boltz-api 0.44.1 → 0.45.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/CHANGELOG.md +8 -0
- package/client.d.mts +2 -2
- package/client.d.ts +2 -2
- package/client.js +2 -2
- package/client.mjs +2 -2
- package/package.json +1 -1
- package/resources/admin/workspaces.d.mts +1 -1
- package/resources/admin/workspaces.d.ts +1 -1
- package/resources/admin/workspaces.js +1 -1
- package/resources/admin/workspaces.mjs +1 -1
- package/resources/protein/design.d.mts +87 -50
- package/resources/protein/design.d.mts.map +1 -1
- package/resources/protein/design.d.ts +87 -50
- package/resources/protein/design.d.ts.map +1 -1
- package/resources/protein/library-screen.d.mts +62 -30
- package/resources/protein/library-screen.d.mts.map +1 -1
- package/resources/protein/library-screen.d.ts +62 -30
- package/resources/protein/library-screen.d.ts.map +1 -1
- package/resources/protein/protein.d.mts +1 -1
- package/resources/protein/protein.d.ts +1 -1
- package/resources/protein/protein.js +1 -1
- package/resources/protein/protein.mjs +1 -1
- package/resources/small-molecule/design.d.mts +52 -20
- package/resources/small-molecule/design.d.mts.map +1 -1
- package/resources/small-molecule/design.d.ts +52 -20
- package/resources/small-molecule/design.d.ts.map +1 -1
- package/resources/small-molecule/library-screen.d.mts +52 -20
- package/resources/small-molecule/library-screen.d.mts.map +1 -1
- package/resources/small-molecule/library-screen.d.ts +52 -20
- package/resources/small-molecule/library-screen.d.ts.map +1 -1
- package/resources/small-molecule/small-molecule.d.mts +1 -1
- package/resources/small-molecule/small-molecule.d.ts +1 -1
- package/resources/small-molecule/small-molecule.js +1 -1
- package/resources/small-molecule/small-molecule.mjs +1 -1
- package/src/client.ts +2 -2
- package/src/resources/admin/workspaces.ts +1 -1
- package/src/resources/protein/design.ts +95 -50
- package/src/resources/protein/library-screen.ts +70 -30
- package/src/resources/protein/protein.ts +1 -1
- package/src/resources/small-molecule/design.ts +60 -20
- package/src/resources/small-molecule/library-screen.ts +60 -20
- package/src/resources/small-molecule/small-molecule.ts +1 -1
- package/src/version.ts +1 -1
- package/version.d.mts +1 -1
- package/version.d.ts +1 -1
- package/version.js +1 -1
- package/version.mjs +1 -1
package/CHANGELOG.md
CHANGED
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@@ -1,5 +1,13 @@
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# Changelog
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## 0.45.0 (2026-06-15)
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Full Changelog: [v0.44.1...v0.45.0](https://github.com/boltz-bio/boltz-api-typescript/compare/v0.44.1...v0.45.0)
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### Features
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* **compute-api:** rename public pipeline identifiers ([d19af6e](https://github.com/boltz-bio/boltz-api-typescript/commit/d19af6e265bd696e125744104a3537a0aae7d358))
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## 0.44.1 (2026-06-15)
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Full Changelog: [v0.44.0...v0.44.1](https://github.com/boltz-bio/boltz-api-typescript/compare/v0.44.0...v0.44.1)
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package/client.d.mts
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@@ -183,11 +183,11 @@ export declare class Boltz {
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*/
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predictions: API.Predictions;
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/**
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* Small Molecule
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* Small Molecule Pipeline — design novel small molecules and screen compound libraries against protein targets. Includes de novo generation and virtual screening.
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*/
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smallMolecule: API.SmallMolecule;
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/**
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* Protein
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* Protein Pipeline — design novel protein binders and screen protein libraries against targets. Includes de novo protein design and library screening.
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*/
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protein: API.Protein;
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/**
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package/client.d.ts
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*/
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predictions: API.Predictions;
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/**
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* Small Molecule
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* Small Molecule Pipeline — design novel small molecules and screen compound libraries against protein targets. Includes de novo generation and virtual screening.
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*/
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smallMolecule: API.SmallMolecule;
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/**
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* Protein
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* Protein Pipeline — design novel protein binders and screen protein libraries against targets. Includes de novo protein design and library screening.
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*/
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protein: API.Protein;
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/**
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package/client.js
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*/
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this.predictions = new API.Predictions(this);
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/**
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* Small Molecule
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* Small Molecule Pipeline — design novel small molecules and screen compound libraries against protein targets. Includes de novo generation and virtual screening.
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*/
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this.smallMolecule = new API.SmallMolecule(this);
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/**
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* Protein
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* Protein Pipeline — design novel protein binders and screen protein libraries against targets. Includes de novo protein design and library screening.
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*/
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this.protein = new API.Protein(this);
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package/client.mjs
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*/
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this.predictions = new API.Predictions(this);
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/**
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* Small Molecule
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* Small Molecule Pipeline — design novel small molecules and screen compound libraries against protein targets. Includes de novo generation and virtual screening.
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*/
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this.smallMolecule = new API.SmallMolecule(this);
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/**
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* Protein
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* Protein Pipeline — design novel protein binders and screen protein libraries against targets. Includes de novo protein design and library screening.
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*/
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this.protein = new API.Protein(this);
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/**
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package/package.json
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@@ -3,7 +3,7 @@ import { APIPromise } from "../../core/api-promise.mjs";
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import { CursorPage, type CursorPageParams, PagePromise } from "../../core/pagination.mjs";
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import { RequestOptions } from "../../internal/request-options.mjs";
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/**
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* Workspaces provide isolated environments for organizing predictions and
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* Workspaces provide isolated environments for organizing predictions and pipeline runs across teams, projects, or customers. Each workspace has independent data retention settings and can be associated with workspace API keys.
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*/
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export declare class Workspaces extends APIResource {
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/**
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import { CursorPage, type CursorPageParams, PagePromise } from "../../core/pagination.js";
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import { RequestOptions } from "../../internal/request-options.js";
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/**
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* Workspaces provide isolated environments for organizing predictions and
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* Workspaces provide isolated environments for organizing predictions and pipeline runs across teams, projects, or customers. Each workspace has independent data retention settings and can be associated with workspace API keys.
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export declare class Workspaces extends APIResource {
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/**
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const pagination_1 = require("../../core/pagination.js");
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const path_1 = require("../../internal/utils/path.js");
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/**
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* Workspaces provide isolated environments for organizing predictions and
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* Workspaces provide isolated environments for organizing predictions and pipeline runs across teams, projects, or customers. Each workspace has independent data retention settings and can be associated with workspace API keys.
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class Workspaces extends resource_1.APIResource {
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/**
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import { CursorPage } from "../../core/pagination.mjs";
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import { path } from "../../internal/utils/path.mjs";
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/**
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* Workspaces provide isolated environments for organizing predictions and
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* Workspaces provide isolated environments for organizing predictions and pipeline runs across teams, projects, or customers. Each workspace has independent data retention settings and can be associated with workspace API keys.
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export class Workspaces extends APIResource {
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/**
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export type DesignListResponsesCursorPage = CursorPage<DesignListResponse>;
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export type DesignListResultsResponsesCursorPage = CursorPage<DesignListResultsResponse>;
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/**
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* A protein design
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* A protein design pipeline run that generates novel protein binders
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*/
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export interface DesignRetrieveResponse {
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/**
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*/
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data_deleted_at: string | null;
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/**
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*
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* @deprecated Use pipeline instead.
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*/
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engine: '
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engine: 'boltzprot';
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/**
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*
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* @deprecated Use pipeline_version instead.
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*/
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engine_version: '1.0';
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error: DesignRetrieveResponse.Error | null;
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/**
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* Pipeline input (null if data deleted)
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* Whether this resource was created with a live API key.
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*/
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livemode: boolean;
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/**
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* Pipeline used for protein design
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*/
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pipeline: 'boltzprot';
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/**
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* Pipeline version used for protein design
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*/
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pipeline_version: '1.0';
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progress: DesignRetrieveResponse.Progress | null;
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status: 'pending' | 'running' | 'succeeded' | 'failed' | 'stopped';
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* Binder specification starting from an existing 3D structure. Upload a CIF/PDB
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* file and select which chains to include, which residues to keep, and which
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* regions to redesign. Only chains included in chain_selection are part of the
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*
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* pipeline run.
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interface StructureTemplateBinderSpecResponse {
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/**
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* Chains selected from the uploaded binder structure, keyed by chain ID. Only
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* chains listed here are included in the pipeline run — any chains omitted from
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* this mapping are ignored. Each value defines which residues to keep
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* (crop_residues). Omit design_motifs to include the chain as fixed scaffold
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* context.
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chain_selection: {
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[key: string]: StructureTemplateBinderSpecResponse.StructureTemplatePolymerChainSpec | StructureTemplateBinderSpecResponse.StructureTemplateLigandChainSpec;
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interface StructureTemplateTargetResponse {
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* epitope residues, which are non-binding residues, and which are flexible.
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* residues. Residues not listed are excluded from the pipeline run.
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}
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/**
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* Summary of a protein design
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* Summary of a protein design pipeline run (excludes input)
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interface StructureTemplateBinderSpecResponse {
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|
/**
|
|
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|
* Chains selected from the uploaded binder structure, keyed by chain ID. Only
|
|
1658
|
-
* chains listed here are included in the
|
|
1659
|
-
* mapping are ignored. Each value defines which residues to keep
|
|
1660
|
-
* Omit design_motifs to include the chain as fixed scaffold
|
|
1683
|
+
* chains listed here are included in the pipeline run — any chains omitted from
|
|
1684
|
+
* this mapping are ignored. Each value defines which residues to keep
|
|
1685
|
+
* (crop_residues). Omit design_motifs to include the chain as fixed scaffold
|
|
1686
|
+
* context.
|
|
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|
*/
|
|
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|
chain_selection: {
|
|
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|
[key: string]: StructureTemplateBinderSpecResponse.StructureTemplatePolymerChainSpec | StructureTemplateBinderSpecResponse.StructureTemplateLigandChainSpec;
|
|
@@ -2170,7 +2196,7 @@ export declare namespace DesignStartResponse {
|
|
|
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|
interface StructureTemplateTargetResponse {
|
|
2171
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|
/**
|
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|
* Chains selected from the uploaded structure, keyed by chain ID. Only chains
|
|
2173
|
-
* listed here are included in the
|
|
2199
|
+
* listed here are included in the pipeline run — any chains omitted from this
|
|
2174
2200
|
* mapping are ignored. Each value defines which residues to keep, which are
|
|
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|
* epitope residues, which are non-binding residues, and which are flexible.
|
|
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|
*/
|
|
@@ -2189,7 +2215,7 @@ export declare namespace DesignStartResponse {
|
|
|
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|
chain_type: 'polymer';
|
|
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2216
|
/**
|
|
2191
2217
|
* 0-indexed residue indices to retain from this chain, or 'all' to keep all
|
|
2192
|
-
* residues. Residues not listed are excluded from the
|
|
2218
|
+
* residues. Residues not listed are excluded from the pipeline run.
|
|
2193
2219
|
*/
|
|
2194
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|
crop_residues: Array<number> | 'all';
|
|
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|
/**
|
|
@@ -2620,7 +2646,7 @@ export declare namespace DesignStartResponse {
|
|
|
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|
}
|
|
2621
2647
|
}
|
|
2622
2648
|
/**
|
|
2623
|
-
* A protein design
|
|
2649
|
+
* A protein design pipeline run that generates novel protein binders
|
|
2624
2650
|
*/
|
|
2625
2651
|
export interface DesignStopResponse {
|
|
2626
2652
|
/**
|
|
@@ -2635,13 +2661,13 @@ export interface DesignStopResponse {
|
|
|
2635
2661
|
*/
|
|
2636
2662
|
data_deleted_at: string | null;
|
|
2637
2663
|
/**
|
|
2638
|
-
*
|
|
2664
|
+
* @deprecated Use pipeline instead.
|
|
2639
2665
|
*/
|
|
2640
|
-
engine: '
|
|
2666
|
+
engine: 'boltzprot';
|
|
2641
2667
|
/**
|
|
2642
|
-
*
|
|
2668
|
+
* @deprecated Use pipeline_version instead.
|
|
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|
*/
|
|
2644
|
-
engine_version:
|
|
2670
|
+
engine_version: '1.0';
|
|
2645
2671
|
error: DesignStopResponse.Error | null;
|
|
2646
2672
|
/**
|
|
2647
2673
|
* Pipeline input (null if data deleted)
|
|
@@ -2651,6 +2677,14 @@ export interface DesignStopResponse {
|
|
|
2651
2677
|
* Whether this resource was created with a live API key.
|
|
2652
2678
|
*/
|
|
2653
2679
|
livemode: boolean;
|
|
2680
|
+
/**
|
|
2681
|
+
* Pipeline used for protein design
|
|
2682
|
+
*/
|
|
2683
|
+
pipeline: 'boltzprot';
|
|
2684
|
+
/**
|
|
2685
|
+
* Pipeline version used for protein design
|
|
2686
|
+
*/
|
|
2687
|
+
pipeline_version: '1.0';
|
|
2654
2688
|
progress: DesignStopResponse.Progress | null;
|
|
2655
2689
|
started_at: string | null;
|
|
2656
2690
|
status: 'pending' | 'running' | 'succeeded' | 'failed' | 'stopped';
|
|
@@ -2711,14 +2745,15 @@ export declare namespace DesignStopResponse {
|
|
|
2711
2745
|
* Binder specification starting from an existing 3D structure. Upload a CIF/PDB
|
|
2712
2746
|
* file and select which chains to include, which residues to keep, and which
|
|
2713
2747
|
* regions to redesign. Only chains included in chain_selection are part of the
|
|
2714
|
-
*
|
|
2748
|
+
* pipeline run.
|
|
2715
2749
|
*/
|
|
2716
2750
|
interface StructureTemplateBinderSpecResponse {
|
|
2717
2751
|
/**
|
|
2718
2752
|
* Chains selected from the uploaded binder structure, keyed by chain ID. Only
|
|
2719
|
-
* chains listed here are included in the
|
|
2720
|
-
* mapping are ignored. Each value defines which residues to keep
|
|
2721
|
-
* Omit design_motifs to include the chain as fixed scaffold
|
|
2753
|
+
* chains listed here are included in the pipeline run — any chains omitted from
|
|
2754
|
+
* this mapping are ignored. Each value defines which residues to keep
|
|
2755
|
+
* (crop_residues). Omit design_motifs to include the chain as fixed scaffold
|
|
2756
|
+
* context.
|
|
2722
2757
|
*/
|
|
2723
2758
|
chain_selection: {
|
|
2724
2759
|
[key: string]: StructureTemplateBinderSpecResponse.StructureTemplatePolymerChainSpec | StructureTemplateBinderSpecResponse.StructureTemplateLigandChainSpec;
|
|
@@ -3231,7 +3266,7 @@ export declare namespace DesignStopResponse {
|
|
|
3231
3266
|
interface StructureTemplateTargetResponse {
|
|
3232
3267
|
/**
|
|
3233
3268
|
* Chains selected from the uploaded structure, keyed by chain ID. Only chains
|
|
3234
|
-
* listed here are included in the
|
|
3269
|
+
* listed here are included in the pipeline run — any chains omitted from this
|
|
3235
3270
|
* mapping are ignored. Each value defines which residues to keep, which are
|
|
3236
3271
|
* epitope residues, which are non-binding residues, and which are flexible.
|
|
3237
3272
|
*/
|
|
@@ -3250,7 +3285,7 @@ export declare namespace DesignStopResponse {
|
|
|
3250
3285
|
chain_type: 'polymer';
|
|
3251
3286
|
/**
|
|
3252
3287
|
* 0-indexed residue indices to retain from this chain, or 'all' to keep all
|
|
3253
|
-
* residues. Residues not listed are excluded from the
|
|
3288
|
+
* residues. Residues not listed are excluded from the pipeline run.
|
|
3254
3289
|
*/
|
|
3255
3290
|
crop_residues: Array<number> | 'all';
|
|
3256
3291
|
/**
|
|
@@ -3724,14 +3759,15 @@ export declare namespace DesignEstimateCostParams {
|
|
|
3724
3759
|
* Binder specification starting from an existing 3D structure. Upload a CIF/PDB
|
|
3725
3760
|
* file and select which chains to include, which residues to keep, and which
|
|
3726
3761
|
* regions to redesign. Only chains included in chain_selection are part of the
|
|
3727
|
-
*
|
|
3762
|
+
* pipeline run.
|
|
3728
3763
|
*/
|
|
3729
3764
|
interface StructureTemplateBinderSpec {
|
|
3730
3765
|
/**
|
|
3731
3766
|
* Chains selected from the uploaded binder structure, keyed by chain ID. Only
|
|
3732
|
-
* chains listed here are included in the
|
|
3733
|
-
* mapping are ignored. Each value defines which residues to keep
|
|
3734
|
-
* Omit design_motifs to include the chain as fixed scaffold
|
|
3767
|
+
* chains listed here are included in the pipeline run — any chains omitted from
|
|
3768
|
+
* this mapping are ignored. Each value defines which residues to keep
|
|
3769
|
+
* (crop_residues). Omit design_motifs to include the chain as fixed scaffold
|
|
3770
|
+
* context.
|
|
3735
3771
|
*/
|
|
3736
3772
|
chain_selection: {
|
|
3737
3773
|
[key: string]: StructureTemplateBinderSpec.StructureTemplatePolymerChainSpec | StructureTemplateBinderSpec.StructureTemplateLigandChainSpec;
|
|
@@ -4253,7 +4289,7 @@ export declare namespace DesignEstimateCostParams {
|
|
|
4253
4289
|
interface StructureTemplateTarget {
|
|
4254
4290
|
/**
|
|
4255
4291
|
* Chains selected from the uploaded structure, keyed by chain ID. Only chains
|
|
4256
|
-
* listed here are included in the
|
|
4292
|
+
* listed here are included in the pipeline run — any chains omitted from this
|
|
4257
4293
|
* mapping are ignored. Each value defines which residues to keep, which are
|
|
4258
4294
|
* epitope residues, which are non-binding residues, and which are flexible.
|
|
4259
4295
|
*/
|
|
@@ -4276,7 +4312,7 @@ export declare namespace DesignEstimateCostParams {
|
|
|
4276
4312
|
chain_type: 'polymer';
|
|
4277
4313
|
/**
|
|
4278
4314
|
* 0-indexed residue indices to retain from this chain, or 'all' to keep all
|
|
4279
|
-
* residues. Residues not listed are excluded from the
|
|
4315
|
+
* residues. Residues not listed are excluded from the pipeline run.
|
|
4280
4316
|
*/
|
|
4281
4317
|
crop_residues: Array<number> | 'all';
|
|
4282
4318
|
/**
|
|
@@ -4732,14 +4768,15 @@ export declare namespace DesignStartParams {
|
|
|
4732
4768
|
* Binder specification starting from an existing 3D structure. Upload a CIF/PDB
|
|
4733
4769
|
* file and select which chains to include, which residues to keep, and which
|
|
4734
4770
|
* regions to redesign. Only chains included in chain_selection are part of the
|
|
4735
|
-
*
|
|
4771
|
+
* pipeline run.
|
|
4736
4772
|
*/
|
|
4737
4773
|
interface StructureTemplateBinderSpec {
|
|
4738
4774
|
/**
|
|
4739
4775
|
* Chains selected from the uploaded binder structure, keyed by chain ID. Only
|
|
4740
|
-
* chains listed here are included in the
|
|
4741
|
-
* mapping are ignored. Each value defines which residues to keep
|
|
4742
|
-
* Omit design_motifs to include the chain as fixed scaffold
|
|
4776
|
+
* chains listed here are included in the pipeline run — any chains omitted from
|
|
4777
|
+
* this mapping are ignored. Each value defines which residues to keep
|
|
4778
|
+
* (crop_residues). Omit design_motifs to include the chain as fixed scaffold
|
|
4779
|
+
* context.
|
|
4743
4780
|
*/
|
|
4744
4781
|
chain_selection: {
|
|
4745
4782
|
[key: string]: StructureTemplateBinderSpec.StructureTemplatePolymerChainSpec | StructureTemplateBinderSpec.StructureTemplateLigandChainSpec;
|
|
@@ -5261,7 +5298,7 @@ export declare namespace DesignStartParams {
|
|
|
5261
5298
|
interface StructureTemplateTarget {
|
|
5262
5299
|
/**
|
|
5263
5300
|
* Chains selected from the uploaded structure, keyed by chain ID. Only chains
|
|
5264
|
-
* listed here are included in the
|
|
5301
|
+
* listed here are included in the pipeline run — any chains omitted from this
|
|
5265
5302
|
* mapping are ignored. Each value defines which residues to keep, which are
|
|
5266
5303
|
* epitope residues, which are non-binding residues, and which are flexible.
|
|
5267
5304
|
*/
|
|
@@ -5284,7 +5321,7 @@ export declare namespace DesignStartParams {
|
|
|
5284
5321
|
chain_type: 'polymer';
|
|
5285
5322
|
/**
|
|
5286
5323
|
* 0-indexed residue indices to retain from this chain, or 'all' to keep all
|
|
5287
|
-
* residues. Residues not listed are excluded from the
|
|
5324
|
+
* residues. Residues not listed are excluded from the pipeline run.
|
|
5288
5325
|
*/
|
|
5289
5326
|
crop_residues: Array<number> | 'all';
|
|
5290
5327
|
/**
|