@sjcrh/proteinpaint-client 2.210.1 → 2.211.1-0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/2dmaf-A4CD7IRB.js +1367 -0
- package/dist/AggMatrixInput-4FU3FARW.js +406 -0
- package/dist/AggregateMatrix-7ODO25TE.js +41 -0
- package/dist/AppHeader-F7QNSLZX.js +830 -0
- package/dist/BoxPlot-UOT477UK.js +1208 -0
- package/dist/BoxPlot-UOT477UK.js.map +7 -0
- package/dist/CorrelationVolcano-7NG7MESL.js +617 -0
- package/dist/Cuminc-MLVPUTBL.js +1219 -0
- package/dist/DE-D5K7ZSDS.js +89 -0
- package/dist/DEinput-GC57ZRHF.js +501 -0
- package/dist/DM-SX37W5MO.js +90 -0
- package/dist/DifferentialAnalysis-GL3EXMSS.js +239 -0
- package/dist/Disco-NQFVZ3F7.js +3389 -0
- package/dist/Disco.UI-KDHXODP2.js +243 -0
- package/dist/DmrPlot-BJXEHPWV.js +362 -0
- package/dist/GB-SE4H3SUY.js +1392 -0
- package/dist/GSEA-JQSDBCFX.js +875 -0
- package/dist/GeneExpInput-T2UPRKCS.js +42 -0
- package/dist/Geomap-FCUFMRRQ.js +84 -0
- package/dist/HicApp-TGPJUD5E.js +2245 -0
- package/dist/IDCViewer-XF7NY5AX.js +10812 -0
- package/dist/NumBinaryEditor-AQB4DX7J.js +279 -0
- package/dist/NumBinaryEditor.unit.spec-DRCHAJMS.js +312 -0
- package/dist/NumContEditor-JZXX4LPN.js +105 -0
- package/dist/NumContEditor.unit.spec-7VYI7L6S.js +164 -0
- package/dist/NumCustomBinEditor-ZDZWFMXD.js +33 -0
- package/dist/NumCustomBinEditor.unit.spec-Z7MEQ4PL.js +397 -0
- package/dist/NumDiscreteEditor-7UDEFMTU.js +170 -0
- package/dist/NumDiscreteEditor.unit.spec-ECX3XR2H.js +233 -0
- package/dist/NumRegularBinEditor-MHR227NC.js +33 -0
- package/dist/NumRegularBinEditor.unit.spec-U7QMUCOW.js +278 -0
- package/dist/NumSplineEditor-7Y7BM5T2.js +210 -0
- package/dist/NumSplineEditor.unit.spec-QZIFXWCD.js +224 -0
- package/dist/NumericDensity-P53IIX73.js +33 -0
- package/dist/NumericDensity.unit.spec-SCI6QHZZ.js +418 -0
- package/dist/NumericHandler-5MGOKHSZ.js +34 -0
- package/dist/NumericHandler.unit.spec-NSXRTKIV.js +214 -0
- package/dist/ProteomeInput-EHVIYIER.js +388 -0
- package/dist/Regression-WMRNDDN5.js +1416 -0
- package/dist/RunChart2-2IHME6CX.js +749 -0
- package/dist/SC-H2S2V4J2.js +1181 -0
- package/dist/SC-H2S2V4J2.js.map +7 -0
- package/dist/Violin-TYMI7C32.js +1064 -0
- package/dist/Violin-TYMI7C32.js.map +7 -0
- package/dist/Volcano-UPFAQ2QD.js +2456 -0
- package/dist/Wsi-7O2VWVIZ.js +629 -0
- package/dist/adSandbox-7ZOACQFC.js +33 -0
- package/dist/animatedBubbleChart-ZNNVBPAP.js +547 -0
- package/dist/app-6UZZTYWD.js +32 -0
- package/dist/app-XV6VX2RC.js +42 -0
- package/dist/app.js +16 -16
- package/dist/bam-B3LNRPRZ.js +876 -0
- package/dist/barchart-XL7N35FL.js +42 -0
- package/dist/barchart2-HJJFWDIC.js +309 -0
- package/dist/block-XCJDVW4D.js +6250 -0
- package/dist/block.init-TJEAFIN6.js +33 -0
- package/dist/block.mds.expressionrank-JCR2LBYJ.js +354 -0
- package/dist/block.mds.geneboxplot-KWDQ2I7P.js +823 -0
- package/dist/block.mds.junction-T6HL3XF5.js +1539 -0
- package/dist/block.mds.svcnv-HC4ZJVUD.js +6796 -0
- package/dist/block.svg-46KWASKG.js +159 -0
- package/dist/block.tk.aicheck-X27AHMOE.js +278 -0
- package/dist/block.tk.ase-M4JC3COT.js +360 -0
- package/dist/block.tk.bam-7ME7VJTY.js +1901 -0
- package/dist/block.tk.bedgraphdot-PMUIWKPC.js +379 -0
- package/dist/block.tk.bigwig.ui-EN7LP656.js +206 -0
- package/dist/block.tk.hicstraw-G5MRNNWW.js +818 -0
- package/dist/block.tk.junction-RCEEIVA2.js +2358 -0
- package/dist/block.tk.junction.textmatrixui-37TYS332.js +194 -0
- package/dist/block.tk.ld-OTAFF5IF.js +94 -0
- package/dist/block.tk.menu-7MCI73LB.js +1024 -0
- package/dist/block.tk.pgv-BSS425TU.js +938 -0
- package/dist/brainImaging-764C6GUA.js +555 -0
- package/dist/brainRegions-ZAKFB4L4.js +217 -0
- package/dist/bubbleHeatmap-K5YLZG3K.js +378 -0
- package/dist/cellTypeBubbleHeatmap-C4FY4ND7.js +278 -0
- package/dist/chunk-2D2S3R7E.js +263 -0
- package/dist/chunk-2KZVUFUN.js +2902 -0
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- package/dist/chunk-4ENIOXIT.js +133 -0
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- package/dist/chunk-JPRCZTWX.js +255 -0
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- package/dist/chunk-UODENFH4.js.map +7 -0
- package/dist/chunk-UUWTID4M.js +480 -0
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- package/dist/cohort-JJ4KM2UE.js +70 -0
- package/dist/condition-IVZ4HSXX.js +327 -0
- package/dist/controls-WDHL4CM7.js +34 -0
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- package/dist/correlation-PVRGQZOJ.js +95 -0
- package/dist/customdata.inputui-J2HSIFO6.js +284 -0
- package/dist/dataDownload-T7ZFN4PI.js +329 -0
- package/dist/databrowser.ui-OED3QR3B.js +425 -0
- package/dist/dictionary-CWAPYHJO.js +113 -0
- package/dist/dnaMethylation-NRJYHYSA.js +33 -0
- package/dist/dnaMethylation.integration.spec-V57VHIFX.js +198 -0
- package/dist/dofetch-HLMSTOMY.js +48 -0
- package/dist/e2pca-EZNCZOV2.js +344 -0
- package/dist/ep-EZJ6BVXP.js +1249 -0
- package/dist/expclust.gdc.spec-IUBHBQDY.js +302 -0
- package/dist/facet-DNSSXX6H.js +519 -0
- package/dist/gb-BN4BUQLP.js +81 -0
- package/dist/geneExpClustering-PFOAZNTC.js +244 -0
- package/dist/geneExpression-3GQFWVJL.js +310 -0
- package/dist/geneExpression-UNTBGOXX.js +33 -0
- package/dist/geneExpression.unit.spec-UP2RCBDI.js +128 -0
- package/dist/geneORA-G6EPLJO2.js +273 -0
- package/dist/geneRanking-XKX4QC46.js +548 -0
- package/dist/geneVariant-WQWUPCHR.js +289 -0
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- package/dist/geneset-HJTUBPUW.js +203 -0
- package/dist/genomeBrowser.spec-4KUE7SEK.js +276 -0
- package/dist/grin2-5P4MLGIR.js +70 -0
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} else {
|
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183
|
-
}
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|
184
|
-
tk.leftlabels.doms.jug.text(`${tk.data.length} junction${tk.data.length > 1 ? "s" : ""}`);
|
|
185
|
-
const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
|
|
186
|
-
setColor(tk);
|
|
187
|
-
tk.sections.jug.g.selectAll("*").remove();
|
|
188
|
-
const mg = tk.sections.jug.g;
|
|
189
|
-
tk.data.sort((a, b) => {
|
|
190
|
-
return a._x - b._x;
|
|
191
|
-
});
|
|
192
|
-
const maxsamplecount = tk.data.reduce((max, j) => Math.max(max, j.sampleCount), 0);
|
|
193
|
-
{
|
|
194
|
-
const radius = 5;
|
|
195
|
-
let mrd = 0;
|
|
196
|
-
const w = Math.pow(radius, 2) * Math.PI;
|
|
197
|
-
if (maxsamplecount <= 10) {
|
|
198
|
-
mrd = w * maxsamplecount * 0.9;
|
|
199
|
-
} else if (maxsamplecount <= 100) {
|
|
200
|
-
mrd = w * 10;
|
|
201
|
-
} else if (maxsamplecount <= 1e3) {
|
|
202
|
-
mrd = w * 14;
|
|
203
|
-
} else {
|
|
204
|
-
mrd = w * 20;
|
|
205
|
-
}
|
|
206
|
-
const sf_discradius = linear().domain([
|
|
207
|
-
1,
|
|
208
|
-
maxsamplecount * 0.5 + 0.1,
|
|
209
|
-
maxsamplecount * 0.6 + 0.1,
|
|
210
|
-
maxsamplecount * 0.7 + 0.1,
|
|
211
|
-
maxsamplecount * 0.8 + 0.1,
|
|
212
|
-
maxsamplecount
|
|
213
|
-
]).range([w, w + (mrd - w) * 0.8, w + (mrd - w) * 0.85, w + (mrd - w) * 0.9, w + (mrd - w) * 0.95, mrd]);
|
|
214
|
-
let maxradius = 0;
|
|
215
|
-
for (const j of tk.data) {
|
|
216
|
-
j.radius = Math.sqrt(sf_discradius(j.sampleCount) / Math.PI);
|
|
217
|
-
if (j.sampleCount > 1) {
|
|
218
|
-
mg.append("text").attr("font-family", "Arial").attr("font-size", Math.max(minfontsize, j.radius)).text(j.sampleCount).each(function() {
|
|
219
|
-
const b = this.getBBox();
|
|
220
|
-
const newrad = Math.sqrt(Math.pow(b.width, 2) + Math.pow(b.height, 2)) / 2;
|
|
221
|
-
j.radius = Math.max(j.radius, newrad);
|
|
222
|
-
}).remove();
|
|
223
|
-
}
|
|
224
|
-
j.rimwidth = j.rimcount ? Math.max(2, j.radius / 6) : 0;
|
|
225
|
-
j.radius2 = j.radius + j.rimwidth + (j.rimwidth > 0 ? 1 : 0);
|
|
226
|
-
maxradius = Math.max(maxradius, j.radius2);
|
|
227
|
-
}
|
|
228
|
-
tk.maxradius = maxradius;
|
|
229
|
-
}
|
|
230
|
-
const maxmedian = tk.data.reduce((c, j) => Math.max(c, j.medianReadCount), 0);
|
|
231
|
-
tk.sections.jug.yscale = (tk.yscaleUseLog ? log() : linear()).domain([tk.readcountCutoff || 1, data.maxReadCount]).range([tk.sections.jug.axisheight, 0]);
|
|
232
|
-
for (const j of tk.data) {
|
|
233
|
-
if (j.axisy == void 0) {
|
|
234
|
-
j.axisy = tk.sections.jug.axisheight - tk.sections.jug.yscale(j.medianReadCount);
|
|
235
|
-
}
|
|
236
|
-
}
|
|
237
|
-
tk.sections.jug.height = tk.sections.jug.axisheight + tk.sections.jug.neckheight + tk.sections.jug.legheight;
|
|
238
|
-
mg.attr("transform", `translate(0,${tk.sections.jug.height})`);
|
|
239
|
-
{
|
|
240
|
-
const topy = -tk.sections.jug.legheight - tk.sections.jug.neckheight - tk.sections.jug.axisheight;
|
|
241
|
-
mg.append("line").attr("x1", 0).attr("y1", topy).attr("y2", topy).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
|
|
242
|
-
mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.axisheight).attr("y2", topy + tk.sections.jug.axisheight).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
|
|
243
|
-
let v = 10;
|
|
244
|
-
while (v <= data.maxReadCount) {
|
|
245
|
-
mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.yscale(v)).attr("y2", topy + tk.sections.jug.yscale(v)).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("stroke-dasharray", "4,4").attr("shape-rendering", "crispEdges");
|
|
246
|
-
v *= 10;
|
|
247
|
-
}
|
|
248
|
-
}
|
|
249
|
-
const jug = mg.selectAll().data(tk.data).enter().append("g").attr("class", "sja_jug").attr("transform", (d) => set_jug(d)).each(function(j) {
|
|
250
|
-
j.jugg = this;
|
|
251
|
-
});
|
|
252
|
-
jug.append("line").attr("stroke", (d) => d.color).attr("x1", (d) => set_leg_x1(d)).attr("y2", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg1").each(function(d) {
|
|
253
|
-
d.leg1 = this;
|
|
254
|
-
});
|
|
255
|
-
jug.append("line").attr("stroke", (d) => d.color).attr("x2", (d) => set_leg_x2(d)).attr("y1", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg2").each(function(d) {
|
|
256
|
-
d.leg2 = this;
|
|
257
|
-
});
|
|
258
|
-
const jug2 = jug.append("g").attr("class", "sja_jug_jug2").attr("transform", (d) => set_jug2(d, tk));
|
|
259
|
-
jug2.append("line").attr("stroke", (d) => d.color).attr("class", "sja_jug_stem").attr("stroke-dasharray", "2,2").attr("shape-rendering", "crispEdges").attr("y1", (d) => d.radius).attr("y2", (d) => {
|
|
260
|
-
return tk.sections.jug.neckheight + d.axisy;
|
|
261
|
-
}).attr("stroke-opacity", lineopacity).each(function(d) {
|
|
262
|
-
d.stem = this;
|
|
263
|
-
});
|
|
264
|
-
jug2.append("circle").each(function(d) {
|
|
265
|
-
d.disc = this;
|
|
266
|
-
}).attr("r", (d) => d.radius).attr("fill", (d) => d.color).attr("stroke", "white").attr("fill-opacity", discopacity);
|
|
267
|
-
jug2.filter((d) => d.sampleCount > 1).append("text").text((d) => d.sampleCount).attr("font-size", (d) => Math.max(minfontsize, d.radius)).attr("class", "sja_jug_discnum").attr("fill", "white").attr("font-family", "Arial").attr("text-anchor", "middle").attr("dominant-baseline", "central");
|
|
268
|
-
jug2.append("circle").attr("r", (d) => d.radius).attr("stroke", (d) => d.color).attr("fill", "white").attr("fill-opacity", 0).attr("stroke-opacity", 0).on("mouseover", (event, d) => {
|
|
269
|
-
event.stopPropagation();
|
|
270
|
-
select_default(d.disc).attr("fill-opacity", 0.8);
|
|
271
|
-
select_default(d.stem).attr("stroke-opacity", 1);
|
|
272
|
-
select_default(d.leg1).attr("stroke-opacity", 1);
|
|
273
|
-
select_default(d.leg2).attr("stroke-opacity", 1);
|
|
274
|
-
mouseoverSpanBackground(d, tk, block, viewpxwidth);
|
|
275
|
-
mouseoverBoxplot(d, tk);
|
|
276
|
-
const p = event.target.getBoundingClientRect();
|
|
277
|
-
tk.hovertip.clear().show(p.left + p.width, p.top - 50);
|
|
278
|
-
showOneJunction(d, tk, tk.hovertip.d, block);
|
|
279
|
-
}).on("mouseout", (event, d) => {
|
|
280
|
-
tk.hovertip.hide();
|
|
281
|
-
tk.pica.g.selectAll("*").remove();
|
|
282
|
-
block.cursorhlbar.attr("fill", block.cursorhlbarFillColor);
|
|
283
|
-
select_default(d.disc).attr("fill-opacity", discopacity);
|
|
284
|
-
select_default(d.stem).attr("stroke-opacity", lineopacity);
|
|
285
|
-
select_default(d.leg1).attr("stroke-opacity", lineopacity);
|
|
286
|
-
select_default(d.leg2).attr("stroke-opacity", lineopacity);
|
|
287
|
-
}).on("mousedown", (event) => {
|
|
288
|
-
event.stopPropagation();
|
|
289
|
-
}).on("mousemove", (event) => {
|
|
290
|
-
event.stopPropagation();
|
|
291
|
-
}).on("click", (event, d) => {
|
|
292
|
-
tk.hovertip.hide();
|
|
293
|
-
const p = event.target.getBoundingClientRect();
|
|
294
|
-
tk.itemtip.clear().show(p.left + p.width, p.top - 50);
|
|
295
|
-
showOneJunction(d, tk, tk.itemtip.d.append("div"), block, true);
|
|
296
|
-
});
|
|
297
|
-
doForceLayout(tk, block, viewpxwidth).then(() => {
|
|
298
|
-
set_all(tk);
|
|
299
|
-
axisstyle({
|
|
300
|
-
axis: tk.sections.jug.axis.transition().call(
|
|
301
|
-
axisRight().scale(tk.sections.jug.yscale).ticks(Math.floor(tk.sections.jug.axisheight / 20), ".0f")
|
|
302
|
-
),
|
|
303
|
-
color: "black",
|
|
304
|
-
showline: true
|
|
305
|
-
});
|
|
306
|
-
});
|
|
307
|
-
}
|
|
308
|
-
function rawdata2track(raw, tk, block) {
|
|
309
|
-
const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
|
|
310
|
-
const junctions = [];
|
|
311
|
-
for (const j of raw) {
|
|
312
|
-
if (j.sv && j.chr == j.sv.mate.chr) {
|
|
313
|
-
if (j.start > j.sv.mate.start) {
|
|
314
|
-
const p = j.start;
|
|
315
|
-
j.start = j.stop = j.sv.mate.start;
|
|
316
|
-
j.sv.mate.start = j.sv.mate.stop = p;
|
|
317
|
-
const q = j.strand;
|
|
318
|
-
j.strand = j.sv.mate.strand;
|
|
319
|
-
j.sv.mate.strand = q;
|
|
320
|
-
}
|
|
321
|
-
}
|
|
322
|
-
const e = j2block(j, block, viewpxwidth);
|
|
323
|
-
if (e) {
|
|
324
|
-
console.log(
|
|
325
|
-
"junction not in view range: " + j.chr + ":" + j.start + "-" + (j.sv ? j.sv.mate.chr + ":" + j.sv.mate.start : j.stop)
|
|
326
|
-
);
|
|
327
|
-
continue;
|
|
328
|
-
}
|
|
329
|
-
junctions.push(j);
|
|
330
|
-
}
|
|
331
|
-
if (tk.data) {
|
|
332
|
-
const map = /* @__PURE__ */ new Map();
|
|
333
|
-
tk.data.forEach((j) => map.set(j.chr + "." + j.start + "." + j.stop + "." + j.strand, j));
|
|
334
|
-
const pannedpx = Number.isInteger(block.pannedpx) ? block.pannedpx : 0;
|
|
335
|
-
for (const i of junctions) {
|
|
336
|
-
const j = map.get(i.chr + "." + i.start + "." + i.stop + "." + i.strand);
|
|
337
|
-
if (j) {
|
|
338
|
-
i.x = j.x + pannedpx;
|
|
339
|
-
i.axisy = j.axisy;
|
|
340
|
-
}
|
|
341
|
-
}
|
|
342
|
-
}
|
|
343
|
-
if (junctions.length == 0) {
|
|
344
|
-
return "no junctions in view range";
|
|
345
|
-
}
|
|
346
|
-
tk.data = junctions;
|
|
347
|
-
}
|
|
348
|
-
function j2block(j, block, viewpxwidth) {
|
|
349
|
-
let starthit;
|
|
350
|
-
let stophit;
|
|
351
|
-
{
|
|
352
|
-
const l = block.seekcoord(j.chr, j.start);
|
|
353
|
-
for (const hit of l) {
|
|
354
|
-
if (hit.ridx != void 0 && block.subpanels) {
|
|
355
|
-
if (hit.x < 0 || hit.x > block.width) {
|
|
356
|
-
continue;
|
|
357
|
-
}
|
|
358
|
-
}
|
|
359
|
-
starthit = hit;
|
|
360
|
-
}
|
|
361
|
-
}
|
|
362
|
-
{
|
|
363
|
-
const l = block.seekcoord(j.sv ? j.sv.mate.chr : j.chr, j.sv ? j.sv.mate.start : j.stop);
|
|
364
|
-
for (const hit of l) {
|
|
365
|
-
if (hit.ridx != void 0 && block.subpanels) {
|
|
366
|
-
if (hit.x < 0 || hit.x > block.width) {
|
|
367
|
-
continue;
|
|
368
|
-
}
|
|
369
|
-
}
|
|
370
|
-
stophit = hit;
|
|
371
|
-
}
|
|
372
|
-
}
|
|
373
|
-
if (starthit) {
|
|
374
|
-
if (!stophit) {
|
|
375
|
-
stophit = starthit;
|
|
376
|
-
}
|
|
377
|
-
} else {
|
|
378
|
-
if (stophit) {
|
|
379
|
-
starthit = stophit;
|
|
380
|
-
} else {
|
|
381
|
-
return true;
|
|
382
|
-
}
|
|
383
|
-
}
|
|
384
|
-
let startout = starthit.x < 0 || starthit.x > viewpxwidth;
|
|
385
|
-
let stopout = stophit.x < 0 || stophit.x > viewpxwidth;
|
|
386
|
-
if (startout && stopout) {
|
|
387
|
-
return true;
|
|
388
|
-
}
|
|
389
|
-
j.x0 = starthit.x;
|
|
390
|
-
j.x1 = stophit.x;
|
|
391
|
-
j.x = (j.x0 + j.x1) / 2;
|
|
392
|
-
j._x = j.x;
|
|
393
|
-
return false;
|
|
394
|
-
}
|
|
395
|
-
function setColor(tk) {
|
|
396
|
-
for (const j of tk.data) {
|
|
397
|
-
delete j.color;
|
|
398
|
-
j.color = JTypes[j.types[0]]?.color;
|
|
399
|
-
if (j.color == void 0) throw new Error("unknown j.type");
|
|
400
|
-
}
|
|
401
|
-
}
|
|
402
|
-
function set_jug(d) {
|
|
403
|
-
return "translate(" + d.x + ",0)";
|
|
404
|
-
}
|
|
405
|
-
function set_leg_x1(d) {
|
|
406
|
-
return d.x0 - d.x;
|
|
407
|
-
}
|
|
408
|
-
function set_leg_x2(d) {
|
|
409
|
-
return d.x1 - d.x;
|
|
410
|
-
}
|
|
411
|
-
function set_jug2(d, tk) {
|
|
412
|
-
return "translate(0,-" + (tk.sections.jug.legheight + tk.sections.jug.neckheight + d.axisy) + ")";
|
|
413
|
-
}
|
|
414
|
-
function set_all(tk) {
|
|
415
|
-
const mg = tk.sections.jug;
|
|
416
|
-
tk.data.forEach((j) => j.axisy = mg.axisheight - mg.yscale(j.medianReadCount));
|
|
417
|
-
const dur = 500;
|
|
418
|
-
mg.g.selectAll(".sja_jug_leg1").transition().duration(dur).attr("y2", -mg.legheight).attr("x1", (d) => set_leg_x1(d));
|
|
419
|
-
mg.g.selectAll(".sja_jug_leg2").transition().duration(dur).attr("y1", -mg.legheight).attr("x2", (d) => set_leg_x2(d));
|
|
420
|
-
mg.g.selectAll(".sja_jug_jug2").transition().duration(dur).attr("transform", (d) => set_jug2(d, tk));
|
|
421
|
-
mg.g.selectAll(".sja_jug").transition().duration(dur).attr("transform", (d) => set_jug(d));
|
|
422
|
-
mg.g.selectAll(".sja_jug_stem").transition().duration(dur).attr("y2", (d) => mg.neckheight + d.axisy);
|
|
423
|
-
}
|
|
424
|
-
function doForceLayout(tk, block, viewpxwidth) {
|
|
425
|
-
const nodes = [];
|
|
426
|
-
let sumdiscwidth = 0;
|
|
427
|
-
tk.data.map((j) => {
|
|
428
|
-
let tox;
|
|
429
|
-
if (j.x0 < 0) {
|
|
430
|
-
tox = j.x1 - j.radius2 * 2;
|
|
431
|
-
} else if (j.x1 > viewpxwidth) {
|
|
432
|
-
tox = j.x0 + j.radius2 * 2;
|
|
433
|
-
} else {
|
|
434
|
-
tox = j._x;
|
|
435
|
-
}
|
|
436
|
-
nodes.push({
|
|
437
|
-
junction: j,
|
|
438
|
-
tox,
|
|
439
|
-
x: tox,
|
|
440
|
-
y: tk.sections.jug.axisheight - tk.sections.jug.yscale(j.medianReadCount)
|
|
441
|
-
});
|
|
442
|
-
sumdiscwidth += j.radius2 * 2;
|
|
443
|
-
});
|
|
444
|
-
nodes.sort((i, j) => i.tox - j.tox);
|
|
445
|
-
nodes.forEach((n, i) => n.index = i);
|
|
446
|
-
const collidestrength = sumdiscwidth <= viewpxwidth ? 1 : viewpxwidth / sumdiscwidth;
|
|
447
|
-
return new Promise((resolve, reject) => {
|
|
448
|
-
simulation_default(nodes).force(
|
|
449
|
-
"y",
|
|
450
|
-
y_default((d) => {
|
|
451
|
-
return tk.sections.jug.axisheight - tk.sections.jug.yscale(d.junction.medianReadCount);
|
|
452
|
-
}).strength(1)
|
|
453
|
-
).force("x", x_default((d) => d.tox).strength(0.1)).force(
|
|
454
|
-
"collide",
|
|
455
|
-
collide_default((d) => {
|
|
456
|
-
return d.junction.radius2 + 2;
|
|
457
|
-
}).strength(collidestrength)
|
|
458
|
-
).alphaMin(0.5).on("end", () => {
|
|
459
|
-
nodes.forEach((n) => {
|
|
460
|
-
n.junction.x = n.x;
|
|
461
|
-
});
|
|
462
|
-
resolve();
|
|
463
|
-
});
|
|
464
|
-
});
|
|
465
|
-
}
|
|
466
|
-
function mouseoverSpanBackground(j, tk, block, viewpxwidth) {
|
|
467
|
-
let xleft = Math.min(j.x0, j.x1);
|
|
468
|
-
let xright = Math.max(j.x0, j.x1);
|
|
469
|
-
if (block.usegm && block.usegm.strand == "-") {
|
|
470
|
-
xleft = j.x1;
|
|
471
|
-
xright = j.x0;
|
|
472
|
-
}
|
|
473
|
-
if (xleft >= 0 && xright <= viewpxwidth) {
|
|
474
|
-
block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("y", 0).attr("width", xright - xleft).attr("height", block.totalheight()).attr("fill", "url(#" + tk.gradient4spanBackground.mid.id + ")");
|
|
475
|
-
return;
|
|
476
|
-
}
|
|
477
|
-
const boxwidth = 50;
|
|
478
|
-
if (xleft >= 0) {
|
|
479
|
-
block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("fill", "url(#" + tk.gradient4spanBackground.left.id + ")");
|
|
480
|
-
} else {
|
|
481
|
-
block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xright - boxwidth).attr("fill", "url(#" + tk.gradient4spanBackground.right.id + ")");
|
|
482
|
-
}
|
|
483
|
-
block.cursorhlbar.attr("y", 0).attr("width", boxwidth).attr("height", block.totalheight());
|
|
484
|
-
}
|
|
485
|
-
function mouseoverBoxplot(j, tk) {
|
|
486
|
-
if (!j.readcountBoxplot) return;
|
|
487
|
-
const color = "black";
|
|
488
|
-
const p5 = tk.sections.jug.yscale(j.readcountBoxplot[0]);
|
|
489
|
-
const p25 = tk.sections.jug.yscale(j.readcountBoxplot[1]);
|
|
490
|
-
const p50 = tk.sections.jug.yscale(j.readcountBoxplot[2]);
|
|
491
|
-
const p75 = tk.sections.jug.yscale(j.readcountBoxplot[3]);
|
|
492
|
-
const p95 = tk.sections.jug.yscale(j.readcountBoxplot[4]);
|
|
493
|
-
const w = 10;
|
|
494
|
-
tk.pica.g.selectAll("*").remove();
|
|
495
|
-
tk.pica.g.attr("transform", "translate(" + j.x + "," + p50 + ")");
|
|
496
|
-
const g = tk.pica.g.append("g").attr("transform", "translate(" + (-5 - w - j.radius2) + ",0)");
|
|
497
|
-
g.append("line").attr("x1", w / 2).attr("x2", w / 2).attr("y1", p95 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
498
|
-
g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p5 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
499
|
-
g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p95 - p50).attr("y2", p95 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
500
|
-
g.append("rect").attr("y", p75 - p50).attr("width", w).attr("height", p25 - p75).attr("stroke", color).attr("fill", "white").attr("shape-rendering", "crispEdges");
|
|
501
|
-
if (p25 - p75 > 3) {
|
|
502
|
-
g.append("line").attr("x2", w).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
503
|
-
}
|
|
504
|
-
}
|
|
505
|
-
function showOneJunction(j, tk, holder, block, isClickMenu = false) {
|
|
506
|
-
const table = table2col({ holder, margin: "0px" });
|
|
507
|
-
{
|
|
508
|
-
const [t12, t22] = table.addRow();
|
|
509
|
-
t12.text("Junction");
|
|
510
|
-
const div = t22.append("div");
|
|
511
|
-
if (!j.sv || j.chr == j.sv.mate.chr) {
|
|
512
|
-
div.html(
|
|
513
|
-
bplen(Math.abs(j.start - (j.sv ? j.sv.mate.start : j.stop))) + ' <span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + ((j.sv ? j.sv.mate.start : j.stop) + 1) + "</span>"
|
|
514
|
-
);
|
|
515
|
-
} else {
|
|
516
|
-
div.html(
|
|
517
|
-
'<span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + j.sv.mate.chr + ":" + (j.sv.mate.start + 1) + "</span>"
|
|
518
|
-
);
|
|
519
|
-
}
|
|
520
|
-
const d2 = t22.append("div");
|
|
521
|
-
d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", "#555").style("margin-right", "5px").text(j.strand);
|
|
522
|
-
if (j.info.site) {
|
|
523
|
-
d2.append("span").style("font-size", ".7em").style("margin-right", "5px").text(j.info.site);
|
|
524
|
-
}
|
|
525
|
-
for (const t of j.types) {
|
|
526
|
-
d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", JTypes[t]?.color || "black").style("margin-right", "5px").text(JTypes[t]?.name || "?");
|
|
527
|
-
}
|
|
528
|
-
}
|
|
529
|
-
const [t1, t2] = table.addRow();
|
|
530
|
-
if (j.sampleCount == 1) {
|
|
531
|
-
t1.text("Sample");
|
|
532
|
-
const sndiv = t2.append("div");
|
|
533
|
-
sndiv.text(j.sampleName || "single sample");
|
|
534
|
-
t2.append("div").html(j.medianReadCount + ' <span style="font-size:.7em">read count</span>');
|
|
535
|
-
} else {
|
|
536
|
-
t1.text("Samples");
|
|
537
|
-
t2.append("div").html(`${j.sampleCount} <span style="font-size:.7em">samples</span>
|
|
538
|
-
<br>${j.medianReadCount} <span style="font-size:.7em">median read count</span>`);
|
|
539
|
-
}
|
|
540
|
-
if (isClickMenu && tk.massApp) {
|
|
541
|
-
const [, buttonCell] = table.addRow();
|
|
542
|
-
buttonCell.append("button").attr("data-testid", "sjpp-junction-details").text("Details").on("click", async () => {
|
|
543
|
-
tk.itemtip.hide();
|
|
544
|
-
await tk.massApp.dispatch({
|
|
545
|
-
type: "plot_create",
|
|
546
|
-
config: {
|
|
547
|
-
chartType: "summary",
|
|
548
|
-
term: { term: makeJunctionTerm(j), q: { mode: "continuous" } }
|
|
549
|
-
}
|
|
550
|
-
});
|
|
551
|
-
});
|
|
552
|
-
buttonCell.append("button").attr("data-testid", "sjpp-junction-select").text("Select").on("click", async (event) => {
|
|
553
|
-
await addJunctionCustomTerm(tk, [makeJunctionTerm(j)], event.currentTarget, msgDiv);
|
|
554
|
-
});
|
|
555
|
-
const msgDiv = buttonCell.append("div").style("font-size", ".7em");
|
|
556
|
-
}
|
|
557
|
-
const type2elst = /* @__PURE__ */ new Map();
|
|
558
|
-
for (const e of j.info?.events || []) {
|
|
559
|
-
if (!type2elst.has(e.type)) type2elst.set(e.type, []);
|
|
560
|
-
type2elst.get(e.type).push(e);
|
|
561
|
-
}
|
|
562
|
-
for (const [type, elst] of type2elst) {
|
|
563
|
-
listAllEvents(elst, table, j, tk, block, isClickMenu);
|
|
564
|
-
}
|
|
565
|
-
if (type2elst.size == 0) {
|
|
566
|
-
const [t12, t22] = table.addRow();
|
|
567
|
-
t12.text("Diagram");
|
|
568
|
-
showJunctionDiagram(j, tk, t22);
|
|
569
|
-
}
|
|
570
|
-
}
|
|
571
|
-
function makeJunctionTerm(j) {
|
|
572
|
-
const position = `${j.chr}:${j.start + 1}-${j.stop + 1}`;
|
|
573
|
-
return {
|
|
574
|
-
type: TermTypes.JUNCTION,
|
|
575
|
-
id: `${j.chr}:${j.start}-${j.stop}:${j.strand}`,
|
|
576
|
-
name: j.name || `${position} (${j.strand})`,
|
|
577
|
-
chr: j.chr,
|
|
578
|
-
start: j.start,
|
|
579
|
-
stop: j.stop,
|
|
580
|
-
strand: j.strand,
|
|
581
|
-
info: j.info || {}
|
|
582
|
-
};
|
|
583
|
-
}
|
|
584
|
-
function showJunctionDiagram(j, tk, holder) {
|
|
585
|
-
if (typeof j.info != "object" || Object.keys(j.info).length == 0) {
|
|
586
|
-
return;
|
|
587
|
-
}
|
|
588
|
-
const leftgenes = /* @__PURE__ */ new Map();
|
|
589
|
-
if (j.info.exonleft) j.info.exonleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
590
|
-
if (j.info.exonleftin) j.info.exonleftin.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
591
|
-
if (j.info.intronleft) j.info.intronleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
592
|
-
const rightgenes = /* @__PURE__ */ new Map();
|
|
593
|
-
if (j.info.exonright) j.info.exonright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
594
|
-
if (j.info.exonrightin) j.info.exonrightin.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
595
|
-
if (j.info.intronright) j.info.intronright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
596
|
-
let isoform;
|
|
597
|
-
let strand;
|
|
598
|
-
if (leftgenes.size) {
|
|
599
|
-
if (rightgenes.size) {
|
|
600
|
-
for (const [n, a] of leftgenes) {
|
|
601
|
-
if (rightgenes.has(n)) {
|
|
602
|
-
isoform = n;
|
|
603
|
-
strand = a.strand;
|
|
604
|
-
break;
|
|
605
|
-
}
|
|
606
|
-
}
|
|
607
|
-
} else {
|
|
608
|
-
const a = [...leftgenes][0];
|
|
609
|
-
isoform = a[0];
|
|
610
|
-
strand = a[1].strand;
|
|
611
|
-
}
|
|
612
|
-
} else if (rightgenes.size) {
|
|
613
|
-
const a = [...rightgenes][0];
|
|
614
|
-
isoform = a[0];
|
|
615
|
-
strand = a[1].strand;
|
|
616
|
-
}
|
|
617
|
-
if (isoform) {
|
|
618
|
-
if (strand != "+" && strand != "-") {
|
|
619
|
-
holder.text("unknown strand for " + isoform);
|
|
620
|
-
return;
|
|
621
|
-
}
|
|
622
|
-
import("./spliceevent.noeventdiagram-L322N534.js").then((p) => {
|
|
623
|
-
p.samegene({
|
|
624
|
-
isoform,
|
|
625
|
-
reverse: strand == "-",
|
|
626
|
-
ongene: j.info,
|
|
627
|
-
holder
|
|
628
|
-
});
|
|
629
|
-
});
|
|
630
|
-
return;
|
|
631
|
-
}
|
|
632
|
-
import("./spliceevent.noeventdiagram-L322N534.js").then((p) => {
|
|
633
|
-
p.differentgenes({
|
|
634
|
-
ongene: j.info,
|
|
635
|
-
holder
|
|
636
|
-
});
|
|
637
|
-
});
|
|
638
|
-
}
|
|
639
|
-
function showEventdiagram_a53ss(j, e, tk, holder, block, isClickMenu) {
|
|
640
|
-
const e2 = {
|
|
641
|
-
junctionB: {
|
|
642
|
-
start: j.start,
|
|
643
|
-
stop: j.stop,
|
|
644
|
-
strand: j.strand,
|
|
645
|
-
v: j.medianReadCount
|
|
646
|
-
},
|
|
647
|
-
a5ss: e.type == JT_a5ss,
|
|
648
|
-
a3ss: e.type == JT_a3ss,
|
|
649
|
-
altinintron: e.altinintron,
|
|
650
|
-
altinexon: e.altinexon,
|
|
651
|
-
frame: e.frame,
|
|
652
|
-
exon5idx: e.exon5idx,
|
|
653
|
-
strand: e.strand,
|
|
654
|
-
sitedist: e.sitedist
|
|
655
|
-
};
|
|
656
|
-
const otherJs = [];
|
|
657
|
-
if (e.junctionA) {
|
|
658
|
-
e2.junctionA = { start: e.junctionA.start, stop: e.junctionA.stop, strand: e.junctionA.strand, v: "..." };
|
|
659
|
-
const aj = structuredClone(e.junctionA);
|
|
660
|
-
aj.name = `E${e.exon5idx + 1}-E${e.exon5idx + 1 + 1}`;
|
|
661
|
-
otherJs.push(aj);
|
|
662
|
-
}
|
|
663
|
-
if (isClickMenu) {
|
|
664
|
-
mayGroupSelect(tk, block, j, otherJs, `${e.gene} ${e.isoform} E${e.exon5idx + 1} ${e.type}`, holder);
|
|
665
|
-
}
|
|
666
|
-
import("./spliceevent.a53ss.diagram-FL2R6F22.js").then((p) => {
|
|
667
|
-
const text = p.default({
|
|
668
|
-
event: e2,
|
|
669
|
-
holder
|
|
670
|
-
});
|
|
671
|
-
if (!text) return;
|
|
672
|
-
setTimeout(() => {
|
|
673
|
-
if (text.node().getBoundingClientRect().top == 0) return;
|
|
674
|
-
const strandA = e.junctionA.strand;
|
|
675
|
-
fetchReadcount4junctionAbyjunctionBsamples(
|
|
676
|
-
tk,
|
|
677
|
-
block,
|
|
678
|
-
j,
|
|
679
|
-
/* @__PURE__ */ new Map([[e.junctionA.start + "." + e.junctionA.stop + "." + strandA, text]]),
|
|
680
|
-
[[e.junctionA.start, e.junctionA.stop, strandA]]
|
|
681
|
-
);
|
|
682
|
-
}, 1e3);
|
|
683
|
-
});
|
|
684
|
-
}
|
|
685
|
-
function showEventdiagram_skipalt_fetchreadcount(j, e, tk, holder, block, isClickMenu) {
|
|
686
|
-
const e2 = {
|
|
687
|
-
gm: {
|
|
688
|
-
// confirm if can delete
|
|
689
|
-
name: e.gene,
|
|
690
|
-
isoform: e.isoform
|
|
691
|
-
},
|
|
692
|
-
junctionB: {
|
|
693
|
-
data: [{ v: j.medianReadCount }]
|
|
694
|
-
},
|
|
695
|
-
skippedexon: e.skippedexon,
|
|
696
|
-
isskipexon: e.type == JT_exonskip,
|
|
697
|
-
isaltexon: e.type == JT_exonaltuse,
|
|
698
|
-
frame: e.frame,
|
|
699
|
-
junctionAlst: [],
|
|
700
|
-
color: "#99004d"
|
|
701
|
-
};
|
|
702
|
-
const otherJs = [];
|
|
703
|
-
const firstSkipped = Math.min(...e.skippedexon) + 1;
|
|
704
|
-
const lastSkipped = Math.max(...e.skippedexon) + 1;
|
|
705
|
-
if (e.junctionAlst) {
|
|
706
|
-
for (const [i, jA] of e.junctionAlst.entries()) {
|
|
707
|
-
if (jA) {
|
|
708
|
-
const aj = structuredClone(jA);
|
|
709
|
-
aj.name = `E${firstSkipped - 1 + i}-E${firstSkipped + i}`;
|
|
710
|
-
otherJs.push(aj);
|
|
711
|
-
jA.data = [{ v: "..." }];
|
|
712
|
-
e2.junctionAlst.push(jA);
|
|
713
|
-
continue;
|
|
714
|
-
}
|
|
715
|
-
e2.junctionAlst.push(null);
|
|
716
|
-
}
|
|
717
|
-
}
|
|
718
|
-
if (e.up1junction) {
|
|
719
|
-
const uj = structuredClone(e.up1junction);
|
|
720
|
-
uj.name = `E${firstSkipped - 2}-E${firstSkipped - 1}`;
|
|
721
|
-
otherJs.push(uj);
|
|
722
|
-
e.up1junction.data = [{ v: "..." }];
|
|
723
|
-
e2.up1junction = e.up1junction;
|
|
724
|
-
}
|
|
725
|
-
if (e.down1junction) {
|
|
726
|
-
const dj = structuredClone(e.down1junction);
|
|
727
|
-
dj.name = `E${lastSkipped + 1}-E${lastSkipped + 2}`;
|
|
728
|
-
otherJs.push(dj);
|
|
729
|
-
e.down1junction.data = [{ v: "..." }];
|
|
730
|
-
e2.down1junction = e.down1junction;
|
|
731
|
-
}
|
|
732
|
-
if (isClickMenu) {
|
|
733
|
-
const jc = structuredClone({
|
|
734
|
-
// duplicate j.info{} just in case
|
|
735
|
-
chr: j.chr,
|
|
736
|
-
start: j.start,
|
|
737
|
-
stop: j.stop,
|
|
738
|
-
strand: j.strand,
|
|
739
|
-
info: j.info
|
|
740
|
-
});
|
|
741
|
-
jc.name = `E${firstSkipped - 1}-E${lastSkipped + 1}`;
|
|
742
|
-
mayGroupSelect(
|
|
743
|
-
tk,
|
|
744
|
-
block,
|
|
745
|
-
jc,
|
|
746
|
-
otherJs,
|
|
747
|
-
`${e.gene} ${e.isoform} ${e.skippedexon.map((i) => "E" + (i + 1)).join(",")} ${e.type}`,
|
|
748
|
-
holder
|
|
749
|
-
);
|
|
750
|
-
}
|
|
751
|
-
import("./spliceevent.exonskip.diagram-XDZWTJXR.js").then((p) => {
|
|
752
|
-
const [junction2readcounttext, junctionlst] = p.default({
|
|
753
|
-
event: e2,
|
|
754
|
-
holder,
|
|
755
|
-
nophrase: true
|
|
756
|
-
});
|
|
757
|
-
setTimeout(() => {
|
|
758
|
-
for (const [k, text] of junction2readcounttext) {
|
|
759
|
-
if (text.node().getBoundingClientRect().top == 0) {
|
|
760
|
-
return;
|
|
761
|
-
}
|
|
762
|
-
}
|
|
763
|
-
fetchReadcount4junctionAbyjunctionBsamples(tk, block, j, junction2readcounttext, junctionlst);
|
|
764
|
-
}, 1e3);
|
|
765
|
-
});
|
|
766
|
-
}
|
|
767
|
-
function mayGroupSelect(tk, block, mainJ, otherJs, eventlabel, holder) {
|
|
768
|
-
if (!tk.massApp) return;
|
|
769
|
-
for (const j of otherJs) {
|
|
770
|
-
j.chr = mainJ.chr;
|
|
771
|
-
j.info = {
|
|
772
|
-
type: JT_canonical
|
|
773
|
-
};
|
|
774
|
-
}
|
|
775
|
-
holder.append("button").attr("data-testid", "sjpp-junction-select").text(`Select ${otherJs.length + 1} junctions`).on("click", async (event) => {
|
|
776
|
-
await addJunctionCustomTerm(
|
|
777
|
-
tk,
|
|
778
|
-
[makeJunctionTerm(mainJ), ...otherJs.map(makeJunctionTerm)],
|
|
779
|
-
event.currentTarget,
|
|
780
|
-
msgDiv,
|
|
781
|
-
eventlabel
|
|
782
|
-
);
|
|
783
|
-
});
|
|
784
|
-
const msgDiv = holder.append("div").style("font-size", ".7em");
|
|
785
|
-
}
|
|
786
|
-
async function addJunctionCustomTerm(tk, junctions, button, msgDiv, eventlabel) {
|
|
787
|
-
await tk.massApp.dispatch({
|
|
788
|
-
type: "add_customTerm",
|
|
789
|
-
obj: makeJunctionCustomTerm(junctions, eventlabel)
|
|
790
|
-
});
|
|
791
|
-
button.remove();
|
|
792
|
-
msgDiv.text(
|
|
793
|
-
eventlabel ? `${junctions.length} junctions can now be found through variable selection under ${eventlabel}.` : "This junction can now be found through variable selection."
|
|
794
|
-
);
|
|
795
|
-
}
|
|
796
|
-
function listAllEvents(lst, table, j, tk, block, isClickMenu) {
|
|
797
|
-
if (lst.length == 1) {
|
|
798
|
-
const [t1, t2] = table.addRow();
|
|
799
|
-
const e = lst[0];
|
|
800
|
-
t1.append("div").text(e.gene);
|
|
801
|
-
t1.append("div").text(e.isoform).style("font-size", ".8em");
|
|
802
|
-
if (e.type == JT_exonskip || e.type == JT_exonaltuse) {
|
|
803
|
-
showEventdiagram_skipalt_fetchreadcount(j, e, tk, t2, block, isClickMenu);
|
|
804
|
-
} else if (e.type == JT_a5ss || e.type == JT_a3ss) {
|
|
805
|
-
showEventdiagram_a53ss(j, e, tk, t2, block, isClickMenu);
|
|
806
|
-
}
|
|
807
|
-
return;
|
|
808
|
-
}
|
|
809
|
-
const map = /* @__PURE__ */ new Map();
|
|
810
|
-
for (const e of lst) {
|
|
811
|
-
const f = structuredClone(e);
|
|
812
|
-
const v = e.isoform;
|
|
813
|
-
delete f.isoform;
|
|
814
|
-
const key = JSON.stringify(f);
|
|
815
|
-
if (map.has(key)) map.get(key).push(e.isoform);
|
|
816
|
-
else map.set(key, [e.isoform]);
|
|
817
|
-
}
|
|
818
|
-
for (const [key, isolst] of map) {
|
|
819
|
-
const eo = JSON.parse(key);
|
|
820
|
-
eo.isoform = isolst[0];
|
|
821
|
-
const [t1, t2] = table.addRow();
|
|
822
|
-
t1.append("div").text(eo.gene);
|
|
823
|
-
{
|
|
824
|
-
const s = isolst.length >= 5 ? 0.7 : 0.8;
|
|
825
|
-
for (const i of isolst)
|
|
826
|
-
t1.append("div").text(i).style("font-size", s + "em");
|
|
827
|
-
}
|
|
828
|
-
if (eo.type == JT_exonskip || eo.type == JT_exonaltuse) {
|
|
829
|
-
showEventdiagram_skipalt_fetchreadcount(j, eo, tk, t2, block, isClickMenu);
|
|
830
|
-
} else if (eo.type == JT_a5ss || eo.type == JT_a3ss) {
|
|
831
|
-
showEventdiagram_a53ss(j, eo, tk, t2, block, isClickMenu);
|
|
832
|
-
}
|
|
833
|
-
}
|
|
834
|
-
}
|
|
835
|
-
async function fetchReadcount4junctionAbyjunctionBsamples(tk, block, jB, junction2readcounttext, jAlst) {
|
|
836
|
-
const [body, headers] = getParameter(tk, block);
|
|
837
|
-
delete body.rglst;
|
|
838
|
-
delete body.hiddenTypes;
|
|
839
|
-
body.junctionB = { chr: jB.chr, start: jB.start, stop: jB.stop, strand: jB.strand };
|
|
840
|
-
body.junctionAposlst = jAlst;
|
|
841
|
-
try {
|
|
842
|
-
const data = await dofetch3("termdb/junctions/AbyB", { body, headers });
|
|
843
|
-
if (data.error) throw new Error(data.error);
|
|
844
|
-
if (!Array.isArray(data.lst)) throw new Error(".lst[] missing");
|
|
845
|
-
for (const j of data.lst) {
|
|
846
|
-
const key = j.start + "." + j.stop + "." + j.strand;
|
|
847
|
-
if (junction2readcounttext.has(key)) {
|
|
848
|
-
junction2readcounttext.get(key).text(j.v);
|
|
849
|
-
}
|
|
850
|
-
}
|
|
851
|
-
} catch (e) {
|
|
852
|
-
console.error(e.message || e);
|
|
853
|
-
}
|
|
854
|
-
}
|
|
855
|
-
|
|
856
|
-
// j2/makeTk.js
|
|
857
|
-
async function makeTk(tk, block) {
|
|
858
|
-
if ("yscaleUseLog" in tk) {
|
|
859
|
-
if (typeof tk.yscaleUseLog != "boolean") throw new Error("tk.yscaleUseLog not boolean");
|
|
860
|
-
} else {
|
|
861
|
-
tk.yscaleUseLog = true;
|
|
862
|
-
}
|
|
863
|
-
if (tk.hiddentypes) {
|
|
864
|
-
if (typeof tk.hiddentypes != "string") throw new Error("tk.hiddentypes not string");
|
|
865
|
-
}
|
|
866
|
-
if (tk.readcountCutoff) {
|
|
867
|
-
if (!Number.isInteger(tk.readcountCutoff) || tk.readcountCutoff < 0)
|
|
868
|
-
throw new Error("tk.readcountCutoff is not positive integer");
|
|
869
|
-
} else {
|
|
870
|
-
tk.readcountCutoff = 0;
|
|
871
|
-
}
|
|
872
|
-
{
|
|
873
|
-
const pale = "#FFFEAB";
|
|
874
|
-
const dark = "#F7F69E";
|
|
875
|
-
const id1 = Math.random().toString();
|
|
876
|
-
const id2 = Math.random().toString();
|
|
877
|
-
const id3 = Math.random().toString();
|
|
878
|
-
const defs = tk.gleft.append("defs");
|
|
879
|
-
const left = defs.append("linearGradient").attr("id", id1);
|
|
880
|
-
left.append("stop").attr("offset", 0).attr("stop-color", dark);
|
|
881
|
-
left.append("stop").attr("offset", 1).attr("stop-color", "white");
|
|
882
|
-
const mid = defs.append("linearGradient").attr("id", id2);
|
|
883
|
-
mid.append("stop").attr("offset", 0).attr("stop-color", pale);
|
|
884
|
-
mid.append("stop").attr("offset", 0.5).attr("stop-color", "white");
|
|
885
|
-
mid.append("stop").attr("offset", 1).attr("stop-color", pale);
|
|
886
|
-
const right = defs.append("linearGradient").attr("id", id3);
|
|
887
|
-
right.append("stop").attr("offset", 0).attr("stop-color", "white");
|
|
888
|
-
right.append("stop").attr("offset", 1).attr("stop-color", dark);
|
|
889
|
-
tk.gradient4spanBackground = {
|
|
890
|
-
left: { id: id1, gradient: left },
|
|
891
|
-
mid: { id: id2, gradient: mid },
|
|
892
|
-
right: { id: id3, gradient: right }
|
|
893
|
-
};
|
|
894
|
-
}
|
|
895
|
-
tk.leftlabels = {
|
|
896
|
-
// all labels are rendered here, except track label
|
|
897
|
-
g: tk.gleft.append("g").attr("transform", "translate(0,17)"),
|
|
898
|
-
doms: {},
|
|
899
|
-
// keys: label name, value: label dom
|
|
900
|
-
// to avoid having to delete all labels upon tk rendering
|
|
901
|
-
laby: 0,
|
|
902
|
-
// cumulative height, 0 for no labels
|
|
903
|
-
xoff: 0,
|
|
904
|
-
maxwidth: 0
|
|
905
|
-
// set default 0 in case track runs into err, can still render tk
|
|
906
|
-
};
|
|
907
|
-
tk.leftlabels.doms.jug = makelabel(tk, block, 0);
|
|
908
|
-
{
|
|
909
|
-
const g = tk.glider.append("g");
|
|
910
|
-
tk.sections = {
|
|
911
|
-
// sections from top to bottom.
|
|
912
|
-
jug: {
|
|
913
|
-
height: 0,
|
|
914
|
-
// total height of the jug section
|
|
915
|
-
g: g.append("g"),
|
|
916
|
-
axis: g.append("g")
|
|
917
|
-
}
|
|
918
|
-
};
|
|
919
|
-
}
|
|
920
|
-
setH(tk, "axisheight", 200);
|
|
921
|
-
setH(tk, "legheight", 50);
|
|
922
|
-
setH(tk, "neckheight", 50);
|
|
923
|
-
tk._finish = loadTk_finish_closure(tk, block);
|
|
924
|
-
tk.hovertip = new Menu();
|
|
925
|
-
tk.itemtip = new Menu();
|
|
926
|
-
tk.menutip = new Menu({ padding: "" });
|
|
927
|
-
tk.load = _load(tk, block);
|
|
928
|
-
await initTermdb(tk, block);
|
|
929
|
-
if (tk.filter) await Promise.all(rehydrateFilter(tk.filter, tk.vocabApi));
|
|
930
|
-
tk.tklabel.text(tk.dslabel || tk.name);
|
|
931
|
-
tk.clear = () => {
|
|
932
|
-
tk.sections.jug.g.selectAll("*").remove();
|
|
933
|
-
};
|
|
934
|
-
tk.config_handle = block.maketkconfighandle(tk).on("click", () => {
|
|
935
|
-
configPanel(tk, block);
|
|
936
|
-
});
|
|
937
|
-
initLegend(tk, block);
|
|
938
|
-
}
|
|
939
|
-
function setH(tk, prop, v) {
|
|
940
|
-
const customv = tk[prop];
|
|
941
|
-
if (customv != void 0) {
|
|
942
|
-
if (!Number.isFinite(customv) || customv <= 0) throw new Error("invalid tk." + prop);
|
|
943
|
-
tk.sections.jug[prop] = customv;
|
|
944
|
-
delete tk[prop];
|
|
945
|
-
return;
|
|
946
|
-
}
|
|
947
|
-
tk.sections.jug[prop] = v;
|
|
948
|
-
}
|
|
949
|
-
function loadTk_finish_closure(tk, block) {
|
|
950
|
-
return (data) => {
|
|
951
|
-
tk.legend?.headTd.text(tk.dslabel + (tk.filter ? " - " + getFilterName(tk.filter) : ""));
|
|
952
|
-
if (data) {
|
|
953
|
-
if (data.error) {
|
|
954
|
-
tk.sections.jug.height = 40;
|
|
955
|
-
} else {
|
|
956
|
-
if (data.junctions?.length == 0) {
|
|
957
|
-
tk.sections.jug.g.selectAll("*").remove();
|
|
958
|
-
tk.sections.jug.axis.selectAll("*").remove();
|
|
959
|
-
tk.sections.jug.g.transition().attr("transform", "translate(0,0)");
|
|
960
|
-
tk.sections.jug.g.append("text").text("No splice junctions").attr("y", 25).attr("x", block.width / 2).attr("text-anchor", "middle").attr("dominant-baseline", "center");
|
|
961
|
-
tk.sections.jug.height = 40;
|
|
962
|
-
}
|
|
963
|
-
if (data.alert) {
|
|
964
|
-
console.log("TODO print this alert in tk", data.alert);
|
|
965
|
-
}
|
|
966
|
-
}
|
|
967
|
-
}
|
|
968
|
-
tk.height_main = tk.sections.jug.height + tk.toppad + tk.bottompad;
|
|
969
|
-
if (data) {
|
|
970
|
-
updateLegend(data, tk, block);
|
|
971
|
-
}
|
|
972
|
-
;
|
|
973
|
-
tk.leftLabelMaxwidth = tk.leftlabels.maxwidth + tk.leftlabels.xoff, block.tkcloakoff(tk, { error: data ? data.error : null });
|
|
974
|
-
block.block_setheight();
|
|
975
|
-
block.setllabel();
|
|
976
|
-
tk.callbackOnRender?.(tk, block);
|
|
977
|
-
};
|
|
978
|
-
}
|
|
979
|
-
async function initTermdb(tk, block) {
|
|
980
|
-
if (!tk.dslabel) {
|
|
981
|
-
throw new Error("tk.dslabel missing");
|
|
982
|
-
}
|
|
983
|
-
if (!tk.vocabApi) {
|
|
984
|
-
const arg = {
|
|
985
|
-
vocab: {
|
|
986
|
-
genome: block.genome.name,
|
|
987
|
-
dslabel: tk.dslabel
|
|
988
|
-
}
|
|
989
|
-
};
|
|
990
|
-
const _ = await import("./vocabulary-HCPEIO2P.js");
|
|
991
|
-
tk.vocabApi = _.vocabInit(arg);
|
|
992
|
-
if (!tk.vocabApi.app) {
|
|
993
|
-
tk.vocabApi.app = { opts: { genome: block.genome } };
|
|
994
|
-
}
|
|
995
|
-
}
|
|
996
|
-
if (!tk.termdbConfig) {
|
|
997
|
-
tk.termdbConfig = await tk.vocabApi.getTermdbConfig();
|
|
998
|
-
}
|
|
999
|
-
if (!tk.termdbConfig.queries?.junction) throw new Error("queries.junction missing");
|
|
1000
|
-
}
|
|
1001
|
-
function _load(tk, block) {
|
|
1002
|
-
return async () => {
|
|
1003
|
-
return await loadTk(tk, block);
|
|
1004
|
-
};
|
|
1005
|
-
}
|
|
1006
|
-
function configPanel(tk, block) {
|
|
1007
|
-
tk.tkconfigtip.clear().showunder(tk.config_handle.node());
|
|
1008
|
-
const holder = tk.tkconfigtip.d;
|
|
1009
|
-
{
|
|
1010
|
-
const row = holder.append("div").style("margin-bottom", "15px");
|
|
1011
|
-
row.append("span").html("Read count cutoff ");
|
|
1012
|
-
row.append("input").property("value", tk.readcountCutoff || 0).attr("type", "number").style("width", "50px").on("keyup", (event) => {
|
|
1013
|
-
if (event.code != "Enter" && event.code != "NumpadEnter") return;
|
|
1014
|
-
let v = Number(event.target.value);
|
|
1015
|
-
if (!v || v < 0) {
|
|
1016
|
-
v = 0;
|
|
1017
|
-
}
|
|
1018
|
-
if (v == 0) {
|
|
1019
|
-
if (tk.readcountCutoff) {
|
|
1020
|
-
tk.readcountCutoff = 0;
|
|
1021
|
-
loadTk(tk, block, true);
|
|
1022
|
-
} else {
|
|
1023
|
-
}
|
|
1024
|
-
return;
|
|
1025
|
-
}
|
|
1026
|
-
if (tk.readcountCutoff) {
|
|
1027
|
-
if (tk.readcountCutoff == v) {
|
|
1028
|
-
} else {
|
|
1029
|
-
tk.readcountCutoff = v;
|
|
1030
|
-
loadTk(tk, block, true);
|
|
1031
|
-
}
|
|
1032
|
-
} else {
|
|
1033
|
-
tk.readcountCutoff = v;
|
|
1034
|
-
loadTk(tk, block, true);
|
|
1035
|
-
}
|
|
1036
|
-
});
|
|
1037
|
-
row.append("div").style("font-size", ".7em").style("color", "#858585").text("For a junction, samples with read count lower than cutoff will not be shown.");
|
|
1038
|
-
}
|
|
1039
|
-
{
|
|
1040
|
-
const k = tk.sections.jug;
|
|
1041
|
-
const row = holder.append("div").style("margin-bottom", "15px");
|
|
1042
|
-
row.append("span").text("Track height");
|
|
1043
|
-
row.append("button").html(" + ").style("margin-left", "10px").on("click", () => {
|
|
1044
|
-
k.axisheight += 30;
|
|
1045
|
-
k.legheight = k.axisheight / 4;
|
|
1046
|
-
renderTk(null, tk, block);
|
|
1047
|
-
block.block_setheight();
|
|
1048
|
-
});
|
|
1049
|
-
row.append("button").html(" - ").style("margin-left", "5px").on("click", () => {
|
|
1050
|
-
if (k.axisheight <= 90) return;
|
|
1051
|
-
k.axisheight -= 30;
|
|
1052
|
-
k.legheight = k.axisheight / 4;
|
|
1053
|
-
renderTk(null, tk, block);
|
|
1054
|
-
block.block_setheight();
|
|
1055
|
-
});
|
|
1056
|
-
}
|
|
1057
|
-
{
|
|
1058
|
-
const row = holder.append("div").style("margin-bottom", "1px");
|
|
1059
|
-
const id = Math.random();
|
|
1060
|
-
const input = row.append("input").attr("type", "checkbox").style("margin-right", "10px").attr("id", id).on("change", () => {
|
|
1061
|
-
tk.yscaleUseLog = !tk.yscaleUseLog;
|
|
1062
|
-
renderTk(null, tk, block);
|
|
1063
|
-
});
|
|
1064
|
-
if (tk.yscaleUseLog) {
|
|
1065
|
-
input.property("checked", 1);
|
|
1066
|
-
}
|
|
1067
|
-
row.append("label").text("Use log10 for Y scale read count").attr("for", id);
|
|
1068
|
-
}
|
|
1069
|
-
}
|
|
1070
|
-
|
|
1071
|
-
// j2/tk.js
|
|
1072
|
-
async function loadTk(tk, block) {
|
|
1073
|
-
block.tkcloakon(tk);
|
|
1074
|
-
block.block_setheight();
|
|
1075
|
-
try {
|
|
1076
|
-
if (tk.uninitialized) {
|
|
1077
|
-
await makeTk(tk, block);
|
|
1078
|
-
delete tk.uninitialized;
|
|
1079
|
-
}
|
|
1080
|
-
const data = await getTkData(tk, block);
|
|
1081
|
-
renderTk(data, tk, block);
|
|
1082
|
-
tk._finish(data);
|
|
1083
|
-
} catch (e) {
|
|
1084
|
-
if (tk.clear) tk.clear();
|
|
1085
|
-
if (tk._finish) tk._finish({ error: e.message || e });
|
|
1086
|
-
if (e.stack) console.log(e.stack);
|
|
1087
|
-
}
|
|
1088
|
-
}
|
|
1089
|
-
function getParameter(tk, block) {
|
|
1090
|
-
const par = {
|
|
1091
|
-
genome: block.genome.name,
|
|
1092
|
-
dslabel: tk.dslabel,
|
|
1093
|
-
filter0: tk.filter0,
|
|
1094
|
-
filter: tk.filter,
|
|
1095
|
-
readcountCutoff: tk.readcountCutoff
|
|
1096
|
-
};
|
|
1097
|
-
const headers = { "Content-Type": "application/json", Accept: "application/json" };
|
|
1098
|
-
rangequery_rglst(tk, block, par);
|
|
1099
|
-
if (tk.legend?.type?.hiddenvalues?.size) par.hiddenTypes = [...tk.legend.type.hiddenvalues].join(",");
|
|
1100
|
-
return [par, headers];
|
|
1101
|
-
}
|
|
1102
|
-
async function getTkData(tk, block) {
|
|
1103
|
-
let data;
|
|
1104
|
-
if (tk.custom_data) {
|
|
1105
|
-
data = await dataFromCustomData(tk, block);
|
|
1106
|
-
} else {
|
|
1107
|
-
const [body, headers] = getParameter(tk, block);
|
|
1108
|
-
data = await dofetch3("termdb/junctions", { body, headers });
|
|
1109
|
-
}
|
|
1110
|
-
if (data.error) throw new Error(data.error);
|
|
1111
|
-
return data;
|
|
1112
|
-
}
|
|
1113
|
-
async function dataFromCustomData(tk, block) {
|
|
1114
|
-
const data = [];
|
|
1115
|
-
return data;
|
|
1116
|
-
}
|
|
1117
|
-
export {
|
|
1118
|
-
getParameter,
|
|
1119
|
-
loadTk
|
|
1120
|
-
};
|
|
1121
|
-
//# sourceMappingURL=tk-CAYWF7LX.js.map
|