@sjcrh/proteinpaint-client 2.182.1 → 2.183.1

package/dist/DE-F7LUSAO2.js

@@ -0,0 +1,93 @@
+import {
+  appInit
+} from "./chunk-IQ25XHGX.js";
+import "./chunk-OKIJIYSP.js";
+import "./chunk-SKMFMGCD.js";
+import "./chunk-QTGTMFHM.js";
+import "./chunk-QDRZL47L.js";
+import "./chunk-ILDUYXV5.js";
+import "./chunk-FWKAYZ55.js";
+import "./chunk-KZFOWI7N.js";
+import "./chunk-7N3Q25KC.js";
+import "./chunk-54P7H5GL.js";
+import "./chunk-HZETQJGD.js";
+import "./chunk-PRZWSBMA.js";
+import "./chunk-2LCTMDCS.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-E5JQ3PN6.js";
+import "./chunk-RCYTUKAJ.js";
+import "./chunk-A6TQGNDQ.js";
+import "./chunk-HYZG6OPC.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-LSEFWW72.js";
+import "./chunk-5EF5U7MX.js";
+import "./chunk-IQIXGTQV.js";
+import "./chunk-UCLS2SVB.js";
+import "./chunk-MVTCBVSX.js";
+import "./chunk-F6V4AYWP.js";
+import "./chunk-5OHXYXLD.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-JOT4WDJE.js";
+import "./chunk-OTCYJP7G.js";
+import "./chunk-GXINX3WK.js";
+import "./chunk-SOED2SLH.js";
+import "./chunk-XRVBHNCW.js";
+import "./chunk-BEWDIM6H.js";
+import "./chunk-IH7ILDJS.js";
+import "./chunk-LOZEKOES.js";
+import "./chunk-TOU7EVFQ.js";
+import "./chunk-OAWQ6LOO.js";
+import "./chunk-SEEYV6P2.js";
+import "./chunk-NDWTN4U5.js";
+import "./chunk-OMR2DT66.js";
+import "./chunk-HFNDKYVF.js";
+
+// gdc/DE.ts
+async function init(arg, holder, genomes) {
+  const useGenome = arg.genome || "hg38";
+  const useDslabel = arg.dslabel || "GDC";
+  const genome = genomes[useGenome];
+  const massApi = await appInit({
+    //debug: arg.debugmode, // is debug accepted?
+    genome,
+    holder,
+    state: {
+      genome: useGenome,
+      dslabel: useDslabel,
+      termfilter: { filter0: arg.filter0 },
+      nav: { activeTab: 1, header_mode: "hidden" },
+      plots: [{ chartType: "DEinput" }]
+    },
+    opts: Object.assign(
+      {
+        // todo additional customizations
+        // dictionary:{header:'Select a variable to build Correlation Plot'}
+        // some way to make gene exp violin/boxplot to use log scale by default, but numeric dict term should not
+      },
+      arg.opts || {}
+    ),
+    app: arg.opts?.app || {}
+  });
+  const api = {
+    update: async (updateArg) => {
+      if (!massApi) return;
+      if ("filter0" in updateArg) {
+        massApi.dispatch({
+          type: "app_refresh",
+          subactions: [
+            {
+              type: "filter_replace",
+              filter0: updateArg.filter0
+            }
+          ]
+        });
+      }
+    },
+    triggerAbort: (reason = "") => massApi.triggerAbort(reason)
+  };
+  return api;
+}
+export {
+  init
+};
+//# sourceMappingURL=DE-F7LUSAO2.js.map

package/dist/DEinput-V7MF5IEZ.js

@@ -0,0 +1,297 @@
+import {
+  PlotBase,
+  excludeFilterByTag,
+  filterInit,
+  filterJoin,
+  filterPromptInit,
+  getNormalRoot,
+  negateFilter,
+  renderPreAnalysisData,
+  renderTable
+} from "./chunk-2LCTMDCS.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-E5JQ3PN6.js";
+import {
+  dofetch3
+} from "./chunk-RCYTUKAJ.js";
+import "./chunk-A6TQGNDQ.js";
+import "./chunk-HYZG6OPC.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-LSEFWW72.js";
+import "./chunk-5EF5U7MX.js";
+import "./chunk-IQIXGTQV.js";
+import "./chunk-UCLS2SVB.js";
+import {
+  copyMerge,
+  getCompInit
+} from "./chunk-MVTCBVSX.js";
+import "./chunk-F6V4AYWP.js";
+import "./chunk-5OHXYXLD.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-JOT4WDJE.js";
+import "./chunk-OTCYJP7G.js";
+import "./chunk-GXINX3WK.js";
+import "./chunk-SOED2SLH.js";
+import {
+  getColors
+} from "./chunk-XRVBHNCW.js";
+import "./chunk-BEWDIM6H.js";
+import "./chunk-IH7ILDJS.js";
+import "./chunk-LOZEKOES.js";
+import "./chunk-TOU7EVFQ.js";
+import "./chunk-OAWQ6LOO.js";
+import "./chunk-SEEYV6P2.js";
+import "./chunk-NDWTN4U5.js";
+import {
+  rgb
+} from "./chunk-OMR2DT66.js";
+import "./chunk-HFNDKYVF.js";
+
+// plots/DEinput.ts
+var colorScale = getColors(5);
+var DEinputPlot = class _DEinputPlot extends PlotBase {
+  constructor(opts, api) {
+    super(opts, api);
+    this.components = {};
+    this.type = _DEinputPlot.type;
+    this.opts = opts;
+    this.dom = this.getDom();
+    this.groups = [];
+  }
+  static {
+    this.type = "DEinput";
+  }
+  getDom() {
+    const header = this.opts.header.html("Differential Gene Expression");
+    const holder = this.opts.holder.append("div").style("margin", "10px");
+    const table = holder.append("div");
+    const btns = holder.append("div").style("margin-top", "5px");
+    const addGroup = btns.append("div").style("display", "inline-block");
+    const submit = btns.append("div").style("display", "none").style("margin-left", "15px").attr("class", "sja_new_filter_btn sja_menuoption");
+    const loading = holder.append("div").style("display", "none").style("margin", "20px 10px").text("Loading...");
+    const preAnalysis = holder.append("div").style("display", "none").style("margin-top", "20px").style("margin-left", "5px");
+    const dom = { header, table, addGroup, submit, loading, preAnalysis };
+    return dom;
+  }
+  getState(appState) {
+    const config = appState.plots.find((p) => p.id === this.id);
+    if (!config) {
+      throw `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`;
+    }
+    return {
+      termfilter: appState.termfilter,
+      config,
+      // quick fix to skip history tracking as needed
+      _scope_: appState._scope_
+    };
+  }
+  async init() {
+  }
+  // TODO: handle errors
+  async main() {
+    this.dom.preAnalysis.selectAll("*").remove();
+    this.makeGroupsUI();
+    this.mayRenderSubmit();
+  }
+  async makeGroupsUI() {
+    if (!this.filterPrompt) {
+      this.filterPrompt = await filterPromptInit({
+        holder: this.dom.addGroup,
+        vocabApi: this.app.vocabApi,
+        emptyLabel: "Add group",
+        header_mode: "hide_search",
+        callback: async (f) => {
+          const filter2 = getNormalRoot(f);
+          this.addNewGroup(filter2, this.groups);
+          await this.main();
+        },
+        debug: this.opts.debug
+      });
+    }
+    const filter = structuredClone(this.state.termfilter.filter);
+    this.filterPrompt.main(excludeFilterByTag(filter, "cohortFilter"));
+    if (!this.groups.length) {
+      this.dom.table.style("display", "none");
+      return;
+    }
+    this.dom.table.style("display", "block").selectAll("*").remove();
+    const tableArg = {
+      div: this.dom.table,
+      columns: [
+        {},
+        // blank column to add delete buttons
+        {
+          label: "NAME",
+          editCallback: async (i, cell) => {
+            const newName = cell.value;
+            const index = this.groups.findIndex((group) => group.name == newName);
+            if (index != -1) {
+              alert(`Group named ${newName} already exists`);
+              await this.main();
+            } else {
+              this.groups[i].name = newName;
+              await this.main();
+            }
+          }
+        },
+        {
+          label: "COLOR",
+          editCallback: async (i, cell) => {
+            this.groups[i].color = cell.color;
+            this.main();
+          }
+        },
+        //{ label: '#SAMPLE' }, // will re-enable when filtered sample count can be supported for gdc
+        { label: "FILTER" }
+      ],
+      rows: [],
+      striped: false,
+      // no alternating row bg color so delete button appears more visible
+      showLines: false
+    };
+    for (const g of this.groups) {
+      tableArg.rows.push([
+        {},
+        // blank cell to add delete button
+        { value: g.name },
+        // to allow click to show <input>
+        { color: g.color },
+        // { value: 'n=' + (await self.vocabApi.getFilteredSampleCount(g.filter)) }, // will re-enable when filtered sample count can be supported for gdc
+        {}
+        // blank cell to show filter ui
+      ]);
+    }
+    renderTable(tableArg);
+    for (const [i, row] of tableArg.rows.entries()) {
+      row[0].__td.append("div").attr("class", "sja_menuoption").style("padding", "1px 6px").html("&times;").on("click", () => {
+        this.groups.splice(i, 1);
+        this.main();
+      });
+      const group = this.groups[i];
+      filterInit({
+        holder: row[3].__td,
+        vocabApi: this.app.vocabApi,
+        header_mode: "hide_search",
+        callback: (f) => {
+          if (!f || f.lst.length == 0) {
+            const i2 = this.groups.findIndex((g) => g.name == group.name);
+            this.groups.splice(i2, 1);
+          } else {
+            group.filter = f;
+          }
+          this.main();
+        }
+      }).main(group.filter);
+    }
+    this.dom.addGroup.select(".sja_new_filter_btn").style("pointer-events", "auto").style("opacity", 1);
+  }
+  addNewGroup(filter, groups, name) {
+    if (!groups) throw "groups is missing";
+    if (!name) {
+      const base = "New group";
+      name = base;
+      for (let i = 0; ; i++) {
+        name = base + (i === 0 ? "" : " " + i);
+        if (!groups.find((g) => g.name === name)) break;
+      }
+    }
+    const newGroup = {
+      name,
+      filter,
+      color: rgb(colorScale(groups.length)).formatHex()
+    };
+    groups.push(newGroup);
+  }
+  mayRenderSubmit() {
+    if (!this.groups.length) {
+      this.dom.submit.style("display", "none");
+      return;
+    }
+    this.dom.submit.style("display", "inline-block");
+    if (this.groups.length == 1) {
+      this.dom.submit.text(`Submit (${this.groups[0].name} vs others)`);
+      this.dom.submit.on("click", async () => {
+        const groups = [this.groups[0]];
+        const otherGroup = {
+          name: "Not in " + groups[0].name,
+          color: "#ccc",
+          filter: negateFilter(groups[0].filter)
+        };
+        groups.push(otherGroup);
+        await this.clickSubmit(groups);
+      });
+    } else if (this.groups.length == 2) {
+      this.dom.addGroup.select(".sja_new_filter_btn").style("pointer-events", "none").style("opacity", 0.5);
+      this.dom.submit.text(`Submit (${this.groups[0].name} vs ${this.groups[1].name})`);
+      this.dom.submit.on("click", async () => {
+        await this.clickSubmit(this.groups);
+      });
+    } else {
+      throw new Error("cannot exceed 2 groups");
+    }
+  }
+  async clickSubmit(groups) {
+    this.dom.loading.style("display", "block");
+    const samplelstTW = {
+      q: { groups: [] },
+      term: {
+        name: groups.map((g) => g.name).join(" vs "),
+        type: "samplelst",
+        values: {}
+      }
+    };
+    for (const g of groups) {
+      const samples = await this.app.vocabApi.getFilteredSampleList(
+        filterJoin([g.filter, this.state.termfilter.filter])
+      );
+      const sampleIds = samples.map((s) => {
+        return { sampleId: s };
+      });
+      samplelstTW.q.groups.push({
+        name: g.name,
+        in: true,
+        values: sampleIds
+      });
+      samplelstTW.term.values[g.name] = {
+        color: g.color,
+        key: g.name,
+        label: g.name,
+        list: sampleIds
+      };
+    }
+    const body = {
+      genome: this.app.vocabApi.vocab.genome,
+      dslabel: this.app.vocabApi.vocab.dslabel,
+      samplelst: { groups: samplelstTW.q.groups },
+      filter: this.state.termfilter.filter,
+      filter0: this.state.termfilter.filter0,
+      preAnalysis: true
+    };
+    const preAnalysisData = await dofetch3("termdb/DE", { body });
+    this.dom.loading.style("display", "none");
+    this.dom.preAnalysis.style("display", "block");
+    this.dom.preAnalysis.append("div").style("font-weight", "bold").text("Samples with gene expression data:");
+    renderPreAnalysisData({
+      preAnalysisData,
+      samplelstTW,
+      groups: samplelstTW.q.groups,
+      holder: this.dom.preAnalysis,
+      self: this
+    });
+  }
+};
+var DEinputInit = getCompInit(DEinputPlot);
+var componentInit = DEinputInit;
+async function getPlotConfig(opts) {
+  const config = {
+    chartType: "DEinput",
+    settings: {}
+  };
+  return copyMerge(config, opts);
+}
+export {
+  DEinputInit,
+  componentInit,
+  getPlotConfig
+};
+//# sourceMappingURL=DEinput-V7MF5IEZ.js.map

package/dist/DifferentialAnalysis-R2Z7G75Y.js

@@ -0,0 +1,238 @@
+import {
+  getDefaultGseaSettings
+} from "./chunk-MZ7RBJSI.js";
+import "./chunk-H55L2FAY.js";
+import {
+  PlotBase,
+  Tabs,
+  getDefaultVolcanoSettings,
+  validateVolcanoSettings
+} from "./chunk-2LCTMDCS.js";
+import "./chunk-HJ6L54YS.js";
+import {
+  importPlot
+} from "./chunk-E5JQ3PN6.js";
+import "./chunk-RCYTUKAJ.js";
+import {
+  Menu
+} from "./chunk-A6TQGNDQ.js";
+import "./chunk-HYZG6OPC.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-LSEFWW72.js";
+import "./chunk-5EF5U7MX.js";
+import "./chunk-IQIXGTQV.js";
+import "./chunk-UCLS2SVB.js";
+import {
+  copyMerge,
+  getCompInit
+} from "./chunk-MVTCBVSX.js";
+import "./chunk-F6V4AYWP.js";
+import "./chunk-5OHXYXLD.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-JOT4WDJE.js";
+import "./chunk-OTCYJP7G.js";
+import "./chunk-GXINX3WK.js";
+import {
+  DNA_METHYLATION,
+  GENE_EXPRESSION,
+  SINGLECELL_CELLTYPE,
+  termType2label
+} from "./chunk-SOED2SLH.js";
+import "./chunk-XRVBHNCW.js";
+import "./chunk-BEWDIM6H.js";
+import "./chunk-IH7ILDJS.js";
+import "./chunk-LOZEKOES.js";
+import "./chunk-TOU7EVFQ.js";
+import "./chunk-OAWQ6LOO.js";
+import "./chunk-SEEYV6P2.js";
+import "./chunk-NDWTN4U5.js";
+import "./chunk-OMR2DT66.js";
+import "./chunk-HFNDKYVF.js";
+
+// plots/diffAnalysis/view/DiffAnalysisView.ts
+var DiffAnalysisView = class {
+  constructor(app, config, dom) {
+    this.app = app;
+    this.config = config;
+    this.dom = dom;
+    setRenderers(this);
+    this.tabsData = this.getTabsOptions(this);
+    this.tabs = new Tabs({ holder: this.dom.tabsDiv, tabs: this.tabsData });
+    this.tabs.main();
+  }
+  update(plotConfig) {
+    const activeTabIndex = this.tabsData.findIndex((tab) => tab.id == plotConfig.childType);
+    this.tabs.update(activeTabIndex);
+  }
+};
+function setRenderers(self) {
+  self.getTabsOptions = (self2) => {
+    const tabs = [
+      {
+        active: self2.config.childType === "volcano",
+        id: "volcano",
+        label: "Volcano",
+        isVisible: () => true,
+        // isVisible: () => self.config.termType === TermTypes.GENE_EXPRESSION,
+        getPlotConfig: () => {
+          return {
+            childType: "volcano"
+          };
+        },
+        callback: self2.tabCallback
+      },
+      {
+        active: self2.config.childType === "gsea",
+        id: "gsea",
+        label: "Gene Set Enrichment Analysis",
+        isVisible: () => true,
+        // isVisible: () => self.config.termType === TermTypes.GENE_EXPRESSION,
+        getPlotConfig: () => {
+          return {
+            childType: "gsea"
+          };
+        },
+        callback: self2.tabCallback
+      }
+    ];
+    return tabs;
+  };
+  self.tabCallback = async (event, tab) => {
+    if (!event || !tab || !tab.id) return;
+    const plotConfig = tab.getPlotConfig();
+    await self.app.dispatch({
+      type: "plot_edit",
+      id: self.config.id,
+      config: plotConfig
+    });
+  };
+}
+
+// plots/diffAnalysis/DifferentialAnalysis.ts
+var DifferentialAnalysis = class extends PlotBase {
+  constructor(opts, api) {
+    super(opts, api);
+    this.type = "differentialAnalysis";
+    this.components = {
+      plots: {}
+    };
+    this.termType = opts.termType;
+    const holder = opts.holder.classed("sjpp-diff-analysis-main", true);
+    const controls = opts.controls ? holder : holder.append("div");
+    const div = holder.append("div").style("padding", "5px").style("display", "inline-block").style("vertical-align", "top");
+    const tabsDiv = div.append("div").attr("id", "sjpp-diff-analysis-tabs").style("display", "inline-block");
+    const plots = div.append("div").attr("id", "sjpp-diff-analysis-tabs-content");
+    this.dom = {
+      controls: controls.style("display", "inline-block"),
+      div,
+      tabsDiv,
+      plots,
+      tip: new Menu({ padding: "" })
+    };
+    this.plotsControlsDiv = {};
+    this.plotsDiv = {};
+    if (opts.parentId) this.parentId = opts.parentId;
+    if (opts.header) {
+      this.dom.header = {
+        terms: opts.header.append("span"),
+        title: opts.header.append("span").style("font-size", "0.8em").style("opacity", 0.7)
+      };
+    }
+  }
+  static {
+    this.type = "differentialAnalysis";
+  }
+  getState(appState) {
+    const config = appState.plots.find((p) => p.id === this.id);
+    if (!config) {
+      throw new Error(
+        `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`
+      );
+    }
+    return {
+      config
+    };
+  }
+  reactsTo(action) {
+    if (action.type.includes("cache_termq")) return true;
+    if (action.type.startsWith("plot_")) {
+      return action.id === this.id || action.id == this.parentId;
+    }
+    if (action.type.startsWith("filter")) return true;
+    if (action.type.startsWith("cohort")) return true;
+    if (action.type == "app_refresh") return true;
+  }
+  async init(appState) {
+    const state = this.getState(appState);
+    const config = structuredClone(state.config);
+    this.plotTabs = new DiffAnalysisView(this.app, config, this.dom);
+  }
+  async setComponent(config) {
+    this.plotsControlsDiv[config.childType] = this.dom.controls.append("div");
+    this.plotsDiv[config.childType] = this.dom.plots.append("div");
+    const opts = {
+      app: this.app,
+      holder: this.plotsDiv[config.childType],
+      id: this.id,
+      parent: this.api,
+      controls: this.plotsControlsDiv[config.childType],
+      termType: config.termType
+    };
+    const _ = await importPlot(config.childType, `unsupported childType='${config.childType}'`);
+    this.components.plots[config.childType] = await _.componentInit(opts);
+  }
+  async main() {
+    const config = structuredClone(this.state.config);
+    if (config.chartType != this.type) return;
+    if (!this.components.plots[config.childType]) await this.setComponent(config);
+    for (const childType in this.components.plots) {
+      const chart = this.components.plots[childType];
+      if (chart.type != config.childType) {
+        this.plotsDiv[chart.type].style("display", "none");
+        this.plotsControlsDiv[chart.type].style("display", "none");
+      }
+    }
+    this.plotsDiv[config.childType].style("display", "");
+    this.plotsControlsDiv[config.childType].style("display", "");
+    if (this.dom.header) {
+      if (config.tw) this.dom.header.terms.text(config.tw.term.name);
+      const typeStr = termType2label(config.termType).toUpperCase();
+      this.dom.header.title.text(` DIFFERENTIAL ${typeStr} ANALYSIS`);
+    }
+    if (this.plotTabs) this.plotTabs.update(config);
+  }
+};
+var DiffAnalysisInit = getCompInit(DifferentialAnalysis);
+var componentInit = DiffAnalysisInit;
+var enabledTermTypes = [GENE_EXPRESSION, SINGLECELL_CELLTYPE, DNA_METHYLATION];
+function getPlotConfig(opts) {
+  if (!opts.termType) throw new Error(".termType is required");
+  if (!enabledTermTypes.includes(opts.termType))
+    throw new Error(`termType = '${opts.termType}' not supported by Differential Analysis`);
+  const config = {
+    chartType: "differentialAnalysis",
+    childType: "volcano",
+    termType: opts.termType,
+    settings: {},
+    highlightedData: opts.highlightedData || [],
+    hidePlotFilter: true
+    //TODO: Support filtering and reactivity in child plots
+  };
+  if (opts.termType == SINGLECELL_CELLTYPE) {
+    Object.assign(config, {
+      categoryName: opts.categoryName || "",
+      termId: opts.termId || "",
+      sample: opts.sample || ""
+    });
+  }
+  config.settings.volcano = getDefaultVolcanoSettings(opts.overrides, opts);
+  config.settings.gsea = getDefaultGseaSettings(opts.overrides);
+  validateVolcanoSettings(config, opts);
+  return copyMerge(config, opts);
+}
+export {
+  DiffAnalysisInit,
+  componentInit,
+  getPlotConfig
+};
+//# sourceMappingURL=DifferentialAnalysis-R2Z7G75Y.js.map