@sjcrh/proteinpaint-client 2.217.0 → 2.218.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (977) hide show
  1. package/dist/2dmaf-BZWQ4YZF.js +1362 -0
  2. package/dist/AggMatrixInput-OXUENYYF.js +402 -0
  3. package/dist/AggregateMatrix-7PYLWY3X.js +37 -0
  4. package/dist/AppHeader-QOLLABH4.js +826 -0
  5. package/dist/BoxPlot-PDRYKWXF.js +1233 -0
  6. package/dist/CorrelationVolcano-Z3ABRHL6.js +613 -0
  7. package/dist/Cuminc-ATQT3KDO.js +1217 -0
  8. package/dist/DE-5LMMF5QB.js +85 -0
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  11. package/dist/DifferentialAnalysis-23WQKT6I.js +235 -0
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  18. package/dist/GeneExpInput-PW6HP5LO.js +38 -0
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  168. package/dist/condition-QROUALBG.js +323 -0
  169. package/dist/controls-GH37YWOP.js +30 -0
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  176. package/dist/dnaMethylation-2YU2HDD4.js +29 -0
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  849. /package/dist/{hierCluster-BJ5VBPXR.js.map → hierCluster-SU4BDK6I.js.map} +0 -0
  850. /package/dist/{hierCluster.config-4EERP4KK.js.map → hierCluster.config-4OZ65GKH.js.map} +0 -0
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  854. /package/dist/{imagePlot-4LMIKBVE.js.map → imagePlot-UYMWFNI4.js.map} +0 -0
  855. /package/dist/{importPlot-3CG6ASNH.js.map → importPlot-W3HPE4LZ.js.map} +0 -0
  856. /package/dist/{isoformExpression-VCDNKTZ6.js.map → isoformExpression-JEMJE5WY.js.map} +0 -0
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  860. /package/dist/{junction.customTerm-UOPUSEOE.js.map → junction.customTerm-MVSIUY66.js.map} +0 -0
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  866. /package/dist/{maftimeline-NABCAMHG.js.map → maftimeline-CRQEUTRY.js.map} +0 -0
  867. /package/dist/{matrix-JC6AJT2N.js.map → matrix-IBWB4A3Z.js.map} +0 -0
  868. /package/dist/{matrix-UCHESWVK.js.map → matrix-SOBGWBTY.js.map} +0 -0
  869. /package/dist/{matrix.cells-B4L42TBM.js.map → matrix.cells-GSKC6FXI.js.map} +0 -0
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  875. /package/dist/{matrix.layout-5DQNT7DD.js.map → matrix.layout-D6SRLAXS.js.map} +0 -0
  876. /package/dist/{matrix.legend-OY7IF6AS.js.map → matrix.legend-OWQAMHI2.js.map} +0 -0
  877. /package/dist/{matrix.renderers-GYOXGHPU.js.map → matrix.renderers-J66OAQUZ.js.map} +0 -0
  878. /package/dist/{matrix.serieses-657TLDAV.js.map → matrix.serieses-P5I4E2NB.js.map} +0 -0
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  886. /package/dist/{mds.survivalplot-AZ7LJDZZ.js.map → mds.survivalplot-MLRD27QP.js.map} +0 -0
  887. /package/dist/{multivalue-4QKGYYW2.js.map → multivalue-KJQCYBHA.js.map} +0 -0
  888. /package/dist/{numericDictTermCluster-GLLG6IK2.js.map → numericDictTermCluster-ZOU6R4XP.js.map} +0 -0
  889. /package/dist/{oncomatrix-R32ZPMX7.js.map → oncomatrix-4RHDDJDC.js.map} +0 -0
  890. /package/dist/{oncomatrix.spec-BMK6LMBS.js.map → oncomatrix.spec-JA6DT4PP.js.map} +0 -0
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  895. /package/dist/{plot.brainImaging-S7B547V4.js.map → plot.brainImaging-AZYEGF3U.js.map} +0 -0
  896. /package/dist/{plot.disco-K5MMC2GD.js.map → plot.disco-L6PGGZJI.js.map} +0 -0
  897. /package/dist/{plot.ssgq-B3OVMZFD.js.map → plot.ssgq-UM64SSXW.js.map} +0 -0
  898. /package/dist/{plot.vaf2cov-RBHDQULW.js.map → plot.vaf2cov-DKUKJRUP.js.map} +0 -0
  899. /package/dist/{polar2-GECELCTG.js.map → polar2-4YHPENAV.js.map} +0 -0
  900. /package/dist/{profileForms-2USYOA34.js.map → profileForms-KMECFO3K.js.map} +0 -0
  901. /package/dist/{profilePlot-YGD2CF6P.js.map → profilePlot-3AXSIXCK.js.map} +0 -0
  902. /package/dist/{proteinView-FCPWJLGU.js.map → proteinView-QWHOTL35.js.map} +0 -0
  903. /package/dist/{proteomeCohortCompare-TYYUF5A5.js.map → proteomeCohortCompare-DL2QLFL3.js.map} +0 -0
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  905. /package/dist/{pseudobulk-ZIN5VJGB.js.map → pseudobulk-IC525IZ2.js.map} +0 -0
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  907. /package/dist/{qualitative-N4F6NITI.js.map → qualitative-YY4NQGO5.js.map} +0 -0
  908. /package/dist/{radar2-X465RPJX.js.map → radar2-TJUPENQF.js.map} +0 -0
  909. /package/dist/{radarFacility2-AE7BA62N.js.map → radarFacility2-Q7LBWLCV.js.map} +0 -0
  910. /package/dist/{rememberedGvQ.unit.spec-4PDIU5RY.js.map → rememberedGvQ.unit.spec-2GBLM5AO.js.map} +0 -0
  911. /package/dist/{render-TD2QWOHT.js.map → render-AHR6SCQX.js.map} +0 -0
  912. /package/dist/{report-3Y2OWDF7.js.map → report-BPHJTRTO.js.map} +0 -0
  913. /package/dist/{sampleView-BUMMYRHJ.js.map → sampleView-CS2FB3K3.js.map} +0 -0
  914. /package/dist/{samplelst-BWK53BLI.js.map → samplelst-A3DHKP6U.js.map} +0 -0
  915. /package/dist/{samplematrix-RQU43UYR.js.map → samplematrix-5X7MFT3G.js.map} +0 -0
  916. /package/dist/{sc-LCBFWCZZ.js.map → sc-RCYXZMN6.js.map} +0 -0
  917. /package/dist/{scatter-6S5I7OW3.js.map → scatter-2ITGMX5N.js.map} +0 -0
  918. /package/dist/{scatter-MJELX75N.js.map → scatter-OAL4YOCA.js.map} +0 -0
  919. /package/dist/{selectGenomeWithTklst-WAVXHXR5.js.map → selectGenomeWithTklst-PB5KDW2N.js.map} +0 -0
  920. /package/dist/{singleCellCellType-WMCAJ7JF.js.map → singleCellCellType-FEFNOHOP.js.map} +0 -0
  921. /package/dist/{singleCellCellType.unit.spec-4Z46ZT5Q.js.map → singleCellCellType.unit.spec-V2I32V23.js.map} +0 -0
  922. /package/dist/{singleCellGeneExpression-7Q5ZJT4R.js.map → singleCellGeneExpression-RUQQMKDE.js.map} +0 -0
  923. /package/dist/{singleCellGeneExpression.unit.spec-6C7PDGRH.js.map → singleCellGeneExpression.unit.spec-VCMJRMT7.js.map} +0 -0
  924. /package/dist/{singleCellNumericValue-QGYITZRC.js.map → singleCellNumericValue-JLXZQWNT.js.map} +0 -0
  925. /package/dist/{singleCellNumericValue.unit.spec-MQUKPEZJ.js.map → singleCellNumericValue.unit.spec-XVCZEN5K.js.map} +0 -0
  926. /package/dist/{singleCellPlot-JJMFJ2KQ.js.map → singleCellPlot-4EBYWOJ2.js.map} +0 -0
  927. /package/dist/{singlecell-J23S3JR2.js.map → singlecell-UKZJAYVH.js.map} +0 -0
  928. /package/dist/{singlecell-Y4OGUWEC.js.map → singlecell-VNRWPXGV.js.map} +0 -0
  929. /package/dist/{snp-IO6TKWGD.js.map → snp-2RJDJQZC.js.map} +0 -0
  930. /package/dist/{snp.unit.spec-X7ILEEPO.js.map → snp.unit.spec-Z4DNBFAH.js.map} +0 -0
  931. /package/dist/{snplocus-Z2NGIKMO.js.map → snplocus-OZLIZ7R7.js.map} +0 -0
  932. /package/dist/{snplst-XCS2FCQV.js.map → snplst-EVRJ4OCL.js.map} +0 -0
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  934. /package/dist/{spliceevent.exonskip.diagram-AXCDJKH4.js.map → spliceevent.exonskip.diagram-WBNFLW4V.js.map} +0 -0
  935. /package/dist/{spliceevent.noeventdiagram-UK3X667E.js.map → spliceevent.noeventdiagram-EI72A6L3.js.map} +0 -0
  936. /package/dist/{ssGSEA-ZRPNQKJ5.js.map → ssGSEA-NONMMNF7.js.map} +0 -0
  937. /package/dist/{ssGSEA.unit.spec-DG5ZHLC7.js.map → ssGSEA.unit.spec-7JDPNLZA.js.map} +0 -0
  938. /package/dist/{stattable-XYSC3CYU.js.map → stattable-NNUHKPF4.js.map} +0 -0
  939. /package/dist/{studyCatalog-Y75LMI62.js.map → studyCatalog-KMLE7Q55.js.map} +0 -0
  940. /package/dist/{summarizeCnvGeneexp-H2NP7VLU.js.map → summarizeCnvGeneexp-AHCGPQLE.js.map} +0 -0
  941. /package/dist/{summarizeGeneexpSurvival-HTCD3VQQ.js.map → summarizeGeneexpSurvival-NCST7HDQ.js.map} +0 -0
  942. /package/dist/{summarizeMutationCnv-UEGXWK2P.js.map → summarizeMutationCnv-VUTQYXO6.js.map} +0 -0
  943. /package/dist/{summarizeMutationDiagnosis-MJGWP7IT.js.map → summarizeMutationDiagnosis-TFU2HUHQ.js.map} +0 -0
  944. /package/dist/{summarizeMutationSurvival-55JW5LA6.js.map → summarizeMutationSurvival-F4CJILS3.js.map} +0 -0
  945. /package/dist/{summary-HJO23RGB.js.map → summary-QQZW7BEE.js.map} +0 -0
  946. /package/dist/{summary.integration.spec-OWI2C2N5.js.map → summary.integration.spec-FILIPD3W.js.map} +0 -0
  947. /package/dist/{summaryInput-RL2JXRDE.js.map → summaryInput-RMY226Y3.js.map} +0 -0
  948. /package/dist/{sunburst-JFY6V5E2.js.map → sunburst-Y4LNCKMR.js.map} +0 -0
  949. /package/dist/{survival-PBBU6PA5.js.map → survival-4FYQHQHX.js.map} +0 -0
  950. /package/dist/{survival-6FLR4YCJ.js.map → survival-6GC267GY.js.map} +0 -0
  951. /package/dist/{survival.integration.spec-WAKTGYGP.js.map → survival.integration.spec-5ERXR6MG.js.map} +0 -0
  952. /package/dist/{svg2pdf.es.min-NIFE2BIE.js.map → svg2pdf.es.min-KKHWPFWG.js.map} +0 -0
  953. /package/dist/{svgraph-WD3DUZV7.js.map → svgraph-XIQIA7OJ.js.map} +0 -0
  954. /package/dist/{swimmer-VPKSBV6V.js.map → swimmer-643B5Q6F.js.map} +0 -0
  955. /package/dist/{table-GX3VJLPZ.js.map → table-JQIBRXTJ.js.map} +0 -0
  956. /package/dist/{termCollection-YQ332WKB.js.map → termCollection-LU5NW6KT.js.map} +0 -0
  957. /package/dist/{termCollection-QE7U5QBD.js.map → termCollection-XZCPBXRV.js.map} +0 -0
  958. /package/dist/{termCollection.unit.spec-ELLN7VRA.js.map → termCollection.unit.spec-H5LBV3N4.js.map} +0 -0
  959. /package/dist/{termCollectionFractionSelection-V3RP5KAT.js.map → termCollectionFractionSelection-3YHOFXEL.js.map} +0 -0
  960. /package/dist/{termCollectionFractionSelection.unit.spec-JR7Q7TJI.js.map → termCollectionFractionSelection.unit.spec-G5X3Y5YI.js.map} +0 -0
  961. /package/dist/{tk-J5VPFEX6.js.map → tk-NPWNBXLB.js.map} +0 -0
  962. /package/dist/{tk-GD2KJM5W.js.map → tk-YSW5NPW2.js.map} +0 -0
  963. /package/dist/{tvs.categorical-RPACB4VU.js.map → tvs.categorical-TUX6KRZI.js.map} +0 -0
  964. /package/dist/{tvs.condition-O6JBUM6D.js.map → tvs.condition-2CH25PLO.js.map} +0 -0
  965. /package/dist/{tvs.dt-5EVBSRX3.js.map → tvs.dt-YKP3F75O.js.map} +0 -0
  966. /package/dist/{tvs.dtcnv.categorical-Y5YHBZNC.js.map → tvs.dtcnv.categorical-QBJWJNHZ.js.map} +0 -0
  967. /package/dist/{tvs.dtcnv.continuous-WP322QUP.js.map → tvs.dtcnv.continuous-MV25OLBD.js.map} +0 -0
  968. /package/dist/{tvs.dtfusion-CCMUFDMQ.js.map → tvs.dtfusion-SJ64HNKE.js.map} +0 -0
  969. /package/dist/{tvs.dtitd-P3ED3MWA.js.map → tvs.dtitd-WQLHZK2P.js.map} +0 -0
  970. /package/dist/{tvs.dtsnvindel-X2MXPLC6.js.map → tvs.dtsnvindel-WMFJ7W7U.js.map} +0 -0
  971. /package/dist/{tvs.dtsv-4FOWFNVV.js.map → tvs.dtsv-GKEC5OGA.js.map} +0 -0
  972. /package/dist/{tvs.multivalue-IRF467ZK.js.map → tvs.multivalue-LFWMQETN.js.map} +0 -0
  973. /package/dist/{tvs.numeric-C7FDCGCS.js.map → tvs.numeric-63NVZG7U.js.map} +0 -0
  974. /package/dist/{tvs.samplelst-CBU6ATI5.js.map → tvs.samplelst-DEMMYRKK.js.map} +0 -0
  975. /package/dist/{tvs.survival-3K5ASAXV.js.map → tvs.survival-M4QUVP5L.js.map} +0 -0
  976. /package/dist/{tvs.termCollection-MXEWO6KJ.js.map → tvs.termCollection-J367GZY3.js.map} +0 -0
  977. /package/dist/{vocabulary-GQBHDP3K.js.map → vocabulary-RAVWS5IS.js.map} +0 -0
@@ -1,274 +0,0 @@
1
- import {
2
- LegendCircleReference,
3
- PlotBase,
4
- addGeneSearchbox
5
- } from "./chunk-NNDKYTUV.js";
6
- import "./chunk-HJ6L54YS.js";
7
- import "./chunk-HWNQOADC.js";
8
- import {
9
- Menu
10
- } from "./chunk-CNFTQSNE.js";
11
- import "./chunk-PLFPXOGX.js";
12
- import "./chunk-EEB5VE2A.js";
13
- import "./chunk-3CIL7KH7.js";
14
- import "./chunk-T4XPCSLP.js";
15
- import {
16
- dofetch3
17
- } from "./chunk-BIJOXCLN.js";
18
- import "./chunk-W5J3LTYS.js";
19
- import "./chunk-L2WOLNZK.js";
20
- import "./chunk-AMW5LCUB.js";
21
- import "./chunk-ZPWBYHNE.js";
22
- import {
23
- copyMerge,
24
- getCompInit
25
- } from "./chunk-HBNB5TRH.js";
26
- import "./chunk-PF4DSFDR.js";
27
- import {
28
- linear,
29
- sqrt
30
- } from "./chunk-4OLM3KSB.js";
31
- import "./chunk-6XKAOSQE.js";
32
- import "./chunk-TLT4YIG3.js";
33
- import "./chunk-5R63Q5KH.js";
34
- import "./chunk-I6Y4O3RR.js";
35
- import "./chunk-Q5RDQNIT.js";
36
- import "./chunk-HS5PO5ZQ.js";
37
-
38
- // plots/cellTypeBubbleHeatmap.ts
39
- var defaultConfig = { chartType: "cellTypeBubbleHeatmap" };
40
- var CELL_W = 84;
41
- var CELL_H = 60;
42
- var ROW_LABEL_W = 74;
43
- var GROUP_LABEL_H = 22;
44
- var GENO_LABEL_H = 40;
45
- var COL_LABEL_H = GROUP_LABEL_H + GENO_LABEL_H;
46
- var MIN_DOT_R = 8;
47
- var MAX_DOT_R = 22;
48
- var NEG_LOG_FDR_CAP = 10;
49
- var COLOR_NEG = "#762a83";
50
- var COLOR_ZERO = "#f7f7f7";
51
- var COLOR_POS = "#2166ac";
52
- var CellTypeBubbleHeatmap = class _CellTypeBubbleHeatmap extends PlotBase {
53
- constructor(opts, api) {
54
- super(opts, api);
55
- this.currentIsoform = "";
56
- this.type = _CellTypeBubbleHeatmap.type;
57
- }
58
- static {
59
- this.type = "cellTypeBubbleHeatmap";
60
- }
61
- async init() {
62
- const holder = this.opts.holder.append("div").style("padding", "10px");
63
- this.dom = {
64
- holder,
65
- body: holder.append("div"),
66
- tip: new Menu({ padding: "" }),
67
- header: this.opts.header
68
- };
69
- if (this.dom.header) this.dom.header.html("Cell-type Bubble Heatmap");
70
- }
71
- getState(appState) {
72
- const config = appState.plots.find((p) => p.id === this.id);
73
- if (!config) throw `No plot with id='${this.id}' found`;
74
- return { config };
75
- }
76
- async main() {
77
- const gene = this.state.config?.gene;
78
- if (!gene) throw new Error("cellTypeBubbleHeatmap: gene is missing");
79
- if (this.dom.header) this.dom.header.text(`Cell-type Bubble Heatmap: ${gene}`);
80
- const body = {
81
- genome: this.app.opts.state.vocab.genome,
82
- dslabel: this.app.opts.state.vocab.dslabel,
83
- gene
84
- };
85
- const data = await dofetch3("termdb/cellTypeBubbleHeatmap", { body });
86
- if (data.error) throw data.error;
87
- this.data = data;
88
- this.dom.body.selectAll("*").remove();
89
- const isoformIds = Object.keys(data.isoforms);
90
- if (isoformIds.length === 0) {
91
- this.dom.body.append("div").style("padding", "20px").style("color", "#666").text(`No data found for gene "${gene}" in any cohort DAPfile.`);
92
- return;
93
- }
94
- this.currentIsoform = isoformIds[0];
95
- const isoBlock = this.dom.body.append("div").style("margin-bottom", "12px");
96
- isoBlock.append("span").style("font-weight", "bold").text("Isoform: ");
97
- if (isoformIds.length > 1) {
98
- const sel = isoBlock.append("select").style("margin-left", "5px").style("padding", "3px 6px").on("change", () => {
99
- this.currentIsoform = sel.node().value;
100
- this.renderGrid();
101
- });
102
- sel.selectAll("option").data(isoformIds).enter().append("option").attr("value", (d) => d).text((d) => `${data.isoforms[d].gene_name} \u2014 ${d}`);
103
- } else {
104
- isoBlock.append("span").style("margin-left", "5px").text(`${data.isoforms[this.currentIsoform].gene_name} \u2014 ${this.currentIsoform}`);
105
- }
106
- this.gridHolder = this.dom.body.append("div");
107
- this.renderGrid();
108
- }
109
- renderGrid() {
110
- const data = this.data;
111
- const selectedIsoform = this.currentIsoform;
112
- const threshold = data.fdrThreshold;
113
- this.gridHolder.selectAll("*").remove();
114
- const container = this.gridHolder.append("div").style("display", "flex").style("gap", "24px").style("align-items", "flex-start").style("flex-wrap", "wrap");
115
- const isoformData = data.isoforms[selectedIsoform];
116
- if (!isoformData) return;
117
- const columns = data.columns;
118
- const rows = data.rows;
119
- const nCols = columns.length;
120
- const nRows = rows.length;
121
- const negLogFdr = (fdr) => fdr > 0 ? Math.min(-Math.log10(fdr), NEG_LOG_FDR_CAP) : NEG_LOG_FDR_CAP;
122
- const cellOf = (colKey, rowKey) => isoformData.data[colKey]?.[rowKey];
123
- let maxAbs = 0;
124
- const thresholdNegLog = negLogFdr(threshold);
125
- let maxNegLog = thresholdNegLog;
126
- for (const col of columns) {
127
- for (const row of rows) {
128
- const s = cellOf(col.key, row.key);
129
- if (!s) continue;
130
- const v = Math.abs(s.log2FC);
131
- if (v > maxAbs) maxAbs = v;
132
- const nl = negLogFdr(s.fdr);
133
- if (nl > maxNegLog) maxNegLog = nl;
134
- }
135
- }
136
- if (maxAbs === 0) maxAbs = 1;
137
- if (maxNegLog <= thresholdNegLog) maxNegLog = thresholdNegLog + 1;
138
- const colorScale = linear().domain([-maxAbs, 0, maxAbs]).range([COLOR_NEG, COLOR_ZERO, COLOR_POS]).clamp(true);
139
- const sizeScale = sqrt().domain([thresholdNegLog, maxNegLog]).range([MIN_DOT_R, MAX_DOT_R]).clamp(true);
140
- const gridW = ROW_LABEL_W + nCols * CELL_W + 20;
141
- const gridH = COL_LABEL_H + nRows * CELL_H + 20;
142
- const svg = container.append("svg").attr("width", gridW).attr("height", gridH).style("flex", "0 0 auto");
143
- const grid = svg.append("g");
144
- let c = 0;
145
- while (c < nCols) {
146
- const cellType = columns[c].cellType;
147
- let end = c;
148
- while (end + 1 < nCols && columns[end + 1].cellType === cellType) end++;
149
- const xStart = ROW_LABEL_W + c * CELL_W;
150
- const xEnd = ROW_LABEL_W + (end + 1) * CELL_W;
151
- const xMid = (xStart + xEnd) / 2;
152
- grid.append("text").attr("x", xMid).attr("y", GROUP_LABEL_H - 7).attr("text-anchor", "middle").attr("font-size", "13px").attr("font-weight", "bold").text(cellType);
153
- grid.append("line").attr("x1", xStart + 4).attr("y1", GROUP_LABEL_H - 3).attr("x2", xEnd - 4).attr("y2", GROUP_LABEL_H - 3).attr("stroke", "#bbb").attr("stroke-width", 1);
154
- c = end + 1;
155
- }
156
- for (let col = 0; col < nCols; col++) {
157
- const cx = ROW_LABEL_W + col * CELL_W + CELL_W / 2;
158
- grid.append("text").attr("x", cx).attr("y", COL_LABEL_H - 14).attr("text-anchor", "middle").attr("font-size", "12px").attr("font-weight", "600").text(columns[col].genotype);
159
- }
160
- for (let r = 0; r < nRows; r++) {
161
- const cy = COL_LABEL_H + r * CELL_H + CELL_H / 2;
162
- grid.append("text").attr("x", ROW_LABEL_W - 12).attr("y", cy).attr("text-anchor", "end").attr("dominant-baseline", "central").attr("font-size", "13px").attr("font-weight", "bold").text(rows[r].label);
163
- }
164
- for (let r = 0; r < nRows; r++) {
165
- for (let col = 0; col < nCols; col++) {
166
- const x0 = ROW_LABEL_W + col * CELL_W;
167
- const y0 = COL_LABEL_H + r * CELL_H;
168
- grid.append("rect").attr("x", x0).attr("y", y0).attr("width", CELL_W).attr("height", CELL_H).attr("fill", "none").attr("stroke", "#eee").attr("stroke-width", 1);
169
- const s = cellOf(columns[col].key, rows[r].key);
170
- if (!s) continue;
171
- const cx = x0 + CELL_W / 2;
172
- const cy = y0 + CELL_H / 2;
173
- grid.append("circle").attr("cx", cx).attr("cy", cy).attr("r", sizeScale(negLogFdr(s.fdr))).attr("fill", colorScale(s.log2FC)).attr("stroke", "#888").attr("stroke-width", 0.8).style("opacity", s.significant ? 1 : 0.35).on(
174
- "mouseover",
175
- (event) => this.showCellTip(event, isoformData.gene_name, selectedIsoform, columns[col], rows[r], s)
176
- ).on("mouseout", () => this.dom.tip.hide());
177
- }
178
- }
179
- this.renderLegend(container, colorScale, maxAbs, threshold, maxNegLog);
180
- }
181
- fmtFdr(v) {
182
- return v >= 1e-4 ? v.toFixed(4) : v.toExponential(2);
183
- }
184
- showCellTip(event, geneName, isoform, col, row, s) {
185
- this.dom.tip.clear().show(event.clientX, event.clientY);
186
- const t = this.dom.tip.d.append("div").style("padding", "8px").style("font-size", "13px");
187
- t.append("div").style("font-weight", "bold").style("margin-bottom", "4px").text(`${geneName} \u2014 ${isoform}`);
188
- t.append("div").text(`Cell type: ${col.cellType}`);
189
- t.append("div").text(`Genotype: ${col.genotype}`);
190
- t.append("div").text(`Timepoint: ${row.label}`);
191
- t.append("div").text(`Protein: ${s.id}`);
192
- t.append("div").text(`log\u2082FC: ${s.log2FC.toFixed(3)}`);
193
- t.append("div").text(`FDR: ${this.fmtFdr(s.fdr)}${s.significant ? "" : " (n.s.)"}`);
194
- t.append("div").style("color", "#666").style("margin-top", "4px").text("Color = log\u2082FC (blue up / purple down). Size = \u2212log\u2081\u2080 FDR.");
195
- }
196
- renderLegend(container, colorScale, maxAbs, threshold, maxNegLog) {
197
- const legend = container.append("div").style("display", "flex").style("flex-direction", "column").style("gap", "16px").style("padding", "8px 0").style("min-width", "180px").style("max-width", "260px");
198
- const colorBlock = legend.append("div");
199
- colorBlock.append("div").style("font-weight", "bold").style("font-size", "13px").style("margin-bottom", "6px").text("log\u2082FC");
200
- const cW = 22;
201
- const cH = 130;
202
- const cSvg = colorBlock.append("svg").attr("width", cW + 80).attr("height", cH + 16);
203
- const gid = `ctbh-grad-${this.id}`;
204
- const grad = cSvg.append("defs").append("linearGradient").attr("id", gid).attr("x1", "0").attr("y1", "0").attr("x2", "0").attr("y2", "1");
205
- const steps = 10;
206
- for (let i = 0; i <= steps; i++) {
207
- const t = i / steps;
208
- grad.append("stop").attr("offset", `${t * 100}%`).attr("stop-color", colorScale(maxAbs * (1 - 2 * t)));
209
- }
210
- cSvg.append("rect").attr("x", 0).attr("y", 8).attr("width", cW).attr("height", cH).style("fill", `url(#${gid})`).attr("stroke", "#999");
211
- const cScale = linear().domain([maxAbs, -maxAbs]).range([8, cH + 8]);
212
- for (const tick of [maxAbs, maxAbs / 2, 0, -maxAbs / 2, -maxAbs]) {
213
- const y = cScale(tick);
214
- cSvg.append("line").attr("x1", cW).attr("y1", y).attr("x2", cW + 5).attr("y2", y).attr("stroke", "#666");
215
- cSvg.append("text").attr("x", cW + 8).attr("y", y).attr("dominant-baseline", "central").attr("font-size", "10px").text(`${tick > 0 ? "+" : ""}${tick.toFixed(2)}`);
216
- }
217
- colorBlock.append("div").style("font-size", "11px").style("color", "#666").style("margin-top", "2px").text("blue = up (+), purple = down (\u2212)");
218
- const sizeBlock = legend.append("div");
219
- sizeBlock.append("div").style("font-weight", "bold").style("font-size", "13px").style("margin-bottom", "6px").text("Dot size: significance (\u2212log\u2081\u2080 FDR)");
220
- const sSvg = sizeBlock.append("svg");
221
- const sG = sSvg.append("g");
222
- new LegendCircleReference({
223
- g: sG,
224
- inputMin: 0,
225
- inputMax: MAX_DOT_R * 2,
226
- minRadius: MIN_DOT_R,
227
- maxRadius: MAX_DOT_R,
228
- minLabel: Number(Math.min(-Math.log10(threshold), NEG_LOG_FDR_CAP).toFixed(1)),
229
- maxLabel: Number(maxNegLog.toFixed(1))
230
- });
231
- const sPad = 4;
232
- const sBox = sG.node().getBBox();
233
- sG.attr("transform", `translate(${sPad - sBox.x}, ${sPad - sBox.y})`);
234
- sSvg.attr("width", Math.ceil(sBox.width + 2 * sPad)).attr("height", Math.ceil(sBox.height + 2 * sPad));
235
- const notes = legend.append("div").style("font-size", "11px").style("color", "#666").style("line-height", "1.5").style("max-width", "240px").style("overflow-wrap", "break-word");
236
- notes.append("div").text(
237
- `Color = log\u2082FC (blue up, purple down). Dot size = significance, \u2212log\u2081\u2080 FDR; the smallest size marks the FDR < ${threshold} cutoff. Non-significant dots (FDR \u2265 ${threshold}) are faded.`
238
- );
239
- notes.append("div").style("margin-top", "4px").text("An empty cell means the cohort was not assayed (e.g. OPC has no 4m) or the protein was not detected.");
240
- }
241
- };
242
- var componentInit = getCompInit(CellTypeBubbleHeatmap);
243
- async function getPlotConfig(opts) {
244
- const config = structuredClone(defaultConfig);
245
- if (!opts.gene) throw new Error("cellTypeBubbleHeatmap requires opts.gene");
246
- return copyMerge(config, opts);
247
- }
248
- function makeChartBtnMenu(holder, chartsInstance) {
249
- const row = holder.append("div").style("padding", "5px");
250
- row.append("span").style("font-weight", "bold").text("Enter a gene name:");
251
- const geneSearch = addGeneSearchbox({
252
- row,
253
- genome: chartsInstance.app.opts.genome,
254
- tip: new Menu({ padding: "0px" }),
255
- searchOnly: "gene",
256
- callback: async () => {
257
- if (!geneSearch.geneSymbol) throw new Error("A valid gene selection is required");
258
- chartsInstance.dom.tip.hide();
259
- chartsInstance.app.dispatch({
260
- type: "plot_create",
261
- config: {
262
- chartType: "cellTypeBubbleHeatmap",
263
- gene: geneSearch.geneSymbol
264
- }
265
- });
266
- }
267
- });
268
- }
269
- export {
270
- componentInit,
271
- getPlotConfig,
272
- makeChartBtnMenu
273
- };
274
- //# sourceMappingURL=cellTypeBubbleHeatmap-N7NDE325.js.map
@@ -1,54 +0,0 @@
1
- import {
2
- addGeneSearchbox,
3
- getSCGEunit,
4
- getSampleAssayInfo
5
- } from "./chunk-NNDKYTUV.js";
6
- import {
7
- Menu
8
- } from "./chunk-CNFTQSNE.js";
9
- import {
10
- SINGLECELL_GENE_EXPRESSION
11
- } from "./chunk-ZPWBYHNE.js";
12
-
13
- // termdb/handlers/singleCellGeneExpression.ts
14
- var SearchHandler = class {
15
- async init(opts) {
16
- this.validateOpts(opts);
17
- this.callback = opts.callback;
18
- this.app = opts.app;
19
- const sample = opts.usecase?.specialCase?.config?.sample;
20
- const { genes: geneList } = await getSampleAssayInfo(this.app.vocabApi, sample);
21
- const holder = opts.holder.append("div").style("padding", "10px 0px");
22
- const geneSearch = addGeneSearchbox({
23
- tip: new Menu({ padding: "0px" }),
24
- genome: opts.genomeObj,
25
- geneList,
26
- row: holder,
27
- searchOnly: "gene",
28
- callback: () => this.selectGene(geneSearch.geneSymbol, sample)
29
- });
30
- }
31
- /**TODO: scge tw handler will validate that a sample is included. Need to resolve issue
32
- * with sample info not included.*/
33
- async selectGene(gene, sample) {
34
- if (!gene) throw new Error("No gene selected");
35
- const unit = getSCGEunit(this.app.vocabApi);
36
- const name = `${gene} ${unit}`;
37
- this.callback({ gene, name, type: SINGLECELL_GENE_EXPRESSION, sample });
38
- }
39
- validateOpts(opts) {
40
- if (opts.callback == null) throw new Error("callback is required");
41
- if (opts.app == null) throw new Error("app is required");
42
- if (opts.holder == null) throw new Error("holder is required");
43
- if (opts.genomeObj == null) throw new Error("genomeObj is required");
44
- if (opts.usecase == null) throw new Error("usecase is required");
45
- if (!opts.usecase?.specialCase?.config?.sample) {
46
- throw new Error("usecase.specialCase.config.sample is required for singleCellGeneExpression handler");
47
- }
48
- }
49
- };
50
-
51
- export {
52
- SearchHandler
53
- };
54
- //# sourceMappingURL=chunk-2FWSNJEN.js.map
@@ -1,34 +0,0 @@
1
- import {
2
- appInit
3
- } from "./chunk-NNDKYTUV.js";
4
- import {
5
- TermTypes
6
- } from "./chunk-ZPWBYHNE.js";
7
-
8
- // termdb/handlers/ssGSEA.ts
9
- var SearchHandler = class {
10
- async init(opts) {
11
- this.callback = opts.callback;
12
- this.app = opts.app;
13
- const genesetDbName = Object.keys(opts.genomeObj.termdbs || {})[0];
14
- if (!genesetDbName) throw "genesetDbName missing";
15
- await appInit({
16
- holder: opts.holder,
17
- state: {
18
- dslabel: genesetDbName,
19
- genome: opts.genomeObj.name,
20
- nav: { header_mode: "search_only" }
21
- },
22
- tree: {
23
- click_term: (term) => {
24
- this.callback({ id: term.id, type: TermTypes.SSGSEA, name: term.name });
25
- }
26
- }
27
- });
28
- }
29
- };
30
-
31
- export {
32
- SearchHandler
33
- };
34
- //# sourceMappingURL=chunk-2JIKMCJR.js.map
@@ -1,102 +0,0 @@
1
- import {
2
- getPlotConfig
3
- } from "./chunk-NYO7YANQ.js";
4
- import {
5
- fillTermWrapper
6
- } from "./chunk-NNDKYTUV.js";
7
- import {
8
- dictionaryNumericTypes,
9
- numericTypes
10
- } from "./chunk-AMW5LCUB.js";
11
- import {
12
- copyMerge
13
- } from "./chunk-HBNB5TRH.js";
14
-
15
- // plots/matrix/hierCluster.config.js
16
- async function getPlotConfig2(opts = {}, app) {
17
- opts.chartType = "hierCluster";
18
- if (dictionaryNumericTypes.has(opts.dataType) || opts.dataType == "numericDictTerm") {
19
- const grp = opts.termgroups?.find((g) => g.type == "hierCluster");
20
- for (const tw of grp?.lst || []) tw.q = { ...tw.q, mode: "continuous" };
21
- }
22
- const config = await getPlotConfig(opts, app);
23
- delete config.genes;
24
- if (config.dataType == "numericDictTerm") {
25
- const lst = config.termgroups?.find((g) => g.type == "hierCluster")?.lst;
26
- config.dataType = lst?.[0]?.term?.type || "float";
27
- }
28
- config.settings.hierCluster = {
29
- /* type of data used for clustering
30
- exciting todo: (to introduce new dt values)
31
- - gene dependency
32
- - numeric dic term
33
- - non-gene genomic stuff that resolves into numeric quantities (cpg meth)
34
- - metabolite
35
- */
36
- dataType: config.dataType,
37
- // adjust the default group name based on automatically detected term types
38
- // Done in matrix.cells.js: setHierClusterCellProps
39
- // termGroupName: 'Expression',
40
- clusterSamples: true,
41
- clusterRows: true,
42
- clusterMethod: "average",
43
- // complete
44
- distanceMethod: "euclidean",
45
- zScoreCap: 5,
46
- zScoreTransformation: true,
47
- xDendrogramHeight: 100,
48
- yDendrogramHeight: 200,
49
- colorScale: "blueWhiteRed"
50
- };
51
- const overrides = app.vocabApi.termdbConfig.hierCluster || {};
52
- const numericDictTermClusterOverrides = dictionaryNumericTypes.has(config.dataType) && app.vocabApi.termdbConfig.numericDictTermCluster ? app.vocabApi.termdbConfig.numericDictTermCluster : {};
53
- copyMerge(
54
- config.settings.hierCluster,
55
- overrides.settings,
56
- opts.settings?.hierCluster || {},
57
- numericDictTermClusterOverrides.settings
58
- );
59
- {
60
- const c = config.settings.hierCluster.colorScale;
61
- if (!c) throw "colorScale missing";
62
- }
63
- config.settings.matrix.collabelpos = "top";
64
- const termGroupName = config.settings.hierCluster.termGroupName;
65
- const hcTermGroup = config.termgroups.find((g) => g.type == "hierCluster" || g.name == termGroupName) || {
66
- name: termGroupName
67
- };
68
- hcTermGroup.type = "hierCluster";
69
- if (!hcTermGroup.lst?.length) {
70
- if (!Array.isArray(opts.terms)) throw "opts.terms[] not array (may show geneset edit ui)";
71
- const promises = [];
72
- for (const i of opts.terms) {
73
- const tw = i.term ? i : { term: i };
74
- if (!tw.term.type) {
75
- if (config.dataType && numericTypes.has(config.dataType)) {
76
- tw.term.type = config.dataType;
77
- } else {
78
- throw `term type missing and cannot be assigned by dataType '${config.dataType}'`;
79
- }
80
- } else if (!numericTypes.has(tw.term.type)) {
81
- throw "term type is not numeric";
82
- } else if (config.dataType && !canTermBeInHierGrp(config.dataType, tw.term.type)) {
83
- throw `cannot have term type ${tw.term.type} in ${config.dataType} term group`;
84
- }
85
- if (dictionaryNumericTypes.has(tw.term.type)) tw.q = { ...tw.q, mode: "continuous" };
86
- promises.push(fillTermWrapper(tw, app.vocabApi));
87
- }
88
- hcTermGroup.lst = await Promise.all(promises);
89
- if (config.termgroups.indexOf(hcTermGroup) == -1) config.termgroups.unshift(hcTermGroup);
90
- }
91
- config.settings.matrix.maxSample = 1e5;
92
- return config;
93
- }
94
- function canTermBeInHierGrp(grpType, twType) {
95
- if (dictionaryNumericTypes.has(grpType) && dictionaryNumericTypes.has(twType)) return true;
96
- return twType == grpType;
97
- }
98
-
99
- export {
100
- getPlotConfig2 as getPlotConfig
101
- };
102
- //# sourceMappingURL=chunk-3SPEW6R6.js.map
@@ -1,123 +0,0 @@
1
- import {
2
- pickCollectionFraction,
3
- renderTable
4
- } from "./chunk-NNDKYTUV.js";
5
-
6
- // termdb/handlers/termCollection.ts
7
- var SearchHandler = class {
8
- async init(opts) {
9
- this.callback = opts.callback;
10
- this.app = opts.app;
11
- opts.holder.style("display", "");
12
- const termlst = opts.details.termlst ?? [];
13
- const memberType = opts.details.memberType || opts.details.type;
14
- if (opts.termCollectionSelectionMode === "fraction" && memberType === "numeric") {
15
- pickCollectionFraction({
16
- holder: opts.holder,
17
- term: makeTerm(opts.details, termlst, opts.usecase),
18
- callback: (tw) => opts.callback(tw)
19
- });
20
- return;
21
- }
22
- const tableDiv = opts.holder.append("div");
23
- renderTable({
24
- columns: [{ label: "VARIABLES" }],
25
- rows: termlst.map((t) => {
26
- return [{ value: t.name }];
27
- }),
28
- div: tableDiv,
29
- maxWidth: "30vw",
30
- maxHeight: "40vh",
31
- // the button is disabled while the selection cannot be submitted
32
- noButtonCallback: () => updateSelectBtn(),
33
- striped: false,
34
- showHeader: true,
35
- //false,
36
- selectAll: true,
37
- columnButtons: void 0,
38
- //Leave until table.js is typed
39
- buttons: void 0
40
- });
41
- let categoryTable;
42
- let ckSource = [];
43
- if (opts.details.categoryKeys) {
44
- ckSource = opts.details.categoryKeys;
45
- const categoryDiv = opts.holder.append("div").style("margin-top", "15px");
46
- const values = opts.details.termlst[0].values || {};
47
- categoryTable = categoryDiv.append("div");
48
- renderTable({
49
- columns: [{ label: "CATEGORIES" }],
50
- rows: ckSource.map((ck) => {
51
- return [{ value: values[ck.key]?.label ?? ck.key, checked: ck.shown }];
52
- }),
53
- div: categoryTable,
54
- maxWidth: "30vw",
55
- maxHeight: "40vh",
56
- noButtonCallback: () => updateSelectBtn(),
57
- striped: false,
58
- showHeader: true,
59
- //false,
60
- selectAll: true,
61
- columnButtons: void 0,
62
- //Leave until table.js is typed
63
- buttons: void 0
64
- });
65
- }
66
- function getRowChecks(div) {
67
- const trs = div.select("table").select("tbody").node().querySelectorAll("tr");
68
- return [...trs].map((tr) => tr.querySelectorAll("td")[1]?.querySelector("input")?.checked === true);
69
- }
70
- function getSelectedTermlst() {
71
- const checked = getRowChecks(tableDiv);
72
- return termlst.filter((term, i) => checked[i]);
73
- }
74
- function getCategoryKeys() {
75
- if (!categoryTable) return void 0;
76
- const checked = getRowChecks(categoryTable);
77
- return ckSource.map((ck, i) => ({ key: ck.key, shown: checked[i] }));
78
- }
79
- function getSelectionError() {
80
- if (getSelectedTermlst().length < 2) return "Select at least two variables.";
81
- if (getCategoryKeys()?.every((ck) => !ck.shown)) return "Select at least one category.";
82
- return void 0;
83
- }
84
- function updateSelectBtn() {
85
- if (!selectBtn) return;
86
- const error = getSelectionError();
87
- selectBtn.property("disabled", Boolean(error)).attr("title", error || null);
88
- }
89
- const selectBtn = opts.holder.append("div").style("float", "right").style("padding", "6px 20px").append("button").attr("data-testid", "sjpp-term-collection-select").text("Select").on("click", () => {
90
- opts.callback({
91
- // makeTerm() extracts propsByTermId (color, etc) for the selected terms
92
- ...makeTerm(opts.details, getSelectedTermlst(), opts.usecase),
93
- categoryKeys: getCategoryKeys()
94
- });
95
- });
96
- updateSelectBtn();
97
- }
98
- };
99
- function makeTerm(details, termlst, usecase) {
100
- const propsByTermId = {};
101
- if (details.propsByTermId) {
102
- for (const term of termlst) {
103
- if (details.propsByTermId[term.id]) propsByTermId[term.id] = details.propsByTermId[term.id];
104
- }
105
- }
106
- return {
107
- type: "termCollection",
108
- termIds: termlst.map((term) => term.id),
109
- termlst,
110
- name: details.name,
111
- valueTransform: details.valueTransformByPlots?.[usecase?.target],
112
- // memberType = ds.cohort.termdb.termCollections[].type for client code
113
- memberType: details.memberType || details.type,
114
- categoryKeys: details.categoryKeys,
115
- isleaf: true,
116
- propsByTermId
117
- };
118
- }
119
-
120
- export {
121
- SearchHandler
122
- };
123
- //# sourceMappingURL=chunk-5G6O5RYM.js.map