@sjcrh/proteinpaint-client 2.221.0 → 2.223.0

package/dist/mds.survivalplot-JV2JSH74.js

@@ -0,0 +1,472 @@
+import {
+  axisstyle,
+  sayerror,
+  to_svg
+} from "./chunk-JP4IU7DO.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-IRAB3OI7.js";
+import {
+  Menu
+} from "./chunk-CNFTQSNE.js";
+import "./chunk-RIHO7ZD5.js";
+import "./chunk-TVJOSRCH.js";
+import "./chunk-3CIL7KH7.js";
+import "./chunk-T4XPCSLP.js";
+import {
+  dofetch
+} from "./chunk-4TJO2DGU.js";
+import "./chunk-W5J3LTYS.js";
+import "./chunk-MHWYRNGA.js";
+import "./chunk-JHLF2ZC2.js";
+import {
+  axisBottom,
+  axisLeft,
+  bplen,
+  category10_default
+} from "./chunk-WJLRU5OF.js";
+import "./chunk-HBNB5TRH.js";
+import "./chunk-PF4DSFDR.js";
+import {
+  linear,
+  ordinal
+} from "./chunk-4OLM3KSB.js";
+import "./chunk-PWYMHUXY.js";
+import "./chunk-TLT4YIG3.js";
+import "./chunk-5R63Q5KH.js";
+import {
+  select_default
+} from "./chunk-I6Y4O3RR.js";
+import "./chunk-Q5RDQNIT.js";
+import "./chunk-HS5PO5ZQ.js";
+
+// src/mds.survivalplot.js
+async function init(obj, holder, debugmode) {
+  if (debugmode) {
+    window.obj = obj;
+  }
+  obj.plots = [];
+  obj.menu = new Menu({ padding: "5px" });
+  obj.tip = new Menu({ padding: "5px" });
+  obj.errordiv = holder.append("div").style("margin", "10px");
+  obj.sayerror = (e) => {
+    sayerror(obj.errordiv, typeof e == "string" ? e : e.message);
+    if (e.stack) console.log(e.stack);
+  };
+  obj.uidiv = holder.append("div").style("margin", "20px");
+  obj.plotdiv = holder.append("div").style("margin", "20px");
+  obj.legendtable = holder.append("table").style("border-spacing", "5px");
+  holder.append("button").text("SVG").on("click", () => {
+    to_svg(obj.plotlist[0].svg.node(), "Survival");
+  });
+  try {
+    await init_dataset_config(obj);
+    if (!obj.plotlist) {
+      obj.plotlist = [];
+    }
+    if (!Array.isArray(obj.plotlist)) throw ".plotlist should be array";
+    if (obj.plotlist.length == 0) {
+      const p = {
+        type: obj.plottypes[0].key
+      };
+      obj.plotlist.push(p);
+    }
+    for (const p of obj.plotlist) {
+      init_a_plot(p, obj);
+    }
+  } catch (e) {
+    if (e.stack) console.log(e.stack);
+    obj.sayerror("Cannot make plot: " + (e.message || e));
+  }
+}
+function init_dataset_config(obj) {
+  const par = {
+    genome: obj.genome.name,
+    dslabel: obj.mds.label,
+    init: 1
+  };
+  return dofetch("mdssurvivalplot", par).then((data) => {
+    if (data.error) throw data.error;
+    if (!data.plottypes) throw "plottypes[] missing";
+    obj.plottypes = data.plottypes;
+    obj.samplegroupings = data.samplegroupings;
+  });
+}
+function init_a_plot(p, obj) {
+  init_a_plot_filldefault(p, obj);
+  const div = obj.uidiv.append("div").style("margin", "20px");
+  if (obj.plottypes.length > 1) {
+    const s = div.append("div").style("margin-bottom", "10px").append("select").on("change", (event) => {
+      p.type = event.target.options[event.target.selectedIndex].value;
+    });
+    for (const [i, t] of obj.plottypes.entries()) {
+      s.append("option").text(t.name).property("value", t.key);
+      if (t.key == p.type) {
+        s.node().selectedIndex = i;
+      }
+    }
+  }
+  if (obj.samplegroupings && !p.samplerule.full.immutable) {
+    const row = div.append("div").style("margin-bottom", "20px");
+    const custom_input_row = div.append("div").style("display", "none");
+    row.append("span").html("Choose samples from ").style("opacity", 0.5);
+    const attr2select = {};
+    const s = row.append("select").style("margin-right", "5px").on("change", (event) => {
+      for (const k in attr2select) {
+        attr2select[k].style("display", "none");
+      }
+      const o = event.target.options[event.target.selectedIndex];
+      custom_input_row.style("display", o.usesampleset ? "block" : "none");
+      if (o.useall) {
+        p.samplerule.full.useall = 1;
+        delete p.samplerule.full.byattr;
+        return;
+      }
+      if (o.usesampleset) {
+        delete p.samplerule.full.byattr;
+        delete p.samplerule.full.useall;
+        p.samplerule.full.usesampleset = 1;
+        show_sampleinput(p, custom_input_row);
+        return;
+      }
+      delete p.samplerule.full.useall;
+      p.samplerule.full.byattr = 1;
+      p.samplerule.key = o.key;
+      const s3 = attr2select[o.key];
+      s3.style("display", "inline");
+      p.samplerule.full.value = s3.node().options[s3.node().selectedIndex].value;
+    });
+    for (const [i, attr] of obj.samplegroupings.entries()) {
+      s.append("option").text(attr.label).property("key", attr.key);
+      const usingthisattr = p.samplerule.full.byattr && p.samplerule.full.key == attr.key;
+      if (usingthisattr) {
+        s.node().selectedIndex = i;
+      }
+      const s2 = row.append("select").on("change", (event) => {
+        p.samplerule.full.value = event.target.options[event.target.selectedIndex].value;
+      });
+      attr2select[attr.key] = s2;
+      s2.style("display", usingthisattr ? "inline" : "none");
+      for (const [j, v] of attr.values.entries()) {
+        s2.append("option").text(v.value + " (n=" + v.count + ")").property("value", v.value);
+        if (usingthisattr && v.value == p.samplerule.full.value) {
+          s2.node().selectedIndex = j;
+        }
+      }
+    }
+    s.append("option").text("all samples").property("useall", 1);
+    if (p.samplerule.full.useall) {
+      s.node().selectedIndex = obj.samplegroupings.length;
+    }
+    s.append("option").text("custom sampleset").property("usesampleset", 1);
+  }
+  show_dividerules(p, div);
+  p.button = div.append("button").text("Make plot").on("click", () => {
+    loadPlot(p, obj);
+  });
+  p.d = obj.plotdiv.append("div").style("margin", "20px"), p.legend = {
+    d_pvalue: p.d.append("div").style("margin", "10px"),
+    d_samplefull: p.d.append("div").style("margin", "10px"),
+    d_curves: p.d.append("div").style("margin", "10px")
+  };
+  p.svg = p.d.append("svg");
+  p.resize_handle = p.d.append("div").append("div").attr("class", "sja_clbtext").text("drag to resize").style("float", "right");
+  if (p.renderplot) {
+    loadPlot(p, obj);
+  }
+}
+function init_a_plot_filldefault(p, obj) {
+  if (!p.type) {
+    p.type = obj.plottypes[0].key;
+  }
+  if (!p.samplerule) {
+    p.samplerule = {};
+  }
+  if (!p.samplerule.full) {
+    p.samplerule.full = {};
+  }
+  if (obj.samplegroupings) {
+    if (!p.samplerule.full.useall) {
+      p.samplerule.full.byattr = 1;
+      if (!p.samplerule.full.key) {
+        p.samplerule.full.key = obj.samplegroupings[0].key;
+        p.samplerule.full.value = obj.samplegroupings[0].values[0].value;
+      }
+    }
+  } else {
+    p.samplerule.full.useall = 1;
+  }
+  if (p.samplerule.set) {
+    const st = p.samplerule.set;
+    if (st.geneexpression) {
+      if (!st.bymedian && !st.byquartile) {
+        st.bymedian = 1;
+      }
+    }
+  }
+  if (!p.width) p.width = 500;
+  if (!p.height) p.height = 500;
+  if (!p.toppad) p.toppad = 10;
+  if (!p.rightpad) p.rightpad = 10;
+  if (!p.xaxispad) p.xaxispad = 10;
+  if (!p.yaxispad) p.yaxispad = 10;
+  if (!p.xaxish) p.xaxish = 40;
+  if (!p.yaxisw) p.yaxisw = 65;
+  if (!p.censorticksize) p.censorticksize = 6;
+  if (!p.tickfontsize) p.tickfontsize = 14;
+  if (!p.labfontsize) p.labfontsize = 15;
+}
+function doPlot(plot, obj) {
+  const colorfunc = ordinal(category10_default);
+  const minx = 0;
+  let maxx = 0;
+  for (const curve of plot.samplesets) {
+    curve.color = colorfunc(curve.name);
+    for (const s of curve.steps) {
+      maxx = Math.max(maxx, s.x);
+    }
+  }
+  plot.svg.selectAll("*").remove();
+  const curves_g = plot.svg.append("g");
+  for (const curve of plot.samplesets) {
+    curve.path = curves_g.append("path").attr("stroke", curve.color).attr("fill", "none");
+    curve.ticks = curves_g.append("path").attr("stroke", curve.color).attr("fill", "none");
+  }
+  const yaxis_g = plot.svg.append("g");
+  const yaxis_scale = linear().domain([0, 1]);
+  const yaxis_lab_g = plot.svg.append("g");
+  const yaxis_lab = yaxis_lab_g.append("text").text("Survival").attr("transform", "rotate(-90)");
+  const xaxis_g = plot.svg.append("g");
+  const xaxis_scale = linear().domain([minx, maxx]);
+  const xaxis_lab = plot.svg.append("text").attr("font-size", plot.labfontsize).text(obj.plottypes.find((i) => i.key == plot.type).timelabel).attr("x", plot.yaxisw + plot.yaxispad + plot.width / 2).attr("y", plot.toppad + plot.height + plot.xaxispad + plot.xaxish - 3);
+  function resize() {
+    curves_g.attr("transform", "translate(" + (plot.yaxisw + plot.yaxispad) + "," + plot.toppad + ")");
+    for (const curve of plot.samplesets) {
+      const ticks = [];
+      const pathd = ["M 0 0"];
+      for (const s of curve.steps) {
+        pathd.push("H " + plot.width * s.x / maxx);
+        const y = plot.height * (s.y + s.drop);
+        pathd.push("V " + y);
+        if (s.censored) {
+          const y2 = plot.height * s.y;
+          for (const c of s.censored) {
+            const x = plot.width * c / maxx;
+            ticks.push(
+              "M " + (x - plot.censorticksize / 2) + " " + (y2 - plot.censorticksize / 2) + " l " + plot.censorticksize + " " + plot.censorticksize + " M " + (x + plot.censorticksize / 2) + " " + (y2 - plot.censorticksize / 2) + " l -" + plot.censorticksize + " " + plot.censorticksize
+            );
+          }
+        }
+      }
+      curve.path.attr("d", pathd.join(" "));
+      if (ticks.length) {
+        curve.ticks.attr("d", ticks.join(" "));
+      }
+    }
+    yaxis_g.attr("transform", "translate(" + plot.yaxisw + "," + plot.toppad + ")");
+    axisstyle({
+      axis: yaxis_g.call(
+        axisLeft().scale(yaxis_scale.range([plot.height, 0])).ticks(Math.floor(plot.height / (plot.tickfontsize + 20)))
+      ),
+      showline: 1,
+      fontsize: plot.tickfontsize
+    });
+    yaxis_lab_g.attr("transform", "translate(" + plot.labfontsize + "," + (plot.toppad + plot.height / 2) + ")");
+    yaxis_lab.attr("font-size", plot.labfontsize);
+    xaxis_g.attr(
+      "transform",
+      "translate(" + (plot.yaxisw + plot.yaxispad) + "," + (plot.toppad + plot.height + plot.xaxispad) + ")"
+    );
+    let xticknumber;
+    xaxis_g.append("text").text(maxx).attr("font-size", plot.tickfontsize).each(function() {
+      xticknumber = Math.floor(plot.width / (this.getBBox().width + 30));
+    }).remove();
+    axisstyle({
+      axis: xaxis_g.call(
+        axisBottom().scale(xaxis_scale.range([0, plot.width])).ticks(xticknumber)
+      ),
+      showline: 1,
+      fontsize: plot.tickfontsize
+    });
+    xaxis_lab.attr("font-size", plot.labfontsize).attr("x", plot.yaxisw + plot.yaxispad + plot.width / 2).attr("y", plot.toppad + plot.height + plot.xaxispad + plot.xaxish - 3);
+    plot.svg.attr("width", plot.yaxisw + plot.yaxispad + plot.width + plot.rightpad).attr("height", plot.toppad + plot.height + plot.xaxispad + plot.xaxish);
+  }
+  resize();
+  plot.resize_handle.on("mousedown", (event) => {
+    event.preventDefault();
+    const b = select_default(document.body);
+    const x = event.clientX;
+    const y = event.clientY;
+    const w0 = plot.width;
+    const h0 = plot.height;
+    b.on("mousemove", () => {
+      plot.width = w0 + event.clientX - x;
+      plot.height = h0 + event.clientY - y;
+      resize();
+    });
+    b.on("mouseup", () => {
+      b.on("mousemove", null).on("mouseup", null);
+    });
+  });
+  if (Number.isFinite(plot.pvalue)) {
+    plot.legend.d_pvalue.style("display", "block").text("P-value: " + plot.pvalue);
+  } else {
+    plot.legend.d_pvalue.style("display", "none");
+  }
+  plot.legend.d_curves.selectAll("*").remove();
+  for (const c of plot.samplesets) {
+    plot.legend.d_curves.append("div").style("margin", "3px").html(
+      '<span style="background:' + c.color + '">&nbsp;&nbsp;</span> ' + c.name + (c.pvalue == void 0 ? "" : ", P-value: " + c.pvalue)
+    );
+  }
+}
+function loadPlot(plot, obj) {
+  plot.button.text("Loading...").attr("disabled", 1);
+  const par = {
+    genome: obj.genome.name,
+    dslabel: obj.mds.label,
+    type: plot.type,
+    samplerule: plot.samplerule
+  };
+  dofetch("mdssurvivalplot", par).then((data) => {
+    if (data.error) throw data.error;
+    if (!data.samplesets) throw "samplesets[] missing";
+    plot.samplesets = data.samplesets;
+    plot.pvalue = data.pvalue;
+    doPlot(plot, obj);
+    if (plot.samplerule.set && plot.samplerule.set.mutation) {
+      if (plot.mutation_count.cnv) plot.mutation_count.cnv.html("(n=" + data.count_cnv + ")&nbsp;");
+      if (plot.mutation_count.loh) plot.mutation_count.loh.html("(n=" + data.count_loh + ")&nbsp;");
+      if (plot.mutation_count.snvindel) plot.mutation_count.snvindel.html("(n=" + data.count_snvindel + ")&nbsp;");
+      if (plot.mutation_count.sv) plot.mutation_count.sv.html("(n=" + data.count_sv + ")&nbsp;");
+      if (plot.mutation_count.fusion) plot.mutation_count.fusion.html("(n=" + data.count_fusion + ")&nbsp;");
+      if (plot.mutation_count.itd) plot.mutation_count.itd.html("(n=" + data.count_itd + ")&nbsp;");
+    }
+  }).catch((e) => {
+    obj.sayerror(e);
+  }).then(() => {
+    plot.button.text("Update plot").attr("disabled", null);
+  });
+}
+function show_dividerules(p, div) {
+  if (!p.samplerule.set) return;
+  const st = p.samplerule.set;
+  if (st.geneexpression) {
+    if (!st.bymedian && !st.byquartile) {
+      st.bymedian = 1;
+    }
+    const row = div.append("div").style("margin-bottom", "10px");
+    row.append("span").style("opacity", 0.5).html("Divide samples by " + st.gene + " expression with&nbsp;");
+    const s = row.append("select").on("change", (event) => {
+      const o = event.target.options[event.target.selectedIndex];
+      if (o.median) {
+        p.samplerule.set.bymedian = 1;
+        delete p.samplerule.set.byquartile;
+        span_quartilecompare.style("display", "none");
+      } else if (o.quartile) {
+        p.samplerule.set.byquartile = 1;
+        delete p.samplerule.set.bymedian;
+        span_quartilecompare.style("display", "inline");
+      }
+    });
+    s.append("option").text("median (group=2)").property("median", 1);
+    s.append("option").text("quartile (group=4)").property("quartile", 1);
+    const span_quartilecompare = row.append("span").style("margin-left", "10px");
+    span_quartilecompare.append("span").html("Compare each quartile against&nbsp;").style("opacity", 0.5);
+    {
+      const s2 = span_quartilecompare.append("select").on("change", (event) => {
+        delete p.samplerule.set.against1st;
+        delete p.samplerule.set.against4th;
+        switch (event.target.selectedIndex) {
+          case 0:
+            break;
+          case 1:
+            p.samplerule.set.against1st = 1;
+            break;
+          case 2:
+            p.samplerule.set.against4th = 1;
+            break;
+        }
+      });
+      s2.append("option").text("none");
+      s2.append("option").text("first quartile");
+      s2.append("option").text("fourth quartile");
+      if (st.against1st) {
+        s2.node().selectedIndex = 1;
+      } else if (s2.against4th) {
+        s2.node().selectedIndex = 2;
+      }
+    }
+    if (st.bymedian) {
+      s.node().selectedIndex = 0;
+      span_quartilecompare.style("display", "none");
+    } else if (st.byquartile) {
+      s.node().selectedIndex = 1;
+      span_quartilecompare.style("display", "inline");
+    }
+  }
+  if (st.mutation) {
+    p.mutation_count = {};
+    if (st.snvindel) {
+      const row = div.append("div").style("margin-bottom", "20px");
+      p.mutation_count.snvindel = row.append("span");
+      if (st.snvindel.name) {
+        row.append("span").html("SNV/indel&nbsp;");
+        const s = row.append("select");
+        s.append("option").text(st.snvindel.name).property("named", 1);
+        s.append("option").text("any mutation at " + st.chr + ":" + st.start);
+      } else {
+        row.append("span").text("SNV/indel at " + st.chr + ":" + (st.start == st.stop ? st.start : st.start + "-" + st.stop));
+      }
+    }
+    if (st.cnv) {
+      const row = div.append("div").style("margin-bottom", "20px");
+      p.mutation_count.cnv = row.append("span");
+      row.append("span").html(
+        "Copy number variation over " + st.chr + ":" + st.start + "-" + st.stop + ' <span style="font-size:.7em">' + bplen(st.stop - st.start) + "</span>&nbsp;"
+      );
+    }
+    if (st.loh) {
+      const row = div.append("div").style("margin-bottom", "20px");
+      p.mutation_count.loh = row.append("span");
+      row.append("span").html(
+        "LOH over " + st.chr + ":" + st.start + "-" + st.stop + ' <span style="font-size:.7em">' + bplen(st.stop - st.start) + "</span>&nbsp;"
+      );
+    }
+    if (st.sv) {
+      const row = div.append("div").style("margin-bottom", "20px");
+      p.mutation_count.sv = row.append("span");
+      row.append("span").html("SV at " + st.chr + ":" + (st.start == st.stop ? st.start : st.start + "-" + st.stop) + "&nbsp;");
+    }
+    if (st.fusion) {
+      const row = div.append("div").style("margin-bottom", "20px");
+      p.mutation_count.fusion = row.append("span");
+      row.append("span").html("Fusion at " + st.chr + ":" + (st.start == st.stop ? st.start : st.start + "-" + st.stop) + "&nbsp;");
+    }
+    if (st.itd) {
+      const row = div.append("div").style("margin-bottom", "20px");
+      p.mutation_count.itd = row.append("span");
+      row.append("span").html(
+        "ITD over " + st.chr + ":" + st.start + "-" + st.stop + ' <span style="font-size:.7em">' + bplen(st.stop - st.start) + "</span>&nbsp;"
+      );
+    }
+  }
+}
+function show_sampleinput(p, div) {
+  let rendered_flag = div.selectAll("div").size();
+  if (rendered_flag) return;
+  const row = div.append("div").style("margin-bottom", "10px");
+  const samplelist_div = row.append("div").style("margin-left", "20px");
+  samplelist_div.append("div").style("vertical-align", "top").style("display", "inline-block").style("opacity", 0.5).html("Enter sample names<br>(one sample per line) &nbsp;");
+  const sample_input = samplelist_div.append("textarea").style("display", "inline-block").attr("cols", "20").attr("rows", "10").on("change", () => {
+    let sampleset = p.samplerule.full.sampleset = [];
+    const str = sample_input.property("value").trim();
+    if (!str) return;
+    for (const sample of str.split("\n")) {
+      sampleset.push(sample);
+    }
+  });
+}
+export {
+  init
+};
+//# sourceMappingURL=mds.survivalplot-JV2JSH74.js.map

package/dist/multivalue-XTMXS2BA.js

@@ -0,0 +1,79 @@
+import {
+  getPillNameDefault,
+  set_hiddenvalues
+} from "./chunk-JP4IU7DO.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-IRAB3OI7.js";
+import "./chunk-CNFTQSNE.js";
+import "./chunk-RIHO7ZD5.js";
+import "./chunk-TVJOSRCH.js";
+import "./chunk-3CIL7KH7.js";
+import "./chunk-T4XPCSLP.js";
+import "./chunk-4TJO2DGU.js";
+import "./chunk-W5J3LTYS.js";
+import "./chunk-MHWYRNGA.js";
+import "./chunk-JHLF2ZC2.js";
+import "./chunk-WJLRU5OF.js";
+import "./chunk-HBNB5TRH.js";
+import "./chunk-PF4DSFDR.js";
+import "./chunk-4OLM3KSB.js";
+import "./chunk-PWYMHUXY.js";
+import "./chunk-TLT4YIG3.js";
+import "./chunk-5R63Q5KH.js";
+import "./chunk-I6Y4O3RR.js";
+import "./chunk-Q5RDQNIT.js";
+import "./chunk-HS5PO5ZQ.js";
+
+// termsetting/handlers/multivalue.ts
+function getHandler(self) {
+  return {
+    getPillName(d) {
+      return getPillNameDefault(self, d);
+    },
+    getPillStatus() {
+      const hidden = Object.keys(self.q?.hiddenValues || {}).length;
+      if (hidden) return { text: `${hidden} hidden` };
+    },
+    async showEditMenu(div) {
+      await makeCategoryMenu(self, div);
+    }
+  };
+}
+async function makeCategoryMenu(self, div) {
+  const data = await self.vocabApi.getCategories(self.term, self.filter);
+  const lst = (data.lst || []).sort((a, b) => b.samplecount - a.samplecount);
+  const holder = div.append("div").style("padding", "10px");
+  if (!lst.length) {
+    holder.append("div").style("opacity", 0.6).text("No categories");
+    return;
+  }
+  holder.append("div").style("opacity", 0.6).style("font-size", ".8em").style("padding-bottom", "5px").text("CHECK TO SHOW CATEGORY");
+  const checkboxes = /* @__PURE__ */ new Map();
+  for (const c of lst) {
+    const row = holder.append("div");
+    const label = row.append("label");
+    const checkbox = label.append("input").attr("type", "checkbox").property("checked", !self.q.hiddenValues?.[c.key]);
+    checkboxes.set(c.key, checkbox);
+    label.append("span").text(` ${c.label || c.key} `);
+    label.append("span").style("opacity", 0.6).style("font-size", ".8em").text(`n=${c.samplecount}`);
+  }
+  holder.append("button").style("margin-top", "10px").text("Apply").on("click", () => {
+    const hiddenValues = {};
+    for (const [key, checkbox] of checkboxes) {
+      if (!checkbox.property("checked")) hiddenValues[key] = 1;
+    }
+    self.q.hiddenValues = hiddenValues;
+    self.dom.tip.hide();
+    self.api.runCallback();
+  });
+}
+function fillTW(tw, _vocabApi) {
+  const q = tw.q;
+  if (!q.type) q.type = "values";
+  set_hiddenvalues(q, tw.term);
+}
+export {
+  fillTW,
+  getHandler
+};
+//# sourceMappingURL=multivalue-XTMXS2BA.js.map