.length;){const r=Math.max(t[A][0],e[s][0]),o=Math.min(t[A][1],e[s][1]);o>r&&(n+=o-r),t[A][1]<e[s][1]?A++:s++}return n}function Tr(t,e,n,A){const s=t.contigs.indexOf(e);if(s<0||n.length===0)return 0;let r=0,o=0;for(let i=t.contigAt[s];i<t.contigAt[s+1];i++){const a=t.start[i],c=t.end[i],l=c-a;if(l<=0)continue;for(;o<n.length&&n[o][1]<=a;)o++;let g=0;for(let f=o;f<n.length&&n[f][0]<c;f++)g+=Math.max(0,Math.min(c,n[f][1])-Math.max(a,n[f][0]));g/l>=A&&g>0&&r++}return r}function ea(t,e,n){const A=new Set([...t.contigs,...e.contigs]);let s=0,r=0,o=0,i=0,a=0;for(const l of A){const g=LA(t,l,n.minFraction),f=LA(e,l,n.minFraction);s+=vr(g),r+=vr(f),o+=QI(g,f),i+=Tr(t,l,f,n.minFraction),a+=Tr(e,l,g,n.minFraction)}const c=s+r-o;return{basesA:s,basesB:r,intersection:o,union:c,jaccard:c>0?o/c:Number.NaN,featuresAHit:i,featuresBHit:a,featuresA:t.length,featuresB:e.length}}function BI(t,e,n,A,s){let r=0,o=0,i=0,a=0,c=0,l=Number.NaN,g=Number.NaN;const f=()=>{if(!Number.isNaN(l)){for(o+=g-l;c<A.length&&A[c][1]<=l;)c++;for(let h=c;h<A.length&&A[h][0]<g;h++)r+=Math.min(g,A[h][1])-Math.max(l,A[h][0])}};for(let h=0;h<n.length;h++){const u=n[h],I=t[u],d=I+e[u];for(;a<A.length&&A[a][1]<=I;)a++;let C=0;for(let B=a;B<A.length&&A[B][0]<d;B++)C+=Math.max(0,Math.min(d,A[B][1])-Math.max(I,A[B][0]));const E=d-I;E>0&&C>0&&C/E>=s&&i++,Number.isNaN(l)?(l=I,g=d):I<=g?g=Math.max(g,d):(f(),l=I,g=d)}return f(),{intersection:r,covered:o,hits:i}}function iA(t,e){const n=e.length;let A=0;for(let c=0;c<n;c++)A+=e[c];const s=n>0?A/n:Number.NaN;let r=0;for(let c=0;c<n;c++)r+=(e[c]-s)**2;const o=n>1?Math.sqrt(r/(n-1)):Number.NaN;let i=0,a=0;for(let c=0;c<n;c++)e[c]>=t&&i++,e[c]<=t&&a++;return{observed:t,mean:s,sd:o,z:o>0?(t-s)/o:Number.NaN,fold:s>0?t/s:Number.NaN,pEnriched:(i+1)/(n+1),pDepleted:(a+1)/(n+1)}}function EI(t,e,n){const A=ea(t,e,{minFraction:n.minFraction}),s=[],r=[],o=[];for(const I of t.contigs){const d=t.contigs.indexOf(I),C=[];let E=0;for(let m=t.contigAt[d];m<t.contigAt[d+1];m++){const p=t.end[m]-t.start[m];p<=0||(C.push(p),E=Math.max(E,t.end[m]))}if(C.length===0)continue;let Q=n.lengthOf(I);if(Q===void 0||Q<=0){const m=e.contigs.indexOf(I);let p=E;if(m>=0)for(let w=e.contigAt[m];w<e.contigAt[m+1];w++)p=Math.max(p,e.end[w]);Q=p,r.push(I)}if(!Number.isFinite(Q)||Q<=0){o.push(I);continue}s.push({contig:I,length:Q,lengths:C,runs:LA(e,I)})}if(s.length===0)return null;const i=Math.max(1,Math.trunc(n.iterations)),a=Hi(n.seed),c=new Float64Array(i),l=new Float64Array(i),g=new Float64Array(i);let f=0;for(const I of s)f=Math.max(f,I.lengths.length);const h=new Float64Array(f),u=new Int32Array(f);for(let I=0;I<i;I++){if(n.cancelled?.()===!0)return null;let d=0,C=0,E=0;for(const Q of s){const m=Q.lengths.length;for(let y=0;y<m;y++){const N=Math.max(0,Q.length-Q.lengths[y]);h[y]=Math.floor(a()*(N+1)),u[y]=y}const p=u.subarray(0,m);p.sort((y,N)=>h[y]-h[N]);const w=BI(h,Q.lengths,p,Q.runs,n.minFraction);d+=w.intersection,C+=w.covered,E+=w.hits}l[I]=d,g[I]=E;const B=C+A.basesB-d;c[I]=B>0?d/B:Number.NaN,n.onProgress?.(I+1,i)}return{iterations:i,jaccard:iA(A.jaccard,c),intersection:iA(A.intersection,l),featuresHit:iA(A.featuresAHit,g),assumedLengths:r,droppedContigs:o}}const mI=async t=>{const e=ne(t.inputs.features,t.params,"a"),n=ne(t.inputs.features,t.params,"b"),A=e.value,s=n.value;if(A===void 0||s===void 0){const u=[e,n].filter(d=>d.value===void 0),I=u.filter(d=>d.chosen).length;return t.note(I===u.length?`The interval ${u.length===2?"sets":"set"} chosen ${u.length===2?"are":"is"} no longer loaded. Re-open the file, or pick another.`:`Two interval sets are needed and ${u.length===2&&I===0?"neither has":"one has not"} been chosen. Load two BED files, or a BED and a GTF, and pick one in each box.`),[]}t.progress(0,1,"comparing");const r=ea(A,s,{minFraction:Math.max(0,Math.min(1,T(t.params,"minFraction",1e-6)))});t.progress(1,1,"done"),Number.isFinite(r.jaccard)||t.note("Neither set covers any bases, so there is nothing to compare.");const i=[{kind:"table",id:"overlap",label:"Overlap",columns:[{key:"measure",label:"Measure",kind:"text"},{key:"value",label:"Value",kind:"number",digits:4},{key:"note",label:"Note",kind:"text"}],rows:[{measure:"Jaccard (bases)",value:r.jaccard,note:"Symmetric; 1 is identical."},{measure:"Shared bases",value:r.intersection,note:""},{measure:"Bases in either",value:r.union,note:""},{measure:"Bases in the first",value:r.basesA,note:"After merging its own overlaps."},{measure:"Bases in the second",value:r.basesB,note:"After merging its own overlaps."},{measure:"First set hit",value:r.featuresA===0?Number.NaN:r.featuresAHit/r.featuresA,note:`${r.featuresAHit.toLocaleString()} of ${r.featuresA.toLocaleString()} features.`},{measure:"Second set hit",value:r.featuresB===0?Number.NaN:r.featuresBHit/r.featuresB,note:`${r.featuresBHit.toLocaleString()} of ${r.featuresB.toLocaleString()} features.`}]}];if(!Lt(t.params,"shuffle",!1))return i;const a=st(t.params,"shuffleWhich","a")!=="b",c=Math.max(20,Math.trunc(T(t.params,"iterations",1e3)));t.progress(0,c,"shuffling");const l=EI(a?A:s,a?s:A,{minFraction:Math.max(0,Math.min(1,T(t.params,"minFraction",1e-6))),iterations:c,seed:T(t.params,"seed",1),lengthOf:u=>t.lengthOf(u),cancelled:()=>t.cancelled(),onProgress:(u,I)=>t.progress(u,I,"shuffling")});if(t.throwIfCancelled(),l===null)return t.note("The set chosen to move occupies no sequence this session knows a length for, so there was nothing to shuffle it within. Load the assembly — a chrom.sizes, or the map itself."),i;l.assumedLengths.length>0&&t.note(`${l.assumedLengths.length.toLocaleString()} sequence${l.assumedLengths.length===1?" has":"s have"} no known length, so the null was drawn over the furthest position either set reaches there — which is shorter than the sequence and overstates the enrichment. ${l.assumedLengths.slice(0,6).join(", ")}${l.assumedLengths.length>6?", …":""}.`),l.droppedContigs.length>0&&t.note(`${l.droppedContigs.length.toLocaleString()} sequence${l.droppedContigs.length===1?"":"s"} could not be shuffled at all and ${l.droppedContigs.length===1?"is":"are"} left out of the null: ${l.droppedContigs.slice(0,6).join(", ")}${l.droppedContigs.length>6?", …":""}.`);const g=a?"first":"second",f=(u,I,d)=>({measure:u,observed:I.observed,expected:I.mean,fold:I.fold,z:I.z,p:I.observed>=I.mean?I.pEnriched:I.pDepleted,tail:I.observed>=I.mean?"enriched":"depleted",digits:d}),h=[f("Jaccard (bases)",l.jaccard,4),f("Shared 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Error{constructor(e){super(e),this.name="IdrError"}}const hn=new Float64Array(1),$r=new Int32Array(hn.buffer),na=new Uint8Array(Float64Array.of(1).buffer)[7]===63?1:0,wI=1-na,Yr=.8450629115104675,pI=.1283791670955126,yI=1.0270333367641007,Me=[.12837916709551256,-.3250421072470015,-.02848174957559851,-.005770270296489442,-23763016656650163e-21],Fe=[.39791722395915535,.0650222499887673,.005081306281875766,.00013249473800432164,-3960228278775368e-21],zt=[-.0023621185607526594,.41485611868374833,-.3722078760357013,.31834661990116175,-.11089469428239668,.035478304325618236,-.002166375594868791],ce=[.10642088040084423,.540397917702171,.07182865441419627,.12617121980876164,.01363708391202905,.011984499846799107],Tt=[-.009864944034847148,-.6938585727071818,-10.558626225323291,-62.375332450326006,-162.39666946257347,-184.60509290671104,-81.2874355063066,-9.814329344169145],Jt=[19.651271667439257,137.65775414351904,434.56587747522923,645.3872717332679,429.00814002756783,108.63500554177944,6.570249770319282,-.0604244152148581],Xt=[-.0098649429247001,-.799283237680523,-17.757954917754752,-160.63638485582192,-637.5664433683896,-1025.0951316110772,-483.5191916086514],Vt=[30.33806074348246,325.7925129965739,1536.729586084437,3199.8582195085955,2553.0504064331644,474.52854120695537,-22.44095244658582];function Or(t){hn[0]=t;const e=$r[na],n=e&2147483647;if(n>=2146435072)return 1-(e>>>31<<1)+1/t;if(n<1072365568){if(n<1043333120)return n<8388608?.125*(8*t+yI*t):t+pI*t;const c=t*t,l=Me[0]+c*(Me[1]+c*(Me[2]+c*(Me[3]+c*Me[4]))),g=1+c*(Fe[0]+c*(Fe[1]+c*(Fe[2]+c*(Fe[3]+c*Fe[4])))),f=l/g;return t+t*f}if(n<1072955392){const c=Math.abs(t)-1,l=zt[0]+c*(zt[1]+c*(zt[2]+c*(zt[3]+c*(zt[4]+c*(zt[5]+c*zt[6]))))),g=1+c*(ce[0]+c*(ce[1]+c*(ce[2]+c*(ce[3]+c*(ce[4]+c*ce[5])))));return e>=0?Yr+l/g:-Yr-l/g}if(n>=1075314688)return e>=0?1-1e-300:1e-300-1;const A=Math.abs(t),s=1/(A*A);let r,o;n<1074191214?(r=Tt[0]+s*(Tt[1]+s*(Tt[2]+s*(Tt[3]+s*(Tt[4]+s*(Tt[5]+s*(Tt[6]+s*Tt[7])))))),o=1+s*(Jt[0]+s*(Jt[1]+s*(Jt[2]+s*(Jt[3]+s*(Jt[4]+s*(Jt[5]+s*(Jt[6]+s*Jt[7])))))))):(r=Xt[0]+s*(Xt[1]+s*(Xt[2]+s*(Xt[3]+s*(Xt[4]+s*(Xt[5]+s*Xt[6]))))),o=1+s*(Vt[0]+s*(Vt[1]+s*(Vt[2]+s*(Vt[3]+s*(Vt[4]+s*(Vt[5]+s*Vt[6]))))))),hn[0]=A,$r[wI]=0;const i=hn[0],a=Math.exp(-i*i-.5625)*Math.exp((i-A)*(i+A)+r/o);return e>=0?1-a/A:a/A-1}function un(t,e,n,A){const s=(t-e)/n;return .5*A*Or(s/Math.SQRT2)+.5*(1-A)*Or(t/Math.SQRT2)+.5}function _r(t,e,n,A,s,r,o){let i=0;for(let a=0;a<1e3;a++){i=s+(r-s)/2;const c=un(i,e,n,A);if(Math.abs(c-t)<o)return i;c<t?s=i:r=i}return i}function xA(t,e,n,A,s,r){const o=qr(t.length,n,A,s,r),i=e.length===t.length?o:qr(e.length,n,A,s,r);return[Kr(t,o),Kr(e,i)]}function Kr(t,e){const n=new Float64Array(t.length);for(let A=0;A<t.length;A++)n[A]=e[t[A]];return n}function qr(t,e,n,A,s){const r=new Float64Array(t);if(t===0)return r;const o=t+1,i=1/o;let a=0<=e?0:e;for(;un(a,e,n,A)>i;)a-=1;let c=0>=e?0:e;for(;un(c,e,n,A)<1-i;)c+=1;a=_r(i,e,n,A,a,c,s),r[0]=a;for(let l=1;l<t;l++){const g=(l+1)/o;un(c,e,n,A)<g&&(c+=10);const f=_r(g,e,n,A,a,c,s);r[l]=f,a=f,c=a+2*(f-r[l-1])}return r}class Aa{constructor(e,n){this.z1=e,this.z2=n,this.n=e.length,this.noise=new Float64Array(this.n),this.signal=new Float64Array(this.n),this.terms=new Float64Array(this.n),Hr(0,1,0,e,n,this.noise)}n;noise;signal;terms;at=[Number.NaN,Number.NaN,Number.NaN];logLik(e){this.signalAt(e);const n=e[3];for(let A=0;A<this.n;A++)this.terms[A]=Math.log(n*this.signal[A]+(1-n)*this.noise[A]);return Bt(this.terms)}membership(e){this.signalAt(e);const n=e[3],A=new Float64Array(this.n);for(let s=0;s<this.n;s++){const r=n*this.signal[s];A[s]=r/(r+(1-n)*this.noise[s])}return A}signalAt(e){const n=this.at;e[0]===n[0]&&e[1]===n[1]&&e[2]===n[2]||(Hr(e[0],e[1],e[2],this.z1,this.z2,this.signal),this.at=[e[0],e[1],e[2]])}}function Hr(t,e,n,A,s,r){const o=-1.837877-Math.log(e)-Math.log(e)-.5*Math.log(1-n*n),i=2*n,a=2*(1-n*n);for(let c=0;c<A.length;c++){const l=(A[c]-t)/e,g=(s[c]-t)/e;r[c]=Math.exp(o-(l*l-i*l*g+g*g)/a)}}function NI(t,e){const{n,z1:A,z2:s}=t,r=t.membership(e),o=Bt(r),i=new Float64Array(n);for(let I=0;I<n;I++)i[I]=r[I]*A[I];const a=Bt(i)/o;for(let I=0;I<n;I++)i[I]=r[I]*s[I];const c=Bt(i)/o,l=(a+c)/2;for(let I=0;I<n;I++){const d=A[I]-l;i[I]=r[I]*(d*d)}const g=Bt(i);for(let I=0;I<n;I++){const d=s[I]-l;i[I]=r[I]*(d*d)}const f=Bt(i),h=Math.sqrt((g+f)/(2*o));for(let I=0;I<n;I++)i[I]=r[I]*(A[I]-l)*(s[I]-l);const u=2*Bt(i)/(g+f);return[l,h,u,o/n]}function sa(t){const e=[t[0],t[1],t[2],t[3]];let n=!1;return e[0]<Ct[0]&&(e[0]=Ct[0],n=!0),e[1]<Ct[1]&&(e[1]=Ct[1],n=!0),e[2]<Ct[2]?(e[2]=Ct[2],n=!0):e[2]>ee[2]&&(e[2]=ee[2],n=!0),e[3]<Ct[3]?(e[3]=Ct[3],n=!0):e[3]>ee[3]&&(e[3]=ee[3],n=!0),{theta:e,changed:n}}function kI(t,e,n,A){let s=e,r=t.logLik(s),o=[e[0],e[1],e[2],e[3]];for(let i=0;i<n;i++){const a=sa(NI(t,s));o=a.theta;const c=t.logLik(o);if(a.changed)return{theta:o,changed:!0};if(!(c+1e-6>=r))throw new se("An EM step lowered the likelihood, which stops idr’s own fit.");if(c-r<A)return{theta:o,changed:!1};s=o,r=c}return{theta:o,changed:!1}}function bI(t,e,n,A=1e-5,s=500){if(!Number.isFinite(e)||!Number.isFinite(n))throw new se("Optimization bounds must be finite scalars.");if(e>n)throw new se("The lower bound exceeds the upper bound.");const r=Math.sqrt(22e-17),o=.5*(3-Math.sqrt(5));let i=e,a=n,c=i+o*(a-i),l=c,g=c,f=0,h=0,u=g,I=t(u),d=1,C=I,E=I,B=.5*(i+a),Q=r*Math.abs(g)+A/3,m=2*Q;for(;Math.abs(g-B)>m-.5*(a-i);){let p=!0;if(Math.abs(h)>Q){p=!1;let N=(g-l)*(I-C),k=(g-c)*(I-E),b=(g-c)*k-(g-l)*N;if(k=2*(k-N),k>0&&(b=-b),k=Math.abs(k),N=h,h=f,Math.abs(b)<Math.abs(.5*k*N)&&b>k*(i-g)&&b<k*(a-g)){if(f=(b+0)/k,u=g+f,u-i<m||a-u<m){const D=Math.sign(B-g)+(B-g===0?1:0);f=Q*D}}else p=!0}p&&(h=g>=B?i-g:a-g,f=o*h);const w=Math.sign(f)+(f===0?1:0);u=g+w*Math.max(Math.abs(f),Q);const y=t(u);if(d+=1,y<=I?(u>=g?i=g:a=g,c=l,C=E,l=g,E=I,g=u,I=y):(u<g?i=u:a=u,y<=E||l===g?(c=l,C=E,l=u,E=y):(y<=C||c===g||c===l)&&(c=u,C=y)),B=.5*(i+a),Q=r*Math.abs(g)+A/3,m=2*Q,d>=s)break}return g}function DI(t,e,n){const A=[e[0],e[1],e[2],e[3]],s=e[n],r=c=>(A[n]=s+c,-t.logLik(A));if(!(s>=Ct[n])||!(s<=ee[n]))throw new se("A coordinate-ascent step started outside idr’s parameter box.");const o=bI(r,Ct[n]-s,ee[n]-s),i=-r(0),a=-r(o);return a>i?(e[n]+=o,a):i}function MI(t,e,n,A){let s=t.logLik(e),r=[e[0],e[1],e[2],e[3]],o=s;for(let i=0;i<n;i++){for(let c=0;c<4;c++)o=DI(t,r,c);const a=sa(r);if(a.changed)throw new se("Coordinate ascent left idr’s parameter box, which stops idr’s own fit.");if(r=a.theta,!(o+1e-6>=s))throw new se("A coordinate-ascent round lowered the likelihood, which stops idr’s own fit.");if(o-s<A)return r;s=o}return r}async function FI(t,e,n={}){const A=n.eps??$t.convergenceEps,s=n.maxIter??$t.maxIter,r=$t.pseudoValueEps,o=n.start??$t.start;let i=[o[0],o[1],o[2],o[3]],[a,c]=xA(t,e,i[0],i[1],i[3],r),l=!1,g=0;const f=new Float64Array(t.length);for(let h=0;h<s;h++){g=h+1;const u=i,I=new Aa(a,c),d=kI(I,u,$t.emStepsPerRound,A/10);i=d.theta,d.changed&&(l=!0,i=MI(I,u,$t.emStepsPerRound,A/10));const C=Bt([Math.abs(i[0]-u[0]),Math.abs(i[1]-u[1]),Math.abs(i[2]-u[2]),Math.abs(i[3]-u[3])]),E=a,B=c;[a,c]=xA(t,e,i[0],i[1],i[3],r);for(let p=0;p<f.length;p++)f[p]=Math.abs(E[p]-a[p]);const Q=MA(f);for(let p=0;p<f.length;p++)f[p]=Math.abs(B[p]-c[p]);const m=Q+MA(f);if(n.between!==void 0&&await n.between(g),h>3&&C<A&&m<A)break}return{theta:i,rounds:g,coordinateAscent:l}}function SI(t,e,n){const A=$t.finalPseudoValueEps,[s,r]=xA(e,n,t[0],t[1],t[3],A),o=new Aa(s,r).membership(t),i=$t.convergenceEps,a=new Float64Array(o.length);for(let c=0;c<a.length;c++){let l=1-o[c];s[c]+r[c]<0&&(l=1),a[c]=l<i?i:l>1?1:l}return a}function RI(t){const e=t.length,n=Array.from({length:e},(o,i)=>i);n.sort((o,i)=>t[o]-t[i]||o-i);const A=new Float64Array(e);let s=0,r=0;for(;r<e;){let o=r;for(;o<e&&t[n[o]]===t[n[r]];)s+=t[n[o]],o++;const i=s/o;for(let a=r;a<o;a++)A[n[a]]=i;r=o}return A}function GA(t){return-Math.log10(Math.max(1e-5,t))}function Wr(t){const e=t.length,n=Array.from({length:e},(s,r)=>r);n.sort((s,r)=>t[s]-t[r]||s-r);const A=new Int32Array(e);for(let s=0;s<e;s++)A[n[s]]=s;return A}const nn={width:150,times:3,minWidth:75,truncate:1e5},LI=[-1/560,8/315,-1/5,8/5,-205/72,8/5,-1/5,8/315,-1/560],xI=1e6,GI=1e-10;function UI(t,e){let n=Float64Array.from(LI);const A=new Float64Array(t).fill(1/t);for(let o=0;o<e;o++)n=vI(n,A);const s=new Float64Array(n.length);for(let o=0;o<n.length;o++)s[o]=xI*n[n.length-1-o];const r=new Float64Array(s.length+1);for(let o=0;o<s.length;o++)r[o+1]=r[o]+s[o];return{width:t,times:e,values:s,cumulative:r}}function vI(t,e){const n=new Float64Array(t.length+e.length-1);for(let A=0;A<n.length;A++){let s=0;const r=Math.max(0,A-(e.length-1)),o=Math.min(A,t.length-1);for(let i=r;i<=o;i++)s+=t[i]*e[A-i];n[A]=s}return n}function ws(t,e){return Math.min(e,t.values.length)-1>>1}function TI(t,e){const n=ws(t,e);return{left:t.values.length-1-n,right:n}}function JI(t,e,n,A,s){const r=[],o=[],i=[],a=(l,g,f)=>{const h=i.length-1;if(h>=0&&o[h]===l&&ra(i[h],f)){o[h]=g;return}r.push(l),o.push(g),i.push(f)};let c=A;for(let l=0;l<t.length&&c<s;l++){const g=Math.max(t[l],c),f=Math.min(e[l],s);f<=g||(g>c&&a(c,g,Number.NaN),a(g,f,n[l]),c=f)}return c<s&&a(c,s,Number.NaN),{starts:Int32Array.from(r),ends:Int32Array.from(o),values:Float64Array.from(i),length:r.length}}function $I(t,e){return{starts:Int32Array.of(t),ends:Int32Array.of(e),values:Float64Array.of(0),length:1}}function YI(t,e,n){if(t.length===1)return t[0];const A=[],s=[],r=[],o=new Int32Array(t.length);let i=e;for(;i<n;){let a=n,c=0;for(let f=0;f<t.length;f++){const h=t[f];for(;o[f]<h.length&&h.ends[o[f]]<=i;)o[f]++;const u=o[f];if(u>=h.length||h.starts[u]>i)throw new Error(`pooledRuns: a track does not cover ${i}`);c+=h.values[u],h.ends[u]<a&&(a=h.ends[u])}const l=Math.fround(c/t.length),g=r.length-1;g>=0&&ra(r[g],l)?s[g]=a:(A.push(i),s.push(a),r.push(l)),i=a}return{starts:Int32Array.from(A),ends:Int32Array.from(s),values:Float64Array.from(r),length:A.length}}function ra(t,e){return t===e||t!==t&&e!==e}function Pr(t,e,n,A,s,r,o){const i=e.values.length,a=ws(e,n),c=new Float64Array(Math.max(0,s-A));if(o===void 0)zr(t,e,a,A,s,c,A);else{let l=0;for(;l<c.length;){const g=o.indexOf(1,l),f=g<0||g>c.length?c.length:g;if(c.fill(Number.NaN,l,f),f===c.length)break;const h=o.indexOf(0,f),u=h<0||h>c.length?c.length:h;zr(t,e,a,A+f,A+u,c,A),l=u}}if(r!==void 0)for(let l=0;l<t.length;l++){const g=Math.max(A,t.starts[l]-a+i-1),f=Math.min(s-1,t.ends[l]-a-1);g<=f&&r.fill(1,g-A,f-A+1)}return c}function zr(t,e,n,A,s,r,o){const i=e.values.length,a=e.values,c=e.cumulative,l=t.starts,g=t.ends,f=t.values,h=A+n+1,u=s+n,I=-(n+1)-o;let d=0,C=t.length;for(;d<C;){const Q=d+C>>>1;g[Q]>h-i?C=Q:d=Q+1}const E=c[0],B=c[i];for(;d<t.length;d++){const Q=l[d];if(Q+1>u)break;const m=g[d],p=f[d];let w=Q+1>h?Q+1:h,y=m-1<Q+i?m-1:Q+i;if(y>u&&(y=u),w<=y){let k=w;k===Q+1&&(r[I+k]+=p*a[0],k++);for(let b=I+k,D=k-Q,F=I+y;b<=F;b++,D++)r[b]+=p*(c[D]-E)}if(w=m>h?m:h,y=Q+i<u?Q+i:u,w<=y)if(m-Q===1)for(let k=I+w,b=w-1-Q,D=I+y;k<=D;k++,b++)r[k]+=p*a[b];else for(let k=I+w,b=w-Q,D=w-m,F=I+y;k<=F;k++,b++,D++)r[k]+=p*(c[b]-c[D]);if(w=Q+i+1>h?Q+i+1:h,y=m-1<u?m-1:u,w<=y){const k=p*(B-E);for(let b=I+w,D=I+y;b<=D;b++)r[b]+=k}w=m>Q+i+1?m:Q+i+1,w<h&&(w=h);const N=m+i-1;if(y=N<u?N:u,w<=y){const k=I+(y===N?y-1:y);for(let b=I+w,D=w-m;b<=k;b++,D++)r[b]+=p*(B-c[D]);y===N&&(r[I+N]+=p*a[i-1])}}}const OI=65536;function oa(t){return Math.fround(t)<GI}function _I(t){const e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)oa(t[n])&&(e[n]=1);return e}class Xr{constructor(e,n,A){this.contig=e,this.length=n,this.tracks=A.length,this.absent=A,this.scores=A.map(()=>[]),this.held=A.map(()=>new Float64Array(1024))}tracks;absent;starts=[];ends=[];modes=[];flats=[];scores;previous=!1;rose=!1;open=-1;best=Number.NEGATIVE_INFINITY;ties=[];held;heldLength=0;openFlat=0;position=0;feed(e,n,A,s){if(e!==this.position)throw new Error(`ConcaveScan: fed ${e} after ${this.position}`);for(let r=0;r<n.length;r++){const o=e+r,i=Math.fround(n[r]),a=oa(i);if(o===0?a&&this.begin(0):a&&!this.previous?(this.rose=!0,this.begin(o)):!a&&this.previous&&this.close(o),a){const c=-i;c>this.best?(this.best=c,this.ties=[o]):c===this.best&&this.ties.push(o),this.hold(A,r),s!==void 0&&s[r]===1&&(this.openFlat=1)}this.previous=a}this.position=e+n.length}finish(){if(this.open>=0&&this.close(this.length),!this.rose){this.starts=[],this.ends=[],this.modes=[],this.flats=[];for(const e of this.scores)e.length=0}return{contig:this.contig,starts:Int32Array.from(this.starts),ends:Int32Array.from(this.ends),modes:Int32Array.from(this.modes),scores:this.scores.map(e=>Float64Array.from(e)),flat:Uint8Array.from(this.flats)}}begin(e){this.open=e,this.best=Number.NEGATIVE_INFINITY,this.ties=[],this.heldLength=0,this.openFlat=0,this.held[0].length>OI&&(this.held=this.held.map(()=>new Float64Array(1024)))}hold(e,n){this.heldLength===this.held[0].length&&(this.held=this.held.map(A=>{const s=new Float64Array(A.length*2);return s.set(A),s}));for(let A=0;A<this.tracks;A++)this.held[A][this.heldLength]=e[A][n];this.heldLength++}close(e){this.starts.push(this.open),this.ends.push(e),this.flats.push(this.openFlat),this.modes.push(this.ties.length===0?this.open:this.ties[this.ties.length>>1]);for(let n=0;n<this.tracks;n++)this.scores[n].push(this.absent[n]?Number.NEGATIVE_INFINITY:-MA(this.held[n],0,this.heldLength));this.open=-1}}function KI(t){const e=t.length,n=Array.from({length:e},(r,o)=>o);n.sort((r,o)=>t[o]-t[r]||r-o);const A=new Float64Array(e);let s=0;for(;s<e;){let r=s+1;for(;r<e&&t[n[r]]===t[n[s]];)r++;const o=(s+1+r)/2;for(let i=s;i<r;i++)A[n[i]]=o;s=r}return A}function qI(t,e,n,A,s){const r=e.length,o=new Float64Array(r).fill(Number.POSITIVE_INFINITY);for(const l of A){const g=KI(l);for(let f=0;f<r;f++)g[f]<o[f]&&(o[f]=g[f])}const i=(l,g)=>t[l]<t[g]?-1:t[l]>t[g]?1:e[l]-e[g]||n[l]-n[g],a=Array.from({length:r},(l,g)=>g);a.sort((l,g)=>o[l]-o[g]||i(l,g));const c=a.slice(0,Math.max(0,Math.min(r,s)));return c.sort(i),Int32Array.from(c)}class HI{constructor(e,n,A={}){this.tracks=e,this.limit=n,this.scores=Array.from({length:e},()=>new Float64Array(1024)),this.floor=new Float64Array(e).fill(Number.NEGATIVE_INFINITY),A.prune===!1&&(this.holdAll=!0),this.below=A.below===!0?new Float64Array(1024):null}size=0;contigs=[];starts=new Int32Array(1024);ends=new Int32Array(1024);modes=new Int32Array(1024);flats=new Uint8Array(1024);scores;floor;seen=0;dropped=0;holdAll=!1;below;belowSize=0;add(e,n){this.seen++;let A=this.holdAll;for(let r=0;r<this.tracks;r++){const o=e.scores[r][n];o!==o&&!this.holdAll&&(this.holdAll=!0,A=!0),o>=this.floor[r]&&(A=!0)}if(!A){this.drop(e.scores[0][n],e.flat[n]);return}this.size===this.starts.length&&this.grow();const s=this.size++;this.contigs[s]=e.contig,this.starts[s]=e.starts[n],this.ends[s]=e.ends[n],this.modes[s]=e.modes[n],this.flats[s]=e.flat[n];for(let r=0;r<this.tracks;r++)this.scores[r][s]=e.scores[r][n];!this.holdAll&&this.size>=2*this.tracks*this.limit+1024&&this.prune()}finish(){this.holdAll||this.prune();const e=this.size,n={contig:this.contigs.slice(0,e),starts:this.starts.slice(0,e),ends:this.ends.slice(0,e),modes:this.modes.slice(0,e),flat:this.flats.slice(0,e),scores:this.scores.map(A=>A.slice(0,e))};return{...n,tested:qI(n.contig,n.starts,n.ends,n.scores,this.limit),below:this.below===null?new Float64Array(0):this.below.slice(0,this.belowSize),exact:!(this.holdAll&&this.dropped>0)}}prune(){if(this.seen<this.limit)return;const e=this.size;for(let A=0;A<this.tracks;A++){const s=this.scores[A].slice(0,e).sort();this.floor[A]=s[e-this.limit]}let n=0;for(let A=0;A<e;A++){let s=!1;for(let r=0;r<this.tracks;r++)this.scores[r][A]>=this.floor[r]&&(s=!0);if(!s){this.drop(this.scores[0][A],this.flats[A]);continue}if(n!==A){this.contigs[n]=this.contigs[A],this.starts[n]=this.starts[A],this.ends[n]=this.ends[A],this.modes[n]=this.modes[A],this.flats[n]=this.flats[A];for(let r=0;r<this.tracks;r++)this.scores[r][n]=this.scores[r][A]}n++}this.size=n,this.contigs.length=n}drop(e,n){if(this.dropped++,!(this.below===null||!(e>0)||n===1)){if(this.belowSize===this.below.length){const A=new Float64Array(this.below.length*2);A.set(this.below),this.below=A}this.below[this.belowSize++]=e}}grow(){const e=n=>{const A=new n.constructor(n.length*2);return A.set(n),A};this.starts=e(this.starts),this.ends=e(this.ends),this.modes=e(this.modes),this.flats=e(this.flats),this.scores=this.scores.map(e)}}function WI(t,e,n,A,s){return A>0?[Math.max(0,n-A),Math.min(s,n+A+1)]:[t,e]}function ia(t){return-(Math.log(t)/Math.log(10))}const aa=[.001,.005,.01,.05,.1,.2],aA="0.05";function ca(t){return typeof t.replicate=="string"&&t.replicate!==""}const PI="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",zI=8,XI=-1,VI=-2;let le;function ZI(){if(le!==void 0)return le;le=null;try{if(typeof WebAssembly>"u")return null;const t=atob(PI),e=new Uint8Array(t.length);for(let n=0;n<t.length;n++)e[n]=t.charCodeAt(n);WebAssembly.validate(e)&&(le=new WebAssembly.Module(e))}catch{le=null}return le}class UA extends Error{constructor(){super("The peak-calling kernel ran out of memory."),this.name="KernelMemoryError"}}class jI{size=0;starts=new Int32Array(1024);ends=new Int32Array(1024);modes=new Int32Array(1024);flats=new Uint8Array(1024);scores;constructor(e){this.scores=Array.from({length:e},()=>new Float64Array(1024))}take(e,n,A){if(A===0)return;for(;this.size+A>this.starts.length;)this.grow();const s=e.buffer,r=n.scan_region_capacity();this.starts.set(new Int32Array(s,n.scan_region_starts()>>>0,A),this.size),this.ends.set(new Int32Array(s,n.scan_region_ends()>>>0,A),this.size),this.modes.set(new Int32Array(s,n.scan_region_modes()>>>0,A),this.size),this.flats.set(new Uint8Array(s,n.scan_region_flats()>>>0,A),this.size);const o=n.scan_regions()>>>0;this.scores.forEach((i,a)=>i.set(new Float64Array(s,o+a*r*8,A),this.size)),this.size+=A}grow(){const e=n=>{const A=new n.constructor(n.length*2);return A.set(n),A};this.starts=e(this.starts),this.ends=e(this.ends),this.modes=e(this.modes),this.flats=e(this.flats),this.scores=this.scores.map(e)}}class ps{constructor(e,n,A,s){this.memory=e,this.exports=n,this.contig=A,this.tracks=s,this.collected=new jI(s)}collected;static open(e,n,A,s,r){const o=ZI();if(o===null||s<1||s>zI)return null;try{const i=new WebAssembly.Memory({initial:2}),c=new WebAssembly.Instance(o,{env:{memory:i}}).exports,l=e.values.length;if(c.scan_open(s,l,ws(e,A),A,r)!==0)return null;const g=c.scan_kernel()>>>0;return new Float64Array(i.buffer,g,l).set(e.values),new Float64Array(i.buffer,g+l*8,l+1).set(e.cumulative),new ps(i,c,n,s)}catch{return null}}window(e,n,A,s,r){let o=0;for(let i=0;i<this.tracks;i++){const a=r[i];if(a===null){o|=1<<i;continue}const c=a.starts.length,l=this.exports.scan_input(i,c)>>>0;if(l===0)throw new UA;const g=this.memory.buffer;new Float64Array(g,l,c).set(a.values),new Int32Array(g,l+c*8,c).set(a.starts),new Int32Array(g,l+c*12,c).set(a.ends)}this.closed(this.exports.scan_window(e,n,A,s,o),e)}lastWindow(e){const n=this.memory.buffer;return{pooled:new Float64Array(n,this.exports.scan_pooled()>>>0,e).slice(),flat:new Uint8Array(n,this.exports.scan_flat()>>>0,e).slice(),own:Array.from({length:this.tracks},(A,s)=>new Float64Array(n,this.exports.scan_own(s)>>>0,e).slice())}}finish(){this.closed(this.exports.scan_finish(),-1);const{collected:e}=this,n=this.exports.scan_rose()===1?e.size:0;return{contig:this.contig,starts:e.starts.slice(0,n),ends:e.ends.slice(0,n),modes:e.modes.slice(0,n),scores:e.scores.map(A=>A.slice(0,n)),flat:e.flats.slice(0,n)}}closed(e,n){if(e===XI)throw new UA;if(e===VI)throw new Error(`ConcaveScan: fed ${n} out of order`);if(e<0)throw new Error(`pooledRuns: a track does not cover a window at ${n}`);this.collected.take(this.memory,this.exports,e)}}const cA=1<<18,Vr=20,An=2e4,Zr=["#0072b2","#009e73"],td="#999999",ed=async t=>{const e=at(t.params,"signal");if(e===null)return t.note("No track was chosen. Load a bigWig and pick it under Track."),[];const n=ca(t.params)?at(t.params,"replicate"):null;if(n===e)return t.note("The replicate chosen is the track being called, and a track cannot test itself. Choose a second track, or none."),[];const A=n===null?[e]:[e,n],s=L=>t.inputs.labels?.[L]??L,r=Se(T(t.params,"width",nn.width),1,2e3),o=Se(T(t.params,"times",nn.times),0,10),i=Se(T(t.params,"minWidth",nn.minWidth),1,1e9),a=Se(T(t.params,"halfWidth",0),0,1e9),c=Se(T(t.params,"truncate",nn.truncate),1,1e9),l=Ad(t),g=t.inputs.contigLengths??{},f=$n(t.params,"sequences"),h=Object.keys(g).filter(L=>g[L]>0&&(f===null||f.includes(L)));if(h.length===0)return t.note(f!==null&&f.length===0?"No sequence is ticked, so there is nothing to call peaks on.":"This session knows no sequence lengths, so there is nothing to scan. Load a chrom.sizes, or the map itself."),[];const u=UI(r,o),I=L=>nd(t,A,h,g,u,{minWidth:i,truncate:c,below:n===null,prune:L});let d=await I(!0);if(typeof d!="string"&&!d.held.exact&&(d=await I(!1)),typeof d=="string")return t.note(d),[];const{held:C,found:E,n:B,perSequence:Q,absentOn:m}=d;for(let L=0;L<A.length;L++){if(m[L].length===h.length)return t.note(`${s(A[L])} has none of the ${h.length===1?"sequence":"sequences"} ticked. Check that it and the assembly name their sequences the same way.`),[];m[L].length>0&&t.note(`${s(A[L])} has no ${gd(m[L])}. yapc reads a track that lacks a sequence as zeros there, so it lowers the mean the regions are called on, and ranks every region there last by it.`)}const p=`${u.values.length}-tap kernel: a ${r.toLocaleString()} bp window, ${o} ${o===1?"pass":"passes"}`;if(B===0)return t.note(`No concave region at least ${i.toLocaleString()} bp wide on ${h.length===1?h[0]:`${h.length} sequences`} (${p}). A wider smoothing window finds broader shapes; a narrower minimum keeps smaller ones.`),[];const{contig:w,starts:y,ends:N,modes:k,flat:b,scores:D,tested:F}=C;t.note(`${E.toLocaleString()} concave ${E===1?"region":"regions"} on ${h.length.toLocaleString()} ${h.length===1?"sequence":"sequences"} (${p}), ${B.toLocaleString()} at least ${i.toLocaleString()} bp wide`+(F.length<B?`, of which the ${F.length.toLocaleString()} strongest by each track’s curvature rank were kept.`:"."));let R=null,v=null,x=null;const Y=new Uint8Array(F.length).fill(1);if(n!==null)if(F.length<Vr)t.note(`IDR needs at least ${Vr} peaks to fit — its own command refuses fewer — and there ${F.length===1?"is 1":`are ${F.length}`}. They are reported untested, ranked by curvature.`);else{const L=Wr(sn(D[0],F)),$=Wr(sn(D[1],F)),Dt=eo(sn(D[0],F))+eo(sn(D[1],F));Dt>0&&t.note(`${Dt.toLocaleString()} ${Dt===1?"score ties":"scores tie"} with another: ranked by position, where yapc breaks a tie at random.`);try{R=await FI(L,$,{between:async P=>{t.progress(0,0,`IDR, round ${P}`),await Cs(),t.throwIfCancelled()}})}catch(P){throw P instanceof se?new Error(`IDR could not fit these two tracks, as idr itself could not: ${P.message}`):P}v=SI(R.theta,L,$),x=RI(v);const Ut=ia(l);for(let P=0;P<F.length;P++)Y[P]=GA(x[P])>=Ut?1:0;t.note(sd(R,F.length,cd(Y),l))}else{let L=0;for(let $=0;$<F.length;$++)b[F[$]]!==0&&(Y[$]=0,L++);L>0&&t.note(`${L.toLocaleString()} of the candidates ${L===1?"is":"are"} flat — the signal constant across a whole kernel’s width inside, which yapc’s test counts as concave — and ${L===1?"is":"are"} left out, as IDR would leave ${L===1?"it":"them"} out of two replicates.`),t.note("One track, so no test of significance: yapc’s cut is IDR between two replicates. These are the strongest concave regions by curvature — choose a replicate to test them, or lower “keep the strongest” to the upper of the two populations in the figure.")}const J=new Map(h.map((L,$)=>[L,$])),K=[];for(let L=0;L<F.length;L++)Y[L]===1&&K.push(L);K.sort((L,$)=>(J.get(w[F[L]])??0)-(J.get(w[F[$]])??0)||y[F[L]]-y[F[$]]);const V=new et;let H=0,ht=0;for(const L of K){const $=F[L],[Dt,Ut]=WI(y[$],N[$],k[$],a,g[w[$]]);a>0&&(Dt!==k[$]-a||Ut!==k[$]+a+1)&&H++;const P=[`summit ${(k[$]+1).toLocaleString("en-US")}`];P.push(`curvature ${A.map((LQ,ec)=>no(D[ec][$])).join(" / ")}`),x!==null&&P.push(`IDR ${no(x[L])}`),V.add(w[$],Dt,Ut,{name:`peak_${++ht}`,score:x!==null?GA(x[L]):D[0][$],cds:[k[$],k[$]+1],detail:P.join(ct)})}H>0&&t.note(`${H.toLocaleString()} ${H===1?"peak reaches":"peaks reach"} past a sequence end at this half-width and ${H===1?"is":"are"} cut at it; yapc writes the coordinate past the end.`),K.length===0&&t.note(`No peak passes IDR ≤ ${l}. A looser threshold keeps more; two tracks that are not replicates of one experiment will pass few at any.`);const Gt=[];K.length>0&&Gt.push({kind:"intervals",id:`peaks-${A.map(L=>L.replace(/[^A-Za-z0-9_]+/g,"_")).join("-")}`,label:n===null?`Peaks · ${s(e)} · no IDR`:`Peaks · ${s(e)} + ${s(n)} · IDR ≤ ${l}`,payload:{kind:"features",data:V.finish()},noun:{one:"peak",many:"peaks"},lane:{under:{entry:e}},display:"lane",look:"point"});const q=rd(A.map(s),D,F,Y,n!==null,b,C.below);return q!==null&&Gt.push(q),Gt.push(od(h,g,Q,K.map(L=>w[F[L]]))),R!==null&&x!==null&&Gt.push(id(x,l)),Lt(t.params,"perPeak",!1)&&Gt.push(ad({names:A.map(s),contig:w,starts:y,ends:N,modes:k,scores:D,tested:F,passes:Y,local:v,global:x,replicate:n!==null})),t.progress(1,1,"done"),Gt};async function nd(t,e,n,A,s,r){const o=n.reduce((h,u)=>h+A[u],0);let i=0;const a=new HI(e.length,r.truncate,{prune:r.prune,below:r.below}),c=e.map(()=>[]),l=new Map;let g=0,f=0;for(const h of n){const u=await la(t,e,h,A[h],s,C=>{i+=C,t.progress(i,o,h)});if(typeof u=="string")return u;const{regions:I}=u;let d=0;for(let C=0;C<I.starts.length;C++)I.ends[C]-I.starts[C]<r.minWidth||(d++,a.add(I,C));g+=I.starts.length,f+=d,l.set(h,{regions:I.starts.length,wide:d}),u.absent.forEach((C,E)=>{C&&c[E].push(h)})}return{held:a.finish(),found:g,n:f,perSequence:l,absentOn:c}}async function la(t,e,n,A,s,r,o="auto"){const{left:i,right:a}=TI(s,A),c=e.map(()=>!1),l=o==="js"?null:ps.open(s,n,A,e.length,cA);let g=null,f=0;try{for(let h=0;h<A;h+=cA){const u=Math.min(A,h+cA),I=Math.max(0,h-i),d=Math.min(A,u+a),C=[];for(let E=0;E<e.length;E++){if(c[E]){C.push(null);continue}const B=await t.sample(e[E],[{contig:n,start:I,end:d}],1);if(B.note!==void 0)return B.note;const Q=B.regions[0];Q===void 0&&(c[E]=!0),C.push(Q??null)}if(l!==null)l.window(h,u,I,d,C);else{const E=C.map(w=>w===null?$I(I,d):JI(w.starts,w.ends,w.values,I,d));g??=new Xr(n,A,c);const B=new Uint8Array(u-h),Q=Pr(YI(E,I,d),s,A,h,u,B),m=e.length===1?null:_I(Q),p=m===null?[Q]:E.map(w=>Pr(w,s,A,h,u,void 0,m));g.feed(h,Q,p,B)}r(u-h),f+=u-h,await Cs(),t.throwIfCancelled()}}catch(h){if(!(h instanceof UA))throw h;return r(-f),la(t,e,n,A,s,r,"js")}return l!==null?{regions:l.finish(),absent:c}:{regions:(g??new Xr(n,A,c)).finish(),absent:c}}function Ad(t){const e=Number(st(t.params,"idr",aA));return aa.includes(e)?e:(ca(t.params)&&t.note(`An IDR threshold of ${st(t.params,"idr","")} is not one yapc writes; ${aA} was used.`),Number(aA))}const jr=["mean","spread","correlation","reproducible share"];function sd(t,e,n,A){const[s,r,o,i]=t.theta,a=`IDR fitted over ${e.toLocaleString()} peaks in ${t.rounds.toLocaleString()} rounds: μ ${s.toFixed(2)}, σ ${r.toFixed(2)}, ρ ${o.toFixed(2)}, reproducible share ${i.toFixed(2)}; ${n.toLocaleString()} pass IDR ≤ ${A}.`,c=[],l=g=>Number.isInteger(g)?String(g):g.toFixed(2);return t.theta.forEach((g,f)=>{const[h,u]=[Jr.min[f],Jr.max[f]];g<=h+1e-4*Math.max(1,h)?c.push(`the ${jr[f]} at its floor of ${l(h)}`):g>=u-1e-4*Math.max(1,u)&&c.push(`the ${jr[f]} at its ceiling of ${l(u)}`)}),c.length===0?a:`${a} The fit ended at the edge of IDR’s parameter box — ${c.join(", ")} — which is where two tracks that do not rank their peaks like replicates of one experiment put it. Read these IDRs as that, not as reproducibility.`}function rd(t,e,n,A,s,r,o){const i=[],a=new Uint8Array(r.length);for(const f of n)a[f]=1;for(let f=0;f<e.length;f++){const h=[],u=[];if(n.forEach((E,B)=>{const Q=e[f][E];!(Q>0)||!s&&r[E]===1||(A[B]===1?h.push(Q):u.push(Q))}),!s){for(let E=0;E<r.length;E++)a[E]===0&&e[f][E]>0&&r[E]===0&&u.push(e[f][E]);for(const E of o)u.push(E)}const I=e.length===1?"":`${t[f]} · `,d=s?`${I}passes IDR`:`${I}peaks`,C=s?`${I}fails IDR`:`${I}below the cut`;h.length>0&&i.push(to(d,h,Zr[f]??Zr[0])),u.length>0&&i.push(to(C,u,td))}if(i.length===0)return null;const c=i.flatMap(f=>Array.from(f.y)),l=ld(c,.01);let g=Number.NEGATIVE_INFINITY;for(const f of c)f>g&&(g=f);return{kind:"curve",id:"peaks-curvature",label:"Curvature of every candidate",series:i,xLabel:"",yLabel:"Curvature (yapc score)",xScale:"linear",yScale:"log",...Number.isFinite(l)&&l>0&&g>l?{yDomain:[10**Math.floor(Math.log10(l)),10**Math.ceil(Math.log10(g))]}:{}}}function to(t,e,n){const A=Float64Array.from(e).sort();let s=A;if(A.length>An){s=new Float64Array(An);for(let r=0;r<An;r++)s[r]=A[Math.round(r*(A.length-1)/(An-1))]}return{name:t,x:Float64Array.from(s,(r,o)=>o),y:s,colour:n,n:e.length,mark:"violin"}}function od(t,e,n,A){const s=new Map;for(const r of A)s.set(r,(s.get(r)??0)+1);return{kind:"table",id:"peaks-sequences",label:"Per sequence",columns:[{key:"sequence",label:"Sequence",kind:"text"},{key:"length",label:"Length",kind:"number"},{key:"regions",label:"Concave regions",kind:"number"},{key:"wide",label:"Wide enough",kind:"number"},{key:"peaks",label:"Peaks",kind:"number"},{key:"density",label:"Peaks per Mb",kind:"number",digits:1}],rows:t.map(r=>{const o=n.get(r)??{regions:0,wide:0},i=s.get(r)??0;return{sequence:r,length:e[r],regions:o.regions,wide:o.wide,peaks:i,density:i/e[r]*1e6}})}}function id(t,e){const n=t.length;return{kind:"table",id:"peaks-idr",label:"IDR thresholds",columns:[{key:"threshold",label:"IDR ≤",kind:"text"},{key:"peaks",label:"Peaks",kind:"number"},{key:"share",label:"Share of tested",kind:"number",digits:3},{key:"drawn",label:"Drawn",kind:"text"}],rows:aa.map(A=>{const s=ia(A);let r=0;for(let o=0;o<n;o++)GA(t[o])>=s&&r++;return{threshold:String(A),peaks:r,share:r/n,drawn:A===e?"yes":""}})}}function ad(t){const{names:e,contig:n,starts:A,ends:s,modes:r,scores:o,tested:i,passes:a,local:c,global:l}=t,g=[];return i.forEach((f,h)=>{const u={sequence:n[f],start:A[f],end:s[f],summit:r[f],width:s[f]-A[f]};o.forEach((I,d)=>{u[`curvature${d}`]=I[f]}),c!==null&&l!==null&&(u.local=c[h],u.idr=l[h],u.passes=a[h]===1?"yes":"no"),g.push(u)}),l!==null?g.sort((f,h)=>Number(f.idr)-Number(h.idr)):g.sort((f,h)=>Number(h.curvature0)-Number(f.curvature0)),{kind:"table",id:"peaks-list",label:t.replicate?"Every peak tested":"Every peak",columns:[{key:"sequence",label:"Sequence",kind:"text"},{key:"start",label:"Start",kind:"number",coordinate:"start"},{key:"end",label:"End",kind:"number",coordinate:"end"},{key:"summit",label:"Summit",kind:"number",coordinate:"start",hint:"The most concave base."},{key:"width",label:"Width",kind:"number"},...e.map((f,h)=>({key:`curvature${h}`,label:e.length===1?"Curvature":`Curvature · ${f}`,kind:"number",digits:2})),...c!==null?[{key:"local",label:"Local IDR",kind:"number",digits:4,scientific:!0},{key:"idr",label:"IDR",kind:"number",digits:4,scientific:!0},{key:"passes",label:"Passes",kind:"text"}]:[]],rows:g}}function Se(t,e,n){return Math.min(n,Math.max(e,Math.round(t)))}function sn(t,e){const n=new Float64Array(e.length);for(let A=0;A<e.length;A++)n[A]=t[e[A]];return n}function cd(t){let e=0;for(const n of t)e+=n;return e}function eo(t){const e=Float64Array.from(t).sort();let n=0;for(let A=1;A<e.length;A++)e[A]===e[A-1]&&n++;return n}function ld(t,e){if(t.length===0)return Number.NaN;const n=Float64Array.from(t).sort(),A=e*(n.length-1),s=Math.floor(A),r=Math.min(n.length-1,s+1);return n[s]+(A-s)*(n[r]-n[s])}function no(t){return Number.isFinite(t)?Number(t.toPrecision(4)).toLocaleString("en-US",{maximumSignificantDigits:4}):t>0?"∞":t<0?"−∞":"—"}function gd(t){return t.length===1?t[0]:t.length<=3?`${t.slice(0,-1).join(", ")} and ${t[t.length-1]}`:`${t.slice(0,3).join(", ")} and ${(t.length-3).toLocaleString()} more`}const ga=[{name:"DpnII",site:"GATC",cut:0},{name:"HindIII",site:"AAGCTT",cut:1},{name:"NcoI",site:"CCATGG",cut:1},{name:"EcoRI",site:"GAATTC",cut:1},{name:"BglII",site:"AGATCT",cut:1},{name:"HinfI",site:"GANTC",cut:1},{name:"DdeI",site:"CTNAG",cut:1},{name:"MseI",site:"TTAA",cut:1},{name:"NlaIII",site:"CATG",cut:4},{name:"CviQI",site:"GTAC",cut:1},{name:"AluI",site:"AGCT",cut:2}],fd={MboI:"DpnII",Sau3AI:"DpnII",Csp6I:"CviQI"},Mn={Arima:["DpnII","HinfI"]},hd=(()=>{const t=new Map;for(const e of ga)t.set(e.name.toLowerCase(),e);for(const[e,n]of Object.entries(fd)){const A=t.get(n.toLowerCase());A!==void 0&&t.set(e.toLowerCase(),A)}return t})();function rn(t){return hd.get(t.trim().toLowerCase())}function Fn(t){const e=t.trim().toLowerCase();return Object.keys(Mn).find(n=>n.toLowerCase()===e)}function fa(t){return`${t.site.slice(0,t.cut)}^${t.site.slice(t.cut)}`}function ud(t){return t.site.length-2*t.cut}const Id=1/256,Ao=255;function so(t){let e=1;for(const n of t){let A=0;for(let s=n;s!==0;s&=s-1)A++;e*=A/4}return e}function dd(t){const e=t.toUpperCase().replace(/U/g,"T"),n=e.indexOf("^"),A=e.replace("^","");if(n<0){const r=Ye(A);return{refusal:$e(r)?`“${t}” is neither an enzyme this knows nor a site in IUPAC letters with a ^ where it cuts.`:`“${t}” needs a ^ where the enzyme cuts the top strand, as in ^GATC or G^ANTC.`}}if(A.includes("^"))return{refusal:`“${t}” has more than one ^, and a site is cut in one place.`};const s=Ye(A);return $e(s)?{refusal:s.reason}:so(s)>Id?{refusal:`“${t}” would cut every ${Math.round(1/so(s))} bases or so; a site needs at least the specificity of a four-base cutter.`}:{name:`${e.slice(0,n)}^${e.slice(n+1)}`,site:A,cut:n}}function Cd(t,e){const n=t.trim();if(n===""||n==="none")return[];if(n!=="custom"){const i=Fn(n);if(i!==void 0)return Mn[i].map(c=>rn(c));const a=rn(n);return a===void 0?{refusal:`“${n}” is not an enzyme or a kit this knows. Pick one, or type its site under custom.`}:[a]}const A=e.split(/[\s,;]+/).filter(i=>i!=="");if(A.length===0)return{refusal:"Type an enzyme or a site, such as DpnII or G^ANTC."};const s=[],r=new Set,o=i=>{const a=`${i.site}^${i.cut}`;r.has(a)||(r.add(a),s.push(i))};for(const i of A){const a=Fn(i);if(a!==void 0){for(const g of Mn[a])o(rn(g));continue}const c=rn(i);if(c!==void 0){o(c);continue}const l=dd(i);if("refusal"in l)return l;o(l)}return s.length>Ao?{refusal:`That is ${s.length} enzymes, and one digest takes ${Ao} at most.`}:s}function Qd(t){return t.map(e=>e.name).join("+")}function Bd(t){let e=0;for(const n of t)e=Math.max(e,n.site.length);return Math.max(0,e-1)}const ro=new Map;function Ed(t){const e=`${t.site}^${t.cut}`,n=ro.get(e);if(n!==void 0)return n;const A=Ye(t.site);if($e(A))throw new Error(`${t.name}: ${A.reason}`);const s={motif:A,offset:t.cut};return ro.set(e,s),s}const Ce=256;function ha(t,e,n,A,s){const r=t.subarray(0,e).sort();let o=0,i=Number.NaN;for(let c=0;c<r.length;c++){const l=Math.floor(r[c]/Ce);l===i||!(l>A&&l<s)||(i=l,r[o++]=r[c])}const a={top:new Int32Array(o),bottom:new Int32Array(o),enzyme:new Uint8Array(o)};for(let c=0;c<o;c++){const l=Math.floor(r[c]/Ce),g=r[c]-l*Ce;a.top[c]=l,a.bottom[c]=l+n[g],a.enzyme[c]=g}return a}function md(t,e,n=0){let A=new Float64Array(Math.max(16,t.length>>7)),s=0;e.forEach((o,i)=>{const a=Ed(o),{hits:c}=ms(t,a.motif,{bothStrands:!0,offset:n});if(s+c.length>A.length){const l=new Float64Array(Math.max(A.length*2,s+c.length));l.set(A.subarray(0,s)),A=l}for(const l of c)A[s++]=(l.start+a.offset)*Ce+i});const r=Int32Array.from(e,ud);return ha(A,s,r,Number.NEGATIVE_INFINITY,Number.POSITIVE_INFINITY)}function wd(t,e){let n=0;for(const o of t)n+=o.top.length;const A=new Float64Array(n),s=new Int32Array(Ce);let r=0;for(const o of t)for(let i=0;i<o.top.length;i++)A[r++]=o.top[i]*Ce+o.enzyme[i],s[o.enzyme[i]]=o.bottom[i]-o.top[i];return ha(A,r,s,0,e)}const pd=16e6;[...ga.map(t=>({value:t.name,label:`${t.name} (${fa(t)})`})),...Object.entries(Mn).map(([t,e])=>({value:t,label:`${t} (${e.join(" + ")})`}))];function yd(t){const e=typeof t.enzyme=="string"?t.enzyme:"none",n=typeof t.sites=="string"?t.sites:"";return{choice:e,sites:n}}async function Nd(t,e,n={}){const A=n.contigs??t.contigs,s=Bd(e),r=Math.max(1,Math.floor(n.piece??pd)),o=t.read?.bind(t),i=A.reduce((l,g)=>l+g.length,0);let a=0;const c=[];for(const l of A){const g=o===void 0?t.bases(l.name):void 0;if(o===void 0&&g===void 0)continue;const f=g?.length??l.length,h=[];let u=!0;for(let I=0;I<f;I+=r){n.throwIfCancelled?.();const d=Math.min(f,I+r),C=Math.min(f,d+s),E=g!==void 0?g.subarray(I,C):await o?.(l.name,I,C);if(E===void 0){u=!1;break}h.push(md(E,e,I)),a+=d-I,n.progress?.(a,i,l.name)}u&&c.push({contig:l.name,length:f,cuts:wd(h,f)})}return c}function kd(t,e){const n=Qd(e),A=Fn(t);return A===void 0?n:`${A} (${n})`}function bd(t,e){const n=Fn(t);return n!==void 0?n.replace(/[^A-Za-z0-9]/g,""):e.map(A=>A.name.replace(/\^/g,"_").replace(/[^A-Za-z0-9_]/g,"")).join("-")}const Dd=async t=>{const e=at(t.params,"sequence");if(t.residues===void 0)return t.note("This session cannot read residues, so there is no reference to cut."),[];if(e===null)return t.note("No reference was chosen. Load a FASTA and pick it under Reference."),[];const n=t.residues(e);if(n===void 0)return t.note("The reference chosen is no longer loaded. Drop the FASTA again, or pick another."),[];if(n.read===void 0&&n.refusal!==void 0)return t.note(n.refusal),[];const{choice:A,sites:s}=yd(t.params),r=Cd(A,s);if(!Array.isArray(r))return t.note(r.refusal),[];if(r.length===0)return t.note("No enzyme was chosen, so there is nothing to cut."),[];const o=$n(t.params,"sequences");if(o!==null&&o.length===0)return t.note("No sequence is ticked, so there is nothing to cut."),[];const i=Object.entries(t.inputs.contigLengths??{}).filter(([,Q])=>Q>0).map(([Q])=>Q),a=Xi(n,o,i);if(a.length===0)return t.note("None of the ticked sequences is in this reference, so there is nothing to cut."),[];const c=a.length===n.contigs.length;t.progress(0,1,a.length===1?`cutting ${a[0].name}`:`cutting ${a.length.toLocaleString()} sequences`);const l=await Nd(n,r,{contigs:a,progress:(Q,m,p)=>t.progress(Q,m,`cutting ${p}`),throwIfCancelled:()=>t.throwIfCancelled()});if(t.progress(1,1,"done"),l.length===0)return t.note("None of the ticked sequences could be read from this reference."),[];const g=kd(A,r),f=c?g:a.length<=3?`${g} on ${a.map(Q=>Q.name).join(", ")}`:`${g} on ${a.length.toLocaleString()} sequences`;let h=0,u=0;for(const Q of l)h+=Q.cuts.top.length,u+=Q.length;const I=h+l.length;t.note(h===0?`No ${g} site anywhere in ${c?"this reference":"the sequences ticked"}, so each sequence is one fragment.`:`${h.toLocaleString()} ${g} ${h===1?"cut":"cuts"} on ${l.length.toLocaleString()} ${l.length===1?"sequence":"sequences"}: ${I.toLocaleString()} fragments, ${Math.round(u/I).toLocaleString()} bp long on average.`);const d=`restriction-${bd(A,r)}${c?"":Md(a)}`,C=Fd(l,r),E=[Sd(C,f,d)],B=Rd(t,C,f,d);return B!==null&&E.push(B),E};function Md(t){const e=t.map(A=>A.name);if(e.length<=3)return`-on-${e.map(A=>A.replace(/[^A-Za-z0-9]/g,"")).join("-")}`;let n=5381;for(const A of e.join(`
+`))n=(n*33^A.charCodeAt(0))>>>0;return`-on${e.length}-${n.toString(36)}`}function Fd(t,e){let n=0;for(const i of t)n+=i.cuts.top.length;const A=e.map(i=>i.name),s=e.map(i=>`${i.name} cuts ${fa(i)}`),r={contigs:t.map(i=>i.contig),length:n,contig:new Int32Array(n),start:new Int32Array(n),end:new Int32Array(n),strand:new Int8Array(n),score:new Float32Array(n).fill(Number.NaN),name:new Array(n),id:new Array(n).fill(""),detail:new Array(n),exonAt:new Int32Array(n+1),exonStart:new Int32Array(0),exonEnd:new Int32Array(0),cdsStart:new Int32Array(n).fill(-1),cdsEnd:new Int32Array(n).fill(-1),contigAt:new Int32Array(t.length+1),maxSpan:new Int32Array(t.length)};let o=0;return t.forEach((i,a)=>{const{top:c,enzyme:l}=i.cuts;r.contigAt[a]=o,r.contig.fill(a,o,o+c.length),r.start.set(c,o);for(let g=0;g<c.length;g++)r.end[o+g]=c[g]+1,r.name[o+g]=A[l[g]],r.detail[o+g]=s[l[g]];c.length>0&&(r.maxSpan[a]=1),o+=c.length}),r.contigAt[t.length]=o,r}function Sd(t,e,n){return{kind:"intervals",id:n,label:`${e} sites`,payload:{kind:"features",data:t},noun:{one:"site",many:"sites"},display:"lane",look:"point"}}function Rd(t,e,n,A){const s=t.framing.binsize,r=On(t);if(!(s>0)||r.length===0)return t.note("The sites are a lane; the density is not. A per-bin track needs the bin grid of an open contact map, and this session has none. Open the map and run it again for that half."),null;const o=e.contigs.map((a,c)=>{const l=e.contigAt[c],g=e.contigAt[c+1];return{contig:a,starts:e.start.subarray(l,g),ends:e.end.subarray(l,g),strands:e.strand.subarray(l,g)}}),i=zi({hits:o,total:e.length},r,s);return{kind:"profile",id:`${A}-density`,label:`${n} site density`,values:i.values,extent:[0,i.values.length],binsize:s,unit:"sites"}}const Ld=async t=>{const e=Jn(t.params,"tracks");if(e.length<2)return t.note(e.length===0?"No tracks were chosen. Load two or more bigWigs and tick them under Tracks.":"Only one track was chosen, and a correlation needs two."),[];const n=I=>t.inputs.labels?.[I]??I,A=e.map(n),s=await xd(t);if(s.count===0)return t.note("No unit to compare over. Check that the tracks and the assembly share contig names."),[];const r=[];for(let I=0;I<e.length;I++)t.throwIfCancelled(),t.progress(I,e.length,A[I]),r.push(await Ud(t,e[I],s));t.progress(e.length,e.length,"correlating");const o=vd(r),i=s.kind==="bins"?"windows":"features";if(o<Nn)t.note(`Fewer than ${Nn} of the ${s.count.toLocaleString()} ${i} have a value in every track, so no pair has a coefficient. Check that the tracks cover the same sequences.`);else if(o<s.count){const I=s.count-o,d=I===1;t.note(`${I.toLocaleString()} of the ${s.count.toLocaleString()} ${i} ${d?"has":"have"} no value in at least one track, and ${d?"is":"are"} left out of every pair: every coefficient is over the other ${o.toLocaleString()}.`)}const a=st(t.params,"method","spearman"),c=e.length,l=new Float32Array(c*c),g=[];for(let I=0;I<c;I++){l[I*c+I]=1;for(let d=I+1;d<c;d++){const C=a==="pearson"?vi(r[I],r[d]):Sh(r[I],r[d]);l[I*c+d]=C,l[d*c+I]=C,g.push({a:A[I],b:A[d],r:C})}}const f={kind:"matrix",id:"trackcorr",label:`Track correlation · ${a}`,nrows:c,ncols:c,values:l,xLabel:"",yLabel:"",xTicks:A,yTicks:A,colormap:yl,centre:0,stats:[{label:"units",value:s.count,digits:0},{label:"compared",value:o,digits:0,hint:"Units every track has a value for: the ones every pair is correlated over."}]},h={kind:"table",id:"trackcorr-table",label:"Pairs",columns:[{key:"a",label:"Track",kind:"text"},{key:"b",label:"Track",kind:"text"},{key:"r",label:a==="pearson"?"Pearson r":"Spearman ρ",kind:"number",digits:3}],rows:g.sort((I,d)=>Number(d.r)-Number(I.r))};return[f,h]};async function xd(t){if(st(t.params,"over","bins")==="features"){const s=ne(t.inputs.features,t.params,"features"),r=s.value;if(r===void 0)return t.note(Yn(s,{unchosen:"Correlating over features needs a feature set, and none was chosen.",gone:"The feature set chosen is no longer loaded. Re-open the file, or pick another."})??""),{kind:"features",regions:[],count:0};const o=[];for(let i=0;i<r.length;i++)o.push({contig:r.contigs[r.contig[i]],start:r.start[i],end:r.end[i]});return{kind:"features",regions:o,count:o.length}}const e=Math.max(1,Math.round(T(t.params,"binsize",100))),n=[];let A=0;for(const[s,r]of Object.entries(t.inputs.contigLengths??{})){const o=Math.floor(r/e);o!==0&&(n.push({contig:s,count:o,offset:A}),A+=o)}return{kind:"bins",size:e,tilings:n,count:A}}const Gd=1<<20,oo=4096;async function Ud(t,e,n){const A=new Float64Array(n.count),s=new Float64Array(n.count),r=(o,i,a,c,l,g)=>{const f=Math.min(l,a)-Math.max(c,i);f>0&&(A[o]+=g*f,s[o]+=f)};if(n.kind==="bins"){const{size:o}=n,i=Math.max(1,Math.floor(Gd/o))*o;for(const a of n.tilings){const c=a.count*o;for(let l=0;l<c;l+=i){t.throwIfCancelled();const g=Math.min(c,l+i),f=await t.sample(e,[{contig:a.contig,start:l,end:g}],1);for(const h of f.regions)for(let u=0;u<h.values.length;u++){const I=h.values[u];if(!Number.isFinite(I))continue;const d=Math.max(l,h.starts[u]),C=Math.min(g,h.ends[u]);for(let E=Math.floor(d/o);E*o<C;E++)r(a.offset+E,E*o,(E+1)*o,d,C,I)}}}}else{const o=new Map;n.regions.forEach((i,a)=>{const c=o.get(i.contig);c===void 0?o.set(i.contig,[a]):c.push(a)});for(const[,i]of o)for(let a=0;a<i.length;a+=oo){t.throwIfCancelled();const c=i.slice(a,a+oo),l=await t.sample(e,c.map(f=>n.regions[f]),1),g=new Map;for(const f of l.regions)g.set(`${f.contig}:${f.start}-${f.end}`,f);for(const f of c){const h=n.regions[f],u=g.get(`${h.contig}:${h.start}-${h.end}`);if(u!==void 0)for(let I=0;I<u.values.length;I++){const d=u.values[I];Number.isFinite(d)&&r(f,h.start,h.end,u.starts[I],u.ends[I],d)}}}}for(let o=0;o<A.length;o++)A[o]=s[o]>0?A[o]/s[o]:Number.NaN;return A}function vd(t){const e=t.length===0?0:t[0].length;let n=0;for(let A=0;A<e;A++)if(t.every(s=>!Number.isNaN(s[A])))n++;else for(const s of t)s[A]=Number.NaN;return n}const Td={motif:Lu,restriction:Dd,peaks:ed,composition:_u,dotplot:rI,oriter:CI,metaplot:uu,trackcorr:Ld,frip:xh,groupsignal:zh,overlap:mI},Jd="0.17.0",$d="faa252c";function Yd(t){const e=[],n=new Set;for(const A of t.split(/\r?\n/)){const s=A.trim();if(s===""||s.startsWith("#"))continue;const r=s.split(/\s+/);if(r.length<5)return[];const[o,i,a,c,l]=[r[0],Number(r[1]),Number(r[2]),Number(r[3]),Number(r[4])];if([i,a,c,l].some(f=>!Number.isInteger(f)||f<0))return[];if(c===0||l<c)return[];n.has(o)||(n.add(o),e.push({name:o,length:i,offset:a,lineBases:c,lineWidth:l}))}return e}function Od(t){return t.map(e=>({name:e.name,length:e.length}))}function on(t,e){const n=Math.floor(e/t.lineBases);return t.offset+n*t.lineWidth+(e-n*t.lineBases)}function _d(t,e,n){const A=Math.max(0,Math.min(t.length,Math.floor(e))),s=Math.max(A,Math.min(t.length,Math.ceil(n)));return s<=A?{from:on(t,A),to:on(t,A)}:{from:on(t,A),to:on(t,s-1)+1}}function Kd(t){let e=0;for(let s=0;s<t.length;s++)t[s]>32&&e++;if(e===t.length)return t;const n=new Uint8Array(e);let A=0;for(let s=0;s<t.length;s++)t[s]>32&&(n[A++]=t[s]);return n}const ua=/\.(fa|fasta|fna|fas)$/i;function qd(t){if(/\.b?gz$/i.test(t))return`${t}.tbi`;if(/\.bam$/i.test(t))return`${t}.bai`;if(ua.test(t))return`${t}.fai`}const vA=18,Hd=4,Wd=/\.(biginteract|interact)(\.b?gz)?$/i;function Pd(t){return t!==void 0&&t!==""&&Number.isFinite(Number(t))}function io(t){return t==="+"||t==="-"||t==="."||t===""}function Ia(t,e=""){const n=Wd.test(e);let A=0,s=0;const r=t.length;for(;s<r&&A<Hd;){let o=t.indexOf(`
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+`,n);s<0&&(s=A);let r=s;r>n&&t.charCodeAt(r-1)===13&&r--;const o=t.slice(n,r);if(n=s+1,o===""||o.charCodeAt(0)===35||o.startsWith("track ")||o.startsWith("browser "))continue;const i=o.includes("	")?o.split("	"):o.trim().split(/\s+/);if(Na(i)===null)return!1;e++}return e>0}function IC(t){if(t==="gneg")return 0;if(t.startsWith("gpos")){const e=t.slice(4);if(e==="")return 100;const n=Number(e);return Number.isFinite(n)?Math.max(0,Math.min(100,n)):100}return Number.NaN}function dC(t){const e=t.indexOf(`${TA} `);if(e<0)return"";const n=e+TA.length+1,A=t.indexOf(" ",n);return A<0?t.slice(n):t.slice(n,A)}function ba(t){const e=new et;let n=0;if(wt(t,A=>{const s=Na(A);if(s===null){n++;return}e.add(A[0],Number(A[1]),Number(A[2]),{name:s.name,score:IC(s.stain),detail:`${TA} ${s.stain}`})}),e.length===0&&n>0)throw new Error(`No usable rows: all ${n} lines failed the "sequence, start, end, band, stain" test a cytoBand is made of.`);return e.finish()}function CC(t){const e=[];for(let n=0;n<t.contigs.length;n++){const A=t.contigAt[n],s=t.contigAt[n+1];if(s<=A)continue;let r=0;for(let o=A;o<s;o++){if(t.start[o]!==r)return null;r=t.end[o]}e.push({name:t.contigs[n],length:r})}return e.length>0?e:null}function Da(t){let e=0,n=0;for(let r=0;r<t.length;r++)dC(t.detail[r])==="acen"&&e++,t.name[r]!==""&&n++;const A=t.contigAt.reduce((r,o,i)=>i<t.contigs.length&&t.contigAt[i+1]>t.contigAt[i]?r+1:r,0),s=[`${G.int(t.length)} band${t.length===1?"":"s"}`,`${G.int(A)} sequence${A===1?"":"s"}`];return n<t.length&&s.push(`${G.int(n)} named`),e>0&&s.push(`${G.int(e)} centromeric`),s.join(" · ")}const QC=["non-canonical","GT/AG","GT/AG","GC/AG","GC/AG","AT/AC","AT/AC"],BC="multi",EC="motif",JA="annotated",mC="overhang",wC="anchors",pC=8;function yC(t){const e=[];let n=!1,A=0;const s=t.length;for(;A<s&&e.length<pC;){let r=t.indexOf(`
+`,A);r<0&&(r=s);let o=r;o>A&&t.charCodeAt(o-1)===13&&o--;const i=t.slice(A,o);if(A=r+1,!(i===""||i.charCodeAt(0)===35)){if(i.startsWith("track ")){/junction/i.test(i)&&(n=!0);continue}i.startsWith("browser ")||e.push(i.includes("	")?i.split("	"):i.trim().split(/\s+/))}}return{rows:e,declared:n}}function Ma(t){if(t.length!==9)return!1;for(let s=1;s<9;s++)if(!S(t[s]))return!1;const e=Number(t[3]),n=Number(t[4]),A=Number(t[5]);return Number(t[2])>=Number(t[1])&&e>=0&&e<=2&&n>=0&&n<=6&&(A===0||A===1)}function Fa(t){if(t.length<12||!S(t[1])||!S(t[2])||t[9]!=="2")return null;const e=t[10].split(",").filter(a=>a!==""),n=t[11].split(",").filter(a=>a!=="");if(e.length!==2||n.length!==2||!e.every(S)||!n.every(S))return null;const A=Number(t[1]),s=Number(t[2]),r=Number(e[0]),o=Number(e[1]),i=Number(n[1]);return Number(n[0])!==0||A+i+o!==s||r<=0||o<=0||i<=r?null:[A+r,i-r,o]}function Sa(t){return t.length===6&&S(t[1])&&S(t[2])&&S(t[4])&&(t[5]==="+"||t[5]==="-"||t[5]===".")}function Ns(t,e=""){const{rows:n,declared:A}=yC(t);if(n.length===0)return null;if(n.every(Ma))return"star";const s=/junc|(^|[._-])sj([._-]|$)/i.test(e.replace(/\.b?gz$/i,"")),r=n.every(o=>/^JUNC/i.test(o[3]??""));return(s||A||r)&&n.every(o=>Fa(o)!==null)?"bed":/\.junc(\.b?gz)?$/i.test(e)&&n.every(Sa)?"junc":null}function lo(t){return t==="+"?1:t==="-"?-1:0}function NC(t){if(t===void 0||t===""||t===".")return Number.NaN;const e=Number(t);return Number.isFinite(e)?e:Number.NaN}function Ra(t,e="",n){const A=Ns(t,e);if(A===null)throw new Error("This is not a junction file STAR, regtools or leafcutter wrote.");const s=new et;let r=0;if(wt(t,o=>{if(A==="star"){if(!Ma(o)){r++;return}const i=Number(o[3]),a=Number(o[4]),c=[`${BC} ${o[7]}`,`${EC} ${QC[a]}`,`${JA} ${o[5]==="1"?"yes":"no"}`,`${mC} ${o[8]}`].join(ct);s.add(o[0],Number(o[1])-1,Number(o[2]),{strand:i===1?1:i===2?-1:0,score:Number(o[6]),detail:c});return}if(A==="bed"){const i=Fa(o);if(i===null){r++;return}const[a,c,l]=i,g=a-Number(o[1]),f=o[3]!==void 0&&o[3]!=="."?o[3]:"";s.add(o[0],a,a+c,{strand:lo(o[5]),score:NC(o[4]),name:f,detail:`${wC} ${g}/${l}`});return}if(!Sa(o)){r++;return}s.add(o[0],Number(o[1]),Number(o[2]),{strand:lo(o[5]),score:Number(o[4]),name:o[3]!=="."?o[3]:""})}),s.length===0&&r>0)throw new Error(`No usable rows: all ${r} lines failed the junction test for this file's shape.`);return s.finish()}function La(t){let e=0,n=0,A=!1;for(let r=0;r<t.length;r++){const o=t.score[r];Number.isFinite(o)&&(e+=o);const i=t.detail[r];i.includes(`${JA} `)&&(A=!0,i.includes(`${JA} yes`)&&n++)}const s=[`${G.int(t.length)} junction${t.length===1?"":"s"}`,`${G.int(e)} read${e===1?"":"s"}`];return A&&s.push(`${G.int(n)} annotated`),s.join(ct)}const $A=11,Rn=9,YA=10,kC=4,bC=/\.(bedmethyl|bigmethyl|bed ?methyl)(\.b?gz)?$/i;function xa(t,e=""){const n=bC.test(e);let A=0,s=0;const r=t.length;for(;s<r&&A<kC;){let o=t.indexOf(`
+`,s);o<0&&(o=r);let i=o;i>s&&t.charCodeAt(i-1)===13&&i--;const a=t.slice(s,i);if(s=o+1,a===""||a.charCodeAt(0)===35||a.startsWith("track ")||a.startsWith("browser "))continue;const c=a.includes("	")?a.split("	"):a.trim().split(/\s+/);if(!DC(c,n))return!1;A++}return A>0}function DC(t,e){if(t.length<$A||!S(t[1])||!S(t[2]))return!1;const n=Number(t[YA]);if(t[YA]===""||!Number.isFinite(n))return!1;if(e)return!0;if(!S(t[Rn])||Number(t[Rn])<0||n<0||n>100)return!1;const A=t[5];return A!=="+"&&A!=="-"&&A!=="."?!1:Number(t[2])-Number(t[1])===1}function Ga(t){const e=new Map;fo(t,c=>{if(c.length<$A||!S(c[1])||!S(c[2]))return;const l=go(c[3]);e.set(l,(e.get(l)??0)+1)});const n=[...e.entries()].map(([c,l])=>({code:c,label:ql(c),rows:l})).sort((c,l)=>l.rows-c.rows||c.code.localeCompare(l.code));if(n.length===0)throw new Error("This looks like a bedMethyl but holds no usable rows.");const A=n[0].code,s=new Map;let r=Number.POSITIVE_INFINITY,o=Number.NEGATIVE_INFINITY,i=0,a=0;if(fo(t,c=>{if(c.length<$A||!S(c[1])||!S(c[2])||go(c[3])!==A)return;const l=Number(c[1]),g=Number(c[2]);if(g<=l)return;const f=Number(c[YA]);if(!Number.isFinite(f))return;const h=S(c[Rn])?Number(c[Rn]):0;if(h<=0)return;const u=c[0]??"";let I=s.get(u);I===void 0&&(I=new Is(u),s.set(u,I)),I.push(l,g,f),i++,a+=h,f<r&&(r=f),f>o&&(o=f)}),i===0)throw new Error("This looks like a bedMethyl but every row rests on zero reads, so there is no measurement to draw.");return{signal:ds(s,i,r,o),codes:n,drawn:A,meanCoverage:a/i}}function go(t){return t===void 0||t===""||t==="."?"?":t}function fo(t,e){for(const n of t.split(`
+`)){let A=n;A.endsWith("\r")&&(A=A.slice(0,-1)),!(A===""||A.charCodeAt(0)===35)&&(A.startsWith("track ")||A.startsWith("browser ")||e(A.includes("	")?A.split("	"):A.trim().split(/\s+/)))}}function MC(t){return/\b(percentMod|percentMeth|fractionModified)\b/.test(t)&&/\b(validCov|coverage|Nvalid_cov)\b/.test(t)}function FC(t){const e=t.codes.find(s=>s.code===t.drawn),n=[`${t.signal.length.toLocaleString()} ${e?.label??t.drawn} calls`,`${t.meanCoverage.toFixed(1)}× mean depth`],A=t.codes.filter(s=>s.code!==t.drawn);return A.length>0&&n.push(`not drawn: ${A.map(s=>`${s.label} (${s.rows.toLocaleString()})`).join(", ")}`),n.join(" · ")}const Ln=440477507,xn=".2bit",Ua=16,SC=new Uint8Array([84,67,65,71]),RC=78;function va(t){if(t.length<4)return!1;const e=new DataView(t.buffer,t.byteOffset,4);return e.getUint32(0,!0)===Ln||e.getUint32(0,!1)===Ln}function LC(t){if(t.length<Ua)throw new Error("This file starts like a .2bit and is too short to hold one.");const e=new DataView(t.buffer,t.byteOffset,t.byteLength),n=e.getUint32(0,!0)===Ln;if(!n&&e.getUint32(0,!1)!==Ln)throw new Error("This is not a .2bit: its first four bytes are not the format’s signature.");const A=e.getUint32(4,n);if(A!==0)throw new Error(`This is a .2bit of version ${A}. This viewer reads version 0 — the ordinary one, with 32-bit offsets. Version 1 is the “long” variant for files past 4 GB, whose offsets and sizes are 64-bit, and reading one as though it were version 0 would return wrong residues rather than fail. Convert it with \`twoBitToFa\` and \`faToTwoBit\`.`);const s=e.getUint32(8,n);if(s===0)throw new Error("This .2bit declares no sequences.");return{littleEndian:n,version:A,count:s}}function ho(t,e,n=Ua){const A=new DataView(t.buffer,t.byteOffset,t.byteLength),s=[];let r=n;const o=new TextDecoder;for(;s.length<e.count&&!(r+1>t.length);){const i=t[r];if(r+1+i+4>t.length)break;const a=o.decode(t.subarray(r+1,r+1+i)),c=A.getUint32(r+1+i,e.littleEndian);s.push({name:a,offset:c}),r+=1+i+4}return{entries:s,complete:s.length===e.count,consumed:r}}function uo(t,e,n,A={}){if(e+8>t.length)return 8;const s=new DataView(t.buffer,t.byteOffset,t.byteLength),r=Ta(s,e,n,A),o=e+8+r*8;return o+4>t.length?o+4-e:null}function Ta(t,e,n,A){return nt(t.getUint32(e+4,n),{format:xn,field:`N-block count${A.name===void 0?"":` of ${A.name}`}`,ceiling:t.getUint32(e,n),...A.fileLeft===void 0?{}:{available:A.fileLeft-8-4},bytesPerItem:8})}function xC(t,e,n,A,s=0,r){const o=new DataView(e.buffer,e.byteOffset,e.byteLength),i=o.getUint32(n,A),a=Ta(o,n,A,{name:t,fileLeft:e.length-n}),c=new Int32Array(a),l=new Int32Array(a),g=n+8,f=g+a*4;for(let d=0;d<a;d++){const C=o.getUint32(g+d*4,A);c[d]=C,l[d]=C+o.getUint32(f+d*4,A)}const h=f+a*4,u=nt(o.getUint32(h,A),{format:xn,field:`mask-block count of ${t}`,ceiling:i,...r===void 0?{}:{available:r-(s+h+4)-4},bytesPerItem:8}),I=s+h+4+u*8+4;return r!==void 0&&ns(I,Math.ceil(i/4),{format:xn,field:`packed bases of ${t}`,size:r}),{name:t,length:i,nStarts:c,nEnds:l,dnaAt:I}}const GC=8192;function UC(t,e,n){const A=Math.max(0,Math.min(e,t.length)),s=Math.max(A,Math.min(n,t.length)),r=Math.floor(A/4),o=Math.ceil(s/4);return{from:t.dnaAt+r,to:t.dnaAt+o,firstBase:r*4}}function vC(t,e,n,A,s){const r=Math.max(0,Math.min(A,n.length)),o=Math.max(r,Math.min(s,n.length)),i=new Uint8Array(o-r);for(let a=r;a<o;a++){const c=a-e,l=t[c>>2];if(l===void 0)break;const g=6-((c&3)<<1);i[a-r]=SC[l>>g&3]}for(let a=0;a<n.nStarts.length;a++){const c=n.nStarts[a];if(c>=o)break;const l=n.nEnds[a];l<=r||i.fill(RC,Math.max(r,c)-r,Math.min(o,l)-r)}return i}function TC(t){return t.map(e=>({name:e.name,length:e.length}))}const Io=65536,Co=1e5;async function JC(t,e){let n=await t(Io,0);const A=LC(n);if(A.count>Co)throw new Error(`This .2bit declares ${A.count.toLocaleString()} sequences, which is past the ${Co.toLocaleString()} this viewer will open one record at a time. A file that says this is far more likely to be truncated than to be an assembly.`);let s=ho(n,A);for(;!s.complete;){const a=await t(Io,n.length);if(a.length===0)throw new Error(`This .2bit ends part-way through its index: it declares ${A.count.toLocaleString()} sequences and names ${s.entries.length.toLocaleString()}. The file is truncated.`);const c=new Uint8Array(n.length+a.length);c.set(n),c.set(a,n.length),n=c,s=ho(n,A)}const r=new Map,o=[];let i=0;for(const a of s.entries){e!==void 0&&ns(a.offset,8,{format:xn,field:`index entry for ${a.name}`,size:e});const c={name:a.name,...e===void 0?{}:{fileLeft:e-a.offset}};let l=await t(GC,a.offset),g=uo(l,0,A.littleEndian,c);for(;g!==null;){const h=await t(g,a.offset);if(h.length<=l.length)throw new Error(`This .2bit ends part-way through the record for ${a.name}.`);l=h,g=uo(l,0,A.littleEndian,c)}const f=xC(a.name,l,0,A.littleEndian,a.offset,e);r.set(f.name,f),o.push(f),i+=f.length}return{ordered:o,records:r,total:i}}const $C=2291137574,YC=2273964779,Qo=[137,72,68,70,13,10,26,10];function OC(t){return t.length<Qo.length?!1:Qo.every((e,n)=>t[n]===e)}function Ja(t){if(t.length<4)return null;const e=new DataView(t.buffer,t.byteOffset,4);for(const n of[!0,!1]){const A=e.getUint32(0,n);if(A===$C)return"bigwig";if(A===YC)return"bigbed"}return null}function ft(t,e){const n=we(nl(t),e);for(let A=0;A<n.names.length;A++)t[A]=n.names[A];return n}function Z(t,e,n){const A=Cl(t,Oa(e)),s=_C(t,e),r=n?.contested??[];return{...A,...s===null?{}:{genomes:s},...r.length===0?{}:{contested:r.slice(0,4).map(o=>`${o.asked} → ${o.name}`)}}}function _C(t,e){const n=new Set;for(const r of e)r.genome!==void 0&&r.genome!==""&&n.add(r.genome);if(n.size===0)return null;const A=new Set(t),s=new Set;for(const r of e)r.genome===void 0||r.genome===""||A.has(r.name)&&s.add(r.genome);return{matched:s.size,total:n.size,named:[...s].slice(0,4)}}function _n(t,e){const n=t.bases.get(e);if(n!==void 0)return n;const A=Kt(t.contigs,e);return A<0?void 0:t.bases.get(t.contigs[A].name)}function ks(t,e){const n=t.records.get(e);if(n!==void 0)return n;const A=Kt(t.contigs,e);return A<0?void 0:t.records.get(t.contigs[A].name)}async function $a(t,e,n,A,s){const r=ks(t,e);if(r===void 0)return;const o=Math.max(0,Math.floor(n)),i=Math.min(r.length,Math.ceil(A));if(!(i>o))return new Uint8Array(0);const a=t.held.get(r.name);if(a!==void 0&&a.start<=o&&a.start+a.bases.length>=i)return a.bases.subarray(o-a.start,i-a.start);const c=await Ya(t,r,o,i,s);return t.held.set(r.name,{start:o,bases:c}),c}async function Ya(t,e,n,A,s){const r=s===void 0?{}:{onProgress:s};if(_t(t)){const i=e,a=UC(i,n,A),c=await t.handle.read(a.to-a.from,a.from,r);return vC(c,a.firstBase,i,n,A)}const o=_d(e,n,A);return Kd(await t.handle.read(o.to-o.from,o.from,r))}function Oa(t){return t.map(e=>e.name)}const bs=new Map,Kn=new Map;function Ds(t){return t.indexed===!0}function _t(t){return t.twobit===!0}function me(t){return Ds(t)||_t(t)}const re=new Map,OA=new Map,qn=new Map,Gn=new Map;function KC(t,e){return`${tt(t)}|${tt(e)}`}const Bo=8<<20,Ms=3e8,_A=64e6,Eo=4e6;let Mt=null,oe=null;function tt(t){return t.kind==="local"?`${t.name}|${t.file.size}`:t.url}self.onmessage=t=>{HC(t.data)};const qC=wh();setInterval(()=>{const t={type:"busy",fraction:qC.busy()};self.postMessage(t)},mh);const Hn=new Set,KA=new Set;let qA=0;function HA(t){return Hn.has(t)}async function Fs(t){return await Cs(),!Hn.has(t)}function Pe(){const t=new Error("cancelled");return t.name="AbortError",t}async function HC(t){KA.add(t.id);try{const e=await WC(t);if(HA(t.id))throw Pe();const n={type:"result",id:t.id,payload:e};self.postMessage(n,Ch(e))}catch(e){const n={type:"error",id:t.id,message:e instanceof Error?e.message:String(e),...e instanceof Error&&e.name==="AbortError"?{cancelled:!0}:{}};self.postMessage(n)}finally{KA.delete(t.id),Hn.delete(t.id),t.id>qA&&(qA=t.id)}}function dn(t){return(e,n)=>{const A={type:"progress",id:t,done:e,total:n??0};self.postMessage(A)}}async function WC(t){switch(t.kind){case"load":return eQ(t.entry,t.source,t.mapContigs,dn(t.id));case"sample":return Xa(t.entry,t.regions,t.basesPerPixel,t.reads,t.id,t.exact===!0);case"register":return OA.set(t.entry,t.vector),null;case"run":return PC(t);case"bases":return hQ(t.entry,t.regions,dn(t.id));case"assembly":return zC(t.source,dn(t.id));case"reads":return FQ(t.entry,t.regions,t.maxRows,t.basesPerPixel,t.reads,t.id);case"cancel":return(KA.has(t.target)||t.target>qA)&&Hn.add(t.target),null;case"drop":{bs.delete(t.entry);const e=re.get(t.entry);e!==void 0&&oe?.store===e&&(oe=null),re.delete(t.entry),OA.delete(t.entry),Kn.delete(t.entry),qn.delete(t.entry);for(const[n,A]of Gn)if(A.holders.delete(t.entry)){A.holders.size===0&&Gn.delete(n);break}return null}}}async function PC(t){const e=Td[t.task];if(e===void 0)throw new Error(`no track analysis runner is registered for the task ${t.task}`);const n=[],A=performance.now(),s={params:t.params,framing:t.framing,inputs:t.inputs,cancelled:()=>HA(t.id),throwIfCancelled:()=>{if(HA(t.id))throw Pe()},progress:(o,i,a)=>{const c={type:"progress",id:t.id,done:o,total:i,...a===void 0?{}:{note:a}};self.postMessage(c)},note:o=>{n.push(o)},sample:(o,i,a)=>Xa(o,i,a,void 0,t.id),lengthOf:o=>t.inputs.contigLengths?.[o],residues:o=>{const i=re.get(o);if(i!==void 0)return me(i)?{contigs:i.contigs,bases:()=>{},read:async(a,c,l)=>{const g=ks(i,a);if(g===void 0)return;const f=Math.max(0,Math.floor(c)),h=Math.min(g.length,Math.ceil(l));return h>f?Ya(i,g,f,h):new Uint8Array(0)},refusal:_t(i)?`This .2bit is read by range rather than held, so its sequences are not here whole to read. A FASTA under ${G.int(_A/1e6)} MB is held whole (\`twoBitToFa\`).`:`This FASTA is read by range from its index rather than held, so its sequences are not here whole to read. A FASTA under ${G.int(_A/1e6)} MB is held whole.`}:{contigs:i.contigs,bases:a=>_n(i,a)}}};return{outputs:await e(s),provenance:{task:t.task,taskVersion:0,params:t.params,framing:t.framing,app:[Jd,$d].filter(o=>o!=="").join(" "),createdAt:new Date().toISOString()},notes:n,ms:performance.now()-A}}async function zC(t,e){const n=xt(t),A=await n.read(64,0);if(OC(A))return{format:"hdf5",contigs:[],origin:"features",exact:!0};const s=Ja(A);if(s!==null){const h=await(s==="bigwig"?new Go({filehandle:xt(t)}):new vo({filehandle:xt(t)})).getHeader();return{format:s,contigs:Ss(h),origin:s,exact:!0}}if(He(A)){const f=await Ne(n,t),h=await Va(n,f??Number.MAX_SAFE_INTEGER);if(h!==null)return{format:"bam",contigs:h.refs.map(u=>({name:u.name,length:u.length})),origin:"bam",exact:!0}}if(yn(A))return{format:"fasta",contigs:(await Wa(t,n,e)).contigs,origin:"fasta",exact:!0};if(va(A))return{format:"twobit",contigs:(await Pa(t,n,e)).contigs,origin:"twobit",exact:!0};const r=await n.readFile({onProgress:e}),o=await as(r);if(yn(o))return{format:"fasta",contigs:Ls(t,o).contigs,origin:"fasta",exact:!0};const i=new TextDecoder().decode(o);if(i.trim()==="")throw new Error("This file is empty.");if(yh(i,t.name))return Mt={key:tt(t),format:"sizes",features:null},{format:"sizes",contigs:ph(i),origin:"sizes",exact:!0};if(Vo(i)){const f=ng(i);if(f.length>0)return{format:"vcf",contigs:f,origin:"vcf",exact:!0};const h=ti(i),u=new Map;for(let I=0;I<h.length;I++)lt(u,h.contigs[h.contig[I]],h.end[I]);return{format:"vcf",contigs:It(u),origin:"features",exact:!1}}if(hs(A)){const f=await Ha(n),h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"structure",contigs:It(h),origin:"features",exact:!1}}if(mA(i,t.name)||EA(i,t.name)||hi(i,t.name)){const f=mA(i,t.name)?Ei(i,t.name):EA(i,t.name)?di(i,t.name):Ci(i,t.name),h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"structure",contigs:It(h),origin:"features",exact:!1}}if(ii(i,t.name)){const f=li(i,t.name),h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"barchart",contigs:It(h),origin:"features",exact:!1}}if(ka(i)){const f=ba(i);Mt={key:tt(t),format:"cytoband",features:f};const h=CC(f);if(h!==null)return{format:"cytoband",contigs:h,origin:"cytoband",exact:!0};const u=new Map;for(let I=0;I<f.length;I++)lt(u,f.contigs[f.contig[I]],f.end[I]);return{format:"cytoband",contigs:It(u),origin:"features",exact:!1}}if(Ns(i,t.name)!==null){const f=Ra(i,t.name);Mt={key:tt(t),format:"junctions",features:f};const h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"junctions",contigs:It(h),origin:"features",exact:!1}}if(Ia(i,t.name)){const f=da(i);return{format:"interact",contigs:gA(f),origin:"features",exact:!1}}if(Qa(i,t.name)){const f=Ba(i);return{format:"longrange",contigs:gA(f),origin:"features",exact:!1}}if(wa(i,t.name)){const f=pa(i);Mt={key:tt(t),format:"genepred",features:f};const h=new Map;for(let u=0;u<f.length;u++)lt(h,f.contigs[f.contig[u]],f.end[u]);return{format:"genepred",contigs:It(h),origin:"features",exact:!1}}if(xa(i,t.name)){const{signal:f}=Ga(i),h=new Map;for(const u of f.contigs){let I=0;for(const d of u.ends)d>I&&(I=d);lt(h,u.name,I)}return{format:"bedmethyl",contigs:It(h),origin:"features",exact:!1}}const a=Di(i);if(a!==null){const f=a==="wig"?Fi(i):Mi(i);Mt={key:tt(t),format:a,features:null};const h=new Map;for(const u of f.contigs){let I=0;for(const d of u.ends)d>I&&(I=d);lt(h,u.name,I)}return{format:a,contigs:It(h),origin:"features",exact:!1}}const c=ei(i,t.name);if(c==="bedpe"){const f=oi(i);return Mt={key:tt(t),format:c,features:null},{format:c,contigs:gA(f),origin:"features",exact:!1}}const l=c==="gtf"?si(i):ls(i,t.name);Mt={key:tt(t),format:c,features:l};const g=new Map;for(let f=0;f<l.length;f++)lt(g,l.contigs[l.contig[f]],l.end[f]);return{format:c,contigs:It(g),origin:"features",exact:!1}}function Ss(t){return Object.values(t.refsByNumber).sort((e,n)=>e.id-n.id).map(e=>({name:e.name,length:e.length}))}function lt(t,e,n){const A=t.get(e);(A===void 0||n>A)&&t.set(e,n)}function gA(t){const e=new Map;for(let n=0;n<t.length;n++)lt(e,t.contigs[t.contig1[n]],t.end1[n]),lt(e,t.contigs[t.contig2[n]],t.end2[n]);return It(e)}function It(t){const e=[];for(const[n,A]of t){const s=10**Math.max(0,Math.floor(Math.log10(Math.max(1,A)))-2);e.push({name:n,length:(Math.floor(A/s)+1)*s})}return e}const Zt=new Map,XC=8;function xt(t){if(t.kind==="local")return new Ac(t.file);const{credential:e,headers:n}=t,A=`${t.url}|${e===void 0?"":JSON.stringify(e)}|${n===void 0?"":JSON.stringify(n)}`,s=Zt.get(A);if(s!==void 0)return Zt.delete(A),Zt.set(A,s),s;const r=e===void 0&&n===void 0?new Qr(t.url):new Qr(t.url,{fetch:(o,i)=>{const a=typeof o=="string"?o:o.url;return fetch(o,Gi(i,{url:a,...n===void 0?{}:{headers:n},...e===void 0?{}:{credential:e}}))}});for(Zt.set(A,r);Zt.size>XC;){const o=Zt.keys().next().value;Zt.delete(o)}return r}async function VC(t,e,n,A){const s=Rs(t);if(s===null||!He(n))return null;try{const r=await Ot(await xt(s).readFile()),o=ul(r),i=await Ne(e,t);if(i===null)return null;const a=Il(o,dl(o,Oa(A)),i);if(a.length===0||a.reduce((f,h)=>f+(h.to-h.from),0)>i*.8)return null;const l=[];for(const f of a){const h=await e.read(f.to-f.from,f.from),u=new TextDecoder().decode(await Ot(h,f.lastBlock-f.from));l.push(ZC(u,f.from===0,tQ(h,f,i)))}const g=l.join("");return g===""?null:g}catch{return null}}function ZC(t,e,n){let A=t;if(!e){const s=A.indexOf(`
+`);A=s<0?"":A.slice(s+1)}if(!n&&!A.endsWith(`
+`)){const s=A.lastIndexOf(`
+`);A=s<0?"":A.slice(0,s+1)}return A}const jC=28;function tQ(t,e,n){if(e.to<n)return!1;const A=e.lastBlock-e.from;if(A<0||A>=t.length)return!1;const s=pe(t.subarray(A,Math.min(A+64,t.length)));return s===null||A+s>t.length?!1:t.length-(A+s)<=jC}function Rs(t){return t.kind==="local"?t.index===void 0?null:{kind:"local",file:t.index,name:t.index.name}:t.index===void 0?null:{kind:"remote",url:t.index,name:t.index,...t.credential===void 0?{}:{credential:t.credential},...t.headers===void 0?{}:{headers:t.headers}}}async function Ne(t,e){const n=t.stat;if(typeof n=="function")try{const A=(await n.call(t)).size;if(Number.isFinite(A)&&A>0)return A}catch{}if(e===void 0||e.kind!=="remote")return null;try{const{credential:A,headers:s}=e,r=await fetch(e.url,Gi({method:"HEAD",mode:"cors"},{url:e.url,method:"HEAD",...s===void 0?{}:{headers:s},...A===void 0?{}:{credential:A}}));if(!r.ok)return null;const o=Number(r.headers.get("Content-Length")??Number.NaN);return Number.isFinite(o)&&o>0?o:null}catch{return null}}async function eQ(t,e,n,A){const s=xt(e),r=await s.read(64,0),o=Ja(r);if(o==="bigwig")return IQ(t,e,n);if(o==="bigbed")return uQ(t,e,n);if(He(r)){const I=await Ne(s,e),d=await Va(s,I??Number.MAX_SAFE_INTEGER);if(d!==null){if(I===null)throw new Error(`${e.name} cannot be measured — its host states neither Content-Range nor Content-Length to a page — and a BAM is read by byte range.`);return BQ(t,e,s,n,d,I,A)}}if(yn(r))return hA(t,await Wa(e,s,A),n);if(va(r))return hA(t,await Pa(e,s,A),n);if(hs(r))return iQ(s,n);const i=Mt;if(i!==null&&i.key===tt(e)&&i.features!==null)return Mt=null,WA(i.format,i.features,n);const a=await VC(e,s,r,n),c=a===null?await as(await s.readFile({onProgress:A})):null;if(c!==null&&yn(c))return hA(t,Ls(e,c),n);const l=a??new TextDecoder().decode(c);if(l.trim()==="")throw new Error("This file is empty.");if(Vo(l))return nQ(l,n);if(mA(l,e.name))return fA(l,e.name,n,Ei);if(EA(l,e.name))return fA(l,e.name,n);if(hi(l,e.name))return fA(l,e.name,n,Ci);if(ii(l,e.name))return qa(l,e.name,n);if(ka(l))return rQ(l,n);if(Ns(l,e.name)!==null)return oQ(l,e.name,n);if(Ia(l,e.name))return _a(l,n);if(Qa(l,e.name))return AQ(l,n);if(wa(l,e.name))return sQ(l,n);if(xa(l,e.name))return Ka(t,l,n);const f=Di(l);if(f!==null)return dQ(t,f,l,n);const h=ei(l,e.name);if(h==="bedpe"){const I=oi(l),d=ft(I.contigs,n);return{format:h,contigs:I.contigs,overlap:Z(I.contigs,n,d),summary:`${G.int(I.length)} pair${I.length===1?"":"s"}`,payload:{kind:"pairs",data:I}}}const u=h==="gtf"?si(l):ls(l,e.name);return WA(h,u,n)}function nQ(t,e){const n=ti(t),A=ft(n.contigs,e),s=tg(t);return{format:"vcf",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:`${G.int(n.length)} variant${n.length===1?"":"s"}`+(s===0?"":` · ${G.int(s)} sample${s===1?"":"s"} not drawn`),payload:{kind:"features",data:n}}}function _a(t,e){const n=da(t),A=ft(n.contigs,e);return{format:"interact",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:eC(n),payload:{kind:"pairs",data:n}}}function AQ(t,e){const n=Ba(t),A=ft(n.contigs,e);return{format:"longrange",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:sC(n),payload:{kind:"pairs",data:n}}}function sQ(t,e){const n=pa(t),A=ft(n.contigs,e);return{format:"genepred",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:ys(n),payload:{kind:"features",data:n}}}function Ka(t,e,n){const A=Ga(e),s=A.signal,r=we(s.contigs.map(a=>({name:a.name})),n);s.contigs.forEach((a,c)=>{a.name=r.names[c]});const o=new Si(s);Kn.set(t,o);const i=o.contigNames;return{format:"bedmethyl",contigs:i,overlap:Z(i,n,r),summary:FC(A),fileExtent:{min:0,max:100}}}function qa(t,e,n){const A=li(t,e),s=ft(A.contigs,n);return{format:"barchart",contigs:A.contigs,overlap:Z(A.contigs,n,s),summary:Gg(A),payload:{kind:"features",data:A}}}function rQ(t,e){const n=ba(t),A=ft(n.contigs,e);return{format:"cytoband",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:Da(n),payload:{kind:"features",data:n}}}function oQ(t,e,n){const A=Ra(t,e),s=ft(A.contigs,n);return{format:"junctions",contigs:A.contigs,overlap:Z(A.contigs,n,s),summary:La(A),payload:{kind:"features",data:A}}}function fA(t,e,n,A=di){const s=A(t,e),r=ft(s.contigs,n);return{format:"structure",contigs:s.contigs,overlap:Z(s.contigs,n,r),summary:Bi(s),payload:{kind:"features",data:s}}}async function Ha(t){const e=(o,i)=>t.read(o,i),n=await Ne(t),A=await Zg(e,n??void 0),s=Math.min(...A.resolutions),r=await jg(e,A,s);return Object.assign(r,{header:A})}async function iQ(t,e){const n=await Ha(t),A=ft(n.contigs,e),s=n.header.resolutions.filter(o=>o!==n.model?.width),r=[Bi(n),tf(n.header),...s.length===0?[]:[`also at ${s.join(", ")} bp`]].join(ct);return{format:"structure",contigs:n.contigs,overlap:Z(n.contigs,e,A),summary:r,payload:{kind:"features",data:n}}}function WA(t,e,n){const A=e.exonStart.length,s=ft(e.contigs,n);return{format:t,contigs:e.contigs,overlap:Z(e.contigs,n,s),summary:t==="gtf"?`${G.int(e.length)} transcripts · ${G.int(A)} exons`:t==="genepred"?ys(e):t==="cytoband"?Da(e):t==="junctions"?La(e):`${G.int(e.length)} feature${e.length===1?"":"s"}`,payload:{kind:"features",data:e}}}async function Wa(t,e,n){const A=oe;if(A!==null&&A.key===tt(t))return A.store;const s=t.kind==="local"?t.file.size:await Ne(e,t),r=s!==null&&s>0;if(r&&s<=_A)return mo(t,e,n);const o=await aQ(t,e);if(o!==null)return oe={key:tt(t),store:o},o;if(r&&s>Ms)throw za(s,t);return mo(t,e,n)}async function mo(t,e,n){return Ls(t,await as(await e.readFile({onProgress:n})))}async function aQ(t,e){const n=t.index!==void 0?t:t.kind==="remote"&&ua.test(t.url)?{...t,index:qd(t.url)}:null,A=n===null?null:Rs(n);if(A===null)return null;try{const s=Yd(new TextDecoder().decode(await xt(A).readFile()));return s.length===0?null:{indexed:!0,contigs:Od(s),records:new Map(s.map(r=>[r.name,r])),handle:e,total:s.reduce((r,o)=>r+o.length,0),held:new Map}}catch{return null}}async function Pa(t,e,n){const A=oe;if(A!==null&&A.key===tt(t)&&_t(A.store))return A.store;const s=await Ne(e),r=await JC((i,a)=>e.read(i,a,{onProgress:n}),s??void 0),o={twobit:!0,contigs:TC(r.ordered),records:r.records,handle:e,total:r.total,held:new Map};return oe={key:tt(t),store:o},o}function Ls(t,e){if(e.length>Ms)throw za(e.length,t);const n=Lf(e);if(n.contigs.length===0)throw new Error("This looks like a FASTA but holds no sequences.");return oe={key:tt(t),store:n},n}function za(t,e){const n=e.name.replace(/[#?].*$/,"")||"genome.fa";return new Error(`This FASTA is ${G.int(Math.round(t/1e6))} MB and has no index. It would be read whole and held whole — which is what makes panning free — so anything over ${G.int(Ms/1e6)} MB is refused rather than allowed to take the tab with it. Index it (\`samtools faidx ${n}\`) and ${e.kind==="local"?"drop the .fai with it":"publish the .fai beside it, or name it with #index=<url>"}: an indexed FASTA opens at once and is read by range.`)}function hA(t,e,n){const A=lQ(e,n);re.set(t,e);const s=e.contigs.map(r=>r.name);return{format:_t(e)?"twobit":"fasta",contigs:s,overlap:Z(s,n,A),summary:`${xs(s.length)} · ${G.bp(e.total)}`+(_t(e)?" · read by range, two bits a base":Ds(e)?" · read by range from its index":""),...me(e)?{byRange:{bases:e.total,bytesPerBase:cQ(e)}}:{}}}function cQ(t){if(_t(t))return .25;let e=0,n=0;for(const A of t.records.values())e+=A.length*A.lineWidth/A.lineBases,n+=A.length;return n>0?e/n:1}function lQ(t,e){const n=we(t.contigs,e);if(n.renamed===0)return n;if(_t(t)||Ds(t))return t.records=wo(t.records,t.contigs,n.names),t.held.clear(),n;const A=new Map;return t.contigs.forEach((s,r)=>{const o=t.bases.get(s.name);s.name=n.names[r],o!==void 0&&A.set(s.name,o)}),t.bases=A,n}function wo(t,e,n){const A=new Map;return e.forEach((s,r)=>{const o=t.get(s.name);s.name=n[r],o!==void 0&&A.set(s.name,{...o,name:s.name})}),A}async function gQ(t,e,n,A){const s=[];let r=Number.POSITIVE_INFINITY,o=Number.NEGATIVE_INFINITY;if(me(t)&&e.reduce((a,c)=>a+Math.max(0,c.end-c.start),0)>Eo)return{basesPerPixel:n,regions:[],extent:null,note:`GC under ${G.int(Eo/1e6)} Mb, letters at base resolution — zoom in`};for(const i of e){if(!(i.end>i.start))continue;let a;if(me(t)){const c=Math.max(0,Math.floor(i.start)),l=await $a(t,i.contig,c,i.end,A);if(l===void 0||l.length===0)continue;a=Ir(l,0,l.length,n);for(let g=0;g<a.starts.length;g++)a.starts[g]+=c,a.ends[g]+=c}else{const c=_n(t,i.contig);if(c===void 0)continue;a=Ir(c,i.start,i.end,n)}if(a.values.length!==0){for(const c of a.values)Number.isFinite(c)&&(c<r&&(r=c),c>o&&(o=c));s.push({contig:i.contig,start:i.start,end:i.end,starts:a.starts,ends:a.ends,values:a.values,min:null,max:null,variant:null,summary:!0})}}return{basesPerPixel:n,regions:s,extent:r<=o?{min:r,max:o}:null}}const fQ=4e5;async function hQ(t,e,n){const A=re.get(t);if(A===void 0)throw new Error("This sequence is no longer open. Drop the file again.");const s=[];let r=fQ;for(const o of e){const i=Math.max(0,Math.floor(o.start));if(me(A)){const l=await $a(A,o.contig,i,Math.min(Math.ceil(o.end),i+r),n);if(l===void 0||l.length===0)continue;if(r-=l.length,s.push({contig:o.contig,start:i,end:i+l.length,bases:l.slice()}),r<=0)break;continue}const a=_n(A,o.contig);if(a===void 0)continue;const c=Math.min(a.length,Math.ceil(o.end),i+r);if(c>i&&(r-=c-i,s.push({contig:o.contig,start:i,end:c,bases:a.slice(i,c)}),r<=0))break}return{regions:s}}const PA=1e6;async function uQ(t,e,n){const A=new vo({filehandle:xt(e)}),s=await A.getHeader(),r=Ss(s),o=[];let i=!1;for(const f of r){if(o.length>=PA){i=!0;break}const h=await A.getFeatures(f.name,0,f.length);for(const u of h){if(o.length>=PA){i=!0;break}const I=typeof u.rest=="string"&&u.rest!==""?`	${u.rest}`:"";o.push(`${f.name}	${u.start}	${u.end}${I}`)}}const a=o.join(`
+`),c=s.autoSql??"";if(xg(c)){const f=qa(a,e.name,n);return i?{...f,summary:Re(f.summary)}:f}if(tC(c)){const f=_a(a,n);return i?{...f,summary:Re(f.summary)}:f}if(MC(c)){const f=Ka(t,a,n);return i?{...f,summary:Re(f.summary)}:f}const l=ls(a,e.name);if(hC(c)){const f=ft(l.contigs,n),h={format:"genepred",contigs:l.contigs,overlap:Z(l.contigs,n,f),summary:ys(l),payload:{kind:"features",data:l}};return i?{...h,summary:Re(h.summary)}:h}const g=WA("bigbed",l,n);return{...g,summary:i?Re(g.summary):g.summary}}function Re(t){return`${t} · cut off at ${G.int(PA)}`}async function IQ(t,e,n){const A=new Go({filehandle:xt(e)}),s=await A.getHeader(),r=we(Ss(s),n),o=r.names;bs.set(t,{bigwig:A,refOf:r.sourceOf,refNames:Object.keys(s.refsByName)});const i=s.totalSummary,a=i!==void 0&&Number.isFinite(i.scoreMin)&&Number.isFinite(i.scoreMax)&&i.scoreMax>i.scoreMin;return{format:"bigwig",contigs:o,overlap:Z(o,n,r),summary:xs(o.length)+(a?` · ${ie(i.scoreMin)}–${ie(i.scoreMax)}`:""),...a?{fileExtent:{min:i.scoreMin,max:i.scoreMax}}:{}}}function dQ(t,e,n,A){const s=e==="wig"?Fi(n):Mi(n);if(s.length===0)throw new Error(`This looks like a ${e==="wig"?"wig":"bedGraph"} but holds no usable intervals.`);const r=we(s.contigs.map(g=>({name:g.name})),A);s.contigs.forEach((g,f)=>{g.name=r.names[f]});const o=new Si(s);Kn.set(t,o);const i=o.contigNames,{min:a,max:c}=o.extent,l=Number.isFinite(a)&&Number.isFinite(c)&&c>a;return{format:e,contigs:i,overlap:Z(i,A,r),summary:`${G.int(o.length)} intervals · ${xs(i.length)}`+(l?` · ${ie(a)}–${ie(c)}`:""),...l?{fileExtent:{min:a,max:c}}:{}}}function CQ(t,e,n){const A=[];let s=Number.POSITIVE_INFINITY,r=Number.NEGATIVE_INFINITY;for(const o of e){if(!t.has(o.contig)||o.end<=o.start)continue;const i=t.samples(o.contig,o.start,o.end,n);if(i!==null){for(const a of i.values)Number.isFinite(a)&&(a<s&&(s=a),a>r&&(r=a));A.push({contig:o.contig,start:o.start,end:o.end,variant:null,...i})}}return{basesPerPixel:n,regions:A,extent:s<=r?{min:s,max:r}:null}}async function Xa(t,e,n,A,s,r=!1){const o=qn.get(t);if(o!==void 0)return NQ(s,o,e,n,A);const i=re.get(t);if(i!==void 0)return gQ(i,e,n,dn(s));const a=Kn.get(t);if(a!==void 0)return CQ(a,e,n);const c=OA.get(t);if(c!==void 0)return Dh(c,e,n,r);const l=bs.get(t);if(l===void 0)throw new Error("This track is no longer open. Drop the file again.");const g=C=>{const E=l.refOf.get(C);if(E!==void 0)return E;const B=Kt(l.refNames,C);if(!(B<0))return l.refOf.set(C,l.refNames[B]),l.refNames[B]},f=e.filter(C=>g(C.contig)!==void 0&&C.end>C.start);if(f.length===0)return{basesPerPixel:n,regions:[],extent:null};const h=await l.bigwig.getFeaturesAsArraysMulti(f.map(C=>({refName:g(C.contig)??C.contig,start:Math.max(0,Math.floor(C.start)),end:Math.ceil(C.end)})),{basesPerSpan:Math.max(1,n)}),u=[];let I=Number.POSITIVE_INFINITY,d=Number.NEGATIVE_INFINITY;for(let C=0;C<f.length;C++){const E=h.regionOffsets[C],B=h.regionOffsets[C+1],Q=h.scores.slice(E,B);for(let m=0;m<Q.length;m++){const p=Q[m];Number.isFinite(p)&&(p<I&&(I=p),p>d&&(d=p))}u.push({contig:f[C].contig,start:f[C].start,end:f[C].end,starts:h.starts.slice(E,B),ends:h.ends.slice(E,B),values:Q,min:h.isSummary?h.minScores.slice(E,B):null,max:h.isSummary?h.maxScores.slice(E,B):null,variant:null,summary:h.isSummary})}return{basesPerPixel:n,regions:u,extent:I<=d?{min:I,max:d}:null}}const QQ=1<<18,po=1<<24;async function Va(t,e){const n=Number.isFinite(e)&&e>0?e:Number.MAX_SAFE_INTEGER;let A=QQ;for(;;){let s;try{s=await Ot(await t.read(Math.min(A,n),0))}catch{return null}if(!Po(s))return null;const r=Nl(s);if(r!==null)return r;if(A>=n||A>=po)throw new Error("This BAM's header is truncated: its reference table does not end.");A=Math.min(A*4,po)}}async function BQ(t,e,n,A,s,r,o){if(s.sortOrder==="queryname"||s.sortOrder==="unsorted")throw new Error(`${e.name} is sorted by ${s.sortOrder==="queryname"?"read name":"nothing"}, and reads are drawn by region. Run \`samtools sort -o sorted.bam ${e.name}\` and index the result.`);const i=Rs(e),a=i===null?`${tt(e)}|search`:KC(e,i),c=Gn.get(a);let l=null,g=null,f="";if(c!==void 0)l=c.open.index,g=c.open.search,f=c.open.searched;else{if(i===null)f="no index dropped with it";else try{l=await hf(await xt(i).readFile({onProgress:o}))}catch(C){const E=C instanceof Error?C.message:String(C);f=i.kind==="remote"?`no ${i.url.split("?")[0].split("/").pop()??"index"} beside it`:`${i.name} could not be read (${E})`}if(l===null){if(!Number.isFinite(r)||r<=0)throw new Error(`${e.name} has ${f}, and its length could not be learnt, so its reads cannot be located by search either. A BAM is read by region: publish its index beside it, or name one with \`${e.kind==="remote"?e.url:e.name}#index=<url of the .bai>\`.`);try{g=await us.open(n,r,s,C=>o(C,0))}catch(C){if(C instanceof wA)throw new Error(EQ(e.name,s,C));const E=C instanceof Error?C.message:String(C);throw new Error(`${e.name} has ${f} and could not be read by search: ${E}. A BAM is read by region; run \`samtools index ${e.name}\` and publish the index beside it, or name one with \`#index=<url of the .bai>\`.`)}}}const h=we(s.refs,A),u=h.names,I=new Map;for(let C=0;C<u.length;C++)I.set(u[C],C);for(let C=0;C<s.refs.length;C++)I.has(s.refs[C].name)||I.set(s.refs[C].name,C);const d=c?.open??{handle:n,header:s,index:l,search:g,searched:f,size:r,refIdOf:I,refNames:s.refs.map(C=>C.name)};return c===void 0?Gn.set(a,{open:d,holders:new Set([t])}):c.holders.add(t),qn.set(t,d),{format:"bam",contigs:u,overlap:Z(u,A,h),summary:`${G.int(s.refs.length)} reference${s.refs.length===1?"":"s"} · ${l!==null?l.format.toUpperCase():`${f} — reads located by search`}`}}function EQ(t,e,n){const A=e.sortOrder==="coordinate"?"its header says SO:coordinate, but":"its header has no @HD line to say so, and";return`${t} is not in coordinate order — ${A} the reads at byte ${G.int(n.before.block)} are on ${fr(n.before,e.refs)} while those at byte ${G.int(n.after.block)}, later in the file, are on ${fr(n.after,e.refs)}. Reads are drawn by region, which needs the file sorted and indexed: run \`samtools sort -o sorted.bam ${t}\` and \`samtools index sorted.bam\`. The alignment file a Hi-C pipeline writes is in read-pair order for its pairs step and is not made for browsing; its .pairs or its contact map is the file to open.`}const mQ=4e6;function wQ(t,e){if(t.search===null)return null;const n=e.reduce((A,s)=>A+(s.end-s.start),0);return e.length>1||n>mQ?`${pQ(n)} without an index — zoom in`:null}function pQ(t){return t>=1e6?`${ie(t/1e6)} Mb`:`${ie(t/1e3)} kb`}async function Za(t,e,n,A,s){const r=Math.max(0,Math.floor(n.start)),o=Math.ceil(n.end);return t.index!==null?Ef(t.index,e,r,o,t.size):t.search===null?[]:t.search.spansFor(e,r,o,async()=>{if(!await Fs(A))throw Pe()},s)}function ja(t){return t===void 0?ki:{exclude:Wo|(t.hideDuplicates?At.DUPLICATE:0),minMapq:t.minMapq}}function yQ(t){const e=ja(t);return t.splits?{...e,exclude:e.exclude&-2049}:e}async function NQ(t,e,n,A,s){const r=I=>{const d=e.refIdOf.get(I);if(d!==void 0)return d;const C=Kt(e.refNames,I);if(!(C<0))return e.refIdOf.set(I,C),C},o=n.filter(I=>r(I.contig)!==void 0&&I.end>I.start);if(o.length===0)return{basesPerPixel:A,regions:[],extent:null};const i=wQ(e,o);if(i!==null)return{basesPerPixel:A,regions:[],extent:null,note:i};const a=[];for(const I of o){const d=r(I.contig);a.push({region:I,refId:d,spans:await Za(e,d,I,t,Bo)})}const c=a.reduce((I,d)=>I+yi(d.spans),0);if(c>Bo)return{basesPerPixel:A,regions:[],extent:null,note:`${G.bytes(c)} of reads — zoom in`};const l=[];let g=Number.POSITIVE_INFINITY,f=Number.NEGATIVE_INFINITY;const h=s?.modFraction===!0,u=[];for(const I of a){const d=I.region.end-I.region.start,C=Math.max(1,Math.min(4096,Math.round(d/Math.max(1,A)))),E=new Float64Array(C),B=new Map;u.push(B);const Q=A<=RQ?tc(I.region):void 0,m=Q===void 0?null:new Float64Array(C),p=new Map;for(const D of I.spans){if(!await Fs(t))throw Pe();const F=await e.handle.read(D.to-D.from,D.from),R=await Ot(F,D.lastBlock-D.from),v=Uf(R,D.dataFrom,I.refId,Math.floor(I.region.start),Math.ceil(I.region.end),C,ja(s),Q,p,h?{tally:B,threshold:s.modThreshold}:void 0);for(let x=0;x<C;x++)E[x]+=v.depth[x];if(m!==null&&v.variant!==null)for(let x=0;x<C;x++)m[x]+=v.variant[x]}const w=new Int32Array(C),y=new Int32Array(C),N=new Float32Array(C),k=m===null?null:new Float32Array(C),b=d/C;for(let D=0;D<C;D++)w[D]=Math.round(I.region.start+D*b),y[D]=Math.round(I.region.start+(D+1)*b),N[D]=E[D],k!==null&&m!==null&&(k[D]=m[D]),E[D]<g&&(g=E[D]),E[D]>f&&(f=E[D]);l.push({contig:I.region.contig,start:I.region.start,end:I.region.end,starts:w,ends:y,values:N,variant:k,junctions:bQ(p),min:null,max:null,summary:!1})}return h?kQ(A,l,u,s.modCode):{basesPerPixel:A,regions:l,extent:g<=f&&f>0?{min:0,max:f}:null}}function kQ(t,e,n,A){const s=new Map;for(const c of n)for(const[l,g]of c){const f=s.get(l)??[0,0];f[0]+=g.modified.reduce((h,u)=>h+u,0),f[1]+=g.calls.reduce((h,u)=>h+u,0),s.set(l,f)}const r=[...s.entries()].sort((c,l)=>l[1][0]-c[1][0]||l[1][1]-c[1][1]).map(([c])=>c),o=A!==""?A:r[0]??"";let i=!1;const a=e.map((c,l)=>{const g=n[l].get(o),f=new Float32Array(c.values.length).fill(Number.NaN);if(g!==void 0)for(let h=0;h<f.length;h++)g.calls[h]<=0||(f[h]=100*g.modified[h]/g.calls[h],i=!0);return{...c,values:f,variant:null,junctions:void 0}});return{basesPerPixel:t,regions:a,extent:i?{min:0,max:100}:null,mods:{code:o,codes:r},...r.length===0?{note:"no MM/ML modification calls here"}:{}}}function bQ(t){const e=[];for(const[s,r]of t){const[o,i,a]=s.split(":").map(Number);e.push([o,i,a,r])}e.sort((s,r)=>s[0]-r[0]||s[1]-r[1]||s[2]-r[2]);const n=e.length,A={starts:new Int32Array(n),ends:new Int32Array(n),counts:new Float32Array(n),strands:new Int8Array(n)};return e.forEach(([s,r,o,i],a)=>{A.starts[a]=s,A.ends[a]=r,A.strands[a]=o,A.counts[a]=i}),A}const yo=4<<20,DQ=2e5,MQ=40;async function FQ(t,e,n,A,s,r){const o=qn.get(t);if(o===void 0)throw new Error("This track is no longer open. Drop the file again.");const i={piles:[],total:0,kept:0,capped:!1,rows:0,diffs:"none"},a=m=>{const p=o.refIdOf.get(m);if(p!==void 0)return p;const w=Kt(o.refNames,m);if(!(w<0))return o.refIdOf.set(m,w),w},c=e.filter(m=>a(m.contig)!==void 0&&m.end>m.start);if(c.length===0)return i;const l=c.reduce((m,p)=>m+(p.end-p.start),0);if(l>DQ)return{...i,note:`${ie(l/1e3)} kb — too wide to draw reads`};const g=[];for(const m of c){const p=a(m.contig);g.push({region:m,refId:p,spans:await Za(o,p,m,r,yo)})}const f=g.reduce((m,p)=>m+yi(p.spans),0);if(f>yo)return{...i,note:`${G.bytes(f)} of reads here — zoom in`};const h=[];let u=0,I=0,d=!1,C=0,E=!1,B=!1,Q=!1;for(const m of g){const p=tc(m.region);p!==void 0&&(Q=!0);for(const w of m.spans){if(!await Fs(r))throw Pe();const y=await o.handle.read(w.to-w.from,w.from),N=await Ot(y,w.lastBlock-w.from),k=_f(N,w.dataFrom,m.region.contig,m.refId,Math.floor(m.region.start),Math.ceil(m.region.end),{filter:yQ(s),maxRows:n,maxReads:SQ,colourBy:s.colourBy,withNames:A<=MQ,refNameOf:b=>o.refNames[b],...p===void 0?{}:{reference:p}});u+=k.total,I+=k.kept,d=d||k.capped,C=Math.max(C,k.rows),E=E||k.usedMd,B=B||k.usedCigar,(k.pile.length>0||h.length===0)&&h.push(k.pile)}}return{piles:h,total:u,kept:I,capped:d,rows:C,diffs:B?"cigar":E?"md":Q?"reference":"none"}}const SQ=2e4,RQ=16;function tc(t){const e=Math.max(0,Math.floor(t.start));for(const n of re.values()){if(me(n)){const r=ks(n,t.contig),o=r===void 0?void 0:n.held.get(r.name);if(o===void 0)continue;const i=Math.min(o.start+o.bases.length,Math.ceil(t.end));if(o.start>e||i<=e)continue;return{start:e,bases:o.bases.subarray(e-o.start,i-o.start)}}const A=_n(n,t.contig);if(A===void 0)continue;const s=Math.min(A.length,Math.ceil(t.end));if(!(s<=e))return{start:e,bases:A.subarray(e,s)}}}function xs(t){return`${G.int(t)} sequence${t===1?"":"s"}`}function ie(t){if(!Number.isFinite(t))return"—";const e=Math.abs(t);return e===0?"0":e>=1e3?G.int(Math.round(t)):e>=1?t.toFixed(2).replace(/\.?0+$/,""):t.toPrecision(2)}