@sjcrh/proteinpaint-client 2.222.0 → 2.223.0

package/dist/chunk-MU7GTJYA.js

@@ -1,1219 +0,0 @@
-import {
-  cohortMatches
-} from "./chunk-ZX75ZAUG.js";
-import {
-  BRAIN_P_THRESHOLD,
-  brainFillByRegion,
-  brainTooltipByRegion,
-  loadBrainAssets,
-  makeBrainFcScale,
-  makeDiseaseTabs,
-  renderBrainSvg
-} from "./chunk-ILEXRHF7.js";
-import {
-  axisstyle,
-  table2col
-} from "./chunk-4ASBDE27.js";
-import {
-  Menu
-} from "./chunk-CNFTQSNE.js";
-import {
-  dofetch3
-} from "./chunk-4TJO2DGU.js";
-import {
-  NumericModes
-} from "./chunk-JHLF2ZC2.js";
-import {
-  axisBottom,
-  axisLeft,
-  line_default
-} from "./chunk-WJLRU5OF.js";
-import {
-  band,
-  linear,
-  point,
-  sqrt
-} from "./chunk-4OLM3KSB.js";
-import {
-  roundValue
-} from "./chunk-TLT4YIG3.js";
-import {
-  select_default
-} from "./chunk-I6Y4O3RR.js";
-
-// plots/proteinView.tiles.ts
-function getProteinViewConfig(self) {
-  return self?.app?.vocabApi?.termdbConfig?.queries?.proteome?.proteinView || {};
-}
-function getTileConfigs(self) {
-  return getProteinViewConfig(self).tiles || [];
-}
-function getTileConfig(self, key) {
-  return getTileConfigs(self).find((t) => t.key === key);
-}
-function diseaseCfg(self) {
-  return getProteinViewConfig(self).diseases || {};
-}
-var diseaseOrder = (self) => Object.keys(diseaseCfg(self));
-var diseaseLabel = (self, d) => diseaseCfg(self)[d]?.label || d;
-var isSpecificityControl = (self, d) => !!diseaseCfg(self)[d]?.specificityControl;
-var modelOrder = (self) => Object.keys(getProteinViewConfig(self).models || {});
-var modelColor = (self, m) => getProteinViewConfig(self).models?.[m]?.color || SINGLE_MODEL_COLOR;
-var cellTypeCfg = (self) => getProteinViewConfig(self).cellTypes || {};
-var proteomeLabel = (self, organism, assay) => self?.app?.vocabApi?.termdbConfig?.queries?.proteome?.organisms?.[organism]?.assays?.[assay]?.proteomeLabel || assay;
-function orderBy(keys, order) {
-  const rank = (k) => order.indexOf(k) === -1 ? order.length : order.indexOf(k);
-  return [...keys].sort((a, b) => rank(a) - rank(b));
-}
-var SIG_P = 0.05;
-function parseAge(ageGroup) {
-  const n = parseInt(ageGroup || "");
-  return Number.isFinite(n) ? n : null;
-}
-var byAge = (a, b) => (parseAge(a) ?? 0) - (parseAge(b) ?? 0);
-var fetchCache = /* @__PURE__ */ new Map();
-function cachedFetch(key, load) {
-  if (!fetchCache.has(key)) {
-    const p = load();
-    p.catch(() => fetchCache.delete(key));
-    fetchCache.set(key, p);
-  }
-  return fetchCache.get(key);
-}
-var vocabKey = (self) => `${self.app.opts.state.vocab.genome}|${self.app.opts.state.vocab.dslabel}`;
-var TILE_FACE_SCALE = 0.67;
-var TILE_FACE_SCALE_X = 0.45;
-var EXPANDED_SCALE = 1.7;
-var CARD_W = 230;
-var CARD_MIN_H = 235;
-var SINGLE_MODEL_COLOR = "#6b7280";
-var ND_COLOR = "#4263eb";
-var PSY_COLOR = "#9ca3af";
-var WHOLE_COLOR = "#2166ac";
-var INSOLUBLE_COLOR = "#b2182b";
-var REFERENCE_COLOR = "#111827";
-var FC_NEG_COLOR = "#762a83";
-var FC_ZERO_COLOR = "#f7f7f7";
-var FC_POS_COLOR = "#2166ac";
-function getLog2Ratio(foldChange) {
-  if (!Number.isFinite(foldChange) || foldChange <= 0) return null;
-  return Math.log2(foldChange);
-}
-function launchViolinPlot(self, organismName, assayName, cohortName, isoform) {
-  const selectedProtein = self.state.config?.tw?.term;
-  if (!selectedProtein) throw new Error("proteinView: selected protein term is missing");
-  const action = {
-    type: "plot_create",
-    config: {
-      chartType: "summary"
-    }
-  };
-  action.config.assayCohortTitle = `${organismName} ${assayName}: ${cohortName}`;
-  action.config.proteomeDetails = { organism: organismName, assay: assayName, cohort: cohortName };
-  const termdbConfig = self.app.vocabApi.termdbConfig;
-  const proteomeOverlayTerm = termdbConfig?.queries?.proteome?.organisms?.[organismName]?.overlayTerm;
-  const t = structuredClone(selectedProtein);
-  t.name = `${t.name}: ${isoform}`;
-  t.dataTypeDetails = { organism: organismName, assay: assayName, cohort: cohortName };
-  action.config.term = { term: t, q: { mode: NumericModes.continuous } };
-  if (proteomeOverlayTerm) {
-    action.config.term2 = { term: structuredClone(proteomeOverlayTerm), q: {} };
-  }
-  self.app.dispatch(action);
-}
-var entries = (td, key) => td.byTile[key] || [];
-function catalogForEntry(self, e) {
-  return self.app.vocabApi.termdbConfig?.queries?.proteome?.organisms?.[e.organism]?.assays?.[e.assayName]?.cohorts?.[e.cohortName]?.catalog;
-}
-function prepareTileData(data, self) {
-  const catalogFor = (e) => catalogForEntry(self, e);
-  const accessions = /* @__PURE__ */ new Set();
-  let ptmSiteCount = 0;
-  const byCohort = /* @__PURE__ */ new Map();
-  for (const e of data?.cohorts || []) {
-    if (e.PTMType) {
-      ptmSiteCount++;
-      continue;
-    }
-    accessions.add(e.proteinAccession);
-    const log2fc = getLog2Ratio(e.foldChange);
-    if (log2fc === null) continue;
-    const key = `${e.organism}|${e.assayName}|${e.cohortName}`;
-    const p = Number(e.fdr);
-    const pRank = Number.isFinite(p) && p > 0 ? p : Infinity;
-    const cur = byCohort.get(key);
-    if (!cur) byCohort.set(key, { best: { e, pRank }, count: 1 });
-    else {
-      cur.count++;
-      if (pRank < cur.best.pRank) cur.best = { e, pRank };
-    }
-  }
-  const tiles = getTileConfigs(self);
-  const td = {
-    byTile: Object.fromEntries(tiles.map((t) => [t.key, []])),
-    isoformCount: accessions.size,
-    ptmSiteCount,
-    cohortCount: byCohort.size
-  };
-  for (const { best, count } of byCohort.values()) {
-    const e = best.e;
-    const catalog = catalogFor(e);
-    if (!catalog) continue;
-    const p = Number(e.fdr);
-    const entry = {
-      organism: e.organism,
-      assayName: e.assayName,
-      cohortName: e.cohortName,
-      disease: catalog.disease || e.disease,
-      uniqueIdentifier: e.uniqueIdentifier,
-      proteinAccession: e.proteinAccession,
-      log2fc: getLog2Ratio(e.foldChange),
-      fdr: Number.isFinite(p) && p > 0 ? p : null,
-      testedN: Number(e.testedN) || 0,
-      controlN: Number(e.controlN) || 0,
-      isoformCount: count,
-      catalog
-    };
-    const tile = tiles.find((t) => cohortMatches(t.cohortMatch, e.organism, e.assayName, catalog));
-    if (tile) td.byTile[tile.key].push(entry);
-  }
-  return td;
-}
-var CARD_OUTER_W = CARD_W + 26;
-function makeTileGrid(holder) {
-  return holder.append("div").style("display", "grid").style("grid-template-columns", `repeat(auto-fill, ${CARD_OUTER_W}px)`).style("grid-auto-flow", "row dense").style("gap", "14px").style("margin-top", "10px").style("white-space", "normal");
-}
-var expandedInGrid = /* @__PURE__ */ new WeakMap();
-var NO_EXPAND_SELECTOR = 'button,select,input,textarea,label,a,[role="button"],[role="tab"],[data-no-expand]';
-function tileExpandState(self, key) {
-  return {
-    open: self.expandedTileKey === key,
-    onToggle: (open) => {
-      if (open) self.expandedTileKey = key;
-      else if (self.expandedTileKey === key) self.expandedTileKey = null;
-    }
-  };
-}
-function makeTileCard(grid, opts) {
-  const card = grid.append("div").style("border", opts.disabled ? "1px dashed #e5e7eb" : "1px solid #e5e7eb").style("border-radius", "8px").style("padding", "10px 12px").style("background", opts.disabled ? "#f9fafb" : "#fff").style("min-width", "0");
-  if (opts.fullWidth) card.style("grid-column", "1 / -1");
-  if (opts.uniform) {
-    card.style("width", `${CARD_W}px`).style("min-height", `${CARD_MIN_H}px`).style("display", "flex").style("flex-direction", "column");
-  }
-  const header = card.append("div").style("display", "flex").style("align-items", "baseline").style("gap", "8px").style("flex-wrap", "wrap");
-  header.append("span").style("font-weight", "600").style("font-size", ".9em").style("min-width", "0").style("color", opts.disabled ? "#9ca3af" : "#111827").text(opts.title);
-  if (opts.subtitle) {
-    card.append("div").style("font-size", ".75em").style("color", "#6b7280").style("margin", "2px 0 4px 0").text(opts.subtitle);
-  }
-  const face = card.append("div");
-  const expand = opts.expand;
-  if (!expand) return face;
-  const expandedBody = card.append("div").style("display", "none").style("overflow-x", "auto");
-  const gridNode = grid.node();
-  let isOpen = false;
-  const toggleBtn = header.append("span").attr("role", "button").attr("tabindex", "0").style("margin-left", "auto").style("cursor", "pointer").style("color", "#9ca3af").style("font-size", "1em").style("line-height", "1").on("mouseover", function() {
-    select_default(this).style("color", "#374151");
-  }).on("mouseout", function() {
-    select_default(this).style("color", "#9ca3af");
-  });
-  const setToggleBtn = () => toggleBtn.text(isOpen ? "\u2921" : "\u2922").attr("title", isOpen ? "Collapse" : "Expand").attr("aria-label", `${isOpen ? "Collapse" : "Expand"} ${opts.title}`).attr("aria-expanded", String(isOpen));
-  setToggleBtn();
-  const collapse = () => {
-    if (!isOpen) return;
-    isOpen = false;
-    if (expandedInGrid.get(gridNode) === collapse) expandedInGrid.delete(gridNode);
-    const bodyNode = expandedBody.node();
-    bodyNode.replaceChildren();
-    expandedBody.style("display", "none");
-    face.style("display", null);
-    card.style("grid-column", opts.fullWidth ? "1 / -1" : null).style("cursor", "pointer");
-    if (opts.uniform) card.style("width", `${CARD_W}px`).style("min-height", `${CARD_MIN_H}px`);
-    setToggleBtn();
-    expand.onToggle?.(false);
-  };
-  const open = (scroll) => {
-    if (isOpen) return;
-    expandedInGrid.get(gridNode)?.();
-    isOpen = true;
-    expandedInGrid.set(gridNode, collapse);
-    face.style("display", "none");
-    card.style("grid-column", "1 / -1").style("width", null).style("min-height", null).style("cursor", null);
-    expandedBody.style("display", null);
-    expandedBody.node().replaceChildren();
-    setToggleBtn();
-    expand.onToggle?.(true);
-    const holder = expandedBody.append("div").style("padding", "4px 4px 0 4px");
-    try {
-      const p = expand.render(holder);
-      if (p instanceof Promise) {
-        const wait = holder.append("div").style("color", "#6b7280").style("font-size", ".85em").text("Loading\u2026");
-        p.catch((err) => renderTileError(holder, err, null)).finally(() => wait.remove());
-      }
-    } catch (err) {
-      renderTileError(holder, err, null);
-    }
-    if (scroll) card.node().scrollIntoView?.({ block: "nearest", behavior: "smooth" });
-  };
-  toggleBtn.on("click", (event) => {
-    event.stopPropagation();
-    if (isOpen) collapse();
-    else open(true);
-  }).on("keydown", (event) => {
-    if (event.key === "Enter" || event.key === " ") {
-      event.preventDefault();
-      if (isOpen) collapse();
-      else open(true);
-    }
-  });
-  card.style("cursor", "pointer").on("click", (event) => {
-    if (isOpen) return;
-    const t = event.target;
-    if (t?.closest?.(NO_EXPAND_SELECTOR)) return;
-    open(true);
-  });
-  if (expand.open) queueMicrotask(() => open(false));
-  return face;
-}
-var tileClickMenu = new Menu({ padding: "0px" });
-function entryTipTable(entry, holder) {
-  const tbl = table2col({ holder: holder.append("table") });
-  tbl.addRow("Sample set", entry.cohortName);
-  const c = entry.catalog || {};
-  if (entry.disease) tbl.addRow("Disease", entry.disease);
-  if (c.model) tbl.addRow("Model", c.model);
-  if (c.cellType) tbl.addRow("Cell type", c.cellType);
-  if (c.ageGroup) tbl.addRow("Age group", c.ageGroup);
-  if (c.sampleSource) tbl.addRow("Sample source", c.sampleSource);
-  if (entry.ptmType) tbl.addRow("PTM type", entry.ptmType);
-  if (entry.modSites) tbl.addRow("Modified site", entry.modSites);
-  tbl.addRow("Assay", entry.assayName);
-  tbl.addRow("log2 fold change", entry.log2fc === null ? "NA" : roundValue(entry.log2fc, 3));
-  tbl.addRow("FDR", entry.fdr === null ? "NA" : entry.fdr.toExponential(2));
-  tbl.addRow("Case samples", entry.testedN);
-  tbl.addRow("Control samples", entry.controlN);
-  tbl.addRow("Protein accession", entry.proteinAccession);
-  if (entry.isoformCount > 1) tbl.addRow("Note", `most significant of ${entry.isoformCount} isoforms`);
-}
-function attachEntryBehavior(shape, entry, self) {
-  shape.style("cursor", "pointer").on("mouseover", (event) => {
-    self.dom.tip.clear();
-    entryTipTable(entry, self.dom.tip.d);
-    self.dom.tip.show(event.clientX, event.clientY);
-  }).on("mouseout", () => self.dom.tip.hide()).on("click", (event) => {
-    event.stopPropagation();
-    self.dom.tip.hide();
-    tileClickMenu.clear();
-    const div = tileClickMenu.d.append("div");
-    entryTipTable(entry, div.append("div").style("padding", "5px"));
-    div.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Violin plot").on("click", () => {
-      tileClickMenu.hide();
-      launchViolinPlot(self, entry.organism, entry.assayName, entry.cohortName, entry.uniqueIdentifier);
-    });
-    tileClickMenu.show(event.clientX, event.clientY);
-  });
-}
-var isSig = (e) => e.fdr !== null && e.fdr < SIG_P;
-function drawMarker(g, x, y, color, sig, r = 4.5) {
-  return g.append("circle").attr("cx", x).attr("cy", y).attr("r", r).attr("fill", sig ? color : "#fff").attr("fill-opacity", sig ? 0.9 : 1).attr("stroke", color).attr("stroke-width", 1.5);
-}
-function fcDomain(values) {
-  let min = Math.min(0, ...values);
-  let max = Math.max(0, ...values);
-  const span = Math.max(0.4, max - min);
-  const pad = span * 0.15;
-  if (min < 0) min -= pad;
-  max += pad;
-  if (min === 0) min = -span * 0.05;
-  return [min, max];
-}
-function addSigFootnote(body) {
-  body.append("div").style("font-size", ".7em").style("color", "#9ca3af").style("margin-top", "2px").text(`filled: FDR < ${SIG_P}; hollow: not significant`);
-}
-function drawZeroLine(g, x1, y1, x2, y2) {
-  g.append("line").attr("x1", x1).attr("y1", y1).attr("x2", x2).attr("y2", y2).attr("stroke", "black").attr("stroke-dasharray", "4 3").attr("stroke-opacity", 0.35);
-}
-function styledAxis(g, axis, tickFontSize) {
-  const a = g.call(axis);
-  axisstyle({ axis: a, color: "black", showline: true });
-  if (tickFontSize) a.selectAll("text").style("font-size", tickFontSize);
-  return a;
-}
-function rotateXTicks(axisG) {
-  axisG.selectAll("text").attr("transform", "rotate(-38)").attr("text-anchor", "end").attr("dx", "-2px").attr("dy", "5px");
-}
-function yAxisTitle(svg, innerH, marginTop, text) {
-  svg.append("text").attr("transform", `translate(11,${marginTop + innerH / 2}) rotate(-90)`).attr("text-anchor", "middle").style("font-size", "11px").style("fill", "#374151").text(text);
-}
-function renderCrossDiseaseTile(body, td, self, cfg, opts = {}) {
-  const k = opts.scale || 1;
-  const kx = opts.scaleX ?? k;
-  const mr = 4.5 * Math.sqrt(k);
-  const tickFont = k < 1 ? "8.5px" : null;
-  const byDisease = /* @__PURE__ */ new Map();
-  const multiCohort = /* @__PURE__ */ new Set();
-  for (const e of entries(td, cfg.key)) {
-    const d = e.disease || e.cohortName;
-    const cur = byDisease.get(d);
-    if (cur) multiCohort.add(d);
-    if (!cur || (e.fdr ?? Infinity) < (cur.fdr ?? Infinity)) byDisease.set(d, e);
-  }
-  const diseases = orderBy([...byDisease.keys()], diseaseOrder(self));
-  const isControl = (d) => isSpecificityControl(self, d);
-  const margin = { top: 12, right: 10, bottom: 34, left: 46 };
-  const innerW = Math.max(200, diseases.length * 38) * kx;
-  const innerH = 150 * k;
-  const svg = body.append("svg").attr("width", innerW + margin.left + margin.right).attr("height", innerH + margin.top + margin.bottom);
-  const g = svg.append("g").attr("transform", `translate(${margin.left},${margin.top})`);
-  const x = band().domain(diseases).range([0, innerW]).padding(0.4);
-  const y = linear().domain(fcDomain(diseases.map((d) => byDisease.get(d).log2fc))).range([innerH, 0]);
-  const xAxisG = styledAxis(g.append("g").attr("transform", `translate(0,${innerH})`), axisBottom(x), tickFont);
-  if (kx < 0.6) rotateXTicks(xAxisG);
-  styledAxis(g.append("g"), axisLeft(y).ticks(4), tickFont);
-  drawZeroLine(g, 0, y(0), innerW, y(0));
-  yAxisTitle(svg, innerH, margin.top, "log2FC vs control");
-  const firstPsy = diseases.findIndex(isControl);
-  if (firstPsy > 0) {
-    const xSep = (x(diseases[firstPsy - 1]) + x.bandwidth() + x(diseases[firstPsy])) / 2;
-    g.append("line").attr("x1", xSep).attr("x2", xSep).attr("y1", 0).attr("y2", innerH).attr("stroke", "#d1d5db").attr("stroke-dasharray", "2 3");
-    if (kx >= 0.6) {
-      g.append("text").attr("x", (xSep + innerW) / 2).attr("y", 9).attr("text-anchor", "middle").style("font-size", "9px").style("fill", "#9ca3af").text(getProteinViewConfig(self).specificityControlLabel || "controls");
-    }
-  }
-  for (const d of diseases) {
-    const e = byDisease.get(d);
-    const cx = x(d) + x.bandwidth() / 2;
-    const color = isControl(d) ? PSY_COLOR : ND_COLOR;
-    g.append("line").attr("x1", cx).attr("x2", cx).attr("y1", y(0)).attr("y2", y(e.log2fc)).attr("stroke", color).attr("stroke-width", 1.5);
-    attachEntryBehavior(drawMarker(g, cx, y(e.log2fc), color, isSig(e), mr), e, self);
-  }
-  g.selectAll("text").each(function() {
-    const t = this.textContent || "";
-    const l = diseaseLabel(self, t);
-    if (l !== t) this.textContent = l;
-  });
-  addSigFootnote(body);
-  if (multiCohort.size) {
-    body.append("div").style("font-size", ".7em").style("color", "#9ca3af").text(`${[...multiCohort].map((d) => diseaseLabel(self, d)).join(", ")}: several cohorts, most significant shown`);
-  }
-  if (opts.expanded) {
-    body.append("div").style("font-size", ".75em").style("color", "#6b7280").style("margin-top", "4px").style("max-width", `${innerW + margin.left + margin.right}px`).text(diseases.map((d) => `${diseaseLabel(self, d)} = ${diseaseCfg(self)[d]?.name || d}`).join(" \xB7 "));
-  }
-}
-function renderInsolubleTile(body, td, self, cfg, opts = {}) {
-  const k = opts.scale || 1;
-  const kx = opts.scaleX ?? k;
-  const mr = 4.5 * Math.sqrt(k);
-  const tickFont = k < 1 ? "8.5px" : null;
-  const wholeByCohort = /* @__PURE__ */ new Map();
-  if (cfg.referenceTile) for (const e of entries(td, cfg.referenceTile)) wholeByCohort.set(e.cohortName, e);
-  const insol = entries(td, cfg.key);
-  const rows = orderBy([...new Set(insol.map((e) => e.cohortName))], diseaseOrder(self));
-  const pairs = rows.map((c) => ({
-    cohortName: c,
-    whole: wholeByCohort.get(c) || null,
-    insoluble: insol.find((e) => e.cohortName === c) || null
-  }));
-  const wholeEntry = pairs.find((p) => p.whole)?.whole;
-  const labelOf = (e, fallback) => e ? proteomeLabel(self, e.organism, e.assayName) : fallback;
-  const margin = { top: 24, right: 12, bottom: 34, left: 46 };
-  const innerW = 240 * kx;
-  const innerH = Math.max(90, rows.length * 30 * k);
-  const svg = body.append("svg").attr("width", innerW + margin.left + margin.right).attr("height", innerH + margin.top + margin.bottom);
-  const g = svg.append("g").attr("transform", `translate(${margin.left},${margin.top})`);
-  const values = [];
-  for (const p of pairs) {
-    if (p.whole) values.push(p.whole.log2fc);
-    if (p.insoluble) values.push(p.insoluble.log2fc);
-  }
-  const x = linear().domain(fcDomain(values)).range([0, innerW]);
-  const y = band().domain(rows).range([0, innerH]).padding(0.4);
-  styledAxis(g.append("g").attr("transform", `translate(0,${innerH})`), axisBottom(x).ticks(4), tickFont);
-  styledAxis(g.append("g"), axisLeft(y), tickFont);
-  drawZeroLine(g, x(0), 0, x(0), innerH);
-  svg.append("text").attr("x", margin.left + innerW / 2).attr("y", margin.top + innerH + 30).attr("text-anchor", "middle").style("font-size", "11px").style("fill", "#374151").text("log2FC vs control");
-  const legend = g.append("g").attr("transform", `translate(0,-12)`);
-  for (const [i, item] of [
-    {
-      label: labelOf(wholeEntry, getTileConfig(self, cfg.referenceTile || "")?.title || "reference"),
-      color: WHOLE_COLOR
-    },
-    { label: labelOf(insol[0], cfg.cohortMatch?.assay || cfg.title), color: INSOLUBLE_COLOR }
-  ].entries()) {
-    const lx = i * (kx < 0.6 ? 58 : 80);
-    legend.append("circle").attr("cx", lx).attr("cy", 0).attr("r", 4).attr("fill", item.color).attr("fill-opacity", 0.9);
-    legend.append("text").attr("x", lx + 8).attr("y", 3).style("font-size", "10px").style("fill", "#374151").text(item.label);
-  }
-  for (const p of pairs) {
-    const cy = y(p.cohortName) + y.bandwidth() / 2;
-    if (p.whole && p.insoluble) {
-      g.append("line").attr("x1", x(p.whole.log2fc)).attr("x2", x(p.insoluble.log2fc)).attr("y1", cy).attr("y2", cy).attr("stroke", "#9ca3af").attr("stroke-width", 1.5);
-    }
-    if (p.whole)
-      attachEntryBehavior(
-        drawMarker(g, x(p.whole.log2fc), cy, WHOLE_COLOR, isSig(p.whole), mr),
-        p.whole,
-        self
-      );
-    if (p.insoluble)
-      attachEntryBehavior(
-        drawMarker(g, x(p.insoluble.log2fc), cy, INSOLUBLE_COLOR, isSig(p.insoluble), mr),
-        p.insoluble,
-        self
-      );
-  }
-  addSigFootnote(body);
-}
-var brainGradientSeq = 0;
-function getBrainRegionsData(self) {
-  const gene = self.state?.config?.tw?.term?.name;
-  const [genome, dslabel] = vocabKey(self).split("|");
-  return cachedFetch(`brainRegions|${vocabKey(self)}|${gene}`, async () => {
-    const data = await dofetch3("termdb/brainRegions", { body: { genome, dslabel, gene } });
-    if (data.error) throw data.error;
-    const assets = Object.keys(data.isoforms || {}).length ? await cachedFetch(`brainAssets|${data.svgUrl}`, () => loadBrainAssets(data.svgUrl, Object.keys(data.regions))) : null;
-    return { data, assets };
-  });
-}
-var brainFcScale = (isoformData, disease) => makeBrainFcScale(isoformData.data[disease] || {});
-function drawBrainForDisease(holder, data, assets, isoform, disease, self, brainW, colorScale) {
-  const regionData = data.isoforms[isoform]?.data?.[disease] || {};
-  renderBrainSvg({
-    holder: holder.append("div"),
-    width: brainW,
-    templateUrl: data.templateUrl,
-    assets,
-    regions: data.regions,
-    tip: self.dom.tip,
-    fillByRegion: brainFillByRegion(regionData, colorScale),
-    tooltipByRegion: brainTooltipByRegion(regionData)
-  });
-}
-function drawBrainLegend(holder, colorScale, maxAbsFC, nSig, disease) {
-  const legend = holder.append("div").style("margin-top", "6px");
-  if (!nSig) {
-    legend.append("div").style("font-size", ".75em").style("color", "#6b7280").text(`No region reaches p < ${BRAIN_P_THRESHOLD} for this isoform in ${disease} (all regions grey).`);
-    return;
-  }
-  const w = 160;
-  const h = 10;
-  const svg = legend.append("svg").attr("width", w).attr("height", h + 16);
-  const gradientId = `pv-brain-fc-gradient-${brainGradientSeq++}`;
-  const gradient = svg.append("defs").append("linearGradient").attr("id", gradientId).attr("x1", "0").attr("y1", "0").attr("x2", "1").attr("y2", "0");
-  const steps = 10;
-  for (let i = 0; i <= steps; i++) {
-    const t = i / steps;
-    gradient.append("stop").attr("offset", `${t * 100}%`).attr("stop-color", colorScale(-maxAbsFC + t * 2 * maxAbsFC));
-  }
-  svg.append("rect").attr("width", w).attr("height", h).attr("fill", `url(#${gradientId})`).attr("stroke", "#d1d5db");
-  const labels = [
-    [0, `-${maxAbsFC.toFixed(2)}`, "start"],
-    [w / 2, "0", "middle"],
-    [w, maxAbsFC.toFixed(2), "end"]
-  ];
-  for (const [x, text, anchor] of labels) {
-    svg.append("text").attr("x", x).attr("y", h + 12).attr("text-anchor", anchor).style("font-size", "9px").style("fill", "#374151").text(text);
-  }
-  legend.append("div").style("font-size", ".7em").style("color", "#9ca3af").text(`log\u2082 fold change vs control \xB7 grey: not significant (p \u2265 ${BRAIN_P_THRESHOLD})`);
-}
-function renderBrainRegionTile(body, _td, self, _cfg, opts = {}) {
-  const expanded = !!opts.expanded;
-  const wait = body.append("div").style("font-size", ".75em").style("color", "#9ca3af").text("Loading\u2026");
-  getBrainRegionsData(self).then(({ data, assets }) => {
-    wait.remove();
-    const isoformIds = Object.keys(data.isoforms || {});
-    if (!isoformIds.length || !assets) {
-      body.append("div").style("font-size", ".75em").style("color", "#9ca3af").text("No brain-region data for this protein.");
-      return;
-    }
-    if (!expanded) {
-      const iso = isoformIds[0];
-      const tabsHolder2 = body.append("div");
-      const brainHolder2 = body.append("div");
-      const caption = body.append("div").style("font-size", ".7em").style("color", "#9ca3af").style("margin-top", "2px");
-      const redraw2 = (disease) => {
-        brainHolder2.selectAll("*").remove();
-        const { colorScale, nSig } = brainFcScale(data.isoforms[iso], disease);
-        drawBrainForDisease(brainHolder2, data, assets, iso, disease, self, 185, colorScale);
-        caption.text(
-          nSig ? `red: up \xB7 blue: down \xB7 grey: p \u2265 ${BRAIN_P_THRESHOLD}` : `no region reaches p < ${BRAIN_P_THRESHOLD} in ${disease}`
-        );
-      };
-      if (data.diseases.length > 1) makeDiseaseTabs(tabsHolder2, data.diseases, data.diseases[0], redraw2, ".75em");
-      redraw2(data.diseases[0]);
-      return;
-    }
-    const description = self.app.vocabApi.termdbConfig?.queries?.proteome?.brainRegions?.description;
-    if (description) {
-      body.append("div").style("font-size", ".8em").style("color", "#555").style("max-width", "640px").style("line-height", "1.4").style("margin-bottom", "8px").text(description);
-    }
-    let selectedIso = isoformIds[0];
-    let selectedDisease = data.diseases[0];
-    const controlRow = body.append("div").style("margin-bottom", "8px").style("font-size", ".85em");
-    controlRow.append("span").style("font-weight", "600").text("Isoform: ");
-    const tabsHolder = body.append("div");
-    const brainHolder = body.append("div");
-    const redraw = () => {
-      brainHolder.selectAll("*").remove();
-      const isoformData = data.isoforms[selectedIso];
-      if (!isoformData) return;
-      const { colorScale, maxAbsFC, nSig } = brainFcScale(isoformData, selectedDisease);
-      drawBrainForDisease(brainHolder, data, assets, selectedIso, selectedDisease, self, 460, colorScale);
-      drawBrainLegend(brainHolder, colorScale, maxAbsFC, nSig, selectedDisease);
-    };
-    if (data.diseases.length > 1) {
-      makeDiseaseTabs(
-        tabsHolder,
-        data.diseases,
-        selectedDisease,
-        (d) => {
-          selectedDisease = d;
-          redraw();
-        },
-        ".9em"
-      );
-    }
-    if (isoformIds.length > 1) {
-      const sel = controlRow.append("select").style("margin-left", "5px").on("change", () => {
-        selectedIso = sel.node().value;
-        redraw();
-      });
-      sel.selectAll("option").data(isoformIds).enter().append("option").attr("value", (d) => d).text((d) => `${data.isoforms[d].gene_name} \u2014 ${d}`);
-    } else {
-      controlRow.append("span").style("margin-left", "5px").text(`${data.isoforms[selectedIso].gene_name} \u2014 ${selectedIso}`);
-    }
-    redraw();
-  }).catch((err) => {
-    wait.style("color", "#b91c1c").text(`Failed to load: ${err?.message || err}`);
-    if (self.app?.opts?.debug) console.error(err);
-  });
-}
-function renderMouseModelsTile(body, td, self, cfg, opts = {}) {
-  const k = opts.scale || 1;
-  const kx = opts.scaleX ?? k;
-  const mr = 4 * Math.sqrt(k);
-  const tickFont = k < 1 ? "8.5px" : null;
-  const aged = /* @__PURE__ */ new Map();
-  const singles = [];
-  for (const e of entries(td, cfg.key)) {
-    const age = e.catalog.ageGroup ? parseAge(e.catalog.ageGroup) : null;
-    if (age === null) {
-      singles.push(e);
-      continue;
-    }
-    if (!aged.has(e.catalog.model)) aged.set(e.catalog.model, []);
-    aged.get(e.catalog.model).push({ age, e });
-  }
-  for (const pts of aged.values()) pts.sort((a, b) => a.age - b.age);
-  const ages = [...new Set([...aged.values()].flatMap((pts) => pts.map((p) => p.age)))].sort((a, b) => a - b);
-  const hasAged = ages.length > 0;
-  const margin = { top: 20, right: 12, bottom: 36, left: 46 };
-  const mainW = hasAged ? 210 * kx : 0;
-  const stripGap = singles.length && hasAged ? 18 * kx : 0;
-  const stripW = singles.length * 34 * kx;
-  const innerH = 150 * k;
-  const svg = body.append("svg").attr("width", margin.left + mainW + stripGap + stripW + margin.right).attr("height", innerH + margin.top + margin.bottom);
-  const g = svg.append("g").attr("transform", `translate(${margin.left},${margin.top})`);
-  const values = [];
-  for (const pts of aged.values()) for (const p of pts) values.push(p.e.log2fc);
-  for (const e of singles) values.push(e.log2fc);
-  const x = linear().domain(ages.length > 1 ? [ages[0], ages[ages.length - 1]] : [(ages[0] ?? 0) - 1, (ages[0] ?? 0) + 1]).range([0, mainW]);
-  const y = linear().domain(fcDomain(values)).range([innerH, 0]);
-  if (hasAged) {
-    styledAxis(g.append("g").attr("transform", `translate(0,${innerH})`), axisBottom(x).tickValues(ages), tickFont);
-    svg.append("text").attr("x", margin.left + mainW / 2).attr("y", margin.top + innerH + 32).attr("text-anchor", "middle").style("font-size", "11px").style("fill", "#374151").text(cfg.xLabel || "age");
-  }
-  styledAxis(g.append("g"), axisLeft(y).ticks(4), tickFont);
-  drawZeroLine(g, 0, y(0), mainW + stripGap + stripW, y(0));
-  yAxisTitle(svg, innerH, margin.top, cfg.yLabel || "log2FC vs control");
-  let legendX = 0;
-  for (const model of orderBy([...aged.keys()], modelOrder(self))) {
-    const pts = aged.get(model);
-    const color = modelColor(self, model);
-    const path = line_default().x((p) => x(p.age)).y((p) => y(p.e.log2fc));
-    g.append("path").attr("d", path(pts)).attr("fill", "none").attr("stroke", color).attr("stroke-width", 1.5).attr("stroke-opacity", 0.75);
-    for (const p of pts)
-      attachEntryBehavior(drawMarker(g, x(p.age), y(p.e.log2fc), color, isSig(p.e), mr), p.e, self);
-    g.append("text").attr("x", legendX).attr("y", -8).style("font-size", "10px").style("font-weight", "600").style("fill", color).text(model);
-    legendX += 52;
-  }
-  if (singles.length) {
-    const stripX0 = mainW + stripGap;
-    g.append("line").attr("x1", stripX0 - stripGap / 2).attr("x2", stripX0 - stripGap / 2).attr("y1", 0).attr("y2", innerH).attr("stroke", "#d1d5db").attr("stroke-dasharray", "2 3");
-    for (const [i, e] of singles.entries()) {
-      const cx = stripX0 + i * 34 * kx + 17 * kx;
-      attachEntryBehavior(drawMarker(g, cx, y(e.log2fc), SINGLE_MODEL_COLOR, isSig(e), mr), e, self);
-      const lbl = g.append("text").attr("x", cx).attr("y", innerH + 14).attr("text-anchor", "middle").style("font-size", "9px").style("fill", "#6b7280").text(e.catalog.model);
-      if (kx < 0.6) lbl.attr("transform", `rotate(-38 ${cx} ${innerH + 14})`).attr("text-anchor", "end");
-    }
-  }
-  addSigFootnote(body);
-}
-function renderCellTypesTile(body, td, self, cfg, opts = {}) {
-  const k = opts.scale || 1;
-  const kx = opts.scaleX ?? k;
-  const all = entries(td, cfg.key);
-  const models = orderBy([...new Set(all.map((e) => e.catalog.model))], modelOrder(self));
-  const cellTypes = orderBy([...new Set(all.map((e) => e.catalog.cellType))], Object.keys(cellTypeCfg(self)));
-  const agesByModel = /* @__PURE__ */ new Map();
-  for (const m of models) {
-    const ages = [...new Set(all.filter((e) => e.catalog.model === m).map((e) => e.catalog.ageGroup))].sort(byAge);
-    agesByModel.set(m, ages);
-  }
-  const CELL_W = 34 * kx;
-  const CELL_H = 28 * k;
-  const ROW_LABEL_W = 82;
-  const MODEL_GAP = 12 * kx;
-  const HEADER_H = 34;
-  const colX = /* @__PURE__ */ new Map();
-  let xCursor = 0;
-  const modelSpans = [];
-  for (const m of models) {
-    const x0 = xCursor;
-    for (const a of agesByModel.get(m)) {
-      colX.set(`${m}|${a}`, xCursor + CELL_W / 2);
-      xCursor += CELL_W;
-    }
-    modelSpans.push({ model: m, x0, x1: xCursor });
-    xCursor += MODEL_GAP;
-  }
-  const gridW = xCursor - MODEL_GAP;
-  const gridH = cellTypes.length * CELL_H;
-  const svg = body.append("svg").attr("width", ROW_LABEL_W + gridW + 10).attr("height", HEADER_H + gridH + 8);
-  const g = svg.append("g").attr("transform", `translate(${ROW_LABEL_W},${HEADER_H})`);
-  for (const span of modelSpans) {
-    svg.append("text").attr("x", ROW_LABEL_W + (span.x0 + span.x1) / 2).attr("y", 12).attr("text-anchor", "middle").style("font-size", "10px").style("font-weight", "600").style("fill", modelColor(self, span.model)).text(span.model);
-  }
-  for (const [key, cx] of colX) {
-    svg.append("text").attr("x", ROW_LABEL_W + cx).attr("y", 27).attr("text-anchor", "middle").style("font-size", "9px").style("fill", "#6b7280").text(key.split("|")[1]);
-  }
-  for (const [i, ct] of cellTypes.entries()) {
-    svg.append("text").attr("x", ROW_LABEL_W - 6).attr("y", HEADER_H + i * CELL_H + CELL_H / 2 + 3).attr("text-anchor", "end").style("font-size", "10px").style("fill", "#374151").text(ct);
-  }
-  const maxAbsFc = Math.max(1, ...all.map((e) => Math.abs(e.log2fc)));
-  const colorScale = linear().domain([-maxAbsFc, 0, maxAbsFc]).range([FC_NEG_COLOR, FC_ZERO_COLOR, FC_POS_COLOR]);
-  const NEG_LOG_P_CAP = 10;
-  const rScale = sqrt().domain([0, NEG_LOG_P_CAP]).range([3 * k, Math.min(11 * k, CELL_W / 2 - 0.5)]);
-  for (const e of all) {
-    const cx = colX.get(`${e.catalog.model}|${e.catalog.ageGroup}`);
-    const row = cellTypes.indexOf(e.catalog.cellType);
-    if (cx === void 0 || row < 0) continue;
-    const negLogP = e.fdr === null ? 0 : Math.min(NEG_LOG_P_CAP, -Math.log10(Math.max(e.fdr, 1e-300)));
-    const circle = g.append("circle").attr("cx", cx).attr("cy", row * CELL_H + CELL_H / 2).attr("r", rScale(negLogP)).attr("fill", colorScale(e.log2fc)).attr("stroke", isSig(e) ? "#374151" : "#d1d5db").attr("stroke-width", 1);
-    attachEntryBehavior(circle, e, self);
-  }
-  const foot = body.append("div").style("font-size", ".7em").style("color", "#9ca3af").style("margin-top", "2px");
-  foot.style("max-width", "100%");
-  foot.append("span").text(`color: log2FC (purple down, blue up) \xB7 size: \u2212log10(FDR) \xB7 outline: FDR < ${SIG_P}`);
-  for (const ct of cellTypes) {
-    const note = cellTypeCfg(self)[ct]?.note;
-    if (note) foot.append("div").text(note);
-  }
-}
-function renderPlaqueTile(body, td, self, cfg, opts = {}) {
-  const k = opts.scale || 1;
-  const kx = opts.scaleX ?? k;
-  const mr = 4 * Math.sqrt(k);
-  const tickFont = k < 1 ? "8.5px" : null;
-  const all = entries(td, cfg.key);
-  const series = all.filter((e) => e.catalog.ageGroup && e.catalog.model);
-  const reference = all.filter((e) => !(e.catalog.ageGroup && e.catalog.model));
-  const refLabel = (e) => e.organism.charAt(0).toUpperCase() + e.organism.slice(1);
-  const ages = [...new Set(series.map((e) => e.catalog.ageGroup))].sort(byAge);
-  const refCategories = [...new Set(reference.map(refLabel))];
-  const categories = [...ages, ...refCategories];
-  const margin = { top: 20, right: 14, bottom: 36, left: 46 };
-  const innerW = Math.max(180, categories.length * 52) * kx;
-  const innerH = 140 * k;
-  const svg = body.append("svg").attr("width", innerW + margin.left + margin.right).attr("height", innerH + margin.top + margin.bottom);
-  const g = svg.append("g").attr("transform", `translate(${margin.left},${margin.top})`);
-  const x = point().domain(categories).range([0, innerW]).padding(0.5);
-  const y = linear().domain(fcDomain(all.map((e) => e.log2fc))).range([innerH, 0]);
-  const xAxisG = styledAxis(g.append("g").attr("transform", `translate(0,${innerH})`), axisBottom(x), tickFont);
-  if (kx < 0.6) rotateXTicks(xAxisG);
-  styledAxis(g.append("g"), axisLeft(y).ticks(4), tickFont);
-  drawZeroLine(g, 0, y(0), innerW, y(0));
-  yAxisTitle(svg, innerH, margin.top, cfg.yLabel || "log2FC vs control");
-  if (kx >= 0.6) {
-    svg.append("text").attr("x", margin.left + innerW / 2).attr("y", margin.top + innerH + 32).attr("text-anchor", "middle").style("font-size", "11px").style("fill", "#374151").text(cfg.xLabel || "age");
-  }
-  if (refCategories.length && ages.length) {
-    const xSep = (x(ages[ages.length - 1]) + x(refCategories[0])) / 2;
-    g.append("line").attr("x1", xSep).attr("x2", xSep).attr("y1", 0).attr("y2", innerH).attr("stroke", "#d1d5db").attr("stroke-dasharray", "2 3");
-  }
-  const models = orderBy([...new Set(series.map((e) => e.catalog.model))], modelOrder(self));
-  let legendX = 0;
-  for (const model of models) {
-    const color = modelColor(self, model);
-    const pts = series.filter((e) => e.catalog.model === model).sort((a, b) => byAge(a.catalog.ageGroup, b.catalog.ageGroup));
-    const path = line_default().x((e) => x(e.catalog.ageGroup)).y((e) => y(e.log2fc));
-    g.append("path").attr("d", path(pts)).attr("fill", "none").attr("stroke", color).attr("stroke-width", 1.5).attr("stroke-opacity", 0.75).attr("stroke-dasharray", pts.length < ages.length ? "5 3" : null);
-    for (const e of pts)
-      attachEntryBehavior(drawMarker(g, x(e.catalog.ageGroup), y(e.log2fc), color, isSig(e), mr), e, self);
-    g.append("text").attr("x", legendX).attr("y", -8).style("font-size", "10px").style("font-weight", "600").style("fill", color).text(model);
-    legendX += 52;
-  }
-  for (const e of reference) {
-    const cx = x(refLabel(e));
-    const cy = y(e.log2fc);
-    const r = 5.5 * Math.sqrt(k);
-    const diamond = g.append("path").attr("d", `M ${cx} ${cy - r} L ${cx + r} ${cy} L ${cx} ${cy + r} L ${cx - r} ${cy} Z`).attr("fill", isSig(e) ? REFERENCE_COLOR : "#fff").attr("stroke", REFERENCE_COLOR).attr("stroke-width", 1.5);
-    attachEntryBehavior(diamond, e, self);
-  }
-  addSigFootnote(body);
-}
-function getGeneRanks(self) {
-  const gene = self.state?.config?.tw?.term?.name;
-  const [genome, dslabel] = vocabKey(self).split("|");
-  return cachedFetch(`geneRanks|${vocabKey(self)}|${gene}`, async () => {
-    const data = await dofetch3("termdb/geneRanking", { body: { genome, dslabel, gene } });
-    if (data.error) throw data.error;
-    return data.geneRanks || {};
-  });
-}
-var rankColor = linear().domain([0, 0.1, 1]).range(["#1d4ed8", "#93c5fd", "#f3f4f6"]).clamp(true);
-function renderMultiomicRankTile(body, _td, self, _cfg, opts = {}) {
-  const expanded = !!opts.expanded;
-  const rankCfg = self.app.vocabApi.termdbConfig?.queries?.geneRanking || {};
-  const modalities = rankCfg.modalities || [];
-  const integrativeColumn = rankCfg.integrativeColumn;
-  const statColumns = rankCfg.statColumns || [];
-  const rankingLabel = (key) => rankCfg.labels?.[key] || key;
-  const wait = body.append("div").style("font-size", ".75em").style("color", "#9ca3af").text("Loading\u2026");
-  getGeneRanks(self).then((geneRanks) => {
-    wait.remove();
-    const keys = Object.keys(geneRanks);
-    const ranked = keys.filter((k) => geneRanks[k].row);
-    if (!ranked.length) {
-      body.append("div").style("font-size", ".75em").style("color", "#9ca3af").text("Not present in the multiomic rankings.");
-      return;
-    }
-    const fmt = (n) => n.toLocaleString();
-    if (expanded) {
-      const description = self.app.vocabApi.termdbConfig?.queries?.geneRanking?.description;
-      if (description) {
-        body.append("div").style("font-size", ".8em").style("color", "#555").style("max-width", "640px").style("line-height", "1.4").style("margin-bottom", "10px").text(description);
-      }
-    }
-    for (const key of keys) {
-      const r = geneRanks[key];
-      const colIdx = new Map(r.columns.map((c, i) => [c, i]));
-      const intIdx = integrativeColumn ? colIdx.get(integrativeColumn) : void 0;
-      const intRank = r.row && intIdx !== void 0 ? r.row[intIdx] : null;
-      const section = body.append("div").style("margin-bottom", expanded ? "12px" : "6px");
-      const head = section.append("div").style("display", "flex").style("align-items", "baseline").style("gap", "6px").style("font-size", expanded ? ".9em" : ".8em");
-      head.append("span").style("font-weight", "600").style("color", "#374151").text(rankingLabel(key));
-      if (!r.row) {
-        head.append("span").style("color", "#9ca3af").text("not ranked");
-        continue;
-      }
-      head.append("span").style("color", typeof intRank === "number" ? "#111827" : "#9ca3af").text(typeof intRank === "number" ? `#${fmt(intRank)} of ${fmt(r.counts[intIdx])}` : "no integrative rank");
-      const mods = modalities.filter((m) => colIdx.has(m));
-      if (!expanded) {
-        const strip = section.append("div").style("display", "flex").style("gap", "2px").style("margin-top", "2px");
-        for (const m of mods) {
-          const c = colIdx.get(m);
-          const v = r.row[c];
-          const n = r.counts[c];
-          const pct = typeof v === "number" && n ? (v - 1) / Math.max(1, n - 1) : null;
-          strip.append("div").attr("title", pct === null ? `${m}: not ranked` : `${m}: #${fmt(v)} of ${fmt(n)}`).style("width", "20px").style("height", "9px").style("border-radius", "2px").style("background", pct === null ? "#fff" : rankColor(pct)).style("border", pct === null ? "1px dashed #d1d5db" : "1px solid transparent").style("box-sizing", "border-box");
-        }
-        continue;
-      }
-      const tbl = table2col({ holder: section.append("table") });
-      for (const m of mods) {
-        const c = colIdx.get(m);
-        const v = r.row[c];
-        const n = r.counts[c];
-        const pctTop = typeof v === "number" ? 100 * v / n : null;
-        const pctText = pctTop === null ? "" : ` (top ${pctTop < 0.1 ? pctTop.toFixed(2) : pctTop.toFixed(1)}%)`;
-        tbl.addRow(m, typeof v === "number" ? `#${fmt(v)} of ${fmt(n)}${pctText}` : "not ranked");
-      }
-      for (const extra of statColumns) {
-        const c = colIdx.get(extra);
-        if (c === void 0) continue;
-        const v = r.row[c];
-        tbl.addRow(extra, typeof v === "number" ? v < 1e-3 && v > 0 ? v.toExponential(2) : String(v) : "NA");
-      }
-    }
-    if (!expanded) {
-      const foot = body.append("div").style("font-size", ".7em").style("color", "#9ca3af").style("margin-top", "4px");
-      foot.text("strip: one cell per modality, darker = ranked higher \xB7 hover for ranks");
-    }
-  }).catch((err) => {
-    wait.style("color", "#b91c1c").text(`Failed to load: ${err?.message || err}`);
-    if (self.app?.opts?.debug) console.error(err);
-  });
-}
-function getConcordance(self, x, y) {
-  const [genome, dslabel] = vocabKey(self).split("|");
-  const refKey = (r) => `${r.organism}|${r.assay}|${r.cohort}`;
-  return cachedFetch(`dapConcordance|${vocabKey(self)}|${refKey(x)}|${refKey(y)}`, async () => {
-    const data = await dofetch3("termdb/dapVolcano", {
-      body: {
-        genome,
-        dslabel,
-        organism: x.organism,
-        assay: x.assay,
-        cohort: x.cohort,
-        concordanceWith: { organism: y.organism, assay: y.assay, cohort: y.cohort }
-      }
-    });
-    if (data.error) throw data.error;
-    return data.concordance;
-  });
-}
-function findPairCohort(self, side, age) {
-  const organisms = self.app?.vocabApi?.termdbConfig?.queries?.proteome?.organisms || {};
-  for (const organism in organisms) {
-    const assays = organisms[organism]?.assays || {};
-    for (const assay in assays) {
-      for (const cohort in assays[assay].cohorts || {}) {
-        const c = assays[assay].cohorts[cohort];
-        if (!c.DAPfile || !c.catalog) continue;
-        if (!cohortMatches(side, organism, assay, c.catalog)) continue;
-        if (side.ageVaries && c.catalog.ageGroup !== age) continue;
-        const label = side.ageVaries ? `${side.label} ${age}` : side.label;
-        return { organism, assay, cohort, label };
-      }
-    }
-  }
-  return null;
-}
-function concordanceAges(self, cfg) {
-  const organisms = self.app?.vocabApi?.termdbConfig?.queries?.proteome?.organisms || {};
-  const sides = (cfg.pairs || []).flatMap((p) => [p.x, p.y]).filter((sd) => sd.ageVaries);
-  const ages = /* @__PURE__ */ new Set();
-  for (const organism in organisms) {
-    const assays = organisms[organism]?.assays || {};
-    for (const assay in assays) {
-      for (const cohort in assays[assay].cohorts || {}) {
-        const c = assays[assay].cohorts[cohort];
-        if (!c.DAPfile || !c.catalog?.ageGroup) continue;
-        if (sides.some((sd) => cohortMatches(sd, organism, assay, c.catalog))) ages.add(c.catalog.ageGroup);
-      }
-    }
-  }
-  return [...ages].sort(byAge);
-}
-function defaultConcordanceAge(self, cfg) {
-  const ages = concordanceAges(self, cfg);
-  if (cfg.defaultAge && ages.includes(cfg.defaultAge)) return cfg.defaultAge;
-  return ages[0] || cfg.defaultAge || "";
-}
-function concordancePairs(self, cfg, age = defaultConcordanceAge(self, cfg)) {
-  const pairs = [];
-  for (const p of cfg.pairs || []) {
-    const x = findPairCohort(self, p.x, age);
-    const y = findPairCohort(self, p.y, age);
-    if (x && y) pairs.push({ key: p.key, label: p.label, x, y });
-  }
-  return pairs;
-}
-async function drawConcordance(holder, self, pair, gene, expanded) {
-  const { points: pts, r: R, p: P } = await getConcordance(self, pair.x, pair.y);
-  const target = gene.toUpperCase();
-  const hit = pts.find((p) => p.gene === target);
-  const margin = expanded ? { top: 14, right: 16, bottom: 44, left: 52 } : { top: 8, right: 10, bottom: 32, left: 38 };
-  const innerW = expanded ? 380 : 150;
-  const innerH = expanded ? 320 : 118;
-  const svg = holder.append("svg").attr("width", innerW + margin.left + margin.right).attr("height", innerH + margin.top + margin.bottom);
-  const g = svg.append("g").attr("transform", `translate(${margin.left},${margin.top})`);
-  const x = linear().domain(fcDomain(pts.map((p) => p.x))).range([0, innerW]);
-  const y = linear().domain(fcDomain(pts.map((p) => p.y))).range([innerH, 0]);
-  const tickFont = expanded ? null : "8.5px";
-  styledAxis(g.append("g").attr("transform", `translate(0,${innerH})`), axisBottom(x).ticks(expanded ? 6 : 4), tickFont);
-  styledAxis(g.append("g"), axisLeft(y).ticks(expanded ? 6 : 4), tickFont);
-  drawZeroLine(g, x(0), 0, x(0), innerH);
-  drawZeroLine(g, 0, y(0), innerW, y(0));
-  yAxisTitle(svg, innerH, margin.top, `${pair.y.label} log2FC`);
-  svg.append("text").attr("x", margin.left + innerW / 2).attr("y", margin.top + innerH + (expanded ? 36 : 28)).attr("text-anchor", "middle").style("font-size", expanded ? "11px" : "10px").style("fill", "#374151").text(`${pair.x.label} log2FC`);
-  for (const p of pts) {
-    if (p === hit) continue;
-    g.append("circle").attr("cx", x(p.x)).attr("cy", y(p.y)).attr("r", expanded ? 1.6 : 1.1).attr("fill", "#9ca3af").attr("fill-opacity", 0.45);
-  }
-  if (hit) {
-    g.append("circle").attr("cx", x(hit.x)).attr("cy", y(hit.y)).attr("r", expanded ? 6 : 4).attr("fill", "#e75480").attr("stroke", "#7f1d1d").attr("stroke-width", 1.2);
-    g.append("text").attr("x", x(hit.x) + (expanded ? 9 : 6)).attr("y", y(hit.y) - (expanded ? 6 : 4)).style("font-size", expanded ? "12px" : "9px").style("font-weight", "600").style("fill", "#7f1d1d").text(gene);
-  }
-  g.append("text").attr("x", innerW).attr("y", -2).attr("text-anchor", "end").style("font-size", expanded ? "11px" : "9px").style("fill", "#374151").attr("title", P === null ? null : `Pearson cor.test p = ${P < 1e-4 ? P.toExponential(1) : P.toFixed(4)}`).text(`R = ${R === null ? "NA" : R.toFixed(2)} \xB7 n = ${pts.length.toLocaleString()}`);
-  if (!hit) {
-    holder.append("div").style("font-size", ".72em").style("color", "#9ca3af").text(`${gene} is not quantified in both datasets`);
-  } else if (expanded) {
-    holder.append("div").style("font-size", ".8em").style("color", "#374151").style("margin-top", "4px").text(`${gene}: ${pair.x.label} log2FC ${hit.x.toFixed(2)} \xB7 ${pair.y.label} log2FC ${hit.y.toFixed(2)}`);
-  }
-}
-function renderConcordanceTile(body, _td, self, cfg, opts = {}) {
-  const expanded = !!opts.expanded;
-  const gene = self.state?.config?.tw?.term?.name || "";
-  let age = defaultConcordanceAge(self, cfg);
-  let pairs = concordancePairs(self, cfg, age);
-  if (!pairs.length) return;
-  let pair = pairs[0];
-  const controls = body.append("div").style("display", "flex").style("align-items", "center").style("gap", "12px");
-  const tabsHolder = controls.append("div");
-  const plotHolder = body.append("div");
-  let generation = 0;
-  const redraw = () => {
-    const gen = ++generation;
-    plotHolder.selectAll("*").remove();
-    const wait = plotHolder.append("div").style("font-size", ".75em").style("color", "#9ca3af").text("Loading\u2026");
-    const target = plotHolder.append("div");
-    drawConcordance(target, self, pair, gene, expanded).then(() => {
-      if (gen !== generation) target.remove();
-      else wait.remove();
-    }).catch((err) => {
-      if (gen !== generation) return;
-      wait.style("color", "#b91c1c").text(`Failed to load: ${err?.message || err}`);
-      if (self.app?.opts?.debug) console.error(err);
-    });
-  };
-  const makeTabs = () => {
-    tabsHolder.selectAll("*").remove();
-    if (pairs.length < 2) return;
-    makeDiseaseTabs(
-      tabsHolder,
-      pairs.map((p) => p.label),
-      pair.label,
-      (label) => {
-        pair = pairs.find((p) => p.label === label) || pairs[0];
-        redraw();
-      },
-      ".9em"
-    );
-  };
-  if (expanded) {
-    makeTabs();
-    const ages = concordanceAges(self, cfg);
-    if (ages.length > 1) {
-      const ageDiv = controls.append("div").style("font-size", ".85em").style("color", "#374151");
-      ageDiv.append("span").text("Age: ");
-      const sel = ageDiv.append("select").style("font-size", "inherit");
-      for (const a of ages)
-        sel.append("option").attr("value", a).property("selected", a === age).text(a);
-      sel.on("change", () => {
-        age = sel.property("value");
-        const next = concordancePairs(self, cfg, age);
-        if (!next.length) {
-          plotHolder.selectAll("*").remove();
-          plotHolder.append("div").style("font-size", ".8em").style("color", "#9ca3af").text(`No cohorts at ${age}`);
-          tabsHolder.selectAll("*").remove();
-          return;
-        }
-        pairs = next;
-        pair = pairs.find((p) => p.key === pair.key) || pairs[0];
-        makeTabs();
-        redraw();
-      });
-    }
-  }
-  redraw();
-  if (!expanded) {
-    body.append("div").style("font-size", ".7em").style("color", "#9ca3af").style("margin-top", "2px").text(`${pair.label}${age ? ", " + age : ""}, all genes \xB7 expand for other pairs and ages`);
-  } else if (cfg.note) {
-    body.append("div").style("font-size", ".75em").style("color", "#9ca3af").style("margin-top", "6px").text(cfg.note);
-  }
-}
-var TILE_RENDERERS = {
-  crossDisease: {
-    has: (td, _s, cfg) => new Set(entries(td, cfg.key).map((e) => e.disease || e.cohortName)).size >= 2,
-    render: renderCrossDiseaseTile
-  },
-  insoluble: { has: (td, _s, cfg) => entries(td, cfg.key).length >= 1, render: renderInsolubleTile },
-  brainRegions: { has: (td, _s, cfg) => entries(td, cfg.key).length >= 2, render: renderBrainRegionTile },
-  mouseModels: { has: (td, _s, cfg) => entries(td, cfg.key).length >= 2, render: renderMouseModelsTile },
-  cellTypes: { has: (td, _s, cfg) => entries(td, cfg.key).length >= 2, render: renderCellTypesTile },
-  plaque: { has: (td, _s, cfg) => entries(td, cfg.key).length >= 1, render: renderPlaqueTile },
-  multiomicRank: {
-    // available whenever the dataset ships rankings; the gene may still be absent
-    has: (_td, self) => !!self?.app?.vocabApi?.termdbConfig?.queries?.geneRanking?.rankings,
-    render: renderMultiomicRankTile
-  },
-  concordance: { has: (_td, self, cfg) => concordancePairs(self, cfg).length > 0, render: renderConcordanceTile }
-  // 'ptm' is rendered by renderPTMSummaryCard from site-level data, not here
-};
-function configuredTiles(self) {
-  const out = [];
-  for (const cfg of getTileConfigs(self)) {
-    const r = TILE_RENDERERS[cfg.key];
-    if (!r) continue;
-    out.push({ ...cfg, ...r });
-  }
-  return out;
-}
-function renderTileError(holder, err, self) {
-  holder.append("div").style("color", "#b91c1c").style("font-size", ".8em").text(`Failed to render: ${err?.message || err}`);
-  if (self?.app?.opts?.debug) console.error(err);
-}
-function renderExpandedTile(holder, tile, td, self) {
-  try {
-    tile.render(holder.append("div"), td, self, tile, { scale: EXPANDED_SCALE, expanded: true });
-  } catch (err) {
-    renderTileError(holder, err, self);
-  }
-}
-function renderStudyTiles(grid, td, self) {
-  const missing = [];
-  for (const tile of configuredTiles(self)) {
-    if (!tile.has(td, self, tile)) {
-      missing.push(tile);
-      continue;
-    }
-    const body = makeTileCard(grid, {
-      title: tile.title,
-      subtitle: tile.subtitle,
-      uniform: true,
-      expand: { render: (holder) => renderExpandedTile(holder, tile, td, self), ...tileExpandState(self, tile.key) }
-    });
-    try {
-      tile.render(body, td, self, tile, { scale: TILE_FACE_SCALE, scaleX: TILE_FACE_SCALE_X });
-    } catch (err) {
-      renderTileError(body, err, self);
-    }
-  }
-  return { missing };
-}
-function renderPlaceholderTiles(grid, tiles) {
-  for (const tile of tiles) {
-    const body = makeTileCard(grid, { title: tile.title, disabled: true, uniform: true });
-    body.style("flex", "1").style("display", "flex").style("align-items", "center").style("justify-content", "center").append("div").style("font-size", ".75em").style("color", "#9ca3af").style("max-width", "200px").style("text-align", "center").text(tile.note || "No data for this protein in this study");
-  }
-}
-var PTM_FALLBACK_PALETTE = ["#d7301f", "#2166ac", "#1b9e77", "#7570b3", "#e6ab02"];
-function firstModSitePos(modSites) {
-  const m = /[A-Za-z](\d+)/.exec(modSites || "");
-  if (!m) return null;
-  const pos = Number(m[1]);
-  return Number.isInteger(pos) && pos >= 1 ? pos : null;
-}
-function renderOverviewVolcanoCard(grid, data, self, opts) {
-  const pts = [];
-  for (const e of data?.cohorts || []) {
-    if (e.PTMType) continue;
-    const log2fc = getLog2Ratio(e.foldChange);
-    const p = Number(e.fdr);
-    if (log2fc === null || !Number.isFinite(p) || p <= 0) continue;
-    pts.push({ x: log2fc, y: -Math.log10(Math.max(p, 1e-300)), sig: p < SIG_P });
-  }
-  const body = makeTileCard(grid, {
-    title: "All sample sets",
-    subtitle: "log2FC vs significance, every cohort",
-    uniform: true,
-    expand: { render: opts.onExpandRender, ...tileExpandState(self, "volcano") }
-  });
-  if (!pts.length) {
-    body.append("div").style("font-size", ".75em").style("color", "#9ca3af").text("No protein-level data.");
-    return;
-  }
-  const margin = { top: 8, right: 10, bottom: 32, left: 38 };
-  const innerW = 156;
-  const innerH = 118;
-  const svg = body.append("svg").attr("width", innerW + margin.left + margin.right).attr("height", innerH + margin.top + margin.bottom);
-  const g = svg.append("g").attr("transform", `translate(${margin.left},${margin.top})`);
-  const x = linear().domain(fcDomain(pts.map((p) => p.x))).range([0, innerW]);
-  const y = linear().domain([0, Math.max(2, ...pts.map((p) => p.y)) * 1.05]).range([innerH, 0]);
-  styledAxis(g.append("g").attr("transform", `translate(0,${innerH})`), axisBottom(x).ticks(4), "8.5px");
-  styledAxis(g.append("g"), axisLeft(y).ticks(4), "8.5px");
-  drawZeroLine(g, x(0), 0, x(0), innerH);
-  g.append("line").attr("x1", 0).attr("x2", innerW).attr("y1", y(-Math.log10(SIG_P))).attr("y2", y(-Math.log10(SIG_P))).attr("stroke", "#9ca3af").attr("stroke-dasharray", "3 3").attr("stroke-opacity", 0.5);
-  yAxisTitle(svg, innerH, margin.top, "\u2212log\u2081\u2080(FDR)");
-  svg.append("text").attr("x", margin.left + innerW / 2).attr("y", margin.top + innerH + 28).attr("text-anchor", "middle").style("font-size", "10px").style("fill", "#374151").text("log2FC");
-  for (const p of pts) {
-    g.append("circle").attr("cx", x(p.x)).attr("cy", y(p.y)).attr("r", 2).attr("fill", p.sig ? "#e75480" : "#c7cbd1").attr("fill-opacity", 0.6);
-  }
-  body.append("div").style("font-size", ".7em").style("color", "#9ca3af").style("margin-top", "2px").text(`${pts.length} dots (accession \xD7 sample set) \xB7 expand for the interactive view`);
-}
-function renderPTMSummaryCard(grid, ptmEntries, self, opts) {
-  if (!ptmEntries?.length) return;
-  const cfg = getTileConfig(self, "ptm");
-  const title = cfg?.title || "PTM sites";
-  const body = makeTileCard(grid, {
-    title,
-    subtitle: cfg?.subtitle || "Site-level log2FC along the protein",
-    uniform: true,
-    expand: { render: opts.onExpandRender, ...tileExpandState(self, "ptm") }
-  });
-  const byOrganism = /* @__PURE__ */ new Map();
-  const typeCounts = /* @__PURE__ */ new Map();
-  for (const e of ptmEntries) {
-    const pos = firstModSitePos(e.modSites);
-    const log2fc = getLog2Ratio(e.foldChange);
-    const mclass = Object.values(e.mclassOverride || {})[0];
-    const existing = typeCounts.get(e.PTMType);
-    const color = existing?.color || mclass?.color || PTM_FALLBACK_PALETTE[typeCounts.size % PTM_FALLBACK_PALETTE.length];
-    const tc = existing || { count: 0, color };
-    tc.count++;
-    typeCounts.set(e.PTMType, tc);
-    if (pos === null || log2fc === null) continue;
-    const p = Number(e.fdr);
-    const entry = {
-      organism: e.organism,
-      assayName: e.assayName,
-      cohortName: e.cohortName,
-      disease: e.disease,
-      uniqueIdentifier: e.uniqueIdentifier,
-      proteinAccession: e.proteinAccession,
-      log2fc,
-      fdr: Number.isFinite(p) && p > 0 ? p : null,
-      testedN: Number(e.testedN) || 0,
-      controlN: Number(e.controlN) || 0,
-      isoformCount: 1,
-      catalog: catalogForEntry(self, e) || {},
-      ptmType: e.PTMType,
-      modSites: e.modSites
-    };
-    const arr = byOrganism.get(e.organism) || [];
-    arr.push({ pos, log2fc, color, entry });
-    byOrganism.set(e.organism, arr);
-  }
-  const stripW = 152;
-  const stripH = 46;
-  const labelW = 46;
-  for (const [organism, points] of byOrganism) {
-    const maxPos = Math.max(...points.map((p) => p.pos)) * 1.05;
-    const maxAbs = Math.max(0.2, ...points.map((p) => Math.abs(p.log2fc)));
-    const row = body.append("div").style("display", "flex").style("align-items", "center").style("gap", "4px");
-    row.append("span").style("flex", `0 0 ${labelW}px`).style("font-size", ".7em").style("color", "#6b7280").text(organism);
-    const svg = row.append("svg").attr("width", stripW).attr("height", stripH);
-    const x = linear().domain([0, maxPos]).range([4, stripW - 4]);
-    const y = linear().domain([-maxAbs, maxAbs]).range([stripH - 4, 4]);
-    svg.append("line").attr("x1", 0).attr("x2", stripW).attr("y1", y(0)).attr("y2", y(0)).attr("stroke", "#e5e7eb");
-    for (const p of points) {
-      svg.append("line").attr("x1", x(p.pos)).attr("x2", x(p.pos)).attr("y1", y(0)).attr("y2", y(p.log2fc)).attr("stroke", p.color).attr("stroke-opacity", 0.4);
-      attachEntryBehavior(
-        svg.append("circle").attr("cx", x(p.pos)).attr("cy", y(p.log2fc)).attr("r", 2.5).attr("fill", p.color).attr("fill-opacity", 0.8),
-        p.entry,
-        self
-      );
-    }
-  }
-  const foot = body.append("div").style("display", "flex").style("gap", "10px").style("flex-wrap", "wrap").style("font-size", ".7em").style("color", "#6b7280").style("margin-top", "4px");
-  for (const [type, tc] of typeCounts) {
-    const item = foot.append("span").style("display", "inline-flex").style("align-items", "center").style("gap", "4px");
-    item.append("span").style("display", "inline-block").style("width", "7px").style("height", "7px").style("border-radius", "50%").style("background", tc.color);
-    item.append("span").text(`${tc.count} ${type}`);
-  }
-}
-function renderCoverageLine(holder, td) {
-  const parts = [`${td.cohortCount} sample set${td.cohortCount === 1 ? "" : "s"}`];
-  if (td.ptmSiteCount) parts.push(`${td.ptmSiteCount} PTM site measurement${td.ptmSiteCount === 1 ? "" : "s"}`);
-  if (td.isoformCount > 1) parts.push(`${td.isoformCount} isoforms (tiles show the most significant per sample set)`);
-  holder.append("div").style("font-size", ".8em").style("color", "#6b7280").style("margin-bottom", "4px").text(parts.join(" \xB7 "));
-}
-
-export {
-  getTileConfig,
-  orderBy,
-  getLog2Ratio,
-  launchViolinPlot,
-  prepareTileData,
-  makeTileGrid,
-  tileExpandState,
-  makeTileCard,
-  renderTileError,
-  renderStudyTiles,
-  renderPlaceholderTiles,
-  renderOverviewVolcanoCard,
-  renderPTMSummaryCard,
-  renderCoverageLine
-};
-//# sourceMappingURL=chunk-MU7GTJYA.js.map