@sjcrh/proteinpaint-client 2.187.0 → 2.188.1

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (963) hide show
  1. package/dist/2dmaf-6YIEXAIG.js +1372 -0
  2. package/dist/AIProjectAdmin-5K5NIQNT.js +828 -0
  3. package/dist/AppHeader-4SN5M6SZ.js +834 -0
  4. package/dist/BoxPlot-DBJA6TQF.js +1218 -0
  5. package/dist/CorrelationVolcano-MDMTMTT5.js +618 -0
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  848. /package/dist/{leftlabel.sample-ZBI4NHCV.js.map → leftlabel.sample-JU7AIPZL.js.map} +0 -0
  849. /package/dist/{legacyDataset-PBCPC5I7.js.map → legacyDataset-TT4CHF23.js.map} +0 -0
  850. /package/dist/{lollipop-K7S6ASFE.js.map → lollipop-JG74M6PJ.js.map} +0 -0
  851. /package/dist/{maf-JEW6PPJB.js.map → maf-PDL2EGHI.js.map} +0 -0
  852. /package/dist/{maftimeline-7URL27MC.js.map → maftimeline-V43NQEEE.js.map} +0 -0
  853. /package/dist/{matrix-6EK5WGIG.js.map → matrix-EB2EFP4S.js.map} +0 -0
  854. /package/dist/{matrix-DKBD5RIL.js.map → matrix-Q57FU5FE.js.map} +0 -0
  855. /package/dist/{matrix.cells-KEIOXJQ7.js.map → matrix.cells-NJIMPD32.js.map} +0 -0
  856. /package/dist/{matrix.config-FGJB4VVM.js.map → matrix.config-GLDEQD3H.js.map} +0 -0
  857. /package/dist/{matrix.data-QGCGFLD7.js.map → matrix.data-6SHAKOQU.js.map} +0 -0
  858. /package/dist/{matrix.groups-HBPLZ2QX.js.map → matrix.groups-MTDEANQA.js.map} +0 -0
  859. /package/dist/{matrix.integration.spec-R4PF67KF.js.map → matrix.integration.spec-JCZ5VQJU.js.map} +0 -0
  860. /package/dist/{matrix.interactivity-M3SY33ET.js.map → matrix.interactivity-SVRNWL6V.js.map} +0 -0
  861. /package/dist/{matrix.layout-H6WQ3ZMW.js.map → matrix.layout-2HREO42N.js.map} +0 -0
  862. /package/dist/{matrix.legend-UCL7HM26.js.map → matrix.legend-QHVKT3MP.js.map} +0 -0
  863. /package/dist/{matrix.renderers-3PPFSS7Z.js.map → matrix.renderers-IYR3ZY6V.js.map} +0 -0
  864. /package/dist/{matrix.serieses-S2TJ3E6P.js.map → matrix.serieses-2VMTQXL2.js.map} +0 -0
  865. /package/dist/{matrix.sort-CFA4UWBJ.js.map → matrix.sort-PWA2RQQR.js.map} +0 -0
  866. /package/dist/{matrix.sort.unit.spec-562VIWDS.js.map → matrix.sort.unit.spec-3OYIPTFY.js.map} +0 -0
  867. /package/dist/{matrix.sorterUi-FT7K5664.js.map → matrix.sorterUi-Y5QLO75X.js.map} +0 -0
  868. /package/dist/{matrix.sorterUi.unit.spec-GAHHUN3K.js.map → matrix.sorterUi.unit.spec-BNEXQHLP.js.map} +0 -0
  869. /package/dist/{mavb-HPW5X55U.js.map → mavb-IZDDU4KK.js.map} +0 -0
  870. /package/dist/{mds.fimo-HSBKLIOX.js.map → mds.fimo-FWBL7JE6.js.map} +0 -0
  871. /package/dist/{mds.samplescatterplot-DE27OMJE.js.map → mds.samplescatterplot-T47C7DJB.js.map} +0 -0
  872. /package/dist/{mds.survivalplot-IW22UGCE.js.map → mds.survivalplot-MFZJCGS6.js.map} +0 -0
  873. /package/dist/{numericDictTermCluster-DOD66G3A.js.map → numericDictTermCluster-I2W67RGA.js.map} +0 -0
  874. /package/dist/{oncomatrix-BZCVCPR4.js.map → oncomatrix-6W7IBAED.js.map} +0 -0
  875. /package/dist/{oncomatrix.spec-IHYCIAP4.js.map → oncomatrix.spec-CEFH5IGH.js.map} +0 -0
  876. /package/dist/{plot.2dvaf-QLOZ54VC.js.map → plot.2dvaf-BN6CFLNU.js.map} +0 -0
  877. /package/dist/{plot.app-XDVDR23J.js.map → plot.app-7EYWUCZV.js.map} +0 -0
  878. /package/dist/{plot.barplot-XOESF7OQ.js.map → plot.barplot-MDIARSQD.js.map} +0 -0
  879. /package/dist/{plot.boxplot-VNOC2CHT.js.map → plot.boxplot-RUHGXC54.js.map} +0 -0
  880. /package/dist/{plot.brainImaging-7ZEOY4UR.js.map → plot.brainImaging-JEE32ZBV.js.map} +0 -0
  881. /package/dist/{plot.disco-6GVDYK7A.js.map → plot.disco-2RPNPX6E.js.map} +0 -0
  882. /package/dist/{plot.dzi-TEFPPPL6.js.map → plot.dzi-7VTYYGGW.js.map} +0 -0
  883. /package/dist/{plot.ssgq-OG4TODLO.js.map → plot.ssgq-FHE5KU5C.js.map} +0 -0
  884. /package/dist/{plot.vaf2cov-VMZRJULA.js.map → plot.vaf2cov-WDJJM5Q4.js.map} +0 -0
  885. /package/dist/{plot.wsi-2CHZZ7AC.js.map → plot.wsi-FQZWHNSF.js.map} +0 -0
  886. /package/dist/{polar-QUYQRQOQ.js.map → polar-M7EGINN4.js.map} +0 -0
  887. /package/dist/{polar2-OXXLAXJC.js.map → polar2-JFYY43K2.js.map} +0 -0
  888. /package/dist/{profile.spec-TI6PRHNJ.js.map → profile.spec-SIOHASOX.js.map} +0 -0
  889. /package/dist/{profileBarchart-GEK77XEB.js.map → profileBarchart-6JLEKVJV.js.map} +0 -0
  890. /package/dist/{profileForms-NR3VNHKM.js.map → profileForms-G6CH73RV.js.map} +0 -0
  891. /package/dist/{profilePlot-GGKO3IW5.js.map → profilePlot-NQYJOBVV.js.map} +0 -0
  892. /package/dist/{profileRadar-MN3LX5ER.js.map → profileRadar-4TNWIXDB.js.map} +0 -0
  893. /package/dist/{profileRadarFacility-3G2HWB2L.js.map → profileRadarFacility-XPH3LCBQ.js.map} +0 -0
  894. /package/dist/{proteomeAbundance-O4BB55O3.js.map → proteomeAbundance-NQ4635NL.js.map} +0 -0
  895. /package/dist/{qualitative-Q3TT73O7.js.map → qualitative-DL4WJG3O.js.map} +0 -0
  896. /package/dist/{radar2-LSD3VPZT.js.map → radar2-YNOQWHBT.js.map} +0 -0
  897. /package/dist/{radarFacility2-LZGIXY7A.js.map → radarFacility2-24UPSI7S.js.map} +0 -0
  898. /package/dist/{regression-J3XDAPAZ.js.map → regression-URAUTLTD.js.map} +0 -0
  899. /package/dist/{regression.inputs-BBZYI5OI.js.map → regression.inputs-UDVOU7FB.js.map} +0 -0
  900. /package/dist/{regression.inputs.term-7BW6XGLG.js.map → regression.inputs.term-BWW6W34R.js.map} +0 -0
  901. /package/dist/{regression.inputs.values.table-DYX2YU4H.js.map → regression.inputs.values.table-UKGIZTXG.js.map} +0 -0
  902. /package/dist/{regression.integration.spec-WLXZYKWW.js.map → regression.integration.spec-EBHQTNA3.js.map} +0 -0
  903. /package/dist/{regression.results-K5Q2N2KW.js.map → regression.results-XTOSWIP6.js.map} +0 -0
  904. /package/dist/{regression.spec-VT7T6KBY.js.map → regression.spec-KG2I53VR.js.map} +0 -0
  905. /package/dist/{report-3D3L573D.js.map → report-KH7SNPVF.js.map} +0 -0
  906. /package/dist/{sampleScatter.spec-6IPJQLM2.js.map → sampleScatter.spec-PIXGS3LG.js.map} +0 -0
  907. /package/dist/{sampleView-5JMFI4HF.js.map → sampleView-TWS6VT55.js.map} +0 -0
  908. /package/dist/{samplelst-SUCB5WOZ.js.map → samplelst-6AB5Y4WR.js.map} +0 -0
  909. /package/dist/{samplematrix-A5SZBKO6.js.map → samplematrix-AJAF555E.js.map} +0 -0
  910. /package/dist/{sc-NAA6ESO6.js.map → sc-PMNYZKXA.js.map} +0 -0
  911. /package/dist/{scatter-EQCN2HYE.js.map → scatter-Q2GH3ZJD.js.map} +0 -0
  912. /package/dist/{scatter.integration.spec-7NXIYS67.js.map → scatter.integration.spec-SMMYKWH3.js.map} +0 -0
  913. /package/dist/{selectGenomeWithTklst-KXODNCY6.js.map → selectGenomeWithTklst-VE4SDYY7.js.map} +0 -0
  914. /package/dist/{singleCellCellType-HMIW76YB.js.map → singleCellCellType-S324GCKW.js.map} +0 -0
  915. /package/dist/{singleCellCellType.unit.spec-ZCZET56X.js.map → singleCellCellType.unit.spec-NXC2GELH.js.map} +0 -0
  916. /package/dist/{singleCellGeneExpression-IUCUHF6R.js.map → singleCellGeneExpression-6H4HRKIA.js.map} +0 -0
  917. /package/dist/{singleCellGeneExpression.unit.spec-J4D6F2N3.js.map → singleCellGeneExpression.unit.spec-HIJXVUWJ.js.map} +0 -0
  918. /package/dist/{singleCellPlot-L6W3MDGG.js.map → singleCellPlot-H7PCZ2DP.js.map} +0 -0
  919. /package/dist/{singlecell-A6ECAAPI.js.map → singlecell-4LH3MQVL.js.map} +0 -0
  920. /package/dist/{singlecell-KBABNXC5.js.map → singlecell-MOSYT3RI.js.map} +0 -0
  921. /package/dist/{snp-RO7ATG6E.js.map → snp-IKLGTD4Q.js.map} +0 -0
  922. /package/dist/{snp.unit.spec-ZJLRGJD4.js.map → snp.unit.spec-GC74MUVM.js.map} +0 -0
  923. /package/dist/{snplocus-N3CU6NRP.js.map → snplocus-RIABFSBQ.js.map} +0 -0
  924. /package/dist/{spliceevent.a53ss.diagram-7PHT4COB.js.map → spliceevent.a53ss.diagram-4E2IYYHL.js.map} +0 -0
  925. /package/dist/{spliceevent.exonskip.diagram-3CZTY6QD.js.map → spliceevent.exonskip.diagram-C56R6XLQ.js.map} +0 -0
  926. /package/dist/{spliceevent.noeventdiagram-GQE256DT.js.map → spliceevent.noeventdiagram-SIPMAKXI.js.map} +0 -0
  927. /package/dist/{ssGSEA-4I3L5MX2.js.map → ssGSEA-5QNHLSOI.js.map} +0 -0
  928. /package/dist/{ssGSEA.unit.spec-PZCC5YU7.js.map → ssGSEA.unit.spec-KVPN553B.js.map} +0 -0
  929. /package/dist/{summarizeCnvGeneexp-ASXUQW56.js.map → summarizeCnvGeneexp-K4VGJSW6.js.map} +0 -0
  930. /package/dist/{summarizeGeneexpSurvival-ULGUOW5V.js.map → summarizeGeneexpSurvival-HGHX65FN.js.map} +0 -0
  931. /package/dist/{summarizeMutationCnv-VDUCIUGM.js.map → summarizeMutationCnv-3K4Z6R2X.js.map} +0 -0
  932. /package/dist/{summarizeMutationDiagnosis-FMAAMCZC.js.map → summarizeMutationDiagnosis-M2MHUPRT.js.map} +0 -0
  933. /package/dist/{summarizeMutationSurvival-GZ4NGDJT.js.map → summarizeMutationSurvival-WVBUP3GA.js.map} +0 -0
  934. /package/dist/{summary-2WNZ6JSB.js.map → summary-RZHZXCU5.js.map} +0 -0
  935. /package/dist/{summary.integration.spec-XPMYB6GM.js.map → summary.integration.spec-FGZP7DY7.js.map} +0 -0
  936. /package/dist/{summaryInput-2UGXEA5C.js.map → summaryInput-UGM7MMCR.js.map} +0 -0
  937. /package/dist/{sunburst-76WCQLTT.js.map → sunburst-L27U7LV7.js.map} +0 -0
  938. /package/dist/{survival-3EAMPHSX.js.map → survival-5ZMEBV6O.js.map} +0 -0
  939. /package/dist/{survival-23IZM4ML.js.map → survival-JWRRGTJT.js.map} +0 -0
  940. /package/dist/{survival.integration.spec-YNVAKBV3.js.map → survival.integration.spec-Z5542I4V.js.map} +0 -0
  941. /package/dist/{svgraph-G2M5LXEP.js.map → svgraph-O6ZVLNNN.js.map} +0 -0
  942. /package/dist/{svmr-BUDBVU34.js.map → svmr-ULFV7OSH.js.map} +0 -0
  943. /package/dist/{table-QJSZ6YFK.js.map → table-CHRQH2GH.js.map} +0 -0
  944. /package/dist/{termCollection-2YAY3RLZ.js.map → termCollection-FAO6ZA6F.js.map} +0 -0
  945. /package/dist/{termCollection-MAMDMEDD.js.map → termCollection-GBXS3GOY.js.map} +0 -0
  946. /package/dist/{termCollection.unit.spec-UY7G2BHG.js.map → termCollection.unit.spec-4WRTOV6E.js.map} +0 -0
  947. /package/dist/{tk-GFGP3F76.js.map → tk-KNUBWRNK.js.map} +0 -0
  948. /package/dist/{tp.ui-OQ757UIE.js.map → tp.ui-2PPYOQYL.js.map} +0 -0
  949. /package/dist/{tvs.density-BJK23JYJ.js.map → tvs.density-BZ5SKDQS.js.map} +0 -0
  950. /package/dist/{tvs.dt-TOYEFKNT.js.map → tvs.dt-TDNSTGQR.js.map} +0 -0
  951. /package/dist/{tvs.dtcnv.categorical-EO2VLFL2.js.map → tvs.dtcnv.categorical-P2IGIE4I.js.map} +0 -0
  952. /package/dist/{tvs.dtcnv.continuous-ZAHTKZ4Y.js.map → tvs.dtcnv.continuous-2XUCRBDR.js.map} +0 -0
  953. /package/dist/{tvs.dtfusion-BY3AHBL3.js.map → tvs.dtfusion-PRHZVMOG.js.map} +0 -0
  954. /package/dist/{tvs.dtsnvindel-UM5LQ4FR.js.map → tvs.dtsnvindel-KGKBW5JS.js.map} +0 -0
  955. /package/dist/{tvs.dtsv-H7ZVHLS5.js.map → tvs.dtsv-M3CY5TZF.js.map} +0 -0
  956. /package/dist/{tvs.numeric-66FP6RRH.js.map → tvs.numeric-W74JCC5P.js.map} +0 -0
  957. /package/dist/{tvs.samplelst-Q5ECTZOY.js.map → tvs.samplelst-BTWFBBAN.js.map} +0 -0
  958. /package/dist/{tvs.termCollection-FYNMKZTR.js.map → tvs.termCollection-Y64QIKOA.js.map} +0 -0
  959. /package/dist/{violin-EGWLAJVM.js.map → violin-3LLHHV3L.js.map} +0 -0
  960. /package/dist/{violin.integration.spec-3P4TYHBR.js.map → violin.integration.spec-6NF5FDLQ.js.map} +0 -0
  961. /package/dist/{violin.interactivity-VWDR4LYB.js.map → violin.interactivity-W2AKZ24D.js.map} +0 -0
  962. /package/dist/{violin.renderer-WWTU6J7X.js.map → violin.renderer-CRFYYZRI.js.map} +0 -0
  963. /package/dist/{vocabulary-JG4ZITOH.js.map → vocabulary-AUJOAVYS.js.map} +0 -0
@@ -1,2249 +0,0 @@
1
- import {
2
- blocklazyload
3
- } from "./chunk-64Z22QAH.js";
4
- import {
5
- hicParseFile
6
- } from "./chunk-RSE2FOKW.js";
7
- import {
8
- AppBase,
9
- ColorScale,
10
- axisstyle,
11
- first_genetrack_tolist,
12
- font,
13
- newpane,
14
- showErrorsWithCounter,
15
- tkt
16
- } from "./chunk-LN3QYBGI.js";
17
- import "./chunk-HJ6L54YS.js";
18
- import "./chunk-LSEFWW72.js";
19
- import "./chunk-BTJFVY3R.js";
20
- import {
21
- Menu
22
- } from "./chunk-HYOEWQ5P.js";
23
- import "./chunk-HBW42TDT.js";
24
- import "./chunk-G6O3URDN.js";
25
- import "./chunk-FN5XPUPH.js";
26
- import "./chunk-KWM6B3NL.js";
27
- import "./chunk-UCLS2SVB.js";
28
- import "./chunk-UWYCEYML.js";
29
- import "./chunk-7UHUOC6F.js";
30
- import {
31
- dofetch3
32
- } from "./chunk-YC6ZJ7RP.js";
33
- import {
34
- StoreBase,
35
- getAppInit,
36
- getCompInit,
37
- getStoreInit
38
- } from "./chunk-MVTCBVSX.js";
39
- import "./chunk-2K5DSRBJ.js";
40
- import "./chunk-ZYY54HBU.js";
41
- import "./chunk-EGWVYY7K.js";
42
- import {
43
- bplen
44
- } from "./chunk-AMYSEKPF.js";
45
- import "./chunk-AQVOYTLS.js";
46
- import "./chunk-TV74I3Y5.js";
47
- import "./chunk-KSGA62R2.js";
48
- import {
49
- axisBottom,
50
- axisRight
51
- } from "./chunk-LOZEKOES.js";
52
- import "./chunk-TOU7EVFQ.js";
53
- import {
54
- format,
55
- linear
56
- } from "./chunk-OAWQ6LOO.js";
57
- import "./chunk-L4QG7XZE.js";
58
- import "./chunk-KYBIQBXE.js";
59
- import {
60
- pointer_default,
61
- select_default
62
- } from "./chunk-I6Y4O3RR.js";
63
- import "./chunk-OMR2DT66.js";
64
- import "./chunk-DQC5FFGV.js";
65
- import "./chunk-HFNDKYVF.js";
66
-
67
- // tracks/hic/HicStore.ts
68
- var HicStore = class _HicStore extends StoreBase {
69
- constructor(opts) {
70
- super(opts);
71
- this.views = ["genome", "chrpair", "detail", "horizontal"];
72
- this.type = _HicStore.type;
73
- this.defaultState = {
74
- defaultNmeth: "NONE",
75
- loading: true,
76
- minBinNum_bp: 200,
77
- minFragSpan: 200,
78
- initialBinNum: 20,
79
- settings: {
80
- widthHeightPx: 800
81
- }
82
- };
83
- }
84
- static {
85
- this.type = "store";
86
- }
87
- init() {
88
- this.state = Object.assign({}, this.defaultState, this.state);
89
- }
90
- };
91
- var hicStoreInit = getStoreInit(HicStore);
92
- HicStore.prototype.actions = {
93
- view_create(action) {
94
- if (!action.view) throw Error("view_create: missing view");
95
- if (!this.views.some((v) => v == action.view)) throw Error(`view_create: unknown view = ${action.view}`);
96
- this.state.currView = action.view;
97
- const opts = Object.assign(this.state, action.config);
98
- this.state = opts;
99
- },
100
- view_update(action) {
101
- if (action.view) {
102
- if (!this.views.some((v) => v == action.view)) throw Error(`view_update: unknown view = ${action.view}`);
103
- const opts = Object.assign(this.state[action.view], action.config);
104
- this.state[action.view] = opts;
105
- } else {
106
- const opts = Object.assign(this.state, action.config);
107
- this.state = opts;
108
- }
109
- },
110
- loading_active(action) {
111
- this.state.loading = action.active;
112
- }
113
- };
114
-
115
- // tracks/hic/dom/LoadingOverlay.ts
116
- var LoadingOverlay = class _LoadingOverlay {
117
- constructor(opts) {
118
- this.hasStatePreMain = true;
119
- this.type = _LoadingOverlay.type;
120
- this.app = opts.app;
121
- this.loadingDiv = opts.loadingDiv;
122
- }
123
- static {
124
- this.type = "loadingOverlay";
125
- }
126
- reactsTo(action) {
127
- if (action.type.startsWith("loading")) return true;
128
- else return false;
129
- }
130
- getState(appState) {
131
- return appState;
132
- }
133
- init() {
134
- this.loadingDiv.append("div").attr("class", "sjpp-spinner").style("display", "");
135
- }
136
- main(appState) {
137
- const loading = this.app.getState(appState).loading;
138
- this.loadingDiv.style("display", loading ? "" : "none");
139
- }
140
- };
141
- var loadingInit = getCompInit(LoadingOverlay);
142
-
143
- // tracks/hic/dom/ColorizeElement.ts
144
- var ColorizeElement = class {
145
- colorizeElement(xCoord, yCoord, v, obj, width, height, bpMinV, bpMaxV, currView) {
146
- if (v >= 0) {
147
- const p = v >= bpMaxV ? 0 : v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV - v) / bpMaxV);
148
- const positiveFill = `rgb(255, ${p}, ${p})`;
149
- if (currView === "genome") {
150
- obj.ctx.fillStyle = positiveFill;
151
- obj.ctx2.fillStyle = positiveFill;
152
- } else {
153
- obj.fillStyle = positiveFill;
154
- }
155
- } else {
156
- const p = v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV + v) / bpMaxV);
157
- const negativeFill = `rgb(${p}, ${p}, 255)`;
158
- if (currView === "genome") {
159
- obj.ctx.fillStyle = negativeFill;
160
- obj.ctx2.fillStyle = negativeFill;
161
- } else {
162
- obj.fillStyle = negativeFill;
163
- }
164
- }
165
- if (currView === "genome") {
166
- obj.ctx.fillRect(yCoord, xCoord, width, height);
167
- obj.ctx2.fillRect(xCoord, yCoord, width, height);
168
- } else {
169
- obj.fillRect(xCoord, yCoord, width, height);
170
- }
171
- }
172
- };
173
-
174
- // tracks/hic/data/Resolution.ts
175
- var Resolution = class {
176
- constructor(error) {
177
- this.error = error;
178
- }
179
- getResolution(state, hic) {
180
- if (state.currView == "genome") return hic["bpresolution"][0];
181
- if (state.currView == "chrpair") {
182
- const resolution = this.getChrPairResolution(hic, state.x, state.y, state.minBinNum_bp);
183
- return resolution;
184
- } else if (state.currView == "detail") {
185
- const maxBpWidth = Math.max(state.x.stop - state.x.start, state.y.stop - state.y.start);
186
- let resolution = this.findResFromArray(maxBpWidth, state.minBinNum_bp, hic.bpresolution);
187
- if (resolution == null && !hic.enzyme) {
188
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
189
- }
190
- return resolution;
191
- } else {
192
- this.error(`Unknown view: ${state.currView}`);
193
- throw `Unknown view: ${state.currView}`;
194
- }
195
- }
196
- getChrPairResolution(hic, x, y, minBinNum_bp) {
197
- const chrxlen = hic.genome.chrlookup[x.chr.toUpperCase()].len;
198
- const chrylen = hic.genome.chrlookup[y.chr.toUpperCase()].len;
199
- const maxchrlen = Math.max(chrxlen, chrylen);
200
- const resolution = this.findResFromArray(maxchrlen, minBinNum_bp, hic.bpresolution);
201
- if (resolution == null) {
202
- this.error(`No suitable resolution for ${x.chr}-${y.chr} pair.`);
203
- return;
204
- }
205
- return resolution;
206
- }
207
- findResFromArray(max, defaultValue, resolutionArray, returnNum) {
208
- let resolution = null;
209
- for (const res of resolutionArray) {
210
- if (max / res > defaultValue) {
211
- resolution = res;
212
- break;
213
- }
214
- }
215
- if (returnNum && resolution == null) {
216
- resolution = resolutionArray[resolutionArray.length - 1];
217
- }
218
- return resolution;
219
- }
220
- getDefaultViewSpan(hic, x, y, initialBinNum, minBinNum_bp) {
221
- const chrpairResolution = this.getChrPairResolution(hic, x, y, minBinNum_bp);
222
- if (!chrpairResolution) return;
223
- return chrpairResolution * initialBinNum;
224
- }
225
- };
226
-
227
- // tracks/hic/data/Positions.ts
228
- var Positions = class {
229
- constructor(error, minBinNum_bp) {
230
- this.error = error;
231
- this.resolution = new Resolution(this.error);
232
- this.minBinNum_bp = minBinNum_bp;
233
- }
234
- /**
235
- *
236
- * @param x x coordinate of pointer
237
- * @param y y coordinate of pointer
238
- * @param binpx
239
- * @param chrx x chr from state
240
- * @param chry y chr from state
241
- * @param hic
242
- * @param initialBinNum Set in the state
243
- * @returns
244
- */
245
- setPosition(x, y, binpx, chrx, chry, hic, initialBinNum) {
246
- const resolution = this.resolution.getChrPairResolution(hic, chrx, chry, this.minBinNum_bp);
247
- const viewrangebpw = resolution * initialBinNum;
248
- let coordx = Math.max(1, Math.floor(x * resolution / binpx) - viewrangebpw / 2);
249
- let coordy = Math.max(1, Math.floor(y * resolution / binpx) - viewrangebpw / 2);
250
- {
251
- const lenx = hic.genome.chrlookup[chrx.chr.toUpperCase()].len;
252
- if (coordx + viewrangebpw >= lenx) {
253
- coordx = lenx - viewrangebpw;
254
- }
255
- const leny = hic.genome.chrlookup[chry.chr.toUpperCase()].len;
256
- if (coordy + viewrangebpw > leny) {
257
- coordy = leny - viewrangebpw;
258
- }
259
- }
260
- const xObj = {
261
- chr: chrx.chr,
262
- start: coordx,
263
- stop: coordx + viewrangebpw
264
- };
265
- const yObj = {
266
- chr: chry.chr,
267
- start: coordy,
268
- stop: coordy + viewrangebpw
269
- };
270
- return [xObj, yObj];
271
- }
272
- };
273
-
274
- // tracks/hic/data/GridElementsFormattedData.ts
275
- var GridElementsFormattedData = class {
276
- /**
277
- * Format the data for the grid elements.
278
- * @param items The data to format.
279
- * @param binpx The bin size in pixels.
280
- * @param resolution The resolution.
281
- * @param isFirstChrX Whether the first chromosome is X. Used for chrpair view.
282
- * @param isIntraChr Whether the data is intra-chromosomal. Used for chrpair view
283
- * @returns The formatted data.
284
- */
285
- formatData(view, items, binpx, resolution, isFirstChrX, isIntraChr) {
286
- const formattedData = [];
287
- for (const [xCoord, yCoord, value] of items) {
288
- const xPx = Math.floor(xCoord / resolution) * binpx;
289
- const yPx = Math.floor(yCoord / resolution) * binpx;
290
- if (view == "genome") {
291
- formattedData.push([xPx, yPx, value]);
292
- }
293
- if (view == "chrpair") {
294
- const x = isFirstChrX ? xPx : yPx;
295
- const y = isFirstChrX ? yPx : xPx;
296
- formattedData.push([x, y, value]);
297
- if (isIntraChr) {
298
- formattedData.push([y, x, value]);
299
- }
300
- }
301
- }
302
- return formattedData;
303
- }
304
- };
305
-
306
- // tracks/hic/data/FirstChrX.ts
307
- var FirstChrX = class {
308
- constructor(chrorder, chrx, chry) {
309
- this.chrorder = chrorder;
310
- this.chrx = chrx;
311
- this.chry = chry;
312
- }
313
- isFirstX() {
314
- if (this.chrx == this.chry) return true;
315
- return this.chrorder.indexOf(this.chrx) < this.chrorder.indexOf(this.chry);
316
- }
317
- };
318
-
319
- // tracks/hic/chrpair/ChrPairView.ts
320
- var ChrPairView = class {
321
- constructor(opts) {
322
- this.binpx = 1;
323
- /** padding on the ends of x/y chr coordinate axes */
324
- this.axispad = 10;
325
- this.axisLabelFontSize = 15;
326
- this.calcResolution = null;
327
- this.data = [];
328
- this.app = opts.app;
329
- this.hic = opts.hic;
330
- this.plotDiv = opts.plotDiv;
331
- this.items = opts.items;
332
- this.parent = opts.parent;
333
- this.chrxlen = this.hic.genome.chrlookup[this.parent("state").x.chr.toUpperCase()].len;
334
- this.chrylen = this.hic.genome.chrlookup[this.parent("state").y.chr.toUpperCase()].len;
335
- this.maxchrlen = Math.max(this.chrxlen, this.chrylen);
336
- this.colorizeElement = new ColorizeElement();
337
- this.positions = new Positions(opts.error, this.parent("state").minBinNum_bp);
338
- this.formattedData = new GridElementsFormattedData();
339
- }
340
- setDefaultBinpx() {
341
- if (this.calcResolution == null) return;
342
- while (this.binpx * this.maxchrlen / this.calcResolution < 600) {
343
- this.binpx++;
344
- }
345
- }
346
- renderAxes() {
347
- if (this.calcResolution == null) return;
348
- const svgY = this.plotDiv.yAxis.append("svg");
349
- const h = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
350
- svgY.attr("width", 100).attr("height", this.axispad * 2 + h);
351
- svgY.append("g").attr("data-testid", "sjpp-chrpair-svg-y").attr("transform", "translate(80," + (this.axispad + h / 2) + ")").append("text").text(this.parent("state").y.chr).attr("text-anchor", "middle").attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("dominant-baseline", "central").attr("transform", "rotate(90)");
352
- axisstyle({
353
- axis: svgY.append("g").attr("transform", `translate(1, ${this.axispad})`).call(axisRight(linear().domain([0, this.chrylen]).range([0, h])).tickFormat(format(".2s"))),
354
- showline: true
355
- });
356
- const svgX = this.plotDiv.xAxis.append("svg").style("margin-top", "-4px");
357
- const w = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
358
- svgX.attr("height", 100).attr("width", this.axispad * 2 + w);
359
- svgX.append("text").attr("data-testid", "sjpp-chrpair-svg-x").text(this.parent("state").x.chr).attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("x", this.axispad + w / 2).attr("text-anchor", "middle").attr("y", 60);
360
- axisstyle({
361
- axis: svgX.append("g").attr("transform", "translate(" + this.axispad + ",1)").call(axisBottom(linear().domain([0, this.chrxlen]).range([0, w])).tickFormat(format(".2s"))),
362
- showline: true
363
- });
364
- }
365
- renderCanvas() {
366
- const initDetailView = this.initDetailView.bind(this);
367
- this.canvas = this.plotDiv.plot.append("canvas").attr("data-testid", "sjpp-chrpair-canvas").style("margin", this.axispad + "px").on("click", async function(event) {
368
- const [x, y] = pointer_default(event, this);
369
- initDetailView(x, y);
370
- }).node();
371
- this.canvas.width = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
372
- this.canvas.height = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
373
- this.ctx = this.canvas.getContext("2d");
374
- }
375
- initDetailView(x, y) {
376
- const [xObj, yObj] = this.positions.setPosition(
377
- x,
378
- y,
379
- this.binpx,
380
- this.parent("state").x,
381
- this.parent("state").y,
382
- this.hic,
383
- this.parent("state").initialBinNum
384
- );
385
- this.app.dispatch({
386
- type: "view_create",
387
- view: "detail",
388
- config: {
389
- x: xObj,
390
- y: yObj
391
- }
392
- });
393
- }
394
- render() {
395
- this.calcResolution = this.parent("calcResolution");
396
- this.setDefaultBinpx();
397
- this.renderAxes();
398
- this.renderCanvas();
399
- this.update(this.items);
400
- }
401
- update(items) {
402
- this.items = items;
403
- const firstisx = new FirstChrX(this.hic.chrorder, this.parent("state").x.chr, this.parent("state").y.chr).isFirstX();
404
- const isintrachr = this.parent("state").x.chr === this.parent("state").y.chr;
405
- this.data = this.formattedData.formatData(
406
- "chrpair",
407
- items.items,
408
- this.binpx,
409
- this.calcResolution,
410
- firstisx,
411
- isintrachr
412
- );
413
- this.ctx.clearRect(0, 0, this.canvas.width, this.canvas.height);
414
- for (const [x, y, v] of this.data) {
415
- this.colorizeElement.colorizeElement(
416
- x,
417
- y,
418
- v,
419
- this.ctx,
420
- this.binpx,
421
- //width
422
- this.binpx,
423
- //height
424
- this.parent("min"),
425
- this.parent("max"),
426
- "chrpair"
427
- );
428
- }
429
- this.app.dispatch({ type: "loading_active", active: false });
430
- }
431
- };
432
-
433
- // tracks/hic/horizontal/HorizontalView.ts
434
- var HorizontalView = class {
435
- constructor(opts) {
436
- /** Defaults*/
437
- this.maxPercentage = 5;
438
- this.subPanelPxWidth = 600;
439
- this.borderColor = "rgba(200,0,0,.1)";
440
- this.app = opts.app;
441
- this.hic = opts.hic;
442
- this.plotDiv = opts.plotDiv;
443
- this.items = opts.items;
444
- this.parent = opts.parent;
445
- }
446
- setRunPpTracks() {
447
- const tracks = [
448
- {
449
- type: "hicstraw",
450
- file: this.hic.file,
451
- url: this.hic.url,
452
- name: this.hic.name,
453
- enzyme: this.hic.enzyme,
454
- maxpercentage: this.maxPercentage,
455
- pyramindup: 1
456
- }
457
- ];
458
- if (this.hic.tklst) {
459
- for (const t of this.hic.tklst) {
460
- tracks.push(t);
461
- }
462
- }
463
- first_genetrack_tolist(this.hic.genome, tracks);
464
- return tracks;
465
- }
466
- setRunPpArgs(tracks) {
467
- const arg = {
468
- holder: this.plotDiv.plot,
469
- hostURL: this.hic.hostURL,
470
- jwt: this.hic.jwt,
471
- genome: this.hic.genome,
472
- nobox: 1,
473
- tklst: tracks
474
- };
475
- const state = this.parent("state");
476
- if (state.x.chr == state.y.chr && Math.max(state.x.start, state.y.start) < Math.min(state.x.stop, state.y.stop)) {
477
- arg["chr"] = state.x.chr;
478
- arg["start"] = Math.min(state.x.start, state.y.start);
479
- arg["stop"] = Math.max(state.x.stop, state.y.stop);
480
- } else {
481
- arg["chr"] = state.x.chr;
482
- arg["start"] = state.x.start;
483
- arg["stop"] = state.x.stop;
484
- arg["width"] = this.subPanelPxWidth;
485
- arg["subpanels"] = [
486
- {
487
- chr: state.y.chr,
488
- start: state.y.start,
489
- stop: state.y.stop,
490
- width: this.subPanelPxWidth,
491
- leftpad: 10,
492
- leftborder: this.borderColor
493
- }
494
- ];
495
- }
496
- return arg;
497
- }
498
- render() {
499
- const tracks = this.setRunPpTracks();
500
- const arg = this.setRunPpArgs(tracks);
501
- blocklazyload(arg);
502
- }
503
- // update() {
504
- // //Not required.
505
- // //If controls are added back. Implement changes here.
506
- // }
507
- };
508
-
509
- // tracks/hic/detail/DetailBlock.ts
510
- var DetailBlock = class {
511
- constructor(app, hic, blockwidth, bbmargin, holder, isYblock) {
512
- /** Defaults */
513
- this.leftheadw = 20;
514
- this.rightheadw = 40;
515
- this.lpad = 1;
516
- this.rpad = 1;
517
- this.firstRender = true;
518
- this.app = app;
519
- this.hic = hic;
520
- this.width = blockwidth;
521
- this.bbmargin = bbmargin;
522
- this.holder = holder;
523
- this.isYblock = isYblock;
524
- this.bbw = this.leftheadw + this.lpad + this.width + this.rpad + this.rightheadw + 2 * this.bbmargin;
525
- this.defaultLeft = this.bbmargin + this.leftheadw + this.lpad;
526
- this.defaultTop = this.bbmargin + this.rightheadw + this.rpad;
527
- }
528
- setArgs(chrObj) {
529
- const runPpArgs = {
530
- hostURL: this.hic.hostURL,
531
- genome: this.hic.genome,
532
- holder: this.holder,
533
- noresize: true,
534
- nobox: true,
535
- butrowbottom: true,
536
- style: {
537
- margin: `${this.bbmargin}px`
538
- },
539
- width: this.width,
540
- leftheadw: this.leftheadw,
541
- chr: chrObj.chr,
542
- start: chrObj.start,
543
- stop: chrObj.stop,
544
- rightheadw: this.rightheadw,
545
- tklst: [],
546
- rotated: this.isYblock,
547
- showreverse: this.isYblock
548
- };
549
- first_genetrack_tolist(this.hic.genome, runPpArgs.tklst);
550
- return runPpArgs;
551
- }
552
- setMethods(canvasHolder, canvas, sheath) {
553
- const runPpMethods = {
554
- onloadalltk_always: () => {
555
- this.onload(canvasHolder, canvas, sheath);
556
- },
557
- onpanning: (xoff) => this.onpanning(xoff, canvas)
558
- };
559
- if (this.isYblock) {
560
- runPpMethods["onsetheight"] = (bbh) => {
561
- this.holder.transition().style("left", `${bbh + this.bbmargin + 30}px`);
562
- };
563
- }
564
- return runPpMethods;
565
- }
566
- onload(canvasHolder, canvas, sheath) {
567
- this.bbw = this.block.leftheadw + this.block.lpad + this.block.width + this.block.rpad + this.block.rightheadw + 2 * this.bbmargin;
568
- if (this.isYblock) {
569
- sheath.transition().style("height", `${this.bbw}px`);
570
- canvasHolder.style("height", `${this.bbw}px`);
571
- } else canvasHolder.style("width", `${this.bbw}px`);
572
- if (this.isYblock) {
573
- this.defaultTop = this.bbmargin + this.block.rightheadw + this.block.rpad;
574
- canvas.style("top", `${this.defaultTop}px`);
575
- } else {
576
- this.defaultLeft = this.bbmargin + this.block.leftheadw + this.block.lpad;
577
- canvas.style("left", `${this.defaultLeft}px`);
578
- }
579
- const config = {
580
- [this.isYblock ? "y" : "x"]: {
581
- chr: this.block.rglst[0].chr,
582
- start: this.block.rglst[0].start,
583
- stop: this.block.rglst[0].stop
584
- }
585
- };
586
- if (this.firstRender == false) {
587
- this.app.dispatch({
588
- type: "view_update",
589
- config
590
- });
591
- } else {
592
- this.firstRender = false;
593
- }
594
- }
595
- onpanning(xoff, canvas) {
596
- if (!this.isYblock) canvas.style("left", `${xoff + this.defaultLeft}px`);
597
- else canvas.style("top", `${-xoff + this.defaultTop}px`);
598
- }
599
- async loadBlock(chrObj, canvasHolder, canvas, sheath) {
600
- const runPpArgs = this.setArgs(chrObj);
601
- const runPpMethods = this.isYblock ? this.setMethods(canvasHolder, canvas, sheath) : this.setMethods(canvasHolder, canvas);
602
- const args = Object.assign(runPpArgs, runPpMethods);
603
- await blocklazyload(args).then(async (block) => {
604
- this.block = block;
605
- });
606
- }
607
- };
608
-
609
- // tracks/hic/data/DetailDataFetcher.ts
610
- var DetailDataFetcher = class {
611
- constructor(errList) {
612
- this.obj = {
613
- rglst: []
614
- };
615
- this.errList = errList;
616
- }
617
- isFragData(hic, resolution) {
618
- if (resolution != null) return;
619
- if (!hic.enzyme) {
620
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
621
- return;
622
- }
623
- }
624
- formatFragArgs(enzymefile, chr) {
625
- const arg = {
626
- getdata: 1,
627
- getBED: 1,
628
- file: enzymefile,
629
- rglst: [chr]
630
- };
631
- return arg;
632
- }
633
- /**
634
- * @param arg Formated obj from either fn above
635
- * @param errList
636
- * @returns
637
- */
638
- async getBedData(arg) {
639
- try {
640
- return await dofetch3("tkbedj", { method: "POST", body: JSON.stringify(arg) });
641
- } catch (e) {
642
- this.errList.push(e.message || e);
643
- if (e.stack) console.error(e.stack);
644
- }
645
- }
646
- async getXFragData(hic, resolution, chrx) {
647
- this.isFragData(hic, resolution);
648
- if (!hic.enzymefile) return;
649
- const reqArgs = this.formatFragArgs(hic.enzymefile, chrx);
650
- return await this.getBedData(reqArgs);
651
- }
652
- async getYFragData(hic, chry) {
653
- const reqArgs = this.formatFragArgs(hic.enzymefile, chry);
654
- return await this.getBedData(reqArgs);
655
- }
656
- /**
657
- * Separate request from data fetch
658
- * Returns the additional fragment data
659
- * @param fragCoords
660
- */
661
- async fetchData(hic, detailView, resolution, x, y, fragCoords) {
662
- const fragStrawArgs = {
663
- matrixType: detailView.matrixType,
664
- file: hic.file,
665
- url: hic.url,
666
- pos1: this.determinePosition(hic, x, fragCoords?.x),
667
- pos2: this.determinePosition(hic, y, fragCoords?.y),
668
- nmeth: detailView.nmeth,
669
- resolution
670
- };
671
- if (fragCoords) fragStrawArgs["isfrag"] = true;
672
- try {
673
- const data = dofetch3("hicdata?", {
674
- method: "POST",
675
- body: JSON.stringify(fragStrawArgs)
676
- });
677
- if (data.error) {
678
- this.errList.push(data.error);
679
- }
680
- return data;
681
- } catch (e) {
682
- this.errList.push(e.message || e);
683
- if (e.stack) console.error(e.stack);
684
- }
685
- }
686
- determinePosition(hic, chr, fragCoord) {
687
- if (fragCoord) {
688
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${fragCoord.start}:${fragCoord.stop}`;
689
- } else {
690
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${chr.start}:${chr.stop}`;
691
- }
692
- }
693
- };
694
-
695
- // tracks/hic/data/ParseFragData.ts
696
- var ParseFragData = class {
697
- constructor(errLst, items) {
698
- this.id2coord = /* @__PURE__ */ new Map();
699
- this.min = null;
700
- this.max = null;
701
- this.items = [];
702
- this.errLst = errLst;
703
- for (const i of items) {
704
- if (!i.rest || !i.rest[0]) {
705
- this.errLst.push("items[].rest data problem");
706
- }
707
- const id = Number.parseInt(i.rest[0]);
708
- if (Number.isNaN(id)) {
709
- this.errLst.push(`${i.start}.${i.stop} invalid fragment id: ${i.rest[0]}`);
710
- }
711
- this.id2coord.set(id, [i.start, i.stop]);
712
- if (this.min == null) {
713
- this.min = id;
714
- this.max = id;
715
- } else {
716
- this.min = Math.min(this.min, id);
717
- this.max = Math.max(this.max, id);
718
- }
719
- }
720
- }
721
- };
722
-
723
- // tracks/hic/data/DetailDataMapper.ts
724
- var DetailDataMapper = class {
725
- constructor(hic, errList, parent) {
726
- this.frag = {
727
- x: {},
728
- y: {}
729
- };
730
- this.hic = hic;
731
- this.errList = errList;
732
- this.dataFetcher = new DetailDataFetcher(errList);
733
- this.parent = parent;
734
- }
735
- async getFragData(chrx, chry) {
736
- try {
737
- const xFragData = await this.dataFetcher.getXFragData(this.hic, this.parent("calcResolution"), chrx);
738
- if (xFragData) {
739
- if (!xFragData.items) {
740
- this.errList.push(`No fragment data returned for ${chrx.chr}:${chrx.start}-${chrx.stop}`);
741
- return;
742
- }
743
- const xParse = new ParseFragData(this.errList, xFragData.items);
744
- if (this.errList.length) return;
745
- this.frag.x = {
746
- id2coord: xParse.id2coord,
747
- start: xParse.min,
748
- stop: xParse.max
749
- };
750
- const yFragData = await this.dataFetcher.getYFragData(this.hic, chry);
751
- if (this.errList.length) return;
752
- if (yFragData) {
753
- if (!yFragData.items) {
754
- this.errList.push(`No fragment data returned for ${chry.chr}:${chry.start}-${chry.stop}`);
755
- return;
756
- }
757
- const yParse = new ParseFragData(this.errList, yFragData.items);
758
- if (this.errList.length) return;
759
- this.frag.y = {
760
- id2coord: /* @__PURE__ */ new Map(),
761
- start: yParse.min,
762
- stop: yParse.max
763
- };
764
- this.determineMap(yParse.id2coord, chrx, chry);
765
- }
766
- }
767
- } catch (e) {
768
- this.errList.push(e.message || e);
769
- if (e.stack) console.error(e.stack);
770
- }
771
- }
772
- determineMap(map, chrx, chry) {
773
- if (chrx.chr == chry.chr) {
774
- for (const [id, pos] of map) {
775
- this.frag.x["id2coord"].set(id, pos);
776
- }
777
- this.frag.y["id2coord"] = this.frag.x["id2coord"];
778
- } else {
779
- this.frag.y["id2coord"] = map;
780
- }
781
- }
782
- async getData(chrx, chry, fragCoords) {
783
- return await this.dataFetcher.fetchData(
784
- this.hic,
785
- this.parent("state")["detail"],
786
- this.parent("calcResolution"),
787
- chrx,
788
- chry,
789
- fragCoords
790
- );
791
- }
792
- };
793
-
794
- // tracks/hic/data/DetailCoodinates.ts
795
- var DetailCoordinates = class {
796
- constructor(hic, errlist) {
797
- this.hic = hic;
798
- this.errlist = errlist;
799
- }
800
- getCoordinates(chrx, chry, data, resolution, widthHeightPx, fragData) {
801
- const isFirstX = new FirstChrX(this.hic.chrorder, chrx.chr, chry.chr).isFirstX();
802
- const isintrachr = chrx.chr == chry.chr;
803
- const xpxbp = widthHeightPx / (chrx.stop - chrx.start);
804
- const ypxbp = widthHeightPx / (chry.stop - chry.start);
805
- const list = this.calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData);
806
- return list;
807
- }
808
- calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData) {
809
- const list = [];
810
- for (const [xCoord, yCoord, value] of data.items) {
811
- let coord1, coord2, span1, span2;
812
- if (fragData) {
813
- const idx_start = isFirstX ? xCoord : yCoord;
814
- const idy_start = isFirstX ? yCoord : xCoord;
815
- if (fragData.x.id2coord.has(idx_start)) {
816
- const [a, b] = fragData.x.id2coord.get(idx_start);
817
- coord1 = a;
818
- span1 = b - a;
819
- } else {
820
- this.errlist.push(`[x id error] x: ${idx_start} y: ${idy_start}`);
821
- continue;
822
- }
823
- {
824
- const id_stop = idx_start + resolution;
825
- if (fragData.x.id2coord.has(id_stop)) {
826
- const ab = fragData.x.id2coord.get(id_stop);
827
- span1 = ab[1] - coord1;
828
- }
829
- }
830
- if (fragData.y.id2coord.has(idy_start)) {
831
- const [a, b] = fragData.y.id2coord.get(idy_start);
832
- coord2 = a;
833
- span2 = b - a;
834
- } else {
835
- this.errlist.push(`[y id error] x: ${idx_start} y: ${idy_start}`);
836
- continue;
837
- }
838
- {
839
- const id_stop = idy_start + resolution;
840
- if (fragData.y.id2coord.has(id_stop)) {
841
- const ab = fragData.y.id2coord.get(id_stop);
842
- span2 = ab[1] - coord2;
843
- }
844
- }
845
- } else {
846
- coord1 = isFirstX ? xCoord : yCoord;
847
- coord2 = isFirstX ? yCoord : xCoord;
848
- span1 = resolution;
849
- span2 = resolution;
850
- }
851
- if (isintrachr) {
852
- if (coord1 > chrx.start - span1 && coord1 < chrx.stop && coord2 > chry.start - span2 && coord2 < chry.stop) {
853
- list.push([
854
- Math.floor((coord1 - chrx.start) * xpxbp),
855
- Math.floor((coord2 - chry.start) * ypxbp),
856
- Math.ceil(span1 * xpxbp),
857
- Math.ceil(span2 * ypxbp),
858
- value
859
- ]);
860
- }
861
- if (coord2 > chrx.start - span2 && coord2 < chrx.stop && coord1 > chry.start && coord1 < chry.stop) {
862
- list.push([
863
- Math.floor((coord2 - chrx.start) * xpxbp),
864
- Math.floor((coord1 - chry.start) * ypxbp),
865
- Math.ceil(span2 * xpxbp),
866
- Math.ceil(span1 * ypxbp),
867
- value
868
- ]);
869
- }
870
- continue;
871
- }
872
- list.push([
873
- Math.floor((coord1 - chrx.start) * xpxbp),
874
- Math.floor((coord2 - chry.start) * ypxbp),
875
- Math.ceil(span1 * xpxbp),
876
- Math.ceil(span2 * ypxbp),
877
- value
878
- ]);
879
- }
880
- return list;
881
- }
882
- };
883
-
884
- // tracks/hic/detail/DetailView.ts
885
- var DetailView = class {
886
- constructor(opts) {
887
- this.calcResolution = null;
888
- /** Defaults **/
889
- this.binpx = 2;
890
- this.bbmargin = 1;
891
- this.app = opts.app;
892
- this.hic = opts.hic;
893
- this.plotDiv = opts.plotDiv;
894
- this.sheath = opts.plotDiv.yAxis.append("div").style("position", "relative").style("width", "200px").style("height", "800px");
895
- this.rotor = this.sheath.append("div").style("position", "absolute").style("bottom", "0px").style("transform", "rotate(-90deg)").style("transform-origin", "left bottom");
896
- this.data = opts.data;
897
- this.parent = opts.parent;
898
- this.errList = this.parent("errList");
899
- this.resolution = new Resolution(opts.error);
900
- this.colorizeElement = new ColorizeElement();
901
- this.viewRangeBpW = this.resolution.getDefaultViewSpan(
902
- this.hic,
903
- this.parent("state").x,
904
- this.parent("state").y,
905
- this.parent("state").initialBinNum,
906
- this.parent("state").minBinNum_bp
907
- );
908
- this.dataMapper = new DetailDataMapper(this.hic, opts.error, opts.parent);
909
- this.coordinates = new DetailCoordinates(this.hic, this.errList);
910
- }
911
- renderCanvas(blockwidth) {
912
- this.canvasHolder = this.plotDiv.plot.append("div").style("position", "relative").style("width", `${this.xBlock.bbw}px`).style("height", `${this.yBlock.bbw}px`).style("overflow", "hidden");
913
- this.canvas = this.canvasHolder.append("canvas").style("display", "block").style("position", "absolute").attr("data-testid", "sjpp-hic-detail-canvas").attr("width", blockwidth).attr("height", blockwidth).on("mousedown", (event) => {
914
- const body = select_default(document.body);
915
- const x = event.clientX;
916
- const y = event.clientY;
917
- const oldx = Number.parseInt(this.canvas.style("left"));
918
- const oldy = Number.parseInt(this.canvas.style("top"));
919
- body.on("mousemove", (event2) => {
920
- const xoff = event2.clientX - x;
921
- const yoff = event2.clientY - y;
922
- this.xBlock.block.panning(xoff);
923
- this.yBlock.block.panning(yoff);
924
- this.canvas.style("left", `${oldx + xoff}px`).style("top", `${oldy + yoff}px`);
925
- });
926
- body.on("mouseup", (event2) => {
927
- body.on("mousemove", null).on("mouseup", null);
928
- const xoff = event2.clientX - x;
929
- const yoff = event2.clientY - y;
930
- this.xBlock.block.pannedby(xoff);
931
- this.yBlock.block.pannedby(yoff);
932
- });
933
- });
934
- }
935
- async render() {
936
- this.calcResolution = this.parent("calcResolution");
937
- const state = this.parent("state");
938
- this.xBlock = new DetailBlock(
939
- this.app,
940
- this.hic,
941
- state.settings.widthHeightPx,
942
- this.bbmargin,
943
- this.plotDiv.xAxis,
944
- false
945
- );
946
- this.yBlock = new DetailBlock(this.app, this.hic, state.settings.widthHeightPx, this.bbmargin, this.rotor, true);
947
- this.renderCanvas(state.settings.widthHeightPx);
948
- await this.xBlock.loadBlock(state.x, this.canvasHolder, this.canvas);
949
- await this.yBlock.loadBlock(state.y, this.canvasHolder, this.canvas, this.sheath);
950
- this.update(this.data);
951
- }
952
- async update(data) {
953
- if (data.items.length == 0) {
954
- this.app.dispatch({ type: "loading_active", active: false });
955
- return;
956
- }
957
- this.data = data;
958
- const state = this.parent("state");
959
- const initialWidth = Number.parseInt(this.canvas.attr("width"));
960
- const holderChange = Number.parseInt(this.canvasHolder.style("width")) - initialWidth + state.settings.widthHeightPx;
961
- this.canvasHolder.style("width", `${holderChange}px`).style("height", `${holderChange}px`);
962
- this.canvas.attr("width", `${state.settings.widthHeightPx}px`).attr("height", `${state.settings.widthHeightPx}px`);
963
- if (this.xBlock.block.width != state.settings.widthHeightPx) {
964
- this.xBlock.block.width = state.settings.widthHeightPx;
965
- this.yBlock.block.width = state.settings.widthHeightPx;
966
- this.xBlock.block.zoom2px(0, initialWidth);
967
- this.yBlock.block.zoom2px(0, initialWidth);
968
- }
969
- this.ctx = this.canvas.node().getContext("2d");
970
- const coords = this.coordinates.getCoordinates(
971
- state.x,
972
- state.y,
973
- this.parent("data"),
974
- this.parent("calcResolution"),
975
- state.settings.widthHeightPx,
976
- this.parent("fragData")
977
- );
978
- this.coords = coords;
979
- this.ctx.clearRect(0, 0, state.settings.widthHeightPx, state.settings.widthHeightPx);
980
- for (const [xCoord, yCoord, width, height, value] of this.coords) {
981
- this.colorizeElement.colorizeElement(
982
- xCoord,
983
- yCoord,
984
- value,
985
- this.ctx,
986
- width,
987
- height,
988
- this.parent("min"),
989
- this.parent("max"),
990
- "detail"
991
- );
992
- }
993
- this.app.dispatch({ type: "loading_active", active: false });
994
- }
995
- };
996
-
997
- // tracks/hic/axes/Chromosome.ts
998
- var Chromosome = class {
999
- constructor(chr, width) {
1000
- this.label = chr;
1001
- this.width = width;
1002
- }
1003
- };
1004
-
1005
- // tracks/hic/grid/Grid.ts
1006
- var Grid = class _Grid {
1007
- constructor(chrlst, resolution, chrlookup, binpx) {
1008
- this.chromosomeMatrix = /* @__PURE__ */ new Map();
1009
- this.chromosomeList = [];
1010
- this.xoff = 0;
1011
- this.yoff = 0;
1012
- this.chr2px = [];
1013
- this.chrlst = chrlst;
1014
- let totalpx = this.chrlst.length;
1015
- for (const chr of this.chrlst) {
1016
- const w = Math.ceil(chrlookup[chr.toUpperCase()].len / resolution) * binpx;
1017
- const chromosome = new Chromosome(chr, w);
1018
- this.chromosomeList.push(chromosome);
1019
- this.chr2px[chr] = w;
1020
- totalpx += w;
1021
- }
1022
- this.totalpx = totalpx;
1023
- for (let i = 0; i < this.chrlst.length; i++) {
1024
- const chrx = this.chrlst[i];
1025
- this.chromosomeMatrix.set(chrx, /* @__PURE__ */ new Map());
1026
- let yoff = 0;
1027
- for (let j = 0; j <= i; j++) {
1028
- const chry = this.chrlst[j];
1029
- const chrxChrLen = chrlookup[chrx.toUpperCase()].len;
1030
- const chryChrLen = chrlookup[chry.toUpperCase()].len;
1031
- const xbins = Math.ceil(chrxChrLen / resolution) * binpx;
1032
- const ybins = Math.ceil(chryChrLen / resolution) * binpx;
1033
- this.chromosomeMatrix.get(chrx).set(chry, {
1034
- x: this.xoff,
1035
- y: yoff,
1036
- xbins,
1037
- ybins,
1038
- data: []
1039
- //Empty array of data to fill later
1040
- });
1041
- yoff += this.chr2px[chry] + _Grid.borderWidth;
1042
- }
1043
- this.yoff = yoff;
1044
- this.xoff += this.chr2px[chrx] + _Grid.borderWidth;
1045
- }
1046
- }
1047
- static {
1048
- this.checkerFill = "#DEF3FA";
1049
- }
1050
- static {
1051
- this.spaceColor = "#CCC";
1052
- }
1053
- static {
1054
- this.fontSize = 15;
1055
- }
1056
- static {
1057
- this.font = font;
1058
- }
1059
- static {
1060
- this.borderWidth = 1;
1061
- }
1062
- static {
1063
- this.defaultChrLabWidth = 100;
1064
- }
1065
- };
1066
-
1067
- // tracks/hic/viewmodel/GridViewModel.ts
1068
- var GridViewModel = class {
1069
- constructor(opts) {
1070
- this.grid = new Grid(opts.hic.chrlst, opts.resolution || opts.hic.bpresolution[0], opts.hic.genome.chrlookup, 1);
1071
- }
1072
- };
1073
-
1074
- // tracks/hic/grid/GridRenderer.ts
1075
- var GridRenderer = class {
1076
- constructor(svg, layerMap, layerSv, grid) {
1077
- this.svg = svg;
1078
- this.layerMap = layerMap.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1079
- this.layerSv = layerSv.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1080
- this.grid = grid;
1081
- }
1082
- render() {
1083
- this.renderAxisX(this.grid);
1084
- this.renderAxisY(this.grid);
1085
- this.svg.attr("width", Grid.defaultChrLabWidth + this.grid.xoff).attr("height", Grid.fontSize + this.grid.yoff);
1086
- }
1087
- renderAxisX(grid) {
1088
- let xoff = 0;
1089
- this.grid.chromosomeList.forEach((chr, index) => {
1090
- const chrw = chr.width;
1091
- if (index % 2 === 0) {
1092
- this.layerMap.append("rect").attr("x", xoff).attr("width", chrw).attr("height", Grid.fontSize).attr("y", -Grid.fontSize).attr("fill", Grid.checkerFill);
1093
- }
1094
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-xAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "middle").attr("font-size", 12).attr("x", xoff + chrw / 2).text(chr.label);
1095
- xoff += chrw;
1096
- this.layerSv.append("line").attr("x1", xoff).attr("x2", xoff).attr("y2", grid.totalpx).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1097
- xoff += Grid.borderWidth;
1098
- });
1099
- }
1100
- renderAxisY(grid) {
1101
- let yoff = 0;
1102
- this.grid.chromosomeList.forEach((chr, index) => {
1103
- const chrh = chr.width;
1104
- if (index % 2 === 0) {
1105
- this.layerMap.append("rect").attr("x", -Grid.defaultChrLabWidth).attr("width", Grid.defaultChrLabWidth).attr("height", chrh).attr("y", yoff).attr("fill", Grid.checkerFill);
1106
- }
1107
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-yAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "end").attr("dominant-baseline", "central").attr("font-size", 12).attr("y", yoff + chrh / 2).text(chr.label);
1108
- yoff += chrh;
1109
- this.layerSv.append("line").attr("x2", grid.totalpx).attr("y1", yoff).attr("y2", yoff).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1110
- yoff += Grid.borderWidth;
1111
- });
1112
- }
1113
- };
1114
-
1115
- // tracks/hic/genome/ChrsTooltips.ts
1116
- var ChrsTooltips = class {
1117
- constructor() {
1118
- this.chrx_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1119
- this.chry_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1120
- }
1121
- render(img, chrx, chry) {
1122
- const p = img.node().getBoundingClientRect();
1123
- this.chrx_tip.clear().show(p.left, p.top).d.style("top", null).attr("data-testid", "sjpp-hic-chrx-tooltip").style("bottom", window.innerHeight - p.top - window.pageYOffset + "px").text(chrx);
1124
- this.chry_tip.clear().show(p.left, p.top).d.style("left", null).attr("data-testid", "sjpp-hic-chry-tooltip").style("right", document.body.clientWidth - p.left - window.pageXOffset + "px").text(chry);
1125
- }
1126
- };
1127
-
1128
- // tracks/hic/grid/GridElementRenderer.ts
1129
- var GridElementRenderer = class {
1130
- constructor(layerMap, app) {
1131
- this.app = app;
1132
- this.layerMap = layerMap;
1133
- this.tooltips = new ChrsTooltips();
1134
- }
1135
- render(obj, lead, follow, holder) {
1136
- obj.canvas = holder.append("canvas").style("display", "none").node();
1137
- obj.ctx = obj.canvas.getContext("2d");
1138
- obj.canvas.width = obj.xbins;
1139
- obj.canvas.height = obj.ybins;
1140
- obj.img = this.layerMap.append("image").attr("width", obj.canvas.width).attr("height", obj.canvas.height).attr("x", obj.x).attr("y", obj.y).on("click", async () => {
1141
- await this.app.dispatch({
1142
- type: "view_create",
1143
- view: "chrpair",
1144
- config: {
1145
- x: {
1146
- chr: lead
1147
- },
1148
- y: {
1149
- chr: follow
1150
- }
1151
- }
1152
- });
1153
- }).on("mouseover", () => {
1154
- this.tooltips.render(obj.img, lead, follow);
1155
- });
1156
- if (lead != follow) {
1157
- obj.canvas2 = holder.append("canvas").style("display", "none").node();
1158
- obj.canvas2.width = obj.ybins;
1159
- obj.canvas2.height = obj.xbins;
1160
- obj.ctx2 = obj.canvas2.getContext("2d");
1161
- obj.img2 = this.layerMap.append("image").attr("width", obj.canvas2.width).attr("height", obj.canvas2.height).attr("x", obj.y).attr("y", obj.x).on("click", async () => {
1162
- await this.app.dispatch({
1163
- type: "view_create",
1164
- view: "chrpair",
1165
- config: {
1166
- x: {
1167
- chr: follow
1168
- },
1169
- y: {
1170
- chr: lead
1171
- }
1172
- }
1173
- });
1174
- }).on("mouseover", () => {
1175
- this.tooltips.render(obj.img2, follow, lead);
1176
- });
1177
- } else {
1178
- obj.ctx2 = obj.ctx;
1179
- }
1180
- }
1181
- };
1182
-
1183
- // tracks/hic/grid/GridElementsRenderer.ts
1184
- var GridElementsRenderer = class {
1185
- constructor(grid, layerMap, app) {
1186
- this.grid = grid;
1187
- this.gridElementRenderer = new GridElementRenderer(layerMap, app);
1188
- }
1189
- render(holder) {
1190
- for (const [chrx, chryMap] of this.grid.chromosomeMatrix) {
1191
- for (const [chry, gridElem] of chryMap) {
1192
- this.gridElementRenderer.render(gridElem, chrx, chry, holder);
1193
- }
1194
- }
1195
- }
1196
- };
1197
-
1198
- // tracks/hic/genome/GenomeView.ts
1199
- var GenomeView = class {
1200
- constructor(opts) {
1201
- /** Dom */
1202
- this.tip = new Menu();
1203
- this.pica_x = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1204
- this.pica_y = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1205
- /** Data */
1206
- /** px width for each chr */
1207
- this.chr2px = {};
1208
- this.lead2follow = /* @__PURE__ */ new Map();
1209
- this.values = [];
1210
- /** Defaults */
1211
- this.defaultChrLabWidth = 100;
1212
- this.borderwidth = 1;
1213
- this.default_maxVPerc = 5;
1214
- this.fontsize = 15;
1215
- this.xoff = 0;
1216
- this.yoff = 0;
1217
- this.binpx = 1;
1218
- this.atdev_chrnum = 8;
1219
- this.min = 0;
1220
- this.max = 0;
1221
- this.app = opts.app;
1222
- this.hic = opts.hic;
1223
- this.plotDiv = opts.plotDiv;
1224
- this.data = opts.data;
1225
- this.parent = opts.parent;
1226
- this.resolution = opts.resolution || opts.hic.bpresolution[0];
1227
- this.svg = this.plotDiv.plot.append("svg").attr("data-testid", "sjpp-hic-genome-svg");
1228
- this.layer_map = this.svg.append("g").attr("data-testid", "sjpp-hic-layerMap-g");
1229
- this.layer_sv = this.svg.append("g").attr("data-testid", "sjpp-hic-layerSv-g");
1230
- this.colorizeElement = new ColorizeElement();
1231
- this.viewModel = new GridViewModel(opts);
1232
- this.viewRender = new GridRenderer(this.svg, this.layer_map, this.layer_sv, this.viewModel.grid);
1233
- this.gridElementsRenderer = new GridElementsRenderer(this.viewModel.grid, this.layer_map, this.app);
1234
- this.gridFormattedData = new GridElementsFormattedData();
1235
- }
1236
- makeSv() {
1237
- const unknownchr = /* @__PURE__ */ new Set();
1238
- const radius = 8;
1239
- for (const item of this.hic.sv.items) {
1240
- const _o = this.lead2follow.get(item.chr1);
1241
- if (!_o) {
1242
- unknownchr.add(item.chr1);
1243
- continue;
1244
- }
1245
- const obj = _o.get(item.chr2);
1246
- if (!obj) {
1247
- unknownchr.add(item.chr2);
1248
- continue;
1249
- }
1250
- const p1 = item.position1 / this.resolution;
1251
- const p2 = item.position2 / this.resolution;
1252
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cx", obj.x + p1).attr("cy", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1253
- this.tooltipSv(event, item);
1254
- }).on("mouseout", () => {
1255
- this.tip.hide();
1256
- }).on("click", () => {
1257
- this.clickSv(item);
1258
- });
1259
- if (obj.img2) {
1260
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle-2").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cy", obj.x + p1).attr("cx", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1261
- this.tooltipSv(event, item);
1262
- }).on("mouseout", () => {
1263
- this.tip.hide();
1264
- }).on("click", () => {
1265
- this.clickSv(item);
1266
- });
1267
- }
1268
- }
1269
- }
1270
- tooltipSv(event, item) {
1271
- this.tip.clear().show(event.clientX, event.clientY).d.append("div").text(
1272
- item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`
1273
- );
1274
- }
1275
- clickSv(item) {
1276
- const default_svpointspan = 5e5;
1277
- const default_subpanelpxwidth = 600;
1278
- const subpanel_bordercolor = "rgba(200,0,0,.1)";
1279
- const pane = newpane({ x: 100, y: 100 });
1280
- pane.header.text(
1281
- this.hic.name + " " + (item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`)
1282
- );
1283
- const tracks = [
1284
- {
1285
- type: tkt.hicstraw,
1286
- file: this.hic.file,
1287
- enzyme: this.hic.enzyme,
1288
- maxpercentage: this.default_maxVPerc,
1289
- pyramidup: 1,
1290
- name: this.hic.name
1291
- }
1292
- ];
1293
- if (this.hic.tklst) {
1294
- for (const t of this.hic.tklst) {
1295
- tracks.push(t);
1296
- }
1297
- }
1298
- first_genetrack_tolist(this.hic.genome, tracks);
1299
- const arg = {
1300
- holder: pane.body,
1301
- hostURL: this.hic.hostURL,
1302
- jwt: this.hic.jwt,
1303
- genome: this.hic.genome,
1304
- nobox: 1,
1305
- tklst: tracks
1306
- };
1307
- if (item.chr1 == item.chr2 && Math.abs(item.position2 - item.position1) < default_svpointspan * 2) {
1308
- arg.chr = item.chr1;
1309
- const w = Math.abs(item.position2 - item.position1);
1310
- arg.start = Math.max(1, Math.min(item.position1, item.position2) - w);
1311
- arg.stop = Math.min(
1312
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1313
- Math.max(item.position1, item.position2) + w
1314
- );
1315
- } else {
1316
- arg.chr = item.chr1;
1317
- arg.start = Math.max(1, item.position1 - default_svpointspan / 2);
1318
- arg.stop = Math.min(
1319
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1320
- item.position1 + default_svpointspan / 2
1321
- );
1322
- arg.width = default_subpanelpxwidth;
1323
- arg.subpanels = [
1324
- {
1325
- chr: item.chr2,
1326
- start: Math.max(1, item.position2 - default_svpointspan / 2),
1327
- stop: Math.min(
1328
- this.hic.genome.chrlookup[item.chr2.toUpperCase()].len,
1329
- item.position2 + default_svpointspan / 2
1330
- ),
1331
- width: default_subpanelpxwidth,
1332
- leftpad: 10,
1333
- leftborder: subpanel_bordercolor
1334
- }
1335
- ];
1336
- }
1337
- blocklazyload(arg);
1338
- }
1339
- render() {
1340
- this.viewRender.render();
1341
- this.gridElementsRenderer.render(this.hic.holder);
1342
- if (this.hic.sv && this.hic.sv.items) {
1343
- this.makeSv();
1344
- }
1345
- this.update(this.data);
1346
- }
1347
- update(data) {
1348
- this.data = data;
1349
- this.min = this.parent("min");
1350
- this.max = this.parent("max");
1351
- for (const data2 of this.data) {
1352
- if (!this.hic.chrlst.includes(data2.lead) || !this.hic.chrlst.includes(data2.follow)) continue;
1353
- const obj = this.viewModel.grid.chromosomeMatrix.get(data2.lead).get(data2.follow);
1354
- if (!obj) continue;
1355
- obj.ctx.clearRect(0, 0, obj.canvas.width, obj.canvas.height);
1356
- if (obj.canvas2) {
1357
- obj.ctx2.clearRect(0, 0, obj.canvas2.width, obj.canvas.height);
1358
- }
1359
- obj.data = this.gridFormattedData.formatData("genome", data2.items, this.binpx, this.resolution);
1360
- for (const [xPx, yPx, value] of obj.data) {
1361
- this.colorizeElement.colorizeElement(xPx, yPx, value, obj, this.binpx, this.binpx, this.min, this.max, "genome");
1362
- }
1363
- obj.img.attr("xlink:href", obj.canvas.toDataURL());
1364
- if (obj.canvas2) {
1365
- obj.img2.attr("xlink:href", obj.canvas2.toDataURL());
1366
- }
1367
- }
1368
- this.app.dispatch({ type: "loading_active", active: false });
1369
- }
1370
- };
1371
-
1372
- // tracks/hic/controls/NormalizationMethodControl.ts
1373
- var NormalizationMethodControl = class {
1374
- constructor(holder, normalization, defaultNmeth, callback) {
1375
- this.holder = holder;
1376
- this.normalization = normalization;
1377
- this.defaultNmeth = defaultNmeth;
1378
- this.callback = callback;
1379
- }
1380
- render() {
1381
- if (!this.normalization?.length) {
1382
- this.nmethSelect = this.holder.text(this.defaultNmeth);
1383
- } else {
1384
- this.nmethSelect = this.holder.attr("data-testid", "sjpp-hic-nmeth-select").style("margin-right", "10px").append("select").on("change", async () => {
1385
- const nmeth = this.nmethSelect.node().value;
1386
- this.callback(nmeth, "nmeth");
1387
- });
1388
- for (const n of this.normalization) {
1389
- this.nmethSelect.append("option").text(n);
1390
- }
1391
- }
1392
- }
1393
- update(option) {
1394
- const options = this.nmethSelect.node().options;
1395
- if (!options) return;
1396
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1397
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1398
- selectedNmeth.selected = true;
1399
- }
1400
- };
1401
-
1402
- // tracks/hic/controls/CutoffControl.ts
1403
- var CutoffControl = class {
1404
- constructor(holder, value, callback) {
1405
- this.holder = holder;
1406
- this.value = value;
1407
- this.callback = callback;
1408
- }
1409
- render(opts) {
1410
- const cutoffDiv = this.holder.attr("data-testid", "sjpp-hic-cutoff-control").style("margin-right", "10px").append("input").attr("type", "number").style("width", opts && "width" in opts ? opts.width : "80px").style("margin-left", "0px").attr("type", "number").property("value", this.value).on("keyup", async (event) => {
1411
- if (event.code != "Enter") return;
1412
- const v = event.target.value;
1413
- this.callback(v);
1414
- });
1415
- return cutoffDiv;
1416
- }
1417
- };
1418
-
1419
- // tracks/hic/controls/MatrixTypeControl.ts
1420
- var MatrixTypeControl = class {
1421
- constructor(holder, callback) {
1422
- this.values = [
1423
- { label: "Observed", value: "observed" },
1424
- { label: "Expected", value: "expected" },
1425
- { label: "Observed/Expected", value: "oe" },
1426
- { label: "Log(Observed/Expected)", value: "log(oe)" }
1427
- // TODO: add server side logic to support these options
1428
- // { label: 'Log(Observed + 1)', value: 'log(obs+1)'},
1429
- // { label: 'Observed Pearson', value: 'op'}
1430
- ];
1431
- this.holder = holder;
1432
- this.callback = callback;
1433
- }
1434
- render() {
1435
- this.matrixSelect = this.holder.attr("data-testid", "sjpp-hic-matrix-type-select").style("margin-right", "10px").append("select").on("change", async () => {
1436
- this.callback(this.matrixSelect.node().value, "matrixType");
1437
- });
1438
- for (const matrixType of this.values) {
1439
- this.matrixSelect.append("option").text(matrixType.label).attr("value", matrixType.value);
1440
- }
1441
- }
1442
- update(option) {
1443
- const options = this.matrixSelect.node().options;
1444
- if (!options) return;
1445
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1446
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1447
- selectedNmeth.selected = true;
1448
- }
1449
- };
1450
-
1451
- // tracks/hic/controls/ControlPanel.ts
1452
- var ControlPanel = class _ControlPanel {
1453
- constructor(opts) {
1454
- this.zoomBlockCallback = (bool) => {
1455
- const detailView = this.parent("detail");
1456
- detailView.xBlock.block.zoomblock(2, bool);
1457
- detailView.yBlock.block.zoomblock(2, bool);
1458
- };
1459
- this.minCallback = (v) => {
1460
- if (Number(v) > Number(this.parent("max"))) {
1461
- this.error("Min cutoff cannot be greater than max cutoff");
1462
- } else {
1463
- this.parent("min", Number(v));
1464
- this.reColorHeatmap();
1465
- this.parent("infoBar").update();
1466
- }
1467
- };
1468
- this.maxCallback = (v) => {
1469
- if (Number(v) < Number(this.parent("min"))) {
1470
- this.error(`Max cutoff cannot be less than min cutoff`);
1471
- } else if (Number(v) < 0) {
1472
- this.error(`Max cutoff cannot be less than 0`);
1473
- } else {
1474
- this.parent("max", Number(v));
1475
- this.reColorHeatmap();
1476
- this.parent("infoBar").update();
1477
- }
1478
- };
1479
- this.reColorHeatmap = () => {
1480
- if (this.parent("activeView") == "genome") {
1481
- const genomeView = this.parent("genome");
1482
- const chrMatrix = genomeView.viewRender.grid.chromosomeMatrix;
1483
- if (!chrMatrix) return;
1484
- for (const map of chrMatrix) {
1485
- const yMap = map[1];
1486
- for (const obj of yMap) {
1487
- const canvasObj = obj[1];
1488
- if (!canvasObj) continue;
1489
- for (const [leadpx, followpx, val] of canvasObj.data) {
1490
- this.colorizeElement.colorizeElement(
1491
- leadpx,
1492
- followpx,
1493
- val,
1494
- canvasObj,
1495
- 1,
1496
- 1,
1497
- this.parent("min"),
1498
- this.parent("max"),
1499
- "genome"
1500
- );
1501
- }
1502
- canvasObj.img.attr("xlink:href", canvasObj.canvas.toDataURL());
1503
- if (canvasObj.canvas2) {
1504
- canvasObj.img2.attr("xlink:href", canvasObj.canvas2.toDataURL());
1505
- }
1506
- }
1507
- }
1508
- } else if (this.parent("activeView") == "chrpair") {
1509
- const view = this.parent("chrpair");
1510
- for (const [xCoord, yCoord, val] of view.data) {
1511
- this.colorizeElement.colorizeElement(
1512
- xCoord,
1513
- yCoord,
1514
- val,
1515
- view.ctx,
1516
- view.binpx,
1517
- view.binpx,
1518
- this.parent("min"),
1519
- this.parent("max"),
1520
- "chrpair"
1521
- );
1522
- }
1523
- } else if (this.parent("activeView") == "detail") {
1524
- const view = this.parent("detail");
1525
- for (const [xCoord, yCoord, width, height, value] of view.coords) {
1526
- this.colorizeElement.colorizeElement(
1527
- xCoord,
1528
- yCoord,
1529
- value,
1530
- view.ctx,
1531
- width,
1532
- height,
1533
- this.parent("min"),
1534
- this.parent("max"),
1535
- "detail"
1536
- );
1537
- }
1538
- }
1539
- };
1540
- this.dropdownCallback = (v, prop) => {
1541
- const state = this.app.getState();
1542
- this.app.dispatch({
1543
- type: "view_update",
1544
- view: state.currView,
1545
- config: { [prop]: v }
1546
- });
1547
- };
1548
- this.type = _ControlPanel.type;
1549
- this.controls = {};
1550
- this.app = opts.app;
1551
- this.controlsDiv = opts.controlsDiv;
1552
- this.hic = opts.hic;
1553
- this.colorizeElement = new ColorizeElement();
1554
- this.parent = opts.parent;
1555
- this.error = opts.error;
1556
- }
1557
- static {
1558
- this.type = "controlPanel";
1559
- }
1560
- getState(appState) {
1561
- return appState;
1562
- }
1563
- addLabel(tr, text) {
1564
- return tr.append("td").style("color", "#858585").style("font-size", ".8em").style("vertical-align", text.toUpperCase() == "VIEW" ? "top" : "middle").text(text.toUpperCase());
1565
- }
1566
- init() {
1567
- const state = this.app.getState();
1568
- const menuWrapper = this.controlsDiv.attr("data-testid", "sjpp-hic-control-panel").style("background", "rgb(253, 250, 244)").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc");
1569
- let menuVisible = true;
1570
- this.controlsDiv.append("button").attr("data-testid", "sjpp-hic-burger-btn").style("display", "block").style("border", "none").style("font-size", "1.5em").style("background", "none").html("&#8801;").on("click", () => {
1571
- menuVisible = !menuVisible;
1572
- menu.style("display", menuVisible ? "block" : "none");
1573
- });
1574
- const menu = menuWrapper.append("div").attr("class", "sjpp-hic-menu").attr("data-testid", "sjpp-hic-menu").style("display", menuVisible ? "block" : "none");
1575
- const menuTable = menu.append("table").style("border-spacing", "3px");
1576
- this.controls.normalizationRow = menuTable.append("tr");
1577
- this.addLabel(this.controls.normalizationRow, "NORMALIZATION");
1578
- this.controls.nmeth = new NormalizationMethodControl(
1579
- this.controls.normalizationRow.append("td").attr("class", "sjpp-nmeth-select"),
1580
- this.hic.normalization,
1581
- state.defaultNmeth,
1582
- this.dropdownCallback
1583
- );
1584
- this.controls.nmeth.render();
1585
- this.controls.minCutoffRow = menuTable.append("tr");
1586
- this.controls.minCutoffLabel = this.addLabel(this.controls.minCutoffRow, "");
1587
- this.controls.inputBpMinV = new CutoffControl(
1588
- this.controls.minCutoffRow.append("td"),
1589
- this.parent("min"),
1590
- this.minCallback
1591
- ).render({ width: "120px" });
1592
- this.controls.maxCutoffRow = menuTable.append("tr");
1593
- this.controls.maxCutoffLabel = this.addLabel(this.controls.maxCutoffRow, "");
1594
- this.controls.inputBpMaxV = new CutoffControl(
1595
- this.controls.maxCutoffRow.append("td"),
1596
- this.parent("max"),
1597
- this.maxCallback
1598
- ).render({ width: "120px" });
1599
- this.controls.matrixTypeRow = menuTable.append("tr");
1600
- this.addLabel(this.controls.matrixTypeRow, "matrix type");
1601
- this.controls.matrixType = new MatrixTypeControl(this.controls.matrixTypeRow.append("td"), this.dropdownCallback);
1602
- this.controls.matrixType.render();
1603
- this.controls.widthRow = menuTable.append("tr");
1604
- this.addLabel(this.controls.widthRow, "WIDTH / height");
1605
- this.controls.width = this.controls.widthRow.append("td");
1606
- this.controls.width.attr("data-testid", "sjpp-hic-block-size-input").style("margin-right", "10px").append("input").attr("type", "number").style("width", "80px").style("margin-left", "0px").attr("type", "number").property("value", state.width).on("keyup", async (event) => {
1607
- if (event.code != "Enter") return;
1608
- const v = event.target.value;
1609
- this.app.dispatch({
1610
- type: "view_update",
1611
- config: {
1612
- settings: { widthHeightPx: Number.parseInt(v) }
1613
- }
1614
- });
1615
- });
1616
- const viewRow = menuTable.append("tr");
1617
- this.addLabel(viewRow, "VIEW");
1618
- const viewBtnDiv = viewRow.append("td");
1619
- this.controls.view = viewBtnDiv.append("span").attr("data-testid", "sjpp-hic-view-span").style("padding-right", "5px").style("display", "block");
1620
- this.controls.genomeViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-genome-view-btn").style("display", "none").style("padding", "2px").style("margin-top", "4px").html("&#8810; Genome").on("click", async () => {
1621
- await this.app.dispatch({
1622
- type: "view_create",
1623
- view: "genome",
1624
- config: {
1625
- x: {},
1626
- y: {}
1627
- }
1628
- });
1629
- });
1630
- this.controls.chrpairViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-chrpair-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").on("click", async () => {
1631
- const currState = this.app.getState();
1632
- await this.app.dispatch({
1633
- type: "view_create",
1634
- view: "chrpair",
1635
- config: {
1636
- x: {
1637
- chr: currState.x.chr
1638
- },
1639
- y: {
1640
- chr: currState.y.chr
1641
- }
1642
- }
1643
- });
1644
- });
1645
- this.controls.horizontalViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-horizontal-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("Horizontal View &#8811;").on("click", async () => {
1646
- await this.app.dispatch({
1647
- type: "view_create",
1648
- view: "horizontal"
1649
- });
1650
- });
1651
- this.controls.detailViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-detail-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("&#8810; Detailed View").on("click", async () => {
1652
- await this.app.dispatch({
1653
- type: "view_create",
1654
- view: "detail"
1655
- });
1656
- });
1657
- this.controls.zoomDiv = menuTable.append("tr").attr("data-testid", "sjpp-hic-zoom-div").style("display", state.currView == "detail" ? "contents" : "none");
1658
- this.addLabel(this.controls.zoomDiv, "ZOOM");
1659
- const zoomDiv = this.controls.zoomDiv.append("td");
1660
- this.controls.zoomIn = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-in-btn").style("margin-right", "10px").text("In").on("click", () => {
1661
- this.zoomBlockCallback(false);
1662
- });
1663
- this.controls.zoomOut = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-out-btn").style("margin-right", "10px").text("Out").on("click", () => {
1664
- this.zoomBlockCallback(true);
1665
- });
1666
- }
1667
- showBtns() {
1668
- const state = this.app.getState();
1669
- this.controls.genomeViewBtn.style("display", state.currView === "genome" ? "none" : "inline-block");
1670
- if (state.currView === "detail") {
1671
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1672
- this.controls.horizontalViewBtn.style("display", "block");
1673
- this.controls.zoomDiv.style("display", "contents");
1674
- this.controls.detailViewBtn.style("display", "none");
1675
- } else if (state.currView === "horizontal") {
1676
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1677
- this.controls.detailViewBtn.style("display", "block");
1678
- this.controls.horizontalViewBtn.style("display", "none");
1679
- this.controls.zoomDiv.style("display", "none");
1680
- } else {
1681
- this.controls.chrpairViewBtn.style("display", "none");
1682
- this.controls.horizontalViewBtn.style("display", "none");
1683
- this.controls.detailViewBtn.style("display", "none");
1684
- this.controls.zoomDiv.style("display", "none");
1685
- this.controls.widthRow.style("display", "none");
1686
- }
1687
- }
1688
- showHideControls() {
1689
- const state = this.app.getState();
1690
- this.controls.normalizationRow.style("display", state.currView == "horizontal" ? "none" : "");
1691
- this.controls.minCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1692
- this.controls.maxCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1693
- this.controls.matrixTypeRow.style("display", state.currView == "horizontal" ? "none" : "");
1694
- this.controls.widthRow.style("display", state.currView == "detail" ? "contents" : "none");
1695
- }
1696
- main(appState) {
1697
- const state = this.app.getState(appState);
1698
- this.controls.nmeth.update(state[state.currView].nmeth);
1699
- this.controls.matrixType.update(state[state.currView].matrixType);
1700
- this.controls.zoomDiv.style("display", state.currView == "detail" ? "contents" : "none");
1701
- if (state.currView == "chrpair") {
1702
- this.controls.view.text(`${state.x.chr}-${state.y.chr} Pair`);
1703
- } else {
1704
- this.controls.view.text(state.currView.charAt(0).toUpperCase() + state.currView.slice(1));
1705
- }
1706
- const formatAbsMin = this.parent("absMin") < 1e-5 ? Number(this.parent("absMin")).toExponential(1) : Number(this.parent("absMin").toFixed(6));
1707
- const formatAbsMax = this.parent("absMax") < 1e-5 ? Number(this.parent("absMax")).toExponential(1) : Number(this.parent("absMax").toFixed(6));
1708
- this.controls.width.select("input").property("value", state.settings.widthHeightPx);
1709
- this.controls.inputBpMinV.property("value", this.parent("min"));
1710
- this.controls.inputBpMaxV.property("value", this.parent("max"));
1711
- this.controls.minCutoffLabel.html(`MIN CUTOFF <br>(>= ${formatAbsMin})`);
1712
- this.controls.maxCutoffLabel.html(`MAX CUTOFF <br>(<= ${formatAbsMax})`);
1713
- this.showBtns();
1714
- this.showHideControls();
1715
- }
1716
- };
1717
- var controlPanelInit = getCompInit(ControlPanel);
1718
-
1719
- // tracks/hic/dom/InfoBar.ts
1720
- var InfoBar = class {
1721
- constructor(opts) {
1722
- /** Defaults **/
1723
- //Color shown on the left of the color scale
1724
- this.startColor = "white";
1725
- //Color shown on the right of the color scale
1726
- this.endColor = "red";
1727
- this.addLabel = (text) => {
1728
- return this.labelRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toLowerCase().replace(/\s/g, "-")}-label`).style("color", "#858585").style("font-size", ".8em").style("text-align", "center").style("vertical-align", "middle").text(text.toUpperCase());
1729
- };
1730
- this.addValue = (text) => {
1731
- return this.valueRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toString().toLowerCase().replace(/\s/g, "-")}-value`).style("font-size", "1em").style("text-align", "center").style("vertical-align", "middle").text(text);
1732
- };
1733
- this.type = "infoBar";
1734
- this.app = opts.app;
1735
- this.hic = opts.hic;
1736
- const table = opts.infoBarDiv;
1737
- this.labelRow = table.append("tr");
1738
- this.valueRow = table.append("tr");
1739
- this.parent = opts.parent;
1740
- }
1741
- async render() {
1742
- this.addLabel("Version");
1743
- this.addValue(this.hic.version);
1744
- this.addLabel("Enzyme");
1745
- this.addValue(this.hic.enzyme || "N/A");
1746
- this.addLabel("Resolution");
1747
- this.resolutionDiv = this.addValue("");
1748
- this.colorScaleLabel = this.addLabel("Scale");
1749
- this.colorScaleDiv = this.valueRow.append("td").attr("data-testid", "sjpp-hic-color-scale");
1750
- const min = this.parent("min");
1751
- let max = this.parent("max");
1752
- if (min == max) max = max + 0.01;
1753
- this.colorScale = new ColorScale({
1754
- barheight: 20,
1755
- barwidth: 100,
1756
- domain: [min, max],
1757
- fontSize: 12,
1758
- height: 40,
1759
- width: 150,
1760
- holder: this.colorScaleDiv,
1761
- colors: [this.startColor, this.endColor],
1762
- position: "20,0",
1763
- ticks: 3,
1764
- tickSize: 5,
1765
- //Do not use min value here on initialization. It's 0 and will not update later.
1766
- markedValue: 1
1767
- });
1768
- }
1769
- update() {
1770
- const res = this.parent("calcResolution");
1771
- let resolutionText;
1772
- if (res < this.hic.bpresolution[this.hic.bpresolution.length - 1]) {
1773
- resolutionText = `${res} fragment${res > 1 ? "s" : ""}`;
1774
- } else {
1775
- resolutionText = bplen(res);
1776
- }
1777
- this.resolutionDiv.text(resolutionText);
1778
- if (this.parent("state").currView == "horizontal") {
1779
- this.colorScaleLabel.style("display", "none");
1780
- this.colorScaleDiv.style("display", "none");
1781
- } else {
1782
- this.colorScaleLabel.style("display", "");
1783
- this.colorScaleDiv.style("display", "");
1784
- const min = this.parent("min");
1785
- const max = this.parent("max");
1786
- if (min < 0) {
1787
- this.colorScale.colors = ["blue", "white", "red"];
1788
- this.colorScale.domain = [min, 0, max];
1789
- } else {
1790
- this.colorScale.colors = ["white", "red"];
1791
- this.colorScale.domain = [0, max];
1792
- }
1793
- this.colorScale.markedValue = min;
1794
- this.colorScale.updateScale();
1795
- }
1796
- }
1797
- };
1798
-
1799
- // tracks/hic/data/DataMapper.ts
1800
- var DataMapper = class {
1801
- constructor(hic, percentile) {
1802
- this.hic = hic;
1803
- this.percentile = percentile ? percentile / 100 : 0.99;
1804
- }
1805
- sortData(data) {
1806
- const vlst = [];
1807
- if (data?.items && data?.items.length) {
1808
- for (const i of data.items) {
1809
- vlst.push(i[2]);
1810
- }
1811
- } else {
1812
- const blankChrs = /* @__PURE__ */ new Set();
1813
- for (const d of data) {
1814
- if (d.lead == "chrM" && !d.items.length || d.lead == "chrY" && !d.items.length) {
1815
- blankChrs.add(d.lead);
1816
- continue;
1817
- }
1818
- for (const i of d.items) {
1819
- vlst.push(i[2]);
1820
- }
1821
- }
1822
- if (blankChrs.size) {
1823
- for (const c of blankChrs) {
1824
- const idx = this.hic.chrlst.indexOf(c);
1825
- this.hic.chrlst.splice(idx, 1);
1826
- }
1827
- }
1828
- }
1829
- const sortedVlst = vlst.sort((a, b) => a - b);
1830
- const max = sortedVlst[Math.floor(sortedVlst.length * this.percentile)];
1831
- const min = sortedVlst[0];
1832
- return [min, max, sortedVlst[sortedVlst.length - 1]];
1833
- }
1834
- };
1835
-
1836
- // tracks/hic/data/GenomeDataFetcher.ts
1837
- var GenomeDataFetcher = class {
1838
- constructor(hic, debugmode, errList = []) {
1839
- this.data = [];
1840
- this.hic = hic;
1841
- this.debugmode = debugmode;
1842
- this.errList = errList || [];
1843
- }
1844
- async getData(obj) {
1845
- if (this.data.length) this.data = [];
1846
- if (!obj?.matrixType) obj.matrixType = "observed";
1847
- try {
1848
- const res = await dofetch3("hicgenome?", {
1849
- method: "POST",
1850
- body: JSON.stringify({
1851
- chrlst: this.hic.chrlst,
1852
- nmeth: obj.nmeth,
1853
- resolution: obj.resolution,
1854
- matrixType: obj.matrixType,
1855
- file: this.hic.file,
1856
- url: this.hic.url,
1857
- nochr: this.hic.nochr
1858
- })
1859
- });
1860
- if (res.error) {
1861
- const errs = res.error.split("\n");
1862
- for (const e of errs) {
1863
- this.errList.push(e);
1864
- }
1865
- }
1866
- return res.data;
1867
- } catch (e) {
1868
- this.errList.push(e.message || e);
1869
- if (e.stack) console.error(e.stack);
1870
- }
1871
- }
1872
- };
1873
-
1874
- // tracks/hic/data/DataFetcher.ts
1875
- var DataFetcher = class {
1876
- constructor(hic, debugmode, errList = []) {
1877
- this.hic = hic;
1878
- this.debugmode = debugmode;
1879
- this.errList = errList || [];
1880
- }
1881
- async getData(obj) {
1882
- if (!obj?.matrixType) obj.matrixType = "observed";
1883
- const arg = {
1884
- matrixType: obj.matrixType,
1885
- file: this.hic.file,
1886
- url: this.hic.url,
1887
- pos1: this.hic.nochr ? obj.lead.replace("chr", "") : obj.lead,
1888
- pos2: this.hic.nochr ? obj.follow.replace("chr", "") : obj.follow,
1889
- nmeth: obj.nmeth,
1890
- resolution: obj.resolution
1891
- };
1892
- try {
1893
- const data = await dofetch3("hicdata?", {
1894
- method: "POST",
1895
- body: JSON.stringify(arg)
1896
- });
1897
- if (data.error) {
1898
- throw Error(`${obj.lead} - ${obj.follow}: ${data.error.error}`);
1899
- }
1900
- if (!data.items || data.items.length == 0) return;
1901
- return data;
1902
- } catch (e) {
1903
- this.errList.push(e.message || e);
1904
- if (e.stack) console.error(e.stack);
1905
- }
1906
- }
1907
- };
1908
-
1909
- // tracks/hic/HicComponent.ts
1910
- var HicComponent = class _HicComponent {
1911
- constructor(opts) {
1912
- this.genomeData = [];
1913
- this.calcResolution = null;
1914
- this.firstRender = true;
1915
- this.min = 0;
1916
- this.absMin = 0;
1917
- this.max = 0;
1918
- this.absMax = 0;
1919
- this.hasStatePreMain = true;
1920
- this.type = _HicComponent.type;
1921
- this.hic = opts.hic;
1922
- this.state = opts.state;
1923
- this.dom = opts.dom;
1924
- this.errList = opts.errList;
1925
- this.plotDiv = this.dom.plotDiv.append("table").classed("sjpp-hic-plot-main", true);
1926
- const tr1 = this.plotDiv.append("tr");
1927
- const tr2 = this.plotDiv.append("tr");
1928
- this.plotDiv = {
1929
- plot: tr1.append("td").classed("sjpp-hic-plot", true).attr("data-testid", "sjpp-hic-plot"),
1930
- yAxis: tr1.append("td").classed("sjpp-hic-plot-yaxis", true).attr("data-testid", "sjpp-hic-yaxis"),
1931
- xAxis: tr2.append("td").classed("sjpp-hic-plot-xaxis", true).attr("data-testid", "sjpp-hic-xaxis"),
1932
- blank: tr2.append("td")
1933
- };
1934
- this.app = opts.app;
1935
- this.dataMapper = new DataMapper(this.hic, opts.state.maxCutoffPercentile);
1936
- this.activeView = this.state.currView;
1937
- this.error = opts.error;
1938
- this.resolution = new Resolution(this.error);
1939
- this.parent = (prop) => {
1940
- return this[prop];
1941
- };
1942
- this.detailDataMapper = new DetailDataMapper(this.hic, this.errList, this.parent);
1943
- }
1944
- static {
1945
- this.type = "view";
1946
- }
1947
- getState(appState) {
1948
- return appState;
1949
- }
1950
- reactsTo(action) {
1951
- if (action.type.startsWith("view")) return true;
1952
- else return false;
1953
- }
1954
- initView() {
1955
- const opts = {
1956
- plotDiv: this.plotDiv,
1957
- hic: this.hic,
1958
- app: this.app,
1959
- parent: (prop) => {
1960
- return this[prop];
1961
- }
1962
- };
1963
- if (this.state.currView == "genome") {
1964
- opts["data"] = this.data;
1965
- this.genome = new GenomeView(opts);
1966
- this.genome.render();
1967
- } else if (this.state.currView === "chrpair") {
1968
- opts["items"] = this.data;
1969
- this.chrpair = new ChrPairView(opts);
1970
- this.chrpair.render();
1971
- } else if (this.state.currView === "detail") {
1972
- opts["data"] = this.data;
1973
- this.detail = new DetailView(opts);
1974
- this.detail.render();
1975
- } else if (this.state.currView === "horizontal") {
1976
- this.horizontal = new HorizontalView(opts);
1977
- this.horizontal.render();
1978
- } else {
1979
- throw Error(`Unknown view: ${this.state.currView}`);
1980
- }
1981
- }
1982
- async fetchData(obj) {
1983
- if (this.data?.length) this.data = [];
1984
- if (this.state.currView == "genome") {
1985
- if (this.activeView != "genome" && this.genomeData?.length) this.data = this.genomeData;
1986
- else {
1987
- const genomeFetcher = new GenomeDataFetcher(this.hic, true, this.errList);
1988
- this.genomeData = await genomeFetcher.getData(obj);
1989
- this.data = this.genomeData;
1990
- }
1991
- } else if (this.state.currView == "detail") {
1992
- this.data = await this.detailDataMapper.getData(this.state.x, this.state.y, this.fragData);
1993
- } else {
1994
- if (!this.state?.x?.chr || !this.state?.y?.chr) {
1995
- this.errList.push(`No positions provided for ${this.activeView} view.`);
1996
- return;
1997
- } else {
1998
- const chrx = this.state.x;
1999
- const chry = this.state.y;
2000
- obj["lead"] = `${chrx.start && chrx.stop ? `${chrx.chr}:${chrx.start}-${chrx.stop}` : chrx.chr}`;
2001
- obj["follow"] = `${chry.start && chry.stop ? `${chry.chr}:${chry.start}-${chry.stop}` : chry.chr}`;
2002
- }
2003
- const dataFetcher = new DataFetcher(this.hic, true, this.errList);
2004
- this.data = await dataFetcher.getData(obj);
2005
- }
2006
- }
2007
- async setResolution(appState) {
2008
- const state = this.app.getState(appState);
2009
- this.calcResolution = this.resolution.getResolution(state, this.hic);
2010
- if (state.currView == "detail" && this.calcResolution == null) {
2011
- await this.detailDataMapper.getFragData(state.x, state.y);
2012
- this.fragData = this.detailDataMapper.frag;
2013
- const maxFragSpan = Math.min(
2014
- this.fragData.x.stop - this.fragData.x.start,
2015
- this.fragData.y.stop - this.fragData.y.start
2016
- );
2017
- this.calcResolution = this.resolution.findResFromArray(
2018
- maxFragSpan,
2019
- state.minFragSpan,
2020
- this.hic.fragresolution,
2021
- true
2022
- );
2023
- } else {
2024
- this.fragData = null;
2025
- }
2026
- return this.calcResolution;
2027
- }
2028
- async setDataArgs(appState) {
2029
- const state = this.app.getState(appState);
2030
- const currView = state[state.currView];
2031
- const args = {
2032
- nmeth: currView.nmeth,
2033
- resolution: await this.setResolution(appState),
2034
- matrixType: currView.matrixType
2035
- };
2036
- if (state.currView == "chrpair") {
2037
- args["lead"] = state.x.chr;
2038
- args["follow"] = state.y.chr;
2039
- }
2040
- return args;
2041
- }
2042
- async getViewData(appState) {
2043
- const args = await this.setDataArgs(appState);
2044
- await this.fetchData(args);
2045
- if (this.data?.length > 0 || this.data?.items?.length > 0) {
2046
- const [min, max, absMax] = this.dataMapper.sortData(this.data);
2047
- this.min = this.absMin = min;
2048
- this.max = max;
2049
- this.absMax = absMax;
2050
- } else {
2051
- if (this.state.currView != "genome") {
2052
- const state = this.app.getState(appState);
2053
- const xPosMessage = state.x?.start ? `${state.x.chr}:${state.x.start}-${state.x.stop}` : state.x.chr;
2054
- const yPosMessage = state.y?.start ? `${state.y.chr}:${state.y.start}-${state.y.stop}` : state.y.chr;
2055
- this.errList.push(`No data returned for ${xPosMessage} and ${yPosMessage}`);
2056
- }
2057
- }
2058
- }
2059
- async init() {
2060
- this.components = {
2061
- controls: await controlPanelInit({
2062
- app: this.app,
2063
- controlsDiv: this.dom.controlsDiv,
2064
- hic: this.hic,
2065
- parent: (prop, value) => {
2066
- if (value) this[prop] = value;
2067
- return this[prop];
2068
- },
2069
- error: this.error.bind(this)
2070
- })
2071
- };
2072
- this.infoBar = new InfoBar({
2073
- app: this.app,
2074
- infoBarDiv: this.dom.infoBarDiv.append("table").style("border-spacing", "3px"),
2075
- hic: this.hic,
2076
- parent: (prop) => {
2077
- return this[prop];
2078
- }
2079
- });
2080
- this.infoBar.render();
2081
- }
2082
- async main(appState) {
2083
- if (this.errList.length) {
2084
- this.app.dispatch({ type: "loading_active", active: false });
2085
- return;
2086
- }
2087
- const state = this.app.getState(appState);
2088
- if (this.firstRender == true) {
2089
- this.firstRender = false;
2090
- await this.getViewData(appState);
2091
- this.initView();
2092
- } else {
2093
- if (state.currView != "horizontal") {
2094
- this.app.dispatch({ type: "loading_active", active: true });
2095
- await this.getViewData(appState);
2096
- }
2097
- if (this.activeView != state.currView) {
2098
- if (this.activeView == "genome") {
2099
- this.genome.svg.remove();
2100
- } else {
2101
- this.plotDiv.xAxis.selectAll("*").remove();
2102
- this.plotDiv.yAxis.selectAll("*").remove();
2103
- this.plotDiv.plot.selectAll("*").remove();
2104
- }
2105
- this.activeView = state.currView;
2106
- this.initView();
2107
- } else {
2108
- this[state.currView].update(this.data);
2109
- }
2110
- }
2111
- this.infoBar.update();
2112
- if (this.errList.length) {
2113
- this.error(this.errList);
2114
- this.app.dispatch({ type: "loading_active", active: false });
2115
- }
2116
- }
2117
- };
2118
- var viewCompInit = getCompInit(HicComponent);
2119
-
2120
- // tracks/hic/HicApp.ts
2121
- var HicApp = class _HicApp extends AppBase {
2122
- constructor(opts) {
2123
- super(opts);
2124
- this.views = ["genome", "chrpair", "detail", "horizontal"];
2125
- this.errList = [];
2126
- /** Required for rx but not in use */
2127
- this.wasDestroyed = false;
2128
- this.type = _HicApp.type;
2129
- this.hic = {
2130
- enzyme: opts.enzyme,
2131
- file: opts.file,
2132
- url: opts.url,
2133
- genome: opts.genome,
2134
- holder: opts.holder,
2135
- hostUrl: opts.hostUrl,
2136
- jwt: opts.jwt,
2137
- position1: opts.position1,
2138
- position2: opts.position2,
2139
- maxCutoffPercentile: opts.maxCutoffPercentile,
2140
- name: "name" in opts ? opts.name : "Hi-C",
2141
- tklist: "tklst" in opts ? opts.tklst : [],
2142
- state: "state" in opts ? opts.state : {}
2143
- };
2144
- this.dom = {
2145
- errorDiv: opts.holder.append("div").classed("sjpp-hic-error", true),
2146
- controlsDiv: opts.holder.append("div").classed("sjpp-hic-controls", true).style("display", "inline-block"),
2147
- infoBarDiv: opts.holder.append("div").classed("sjpp-hic-infobar", true).style("display", "inline-block").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc"),
2148
- loadingDiv: select_default("body").append("div").attr("id", "sjpp-loading-overlay"),
2149
- plotDiv: opts.holder.append("div").classed("sjpp-hic-main", true).style("display", "inline-block"),
2150
- tip: new Menu()
2151
- };
2152
- }
2153
- static {
2154
- this.type = "app";
2155
- }
2156
- async error(err) {
2157
- if (err && typeof err == "string") this.errList.push(err);
2158
- showErrorsWithCounter(this.errList, this.dom.errorDiv);
2159
- this.errList = [];
2160
- }
2161
- determineView() {
2162
- if (!this.hic.position1 && !this.hic.position2 && !this.hic.state.currView) this.hic.state.currView = "genome";
2163
- if (!this.hic.position1 && this.hic.position2) this.errList.push("Missing first position");
2164
- if (this.hic.position1 && !this.hic.position2) this.errList.push("Missing second position");
2165
- if (this.hic.position1 && this.hic.position2) {
2166
- const pos1 = this.hic.position1.split(/[:-]/);
2167
- const pos2 = this.hic.position2.split(/[:-]/);
2168
- this.hic.state.x = { chr: pos1[0] };
2169
- this.hic.state.y = { chr: pos2[0] };
2170
- if (!Number.isNaN(+pos1[1]) && !Number.isNaN(+pos1[2])) {
2171
- this.hic.state.x.start = +pos1[1];
2172
- this.hic.state.x.stop = +pos1[2];
2173
- this.hic.state.y.start = +pos2[1];
2174
- this.hic.state.y.stop = +pos2[2];
2175
- this.hic.state.currView = "detail";
2176
- } else {
2177
- this.hic.state.currView = "chrpair";
2178
- }
2179
- } else {
2180
- if (!this.views.some((v) => v === this.hic.state.currView)) this.error(`Unknown view: ${this.hic.state.currView}`);
2181
- else return this.hic.state.currView;
2182
- }
2183
- }
2184
- getViewsConfig() {
2185
- if (this.hic.maxCutoffPercentile) this.hic.state.maxCutoffPercentile = this.hic.maxCutoffPercentile;
2186
- let nmeth;
2187
- if (this.hic["normalization"]?.length > 0) {
2188
- if (!this.hic["normalization"].includes("NONE")) this.hic["normalization"].unshift("NONE");
2189
- nmeth = this.hic["normalization"][0];
2190
- } else {
2191
- nmeth = "NONE";
2192
- }
2193
- if (this.hic.state.currView) {
2194
- if (!this.hic.state[this.hic.state.currView]) this.hic.state[this.hic.state.currView] = {};
2195
- if (!this.hic.state[this.hic.state.currView]?.matrixType) {
2196
- this.hic.state[this.hic.state.currView].matrixType = "observed";
2197
- }
2198
- if (!this.hic.state[this.hic.state.currView]?.nmeth) {
2199
- this.hic.state[this.hic.state.currView].nmeth = nmeth;
2200
- }
2201
- }
2202
- for (const v of this.views) {
2203
- if (!this.hic.state[v]) {
2204
- this.hic.state[v] = {
2205
- matrixType: "observed",
2206
- nmeth
2207
- };
2208
- }
2209
- }
2210
- }
2211
- async init() {
2212
- this.determineView();
2213
- try {
2214
- await hicParseFile(this.hic, true, this.errList);
2215
- this.getViewsConfig();
2216
- this.store = await hicStoreInit({ app: this.api, state: this.hic.state });
2217
- this.state = await this.store.copyState();
2218
- this.components = {
2219
- loadingOverlay: await loadingInit({
2220
- app: this.api,
2221
- loadingDiv: this.dom.loadingDiv
2222
- }),
2223
- view: await viewCompInit({
2224
- app: this.api,
2225
- state: this.state,
2226
- dom: this.dom,
2227
- hic: this.hic,
2228
- errList: this.errList,
2229
- error: this.error
2230
- })
2231
- };
2232
- await this.api.dispatch();
2233
- } catch (e) {
2234
- console.error(e.stack || e);
2235
- }
2236
- }
2237
- main() {
2238
- if (this.errList.length) {
2239
- this.error(this.errList);
2240
- this.dom.loadingDiv.style("display", "none");
2241
- return;
2242
- }
2243
- }
2244
- };
2245
- var hicInit = getAppInit(HicApp);
2246
- export {
2247
- hicInit
2248
- };
2249
- //# sourceMappingURL=HicApp-IDH2A4BC.js.map