@rcsb/rcsb-saguaro-app 4.0.0-groups.13 → 4.0.0-groups.14

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Files changed (3) hide show
  1. package/build/dist/app.js +1 -1
  2. package/build/dist/app.js.map +1 -1
  3. package/package.json +1 -1
package/build/dist/app.js CHANGED
@@ -91,5 +91,5 @@ object-assign
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  *
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  * This source code is licensed under the MIT license found in the
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  * LICENSE file in the root directory of this source tree.
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- */var r,o,a,i;if("object"==typeof performance&&"function"==typeof performance.now){var c=performance;e.unstable_now=function(){return c.now()}}else{var s=Date,l=s.now();e.unstable_now=function(){return s.now()-l}}if("undefined"==typeof window||"function"!=typeof MessageChannel){var u=null,p=null,d=function(){if(null!==u)try{var t=e.unstable_now();u(!0,t),u=null}catch(t){throw setTimeout(d,0),t}};r=function(t){null!==u?setTimeout(r,0,t):(u=t,setTimeout(d,0))},o=function(t,e){p=setTimeout(t,e)},a=function(){clearTimeout(p)},e.unstable_shouldYield=function(){return!1},i=e.unstable_forceFrameRate=function(){}}else{var h=window.setTimeout,f=window.clearTimeout;if("undefined"!=typeof console){var m=window.cancelAnimationFrame;"function"!=typeof window.requestAnimationFrame&&console.error("This browser doesn't support requestAnimationFrame. 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u.SearchRequestProperty;t.requestMembers(Object.assign(Object.assign({},this.props.searchQuery),{query:p.addGroupNodeToSearchQuery(this.props.groupGranularity,this.props.groupId,this.props.searchQuery),return_type:d.ReturnType.PolymerEntity})).then(e=>{this.filterEntities=e,t.requestMembers(Object.assign(Object.assign({},this.props.searchQuery),{query:p.addGroupNodeToSearchQuery(this.props.groupGranularity,this.props.groupId,this.props.searchQuery),return_type:d.ReturnType.PolymerInstance})).then(t=>{this.filterInstances=t,this.onSelect("alignment")})})}else{this.onSelect("alignment"),(new u.SearchRequestProperty).requestMembers({query:p.searchGroupQuery(this.props.groupGranularity,this.props.groupId),return_type:d.ReturnType.PolymerInstance}).then(t=>{this.filterInstances=t,this.onSelect("alignment")})}}onSelect(t){var e,n,r,o;if(!this.rendered.has(t))switch(this.rendered.add(t),t){case"alignment":e=t.toString(),n=this.props.groupGranularity,r=this.props.groupId,o={page:{first:100,after:"0"},alignmentFilter:this.filterEntities},c.RcsbFvGroupBuilder.buildGroupAlignmentFv(e,n,r,s.SequenceReference.PdbEntity,s.SequenceReference.Uniprot,Object.assign(Object.assign({},o),{boardConfig:{rowTitleWidth:190},externalTrackBuilder:S()}));break;case"binding-sites":this.props.searchQuery?g(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"},alignmentFilter:this.filterEntities,filters:[{field:s.FieldName.TargetId,operation:s.OperationType.Equals,values:this.filterInstances}]}):g(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"}});break;case"structural-features":this.props.searchQuery?v(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"},alignmentFilter:this.filterEntities,filters:[{field:s.FieldName.TargetId,operation:s.OperationType.Equals,values:this.filterInstances}]}):v(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"}})}}}e.GroupSequenceTabs=m;function g(t,e,n,r,o){var a;return c.RcsbFvGroupBuilder.buildGroupAnnotationFv(t,e,n,s.SequenceReference.PdbEntity,s.SequenceReference.Uniprot,Object.assign(Object.assign({},o),{boardConfig:{rowTitleWidth:190},filters:[...null!==(a=null==o?void 0:o.filters)&&void 0!==a?a:[],{field:s.FieldName.Type,values:[s.Type.BindingSite],operation:s.OperationType.Equals,source:s.Source.PdbInstance}],sources:[s.Source.PdbInstance],annotationProcessing:b(r),externalTrackBuilder:y()}))}function v(t,e,n,r,o){var a;return c.RcsbFvGroupBuilder.buildGroupAnnotationFv(t,e,n,s.SequenceReference.PdbEntity,s.SequenceReference.Uniprot,Object.assign(Object.assign({},o),{boardConfig:{rowTitleWidth:150},filters:[...null!==(a=null==o?void 0:o.filters)&&void 0!==a?a:[],{field:s.FieldName.Type,values:[s.Type.HelixP,s.Type.Sheet,s.Type.Cath,s.Type.Scop],operation:s.OperationType.Equals,source:s.Source.PdbInstance},{field:s.FieldName.Type,values:[s.Type.Pfam],operation:s.OperationType.Equals,source:s.Source.PdbEntity}],sources:[s.Source.PdbInstance,s.Source.PdbEntity],annotationProcessing:b(r),externalTrackBuilder:S()}))}function b(t){const e=new Map,n=t;return{getAnnotationValue:t=>(e.has(t.type)||e.set(t.type,t.d.value),t.p.values[0]),computeAnnotationValue:t=>{t.forEach((t,r)=>{const o=r.includes(s.Type.Cath)||r.includes(s.Type.Scop)||r.includes(s.Type.BindingSite)?e.get(r):n;t.forEach((t,e)=>{t.value=Math.ceil(1e3*t.value/o)/1e3})})}}}function y(){const t=new Map;let e=0;const n=S();return{addTo(r){r.annotationTracks.unshift({trackId:"annotationTrack_GLOBAL_BINDINGS",trackHeight:40,displayType:"area",trackColor:"#F9F9F9",displayColor:"#c4124b",titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:"GLOBAL BINDINGS",displayDomain:[0,e],interpolationType:"step",trackData:Array.from(t.values())}),n.addTo(r)},processAlignmentAndFeatures(r){r.annotations.forEach(n=>{n.features.forEach(n=>{n.feature_positions.forEach(n=>{n.values.forEach((r,o)=>{const a=(n.beg_seq_id+o).toString();t.has(a)?(t.get(a).value+=r,t.get(a).value>e&&(e=t.get(a).value)):(t.set(a,{begin:n.beg_seq_id+o,type:"GLOBAL BINDINGS",value:r}),0==e&&(e=r))})})})}),n.processAlignmentAndFeatures(r)},filterFeatures:t=>(t.forEach(t=>{t.features=t.features.filter(t=>t.name.includes("ligand"))}),new Promise(e=>{e(t)}))}}function S(){let t=new Array;return{addTo(e){e.alignmentTracks.sequence||(e.alignmentTracks.sequence=[{trackId:"annotationTrack_ALIGNMENT_MODE",displayType:"sequence",trackColor:"#F9F9F9",titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:"ALIGNMENT MODE",nonEmptyDisplay:!0,trackData:t.map((t,e)=>({begin:e+1,value:t.mode(),description:[t.frequency().filter(t=>t.value>=.01).map(t=>t.symbol.replace("-","gap")+": "+Math.trunc(100*t.value)/100).join(", ")]}))},{trackId:"annotationTrack_ALIGNMENT_FREQ",displayType:"multi-area",trackColor:"#F9F9F9",displayColor:{thresholds:[],colors:["#5289e9","#76bbf6","#91cef6","#b9d9f8","#d6eafd","#e6f5fd","#ececec"]},trackHeight:20,titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:"CONSERVATION",trackData:t.map((t,e)=>{const n=t.frequency().filter(t=>"-"!=t.symbol).slice(0,5).map(t=>Math.trunc(100*t.value)/100),r=Math.trunc(100*t.frequency().filter(t=>"-"==t.symbol)[0].value)/100;return{begin:e+1,values:n.map((t,e)=>n.slice(0,e+1).reduce((t,e)=>t+e)).concat([1-r,1]),value:"-"!=t.frequency()[0].symbol?Math.trunc(100*t.frequency()[0].value)/100:0}})}])},processAlignmentAndFeatures(e){!function(e){var n;if(e.alignment_length&&e.alignment_length!=e.alignment_logo.length)throw"ERROR Alignment length and logo should match";null===(n=e.alignment_logo)||void 0===n||n.forEach(e=>{t.push(new f.Logo(e))})}(e.alignments)},filterFeatures:t=>(t.forEach(t=>{t.features=t.features.filter(t=>"automated matches"!=t.name)}),new Promise(e=>{e(t)}))}}},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvGroupBuilder=void 0;const o=n(12),a=n(107),i=n(113);e.RcsbFvGroupBuilder=class{static buildGroupAnnotationFv(t,e,n,i,c,s){return r(this,void 0,void 0,(function*(){return new 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t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return o(e,t),e},i=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvGroupAnnotation=void 0;const c=n(14),s=n(32),l=a(n(51)),u=n(24),p=l;class d extends c.RcsbFvAbstractModule{constructor(t,e,n){super(t,e),this.annotationCollector=new s.AnnotationCollector(p),(null==n?void 0:n.sequenceCollector)?this.sequenceCollector=n.sequenceCollector:this.sequenceCollector=new u.SequenceCollector}protectedBuild(t){var e,n,r,o,a,c,s;return i(this,void 0,void 0,(function*(){this.alignmentTracks=yield this.sequenceCollector.collect({group:t.group,groupId:t.groupId,filter:null===(e=t.additionalConfig)||void 0===e?void 0:e.alignmentFilter,page:null===(n=t.additionalConfig)||void 0===n?void 0:n.page,from:t.from,to:t.to,dynamicDisplay:!1,fitTitleWidth:!0,excludeFirstRowLink:!0,sequencePrefix:null===(r=t.additionalConfig)||void 0===r?void 0:r.sequencePrefix}),this.annotationTracks=yield this.annotationCollector.collect({group:t.group,groupId:t.groupId,sources:null===(o=t.additionalConfig)||void 0===o?void 0:o.sources,filters:null===(a=t.additionalConfig)||void 0===a?void 0:a.filters,annotationProcessing:null===(c=t.additionalConfig)||void 0===c?void 0:c.annotationProcessing,externalAnnotationTrackBuilder:null===(s=t.additionalConfig)||void 0===s?void 0:s.externalTrackBuilder}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){this.rowConfigData=this.alignmentTracks.sequence?this.alignmentTracks.sequence.concat(this.annotationTracks):this.annotationTracks}}e.RcsbFvGroupAnnotation=d},function(t,e,n){"use 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Array&&t.targetAlignmentList.sort((t,e)=>t.target_id.localeCompare(e.target_id)).forEach(a=>{if(null!=t.filterByTargetContains&&!a.target_id.includes(t.filterByTargetContains))return;if(null==a.target_sequence)return;const i=a.target_sequence,s={queryId:t.queryId,targetId:a.target_id,from:t.from,to:t.to,targetSequenceLength:i.length};r.push(a.target_id);const p=[];let d=[];const h=[];a.aligned_regions.forEach(e=>{const r=i.substring(e.target_begin-1,e.target_end);this.buildSequenceData(Object.assign(Object.assign({},s),{sequenceData:p,sequence:r,begin:e.query_begin,oriBegin:e.target_begin}));let o=!1;1!=e.target_begin&&(o=!0);let c=!1;e.target_end!=i.length&&t.querySequence&&(c=!0),n(e,s,null==t.querySequence).forEach(e=>{var n,r;d.push(this.addAuthorResIds({begin:e.query_begin,end:e.query_end,oriBegin:e.target_begin,oriEnd:e.target_end,sourceId:a.target_id,source:t.to,provenanceName:l.RcsbAnnotationConstants.provenanceName.pdb,provenanceColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,openBegin:null!==(n=e.openBegin)&&void 0!==n?n:o,openEnd:null!==(r=e.openEnd)&&void 0!==r?r:c,type:"ALIGNED_BLOCK",title:e.unModelled?"UNMODELED REGION":"ALIGNED REGION",color:e.unModelled?"#AAAAAA":void 0},s))}),t.querySequence&&function(t,e){const n=[];if(t.length===e.length)for(let r=0;r<t.length;r++)t.charAt(r)!==e.charAt(r)&&n.push(r);return n}(r,t.querySequence.substring(e.query_begin-1,e.query_end)).forEach(n=>{h.push(this.addAuthorResIds({begin:n+e.query_begin,oriBegin:n+e.target_begin,sourceId:a.target_id,source:t.to,provenanceName:l.RcsbAnnotationConstants.provenanceName.pdb,provenanceColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"MISMATCH",title:"MISMATCH"},s))})}),u.FeatureTools.mergeBlocks(d);const f={displayType:"sequence",displayColor:"#000000",displayData:p,dynamicDisplay:e},m={displayType:"pin",displayColor:"#FF9999",displayData:h},g={displayType:"block",displayColor:"#9999FF",displayData:d};let v=t.to?t.to.replace("_"," ")+" "+c.TagDelimiter.alignmentTitle:"";const b={trackId:"targetSequenceTrack_"+a.target_id,displayType:"composite",trackColor:"#F9F9F9",rowPrefix:v,rowTitle:this.buildAlignmentRowTitle(a,t),fitTitleWidth:t.fitTitleWidth,titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,displayConfig:[g,m,f]};o.push(b)}),{targets:r,alignments:o}}buildSequenceData(t,e){let n=t.to;!0===e&&(n=t.from);let r=l.RcsbAnnotationConstants.provenanceColorCode.external;return n!=i.Source.PdbInstance&&n!=i.Source.PdbEntity||(n=l.RcsbAnnotationConstants.provenanceName.pdb,r=l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb),t.sequence.split("").forEach((e,o)=>{const a={begin:t.begin+o,sourceId:t.targetId,source:t.to,provenanceName:n,provenanceColor:r,value:e};"string"==typeof t.targetId&&(a.sourceId=t.targetId),"number"==typeof t.oriBegin&&(a.oriBegin=t.oriBegin+o),t.sequenceData.push(this.addAuthorResIds(a,{from:t.from,to:t.to,queryId:t.queryId,targetId:t.targetId}))}),t.sequenceData}buildSequenceRowTitle(t){var e;let n;return n=t.excludeFirstRowLink||t.from!==i.SequenceReference.Uniprot?t.excludeFirstRowLink||t.from!==i.SequenceReference.PdbInstance||null==this.entityInstanceTranslator?{visibleTex:null!==(e=t.queryId)&&void 0!==e?e:t.groupId,style:{fontWeight:"bold"}}:{visibleTex:this.buildInstanceId(t.queryId),style:{fontWeight:"bold"}}:{visibleTex:t.queryId,url:s.rcsb_uniprot.url+t.queryId,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}},n}buildAlignmentRowTitle(t,e){let n;if(e.to===i.SequenceReference.PdbInstance&&null!=this.entityInstanceTranslator){const e=this.entityInstanceTranslator.translateAsymToEntity(t.target_id.split(c.TagDelimiter.instance)[1]);n={visibleTex:this.buildInstanceId(t.target_id),url:s.rcsb_entry.url+t.target_id.split(c.TagDelimiter.instance)[0]+"#entity-"+e,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}}else if(e.to!==i.SequenceReference.PdbEntity||e.excludeAlignmentLinks)if(e.to!==i.SequenceReference.PdbInstance||e.excludeAlignmentLinks||null==this.entityInstanceTranslator)n=e.to===i.SequenceReference.Uniprot?{visibleTex:t.target_id,url:s.rcsb_uniprot.url+t.target_id,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}:t.target_id;else{const e=this.entityInstanceTranslator.translateAsymToEntity(t.target_id.split(c.TagDelimiter.instance)[1]);n={visibleTex:this.buildInstanceId(t.target_id),url:s.rcsb_entry.url+t.target_id.split(c.TagDelimiter.instance)[0]+"#entity-"+e,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}}else{const e=t.target_id.split(c.TagDelimiter.entity)[1];n={visibleTex:t.target_id,url:s.rcsb_entry.url+t.target_id.split(c.TagDelimiter.entity)[0]+"#entity-"+e,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}}return n}addAuthorResIds(t,e){let n=t;return null!=this.entityInstanceTranslator&&this.entityInstanceTranslator.addAuthorResIds(n,e),e.to==i.SequenceReference.PdbInstance&&null!=n.sourceId&&(n.sourceId=n.sourceId.split(c.TagDelimiter.instance)[0]+c.TagDelimiter.instance+this.entityInstanceTranslator.translateAsymToAuth(n.sourceId.split(c.TagDelimiter.instance)[1])),n}buildInstanceId(t){var e;const n=t.split(c.TagDelimiter.instance)[1],r=null===(e=this.entityInstanceTranslator)||void 0===e?void 0:e.translateAsymToAuth(n);return n!==r&&r?n+"[auth "+r+"]":n}setPolymerEntityInstanceTranslator(t){this.entityInstanceTranslator=t}}},function(t,e,n){"use strict";var r=this&&this.__createBinding||(Object.create?function(t,e,n,r){void 0===r&&(r=n),Object.defineProperty(t,r,{enumerable:!0,get:function(){return e[n]}})}:function(t,e,n,r){void 0===r&&(r=n),t[r]=e[n]}),o=this&&this.__setModuleDefault||(Object.create?function(t,e){Object.defineProperty(t,"default",{enumerable:!0,value:e})}:function(t,e){t.default=e}),a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return o(e,t),e},i=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.SwissModelQueryAnnotations=void 0;const c=a(n(22));class s{static request(t){return i(this,void 0,void 0,(function*(){const e=s.url+t+s.urlSuffix;try{const t=yield fetch(e),n=yield t.json();return s.parse(n)}catch(t){throw console.error(t),t}}))}static parse(t){const e=new Array;return t.result.structures.forEach(t=>{const n={provenance_source:t.provider,type:t.method,feature_positions:[{beg_seq_id:t.from,end_seq_id:t.to}]};e.push(n)}),[{features:e}]}}e.SwissModelQueryAnnotations=s,s.url=c.swiss_model.url,s.urlSuffix=c.swiss_model.url_suffix},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.AnnotationCollectorHelper=void 0;const r=n(50),o=n(16),a=n(30);class i{static buildAnnotationTrack(t,e,n,r){let a,c;const s=n;return null!==s&&(c=s.display),a="composite"===c||"bond"===c||"pin"===c?i.buildRcsbFvRowConfigComposite(t,e,n):"area"===c||"line"===c?i.buildRcsbFvRowConfigArea(t,e,n):"block-area"===c?i.buildRcsbFvRowConfigBlockArea(t,e,n):i.buildRcsbFvRowConfigTrack(t,e,n),null!=s&&"number"==typeof s.height&&(a.trackHeight=s.height),r instanceof Array&&1==r.length&&(r[0]===o.RcsbAnnotationConstants.provenanceName.pdb||r[0]===o.RcsbAnnotationConstants.provenanceName.promotif)?a.titleFlagColor=o.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb:a.titleFlagColor=o.RcsbAnnotationConstants.provenanceColorCode.external,a}static buildRcsbFvRowConfigTrack(t,e,n){const o=t.values();let a="block";o.length>0&&null==o[0].end&&(a="pin");let c=r.RcsbAnnotationConfig.randomRgba(),s=e,l=void 0;const u=n;return null!==u?(a=u.display,s=i.buildRowTitle(u),c=u.color,l=u.prefix):console.warn("Annotation config type "+e+" not found. Using random config"),Object.assign(Object.assign({},n),{trackId:"annotationTrack_"+e,displayType:a,trackColor:"#F9F9F9",displayColor:c,rowTitle:s,rowPrefix:l,trackData:o})}static buildRcsbFvRowConfigArea(t,e,n){var r;const o=t.values(),a=n,c=a.display,s=a.color,l=i.buildRowTitle(a),u=a.prefix;let p=t.getRange().min,d=t.getRange().max;p>=0?p=0:Math.abs(p)>Math.abs(d)?d=-p:p=-d;const h=null!==(r=a.domain)&&void 0!==r?r:[p,d];return Object.assign(Object.assign({},n),{trackId:"annotationTrack_"+e,displayType:c,trackColor:"#F9F9F9",displayColor:s,rowTitle:l,rowPrefix:u,displayDomain:h,interpolationType:"step",trackData:o})}static buildRcsbFvRowConfigBlockArea(t,e,n){const r=t.values(),o=n,a=o.display,c=o.color,s=i.buildRowTitle(o),l=o.prefix;return Object.assign(Object.assign({},n),{trackId:"annotationTrack_"+e,displayType:a,trackColor:"#F9F9F9",displayColor:c,rowTitle:s,rowPrefix:l,displayDomain:[0,1],interpolationType:"step",trackData:r})}static buildRcsbFvRowConfigComposite(t,e,n){var o;const a=t.values();let c;const s=n;let l="block";s.display==="bond".toString()&&(l="bond",a.forEach(t=>{t.isEmpty=!0}));const u=i.buildRowTitle(s),p=s.prefix,d=null!==(o=s.color)&&void 0!==o?o:r.RcsbAnnotationConfig.randomRgba(),h=new Array,f=new Array;if(a.forEach(t=>{null!==t.end&&t.end!==t.begin?f.push(t):h.push(t)}),h.length>0&&f.length>0){const t=new Array;t.push({displayData:f,displayType:l,displayColor:d}),t.push({displayData:h,displayType:"pin",displayColor:d}),c={displayType:"composite",trackColor:"#F9F9F9",trackId:"annotationTrack_"+e,rowTitle:u,rowPrefix:p,displayConfig:t}}else h.length>0&&(l="pin");return void 0===c&&(c={trackId:"annotationTrack_"+e,displayType:l,trackColor:"#F9F9F9",displayColor:d,rowTitle:u,rowPrefix:p,trackData:a}),c}static buildRowTitle(t){return t.prefix?a.FeatureTools.parseLink(t.title):t.title}}e.AnnotationCollectorHelper=i},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.AnnotationTrackManager=void 0;const o=n(112);e.AnnotationTrackManager=class{constructor(t){this.annotationTracks=new Map,this.rcsbAnnotationConfig=t}processRcsbPdbAnnotations(t,e){var n,o,a;return r(this,void 0,void 0,(function*(){yield this.addAnnotationToTracks(e,"function"==typeof(null===(n=e.externalAnnotationTrackBuilder)||void 0===n?void 0:n.filterFeatures)?yield null===(o=e.externalAnnotationTrackBuilder)||void 0===o?void 0:o.filterFeatures(t):t),null===(a=e.annotationProcessing)||void 0===a||a.computeAnnotationValue(this.annotationTracks),this.mergeTracks()}))}getAnnotationTracks(){return this.annotationTracks}getPolymerEntityInstanceTranslator(){return this.polymerEntityInstanceTranslator}setPolymerEntityInstanceTranslator(t){this.polymerEntityInstanceTranslator=t}mergeTracks(){this.annotationTracks.forEach((t,e)=>{if(this.rcsbAnnotationConfig.isMergedType(e)){const t=this.rcsbAnnotationConfig.getMergedType(e),n=this.rcsbAnnotationConfig.getConfig(e).color;this.annotationTracks.has(t)||this.annotationTracks.set(t,new o.AnnotationTrack(e,this.rcsbAnnotationConfig.getConfig(e),this.getPolymerEntityInstanceTranslator())),this.annotationTracks.get(t).addAll(this.annotationTracks.get(e),n),this.rcsbAnnotationConfig.addMultipleProvenance(t,Array.from(this.annotationTracks.get(t).getTrackProvenance())),this.annotationTracks.delete(e)}})}buildType(t,e,n){return r(this,void 0,void 0,(function*(){return this.rcsbAnnotationConfig.buildAndAddType(n,"function"==typeof t.trackTitle?yield t.trackTitle(e,n):void 0,"function"==typeof t.titleSuffix?yield t.titleSuffix(e,n):void 0)}))}addAnnotationToTracks(t,e){return r(this,void 0,void 0,(function*(){yield Promise.all(e.map(e=>e.features.map(n=>r(this,void 0,void 0,(function*(){return yield this.addFeature(t,e,n)})))).flat())}))}addFeature(t,e,n){var a;return r(this,void 0,void 0,(function*(){if(null===(a=this.rcsbAnnotationConfig.getConfig(n.type))||void 0===a?void 0:a.ignore)return;const r=yield this.buildType(t,e,n);this.annotationTracks.has(r)||this.annotationTracks.set(r,new o.AnnotationTrack(r,this.rcsbAnnotationConfig.getConfig(r),this.getPolymerEntityInstanceTranslator())),this.rcsbAnnotationConfig.addProvenance(r,n.provenance_source),this.annotationTracks.get(r).addFeature({reference:t.reference,queryId:t.queryId,source:e.source,targetId:e.target_id,feature:n},t.annotationProcessing)}))}}},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.AnnotationTrack=void 0;const r=n(7),o=n(16),a=n(10);e.AnnotationTrack=class{constructor(t,e,n){this.valueRange={max:Number.MIN_SAFE_INTEGER,min:Number.MAX_SAFE_INTEGER},this.trackElementMap=new Map,this.entityInstanceTranslator=n,this.type=t,this.annotationConfig=e}getRange(){return this.valueRange}addFeature(t,e){(function(t){const e=new Map,n=new Array;return t.forEach(t=>{null!=t.range_id?(e.has(t.range_id)||e.set(t.range_id,new Array),e.get(t.range_id).push(t)):n.push(t)}),e.forEach((t,e)=>{if(1==t.length)n.push(t[0]);else{const e=t.sort((t,e)=>t.beg_seq_id-e.beg_seq_id),r=Object.assign(Object.assign({},e[0]),{end_seq_id:e[e.length-1].end_seq_id,end_ori_id:e[e.length-1].end_ori_id,open_end:e[e.length-1].open_end,gaps:new Array});for(let t=0;t<e.length-1;t++)r.gaps.push({begin:e[t].end_seq_id,end:e[t+1].beg_seq_id,isConnected:null==e[t].beg_ori_id||null==e[t].end_ori_id||null==e[t+1].beg_ori_id||null==e[t+1].end_ori_id||e[t].end_ori_id+1==e[t+1].beg_ori_id||e[t].end_ori_id==e[t+1].beg_ori_id+1||e[t].end_ori_id==e[t+1].beg_ori_id});n.push(r)}}),n})(t.feature.feature_positions).forEach(n=>{null!=n.beg_seq_id&&this.annotationRangeKeys(n).forEach(r=>{this.addRange(t.reference,t.queryId,t.source,t.targetId,t.feature,n,r,e)})})}size(){return this.trackElementMap.size}forEach(t){this.trackElementMap.forEach((e,n)=>{t(e,n)})}addAll(t,e){t.forEach((t,n)=>{t.color=null!=e?e:t.color,this.trackElementMap.set(n,t)})}getTrackProvenance(){return new Set(Array.from(this.trackElementMap.values()).map(t=>t.provenanceName))}set(t,e){this.trackElementMap.set(t,e)}values(){return Array.from(this.trackElementMap.values())}buildRcsbFvTrackDataElement(t,e,n,i,c){var s,l,u,p,d,h;let f=null!==(l=null===(s=this.annotationConfig)||void 0===s?void 0:s.title)&&void 0!==l?l:this.type,m=void 0;this.isNumericalDisplay(this.type)&&(m=(null===(u=this.annotationConfig)||void 0===u?void 0:u.transformToNumerical)?1:t.values instanceof Array&&null!==(p=t.values[0])&&void 0!==p?p:0),t.values instanceof Array&&t.values.length>0?(Math.max(...t.values)>this.valueRange.max&&(this.valueRange.max=Math.max(...t.values)),Math.min(...t.values)<this.valueRange.min&&(this.valueRange.min=Math.min(...t.values))):"number"==typeof m&&(m>this.valueRange.max&&(this.valueRange.max=m),m<this.valueRange.min&&(this.valueRange.min=m));let g=o.RcsbAnnotationConstants.provenanceColorCode.external;c!==o.RcsbAnnotationConstants.provenanceName.pdb&&c!==o.RcsbAnnotationConstants.provenanceName.promotif||(g=o.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb);const v=i==r.Source.PdbInstance&&null!=this.entityInstanceTranslator?n.split(a.TagDelimiter.instance)[0]+a.TagDelimiter.instance+this.entityInstanceTranslator.translateAsymToAuth(n.split(a.TagDelimiter.instance)[1]):n;return{begin:t.beg_seq_id,end:null!==(d=t.end_seq_id)&&void 0!==d?d:t.beg_seq_id,oriBegin:t.beg_ori_id,oriEnd:null!==(h=t.end_ori_id)&&void 0!==h?h:t.beg_ori_id,description:new Array,featureId:e.feature_id,type:this.type,title:f,name:e.name,value:m,gValue:e.value,gaps:t.gaps,sourceId:v,source:i,provenanceName:c,provenanceColor:g,openBegin:t.open_begin,openEnd:t.open_end}}addRange(t,e,n,r,o,a,i,c){var s,l;const u=i.join(":");if(this.trackElementMap.has(u))this.isNumericalDisplay(this.type)&&(null===(l=this.annotationConfig)||void 0===l?void 0:l.transformToNumerical)&&"number"==typeof this.trackElementMap.get(u).value&&(this.trackElementMap.get(u).value+="function"==typeof(null==c?void 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c.rcsbFvCtxManager.getEntityToInstance(a)).getData(),p=new Set;u.sort((t,e)=>parseInt(t.entityId)-parseInt(e.entityId)).forEach(t=>{p.add(t.entryId+o.TagDelimiter.entity+t.entityId)});const d=(yield c.rcsbFvCtxManager.getEntityToChromosome(Array.from(p))).getData();if(0==d.size)i.RcsbFvCoreBuilder.showMessage(t,"No genome alignments are available");else{const a=new Set;i.RcsbFvCoreBuilder.buildSelectButton(t,e,u.filter(t=>{const e=a.has(t.entryId+o.TagDelimiter.entity+t.entityId);return a.add(t.entryId+o.TagDelimiter.entity+t.entityId),d.has(t.entryId+o.TagDelimiter.entity+t.entityId)&&!e}).map((e,a)=>{const i=e.entryId+o.TagDelimiter.entity+e.entityId;return 0==a&&s.buildEntityChromosome(t,n,i).then(t=>{l(t)}),{name:e.names+" - "+e.taxIds.join(", "),label:i+" - "+e.names,shortLabel:i,onChange:()=>r(this,void 0,void 0,(function*(){yield s.buildEntityChromosome(t,n,i)}))}}),{addTitle:!0,dropdownTitle:"ENTITY"})}})))}))}static buildEntityChromosome(t,e,n){return r(this,void 0,void 0,(function*(){const o=yield s.buildChromosome(t,n,null,e,{boardConfig:{rowTitleWidth:160}}),a=yield o.getTargets();return i.RcsbFvCoreBuilder.buildSelectButton(t,e,a.map((o,a)=>({label:o,name:o,shortLabel:o,onChange:()=>r(this,void 0,void 0,(function*(){yield s.buildChromosome(t,n,o,e)}))})),{addTitle:!1,width:190,dropdownTitle:"CHROMOSOME"}),o}))}static buildChromosome(t,e,n,c,s){return r(this,void 0,void 0,(function*(){return new Promise((r,l)=>{try{i.RcsbFvCoreBuilder.createFv({elementId:t,fvModuleI:a.RcsbFvChromosome,config:{entityId:e,chrId:n,elementSelectId:c,additionalConfig:Object.assign({rcsbContext:{entryId:e.split(o.TagDelimiter.entity)[0],entityId:e.split(o.TagDelimiter.entity)[1],chrId:n}},s),resolve:r}})}catch(t){l(t)}})}))}}e.RcsbFvChromosomeBuilder=s},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))},o=this&&this.__importDefault||function(t){return t&&t.__esModule?t:{default:t}};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvChromosome=void 0;const a=n(19),i=n(14),c=n(7),s=n(37),l=n(16),u=n(127),p=n(43),d=n(128),h=n(129),f=o(n(145)),m=n(31);function g(t,e,n){return r=>{if((n?n/(r.to-r.from):1e3/(r.to-r.from))>4){const n=new Array;return e.forEach((t,e)=>{e[0]>r.to||e[1]<r.from||n.push(t)}),Promise.all(n.map(e=>(new p.RcsbQueryAlignment).request({queryId:e,from:t,to:c.SequenceReference.NcbiGenome}))).then(e=>{const r=new s.RcsbFvTrackData;return e.forEach((e,o)=>{if(null==e.query_sequence)return;const a=e.query_sequence.split("");e.target_alignment.forEach(e=>{const i=e.orientation;e.aligned_regions.forEach(e=>{const c=e.target_begin,s=e.query_begin,l=e.query_end-e.query_begin+1;for(let e=0;e<l;e++)r.push({begin:c+i*(1+3*e),value:a[s-1+e],oriBegin:s+e,source:t.toString(),sourceId:n[o]})})})}),r})}return new Promise((t,e)=>{t(null)})}}class v extends i.RcsbFvAbstractModule{constructor(){super(...arguments),this.targetAlignmentList=new Map([[c.SequenceReference.NcbiProtein,new Array],[c.SequenceReference.Uniprot,new Array],[c.SequenceReference.PdbEntity,new Array]]),this.maxRange=0,this.minRange=Number.MAX_SAFE_INTEGER,this.alignmentCollectorQueue=new u.RcsbFvAlignmentCollectorQueue(12),this.nTasks=0,this.completeTasks=0,this.batchSize=1e7,this.beginView=0,this.endView=0,this.entityBegin=0,this.entityEnd=0,this.nonExonConfigData=new Array,this.featuresConfigData=new Array,this.targetCoverages=new Map,this.chrSet=new Array,this.targetFilterFlag=!0,this.IDEOGRAM_DIV_ID="chrIdeogramDiv",this.TITLE_CHR_DIV_ID="chrTitleDiv",this.TITLE_CHR_REGION_ID="chrTitleRegion",this.currentDisplayedChrId="",this.buildSubject=new a.Subject,this.targetsSubject=new a.Subject}buildPdbGenomeFv(t,e){this.entityId=t;const n=new p.RcsbQueryAlignment;Promise.all([c.SequenceReference.NcbiProtein,c.SequenceReference.Uniprot].map(e=>n.request({queryId:t,from:c.SequenceReference.PdbEntity,to:e}))).then(n=>{n.forEach(t=>{t.target_alignment.forEach(t=>{this.targetCoverages.set(t.target_id,t.coverage)})}),this.alignmentCollectorQueue.sendTask({queryId:t,from:c.SequenceReference.PdbEntity,to:c.SequenceReference.NcbiGenome},n=>r(this,void 0,void 0,(function*(){const r=n;yield this.collectPdbWorkerResults(r,t,e)})))})}buildFullGenomeRangeFv(t){this.plotChromosomeTitle(t),this.targetFilterFlag=!1,this.genomeSequenceTracks(t),this.collectChromosomeAlignments(t,c.SequenceReference.PdbEntity),this.collectChromosomeAlignments(t,c.SequenceReference.Uniprot),this.collectChromosomeAlignments(t,c.SequenceReference.NcbiProtein)}collectPdbWorkerResults(t,e,n){return r(this,void 0,void 0,(function*(){const r=this.collectExons(t.target_alignment,"target",l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,c.SequenceReference.PdbEntity,n);this.pdbEntityTrack=this.mergeExonTracks(r,c.SequenceReference.PdbEntity)[0],this.pdbEntityTrack.displayConfig[0].displayData.forEach(t=>{t.description=[e]}),this.addSequences([this.pdbEntityTrack],c.SequenceReference.PdbEntity),this.pdbEntityTrack.rowPrefix=c.SequenceReference.PdbEntity.replace("_"," "),this.pdbEntityTrack.rowTitle={visibleTex:e,style:{fontWeight:"bold"}},this.pdbEntityTrack.hideEmptyTrackFlag=!1,yield this.buildChromosomeFv(null!=n?n:this.chrSet[0])}))}buildChromosomeFv(t){return r(this,void 0,void 0,(function*(){this.plotChromosomeTitle(t),this.genomeSequenceTracks(t),this.nonExonConfigData.push(this.pdbEntityTrack),yield this.plot(),this.collectChromosomeEntityRegion(t)}))}plotChromosomeTitle(t){var e,n;null===(e=document.getElementById(this.IDEOGRAM_DIV_ID))||void 0===e||e.remove(),null===(n=document.getElementById(this.TITLE_CHR_DIV_ID))||void 0===n||n.remove(),this.currentDisplayedChrId=t,h.NcbiSummary.requestChromosomeData(t).then(e=>{if(t==this.currentDisplayedChrId){const t=document.createElement("div");t.id=this.IDEOGRAM_DIV_ID;const n=document.createElement("div");n.style.display="inline-block",n.style.marginLeft="20px",n.id=this.TITLE_CHR_DIV_ID;const r=document.createElement("span");r.innerHTML=e.title,n.append(r);const o=document.createElement("span");o.id=this.TITLE_CHR_REGION_ID,o.innerHTML=" / Region: ["+this.entityBegin+" - "+this.entityEnd+"]",o.style.color="#666",n.append(o),document.getElementById(this.elementSelectId).insertAdjacentElement("afterend",n),document.getElementById(this.elementId).insertAdjacentElement("beforebegin",t),this.plotIdeogram(e)}})}updateChromosomeTitleRegion(){const t=document.getElementById(this.TITLE_CHR_REGION_ID);null!=t&&(t.innerHTML=" / Region: ["+this.beginView+" - "+this.endView+"]")}plotIdeogram(t){h.NcbiSummary.requestTaxonomyData(t.taxid.toString()).then(e=>{if(t.ncbiId==this.currentDisplayedChrId){const n=t.subname.includes("|")?t.subname.split("|").filter(t=>null!=t.match(/^([\dXYxy]+)$/))[0]:t.subname,r=new f.default({rotatable:!1,chrHeight:1080,chrWidth:20,organism:e.scientificname,chromosomes:[n],orientation:"horizontal",container:"#"+this.IDEOGRAM_DIV_ID,annotationHeight:8,showBandLabels:!0,annotations:[{name:this.entityId,chr:n,start:this.entityBegin,stop:this.entityEnd}],onLoad:()=>{var t,e;(null===(t=r.chromosomesArray)||void 0===t?void 0:t.length)>0?null!=document.getElementById("_ideogram")&&(document.getElementById("_ideogram").style.padding="0 0 0 0"):null===(e=document.getElementById(this.IDEOGRAM_DIV_ID))||void 0===e||e.remove()}})}})}genomeSequenceTracks(t){var e,n,r,o;this.nonExonConfigData.push({trackId:"mainSequenceTrack_5_"+t,displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",nonEmptyDisplay:!0,rowPrefix:t+" ",rowTitle:{visibleTex:"5'",style:{fontWeight:"bold"}},titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.external,updateDataOnMove:d.NcbiGenomeSequenceData.update(t,1,!1,null===(n=null===(e=this.rcsbFv)||void 0===e?void 0:e.getBoardConfig())||void 0===n?void 0:n.trackWidth)}),this.nonExonConfigData.push({trackId:"mainSequenceTrack_3_"+t,displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",rowPrefix:"",nonEmptyDisplay:!0,rowTitle:{visibleTex:"3'",style:{fontWeight:"bold"}},titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.external,updateDataOnMove:d.NcbiGenomeSequenceData.update(t,2,!0,null===(o=null===(r=this.rcsbFv)||void 0===r?void 0:r.getBoardConfig())||void 0===o?void 0:o.trackWidth)})}collectChromosomeEntityRegion(t){const e=this.pdbEntityTrack.displayConfig[0].displayData[0].begin,n=this.pdbEntityTrack.displayConfig[0].displayData[0].end,r=[Math.max(1,e-5e6),n+5e6];this.collectChromosomeAlignments(t,c.SequenceReference.Uniprot,r,0),this.collectChromosomeAlignments(t,c.SequenceReference.NcbiProtein,r,0)}collectChromosomeAlignments(t,e,n,o){if(null!=n)this.nTasks++,this.alignmentCollectorQueue.sendTask({queryId:t,from:c.SequenceReference.NcbiGenome,to:e,range:n},t=>r(this,void 0,void 0,(function*(){const n=t;yield this.collectChromosomeWorkerResults(o,e,n,!1)})));else for(let n=0;n<30;n++)this.nTasks++,this.alignmentCollectorQueue.sendTask({queryId:t,from:c.SequenceReference.NcbiGenome,to:e,range:[n*this.batchSize,(n+1)*this.batchSize]},t=>r(this,void 0,void 0,(function*(){const r=t;yield this.collectChromosomeWorkerResults(n,e,r,!1)})))}collectChromosomeWorkerResults(t,e,n,o){return r(this,void 0,void 0,(function*(){this.completeTasks++,this.targetAlignmentList.get(e)[t]=n.target_alignment,console.log("Completed "+Math.floor(this.completeTasks/this.nTasks*100)+"%"),o?yield this.plot():this.nTasks==this.completeTasks&&(console.log("All Tasks Completed. Starting Rendering"),this.alignmentCollectorQueue.terminateWorkers(),yield this.plot())}))}collectExons(t,e,n,r,o,a){const i=new Array;return t.forEach((t,n)=>{0==t.aligned_regions.length||"query"==e&&this.targetFilterFlag&&!this.targetCoverages.has(t.target_id)||"target"==e&&null!=a&&a!=t.target_id||i.push({data:[this.normalizeTargetAlignment(t,e)],id:t.target_id})}),this.simplifyExonTracks(i.sort((t,e)=>{const n=t.data,r=e.data;return n[0].begin!=r[0].begin?n[0].begin-r[0].begin:r[0].end!=n[0].end?r[0].end-n[0].end:n[0].gaps.map(t=>t.end-t.begin).reduce((t,e)=>t+e,0)-r[0].gaps.map(t=>t.end-t.begin).reduce((t,e)=>t+e,0)}).map(t=>("target"!=e||this.chrSet.includes(t.id)||this.chrSet.push(t.id),t.data)),e,o).map((t,e)=>({trackId:"pdbTracks_"+Math.random().toString(36).substr(2),displayType:"composite",trackColor:"#F9F9F9",rowTitle:"",titleFlagColor:r,overlap:!0,displayConfig:[{displayType:"block",displayData:t,displayColor:n,selectDataInRangeFlag:!0,hideEmptyTrackFlag:!0,minRatio:2e-4}]}))}normalizeTargetAlignment(t,e){const n="query"===e?"query_begin":"target_begin",r="query"===e?"query_end":"target_end",o={begin:Math.min(t.aligned_regions[0][n],t.aligned_regions[t.aligned_regions.length-1][r]),end:Math.max(t.aligned_regions[0][n],t.aligned_regions[t.aligned_regions.length-1][r]),gaps:[],description:[t.target_id],openBegin:t.orientation<0,openEnd:t.orientation>0};return t.orientation>0?("query"==e&&t.aligned_regions[t.aligned_regions.length-1][r]>this.maxRange&&(this.maxRange=t.aligned_regions[t.aligned_regions.length-1][r]),"query"==e&&t.aligned_regions[0][n]<this.minRange&&(this.minRange=t.aligned_regions[0][n]),t.aligned_regions.forEach((e,a)=>{if(a+1<t.aligned_regions.length){const i=t.aligned_regions[a+1];let c=e[r],s=i[n];const l=e.exon_shift;1==(null==l?void 0:l.length)?(1==Math.abs(l[0]-s)||o.gaps.push({end:l[0],begin:c,isConnected:!0}),s=l[0]):2==(null==l?void 0:l.length)&&(1==Math.abs(l[1]-s)&&1==Math.abs(l[1]-l[0])?s=l[0]:1==Math.abs(l[1]-s)?(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0],s=l[1]):1==Math.abs(l[1]-l[0])?(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[1]):(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0],o.gaps.push({end:l[1],begin:c,isConnected:!0}),c=l[1])),o.gaps.push({begin:c,end:s,isConnected:!0})}})):("query"==e&&t.aligned_regions[0][n]>this.maxRange&&(this.maxRange=t.aligned_regions[0][n]),"query"==e&&t.aligned_regions[t.aligned_regions.length-1][r]<this.minRange&&(this.minRange=t.aligned_regions[t.aligned_regions.length-1][r]),t.aligned_regions.reverse().forEach((e,a)=>{if(a+1<t.aligned_regions.length){const i=t.aligned_regions[a+1];let c=e[n],s=i[r];const l=i.exon_shift;1==(null==l?void 0:l.length)?(1==Math.abs(l[0]-c)||o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0]):2==(null==l?void 0:l.length)&&(1==Math.abs(l[1]-c)&&1==Math.abs(l[1]-l[0])?c=l[0]:1==Math.abs(l[1]-c)?(c=l[1],o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0]):1==Math.abs(l[1]-l[0])?(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[1]):(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0],o.gaps.push({end:l[1],begin:c,isConnected:!0}),c=l[1])),o.gaps.push({end:s,begin:c,isConnected:!0})}})),o}simplifyExonTracks(t,e,n){const r=new Array;return t.forEach(t=>{const e=t[0].begin,n=t[0].end;if(0==r.length)this.entityBegin>0&&this.entityEnd>0&&!(e>this.entityEnd||n<this.entityBegin)&&(e<this.beginView&&(this.beginView=e),n>this.endView&&(this.endView=n)),r.push(t);else{const o=r.length-1,a=r[o][0].begin,i=r[o][0].end;e+"."+t[0].gaps.map(t=>t.begin+"."+t.end).join(".")+"."+n!=a+"."+r[o][0].gaps.map(t=>t.begin+"."+t.end).join(".")+"."+i?(this.entityBegin>0&&this.entityEnd>0&&!(e>this.entityEnd||n<this.entityBegin)&&(e<this.beginView&&(this.beginView=e),n>this.endView&&(this.endView=n)),r.push(t)):r[o][0].description.push(t[0].description[0])}}),r}mergeExonTracks(t,e){const n=new Array;return t.forEach(t=>{if(0==n.length)n.push(t);else{const e=t.displayConfig[0].displayData[0].begin;let r=-1;n.forEach((t,n)=>{const o=t.displayConfig[0].displayData.length-1,a=t.displayConfig[0].displayData[o].end;e>a&&-1==r&&(r=n)}),r>=0?n[r].displayConfig[0].displayData.push(t.displayConfig[0].displayData[0]):-1==r&&n.push(t)}}),this.addSequences(n,e),n}addSequences(t,e){t.forEach(t=>{var n,r;const o=new Map;t.displayConfig[0].displayData.forEach(t=>{o.set([t.begin,t.end],t.description[0])}),t.displayConfig.push({displayType:"sequence",updateDataOnMove:g(e,o,null===(r=null===(n=this.rcsbFv)||void 0===n?void 0:n.getBoardConfig())||void 0===r?void 0:r.trackWidth),displayData:[],hideEmptyTrackFlag:!0,minRatio:.001})})}setDisplayView(){var t,e,n,o;return r(this,void 0,void 0,(function*(){if(0==this.entityBegin&&0==this.entityEnd&&(null===(e=null===(t=this.pdbEntityTrack)||void 0===t?void 0:t.displayConfig)||void 0===e?void 0:e.length)>0){const t=this.pdbEntityTrack.displayConfig[0].displayData.length-1;this.entityBegin=this.pdbEntityTrack.displayConfig[0].displayData[0].begin,this.entityEnd=this.pdbEntityTrack.displayConfig[0].displayData[t].end,this.beginView=this.pdbEntityTrack.displayConfig[0].displayData[0].begin,this.endView=this.pdbEntityTrack.displayConfig[0].displayData[t].end;const e=this.beginView,n=this.endView,r=n-e;this.boardConfigData.range={min:e-Math.ceil(.05*r),max:n+Math.ceil(.05*r)}}else if((null===(o=null===(n=this.pdbEntityTrack)||void 0===n?void 0:n.displayConfig)||void 0===o?void 0:o.length)>0){this.beginView=this.minRange,this.endView=this.maxRange;const t=this.beginView,e=this.endView,n=e-t;this.boardConfigData.range={min:t-Math.ceil(.05*n),max:e+Math.ceil(.05*n)},this.updateChromosomeTitleRegion()}yield this.display()}))}plot(){var t;return r(this,void 0,void 0,(function*(){console.log("PROCESSING");let e=new Array,n=new Array;this.targetAlignmentList.get(c.SequenceReference.NcbiProtein).forEach((t,e)=>{t.length>0&&(n=n.concat(this.collectExons(t,"query","#69b3a2","#69b3a2",c.SequenceReference.NcbiProtein)))}),n=this.mergeExonTracks(n,c.SequenceReference.NcbiProtein);let r=new Array;this.targetAlignmentList.get(c.SequenceReference.Uniprot).forEach((t,e)=>{t.length>0&&(r=r.concat(this.collectExons(t,"query","#cc99ff","#cc99ff",c.SequenceReference.Uniprot)))}),r=this.mergeExonTracks(r,c.SequenceReference.Uniprot);let o=new Array;this.targetAlignmentList.get(c.SequenceReference.PdbEntity).forEach((t,e)=>{t.length>0&&(o=o.concat(this.collectExons(t,"query",l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,c.SequenceReference.PdbEntity)))}),o=this.mergeExonTracks(o,c.SequenceReference.PdbEntity),n.length>0&&(e=e.concat(n),n[0].rowTitle="NCBI PROTEINS"),r.length>0&&(e=e.concat(r),r[0].rowTitle="UNIPROT PROTEINS"),o.length>0&&(e=e.concat(o),o[0].rowTitle="PDB ENTITIES");const a=(null===(t=this.featuresConfigData)||void 0===t?void 0:t.length)>0?this.nonExonConfigData.concat(this.featuresConfigData):this.nonExonConfigData;e.length>0?this.rowConfigData=a.concat(e):this.rowConfigData=a,console.log("RENDERING"),this.boardConfigData.hideInnerBorder=!0,this.boardConfigData.length=Math.floor(this.maxRange+.01*this.maxRange),this.boardConfigData.includeAxis=!0,yield this.setDisplayView(),this.buildSubject.next(void 0),this.targetsSubject.next(this.chrSet)}))}protectedBuild(t){return r(this,void 0,void 0,(function*(){return new Promise((e,n)=>{m.ObservableHelper.oneTimeSubscription(e,this.buildSubject),t.elementSelectId&&(this.elementSelectId=t.elementSelectId),null!=t.entityId?this.buildPdbGenomeFv(t.entityId,t.chrId):null!=t.chrId&&this.buildFullGenomeRangeFv(t.chrId)})}))}getTargets(){return r(this,void 0,void 0,(function*(){return new Promise((t,e)=>{this.chrSet.length>0?t(this.chrSet):m.ObservableHelper.oneTimeSubscription(t,this.targetsSubject)})}))}concatAlignmentAndAnnotationTracks(t){}}e.RcsbFvChromosome=v},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvAlignmentCollectorQueue=void 0;const r=n(19);e.RcsbFvAlignmentCollectorQueue=class{constructor(t){this.workerList=new Array,this.taskQueue=new Array,this.isQueueActive=!1,this.nWorkers=null!=t?t:self.navigator.hardwareConcurrency;for(let t=0;t<this.nWorkers;t++)this.workerList.push({available:!0,worker:new Worker("/saguaro/worker.js")})}sendTask(t,e){const n=this.workerList.filter(t=>t.available);n.length>0?(n[0].available=!1,n[0].worker.postMessage(t),n[0].worker.onmessage=t=>{e(t.data),n[0].available=!0}):(this.taskQueue.push({request:t,callback:e}),this.isQueueActive||this.activateQueue())}activateQueue(){this.isQueueActive=!0,this.recursiveExec()}recursiveExec(){0==this.taskQueue.length?this.isQueueActive=!1:(this.isQueueActive=!0,this.workerList.filter(t=>t.available).forEach(t=>{if(this.taskQueue.length>0){t.available=!1;const e=this.taskQueue.shift();t.worker.postMessage(e.request),t.worker.onmessage=n=>{e.callback(n.data),t.available=!0}}}),r.asyncScheduler.schedule(()=>{this.recursiveExec()},1e3))}terminateWorkers(){this.workerList.forEach(t=>{t.worker.terminate()})}}},function(t,e,n){"use strict";var r=this&&this.__createBinding||(Object.create?function(t,e,n,r){void 0===r&&(r=n),Object.defineProperty(t,r,{enumerable:!0,get:function(){return e[n]}})}:function(t,e,n,r){void 0===r&&(r=n),t[r]=e[n]}),o=this&&this.__setModuleDefault||(Object.create?function(t,e){Object.defineProperty(t,"default",{enumerable:!0,value:e})}:function(t,e){t.default=e}),a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return o(e,t),e};Object.defineProperty(e,"__esModule",{value:!0}),e.NcbiGenomeSequenceData=void 0;const i=n(19),c=a(n(22));class s{static update(t,e,n,r){let o=null;return a=>(o&&o.unsubscribe(),new Promise((c,l)=>{if((r?r/(a.to-a.from):1e3/(a.to-a.from))>4){let r=0;const u=5e3,p=()=>{const d=new XMLHttpRequest;d.timeout=u;const h=s.urlPrefix+"id="+t+"&from="+a.from+"&to="+a.to+"&strand="+e+s.urlSuffix;d.open("GET",h),d.send(),d.onloadend=t=>{const e=d.responseText.split("\n").slice(1).join("");if(e.length<1)r++,console.warn("HTTP error while access URL: "+h+" - empty sequence - "+r),r<4?o=i.asyncScheduler.schedule(()=>{p()},u):l("HTTP error while access URL: "+h+" - No more attempts after "+r);else{const t=[{begin:a.from,value:n?e.split("").reverse().join(""):e}];c(t)}},d.onerror=t=>{r++,console.warn("HTTP error while access URL: "+h+" - "+r),r<4?o=i.asyncScheduler.schedule(()=>{p()},u):l("HTTP error while access URL: "+h+" - No more attempts after "+r)}};p()}else c(null)}))}}e.NcbiGenomeSequenceData=s,s.urlPrefix=c.ncbi_genome_sequence.url,s.urlSuffix=c.ncbi_genome_sequence.url_suffix},function(t,e,n){"use strict";var r=this&&this.__createBinding||(Object.create?function(t,e,n,r){void 0===r&&(r=n),Object.defineProperty(t,r,{enumerable:!0,get:function(){return e[n]}})}:function(t,e,n,r){void 0===r&&(r=n),t[r]=e[n]}),o=this&&this.__setModuleDefault||(Object.create?function(t,e){Object.defineProperty(t,"default",{enumerable:!0,value:e})}:function(t,e){t.default=e}),a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return o(e,t),e};Object.defineProperty(e,"__esModule",{value:!0}),e.NcbiSummary=void 0;const i=n(19),c=a(n(22));class s{static requestChromosomeData(t){s.jobTask&&s.jobTask.unsubscribe();const e=c.ncbi_summary_nuccore.url,n=c.ncbi_summary_nuccore.url_suffix;return new Promise((r,o)=>{const a=()=>{const o=e+t+n,c=new XMLHttpRequest;c.timeout=s.httpTimeout,c.open("GET",o),c.send(),c.onloadend=e=>{var n,o;if(0==c.responseText.length)s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout);else{const e=JSON.parse(c.responseText),a=null===(o=null===(n=e)||void 0===n?void 0:n.result)||void 0===o?void 0:o.uids[0],i=e.result[a];i.ncbiId=t,r(i)}},c.onerror=t=>{s.jobTask&&s.jobTask.unsubscribe(),s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout)}};a()})}static requestTaxonomyData(t){s.jobTask&&s.jobTask.unsubscribe();const e=c.ncbi_summary_taxonomy.url,n=c.ncbi_summary_taxonomy.url_suffix;return new Promise((r,o)=>{const a=()=>{const o=e+t+n,c=new XMLHttpRequest;c.timeout=s.httpTimeout,c.open("GET",o),c.send(),c.onloadend=t=>{var e,n;if(0==c.responseText.length)s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout);else{const t=JSON.parse(c.responseText),o=null===(n=null===(e=t)||void 0===e?void 0:e.result)||void 0===n?void 0:n.uids[0];r(t.result[o])}},c.onerror=t=>{s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout)}};a()})}}e.NcbiSummary=s,s.timeout=3e3,s.httpTimeout=1e4,s.jobTask=null},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvPairwiseAligmentBuilder=void 0;const o=n(12),a=n(131);e.RcsbFvPairwiseAligmentBuilder=class{static buildPairwiseAlignment(t,e,n){return r(this,void 0,void 0,(function*(){return new Promise((r,i)=>{try{o.RcsbFvCoreBuilder.createFv({elementId:t,fvModuleI:a.RcsbFvPairwiseAlignment,config:{psa:e,additionalConfig:Object.assign({rcsbContext:{queryId:e.queryId,targetId:e.targetId}},n),resolve:r}})}catch(t){i(t)}})}))}}},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvPairwiseAlignment=void 0;const o=n(14),a=n(132);class i extends o.RcsbFvAbstractModule{protectedBuild(t){var e;return r(this,void 0,void 0,(function*(){const n=new a.PairwiseAlignmentBuilder(t.psa),r=Object.assign({rowTitleWidth:120,trackWidth:800,length:n.getLength(),includeAxis:!t.psa.pairwiseView},null===(e=t.additionalConfig)||void 0===e?void 0:e.boardConfig);this.boardConfigData=Object.assign(Object.assign({},this.boardConfigData),r),this.rowConfigData=t.psa.pairwiseView?n.buildPairwiseAlignment():n.buildReferenceAlignment()}))}concatAlignmentAndAnnotationTracks(t){}}e.RcsbFvPairwiseAlignment=i},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.PairwiseAlignmentBuilder=void 0;const r=n(16),o=n(7),a=n(30),i=(t,e,n)=>{const r=n,o=1-r;return[Math.round(t[0]*r+e[0]*o),Math.round(t[1]*r+e[1]*o),Math.round(t[2]*r+e[2]*o)]};e.PairwiseAlignmentBuilder=class{constructor(t){if(this.querySequence=t.querySequence,this.targetSequence=t.targetSequence,this.queryAlignment=t.queryAlignment,this.targetAlignment=t.targetAlignment,this.queryBegin=t.queryBegin,this.queryEnd=t.queryEnd,this.targetBegin=t.targetBegin,this.targetEnd=t.targetEnd,this.targetId=t.targetId,this.queryId=t.queryId,this.sequenceId=t.sequenceId,this.isQueryExternal=t.isQueryExternal,this.isTargetExternal=t.isTargetExternal,this.pairwiseView=t.pairwiseView,this.queryAlignment.length!=this.targetAlignment.length)throw"Sequence alignments length mismatch";this.pairwiseView?this.alignmentLength=this.queryAlignment.length:this.alignmentLength=this.querySequence.length}getLength(){return this.alignmentLength}buildReferenceAlignment(){const t=this.queryAlignment.split(""),e=this.targetAlignment.split(""),n=[],a=[],c=[];let s=this.queryBegin,l=this.targetBegin,u=this.queryBegin,p=this.targetBegin;t.forEach((t,i)=>{const d=e[i];("-"===d||"-"===t)&&u>0&&(n.push({begin:u,end:s-1,oriBegin:p,oriEnd:l-1,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"}),u=0),"-"!=t&&"-"!=d&&(c.push({begin:s,oriBegin:l,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,value:d,type:"RESIDUE",title:"RESIDUE"}),t!=d&&a.push({begin:s,oriBegin:l,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"MISMATCH",title:"MISMATCH"})),"-"!=d&&"-"!=t&&0==u&&(u=s,p=l),"-"!=t&&s++,"-"!=d&&l++}),u>0&&n.push({begin:u,end:s-1,oriBegin:p,oriEnd:l-1,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"}),this.addBlockTerminalTags(n);const d={trackId:"query_sequence",displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",titleFlagColor:this.isQueryExternal?r.RcsbAnnotationConstants.provenanceColorCode.external:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:this.queryId,nonEmptyDisplay:!0,trackData:[{value:this.querySequence,begin:1}]},h={displayType:"sequence",displayColor:"#333333",displayData:c},f={displayType:"pin",displayColor:"#FF9999",displayData:a,minRatio:5},m={displayType:"block",displayColor:"rgb("+i([153,153,255],[50,50,50],this.sequenceId).join(",")+")",displayData:n};return[d,{trackId:"targetSequenceTrack",rowTitle:this.targetId,displayType:"composite",trackColor:"#F9F9F9",titleFlagColor:this.isTargetExternal?r.RcsbAnnotationConstants.provenanceColorCode.external:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,displayConfig:[m,f,h]}]}buildPairwiseAlignment(){const t=this.queryAlignment.split(""),e=this.targetAlignment.split(""),n=[],a=[],c=[],s=[];let l=this.queryBegin,u=this.targetBegin,p=1;t.forEach((t,i)=>{const d=e[i];"-"===t||"-"===d?p>0&&i>p&&(n.push({begin:p,end:i,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"}),p=0):"-"!=t&&"-"!=d&&0==p&&(p=i+1),"-"!=t&&"-"!=d&&t!=d&&p>0&&a.push({begin:i+1,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"MISMATCH",title:"MISMATCH"}),c.push({begin:i+1,value:t,source:r.RcsbAnnotationConstants.provenanceName.userInput,sourceId:"QUERY SEQUENCE",provenanceName:r.RcsbAnnotationConstants.provenanceName.userInput,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.external,oriBegin:"-"!=t?l:void 0}),"-"!=t&&l++,s.push({begin:i+1,value:d,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:o.SequenceReference.PdbEntity,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,oriBegin:"-"!=d?u:void 0}),"-"!=d&&u++}),p>0&&n.push({begin:p,end:this.alignmentLength,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"});const d={trackId:"query_sequence",displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",rowTitle:"QUERY",nonEmptyDisplay:!0,trackData:c},h={trackId:"target_sequence",displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",rowTitle:this.targetId,nonEmptyDisplay:!0,trackData:s},f={displayType:"pin",displayColor:"#FF9999",displayData:a,minRatio:5},m={displayType:"block",displayColor:"rgb("+i([153,153,255],[50,50,50],this.sequenceId).join(",")+")",displayData:n};return[d,{trackId:"targetSequenceTrack",displayType:"composite",trackColor:"#F9F9F9",titleFlagColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,displayConfig:[m,f]},h]}addBlockTerminalTags(t){t[0].oriBegin>1&&(t[0].openBegin=!0);for(let e=0;e<t.length-1;e++)t[e].oriEnd+1!=t[e+1].oriBegin&&(t[e].openEnd=!0,t[e+1].openBegin=!0);t[t.length-1].oriEnd<this.targetSequence.length&&(t[t.length-1].openEnd=!0),a.FeatureTools.mergeBlocks(t)}}},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvUniprotEntity=void 0;const o=n(7),a=n(14),i=n(10);class c extends a.RcsbFvAbstractModule{protectedBuild(t){return r(this,void 0,void 0,(function*(){const e=t.upAcc,n=t.entityId,r=t.additionalConfig,a=[{field:o.FieldName.TargetId,operation:o.OperationType.Equals,source:o.Source.PdbEntity,values:[n]}];this.alignmentTracks=yield this.sequenceCollector.collect({queryId:e,from:o.SequenceReference.Uniprot,to:o.SequenceReference.PdbEntity,filterByTargetContains:n,excludeAlignmentLinks:!0}),this.annotationTracks=yield this.annotationCollector.collect({queryId:e,reference:o.SequenceReference.Uniprot,sources:(null==r?void 0:r.sources)?r.sources:[o.Source.PdbEntity,o.Source.Uniprot],filters:(null==r?void 0:r.filters)instanceof Array?r.filters.concat(a):a,titleSuffix:this.titleSuffix.bind(this)}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){this.rowConfigData=this.alignmentTracks.sequence.concat(this.alignmentTracks.alignment).concat(this.annotationTracks)}titleSuffix(t,e){return r(this,void 0,void 0,(function*(){let e=t.target_id;if(null!=this.polymerEntityInstance&&t.source===o.Source.PdbInstance){const n=t.target_id.split(i.TagDelimiter.instance)[1],r=this.polymerEntityInstance.translateAsymToAuth(n);e=n===r?n:n+"[auth "+r+"]"}return e}))}}e.RcsbFvUniprotEntity=c},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvUniprotInstance=void 0;const o=n(7),a=n(14);class i extends a.RcsbFvAbstractModule{protectedBuild(t){return r(this,void 0,void 0,(function*(){const e=t.upAcc,n=t.entityId,r=t.instanceId,a=t.additionalConfig;let i=[o.Source.Uniprot,o.Source.PdbEntity,o.Source.PdbInstance];null!=a&&null!=a.sources&&a.sources.length>0&&(i=a.sources);let c=[{field:o.FieldName.TargetId,operation:o.OperationType.Equals,source:o.Source.PdbEntity,values:[n]},{field:o.FieldName.TargetId,operation:o.OperationType.Contains,source:o.Source.PdbInstance,values:[r]}];null!=a&&null!=a.filters&&a.filters.length>0&&(c=a.filters),this.alignmentTracks=yield this.sequenceCollector.collect({queryId:e,from:o.SequenceReference.Uniprot,to:o.SequenceReference.PdbInstance,filterByTargetContains:r,excludeFirstRowLink:!0}),this.annotationTracks=yield this.annotationCollector.collect({queryId:e,reference:o.SequenceReference.Uniprot,sources:i,filters:c,collectSwissModel:!0}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){this.rowConfigData=this.alignmentTracks.sequence.concat(this.alignmentTracks.alignment).concat(this.annotationTracks)}}e.RcsbFvUniprotInstance=i},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvUniprot=void 0;const o=n(7),a=n(14),i=n(136);class c extends a.RcsbFvAbstractModule{constructor(t,e){super(t,e),this.sequenceCollector=new i.ObservedSequenceCollector}protectedBuild(t){return r(this,void 0,void 0,(function*(){const e=t.upAcc,n=[o.Source.Uniprot];this.alignmentTracks=yield this.sequenceCollector.collect({queryId:e,from:o.SequenceReference.Uniprot,to:o.SequenceReference.PdbEntity,dynamicDisplay:!1,fitTitleWidth:!0,excludeFirstRowLink:!0}),this.annotationTracks=yield this.annotationCollector.collect({queryId:e,reference:o.SequenceReference.Uniprot,sources:n,collectSwissModel:!0}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){var e;this.rowConfigData=(null===(e=t.additionalConfig)||void 0===e?void 0:e.hideAlignments)?this.alignmentTracks.sequence.concat(this.annotationTracks):this.alignmentTracks.sequence.concat(this.annotationTracks).concat(this.alignmentTracks.alignment)}}e.RcsbFvUniprot=c},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.ObservedSequenceCollector=void 0;const o=n(7),a=n(24),i=n(137),c=n(45),s=n(10),l=n(13),u=n(29);e.ObservedSequenceCollector=class{constructor(){this.entityInstanceMap=new i.MultipleEntityInstanceTranslate,this.unObservedMap=new Map,this.sequenceCollector=new a.SequenceCollector,this.rcsbFvQuery=new l.RcsbClient}collect(t,e){return r(this,void 0,void 0,(function*(){const n=yield this.collectUnmodeledRegions(t);return this.loadObservedRegions(n),yield this.sequenceCollector.collect(t,e,this.collectEntityInstanceMap.bind(this),this.tagObservedRegions.bind(this))}))}getTargets(){return this.sequenceCollector.getTargets()}getAlignmentResponse(){return this.sequenceCollector.getAlignmentResponse()}getSequenceLength(){return this.sequenceCollector.getSequenceLength()}getPolymerEntityInstanceTranslator(){return this.polymerEntityInstanceTranslator}setPolymerEntityInstanceTranslator(t){this.sequenceCollector.setPolymerEntityInstanceTranslator(t),this.polymerEntityInstanceTranslator=t}setExternalTrackBuilder(t){this.sequenceCollector.setExternalTrackBuilder(t),this.externalTrackBuilder=t}loadObservedRegions(t){t.forEach(t=>{t.features.forEach(e=>{e.feature_positions.forEach(e=>{this.addUnmodelled(t.target_id,e.beg_seq_id,e.end_seq_id)})})})}addUnmodelled(t,e,n,r){this.unObservedMap.has(t)||this.unObservedMap.set(t,new Set),Array(n-e+1).fill(0).map((t,n)=>e+n).forEach(e=>{r&&this.unObservedMap.get(t).has(e)?this.unObservedMap.get(t).delete(e):this.unObservedMap.get(t).add(e)})}collectUnmodeledRegions(t){const e=[{field:o.FieldName.Type,operation:o.OperationType.Equals,source:o.Source.PdbInstance,values:[o.Type.UnobservedResidueXyz]}],n=[o.Source.PdbInstance];return t.group?this.rcsbFvQuery.requestRcsbPdbGroupAnnotations({groupId:t.groupId,group:t.group,sources:n,filters:e}):this.rcsbFvQuery.requestRcsbPdbAnnotations({queryId:t.queryId,reference:t.from,sources:n,filters:e})}tagObservedRegions(t,e,n){if(null!=this.entityInstanceMap.getEntity(e.targetId)){const r=this.entityInstanceMap.getEntity(e.targetId).translateEntityToAsym(e.targetId.split(s.TagDelimiter.entity)[1]),o=e.targetId.split(s.TagDelimiter.entity)[0],a=new Map;r.forEach(e=>{this.unObservedMap.has(o+s.TagDelimiter.instance+e)&&this.unObservedMap.get(o+s.TagDelimiter.instance+e).forEach(e=>{e>=t.query_begin&&e<=t.query_end&&(a.has(e)?a.set(e,a.get(e)+1):a.set(e,1))})});const i=Array.from(a.entries()).filter(t=>t[1]==r.length).map(t=>t[0]).sort((t,e)=>t-e);if(i.length>0){let r=i.shift(),o=r,a=t.target_begin-t.query_begin;const c=new Array;0==i.length&&c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0}),i.forEach((t,e)=>{t==o+1?o=t:(c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0}),r=t,o=t,e==i.length-1&&c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0}))}),o>r&&c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0});const s=new Array;t.query_begin<c[0].query_begin&&s.push({query_begin:t.query_begin,query_end:c[0].query_begin-1,target_begin:t.target_begin,target_end:c[0].target_begin-1,openBegin:!1,openEnd:!1,unModelled:!1}),s.push(Object.assign(Object.assign({},c.shift()),{openBegin:!1,openEnd:!1})),c.forEach((t,e)=>{const n=s.length-1;s.push({query_begin:s[n].query_end+1,query_end:t.query_begin-1,target_begin:s[n].target_end+1,target_end:t.target_begin-1,openBegin:!1,openEnd:!1,unModelled:!1}),s.push(Object.assign(Object.assign({},t),{openBegin:!1,openEnd:!1}))});const l=s.length-1;return s[l].query_end<t.query_end&&s.push({query_begin:s[l].query_end+1,query_end:t.query_end,target_begin:s[l].target_end+1,target_end:t.target_end,openBegin:!1,openEnd:!1,unModelled:!1}),s[0].openBegin=1!=s[0].target_begin,s[s.length-1].openEnd=s[s.length-1].target_end!=e.targetSequenceLength&&!n,s}}return[Object.assign(Object.assign({},t),{unModelled:!1})]}collectEntityInstanceMap(t){return r(this,void 0,void 0,(function*(){const e=new c.MultipleEntityInstancesCollector;(yield Promise.all(u.Operator.arrayChunk(t,100).map(t=>e.collect({entity_ids:t})))).forEach(t=>{this.entityInstanceMap.add(t)})}))}}},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MultipleEntityInstanceTranslate=void 0;const r=n(38),o=n(10),a=n(29);e.MultipleEntityInstanceTranslate=class{constructor(){this.entityInstanceTranslateMap=new Map}add(t){const e=new Map;t.forEach(t=>{const n=t.entryId+o.TagDelimiter.entity+t.entityId;e.has(n)||e.set(n,new 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o=n(10),a=n(139),i=n(7),c=n(12),s=n(55);class l{static buildEntitySummaryFv(t,e,n){return r(this,void 0,void 0,(function*(){return new Promise((p,d)=>{const h=n.split(o.TagDelimiter.entity)[0],f=n.split(o.TagDelimiter.entity)[0];c.RcsbFvCoreBuilder.getPolymerEntityInstanceMapAndCustomBuildFv(f,d=>r(this,void 0,void 0,(function*(){const f=yield c.RcsbFvCoreBuilder.createFv({elementId:t,fvModuleI:a.RcsbFvEntity,p:d,config:{entityId:n,elementSelectId:e,additionalConfig:Object.assign({rcsbContext:{entryId:n.split(o.TagDelimiter.entity)[0],entityId:n.split(o.TagDelimiter.entity)[1]}},u()),resolve:p}}),m=yield f.getTargets();return c.RcsbFvCoreBuilder.buildSelectButton(t,e,[n].concat(m).map(e=>({label:e,onChange:()=>r(this,void 0,void 0,(function*(){e===n?yield l.buildSingleEntitySummaryFv(t,n):yield s.RcsbFvUniprotBuilder.buildUniprotEntityFv(t,e,n,u({field:i.FieldName.TargetId,operation:i.OperationType.Contains,source:i.Source.PdbInstance,values:[h]}))}))}))),f})))})}))}static buildSingleEntitySummaryFv(t,e){return r(this,void 0,void 0,(function*(){return new Promise((n,r)=>{const i=e.split(o.TagDelimiter.entity)[0];c.RcsbFvCoreBuilder.getPolymerEntityInstanceMapAndBuildFv(t,i,a.RcsbFvEntity,{entityId:e,additionalConfig:Object.assign({rcsbContext:{entryId:e.split(o.TagDelimiter.entity)[0],entityId:e.split(o.TagDelimiter.entity)[1]}},u()),resolve:n})})}))}static buildEntityFv(t,e,n){return r(this,void 0,void 0,(function*(){return new Promise((r,i)=>{const s=e.split(o.TagDelimiter.entity)[0];c.RcsbFvCoreBuilder.getPolymerEntityInstanceMapAndBuildFv(t,s,a.RcsbFvEntity,{entityId:e,additionalConfig:Object.assign({rcsbContext:{entryId:e.split(o.TagDelimiter.entity)[0],entityId:e.split(o.TagDelimiter.entity)[1]}},n),resolve:r})})}))}}function u(t){const e=[{field:i.FieldName.Type,operation:i.OperationType.Equals,source:i.Source.PdbInstance,values:[i.Type.UnobservedResidueXyz,i.Type.UnobservedAtomXyz]}];return t&&e.push(t),{sources:[i.Source.PdbEntity,i.Source.PdbInstance],filters:e}}e.RcsbFvEntityBuilder=l},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvEntity=void 0;const o=n(7),a=n(14),i=n(10);class c extends a.RcsbFvAbstractModule{protectedBuild(t){var e,n;return r(this,void 0,void 0,(function*(){const r=t.entityId,a=(null===(e=t.additionalConfig)||void 0===e?void 0:e.filters)?t.additionalConfig.sources:[o.Source.PdbEntity,o.Source.Uniprot];this.alignmentTracks=yield this.sequenceCollector.collect({queryId:r,from:o.SequenceReference.PdbEntity,to:o.SequenceReference.Uniprot}),this.annotationTracks=yield 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0:e.hideAlignments)?this.alignmentTracks.sequence.concat(this.annotationTracks):this.alignmentTracks.sequence.concat(this.alignmentTracks.alignment).concat(this.annotationTracks)}}e.RcsbFvInstance=i},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvProteinSequenceBuilder=void 0;const o=n(7),a=n(142),i=n(12);e.RcsbFvProteinSequenceBuilder=class{static buildPfv(t,e){var n;return r(this,void 0,void 0,(function*(){const r=null!==(n=e.alignmentSource)&&void 0!==n?n:e.reference,c=[o.Source.Uniprot];return 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sapiens",assemblies:{default:"GCF_000001405.26",GRCh38:"GCF_000001405.26",GRCh37:"GCF_000001405.13",NCBI36:"GCF_000001405.12"}},10090:{commonName:"Mouse",scientificName:"Mus musculus",assemblies:{default:"GCF_000001635.20",GRCm38:"GCF_000001635.20",MGSCv37:"GCF_000001635.18"}},9598:{commonName:"Chimpanzee",scientificName:"Pan troglodytes",assemblies:{default:"GCF_000001515.7","Pan_tro 3.0":"GCF_000001515.7"}},10116:{commonName:"Rat",scientificName:"Rattus norvegicus",assemblies:{default:"GCF_000001895.5","Rnor_6.0":"GCF_000001895.5"}},3702:{commonName:"Thale cress",scientificName:"Arabidopsis thaliana",assemblies:{default:"GCF_000001735.3",TAIR10:"GCF_000001735.3"}},4530:{commonName:"Rice",scientificName:"Oryza sativa",assemblies:{default:"GCA_001433935.1","IRGSP-1.0":"GCA_001433935.1"}},4577:{commonName:"Maize",scientificName:"Zea mays",assemblies:{default:"GCA_000005005.5","IRGSP-1.0":"GCA_001433935.1"}},4641:{commonName:"Banana",scientificName:"Musa acuminata",assemblies:{default:"mock"}},7227:{commonName:"Fly",scientificName:"Drosophila melanogaster",assemblies:{default:"GCA_000001215.4","Release 6 plus ISO1 MT":"GCA_000001215.4"}},7165:{commonName:"Mosquito",scientificName:"Anopheles gambiae",assemblies:{default:""}},746128:{commonName:"Aspergillis fumigatus",scientificName:"Aspergillis fumigatus",assemblies:{default:""}},227321:{commonName:"Aspergillus nidulans",scientificName:"",assemblies:{default:""}},5061:{commonName:"black mold",scientificName:"Aspergillus niger",assemblies:{default:""}},5062:{commonName:"koji",scientificName:"Aspergillus oryzae",assemblies:{default:""}},15368:{commonName:"",scientificName:"Brachypodium distachyon",assemblies:{default:""}},60711:{commonName:"",scientificName:"Chlorocebus sabaeus",assemblies:{default:""}},7719:{commonName:"Vase tunicate",scientificName:"Ciona intestinalis",assemblies:{default:""}},9685:{commonName:"Cat",scientificName:"Felis catus",assemblies:{default:""}},9031:{commonName:"Chicken",scientificName:"Gallus gallus",assemblies:{default:""}},9593:{commonName:"Gorilla",scientificName:"Gorilla gorilla",assemblies:{default:""}},4513:{commonName:"Barley",scientificName:"Hordeum vulgare",assemblies:{default:""}},9541:{commonName:"Crab-eating macaque",scientificName:"Macaca fascicularis",assemblies:{default:""}},9544:{commonName:"Rhesus macaque",scientificName:"Macaca mulatta",assemblies:{default:""}},9597:{commonName:"Bonobo",scientificName:"Pan paniscus",assemblies:{default:""}},9615:{commonName:"Dog",scientificName:"Canis lupus familiaris",assemblies:{default:""}},4932:{commonName:"Yeast",scientificName:"Saccharomyces cerevisiae",assemblies:{default:"GCA_000146045.2",R64:"GCA_000146045.2"}},5833:{commonName:"malaria parasite",scientificName:"Plasmodium falciparum",assemblies:{default:"GCA_000002765.3",GCA_000002765:"GCA_000002765.3"}},6239:{commonName:"worm",scientificName:"Caenorhabditis elegans",assemblies:{default:"GCF_000002985.6",GCA_000002765:"GCF_000002985.6"}}};Qo=[["gneg","#FFF","#FFF","#DDD"],["gpos25","#C8C8C8","#DDD","#BBB"],["gpos33","#BBB","#BBB","#AAA"],["gpos50","#999","#AAA","#888"],["gpos66","#888","#888","#666"],["gpos75","#777","#777","#444"],["gpos100","#444","#666","#000"],["acen","#FEE","#FEE","#FDD"],["noBands","#BBB","#BBB","#AAA"]];let Ko='#_ideogram {padding-left: 5px;} #_ideogram .labeled {padding-left: 15px;} #_ideogram.labeledLeft {padding-left: 15px; padding-top: 15px;} #_ideogram text {font: 9px Tahoma; fill: #000;} #_ideogram .italic {font-style: italic;} #_ideogram .chromosome {cursor: pointer; fill: #AAA;}#_ideogram.no-rotate .chromosome {cursor: default;} #_ideogram .chrLabel, #_ideogram .annot {cursor: pointer;}#_ideogram .chrSetLabel {font-weight: bolder;}#_ideogram .ghost {opacity: 0.2;}#_ideogram .hidden {display: none;}#_ideogram .bandLabelStalk line {stroke: #AAA; stroke-width: 1;}#_ideogram .syntenyBorder 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#EEF}#_ideogram .gneg {fill: url("#gneg")} #_ideogram .gpos25 {fill: url("#gpos25")} #_ideogram .gpos33 {fill: url("#gpos33")} #_ideogram .gpos50 {fill: url("#gpos50")} #_ideogram .gpos66 {fill: url("#gpos66")} #_ideogram .gpos75 {fill: url("#gpos75")} #_ideogram .gpos100 {fill: url("#gpos100")} #_ideogram .gpos {fill: url("#gpos100")} #_ideogram .acen {fill: url("#acen")} #_ideogram .stalk {fill: url("#stalk")} #_ideogram .gvar {fill: url("#gvar")} #_ideogram .noBands {fill: url("#noBands")} #_ideogram .chromosome {fill: url("#noBands")} ';function $o(t){var e;this.config=JSON.parse(JSON.stringify(t)),(e=this).chromosomesArray=[],e.coordinateSystem="iscn",e.maxLength={bp:0,iscn:0},e.chromosomes={},e.numChromosomes=0,e.config.debug||(e.config.debug=!1),e.config.dataDir||(e.config.dataDir=e.getDataDir()),e.config.container||(e.config.container="body"),e.selector=e.config.container+" #_ideogram",e.config.resolution||(e.config.resolution=""),e.config.orientation||(e.config.orientation="vertical"),e.config.brush||(e.config.brush=null),e.config.rows||(e.config.rows=1),"showChromosomeLabels"in e.config==0&&(e.config.showChromosomeLabels=!0),e.config.showNonNuclearChromosomes||(e.config.showNonNuclearChromosomes=!1),e.config.chromosomeScale||(e.config.chromosomeScale="absolute"),e.config.showTools||(e.config.showTools=!1),function(t){t.config.ploidy||(t.config.ploidy=1),t.config.ploidy>1&&(t.sexChromosomes={},t.config.sex||(t.config.sex="male"),2!==t.config.ploidy||t.config.ancestors||(t.config.ancestors={M:"#ffb6c1",P:"#add8e6"},t.config.ploidyDesc="MP"))}(this),function(t){t.config.showBandLabels||(t.config.showBandLabels=!1),"showFullyBanded"in t.config==!1&&(t.config.showFullyBanded=!0),t.bandsToShow=[],t.bandData={}}(this),function(t){var e,n,r;t.config.chrHeight||(e=t.config.container,n=document.querySelector(e).getBoundingClientRect(),r="vertical"===t.config.orientation?n.height:n.width,"body"!==e&&0!==r||(r=400),t.config.chrHeight=r)}(this),function(t){var e,n;t.config.chrWidth||(e=10,(n=t.config.chrHeight)<900&&n>500?e=Math.round(n/40):n>=900&&(e=Math.round(n/45)),t.config.chrWidth=e)}(this),function(t){t.config.geometry&&"collinear"===t.config.geometry?"chrMargin"in t.config==!1&&(t.config.chrMargin=0):(t.config.chrMargin||(1===t.config.ploidy?t.config.chrMargin=10:t.config.chrMargin=Math.round(t.config.chrWidth/4)),t.config.showBandLabels&&(t.config.chrMargin+=20))}(this),function(t,e){t.onLoad&&(e.onLoadCallback=t.onLoad),t.onLoadAnnots&&(e.onLoadAnnotsCallback=t.onLoadAnnots),t.onDrawAnnots&&(e.onDrawAnnotsCallback=t.onDrawAnnots),t.onBrushMove&&(e.onBrushMoveCallback=t.onBrushMove),t.onCursorMove&&(e.onCursorMoveCallback=t.onCursorMove),t.onDidRotate&&(e.onDidRotateCallback=t.onDidRotate),t.onWillShowAnnotTooltip&&(e.onWillShowAnnotTooltipCallback=t.onWillShowAnnotTooltip),t.onClickAnnot&&(e.onClickAnnotCallback=t.onClickAnnot)}(t,this),function(t){t.organisms=Object.assign({},Yo),t.organismsWithBands=Object.assign({},t.organisms)}(this),function(t){t.bump=Math.round(t.config.chrHeight/125),t.adjustedBump=!1,t.config.chrHeight<200&&(t.adjustedBump=!0,t.bump=4)}(this),function(t,e){t.chromosome&&(e.config.chromosomes=[t.chromosome],"showBandLabels"in t==!1&&(e.config.showBandLabels=!0),"rotatable"in t==!1&&(e.config.rotatable=!1))}(t,this),function(t){const e=t.config;e.chrLabelSize||(t.config.chrLabelSize=9),e.chrLabelColor||(t.config.chrLabelColor="#000");const n=`font-size: ${e.chrLabelSize}px`,r=`fill: ${e.chrLabelColor}`;Ko+=`#_ideogram text {${n}; ${r};}`}(this),this.initAnnotSettings(),this.config.geometry&&"parallel"!==this.config.geometry||(this.config.chrMargin+=this.config.chrWidth,"heatmap"===this.config.annotationsLayout?this.config.chrMargin+=this.config.annotTracksHeight:this.config.chrMargin+=2*this.config.annotTracksHeight),this.init()}function Xo(t,e,n,r){var o,a,i,c,s,l,u,p=r.config,d=p.chrLabelSize;for(o=0;o<t.length;o++){if(a=t[o],i=e[o]+23-d,l=r.chromosomesArray[o].id.split("-")[1],s=n-200*(u=r.config.taxids.indexOf(l))-30,0===u?(c=-34,s+=2*r.config.chrWidth-16):c=2*r.config.chrWidth-24,p.showChromosomeLabels){const t=a.querySelector(".chrLabel > tspan");t.setAttribute("x",c),t.setAttribute("dy",d-8),a.querySelector(".chrLabel").setAttribute("text-anchor","start")}a.setAttribute("transform","rotate(90) translate("+i+","+s+")"),a.querySelector(".chromosome").setAttribute("transform","translate(-13, 10)")}!function(t){t.config.taxids.forEach((e,n)=>{var r=t.organisms[e].scientificName;To.select(t.selector).append("text").attr("class","genomeLabel italic").attr("x",50+200*n).attr("y",10).text(r).attr("text-anchor","middle")})}(r)}var Zo=function(t){var e,n,r,o,a=t.config;if(t.config.annotLabelHeight=12,"demarcateCollinearChromosomes"in t.config==!1&&(t.config.demarcateCollinearChromosomes=!0),-40,Xo(e=document.querySelectorAll(".chromosome-set"),n=function(t,e){var n,r,o,a,i,c,s,l={};for(n=[],r=0;r<t.length;r++)s=e.chromosomesArray[r].id.split("-")[1],o=0===r?r:r-1,a=e.chromosomesArray[o],0===r||s in l==!1?(i=20,l[s]=1):(c=a.width,i=n[o]+c+(e.config.showChromosomeLabels?0:2)+e.config.chrMargin),n.push(i);return n}(e,t),-40,t),o=Math.round(n.slice(-1)[0]+70),a.multiorganism){r*=8;var i=0;n.forEach(t=>{t>i&&(i=t)}),r=i+30}else r=xOffsets.slice(-1)[0]+30;To.select(t.selector).attr("height",r).attr("width",o),To.select("#_ideogramTrackLabelContainer").remove(),To.select("#_ideogramInnerWrap").insert("div",":first-child").attr("id","_ideogramTrackLabelContainer").style("position","absolute")};function Jo(t,e,n,r){var o,a,i,c,s,l,u,p=r.config,d=p.chrWidth,h=p.chrLabelSize;for(o=0;o<t.length;o++)a=t[o],c=e[o],i=r.chromosomesArray[o].id.split("-")[1],s=n+200*(l=p.taxids.indexOf(i)),0===l&&r.config.multiorganism?(u=h-4,s+=2*d+h):u=2*d+h+2,r.config.showChromosomeLabels&&(a.querySelector(".chrLabel").setAttribute("y",u),a.querySelector(".chrLabel").setAttribute("text-anchor","middle")),a.setAttribute("transform","translate("+c+","+s+")"),a.querySelector(".chromosome").setAttribute("transform","translate(-13, 10)");p.multiorganism&&function(t){t.config.taxids.forEach((e,n)=>{var r=t.organisms[e],o=t.config,a=r.scientificName;To.select(t.selector).append("text").attr("class","genomeLabel italic").attr("x",5).attr("y",o.chrLabelSize+(200+3*o.chrWidth)*n).text(a)})}(r)}var ta=function(t){var e,n,r,o,a,i=t.config,c=i.annotationHeight||0;if("vertical"!==i.orientation){t.config.annotLabelHeight=12;var s=t.config.annotLabelHeight;if("demarcateCollinearChromosomes"in t.config==!1&&(t.config.demarcateCollinearChromosomes=!0),e=document.querySelectorAll(".chromosome-set"),r=i.numAnnotTracks*(c+s+4)-i.chrWidth+1,Jo(e,n=function(t,e){var n,r,o,a,i,c,s,l={};for(n=[],r=0;r<t.length;r++)s=e.chromosomesArray[r].id.split("-")[1],o=0===r?r:r-1,a=e.chromosomesArray[o],0===r||s in l==!1?(i=20,l[s]=1):(c=a.width,i=n[o]+c+(e.config.showChromosomeLabels?0:2)+e.config.chrMargin),n.push(i);return n}(e,t),r,t),o=r+2*i.chrWidth+20,i.multiorganism){o*=8;var l=0;n.forEach(t=>{t>l&&(l=t)}),a=l+20}else a=n.slice(-1)[0]+20;To.select(t.selector).attr("width",a).attr("height",o),To.select("#_ideogramTrackLabelContainer").remove(),To.select("#_ideogramInnerWrap").insert("div",":first-child").attr("id","_ideogramTrackLabelContainer").style("position","absolute")}else Zo(t)};function ea(t){void 0!==t.timeout&&window.clearTimeout(t.timeout),t.rawAnnots=t.setOriginalTrackIndexes(t.rawAnnots),t.config.annotationsDisplayedTracks?t.annots=t.updateDisplayedTracks(t.config.annotationsDisplayedTracks):(t.annots=t.processAnnotData(t.rawAnnots),t.config.filterable&&t.initCrossFilter(),t.drawProcessedAnnots(t.annots))}function na(t){var e=(new Date).getTime(),n=this.config,r=n.annotations;this.initDrawChromosomes(),n.annotationsPath&&function(t){t.rawAnnots?ea(t):function e(){t.timeout=setTimeout((function(){!t.rawAnnots||t.rawAnnots&&void 0!==t.rawAnnots.then?e():ea(t)}),50)}()}(this),function(t,e){var n,r,o,a;if(!0===t.showBandLabels&&(o=(new Date).getTime(),e.hideUnshownBandLabels(),a=(new Date).getTime(),t.debug&&console.log("Time in showing bands: "+(a-o)+" ms"),"vertical"===t.orientation))for(n=0;n<e.chromosomesArray.length;n++)r="#"+e.chromosomesArray[n].id,e.rotateChromosomeLabels(To.select(r),n);!0===t.showChromosomeLabels&&e.drawChromosomeLabels(e.chromosomes)}(n,this),n.brush?this.createBrush(n.brush):n.cursorPosition&&this.createClickCursor(n.cursorPosition),r&&(Array.isArray(r)?this.drawAnnots(r):(this.rawAnnots=r,this.afterRawAnnots(),ea(this))),function(t,e,n){var r=(new Date).getTime();t.debug&&console.log("Time in drawChromosome: "+(r-n)+" ms");var o=(new Date).getTime();t.debug&&console.log("Time constructing ideogram: "+(o-e)+" ms")}(n,t,e),this.setOverflowScroll(),"collinear"===n.geometry&&ta(this),this.onLoadCallback&&this.onLoadCallback()}class ra{constructor(t){this._config=t,this._description=this._normalize(this._config.ploidyDesc)}getChromosomesNumber(t){if(this._config.ploidyDesc){var e=this._config.ploidyDesc[t];return e instanceof Object?Object.keys(e)[0].length:e.length}return this._config.ploidy||1}_normalize(t){var e,n,r=[];if(!t)return t;for(e in t)"string"==typeof(n=t[e])?("vertical"===this._config.orientation&&(n=n.split("").reverse()),r.push({ancestors:n,existence:this._getexistenceArray(n.length)})):r.push({ancestors:Object.keys(n)[0],existence:n[Object.keys(n)[0]]});return r}_getexistenceArray(t){for(var e=[],n=0;n<t;n++)e.push("11");return e}getSetSize(t){return this._description?this._description[t].ancestors.length:1}getAncestor(t,e){return this._description?this._description[t].ancestors[e]:""}exists(t,e,n){if(this._description){var r=this._description[t].existence[e][n];return Number(r)>0}return!0}}class oa{constructor(t){this._node=t}getLabel(){return To.select(this._node.parentNode).select("text.chrLabel").text()}getSetLabel(){return To.select(this._node.parentNode).select("text.chrSetLabel").text()}}var aa=class{constructor(t,e){if(this._config=t,this._ideo=e,this._ploidy=this._ideo._ploidy,this._translate=void 0,"chrSetMargin"in t)this.chrSetMargin=t.chrSetMargin;else{var n=this._config.chrMargin;this.chrSetMargin=this._config.ploidy>1?n:0}this._tickSize=8,this._isRotated=!1}_getLeftMargin(){return this.margin.left}_getYScale(){return 20/this._config.chrWidth}getChromosomeLabels(t){var e=new oa(t),n=[];return this._ideo.config.ploidy>1&&n.push(e.getSetLabel()),n.push(e.getLabel()),n.filter((function(t){return t.length>0}))}getChromosomeBandLabelTranslate(t){var e,n,r,o=this._ideo,a=this._tickSize,i=o.config.orientation;return"vertical"===i?r="rotate(-90)translate("+(e=a)+","+(n=o.round(2+t.px.start+t.px.width/2))+")":"horizontal"===i&&(r="translate("+(e=o.round(-a+t.px.start+t.px.width/2))+","+(n=-10)+")"),{x:e,y:n,translate:r}}didRotate(t,e){var n,r,o,a,i,c,s,l,u;r=(n=this._ideo).config.taxid,o=e.id.split("-")[0].replace("chr",""),a=(i=n.chromosomes[r][o]).bands,l=(s=To.select(e.parentNode)).attr("transform"),u=/scale\(.*\)/.exec(l),l=l.replace(u,""),s.attr("transform",l),c=i.width,(i=n.getChromosomeModel(a,o,r,t)).oldWidth=c,n.chromosomes[r][o]=i,n.drawChromosome(i),n.handleRotateOnClick(),n.rawAnnots&&(n.displayedTrackIndexes?n.updateDisplayedTracks(n.displayedTrackIndexes):(n.annots=n.processAnnotData(n.rawAnnots),n.drawProcessedAnnots(n.annots),n.config.filterable&&n.initCrossFilter())),!0===n.config.showBandLabels&&(n.drawBandLabels(n.chromosomes),n.hideUnshownBandLabels()),n.onDidRotateCallback&&n.onDidRotateCallback(i)}rotate(t,e,n){var r,o,a,i;r=this._ideo,i=r.selector+" .chrSetLabel, "+r.selector+" .chrLabel",a=document.querySelector(r.selector).getBoundingClientRect(),o=To.selectAll(r.selector+" g.chromosome").filter((function(){return this!==n})),this._isRotated?(this._isRotated=!1,r.config.chrHeight=r.config.chrHeightOriginal,r.config.chrWidth=r.config.chrWidthOriginal,r.config.annotationHeight=r.config.annotationHeightOriginal,this.rotateBack(t,e,n,(function(){o.style("display",null),To.selectAll(i).style("display",null),r._layout.didRotate(e,n)}))):(this._isRotated=!0,o.style("display","none"),To.selectAll(i).style("display","none"),this.rotateForward(t,e,n,(function(){var t,o,i;r.config.chrHeightOriginal=r.config.chrHeight,r.config.chrWidthOriginal=r.config.chrWidth,r.config.annotationHeightOriginal=r.config.annotationHeight;"VerticalLayout"===r._layout._class?(o=a.width-20,i=window.innerWidth-20):(o=a.height-10,i=window.innerHeight-10),t=i<o?i:o,t-=2*r.config.chrMargin,r.config.chrHeight=t,r.config.chrWidth*=2.3,r.config.annotationHeight*=1.7,r._layout.didRotate(e,n)})))}getChromosomeLabelClass(){return 1===this._config.ploidy?"chrLabel":"chrSetLabel"}_getAdditionalOffset(){var t=this._config,e=t.annotationsNumTracks||t.numAnnotTracks||1;return(t.annotationHeight||0)*e}_getChromosomeSetSize(t){return this._ploidy.getSetSize(t)*this._config.chrWidth*2+this.chrSetMargin}getChromosomeSetLabelAnchor(){return"middle"}getChromosomeLabelYPosition(){return-5.5}getChromosomeSetLabelYPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelYPosition(t):-2*this._config.chrWidth}};var ia=class extends aa{constructor(t,e){super(t,e),this._class="VerticalLayout",this.margin={top:30,left:15}}rotateForward(t,e,n,r){var o="translate(20, 25) "+this.getChromosomeScale(n);To.select(n.parentNode).transition().attr("transform",o).on("end",r);var a=this.getChromosomeLabels(n),i=1.3*(20+this._config.chrWidth);To.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(a).enter().append("text").attr("class",(function(t,e){return 0===e&&2===a.length?"chrSetLabel":null})).attr("x",0).attr("y",i).style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="horizontal"}rotateBack(t,e,n,r){var o=this.getChromosomeScaleBack(n),a=this.getChromosomeSetTranslate(t);To.select(n.parentNode).transition().attr("transform",a+" "+o).on("end",r),To.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="vertical"}getHeight(){return this._config.chrHeight+1.5*this.margin.top}getWidth(){return"97%"}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeBandLabelAnchor(){return null}getChromosomeScale(t){var e,n;return e=To.select(this._ideo.selector).node().getBoundingClientRect(),n=t.getBoundingClientRect(),"scale("+e.width/n.height*.97+", "+this._getYScale()+")"}getChromosomeScaleBack(t){var e,n,r;return n=(r=this._ideo.config).taxid,e=t.id.split("-")[0].replace("chr",""),"scale("+this._ideo.chromosomes[n][e].oldWidth/(3*r.chrHeight)*.97+", "+1/this._getYScale()+")"}getChromosomeSetTranslate(t){return"rotate(90) translate("+this.margin.top+", -"+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){var e,n=this._getAdditionalOffset(),r=this._config.chrMargin,o=this._config.chrWidth;if(!this._config.ploidyDesc)return"histogram"===this._config.annotationsLayout?r+t*(r+o+3)+2*this._ideo.config.barWidth:(e=o+t*(r+o)+2*n,n>0?e:e+4+2*t);if(!this._translate){var a;this._translate=[this._ploidy.getSetSize(0)*o*2];for(var i=1;i<this._config.ploidyDesc.length;i++)a=this._translate[i-1],this._translate[i]=a+this._getChromosomeSetSize(i-1)}return this._translate[t]}getChromosomeSetLabelXPosition(){return this._config.chrWidth*this._config.ploidy/-2}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}};var ca=class extends aa{constructor(t,e){super(t,e),this._class="HorizontalLayout",this.margin={left:20,top:30}}_getLeftMargin(){var t=aa.prototype._getLeftMargin.call(this);return this._config.ploidy>1&&(t*=1.8),t}rotateForward(t,e,n,r){var o;To.select(n.parentNode).transition().attr("transform","rotate(90) translate(30, -37.5) ").on("end",r),o=this.getChromosomeLabels(n),To.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(o).enter().append("text").attr("class",(function(t,e){return 0===e&&2===o.length?"chrSetLabel":null})).attr("x",26).attr("y",(function(t,e){return 12*(e+1+o.length%2)})).style("text-anchor","middle").style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="vertical"}rotateBack(t,e,n,r){var o=this.getChromosomeSetTranslate(t);To.select(n.parentNode).transition().attr("transform",o).on("end",r),To.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="horizontal"}getHeight(t){void 0===t&&(t=this._config.taxids[0]);var e=this._config.chromosomes[t].length,n=this.getChromosomeSetYTranslate(e-1);return(n+=this._getChromosomeSetSize(e-1))+2*this._getAdditionalOffset()}getWidth(){return this._config.chrHeight+1.5*this.margin.top}getChromosomeSetLabelAnchor(){return"end"}getChromosomeBandLabelAnchor(){return null}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return null}getChromosomeSetTranslate(t){return"translate("+this._getLeftMargin()+", "+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){if(!this._config.ploidyDesc)return this._config.chrMargin*(t+1);if(!this._translate){this._translate=[1];for(var e=1;e<this._config.ploidyDesc.length;e++)this._translate[e]=this._translate[e-1]+this._getChromosomeSetSize(e-1)}return this._translate[t]}getChromosomeSetLabelXPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelXPosition(t):-20}getChromosomeSetLabelYPosition(t){var e=this._ploidy.getSetSize(t),n=this._config,r=n.chrMargin,o=n.chrWidth;return 1===n.ploidy?o/2+3:e*r/2}getChromosomeLabelXPosition(){return-8}getChromosomeLabelYPosition(){return this._config.chrWidth}};var sa=class extends aa{constructor(t,e){super(t,e),this._class="PairedLayout",this.margin={left:30}}getHeight(){return this._config.chrHeight+1.5*this.margin.left}getWidth(){return"97%"}getChromosomeBandTickY1(t){return t%2?this._config.chrWidth:2*this._config.chrWidth}getChromosomeBandTickY2(t){var e=this._config.chrWidth;return t%2?e-this._tickSize:2*e+this._tickSize}getChromosomeBandLabelAnchor(t){return t%2?null:"end"}getChromosomeBandLabelTranslate(t,e){var n=e%2?10:-this._config.chrWidth-10,r=this._ideo.round(t.px.start+t.px.width/2)+3;return{x:r,y:r,translate:"rotate(-90) translate("+n+", "+r+")"}}getChromosomeLabelXPosition(){return-this._tickSize}getChromosomeSetLabelXPosition(){return this._config.chrWidth/-2}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var e=this.getChromosomeSetYTranslate(t);return"rotate(90) translate("+this.margin.left+", -"+e+")"}getChromosomeSetYTranslate(t){return 200*(t+1)}};var la=class extends aa{constructor(t,e){super(t,e),this._class="SmallLayout",this.margin={left:36.5,top:10};var n=this._ideo.getTaxid(this._ideo.config.organism);this.chrs=t.chromosomes[n];var r=this.chrs.length;this.chrsPerRow=Math.ceil(r/t.rows)}getHeight(){var t=1.25*this._config.chrHeight;return this._config.rows*(t+this.margin.top)}getWidth(){return"97%"}getChromosomeBandLabelTranslate(){}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var e,n;return t>this.chrsPerRow-1?(e=this.margin.left+1.3*this._config.chrHeight,n=this.getChromosomeSetYTranslate(t-this.chrsPerRow)):(e=this.margin.left,n=this.getChromosomeSetYTranslate(t)),"rotate(90) translate("+e+", -"+n+")"}getChromosomeSetYTranslate(t){var e=.3*this._getAdditionalOffset();return this.margin.left*t+this._config.chrWidth+2*e+e*t}getChromosomeSetLabelXPosition(t){return(this._ploidy.getSetSize(t)*this._config.chrWidth+20)/-2+(this._config.ploidy>1?0:this._config.chrWidth)}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}};function ua(t){this.config.annotationsPath&&this.fetchAnnots(this.config.annotationsPath),function(t){if("ploidyDesc"in t.config&&"string"==typeof t.config.ploidyDesc){for(var e=[],n=0;n<t.numChromosomes;n++)e.push(t.config.ploidyDesc);t.config.ploidyDesc=e}t._ploidy=new ra(t.config)}(this),this._layout=function(t){var e=t.config;return"perspective"in e&&"comparative"===e.perspective?new sa(e,t):"rows"in e&&e.rows>1?new la(e,t):"vertical"===e.orientation?new ia(e,t):"horizontal"===e.orientation?new ca(e,t):new ia(e,t)}(this),function(t){To.selectAll(t.config.container+" #_ideogramOuterWrap").remove(),To.select(t.config.container).append("div").attr("id","_ideogramOuterWrap").append("div").attr("id","_ideogramTrackLabelContainer").style("position","absolute"),To.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("id","_ideogramMiddleWrap").style("position","relative").style("overflow-x","auto").style("transform","translateZ(0)").append("div").attr("id","_ideogramInnerWrap").append("svg").attr("id","_ideogram").attr("class",function(t){var e="";return t.config.showChromosomeLabels&&("horizontal"===t.config.orientation?e+="labeledLeft ":e+="labeled "),!1===t.config.rotatable&&(e+="no-rotate "),t.config.annotationsLayout&&"overlay"===t.config.annotationsLayout&&(e+="faint"),e}(t)).attr("width",t._layout.getWidth()).attr("height",t._layout.getHeight()).html(t.getBandColorGradients())}(this),this.isOnlyIdeogram=1===document.querySelectorAll("#_ideogram").length,function(t){To.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("class","_ideogramTooltip").attr("id","_ideogramTooltip").style("opacity",0).style("position","fixed").style("text-align","center").style("padding","4px").style("font","12px sans-serif").style("background","white").style("border","1px solid black").style("border-radius","5px").style("z-index","1000")}(this),this.finishInit(t)}var pa="";function da(t,e,n){return n.config.dataDir+t[e]}function ha(t,e,n){var r=n.config.ploidy;return"sex"in n.config&&(2===r&&n.sexChromosomes.index+1===e||"female"===n.config.sex&&"Y"===t.name)}function fa(t,e,n,r){var o,a,i,c,s;for(o=0;o<e.length;o++)i=e[o],void 0!==t&&(a=t[o]),s=o+r.config.taxids.indexOf(n),c=r.getChromosomeModel(a,i,n,s),"string"!=typeof i&&(i=i.name.split(" ").slice(-1)[0].replace("chr","")),r.chromosomes[n][i]=c,r.chromosomesArray.push(c),ha(c,o,r)||r.drawChromosome(c)}function ma(t,e){"undefined"!=typeof chrBands&&t.length>=chrBands.length/2&&(e.coordinateSystem="bp")}function ga(){var t,e,n,r,o=this.config.taxids;for(e=0;e<o.length;e++)t=o[e],n=this.config.chromosomes[t],r=this.bandsArray[t],this.config.showNonNuclearChromosomes||(n=n.filter(t=>"MT"!==t),void 0!==r&&(r=r.filter(t=>"MT"!==t[0].chr))),ma(n,this),this.chromosomes[t]={},this.setSexChromosomes(n),fa(r,n,t,this),this.config.showBandLabels&&this.drawBandLabels(this.chromosomes),this.handleRotateOnClick(),this._gotChrModels=!0}function va(){var t=this;"rotatable"in t.config&&!1===t.config.rotatable?To.selectAll(t.selector).style("cursor","default"):To.selectAll(t.selector+" .chromosome-set").on("click",(function(){const e=this.children[1];t.rotateAndToggleDisplay(e)}))}function ba(){call(this.onLoadCallback)}function ya(t,e,n){var r=n.organisms[t],o=[Po(r.scientificName)],a=r.assemblies,i=n.config.resolution;e!==a.default&&o.push(e),"9606"===t&&(e in a==="false"&&Object.values(a).includes(config.assembly)||""!==i&&850!==i)&&o.push(i),o=o.join("-");return["9606","10090","10116"].includes(t)&&!n.config.showFullyBanded&&(o+="-no-bands"),o+=".json"}function Sa(t,e,n){var r,o,a,i=n.config;return r=n.organisms[t],i.assembly||(n.config.assembly="default"),o=r.assemblies,a=ya(t,n.assemblyIsAccession()?i.assembly:o[i.assembly],n),t in n.organismsWithBands&&(e[t]=a),e}function Ca(t,e,n,r){return function(t,e,n){var r=da(t,e,n);return(!(void 0!==window.chrBands&&""===pa)||pa!==r)&&function(t){return"assembly"in t.config&&!1===/(GCA_)/.test(t.config.assembly)}(n)&&e in t}(e,t,r)?function(t,e,n,r){var o=da(t,e,r);return r.numBandDataResponses||(r.numBandDataResponses=0),fetch(o).then((function(e){return e.json().then((function(n){pa=o,delete window.chrBands,window.chrBands=n.chrBands,function(t,e,n,r){var o,a,i;for(o in e)i=e[o],t.includes(i)&&""!==i&&(a=o);r.bandData[a]=n}(e.url,t,chrBands,r)}))}))}(e,t,0,r).then((function(){return r.processBandData(t)})):new Promise((function(e){r.processBandData(t),e([t,void 0])}))}var xa={},_a={},wa={};function za(t){var e=(t=t||this).config.container;wa[e]?(_a[e]=!0,xa[e]=t):(wa[e]=!0,function(t){return new Promise((function(e){if("number"==typeof t.config.organism){var n=t.config.organism;t.getOrganismFromEutils(n,(function(){t.getTaxids(e)}))}else t.getTaxids(e)}))}(t).then((function(n){var r=n[0];t.config.taxid=r,t.config.taxids=n,function(t,e,n){var r,o,a,i=[];for(a in r={},Yo)r[a]="";for(o=0;o<t.length;o++)r=Sa(a=String(t[o]),r,n),i.push(Ca(a,r,0,n));Promise.all(i).then((function(t){var r,a,i;for(o=0;o<t.length;o++)a=(r=t[o])[0],i=r[1],"bandsArray"in n==!1&&(n.bandsArray={}),n.bandsArray[a]=i;n.writeContainer(e)}))}(n,(new Date).getTime(),t),wa[e]=!1,_a[e]&&(_a[e]=!1,za(xa[e]))})))}class Ea{constructor(t,e){this.rawAnnots=this.parseBed(t,e)}static componentToHex(t){var e=parseInt(t,10).toString(16);return 1===e.length?"0"+e:e}static rgbToHex(t,e,n){return"#"+Ea.componentToHex(t)+Ea.componentToHex(e)+Ea.componentToHex(n)}parseGenomicCoordinates(t,e){var n,r,o,a;return n=t[0],r=parseInt(t[1],10),a=(o=parseInt(t[2],10))-r,e&&(n=n.slice(3)),[n,r,o,a]}parseAnnotFromTsvLine(t,e,n){var r,o,a,i,c,s,l,u=t.split(/\s/g);return[a,i,stop,length]=this.parseGenomicCoordinates(u,n),-1===(o=e.indexOf(a))?[null,null]:(r=["",i,length,0],u.length>=4&&(l=u[3],r[0]=l),u.length>=8&&(c=u[8].split(","),s=Ea.rgbToHex(c[0],c[1],c[2]),r.push(s)),[o,r])}parseRawAnnots(t,e,n,r){var o,a,i,c,s,l;for(l=!0,!1===isNaN(parseInt(n[e],10))&&(l=!1),o=e;o<n.length;o++)a=n[o],[i,c]=this.parseAnnotFromTsvLine(a,r,l),null!==i&&t[i].annots.push(c);return s=["name","start","length","trackIndex"],n[e].length>=8&&s.push("color"),{keys:s,annots:t}}parseBed(t,e){var n,r,o,a,i=[],c=t.split(/\r\n|\n/);for(r=Object.keys(e.chromosomes[e.config.taxid]),n=0;n<r.length;n++)o=r[n],i.push({chr:o,annots:[]});return a=0,("chr"===c[0].slice(0,3)||isNaN(parseInt(c[0],10)))&&(a=1),this.parseRawAnnots(i,a,c,r)}}var Ma=["name","start","length","trackIndex","trackIndexOriginal","color"],qa={3:["00B","DDD","F00"],5:["00D","66D","DDD","F88","F00"],17:["00D","00D","00D","00D","00D","44D","44D","DDD","DDD","DDD","DDD","F88","F66","F22","F22","F00","F00","F00"]};function ka(t){var e,n,r;if(t.rawAnnots.metadata&&t.rawAnnots.metadata.trackLabels)e=t.rawAnnots.metadata.trackLabels;else if(t.config.heatmaps)for(e=[],n=t.config.heatmaps,r=0;r<n.length;r++)e.push(n[r].key);else e=t.rawAnnots.keys.slice(0).filter(t=>!Ma.includes(t));return t.displayedTrackIndexes&&(e=e.filter((function(e,n){return t.displayedTrackIndexes.includes(n+1)}))),e}function Ga(t){var e,n,r=t.rawAnnots;if(!r.metadata||r.metadata.heatmapThresholds||t.config.heatmapThresholds)return e=t.config.heatmapThresholds?t.config.heatmapThresholds:t.rawAnnots.metadata.heatmapThresholds,n=qa[e.length+1],(e=e.map((t,e)=>[t,"#"+n[e]])).push(["+","#"+n.slice(-1)[0]]),e}function La(t,e,n,r,o){return t===e&&"+"===o&&n>r||n===o||0!==t&&t!==e&&n<=o&&n>r||0===t&&n<=o}function Oa(t,e){var n,r,o,a,i,c,s,l;for(n=0;n<t.length;n++)r=t.length-1,a=(o=t[n])[0],i=parseFloat(a),!1===isNaN(i)&&(a=i),0!==n&&(s=parseFloat(t[n-1][0])),c=o[1],La(n,r,e,s,a)&&(l=c);return l}function Ta(t){!function(t,e){var n,r,o,a,i=e.config.annotLabelHeight;for(11,a=e.config.demarcateCollinearChromosomes?2:0,(o=To.select(e.config.container+" #_ideogramTrackLabelContainer")).html(""),r=e.config.annotationHeight+i+4,n=0;n<t.length;n++)o.style("position","absolute").append("div").attr("class","_ideogramTrackLabel").style("opacity",1).style("position","absolute").style("text-align","center").style("padding","1px").style("font","11px sans-serif").style("background","white").style("line-height","10px").style("z-index","5").style("left",11+a+"px").style("top",r*n+a+"px").style("width","max-content").style("transform-origin","bottom left").style("text-align","left").html(t[n])}(ka(t),t)}function Aa(t,e,n){var r,o,a,i,c,s=t.width,l=[],u=n.config.annotLabelHeight,p=n.config.numAnnotTracks;for(r=0;r<p;r++)a=n.config.annotationHeight+u+4,c=t.id+"-canvas-"+r,o=e,t.chrIndex>0&&(o+=n.config.chrMargin*t.chrIndex-1),i=To.select(n.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",c).attr("width",s+1).attr("height",a).style("position","absolute").style("left",o+"px").style("top",a*r+1+"px").nodes()[0].getContext("2d"),l.push([i,t]);return l}function Ra(t,e,n){var r,o,a,i,c=n.config.annotLabelHeight,s=n.config.annotationHeight,l=n.config.demarcateCollinearChromosomes,u=s+c+4;for(r=0;r<t.length;r++)if(a=e[(o=t[r]).trackIndex][0],i=e[o.trackIndex][1],a.fillStyle=o.color,l){if(o.startPx<1||o.startPx>i.width-1)continue;a.fillRect(o.startPx,1,.5,u)}else a.fillRect(o.startPx,c+1,.5,s);if(l)for(r=0;r<e.length;r++)a=e[r][0],i=e[r][1],a.fillStyle="#555",0===i.chrIndex&&a.fillRect(0,0,1,u),a.fillRect(i.width-1,0,1.1,u),a.fillRect(0,0,i.width+1,1),n.config.chrMargin&&a.fillRect(0,0,1.1,u)}function Fa(t,e,n){var r,o,a,i=n.config.annotationHeight,c=n._layout.margin.top;for(a=t.values,r=0;r<a.length;r++)e.fillStyle=a[r],o=(r-1)*i,e.fillRect(o,t.startPx+c,i,2)}function Ia(t,e){var n,r,o=e.config.container,a=e._layout.margin.top,i=e.config.chrHeight+a,c=e.config.annotationHeight*t[0].values.length;for(To.selectAll(o+" canvas").remove(),To.select(o+" #_ideogramInnerWrap").style("max-width",c+"px"),To.select(o+" #_ideogram").attr("width",c),n=function(t,e,n,r){var o,a;return a=t.id+"-canvas",o=2*r.config.chrWidth+r.config.annotationHeight-.5,To.select(r.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",a).attr("width",n).attr("height",e).style("position","absolute").style("left",o+"px").style("top","0px").nodes()[0].getContext("2d")}(e.chromosomesArray[0],i,c,e),r=0;r<t.length;r++)Fa(t[r],n,e);e.onDrawAnnotsCallback&&e.onDrawAnnotsCallback()}function Ha(t,e,n,r,o,a,i){var c,s,l,u,p,d,h,f=i.config.heatmapThresholds;for(c=0;c<n.annots.length;c++){for(u=n.annots[c],(l={}).values=[],s=0;s<3;s++)l[a[s]]=u[s];for(s=3;s<a.length;s++)h=Oa(f,u[s]),l.values.push(h);p=l.start+l.length,l.chr=n.chr,l.chrIndex=o,l.startPx=i.convertBpToPx(r,l.start),d=i.convertBpToPx(r,p),l.px=Math.round((l.startPx+d)/2),t.push(l)}return t.shift(),[t,e]}function Da(t){!1!==t.config.showTrackLabel&&(t.hideTrackLabelTimeout=window.setTimeout((function(){To.select(t.config.container+" #_ideogramTrackLabel").transition().duration(500).style("opacity",0)}),250))}function Ba(t,e){var n,r,o;clearTimeout(e.hideTrackLabelTimeout),n=(n=ka(e)).join("<br>"),To.select(e.config.container+" #_ideogramTrackLabel").interrupt().style("top","").style("left","").style("transform",null).style("transform","rotate(-90deg)").html(n),[r,o]=function(t,e,n){var r,o,a,i,c;return r=e.id.split("-").slice(0,-1).join("-")+"-0",o=To.select(n.config.container+" #"+r).nodes()[0].getBoundingClientRect(),a=To.select(n.config.container+" #_ideogramTrackLabel").nodes()[0].getBoundingClientRect(),i=To.select(n.config.container).nodes()[0].getBoundingClientRect(),c=Math.round(o.left+a.width)-o.width-1,[c-=i.left-7,-(t.split("<br>").length-2)*o.width+2]}(n,t,e),function(t,e,n){To.select(n.config.container+" #_ideogramTrackLabel").style("opacity",1).style("left",e+"px").style("top",t+"px").style("width","max-content").style("transform-origin","bottom left").style("text-align","left").on("mouseover",(function(){clearTimeout(n.hideTrackLabelTimeout)})).on("mouseout",(function(){Da(n)}))}(o,r,e)}function Va(t,e,n,r){var o,a,i,c,s,l=[],u=r.config.numAnnotTracks;for(o=0;o<u;o++)i=r.config.annotationHeight,s=t.id+"-canvas-"+o,a=e-i*(u-o)-7,c=To.select(r.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",s).attr("width",i).attr("height",n).style("position","absolute").style("left",a+"px").nodes()[0].getContext("2d"),l.push(c);return 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0===this.maxAnnotsPerBar&&(this.maxAnnotsPerBar={},r=!0),function(t,e,n){var r,o,a,i,c,s,l;if(e||"relative"===n.config.histogramScaling){for(r=0,o=0;o<t.length;o++){for(a=0,i=t[o].annots,c=t[o].chr,s=0;s<i.length;s++)(l=i[s].count)>a&&(a=l),l>r&&(r=l);n.maxAnnotsPerBar[c]=a}n.maxAnnotsPerBarAllChrs=r}}(n=function(t,e,n,r){var o,a,i,c,s,l,u,p,d,h,f=r.config.barWidth;for(o in t)for(a=t[o].annots,c=e[(i=n[t[o].chr]).chrIndex].annots,s=0;s<a.length;s++)for(u=(l=a[s]).px-r.bump,p=0;p<c.length;p++)if(h=(d=c[p].px)+f,p===c.length-1&&(h+=f),u>=d&&u<h){e[i.chrIndex].annots[p].count+=1,e[i.chrIndex].annots[p].annots.push(l);break}return e}(t,n=function(t,e){var n,r,o,a,i,c,s,l=e.config.barWidth,u=[];for(n in t){for(o=(r=t[n]).bands[r.bands.length-1],a=Math.round(o.px.stop/l),i={chr:n,annots:[]},c=0;c<a;c++)s=c*l-e.bump,i.annots.push({bp:e.convertPxToBp(r,s+e.bump),px:s,count:0,chrIndex:r.chrIndex,chrName:n,color:e.config.annotationsColor,annots:[]});u.push(i)}return u}(e,this),e,this),r,this),n=function(t,e){var n,r,o,a,i,c,s,l=e._layout._isRotated;for(n=0;n<t.length;n++)for(r=t[n].annots,o=t[n].chr,a=0;a<r.length;a++)i=r[a].count,c="relative"===e.config.histogramScaling?i/e.maxAnnotsPerBar[o]:i/e.maxAnnotsPerBarAllChrs,s=!1===l?c*e.config.chrMargin:c*e.config.chrHeightOriginal*3,isNaN(s)&&(s=0),t[n].annots[a].height=s;return t}(n,this),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time spent in getHistogramBars: "+(n-t)+" ms")}(o,this),this.bars=n,n}function Ja(t,e){var n,r='fill="'+t.color+'" style="stroke: #AAA;"',o=t.shape;if('d="m7,3 l -5 9 l 9 0 z"','d="m2,9a 4.5,4.5 0 1,0 9,0a 4.5,4.5 0 1,0 -9,0"','height="10" width="10" y="3"',"shape"in t&&["circle","triangle"].includes(o)){if("circle"===o)n='<path d="m2,9a 4.5,4.5 0 1,0 9,0a 4.5,4.5 0 1,0 -9,0" '+r+"></path>";else if("triangle"===o){var a="";"vertical"===e.config.orientation&&(a=' transform="rotate(90, 7, 7)"'),n='<path d="m7,3 l -5 9 l 9 0 z"'+a+" 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n,r;if(!/heatmap/.test(t)&&"histogram"!==t){for(r=0,n=0;n<e.length;n++)r+=e[n].annots.length;r>2e3&&console.warn('Rendering more than 2000 annotations in Ideogram?\nTry setting "annotationsLayout" to "heatmap" or "histogram" in your Ideogram configuration object for better layout and performance.')}}(t,e),"histogram"===t&&(e=n.getHistogramBars(e)),r=function(t,e){return To.selectAll(e.selector+" .chromosome").data(t).selectAll("path.annot").data((function(t){return t.annots})).enter()}(n.fillAnnots(e),n),"tracks"===t?function(t,e){var n,r=e.config.annotationHeight;n=function(t){var e;return{triangle:"m0,0 l -"+t+" "+2*t+" l "+2*t+" 0 z",circle:"m -"+(e=t)+", "+e+"a "+e+","+e+" 0 1,0 "+2*e+",0a "+e+","+e+" 0 1,0 -"+2*e+",0",rectangle:"m0,0 l 0 "+2*t+"l "+t+" 0l 0 -"+2*t+"z"}}(r),t.append("g").attr("id",(function(t){return t.id})).attr("class","annot").attr("transform",(function(t){var n=e.config.chrWidth+t.trackIndex*r*2;return"translate("+t.px+","+n+")"})).append("path").attr("d",(function(t){return function(t,e){return t.shape&&"triangle"!==t.shape?"circle"===t.shape?e.circle:"rectangle"===t.shape?e.rectangle:t.shape:e.triangle}(t,n)})).attr("fill",(function(t){return t.color})).on("mouseover",(function(t,n){e.showAnnotTooltip(n,this)})).on("mouseout",(function(){e.startHideAnnotTooltipTimeout()})).on("click",(function(t,n){e.onClickAnnot(n)}))}(r,n):"overlay"===t?function(t,e){t.append("polygon").attr("id",(function(t){return t.id})).attr("class","annot").attr("points",(function(t){var n,r,o=e.config.chrWidth;return t.stopPx-t.startPx>1?(n=t.startPx,r=t.stopPx):(n=t.px-.5,r=t.px+.5),n+","+o+" "+r+","+o+" "+r+",0 "+n+",0"})).attr("fill",(function(t){return t.color})).on("mouseover",(function(t,n){e.showAnnotTooltip(n,this)})).on("mouseout",(function(){e.startHideAnnotTooltipTimeout()}))}(r,n):"histogram"===t&&function(t,e){var n,r,o={},a=e.config.chrWidth;for(r in 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#_ideogramLegend svg {float: left;} #_ideogramLegend ul {position: relative; left: -14px; list-style: none; float: left; padding-left: 10px; margin: 0 0 1em 0; width: auto; border: none;} #_ideogramLegend li {float: none; margin: 0;}#_ideogramLegend ul span {position: relative; left: -15px;} "),c.append("div").attr("id","_ideogramLegend").html(i)}(this),/heatmap/.test(e)?this.drawHeatmaps(t):(ni(e,t,this),this.onDrawAnnotsCallback&&this.onDrawAnnotsCallback())}function oi(t,e,n){return t.append("g").attr("class","syntenicRegion").attr("id",e).on("click",(function(){var t=this,e=To.selectAll(n.selector+" .syntenicRegion").filter((function(){return this!==t}));e.classed("hidden",!e.classed("hidden"))})).on("mouseover",(function(){var t=this;To.selectAll(n.selector+" .syntenicRegion").filter((function(){return this!==t})).classed("ghost",!0)})).on("mouseout",(function(){To.selectAll(n.selector+" .syntenicRegion").classed("ghost",!1)}))}function ai(t,e,n,r,o,a){var i,c;i="color"in a?a.color:"#CFC",c="opacity"in a?a.opacity:1,t.append("polygon").attr("points",e+", "+r.startPx+" "+e+", "+r.stopPx+" "+n+", "+o.stopPx+" "+n+", "+o.startPx).style("fill",i).style("fill-opacity",c)}function ii(t,e,n,r,o,a){var i,c;i="color"in a?a.color:"#CFC",c="opacity"in a?a.opacity:1,t.append("polygon").attr("points",r.startPx-15+", "+e+" "+(r.stopPx-15)+", "+e+" "+(o.stopPx-15)+", "+n+" "+(o.startPx-15)+", "+n).style("fill",i).style("fill-opacity",c)}function ci(t,e,n=null){var r,o,a,i;if(r=t.r1,o=t.r2,"string"==typeof r.chr){const t=e.config.taxids;e.config.multiorganism?(r.chr=e.chromosomes[t[0]][r.chr],o.chr=e.chromosomes[t[1]][o.chr]):(r.chr=e.chromosomes[t[0]][r.chr],o.chr=e.chromosomes[t[0]][o.chr])}var c=document.querySelector("#"+r.chr.id+"-chromosome-set"),s=c.getCTM().e,l=c.getCTM().f,u=document.querySelector("#"+o.chr.id+"-chromosome-set"),p=u.getCTM().e,d=u.getCTM().f;return null===n?"vertical"===e.config.orientation?(a=l-12,i=d-12):(a=s,i=p):(a=n,i=n),r.startPx=e.convertBpToPx(r.chr,r.start)+a,r.stopPx=e.convertBpToPx(r.chr,r.stop)+a,o.startPx=e.convertBpToPx(o.chr,o.start)+i,o.stopPx=e.convertBpToPx(o.chr,o.stop)+i,[r,o]}function si(t,e,n,r,o){t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.startPx).attr("y2",o.startPx),t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.stopPx).attr("y2",o.stopPx)}function li(t,e){var n=(new Date).getTime();(function(t,e,n){var r,o,a,i,c,s,l,u;for(r=0;r<t.length;r++)o=t[r],[a,i]=ci(o,n),ai(c=oi(e,a.chr.id+"_"+a.start+"_"+a.stop+"___"+i.chr.id+"_"+i.start+"_"+i.stop,n),l=(s=n.config.chrWidth)+46,u=s+240,a,i,o),si(c,l,u,a,i)})(t,To.select(e.selector).insert("g",":first-child").attr("class","synteny"),e),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time in drawSyntenicRegions: "+(n-t)+" ms")}(n,e)}function ui(t,e,n,r,o){t.append("line").attr("class","syntenyBorder").attr("x1",r.startPx-15).attr("x2",o.startPx-15).attr("y1",e).attr("y2",n),t.append("line").attr("class","syntenyBorder").attr("x1",r.stopPx-15).attr("x2",o.stopPx-15).attr("y1",e).attr("y2",n)}function pi(t,e){var n=(new Date).getTime();(function(t,e,n){var r,o,a,i,c,s,l,u;for(r=0;r<t.length;r++)o=t[r],[a,i]=ci(o,n),ii(c=oi(e,a.chr.id+"_"+a.start+"_"+a.stop+"___"+i.chr.id+"_"+i.start+"_"+i.stop,n),l=(s=n.config.chrWidth)+31,u=s+191,a,i,o),ui(c,l,u,a,i)})(t,To.select(e.selector).insert("g",":first-child").attr("class","synteny"),e),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time in drawSyntenicRegions: "+(n-t)+" ms")}(n,e)}function di(t,e,n,r,o,a){var i,c;Math.abs(r.startPx-r.startPx)<2&&Math.abs(r.stopPx-r.stopPx)<2?(i=a.color,c=a.width):(i="",c=""),t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.startPx).attr("y2",o.startPx).style("stroke",i).style("stroke-width",c),t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.stopPx).attr("y2",o.stopPx).style("stroke",i).style("stroke-width",i)}function hi(t,e,n,r,o,a){var i=a.split("__").map(t=>"label_"+t);if("name"in r){t.append("text").attr("id",i[0]).attr("y",r.startPx+3).text(r.name);var c=document.querySelector("#"+i[0]).getBoundingClientRect().width;To.select("#"+i[0]).attr("x",e-15-c)}"name"in o&&t.append("text").attr("id",i[1]).text(o.name).attr("x",n+15).attr("y",o.startPx+3).text(o.name)}function fi(t){var e=(new Date).getTime(),n=this.config;if(n.multiorganism&&"collinear"===n.geometry)return"vertical"===n.orientation?li(t,this):pi(t,this);(function(t,e,n,r){var o,a,i,c,s,l,u,p,d;for(o=0;o<t.length;o++)a=t[o],[i,c]=ci(a,r,n),l=oi(e,s=i.chr.id+"_"+i.start+"_"+i.stop+"___"+c.chr.id+"_"+c.start+"_"+c.stop,r),u=r.config.chrWidth,ai(l,p=r._layout.getChromosomeSetYTranslate(0),d=r._layout.getChromosomeSetYTranslate(1)-u,i,c,a),di(l,p,d,i,c,a),hi(l,p,d,i,c,s)})(t,To.select(this.selector).insert("g",":first-child").attr("class","synteny"),this._layout.margin.left,this),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time in drawSyntenicRegions: "+(n-t)+" ms")}(e,this)}function mi(){this.config.numAnnotTracks=this.config.annotationsNumTracks,To.selectAll(this.selector+" .annot").remove(),this.drawAnnots(this.processAnnotData(this.rawAnnots))}function gi(t){var e,n,r,o=this.rawAnnots.annots;return this.config.numAnnotTracks=t.length,e=function(t,e){var n,r,o,a,i,c,s;for(r=[],a=0;a<t.length;a++){for(o=t[a],i=[],c=0;c<o.annots.length;c++)s=(n=o.annots[c].slice())[3]+1,e.includes(s)&&(n[3]=e.indexOf(s),i.push(n));r.push({chr:o.chr,annots:i})}return r}(o,t),r={keys:this.rawAnnots.keys,annots:e},"collinear"===this.config.geometry&&ta(this),n=this.processAnnotData(r),To.selectAll(this.selector+" .annot").remove(),this.displayedTrackIndexes=t,this.drawAnnots(n),n}function vi(t){var e,n;return(e=t.keys).length<4||"trackIndex"!==e[3]||"trackIndexOriginal"===e[4]||(n=function(t,e){var n,r,o,a,i,c,s,l=[];for(s=1,n=0;n<t.length;n++){for(o=t[n],i=[],r=0;r<o.annots.length;r++)(c=(a=o.annots[r].slice())[3])+1>s&&(s=c+1),a.splice(4,0,c),i.push(a);l.push({chr:o.chr,annots:i})}return e.numAvailTracks=s,l}(t.annots,this),e.splice(4,0,"trackIndexOriginal"),t={keys:e,annots:n},this.rawAnnots.metadata&&(t.metadata=this.rawAnnots.metadata)),t}var bi=[["F00"],["F00","88F"],["F00","CCC","88F"],["F00","FA0","0AF","88F"],["F00","FA0","CCC","0AF","88F"],["F00","FA0","875","578","0AF","88F"],["F00","FA0","875","CCC","578","0AF","88F"],["F00","FA0","7A0","875","0A7","578","0AF","88F"],["F00","FA0","7A0","875","CCC","0A7","578","0AF","88F"],["F00","FA0","7A0","875","552","255","0A7","578","0AF","88F"]];function yi(t,e,n,r,o,a,i){return i.config.annotationTracks?o=function(t,e,n,r,o){var a;return e.trackIndex=n[3],(a=o.config.annotationTracks[e.trackIndex]).color&&(e.color=a.color),a.shape&&(e.shape=a.shape),t[r].annots.push(e),t}(o,t,n,a,i):"trackIndex"===e[3]&&1!==i.numAvailTracks?[o,r]=function(t,e,n,r,o,a){var i=bi[a.numAvailTracks-1];return t.trackIndex=e[3],t.trackIndexOriginal=e[4],t.color="#"+i[t.trackIndexOriginal],t.trackIndex>a.config.numTracks-1?(t.trackIndex in n?n[t.trackIndex].push(t):n[t.trackIndex]=[t],[r,n]):(r[o].annots.push(t),[r,n])}(t,n,r,o,a,i):o=function(t,e,n,r){return e.trackIndex=0,e.color||(e.color=r.config.annotationsColor),e.shape||(e.shape="triangle"),t[n].annots.push(e),t}(o,t,a,i),[o,r]}function Si(t,e,n,r,o,a,i){var c,s,l,u;for(c=0;c<n.annots.length;c++){for(u=n.annots[c],l={},s=0;s<a.length;s++)l[a[s]]=u[s];l.stop=l.start+l.length,l.chr=n.chr,l.chrIndex=o,l.startPx=i.convertBpToPx(r,l.start),l.stopPx=i.convertBpToPx(r,l.stop),l.px=Math.round((l.startPx+l.stopPx)/2),[t,e]=yi(l,a,u,e,t,o,i)}return[t,e]}function Ci(t){console.warn('Chromosome "'+t.chr+'" undefined in ideogram; '+t.annots.length+" annotations not shown")}function xi(t){var e,n,r;return e=t.keys,t=t.annots,[n,r]=function(t,e,n){var r,o,a,i,c=[],s={};for(r=-1,o=0;o<t.length;o++)a=t[o],void 0!==(i=n.chromosomes[n.config.taxid][a.chr])?(r++,c.push({chr:a.chr,annots:[]}),"heatmap-2d"!==n.config.annotationsLayout?[c,s]=Si(c,s,a,i,r,e,n):[c,s]=Ha(c,s,a,i,r,e,n)):Ci(a);return[c,s]}(t,e,this),n=function(t,e){var n,r,o,a,i,c;for(n=t,t=[],c=e.chromosomesArray,r=0;r<c.length;r++)for(i=c[r].name,o=0;o<n.length;o++)(a=n[o]).chr===i&&t.push(a);return t}(n,this),function(t,e){var n,r=e.config.annotationsLayout,o=e.config.numAnnotTracks;!/heatmap/.test(r)&&o>10&&console.error("Ideogram only displays up to 10 tracks at a time. You specified "+o+" tracks. Perhaps consider a different way to visualize your data."),(n=Object.keys(t).length)&&console.warn("Ideogram configuration specified "+o+" tracks, but loaded annotations contain "+n+" extra tracks.")}(r,this),n}class _i{constructor(t,e){this.matrix=t,this.ideo=e}setRawAnnots(){var t,e,n;return t=this,e=this.ideo,n=this.matrix,new Promise((function(r){t.rawAnnots=t.fetchCoordinates(e).then((function(o){t.coordinates=o,r(t.parseExpressionMatrix(n,e))}))}))}fetchCoordinates(t){var e={};if("human"===t.config.organism){var n=t.config.dataDir+"../../annotations/Homo_sapiens,_Ensembl_80.tsv";return new Promise((function(r){t.fetch(n,"text").then((function(t){var n,o,a,i,c,s,l,u;for(n=t.split(/\r\n|\n/).slice(1),o=0;o<n.length;o++)[a,i,c,u,s]=n[o].split(/\s/g),a=parseInt(a),l=(i=parseInt(i))-a,e[c]=[s,a,l];r(e)}))}))}throw Error("Expression matrix parsing is only supported for human")}parseAnnotFromTsvLine(t,e){var n,r,o,a,i,c=t.split(/\s/g);return(a=c[0])in this.coordinates==!1?[null,null]:(i=c.slice(1).map(t=>parseFloat(t)),[r,o,length]=this.coordinates[a],-1===(n=e.indexOf(r))?[null,null]:[n,[a,o,length].concat(i)])}parseExpressionMatrix(t,e){var n,r,o,a,i,c,s=[],l=t.split(/\r\n|\n/);for(r=Object.keys(e.chromosomes[e.config.taxid]),n=0;n<r.length;n++)s.push({chr:r[n],annots:[]});for(n=1;n<l.length;n++)a=l[n],[i,c]=this.parseAnnotFromTsvLine(a,r),null!==i&&s[i].annots.push(c);return o=l[0].split(/\s/g),{keys:["name","start","length"].concat(o),annots:s}}}function wi(){const t=this,e={};t.annots.forEach(n=>{n.annots.forEach(n=>{const r=t.annotDescriptions.annots[n.name];e[n.name]=[n.name,r.ensemblId,n.chr,n.start,n.stop,n.length,r.type]})});const n=[["# Gene name","Ensembl ID","Chromosome","Start","Stop","Length","Type"]].concat(Object.values(e)),r=t.annotDescriptions.headers+"\n#\n"+n.map(t=>t.join("\t")).join("\n"),o="data:text/plain;charset=utf-8,"+encodeURIComponent(r);var a=new MouseEvent("click",{view:window,bubbles:!1,cancelable:!0}),i=document.createElement("a");i.setAttribute("download","ideogram.tsv"),i.setAttribute("href",o),i.setAttribute("target","_blank"),i.setAttribute("id","_ideo-undisplayed-dl-annots-link"),i.setAttribute("style","display: none;"),document.body.appendChild(i),i.dispatchEvent(a)}function zi(){var t=this.config;!function(t){var e,n=t.config;n.annotationHeight||("heatmap"===n.annotationsLayout?e=n.chrWidth-1:(e=Math.round(n.chrHeight/100))<3&&(e=3),t.config.annotationHeight=e)}(this),t.annotationsPath||t.localAnnotationsPath||this.annots||t.annotations?function(t,e){e.annotationTracks?t.config.numAnnotTracks=e.annotationTracks.length:e.annotationsNumTracks?t.config.numAnnotTracks=e.annotationsNumTracks:t.config.numAnnotTracks=1,t.config.annotTracksHeight=e.annotationHeight*e.numAnnotTracks,void 0===e.barWidth&&(t.config.barWidth=3)}(this,t):(this.config.annotTracksHeight=0,this.config.numAnnotTracks=0),void 0===t.annotationsColor&&(this.config.annotationsColor="#F00"),t.onClickAnnot&&(this.onClickAnnotCallback=t.onClickAnnot),function(t,e){!1!==e.showAnnotTooltip&&(t.config.showAnnotTooltip=!0),e.onWillShowAnnotTooltip&&(t.onWillShowAnnotTooltipCallback=e.onWillShowAnnotTooltip)}(this,t)}function Ei(){var t=this.config;this.rawAnnots.annots=this.rawAnnots.annots.sort((function(t,e){return t.chr.localeCompare(e.chr,"en",{numeric:!0})})),this.onLoadAnnotsCallback&&this.onLoadAnnotsCallback(),("heatmapThresholds"in t||"metadata"in this.rawAnnots&&"heatmapThresholds"in this.rawAnnots.metadata)&&("heatmap"===t.annotationsLayout?function(t){var e,n,r,o,a,i,c=t.config.heatmapThresholds;for(r=[],n=(a=t.rawAnnots).keys.slice(3),o=[],i=[],!a.metadata&&isNaN(c[0])||(c=Ga(t)),e=0;e<n.length;e++)r.push({key:n[e],thresholds:c}),o.push({id:n[e]}),i.push(e+1);t.config.annotationsNumTracks=n.length,t.config.annotationsDisplayedTracks=i,t.config.heatmaps=r,t.config.annotationTracks=o}(this):"heatmap-2d"===t.annotationsLayout&&(this.config.heatmapThresholds=Ga(this))),t.heatmaps&&this.deserializeAnnotsForHeatmap(this.rawAnnots)}function Mi(t){var e,n,r=this,o=r.config;n="heatmap-2d"===o.annotationsLayout,"http"===t.slice(0,4)||n?(e=n?"":function(t){var e,n;return"bed"!==(n=(e=t.split("?")[0].split("."))[e.length-1])&&"json"!==n?(n=n.toUpperCase(),void alert("Ideogram.js only supports BED and Ideogram JSON at the moment. Sorry, check back soon for "+n+" support!")):n}(t),r.fetch(t,"text").then((function(t){(r.rawAnnotsResponse=t,n)?new _i(t,r).setRawAnnots().then((function(t){r.rawAnnots=t,r.afterRawAnnots()})):(r.rawAnnots="bed"===e?new Ea(t,r).rawAnnots:JSON.parse(t),r.afterRawAnnots())}))):r.fetch(t).then((function(t){r.rawAnnotsResponse=t,r.rawAnnots=t,r.afterRawAnnots()}))}function qi(t){var e,n,r,o,a,i,c;for(e=[],n=[],r=this.chromosomesArray,o=0;o<r.length;o++)a=r[o].name,n.push(a),e.push({chr:a,annots:[]});for(o=0;o<t.length;o++)i=t[o],-1!==(c=n.indexOf(i.chr))&&(e[c]=i);return e}function ki(t,e="red"){const n=this,r=n.config.taxid,o=t.map(t=>{const o=n.chromosomes[r][t].id,a=`${n.selector} #${o}-chromosome-set`,i=document.querySelector(a),c=i.getBoundingClientRect();return`<rect class="ideo-highlight" ${`id="ideo-highlight-${o}"`} ${`style="\n stroke-width: 1px;\n stroke: ${e};\n fill: ${e};\n fill-opacity: 0.05;\n position: absolute;\n rx: 4;\n ry: 4;\n height: ${c.width+15}px;\n width: 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Promise((function(n){e.coordinateSystem="bp",e.getAssemblyAndChromosomesFromEutils(t,n)}));n=e.config.dataDir,r=Po(e.organisms[t].scientificName),o=[t],["9606","10090","10116"].includes(t)&&!e.config.showFullyBanded&&(r+="-no-bands");var a=n+r+".json";return new Promise((function(t,e){fetch(a).then((function(n){if(!1!==n.ok)return n.json().then((function(e){t(e.chrBands)}));e(Error("Fetch failed for "+a))}))})).then((function(n){var r,a,i,c,s=[""],l=[],u={};e.bandData[t]=n;for(var p=0;p<n.length;p++)r=(i=n[p].split(" "))[0],c=i.slice(-1)[0],r in u||(l.push({name:r,type:"nuclear",length:c}),u[r]=1);return l=l.sort(Ideogram.sortChromosomes),a={bp:0,iscn:0},l.forEach(t=>{t.length>a.bp&&(a.bp=t.length)}),e.maxLength[t]=a,s.push(l),s.push(o),s}),(function(){return new Promise((function(n){e.coordinateSystem="bp",e.getAssemblyAndChromosomesFromEutils(t,n)}))}))})(t,n).then((function(l){r=l[0],o=l[1],"chromosomes"in s==!1||null===s.chromosomes?(n.config.chromosomes={},n.config.chromosomes[t]=o):(s.multiorganism?t in s.chromosomes?a=s.chromosomes[t]:(i=Po(n.getScientificName(t)),n.config.chromosomes[t]=s.chromosomes[i].slice(),a=n.config.chromosomes[t]):a=s.chromosomes,c=o.filter(t=>a.includes(t.name)),n.config.chromosomes[t]=c),n.chromosomes[t]=n.config.chromosomes[t].slice(),n.organisms[t].assemblies={default:r},e()}))}function Ai(t,e){var n,r;for(n in e.organisms)if(r=e.organisms[n],n===Po(t)||Po(r.commonName)===Po(t)||Po(r.scientificName)===Po(t))return!0;return!1}function Ri(t){var e,n,r,o,a,i=t.config;return e=[],n={},function(t,e){var n,r,o,a=[],i={};for(o=0;o<t.length;o++)r=!1===Ai(n=t[o],e)?Li(n,e).then((function(t){var n,r,o=t[1];r=(n=t[0].replace("-"," "))[0].toUpperCase()+n.slice(1),i[o]={scientificName:r,commonName:"",assemblies:{default:""}},Object.assign(e.organisms,i)})):new Promise((function(t){var r=e.getTaxid(n);i[r]=e.organisms[r],t()})),a.push(r);return Promise.all(a).then((function(){return i}))}(i.multiorganism?i.organism:[i.organism],t).then((function(t){var c=t[o];for(o in t)c=t[o],e.push(o),i.multiorganism&&(void 0!==i.chromosomes?((a=Object.keys(i.chromosomes).map(t=>Po(t))).includes(Po(c.scientificName))?r=c.scientificName:a.includes(Po(c.commonName))&&(r=c.commonName),Po(r)in i.chromosomes?n[o]=i.chromosomes[Po(r)]:n[o]=i.chromosomes[r.toLowerCase()]):n=null);return[n,e]}))}function Fi(t,e){Ri(e).then((function([n,r]){var o,a,i,c,s,l=e.config,u=[];for(o=0;o<r.length;o++)a=r[o],c=e.organisms[a].assemblies,s=Object.values(c),""===c.default||e.assemblyIsAccession()&&!s.includes(l.assembly)?i=new Promise((function(t){Ti(a,t,e)})):(e.config.taxids=r,e.config.multiorganism&&(e.config.chromosomes=n),i=new Promise((function(t){t()}))),u.push(i);Promise.all(u).then((function(){return r=function(t){var e,n,r;if(e=t.config.organism,n=[],Array.isArray(e))for(r=0;r<e.length;r++)n.push(t.getTaxid(e[r]));else n.push(t.getTaxid(e));return n}(e),e.config.taxids=r,t(r)}))}))}function Ii(t){var e;if(e="taxid"in this.config,this.config.multiorganism=function(t,e){return"organism"in e.config&&e.config.organism instanceof Array||t&&e.config.taxid instanceof Array}(e,this),this.config.multiorganism&&(this.coordinateSystem="bp"),"organism"in this.config){const e=this.config.organism;"string"==typeof e&&(this.config.organism=Po(e.toLowerCase())),Fi(t,this)}else!function(t,e,n){var r;n.config.multiorganism?t&&(r=n.config.taxid):(t&&(r=[n.config.taxid]),n.config.taxids=r),e(r)}(e,t,this)}function Hi(t,e){var n,r;return[n,r]=function(t,e){var n=t.genome;return"mitochondrion"===n?function(t,e){var n,r;return e.config.showNonNuclearChromosomes?(n=t.genome,[-1===(r=t.subtype.split("|").indexOf("plasmid"))?"MT":t.subname.split("|")[r],n]):[null,null]}(t,e):"chloroplast"===n||"plastid"===n?function(t){return t.config.showNonNuclearChromosomes?["CP","chloroplast"]:[null,null]}(e):"apicoplast"===n?function(t){return t.config.showNonNuclearChromosomes?["AP","apicoplast"]:[null,null]}(e):function(t){var e,n;return"nuclear",e=t.subtype.split("|").indexOf("chromosome"),void 0!==(n=t.subname.split("|")[e])&&"chr"===n.substr(0,3)&&(n=n.substr(3)),[n,"nuclear"]}(t)}(t,e),{name:n,length:t.slen,type:r}}function Di(t,e){var n,r=this,o=function(t,e){var n;return n=e.assemblyIsAccession()?e.config.assembly+"%22[Assembly%20Accession]":t+"%22[taxid]AND%20(%22latest%20refseq%22[filter])%20",e.esearch+"&db=assembly&term=%22"+n+"AND%20(%22chromosome%20level%22[filter]%20OR%20%22complete%20genome%22[filter])"}(t,r);To.json(o).then((function(t){return function(t,e){var n,r;return n=t.esearchresult.idlist[0],r=e.esummary+"&db=assembly&id="+n,To.json(r)}(t,r)})).then((function(t){var e=t.result.uids[0];return n=t.result[e],function(t,e){var n;return n="&db=nuccore&dbfrom=assembly&linkname=assembly_nuccore&cmd=neighbor_history&from_uid="+t,To.json(e.elink+n).then((function(t){var r=t.linksets[0].webenv;return n="&db=nuccore&term=%231+AND+%28sequence_from_chromosome[Properties]+OR+sequence_from_plastid[Properties]+OR+sequence_from_mitochondrion[Properties]%29&WebEnv="+r+"&usehistory=y&retmax=1000",e.esearch+n}))}(e,r)})).then((function(t){return To.json(t)})).then((function(t){return function(t,e){var n,r;return n=t.esearchresult.idlist.join(","),r=e.esummary+"&db=nucleotide&id="+n,To.json(r)}(t,r)})).then((function(o){var a=function(t,e,n){var r,o,a,i,c={},s=[];for(r in t)"uids"!==r&&(a=(o=Hi(t[r],n)).name+"_"+o.length,null!==o.type&&a in c==!1&&s.push(o),c[a]=1);return s=s.sort(Ideogram.sortChromosomes),i={bp:0,iscn:0},s.forEach(t=>{t.length>i.bp&&(i.bp=t.length)}),i.bp>n.maxLength.bp&&(n.maxLength.bp=i.bp),n.maxLength[e]=i,n.coordinateSystem="bp",s}(o.result,t,r);return e([n,a])}),(function(t){console.warn(t)}))}function Bi(){var t=this.bandsToShow.join(",");0!==this.bandsToShow.length&&(To.selectAll(this.selector+" .bandLabel, 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e=a.getChromosomeBandLabelTranslate(t,i);return"horizontal"===o.config.orientation?r[n.id].push(e.x+13):r[n.id].push(e.y+6),e.translate})).append("text").attr("text-anchor",a.getChromosomeBandLabelAnchor(i)).text((function(t){return t.name})),r}function Wi(t,e,n,r){var o=this;t.selectAll("line.bandLabelStalk").data(e).enter().append("g").attr("class",(function(t,e){return"bandLabelStalk bsbsl-"+e})).attr("transform",(function(t){var e;return e=o.round(t.px.start+t.px.width/2),-10,r[n.id].push(e+13),"translate("+e+","+-10+")"})).append("line").attr("x1",0).attr("y1",o._layout.getChromosomeBandTickY1(n.chrIndex)).attr("x2",0).attr("y2",o._layout.getChromosomeBandTickY2(n.chrIndex))}function Qi(t){var e,n,r,o,a,i={};for(o=function(t){var e,n,r=[];for(e in t)for(n in t[e])r.push(t[e][n]);return r}(t),e=0;e<o.length;e++)r=o[e],n=To.select(this.selector+" 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i,c,s;i=a.convertBpToPx(t,e)+r,c=a.convertBpToPx(t,n)+r,s=a._layout.getChromosomeSetYTranslate(0)+(a.config.chrWidth-o)/2,To.select(a.selector).append("g").attr("class","brush").attr("transform","translate(0, "+s+")").call(a.brush).call(a.brush.move,[i,c])}(r,e,n,s,c,this)}function oc(){call(this.onCursorMoveCallback)}function ac(t){var e,n,r,o=this.config.chrWidth+6.5,a=this._layout.margin.left;if(void 0===t)return!1;e=function(t,e){var n,r;for(n=0;n<e.chromosomesArray.length;n++)if((r=e.chromosomesArray[n]).name===t)return r}(this.config.chromosome,this),[n,r]=function(t,e){var n,r,o=[1],a=[1],i=t.bands.slice(-1)[0];for(r=0;r<t.bands.length;r++)n=t.bands[r],o.push(n.bp.start),a.push(n.px.start+e);return o.push(i.bp.stop-1),a.push(i.px.stop+e),[o,a]}(e,a),function(t,e,n,r,o,a){var i;i=To.scaleLinear().domain(e).range(n),"rotatable"in a.config&&!1===a.config.rotatable||console.warn("Using the cursor with rotate is not supported.");var 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right">&blacktriangleright;</span></li>\n <li id="about-tool">About</li>\n </ul>\n </div>'),os(t),function(t){const e=document.querySelector(t.selector),n=document.querySelector("#gear"),r=document.querySelector("#tools");e.addEventListener("mouseover",()=>n.style.display=""),e.addEventListener("mouseout",()=>{"none"===r.style.display&&(n.style.display="none")}),n.addEventListener("mouseover",()=>n.style.display="")}(t)}class is{constructor(t){this._model=t,this._class="ModelAdapter"}static getInstance(t){return t.bands?new is(t):new cs(t)}getModel(){return this._model}getCssClass(){return""}}class cs extends is{constructor(t){super(t),this._class="ModelNoBandsAdapter"}getModel(){this._model.bands=[];const t="MT"===this._model.name,e=this._model.width;return(e>1||t)&&this._model.bands.push({name:"q",px:{start:0,stop:e,width:e},bp:{start:1,stop:this._model.bpLength},iscn:{start:1,stop:this._model.length}}),this._model}getCssClass(){return"noBands"}}class ss{constructor(t){this._config=t,this._ploidy=new ra(this._config)}getArmColor(t,e,n){return this._config.armColors?this._config.armColors[n]:this._config.ancestors?this._getPolyploidArmColor(t,e,n):null}getBorderColor(t,e,n){const r=this._config,o=r.chrBorderColor?r.chrBorderColor:"#000";return e<r.ploidy||this._ploidy.exists(t,e,n)?o:"#fff"}_getPolyploidArmColor(t,e,n){if(this._ploidy.exists(t,e,n)){var r=this._ploidy.getAncestor(t,e,n);return this._config.ancestors[r]}return"transparent"}}class ls{constructor(t){this._data=t,this.start=t.start,this.stop=t.stop,this.length=this.stop-this.start}getColor(t){return"ploidy"in this._data?"ploidy"in this._data&&this._data.ploidy[t]?this._getColor(t):"transparent":this._getColor(t)}_getColor(t){return Array.isArray(this._data.color)?this._data.color[t]:this._data.color}}class us{constructor(t,e,n){this._adapter=t,this._model=this._adapter.getModel(),this._config=e,this._ideo=n,this._color=new ss(this._config),this._bumpCoefficient=5}static getInstance(t,e,n){const r=t.getModel().centromerePosition;return"telocentric-p"===r?new ds(t,e,n):"telocentric-q"===r?new hs(t,e,n):new ps(t,e,n)}_addPArmShape(t,e){return e?t.concat(this._getPArmShape()):t}_addQArmShape(t,e){return e?t.concat(this._getQArmShape()):t}render(t,e,n){var r,o,a,i,c,s,l;return r=this,t=t.append("g").attr("class","bands").attr("clip-path","url(#"+this._model.id+"-chromosome-set-clippath)"),o=this._renderArm(t,e,n,"p"),a=this._renderArm(t,e,n,"q"),this._renderRangeSet(t,e,n),i=[],i=this._addPArmShape(i,o),i=this._addQArmShape(i,a),c="0",s="",l=this.isFullyBanded(),"ancestors"in this._ideo.config&&!("rangeSet"in this._ideo.config)?(s=r._color.getArmColor(e,n,0),l&&(c="0.5")):l?(c=null,s="transparent"):"ancestors"in this._ideo.config||(c="1"),t.append("g").attr("class","chromosome-border").selectAll("path").data(i).enter().append("path").attr("fill",s).style("fill-opacity",c).attr("stroke",(function(t,o){return r._color.getBorderColor(e,n,o)})).attr("stroke-width",(function(t){return"strokeWidth"in t?t.strokeWidth:1})).attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),i}_renderRangeSet(t,e,n){var r,o,a,i;"rangeSet"in this._config&&(o=this._config.rangeSet.filter((function(t){return t.chr-1===e})).map((function(t){return new ls(t)})),a=t.append("g").attr("class","range-set"),i=(r=this)._ideo,a.selectAll("rect.range").data(o).enter().append("rect").attr("class","range").attr("x",(function(t){return i.convertBpToPx(r._model,t.start)})).attr("y",0).attr("width",(function(t){return i.convertBpToPx(r._model,t.length)})).attr("height",this._config.chrWidth).style("fill",(function(t){return t.getColor(n)})))}_getShapeData(){var t,e,n,r;for(e=0;e<this._model.bands.length;e++)if("q"===this._model.bands[e].name[0]){t=this._model.bands[e];break}return n=this._model.bands.length-1,r=this._model.bands[n].px.stop,{x1:0,x2:t?t.px.start:r,x3:r,w:this._config.chrWidth,b:this._config.chrWidth/this._bumpCoefficient}}_getPArmShape(){var t=this._getShapeData(),e=t.x2-t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+t.b+",0 L"+e+",0 Q"+(t.x2+t.b)+","+t.w/2+","+e+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}:[{class:"",path:"M"+t.b+",0 L"+(e-2)+",0 L"+(e-2)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"},{class:"acen",path:"M"+e+",0 Q"+(t.x2+t.b)+","+t.w/2+","+e+","+t.w+" L"+e+","+t.w+" L"+(e-2)+","+t.w+" L"+(e-2)+",0"}]}_getQArmShape(){var t=this._getShapeData(),e=t.x3-t.b,n=t.x2+t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+n+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+n+","+t.w+" Q"+(t.x2-t.b)+","+t.w/2+","+n+",0"}:[{path:"M"+n+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+n+","+t.w+" L"+n+",0"},{class:"acen",path:"M"+n+",0Q"+(t.x2-t.b)+","+t.w/2+","+n+","+t.w+" L"+n+","+t.w+"L"+(n+2)+","+t.w+"L"+(n+2)+",0"}]}isFullyBanded(){return this._model.bands&&(2!==this._model.bands.length||"q"===this._model.bands[0].name[0])}_renderBands(t,e,n,r,o){var a,i,c;i="p"===o?0:1,c="","ancestors"in(a=this)._ideo.config&&!a.isFullyBanded()&&(c=a._color.getArmColor(e,n,i)),t.selectAll("path.band."+o).data(r).enter().append("path").attr("id",(function(t){return a._model.id+"-"+t.name.replace(".","-")})).attr("class",(function(t){return"band "+o+"-band "+t.stain})).attr("d",(function(t){var e;return"M "+a._ideo.round(t.px.start)+", 0l "+(e=a._ideo.round(t.px.width))+" 0 l 0 "+a._config.chrWidth+" l -"+e+" 0 z"})).style("fill",c)}_renderArm(t,e,n,r){var o=this._model.bands.filter((function(t){return t.name[0]===r}));return this._renderBands(t,e,n,o,r),Boolean(o.length)}}class ps extends us{constructor(t,e,n){super(t,e,n),this._class="MetacentricChromosome"}}class ds extends us{constructor(t,e,n){super(t,e,n),this._class="TelocentricPChromosome",this._pArmOffset=3}_addPArmShape(t){return t.concat(this._getPArmShape())}_getPArmShape(){var t=this._getShapeData();return t.o=this._pArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2-t.o+5)+",0L"+(t.x2-t.o+3)+",0 L"+(t.x2-t.o+3)+","+t.w+" L"+(t.x2-t.o+5)+","+t.w,strokeWidth:.5}]}_getQArmShape(){var t=this._getShapeData(),e=t.x3-t.b,n=this._pArmOffset+3;return{class:"",path:"M"+(t.x2+n)+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+(t.x2+n)+","+t.w}}}class hs extends us{constructor(t,e,n){super(t,e,n),this._class="TelocentricQChromosome",this._qArmOffset=3}_getPArmShape(){var t=this._getShapeData(),e=t.x3-t.b,n=this._qArmOffset;return{class:"",path:"M"+(t.x2+n)+",0 L"+(e+n)+",0 L"+(e+n)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}}_addQArmShape(t){return t.concat(this._getQArmShape())}_getQArmShape(){var t=this._getShapeData();return t.o=this._qArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1 L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2+t.o+5)+",0 L"+(t.x2+t.o+3)+",0 L"+(t.x2+t.o+3)+","+t.w+" L"+(t.x2+t.o+5)+","+t.w,strokeWidth:.5}]}}function fs(t,e,n,r){var o,a,i,c,s;c=To.select(this.selector+" defs"),s=is.getInstance(t),o=n*this.config.chrMargin,a=r.append("g").attr("id",t.id).attr("class","chromosome "+s.getCssClass()).attr("transform","translate(0, "+o+")"),i=us.getInstance(s,this.config,this).render(a,e,n),To.select("#"+t.id+"-chromosome-set-clippath").remove(),c.append("clipPath").attr("id",t.id+"-chromosome-set-clippath").selectAll("path").data(i).enter().append("path").attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),t.width<1&&To.select("#"+t.id+" .bands").style("opacity",0)}function ms(t){var e,n,r,o,a,i;if(e=t.chrIndex,o=this._layout.getChromosomeSetTranslate(e),i=this.selector+" #"+t.id+"-chromosome-set",To.selectAll(i+" g").remove(),0===(n=To.select(i)).nodes().length&&(n=To.select(this.selector).append("g").attr("class","chromosome-set").attr("transform",o).attr("id",t.id+"-chromosome-set")),"sex"in this.config&&2===this.config.ploidy&&this.sexChromosomes.index===e)this.drawSexChromosomes(n,e);else for(r=1,this.config.ploidy>1&&(r=this._ploidy.getChromosomesNumber(e)),a=0;a<r;a++)this.appendHomolog(t,e,a,n)}function gs(t){var e,n;this.unhighlight(),this.config.taxid&&(e=t.id.split("-")[0].replace("chr",""),n=this.chromosomes[this.config.taxid][e].chrIndex,this._layout.rotate(n,n,t))}function vs(){var t,e,n,r,o,a,i;t=this.config,o=To.select(t.container+" svg#_ideogram"),n=To.select(t.container+" #_ideogramInnerWrap"),r=To.select(t.container+" #_ideogramMiddleWrap"),i=1===(a=t.ploidy)?a:1.12*a;let c=0;"annotationsLayout"in t&&(c=t.annotationHeight*t.numAnnotTracks),"vertical"===t.orientation&&"comparative"!==t.perspective&&"collinear"!==t.geometry&&(e=this.numChromosomes*(t.chrWidth+t.chrMargin+c),"heatmap-2d"!==t.annotationsLayout&&(e=Math.ceil(e*i/t.rows),"SmallLayout"===this._layout._class&&(e+=100),e+=35,r.style("height",this._layout.getHeight()+"px"),n.style("max-width",e+"px").style("overflow-x","scroll").style("position","absolute"),o.style("min-width",e-5+"px"),this.config.showTools&&as(this)))}function bs(t){var e=t._layout;To.selectAll(t.selector+" .chromosome-set").insert("text",":first-child").data(t.chromosomesArray).attr("class",e.getChromosomeLabelClass()).attr("transform",e.getChromosomeSetLabelTranslate()).attr("x",e.getChromosomeSetLabelXPosition()).attr("y",(function(t,n){return e.getChromosomeSetLabelYPosition(n)})).attr("text-anchor",e.getChromosomeSetLabelAnchor()).each((function(e,n){!function(t,e,n,r){var o=function(t,e,n){var r;return r=-1===t.name.indexOf(" 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function ws(t,e){const n=`&format=condensed&type=paralogues&target_taxon=${e.config.taxid}`,r=`/homology/id/${t.id}?${n}`,o=(await Ideogram.fetchEnsembl(r)).data[0].homologies;return await async function(t,e){const n=[],r=`?q=${t.map(t=>`ensemblgene:${t.id}`).join(" OR ")}&species=${e.config.taxid}&fields=symbol,genomic_pos,name`;return(await Cs(r)).hits.forEach(t=>{if("genomic_pos"in t==!1)return;if("name"in t==!1)return;const r=zs(t,e,"pink");n.push(r);const o=t.name,{name:a,ensemblId:i}=xs(t),c={description:o,ensemblId:i,name:a,type:"paralogous gene"};e.annotDescriptions.annots[r.name]=c}),n}(o,e)}function zs(t,e,n="red"){let r=null;return r=Array.isArray(t.genomic_pos)?t.genomic_pos.filter(t=>t.chr in e.chromosomes[e.config.taxid])[0]:t.genomic_pos,{name:t.symbol,chr:r.chr,start:r.start,stop:r.end,id:r.ensemblgene,color:n}}function Es(t,e,n){return new Promise(async r=>{const o=await async function(t,e){const n={},r={},o=e.config.organism.replace(/-/g," 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i=document.querySelector("#_ideogramInnerWrap");if(i.style.position="relative",i.style.marginLeft="auto",i.style.marginRight="auto",i.style.overflowY="hidden",document.querySelector("#_ideogramMiddleWrap").style.overflowY="hidden",void 0===e.didAdjustIdeogramLegend){var c=document.querySelector("#_ideogram");const t=140;i.style.maxWidth=parseInt(i.style.maxWidth)+t+"px",c.style.maxWidth=parseInt(c.style.minWidth)+"px",c.style.position="relative",c.style.left=t+"px",e.didAdjustIdeogramLegend=!0}const s=`?q=symbol:${t}&species=${e.config.taxid}&fields=symbol,genomic_pos,name`,l=(await Cs(s)).hits[0],u=l.name,p=l.genomic_pos.ensemblgene;e.annotDescriptions.annots[l.symbol]={description:u,ensemblId:p,name:u,type:"searched gene"},e.relatedAnnots=[];const d=zs(l,e);e.relatedAnnots.push(d),await Promise.all([Es(d,i,e),Ms(d,i,e)]),e.timeRelatedGenes=Math.round(performance.now()-n),function(t){const e=t.annotDescriptions.annots,n=Object.keys(e).length,r=Object.values(e),o=r.filter(t=>"paralogous gene"===t.type).length,a=r.filter(t=>"interacting gene"===t.type).length,i=Object.entries(e).filter(t=>"searched gene"===t[1].type)[0][0],c=t.timeRelatedGenes;t.relatedGenesAnalytics={searchedGene:i,numRelatedGenes:n,numParalogs:o,numInteractingGenes:a,time:c}}(e),e.onPlotRelatedGenesCallback&&e.onPlotRelatedGenesCallback()}function Gs(t){const e=this.annotDescriptions.annots[t.name].description.split(" [")[0];return t.displayName=`<span id="ideo-related-gene" style="color: #0366d6; cursor: pointer;">${t.name}</span>\n <br/>\n ${e}\n <br/>`,function(t){const e=document.querySelector("._ideogramTooltip");t.addedTooltipClickHandler||(e.addEventListener("click",()=>{const e=function(t,e){var n;return e.annots.forEach(e=>{e.annots.forEach(e=>{t===e.name&&(n=e)})}),n}(document.querySelector("#ideo-related-gene").textContent,t);t.onClickAnnot(e)}),t.addedTooltipClickHandler=!0)}(this),t}const Ls=[{name:'\n <div style="position: relative; left: -15px; padding-bottom: 10px;">\n <div style="font-size: 14px; font-weight: bold; font-color: #333">Related genes</div>\n <i>Click gene to search</i>\n </div>\n ',nameHeight:30,rows:[{name:"Interacting gene",color:"purple",shape:"triangle"},{name:"Paralogous gene",color:"pink",shape:"triangle"},{name:"Searched gene",color:"red",shape:"triangle"}]}];class 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l(this,e),f(this,m(e).apply(this,arguments))}return v(e,t),p(e,[{key:"render",value:function(){var t=this.props,e=t.isEnabled,n=o(t,["isEnabled"]);return e?y.a.createElement(ge,n):this.props.children}}]),e}(b.Component);c(ve,"defaultProps",{isEnabled:!0});var be=function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n=e.isSearchable,r=e.isMulti,o=e.label,a=e.isDisabled;switch(t){case"menu":return"Use Up and Down to choose options".concat(a?"":", press Enter to select the currently focused option",", press Escape to exit the menu, press Tab to select the option and exit the menu.");case"input":return"".concat(o||"Select"," is focused ").concat(n?",type to refine list":"",", press Down to open the menu, ").concat(r?" press left to focus selected values":"");case"value":return"Use left and right to toggle between focused values, press Backspace to remove the currently focused value"}},ye=function(t,e){var n=e.value,r=e.isDisabled;if(n)switch(t){case"deselect-option":case"pop-value":case"remove-value":return"option ".concat(n,", deselected.");case"select-option":return"option ".concat(n,r?" is disabled. Select another option.":", selected.")}},Se=function(t){return!!t.isDisabled},Ce={clearIndicator:Dt,container:function(t){var e=t.isDisabled;return{label:"container",direction:t.isRtl?"rtl":null,pointerEvents:e?"none":null,position:"relative"}},control:function(t){var e=t.isDisabled,n=t.isFocused,r=t.theme,o=r.colors,a=r.borderRadius,i=r.spacing;return{label:"control",alignItems:"center",backgroundColor:e?o.neutral5:o.neutral0,borderColor:e?o.neutral10:n?o.primary:o.neutral20,borderRadius:a,borderStyle:"solid",borderWidth:1,boxShadow:n?"0 0 0 1px ".concat(o.primary):null,cursor:"default",display:"flex",flexWrap:"wrap",justifyContent:"space-between",minHeight:i.controlHeight,outline:"0 !important",position:"relative",transition:"all 100ms","&:hover":{borderColor:n?o.primary:o.neutral30}}},dropdownIndicator:Ht,group:function(t){var e=t.theme.spacing;return{paddingBottom:2*e.baseUnit,paddingTop:2*e.baseUnit}},groupHeading:function(t){var e=t.theme.spacing;return{label:"group",color:"#999",cursor:"default",display:"block",fontSize:"75%",fontWeight:"500",marginBottom:"0.25em",paddingLeft:3*e.baseUnit,paddingRight:3*e.baseUnit,textTransform:"uppercase"}},indicatorsContainer:function(){return{alignItems:"center",alignSelf:"stretch",display:"flex",flexShrink:0}},indicatorSeparator:function(t){var e=t.isDisabled,n=t.theme,r=n.spacing.baseUnit,o=n.colors;return{label:"indicatorSeparator",alignSelf:"stretch",backgroundColor:e?o.neutral10:o.neutral20,marginBottom:2*r,marginTop:2*r,width:1}},input:function(t){var e=t.isDisabled,n=t.theme,r=n.spacing,o=n.colors;return{margin:r.baseUnit/2,paddingBottom:r.baseUnit/2,paddingTop:r.baseUnit/2,visibility:e?"hidden":"visible",color:o.neutral80}},loadingIndicator:function(t){var e=t.isFocused,n=t.size,r=t.theme,o=r.colors,a=r.spacing.baseUnit;return{label:"loadingIndicator",color:e?o.neutral60:o.neutral20,display:"flex",padding:2*a,transition:"color 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e=t.theme,n=e.spacing,r=e.borderRadius;return{label:"multiValue",backgroundColor:e.colors.neutral10,borderRadius:r/2,display:"flex",margin:n.baseUnit/2,minWidth:0}},multiValueLabel:function(t){var e=t.theme,n=e.borderRadius,r=e.colors,o=t.cropWithEllipsis;return{borderRadius:n/2,color:r.neutral80,fontSize:"85%",overflow:"hidden",padding:3,paddingLeft:6,textOverflow:o?"ellipsis":null,whiteSpace:"nowrap"}},multiValueRemove:function(t){var e=t.theme,n=e.spacing,r=e.borderRadius,o=e.colors;return{alignItems:"center",borderRadius:r/2,backgroundColor:t.isFocused&&o.dangerLight,display:"flex",paddingLeft:n.baseUnit,paddingRight:n.baseUnit,":hover":{backgroundColor:o.dangerLight,color:o.danger}}},noOptionsMessage:xt,option:function(t){var e=t.isDisabled,n=t.isFocused,r=t.isSelected,o=t.theme,a=o.spacing,i=o.colors;return{label:"option",backgroundColor:r?i.primary:n?i.primary25:"transparent",color:e?i.neutral20:r?i.neutral0:"inherit",cursor:"default",display:"block",fontSize:"inherit",padding:"".concat(2*a.baseUnit,"px ").concat(3*a.baseUnit,"px"),width:"100%",userSelect:"none",WebkitTapHighlightColor:"rgba(0, 0, 0, 0)",":active":{backgroundColor:!e&&(r?i.primary:i.primary50)}}},placeholder:function(t){var e=t.theme,n=e.spacing;return{label:"placeholder",color:e.colors.neutral50,marginLeft:n.baseUnit/2,marginRight:n.baseUnit/2,position:"absolute",top:"50%",transform:"translateY(-50%)"}},singleValue:function(t){var e=t.isDisabled,n=t.theme,r=n.spacing,o=n.colors;return{label:"singleValue",color:e?o.neutral40:o.neutral80,marginLeft:r.baseUnit/2,marginRight:r.baseUnit/2,maxWidth:"calc(100% - ".concat(2*r.baseUnit,"px)"),overflow:"hidden",position:"absolute",textOverflow:"ellipsis",whiteSpace:"nowrap",top:"50%",transform:"translateY(-50%)"}},valueContainer:function(t){var e=t.theme.spacing;return{alignItems:"center",display:"flex",flex:1,flexWrap:"wrap",padding:"".concat(e.baseUnit/2,"px ").concat(2*e.baseUnit,"px"),WebkitOverflowScrolling:"touch",position:"relative",overflow:"hidden"}}};function xe(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n=s({},t);return Object.keys(e).forEach((function(r){t[r]?n[r]=function(n,o){return e[r](t[r](n,o),o)}:n[r]=e[r]})),n}var _e={borderRadius:4,colors:{primary:"#2684FF",primary75:"#4C9AFF",primary50:"#B2D4FF",primary25:"#DEEBFF",danger:"#DE350B",dangerLight:"#FFBDAD",neutral0:"hsl(0, 0%, 100%)",neutral5:"hsl(0, 0%, 95%)",neutral10:"hsl(0, 0%, 90%)",neutral20:"hsl(0, 0%, 80%)",neutral30:"hsl(0, 0%, 70%)",neutral40:"hsl(0, 0%, 60%)",neutral50:"hsl(0, 0%, 50%)",neutral60:"hsl(0, 0%, 40%)",neutral70:"hsl(0, 0%, 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e=n.props,r=e.blurInputOnSelect,o=e.isMulti,a=n.state.selectValue;if(o)if(n.isOptionSelected(t,a)){var c=n.getOptionValue(t);n.setValue(a.filter((function(t){return n.getOptionValue(t)!==c})),"deselect-option",t),n.announceAriaLiveSelection({event:"deselect-option",context:{value:n.getOptionLabel(t)}})}else n.isOptionDisabled(t,a)?n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t),isDisabled:!0}}):(n.setValue([].concat(i(a),[t]),"select-option",t),n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t)}}));else n.isOptionDisabled(t,a)?n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t),isDisabled:!0}}):(n.setValue(t,"select-option"),n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t)}}));r&&n.blurInput()})),c(h(h(n)),"removeValue",(function(t){var e=n.state.selectValue,r=n.getOptionValue(t),o=e.filter((function(t){return 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e=n.props,r=e.isMulti,o=e.menuIsOpen;n.focusInput(),o?(n.inputIsHiddenAfterUpdate=!r,n.onMenuClose()):n.openMenu("first"),t.preventDefault(),t.stopPropagation()}})),c(h(h(n)),"onClearIndicatorMouseDown",(function(t){t&&"mousedown"===t.type&&0!==t.button||(n.clearValue(),t.stopPropagation(),n.openAfterFocus=!1,"touchend"===t.type?n.focusInput():setTimeout((function(){return n.focusInput()})))})),c(h(h(n)),"onScroll",(function(t){"boolean"==typeof n.props.closeMenuOnScroll?t.target instanceof HTMLElement&&ut(t.target)&&n.props.onMenuClose():"function"==typeof n.props.closeMenuOnScroll&&n.props.closeMenuOnScroll(t)&&n.props.onMenuClose()})),c(h(h(n)),"onCompositionStart",(function(){n.isComposing=!0})),c(h(h(n)),"onCompositionEnd",(function(){n.isComposing=!1})),c(h(h(n)),"onTouchStart",(function(t){var e=t.touches.item(0);e&&(n.initialTouchX=e.clientX,n.initialTouchY=e.clientY,n.userIsDragging=!1)})),c(h(h(n)),"onTouchMove",(function(t){var e=t.touches.item(0);if(e){var 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e=n.props,r=e.isSearchable,o=e.isMulti;n.props.onFocus&&n.props.onFocus(t),n.inputIsHiddenAfterUpdate=!1,n.announceAriaLiveContext({event:"input",context:{isSearchable:r,isMulti:o}}),n.setState({isFocused:!0}),(n.openAfterFocus||n.props.openMenuOnFocus)&&n.openMenu("first"),n.openAfterFocus=!1})),c(h(h(n)),"onInputBlur",(function(t){n.menuListRef&&n.menuListRef.contains(document.activeElement)?n.inputRef.focus():(n.props.onBlur&&n.props.onBlur(t),n.onInputChange("",{action:"input-blur"}),n.onMenuClose(),n.setState({focusedValue:null,isFocused:!1}))})),c(h(h(n)),"onOptionHover",(function(t){n.blockOptionHover||n.state.focusedOption===t||n.setState({focusedOption:t})})),c(h(h(n)),"shouldHideSelectedOptions",(function(){var t=n.props,e=t.hideSelectedOptions,r=t.isMulti;return void 0===e?r:e})),c(h(h(n)),"onKeyDown",(function(t){var e=n.props,r=e.isMulti,o=e.backspaceRemovesValue,a=e.escapeClearsValue,i=e.inputValue,c=e.isClearable,s=e.isDisabled,l=e.menuIsOpen,u=e.onKeyDown,p=e.tabSelectsValue,d=e.openMenuOnFocus,h=n.state,f=h.focusedOption,m=h.focusedValue,g=h.selectValue;if(!(s||"function"==typeof u&&(u(t),t.defaultPrevented))){switch(n.blockOptionHover=!0,t.key){case"ArrowLeft":if(!r||i)return;n.focusValue("previous");break;case"ArrowRight":if(!r||i)return;n.focusValue("next");break;case"Delete":case"Backspace":if(i)return;if(m)n.removeValue(m);else{if(!o)return;r?n.popValue():c&&n.clearValue()}break;case"Tab":if(n.isComposing)return;if(t.shiftKey||!l||!p||!f||d&&n.isOptionSelected(f,g))return;n.selectOption(f);break;case"Enter":if(229===t.keyCode)break;if(l){if(!f)return;if(n.isComposing)return;n.selectOption(f);break}return;case"Escape":l?(n.inputIsHiddenAfterUpdate=!1,n.onInputChange("",{action:"menu-close"}),n.onMenuClose()):c&&a&&n.clearValue();break;case" ":if(i)return;if(!l){n.openMenu("first");break}if(!f)return;n.selectOption(f);break;case"ArrowUp":l?n.focusOption("up"):n.openMenu("last");break;case"ArrowDown":l?n.focusOption("down"):n.openMenu("first");break;case"PageUp":if(!l)return;n.focusOption("pageup");break;case"PageDown":if(!l)return;n.focusOption("pagedown");break;case"Home":if(!l)return;n.focusOption("first");break;case"End":if(!l)return;n.focusOption("last");break;default:return}t.preventDefault()}}));var r=t.value;n.cacheComponents=C(n.cacheComponents,Gt).bind(h(h(n))),n.cacheComponents(t.components),n.instancePrefix="react-select-"+(n.props.instanceId||++ze);var o=lt(r),a=t.menuIsOpen?n.buildMenuOptions(t,o):{render:[],focusable:[]};return n.state.menuOptions=a,n.state.selectValue=o,n}return v(e,t),p(e,[{key:"componentDidMount",value:function(){this.startListeningComposition(),this.startListeningToTouch(),this.props.closeMenuOnScroll&&document&&document.addEventListener&&document.addEventListener("scroll",this.onScroll,!0),this.props.autoFocus&&this.focusInput()}},{key:"UNSAFE_componentWillReceiveProps",value:function(t){var e=this.props,n=e.options,r=e.value,o=e.menuIsOpen,a=e.inputValue;if(this.cacheComponents(t.components),t.value!==r||t.options!==n||t.menuIsOpen!==o||t.inputValue!==a){var i=lt(t.value),c=t.menuIsOpen?this.buildMenuOptions(t,i):{render:[],focusable:[]},s=this.getNextFocusedValue(i),l=this.getNextFocusedOption(c.focusable);this.setState({menuOptions:c,selectValue:i,focusedOption:l,focusedValue:s})}null!=this.inputIsHiddenAfterUpdate&&(this.setState({inputIsHidden:this.inputIsHiddenAfterUpdate}),delete this.inputIsHiddenAfterUpdate)}},{key:"componentDidUpdate",value:function(t){var e,n,r,o,a,i=this.props,c=i.isDisabled,s=i.menuIsOpen,l=this.state.isFocused;(l&&!c&&t.isDisabled||l&&s&&!t.menuIsOpen)&&this.focusInput(),this.menuListRef&&this.focusedOptionRef&&this.scrollToFocusedOptionOnUpdate&&(e=this.menuListRef,n=this.focusedOptionRef,r=e.getBoundingClientRect(),o=n.getBoundingClientRect(),a=n.offsetHeight/3,o.bottom+a>r.bottom?dt(e,Math.min(n.offsetTop+n.clientHeight-e.offsetHeight+a,e.scrollHeight)):o.top-a<r.top&&dt(e,Math.max(n.offsetTop-a,0))),this.scrollToFocusedOptionOnUpdate=!1}},{key:"componentWillUnmount",value:function(){this.stopListeningComposition(),this.stopListeningToTouch(),document.removeEventListener("scroll",this.onScroll,!0)}},{key:"onMenuOpen",value:function(){this.props.onMenuOpen()}},{key:"onMenuClose",value:function(){var t=this.props,e=t.isSearchable,n=t.isMulti;this.announceAriaLiveContext({event:"input",context:{isSearchable:e,isMulti:n}}),this.onInputChange("",{action:"menu-close"}),this.props.onMenuClose()}},{key:"onInputChange",value:function(t,e){this.props.onInputChange(t,e)}},{key:"focusInput",value:function(){this.inputRef&&this.inputRef.focus()}},{key:"blurInput",value:function(){this.inputRef&&this.inputRef.blur()}},{key:"openMenu",value:function(t){var e=this.state,n=e.menuOptions,r=e.selectValue,o=e.isFocused,a=this.props.isMulti,i="first"===t?0:n.focusable.length-1;if(!a){var c=n.focusable.indexOf(r[0]);c>-1&&(i=c)}this.scrollToFocusedOptionOnUpdate=!(o&&this.menuListRef),this.inputIsHiddenAfterUpdate=!1,this.onMenuOpen(),this.setState({focusedValue:null,focusedOption:n.focusable[i]}),this.announceAriaLiveContext({event:"menu"})}},{key:"focusValue",value:function(t){var e=this.props,n=e.isMulti,r=e.isSearchable,o=this.state,a=o.selectValue,i=o.focusedValue;if(n){this.setState({focusedOption:null});var c=a.indexOf(i);i||(c=-1,this.announceAriaLiveContext({event:"value"}));var s=a.length-1,l=-1;if(a.length){switch(t){case"previous":l=0===c?0:-1===c?s:c-1;break;case"next":c>-1&&c<s&&(l=c+1)}-1===l&&this.announceAriaLiveContext({event:"input",context:{isSearchable:r,isMulti:n}}),this.setState({inputIsHidden:-1!==l,focusedValue:a[l]})}}}},{key:"focusOption",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:"first",e=this.props.pageSize,n=this.state,r=n.focusedOption,o=n.menuOptions,a=o.focusable;if(a.length){var 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e=this.options.fetchPolicy;this.options=Object(r.a)(Object(r.a)({},this.options),t),t.pollInterval?this.startPolling(t.pollInterval):0===t.pollInterval&&this.stopPolling();var n=t.fetchPolicy;return this.setVariables(this.options.variables,e!==n&&("cache-only"===e||"standby"===e||"network-only"===n),t.fetchResults)},e.prototype.setVariables=function(t,e,n){return void 0===e&&(e=!1),void 0===n&&(n=!0),this.isTornDown=!1,t=t||this.variables,!e&&Object(a.a)(t,this.variables)?this.observers.size&&n?this.result():Promise.resolve():(this.variables=this.options.variables=t,this.observers.size?this.queryManager.fetchQuery(this.queryId,this.options):Promise.resolve())},e.prototype.updateQuery=function(t){var e=this.queryManager,n=e.getQueryWithPreviousResult(this.queryId),r=n.previousResult,a=n.variables,i=n.document,c=Object(o.I)((function(){return 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t=this,e=this.queryManager,n=this.queryId;this.shouldSubscribe&&e.addObservableQuery(n,this),this.options.pollInterval&&(R(this),e.startPollingQuery(this.options,n));var o=function(e){t.updateLastResult(Object(r.a)(Object(r.a)({},t.lastResult),{errors:e.graphQLErrors,networkStatus:_.error,loading:!1})),A(t.observers,"error",t.lastError=e)};e.observeQuery(n,this.options,{next:function(n){if(t.lastError||t.isDifferentFromLastResult(n)){var r=t.updateLastResult(n),o=t.options,i=o.query,c=o.variables,s=o.fetchPolicy;e.transform(i).hasClientExports?e.getLocalState().addExportedVariables(i,c).then((function(o){var c=t.variables;t.variables=t.options.variables=o,!n.loading&&r&&"cache-only"!==s&&e.transform(i).serverQuery&&!Object(a.a)(c,o)?t.refetch():A(t.observers,"next",n)})):A(t.observers,"next",n)}},error:o}).catch(o)},e.prototype.tearDownQuery=function(){var t=this.queryManager;this.isTornDown=!0,t.stopPollingQuery(this.queryId),this.subscriptions.forEach((function(t){return 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this.store[t]},t.prototype.initQuery=function(t){var e=this.store[t.queryId];Object(s.b)(!e||e.document===t.document||Object(a.a)(e.document,t.document),19);var n,r=!1,o=null;t.storePreviousVariables&&e&&e.networkStatus!==_.loading&&(Object(a.a)(e.variables,t.variables)||(r=!0,o=e.variables)),n=r?_.setVariables:t.isPoll?_.poll:t.isRefetch?_.refetch:_.loading;var i=[];e&&e.graphQLErrors&&(i=e.graphQLErrors),this.store[t.queryId]={document:t.document,variables:t.variables,previousVariables:o,networkError:null,graphQLErrors:i,networkStatus:n,metadata:t.metadata},"string"==typeof t.fetchMoreForQueryId&&this.store[t.fetchMoreForQueryId]&&(this.store[t.fetchMoreForQueryId].networkStatus=_.fetchMore)},t.prototype.markQueryResult=function(t,e,n){this.store&&this.store[t]&&(this.store[t].networkError=null,this.store[t].graphQLErrors=q(e.errors)?e.errors:[],this.store[t].previousVariables=null,this.store[t].networkStatus=_.ready,"string"==typeof n&&this.store[n]&&(this.store[n].networkStatus=_.ready))},t.prototype.markQueryError=function(t,e,n){this.store&&this.store[t]&&(this.store[t].networkError=e,this.store[t].networkStatus=_.error,"string"==typeof n&&this.markQueryResultClient(n,!0))},t.prototype.markQueryResultClient=function(t,e){var n=this.store&&this.store[t];n&&(n.networkError=null,n.previousVariables=null,e&&(n.networkStatus=_.ready))},t.prototype.stopQuery=function(t){delete this.store[t]},t.prototype.reset=function(t){var e=this;Object.keys(this.store).forEach((function(n){t.indexOf(n)<0?e.stopQuery(n):e.store[n].networkStatus=_.loading}))},t}();var H=function(){function t(t){var e=t.cache,n=t.client,r=t.resolvers,o=t.fragmentMatcher;this.cache=e,n&&(this.client=n),r&&this.addResolvers(r),o&&this.setFragmentMatcher(o)}return t.prototype.addResolvers=function(t){var e=this;this.resolvers=this.resolvers||{},Array.isArray(t)?t.forEach((function(t){e.resolvers=Object(o.A)(e.resolvers,t)})):this.resolvers=Object(o.A)(this.resolvers,t)},t.prototype.setResolvers=function(t){this.resolvers={},this.addResolvers(t)},t.prototype.getResolvers=function(){return this.resolvers||{}},t.prototype.runResolvers=function(t){var e=t.document,n=t.remoteResult,o=t.context,a=t.variables,i=t.onlyRunForcedResolvers,c=void 0!==i&&i;return Object(r.b)(this,void 0,void 0,(function(){return Object(r.d)(this,(function(t){return e?[2,this.resolveDocument(e,n.data,o,a,this.fragmentMatcher,c).then((function(t){return Object(r.a)(Object(r.a)({},n),{data:t.result})}))]:[2,n]}))}))},t.prototype.setFragmentMatcher=function(t){this.fragmentMatcher=t},t.prototype.getFragmentMatcher=function(){return this.fragmentMatcher},t.prototype.clientQuery=function(t){return Object(o.s)(["client"],t)&&this.resolvers?t:null},t.prototype.serverQuery=function(t){return this.resolvers?Object(o.C)(t):t},t.prototype.prepareContext=function(t){void 0===t&&(t={});var e=this.cache;return Object(r.a)(Object(r.a)({},t),{cache:e,getCacheKey:function(t){if(e.config)return e.config.dataIdFromObject(t);Object(s.b)(!1,6)}})},t.prototype.addExportedVariables=function(t,e,n){return void 0===e&&(e={}),void 0===n&&(n={}),Object(r.b)(this,void 0,void 0,(function(){return Object(r.d)(this,(function(o){return t?[2,this.resolveDocument(t,this.buildRootValueFromCache(t,e)||{},this.prepareContext(n),e).then((function(t){return Object(r.a)(Object(r.a)({},e),t.exportedVariables)}))]:[2,Object(r.a)({},e)]}))}))},t.prototype.shouldForceResolvers=function(t){var e=!1;return Object(z.visit)(t,{Directive:{enter:function(t){if("client"===t.name.value&&t.arguments&&(e=t.arguments.some((function(t){return"always"===t.name.value&&"BooleanValue"===t.value.kind&&!0===t.value.value}))))return z.BREAK}}}),e},t.prototype.buildRootValueFromCache=function(t,e){return this.cache.diff({query:Object(o.d)(t),variables:e,returnPartialData:!0,optimistic:!1}).result},t.prototype.resolveDocument=function(t,e,n,a,i,c){return void 0===n&&(n={}),void 0===a&&(a={}),void 0===i&&(i=function(){return!0}),void 0===c&&(c=!1),Object(r.b)(this,void 0,void 0,(function(){var s,l,u,p,d,h,f,m,g;return Object(r.d)(this,(function(v){var b;return s=Object(o.l)(t),l=Object(o.j)(t),u=Object(o.g)(l),p=s.operation,d=p?(b=p).charAt(0).toUpperCase()+b.slice(1):"Query",f=(h=this).cache,m=h.client,g={fragmentMap:u,context:Object(r.a)(Object(r.a)({},n),{cache:f,client:m}),variables:a,fragmentMatcher:i,defaultOperationType:d,exportedVariables:{},onlyRunForcedResolvers:c},[2,this.resolveSelectionSet(s.selectionSet,e,g).then((function(t){return{result:t,exportedVariables:g.exportedVariables}}))]}))}))},t.prototype.resolveSelectionSet=function(t,e,n){return Object(r.b)(this,void 0,void 0,(function(){var a,i,c,l,u,p=this;return Object(r.d)(this,(function(d){return a=n.fragmentMap,i=n.context,c=n.variables,l=[e],u=function(t){return Object(r.b)(p,void 0,void 0,(function(){var u,p;return Object(r.d)(this,(function(r){return Object(o.F)(t,c)?Object(o.t)(t)?[2,this.resolveField(t,e,n).then((function(e){var n;void 0!==e&&l.push(((n={})[Object(o.E)(t)]=e,n))}))]:(Object(o.v)(t)?u=t:(u=a[t.name.value],Object(s.b)(u,7)),u&&u.typeCondition&&(p=u.typeCondition.name.value,n.fragmentMatcher(e,p,i))?[2,this.resolveSelectionSet(u.selectionSet,e,n).then((function(t){l.push(t)}))]:[2]):[2]}))}))},[2,Promise.all(t.selections.map(u)).then((function(){return Object(o.B)(l)}))]}))}))},t.prototype.resolveField=function(t,e,n){return Object(r.b)(this,void 0,void 0,(function(){var a,i,c,s,l,u,p,d,h,f=this;return Object(r.d)(this,(function(r){return a=n.variables,i=t.name.value,c=Object(o.E)(t),s=i!==c,l=e[c]||e[i],u=Promise.resolve(l),n.onlyRunForcedResolvers&&!this.shouldForceResolvers(t)||(p=e.__typename||n.defaultOperationType,(d=this.resolvers&&this.resolvers[p])&&(h=d[s?i:c])&&(u=Promise.resolve(h(e,Object(o.b)(t,a),n.context,{field:t,fragmentMap:n.fragmentMap})))),[2,u.then((function(e){return void 0===e&&(e=l),t.directives&&t.directives.forEach((function(t){"export"===t.name.value&&t.arguments&&t.arguments.forEach((function(t){"as"===t.name.value&&"StringValue"===t.value.kind&&(n.exportedVariables[t.value.value]=e)}))})),t.selectionSet?null==e?e:Array.isArray(e)?f.resolveSubSelectedArray(t,e,n):t.selectionSet?f.resolveSelectionSet(t.selectionSet,e,n):void 0:e}))]}))}))},t.prototype.resolveSubSelectedArray=function(t,e,n){var r=this;return Promise.all(e.map((function(e){return null===e?null:Array.isArray(e)?r.resolveSubSelectedArray(t,e,n):t.selectionSet?r.resolveSelectionSet(t.selectionSet,e,n):void 0})))},t}();function D(t){var e=new Set,n=null;return new M((function(r){return e.add(r),n=n||t.subscribe({next:function(t){e.forEach((function(e){return e.next&&e.next(t)}))},error:function(t){e.forEach((function(e){return e.error&&e.error(t)}))},complete:function(){e.forEach((function(t){return t.complete&&t.complete()}))}}),function(){e.delete(r)&&!e.size&&n&&(n.unsubscribe(),n=null)}}))}var B=Object.prototype.hasOwnProperty,V=function(){function t(t){var e=t.link,n=t.queryDeduplication,r=void 0!==n&&n,a=t.store,i=t.onBroadcast,c=void 0===i?function(){}:i,s=t.ssrMode,l=void 0!==s&&s,u=t.clientAwareness,p=void 0===u?{}:u,d=t.localState,h=t.assumeImmutableResults;this.mutationStore=new F,this.queryStore=new I,this.clientAwareness={},this.idCounter=1,this.queries=new Map,this.fetchQueryRejectFns=new Map,this.transformCache=new(o.e?WeakMap:Map),this.inFlightLinkObservables=new Map,this.pollingInfoByQueryId=new Map,this.link=e,this.queryDeduplication=r,this.dataStore=a,this.onBroadcast=c,this.clientAwareness=p,this.localState=d||new H({cache:a.getCache()}),this.ssrMode=l,this.assumeImmutableResults=!!h}return t.prototype.stop=function(){var t=this;this.queries.forEach((function(e,n){t.stopQueryNoBroadcast(n)})),this.fetchQueryRejectFns.forEach((function(t){t(new s.a(8))}))},t.prototype.mutate=function(t){var e=t.mutation,n=t.variables,a=t.optimisticResponse,i=t.updateQueries,c=t.refetchQueries,l=void 0===c?[]:c,u=t.awaitRefetchQueries,p=void 0!==u&&u,d=t.update,h=t.errorPolicy,f=void 0===h?"none":h,m=t.fetchPolicy,g=t.context,v=void 0===g?{}:g;return Object(r.b)(this,void 0,void 0,(function(){var t,c,u,h=this;return Object(r.d)(this,(function(g){switch(g.label){case 0:return Object(s.b)(e,9),Object(s.b)(!m||"no-cache"===m,10),t=this.generateQueryId(),e=this.transform(e).document,this.setQuery(t,(function(){return{document:e}})),n=this.getVariables(e,n),this.transform(e).hasClientExports?[4,this.localState.addExportedVariables(e,n,v)]:[3,2];case 1:n=g.sent(),g.label=2;case 2:return c=function(){var t={};return i&&h.queries.forEach((function(e,n){var r=e.observableQuery;if(r){var o=r.queryName;o&&B.call(i,o)&&(t[n]={updater:i[o],query:h.queryStore.get(n)})}})),t},this.mutationStore.initMutation(t,e,n),this.dataStore.markMutationInit({mutationId:t,document:e,variables:n,updateQueries:c(),update:d,optimisticResponse:a}),this.broadcastQueries(),u=this,[2,new Promise((function(i,s){var h,g;u.getObservableFromLink(e,Object(r.a)(Object(r.a)({},v),{optimisticResponse:a}),n,!1).subscribe({next:function(r){Object(o.q)(r)&&"none"===f?g=new L({graphQLErrors:r.errors}):(u.mutationStore.markMutationResult(t),"no-cache"!==m&&u.dataStore.markMutationResult({mutationId:t,result:r,document:e,variables:n,updateQueries:c(),update:d}),h=r)},error:function(e){u.mutationStore.markMutationError(t,e),u.dataStore.markMutationComplete({mutationId:t,optimisticResponse:a}),u.broadcastQueries(),u.setQuery(t,(function(){return{document:null}})),s(new L({networkError:e}))},complete:function(){if(g&&u.mutationStore.markMutationError(t,g),u.dataStore.markMutationComplete({mutationId:t,optimisticResponse:a}),u.broadcastQueries(),g)s(g);else{"function"==typeof l&&(l=l(h));var e=[];q(l)&&l.forEach((function(t){if("string"==typeof t)u.queries.forEach((function(n){var r=n.observableQuery;r&&r.queryName===t&&e.push(r.refetch())}));else{var n={query:t.query,variables:t.variables,fetchPolicy:"network-only"};t.context&&(n.context=t.context),e.push(u.query(n))}})),Promise.all(p?e:[]).then((function(){u.setQuery(t,(function(){return{document:null}})),"ignore"===f&&h&&Object(o.q)(h)&&delete h.errors,i(h)}))}}})}))]}}))}))},t.prototype.fetchQuery=function(t,e,n,a){return Object(r.b)(this,void 0,void 0,(function(){var i,c,s,l,u,p,d,h,f,m,g,v,b,y,S,C,x,_,w=this;return Object(r.d)(this,(function(z){switch(z.label){case 0:return i=e.metadata,c=void 0===i?null:i,s=e.fetchPolicy,l=void 0===s?"cache-first":s,u=e.context,p=void 0===u?{}:u,d=this.transform(e.query).document,h=this.getVariables(d,e.variables),this.transform(d).hasClientExports?[4,this.localState.addExportedVariables(d,h,p)]:[3,2];case 1:h=z.sent(),z.label=2;case 2:if(e=Object(r.a)(Object(r.a)({},e),{variables:h}),g=m="network-only"===l||"no-cache"===l,m||(v=this.dataStore.getCache().diff({query:d,variables:h,returnPartialData:!0,optimistic:!1}),b=v.complete,y=v.result,g=!b||"cache-and-network"===l,f=y),S=g&&"cache-only"!==l&&"standby"!==l,Object(o.s)(["live"],d)&&(S=!0),C=this.idCounter++,x="no-cache"!==l?this.updateQueryWatch(t,d,e):void 0,this.setQuery(t,(function(){return{document:d,lastRequestId:C,invalidated:!0,cancel:x}})),this.invalidate(a),this.queryStore.initQuery({queryId:t,document:d,storePreviousVariables:S,variables:h,isPoll:n===G.poll,isRefetch:n===G.refetch,metadata:c,fetchMoreForQueryId:a}),this.broadcastQueries(),S){if(_=this.fetchRequest({requestId:C,queryId:t,document:d,options:e,fetchMoreForQueryId:a}).catch((function(e){throw k(e)?e:(C>=w.getQuery(t).lastRequestId&&(w.queryStore.markQueryError(t,e,a),w.invalidate(t),w.invalidate(a),w.broadcastQueries()),new L({networkError:e}))})),"cache-and-network"!==l)return[2,_];_.catch((function(){}))}return this.queryStore.markQueryResultClient(t,!S),this.invalidate(t),this.invalidate(a),this.transform(d).hasForcedResolvers?[2,this.localState.runResolvers({document:d,remoteResult:{data:f},context:p,variables:h,onlyRunForcedResolvers:!0}).then((function(n){return w.markQueryResult(t,n,e,a),w.broadcastQueries(),n}))]:(this.broadcastQueries(),[2,{data:f}])}}))}))},t.prototype.markQueryResult=function(t,e,n,r){var o=n.fetchPolicy,a=n.variables,i=n.errorPolicy;"no-cache"===o?this.setQuery(t,(function(){return{newData:{result:e.data,complete:!0}}})):this.dataStore.markQueryResult(e,this.getQuery(t).document,a,r,"ignore"===i||"all"===i)},t.prototype.queryListenerForObserver=function(t,e,n){var r=this;function o(t,e){if(n[t])try{n[t](e)}catch(t){}}return function(n,a){if(r.invalidate(t,!1),n){var i=r.getQuery(t),c=i.observableQuery,s=i.document,l=c?c.options.fetchPolicy:e.fetchPolicy;if("standby"!==l){var u=E(n.networkStatus),p=c&&c.getLastResult(),d=!(!p||p.networkStatus===n.networkStatus),h=e.returnPartialData||!a&&n.previousVariables||d&&e.notifyOnNetworkStatusChange||"cache-only"===l||"cache-and-network"===l;if(!u||h){var f=q(n.graphQLErrors),m=c&&c.options.errorPolicy||e.errorPolicy||"none";if("none"===m&&f||n.networkError)return o("error",new L({graphQLErrors:n.graphQLErrors,networkError:n.networkError}));try{var g=void 0,v=void 0;if(a)"no-cache"!==l&&"network-only"!==l&&r.setQuery(t,(function(){return{newData:null}})),g=a.result,v=!a.complete;else{var b=c&&c.getLastError(),y="none"!==m&&(b&&b.graphQLErrors)!==n.graphQLErrors;if(p&&p.data&&!y)g=p.data,v=!1;else{var S=r.dataStore.getCache().diff({query:s,variables:n.previousVariables||n.variables,returnPartialData:!0,optimistic:!0});g=S.result,v=!S.complete}}var C=v&&!(e.returnPartialData||"cache-only"===l),x={data:C?p&&p.data:g,loading:u,networkStatus:n.networkStatus,stale:C};"all"===m&&f&&(x.errors=n.graphQLErrors),o("next",x)}catch(t){o("error",new L({networkError:t}))}}}}}},t.prototype.transform=function(t){var e=this.transformCache;if(!e.has(t)){var n=this.dataStore.getCache(),r=n.transformDocument(t),a=Object(o.D)(n.transformForLink(r)),i=this.localState.clientQuery(r),c=this.localState.serverQuery(a),s={document:r,hasClientExports:Object(o.r)(r),hasForcedResolvers:this.localState.shouldForceResolvers(r),clientQuery:i,serverQuery:c,defaultVars:Object(o.h)(Object(o.m)(r))},l=function(t){t&&!e.has(t)&&e.set(t,s)};l(t),l(r),l(i),l(c)}return e.get(t)},t.prototype.getVariables=function(t,e){return Object(r.a)(Object(r.a)({},this.transform(t).defaultVars),e)},t.prototype.watchQuery=function(t,e){void 0===e&&(e=!0),Object(s.b)("standby"!==t.fetchPolicy,11),t.variables=this.getVariables(t.query,t.variables),void 0===t.notifyOnNetworkStatusChange&&(t.notifyOnNetworkStatusChange=!1);var n=Object(r.a)({},t);return new O({queryManager:this,options:n,shouldSubscribe:e})},t.prototype.query=function(t){var e=this;return Object(s.b)(t.query,12),Object(s.b)("Document"===t.query.kind,13),Object(s.b)(!t.returnPartialData,14),Object(s.b)(!t.pollInterval,15),new Promise((function(n,r){var o=e.watchQuery(t,!1);e.fetchQueryRejectFns.set("query:"+o.queryId,r),o.result().then(n,r).then((function(){return e.fetchQueryRejectFns.delete("query:"+o.queryId)}))}))},t.prototype.generateQueryId=function(){return String(this.idCounter++)},t.prototype.stopQueryInStore=function(t){this.stopQueryInStoreNoBroadcast(t),this.broadcastQueries()},t.prototype.stopQueryInStoreNoBroadcast=function(t){this.stopPollingQuery(t),this.queryStore.stopQuery(t),this.invalidate(t)},t.prototype.addQueryListener=function(t,e){this.setQuery(t,(function(t){return t.listeners.add(e),{invalidated:!1}}))},t.prototype.updateQueryWatch=function(t,e,n){var r=this,o=this.getQuery(t).cancel;o&&o();return this.dataStore.getCache().watch({query:e,variables:n.variables,optimistic:!0,previousResult:function(){var e=null,n=r.getQuery(t).observableQuery;if(n){var o=n.getLastResult();o&&(e=o.data)}return e},callback:function(e){r.setQuery(t,(function(){return{invalidated:!0,newData:e}}))}})},t.prototype.addObservableQuery=function(t,e){this.setQuery(t,(function(){return{observableQuery:e}}))},t.prototype.removeObservableQuery=function(t){var e=this.getQuery(t).cancel;this.setQuery(t,(function(){return{observableQuery:null}})),e&&e()},t.prototype.clearStore=function(){this.fetchQueryRejectFns.forEach((function(t){t(new s.a(16))}));var t=[];return this.queries.forEach((function(e,n){e.observableQuery&&t.push(n)})),this.queryStore.reset(t),this.mutationStore.reset(),this.dataStore.reset()},t.prototype.resetStore=function(){var t=this;return this.clearStore().then((function(){return t.reFetchObservableQueries()}))},t.prototype.reFetchObservableQueries=function(t){var e=this;void 0===t&&(t=!1);var n=[];return this.queries.forEach((function(r,o){var a=r.observableQuery;if(a){var i=a.options.fetchPolicy;a.resetLastResults(),"cache-only"===i||!t&&"standby"===i||n.push(a.refetch()),e.setQuery(o,(function(){return{newData:null}})),e.invalidate(o)}})),this.broadcastQueries(),Promise.all(n)},t.prototype.observeQuery=function(t,e,n){return this.addQueryListener(t,this.queryListenerForObserver(t,e,n)),this.fetchQuery(t,e)},t.prototype.startQuery=function(t,e,n){return this.addQueryListener(t,n),this.fetchQuery(t,e).catch((function(){})),t},t.prototype.startGraphQLSubscription=function(t){var e=this,n=t.query,r=t.fetchPolicy,a=t.variables;n=this.transform(n).document,a=this.getVariables(n,a);var i=function(t){return e.getObservableFromLink(n,{},t,!1).map((function(a){if(r&&"no-cache"===r||(e.dataStore.markSubscriptionResult(a,n,t),e.broadcastQueries()),Object(o.q)(a))throw new L({graphQLErrors:a.errors});return a}))};if(this.transform(n).hasClientExports){var c=this.localState.addExportedVariables(n,a).then(i);return new M((function(t){var e=null;return c.then((function(n){return e=n.subscribe(t)}),t.error),function(){return e&&e.unsubscribe()}}))}return i(a)},t.prototype.stopQuery=function(t){this.stopQueryNoBroadcast(t),this.broadcastQueries()},t.prototype.stopQueryNoBroadcast=function(t){this.stopQueryInStoreNoBroadcast(t),this.removeQuery(t)},t.prototype.removeQuery=function(t){this.fetchQueryRejectFns.delete("query:"+t),this.fetchQueryRejectFns.delete("fetchRequest:"+t),this.getQuery(t).subscriptions.forEach((function(t){return t.unsubscribe()})),this.queries.delete(t)},t.prototype.getCurrentQueryResult=function(t,e){void 0===e&&(e=!0);var n=t.options,r=n.variables,o=n.query,a=n.fetchPolicy,i=n.returnPartialData,c=t.getLastResult(),s=this.getQuery(t.queryId).newData;if(s&&s.complete)return{data:s.result,partial:!1};if("no-cache"===a||"network-only"===a)return{data:void 0,partial:!1};var l=this.dataStore.getCache().diff({query:o,variables:r,previousResult:c?c.data:void 0,returnPartialData:!0,optimistic:e}),u=l.result,p=l.complete;return{data:p||i?u:void 0,partial:!p}},t.prototype.getQueryWithPreviousResult=function(t){var e;if("string"==typeof t){var n=this.getQuery(t).observableQuery;Object(s.b)(n,17),e=n}else e=t;var r=e.options,o=r.variables,a=r.query;return{previousResult:this.getCurrentQueryResult(e,!1).data,variables:o,document:a}},t.prototype.broadcastQueries=function(){var t=this;this.onBroadcast(),this.queries.forEach((function(e,n){e.invalidated&&e.listeners.forEach((function(r){r&&r(t.queryStore.get(n),e.newData)}))}))},t.prototype.getLocalState=function(){return this.localState},t.prototype.getObservableFromLink=function(t,e,n,a){var i,c=this;void 0===a&&(a=this.queryDeduplication);var s=this.transform(t).serverQuery;if(s){var l=this.inFlightLinkObservables,u=this.link,p={query:s,variables:n,operationName:Object(o.n)(s)||void 0,context:this.prepareContext(Object(r.a)(Object(r.a)({},e),{forceFetch:!a}))};if(e=p.context,a){var d=l.get(s)||new Map;l.set(s,d);var h=JSON.stringify(n);if(!(i=d.get(h))){d.set(h,i=D(x(u,p)));var f=function(){d.delete(h),d.size||l.delete(s),m.unsubscribe()},m=i.subscribe({next:f,error:f,complete:f})}}else i=D(x(u,p))}else i=M.of({data:{}}),e=this.prepareContext(e);var g=this.transform(t).clientQuery;return g&&(i=function(t,e){return new M((function(n){var r=n.next,o=n.error,a=n.complete,i=0,c=!1,s={next:function(t){++i,new Promise((function(n){n(e(t))})).then((function(t){--i,r&&r.call(n,t),c&&s.complete()}),(function(t){--i,o&&o.call(n,t)}))},error:function(t){o&&o.call(n,t)},complete:function(){c=!0,i||a&&a.call(n)}},l=t.subscribe(s);return function(){return l.unsubscribe()}}))}(i,(function(t){return c.localState.runResolvers({document:g,remoteResult:t,context:e,variables:n})}))),i},t.prototype.fetchRequest=function(t){var e,n,r=this,o=t.requestId,a=t.queryId,i=t.document,c=t.options,s=t.fetchMoreForQueryId,l=c.variables,u=c.errorPolicy,p=void 0===u?"none":u,d=c.fetchPolicy;return new Promise((function(t,u){var h=r.getObservableFromLink(i,c.context,l),f="fetchRequest:"+a;r.fetchQueryRejectFns.set(f,u);var m=function(){r.fetchQueryRejectFns.delete(f),r.setQuery(a,(function(t){t.subscriptions.delete(g)}))},g=h.map((function(t){if(o>=r.getQuery(a).lastRequestId&&(r.markQueryResult(a,t,c,s),r.queryStore.markQueryResult(a,t,s),r.invalidate(a),r.invalidate(s),r.broadcastQueries()),"none"===p&&q(t.errors))return u(new L({graphQLErrors:t.errors}));if("all"===p&&(n=t.errors),s||"no-cache"===d)e=t.data;else{var h=r.dataStore.getCache().diff({variables:l,query:i,optimistic:!1,returnPartialData:!0}),f=h.result;(h.complete||c.returnPartialData)&&(e=f)}})).subscribe({error:function(t){m(),u(t)},complete:function(){m(),t({data:e,errors:n,loading:!1,networkStatus:_.ready,stale:!1})}});r.setQuery(a,(function(t){t.subscriptions.add(g)}))}))},t.prototype.getQuery=function(t){return this.queries.get(t)||{listeners:new Set,invalidated:!1,document:null,newData:null,lastRequestId:1,observableQuery:null,subscriptions:new Set}},t.prototype.setQuery=function(t,e){var n=this.getQuery(t),o=Object(r.a)(Object(r.a)({},n),e(n));this.queries.set(t,o)},t.prototype.invalidate=function(t,e){void 0===e&&(e=!0),t&&this.setQuery(t,(function(){return{invalidated:e}}))},t.prototype.prepareContext=function(t){void 0===t&&(t={});var e=this.localState.prepareContext(t);return Object(r.a)(Object(r.a)({},e),{clientAwareness:this.clientAwareness})},t.prototype.checkInFlight=function(t){var e=this.queryStore.get(t);return e&&e.networkStatus!==_.ready&&e.networkStatus!==_.error},t.prototype.startPollingQuery=function(t,e,n){var o=this,a=t.pollInterval;if(Object(s.b)(a,18),!this.ssrMode){var i=this.pollingInfoByQueryId.get(e);i||this.pollingInfoByQueryId.set(e,i={}),i.interval=a,i.options=Object(r.a)(Object(r.a)({},t),{fetchPolicy:"network-only"});var c=function(){var t=o.pollingInfoByQueryId.get(e);t&&(o.checkInFlight(e)?l():o.fetchQuery(e,t.options,G.poll).then(l,l))},l=function(){var t=o.pollingInfoByQueryId.get(e);t&&(clearTimeout(t.timeout),t.timeout=setTimeout(c,t.interval))};n&&this.addQueryListener(e,n),l()}return e},t.prototype.stopPollingQuery=function(t){this.pollingInfoByQueryId.delete(t)},t}(),N=function(){function t(t){this.cache=t}return t.prototype.getCache=function(){return this.cache},t.prototype.markQueryResult=function(t,e,n,r,a){void 0===a&&(a=!1);var i=!Object(o.q)(t);a&&Object(o.q)(t)&&t.data&&(i=!0),!r&&i&&this.cache.write({result:t.data,dataId:"ROOT_QUERY",query:e,variables:n})},t.prototype.markSubscriptionResult=function(t,e,n){Object(o.q)(t)||this.cache.write({result:t.data,dataId:"ROOT_SUBSCRIPTION",query:e,variables:n})},t.prototype.markMutationInit=function(t){var e,n=this;t.optimisticResponse&&(e="function"==typeof t.optimisticResponse?t.optimisticResponse(t.variables):t.optimisticResponse,this.cache.recordOptimisticTransaction((function(r){var o=n.cache;n.cache=r;try{n.markMutationResult({mutationId:t.mutationId,result:{data:e},document:t.document,variables:t.variables,updateQueries:t.updateQueries,update:t.update})}finally{n.cache=o}}),t.mutationId))},t.prototype.markMutationResult=function(t){var e=this;if(!Object(o.q)(t.result)){var n=[{result:t.result.data,dataId:"ROOT_MUTATION",query:t.document,variables:t.variables}],r=t.updateQueries;r&&Object.keys(r).forEach((function(a){var i=r[a],c=i.query,s=i.updater,l=e.cache.diff({query:c.document,variables:c.variables,returnPartialData:!0,optimistic:!1}),u=l.result;if(l.complete){var p=Object(o.I)((function(){return s(u,{mutationResult:t.result,queryName:Object(o.n)(c.document)||void 0,queryVariables:c.variables})}));p&&n.push({result:p,dataId:"ROOT_QUERY",query:c.document,variables:c.variables})}})),this.cache.performTransaction((function(e){n.forEach((function(t){return e.write(t)}));var r=t.update;r&&Object(o.I)((function(){return r(e,t.result)}))}))}},t.prototype.markMutationComplete=function(t){var e=t.mutationId;t.optimisticResponse&&this.cache.removeOptimistic(e)},t.prototype.markUpdateQueryResult=function(t,e,n){this.cache.write({result:n,dataId:"ROOT_QUERY",variables:e,query:t})},t.prototype.reset=function(){return this.cache.reset()},t}(),P=function(){function t(t){var e=this;this.defaultOptions={},this.resetStoreCallbacks=[],this.clearStoreCallbacks=[];var n=t.cache,r=t.ssrMode,o=void 0!==r&&r,a=t.ssrForceFetchDelay,i=void 0===a?0:a,c=t.connectToDevTools,l=t.queryDeduplication,u=void 0===l||l,p=t.defaultOptions,d=t.assumeImmutableResults,h=void 0!==d&&d,f=t.resolvers,m=t.typeDefs,g=t.fragmentMatcher,v=t.name,b=t.version,y=t.link;if(!y&&f&&(y=C.empty()),!y||!n)throw new s.a(4);this.link=y,this.cache=n,this.store=new N(n),this.disableNetworkFetches=o||i>0,this.queryDeduplication=u,this.defaultOptions=p||{},this.typeDefs=m,i&&setTimeout((function(){return e.disableNetworkFetches=!1}),i),this.watchQuery=this.watchQuery.bind(this),this.query=this.query.bind(this),this.mutate=this.mutate.bind(this),this.resetStore=this.resetStore.bind(this),this.reFetchObservableQueries=this.reFetchObservableQueries.bind(this);void 0!==c&&(c&&"undefined"!=typeof window)&&(window.__APOLLO_CLIENT__=this),this.version="2.6.10",this.localState=new H({cache:n,client:this,resolvers:f,fragmentMatcher:g}),this.queryManager=new V({link:this.link,store:this.store,queryDeduplication:u,ssrMode:o,clientAwareness:{name:v,version:b},localState:this.localState,assumeImmutableResults:h,onBroadcast:function(){e.devToolsHookCb&&e.devToolsHookCb({action:{},state:{queries:e.queryManager.queryStore.getStore(),mutations:e.queryManager.mutationStore.getStore()},dataWithOptimisticResults:e.cache.extract(!0)})}})}return t.prototype.stop=function(){this.queryManager.stop()},t.prototype.watchQuery=function(t){return this.defaultOptions.watchQuery&&(t=Object(r.a)(Object(r.a)({},this.defaultOptions.watchQuery),t)),!this.disableNetworkFetches||"network-only"!==t.fetchPolicy&&"cache-and-network"!==t.fetchPolicy||(t=Object(r.a)(Object(r.a)({},t),{fetchPolicy:"cache-first"})),this.queryManager.watchQuery(t)},t.prototype.query=function(t){return this.defaultOptions.query&&(t=Object(r.a)(Object(r.a)({},this.defaultOptions.query),t)),Object(s.b)("cache-and-network"!==t.fetchPolicy,5),this.disableNetworkFetches&&"network-only"===t.fetchPolicy&&(t=Object(r.a)(Object(r.a)({},t),{fetchPolicy:"cache-first"})),this.queryManager.query(t)},t.prototype.mutate=function(t){return this.defaultOptions.mutate&&(t=Object(r.a)(Object(r.a)({},this.defaultOptions.mutate),t)),this.queryManager.mutate(t)},t.prototype.subscribe=function(t){return this.queryManager.startGraphQLSubscription(t)},t.prototype.readQuery=function(t,e){return void 0===e&&(e=!1),this.cache.readQuery(t,e)},t.prototype.readFragment=function(t,e){return void 0===e&&(e=!1),this.cache.readFragment(t,e)},t.prototype.writeQuery=function(t){var e=this.cache.writeQuery(t);return this.queryManager.broadcastQueries(),e},t.prototype.writeFragment=function(t){var e=this.cache.writeFragment(t);return this.queryManager.broadcastQueries(),e},t.prototype.writeData=function(t){var e=this.cache.writeData(t);return this.queryManager.broadcastQueries(),e},t.prototype.__actionHookForDevTools=function(t){this.devToolsHookCb=t},t.prototype.__requestRaw=function(t){return x(this.link,t)},t.prototype.initQueryManager=function(){return this.queryManager},t.prototype.resetStore=function(){var t=this;return Promise.resolve().then((function(){return t.queryManager.clearStore()})).then((function(){return Promise.all(t.resetStoreCallbacks.map((function(t){return t()})))})).then((function(){return t.reFetchObservableQueries()}))},t.prototype.clearStore=function(){var t=this;return Promise.resolve().then((function(){return t.queryManager.clearStore()})).then((function(){return Promise.all(t.clearStoreCallbacks.map((function(t){return t()})))}))},t.prototype.onResetStore=function(t){var e=this;return this.resetStoreCallbacks.push(t),function(){e.resetStoreCallbacks=e.resetStoreCallbacks.filter((function(e){return e!==t}))}},t.prototype.onClearStore=function(t){var e=this;return this.clearStoreCallbacks.push(t),function(){e.clearStoreCallbacks=e.clearStoreCallbacks.filter((function(e){return e!==t}))}},t.prototype.reFetchObservableQueries=function(t){return this.queryManager.reFetchObservableQueries(t)},t.prototype.extract=function(t){return this.cache.extract(t)},t.prototype.restore=function(t){return this.cache.restore(t)},t.prototype.addResolvers=function(t){this.localState.addResolvers(t)},t.prototype.setResolvers=function(t){this.localState.setResolvers(t)},t.prototype.getResolvers=function(){return 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e=this,n=t.selectionSet,a=t.rootValue,i=t.execContext,c=i.fragmentMap,l=i.contextValue,u=i.variableValues,p={result:null},d=[],h=l.store.get(a.id),f=h&&h.__typename||"ROOT_QUERY"===a.id&&"Query"||void 0;function m(t){var e;return t.missing&&(p.missing=p.missing||[],(e=p.missing).push.apply(e,t.missing)),t.result}return n.selections.forEach((function(t){var n;if(Object(o.F)(t,u))if(Object(o.t)(t)){var p=m(e.executeField(h,f,t,i));void 0!==p&&d.push(((n={})[Object(o.E)(t)]=p,n))}else{var g=void 0;if(Object(o.v)(t))g=t;else if(!(g=c[t.name.value]))throw new s.a(9);var v=g.typeCondition&&g.typeCondition.name.value,b=!v||i.fragmentMatcher(a,v,l);if(b){var y=e.executeSelectionSet({selectionSet:g.selectionSet,rootValue:a,execContext:i});"heuristic"===b&&y.missing&&(y=Object(r.a)(Object(r.a)({},y),{missing:y.missing.map((function(t){return 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Array.isArray(c.result)?this.combineExecResults(c,this.executeSubSelectedArray({field:n,array:c.result,execContext:r})):n.selectionSet?null==c.result?c:this.combineExecResults(c,this.executeSelectionSet({selectionSet:n.selectionSet,rootValue:c.result,execContext:r})):(Tt(n,c.result),this.freezeResults,c)},t.prototype.combineExecResults=function(){for(var t,e=[],n=0;n<arguments.length;n++)e[n]=arguments[n];return e.forEach((function(e){e.missing&&(t=t||[]).push.apply(t,e.missing)})),{result:e.pop().result,missing:t}},t.prototype.executeSubSelectedArray=function(t){var e,n=this,r=t.field,o=t.array,a=t.execContext;function i(t){return t.missing&&(e=e||[]).push.apply(e,t.missing),t.result}return o=o.map((function(t){return null===t?null:Array.isArray(t)?i(n.executeSubSelectedArray({field:r,array:t,execContext:a})):r.selectionSet?i(n.executeSelectionSet({selectionSet:r.selectionSet,rootValue:t,execContext:a})):(Tt(r,t),t)})),this.freezeResults,{result:o,missing:e}},t}();function 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i.createElement(c.components.SingleValue,Object.assign({},t),e)},Option:null!==(n=this.props.optionProps)&&void 0!==n?n:t=>i.createElement(c.components.Option,Object.assign({},t))},defaultValue:Object.assign(Object.assign({},t),{value:e})}))}configStyle(){return{control:t=>{var e;return Object.assign(Object.assign({},t),{width:null!==(e=this.props.width)&&void 0!==e?e:120,border:"1px solid #ddd",boxShadow:"none","&:hover":{border:"1px solid #ddd"}})},menu:t=>Object.assign(Object.assign({},t),{width:500}),option:t=>Object.assign({},t)}}getSelectOpt(){let t,e=0;if(null!=this.defaultValue){if(null==this.props.options[0].options){const n=this.props.options.findIndex(t=>t.optId===this.defaultValue);n>=0&&(e=n,t=this.props.options[n])}else if(null!=this.props.options[0].options){let n=!1;for(const r of this.props.options){for(const o of r.options){if(o.optId===this.defaultValue){t=o,n=!0;break}e++}if(n)break}}}else 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o(e,t),e};Object.defineProperty(e,"__esModule",{value:!0}),e.GroupSequenceTabs=void 0;const i=a(n(0)),c=n(106),s=n(7),l=n(16),u=n(46),p=n(114),d=n(25),h=n(117),f=n(121);class m extends i.Component{constructor(t){super(t),this.rendered=new Set,this.filterInstances=void 0,this.filterEntities=void 0}render(){return i.createElement(i.Fragment,null,i.createElement(h.RcsbTabs,{id:"group-id",tabList:[{key:"alignment",title:"ALIGNMENTS"},{key:"structural-features",title:"STRUCTURAL FEATURES"},{key:"binding-sites",title:"BINDING SITES"}],default:"alignment",onMount:this.onMount.bind(this),onSelect:this.onSelect.bind(this)}))}onMount(){if(this.props.searchQuery){const t=new u.SearchRequestProperty;t.requestMembers(Object.assign(Object.assign({},this.props.searchQuery),{query:p.addGroupNodeToSearchQuery(this.props.groupGranularity,this.props.groupId,this.props.searchQuery),return_type:d.ReturnType.PolymerEntity})).then(e=>{this.filterEntities=e,t.requestMembers(Object.assign(Object.assign({},this.props.searchQuery),{query:p.addGroupNodeToSearchQuery(this.props.groupGranularity,this.props.groupId,this.props.searchQuery),return_type:d.ReturnType.PolymerInstance})).then(t=>{this.filterInstances=t,this.onSelect("alignment")})})}else{this.onSelect("alignment"),(new u.SearchRequestProperty).requestMembers({query:p.searchGroupQuery(this.props.groupGranularity,this.props.groupId),return_type:d.ReturnType.PolymerInstance}).then(t=>{this.filterInstances=t,this.onSelect("alignment")})}}onSelect(t){var e,n,r,o;if(!this.rendered.has(t))switch(this.rendered.add(t),t){case"alignment":e=t.toString(),n=this.props.groupGranularity,r=this.props.groupId,o={page:{first:100,after:"0"},alignmentFilter:this.filterEntities},c.RcsbFvGroupBuilder.buildGroupAlignmentFv(e,n,r,s.SequenceReference.PdbEntity,s.SequenceReference.Uniprot,Object.assign(Object.assign({},o),{boardConfig:{rowTitleWidth:190},externalTrackBuilder:S()}));break;case"binding-sites":this.props.searchQuery?g(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"},alignmentFilter:this.filterEntities,filters:[{field:s.FieldName.TargetId,operation:s.OperationType.Equals,values:this.filterInstances}]}):g(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"}});break;case"structural-features":this.props.searchQuery?v(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"},alignmentFilter:this.filterEntities,filters:[{field:s.FieldName.TargetId,operation:s.OperationType.Equals,values:this.filterInstances}]}):v(t.toString(),this.props.groupGranularity,this.props.groupId,this.filterInstances.length,{page:{first:0,after:"0"}})}}}e.GroupSequenceTabs=m;function g(t,e,n,r,o){var a;return c.RcsbFvGroupBuilder.buildGroupAnnotationFv(t,e,n,s.SequenceReference.PdbEntity,s.SequenceReference.Uniprot,Object.assign(Object.assign({},o),{boardConfig:{rowTitleWidth:190},filters:[...null!==(a=null==o?void 0:o.filters)&&void 0!==a?a:[],{field:s.FieldName.Type,values:[s.Type.BindingSite],operation:s.OperationType.Equals,source:s.Source.PdbInstance}],sources:[s.Source.PdbInstance],annotationProcessing:b(r),externalTrackBuilder:y()}))}function v(t,e,n,r,o){var a;return c.RcsbFvGroupBuilder.buildGroupAnnotationFv(t,e,n,s.SequenceReference.PdbEntity,s.SequenceReference.Uniprot,Object.assign(Object.assign({},o),{boardConfig:{rowTitleWidth:150},filters:[...null!==(a=null==o?void 0:o.filters)&&void 0!==a?a:[],{field:s.FieldName.Type,values:[s.Type.HelixP,s.Type.Sheet,s.Type.Cath,s.Type.Scop],operation:s.OperationType.Equals,source:s.Source.PdbInstance},{field:s.FieldName.Type,values:[s.Type.Pfam],operation:s.OperationType.Equals,source:s.Source.PdbEntity}],sources:[s.Source.PdbInstance,s.Source.PdbEntity],annotationProcessing:b(r),externalTrackBuilder:S()}))}function b(t){const e=new Map,n=t;return{getAnnotationValue:t=>(e.has(t.type)||e.set(t.type,t.d.value),t.p.values[0]),computeAnnotationValue:t=>{t.forEach((t,r)=>{const o=r.includes(s.Type.Cath)||r.includes(s.Type.Scop)||r.includes(s.Type.BindingSite)?e.get(r):n;t.forEach((t,e)=>{t.value=Math.ceil(1e3*t.value/o)/1e3})})}}}function y(){const t=new Map;let e=0;const n=S();return{addTo(r){r.annotationTracks.unshift({trackId:"annotationTrack_GLOBAL_BINDINGS",trackHeight:40,displayType:"area",trackColor:"#F9F9F9",displayColor:"#c4124b",titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:"GLOBAL BINDINGS",displayDomain:[0,e],interpolationType:"step",trackData:Array.from(t.values())}),n.addTo(r)},processAlignmentAndFeatures(r){r.annotations.forEach(n=>{n.features.forEach(n=>{n.feature_positions.forEach(n=>{n.values.forEach((r,o)=>{const a=(n.beg_seq_id+o).toString();t.has(a)?(t.get(a).value+=r,t.get(a).value>e&&(e=t.get(a).value)):(t.set(a,{begin:n.beg_seq_id+o,type:"GLOBAL BINDINGS",value:r}),0==e&&(e=r))})})})}),n.processAlignmentAndFeatures(r)},filterFeatures:t=>(t.forEach(t=>{t.features=t.features.filter(t=>t.name.includes("ligand"))}),new Promise(e=>{e(t)}))}}function S(){let t=new Array;return{addTo(e){e.alignmentTracks.sequence||(e.alignmentTracks.sequence=[{trackId:"annotationTrack_ALIGNMENT_MODE",displayType:"sequence",trackColor:"#F9F9F9",titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:"ALIGNMENT MODE",nonEmptyDisplay:!0,trackData:t.map((t,e)=>({begin:e+1,value:t.mode(),description:[t.frequency().filter(t=>t.value>=.01).map(t=>t.symbol.replace("-","gap")+": "+Math.trunc(100*t.value)/100).join(", ")]}))},{trackId:"annotationTrack_ALIGNMENT_FREQ",displayType:"multi-area",trackColor:"#F9F9F9",displayColor:{thresholds:[],colors:["#5289e9","#76bbf6","#91cef6","#b9d9f8","#d6eafd","#e6f5fd","#f9f9f9"]},trackHeight:20,titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:"CONSERVATION",trackData:t.map((t,e)=>{const n=t.frequency().filter(t=>"-"!=t.symbol).slice(0,5).map(t=>Math.trunc(100*t.value)/100),r=Math.trunc(100*t.frequency().filter(t=>"-"==t.symbol)[0].value)/100;return{begin:e+1,values:n.map((t,e)=>n.slice(0,e+1).reduce((t,e)=>t+e)).concat([1-r,1]),value:"-"!=t.frequency()[0].symbol?Math.trunc(100*t.frequency()[0].value)/100:0}})}])},processAlignmentAndFeatures(e){!function(e){var n;if(e.alignment_length&&e.alignment_length!=e.alignment_logo.length)throw"ERROR Alignment length and logo should match";null===(n=e.alignment_logo)||void 0===n||n.forEach(e=>{t.push(new f.Logo(e))})}(e.alignments)},filterFeatures:t=>(t.forEach(t=>{t.features=t.features.filter(t=>"automated matches"!=t.name)}),new Promise(e=>{e(t)}))}}},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvGroupBuilder=void 0;const o=n(12),a=n(107),i=n(113);e.RcsbFvGroupBuilder=class{static buildGroupAnnotationFv(t,e,n,i,c,s){return r(this,void 0,void 0,(function*(){return new 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0:e.alignmentFilter,page:null===(n=t.additionalConfig)||void 0===n?void 0:n.page,from:t.from,to:t.to,dynamicDisplay:!1,fitTitleWidth:!0,excludeFirstRowLink:!0,sequencePrefix:null===(r=t.additionalConfig)||void 0===r?void 0:r.sequencePrefix}),this.annotationTracks=yield this.annotationCollector.collect({group:t.group,groupId:t.groupId,sources:null===(o=t.additionalConfig)||void 0===o?void 0:o.sources,filters:null===(a=t.additionalConfig)||void 0===a?void 0:a.filters,annotationProcessing:null===(c=t.additionalConfig)||void 0===c?void 0:c.annotationProcessing,externalAnnotationTrackBuilder:null===(s=t.additionalConfig)||void 0===s?void 0:s.externalTrackBuilder}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){this.rowConfigData=this.alignmentTracks.sequence?this.alignmentTracks.sequence.concat(this.annotationTracks):this.annotationTracks}}e.RcsbFvGroupAnnotation=d},function(t,e,n){"use 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Array&&t.targetAlignmentList.sort((t,e)=>t.target_id.localeCompare(e.target_id)).forEach(a=>{if(null!=t.filterByTargetContains&&!a.target_id.includes(t.filterByTargetContains))return;if(null==a.target_sequence)return;const i=a.target_sequence,s={queryId:t.queryId,targetId:a.target_id,from:t.from,to:t.to,targetSequenceLength:i.length};r.push(a.target_id);const p=[];let d=[];const h=[];a.aligned_regions.forEach(e=>{const r=i.substring(e.target_begin-1,e.target_end);this.buildSequenceData(Object.assign(Object.assign({},s),{sequenceData:p,sequence:r,begin:e.query_begin,oriBegin:e.target_begin}));let o=!1;1!=e.target_begin&&(o=!0);let c=!1;e.target_end!=i.length&&t.querySequence&&(c=!0),n(e,s,null==t.querySequence).forEach(e=>{var 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n}(r,t.querySequence.substring(e.query_begin-1,e.query_end)).forEach(n=>{h.push(this.addAuthorResIds({begin:n+e.query_begin,oriBegin:n+e.target_begin,sourceId:a.target_id,source:t.to,provenanceName:l.RcsbAnnotationConstants.provenanceName.pdb,provenanceColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"MISMATCH",title:"MISMATCH"},s))})}),u.FeatureTools.mergeBlocks(d);const f={displayType:"sequence",displayColor:"#000000",displayData:p,dynamicDisplay:e},m={displayType:"pin",displayColor:"#FF9999",displayData:h},g={displayType:"block",displayColor:"#9999FF",displayData:d};let v=t.to?t.to.replace("_"," ")+" "+c.TagDelimiter.alignmentTitle:"";const b={trackId:"targetSequenceTrack_"+a.target_id,displayType:"composite",trackColor:"#F9F9F9",rowPrefix:v,rowTitle:this.buildAlignmentRowTitle(a,t),fitTitleWidth:t.fitTitleWidth,titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,displayConfig:[g,m,f]};o.push(b)}),{targets:r,alignments:o}}buildSequenceData(t,e){let n=t.to;!0===e&&(n=t.from);let r=l.RcsbAnnotationConstants.provenanceColorCode.external;return n!=i.Source.PdbInstance&&n!=i.Source.PdbEntity||(n=l.RcsbAnnotationConstants.provenanceName.pdb,r=l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb),t.sequence.split("").forEach((e,o)=>{const a={begin:t.begin+o,sourceId:t.targetId,source:t.to,provenanceName:n,provenanceColor:r,value:e};"string"==typeof t.targetId&&(a.sourceId=t.targetId),"number"==typeof t.oriBegin&&(a.oriBegin=t.oriBegin+o),t.sequenceData.push(this.addAuthorResIds(a,{from:t.from,to:t.to,queryId:t.queryId,targetId:t.targetId}))}),t.sequenceData}buildSequenceRowTitle(t){var e;let n;return n=t.excludeFirstRowLink||t.from!==i.SequenceReference.Uniprot?t.excludeFirstRowLink||t.from!==i.SequenceReference.PdbInstance||null==this.entityInstanceTranslator?{visibleTex:null!==(e=t.queryId)&&void 0!==e?e:t.groupId,style:{fontWeight:"bold"}}:{visibleTex:this.buildInstanceId(t.queryId),style:{fontWeight:"bold"}}:{visibleTex:t.queryId,url:s.rcsb_uniprot.url+t.queryId,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}},n}buildAlignmentRowTitle(t,e){let n;if(e.to===i.SequenceReference.PdbInstance&&null!=this.entityInstanceTranslator){const e=this.entityInstanceTranslator.translateAsymToEntity(t.target_id.split(c.TagDelimiter.instance)[1]);n={visibleTex:this.buildInstanceId(t.target_id),url:s.rcsb_entry.url+t.target_id.split(c.TagDelimiter.instance)[0]+"#entity-"+e,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}}else if(e.to!==i.SequenceReference.PdbEntity||e.excludeAlignmentLinks)if(e.to!==i.SequenceReference.PdbInstance||e.excludeAlignmentLinks||null==this.entityInstanceTranslator)n=e.to===i.SequenceReference.Uniprot?{visibleTex:t.target_id,url:s.rcsb_uniprot.url+t.target_id,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}:t.target_id;else{const e=this.entityInstanceTranslator.translateAsymToEntity(t.target_id.split(c.TagDelimiter.instance)[1]);n={visibleTex:this.buildInstanceId(t.target_id),url:s.rcsb_entry.url+t.target_id.split(c.TagDelimiter.instance)[0]+"#entity-"+e,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}}else{const e=t.target_id.split(c.TagDelimiter.entity)[1];n={visibleTex:t.target_id,url:s.rcsb_entry.url+t.target_id.split(c.TagDelimiter.entity)[0]+"#entity-"+e,style:{fontWeight:"bold",color:l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb}}}return n}addAuthorResIds(t,e){let n=t;return null!=this.entityInstanceTranslator&&this.entityInstanceTranslator.addAuthorResIds(n,e),e.to==i.SequenceReference.PdbInstance&&null!=n.sourceId&&(n.sourceId=n.sourceId.split(c.TagDelimiter.instance)[0]+c.TagDelimiter.instance+this.entityInstanceTranslator.translateAsymToAuth(n.sourceId.split(c.TagDelimiter.instance)[1])),n}buildInstanceId(t){var e;const n=t.split(c.TagDelimiter.instance)[1],r=null===(e=this.entityInstanceTranslator)||void 0===e?void 0:e.translateAsymToAuth(n);return n!==r&&r?n+"[auth "+r+"]":n}setPolymerEntityInstanceTranslator(t){this.entityInstanceTranslator=t}}},function(t,e,n){"use strict";var r=this&&this.__createBinding||(Object.create?function(t,e,n,r){void 0===r&&(r=n),Object.defineProperty(t,r,{enumerable:!0,get:function(){return e[n]}})}:function(t,e,n,r){void 0===r&&(r=n),t[r]=e[n]}),o=this&&this.__setModuleDefault||(Object.create?function(t,e){Object.defineProperty(t,"default",{enumerable:!0,value:e})}:function(t,e){t.default=e}),a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return o(e,t),e},i=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.SwissModelQueryAnnotations=void 0;const c=a(n(22));class s{static request(t){return i(this,void 0,void 0,(function*(){const e=s.url+t+s.urlSuffix;try{const t=yield fetch(e),n=yield t.json();return s.parse(n)}catch(t){throw console.error(t),t}}))}static parse(t){const e=new Array;return t.result.structures.forEach(t=>{const n={provenance_source:t.provider,type:t.method,feature_positions:[{beg_seq_id:t.from,end_seq_id:t.to}]};e.push(n)}),[{features:e}]}}e.SwissModelQueryAnnotations=s,s.url=c.swiss_model.url,s.urlSuffix=c.swiss_model.url_suffix},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.AnnotationCollectorHelper=void 0;const r=n(50),o=n(16),a=n(30);class i{static buildAnnotationTrack(t,e,n,r){let a,c;const s=n;return null!==s&&(c=s.display),a="composite"===c||"bond"===c||"pin"===c?i.buildRcsbFvRowConfigComposite(t,e,n):"area"===c||"line"===c?i.buildRcsbFvRowConfigArea(t,e,n):"block-area"===c?i.buildRcsbFvRowConfigBlockArea(t,e,n):i.buildRcsbFvRowConfigTrack(t,e,n),null!=s&&"number"==typeof s.height&&(a.trackHeight=s.height),r instanceof 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Using random config"),Object.assign(Object.assign({},n),{trackId:"annotationTrack_"+e,displayType:a,trackColor:"#F9F9F9",displayColor:c,rowTitle:s,rowPrefix:l,trackData:o})}static buildRcsbFvRowConfigArea(t,e,n){var r;const o=t.values(),a=n,c=a.display,s=a.color,l=i.buildRowTitle(a),u=a.prefix;let p=t.getRange().min,d=t.getRange().max;p>=0?p=0:Math.abs(p)>Math.abs(d)?d=-p:p=-d;const h=null!==(r=a.domain)&&void 0!==r?r:[p,d];return Object.assign(Object.assign({},n),{trackId:"annotationTrack_"+e,displayType:c,trackColor:"#F9F9F9",displayColor:s,rowTitle:l,rowPrefix:u,displayDomain:h,interpolationType:"step",trackData:o})}static buildRcsbFvRowConfigBlockArea(t,e,n){const r=t.values(),o=n,a=o.display,c=o.color,s=i.buildRowTitle(o),l=o.prefix;return Object.assign(Object.assign({},n),{trackId:"annotationTrack_"+e,displayType:a,trackColor:"#F9F9F9",displayColor:c,rowTitle:s,rowPrefix:l,displayDomain:[0,1],interpolationType:"step",trackData:r})}static buildRcsbFvRowConfigComposite(t,e,n){var o;const a=t.values();let c;const s=n;let l="block";s.display==="bond".toString()&&(l="bond",a.forEach(t=>{t.isEmpty=!0}));const u=i.buildRowTitle(s),p=s.prefix,d=null!==(o=s.color)&&void 0!==o?o:r.RcsbAnnotationConfig.randomRgba(),h=new Array,f=new Array;if(a.forEach(t=>{null!==t.end&&t.end!==t.begin?f.push(t):h.push(t)}),h.length>0&&f.length>0){const t=new Array;t.push({displayData:f,displayType:l,displayColor:d}),t.push({displayData:h,displayType:"pin",displayColor:d}),c={displayType:"composite",trackColor:"#F9F9F9",trackId:"annotationTrack_"+e,rowTitle:u,rowPrefix:p,displayConfig:t}}else h.length>0&&(l="pin");return void 0===c&&(c={trackId:"annotationTrack_"+e,displayType:l,trackColor:"#F9F9F9",displayColor:d,rowTitle:u,rowPrefix:p,trackData:a}),c}static buildRowTitle(t){return t.prefix?a.FeatureTools.parseLink(t.title):t.title}}e.AnnotationCollectorHelper=i},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.AnnotationTrackManager=void 0;const o=n(112);e.AnnotationTrackManager=class{constructor(t){this.annotationTracks=new Map,this.rcsbAnnotationConfig=t}processRcsbPdbAnnotations(t,e){var n,o,a;return r(this,void 0,void 0,(function*(){yield this.addAnnotationToTracks(e,"function"==typeof(null===(n=e.externalAnnotationTrackBuilder)||void 0===n?void 0:n.filterFeatures)?yield null===(o=e.externalAnnotationTrackBuilder)||void 0===o?void 0:o.filterFeatures(t):t),null===(a=e.annotationProcessing)||void 0===a||a.computeAnnotationValue(this.annotationTracks),this.mergeTracks()}))}getAnnotationTracks(){return this.annotationTracks}getPolymerEntityInstanceTranslator(){return this.polymerEntityInstanceTranslator}setPolymerEntityInstanceTranslator(t){this.polymerEntityInstanceTranslator=t}mergeTracks(){this.annotationTracks.forEach((t,e)=>{if(this.rcsbAnnotationConfig.isMergedType(e)){const t=this.rcsbAnnotationConfig.getMergedType(e),n=this.rcsbAnnotationConfig.getConfig(e).color;this.annotationTracks.has(t)||this.annotationTracks.set(t,new o.AnnotationTrack(e,this.rcsbAnnotationConfig.getConfig(e),this.getPolymerEntityInstanceTranslator())),this.annotationTracks.get(t).addAll(this.annotationTracks.get(e),n),this.rcsbAnnotationConfig.addMultipleProvenance(t,Array.from(this.annotationTracks.get(t).getTrackProvenance())),this.annotationTracks.delete(e)}})}buildType(t,e,n){return r(this,void 0,void 0,(function*(){return this.rcsbAnnotationConfig.buildAndAddType(n,"function"==typeof t.trackTitle?yield t.trackTitle(e,n):void 0,"function"==typeof t.titleSuffix?yield t.titleSuffix(e,n):void 0)}))}addAnnotationToTracks(t,e){return r(this,void 0,void 0,(function*(){yield Promise.all(e.map(e=>e.features.map(n=>r(this,void 0,void 0,(function*(){return yield this.addFeature(t,e,n)})))).flat())}))}addFeature(t,e,n){var a;return r(this,void 0,void 0,(function*(){if(null===(a=this.rcsbAnnotationConfig.getConfig(n.type))||void 0===a?void 0:a.ignore)return;const r=yield this.buildType(t,e,n);this.annotationTracks.has(r)||this.annotationTracks.set(r,new o.AnnotationTrack(r,this.rcsbAnnotationConfig.getConfig(r),this.getPolymerEntityInstanceTranslator())),this.rcsbAnnotationConfig.addProvenance(r,n.provenance_source),this.annotationTracks.get(r).addFeature({reference:t.reference,queryId:t.queryId,source:e.source,targetId:e.target_id,feature:n},t.annotationProcessing)}))}}},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.AnnotationTrack=void 0;const r=n(7),o=n(16),a=n(10);e.AnnotationTrack=class{constructor(t,e,n){this.valueRange={max:Number.MIN_SAFE_INTEGER,min:Number.MAX_SAFE_INTEGER},this.trackElementMap=new Map,this.entityInstanceTranslator=n,this.type=t,this.annotationConfig=e}getRange(){return this.valueRange}addFeature(t,e){(function(t){const e=new Map,n=new Array;return t.forEach(t=>{null!=t.range_id?(e.has(t.range_id)||e.set(t.range_id,new Array),e.get(t.range_id).push(t)):n.push(t)}),e.forEach((t,e)=>{if(1==t.length)n.push(t[0]);else{const e=t.sort((t,e)=>t.beg_seq_id-e.beg_seq_id),r=Object.assign(Object.assign({},e[0]),{end_seq_id:e[e.length-1].end_seq_id,end_ori_id:e[e.length-1].end_ori_id,open_end:e[e.length-1].open_end,gaps:new Array});for(let t=0;t<e.length-1;t++)r.gaps.push({begin:e[t].end_seq_id,end:e[t+1].beg_seq_id,isConnected:null==e[t].beg_ori_id||null==e[t].end_ori_id||null==e[t+1].beg_ori_id||null==e[t+1].end_ori_id||e[t].end_ori_id+1==e[t+1].beg_ori_id||e[t].end_ori_id==e[t+1].beg_ori_id+1||e[t].end_ori_id==e[t+1].beg_ori_id});n.push(r)}}),n})(t.feature.feature_positions).forEach(n=>{null!=n.beg_seq_id&&this.annotationRangeKeys(n).forEach(r=>{this.addRange(t.reference,t.queryId,t.source,t.targetId,t.feature,n,r,e)})})}size(){return this.trackElementMap.size}forEach(t){this.trackElementMap.forEach((e,n)=>{t(e,n)})}addAll(t,e){t.forEach((t,n)=>{t.color=null!=e?e:t.color,this.trackElementMap.set(n,t)})}getTrackProvenance(){return new Set(Array.from(this.trackElementMap.values()).map(t=>t.provenanceName))}set(t,e){this.trackElementMap.set(t,e)}values(){return Array.from(this.trackElementMap.values())}buildRcsbFvTrackDataElement(t,e,n,i,c){var s,l,u,p,d,h;let f=null!==(l=null===(s=this.annotationConfig)||void 0===s?void 0:s.title)&&void 0!==l?l:this.type,m=void 0;this.isNumericalDisplay(this.type)&&(m=(null===(u=this.annotationConfig)||void 0===u?void 0:u.transformToNumerical)?1:t.values instanceof Array&&null!==(p=t.values[0])&&void 0!==p?p:0),t.values instanceof Array&&t.values.length>0?(Math.max(...t.values)>this.valueRange.max&&(this.valueRange.max=Math.max(...t.values)),Math.min(...t.values)<this.valueRange.min&&(this.valueRange.min=Math.min(...t.values))):"number"==typeof m&&(m>this.valueRange.max&&(this.valueRange.max=m),m<this.valueRange.min&&(this.valueRange.min=m));let g=o.RcsbAnnotationConstants.provenanceColorCode.external;c!==o.RcsbAnnotationConstants.provenanceName.pdb&&c!==o.RcsbAnnotationConstants.provenanceName.promotif||(g=o.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb);const v=i==r.Source.PdbInstance&&null!=this.entityInstanceTranslator?n.split(a.TagDelimiter.instance)[0]+a.TagDelimiter.instance+this.entityInstanceTranslator.translateAsymToAuth(n.split(a.TagDelimiter.instance)[1]):n;return{begin:t.beg_seq_id,end:null!==(d=t.end_seq_id)&&void 0!==d?d:t.beg_seq_id,oriBegin:t.beg_ori_id,oriEnd:null!==(h=t.end_ori_id)&&void 0!==h?h:t.beg_ori_id,description:new Array,featureId:e.feature_id,type:this.type,title:f,name:e.name,value:m,gValue:e.value,gaps:t.gaps,sourceId:v,source:i,provenanceName:c,provenanceColor:g,openBegin:t.open_begin,openEnd:t.open_end}}addRange(t,e,n,r,o,a,i,c){var s,l;const u=i.join(":");if(this.trackElementMap.has(u))this.isNumericalDisplay(this.type)&&(null===(l=this.annotationConfig)||void 0===l?void 0:l.transformToNumerical)&&"number"==typeof this.trackElementMap.get(u).value&&(this.trackElementMap.get(u).value+="function"==typeof(null==c?void 0:c.getAnnotationValue)?c.getAnnotationValue({type:this.type,targetId:r,positionKey:u,d:o,p:a}):1,this.trackElementMap.get(u).value>this.valueRange.max&&(this.valueRange.max=this.trackElementMap.get(u).value),this.trackElementMap.get(u).value<this.valueRange.min&&(this.valueRange.min=this.trackElementMap.get(u).value));else{const l=this.buildRcsbFvTrackDataElement(a,o,r,n,o.provenance_source);(null===(s=this.annotationConfig)||void 0===s?void 0:s.transformToNumerical)&&this.transformToNumerical(r,i,u,l,o,a,null==c?void 0:c.getAnnotationValue),"function"==typeof(null==c?void 0:c.addTrackElementCallback)&&(null==c||c.addTrackElementCallback({type:this.type,targetId:r,positionKey:u,d:o,p:a}));const p={from:t,to:n,queryId:e,targetId:r};this.addAuthorResIds(l,p),this.trackElementMap.set(u,l),a.values instanceof Array&&this.expandValues(l,a.values,p)}"string"==typeof o.description&&this.trackElementMap.get(u).description.push(o.description)}transformToNumerical(t,e,n,r,o,a,i){"function"==typeof i&&(r.value=i({type:this.type,targetId:t,positionKey:n,d:o,p:a})),r.begin=e[0],r.end=e[0]}expandValues(t,e,n){e.forEach((e,r)=>{if(r>0){const o=(t.begin+r).toString(),a=Object.assign(Object.assign({},t),{begin:t.begin+r,end:null,oriBegin:t.oriBegin?t.oriBegin+r:null,oriEnd:null,value:e});this.addAuthorResIds(a,n),this.trackElementMap.set(o,a)}})}addAuthorResIds(t,e){let n=t;return null!=this.entityInstanceTranslator&&e.from&&this.entityInstanceTranslator.addAuthorResIds(n,e),n}isNumericalDisplay(t){return null!=this.annotationConfig&&("area"===this.annotationConfig.display||"block-area"===this.annotationConfig.display||"multi-area"===this.annotationConfig.display||"line"===this.annotationConfig.display)}annotationRangeKeys(t){var e,n,r;const o=new Array;if((null===(e=this.annotationConfig)||void 0===e?void 0:e.transformToNumerical)&&null!=t.end_seq_id)for(let e=t.beg_seq_id;e<=t.end_seq_id;e++)o.push([e]);else if(null===(n=this.annotationConfig)||void 0===n?void 0:n.transformToNumerical)o.push([t.beg_seq_id]);else{const e=null!=t.end_seq_id?[t.beg_seq_id,t.end_seq_id]:[t.beg_seq_id,t.beg_seq_id];(null===(r=this.annotationConfig)||void 0===r?void 0:r.displayCooccurrence)&&e.push(Math.ceil(1e12*Math.random())),o.push(e)}return o}}},function(t,e,n){"use strict";var r=this&&this.__createBinding||(Object.create?function(t,e,n,r){void 0===r&&(r=n),Object.defineProperty(t,r,{enumerable:!0,get:function(){return e[n]}})}:function(t,e,n,r){void 0===r&&(r=n),t[r]=e[n]}),o=this&&this.__setModuleDefault||(Object.create?function(t,e){Object.defineProperty(t,"default",{enumerable:!0,value:e})}:function(t,e){t.default=e}),a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return 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c.rcsbFvCtxManager.getEntityToInstance(a)).getData(),p=new Set;u.sort((t,e)=>parseInt(t.entityId)-parseInt(e.entityId)).forEach(t=>{p.add(t.entryId+o.TagDelimiter.entity+t.entityId)});const d=(yield c.rcsbFvCtxManager.getEntityToChromosome(Array.from(p))).getData();if(0==d.size)i.RcsbFvCoreBuilder.showMessage(t,"No genome alignments are available");else{const a=new Set;i.RcsbFvCoreBuilder.buildSelectButton(t,e,u.filter(t=>{const e=a.has(t.entryId+o.TagDelimiter.entity+t.entityId);return a.add(t.entryId+o.TagDelimiter.entity+t.entityId),d.has(t.entryId+o.TagDelimiter.entity+t.entityId)&&!e}).map((e,a)=>{const i=e.entryId+o.TagDelimiter.entity+e.entityId;return 0==a&&s.buildEntityChromosome(t,n,i).then(t=>{l(t)}),{name:e.names+" - "+e.taxIds.join(", "),label:i+" - "+e.names,shortLabel:i,onChange:()=>r(this,void 0,void 0,(function*(){yield s.buildEntityChromosome(t,n,i)}))}}),{addTitle:!0,dropdownTitle:"ENTITY"})}})))}))}static buildEntityChromosome(t,e,n){return r(this,void 0,void 0,(function*(){const o=yield s.buildChromosome(t,n,null,e,{boardConfig:{rowTitleWidth:160}}),a=yield o.getTargets();return i.RcsbFvCoreBuilder.buildSelectButton(t,e,a.map((o,a)=>({label:o,name:o,shortLabel:o,onChange:()=>r(this,void 0,void 0,(function*(){yield s.buildChromosome(t,n,o,e)}))})),{addTitle:!1,width:190,dropdownTitle:"CHROMOSOME"}),o}))}static buildChromosome(t,e,n,c,s){return r(this,void 0,void 0,(function*(){return new Promise((r,l)=>{try{i.RcsbFvCoreBuilder.createFv({elementId:t,fvModuleI:a.RcsbFvChromosome,config:{entityId:e,chrId:n,elementSelectId:c,additionalConfig:Object.assign({rcsbContext:{entryId:e.split(o.TagDelimiter.entity)[0],entityId:e.split(o.TagDelimiter.entity)[1],chrId:n}},s),resolve:r}})}catch(t){l(t)}})}))}}e.RcsbFvChromosomeBuilder=s},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))},o=this&&this.__importDefault||function(t){return t&&t.__esModule?t:{default:t}};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvChromosome=void 0;const a=n(19),i=n(14),c=n(7),s=n(37),l=n(16),u=n(127),p=n(43),d=n(128),h=n(129),f=o(n(145)),m=n(31);function g(t,e,n){return r=>{if((n?n/(r.to-r.from):1e3/(r.to-r.from))>4){const n=new Array;return e.forEach((t,e)=>{e[0]>r.to||e[1]<r.from||n.push(t)}),Promise.all(n.map(e=>(new p.RcsbQueryAlignment).request({queryId:e,from:t,to:c.SequenceReference.NcbiGenome}))).then(e=>{const r=new s.RcsbFvTrackData;return e.forEach((e,o)=>{if(null==e.query_sequence)return;const a=e.query_sequence.split("");e.target_alignment.forEach(e=>{const i=e.orientation;e.aligned_regions.forEach(e=>{const c=e.target_begin,s=e.query_begin,l=e.query_end-e.query_begin+1;for(let e=0;e<l;e++)r.push({begin:c+i*(1+3*e),value:a[s-1+e],oriBegin:s+e,source:t.toString(),sourceId:n[o]})})})}),r})}return new Promise((t,e)=>{t(null)})}}class v extends i.RcsbFvAbstractModule{constructor(){super(...arguments),this.targetAlignmentList=new Map([[c.SequenceReference.NcbiProtein,new Array],[c.SequenceReference.Uniprot,new Array],[c.SequenceReference.PdbEntity,new Array]]),this.maxRange=0,this.minRange=Number.MAX_SAFE_INTEGER,this.alignmentCollectorQueue=new u.RcsbFvAlignmentCollectorQueue(12),this.nTasks=0,this.completeTasks=0,this.batchSize=1e7,this.beginView=0,this.endView=0,this.entityBegin=0,this.entityEnd=0,this.nonExonConfigData=new Array,this.featuresConfigData=new Array,this.targetCoverages=new Map,this.chrSet=new Array,this.targetFilterFlag=!0,this.IDEOGRAM_DIV_ID="chrIdeogramDiv",this.TITLE_CHR_DIV_ID="chrTitleDiv",this.TITLE_CHR_REGION_ID="chrTitleRegion",this.currentDisplayedChrId="",this.buildSubject=new a.Subject,this.targetsSubject=new a.Subject}buildPdbGenomeFv(t,e){this.entityId=t;const n=new p.RcsbQueryAlignment;Promise.all([c.SequenceReference.NcbiProtein,c.SequenceReference.Uniprot].map(e=>n.request({queryId:t,from:c.SequenceReference.PdbEntity,to:e}))).then(n=>{n.forEach(t=>{t.target_alignment.forEach(t=>{this.targetCoverages.set(t.target_id,t.coverage)})}),this.alignmentCollectorQueue.sendTask({queryId:t,from:c.SequenceReference.PdbEntity,to:c.SequenceReference.NcbiGenome},n=>r(this,void 0,void 0,(function*(){const r=n;yield this.collectPdbWorkerResults(r,t,e)})))})}buildFullGenomeRangeFv(t){this.plotChromosomeTitle(t),this.targetFilterFlag=!1,this.genomeSequenceTracks(t),this.collectChromosomeAlignments(t,c.SequenceReference.PdbEntity),this.collectChromosomeAlignments(t,c.SequenceReference.Uniprot),this.collectChromosomeAlignments(t,c.SequenceReference.NcbiProtein)}collectPdbWorkerResults(t,e,n){return r(this,void 0,void 0,(function*(){const r=this.collectExons(t.target_alignment,"target",l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,c.SequenceReference.PdbEntity,n);this.pdbEntityTrack=this.mergeExonTracks(r,c.SequenceReference.PdbEntity)[0],this.pdbEntityTrack.displayConfig[0].displayData.forEach(t=>{t.description=[e]}),this.addSequences([this.pdbEntityTrack],c.SequenceReference.PdbEntity),this.pdbEntityTrack.rowPrefix=c.SequenceReference.PdbEntity.replace("_"," "),this.pdbEntityTrack.rowTitle={visibleTex:e,style:{fontWeight:"bold"}},this.pdbEntityTrack.hideEmptyTrackFlag=!1,yield this.buildChromosomeFv(null!=n?n:this.chrSet[0])}))}buildChromosomeFv(t){return r(this,void 0,void 0,(function*(){this.plotChromosomeTitle(t),this.genomeSequenceTracks(t),this.nonExonConfigData.push(this.pdbEntityTrack),yield this.plot(),this.collectChromosomeEntityRegion(t)}))}plotChromosomeTitle(t){var e,n;null===(e=document.getElementById(this.IDEOGRAM_DIV_ID))||void 0===e||e.remove(),null===(n=document.getElementById(this.TITLE_CHR_DIV_ID))||void 0===n||n.remove(),this.currentDisplayedChrId=t,h.NcbiSummary.requestChromosomeData(t).then(e=>{if(t==this.currentDisplayedChrId){const t=document.createElement("div");t.id=this.IDEOGRAM_DIV_ID;const n=document.createElement("div");n.style.display="inline-block",n.style.marginLeft="20px",n.id=this.TITLE_CHR_DIV_ID;const r=document.createElement("span");r.innerHTML=e.title,n.append(r);const o=document.createElement("span");o.id=this.TITLE_CHR_REGION_ID,o.innerHTML=" / Region: ["+this.entityBegin+" - "+this.entityEnd+"]",o.style.color="#666",n.append(o),document.getElementById(this.elementSelectId).insertAdjacentElement("afterend",n),document.getElementById(this.elementId).insertAdjacentElement("beforebegin",t),this.plotIdeogram(e)}})}updateChromosomeTitleRegion(){const t=document.getElementById(this.TITLE_CHR_REGION_ID);null!=t&&(t.innerHTML=" / Region: ["+this.beginView+" - "+this.endView+"]")}plotIdeogram(t){h.NcbiSummary.requestTaxonomyData(t.taxid.toString()).then(e=>{if(t.ncbiId==this.currentDisplayedChrId){const n=t.subname.includes("|")?t.subname.split("|").filter(t=>null!=t.match(/^([\dXYxy]+)$/))[0]:t.subname,r=new f.default({rotatable:!1,chrHeight:1080,chrWidth:20,organism:e.scientificname,chromosomes:[n],orientation:"horizontal",container:"#"+this.IDEOGRAM_DIV_ID,annotationHeight:8,showBandLabels:!0,annotations:[{name:this.entityId,chr:n,start:this.entityBegin,stop:this.entityEnd}],onLoad:()=>{var t,e;(null===(t=r.chromosomesArray)||void 0===t?void 0:t.length)>0?null!=document.getElementById("_ideogram")&&(document.getElementById("_ideogram").style.padding="0 0 0 0"):null===(e=document.getElementById(this.IDEOGRAM_DIV_ID))||void 0===e||e.remove()}})}})}genomeSequenceTracks(t){var e,n,r,o;this.nonExonConfigData.push({trackId:"mainSequenceTrack_5_"+t,displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",nonEmptyDisplay:!0,rowPrefix:t+" ",rowTitle:{visibleTex:"5'",style:{fontWeight:"bold"}},titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.external,updateDataOnMove:d.NcbiGenomeSequenceData.update(t,1,!1,null===(n=null===(e=this.rcsbFv)||void 0===e?void 0:e.getBoardConfig())||void 0===n?void 0:n.trackWidth)}),this.nonExonConfigData.push({trackId:"mainSequenceTrack_3_"+t,displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",rowPrefix:"",nonEmptyDisplay:!0,rowTitle:{visibleTex:"3'",style:{fontWeight:"bold"}},titleFlagColor:l.RcsbAnnotationConstants.provenanceColorCode.external,updateDataOnMove:d.NcbiGenomeSequenceData.update(t,2,!0,null===(o=null===(r=this.rcsbFv)||void 0===r?void 0:r.getBoardConfig())||void 0===o?void 0:o.trackWidth)})}collectChromosomeEntityRegion(t){const e=this.pdbEntityTrack.displayConfig[0].displayData[0].begin,n=this.pdbEntityTrack.displayConfig[0].displayData[0].end,r=[Math.max(1,e-5e6),n+5e6];this.collectChromosomeAlignments(t,c.SequenceReference.Uniprot,r,0),this.collectChromosomeAlignments(t,c.SequenceReference.NcbiProtein,r,0)}collectChromosomeAlignments(t,e,n,o){if(null!=n)this.nTasks++,this.alignmentCollectorQueue.sendTask({queryId:t,from:c.SequenceReference.NcbiGenome,to:e,range:n},t=>r(this,void 0,void 0,(function*(){const n=t;yield this.collectChromosomeWorkerResults(o,e,n,!1)})));else for(let n=0;n<30;n++)this.nTasks++,this.alignmentCollectorQueue.sendTask({queryId:t,from:c.SequenceReference.NcbiGenome,to:e,range:[n*this.batchSize,(n+1)*this.batchSize]},t=>r(this,void 0,void 0,(function*(){const r=t;yield this.collectChromosomeWorkerResults(n,e,r,!1)})))}collectChromosomeWorkerResults(t,e,n,o){return r(this,void 0,void 0,(function*(){this.completeTasks++,this.targetAlignmentList.get(e)[t]=n.target_alignment,console.log("Completed "+Math.floor(this.completeTasks/this.nTasks*100)+"%"),o?yield this.plot():this.nTasks==this.completeTasks&&(console.log("All Tasks Completed. Starting Rendering"),this.alignmentCollectorQueue.terminateWorkers(),yield this.plot())}))}collectExons(t,e,n,r,o,a){const i=new Array;return t.forEach((t,n)=>{0==t.aligned_regions.length||"query"==e&&this.targetFilterFlag&&!this.targetCoverages.has(t.target_id)||"target"==e&&null!=a&&a!=t.target_id||i.push({data:[this.normalizeTargetAlignment(t,e)],id:t.target_id})}),this.simplifyExonTracks(i.sort((t,e)=>{const n=t.data,r=e.data;return n[0].begin!=r[0].begin?n[0].begin-r[0].begin:r[0].end!=n[0].end?r[0].end-n[0].end:n[0].gaps.map(t=>t.end-t.begin).reduce((t,e)=>t+e,0)-r[0].gaps.map(t=>t.end-t.begin).reduce((t,e)=>t+e,0)}).map(t=>("target"!=e||this.chrSet.includes(t.id)||this.chrSet.push(t.id),t.data)),e,o).map((t,e)=>({trackId:"pdbTracks_"+Math.random().toString(36).substr(2),displayType:"composite",trackColor:"#F9F9F9",rowTitle:"",titleFlagColor:r,overlap:!0,displayConfig:[{displayType:"block",displayData:t,displayColor:n,selectDataInRangeFlag:!0,hideEmptyTrackFlag:!0,minRatio:2e-4}]}))}normalizeTargetAlignment(t,e){const n="query"===e?"query_begin":"target_begin",r="query"===e?"query_end":"target_end",o={begin:Math.min(t.aligned_regions[0][n],t.aligned_regions[t.aligned_regions.length-1][r]),end:Math.max(t.aligned_regions[0][n],t.aligned_regions[t.aligned_regions.length-1][r]),gaps:[],description:[t.target_id],openBegin:t.orientation<0,openEnd:t.orientation>0};return t.orientation>0?("query"==e&&t.aligned_regions[t.aligned_regions.length-1][r]>this.maxRange&&(this.maxRange=t.aligned_regions[t.aligned_regions.length-1][r]),"query"==e&&t.aligned_regions[0][n]<this.minRange&&(this.minRange=t.aligned_regions[0][n]),t.aligned_regions.forEach((e,a)=>{if(a+1<t.aligned_regions.length){const i=t.aligned_regions[a+1];let c=e[r],s=i[n];const l=e.exon_shift;1==(null==l?void 0:l.length)?(1==Math.abs(l[0]-s)||o.gaps.push({end:l[0],begin:c,isConnected:!0}),s=l[0]):2==(null==l?void 0:l.length)&&(1==Math.abs(l[1]-s)&&1==Math.abs(l[1]-l[0])?s=l[0]:1==Math.abs(l[1]-s)?(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0],s=l[1]):1==Math.abs(l[1]-l[0])?(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[1]):(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0],o.gaps.push({end:l[1],begin:c,isConnected:!0}),c=l[1])),o.gaps.push({begin:c,end:s,isConnected:!0})}})):("query"==e&&t.aligned_regions[0][n]>this.maxRange&&(this.maxRange=t.aligned_regions[0][n]),"query"==e&&t.aligned_regions[t.aligned_regions.length-1][r]<this.minRange&&(this.minRange=t.aligned_regions[t.aligned_regions.length-1][r]),t.aligned_regions.reverse().forEach((e,a)=>{if(a+1<t.aligned_regions.length){const i=t.aligned_regions[a+1];let c=e[n],s=i[r];const l=i.exon_shift;1==(null==l?void 0:l.length)?(1==Math.abs(l[0]-c)||o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0]):2==(null==l?void 0:l.length)&&(1==Math.abs(l[1]-c)&&1==Math.abs(l[1]-l[0])?c=l[0]:1==Math.abs(l[1]-c)?(c=l[1],o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0]):1==Math.abs(l[1]-l[0])?(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[1]):(o.gaps.push({end:l[0],begin:c,isConnected:!0}),c=l[0],o.gaps.push({end:l[1],begin:c,isConnected:!0}),c=l[1])),o.gaps.push({end:s,begin:c,isConnected:!0})}})),o}simplifyExonTracks(t,e,n){const r=new Array;return t.forEach(t=>{const e=t[0].begin,n=t[0].end;if(0==r.length)this.entityBegin>0&&this.entityEnd>0&&!(e>this.entityEnd||n<this.entityBegin)&&(e<this.beginView&&(this.beginView=e),n>this.endView&&(this.endView=n)),r.push(t);else{const o=r.length-1,a=r[o][0].begin,i=r[o][0].end;e+"."+t[0].gaps.map(t=>t.begin+"."+t.end).join(".")+"."+n!=a+"."+r[o][0].gaps.map(t=>t.begin+"."+t.end).join(".")+"."+i?(this.entityBegin>0&&this.entityEnd>0&&!(e>this.entityEnd||n<this.entityBegin)&&(e<this.beginView&&(this.beginView=e),n>this.endView&&(this.endView=n)),r.push(t)):r[o][0].description.push(t[0].description[0])}}),r}mergeExonTracks(t,e){const n=new Array;return t.forEach(t=>{if(0==n.length)n.push(t);else{const e=t.displayConfig[0].displayData[0].begin;let r=-1;n.forEach((t,n)=>{const o=t.displayConfig[0].displayData.length-1,a=t.displayConfig[0].displayData[o].end;e>a&&-1==r&&(r=n)}),r>=0?n[r].displayConfig[0].displayData.push(t.displayConfig[0].displayData[0]):-1==r&&n.push(t)}}),this.addSequences(n,e),n}addSequences(t,e){t.forEach(t=>{var n,r;const o=new Map;t.displayConfig[0].displayData.forEach(t=>{o.set([t.begin,t.end],t.description[0])}),t.displayConfig.push({displayType:"sequence",updateDataOnMove:g(e,o,null===(r=null===(n=this.rcsbFv)||void 0===n?void 0:n.getBoardConfig())||void 0===r?void 0:r.trackWidth),displayData:[],hideEmptyTrackFlag:!0,minRatio:.001})})}setDisplayView(){var t,e,n,o;return r(this,void 0,void 0,(function*(){if(0==this.entityBegin&&0==this.entityEnd&&(null===(e=null===(t=this.pdbEntityTrack)||void 0===t?void 0:t.displayConfig)||void 0===e?void 0:e.length)>0){const t=this.pdbEntityTrack.displayConfig[0].displayData.length-1;this.entityBegin=this.pdbEntityTrack.displayConfig[0].displayData[0].begin,this.entityEnd=this.pdbEntityTrack.displayConfig[0].displayData[t].end,this.beginView=this.pdbEntityTrack.displayConfig[0].displayData[0].begin,this.endView=this.pdbEntityTrack.displayConfig[0].displayData[t].end;const e=this.beginView,n=this.endView,r=n-e;this.boardConfigData.range={min:e-Math.ceil(.05*r),max:n+Math.ceil(.05*r)}}else if((null===(o=null===(n=this.pdbEntityTrack)||void 0===n?void 0:n.displayConfig)||void 0===o?void 0:o.length)>0){this.beginView=this.minRange,this.endView=this.maxRange;const t=this.beginView,e=this.endView,n=e-t;this.boardConfigData.range={min:t-Math.ceil(.05*n),max:e+Math.ceil(.05*n)},this.updateChromosomeTitleRegion()}yield this.display()}))}plot(){var t;return r(this,void 0,void 0,(function*(){console.log("PROCESSING");let e=new Array,n=new Array;this.targetAlignmentList.get(c.SequenceReference.NcbiProtein).forEach((t,e)=>{t.length>0&&(n=n.concat(this.collectExons(t,"query","#69b3a2","#69b3a2",c.SequenceReference.NcbiProtein)))}),n=this.mergeExonTracks(n,c.SequenceReference.NcbiProtein);let r=new Array;this.targetAlignmentList.get(c.SequenceReference.Uniprot).forEach((t,e)=>{t.length>0&&(r=r.concat(this.collectExons(t,"query","#cc99ff","#cc99ff",c.SequenceReference.Uniprot)))}),r=this.mergeExonTracks(r,c.SequenceReference.Uniprot);let o=new Array;this.targetAlignmentList.get(c.SequenceReference.PdbEntity).forEach((t,e)=>{t.length>0&&(o=o.concat(this.collectExons(t,"query",l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,l.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,c.SequenceReference.PdbEntity)))}),o=this.mergeExonTracks(o,c.SequenceReference.PdbEntity),n.length>0&&(e=e.concat(n),n[0].rowTitle="NCBI PROTEINS"),r.length>0&&(e=e.concat(r),r[0].rowTitle="UNIPROT PROTEINS"),o.length>0&&(e=e.concat(o),o[0].rowTitle="PDB ENTITIES");const a=(null===(t=this.featuresConfigData)||void 0===t?void 0:t.length)>0?this.nonExonConfigData.concat(this.featuresConfigData):this.nonExonConfigData;e.length>0?this.rowConfigData=a.concat(e):this.rowConfigData=a,console.log("RENDERING"),this.boardConfigData.hideInnerBorder=!0,this.boardConfigData.length=Math.floor(this.maxRange+.01*this.maxRange),this.boardConfigData.includeAxis=!0,yield this.setDisplayView(),this.buildSubject.next(void 0),this.targetsSubject.next(this.chrSet)}))}protectedBuild(t){return r(this,void 0,void 0,(function*(){return new Promise((e,n)=>{m.ObservableHelper.oneTimeSubscription(e,this.buildSubject),t.elementSelectId&&(this.elementSelectId=t.elementSelectId),null!=t.entityId?this.buildPdbGenomeFv(t.entityId,t.chrId):null!=t.chrId&&this.buildFullGenomeRangeFv(t.chrId)})}))}getTargets(){return r(this,void 0,void 0,(function*(){return new Promise((t,e)=>{this.chrSet.length>0?t(this.chrSet):m.ObservableHelper.oneTimeSubscription(t,this.targetsSubject)})}))}concatAlignmentAndAnnotationTracks(t){}}e.RcsbFvChromosome=v},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvAlignmentCollectorQueue=void 0;const r=n(19);e.RcsbFvAlignmentCollectorQueue=class{constructor(t){this.workerList=new Array,this.taskQueue=new Array,this.isQueueActive=!1,this.nWorkers=null!=t?t:self.navigator.hardwareConcurrency;for(let t=0;t<this.nWorkers;t++)this.workerList.push({available:!0,worker:new Worker("/saguaro/worker.js")})}sendTask(t,e){const n=this.workerList.filter(t=>t.available);n.length>0?(n[0].available=!1,n[0].worker.postMessage(t),n[0].worker.onmessage=t=>{e(t.data),n[0].available=!0}):(this.taskQueue.push({request:t,callback:e}),this.isQueueActive||this.activateQueue())}activateQueue(){this.isQueueActive=!0,this.recursiveExec()}recursiveExec(){0==this.taskQueue.length?this.isQueueActive=!1:(this.isQueueActive=!0,this.workerList.filter(t=>t.available).forEach(t=>{if(this.taskQueue.length>0){t.available=!1;const e=this.taskQueue.shift();t.worker.postMessage(e.request),t.worker.onmessage=n=>{e.callback(n.data),t.available=!0}}}),r.asyncScheduler.schedule(()=>{this.recursiveExec()},1e3))}terminateWorkers(){this.workerList.forEach(t=>{t.worker.terminate()})}}},function(t,e,n){"use strict";var r=this&&this.__createBinding||(Object.create?function(t,e,n,r){void 0===r&&(r=n),Object.defineProperty(t,r,{enumerable:!0,get:function(){return e[n]}})}:function(t,e,n,r){void 0===r&&(r=n),t[r]=e[n]}),o=this&&this.__setModuleDefault||(Object.create?function(t,e){Object.defineProperty(t,"default",{enumerable:!0,value:e})}:function(t,e){t.default=e}),a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return o(e,t),e};Object.defineProperty(e,"__esModule",{value:!0}),e.NcbiGenomeSequenceData=void 0;const i=n(19),c=a(n(22));class s{static update(t,e,n,r){let o=null;return a=>(o&&o.unsubscribe(),new Promise((c,l)=>{if((r?r/(a.to-a.from):1e3/(a.to-a.from))>4){let r=0;const u=5e3,p=()=>{const d=new XMLHttpRequest;d.timeout=u;const h=s.urlPrefix+"id="+t+"&from="+a.from+"&to="+a.to+"&strand="+e+s.urlSuffix;d.open("GET",h),d.send(),d.onloadend=t=>{const e=d.responseText.split("\n").slice(1).join("");if(e.length<1)r++,console.warn("HTTP error while access URL: "+h+" - empty sequence - "+r),r<4?o=i.asyncScheduler.schedule(()=>{p()},u):l("HTTP error while access URL: "+h+" - No more attempts after "+r);else{const t=[{begin:a.from,value:n?e.split("").reverse().join(""):e}];c(t)}},d.onerror=t=>{r++,console.warn("HTTP error while access URL: "+h+" - "+r),r<4?o=i.asyncScheduler.schedule(()=>{p()},u):l("HTTP error while access URL: "+h+" - No more attempts after "+r)}};p()}else c(null)}))}}e.NcbiGenomeSequenceData=s,s.urlPrefix=c.ncbi_genome_sequence.url,s.urlSuffix=c.ncbi_genome_sequence.url_suffix},function(t,e,n){"use strict";var r=this&&this.__createBinding||(Object.create?function(t,e,n,r){void 0===r&&(r=n),Object.defineProperty(t,r,{enumerable:!0,get:function(){return e[n]}})}:function(t,e,n,r){void 0===r&&(r=n),t[r]=e[n]}),o=this&&this.__setModuleDefault||(Object.create?function(t,e){Object.defineProperty(t,"default",{enumerable:!0,value:e})}:function(t,e){t.default=e}),a=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)"default"!==n&&Object.hasOwnProperty.call(t,n)&&r(e,t,n);return o(e,t),e};Object.defineProperty(e,"__esModule",{value:!0}),e.NcbiSummary=void 0;const i=n(19),c=a(n(22));class s{static requestChromosomeData(t){s.jobTask&&s.jobTask.unsubscribe();const e=c.ncbi_summary_nuccore.url,n=c.ncbi_summary_nuccore.url_suffix;return new Promise((r,o)=>{const a=()=>{const o=e+t+n,c=new XMLHttpRequest;c.timeout=s.httpTimeout,c.open("GET",o),c.send(),c.onloadend=e=>{var n,o;if(0==c.responseText.length)s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout);else{const e=JSON.parse(c.responseText),a=null===(o=null===(n=e)||void 0===n?void 0:n.result)||void 0===o?void 0:o.uids[0],i=e.result[a];i.ncbiId=t,r(i)}},c.onerror=t=>{s.jobTask&&s.jobTask.unsubscribe(),s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout)}};a()})}static requestTaxonomyData(t){s.jobTask&&s.jobTask.unsubscribe();const e=c.ncbi_summary_taxonomy.url,n=c.ncbi_summary_taxonomy.url_suffix;return new Promise((r,o)=>{const a=()=>{const o=e+t+n,c=new XMLHttpRequest;c.timeout=s.httpTimeout,c.open("GET",o),c.send(),c.onloadend=t=>{var e,n;if(0==c.responseText.length)s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout);else{const t=JSON.parse(c.responseText),o=null===(n=null===(e=t)||void 0===e?void 0:e.result)||void 0===n?void 0:n.uids[0];r(t.result[o])}},c.onerror=t=>{s.jobTask=i.asyncScheduler.schedule(()=>{a()},s.timeout)}};a()})}}e.NcbiSummary=s,s.timeout=3e3,s.httpTimeout=1e4,s.jobTask=null},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvPairwiseAligmentBuilder=void 0;const o=n(12),a=n(131);e.RcsbFvPairwiseAligmentBuilder=class{static buildPairwiseAlignment(t,e,n){return r(this,void 0,void 0,(function*(){return new Promise((r,i)=>{try{o.RcsbFvCoreBuilder.createFv({elementId:t,fvModuleI:a.RcsbFvPairwiseAlignment,config:{psa:e,additionalConfig:Object.assign({rcsbContext:{queryId:e.queryId,targetId:e.targetId}},n),resolve:r}})}catch(t){i(t)}})}))}}},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvPairwiseAlignment=void 0;const o=n(14),a=n(132);class i extends o.RcsbFvAbstractModule{protectedBuild(t){var e;return r(this,void 0,void 0,(function*(){const n=new a.PairwiseAlignmentBuilder(t.psa),r=Object.assign({rowTitleWidth:120,trackWidth:800,length:n.getLength(),includeAxis:!t.psa.pairwiseView},null===(e=t.additionalConfig)||void 0===e?void 0:e.boardConfig);this.boardConfigData=Object.assign(Object.assign({},this.boardConfigData),r),this.rowConfigData=t.psa.pairwiseView?n.buildPairwiseAlignment():n.buildReferenceAlignment()}))}concatAlignmentAndAnnotationTracks(t){}}e.RcsbFvPairwiseAlignment=i},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.PairwiseAlignmentBuilder=void 0;const r=n(16),o=n(7),a=n(30),i=(t,e,n)=>{const r=n,o=1-r;return[Math.round(t[0]*r+e[0]*o),Math.round(t[1]*r+e[1]*o),Math.round(t[2]*r+e[2]*o)]};e.PairwiseAlignmentBuilder=class{constructor(t){if(this.querySequence=t.querySequence,this.targetSequence=t.targetSequence,this.queryAlignment=t.queryAlignment,this.targetAlignment=t.targetAlignment,this.queryBegin=t.queryBegin,this.queryEnd=t.queryEnd,this.targetBegin=t.targetBegin,this.targetEnd=t.targetEnd,this.targetId=t.targetId,this.queryId=t.queryId,this.sequenceId=t.sequenceId,this.isQueryExternal=t.isQueryExternal,this.isTargetExternal=t.isTargetExternal,this.pairwiseView=t.pairwiseView,this.queryAlignment.length!=this.targetAlignment.length)throw"Sequence alignments length mismatch";this.pairwiseView?this.alignmentLength=this.queryAlignment.length:this.alignmentLength=this.querySequence.length}getLength(){return this.alignmentLength}buildReferenceAlignment(){const t=this.queryAlignment.split(""),e=this.targetAlignment.split(""),n=[],a=[],c=[];let s=this.queryBegin,l=this.targetBegin,u=this.queryBegin,p=this.targetBegin;t.forEach((t,i)=>{const d=e[i];("-"===d||"-"===t)&&u>0&&(n.push({begin:u,end:s-1,oriBegin:p,oriEnd:l-1,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"}),u=0),"-"!=t&&"-"!=d&&(c.push({begin:s,oriBegin:l,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,value:d,type:"RESIDUE",title:"RESIDUE"}),t!=d&&a.push({begin:s,oriBegin:l,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"MISMATCH",title:"MISMATCH"})),"-"!=d&&"-"!=t&&0==u&&(u=s,p=l),"-"!=t&&s++,"-"!=d&&l++}),u>0&&n.push({begin:u,end:s-1,oriBegin:p,oriEnd:l-1,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"}),this.addBlockTerminalTags(n);const d={trackId:"query_sequence",displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",titleFlagColor:this.isQueryExternal?r.RcsbAnnotationConstants.provenanceColorCode.external:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,rowTitle:this.queryId,nonEmptyDisplay:!0,trackData:[{value:this.querySequence,begin:1}]},h={displayType:"sequence",displayColor:"#333333",displayData:c},f={displayType:"pin",displayColor:"#FF9999",displayData:a,minRatio:5},m={displayType:"block",displayColor:"rgb("+i([153,153,255],[50,50,50],this.sequenceId).join(",")+")",displayData:n};return[d,{trackId:"targetSequenceTrack",rowTitle:this.targetId,displayType:"composite",trackColor:"#F9F9F9",titleFlagColor:this.isTargetExternal?r.RcsbAnnotationConstants.provenanceColorCode.external:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,displayConfig:[m,f,h]}]}buildPairwiseAlignment(){const t=this.queryAlignment.split(""),e=this.targetAlignment.split(""),n=[],a=[],c=[],s=[];let l=this.queryBegin,u=this.targetBegin,p=1;t.forEach((t,i)=>{const d=e[i];"-"===t||"-"===d?p>0&&i>p&&(n.push({begin:p,end:i,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"}),p=0):"-"!=t&&"-"!=d&&0==p&&(p=i+1),"-"!=t&&"-"!=d&&t!=d&&p>0&&a.push({begin:i+1,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"MISMATCH",title:"MISMATCH"}),c.push({begin:i+1,value:t,source:r.RcsbAnnotationConstants.provenanceName.userInput,sourceId:"QUERY SEQUENCE",provenanceName:r.RcsbAnnotationConstants.provenanceName.userInput,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.external,oriBegin:"-"!=t?l:void 0}),"-"!=t&&l++,s.push({begin:i+1,value:d,source:o.SequenceReference.PdbEntity,sourceId:this.targetId,provenanceName:o.SequenceReference.PdbEntity,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,oriBegin:"-"!=d?u:void 0}),"-"!=d&&u++}),p>0&&n.push({begin:p,end:this.alignmentLength,provenanceName:r.RcsbAnnotationConstants.provenanceName.mmseqs,provenanceColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,type:"ALIGNED_BLOCK",title:"ALIGNED REGION"});const d={trackId:"query_sequence",displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",rowTitle:"QUERY",nonEmptyDisplay:!0,trackData:c},h={trackId:"target_sequence",displayType:"sequence",trackColor:"#F9F9F9",displayColor:"#000000",rowTitle:this.targetId,nonEmptyDisplay:!0,trackData:s},f={displayType:"pin",displayColor:"#FF9999",displayData:a,minRatio:5},m={displayType:"block",displayColor:"rgb("+i([153,153,255],[50,50,50],this.sequenceId).join(",")+")",displayData:n};return[d,{trackId:"targetSequenceTrack",displayType:"composite",trackColor:"#F9F9F9",titleFlagColor:r.RcsbAnnotationConstants.provenanceColorCode.rcsbPdb,displayConfig:[m,f]},h]}addBlockTerminalTags(t){t[0].oriBegin>1&&(t[0].openBegin=!0);for(let e=0;e<t.length-1;e++)t[e].oriEnd+1!=t[e+1].oriBegin&&(t[e].openEnd=!0,t[e+1].openBegin=!0);t[t.length-1].oriEnd<this.targetSequence.length&&(t[t.length-1].openEnd=!0),a.FeatureTools.mergeBlocks(t)}}},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvUniprotEntity=void 0;const o=n(7),a=n(14),i=n(10);class c extends a.RcsbFvAbstractModule{protectedBuild(t){return r(this,void 0,void 0,(function*(){const e=t.upAcc,n=t.entityId,r=t.additionalConfig,a=[{field:o.FieldName.TargetId,operation:o.OperationType.Equals,source:o.Source.PdbEntity,values:[n]}];this.alignmentTracks=yield this.sequenceCollector.collect({queryId:e,from:o.SequenceReference.Uniprot,to:o.SequenceReference.PdbEntity,filterByTargetContains:n,excludeAlignmentLinks:!0}),this.annotationTracks=yield this.annotationCollector.collect({queryId:e,reference:o.SequenceReference.Uniprot,sources:(null==r?void 0:r.sources)?r.sources:[o.Source.PdbEntity,o.Source.Uniprot],filters:(null==r?void 0:r.filters)instanceof Array?r.filters.concat(a):a,titleSuffix:this.titleSuffix.bind(this)}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){this.rowConfigData=this.alignmentTracks.sequence.concat(this.alignmentTracks.alignment).concat(this.annotationTracks)}titleSuffix(t,e){return r(this,void 0,void 0,(function*(){let e=t.target_id;if(null!=this.polymerEntityInstance&&t.source===o.Source.PdbInstance){const n=t.target_id.split(i.TagDelimiter.instance)[1],r=this.polymerEntityInstance.translateAsymToAuth(n);e=n===r?n:n+"[auth "+r+"]"}return e}))}}e.RcsbFvUniprotEntity=c},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvUniprotInstance=void 0;const o=n(7),a=n(14);class i extends a.RcsbFvAbstractModule{protectedBuild(t){return r(this,void 0,void 0,(function*(){const e=t.upAcc,n=t.entityId,r=t.instanceId,a=t.additionalConfig;let i=[o.Source.Uniprot,o.Source.PdbEntity,o.Source.PdbInstance];null!=a&&null!=a.sources&&a.sources.length>0&&(i=a.sources);let c=[{field:o.FieldName.TargetId,operation:o.OperationType.Equals,source:o.Source.PdbEntity,values:[n]},{field:o.FieldName.TargetId,operation:o.OperationType.Contains,source:o.Source.PdbInstance,values:[r]}];null!=a&&null!=a.filters&&a.filters.length>0&&(c=a.filters),this.alignmentTracks=yield this.sequenceCollector.collect({queryId:e,from:o.SequenceReference.Uniprot,to:o.SequenceReference.PdbInstance,filterByTargetContains:r,excludeFirstRowLink:!0}),this.annotationTracks=yield this.annotationCollector.collect({queryId:e,reference:o.SequenceReference.Uniprot,sources:i,filters:c,collectSwissModel:!0}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){this.rowConfigData=this.alignmentTracks.sequence.concat(this.alignmentTracks.alignment).concat(this.annotationTracks)}}e.RcsbFvUniprotInstance=i},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvUniprot=void 0;const o=n(7),a=n(14),i=n(136);class c extends a.RcsbFvAbstractModule{constructor(t,e){super(t,e),this.sequenceCollector=new i.ObservedSequenceCollector}protectedBuild(t){return r(this,void 0,void 0,(function*(){const e=t.upAcc,n=[o.Source.Uniprot];this.alignmentTracks=yield this.sequenceCollector.collect({queryId:e,from:o.SequenceReference.Uniprot,to:o.SequenceReference.PdbEntity,dynamicDisplay:!1,fitTitleWidth:!0,excludeFirstRowLink:!0}),this.annotationTracks=yield this.annotationCollector.collect({queryId:e,reference:o.SequenceReference.Uniprot,sources:n,collectSwissModel:!0}),this.boardConfigData.length=this.sequenceCollector.getSequenceLength(),this.boardConfigData.includeAxis=!0}))}concatAlignmentAndAnnotationTracks(t){var e;this.rowConfigData=(null===(e=t.additionalConfig)||void 0===e?void 0:e.hideAlignments)?this.alignmentTracks.sequence.concat(this.annotationTracks):this.alignmentTracks.sequence.concat(this.annotationTracks).concat(this.alignmentTracks.alignment)}}e.RcsbFvUniprot=c},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.ObservedSequenceCollector=void 0;const o=n(7),a=n(24),i=n(137),c=n(45),s=n(10),l=n(13),u=n(29);e.ObservedSequenceCollector=class{constructor(){this.entityInstanceMap=new i.MultipleEntityInstanceTranslate,this.unObservedMap=new Map,this.sequenceCollector=new a.SequenceCollector,this.rcsbFvQuery=new l.RcsbClient}collect(t,e){return r(this,void 0,void 0,(function*(){const n=yield this.collectUnmodeledRegions(t);return this.loadObservedRegions(n),yield this.sequenceCollector.collect(t,e,this.collectEntityInstanceMap.bind(this),this.tagObservedRegions.bind(this))}))}getTargets(){return this.sequenceCollector.getTargets()}getAlignmentResponse(){return this.sequenceCollector.getAlignmentResponse()}getSequenceLength(){return this.sequenceCollector.getSequenceLength()}getPolymerEntityInstanceTranslator(){return this.polymerEntityInstanceTranslator}setPolymerEntityInstanceTranslator(t){this.sequenceCollector.setPolymerEntityInstanceTranslator(t),this.polymerEntityInstanceTranslator=t}setExternalTrackBuilder(t){this.sequenceCollector.setExternalTrackBuilder(t),this.externalTrackBuilder=t}loadObservedRegions(t){t.forEach(t=>{t.features.forEach(e=>{e.feature_positions.forEach(e=>{this.addUnmodelled(t.target_id,e.beg_seq_id,e.end_seq_id)})})})}addUnmodelled(t,e,n,r){this.unObservedMap.has(t)||this.unObservedMap.set(t,new Set),Array(n-e+1).fill(0).map((t,n)=>e+n).forEach(e=>{r&&this.unObservedMap.get(t).has(e)?this.unObservedMap.get(t).delete(e):this.unObservedMap.get(t).add(e)})}collectUnmodeledRegions(t){const e=[{field:o.FieldName.Type,operation:o.OperationType.Equals,source:o.Source.PdbInstance,values:[o.Type.UnobservedResidueXyz]}],n=[o.Source.PdbInstance];return t.group?this.rcsbFvQuery.requestRcsbPdbGroupAnnotations({groupId:t.groupId,group:t.group,sources:n,filters:e}):this.rcsbFvQuery.requestRcsbPdbAnnotations({queryId:t.queryId,reference:t.from,sources:n,filters:e})}tagObservedRegions(t,e,n){if(null!=this.entityInstanceMap.getEntity(e.targetId)){const r=this.entityInstanceMap.getEntity(e.targetId).translateEntityToAsym(e.targetId.split(s.TagDelimiter.entity)[1]),o=e.targetId.split(s.TagDelimiter.entity)[0],a=new Map;r.forEach(e=>{this.unObservedMap.has(o+s.TagDelimiter.instance+e)&&this.unObservedMap.get(o+s.TagDelimiter.instance+e).forEach(e=>{e>=t.query_begin&&e<=t.query_end&&(a.has(e)?a.set(e,a.get(e)+1):a.set(e,1))})});const i=Array.from(a.entries()).filter(t=>t[1]==r.length).map(t=>t[0]).sort((t,e)=>t-e);if(i.length>0){let r=i.shift(),o=r,a=t.target_begin-t.query_begin;const c=new Array;0==i.length&&c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0}),i.forEach((t,e)=>{t==o+1?o=t:(c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0}),r=t,o=t,e==i.length-1&&c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0}))}),o>r&&c.push({query_begin:r,query_end:o,target_begin:r+a,target_end:o+a,unModelled:!0});const s=new Array;t.query_begin<c[0].query_begin&&s.push({query_begin:t.query_begin,query_end:c[0].query_begin-1,target_begin:t.target_begin,target_end:c[0].target_begin-1,openBegin:!1,openEnd:!1,unModelled:!1}),s.push(Object.assign(Object.assign({},c.shift()),{openBegin:!1,openEnd:!1})),c.forEach((t,e)=>{const n=s.length-1;s.push({query_begin:s[n].query_end+1,query_end:t.query_begin-1,target_begin:s[n].target_end+1,target_end:t.target_begin-1,openBegin:!1,openEnd:!1,unModelled:!1}),s.push(Object.assign(Object.assign({},t),{openBegin:!1,openEnd:!1}))});const l=s.length-1;return s[l].query_end<t.query_end&&s.push({query_begin:s[l].query_end+1,query_end:t.query_end,target_begin:s[l].target_end+1,target_end:t.target_end,openBegin:!1,openEnd:!1,unModelled:!1}),s[0].openBegin=1!=s[0].target_begin,s[s.length-1].openEnd=s[s.length-1].target_end!=e.targetSequenceLength&&!n,s}}return[Object.assign(Object.assign({},t),{unModelled:!1})]}collectEntityInstanceMap(t){return r(this,void 0,void 0,(function*(){const e=new c.MultipleEntityInstancesCollector;(yield Promise.all(u.Operator.arrayChunk(t,100).map(t=>e.collect({entity_ids:t})))).forEach(t=>{this.entityInstanceMap.add(t)})}))}}},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MultipleEntityInstanceTranslate=void 0;const r=n(38),o=n(10),a=n(29);e.MultipleEntityInstanceTranslate=class{constructor(){this.entityInstanceTranslateMap=new Map}add(t){const e=new Map;t.forEach(t=>{const n=t.entryId+o.TagDelimiter.entity+t.entityId;e.has(n)||e.set(n,new 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o=n(10),a=n(139),i=n(7),c=n(12),s=n(55);class l{static buildEntitySummaryFv(t,e,n){return r(this,void 0,void 0,(function*(){return new Promise((p,d)=>{const h=n.split(o.TagDelimiter.entity)[0],f=n.split(o.TagDelimiter.entity)[0];c.RcsbFvCoreBuilder.getPolymerEntityInstanceMapAndCustomBuildFv(f,d=>r(this,void 0,void 0,(function*(){const f=yield c.RcsbFvCoreBuilder.createFv({elementId:t,fvModuleI:a.RcsbFvEntity,p:d,config:{entityId:n,elementSelectId:e,additionalConfig:Object.assign({rcsbContext:{entryId:n.split(o.TagDelimiter.entity)[0],entityId:n.split(o.TagDelimiter.entity)[1]}},u()),resolve:p}}),m=yield f.getTargets();return c.RcsbFvCoreBuilder.buildSelectButton(t,e,[n].concat(m).map(e=>({label:e,onChange:()=>r(this,void 0,void 0,(function*(){e===n?yield l.buildSingleEntitySummaryFv(t,n):yield s.RcsbFvUniprotBuilder.buildUniprotEntityFv(t,e,n,u({field:i.FieldName.TargetId,operation:i.OperationType.Contains,source:i.Source.PdbInstance,values:[h]}))}))}))),f})))})}))}static buildSingleEntitySummaryFv(t,e){return r(this,void 0,void 0,(function*(){return new Promise((n,r)=>{const i=e.split(o.TagDelimiter.entity)[0];c.RcsbFvCoreBuilder.getPolymerEntityInstanceMapAndBuildFv(t,i,a.RcsbFvEntity,{entityId:e,additionalConfig:Object.assign({rcsbContext:{entryId:e.split(o.TagDelimiter.entity)[0],entityId:e.split(o.TagDelimiter.entity)[1]}},u()),resolve:n})})}))}static buildEntityFv(t,e,n){return r(this,void 0,void 0,(function*(){return new Promise((r,i)=>{const s=e.split(o.TagDelimiter.entity)[0];c.RcsbFvCoreBuilder.getPolymerEntityInstanceMapAndBuildFv(t,s,a.RcsbFvEntity,{entityId:e,additionalConfig:Object.assign({rcsbContext:{entryId:e.split(o.TagDelimiter.entity)[0],entityId:e.split(o.TagDelimiter.entity)[1]}},n),resolve:r})})}))}}function u(t){const e=[{field:i.FieldName.Type,operation:i.OperationType.Equals,source:i.Source.PdbInstance,values:[i.Type.UnobservedResidueXyz,i.Type.UnobservedAtomXyz]}];return t&&e.push(t),{sources:[i.Source.PdbEntity,i.Source.PdbInstance],filters:e}}e.RcsbFvEntityBuilder=l},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvEntity=void 0;const o=n(7),a=n(14),i=n(10);class c extends a.RcsbFvAbstractModule{protectedBuild(t){var e,n;return r(this,void 0,void 0,(function*(){const r=t.entityId,a=(null===(e=t.additionalConfig)||void 0===e?void 0:e.filters)?t.additionalConfig.sources:[o.Source.PdbEntity,o.Source.Uniprot];this.alignmentTracks=yield this.sequenceCollector.collect({queryId:r,from:o.SequenceReference.PdbEntity,to:o.SequenceReference.Uniprot}),this.annotationTracks=yield 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0:e.hideAlignments)?this.alignmentTracks.sequence.concat(this.annotationTracks):this.alignmentTracks.sequence.concat(this.alignmentTracks.alignment).concat(this.annotationTracks)}}e.RcsbFvInstance=i},function(t,e,n){"use strict";var r=this&&this.__awaiter||function(t,e,n,r){return new(n||(n=Promise))((function(o,a){function i(t){try{s(r.next(t))}catch(t){a(t)}}function c(t){try{s(r.throw(t))}catch(t){a(t)}}function s(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(i,c)}s((r=r.apply(t,e||[])).next())}))};Object.defineProperty(e,"__esModule",{value:!0}),e.RcsbFvProteinSequenceBuilder=void 0;const o=n(7),a=n(142),i=n(12);e.RcsbFvProteinSequenceBuilder=class{static buildPfv(t,e){var n;return r(this,void 0,void 0,(function*(){const r=null!==(n=e.alignmentSource)&&void 0!==n?n:e.reference,c=[o.Source.Uniprot];return 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sapiens",assemblies:{default:"GCF_000001405.26",GRCh38:"GCF_000001405.26",GRCh37:"GCF_000001405.13",NCBI36:"GCF_000001405.12"}},10090:{commonName:"Mouse",scientificName:"Mus musculus",assemblies:{default:"GCF_000001635.20",GRCm38:"GCF_000001635.20",MGSCv37:"GCF_000001635.18"}},9598:{commonName:"Chimpanzee",scientificName:"Pan troglodytes",assemblies:{default:"GCF_000001515.7","Pan_tro 3.0":"GCF_000001515.7"}},10116:{commonName:"Rat",scientificName:"Rattus norvegicus",assemblies:{default:"GCF_000001895.5","Rnor_6.0":"GCF_000001895.5"}},3702:{commonName:"Thale cress",scientificName:"Arabidopsis thaliana",assemblies:{default:"GCF_000001735.3",TAIR10:"GCF_000001735.3"}},4530:{commonName:"Rice",scientificName:"Oryza sativa",assemblies:{default:"GCA_001433935.1","IRGSP-1.0":"GCA_001433935.1"}},4577:{commonName:"Maize",scientificName:"Zea mays",assemblies:{default:"GCA_000005005.5","IRGSP-1.0":"GCA_001433935.1"}},4641:{commonName:"Banana",scientificName:"Musa acuminata",assemblies:{default:"mock"}},7227:{commonName:"Fly",scientificName:"Drosophila melanogaster",assemblies:{default:"GCA_000001215.4","Release 6 plus ISO1 MT":"GCA_000001215.4"}},7165:{commonName:"Mosquito",scientificName:"Anopheles gambiae",assemblies:{default:""}},746128:{commonName:"Aspergillis fumigatus",scientificName:"Aspergillis fumigatus",assemblies:{default:""}},227321:{commonName:"Aspergillus nidulans",scientificName:"",assemblies:{default:""}},5061:{commonName:"black mold",scientificName:"Aspergillus niger",assemblies:{default:""}},5062:{commonName:"koji",scientificName:"Aspergillus oryzae",assemblies:{default:""}},15368:{commonName:"",scientificName:"Brachypodium distachyon",assemblies:{default:""}},60711:{commonName:"",scientificName:"Chlorocebus sabaeus",assemblies:{default:""}},7719:{commonName:"Vase tunicate",scientificName:"Ciona intestinalis",assemblies:{default:""}},9685:{commonName:"Cat",scientificName:"Felis catus",assemblies:{default:""}},9031:{commonName:"Chicken",scientificName:"Gallus gallus",assemblies:{default:""}},9593:{commonName:"Gorilla",scientificName:"Gorilla gorilla",assemblies:{default:""}},4513:{commonName:"Barley",scientificName:"Hordeum vulgare",assemblies:{default:""}},9541:{commonName:"Crab-eating macaque",scientificName:"Macaca fascicularis",assemblies:{default:""}},9544:{commonName:"Rhesus macaque",scientificName:"Macaca mulatta",assemblies:{default:""}},9597:{commonName:"Bonobo",scientificName:"Pan paniscus",assemblies:{default:""}},9615:{commonName:"Dog",scientificName:"Canis lupus familiaris",assemblies:{default:""}},4932:{commonName:"Yeast",scientificName:"Saccharomyces cerevisiae",assemblies:{default:"GCA_000146045.2",R64:"GCA_000146045.2"}},5833:{commonName:"malaria parasite",scientificName:"Plasmodium falciparum",assemblies:{default:"GCA_000002765.3",GCA_000002765:"GCA_000002765.3"}},6239:{commonName:"worm",scientificName:"Caenorhabditis elegans",assemblies:{default:"GCF_000002985.6",GCA_000002765:"GCF_000002985.6"}}};Qo=[["gneg","#FFF","#FFF","#DDD"],["gpos25","#C8C8C8","#DDD","#BBB"],["gpos33","#BBB","#BBB","#AAA"],["gpos50","#999","#AAA","#888"],["gpos66","#888","#888","#666"],["gpos75","#777","#777","#444"],["gpos100","#444","#666","#000"],["acen","#FEE","#FEE","#FDD"],["noBands","#BBB","#BBB","#AAA"]];let Ko='#_ideogram {padding-left: 5px;} #_ideogram .labeled {padding-left: 15px;} #_ideogram.labeledLeft {padding-left: 15px; padding-top: 15px;} #_ideogram text {font: 9px Tahoma; fill: #000;} #_ideogram .italic {font-style: italic;} #_ideogram .chromosome {cursor: pointer; fill: #AAA;}#_ideogram.no-rotate .chromosome {cursor: default;} #_ideogram .chrLabel, #_ideogram .annot {cursor: pointer;}#_ideogram .chrSetLabel {font-weight: bolder;}#_ideogram .ghost {opacity: 0.2;}#_ideogram .hidden {display: none;}#_ideogram .bandLabelStalk line {stroke: #AAA; stroke-width: 1;}#_ideogram .syntenyBorder 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#EEF}#_ideogram .gneg {fill: url("#gneg")} #_ideogram .gpos25 {fill: url("#gpos25")} #_ideogram .gpos33 {fill: url("#gpos33")} #_ideogram .gpos50 {fill: url("#gpos50")} #_ideogram .gpos66 {fill: url("#gpos66")} #_ideogram .gpos75 {fill: url("#gpos75")} #_ideogram .gpos100 {fill: url("#gpos100")} #_ideogram .gpos {fill: url("#gpos100")} #_ideogram .acen {fill: url("#acen")} #_ideogram .stalk {fill: url("#stalk")} #_ideogram .gvar {fill: url("#gvar")} #_ideogram .noBands {fill: url("#noBands")} #_ideogram .chromosome {fill: url("#noBands")} ';function $o(t){var e;this.config=JSON.parse(JSON.stringify(t)),(e=this).chromosomesArray=[],e.coordinateSystem="iscn",e.maxLength={bp:0,iscn:0},e.chromosomes={},e.numChromosomes=0,e.config.debug||(e.config.debug=!1),e.config.dataDir||(e.config.dataDir=e.getDataDir()),e.config.container||(e.config.container="body"),e.selector=e.config.container+" #_ideogram",e.config.resolution||(e.config.resolution=""),e.config.orientation||(e.config.orientation="vertical"),e.config.brush||(e.config.brush=null),e.config.rows||(e.config.rows=1),"showChromosomeLabels"in e.config==0&&(e.config.showChromosomeLabels=!0),e.config.showNonNuclearChromosomes||(e.config.showNonNuclearChromosomes=!1),e.config.chromosomeScale||(e.config.chromosomeScale="absolute"),e.config.showTools||(e.config.showTools=!1),function(t){t.config.ploidy||(t.config.ploidy=1),t.config.ploidy>1&&(t.sexChromosomes={},t.config.sex||(t.config.sex="male"),2!==t.config.ploidy||t.config.ancestors||(t.config.ancestors={M:"#ffb6c1",P:"#add8e6"},t.config.ploidyDesc="MP"))}(this),function(t){t.config.showBandLabels||(t.config.showBandLabels=!1),"showFullyBanded"in t.config==!1&&(t.config.showFullyBanded=!0),t.bandsToShow=[],t.bandData={}}(this),function(t){var e,n,r;t.config.chrHeight||(e=t.config.container,n=document.querySelector(e).getBoundingClientRect(),r="vertical"===t.config.orientation?n.height:n.width,"body"!==e&&0!==r||(r=400),t.config.chrHeight=r)}(this),function(t){var e,n;t.config.chrWidth||(e=10,(n=t.config.chrHeight)<900&&n>500?e=Math.round(n/40):n>=900&&(e=Math.round(n/45)),t.config.chrWidth=e)}(this),function(t){t.config.geometry&&"collinear"===t.config.geometry?"chrMargin"in t.config==!1&&(t.config.chrMargin=0):(t.config.chrMargin||(1===t.config.ploidy?t.config.chrMargin=10:t.config.chrMargin=Math.round(t.config.chrWidth/4)),t.config.showBandLabels&&(t.config.chrMargin+=20))}(this),function(t,e){t.onLoad&&(e.onLoadCallback=t.onLoad),t.onLoadAnnots&&(e.onLoadAnnotsCallback=t.onLoadAnnots),t.onDrawAnnots&&(e.onDrawAnnotsCallback=t.onDrawAnnots),t.onBrushMove&&(e.onBrushMoveCallback=t.onBrushMove),t.onCursorMove&&(e.onCursorMoveCallback=t.onCursorMove),t.onDidRotate&&(e.onDidRotateCallback=t.onDidRotate),t.onWillShowAnnotTooltip&&(e.onWillShowAnnotTooltipCallback=t.onWillShowAnnotTooltip),t.onClickAnnot&&(e.onClickAnnotCallback=t.onClickAnnot)}(t,this),function(t){t.organisms=Object.assign({},Yo),t.organismsWithBands=Object.assign({},t.organisms)}(this),function(t){t.bump=Math.round(t.config.chrHeight/125),t.adjustedBump=!1,t.config.chrHeight<200&&(t.adjustedBump=!0,t.bump=4)}(this),function(t,e){t.chromosome&&(e.config.chromosomes=[t.chromosome],"showBandLabels"in t==!1&&(e.config.showBandLabels=!0),"rotatable"in t==!1&&(e.config.rotatable=!1))}(t,this),function(t){const e=t.config;e.chrLabelSize||(t.config.chrLabelSize=9),e.chrLabelColor||(t.config.chrLabelColor="#000");const n=`font-size: ${e.chrLabelSize}px`,r=`fill: ${e.chrLabelColor}`;Ko+=`#_ideogram text {${n}; ${r};}`}(this),this.initAnnotSettings(),this.config.geometry&&"parallel"!==this.config.geometry||(this.config.chrMargin+=this.config.chrWidth,"heatmap"===this.config.annotationsLayout?this.config.chrMargin+=this.config.annotTracksHeight:this.config.chrMargin+=2*this.config.annotTracksHeight),this.init()}function Xo(t,e,n,r){var o,a,i,c,s,l,u,p=r.config,d=p.chrLabelSize;for(o=0;o<t.length;o++){if(a=t[o],i=e[o]+23-d,l=r.chromosomesArray[o].id.split("-")[1],s=n-200*(u=r.config.taxids.indexOf(l))-30,0===u?(c=-34,s+=2*r.config.chrWidth-16):c=2*r.config.chrWidth-24,p.showChromosomeLabels){const t=a.querySelector(".chrLabel > tspan");t.setAttribute("x",c),t.setAttribute("dy",d-8),a.querySelector(".chrLabel").setAttribute("text-anchor","start")}a.setAttribute("transform","rotate(90) translate("+i+","+s+")"),a.querySelector(".chromosome").setAttribute("transform","translate(-13, 10)")}!function(t){t.config.taxids.forEach((e,n)=>{var r=t.organisms[e].scientificName;To.select(t.selector).append("text").attr("class","genomeLabel italic").attr("x",50+200*n).attr("y",10).text(r).attr("text-anchor","middle")})}(r)}var Zo=function(t){var e,n,r,o,a=t.config;if(t.config.annotLabelHeight=12,"demarcateCollinearChromosomes"in t.config==!1&&(t.config.demarcateCollinearChromosomes=!0),-40,Xo(e=document.querySelectorAll(".chromosome-set"),n=function(t,e){var n,r,o,a,i,c,s,l={};for(n=[],r=0;r<t.length;r++)s=e.chromosomesArray[r].id.split("-")[1],o=0===r?r:r-1,a=e.chromosomesArray[o],0===r||s in l==!1?(i=20,l[s]=1):(c=a.width,i=n[o]+c+(e.config.showChromosomeLabels?0:2)+e.config.chrMargin),n.push(i);return n}(e,t),-40,t),o=Math.round(n.slice(-1)[0]+70),a.multiorganism){r*=8;var i=0;n.forEach(t=>{t>i&&(i=t)}),r=i+30}else r=xOffsets.slice(-1)[0]+30;To.select(t.selector).attr("height",r).attr("width",o),To.select("#_ideogramTrackLabelContainer").remove(),To.select("#_ideogramInnerWrap").insert("div",":first-child").attr("id","_ideogramTrackLabelContainer").style("position","absolute")};function Jo(t,e,n,r){var o,a,i,c,s,l,u,p=r.config,d=p.chrWidth,h=p.chrLabelSize;for(o=0;o<t.length;o++)a=t[o],c=e[o],i=r.chromosomesArray[o].id.split("-")[1],s=n+200*(l=p.taxids.indexOf(i)),0===l&&r.config.multiorganism?(u=h-4,s+=2*d+h):u=2*d+h+2,r.config.showChromosomeLabels&&(a.querySelector(".chrLabel").setAttribute("y",u),a.querySelector(".chrLabel").setAttribute("text-anchor","middle")),a.setAttribute("transform","translate("+c+","+s+")"),a.querySelector(".chromosome").setAttribute("transform","translate(-13, 10)");p.multiorganism&&function(t){t.config.taxids.forEach((e,n)=>{var r=t.organisms[e],o=t.config,a=r.scientificName;To.select(t.selector).append("text").attr("class","genomeLabel italic").attr("x",5).attr("y",o.chrLabelSize+(200+3*o.chrWidth)*n).text(a)})}(r)}var ta=function(t){var e,n,r,o,a,i=t.config,c=i.annotationHeight||0;if("vertical"!==i.orientation){t.config.annotLabelHeight=12;var s=t.config.annotLabelHeight;if("demarcateCollinearChromosomes"in t.config==!1&&(t.config.demarcateCollinearChromosomes=!0),e=document.querySelectorAll(".chromosome-set"),r=i.numAnnotTracks*(c+s+4)-i.chrWidth+1,Jo(e,n=function(t,e){var n,r,o,a,i,c,s,l={};for(n=[],r=0;r<t.length;r++)s=e.chromosomesArray[r].id.split("-")[1],o=0===r?r:r-1,a=e.chromosomesArray[o],0===r||s in l==!1?(i=20,l[s]=1):(c=a.width,i=n[o]+c+(e.config.showChromosomeLabels?0:2)+e.config.chrMargin),n.push(i);return n}(e,t),r,t),o=r+2*i.chrWidth+20,i.multiorganism){o*=8;var l=0;n.forEach(t=>{t>l&&(l=t)}),a=l+20}else a=n.slice(-1)[0]+20;To.select(t.selector).attr("width",a).attr("height",o),To.select("#_ideogramTrackLabelContainer").remove(),To.select("#_ideogramInnerWrap").insert("div",":first-child").attr("id","_ideogramTrackLabelContainer").style("position","absolute")}else Zo(t)};function ea(t){void 0!==t.timeout&&window.clearTimeout(t.timeout),t.rawAnnots=t.setOriginalTrackIndexes(t.rawAnnots),t.config.annotationsDisplayedTracks?t.annots=t.updateDisplayedTracks(t.config.annotationsDisplayedTracks):(t.annots=t.processAnnotData(t.rawAnnots),t.config.filterable&&t.initCrossFilter(),t.drawProcessedAnnots(t.annots))}function na(t){var e=(new Date).getTime(),n=this.config,r=n.annotations;this.initDrawChromosomes(),n.annotationsPath&&function(t){t.rawAnnots?ea(t):function e(){t.timeout=setTimeout((function(){!t.rawAnnots||t.rawAnnots&&void 0!==t.rawAnnots.then?e():ea(t)}),50)}()}(this),function(t,e){var n,r,o,a;if(!0===t.showBandLabels&&(o=(new Date).getTime(),e.hideUnshownBandLabels(),a=(new Date).getTime(),t.debug&&console.log("Time in showing bands: "+(a-o)+" ms"),"vertical"===t.orientation))for(n=0;n<e.chromosomesArray.length;n++)r="#"+e.chromosomesArray[n].id,e.rotateChromosomeLabels(To.select(r),n);!0===t.showChromosomeLabels&&e.drawChromosomeLabels(e.chromosomes)}(n,this),n.brush?this.createBrush(n.brush):n.cursorPosition&&this.createClickCursor(n.cursorPosition),r&&(Array.isArray(r)?this.drawAnnots(r):(this.rawAnnots=r,this.afterRawAnnots(),ea(this))),function(t,e,n){var r=(new Date).getTime();t.debug&&console.log("Time in drawChromosome: "+(r-n)+" ms");var o=(new Date).getTime();t.debug&&console.log("Time constructing ideogram: "+(o-e)+" ms")}(n,t,e),this.setOverflowScroll(),"collinear"===n.geometry&&ta(this),this.onLoadCallback&&this.onLoadCallback()}class ra{constructor(t){this._config=t,this._description=this._normalize(this._config.ploidyDesc)}getChromosomesNumber(t){if(this._config.ploidyDesc){var e=this._config.ploidyDesc[t];return e instanceof Object?Object.keys(e)[0].length:e.length}return this._config.ploidy||1}_normalize(t){var e,n,r=[];if(!t)return t;for(e in t)"string"==typeof(n=t[e])?("vertical"===this._config.orientation&&(n=n.split("").reverse()),r.push({ancestors:n,existence:this._getexistenceArray(n.length)})):r.push({ancestors:Object.keys(n)[0],existence:n[Object.keys(n)[0]]});return r}_getexistenceArray(t){for(var e=[],n=0;n<t;n++)e.push("11");return e}getSetSize(t){return this._description?this._description[t].ancestors.length:1}getAncestor(t,e){return this._description?this._description[t].ancestors[e]:""}exists(t,e,n){if(this._description){var r=this._description[t].existence[e][n];return Number(r)>0}return!0}}class oa{constructor(t){this._node=t}getLabel(){return To.select(this._node.parentNode).select("text.chrLabel").text()}getSetLabel(){return To.select(this._node.parentNode).select("text.chrSetLabel").text()}}var aa=class{constructor(t,e){if(this._config=t,this._ideo=e,this._ploidy=this._ideo._ploidy,this._translate=void 0,"chrSetMargin"in t)this.chrSetMargin=t.chrSetMargin;else{var n=this._config.chrMargin;this.chrSetMargin=this._config.ploidy>1?n:0}this._tickSize=8,this._isRotated=!1}_getLeftMargin(){return this.margin.left}_getYScale(){return 20/this._config.chrWidth}getChromosomeLabels(t){var e=new oa(t),n=[];return this._ideo.config.ploidy>1&&n.push(e.getSetLabel()),n.push(e.getLabel()),n.filter((function(t){return t.length>0}))}getChromosomeBandLabelTranslate(t){var e,n,r,o=this._ideo,a=this._tickSize,i=o.config.orientation;return"vertical"===i?r="rotate(-90)translate("+(e=a)+","+(n=o.round(2+t.px.start+t.px.width/2))+")":"horizontal"===i&&(r="translate("+(e=o.round(-a+t.px.start+t.px.width/2))+","+(n=-10)+")"),{x:e,y:n,translate:r}}didRotate(t,e){var n,r,o,a,i,c,s,l,u;r=(n=this._ideo).config.taxid,o=e.id.split("-")[0].replace("chr",""),a=(i=n.chromosomes[r][o]).bands,l=(s=To.select(e.parentNode)).attr("transform"),u=/scale\(.*\)/.exec(l),l=l.replace(u,""),s.attr("transform",l),c=i.width,(i=n.getChromosomeModel(a,o,r,t)).oldWidth=c,n.chromosomes[r][o]=i,n.drawChromosome(i),n.handleRotateOnClick(),n.rawAnnots&&(n.displayedTrackIndexes?n.updateDisplayedTracks(n.displayedTrackIndexes):(n.annots=n.processAnnotData(n.rawAnnots),n.drawProcessedAnnots(n.annots),n.config.filterable&&n.initCrossFilter())),!0===n.config.showBandLabels&&(n.drawBandLabels(n.chromosomes),n.hideUnshownBandLabels()),n.onDidRotateCallback&&n.onDidRotateCallback(i)}rotate(t,e,n){var r,o,a,i;r=this._ideo,i=r.selector+" .chrSetLabel, "+r.selector+" .chrLabel",a=document.querySelector(r.selector).getBoundingClientRect(),o=To.selectAll(r.selector+" g.chromosome").filter((function(){return this!==n})),this._isRotated?(this._isRotated=!1,r.config.chrHeight=r.config.chrHeightOriginal,r.config.chrWidth=r.config.chrWidthOriginal,r.config.annotationHeight=r.config.annotationHeightOriginal,this.rotateBack(t,e,n,(function(){o.style("display",null),To.selectAll(i).style("display",null),r._layout.didRotate(e,n)}))):(this._isRotated=!0,o.style("display","none"),To.selectAll(i).style("display","none"),this.rotateForward(t,e,n,(function(){var t,o,i;r.config.chrHeightOriginal=r.config.chrHeight,r.config.chrWidthOriginal=r.config.chrWidth,r.config.annotationHeightOriginal=r.config.annotationHeight;"VerticalLayout"===r._layout._class?(o=a.width-20,i=window.innerWidth-20):(o=a.height-10,i=window.innerHeight-10),t=i<o?i:o,t-=2*r.config.chrMargin,r.config.chrHeight=t,r.config.chrWidth*=2.3,r.config.annotationHeight*=1.7,r._layout.didRotate(e,n)})))}getChromosomeLabelClass(){return 1===this._config.ploidy?"chrLabel":"chrSetLabel"}_getAdditionalOffset(){var t=this._config,e=t.annotationsNumTracks||t.numAnnotTracks||1;return(t.annotationHeight||0)*e}_getChromosomeSetSize(t){return this._ploidy.getSetSize(t)*this._config.chrWidth*2+this.chrSetMargin}getChromosomeSetLabelAnchor(){return"middle"}getChromosomeLabelYPosition(){return-5.5}getChromosomeSetLabelYPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelYPosition(t):-2*this._config.chrWidth}};var ia=class extends aa{constructor(t,e){super(t,e),this._class="VerticalLayout",this.margin={top:30,left:15}}rotateForward(t,e,n,r){var o="translate(20, 25) "+this.getChromosomeScale(n);To.select(n.parentNode).transition().attr("transform",o).on("end",r);var a=this.getChromosomeLabels(n),i=1.3*(20+this._config.chrWidth);To.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(a).enter().append("text").attr("class",(function(t,e){return 0===e&&2===a.length?"chrSetLabel":null})).attr("x",0).attr("y",i).style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="horizontal"}rotateBack(t,e,n,r){var o=this.getChromosomeScaleBack(n),a=this.getChromosomeSetTranslate(t);To.select(n.parentNode).transition().attr("transform",a+" "+o).on("end",r),To.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="vertical"}getHeight(){return this._config.chrHeight+1.5*this.margin.top}getWidth(){return"97%"}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeBandLabelAnchor(){return null}getChromosomeScale(t){var e,n;return e=To.select(this._ideo.selector).node().getBoundingClientRect(),n=t.getBoundingClientRect(),"scale("+e.width/n.height*.97+", "+this._getYScale()+")"}getChromosomeScaleBack(t){var e,n,r;return n=(r=this._ideo.config).taxid,e=t.id.split("-")[0].replace("chr",""),"scale("+this._ideo.chromosomes[n][e].oldWidth/(3*r.chrHeight)*.97+", "+1/this._getYScale()+")"}getChromosomeSetTranslate(t){return"rotate(90) translate("+this.margin.top+", -"+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){var e,n=this._getAdditionalOffset(),r=this._config.chrMargin,o=this._config.chrWidth;if(!this._config.ploidyDesc)return"histogram"===this._config.annotationsLayout?r+t*(r+o+3)+2*this._ideo.config.barWidth:(e=o+t*(r+o)+2*n,n>0?e:e+4+2*t);if(!this._translate){var a;this._translate=[this._ploidy.getSetSize(0)*o*2];for(var i=1;i<this._config.ploidyDesc.length;i++)a=this._translate[i-1],this._translate[i]=a+this._getChromosomeSetSize(i-1)}return this._translate[t]}getChromosomeSetLabelXPosition(){return this._config.chrWidth*this._config.ploidy/-2}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}};var ca=class extends aa{constructor(t,e){super(t,e),this._class="HorizontalLayout",this.margin={left:20,top:30}}_getLeftMargin(){var t=aa.prototype._getLeftMargin.call(this);return this._config.ploidy>1&&(t*=1.8),t}rotateForward(t,e,n,r){var o;To.select(n.parentNode).transition().attr("transform","rotate(90) translate(30, -37.5) ").on("end",r),o=this.getChromosomeLabels(n),To.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(o).enter().append("text").attr("class",(function(t,e){return 0===e&&2===o.length?"chrSetLabel":null})).attr("x",26).attr("y",(function(t,e){return 12*(e+1+o.length%2)})).style("text-anchor","middle").style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="vertical"}rotateBack(t,e,n,r){var o=this.getChromosomeSetTranslate(t);To.select(n.parentNode).transition().attr("transform",o).on("end",r),To.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="horizontal"}getHeight(t){void 0===t&&(t=this._config.taxids[0]);var e=this._config.chromosomes[t].length,n=this.getChromosomeSetYTranslate(e-1);return(n+=this._getChromosomeSetSize(e-1))+2*this._getAdditionalOffset()}getWidth(){return this._config.chrHeight+1.5*this.margin.top}getChromosomeSetLabelAnchor(){return"end"}getChromosomeBandLabelAnchor(){return null}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return null}getChromosomeSetTranslate(t){return"translate("+this._getLeftMargin()+", "+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){if(!this._config.ploidyDesc)return this._config.chrMargin*(t+1);if(!this._translate){this._translate=[1];for(var e=1;e<this._config.ploidyDesc.length;e++)this._translate[e]=this._translate[e-1]+this._getChromosomeSetSize(e-1)}return this._translate[t]}getChromosomeSetLabelXPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelXPosition(t):-20}getChromosomeSetLabelYPosition(t){var e=this._ploidy.getSetSize(t),n=this._config,r=n.chrMargin,o=n.chrWidth;return 1===n.ploidy?o/2+3:e*r/2}getChromosomeLabelXPosition(){return-8}getChromosomeLabelYPosition(){return this._config.chrWidth}};var sa=class extends aa{constructor(t,e){super(t,e),this._class="PairedLayout",this.margin={left:30}}getHeight(){return this._config.chrHeight+1.5*this.margin.left}getWidth(){return"97%"}getChromosomeBandTickY1(t){return t%2?this._config.chrWidth:2*this._config.chrWidth}getChromosomeBandTickY2(t){var e=this._config.chrWidth;return t%2?e-this._tickSize:2*e+this._tickSize}getChromosomeBandLabelAnchor(t){return t%2?null:"end"}getChromosomeBandLabelTranslate(t,e){var n=e%2?10:-this._config.chrWidth-10,r=this._ideo.round(t.px.start+t.px.width/2)+3;return{x:r,y:r,translate:"rotate(-90) translate("+n+", "+r+")"}}getChromosomeLabelXPosition(){return-this._tickSize}getChromosomeSetLabelXPosition(){return this._config.chrWidth/-2}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var e=this.getChromosomeSetYTranslate(t);return"rotate(90) translate("+this.margin.left+", -"+e+")"}getChromosomeSetYTranslate(t){return 200*(t+1)}};var la=class extends aa{constructor(t,e){super(t,e),this._class="SmallLayout",this.margin={left:36.5,top:10};var n=this._ideo.getTaxid(this._ideo.config.organism);this.chrs=t.chromosomes[n];var r=this.chrs.length;this.chrsPerRow=Math.ceil(r/t.rows)}getHeight(){var t=1.25*this._config.chrHeight;return this._config.rows*(t+this.margin.top)}getWidth(){return"97%"}getChromosomeBandLabelTranslate(){}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var e,n;return t>this.chrsPerRow-1?(e=this.margin.left+1.3*this._config.chrHeight,n=this.getChromosomeSetYTranslate(t-this.chrsPerRow)):(e=this.margin.left,n=this.getChromosomeSetYTranslate(t)),"rotate(90) translate("+e+", -"+n+")"}getChromosomeSetYTranslate(t){var e=.3*this._getAdditionalOffset();return this.margin.left*t+this._config.chrWidth+2*e+e*t}getChromosomeSetLabelXPosition(t){return(this._ploidy.getSetSize(t)*this._config.chrWidth+20)/-2+(this._config.ploidy>1?0:this._config.chrWidth)}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}};function ua(t){this.config.annotationsPath&&this.fetchAnnots(this.config.annotationsPath),function(t){if("ploidyDesc"in t.config&&"string"==typeof t.config.ploidyDesc){for(var e=[],n=0;n<t.numChromosomes;n++)e.push(t.config.ploidyDesc);t.config.ploidyDesc=e}t._ploidy=new ra(t.config)}(this),this._layout=function(t){var e=t.config;return"perspective"in e&&"comparative"===e.perspective?new sa(e,t):"rows"in e&&e.rows>1?new la(e,t):"vertical"===e.orientation?new ia(e,t):"horizontal"===e.orientation?new ca(e,t):new ia(e,t)}(this),function(t){To.selectAll(t.config.container+" #_ideogramOuterWrap").remove(),To.select(t.config.container).append("div").attr("id","_ideogramOuterWrap").append("div").attr("id","_ideogramTrackLabelContainer").style("position","absolute"),To.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("id","_ideogramMiddleWrap").style("position","relative").style("overflow-x","auto").style("transform","translateZ(0)").append("div").attr("id","_ideogramInnerWrap").append("svg").attr("id","_ideogram").attr("class",function(t){var e="";return t.config.showChromosomeLabels&&("horizontal"===t.config.orientation?e+="labeledLeft ":e+="labeled "),!1===t.config.rotatable&&(e+="no-rotate "),t.config.annotationsLayout&&"overlay"===t.config.annotationsLayout&&(e+="faint"),e}(t)).attr("width",t._layout.getWidth()).attr("height",t._layout.getHeight()).html(t.getBandColorGradients())}(this),this.isOnlyIdeogram=1===document.querySelectorAll("#_ideogram").length,function(t){To.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("class","_ideogramTooltip").attr("id","_ideogramTooltip").style("opacity",0).style("position","fixed").style("text-align","center").style("padding","4px").style("font","12px sans-serif").style("background","white").style("border","1px solid black").style("border-radius","5px").style("z-index","1000")}(this),this.finishInit(t)}var pa="";function da(t,e,n){return n.config.dataDir+t[e]}function ha(t,e,n){var r=n.config.ploidy;return"sex"in n.config&&(2===r&&n.sexChromosomes.index+1===e||"female"===n.config.sex&&"Y"===t.name)}function fa(t,e,n,r){var o,a,i,c,s;for(o=0;o<e.length;o++)i=e[o],void 0!==t&&(a=t[o]),s=o+r.config.taxids.indexOf(n),c=r.getChromosomeModel(a,i,n,s),"string"!=typeof i&&(i=i.name.split(" ").slice(-1)[0].replace("chr","")),r.chromosomes[n][i]=c,r.chromosomesArray.push(c),ha(c,o,r)||r.drawChromosome(c)}function ma(t,e){"undefined"!=typeof chrBands&&t.length>=chrBands.length/2&&(e.coordinateSystem="bp")}function ga(){var t,e,n,r,o=this.config.taxids;for(e=0;e<o.length;e++)t=o[e],n=this.config.chromosomes[t],r=this.bandsArray[t],this.config.showNonNuclearChromosomes||(n=n.filter(t=>"MT"!==t),void 0!==r&&(r=r.filter(t=>"MT"!==t[0].chr))),ma(n,this),this.chromosomes[t]={},this.setSexChromosomes(n),fa(r,n,t,this),this.config.showBandLabels&&this.drawBandLabels(this.chromosomes),this.handleRotateOnClick(),this._gotChrModels=!0}function va(){var t=this;"rotatable"in t.config&&!1===t.config.rotatable?To.selectAll(t.selector).style("cursor","default"):To.selectAll(t.selector+" .chromosome-set").on("click",(function(){const e=this.children[1];t.rotateAndToggleDisplay(e)}))}function ba(){call(this.onLoadCallback)}function ya(t,e,n){var r=n.organisms[t],o=[Po(r.scientificName)],a=r.assemblies,i=n.config.resolution;e!==a.default&&o.push(e),"9606"===t&&(e in a==="false"&&Object.values(a).includes(config.assembly)||""!==i&&850!==i)&&o.push(i),o=o.join("-");return["9606","10090","10116"].includes(t)&&!n.config.showFullyBanded&&(o+="-no-bands"),o+=".json"}function Sa(t,e,n){var r,o,a,i=n.config;return r=n.organisms[t],i.assembly||(n.config.assembly="default"),o=r.assemblies,a=ya(t,n.assemblyIsAccession()?i.assembly:o[i.assembly],n),t in n.organismsWithBands&&(e[t]=a),e}function Ca(t,e,n,r){return function(t,e,n){var r=da(t,e,n);return(!(void 0!==window.chrBands&&""===pa)||pa!==r)&&function(t){return"assembly"in t.config&&!1===/(GCA_)/.test(t.config.assembly)}(n)&&e in t}(e,t,r)?function(t,e,n,r){var o=da(t,e,r);return r.numBandDataResponses||(r.numBandDataResponses=0),fetch(o).then((function(e){return e.json().then((function(n){pa=o,delete window.chrBands,window.chrBands=n.chrBands,function(t,e,n,r){var o,a,i;for(o in e)i=e[o],t.includes(i)&&""!==i&&(a=o);r.bandData[a]=n}(e.url,t,chrBands,r)}))}))}(e,t,0,r).then((function(){return r.processBandData(t)})):new Promise((function(e){r.processBandData(t),e([t,void 0])}))}var xa={},_a={},wa={};function za(t){var e=(t=t||this).config.container;wa[e]?(_a[e]=!0,xa[e]=t):(wa[e]=!0,function(t){return new Promise((function(e){if("number"==typeof t.config.organism){var n=t.config.organism;t.getOrganismFromEutils(n,(function(){t.getTaxids(e)}))}else t.getTaxids(e)}))}(t).then((function(n){var r=n[0];t.config.taxid=r,t.config.taxids=n,function(t,e,n){var r,o,a,i=[];for(a in r={},Yo)r[a]="";for(o=0;o<t.length;o++)r=Sa(a=String(t[o]),r,n),i.push(Ca(a,r,0,n));Promise.all(i).then((function(t){var r,a,i;for(o=0;o<t.length;o++)a=(r=t[o])[0],i=r[1],"bandsArray"in n==!1&&(n.bandsArray={}),n.bandsArray[a]=i;n.writeContainer(e)}))}(n,(new Date).getTime(),t),wa[e]=!1,_a[e]&&(_a[e]=!1,za(xa[e]))})))}class Ea{constructor(t,e){this.rawAnnots=this.parseBed(t,e)}static componentToHex(t){var e=parseInt(t,10).toString(16);return 1===e.length?"0"+e:e}static rgbToHex(t,e,n){return"#"+Ea.componentToHex(t)+Ea.componentToHex(e)+Ea.componentToHex(n)}parseGenomicCoordinates(t,e){var n,r,o,a;return n=t[0],r=parseInt(t[1],10),a=(o=parseInt(t[2],10))-r,e&&(n=n.slice(3)),[n,r,o,a]}parseAnnotFromTsvLine(t,e,n){var r,o,a,i,c,s,l,u=t.split(/\s/g);return[a,i,stop,length]=this.parseGenomicCoordinates(u,n),-1===(o=e.indexOf(a))?[null,null]:(r=["",i,length,0],u.length>=4&&(l=u[3],r[0]=l),u.length>=8&&(c=u[8].split(","),s=Ea.rgbToHex(c[0],c[1],c[2]),r.push(s)),[o,r])}parseRawAnnots(t,e,n,r){var o,a,i,c,s,l;for(l=!0,!1===isNaN(parseInt(n[e],10))&&(l=!1),o=e;o<n.length;o++)a=n[o],[i,c]=this.parseAnnotFromTsvLine(a,r,l),null!==i&&t[i].annots.push(c);return s=["name","start","length","trackIndex"],n[e].length>=8&&s.push("color"),{keys:s,annots:t}}parseBed(t,e){var n,r,o,a,i=[],c=t.split(/\r\n|\n/);for(r=Object.keys(e.chromosomes[e.config.taxid]),n=0;n<r.length;n++)o=r[n],i.push({chr:o,annots:[]});return a=0,("chr"===c[0].slice(0,3)||isNaN(parseInt(c[0],10)))&&(a=1),this.parseRawAnnots(i,a,c,r)}}var Ma=["name","start","length","trackIndex","trackIndexOriginal","color"],qa={3:["00B","DDD","F00"],5:["00D","66D","DDD","F88","F00"],17:["00D","00D","00D","00D","00D","44D","44D","DDD","DDD","DDD","DDD","F88","F66","F22","F22","F00","F00","F00"]};function ka(t){var e,n,r;if(t.rawAnnots.metadata&&t.rawAnnots.metadata.trackLabels)e=t.rawAnnots.metadata.trackLabels;else if(t.config.heatmaps)for(e=[],n=t.config.heatmaps,r=0;r<n.length;r++)e.push(n[r].key);else e=t.rawAnnots.keys.slice(0).filter(t=>!Ma.includes(t));return t.displayedTrackIndexes&&(e=e.filter((function(e,n){return t.displayedTrackIndexes.includes(n+1)}))),e}function Ga(t){var e,n,r=t.rawAnnots;if(!r.metadata||r.metadata.heatmapThresholds||t.config.heatmapThresholds)return e=t.config.heatmapThresholds?t.config.heatmapThresholds:t.rawAnnots.metadata.heatmapThresholds,n=qa[e.length+1],(e=e.map((t,e)=>[t,"#"+n[e]])).push(["+","#"+n.slice(-1)[0]]),e}function La(t,e,n,r,o){return t===e&&"+"===o&&n>r||n===o||0!==t&&t!==e&&n<=o&&n>r||0===t&&n<=o}function Oa(t,e){var n,r,o,a,i,c,s,l;for(n=0;n<t.length;n++)r=t.length-1,a=(o=t[n])[0],i=parseFloat(a),!1===isNaN(i)&&(a=i),0!==n&&(s=parseFloat(t[n-1][0])),c=o[1],La(n,r,e,s,a)&&(l=c);return l}function Ta(t){!function(t,e){var n,r,o,a,i=e.config.annotLabelHeight;for(11,a=e.config.demarcateCollinearChromosomes?2:0,(o=To.select(e.config.container+" #_ideogramTrackLabelContainer")).html(""),r=e.config.annotationHeight+i+4,n=0;n<t.length;n++)o.style("position","absolute").append("div").attr("class","_ideogramTrackLabel").style("opacity",1).style("position","absolute").style("text-align","center").style("padding","1px").style("font","11px sans-serif").style("background","white").style("line-height","10px").style("z-index","5").style("left",11+a+"px").style("top",r*n+a+"px").style("width","max-content").style("transform-origin","bottom left").style("text-align","left").html(t[n])}(ka(t),t)}function Aa(t,e,n){var r,o,a,i,c,s=t.width,l=[],u=n.config.annotLabelHeight,p=n.config.numAnnotTracks;for(r=0;r<p;r++)a=n.config.annotationHeight+u+4,c=t.id+"-canvas-"+r,o=e,t.chrIndex>0&&(o+=n.config.chrMargin*t.chrIndex-1),i=To.select(n.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",c).attr("width",s+1).attr("height",a).style("position","absolute").style("left",o+"px").style("top",a*r+1+"px").nodes()[0].getContext("2d"),l.push([i,t]);return l}function Ra(t,e,n){var r,o,a,i,c=n.config.annotLabelHeight,s=n.config.annotationHeight,l=n.config.demarcateCollinearChromosomes,u=s+c+4;for(r=0;r<t.length;r++)if(a=e[(o=t[r]).trackIndex][0],i=e[o.trackIndex][1],a.fillStyle=o.color,l){if(o.startPx<1||o.startPx>i.width-1)continue;a.fillRect(o.startPx,1,.5,u)}else a.fillRect(o.startPx,c+1,.5,s);if(l)for(r=0;r<e.length;r++)a=e[r][0],i=e[r][1],a.fillStyle="#555",0===i.chrIndex&&a.fillRect(0,0,1,u),a.fillRect(i.width-1,0,1.1,u),a.fillRect(0,0,i.width+1,1),n.config.chrMargin&&a.fillRect(0,0,1.1,u)}function Fa(t,e,n){var r,o,a,i=n.config.annotationHeight,c=n._layout.margin.top;for(a=t.values,r=0;r<a.length;r++)e.fillStyle=a[r],o=(r-1)*i,e.fillRect(o,t.startPx+c,i,2)}function Ia(t,e){var n,r,o=e.config.container,a=e._layout.margin.top,i=e.config.chrHeight+a,c=e.config.annotationHeight*t[0].values.length;for(To.selectAll(o+" canvas").remove(),To.select(o+" #_ideogramInnerWrap").style("max-width",c+"px"),To.select(o+" #_ideogram").attr("width",c),n=function(t,e,n,r){var o,a;return a=t.id+"-canvas",o=2*r.config.chrWidth+r.config.annotationHeight-.5,To.select(r.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",a).attr("width",n).attr("height",e).style("position","absolute").style("left",o+"px").style("top","0px").nodes()[0].getContext("2d")}(e.chromosomesArray[0],i,c,e),r=0;r<t.length;r++)Fa(t[r],n,e);e.onDrawAnnotsCallback&&e.onDrawAnnotsCallback()}function Ha(t,e,n,r,o,a,i){var c,s,l,u,p,d,h,f=i.config.heatmapThresholds;for(c=0;c<n.annots.length;c++){for(u=n.annots[c],(l={}).values=[],s=0;s<3;s++)l[a[s]]=u[s];for(s=3;s<a.length;s++)h=Oa(f,u[s]),l.values.push(h);p=l.start+l.length,l.chr=n.chr,l.chrIndex=o,l.startPx=i.convertBpToPx(r,l.start),d=i.convertBpToPx(r,p),l.px=Math.round((l.startPx+d)/2),t.push(l)}return t.shift(),[t,e]}function Da(t){!1!==t.config.showTrackLabel&&(t.hideTrackLabelTimeout=window.setTimeout((function(){To.select(t.config.container+" #_ideogramTrackLabel").transition().duration(500).style("opacity",0)}),250))}function Ba(t,e){var n,r,o;clearTimeout(e.hideTrackLabelTimeout),n=(n=ka(e)).join("<br>"),To.select(e.config.container+" #_ideogramTrackLabel").interrupt().style("top","").style("left","").style("transform",null).style("transform","rotate(-90deg)").html(n),[r,o]=function(t,e,n){var r,o,a,i,c;return r=e.id.split("-").slice(0,-1).join("-")+"-0",o=To.select(n.config.container+" #"+r).nodes()[0].getBoundingClientRect(),a=To.select(n.config.container+" #_ideogramTrackLabel").nodes()[0].getBoundingClientRect(),i=To.select(n.config.container).nodes()[0].getBoundingClientRect(),c=Math.round(o.left+a.width)-o.width-1,[c-=i.left-7,-(t.split("<br>").length-2)*o.width+2]}(n,t,e),function(t,e,n){To.select(n.config.container+" #_ideogramTrackLabel").style("opacity",1).style("left",e+"px").style("top",t+"px").style("width","max-content").style("transform-origin","bottom left").style("text-align","left").on("mouseover",(function(){clearTimeout(n.hideTrackLabelTimeout)})).on("mouseout",(function(){Da(n)}))}(o,r,e)}function Va(t,e,n,r){var o,a,i,c,s,l=[],u=r.config.numAnnotTracks;for(o=0;o<u;o++)i=r.config.annotationHeight,s=t.id+"-canvas-"+o,a=e-i*(u-o)-7,c=To.select(r.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",s).attr("width",i).attr("height",n).style("position","absolute").style("left",a+"px").nodes()[0].getContext("2d"),l.push(c);return 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0===this.maxAnnotsPerBar&&(this.maxAnnotsPerBar={},r=!0),function(t,e,n){var r,o,a,i,c,s,l;if(e||"relative"===n.config.histogramScaling){for(r=0,o=0;o<t.length;o++){for(a=0,i=t[o].annots,c=t[o].chr,s=0;s<i.length;s++)(l=i[s].count)>a&&(a=l),l>r&&(r=l);n.maxAnnotsPerBar[c]=a}n.maxAnnotsPerBarAllChrs=r}}(n=function(t,e,n,r){var o,a,i,c,s,l,u,p,d,h,f=r.config.barWidth;for(o in t)for(a=t[o].annots,c=e[(i=n[t[o].chr]).chrIndex].annots,s=0;s<a.length;s++)for(u=(l=a[s]).px-r.bump,p=0;p<c.length;p++)if(h=(d=c[p].px)+f,p===c.length-1&&(h+=f),u>=d&&u<h){e[i.chrIndex].annots[p].count+=1,e[i.chrIndex].annots[p].annots.push(l);break}return e}(t,n=function(t,e){var n,r,o,a,i,c,s,l=e.config.barWidth,u=[];for(n in t){for(o=(r=t[n]).bands[r.bands.length-1],a=Math.round(o.px.stop/l),i={chr:n,annots:[]},c=0;c<a;c++)s=c*l-e.bump,i.annots.push({bp:e.convertPxToBp(r,s+e.bump),px:s,count:0,chrIndex:r.chrIndex,chrName:n,color:e.config.annotationsColor,annots:[]});u.push(i)}return u}(e,this),e,this),r,this),n=function(t,e){var n,r,o,a,i,c,s,l=e._layout._isRotated;for(n=0;n<t.length;n++)for(r=t[n].annots,o=t[n].chr,a=0;a<r.length;a++)i=r[a].count,c="relative"===e.config.histogramScaling?i/e.maxAnnotsPerBar[o]:i/e.maxAnnotsPerBarAllChrs,s=!1===l?c*e.config.chrMargin:c*e.config.chrHeightOriginal*3,isNaN(s)&&(s=0),t[n].annots[a].height=s;return t}(n,this),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time spent in getHistogramBars: "+(n-t)+" ms")}(o,this),this.bars=n,n}function Ja(t,e){var n,r='fill="'+t.color+'" style="stroke: #AAA;"',o=t.shape;if('d="m7,3 l -5 9 l 9 0 z"','d="m2,9a 4.5,4.5 0 1,0 9,0a 4.5,4.5 0 1,0 -9,0"','height="10" width="10" y="3"',"shape"in t&&["circle","triangle"].includes(o)){if("circle"===o)n='<path d="m2,9a 4.5,4.5 0 1,0 9,0a 4.5,4.5 0 1,0 -9,0" '+r+"></path>";else if("triangle"===o){var a="";"vertical"===e.config.orientation&&(a=' transform="rotate(90, 7, 7)"'),n='<path d="m7,3 l -5 9 l 9 0 z"'+a+" 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n,r;if(!/heatmap/.test(t)&&"histogram"!==t){for(r=0,n=0;n<e.length;n++)r+=e[n].annots.length;r>2e3&&console.warn('Rendering more than 2000 annotations in Ideogram?\nTry setting "annotationsLayout" to "heatmap" or "histogram" in your Ideogram configuration object for better layout and performance.')}}(t,e),"histogram"===t&&(e=n.getHistogramBars(e)),r=function(t,e){return To.selectAll(e.selector+" .chromosome").data(t).selectAll("path.annot").data((function(t){return t.annots})).enter()}(n.fillAnnots(e),n),"tracks"===t?function(t,e){var n,r=e.config.annotationHeight;n=function(t){var e;return{triangle:"m0,0 l -"+t+" "+2*t+" l "+2*t+" 0 z",circle:"m -"+(e=t)+", "+e+"a "+e+","+e+" 0 1,0 "+2*e+",0a "+e+","+e+" 0 1,0 -"+2*e+",0",rectangle:"m0,0 l 0 "+2*t+"l "+t+" 0l 0 -"+2*t+"z"}}(r),t.append("g").attr("id",(function(t){return t.id})).attr("class","annot").attr("transform",(function(t){var n=e.config.chrWidth+t.trackIndex*r*2;return"translate("+t.px+","+n+")"})).append("path").attr("d",(function(t){return function(t,e){return t.shape&&"triangle"!==t.shape?"circle"===t.shape?e.circle:"rectangle"===t.shape?e.rectangle:t.shape:e.triangle}(t,n)})).attr("fill",(function(t){return t.color})).on("mouseover",(function(t,n){e.showAnnotTooltip(n,this)})).on("mouseout",(function(){e.startHideAnnotTooltipTimeout()})).on("click",(function(t,n){e.onClickAnnot(n)}))}(r,n):"overlay"===t?function(t,e){t.append("polygon").attr("id",(function(t){return t.id})).attr("class","annot").attr("points",(function(t){var n,r,o=e.config.chrWidth;return t.stopPx-t.startPx>1?(n=t.startPx,r=t.stopPx):(n=t.px-.5,r=t.px+.5),n+","+o+" "+r+","+o+" "+r+",0 "+n+",0"})).attr("fill",(function(t){return t.color})).on("mouseover",(function(t,n){e.showAnnotTooltip(n,this)})).on("mouseout",(function(){e.startHideAnnotTooltipTimeout()}))}(r,n):"histogram"===t&&function(t,e){var n,r,o={},a=e.config.chrWidth;for(r in 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#_ideogramLegend svg {float: left;} #_ideogramLegend ul {position: relative; left: -14px; list-style: none; float: left; padding-left: 10px; margin: 0 0 1em 0; width: auto; border: none;} #_ideogramLegend li {float: none; margin: 0;}#_ideogramLegend ul span {position: relative; left: -15px;} "),c.append("div").attr("id","_ideogramLegend").html(i)}(this),/heatmap/.test(e)?this.drawHeatmaps(t):(ni(e,t,this),this.onDrawAnnotsCallback&&this.onDrawAnnotsCallback())}function oi(t,e,n){return t.append("g").attr("class","syntenicRegion").attr("id",e).on("click",(function(){var t=this,e=To.selectAll(n.selector+" .syntenicRegion").filter((function(){return this!==t}));e.classed("hidden",!e.classed("hidden"))})).on("mouseover",(function(){var t=this;To.selectAll(n.selector+" .syntenicRegion").filter((function(){return this!==t})).classed("ghost",!0)})).on("mouseout",(function(){To.selectAll(n.selector+" .syntenicRegion").classed("ghost",!1)}))}function ai(t,e,n,r,o,a){var i,c;i="color"in a?a.color:"#CFC",c="opacity"in a?a.opacity:1,t.append("polygon").attr("points",e+", "+r.startPx+" "+e+", "+r.stopPx+" "+n+", "+o.stopPx+" "+n+", "+o.startPx).style("fill",i).style("fill-opacity",c)}function ii(t,e,n,r,o,a){var i,c;i="color"in a?a.color:"#CFC",c="opacity"in a?a.opacity:1,t.append("polygon").attr("points",r.startPx-15+", "+e+" "+(r.stopPx-15)+", "+e+" "+(o.stopPx-15)+", "+n+" "+(o.startPx-15)+", "+n).style("fill",i).style("fill-opacity",c)}function ci(t,e,n=null){var r,o,a,i;if(r=t.r1,o=t.r2,"string"==typeof r.chr){const t=e.config.taxids;e.config.multiorganism?(r.chr=e.chromosomes[t[0]][r.chr],o.chr=e.chromosomes[t[1]][o.chr]):(r.chr=e.chromosomes[t[0]][r.chr],o.chr=e.chromosomes[t[0]][o.chr])}var c=document.querySelector("#"+r.chr.id+"-chromosome-set"),s=c.getCTM().e,l=c.getCTM().f,u=document.querySelector("#"+o.chr.id+"-chromosome-set"),p=u.getCTM().e,d=u.getCTM().f;return null===n?"vertical"===e.config.orientation?(a=l-12,i=d-12):(a=s,i=p):(a=n,i=n),r.startPx=e.convertBpToPx(r.chr,r.start)+a,r.stopPx=e.convertBpToPx(r.chr,r.stop)+a,o.startPx=e.convertBpToPx(o.chr,o.start)+i,o.stopPx=e.convertBpToPx(o.chr,o.stop)+i,[r,o]}function si(t,e,n,r,o){t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.startPx).attr("y2",o.startPx),t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.stopPx).attr("y2",o.stopPx)}function li(t,e){var n=(new Date).getTime();(function(t,e,n){var r,o,a,i,c,s,l,u;for(r=0;r<t.length;r++)o=t[r],[a,i]=ci(o,n),ai(c=oi(e,a.chr.id+"_"+a.start+"_"+a.stop+"___"+i.chr.id+"_"+i.start+"_"+i.stop,n),l=(s=n.config.chrWidth)+46,u=s+240,a,i,o),si(c,l,u,a,i)})(t,To.select(e.selector).insert("g",":first-child").attr("class","synteny"),e),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time in drawSyntenicRegions: "+(n-t)+" ms")}(n,e)}function ui(t,e,n,r,o){t.append("line").attr("class","syntenyBorder").attr("x1",r.startPx-15).attr("x2",o.startPx-15).attr("y1",e).attr("y2",n),t.append("line").attr("class","syntenyBorder").attr("x1",r.stopPx-15).attr("x2",o.stopPx-15).attr("y1",e).attr("y2",n)}function pi(t,e){var n=(new Date).getTime();(function(t,e,n){var r,o,a,i,c,s,l,u;for(r=0;r<t.length;r++)o=t[r],[a,i]=ci(o,n),ii(c=oi(e,a.chr.id+"_"+a.start+"_"+a.stop+"___"+i.chr.id+"_"+i.start+"_"+i.stop,n),l=(s=n.config.chrWidth)+31,u=s+191,a,i,o),ui(c,l,u,a,i)})(t,To.select(e.selector).insert("g",":first-child").attr("class","synteny"),e),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time in drawSyntenicRegions: "+(n-t)+" ms")}(n,e)}function di(t,e,n,r,o,a){var i,c;Math.abs(r.startPx-r.startPx)<2&&Math.abs(r.stopPx-r.stopPx)<2?(i=a.color,c=a.width):(i="",c=""),t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.startPx).attr("y2",o.startPx).style("stroke",i).style("stroke-width",c),t.append("line").attr("class","syntenyBorder").attr("x1",e).attr("x2",n).attr("y1",r.stopPx).attr("y2",o.stopPx).style("stroke",i).style("stroke-width",i)}function hi(t,e,n,r,o,a){var i=a.split("__").map(t=>"label_"+t);if("name"in r){t.append("text").attr("id",i[0]).attr("y",r.startPx+3).text(r.name);var c=document.querySelector("#"+i[0]).getBoundingClientRect().width;To.select("#"+i[0]).attr("x",e-15-c)}"name"in o&&t.append("text").attr("id",i[1]).text(o.name).attr("x",n+15).attr("y",o.startPx+3).text(o.name)}function fi(t){var e=(new Date).getTime(),n=this.config;if(n.multiorganism&&"collinear"===n.geometry)return"vertical"===n.orientation?li(t,this):pi(t,this);(function(t,e,n,r){var o,a,i,c,s,l,u,p,d;for(o=0;o<t.length;o++)a=t[o],[i,c]=ci(a,r,n),l=oi(e,s=i.chr.id+"_"+i.start+"_"+i.stop+"___"+c.chr.id+"_"+c.start+"_"+c.stop,r),u=r.config.chrWidth,ai(l,p=r._layout.getChromosomeSetYTranslate(0),d=r._layout.getChromosomeSetYTranslate(1)-u,i,c,a),di(l,p,d,i,c,a),hi(l,p,d,i,c,s)})(t,To.select(this.selector).insert("g",":first-child").attr("class","synteny"),this._layout.margin.left,this),function(t,e){var n=(new Date).getTime();e.config.debug&&console.log("Time in drawSyntenicRegions: "+(n-t)+" ms")}(e,this)}function mi(){this.config.numAnnotTracks=this.config.annotationsNumTracks,To.selectAll(this.selector+" .annot").remove(),this.drawAnnots(this.processAnnotData(this.rawAnnots))}function gi(t){var e,n,r,o=this.rawAnnots.annots;return this.config.numAnnotTracks=t.length,e=function(t,e){var n,r,o,a,i,c,s;for(r=[],a=0;a<t.length;a++){for(o=t[a],i=[],c=0;c<o.annots.length;c++)s=(n=o.annots[c].slice())[3]+1,e.includes(s)&&(n[3]=e.indexOf(s),i.push(n));r.push({chr:o.chr,annots:i})}return r}(o,t),r={keys:this.rawAnnots.keys,annots:e},"collinear"===this.config.geometry&&ta(this),n=this.processAnnotData(r),To.selectAll(this.selector+" .annot").remove(),this.displayedTrackIndexes=t,this.drawAnnots(n),n}function vi(t){var e,n;return(e=t.keys).length<4||"trackIndex"!==e[3]||"trackIndexOriginal"===e[4]||(n=function(t,e){var n,r,o,a,i,c,s,l=[];for(s=1,n=0;n<t.length;n++){for(o=t[n],i=[],r=0;r<o.annots.length;r++)(c=(a=o.annots[r].slice())[3])+1>s&&(s=c+1),a.splice(4,0,c),i.push(a);l.push({chr:o.chr,annots:i})}return e.numAvailTracks=s,l}(t.annots,this),e.splice(4,0,"trackIndexOriginal"),t={keys:e,annots:n},this.rawAnnots.metadata&&(t.metadata=this.rawAnnots.metadata)),t}var bi=[["F00"],["F00","88F"],["F00","CCC","88F"],["F00","FA0","0AF","88F"],["F00","FA0","CCC","0AF","88F"],["F00","FA0","875","578","0AF","88F"],["F00","FA0","875","CCC","578","0AF","88F"],["F00","FA0","7A0","875","0A7","578","0AF","88F"],["F00","FA0","7A0","875","CCC","0A7","578","0AF","88F"],["F00","FA0","7A0","875","552","255","0A7","578","0AF","88F"]];function yi(t,e,n,r,o,a,i){return i.config.annotationTracks?o=function(t,e,n,r,o){var a;return e.trackIndex=n[3],(a=o.config.annotationTracks[e.trackIndex]).color&&(e.color=a.color),a.shape&&(e.shape=a.shape),t[r].annots.push(e),t}(o,t,n,a,i):"trackIndex"===e[3]&&1!==i.numAvailTracks?[o,r]=function(t,e,n,r,o,a){var i=bi[a.numAvailTracks-1];return t.trackIndex=e[3],t.trackIndexOriginal=e[4],t.color="#"+i[t.trackIndexOriginal],t.trackIndex>a.config.numTracks-1?(t.trackIndex in n?n[t.trackIndex].push(t):n[t.trackIndex]=[t],[r,n]):(r[o].annots.push(t),[r,n])}(t,n,r,o,a,i):o=function(t,e,n,r){return e.trackIndex=0,e.color||(e.color=r.config.annotationsColor),e.shape||(e.shape="triangle"),t[n].annots.push(e),t}(o,t,a,i),[o,r]}function Si(t,e,n,r,o,a,i){var c,s,l,u;for(c=0;c<n.annots.length;c++){for(u=n.annots[c],l={},s=0;s<a.length;s++)l[a[s]]=u[s];l.stop=l.start+l.length,l.chr=n.chr,l.chrIndex=o,l.startPx=i.convertBpToPx(r,l.start),l.stopPx=i.convertBpToPx(r,l.stop),l.px=Math.round((l.startPx+l.stopPx)/2),[t,e]=yi(l,a,u,e,t,o,i)}return[t,e]}function Ci(t){console.warn('Chromosome "'+t.chr+'" undefined in ideogram; '+t.annots.length+" annotations not shown")}function xi(t){var e,n,r;return e=t.keys,t=t.annots,[n,r]=function(t,e,n){var r,o,a,i,c=[],s={};for(r=-1,o=0;o<t.length;o++)a=t[o],void 0!==(i=n.chromosomes[n.config.taxid][a.chr])?(r++,c.push({chr:a.chr,annots:[]}),"heatmap-2d"!==n.config.annotationsLayout?[c,s]=Si(c,s,a,i,r,e,n):[c,s]=Ha(c,s,a,i,r,e,n)):Ci(a);return[c,s]}(t,e,this),n=function(t,e){var n,r,o,a,i,c;for(n=t,t=[],c=e.chromosomesArray,r=0;r<c.length;r++)for(i=c[r].name,o=0;o<n.length;o++)(a=n[o]).chr===i&&t.push(a);return t}(n,this),function(t,e){var n,r=e.config.annotationsLayout,o=e.config.numAnnotTracks;!/heatmap/.test(r)&&o>10&&console.error("Ideogram only displays up to 10 tracks at a time. You specified "+o+" tracks. Perhaps consider a different way to visualize your data."),(n=Object.keys(t).length)&&console.warn("Ideogram configuration specified "+o+" tracks, but loaded annotations contain "+n+" extra tracks.")}(r,this),n}class _i{constructor(t,e){this.matrix=t,this.ideo=e}setRawAnnots(){var t,e,n;return t=this,e=this.ideo,n=this.matrix,new Promise((function(r){t.rawAnnots=t.fetchCoordinates(e).then((function(o){t.coordinates=o,r(t.parseExpressionMatrix(n,e))}))}))}fetchCoordinates(t){var e={};if("human"===t.config.organism){var n=t.config.dataDir+"../../annotations/Homo_sapiens,_Ensembl_80.tsv";return new Promise((function(r){t.fetch(n,"text").then((function(t){var n,o,a,i,c,s,l,u;for(n=t.split(/\r\n|\n/).slice(1),o=0;o<n.length;o++)[a,i,c,u,s]=n[o].split(/\s/g),a=parseInt(a),l=(i=parseInt(i))-a,e[c]=[s,a,l];r(e)}))}))}throw Error("Expression matrix parsing is only supported for human")}parseAnnotFromTsvLine(t,e){var n,r,o,a,i,c=t.split(/\s/g);return(a=c[0])in this.coordinates==!1?[null,null]:(i=c.slice(1).map(t=>parseFloat(t)),[r,o,length]=this.coordinates[a],-1===(n=e.indexOf(r))?[null,null]:[n,[a,o,length].concat(i)])}parseExpressionMatrix(t,e){var n,r,o,a,i,c,s=[],l=t.split(/\r\n|\n/);for(r=Object.keys(e.chromosomes[e.config.taxid]),n=0;n<r.length;n++)s.push({chr:r[n],annots:[]});for(n=1;n<l.length;n++)a=l[n],[i,c]=this.parseAnnotFromTsvLine(a,r),null!==i&&s[i].annots.push(c);return o=l[0].split(/\s/g),{keys:["name","start","length"].concat(o),annots:s}}}function wi(){const t=this,e={};t.annots.forEach(n=>{n.annots.forEach(n=>{const r=t.annotDescriptions.annots[n.name];e[n.name]=[n.name,r.ensemblId,n.chr,n.start,n.stop,n.length,r.type]})});const n=[["# Gene name","Ensembl ID","Chromosome","Start","Stop","Length","Type"]].concat(Object.values(e)),r=t.annotDescriptions.headers+"\n#\n"+n.map(t=>t.join("\t")).join("\n"),o="data:text/plain;charset=utf-8,"+encodeURIComponent(r);var a=new MouseEvent("click",{view:window,bubbles:!1,cancelable:!0}),i=document.createElement("a");i.setAttribute("download","ideogram.tsv"),i.setAttribute("href",o),i.setAttribute("target","_blank"),i.setAttribute("id","_ideo-undisplayed-dl-annots-link"),i.setAttribute("style","display: none;"),document.body.appendChild(i),i.dispatchEvent(a)}function zi(){var t=this.config;!function(t){var e,n=t.config;n.annotationHeight||("heatmap"===n.annotationsLayout?e=n.chrWidth-1:(e=Math.round(n.chrHeight/100))<3&&(e=3),t.config.annotationHeight=e)}(this),t.annotationsPath||t.localAnnotationsPath||this.annots||t.annotations?function(t,e){e.annotationTracks?t.config.numAnnotTracks=e.annotationTracks.length:e.annotationsNumTracks?t.config.numAnnotTracks=e.annotationsNumTracks:t.config.numAnnotTracks=1,t.config.annotTracksHeight=e.annotationHeight*e.numAnnotTracks,void 0===e.barWidth&&(t.config.barWidth=3)}(this,t):(this.config.annotTracksHeight=0,this.config.numAnnotTracks=0),void 0===t.annotationsColor&&(this.config.annotationsColor="#F00"),t.onClickAnnot&&(this.onClickAnnotCallback=t.onClickAnnot),function(t,e){!1!==e.showAnnotTooltip&&(t.config.showAnnotTooltip=!0),e.onWillShowAnnotTooltip&&(t.onWillShowAnnotTooltipCallback=e.onWillShowAnnotTooltip)}(this,t)}function Ei(){var t=this.config;this.rawAnnots.annots=this.rawAnnots.annots.sort((function(t,e){return t.chr.localeCompare(e.chr,"en",{numeric:!0})})),this.onLoadAnnotsCallback&&this.onLoadAnnotsCallback(),("heatmapThresholds"in t||"metadata"in this.rawAnnots&&"heatmapThresholds"in this.rawAnnots.metadata)&&("heatmap"===t.annotationsLayout?function(t){var e,n,r,o,a,i,c=t.config.heatmapThresholds;for(r=[],n=(a=t.rawAnnots).keys.slice(3),o=[],i=[],!a.metadata&&isNaN(c[0])||(c=Ga(t)),e=0;e<n.length;e++)r.push({key:n[e],thresholds:c}),o.push({id:n[e]}),i.push(e+1);t.config.annotationsNumTracks=n.length,t.config.annotationsDisplayedTracks=i,t.config.heatmaps=r,t.config.annotationTracks=o}(this):"heatmap-2d"===t.annotationsLayout&&(this.config.heatmapThresholds=Ga(this))),t.heatmaps&&this.deserializeAnnotsForHeatmap(this.rawAnnots)}function Mi(t){var e,n,r=this,o=r.config;n="heatmap-2d"===o.annotationsLayout,"http"===t.slice(0,4)||n?(e=n?"":function(t){var e,n;return"bed"!==(n=(e=t.split("?")[0].split("."))[e.length-1])&&"json"!==n?(n=n.toUpperCase(),void alert("Ideogram.js only supports BED and Ideogram JSON at the moment. Sorry, check back soon for "+n+" support!")):n}(t),r.fetch(t,"text").then((function(t){(r.rawAnnotsResponse=t,n)?new _i(t,r).setRawAnnots().then((function(t){r.rawAnnots=t,r.afterRawAnnots()})):(r.rawAnnots="bed"===e?new Ea(t,r).rawAnnots:JSON.parse(t),r.afterRawAnnots())}))):r.fetch(t).then((function(t){r.rawAnnotsResponse=t,r.rawAnnots=t,r.afterRawAnnots()}))}function qi(t){var e,n,r,o,a,i,c;for(e=[],n=[],r=this.chromosomesArray,o=0;o<r.length;o++)a=r[o].name,n.push(a),e.push({chr:a,annots:[]});for(o=0;o<t.length;o++)i=t[o],-1!==(c=n.indexOf(i.chr))&&(e[c]=i);return e}function ki(t,e="red"){const n=this,r=n.config.taxid,o=t.map(t=>{const o=n.chromosomes[r][t].id,a=`${n.selector} #${o}-chromosome-set`,i=document.querySelector(a),c=i.getBoundingClientRect();return`<rect class="ideo-highlight" ${`id="ideo-highlight-${o}"`} ${`style="\n stroke-width: 1px;\n stroke: ${e};\n fill: ${e};\n fill-opacity: 0.05;\n position: absolute;\n rx: 4;\n ry: 4;\n height: ${c.width+15}px;\n width: 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Promise((function(n){e.coordinateSystem="bp",e.getAssemblyAndChromosomesFromEutils(t,n)}));n=e.config.dataDir,r=Po(e.organisms[t].scientificName),o=[t],["9606","10090","10116"].includes(t)&&!e.config.showFullyBanded&&(r+="-no-bands");var a=n+r+".json";return new Promise((function(t,e){fetch(a).then((function(n){if(!1!==n.ok)return n.json().then((function(e){t(e.chrBands)}));e(Error("Fetch failed for "+a))}))})).then((function(n){var r,a,i,c,s=[""],l=[],u={};e.bandData[t]=n;for(var p=0;p<n.length;p++)r=(i=n[p].split(" "))[0],c=i.slice(-1)[0],r in u||(l.push({name:r,type:"nuclear",length:c}),u[r]=1);return l=l.sort(Ideogram.sortChromosomes),a={bp:0,iscn:0},l.forEach(t=>{t.length>a.bp&&(a.bp=t.length)}),e.maxLength[t]=a,s.push(l),s.push(o),s}),(function(){return new Promise((function(n){e.coordinateSystem="bp",e.getAssemblyAndChromosomesFromEutils(t,n)}))}))})(t,n).then((function(l){r=l[0],o=l[1],"chromosomes"in s==!1||null===s.chromosomes?(n.config.chromosomes={},n.config.chromosomes[t]=o):(s.multiorganism?t in s.chromosomes?a=s.chromosomes[t]:(i=Po(n.getScientificName(t)),n.config.chromosomes[t]=s.chromosomes[i].slice(),a=n.config.chromosomes[t]):a=s.chromosomes,c=o.filter(t=>a.includes(t.name)),n.config.chromosomes[t]=c),n.chromosomes[t]=n.config.chromosomes[t].slice(),n.organisms[t].assemblies={default:r},e()}))}function Ai(t,e){var n,r;for(n in e.organisms)if(r=e.organisms[n],n===Po(t)||Po(r.commonName)===Po(t)||Po(r.scientificName)===Po(t))return!0;return!1}function Ri(t){var e,n,r,o,a,i=t.config;return e=[],n={},function(t,e){var n,r,o,a=[],i={};for(o=0;o<t.length;o++)r=!1===Ai(n=t[o],e)?Li(n,e).then((function(t){var n,r,o=t[1];r=(n=t[0].replace("-"," "))[0].toUpperCase()+n.slice(1),i[o]={scientificName:r,commonName:"",assemblies:{default:""}},Object.assign(e.organisms,i)})):new Promise((function(t){var r=e.getTaxid(n);i[r]=e.organisms[r],t()})),a.push(r);return Promise.all(a).then((function(){return i}))}(i.multiorganism?i.organism:[i.organism],t).then((function(t){var c=t[o];for(o in t)c=t[o],e.push(o),i.multiorganism&&(void 0!==i.chromosomes?((a=Object.keys(i.chromosomes).map(t=>Po(t))).includes(Po(c.scientificName))?r=c.scientificName:a.includes(Po(c.commonName))&&(r=c.commonName),Po(r)in i.chromosomes?n[o]=i.chromosomes[Po(r)]:n[o]=i.chromosomes[r.toLowerCase()]):n=null);return[n,e]}))}function Fi(t,e){Ri(e).then((function([n,r]){var o,a,i,c,s,l=e.config,u=[];for(o=0;o<r.length;o++)a=r[o],c=e.organisms[a].assemblies,s=Object.values(c),""===c.default||e.assemblyIsAccession()&&!s.includes(l.assembly)?i=new Promise((function(t){Ti(a,t,e)})):(e.config.taxids=r,e.config.multiorganism&&(e.config.chromosomes=n),i=new Promise((function(t){t()}))),u.push(i);Promise.all(u).then((function(){return r=function(t){var e,n,r;if(e=t.config.organism,n=[],Array.isArray(e))for(r=0;r<e.length;r++)n.push(t.getTaxid(e[r]));else n.push(t.getTaxid(e));return n}(e),e.config.taxids=r,t(r)}))}))}function Ii(t){var e;if(e="taxid"in this.config,this.config.multiorganism=function(t,e){return"organism"in e.config&&e.config.organism instanceof Array||t&&e.config.taxid instanceof Array}(e,this),this.config.multiorganism&&(this.coordinateSystem="bp"),"organism"in this.config){const e=this.config.organism;"string"==typeof e&&(this.config.organism=Po(e.toLowerCase())),Fi(t,this)}else!function(t,e,n){var r;n.config.multiorganism?t&&(r=n.config.taxid):(t&&(r=[n.config.taxid]),n.config.taxids=r),e(r)}(e,t,this)}function Hi(t,e){var n,r;return[n,r]=function(t,e){var n=t.genome;return"mitochondrion"===n?function(t,e){var n,r;return e.config.showNonNuclearChromosomes?(n=t.genome,[-1===(r=t.subtype.split("|").indexOf("plasmid"))?"MT":t.subname.split("|")[r],n]):[null,null]}(t,e):"chloroplast"===n||"plastid"===n?function(t){return t.config.showNonNuclearChromosomes?["CP","chloroplast"]:[null,null]}(e):"apicoplast"===n?function(t){return t.config.showNonNuclearChromosomes?["AP","apicoplast"]:[null,null]}(e):function(t){var e,n;return"nuclear",e=t.subtype.split("|").indexOf("chromosome"),void 0!==(n=t.subname.split("|")[e])&&"chr"===n.substr(0,3)&&(n=n.substr(3)),[n,"nuclear"]}(t)}(t,e),{name:n,length:t.slen,type:r}}function Di(t,e){var n,r=this,o=function(t,e){var n;return n=e.assemblyIsAccession()?e.config.assembly+"%22[Assembly%20Accession]":t+"%22[taxid]AND%20(%22latest%20refseq%22[filter])%20",e.esearch+"&db=assembly&term=%22"+n+"AND%20(%22chromosome%20level%22[filter]%20OR%20%22complete%20genome%22[filter])"}(t,r);To.json(o).then((function(t){return function(t,e){var n,r;return n=t.esearchresult.idlist[0],r=e.esummary+"&db=assembly&id="+n,To.json(r)}(t,r)})).then((function(t){var e=t.result.uids[0];return n=t.result[e],function(t,e){var n;return n="&db=nuccore&dbfrom=assembly&linkname=assembly_nuccore&cmd=neighbor_history&from_uid="+t,To.json(e.elink+n).then((function(t){var r=t.linksets[0].webenv;return n="&db=nuccore&term=%231+AND+%28sequence_from_chromosome[Properties]+OR+sequence_from_plastid[Properties]+OR+sequence_from_mitochondrion[Properties]%29&WebEnv="+r+"&usehistory=y&retmax=1000",e.esearch+n}))}(e,r)})).then((function(t){return To.json(t)})).then((function(t){return function(t,e){var n,r;return n=t.esearchresult.idlist.join(","),r=e.esummary+"&db=nucleotide&id="+n,To.json(r)}(t,r)})).then((function(o){var a=function(t,e,n){var r,o,a,i,c={},s=[];for(r in t)"uids"!==r&&(a=(o=Hi(t[r],n)).name+"_"+o.length,null!==o.type&&a in c==!1&&s.push(o),c[a]=1);return s=s.sort(Ideogram.sortChromosomes),i={bp:0,iscn:0},s.forEach(t=>{t.length>i.bp&&(i.bp=t.length)}),i.bp>n.maxLength.bp&&(n.maxLength.bp=i.bp),n.maxLength[e]=i,n.coordinateSystem="bp",s}(o.result,t,r);return e([n,a])}),(function(t){console.warn(t)}))}function Bi(){var t=this.bandsToShow.join(",");0!==this.bandsToShow.length&&(To.selectAll(this.selector+" .bandLabel, 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e=a.getChromosomeBandLabelTranslate(t,i);return"horizontal"===o.config.orientation?r[n.id].push(e.x+13):r[n.id].push(e.y+6),e.translate})).append("text").attr("text-anchor",a.getChromosomeBandLabelAnchor(i)).text((function(t){return t.name})),r}function Wi(t,e,n,r){var o=this;t.selectAll("line.bandLabelStalk").data(e).enter().append("g").attr("class",(function(t,e){return"bandLabelStalk bsbsl-"+e})).attr("transform",(function(t){var e;return e=o.round(t.px.start+t.px.width/2),-10,r[n.id].push(e+13),"translate("+e+","+-10+")"})).append("line").attr("x1",0).attr("y1",o._layout.getChromosomeBandTickY1(n.chrIndex)).attr("x2",0).attr("y2",o._layout.getChromosomeBandTickY2(n.chrIndex))}function Qi(t){var e,n,r,o,a,i={};for(o=function(t){var e,n,r=[];for(e in t)for(n in t[e])r.push(t[e][n]);return r}(t),e=0;e<o.length;e++)r=o[e],n=To.select(this.selector+" 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i,c,s;i=a.convertBpToPx(t,e)+r,c=a.convertBpToPx(t,n)+r,s=a._layout.getChromosomeSetYTranslate(0)+(a.config.chrWidth-o)/2,To.select(a.selector).append("g").attr("class","brush").attr("transform","translate(0, "+s+")").call(a.brush).call(a.brush.move,[i,c])}(r,e,n,s,c,this)}function oc(){call(this.onCursorMoveCallback)}function ac(t){var e,n,r,o=this.config.chrWidth+6.5,a=this._layout.margin.left;if(void 0===t)return!1;e=function(t,e){var n,r;for(n=0;n<e.chromosomesArray.length;n++)if((r=e.chromosomesArray[n]).name===t)return r}(this.config.chromosome,this),[n,r]=function(t,e){var n,r,o=[1],a=[1],i=t.bands.slice(-1)[0];for(r=0;r<t.bands.length;r++)n=t.bands[r],o.push(n.bp.start),a.push(n.px.start+e);return o.push(i.bp.stop-1),a.push(i.px.stop+e),[o,a]}(e,a),function(t,e,n,r,o,a){var i;i=To.scaleLinear().domain(e).range(n),"rotatable"in a.config&&!1===a.config.rotatable||console.warn("Using the cursor with rotate is not supported.");var 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right">&blacktriangleright;</span></li>\n <li id="about-tool">About</li>\n </ul>\n </div>'),os(t),function(t){const e=document.querySelector(t.selector),n=document.querySelector("#gear"),r=document.querySelector("#tools");e.addEventListener("mouseover",()=>n.style.display=""),e.addEventListener("mouseout",()=>{"none"===r.style.display&&(n.style.display="none")}),n.addEventListener("mouseover",()=>n.style.display="")}(t)}class is{constructor(t){this._model=t,this._class="ModelAdapter"}static getInstance(t){return t.bands?new is(t):new cs(t)}getModel(){return this._model}getCssClass(){return""}}class cs extends is{constructor(t){super(t),this._class="ModelNoBandsAdapter"}getModel(){this._model.bands=[];const t="MT"===this._model.name,e=this._model.width;return(e>1||t)&&this._model.bands.push({name:"q",px:{start:0,stop:e,width:e},bp:{start:1,stop:this._model.bpLength},iscn:{start:1,stop:this._model.length}}),this._model}getCssClass(){return"noBands"}}class ss{constructor(t){this._config=t,this._ploidy=new ra(this._config)}getArmColor(t,e,n){return this._config.armColors?this._config.armColors[n]:this._config.ancestors?this._getPolyploidArmColor(t,e,n):null}getBorderColor(t,e,n){const r=this._config,o=r.chrBorderColor?r.chrBorderColor:"#000";return e<r.ploidy||this._ploidy.exists(t,e,n)?o:"#fff"}_getPolyploidArmColor(t,e,n){if(this._ploidy.exists(t,e,n)){var r=this._ploidy.getAncestor(t,e,n);return this._config.ancestors[r]}return"transparent"}}class ls{constructor(t){this._data=t,this.start=t.start,this.stop=t.stop,this.length=this.stop-this.start}getColor(t){return"ploidy"in this._data?"ploidy"in this._data&&this._data.ploidy[t]?this._getColor(t):"transparent":this._getColor(t)}_getColor(t){return Array.isArray(this._data.color)?this._data.color[t]:this._data.color}}class us{constructor(t,e,n){this._adapter=t,this._model=this._adapter.getModel(),this._config=e,this._ideo=n,this._color=new ss(this._config),this._bumpCoefficient=5}static getInstance(t,e,n){const r=t.getModel().centromerePosition;return"telocentric-p"===r?new ds(t,e,n):"telocentric-q"===r?new hs(t,e,n):new ps(t,e,n)}_addPArmShape(t,e){return e?t.concat(this._getPArmShape()):t}_addQArmShape(t,e){return e?t.concat(this._getQArmShape()):t}render(t,e,n){var r,o,a,i,c,s,l;return r=this,t=t.append("g").attr("class","bands").attr("clip-path","url(#"+this._model.id+"-chromosome-set-clippath)"),o=this._renderArm(t,e,n,"p"),a=this._renderArm(t,e,n,"q"),this._renderRangeSet(t,e,n),i=[],i=this._addPArmShape(i,o),i=this._addQArmShape(i,a),c="0",s="",l=this.isFullyBanded(),"ancestors"in this._ideo.config&&!("rangeSet"in this._ideo.config)?(s=r._color.getArmColor(e,n,0),l&&(c="0.5")):l?(c=null,s="transparent"):"ancestors"in this._ideo.config||(c="1"),t.append("g").attr("class","chromosome-border").selectAll("path").data(i).enter().append("path").attr("fill",s).style("fill-opacity",c).attr("stroke",(function(t,o){return r._color.getBorderColor(e,n,o)})).attr("stroke-width",(function(t){return"strokeWidth"in t?t.strokeWidth:1})).attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),i}_renderRangeSet(t,e,n){var r,o,a,i;"rangeSet"in this._config&&(o=this._config.rangeSet.filter((function(t){return t.chr-1===e})).map((function(t){return new ls(t)})),a=t.append("g").attr("class","range-set"),i=(r=this)._ideo,a.selectAll("rect.range").data(o).enter().append("rect").attr("class","range").attr("x",(function(t){return i.convertBpToPx(r._model,t.start)})).attr("y",0).attr("width",(function(t){return i.convertBpToPx(r._model,t.length)})).attr("height",this._config.chrWidth).style("fill",(function(t){return t.getColor(n)})))}_getShapeData(){var t,e,n,r;for(e=0;e<this._model.bands.length;e++)if("q"===this._model.bands[e].name[0]){t=this._model.bands[e];break}return n=this._model.bands.length-1,r=this._model.bands[n].px.stop,{x1:0,x2:t?t.px.start:r,x3:r,w:this._config.chrWidth,b:this._config.chrWidth/this._bumpCoefficient}}_getPArmShape(){var t=this._getShapeData(),e=t.x2-t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+t.b+",0 L"+e+",0 Q"+(t.x2+t.b)+","+t.w/2+","+e+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}:[{class:"",path:"M"+t.b+",0 L"+(e-2)+",0 L"+(e-2)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"},{class:"acen",path:"M"+e+",0 Q"+(t.x2+t.b)+","+t.w/2+","+e+","+t.w+" L"+e+","+t.w+" L"+(e-2)+","+t.w+" L"+(e-2)+",0"}]}_getQArmShape(){var t=this._getShapeData(),e=t.x3-t.b,n=t.x2+t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+n+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+n+","+t.w+" Q"+(t.x2-t.b)+","+t.w/2+","+n+",0"}:[{path:"M"+n+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+n+","+t.w+" L"+n+",0"},{class:"acen",path:"M"+n+",0Q"+(t.x2-t.b)+","+t.w/2+","+n+","+t.w+" L"+n+","+t.w+"L"+(n+2)+","+t.w+"L"+(n+2)+",0"}]}isFullyBanded(){return this._model.bands&&(2!==this._model.bands.length||"q"===this._model.bands[0].name[0])}_renderBands(t,e,n,r,o){var a,i,c;i="p"===o?0:1,c="","ancestors"in(a=this)._ideo.config&&!a.isFullyBanded()&&(c=a._color.getArmColor(e,n,i)),t.selectAll("path.band."+o).data(r).enter().append("path").attr("id",(function(t){return a._model.id+"-"+t.name.replace(".","-")})).attr("class",(function(t){return"band "+o+"-band "+t.stain})).attr("d",(function(t){var e;return"M "+a._ideo.round(t.px.start)+", 0l "+(e=a._ideo.round(t.px.width))+" 0 l 0 "+a._config.chrWidth+" l -"+e+" 0 z"})).style("fill",c)}_renderArm(t,e,n,r){var o=this._model.bands.filter((function(t){return t.name[0]===r}));return this._renderBands(t,e,n,o,r),Boolean(o.length)}}class ps extends us{constructor(t,e,n){super(t,e,n),this._class="MetacentricChromosome"}}class ds extends us{constructor(t,e,n){super(t,e,n),this._class="TelocentricPChromosome",this._pArmOffset=3}_addPArmShape(t){return t.concat(this._getPArmShape())}_getPArmShape(){var t=this._getShapeData();return t.o=this._pArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2-t.o+5)+",0L"+(t.x2-t.o+3)+",0 L"+(t.x2-t.o+3)+","+t.w+" L"+(t.x2-t.o+5)+","+t.w,strokeWidth:.5}]}_getQArmShape(){var t=this._getShapeData(),e=t.x3-t.b,n=this._pArmOffset+3;return{class:"",path:"M"+(t.x2+n)+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+(t.x2+n)+","+t.w}}}class hs extends us{constructor(t,e,n){super(t,e,n),this._class="TelocentricQChromosome",this._qArmOffset=3}_getPArmShape(){var t=this._getShapeData(),e=t.x3-t.b,n=this._qArmOffset;return{class:"",path:"M"+(t.x2+n)+",0 L"+(e+n)+",0 L"+(e+n)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}}_addQArmShape(t){return t.concat(this._getQArmShape())}_getQArmShape(){var t=this._getShapeData();return t.o=this._qArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1 L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2+t.o+5)+",0 L"+(t.x2+t.o+3)+",0 L"+(t.x2+t.o+3)+","+t.w+" L"+(t.x2+t.o+5)+","+t.w,strokeWidth:.5}]}}function fs(t,e,n,r){var o,a,i,c,s;c=To.select(this.selector+" defs"),s=is.getInstance(t),o=n*this.config.chrMargin,a=r.append("g").attr("id",t.id).attr("class","chromosome "+s.getCssClass()).attr("transform","translate(0, "+o+")"),i=us.getInstance(s,this.config,this).render(a,e,n),To.select("#"+t.id+"-chromosome-set-clippath").remove(),c.append("clipPath").attr("id",t.id+"-chromosome-set-clippath").selectAll("path").data(i).enter().append("path").attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),t.width<1&&To.select("#"+t.id+" .bands").style("opacity",0)}function ms(t){var e,n,r,o,a,i;if(e=t.chrIndex,o=this._layout.getChromosomeSetTranslate(e),i=this.selector+" #"+t.id+"-chromosome-set",To.selectAll(i+" g").remove(),0===(n=To.select(i)).nodes().length&&(n=To.select(this.selector).append("g").attr("class","chromosome-set").attr("transform",o).attr("id",t.id+"-chromosome-set")),"sex"in this.config&&2===this.config.ploidy&&this.sexChromosomes.index===e)this.drawSexChromosomes(n,e);else for(r=1,this.config.ploidy>1&&(r=this._ploidy.getChromosomesNumber(e)),a=0;a<r;a++)this.appendHomolog(t,e,a,n)}function gs(t){var e,n;this.unhighlight(),this.config.taxid&&(e=t.id.split("-")[0].replace("chr",""),n=this.chromosomes[this.config.taxid][e].chrIndex,this._layout.rotate(n,n,t))}function vs(){var t,e,n,r,o,a,i;t=this.config,o=To.select(t.container+" svg#_ideogram"),n=To.select(t.container+" #_ideogramInnerWrap"),r=To.select(t.container+" #_ideogramMiddleWrap"),i=1===(a=t.ploidy)?a:1.12*a;let c=0;"annotationsLayout"in t&&(c=t.annotationHeight*t.numAnnotTracks),"vertical"===t.orientation&&"comparative"!==t.perspective&&"collinear"!==t.geometry&&(e=this.numChromosomes*(t.chrWidth+t.chrMargin+c),"heatmap-2d"!==t.annotationsLayout&&(e=Math.ceil(e*i/t.rows),"SmallLayout"===this._layout._class&&(e+=100),e+=35,r.style("height",this._layout.getHeight()+"px"),n.style("max-width",e+"px").style("overflow-x","scroll").style("position","absolute"),o.style("min-width",e-5+"px"),this.config.showTools&&as(this)))}function bs(t){var e=t._layout;To.selectAll(t.selector+" .chromosome-set").insert("text",":first-child").data(t.chromosomesArray).attr("class",e.getChromosomeLabelClass()).attr("transform",e.getChromosomeSetLabelTranslate()).attr("x",e.getChromosomeSetLabelXPosition()).attr("y",(function(t,n){return e.getChromosomeSetLabelYPosition(n)})).attr("text-anchor",e.getChromosomeSetLabelAnchor()).each((function(e,n){!function(t,e,n,r){var o=function(t,e,n){var r;return r=-1===t.name.indexOf(" 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function ws(t,e){const n=`&format=condensed&type=paralogues&target_taxon=${e.config.taxid}`,r=`/homology/id/${t.id}?${n}`,o=(await Ideogram.fetchEnsembl(r)).data[0].homologies;return await async function(t,e){const n=[],r=`?q=${t.map(t=>`ensemblgene:${t.id}`).join(" OR ")}&species=${e.config.taxid}&fields=symbol,genomic_pos,name`;return(await Cs(r)).hits.forEach(t=>{if("genomic_pos"in t==!1)return;if("name"in t==!1)return;const r=zs(t,e,"pink");n.push(r);const o=t.name,{name:a,ensemblId:i}=xs(t),c={description:o,ensemblId:i,name:a,type:"paralogous gene"};e.annotDescriptions.annots[r.name]=c}),n}(o,e)}function zs(t,e,n="red"){let r=null;return r=Array.isArray(t.genomic_pos)?t.genomic_pos.filter(t=>t.chr in e.chromosomes[e.config.taxid])[0]:t.genomic_pos,{name:t.symbol,chr:r.chr,start:r.start,stop:r.end,id:r.ensemblgene,color:n}}function Es(t,e,n){return new Promise(async r=>{const o=await async function(t,e){const n={},r={},o=e.config.organism.replace(/-/g," 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i=document.querySelector("#_ideogramInnerWrap");if(i.style.position="relative",i.style.marginLeft="auto",i.style.marginRight="auto",i.style.overflowY="hidden",document.querySelector("#_ideogramMiddleWrap").style.overflowY="hidden",void 0===e.didAdjustIdeogramLegend){var c=document.querySelector("#_ideogram");const t=140;i.style.maxWidth=parseInt(i.style.maxWidth)+t+"px",c.style.maxWidth=parseInt(c.style.minWidth)+"px",c.style.position="relative",c.style.left=t+"px",e.didAdjustIdeogramLegend=!0}const s=`?q=symbol:${t}&species=${e.config.taxid}&fields=symbol,genomic_pos,name`,l=(await Cs(s)).hits[0],u=l.name,p=l.genomic_pos.ensemblgene;e.annotDescriptions.annots[l.symbol]={description:u,ensemblId:p,name:u,type:"searched gene"},e.relatedAnnots=[];const d=zs(l,e);e.relatedAnnots.push(d),await Promise.all([Es(d,i,e),Ms(d,i,e)]),e.timeRelatedGenes=Math.round(performance.now()-n),function(t){const e=t.annotDescriptions.annots,n=Object.keys(e).length,r=Object.values(e),o=r.filter(t=>"paralogous gene"===t.type).length,a=r.filter(t=>"interacting gene"===t.type).length,i=Object.entries(e).filter(t=>"searched gene"===t[1].type)[0][0],c=t.timeRelatedGenes;t.relatedGenesAnalytics={searchedGene:i,numRelatedGenes:n,numParalogs:o,numInteractingGenes:a,time:c}}(e),e.onPlotRelatedGenesCallback&&e.onPlotRelatedGenesCallback()}function Gs(t){const e=this.annotDescriptions.annots[t.name].description.split(" [")[0];return t.displayName=`<span id="ideo-related-gene" style="color: #0366d6; cursor: pointer;">${t.name}</span>\n <br/>\n ${e}\n <br/>`,function(t){const e=document.querySelector("._ideogramTooltip");t.addedTooltipClickHandler||(e.addEventListener("click",()=>{const e=function(t,e){var n;return e.annots.forEach(e=>{e.annots.forEach(e=>{t===e.name&&(n=e)})}),n}(document.querySelector("#ideo-related-gene").textContent,t);t.onClickAnnot(e)}),t.addedTooltipClickHandler=!0)}(this),t}const Ls=[{name:'\n <div style="position: relative; left: -15px; padding-bottom: 10px;">\n <div style="font-size: 14px; font-weight: bold; font-color: #333">Related genes</div>\n <i>Click gene to search</i>\n </div>\n ',nameHeight:30,rows:[{name:"Interacting gene",color:"purple",shape:"triangle"},{name:"Paralogous gene",color:"pink",shape:"triangle"},{name:"Searched gene",color:"red",shape:"triangle"}]}];class 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l(this,e),f(this,m(e).apply(this,arguments))}return v(e,t),p(e,[{key:"render",value:function(){var t=this.props,e=t.isEnabled,n=o(t,["isEnabled"]);return e?y.a.createElement(ge,n):this.props.children}}]),e}(b.Component);c(ve,"defaultProps",{isEnabled:!0});var be=function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n=e.isSearchable,r=e.isMulti,o=e.label,a=e.isDisabled;switch(t){case"menu":return"Use Up and Down to choose options".concat(a?"":", press Enter to select the currently focused option",", press Escape to exit the menu, press Tab to select the option and exit the menu.");case"input":return"".concat(o||"Select"," is focused ").concat(n?",type to refine list":"",", press Down to open the menu, ").concat(r?" press left to focus selected values":"");case"value":return"Use left and right to toggle between focused values, press Backspace to remove the currently focused value"}},ye=function(t,e){var n=e.value,r=e.isDisabled;if(n)switch(t){case"deselect-option":case"pop-value":case"remove-value":return"option ".concat(n,", deselected.");case"select-option":return"option ".concat(n,r?" is disabled. Select another option.":", selected.")}},Se=function(t){return!!t.isDisabled},Ce={clearIndicator:Dt,container:function(t){var e=t.isDisabled;return{label:"container",direction:t.isRtl?"rtl":null,pointerEvents:e?"none":null,position:"relative"}},control:function(t){var e=t.isDisabled,n=t.isFocused,r=t.theme,o=r.colors,a=r.borderRadius,i=r.spacing;return{label:"control",alignItems:"center",backgroundColor:e?o.neutral5:o.neutral0,borderColor:e?o.neutral10:n?o.primary:o.neutral20,borderRadius:a,borderStyle:"solid",borderWidth:1,boxShadow:n?"0 0 0 1px ".concat(o.primary):null,cursor:"default",display:"flex",flexWrap:"wrap",justifyContent:"space-between",minHeight:i.controlHeight,outline:"0 !important",position:"relative",transition:"all 100ms","&:hover":{borderColor:n?o.primary:o.neutral30}}},dropdownIndicator:Ht,group:function(t){var e=t.theme.spacing;return{paddingBottom:2*e.baseUnit,paddingTop:2*e.baseUnit}},groupHeading:function(t){var e=t.theme.spacing;return{label:"group",color:"#999",cursor:"default",display:"block",fontSize:"75%",fontWeight:"500",marginBottom:"0.25em",paddingLeft:3*e.baseUnit,paddingRight:3*e.baseUnit,textTransform:"uppercase"}},indicatorsContainer:function(){return{alignItems:"center",alignSelf:"stretch",display:"flex",flexShrink:0}},indicatorSeparator:function(t){var e=t.isDisabled,n=t.theme,r=n.spacing.baseUnit,o=n.colors;return{label:"indicatorSeparator",alignSelf:"stretch",backgroundColor:e?o.neutral10:o.neutral20,marginBottom:2*r,marginTop:2*r,width:1}},input:function(t){var e=t.isDisabled,n=t.theme,r=n.spacing,o=n.colors;return{margin:r.baseUnit/2,paddingBottom:r.baseUnit/2,paddingTop:r.baseUnit/2,visibility:e?"hidden":"visible",color:o.neutral80}},loadingIndicator:function(t){var e=t.isFocused,n=t.size,r=t.theme,o=r.colors,a=r.spacing.baseUnit;return{label:"loadingIndicator",color:e?o.neutral60:o.neutral20,display:"flex",padding:2*a,transition:"color 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e=t.theme,n=e.spacing,r=e.borderRadius;return{label:"multiValue",backgroundColor:e.colors.neutral10,borderRadius:r/2,display:"flex",margin:n.baseUnit/2,minWidth:0}},multiValueLabel:function(t){var e=t.theme,n=e.borderRadius,r=e.colors,o=t.cropWithEllipsis;return{borderRadius:n/2,color:r.neutral80,fontSize:"85%",overflow:"hidden",padding:3,paddingLeft:6,textOverflow:o?"ellipsis":null,whiteSpace:"nowrap"}},multiValueRemove:function(t){var e=t.theme,n=e.spacing,r=e.borderRadius,o=e.colors;return{alignItems:"center",borderRadius:r/2,backgroundColor:t.isFocused&&o.dangerLight,display:"flex",paddingLeft:n.baseUnit,paddingRight:n.baseUnit,":hover":{backgroundColor:o.dangerLight,color:o.danger}}},noOptionsMessage:xt,option:function(t){var e=t.isDisabled,n=t.isFocused,r=t.isSelected,o=t.theme,a=o.spacing,i=o.colors;return{label:"option",backgroundColor:r?i.primary:n?i.primary25:"transparent",color:e?i.neutral20:r?i.neutral0:"inherit",cursor:"default",display:"block",fontSize:"inherit",padding:"".concat(2*a.baseUnit,"px ").concat(3*a.baseUnit,"px"),width:"100%",userSelect:"none",WebkitTapHighlightColor:"rgba(0, 0, 0, 0)",":active":{backgroundColor:!e&&(r?i.primary:i.primary50)}}},placeholder:function(t){var e=t.theme,n=e.spacing;return{label:"placeholder",color:e.colors.neutral50,marginLeft:n.baseUnit/2,marginRight:n.baseUnit/2,position:"absolute",top:"50%",transform:"translateY(-50%)"}},singleValue:function(t){var e=t.isDisabled,n=t.theme,r=n.spacing,o=n.colors;return{label:"singleValue",color:e?o.neutral40:o.neutral80,marginLeft:r.baseUnit/2,marginRight:r.baseUnit/2,maxWidth:"calc(100% - ".concat(2*r.baseUnit,"px)"),overflow:"hidden",position:"absolute",textOverflow:"ellipsis",whiteSpace:"nowrap",top:"50%",transform:"translateY(-50%)"}},valueContainer:function(t){var e=t.theme.spacing;return{alignItems:"center",display:"flex",flex:1,flexWrap:"wrap",padding:"".concat(e.baseUnit/2,"px ").concat(2*e.baseUnit,"px"),WebkitOverflowScrolling:"touch",position:"relative",overflow:"hidden"}}};function xe(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n=s({},t);return Object.keys(e).forEach((function(r){t[r]?n[r]=function(n,o){return e[r](t[r](n,o),o)}:n[r]=e[r]})),n}var _e={borderRadius:4,colors:{primary:"#2684FF",primary75:"#4C9AFF",primary50:"#B2D4FF",primary25:"#DEEBFF",danger:"#DE350B",dangerLight:"#FFBDAD",neutral0:"hsl(0, 0%, 100%)",neutral5:"hsl(0, 0%, 95%)",neutral10:"hsl(0, 0%, 90%)",neutral20:"hsl(0, 0%, 80%)",neutral30:"hsl(0, 0%, 70%)",neutral40:"hsl(0, 0%, 60%)",neutral50:"hsl(0, 0%, 50%)",neutral60:"hsl(0, 0%, 40%)",neutral70:"hsl(0, 0%, 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e=n.props,r=e.blurInputOnSelect,o=e.isMulti,a=n.state.selectValue;if(o)if(n.isOptionSelected(t,a)){var c=n.getOptionValue(t);n.setValue(a.filter((function(t){return n.getOptionValue(t)!==c})),"deselect-option",t),n.announceAriaLiveSelection({event:"deselect-option",context:{value:n.getOptionLabel(t)}})}else n.isOptionDisabled(t,a)?n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t),isDisabled:!0}}):(n.setValue([].concat(i(a),[t]),"select-option",t),n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t)}}));else n.isOptionDisabled(t,a)?n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t),isDisabled:!0}}):(n.setValue(t,"select-option"),n.announceAriaLiveSelection({event:"select-option",context:{value:n.getOptionLabel(t)}}));r&&n.blurInput()})),c(h(h(n)),"removeValue",(function(t){var e=n.state.selectValue,r=n.getOptionValue(t),o=e.filter((function(t){return 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e=n.props,r=e.isMulti,o=e.menuIsOpen;n.focusInput(),o?(n.inputIsHiddenAfterUpdate=!r,n.onMenuClose()):n.openMenu("first"),t.preventDefault(),t.stopPropagation()}})),c(h(h(n)),"onClearIndicatorMouseDown",(function(t){t&&"mousedown"===t.type&&0!==t.button||(n.clearValue(),t.stopPropagation(),n.openAfterFocus=!1,"touchend"===t.type?n.focusInput():setTimeout((function(){return n.focusInput()})))})),c(h(h(n)),"onScroll",(function(t){"boolean"==typeof n.props.closeMenuOnScroll?t.target instanceof HTMLElement&&ut(t.target)&&n.props.onMenuClose():"function"==typeof n.props.closeMenuOnScroll&&n.props.closeMenuOnScroll(t)&&n.props.onMenuClose()})),c(h(h(n)),"onCompositionStart",(function(){n.isComposing=!0})),c(h(h(n)),"onCompositionEnd",(function(){n.isComposing=!1})),c(h(h(n)),"onTouchStart",(function(t){var e=t.touches.item(0);e&&(n.initialTouchX=e.clientX,n.initialTouchY=e.clientY,n.userIsDragging=!1)})),c(h(h(n)),"onTouchMove",(function(t){var e=t.touches.item(0);if(e){var 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e=n.props,r=e.isSearchable,o=e.isMulti;n.props.onFocus&&n.props.onFocus(t),n.inputIsHiddenAfterUpdate=!1,n.announceAriaLiveContext({event:"input",context:{isSearchable:r,isMulti:o}}),n.setState({isFocused:!0}),(n.openAfterFocus||n.props.openMenuOnFocus)&&n.openMenu("first"),n.openAfterFocus=!1})),c(h(h(n)),"onInputBlur",(function(t){n.menuListRef&&n.menuListRef.contains(document.activeElement)?n.inputRef.focus():(n.props.onBlur&&n.props.onBlur(t),n.onInputChange("",{action:"input-blur"}),n.onMenuClose(),n.setState({focusedValue:null,isFocused:!1}))})),c(h(h(n)),"onOptionHover",(function(t){n.blockOptionHover||n.state.focusedOption===t||n.setState({focusedOption:t})})),c(h(h(n)),"shouldHideSelectedOptions",(function(){var t=n.props,e=t.hideSelectedOptions,r=t.isMulti;return void 0===e?r:e})),c(h(h(n)),"onKeyDown",(function(t){var e=n.props,r=e.isMulti,o=e.backspaceRemovesValue,a=e.escapeClearsValue,i=e.inputValue,c=e.isClearable,s=e.isDisabled,l=e.menuIsOpen,u=e.onKeyDown,p=e.tabSelectsValue,d=e.openMenuOnFocus,h=n.state,f=h.focusedOption,m=h.focusedValue,g=h.selectValue;if(!(s||"function"==typeof u&&(u(t),t.defaultPrevented))){switch(n.blockOptionHover=!0,t.key){case"ArrowLeft":if(!r||i)return;n.focusValue("previous");break;case"ArrowRight":if(!r||i)return;n.focusValue("next");break;case"Delete":case"Backspace":if(i)return;if(m)n.removeValue(m);else{if(!o)return;r?n.popValue():c&&n.clearValue()}break;case"Tab":if(n.isComposing)return;if(t.shiftKey||!l||!p||!f||d&&n.isOptionSelected(f,g))return;n.selectOption(f);break;case"Enter":if(229===t.keyCode)break;if(l){if(!f)return;if(n.isComposing)return;n.selectOption(f);break}return;case"Escape":l?(n.inputIsHiddenAfterUpdate=!1,n.onInputChange("",{action:"menu-close"}),n.onMenuClose()):c&&a&&n.clearValue();break;case" ":if(i)return;if(!l){n.openMenu("first");break}if(!f)return;n.selectOption(f);break;case"ArrowUp":l?n.focusOption("up"):n.openMenu("last");break;case"ArrowDown":l?n.focusOption("down"):n.openMenu("first");break;case"PageUp":if(!l)return;n.focusOption("pageup");break;case"PageDown":if(!l)return;n.focusOption("pagedown");break;case"Home":if(!l)return;n.focusOption("first");break;case"End":if(!l)return;n.focusOption("last");break;default:return}t.preventDefault()}}));var r=t.value;n.cacheComponents=C(n.cacheComponents,Gt).bind(h(h(n))),n.cacheComponents(t.components),n.instancePrefix="react-select-"+(n.props.instanceId||++ze);var o=lt(r),a=t.menuIsOpen?n.buildMenuOptions(t,o):{render:[],focusable:[]};return n.state.menuOptions=a,n.state.selectValue=o,n}return v(e,t),p(e,[{key:"componentDidMount",value:function(){this.startListeningComposition(),this.startListeningToTouch(),this.props.closeMenuOnScroll&&document&&document.addEventListener&&document.addEventListener("scroll",this.onScroll,!0),this.props.autoFocus&&this.focusInput()}},{key:"UNSAFE_componentWillReceiveProps",value:function(t){var e=this.props,n=e.options,r=e.value,o=e.menuIsOpen,a=e.inputValue;if(this.cacheComponents(t.components),t.value!==r||t.options!==n||t.menuIsOpen!==o||t.inputValue!==a){var i=lt(t.value),c=t.menuIsOpen?this.buildMenuOptions(t,i):{render:[],focusable:[]},s=this.getNextFocusedValue(i),l=this.getNextFocusedOption(c.focusable);this.setState({menuOptions:c,selectValue:i,focusedOption:l,focusedValue:s})}null!=this.inputIsHiddenAfterUpdate&&(this.setState({inputIsHidden:this.inputIsHiddenAfterUpdate}),delete this.inputIsHiddenAfterUpdate)}},{key:"componentDidUpdate",value:function(t){var e,n,r,o,a,i=this.props,c=i.isDisabled,s=i.menuIsOpen,l=this.state.isFocused;(l&&!c&&t.isDisabled||l&&s&&!t.menuIsOpen)&&this.focusInput(),this.menuListRef&&this.focusedOptionRef&&this.scrollToFocusedOptionOnUpdate&&(e=this.menuListRef,n=this.focusedOptionRef,r=e.getBoundingClientRect(),o=n.getBoundingClientRect(),a=n.offsetHeight/3,o.bottom+a>r.bottom?dt(e,Math.min(n.offsetTop+n.clientHeight-e.offsetHeight+a,e.scrollHeight)):o.top-a<r.top&&dt(e,Math.max(n.offsetTop-a,0))),this.scrollToFocusedOptionOnUpdate=!1}},{key:"componentWillUnmount",value:function(){this.stopListeningComposition(),this.stopListeningToTouch(),document.removeEventListener("scroll",this.onScroll,!0)}},{key:"onMenuOpen",value:function(){this.props.onMenuOpen()}},{key:"onMenuClose",value:function(){var t=this.props,e=t.isSearchable,n=t.isMulti;this.announceAriaLiveContext({event:"input",context:{isSearchable:e,isMulti:n}}),this.onInputChange("",{action:"menu-close"}),this.props.onMenuClose()}},{key:"onInputChange",value:function(t,e){this.props.onInputChange(t,e)}},{key:"focusInput",value:function(){this.inputRef&&this.inputRef.focus()}},{key:"blurInput",value:function(){this.inputRef&&this.inputRef.blur()}},{key:"openMenu",value:function(t){var e=this.state,n=e.menuOptions,r=e.selectValue,o=e.isFocused,a=this.props.isMulti,i="first"===t?0:n.focusable.length-1;if(!a){var c=n.focusable.indexOf(r[0]);c>-1&&(i=c)}this.scrollToFocusedOptionOnUpdate=!(o&&this.menuListRef),this.inputIsHiddenAfterUpdate=!1,this.onMenuOpen(),this.setState({focusedValue:null,focusedOption:n.focusable[i]}),this.announceAriaLiveContext({event:"menu"})}},{key:"focusValue",value:function(t){var e=this.props,n=e.isMulti,r=e.isSearchable,o=this.state,a=o.selectValue,i=o.focusedValue;if(n){this.setState({focusedOption:null});var c=a.indexOf(i);i||(c=-1,this.announceAriaLiveContext({event:"value"}));var s=a.length-1,l=-1;if(a.length){switch(t){case"previous":l=0===c?0:-1===c?s:c-1;break;case"next":c>-1&&c<s&&(l=c+1)}-1===l&&this.announceAriaLiveContext({event:"input",context:{isSearchable:r,isMulti:n}}),this.setState({inputIsHidden:-1!==l,focusedValue:a[l]})}}}},{key:"focusOption",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:"first",e=this.props.pageSize,n=this.state,r=n.focusedOption,o=n.menuOptions,a=o.focusable;if(a.length){var 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e=this.options.fetchPolicy;this.options=Object(r.a)(Object(r.a)({},this.options),t),t.pollInterval?this.startPolling(t.pollInterval):0===t.pollInterval&&this.stopPolling();var n=t.fetchPolicy;return this.setVariables(this.options.variables,e!==n&&("cache-only"===e||"standby"===e||"network-only"===n),t.fetchResults)},e.prototype.setVariables=function(t,e,n){return void 0===e&&(e=!1),void 0===n&&(n=!0),this.isTornDown=!1,t=t||this.variables,!e&&Object(a.a)(t,this.variables)?this.observers.size&&n?this.result():Promise.resolve():(this.variables=this.options.variables=t,this.observers.size?this.queryManager.fetchQuery(this.queryId,this.options):Promise.resolve())},e.prototype.updateQuery=function(t){var e=this.queryManager,n=e.getQueryWithPreviousResult(this.queryId),r=n.previousResult,a=n.variables,i=n.document,c=Object(o.I)((function(){return 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t=this,e=this.queryManager,n=this.queryId;this.shouldSubscribe&&e.addObservableQuery(n,this),this.options.pollInterval&&(R(this),e.startPollingQuery(this.options,n));var o=function(e){t.updateLastResult(Object(r.a)(Object(r.a)({},t.lastResult),{errors:e.graphQLErrors,networkStatus:_.error,loading:!1})),A(t.observers,"error",t.lastError=e)};e.observeQuery(n,this.options,{next:function(n){if(t.lastError||t.isDifferentFromLastResult(n)){var r=t.updateLastResult(n),o=t.options,i=o.query,c=o.variables,s=o.fetchPolicy;e.transform(i).hasClientExports?e.getLocalState().addExportedVariables(i,c).then((function(o){var c=t.variables;t.variables=t.options.variables=o,!n.loading&&r&&"cache-only"!==s&&e.transform(i).serverQuery&&!Object(a.a)(c,o)?t.refetch():A(t.observers,"next",n)})):A(t.observers,"next",n)}},error:o}).catch(o)},e.prototype.tearDownQuery=function(){var t=this.queryManager;this.isTornDown=!0,t.stopPollingQuery(this.queryId),this.subscriptions.forEach((function(t){return 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this.store[t]},t.prototype.initQuery=function(t){var e=this.store[t.queryId];Object(s.b)(!e||e.document===t.document||Object(a.a)(e.document,t.document),19);var n,r=!1,o=null;t.storePreviousVariables&&e&&e.networkStatus!==_.loading&&(Object(a.a)(e.variables,t.variables)||(r=!0,o=e.variables)),n=r?_.setVariables:t.isPoll?_.poll:t.isRefetch?_.refetch:_.loading;var i=[];e&&e.graphQLErrors&&(i=e.graphQLErrors),this.store[t.queryId]={document:t.document,variables:t.variables,previousVariables:o,networkError:null,graphQLErrors:i,networkStatus:n,metadata:t.metadata},"string"==typeof t.fetchMoreForQueryId&&this.store[t.fetchMoreForQueryId]&&(this.store[t.fetchMoreForQueryId].networkStatus=_.fetchMore)},t.prototype.markQueryResult=function(t,e,n){this.store&&this.store[t]&&(this.store[t].networkError=null,this.store[t].graphQLErrors=q(e.errors)?e.errors:[],this.store[t].previousVariables=null,this.store[t].networkStatus=_.ready,"string"==typeof n&&this.store[n]&&(this.store[n].networkStatus=_.ready))},t.prototype.markQueryError=function(t,e,n){this.store&&this.store[t]&&(this.store[t].networkError=e,this.store[t].networkStatus=_.error,"string"==typeof n&&this.markQueryResultClient(n,!0))},t.prototype.markQueryResultClient=function(t,e){var n=this.store&&this.store[t];n&&(n.networkError=null,n.previousVariables=null,e&&(n.networkStatus=_.ready))},t.prototype.stopQuery=function(t){delete this.store[t]},t.prototype.reset=function(t){var e=this;Object.keys(this.store).forEach((function(n){t.indexOf(n)<0?e.stopQuery(n):e.store[n].networkStatus=_.loading}))},t}();var H=function(){function t(t){var e=t.cache,n=t.client,r=t.resolvers,o=t.fragmentMatcher;this.cache=e,n&&(this.client=n),r&&this.addResolvers(r),o&&this.setFragmentMatcher(o)}return t.prototype.addResolvers=function(t){var e=this;this.resolvers=this.resolvers||{},Array.isArray(t)?t.forEach((function(t){e.resolvers=Object(o.A)(e.resolvers,t)})):this.resolvers=Object(o.A)(this.resolvers,t)},t.prototype.setResolvers=function(t){this.resolvers={},this.addResolvers(t)},t.prototype.getResolvers=function(){return this.resolvers||{}},t.prototype.runResolvers=function(t){var e=t.document,n=t.remoteResult,o=t.context,a=t.variables,i=t.onlyRunForcedResolvers,c=void 0!==i&&i;return Object(r.b)(this,void 0,void 0,(function(){return Object(r.d)(this,(function(t){return e?[2,this.resolveDocument(e,n.data,o,a,this.fragmentMatcher,c).then((function(t){return Object(r.a)(Object(r.a)({},n),{data:t.result})}))]:[2,n]}))}))},t.prototype.setFragmentMatcher=function(t){this.fragmentMatcher=t},t.prototype.getFragmentMatcher=function(){return this.fragmentMatcher},t.prototype.clientQuery=function(t){return Object(o.s)(["client"],t)&&this.resolvers?t:null},t.prototype.serverQuery=function(t){return this.resolvers?Object(o.C)(t):t},t.prototype.prepareContext=function(t){void 0===t&&(t={});var e=this.cache;return Object(r.a)(Object(r.a)({},t),{cache:e,getCacheKey:function(t){if(e.config)return e.config.dataIdFromObject(t);Object(s.b)(!1,6)}})},t.prototype.addExportedVariables=function(t,e,n){return void 0===e&&(e={}),void 0===n&&(n={}),Object(r.b)(this,void 0,void 0,(function(){return Object(r.d)(this,(function(o){return t?[2,this.resolveDocument(t,this.buildRootValueFromCache(t,e)||{},this.prepareContext(n),e).then((function(t){return Object(r.a)(Object(r.a)({},e),t.exportedVariables)}))]:[2,Object(r.a)({},e)]}))}))},t.prototype.shouldForceResolvers=function(t){var e=!1;return Object(z.visit)(t,{Directive:{enter:function(t){if("client"===t.name.value&&t.arguments&&(e=t.arguments.some((function(t){return"always"===t.name.value&&"BooleanValue"===t.value.kind&&!0===t.value.value}))))return z.BREAK}}}),e},t.prototype.buildRootValueFromCache=function(t,e){return this.cache.diff({query:Object(o.d)(t),variables:e,returnPartialData:!0,optimistic:!1}).result},t.prototype.resolveDocument=function(t,e,n,a,i,c){return void 0===n&&(n={}),void 0===a&&(a={}),void 0===i&&(i=function(){return!0}),void 0===c&&(c=!1),Object(r.b)(this,void 0,void 0,(function(){var s,l,u,p,d,h,f,m,g;return Object(r.d)(this,(function(v){var b;return s=Object(o.l)(t),l=Object(o.j)(t),u=Object(o.g)(l),p=s.operation,d=p?(b=p).charAt(0).toUpperCase()+b.slice(1):"Query",f=(h=this).cache,m=h.client,g={fragmentMap:u,context:Object(r.a)(Object(r.a)({},n),{cache:f,client:m}),variables:a,fragmentMatcher:i,defaultOperationType:d,exportedVariables:{},onlyRunForcedResolvers:c},[2,this.resolveSelectionSet(s.selectionSet,e,g).then((function(t){return{result:t,exportedVariables:g.exportedVariables}}))]}))}))},t.prototype.resolveSelectionSet=function(t,e,n){return Object(r.b)(this,void 0,void 0,(function(){var a,i,c,l,u,p=this;return Object(r.d)(this,(function(d){return a=n.fragmentMap,i=n.context,c=n.variables,l=[e],u=function(t){return Object(r.b)(p,void 0,void 0,(function(){var u,p;return Object(r.d)(this,(function(r){return Object(o.F)(t,c)?Object(o.t)(t)?[2,this.resolveField(t,e,n).then((function(e){var n;void 0!==e&&l.push(((n={})[Object(o.E)(t)]=e,n))}))]:(Object(o.v)(t)?u=t:(u=a[t.name.value],Object(s.b)(u,7)),u&&u.typeCondition&&(p=u.typeCondition.name.value,n.fragmentMatcher(e,p,i))?[2,this.resolveSelectionSet(u.selectionSet,e,n).then((function(t){l.push(t)}))]:[2]):[2]}))}))},[2,Promise.all(t.selections.map(u)).then((function(){return Object(o.B)(l)}))]}))}))},t.prototype.resolveField=function(t,e,n){return Object(r.b)(this,void 0,void 0,(function(){var a,i,c,s,l,u,p,d,h,f=this;return Object(r.d)(this,(function(r){return a=n.variables,i=t.name.value,c=Object(o.E)(t),s=i!==c,l=e[c]||e[i],u=Promise.resolve(l),n.onlyRunForcedResolvers&&!this.shouldForceResolvers(t)||(p=e.__typename||n.defaultOperationType,(d=this.resolvers&&this.resolvers[p])&&(h=d[s?i:c])&&(u=Promise.resolve(h(e,Object(o.b)(t,a),n.context,{field:t,fragmentMap:n.fragmentMap})))),[2,u.then((function(e){return void 0===e&&(e=l),t.directives&&t.directives.forEach((function(t){"export"===t.name.value&&t.arguments&&t.arguments.forEach((function(t){"as"===t.name.value&&"StringValue"===t.value.kind&&(n.exportedVariables[t.value.value]=e)}))})),t.selectionSet?null==e?e:Array.isArray(e)?f.resolveSubSelectedArray(t,e,n):t.selectionSet?f.resolveSelectionSet(t.selectionSet,e,n):void 0:e}))]}))}))},t.prototype.resolveSubSelectedArray=function(t,e,n){var r=this;return Promise.all(e.map((function(e){return null===e?null:Array.isArray(e)?r.resolveSubSelectedArray(t,e,n):t.selectionSet?r.resolveSelectionSet(t.selectionSet,e,n):void 0})))},t}();function D(t){var e=new Set,n=null;return new M((function(r){return e.add(r),n=n||t.subscribe({next:function(t){e.forEach((function(e){return e.next&&e.next(t)}))},error:function(t){e.forEach((function(e){return e.error&&e.error(t)}))},complete:function(){e.forEach((function(t){return t.complete&&t.complete()}))}}),function(){e.delete(r)&&!e.size&&n&&(n.unsubscribe(),n=null)}}))}var B=Object.prototype.hasOwnProperty,V=function(){function t(t){var e=t.link,n=t.queryDeduplication,r=void 0!==n&&n,a=t.store,i=t.onBroadcast,c=void 0===i?function(){}:i,s=t.ssrMode,l=void 0!==s&&s,u=t.clientAwareness,p=void 0===u?{}:u,d=t.localState,h=t.assumeImmutableResults;this.mutationStore=new F,this.queryStore=new I,this.clientAwareness={},this.idCounter=1,this.queries=new Map,this.fetchQueryRejectFns=new Map,this.transformCache=new(o.e?WeakMap:Map),this.inFlightLinkObservables=new Map,this.pollingInfoByQueryId=new Map,this.link=e,this.queryDeduplication=r,this.dataStore=a,this.onBroadcast=c,this.clientAwareness=p,this.localState=d||new H({cache:a.getCache()}),this.ssrMode=l,this.assumeImmutableResults=!!h}return t.prototype.stop=function(){var t=this;this.queries.forEach((function(e,n){t.stopQueryNoBroadcast(n)})),this.fetchQueryRejectFns.forEach((function(t){t(new s.a(8))}))},t.prototype.mutate=function(t){var e=t.mutation,n=t.variables,a=t.optimisticResponse,i=t.updateQueries,c=t.refetchQueries,l=void 0===c?[]:c,u=t.awaitRefetchQueries,p=void 0!==u&&u,d=t.update,h=t.errorPolicy,f=void 0===h?"none":h,m=t.fetchPolicy,g=t.context,v=void 0===g?{}:g;return Object(r.b)(this,void 0,void 0,(function(){var t,c,u,h=this;return Object(r.d)(this,(function(g){switch(g.label){case 0:return Object(s.b)(e,9),Object(s.b)(!m||"no-cache"===m,10),t=this.generateQueryId(),e=this.transform(e).document,this.setQuery(t,(function(){return{document:e}})),n=this.getVariables(e,n),this.transform(e).hasClientExports?[4,this.localState.addExportedVariables(e,n,v)]:[3,2];case 1:n=g.sent(),g.label=2;case 2:return c=function(){var t={};return i&&h.queries.forEach((function(e,n){var r=e.observableQuery;if(r){var o=r.queryName;o&&B.call(i,o)&&(t[n]={updater:i[o],query:h.queryStore.get(n)})}})),t},this.mutationStore.initMutation(t,e,n),this.dataStore.markMutationInit({mutationId:t,document:e,variables:n,updateQueries:c(),update:d,optimisticResponse:a}),this.broadcastQueries(),u=this,[2,new Promise((function(i,s){var h,g;u.getObservableFromLink(e,Object(r.a)(Object(r.a)({},v),{optimisticResponse:a}),n,!1).subscribe({next:function(r){Object(o.q)(r)&&"none"===f?g=new L({graphQLErrors:r.errors}):(u.mutationStore.markMutationResult(t),"no-cache"!==m&&u.dataStore.markMutationResult({mutationId:t,result:r,document:e,variables:n,updateQueries:c(),update:d}),h=r)},error:function(e){u.mutationStore.markMutationError(t,e),u.dataStore.markMutationComplete({mutationId:t,optimisticResponse:a}),u.broadcastQueries(),u.setQuery(t,(function(){return{document:null}})),s(new L({networkError:e}))},complete:function(){if(g&&u.mutationStore.markMutationError(t,g),u.dataStore.markMutationComplete({mutationId:t,optimisticResponse:a}),u.broadcastQueries(),g)s(g);else{"function"==typeof l&&(l=l(h));var e=[];q(l)&&l.forEach((function(t){if("string"==typeof t)u.queries.forEach((function(n){var r=n.observableQuery;r&&r.queryName===t&&e.push(r.refetch())}));else{var n={query:t.query,variables:t.variables,fetchPolicy:"network-only"};t.context&&(n.context=t.context),e.push(u.query(n))}})),Promise.all(p?e:[]).then((function(){u.setQuery(t,(function(){return{document:null}})),"ignore"===f&&h&&Object(o.q)(h)&&delete h.errors,i(h)}))}}})}))]}}))}))},t.prototype.fetchQuery=function(t,e,n,a){return Object(r.b)(this,void 0,void 0,(function(){var i,c,s,l,u,p,d,h,f,m,g,v,b,y,S,C,x,_,w=this;return Object(r.d)(this,(function(z){switch(z.label){case 0:return i=e.metadata,c=void 0===i?null:i,s=e.fetchPolicy,l=void 0===s?"cache-first":s,u=e.context,p=void 0===u?{}:u,d=this.transform(e.query).document,h=this.getVariables(d,e.variables),this.transform(d).hasClientExports?[4,this.localState.addExportedVariables(d,h,p)]:[3,2];case 1:h=z.sent(),z.label=2;case 2:if(e=Object(r.a)(Object(r.a)({},e),{variables:h}),g=m="network-only"===l||"no-cache"===l,m||(v=this.dataStore.getCache().diff({query:d,variables:h,returnPartialData:!0,optimistic:!1}),b=v.complete,y=v.result,g=!b||"cache-and-network"===l,f=y),S=g&&"cache-only"!==l&&"standby"!==l,Object(o.s)(["live"],d)&&(S=!0),C=this.idCounter++,x="no-cache"!==l?this.updateQueryWatch(t,d,e):void 0,this.setQuery(t,(function(){return{document:d,lastRequestId:C,invalidated:!0,cancel:x}})),this.invalidate(a),this.queryStore.initQuery({queryId:t,document:d,storePreviousVariables:S,variables:h,isPoll:n===G.poll,isRefetch:n===G.refetch,metadata:c,fetchMoreForQueryId:a}),this.broadcastQueries(),S){if(_=this.fetchRequest({requestId:C,queryId:t,document:d,options:e,fetchMoreForQueryId:a}).catch((function(e){throw k(e)?e:(C>=w.getQuery(t).lastRequestId&&(w.queryStore.markQueryError(t,e,a),w.invalidate(t),w.invalidate(a),w.broadcastQueries()),new L({networkError:e}))})),"cache-and-network"!==l)return[2,_];_.catch((function(){}))}return this.queryStore.markQueryResultClient(t,!S),this.invalidate(t),this.invalidate(a),this.transform(d).hasForcedResolvers?[2,this.localState.runResolvers({document:d,remoteResult:{data:f},context:p,variables:h,onlyRunForcedResolvers:!0}).then((function(n){return w.markQueryResult(t,n,e,a),w.broadcastQueries(),n}))]:(this.broadcastQueries(),[2,{data:f}])}}))}))},t.prototype.markQueryResult=function(t,e,n,r){var o=n.fetchPolicy,a=n.variables,i=n.errorPolicy;"no-cache"===o?this.setQuery(t,(function(){return{newData:{result:e.data,complete:!0}}})):this.dataStore.markQueryResult(e,this.getQuery(t).document,a,r,"ignore"===i||"all"===i)},t.prototype.queryListenerForObserver=function(t,e,n){var r=this;function o(t,e){if(n[t])try{n[t](e)}catch(t){}}return function(n,a){if(r.invalidate(t,!1),n){var i=r.getQuery(t),c=i.observableQuery,s=i.document,l=c?c.options.fetchPolicy:e.fetchPolicy;if("standby"!==l){var u=E(n.networkStatus),p=c&&c.getLastResult(),d=!(!p||p.networkStatus===n.networkStatus),h=e.returnPartialData||!a&&n.previousVariables||d&&e.notifyOnNetworkStatusChange||"cache-only"===l||"cache-and-network"===l;if(!u||h){var f=q(n.graphQLErrors),m=c&&c.options.errorPolicy||e.errorPolicy||"none";if("none"===m&&f||n.networkError)return o("error",new L({graphQLErrors:n.graphQLErrors,networkError:n.networkError}));try{var g=void 0,v=void 0;if(a)"no-cache"!==l&&"network-only"!==l&&r.setQuery(t,(function(){return{newData:null}})),g=a.result,v=!a.complete;else{var b=c&&c.getLastError(),y="none"!==m&&(b&&b.graphQLErrors)!==n.graphQLErrors;if(p&&p.data&&!y)g=p.data,v=!1;else{var S=r.dataStore.getCache().diff({query:s,variables:n.previousVariables||n.variables,returnPartialData:!0,optimistic:!0});g=S.result,v=!S.complete}}var C=v&&!(e.returnPartialData||"cache-only"===l),x={data:C?p&&p.data:g,loading:u,networkStatus:n.networkStatus,stale:C};"all"===m&&f&&(x.errors=n.graphQLErrors),o("next",x)}catch(t){o("error",new L({networkError:t}))}}}}}},t.prototype.transform=function(t){var e=this.transformCache;if(!e.has(t)){var n=this.dataStore.getCache(),r=n.transformDocument(t),a=Object(o.D)(n.transformForLink(r)),i=this.localState.clientQuery(r),c=this.localState.serverQuery(a),s={document:r,hasClientExports:Object(o.r)(r),hasForcedResolvers:this.localState.shouldForceResolvers(r),clientQuery:i,serverQuery:c,defaultVars:Object(o.h)(Object(o.m)(r))},l=function(t){t&&!e.has(t)&&e.set(t,s)};l(t),l(r),l(i),l(c)}return e.get(t)},t.prototype.getVariables=function(t,e){return Object(r.a)(Object(r.a)({},this.transform(t).defaultVars),e)},t.prototype.watchQuery=function(t,e){void 0===e&&(e=!0),Object(s.b)("standby"!==t.fetchPolicy,11),t.variables=this.getVariables(t.query,t.variables),void 0===t.notifyOnNetworkStatusChange&&(t.notifyOnNetworkStatusChange=!1);var n=Object(r.a)({},t);return new O({queryManager:this,options:n,shouldSubscribe:e})},t.prototype.query=function(t){var e=this;return Object(s.b)(t.query,12),Object(s.b)("Document"===t.query.kind,13),Object(s.b)(!t.returnPartialData,14),Object(s.b)(!t.pollInterval,15),new Promise((function(n,r){var o=e.watchQuery(t,!1);e.fetchQueryRejectFns.set("query:"+o.queryId,r),o.result().then(n,r).then((function(){return e.fetchQueryRejectFns.delete("query:"+o.queryId)}))}))},t.prototype.generateQueryId=function(){return String(this.idCounter++)},t.prototype.stopQueryInStore=function(t){this.stopQueryInStoreNoBroadcast(t),this.broadcastQueries()},t.prototype.stopQueryInStoreNoBroadcast=function(t){this.stopPollingQuery(t),this.queryStore.stopQuery(t),this.invalidate(t)},t.prototype.addQueryListener=function(t,e){this.setQuery(t,(function(t){return t.listeners.add(e),{invalidated:!1}}))},t.prototype.updateQueryWatch=function(t,e,n){var r=this,o=this.getQuery(t).cancel;o&&o();return this.dataStore.getCache().watch({query:e,variables:n.variables,optimistic:!0,previousResult:function(){var e=null,n=r.getQuery(t).observableQuery;if(n){var o=n.getLastResult();o&&(e=o.data)}return e},callback:function(e){r.setQuery(t,(function(){return{invalidated:!0,newData:e}}))}})},t.prototype.addObservableQuery=function(t,e){this.setQuery(t,(function(){return{observableQuery:e}}))},t.prototype.removeObservableQuery=function(t){var e=this.getQuery(t).cancel;this.setQuery(t,(function(){return{observableQuery:null}})),e&&e()},t.prototype.clearStore=function(){this.fetchQueryRejectFns.forEach((function(t){t(new s.a(16))}));var t=[];return this.queries.forEach((function(e,n){e.observableQuery&&t.push(n)})),this.queryStore.reset(t),this.mutationStore.reset(),this.dataStore.reset()},t.prototype.resetStore=function(){var t=this;return this.clearStore().then((function(){return t.reFetchObservableQueries()}))},t.prototype.reFetchObservableQueries=function(t){var e=this;void 0===t&&(t=!1);var n=[];return this.queries.forEach((function(r,o){var a=r.observableQuery;if(a){var i=a.options.fetchPolicy;a.resetLastResults(),"cache-only"===i||!t&&"standby"===i||n.push(a.refetch()),e.setQuery(o,(function(){return{newData:null}})),e.invalidate(o)}})),this.broadcastQueries(),Promise.all(n)},t.prototype.observeQuery=function(t,e,n){return this.addQueryListener(t,this.queryListenerForObserver(t,e,n)),this.fetchQuery(t,e)},t.prototype.startQuery=function(t,e,n){return this.addQueryListener(t,n),this.fetchQuery(t,e).catch((function(){})),t},t.prototype.startGraphQLSubscription=function(t){var e=this,n=t.query,r=t.fetchPolicy,a=t.variables;n=this.transform(n).document,a=this.getVariables(n,a);var i=function(t){return e.getObservableFromLink(n,{},t,!1).map((function(a){if(r&&"no-cache"===r||(e.dataStore.markSubscriptionResult(a,n,t),e.broadcastQueries()),Object(o.q)(a))throw new L({graphQLErrors:a.errors});return a}))};if(this.transform(n).hasClientExports){var c=this.localState.addExportedVariables(n,a).then(i);return new M((function(t){var e=null;return c.then((function(n){return e=n.subscribe(t)}),t.error),function(){return e&&e.unsubscribe()}}))}return i(a)},t.prototype.stopQuery=function(t){this.stopQueryNoBroadcast(t),this.broadcastQueries()},t.prototype.stopQueryNoBroadcast=function(t){this.stopQueryInStoreNoBroadcast(t),this.removeQuery(t)},t.prototype.removeQuery=function(t){this.fetchQueryRejectFns.delete("query:"+t),this.fetchQueryRejectFns.delete("fetchRequest:"+t),this.getQuery(t).subscriptions.forEach((function(t){return t.unsubscribe()})),this.queries.delete(t)},t.prototype.getCurrentQueryResult=function(t,e){void 0===e&&(e=!0);var n=t.options,r=n.variables,o=n.query,a=n.fetchPolicy,i=n.returnPartialData,c=t.getLastResult(),s=this.getQuery(t.queryId).newData;if(s&&s.complete)return{data:s.result,partial:!1};if("no-cache"===a||"network-only"===a)return{data:void 0,partial:!1};var l=this.dataStore.getCache().diff({query:o,variables:r,previousResult:c?c.data:void 0,returnPartialData:!0,optimistic:e}),u=l.result,p=l.complete;return{data:p||i?u:void 0,partial:!p}},t.prototype.getQueryWithPreviousResult=function(t){var e;if("string"==typeof t){var n=this.getQuery(t).observableQuery;Object(s.b)(n,17),e=n}else e=t;var r=e.options,o=r.variables,a=r.query;return{previousResult:this.getCurrentQueryResult(e,!1).data,variables:o,document:a}},t.prototype.broadcastQueries=function(){var t=this;this.onBroadcast(),this.queries.forEach((function(e,n){e.invalidated&&e.listeners.forEach((function(r){r&&r(t.queryStore.get(n),e.newData)}))}))},t.prototype.getLocalState=function(){return this.localState},t.prototype.getObservableFromLink=function(t,e,n,a){var i,c=this;void 0===a&&(a=this.queryDeduplication);var s=this.transform(t).serverQuery;if(s){var l=this.inFlightLinkObservables,u=this.link,p={query:s,variables:n,operationName:Object(o.n)(s)||void 0,context:this.prepareContext(Object(r.a)(Object(r.a)({},e),{forceFetch:!a}))};if(e=p.context,a){var d=l.get(s)||new Map;l.set(s,d);var h=JSON.stringify(n);if(!(i=d.get(h))){d.set(h,i=D(x(u,p)));var f=function(){d.delete(h),d.size||l.delete(s),m.unsubscribe()},m=i.subscribe({next:f,error:f,complete:f})}}else i=D(x(u,p))}else i=M.of({data:{}}),e=this.prepareContext(e);var g=this.transform(t).clientQuery;return g&&(i=function(t,e){return new M((function(n){var r=n.next,o=n.error,a=n.complete,i=0,c=!1,s={next:function(t){++i,new Promise((function(n){n(e(t))})).then((function(t){--i,r&&r.call(n,t),c&&s.complete()}),(function(t){--i,o&&o.call(n,t)}))},error:function(t){o&&o.call(n,t)},complete:function(){c=!0,i||a&&a.call(n)}},l=t.subscribe(s);return function(){return l.unsubscribe()}}))}(i,(function(t){return c.localState.runResolvers({document:g,remoteResult:t,context:e,variables:n})}))),i},t.prototype.fetchRequest=function(t){var e,n,r=this,o=t.requestId,a=t.queryId,i=t.document,c=t.options,s=t.fetchMoreForQueryId,l=c.variables,u=c.errorPolicy,p=void 0===u?"none":u,d=c.fetchPolicy;return new Promise((function(t,u){var h=r.getObservableFromLink(i,c.context,l),f="fetchRequest:"+a;r.fetchQueryRejectFns.set(f,u);var m=function(){r.fetchQueryRejectFns.delete(f),r.setQuery(a,(function(t){t.subscriptions.delete(g)}))},g=h.map((function(t){if(o>=r.getQuery(a).lastRequestId&&(r.markQueryResult(a,t,c,s),r.queryStore.markQueryResult(a,t,s),r.invalidate(a),r.invalidate(s),r.broadcastQueries()),"none"===p&&q(t.errors))return u(new L({graphQLErrors:t.errors}));if("all"===p&&(n=t.errors),s||"no-cache"===d)e=t.data;else{var h=r.dataStore.getCache().diff({variables:l,query:i,optimistic:!1,returnPartialData:!0}),f=h.result;(h.complete||c.returnPartialData)&&(e=f)}})).subscribe({error:function(t){m(),u(t)},complete:function(){m(),t({data:e,errors:n,loading:!1,networkStatus:_.ready,stale:!1})}});r.setQuery(a,(function(t){t.subscriptions.add(g)}))}))},t.prototype.getQuery=function(t){return this.queries.get(t)||{listeners:new Set,invalidated:!1,document:null,newData:null,lastRequestId:1,observableQuery:null,subscriptions:new Set}},t.prototype.setQuery=function(t,e){var n=this.getQuery(t),o=Object(r.a)(Object(r.a)({},n),e(n));this.queries.set(t,o)},t.prototype.invalidate=function(t,e){void 0===e&&(e=!0),t&&this.setQuery(t,(function(){return{invalidated:e}}))},t.prototype.prepareContext=function(t){void 0===t&&(t={});var e=this.localState.prepareContext(t);return Object(r.a)(Object(r.a)({},e),{clientAwareness:this.clientAwareness})},t.prototype.checkInFlight=function(t){var e=this.queryStore.get(t);return e&&e.networkStatus!==_.ready&&e.networkStatus!==_.error},t.prototype.startPollingQuery=function(t,e,n){var o=this,a=t.pollInterval;if(Object(s.b)(a,18),!this.ssrMode){var i=this.pollingInfoByQueryId.get(e);i||this.pollingInfoByQueryId.set(e,i={}),i.interval=a,i.options=Object(r.a)(Object(r.a)({},t),{fetchPolicy:"network-only"});var c=function(){var t=o.pollingInfoByQueryId.get(e);t&&(o.checkInFlight(e)?l():o.fetchQuery(e,t.options,G.poll).then(l,l))},l=function(){var t=o.pollingInfoByQueryId.get(e);t&&(clearTimeout(t.timeout),t.timeout=setTimeout(c,t.interval))};n&&this.addQueryListener(e,n),l()}return e},t.prototype.stopPollingQuery=function(t){this.pollingInfoByQueryId.delete(t)},t}(),N=function(){function t(t){this.cache=t}return t.prototype.getCache=function(){return this.cache},t.prototype.markQueryResult=function(t,e,n,r,a){void 0===a&&(a=!1);var i=!Object(o.q)(t);a&&Object(o.q)(t)&&t.data&&(i=!0),!r&&i&&this.cache.write({result:t.data,dataId:"ROOT_QUERY",query:e,variables:n})},t.prototype.markSubscriptionResult=function(t,e,n){Object(o.q)(t)||this.cache.write({result:t.data,dataId:"ROOT_SUBSCRIPTION",query:e,variables:n})},t.prototype.markMutationInit=function(t){var e,n=this;t.optimisticResponse&&(e="function"==typeof t.optimisticResponse?t.optimisticResponse(t.variables):t.optimisticResponse,this.cache.recordOptimisticTransaction((function(r){var o=n.cache;n.cache=r;try{n.markMutationResult({mutationId:t.mutationId,result:{data:e},document:t.document,variables:t.variables,updateQueries:t.updateQueries,update:t.update})}finally{n.cache=o}}),t.mutationId))},t.prototype.markMutationResult=function(t){var e=this;if(!Object(o.q)(t.result)){var n=[{result:t.result.data,dataId:"ROOT_MUTATION",query:t.document,variables:t.variables}],r=t.updateQueries;r&&Object.keys(r).forEach((function(a){var i=r[a],c=i.query,s=i.updater,l=e.cache.diff({query:c.document,variables:c.variables,returnPartialData:!0,optimistic:!1}),u=l.result;if(l.complete){var p=Object(o.I)((function(){return s(u,{mutationResult:t.result,queryName:Object(o.n)(c.document)||void 0,queryVariables:c.variables})}));p&&n.push({result:p,dataId:"ROOT_QUERY",query:c.document,variables:c.variables})}})),this.cache.performTransaction((function(e){n.forEach((function(t){return e.write(t)}));var r=t.update;r&&Object(o.I)((function(){return r(e,t.result)}))}))}},t.prototype.markMutationComplete=function(t){var e=t.mutationId;t.optimisticResponse&&this.cache.removeOptimistic(e)},t.prototype.markUpdateQueryResult=function(t,e,n){this.cache.write({result:n,dataId:"ROOT_QUERY",variables:e,query:t})},t.prototype.reset=function(){return this.cache.reset()},t}(),P=function(){function t(t){var e=this;this.defaultOptions={},this.resetStoreCallbacks=[],this.clearStoreCallbacks=[];var n=t.cache,r=t.ssrMode,o=void 0!==r&&r,a=t.ssrForceFetchDelay,i=void 0===a?0:a,c=t.connectToDevTools,l=t.queryDeduplication,u=void 0===l||l,p=t.defaultOptions,d=t.assumeImmutableResults,h=void 0!==d&&d,f=t.resolvers,m=t.typeDefs,g=t.fragmentMatcher,v=t.name,b=t.version,y=t.link;if(!y&&f&&(y=C.empty()),!y||!n)throw new s.a(4);this.link=y,this.cache=n,this.store=new N(n),this.disableNetworkFetches=o||i>0,this.queryDeduplication=u,this.defaultOptions=p||{},this.typeDefs=m,i&&setTimeout((function(){return e.disableNetworkFetches=!1}),i),this.watchQuery=this.watchQuery.bind(this),this.query=this.query.bind(this),this.mutate=this.mutate.bind(this),this.resetStore=this.resetStore.bind(this),this.reFetchObservableQueries=this.reFetchObservableQueries.bind(this);void 0!==c&&(c&&"undefined"!=typeof window)&&(window.__APOLLO_CLIENT__=this),this.version="2.6.10",this.localState=new H({cache:n,client:this,resolvers:f,fragmentMatcher:g}),this.queryManager=new V({link:this.link,store:this.store,queryDeduplication:u,ssrMode:o,clientAwareness:{name:v,version:b},localState:this.localState,assumeImmutableResults:h,onBroadcast:function(){e.devToolsHookCb&&e.devToolsHookCb({action:{},state:{queries:e.queryManager.queryStore.getStore(),mutations:e.queryManager.mutationStore.getStore()},dataWithOptimisticResults:e.cache.extract(!0)})}})}return t.prototype.stop=function(){this.queryManager.stop()},t.prototype.watchQuery=function(t){return this.defaultOptions.watchQuery&&(t=Object(r.a)(Object(r.a)({},this.defaultOptions.watchQuery),t)),!this.disableNetworkFetches||"network-only"!==t.fetchPolicy&&"cache-and-network"!==t.fetchPolicy||(t=Object(r.a)(Object(r.a)({},t),{fetchPolicy:"cache-first"})),this.queryManager.watchQuery(t)},t.prototype.query=function(t){return this.defaultOptions.query&&(t=Object(r.a)(Object(r.a)({},this.defaultOptions.query),t)),Object(s.b)("cache-and-network"!==t.fetchPolicy,5),this.disableNetworkFetches&&"network-only"===t.fetchPolicy&&(t=Object(r.a)(Object(r.a)({},t),{fetchPolicy:"cache-first"})),this.queryManager.query(t)},t.prototype.mutate=function(t){return this.defaultOptions.mutate&&(t=Object(r.a)(Object(r.a)({},this.defaultOptions.mutate),t)),this.queryManager.mutate(t)},t.prototype.subscribe=function(t){return this.queryManager.startGraphQLSubscription(t)},t.prototype.readQuery=function(t,e){return void 0===e&&(e=!1),this.cache.readQuery(t,e)},t.prototype.readFragment=function(t,e){return void 0===e&&(e=!1),this.cache.readFragment(t,e)},t.prototype.writeQuery=function(t){var e=this.cache.writeQuery(t);return this.queryManager.broadcastQueries(),e},t.prototype.writeFragment=function(t){var e=this.cache.writeFragment(t);return this.queryManager.broadcastQueries(),e},t.prototype.writeData=function(t){var e=this.cache.writeData(t);return this.queryManager.broadcastQueries(),e},t.prototype.__actionHookForDevTools=function(t){this.devToolsHookCb=t},t.prototype.__requestRaw=function(t){return x(this.link,t)},t.prototype.initQueryManager=function(){return this.queryManager},t.prototype.resetStore=function(){var t=this;return Promise.resolve().then((function(){return t.queryManager.clearStore()})).then((function(){return Promise.all(t.resetStoreCallbacks.map((function(t){return t()})))})).then((function(){return t.reFetchObservableQueries()}))},t.prototype.clearStore=function(){var t=this;return Promise.resolve().then((function(){return t.queryManager.clearStore()})).then((function(){return Promise.all(t.clearStoreCallbacks.map((function(t){return t()})))}))},t.prototype.onResetStore=function(t){var e=this;return this.resetStoreCallbacks.push(t),function(){e.resetStoreCallbacks=e.resetStoreCallbacks.filter((function(e){return e!==t}))}},t.prototype.onClearStore=function(t){var e=this;return this.clearStoreCallbacks.push(t),function(){e.clearStoreCallbacks=e.clearStoreCallbacks.filter((function(e){return e!==t}))}},t.prototype.reFetchObservableQueries=function(t){return this.queryManager.reFetchObservableQueries(t)},t.prototype.extract=function(t){return this.cache.extract(t)},t.prototype.restore=function(t){return this.cache.restore(t)},t.prototype.addResolvers=function(t){this.localState.addResolvers(t)},t.prototype.setResolvers=function(t){this.localState.setResolvers(t)},t.prototype.getResolvers=function(){return 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e=this,n=t.selectionSet,a=t.rootValue,i=t.execContext,c=i.fragmentMap,l=i.contextValue,u=i.variableValues,p={result:null},d=[],h=l.store.get(a.id),f=h&&h.__typename||"ROOT_QUERY"===a.id&&"Query"||void 0;function m(t){var e;return t.missing&&(p.missing=p.missing||[],(e=p.missing).push.apply(e,t.missing)),t.result}return n.selections.forEach((function(t){var n;if(Object(o.F)(t,u))if(Object(o.t)(t)){var p=m(e.executeField(h,f,t,i));void 0!==p&&d.push(((n={})[Object(o.E)(t)]=p,n))}else{var g=void 0;if(Object(o.v)(t))g=t;else if(!(g=c[t.name.value]))throw new s.a(9);var v=g.typeCondition&&g.typeCondition.name.value,b=!v||i.fragmentMatcher(a,v,l);if(b){var y=e.executeSelectionSet({selectionSet:g.selectionSet,rootValue:a,execContext:i});"heuristic"===b&&y.missing&&(y=Object(r.a)(Object(r.a)({},y),{missing:y.missing.map((function(t){return 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Array.isArray(c.result)?this.combineExecResults(c,this.executeSubSelectedArray({field:n,array:c.result,execContext:r})):n.selectionSet?null==c.result?c:this.combineExecResults(c,this.executeSelectionSet({selectionSet:n.selectionSet,rootValue:c.result,execContext:r})):(Tt(n,c.result),this.freezeResults,c)},t.prototype.combineExecResults=function(){for(var t,e=[],n=0;n<arguments.length;n++)e[n]=arguments[n];return e.forEach((function(e){e.missing&&(t=t||[]).push.apply(t,e.missing)})),{result:e.pop().result,missing:t}},t.prototype.executeSubSelectedArray=function(t){var e,n=this,r=t.field,o=t.array,a=t.execContext;function i(t){return t.missing&&(e=e||[]).push.apply(e,t.missing),t.result}return o=o.map((function(t){return null===t?null:Array.isArray(t)?i(n.executeSubSelectedArray({field:r,array:t,execContext:a})):r.selectionSet?i(n.executeSelectionSet({selectionSet:r.selectionSet,rootValue:t,execContext:a})):(Tt(r,t),t)})),this.freezeResults,{result:o,missing:e}},t}();function 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0===r?Lt():r,a=t.variables,i=t.dataIdFromObject,c=t.fragmentMatcherFunction;return this.writeResultToStore({dataId:"ROOT_QUERY",result:n,document:e,store:o,variables:a,dataIdFromObject:i,fragmentMatcherFunction:c})},t.prototype.writeResultToStore=function(t){var e=t.dataId,n=t.result,r=t.document,a=t.store,i=void 0===a?Lt():a,c=t.variables,s=t.dataIdFromObject,l=t.fragmentMatcherFunction,u=Object(o.m)(r);try{return this.writeSelectionSetToStore({result:n,dataId:e,selectionSet:u.selectionSet,context:{store:i,processedData:{},variables:Object(o.c)({},Object(o.h)(u),c),dataIdFromObject:s,fragmentMap:Object(o.g)(Object(o.j)(r)),fragmentMatcherFunction:l}})}catch(t){throw Dt(t,r)}},t.prototype.writeSelectionSetToStore=function(t){var e=this,n=t.result,r=t.dataId,a=t.selectionSet,i=t.context,c=i.variables,l=i.store,u=i.fragmentMap;return a.selections.forEach((function(t){var a;if(Object(o.F)(t,c))if(Object(o.t)(t)){var l=Object(o.E)(t),p=n[l];if(void 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v=u+"."+m,b=!0;if(Vt(v)||(v="$"+v),h){var y=h(l);Object(s.b)(!y||!Vt(y),4),(y||"number"==typeof y&&0===y)&&(v=y,b=!1)}Nt(v,c,p.processedData)||this.writeSelectionSetToStore({dataId:v,result:l,selectionSet:c.selectionSet,context:p});var S=l.__typename;n=Object(o.H)({id:v,typename:S},b);var C=(i=f.get(u))&&i[m];if(C!==n&&Object(o.u)(C)){var x=void 0!==C.typename,_=void 0!==S,w=x&&_&&C.typename!==S;Object(s.b)(!b||C.generated||w,5),Object(s.b)(!x||_,6),C.generated&&(w?b||f.delete(C.id):function t(e,n,i){if(e===n)return!1;var c=i.get(e),s=i.get(n),l=!1;Object.keys(c).forEach((function(e){var n=c[e],r=s[e];Object(o.u)(n)&&Vt(n.id)&&Object(o.u)(r)&&!Object(a.a)(n,r)&&t(n.id,r.id,i)&&(l=!0)})),i.delete(e);var u=Object(r.a)(Object(r.a)({},c),s);if(Object(a.a)(u,s))return l;return i.set(n,u),!0}(C.id,n.id,f))}}else n=null!=l&&"object"==typeof l?{type:"json",json:l}:l;(i=f.get(u))&&Object(a.a)(n,i[m])||f.set(u,Object(r.a)(Object(r.a)({},i),((e={})[m]=n,e)))},t.prototype.processArrayValue=function(t,e,n,r){var a=this;return t.map((function(t,i){if(null===t)return null;var c=e+"."+i;if(Array.isArray(t))return a.processArrayValue(t,c,n,r);var s=!0;if(r.dataIdFromObject){var l=r.dataIdFromObject(t);l&&(c=l,s=!1)}return Nt(c,n,r.processedData)||a.writeSelectionSetToStore({dataId:c,result:t,selectionSet:n,context:r}),Object(o.H)({id:c,typename:t.__typename},s)}))},t}();function Vt(t){return"$"===t[0]}function Nt(t,e,n){if(!n)return!1;if(n[t]){if(n[t].indexOf(e)>=0)return!0;n[t].push(e)}else n[t]=[e];return!1}var Pt={fragmentMatcher:new Mt,dataIdFromObject:jt,addTypename:!0,resultCaching:!0,freezeResults:!1};function jt(t){if(t.__typename){if(void 0!==t.id)return t.__typename+":"+t.id;if(void 0!==t._id)return t.__typename+":"+t._id}return null}var Ut=Object.prototype.hasOwnProperty,Wt=function(t){function e(e,n,r){var o=t.call(this,Object.create(null))||this;return o.optimisticId=e,o.parent=n,o.transaction=r,o}return Object(r.c)(e,t),e.prototype.toObject=function(){return Object(r.a)(Object(r.a)({},this.parent.toObject()),this.data)},e.prototype.get=function(t){return Ut.call(this.data,t)?this.data[t]:this.parent.get(t)},e}(Ft),Qt=function(t){function e(e){void 0===e&&(e={});var n=t.call(this)||this;n.watches=new Set,n.typenameDocumentCache=new Map,n.cacheKeyRoot=new St(o.e),n.silenceBroadcast=!1,n.config=Object(r.a)(Object(r.a)({},Pt),e),n.config.customResolvers&&(n.config.cacheRedirects=n.config.customResolvers),n.config.cacheResolvers&&(n.config.cacheRedirects=n.config.cacheResolvers),n.addTypename=!!n.config.addTypename,n.data=n.config.resultCaching?new Gt:new Ft,n.optimisticData=n.data,n.storeWriter=new Bt,n.storeReader=new Ot({cacheKeyRoot:n.cacheKeyRoot,freezeResults:e.freezeResults});var a=n,i=a.maybeBroadcastWatch;return n.maybeBroadcastWatch=wt((function(t){return i.call(n,t)}),{makeCacheKey:function(t){if(!t.optimistic&&!t.previousResult)return a.data instanceof Gt?a.cacheKeyRoot.lookup(t.query,JSON.stringify(t.variables)):void 0}}),n}return Object(r.c)(e,t),e.prototype.restore=function(t){return t&&this.data.replace(t),this},e.prototype.extract=function(t){return void 0===t&&(t=!1),(t?this.optimisticData:this.data).toObject()},e.prototype.read=function(t){if("string"==typeof t.rootId&&void 0===this.data.get(t.rootId))return null;var e=this.config.fragmentMatcher,n=e&&e.match;return this.storeReader.readQueryFromStore({store:t.optimistic?this.optimisticData:this.data,query:this.transformDocument(t.query),variables:t.variables,rootId:t.rootId,fragmentMatcherFunction:n,previousResult:t.previousResult,config:this.config})||null},e.prototype.write=function(t){var e=this.config.fragmentMatcher,n=e&&e.match;this.storeWriter.writeResultToStore({dataId:t.dataId,result:t.result,variables:t.variables,document:this.transformDocument(t.query),store:this.data,dataIdFromObject:this.config.dataIdFromObject,fragmentMatcherFunction:n}),this.broadcastWatches()},e.prototype.diff=function(t){var e=this.config.fragmentMatcher,n=e&&e.match;return this.storeReader.diffQueryAgainstStore({store:t.optimistic?this.optimisticData:this.data,query:this.transformDocument(t.query),variables:t.variables,returnPartialData:t.returnPartialData,previousResult:t.previousResult,fragmentMatcherFunction:n,config:this.config})},e.prototype.watch=function(t){var e=this;return this.watches.add(t),function(){e.watches.delete(t)}},e.prototype.evict=function(t){throw new s.a(7)},e.prototype.reset=function(){return this.data.clear(),this.broadcastWatches(),Promise.resolve()},e.prototype.removeOptimistic=function(t){for(var e=[],n=0,r=this.optimisticData;r instanceof Wt;)r.optimisticId===t?++n:e.push(r),r=r.parent;if(n>0){for(this.optimisticData=r;e.length>0;){var o=e.pop();this.performTransaction(o.transaction,o.optimisticId)}this.broadcastWatches()}},e.prototype.performTransaction=function(t,e){var n=this.data,r=this.silenceBroadcast;this.silenceBroadcast=!0,"string"==typeof e&&(this.data=this.optimisticData=new Wt(e,this.optimisticData,t));try{t(this)}finally{this.silenceBroadcast=r,this.data=n}this.broadcastWatches()},e.prototype.recordOptimisticTransaction=function(t,e){return this.performTransaction(t,e)},e.prototype.transformDocument=function(t){if(this.addTypename){var e=this.typenameDocumentCache.get(t);return e||(e=Object(o.a)(t),this.typenameDocumentCache.set(t,e),this.typenameDocumentCache.set(e,e)),e}return t},e.prototype.broadcastWatches=function(){var t=this;this.silenceBroadcast||this.watches.forEach((function(e){return t.maybeBroadcastWatch(e)}))},e.prototype.maybeBroadcastWatch=function(t){t.callback(this.diff({query:t.query,variables:t.variables,previousResult:t.previousResult&&t.previousResult(),optimistic:t.optimistic}))},e}(K),Yt=n(61),Kt={http:{includeQuery:!0,includeExtensions:!1},headers:{accept:"*/*","content-type":"application/json"},options:{method:"POST"}},$t=function(t,e,n){var r=new Error(n);throw r.name="ServerError",r.response=t,r.statusCode=t.status,r.result=e,r},Xt=function(t,e){var n;try{n=JSON.stringify(t)}catch(t){var r=new s.a(2);throw r.parseError=t,r}return n},Zt=function(t){void 0===t&&(t={});var e=t.uri,n=void 0===e?"/graphql":e,o=t.fetch,a=t.includeExtensions,i=t.useGETForQueries,l=Object(r.e)(t,["uri","fetch","includeExtensions","useGETForQueries"]);!function(t){if(!t&&"undefined"==typeof fetch){throw"undefined"==typeof window&&"node-fetch",new s.a(1)}}(o),o||(o=fetch);var u={http:{includeExtensions:a},options:l.fetchOptions,credentials:l.credentials,headers:l.headers};return new C((function(t){var e=function(t,e){var n=t.getContext().uri;return n||("function"==typeof e?e(t):e||"/graphql")}(t,n),a=t.getContext(),s={};if(a.clientAwareness){var l=a.clientAwareness,p=l.name,d=l.version;p&&(s["apollographql-client-name"]=p),d&&(s["apollographql-client-version"]=d)}var f,m=Object(r.a)({},s,a.headers),g={http:a.http,options:a.fetchOptions,credentials:a.credentials,headers:m},v=function(t,e){for(var n=[],o=2;o<arguments.length;o++)n[o-2]=arguments[o];var a=Object(r.a)({},e.options,{headers:e.headers,credentials:e.credentials}),i=e.http;n.forEach((function(t){a=Object(r.a)({},a,t.options,{headers:Object(r.a)({},a.headers,t.headers)}),t.credentials&&(a.credentials=t.credentials),i=Object(r.a)({},i,t.http)}));var c=t.operationName,s=t.extensions,l=t.variables,u=t.query,p={operationName:c,variables:l};return i.includeExtensions&&(p.extensions=s),i.includeQuery&&(p.query=Object(Yt.print)(u)),{options:a,body:p}}(t,Kt,u,g),b=v.options,y=v.body;if(!b.signal){var S=function(){if("undefined"==typeof AbortController)return{controller:!1,signal:!1};var t=new AbortController;return{controller:t,signal:t.signal}}(),C=S.controller,x=S.signal;(f=C)&&(b.signal=x)}if(i&&!t.query.definitions.some((function(t){return"OperationDefinition"===t.kind&&"mutation"===t.operation}))&&(b.method="GET"),"GET"===b.method){var _=function(t,e){var n=[],r=function(t,e){n.push(t+"="+encodeURIComponent(e))};"query"in e&&r("query",e.query);e.operationName&&r("operationName",e.operationName);if(e.variables){var o=void 0;try{o=Xt(e.variables)}catch(t){return{parseError:t}}r("variables",o)}if(e.extensions){var a=void 0;try{a=Xt(e.extensions)}catch(t){return{parseError:t}}r("extensions",a)}var i="",c=t,s=t.indexOf("#");-1!==s&&(i=t.substr(s),c=t.substr(0,s));var l=-1===c.indexOf("?")?"?":"&";return{newURI:c+l+n.join("&")+i}}(e,y),w=_.newURI,z=_.parseError;if(z)return h(z);e=w}else try{b.body=Xt(y)}catch(z){return h(z)}return new c((function(n){var r;return o(e,b).then((function(e){return t.setContext({response:e}),e})).then((r=t,function(t){return t.text().then((function(e){try{return JSON.parse(e)}catch(r){var n=r;return n.name="ServerParseError",n.response=t,n.statusCode=t.status,n.bodyText=e,Promise.reject(n)}})).then((function(e){return t.status>=300&&$t(t,e,"Response not successful: Received status code "+t.status),Array.isArray(e)||e.hasOwnProperty("data")||e.hasOwnProperty("errors")||$t(t,e,"Server response was missing for query '"+(Array.isArray(r)?r.map((function(t){return t.operationName})):r.operationName)+"'."),e}))})).then((function(t){return n.next(t),n.complete(),t})).catch((function(t){"AbortError"!==t.name&&(t.result&&t.result.errors&&t.result.data&&n.next(t.result),n.error(t))})),function(){f&&f.abort()}}))}))};var Jt=function(t){function e(e){return t.call(this,Zt(e).request)||this}return Object(r.c)(e,t),e}(C);function te(t){return new C((function(e,n){return new c((function(r){var o,a,i;try{o=n(e).subscribe({next:function(o){o.errors&&(i=t({graphQLErrors:o.errors,response:o,operation:e,forward:n}))?a=i.subscribe({next:r.next.bind(r),error:r.error.bind(r),complete:r.complete.bind(r)}):r.next(o)},error:function(o){(i=t({operation:e,networkError:o,graphQLErrors:o&&o.result&&o.result.errors,forward:n}))?a=i.subscribe({next:r.next.bind(r),error:r.error.bind(r),complete:r.complete.bind(r)}):r.error(o)},complete:function(){i||r.complete.bind(r)()}})}catch(o){t({networkError:o,operation:e,forward:n}),r.error(o)}return function(){o&&o.unsubscribe(),a&&o.unsubscribe()}}))}))}!function(t){function e(e){var n=t.call(this)||this;return n.link=te(e),n}Object(r.c)(e,t),e.prototype.request=function(t,e){return this.link.request(t,e)}}(C);var ee=n(34),ne=["request","uri","credentials","headers","fetch","fetchOptions","clientState","onError","cacheRedirects","cache","name","version","resolvers","typeDefs","fragmentMatcher"],re=function(t){function e(e){void 0===e&&(e={});e&&Object.keys(e).filter((function(t){return-1===ne.indexOf(t)})).length;var n=e.request,r=e.uri,o=e.credentials,a=e.headers,i=e.fetch,l=e.fetchOptions,u=e.clientState,p=e.cacheRedirects,d=e.onError,h=e.name,f=e.version,m=e.resolvers,g=e.typeDefs,v=e.fragmentMatcher,b=e.cache;Object(s.b)(!b||!p,1),b||(b=p?new Qt({cacheRedirects:p}):new Qt);var y=te(d||function(t){var e=t.graphQLErrors;t.networkError;e&&e.forEach((function(t){t.message,t.locations,t.path;return!0}))}),S=!!n&&new C((function(t,e){return new c((function(r){var o;return Promise.resolve(t).then((function(t){return n(t)})).then((function(){o=e(t).subscribe({next:r.next.bind(r),error:r.error.bind(r),complete:r.complete.bind(r)})})).catch(r.error.bind(r)),function(){o&&o.unsubscribe()}}))})),x=new Jt({uri:r||"/graphql",fetch:i,fetchOptions:l||{},credentials:o||"same-origin",headers:a||{}}),_=C.from([y,S,x].filter((function(t){return!!t}))),w=m,z=g,E=v;return u&&(u.defaults&&b.writeData({data:u.defaults}),w=u.resolvers,z=u.typeDefs,E=u.fragmentMatcher),t.call(this,{cache:b,link:_,name:h,version:f,resolvers:w,typeDefs:z,fragmentMatcher:E})||this}return Object(r.c)(e,t),e}(j);e.default=re}])}));
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