@sjcrh/proteinpaint-client 2.224.0 → 2.224.1

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (862) hide show
  1. package/dist/2dmaf-7HOQRW25.js +1362 -0
  2. package/dist/AggMatrixInput-LMVRNQBN.js +402 -0
  3. package/dist/AggregateMatrix-AMQTLJV2.js +37 -0
  4. package/dist/AppHeader-AK7O2HUI.js +826 -0
  5. package/dist/BoxPlot-CE5JWPJH.js +1229 -0
  6. package/dist/CorrelationVolcano-DO7I63FR.js +613 -0
  7. package/dist/Cuminc-NHABXYET.js +1217 -0
  8. package/dist/DE-A327BZNW.js +85 -0
  9. package/dist/DEinput-VKRBFYUE.js +479 -0
  10. package/dist/DM-NU23H5PL.js +86 -0
  11. package/dist/DifferentialAnalysis-SH47YDQQ.js +236 -0
  12. package/dist/Disco-DOLET5UY.js +3384 -0
  13. package/dist/Disco.UI-6J6INV56.js +239 -0
  14. package/dist/DmrPlot-KYZOQB2Y.js +361 -0
  15. package/dist/GB-LQCK6YNB.js +1388 -0
  16. package/dist/GSEA-KLTV4JDP.js +870 -0
  17. package/dist/GeneExpInput-ZMTWWDO7.js +38 -0
  18. package/dist/Geomap-4NP2JPMA.js +80 -0
  19. package/dist/HicApp-DXF6B4YR.js +2240 -0
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  21. package/dist/NumBinaryEditor-JZZS67NB.js +274 -0
  22. package/dist/NumBinaryEditor.unit.spec-S2MKCJYX.js +308 -0
  23. package/dist/NumContEditor-IRZPIDJU.js +100 -0
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  25. package/dist/NumCustomBinEditor-E2FJNISZ.js +29 -0
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  27. package/dist/NumDiscreteEditor-JECWQKST.js +165 -0
  28. package/dist/NumDiscreteEditor.unit.spec-DG52CSV5.js +229 -0
  29. package/dist/NumRegularBinEditor-W726TJIB.js +29 -0
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  31. package/dist/NumSplineEditor-7UYPJI57.js +205 -0
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  35. package/dist/NumericHandler-EJHWVASI.js +30 -0
  36. package/dist/NumericHandler.unit.spec-VUIGKU4C.js +225 -0
  37. package/dist/ProteomeInput-ATBCNQLN.js +610 -0
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  39. package/dist/RunChart2-NUSOF6LW.js +744 -0
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  43. package/dist/Wsi-CC7GX3HL.js +636 -0
  44. package/dist/aboutSunburst-VTBLSKCY.js +93 -0
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  46. package/dist/animatedBubbleChart-BRGFUEYW.js +542 -0
  47. package/dist/app-2GMWQIJZ.js +28 -0
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  135. package/dist/cohortSunburst-HIWGWD7A.js +402 -0
  136. package/dist/condition-KEFHKNUU.js +323 -0
  137. package/dist/controls-MDUZLMY7.js +30 -0
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  140. package/dist/customdata.inputui-6KIPVY2Q.js +280 -0
  141. package/dist/dataDownload-XCFCSKDO.js +326 -0
  142. package/dist/databrowser.ui-HLWUAHSZ.js +421 -0
  143. package/dist/dictionary-P5JGXQSW.js +109 -0
  144. package/dist/dnaMethylation-ZNR5U6HS.js +29 -0
  145. package/dist/dnaMethylation.integration.spec-7AMBXA4M.js +194 -0
  146. package/dist/e2pca-AJQ22AHJ.js +340 -0
  147. package/dist/ep-3ZEN3C4U.js +1247 -0
  148. package/dist/expclust.gdc.spec-IQXJYSCH.js +298 -0
  149. package/dist/facet-RPFQA3DH.js +556 -0
  150. package/dist/gb-R4D647D2.js +77 -0
  151. package/dist/geneExpClustering-JLJL6S3Q.js +240 -0
  152. package/dist/geneExpression-NWNOCRVM.js +309 -0
  153. package/dist/geneExpression-NWNOCRVM.js.map +7 -0
  154. package/dist/geneExpression-TK75VNQG.js +29 -0
  155. package/dist/geneExpression.unit.spec-4HTUTQ5K.js +151 -0
  156. package/dist/geneORA-7FP6KZSE.js +269 -0
  157. package/dist/geneRanking-SBFOUZTQ.js +544 -0
  158. package/dist/geneVariant-3DHX4LQL.js +289 -0
  159. package/dist/geneVariant-SUQWO6ON.js +32 -0
  160. package/dist/geneVariant.integration.spec-KOUVJAFB.js +672 -0
  161. package/dist/genefusion.ui-DAIBYS5I.js +299 -0
  162. package/dist/geneset-MKSYRPV4.js +199 -0
  163. package/dist/genomeBrowser.spec-JSHMD3CR.js +272 -0
  164. package/dist/grin2-RFRYBHBV.js +945 -0
  165. package/dist/grin2-Z4ETF6OM.js +66 -0
  166. package/dist/hierCluster-C67VO3VF.js +55 -0
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  209. package/dist/profileForms-LHJCFAP6.js +937 -0
  210. package/dist/profilePlot-UF2KERDD.js +45 -0
  211. package/dist/proteinView-5AF4I3PB.js +1346 -0
  212. package/dist/proteomeCohortCompare-4DYWZTLQ.js +866 -0
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  803. /package/dist/{singleCellGeneExpression-LPDACSPJ.js.map → singleCellGeneExpression-QDRIVFQ5.js.map} +0 -0
  804. /package/dist/{singleCellGeneExpression.unit.spec-JZHG5OAH.js.map → singleCellGeneExpression.unit.spec-FHUA6VWD.js.map} +0 -0
  805. /package/dist/{singleCellNumericValue-SDUSPCBR.js.map → singleCellNumericValue-2PKMS7NM.js.map} +0 -0
  806. /package/dist/{singleCellNumericValue.unit.spec-VQSNCIJC.js.map → singleCellNumericValue.unit.spec-YXDYOFJ5.js.map} +0 -0
  807. /package/dist/{singleCellPlot-5AAE5QGD.js.map → singleCellPlot-5RVA7KM7.js.map} +0 -0
  808. /package/dist/{singlecell-MUI27JKF.js.map → singlecell-5OUPDXEQ.js.map} +0 -0
  809. /package/dist/{singlecell-7XO5TLVF.js.map → singlecell-MLKBNJAG.js.map} +0 -0
  810. /package/dist/{snp-2QX25UKB.js.map → snp-ARLPF6ZU.js.map} +0 -0
  811. /package/dist/{snp.unit.spec-6B7ZUD7Q.js.map → snp.unit.spec-MUB7YKMP.js.map} +0 -0
  812. /package/dist/{snplocus-GMWNSSHV.js.map → snplocus-EZ33TXDU.js.map} +0 -0
  813. /package/dist/{snplst-6NAHQAXI.js.map → snplst-GLTNXAE5.js.map} +0 -0
  814. /package/dist/{spliceevent.a53ss.diagram-WUHKYRWG.js.map → spliceevent.a53ss.diagram-FMP6CNCV.js.map} +0 -0
  815. /package/dist/{spliceevent.exonskip.diagram-KAFGBL2I.js.map → spliceevent.exonskip.diagram-QRQ3DZ3I.js.map} +0 -0
  816. /package/dist/{spliceevent.noeventdiagram-SUBU5BLZ.js.map → spliceevent.noeventdiagram-LAPCKJS3.js.map} +0 -0
  817. /package/dist/{ssGSEA-V4W3E6MF.js.map → ssGSEA-WUE2PKUU.js.map} +0 -0
  818. /package/dist/{ssGSEA.unit.spec-DYMT2CCB.js.map → ssGSEA.unit.spec-Y7KCKEGK.js.map} +0 -0
  819. /package/dist/{stattable-DJCYOA6Y.js.map → stattable-GZF4ZWTT.js.map} +0 -0
  820. /package/dist/{studyCatalog-TOGQ24WQ.js.map → studyCatalog-PPV7WB2O.js.map} +0 -0
  821. /package/dist/{summarizeCnvGeneexp-6Z3VVSMQ.js.map → summarizeCnvGeneexp-LZ7UWWZS.js.map} +0 -0
  822. /package/dist/{summarizeGeneexpSurvival-REIPWAEJ.js.map → summarizeGeneexpSurvival-VBRJFZR6.js.map} +0 -0
  823. /package/dist/{summarizeMutationCnv-OJNIJR55.js.map → summarizeMutationCnv-6LUM4YR7.js.map} +0 -0
  824. /package/dist/{summarizeMutationDiagnosis-PVOTM3DF.js.map → summarizeMutationDiagnosis-B47HKNM6.js.map} +0 -0
  825. /package/dist/{summarizeMutationSurvival-X7TV3EKS.js.map → summarizeMutationSurvival-6GH3MTLN.js.map} +0 -0
  826. /package/dist/{summary-RNNIEEHQ.js.map → summary-BBI7MS3B.js.map} +0 -0
  827. /package/dist/{summary.integration.spec-PEICP7YJ.js.map → summary.integration.spec-SYLP7X3F.js.map} +0 -0
  828. /package/dist/{summaryInput-53MQOUXV.js.map → summaryInput-5PPK7KRL.js.map} +0 -0
  829. /package/dist/{sunburst-MYKDYBVD.js.map → sunburst-BVPS44ZR.js.map} +0 -0
  830. /package/dist/{sunburst-OMNCQM26.js.map → sunburst-H57DYWLE.js.map} +0 -0
  831. /package/dist/{survival-3IECSQKM.js.map → survival-C26WPJFT.js.map} +0 -0
  832. /package/dist/{survival-TQZXLQMK.js.map → survival-PRHRAD2T.js.map} +0 -0
  833. /package/dist/{survival.integration.spec-IMLRYIX2.js.map → survival.integration.spec-KH6GPVZ4.js.map} +0 -0
  834. /package/dist/{svg2pdf.es.min-KKHWPFWG.js.map → svg2pdf.es.min-BRE45YLJ.js.map} +0 -0
  835. /package/dist/{svgraph-YE4MTHLA.js.map → svgraph-VVGRE672.js.map} +0 -0
  836. /package/dist/{svmr-KY3V2L4L.js.map → svmr-OKTQIHLN.js.map} +0 -0
  837. /package/dist/{swimmer-HO32NUCE.js.map → swimmer-U5COUOM6.js.map} +0 -0
  838. /package/dist/{table-6VZK2B2G.js.map → table-I7SINEY4.js.map} +0 -0
  839. /package/dist/{termCollection-AMV35ML5.js.map → termCollection-QCSPDISY.js.map} +0 -0
  840. /package/dist/{termCollection-ETWJLZJT.js.map → termCollection-TFNI2VIX.js.map} +0 -0
  841. /package/dist/{termCollection.unit.spec-QHKLFPWO.js.map → termCollection.unit.spec-22E76H2W.js.map} +0 -0
  842. /package/dist/{termCollectionFractionSelection-ZNMCUSN4.js.map → termCollectionFractionSelection-VZ5JJ7KV.js.map} +0 -0
  843. /package/dist/{termCollectionFractionSelection.unit.spec-PO4BHCMC.js.map → termCollectionFractionSelection.unit.spec-KCAQU2BV.js.map} +0 -0
  844. /package/dist/{tk-R6IBTAYE.js.map → tk-GBNB42AI.js.map} +0 -0
  845. /package/dist/{tk-7OE7QMYG.js.map → tk-YOBCGYFC.js.map} +0 -0
  846. /package/dist/{tp.ui-BGSBCIR7.js.map → tp.ui-OEL4S73T.js.map} +0 -0
  847. /package/dist/{tvs.categorical-RTSI5L6T.js.map → tvs.categorical-3X6CO5EA.js.map} +0 -0
  848. /package/dist/{tvs.condition-VBDUN33K.js.map → tvs.condition-YZQSSONN.js.map} +0 -0
  849. /package/dist/{tvs.dt-NP6556P7.js.map → tvs.dt-GCMLLAJC.js.map} +0 -0
  850. /package/dist/{tvs.dtcnv.categorical-RERJRI5J.js.map → tvs.dtcnv.categorical-ZSYUQQXP.js.map} +0 -0
  851. /package/dist/{tvs.dtcnv.continuous-UEVWYT3H.js.map → tvs.dtcnv.continuous-T67YFFAE.js.map} +0 -0
  852. /package/dist/{tvs.dtfusion-CRJ77JUK.js.map → tvs.dtfusion-VR2NAX3F.js.map} +0 -0
  853. /package/dist/{tvs.dtitd-ZOCNVICE.js.map → tvs.dtitd-O3MIZPZO.js.map} +0 -0
  854. /package/dist/{tvs.dtsnvindel-LFWG54AQ.js.map → tvs.dtsnvindel-6G7UNHSQ.js.map} +0 -0
  855. /package/dist/{tvs.dtsv-SNIZC3C6.js.map → tvs.dtsv-VZ2I4AMH.js.map} +0 -0
  856. /package/dist/{tvs.multivalue-UJS4743S.js.map → tvs.multivalue-6KFI5ELB.js.map} +0 -0
  857. /package/dist/{tvs.numeric-KKMUTKSJ.js.map → tvs.numeric-SFSOLXVF.js.map} +0 -0
  858. /package/dist/{tvs.samplelst-AW3IY3CB.js.map → tvs.samplelst-WD5UMMTP.js.map} +0 -0
  859. /package/dist/{tvs.survival-LH2Z3WTM.js.map → tvs.survival-A2RUXAXJ.js.map} +0 -0
  860. /package/dist/{tvs.termCollection-OQNMYVX5.js.map → tvs.termCollection-NVW4LO44.js.map} +0 -0
  861. /package/dist/{vocabulary-6XMG22NZ.js.map → vocabulary-FASF5IUM.js.map} +0 -0
  862. /package/dist/{wsi.direct-EJ2ENH64.js.map → wsi.direct-O6HFKPCP.js.map} +0 -0
@@ -0,0 +1,636 @@
1
+ import {
2
+ Map_default,
3
+ Tile_default,
4
+ View_default,
5
+ Zoomify_default,
6
+ addScaleBar
7
+ } from "./chunk-2RILGMXS.js";
8
+ import {
9
+ PlotBase,
10
+ Tabs,
11
+ controlsInit,
12
+ renderTable
13
+ } from "./chunk-3YQYWX4M.js";
14
+ import "./chunk-HJ6L54YS.js";
15
+ import "./chunk-R3RD3VEX.js";
16
+ import "./chunk-CNFTQSNE.js";
17
+ import "./chunk-RIHO7ZD5.js";
18
+ import "./chunk-TVJOSRCH.js";
19
+ import "./chunk-3CIL7KH7.js";
20
+ import "./chunk-T4XPCSLP.js";
21
+ import {
22
+ dofetch3
23
+ } from "./chunk-KBTFT76L.js";
24
+ import "./chunk-W5J3LTYS.js";
25
+ import "./chunk-MHWYRNGA.js";
26
+ import "./chunk-JHLF2ZC2.js";
27
+ import "./chunk-WJLRU5OF.js";
28
+ import {
29
+ copyMerge,
30
+ getCompInit
31
+ } from "./chunk-HBNB5TRH.js";
32
+ import "./chunk-PF4DSFDR.js";
33
+ import "./chunk-4OLM3KSB.js";
34
+ import "./chunk-PWYMHUXY.js";
35
+ import "./chunk-TLT4YIG3.js";
36
+ import "./chunk-5R63Q5KH.js";
37
+ import "./chunk-I6Y4O3RR.js";
38
+ import "./chunk-Q5RDQNIT.js";
39
+ import "./chunk-HS5PO5ZQ.js";
40
+
41
+ // plots/w2/model/Model.ts
42
+ var Model = class {
43
+ constructor(genome, dslabel) {
44
+ this.genome = genome;
45
+ this.dslabel = dslabel;
46
+ }
47
+ // both requests address the dataset
48
+ /** Every sample in the dataset that has at least one PLAIN slide on disk
49
+ (a wsiFolder subfolder with a slide), with plain-slide counts. Spatial-only
50
+ samples are not listed — spatial images are viewed through the sc app,
51
+ which fetches them per sample via getImages(). */
52
+ async getData() {
53
+ return await dofetch3("termdb/wsiBySample", {
54
+ body: { genome: this.genome, dslabel: this.dslabel }
55
+ // no sample_id = list samples
56
+ });
57
+ }
58
+ /** One sample's images (WsiImage | SpatialImage). imageType restricts the
59
+ enumeration to that root ('wsi' = wsiFolder, 'spatial' = folder) so the
60
+ other tree is never read; omitted = both kinds. */
61
+ async getImages(sample_id, imageType) {
62
+ return await dofetch3("termdb/wsiBySample", {
63
+ body: { genome: this.genome, dslabel: this.dslabel, sample_id, imageType }
64
+ // sample_id = list its images
65
+ });
66
+ }
67
+ };
68
+
69
+ // plots/w2/viewModel/ViewModel.ts
70
+ var ViewModel = class {
71
+ // built once in the constructor, read by View
72
+ constructor(samples, settings) {
73
+ this.viewData = {
74
+ columns: [{ label: "Sample" }, { label: "Images" }],
75
+ // two-column table
76
+ rows: samples.map((s) => [{ value: s.sampleId }, { value: String(s.count) }]),
77
+ // one row per sample
78
+ selectedSample: samples[settings.selectedSampleIndex]
79
+ // undefined when index is -1
80
+ };
81
+ }
82
+ };
83
+
84
+ // plots/w2/view/View.ts
85
+ var View = class {
86
+ constructor(dom, viewData, images, settings, interactions, vocab) {
87
+ this.dom = dom;
88
+ this.viewData = viewData;
89
+ this.images = images;
90
+ this.settings = settings;
91
+ this.interactions = interactions;
92
+ this.vocab = vocab;
93
+ }
94
+ async render() {
95
+ this.renderSampleTable();
96
+ await this.renderViewer();
97
+ }
98
+ renderSampleTable() {
99
+ this.dom.table.selectAll("*").remove();
100
+ renderTable({
101
+ div: this.dom.table,
102
+ // mount point
103
+ columns: this.viewData.columns,
104
+ // Sample | Images
105
+ rows: this.viewData.rows,
106
+ // one row per sample with images
107
+ singleMode: true,
108
+ // radio buttons: one sample viewed at a time
109
+ selectedRows: this.settings.selectedSampleIndex != -1 ? [this.settings.selectedSampleIndex] : [],
110
+ noButtonCallback: (index) => this.interactions.selectSample(index),
111
+ // row click = select sample
112
+ resize: true,
113
+ // user-resizable table
114
+ striped: true,
115
+ // alternating row shading
116
+ maxHeight: "30vh",
117
+ // table scrolls; the viewer keeps the space below
118
+ header: { style: { "text-transform": "capitalize" } }
119
+ // 'sample' -> 'Sample'
120
+ });
121
+ }
122
+ async renderViewer() {
123
+ const holder = this.dom.viewer;
124
+ holder.selectAll("*").remove();
125
+ const sample = this.viewData.selectedSample;
126
+ const selected = this.settings.selectedImageIndex;
127
+ const image = this.images[selected] ?? this.images[0];
128
+ if (!sample || !image) return;
129
+ const imageName = (f) => f.split("/").slice(-2)[0] || f;
130
+ new Tabs({
131
+ holder: holder.append("div"),
132
+ // tab strip sits above the map
133
+ tabsPosition: "horizontal",
134
+ tabs: this.images.map((img, i) => ({
135
+ label: imageName(img.fileName),
136
+ // e.g. 'image1'
137
+ active: i == (this.images[selected] ? selected : 0),
138
+ // highlight the shown image
139
+ callback: () => this.interactions.selectImage(i)
140
+ // dispatch -> re-render with image i
141
+ }))
142
+ }).main();
143
+ const params = `wsimage=${encodeURIComponent(image.fileName)}&dslabel=${this.vocab.dslabel}&genome=${this.vocab.genome}&sample_id=${encodeURIComponent(sample.sampleId)}&imageType=${image.type}`;
144
+ if (image.type == "spatial") {
145
+ const s = this.settings;
146
+ const genes = s.geneExpression ?? image.geneExpression;
147
+ const direct = await import("./wsi.direct-O6HFKPCP.js");
148
+ await direct.init(
149
+ {
150
+ slideQuery: params,
151
+ // addresses the slide through the dataset (no direct-path gate)
152
+ // lets the neighborhood-enrichment panel offer a similar-region
153
+ // search against the dataset's other spatial samples
154
+ genome: this.vocab.genome,
155
+ dslabel: this.vocab.dslabel,
156
+ sampleId: sample.sampleId,
157
+ label: image.fileName,
158
+ // display name in the info line
159
+ spatialData: image.spatialData,
160
+ // the consolidated h5ad, source of every overlay
161
+ hideCellStrokes: !s.showCellBoundaries,
162
+ // polygons without their green outlines
163
+ hideNucleusStrokes: !s.showNucleusBoundaries,
164
+ // skip the nucleus overlay entirely
165
+ showCellTypes: s.showCellTypes,
166
+ // fill cells by their cell_type annotation
167
+ cellTypeFilter: s.cellTypeFilter ?? void 0,
168
+ // 'Types shown' dropdowns; []/null = all
169
+ geneExpression: s.spatialMode == "gene_groups" ? void 0 : genes,
170
+ // one overlay per gene
171
+ geneGroups: s.spatialMode == "gene_groups" ? genes : void 0,
172
+ // or one summed overlay
173
+ hideExpressionFills: !s.showGeneExpression,
174
+ // checkbox off = hover counts only, no fills
175
+ annotationLevel: s.annotationLevel ?? image.annotationLevel,
176
+ // burger overrides dataset
177
+ cellCountLimit: s.cellCountLimit ?? void 0,
178
+ // null = wsi.direct.ts's own default
179
+ width: "100%",
180
+ // fill the sandbox
181
+ height: this.settings.viewerHeight
182
+ // e.g. 70vh
183
+ },
184
+ holder
185
+ );
186
+ return;
187
+ }
188
+ const meta = await dofetch3(`wsitiles/meta?${params}`);
189
+ if (!meta || meta.error || meta.status === "error") {
190
+ this.dom.error.text(`Error loading ${image.fileName}: ${meta?.error || "failed to load slide metadata"}`);
191
+ return;
192
+ }
193
+ const [w, h] = meta.slide_dimensions;
194
+ const host = (sessionStorage.getItem("hostURL") || window.testHost || "").replace(/\/+$/, "");
195
+ const source = new Zoomify_default({
196
+ // {z}/{x}/{y} hit wsitiles/tile; the unused {TileGroup} token only satisfies
197
+ // OpenLayers' requirement that a {TileGroup}/{tileIndex} placeholder be present.
198
+ // v=<slide mtime>: tiles are served immutable, so a regenerated slide must
199
+ // change the URL to bust the browser cache
200
+ url: `${host}/wsitiles/tile/{z}/{x}/{y}?${params}&v=${meta.version || 0}&_={TileGroup}`,
201
+ size: [w, h],
202
+ // OL derives the tier count from this, same math as wsi_tile.py
203
+ crossOrigin: "anonymous",
204
+ // tiles come from the API origin, not the page's
205
+ zDirection: -1
206
+ // pick the sharper tier when between two zoom levels
207
+ });
208
+ const grid = source.getTileGrid();
209
+ const extent = grid.getExtent();
210
+ const mapDiv = holder.append("div").style("width", "100%").style("height", this.settings.viewerHeight);
211
+ const map = new Map_default({
212
+ target: mapDiv.node(),
213
+ // mount the map into the plot's viewer div
214
+ layers: [new Tile_default({ source })],
215
+ // OL fetches+mosaics tiles as the user pans/zooms
216
+ view: new View_default({ resolutions: grid.getResolutions(), extent })
217
+ // camera locked to the pyramid
218
+ });
219
+ map.getView().fit(extent);
220
+ addScaleBar(map, Array.isArray(meta.mpp) && meta.mpp.length === 2 ? meta.mpp[0] : void 0);
221
+ }
222
+ };
223
+
224
+ // plots/w2/interactions/WsiInteractions.ts
225
+ var WsiInteractions = class {
226
+ constructor(app, id) {
227
+ this.app = app;
228
+ this.id = id;
229
+ }
230
+ // rx app + this plot's id, for dispatching
231
+ /** a sample row was picked in the table; image selection resets to its first image */
232
+ selectSample(index) {
233
+ this.app.dispatch({
234
+ type: "plot_edit",
235
+ id: this.id,
236
+ config: { settings: { wsi: { selectedSampleIndex: index, selectedImageIndex: 0 } } }
237
+ });
238
+ }
239
+ /** an image tab was picked for the selected sample */
240
+ selectImage(index) {
241
+ this.app.dispatch({
242
+ type: "plot_edit",
243
+ id: this.id,
244
+ config: { settings: { wsi: { selectedImageIndex: index } } }
245
+ });
246
+ }
247
+ };
248
+
249
+ // plots/w2/Wsi.ts
250
+ var Wsi = class _Wsi extends PlotBase {
251
+ constructor(opts, api) {
252
+ super(opts, api);
253
+ // created in init()
254
+ /** showCellTypes of the previous render, to tell which exclusive fill
255
+ checkbox was just toggled when both end up checked */
256
+ this.prevShowCellTypes = false;
257
+ /** gene names available in the current image's expression h5, cached per file */
258
+ this.geneNames = [];
259
+ /** cell types available in the current image's annotations CSV, cached per file */
260
+ this.cellTypeNames = [];
261
+ this.type = _Wsi.type;
262
+ const holder = opts.holder.classed("sjpp-wsi-main", true);
263
+ const div = holder.append("div").style("padding", "5px");
264
+ this.dom = {
265
+ div,
266
+ // burger menu for spatial viewer settings; hidden until a spatial image is shown
267
+ controls: div.append("div").attr("id", "sjpp-wsi-controls").style("display", "none"),
268
+ error: div.append("div").attr("id", "sjpp-wsi-error").style("opacity", 0.75),
269
+ // inline errors
270
+ table: div.append("div").attr("id", "sjpp-wsi-table"),
271
+ // sample table mount
272
+ viewer: div.append("div").attr("id", "sjpp-wsi-viewer")
273
+ // tabs + map mount
274
+ };
275
+ if (opts.header)
276
+ this.dom.header = opts.header.text("WHOLE SLIDE IMAGES").style("font-size", "0.7em").style("opacity", 0.6);
277
+ }
278
+ static {
279
+ this.type = "wsi";
280
+ }
281
+ /** the app-state slice this plot reacts to */
282
+ getState(appState) {
283
+ const config = appState.plots.find((p) => p.id === this.id);
284
+ if (!config) {
285
+ throw `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`;
286
+ }
287
+ return {
288
+ vocab: appState.vocab,
289
+ // genome + dslabel for server requests
290
+ config
291
+ // the plot's own settings
292
+ };
293
+ }
294
+ /** rx lifecycle: one-time setup before the first main() */
295
+ async init() {
296
+ this.interactions = new WsiInteractions(this.app, this.id);
297
+ }
298
+ /** rx lifecycle: re-renders the whole plot on every relevant state change */
299
+ async main() {
300
+ const config = structuredClone(this.state.config);
301
+ if (config.childType != this.type && config.chartType != this.type) return;
302
+ if (!this.interactions) throw "Interactions not initialized [wsi main()]";
303
+ const settings = config.settings.wsi;
304
+ if (settings.showCellTypes && settings.showGeneExpression) {
305
+ const off = this.prevShowCellTypes ? "showCellTypes" : "showGeneExpression";
306
+ this.app.dispatch({ type: "plot_edit", id: this.id, config: { settings: { wsi: { [off]: false } } } });
307
+ return;
308
+ }
309
+ this.prevShowCellTypes = settings.showCellTypes;
310
+ this.dom.error.text("");
311
+ const fixedSample = config.sample?.sID;
312
+ const fixedKind = config.imageType == "wsi" ? "wsi" : "spatial";
313
+ const model = new Model(this.state.vocab.genome, this.state.vocab.dslabel);
314
+ let samples;
315
+ if (fixedSample) {
316
+ this.dom.table.style("display", "none");
317
+ settings.selectedSampleIndex = 0;
318
+ samples = [{ sampleId: fixedSample, count: 1 }];
319
+ } else {
320
+ const data = await model.getData();
321
+ if (!data || data.error || !data.samples?.length) {
322
+ this.dom.table.selectAll("*").remove();
323
+ this.dom.viewer.selectAll("*").remove();
324
+ this.dom.error.style("padding", "20px").text(data?.error || "No samples with whole-slide images.");
325
+ return;
326
+ }
327
+ samples = data.samples;
328
+ }
329
+ const viewModel = new ViewModel(samples, settings);
330
+ const selectedSample = viewModel.viewData.selectedSample;
331
+ const imageData = selectedSample ? await model.getImages(selectedSample.sampleId, fixedSample ? fixedKind : "wsi") : void 0;
332
+ if (imageData?.error) throw new Error(imageData.error);
333
+ const images = imageData?.images ?? [];
334
+ if (fixedSample && !images.length) {
335
+ this.dom.viewer.selectAll("*").remove();
336
+ this.dom.error.style("padding", "20px").text(`No ${fixedKind == "spatial" ? "spatial image" : "whole-slide image"} for sample ${fixedSample}.`);
337
+ return;
338
+ }
339
+ const image = images[settings.selectedImageIndex] ?? images[0];
340
+ const isSpatial = image?.type == "spatial";
341
+ this.dom.header?.text(isSpatial ? "SPATIAL VIEWER" : "WHOLE SLIDE IMAGES");
342
+ if (isSpatial) {
343
+ const spImage = image;
344
+ const genes = await this.fetchGeneNames(spImage, selectedSample.sampleId);
345
+ const cellTypes = await this.fetchCellTypes(spImage, selectedSample.sampleId);
346
+ if (settings.cellTypeFilter?.length && cellTypes.length) {
347
+ const cleaned = settings.cellTypeFilter.filter((t) => cellTypes.includes(t));
348
+ if (cleaned.length != settings.cellTypeFilter.length) {
349
+ this.app.dispatch({
350
+ type: "plot_edit",
351
+ id: this.id,
352
+ config: { settings: { wsi: { cellTypeFilter: cleaned } } }
353
+ });
354
+ return;
355
+ }
356
+ }
357
+ if (settings.geneExpression == null) {
358
+ const configured = (spImage.geneExpression || "").split(",").map((s) => s.trim()).filter((g) => genes.includes(g));
359
+ this.app.dispatch({
360
+ // one-time seeding edit; triggers a re-render with the seeded values
361
+ type: "plot_edit",
362
+ id: this.id,
363
+ config: {
364
+ settings: {
365
+ wsi: {
366
+ geneExpression: configured.join(",") || genes[0] || "",
367
+ annotationLevel: settings.annotationLevel ?? spImage.annotationLevel,
368
+ // dataset default (w2.cellTypes); the burger checkbox overrides
369
+ // after. Fills are mutually exclusive, so cell types on means
370
+ // expression fills off (hover counts stay either way)
371
+ showCellTypes: spImage.cellTypes ?? settings.showCellTypes,
372
+ showGeneExpression: spImage.cellTypes ? false : settings.showGeneExpression
373
+ }
374
+ }
375
+ }
376
+ });
377
+ return;
378
+ }
379
+ if (!this.components.controls) await this.setControls();
380
+ this.addGeneDatalist();
381
+ }
382
+ this.dom.controls.style("display", isSpatial ? "inline-block" : "none");
383
+ await new View(this.dom, viewModel.viewData, images, settings, this.interactions, this.state.vocab).render();
384
+ }
385
+ // the h5 the cache was built from
386
+ /** Discover the genes present in the image's cell_feature_matrix h5 via
387
+ wsitiles/genenames (same slide-scoped access checks as genecounts).
388
+ Returns [] when the image has no expression file or the request fails. */
389
+ async fetchGeneNames(image, sampleId) {
390
+ const src = image.spatialData;
391
+ if (!src) return [];
392
+ if (this.geneNamesFile == src) return this.geneNames;
393
+ const v = this.state.vocab;
394
+ const params = (
395
+ // standard wsitiles slide addressing + the expression file
396
+ `wsimage=${encodeURIComponent(image.fileName)}&dslabel=${v.dslabel}&genome=${v.genome}&sample_id=${encodeURIComponent(sampleId)}&imageType=spatial&file=${encodeURIComponent(src)}`
397
+ );
398
+ const r = await dofetch3(`wsitiles/genenames?${params}`).catch(() => null);
399
+ this.geneNames = Array.isArray(r?.genes) ? r.genes : [];
400
+ this.geneNamesFile = src;
401
+ return this.geneNames;
402
+ }
403
+ // the CSV the cache was built from
404
+ /** Discover the distinct cell_type values of the image's per-cell
405
+ annotations CSV via the meta request (?cellAnnotations= makes
406
+ wsitiles/meta scan it). Returns [] when the image has no annotations
407
+ file or the request fails. */
408
+ async fetchCellTypes(image, sampleId) {
409
+ const src = image.spatialData;
410
+ if (!src) {
411
+ this.cellTypeNames = [];
412
+ this.cellTypesFile = void 0;
413
+ return this.cellTypeNames;
414
+ }
415
+ if (this.cellTypesFile == src) return this.cellTypeNames;
416
+ const v = this.state.vocab;
417
+ const params = (
418
+ // standard wsitiles slide addressing + the annotations source to scan
419
+ `wsimage=${encodeURIComponent(image.fileName)}&dslabel=${v.dslabel}&genome=${v.genome}&sample_id=${encodeURIComponent(sampleId)}&imageType=spatial&cellAnnotations=${encodeURIComponent(src)}`
420
+ );
421
+ const r = await dofetch3(`wsitiles/meta?${params}`).catch(() => null);
422
+ this.cellTypeNames = Array.isArray(r?.cellTypes) ? r.cellTypes : [];
423
+ this.cellTypesFile = src;
424
+ return this.cellTypeNames;
425
+ }
426
+ /** Attach the discovered gene names to the Genes text input as a native
427
+ datalist, so typing autocompletes to genes that exist in the data.
428
+ (Autocomplete applies to the whole field, i.e. the first gene of a
429
+ comma-separated list — later genes are typed without suggestions.) */
430
+ addGeneDatalist() {
431
+ if (!this.geneNames.length) return;
432
+ const input = this.dom.controls.select("input[type=text]").node();
433
+ if (!input) return;
434
+ const id = `sjpp-wsi-genes-${this.id}`;
435
+ document.getElementById(id)?.remove();
436
+ const dl = document.createElement("datalist");
437
+ dl.id = id;
438
+ for (const g of this.geneNames) {
439
+ const opt = document.createElement("option");
440
+ opt.value = g;
441
+ dl.appendChild(opt);
442
+ }
443
+ input.after(dl);
444
+ input.setAttribute("list", id);
445
+ }
446
+ /** Burger menu with the spatial overlay settings; fields are pre-seeded
447
+ with defaults discovered from the data by main() before this runs. */
448
+ async setControls() {
449
+ this.components.controls = await controlsInit({
450
+ app: this.app,
451
+ // rx app the inputs dispatch through
452
+ id: this.id,
453
+ // this plot's id in app state
454
+ holder: this.dom.controls,
455
+ // the burger-menu div
456
+ inputs: [
457
+ {
458
+ // checkbox: toggle the blue nucleus outlines
459
+ label: "Nucleus boundaries",
460
+ title: "Show or hide the nucleus segmentation overlay",
461
+ type: "checkbox",
462
+ chartType: "wsi",
463
+ settingsKey: "showNucleusBoundaries",
464
+ boxLabel: "show"
465
+ },
466
+ {
467
+ // checkbox: toggle the green cell outlines
468
+ label: "Cell boundaries",
469
+ title: "Show or hide the cell segmentation overlay",
470
+ type: "checkbox",
471
+ chartType: "wsi",
472
+ settingsKey: "showCellBoundaries",
473
+ boxLabel: "show"
474
+ },
475
+ {
476
+ // checkbox: toggle the categorical cell-type fills (mutually
477
+ // exclusive with the gene expression fills, enforced in main())
478
+ label: "Cell types",
479
+ title: "Fill cells by their cell_type from the annotations CSV (when present)",
480
+ type: "checkbox",
481
+ chartType: "wsi",
482
+ settingsKey: "showCellTypes",
483
+ boxLabel: "show"
484
+ },
485
+ {
486
+ // chained dropdowns: one per selected type, plus an add-dropdown of
487
+ // the remaining types that appears once the previous is picked.
488
+ // No selection = all types. Hidden when the overlay is off or the
489
+ // image's CSV has no cell_type column.
490
+ label: "Types shown",
491
+ title: "Fill only the selected cell types; no selection = all types",
492
+ type: "custom",
493
+ settingsKey: "cellTypeFilter",
494
+ init: (self) => ({
495
+ main: (plot) => {
496
+ const td = self.dom.inputTd;
497
+ td.selectAll("*").remove();
498
+ const types = this.cellTypeNames;
499
+ const s = plot.settings.wsi;
500
+ if (!s.showCellTypes || !types.length) {
501
+ self.dom.row.style("display", "none");
502
+ return;
503
+ }
504
+ self.dom.row.style("display", "table-row");
505
+ const selected = (s.cellTypeFilter || []).filter((t) => types.includes(t));
506
+ const dispatch = (list) => (
507
+ // write the new selection back to state; re-render redraws the
508
+ // dropdowns. Stored as a LIST: type names are free text and may
509
+ // contain commas, so a joined string would corrupt them
510
+ this.app.dispatch({
511
+ type: "plot_edit",
512
+ id: this.id,
513
+ config: { settings: { wsi: { cellTypeFilter: list } } }
514
+ })
515
+ );
516
+ const addSelect = () => td.append("select").attr("aria-label", "Cell type filter").style("display", "block").style("margin", "2px 0").style("max-width", "180px");
517
+ for (const [i, t] of selected.entries()) {
518
+ const sel = addSelect().on("change", function() {
519
+ const next = selected.slice();
520
+ if (this.value) next[i] = this.value;
521
+ else next.splice(i, 1);
522
+ dispatch(next);
523
+ });
524
+ sel.append("option").attr("value", "").text("\xD7 remove");
525
+ for (const ty of types)
526
+ if (ty == t || !selected.includes(ty))
527
+ sel.append("option").attr("value", ty).property("selected", ty == t).text(ty);
528
+ }
529
+ const remaining = types.filter((ty) => !selected.includes(ty));
530
+ if (remaining.length) {
531
+ const add = addSelect().on("change", function() {
532
+ if (this.value) dispatch([...selected, this.value]);
533
+ });
534
+ add.append("option").attr("value", "").text(selected.length ? "Add type\u2026" : "All types");
535
+ for (const ty of remaining) add.append("option").attr("value", ty).text(ty);
536
+ }
537
+ }
538
+ })
539
+ },
540
+ {
541
+ // checkbox: toggle the expression FILLS only — hover counts stay
542
+ // either way (View.ts always loads the genes)
543
+ label: "Gene expression",
544
+ title: "Show or hide the gene expression overlay",
545
+ type: "checkbox",
546
+ chartType: "wsi",
547
+ settingsKey: "showGeneExpression",
548
+ boxLabel: "show"
549
+ },
550
+ {
551
+ // text field: which genes to load, with datalist autocomplete
552
+ label: "Genes",
553
+ title: "Comma-separated gene names to overlay",
554
+ type: "text",
555
+ chartType: "wsi",
556
+ settingsKey: "geneExpression",
557
+ placeholder: "gene1,gene2,\u2026"
558
+ },
559
+ {
560
+ // radio: per-gene overlays vs one summed gene-group overlay
561
+ label: "Overlay mode",
562
+ title: "Color each gene separately (gene_expression), or sum all genes into one overlay (gene_groups)",
563
+ type: "radio",
564
+ chartType: "wsi",
565
+ settingsKey: "spatialMode",
566
+ options: [
567
+ { label: "Per gene", value: "gene_expression" },
568
+ { label: "Gene group", value: "gene_groups" }
569
+ ]
570
+ },
571
+ {
572
+ // number: how many zoomed-in levels show the boundary strokes
573
+ label: "Annotation level",
574
+ title: "Show boundaries only within the n most zoomed-in levels; 0 = always show",
575
+ type: "number",
576
+ chartType: "wsi",
577
+ settingsKey: "annotationLevel",
578
+ min: 0,
579
+ step: 1
580
+ }
581
+ ]
582
+ });
583
+ }
584
+ };
585
+ var wsiInit = getCompInit(Wsi);
586
+ var componentInit = wsiInit;
587
+ function getDefaultWsiSettings(overrides = {}) {
588
+ const defaults = {
589
+ selectedSampleIndex: 0,
590
+ // first sample selected on launch
591
+ selectedImageIndex: 0,
592
+ // the sample's first image displayed by default
593
+ viewerHeight: "70vh",
594
+ // map height in the sandbox
595
+ // spatial overlay settings; null = fall back to the dataset's values
596
+ showCellBoundaries: true,
597
+ // green cell outlines on
598
+ showNucleusBoundaries: true,
599
+ // blue nucleus outlines on
600
+ showGeneExpression: true,
601
+ // expression fills on (seeding may flip this off)
602
+ showCellTypes: false,
603
+ // opt-in: fills all annotated cells, visually heavy
604
+ cellTypeFilter: null,
605
+ // null/[] = fill every annotated type
606
+ geneExpression: null,
607
+ // null = seed from the data on first spatial render
608
+ annotationLevel: null,
609
+ // null = dataset default
610
+ cellCountLimit: null,
611
+ // null = wsi.direct.ts's own default
612
+ spatialMode: "gene_expression"
613
+ // per-gene overlays by default
614
+ };
615
+ return Object.assign(defaults, overrides);
616
+ }
617
+ async function getPlotConfig(opts, _app) {
618
+ const config = {
619
+ chartType: "wsi",
620
+ // routes state updates to this component
621
+ settings: {
622
+ wsi: getDefaultWsiSettings(opts.overrides)
623
+ // defaults + dataset overrides
624
+ },
625
+ hidePlotFilter: true
626
+ // the mass filter UI doesn't apply to slides
627
+ };
628
+ return copyMerge(config, opts);
629
+ }
630
+ export {
631
+ componentInit,
632
+ getDefaultWsiSettings,
633
+ getPlotConfig,
634
+ wsiInit
635
+ };
636
+ //# sourceMappingURL=Wsi-CC7GX3HL.js.map