@sjcrh/proteinpaint-client 2.225.0 → 2.226.0

package/dist/chunk-TDBS3UFZ.js

@@ -0,0 +1,379 @@
+import {
+  SPANSELECTOR,
+  renderLabelSpans,
+  trackLabelSpanData
+} from "./chunk-C2MCQZWH.js";
+import {
+  fillTermWrapper,
+  termsettingInit
+} from "./chunk-DPWSIN62.js";
+import {
+  isNumericTerm
+} from "./chunk-T2W4JHWJ.js";
+import {
+  select_default
+} from "./chunk-I6Y4O3RR.js";
+
+// plots/matrix/matrix.renderers.js
+function setRenderers(self) {
+  self.render = function() {
+    const s = self.settings.matrix;
+    const l = self.layout;
+    const d = self.dimensions;
+    const duration = self.dom.svg.attr("width") ? s.duration : 0;
+    self.dom.clipRect.attr("x", d.xOffset - 1).attr("y", 0).attr("width", d.mainw + 3).attr("height", d.mainh + 500);
+    self.renderSerieses(s, l, d, duration);
+    self.renderLabels(s, l, d, duration);
+    self.renderDivideByLabel(s, l, d, duration);
+    self.dom.colBeam.attr("width", d.dx).attr("height", d.mainh).style("stroke", s.beamStroke);
+    self.dom.rowBeam.attr("width", d.zoomedMainW).attr("height", s.rowh).style("stroke", s.beamStroke);
+  };
+  self.renderSerieses = function(s, l, d, duration) {
+    if (self.prevUseCanvas != s.useCanvas) {
+      self.dom.seriesesG.selectAll("g").remove();
+    }
+    if (s.useCanvas) {
+      const _g = self.dom.seriesesG.selectAll("g");
+      const g = (
+        /*(_g.size() && _g) ||*/
+        self.dom.seriesesG.append("g").datum(this.serieses)
+      );
+      self.renderCanvas(this.serieses, g, d, s, _g, duration);
+    } else {
+      self.dom.seriesesG.attr("transform", `translate(${d.xOffset + d.seriesXoffset},${d.yOffset})`);
+      const sg = self.dom.seriesesG.selectAll(".sjpp-mass-series-g").data(this.serieses, (series) => series.tw.$id);
+      sg.exit().remove();
+      sg.each(self.renderSeries);
+      sg.enter().append("g").attr("class", "sjpp-mass-series-g").attr("data-testid", (d2) => `sjpp-mass-series-g-${d2.tw.term.name}`).style("opacity", 1e-3).each(self.renderSeries);
+      self.mouseout();
+    }
+    self.prevUseCanvas = s.useCanvas;
+  };
+  self.renderSeries = async function(series) {
+    const s = self.settings.matrix;
+    const d = self.dimensions;
+    const g = select_default(this);
+    const duration = g.attr("transform") ? s.duration : 0;
+    g.attr("transform", `translate(${series.x},${series.y})`).style("opacity", 1);
+    const last = series.cells[series.cells.length - 1];
+    const height = series.y + last?.y + s.rowh;
+    const rects = g.selectAll("rect").data(series.cells, (cell) => cell.sample + ";;" + cell.tw.$id + ";;" + cell.valueIndex);
+    rects.exit().remove();
+    rects.each(self.renderCell);
+    rects.enter().append("rect").each(self.renderCell);
+  };
+  self.renderCanvas = async function(serieses, g, d, s, _g, duration) {
+    const pxr = window.devicePixelRatio <= 1 ? 1 : window.devicePixelRatio;
+    g.selectAll("*").remove();
+    const width = d.imgW;
+    const height = self.dimensions.mainh;
+    const canvas = window.OffscreenCanvas ? new OffscreenCanvas(width * pxr, height * pxr) : (
+      // TODO: no need to support older browser versions???
+      self.dom.holder.append("canvas").attr("width", pxr * width).attr("height", pxr * height).style("opacity", 0).node()
+    );
+    const ctx = canvas.getContext("2d");
+    ctx.imageSmoothingEnabled = false;
+    ctx.imageSmoothingQuality = "high";
+    ctx.scale(pxr, pxr);
+    for (const series of serieses) {
+      for (const cell of series.cells) {
+        self.renderCellWithCanvas(ctx, cell, series, s, d, series.y);
+      }
+    }
+    if (window.OffscreenCanvas) {
+      const reader = new FileReader();
+      reader.addEventListener(
+        "load",
+        () => {
+          _g?.remove();
+          self.dom.seriesesG.attr("transform", `translate(${d.xOffset + d.seriesXoffset},${d.yOffset})`);
+          g.selectAll("image").remove();
+          g.append("image").attr("xlink:href", reader.result).attr("x", d.xMin).attr("width", width).attr("height", height);
+        },
+        false
+      );
+      const blob = await canvas.convertToBlob({ quality: 1 });
+      const dataURL = reader.readAsDataURL(blob);
+    } else {
+      _g?.remove();
+      self.dom.seriesesG.attr("transform", `translate(${d.xOffset + d.seriesXoffset},${d.yOffset})`);
+      const dataURL = canvas.toDataURL();
+      const ratio = window.devicePixelRatio * window.devicePixelRatio;
+      g.append("image").attr("width", width).attr("height", height).attr("xlink:href", dataURL);
+      if (!window.OffscreenCanvas) canvas.remove();
+    }
+    self.mouseout();
+  };
+  self.renderCellWithCanvas = function(ctx, cell, series, s, d, _y) {
+    if (!cell.fill)
+      cell.fill = cell.$id in self.colorScaleByTermId ? self.colorScaleByTermId[cell.$id](cell.key) : getRectFill(cell);
+    const x = cell.x ? cell.x - d.xMin : 0;
+    const y = _y ? _y + cell.y : cell.y || 0;
+    const width = s.useMinPixelWidth ? Math.max(cell.width || d.colw, d.pxw) : cell.width || d.colw;
+    const height = "height" in cell ? cell.height : s.rowh;
+    ctx.fillStyle = cell.fill;
+    ctx.fillRect(x, y, width, height);
+    const borderWidth = Math.min(width, height) * 0.1;
+    if (cell.border) {
+      ctx.lineWidth = borderWidth;
+      ctx.strokeStyle = "white";
+      ctx.strokeRect(x, y, width, height);
+    }
+  };
+  self.renderCell = function(cell) {
+    if (!cell.fill)
+      cell.fill = cell.$id in self.colorScaleByTermId ? self.colorScaleByTermId[cell.$id](cell.key) : getRectFill(cell);
+    const s = self.settings.matrix;
+    const rect = select_default(this).attr("x", cell.x || 0).attr("y", cell.y || 0).attr("width", cell.width || self.dimensions.colw).attr("height", "height" in cell ? Math.max(0, cell.height) : s.rowh).attr("shape-rendering", "crispEdges").attr("fill", cell.fill);
+    if (cell.border) {
+      rect.attr("stroke", "white").attr("stroke-width", 0.8);
+    }
+  };
+  self.renderLabels = function(s, l, d, duration) {
+    const relatedSamplesByAncestorId = /* @__PURE__ */ new Map();
+    for (const direction of ["top", "btm", "left", "right"]) {
+      let renderLabel2 = function(lab) {
+        const g = select_default(this);
+        g.attr("transform", side.attr.labelGTransform);
+        if (!g.select(":scope>text").size()) g.append("text");
+        const showContAxis = !side.isGroup && lab.grp?.type !== "hierCluster" && lab.tw?.q?.mode == "continuous";
+        const labelText = side.label(lab);
+        const text = g.select(":scope>text").attr("fill", "#000").attr("data-testid", `sjpp-matrix-label-${direction}`).style("display", side.display || "");
+        let continuousBarHAdjust;
+        const twSpecificSettings = self.config.settings.matrix.twSpecificSettings;
+        const twSettingsBarH = twSpecificSettings[lab.tw?.$id]?.contBarH;
+        if (twSettingsBarH && s.barh) continuousBarHAdjust = (twSettingsBarH - s.barh) * 0.5;
+        text.attr(
+          "display",
+          lab.grp?.type === "hierCluster" && s.clusterRowh < 6 ? "none" : side.attr.fontSize < 6 || labelText === "configure" ? "none" : ""
+        ).attr("font-size", lab.grp?.type === "hierCluster" ? Math.max(4, s.clusterRowh - 4) : side.attr.fontSize).attr("text-anchor", side.attr.labelAnchor).attr(
+          "transform",
+          side.attr.labelTransform + (continuousBarHAdjust ? ` translate(0,${continuousBarHAdjust})` : "")
+        ).attr("cursor", "pointer").attr(side.attr.textpos.coord, side.attr.textpos.factor * (showContAxis ? 30 : 0));
+        if (!Array.isArray(labelText)) {
+          text.text(labelText);
+          text.attr(
+            "y",
+            lab.grp?.type !== "hierCluster" && lab.tw?.q?.mode == "continuous" ? 10 : lab.grp?.type === "hierCluster" ? 0.1 * s.clusterRowh : 0
+          );
+          if (lab.grp?.type !== "hierCluster" && lab.tw?.q?.mode == "continuous") text.attr("x", -20);
+        } else {
+          text.text("");
+          const tspan = text.selectAll("tspan").data(labelText);
+          tspan.enter().append("tspan").attr("class", getTspanCls2).attr("dx", getTspanDx2).attr("font-size", getTspanFontSize2).text(getTspanText2);
+        }
+        text.on("mouseover", labelText === "configure" ? () => text.attr("opacity", 0.5) : null).on("mouseout", labelText === "configure" ? () => text.attr("opacity", 0) : null);
+        const hasAxis = g.select(".sjpp-matrix-cell-axis").size() && true;
+        if (showContAxis && labelText) {
+          if (!hasAxis) {
+            g.append("g").attr("class", "sjpp-matrix-cell-axis").attr("shape-rendering", "crispEdges");
+          }
+          const axisg = g.select(".sjpp-matrix-cell-axis");
+          axisg.selectAll("*").remove();
+          const domain = [lab.counts.maxval, lab.counts.minval];
+          if (s.transpose) domain.reverse();
+          const twSpecificSettings2 = self.config.settings.matrix.twSpecificSettings;
+          const twSettings = twSpecificSettings2[lab.tw.$id];
+          const x = !s.transpose ? 0 : twSettings.contBarGap - 1 - lab.labelOffset;
+          const y = !s.transpose ? twSettings.contBarGap - 1 - lab.labelOffset : 0;
+          axisg.attr("shape-rendering", "crispEdges").attr("transform", `translate(${x},${y})`).call(side.attr.axisFxn(lab.scales.full.domain(lab.scales.tickValues)).tickValues(lab.scales.tickValues));
+        } else if (hasAxis) {
+          g.select(".sjpp-matrix-cell-axis").remove();
+        }
+        if (self.config.chartType == "matrix" && s.sortBySampleAncestry && side.prefix == "sample")
+          trackLabelSpanData(lab, side, direction, text, relatedSamplesByAncestorId);
+      }, getTspanCls2 = function(d2) {
+        return d2.cls;
+      }, getTspanDx2 = function(d2) {
+        return d2.dx;
+      }, getTspanFontSize2 = function(d2) {
+        return d2.fontSize || side.attr.fontSize;
+      }, getTspanText2 = function(d2) {
+        return d2.text;
+      };
+      var renderLabel = renderLabel2, getTspanCls = getTspanCls2, getTspanDx = getTspanDx2, getTspanFontSize = getTspanFontSize2, getTspanText = getTspanText2;
+      const side = l[direction];
+      side.box.style("display", side.display || "").attr("transform", side.attr.boxTransform);
+      const labels = side.box.selectAll(".sjpp-matrix-label").data(side.data, side.key);
+      labels.exit().remove();
+      labels.each(renderLabel2);
+      labels.enter().append("g").attr("class", "sjpp-matrix-label").each(renderLabel2);
+      side.box.selectAll(SPANSELECTOR).remove();
+      if (self.config.chartType == "matrix" && s.sortBySampleAncestry && side.prefix == "sample")
+        renderLabelSpans(relatedSamplesByAncestorId, side, d);
+    }
+  };
+  self.colLabelGTransform = (lab, grpIndex) => {
+    const s = self.settings.matrix;
+    const d = self.dimensions;
+    lab.labelOffset = 0.8 * d.colw;
+    const x = lab.grpIndex * s.colgspace + lab.totalIndex * d.dx + lab.labelOffset + lab.totalHtAdjustments;
+    const y = 0;
+    return `translate(${x + d.seriesXoffset},${y})`;
+  };
+  self.colGrpLabelGTransform = (lab, grpIndex) => {
+    const s = self.settings.matrix;
+    const d = self.dimensions;
+    const len = (lab.processedLst || lab.grp.lst).length;
+    const x = lab.grpIndex * s.colgspace + lab.prevGrpTotalIndex * d.dx + len * d.dx / 2 + s.grpLabelFontSize / 2 + lab.totalHtAdjustments;
+    return `translate(${x + d.seriesXoffset},0)`;
+  };
+  self.rowLabelGTransform = (lab, grpIndex) => {
+    const s = self.settings.matrix;
+    const d = self.dimensions;
+    const x = 0;
+    lab.labelOffset = 0.7 * (lab.grp.type == "hierCluster" ? s.clusterRowh : s.rowh);
+    const y = lab.grpIndex * s.rowgspace + lab.totalIndex * d.dy + lab.labelOffset + lab.totalHtAdjustments;
+    return `translate(${x},${y})`;
+  };
+  self.rowGrpLabelGTransform = (lab, grpIndex) => {
+    const s = self.settings.matrix;
+    const d = self.dimensions;
+    const len = (lab.processedLst || lab.grp.lst).length;
+    const x = lab.tw?.q?.mode == "continuous" ? 20 : 0;
+    const y = lab.grpIndex * s.rowgspace + lab.prevGrpTotalIndex * d.dy + len * d.dy / 2 + s.grpLabelFontSize / 2 + lab.totalHtAdjustments;
+    return `translate(${x},${y})`;
+  };
+  self.rowAxisGTransform = (lab, grpIndex) => {
+    const s = self.settings.matrix;
+    const d = self.dimensions;
+    const x = 0;
+    const y = lab.grpIndex * s.rowgspace + lab.totalIndex * d.dy + 0.7 * s.rowh + lab.totalHtAdjustments;
+    return `translate(${x},${y})`;
+  };
+  self.renderDivideByLabel = async (s, l, d) => {
+    self.dom.mainG.selectAll(".sjpp-matrix-divide-by-label").remove();
+    if (!self.config.divideBy) return;
+    const name = self.config.divideBy?.term.name || "";
+    const text = name.length <= s.rowlabelmaxchars ? name : name.slice(0, s.rowlabelmaxchars) + "\u2026";
+    const sides = !s.transpose ? [l.left, l.right] : [l.top, l.bottom];
+    const box = sides.find((d2) => !d2.isGroup)?.box;
+    const y = (s.collabelpos == "top" ? d.mainh + s.collabelmaxchars : -s.collabelmaxchars) + 8;
+    const anchor = s.rowlabelpos == "left" ? "end" : "start";
+    const cl = s.controlLabels;
+    const gNote = box.append("g").attr("class", "sjpp-matrix-divide-by-label").attr("transform", `translate(0, ${y})`);
+    gNote.append("text").attr("text-anchor", anchor).attr("font-style", "italic").attr("y", -20).text(`${cl.Samples} grouped by`);
+    const g = box.datum({ tw: self.config.divideBy }).append("g").attr("class", "sjpp-matrix-divide-by-label").attr("transform", `translate(0, ${y})`).on("click", (event, d2) => {
+      pill.showMenu(event, textElem.node());
+    });
+    const textElem = g.append("text").attr("text-anchor", anchor).attr("font-weight", 600).text(text);
+    g.append("title").text(`${cl.Samples} are grouped by this gene or variable. Click to edit.`);
+    const customMenuOptions = [];
+    const tvsKey = isNumericTerm(self.config.divideBy.term) ? "ranges" : "values";
+    if (self.config.legendValueFilter.lst?.find(
+      (l2) => l2.legendGrpName == self.config.divideBy.term.id || l2.legendGrpName == self.config.divideBy.term.name
+    )?.tvs[tvsKey]?.length) {
+      customMenuOptions.push({ label: `Show filtered ${cl.samples}`, callback: self.showDeletedSampleGroups });
+    }
+    const pill = await termsettingInit({
+      menuOptions: "{edit,replace,remove}",
+      //numericEditMenuVersion: opts.numericEditMenuVersion,
+      customMenuOptions,
+      //custom menu options other than menuOptions
+      vocabApi: self.app.vocabApi,
+      vocab: self.state.vocab,
+      //activeCohort: opts.state?.activeCohort,
+      holder: g,
+      debug: self.opts.debug,
+      usecase: { target: "matrix" },
+      getBodyParams: () => {
+        const currentGeneNames = self.termOrder.filter((t) => t.tw.term.type === "geneVariant").map(
+          (t) => t.tw.term.chr ? `${t.tw.term.chr}:${t.tw.term.start}-${t.tw.term.stop}` : t.tw.term.gene || t.tw.term.name
+        );
+        if (currentGeneNames.length) return { currentGeneNames };
+        return {};
+      },
+      callback: async (tw) => {
+        if (self.dom.loadingDiv && self.dom.svg) {
+          self.dom.loadingDiv.selectAll("*").remove();
+          self.dom.loadingDiv.html("").style("display", "").style("position", "relative").style("left", "45%");
+          self.dom.loadingDiv.html("Processing data ...");
+          self.dom.svg.style("opacity", 0.1).style("pointer-events", "none");
+        }
+        if (tw && !tw.q) throw "data.q{} missing from pill callback";
+        if (tw?.term && isNumericTerm(tw.term)) {
+          tw.q = { ...tw.q, mode: "discrete" };
+        }
+        if (tw) await fillTermWrapper(tw, self.app.vocabApi);
+        await pill.main(tw ? tw : { term: null, q: null });
+        box.datum({ tw });
+        self.app.dispatch({
+          type: "plot_edit",
+          id: self.id,
+          config: {
+            divideBy: tw,
+            legendValueFilter: self.mayRemoveTvsEntry(self.config.divideBy)
+          }
+        });
+      }
+    });
+    const arg = {
+      term: self.config.divideBy.term,
+      q: self.config.divideBy.q
+    };
+    if (self.config.divideBy.$id) arg.$id = self.config.divideBy.$id;
+    pill.main(arg);
+  };
+  self.adjustSvgDimensions = async function(prevTranspose) {
+    const s = self.settings.matrix;
+    const hc = self.settings.hierCluster || {};
+    const l = self.layout;
+    const hcHeight = !hc.yDendrogramHeight ? 0 : hc.yDendrogramHeight + (l.top.display === "none" ? 0 : 10);
+    const hcWidth = hc.xDendrogramHeight || 0;
+    const d = self.dimensions;
+    const duration = self.dom.svg.attr("width") ? s.duration : 0;
+    await sleep(prevTranspose == s.transpose ? duration : s.duration);
+    const topBox = l.top.box.node().getBBox();
+    const btmBox = l.btm.box.node().getBBox();
+    const leftBox = l.left.box.node().getBBox();
+    const rtBox = l.right.box.node().getBBox();
+    const legendBox = self.dom.legendG.node().getBBox();
+    const seriesBox = self.dom.seriesesG.node().getBBox();
+    d.extraWidth = leftBox.width + rtBox.width + s.margin.left + s.margin.right + s.rowlabelgap * 2;
+    d.extraHeight = topBox.height + btmBox.height + s.margin.top + s.margin.bottom + s.collabelgap * 2;
+    d.svgw = d.mainw + d.extraWidth + hcWidth;
+    d.svgh = d.mainh + d.extraHeight + legendBox.height + 20 + s.scrollHeight + hcHeight;
+    self.dom.svg.attr("width", d.svgw).attr("height", d.svgh);
+    let maxLabelWidth = self.type == "hierCluster" ? 0 : leftBox.width, maxLabelNumChars = 0;
+    if (hc.xDendrogramHeight) {
+      self.dom.termLabelG.selectAll(".sjpp-matrix-label").each(function(d2) {
+        if (d2.grp.type !== "hierCluster") return;
+        const box = this.getBBox();
+        if (box.width > maxLabelWidth) {
+          maxLabelWidth = box.width;
+          maxLabelNumChars = d2.label.length;
+        }
+      });
+    }
+    const x = -l.left.offset + hcWidth + maxLabelWidth;
+    const xAdjust = !hc.xDendrogramHeight ? 0 : Math.max(leftBox.width - (hc.xDendrogramHeight + maxLabelWidth), 0);
+    const y = (l.top.display == "none" ? 0 : topBox.height) - l.top.offset + hcHeight;
+    self.dom.mainG.attr("transform", `translate(${x + xAdjust},${y})`);
+    self.dom.clipRect.attr("y", -y).attr("height", d.mainh + 500 + y);
+    const legendX = d.xOffset + (s.transpose ? 20 : 0);
+    const legendY = d.yOffset + d.mainh + s.collabelgap + (l.btm.display == "none" ? 0 : btmBox.height) + 20;
+    self.dom.legendG.attr("transform", `translate(${legendX},${legendY})`);
+    if (hc.xDendrogramHeight) {
+      const dendroX = maxLabelWidth + xAdjust - l.left.offset + d.xOffset - d.dx / 2;
+      self.dom.hcClipRect.attr("x", dendroX + hcWidth + d.dx / 2).attr("y", 0).attr("width", d.mainw + 3).attr("height", d.mainh + hc.yDendrogramHeight + 500);
+      self.topDendroX = dendroX + d.seriesXoffset;
+      self.dom.topDendrogram.attr("transform", `translate(${self.topDendroX}, 0)`);
+      const y2 = l.top.display == "none" ? 0 : topBox.height + s.collabelgap;
+      self.dom.leftDendrogram.attr("transform", `translate(${dendroX - maxLabelWidth - 10}, ${y2})`);
+    }
+  };
+}
+function getRectFill(d) {
+  if (d.fill) return d.fill;
+  const cls = d.class || Array.isArray(d.values) && d.values[0].class;
+  if (!cls) console.log;
+  return cls ? mclass[cls].color : "#555";
+}
+function sleep(ms) {
+  return new Promise((resolve) => setTimeout(resolve, ms));
+}
+
+export {
+  setRenderers
+};
+//# sourceMappingURL=chunk-TDBS3UFZ.js.map

package/dist/chunk-THHYPA5K.js

@@ -0,0 +1,48 @@
+import {
+  addGeneSearchbox,
+  getGEunit,
+  getTermSampleTypes,
+  mayRenderSampleTypeRow
+} from "./chunk-DPWSIN62.js";
+import {
+  Menu
+} from "./chunk-CNFTQSNE.js";
+import {
+  TermTypes
+} from "./chunk-2N345NXD.js";
+
+// termdb/handlers/geneExpression.ts
+var SearchHandler = class {
+  init(opts) {
+    this.callback = opts.callback;
+    this.app = opts.app;
+    this.dom = {};
+    const holder = opts.holder.append("div").style("padding", "10px 0px");
+    this.sampleTypeSelect = mayRenderSampleTypeRow(holder.append("div"), this.query, this.app.vocabApi.termdbConfig);
+    const geneSearch = addGeneSearchbox({
+      tip: new Menu({ padding: "0px" }),
+      genome: opts.genomeObj,
+      row: holder,
+      searchOnly: "gene",
+      callback: () => this.selectGene(geneSearch)
+    });
+    holder.select(".sja_genesearchinput").style("margin", "0px");
+  }
+  get query() {
+    return this.app.vocabApi.termdbConfig?.queries.geneExpression;
+  }
+  async selectGene(geneSearch) {
+    const gene = geneSearch?.geneSymbol;
+    if (!gene) throw new Error("No gene selected");
+    const termSampleTypes = getTermSampleTypes(this.sampleTypeSelect, this.query, this.app.vocabApi.termdbConfig);
+    if (!termSampleTypes) return;
+    const unit = getGEunit(this.app.vocabApi);
+    const name = `${gene} ${unit}`;
+    this.callback({ gene, name, type: TermTypes.GENE_EXPRESSION, ...termSampleTypes });
+  }
+};
+
+export {
+  SearchHandler
+};
+//# sourceMappingURL=chunk-THHYPA5K.js.map

package/dist/chunk-THHYPA5K.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../termdb/handlers/geneExpression.ts"],
+  "sourcesContent": ["import { Menu, addGeneSearchbox, mayRenderSampleTypeRow, getTermSampleTypes } from '#dom'\nimport { TermTypes } from '#types'\nimport { getGEunit } from '#tw/geneExpression'\n\nexport class SearchHandler {\n\tcallback: any\n\tapp: any\n\tdom: any\n\tsampleTypeSelect?: any\n\tinit(opts) {\n\t\tthis.callback = opts.callback\n\t\tthis.app = opts.app\n\t\tthis.dom = {}\n\t\tconst holder = opts.holder.append('div').style('padding', '10px 0px')\n\t\tthis.sampleTypeSelect = mayRenderSampleTypeRow(holder.append('div'), this.query, this.app.vocabApi.termdbConfig)\n\t\tconst geneSearch = addGeneSearchbox({\n\t\t\ttip: new Menu({ padding: '0px' }),\n\t\t\tgenome: opts.genomeObj,\n\t\t\trow: holder,\n\t\t\tsearchOnly: 'gene',\n\t\t\tcallback: () => this.selectGene(geneSearch)\n\t\t})\n\t\tholder.select('.sja_genesearchinput').style('margin', '0px')\n\t}\n\n\tget query() {\n\t\treturn this.app.vocabApi.termdbConfig?.queries.geneExpression\n\t}\n\n\tasync selectGene(geneSearch) {\n\t\tconst gene = geneSearch?.geneSymbol\n\t\tif (!gene) throw new Error('No gene selected')\n\t\tconst termSampleTypes = getTermSampleTypes(this.sampleTypeSelect, this.query, this.app.vocabApi.termdbConfig)\n\t\tif (!termSampleTypes) return\n\t\tconst unit = getGEunit(this.app.vocabApi)\n\t\tconst name = `${gene} ${unit}`\n\t\tthis.callback({ gene, name, type: TermTypes.GENE_EXPRESSION, ...termSampleTypes })\n\t}\n}\n"],
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+  "names": []
+}

package/dist/chunk-U2OB3S3M.js

@@ -0,0 +1,14 @@
+// src/block.lazyload.js
+var Block;
+async function blocklazyload(arg) {
+  if (!Block) {
+    const b = await import("./block-YGQFUK5L.js");
+    Block = b.Block;
+  }
+  return new Block(arg);
+}
+
+export {
+  blocklazyload
+};
+//# sourceMappingURL=chunk-U2OB3S3M.js.map

package/dist/chunk-UA2ADBTO.js

@@ -0,0 +1,42 @@
+import {
+  defaultMaxPairwiseTestGroups
+} from "./chunk-6V7ITU5F.js";
+import {
+  plotColor
+} from "./chunk-2N345NXD.js";
+
+// plots/violin/settings/defaults.ts
+function getDefaultViolinSettings(app, overrides = {}) {
+  const defaults = {
+    orientation: "horizontal",
+    rowlabelw: 250,
+    brushRange: null,
+    //object with start and end if there is a brush selection
+    svgw: 500,
+    // span length of a plot/svg, not including margin
+    datasymbol: "rug",
+    radius: 10,
+    axisHeight: 60,
+    rightMargin: 50,
+    lines: [],
+    isLogScale: false,
+    // false: linear scale, true: log scale
+    rowSpace: 10,
+    medianLength: 7,
+    medianColor: "#FF0000",
+    medianThickness: 3,
+    ticks: 15,
+    defaultColor: plotColor,
+    method: 0,
+    orderByMedian: false,
+    showStats: true,
+    showAssociationTests: true,
+    maxPairwiseTestGroups: defaultMaxPairwiseTestGroups
+  };
+  return Object.assign(defaults, overrides);
+}
+
+export {
+  getDefaultViolinSettings
+};
+//# sourceMappingURL=chunk-UA2ADBTO.js.map

package/dist/chunk-USGUVW5Q.js

@@ -0,0 +1,182 @@
+import {
+  Tabs,
+  addGeneSearchbox,
+  make_one_checkbox,
+  make_radios
+} from "./chunk-DPWSIN62.js";
+import {
+  Menu
+} from "./chunk-CNFTQSNE.js";
+import {
+  termType2label
+} from "./chunk-T2W4JHWJ.js";
+import {
+  TermTypeGroups
+} from "./chunk-2N345NXD.js";
+
+// termdb/handlers/pseudobulk.ts
+var SearchHandler = class {
+  async init(opts) {
+    const pseudobulkTerms = this.validateOpts(opts);
+    this.callback = opts.callback;
+    this.app = opts.app;
+    this.genome = opts.genomeObj;
+    const holder = opts.holder.append("div").style("padding", "10px 0px");
+    this.multiSelect = opts?.usecase?.target == "aggregateMatrix";
+    this.selectedTerm = void 0;
+    this.map = this.buildRenderingDataMap(pseudobulkTerms);
+    this.renderPseudobulkSearch(holder);
+  }
+  validateOpts(opts) {
+    if (!opts) throw new Error("opts is required");
+    if (!opts.app) throw new Error("opts.app is required");
+    if (!opts.holder) throw new Error("opts.holder is required");
+    if (opts.genomeObj == null || typeof opts.genomeObj !== "object") throw new Error("genomeObj is required");
+    if (!opts.callback) throw new Error("opts.callback is required");
+    const pseudobulkTerms = opts.app.vocabApi.termdbConfig?.termType2terms?.[TermTypeGroups.PSEUDOBULK];
+    if (!pseudobulkTerms?.length) {
+      throw new Error(
+        `termType2terms[${TermTypeGroups.PSEUDOBULK}]:[] is required in termdbConfig for pseudobulk handler`
+      );
+    }
+    return pseudobulkTerms;
+  }
+  /** Builds a map from assay to memberId to terms */
+  buildRenderingDataMap(pseudobulkTerms) {
+    const map = /* @__PURE__ */ new Map();
+    for (const term of pseudobulkTerms) {
+      const { assay, memberId } = term;
+      if (!map.has(assay)) map.set(assay, /* @__PURE__ */ new Map());
+      const assayMap = map.get(assay);
+      if (!assayMap.has(memberId)) assayMap.set(memberId, []);
+      assayMap.get(memberId).push(term);
+    }
+    return map;
+  }
+  /** If more than one assay, render tabs for each assay. Member IDs within
+   * an assay are rendered as tabs when there is more than one. */
+  renderPseudobulkSearch(holder) {
+    if (!this.map || this.map.size < 1) throw new Error("map is not initialized");
+    if (this.map.size === 1) {
+      const label = termType2label(this.map.keys().next().value);
+      holder.append("div").style("padding-bottom", "10px").text("Single-cell pseudobulk " + label);
+      this.renderMemberIdsByAssay(holder.append("div"), this.map);
+      return;
+    }
+    const tabs = this.buildTabsOpts(this.map);
+    new Tabs({ holder, tabs, tabsPosition: "vertical" }).main();
+  }
+  buildTabsOpts(map) {
+    const tabs = [];
+    for (const [key, valuesMap] of map.entries()) {
+      const label = termType2label(key);
+      tabs.push({
+        label,
+        active: false,
+        callback: (_, tab) => {
+          this.renderMemberIdsByAssay(tab.contentHolder, /* @__PURE__ */ new Map([[key, valuesMap]]));
+        }
+      });
+    }
+    return tabs;
+  }
+  renderMemberIdsByAssay(holder, map) {
+    const memberIdMap = map.values().next().value;
+    holder.selectAll("*").remove();
+    this.renderTermdByMemberId(holder, memberIdMap);
+  }
+  renderTermdByMemberId(holder, memberIdMap) {
+    const layout = holder.append("div").style("display", "flex").style("align-items", "flex-start").style("gap", "30px");
+    const pseudoTermsWrapper = layout.append("div").attr("data-testid", "sjpp-pseudobulk-terms-wrapper");
+    const geneSearchWrapper = layout.append("div").attr("data-testid", "sjpp-pseudobulk-gene-search-wrapper");
+    this.renderPseudobulkTerms(pseudoTermsWrapper, memberIdMap, geneSearchWrapper);
+  }
+  renderPseudobulkTerms(holder, memberIdMap, geneSearchHolder) {
+    if (memberIdMap.size === 1) {
+      const [memberId, terms] = memberIdMap.entries().next().value;
+      if (this.multiSelect) {
+        this.renderCategoriesAsTerms(holder, terms);
+      } else this.renderCategoryRadios(holder, memberId, terms, geneSearchHolder);
+      return;
+    }
+    const memberEntries = Array.from(memberIdMap.entries());
+    const tabs = memberEntries.map(([memberId, terms]) => ({
+      label: memberId,
+      active: false,
+      testid: `sjpp-pseudobulk-member-${memberId}`,
+      callback: (_, tab) => {
+        geneSearchHolder.selectAll("*").remove();
+        tab.contentHolder.selectAll("*").remove();
+        if (this.multiSelect) this.renderCategoriesAsTerms(tab.contentHolder, terms);
+        else this.renderCategoryRadios(tab.contentHolder, memberId, terms, geneSearchHolder);
+      }
+    }));
+    new Tabs({ holder, tabs, tabsPosition: "vertical" }).main();
+  }
+  renderCategoryRadios(holder, memberId, terms, geneSearchHolder) {
+    if (!terms || terms.length < 1) throw new Error("No terms found for memberId");
+    const options = terms.map((term) => ({
+      label: term.name,
+      value: term.id,
+      checked: false,
+      testid: `sjpp-pseudobulk-category-${term.id}`
+    }));
+    make_radios({
+      holder,
+      inputName: `sjpp-pseudobulk-category-radios-${memberId}`,
+      options,
+      styles: { display: "block", padding: "3px 5px" },
+      callback: (value) => {
+        const term = terms.find((term2) => term2.id == value);
+        if (!term) throw new Error(`No pseudobulk term found for category ${value}`);
+        this.selectedTerm = term;
+        this.renderGeneSelection(geneSearchHolder);
+      }
+    });
+  }
+  renderGeneSelection(holder) {
+    holder.selectAll("*").remove();
+    const geneSearch = addGeneSearchbox({
+      tip: new Menu({ padding: "0px" }),
+      genome: this.genome,
+      row: holder,
+      searchOnly: "gene",
+      callback: () => {
+        if (!geneSearch.geneSymbol) throw new Error("No gene selected");
+        if (!this.selectedTerm) throw new Error("No pseudobulk cell type selected");
+        this.callback(createPseudobulkTerm(this.selectedTerm, geneSearch.geneSymbol));
+      }
+    });
+  }
+  /** Mimics the style and functionality of pills created in tree.js.
+   * Returns the term object(s) from termdbConfig.termType2terms.[TermTypeGroups.PSEUDOBULK]
+   * without the gene. */
+  renderCategoriesAsTerms(holder, terms) {
+    holder.style("padding", "0px 10px");
+    make_one_checkbox({
+      holder,
+      labeltext: "Select all",
+      divstyle: { opacity: "0.7" },
+      callback: () => this.callback(terms)
+    });
+    const wrapper = holder.append("div").style("display", "block").style("padding", "10px 15px 0px");
+    wrapper.selectAll(".pseudobulk-term").data(terms, (term) => term.id).join((enter) => {
+      const row = enter.append("div").attr("class", "pseudobulk-term");
+      row.append("div").attr("class", "termlabel sja_filter_tag_btn sja_tree_click_term ts_pill").style("padding", "5px 8px").style("margin", "1px 0px").style("border-radius", "6px").text((term) => term.name).on("click", async (_, term) => {
+        await this.callback(term);
+      });
+      return row;
+    });
+  }
+};
+function createPseudobulkTerm(selectedTerm, gene) {
+  const category = selectedTerm.category || selectedTerm.id;
+  const name = `${selectedTerm.assay} ${category} ${gene}`;
+  return { ...selectedTerm, id: name, category, gene, name };
+}
+
+export {
+  SearchHandler,
+  createPseudobulkTerm
+};
+//# sourceMappingURL=chunk-USGUVW5Q.js.map