@precisa-saude/fhir 0.7.0 → 0.9.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/{chunk-LYDCZW4C.cjs → chunk-D6XKCRS2.cjs} +3 -3
- package/dist/{chunk-LYDCZW4C.cjs.map → chunk-D6XKCRS2.cjs.map} +1 -1
- package/dist/{chunk-YXYGKTVB.js → chunk-GTKRPCZB.js} +2 -2
- package/dist/{chunk-ZYSD6A2K.cjs → chunk-MJ254F5K.cjs} +440 -2
- package/dist/chunk-MJ254F5K.cjs.map +1 -0
- package/dist/{chunk-4KGWSF55.js → chunk-N6J26FVW.js} +2 -2
- package/dist/{chunk-CPZ7YNON.cjs → chunk-PJJVDGX4.cjs} +4 -4
- package/dist/{chunk-CPZ7YNON.cjs.map → chunk-PJJVDGX4.cjs.map} +1 -1
- package/dist/chunk-R4MUCMO3.js +917 -0
- package/dist/chunk-R4MUCMO3.js.map +1 -0
- package/dist/cli.js +425 -1
- package/dist/{converter-Dee-qjBV.d.cts → converter-BAWBB9Gp.d.cts} +1 -1
- package/dist/{converter-C-QpCcTL.d.ts → converter-D74wBs5k.d.ts} +1 -1
- package/dist/converter.cjs +3 -3
- package/dist/converter.d.cts +2 -2
- package/dist/converter.d.ts +2 -2
- package/dist/converter.js +2 -2
- package/dist/{fhir-types-D9hUzGrc.d.ts → fhir-types-jTJayiwn.d.cts} +8 -1
- package/dist/{fhir-types-D9hUzGrc.d.cts → fhir-types-jTJayiwn.d.ts} +8 -1
- package/dist/importer.d.cts +1 -1
- package/dist/importer.d.ts +1 -1
- package/dist/index.cjs +79 -5
- package/dist/index.cjs.map +1 -1
- package/dist/index.d.cts +62 -5
- package/dist/index.d.ts +62 -5
- package/dist/index.js +77 -3
- package/dist/index.js.map +1 -1
- package/dist/reference-ranges.cjs +3 -3
- package/dist/reference-ranges.js +2 -2
- package/dist/units.cjs +2 -2
- package/dist/units.js +1 -1
- package/dist/validators.d.cts +1 -1
- package/dist/validators.d.ts +1 -1
- package/package.json +1 -1
- package/dist/chunk-R25V2E6S.js +0 -479
- package/dist/chunk-R25V2E6S.js.map +0 -1
- package/dist/chunk-ZYSD6A2K.cjs.map +0 -1
- /package/dist/{chunk-YXYGKTVB.js.map → chunk-GTKRPCZB.js.map} +0 -0
- /package/dist/{chunk-4KGWSF55.js.map → chunk-N6J26FVW.js.map} +0 -0
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{"version":3,"sources":["../src/units.ts"],"sourcesContent":["/**\n * Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Map units to UCUM (Unified Code for Units of Measure)\n * See: https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n // Dimensionless / special measurements\n '[pH]': '[pH]',\n '{ratio}': '{ratio}',\n '{specific gravity}': '{specific gravity}',\n\n '/µL': '/uL',\n // Percentage\n '%': '%',\n // Count units\n '10³/µL': '10*3/uL',\n '10⁶/µL': '10*6/uL',\n // Volume\n fL: 'fL',\n g: 'g',\n\n // Mass concentration\n 'g/dL': 'g/dL',\n L: 'L',\n // Molar concentration\n 'mEq/L': 'meq/L',\n\n mg: 'mg',\n 'mg/dL': 'mg/dL',\n mL: 'mL',\n 'mmol/L': 'mmol/L',\n 'mUI/mL': 'm[IU]/mL',\n\n ng: 'ng',\n\n 'ng/dL': 'ng/dL',\n 'ng/mL': 'ng/mL',\n 'nmol/L': 'nmol/L',\n // Mass\n pg: 'pg',\n\n 'pg/mL': 'pg/mL',\n pH: '[pH]',\n // Enzyme activity\n 'U/L': 'U/L',\n // Special units\n 'U/mL': 'U/mL',\n 'UI/L': '[IU]/L',\n\n 'UI/mL': '[IU]/mL',\n\n µg: 'ug',\n 'µg/dL': 'ug/dL',\n 'µmol/L': 'umol/L',\n 'µUI/mL': 'u[IU]/mL',\n};\n\n/**\n * Default units for biomarkers when source data doesn't provide one\n * These are the most common units used in Brazilian labs\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n // Proteins\n Albumin: 'g/dL',\n AlkalinePhosphatase: 'U/L',\n // Liver\n ALT: 'U/L',\n AST: 'U/L',\n\n Calcium: 'mg/dL',\n Chloride: 'mEq/L',\n // Lipids\n Cholesterol: 'mg/dL',\n // Kidney\n Creatinine: 'mg/dL',\n eAG: 'mg/dL',\n Ferritin: 'ng/mL',\n\n FolicAcid: 'ng/mL',\n GGT: 'U/L',\n // Glucose/Diabetes\n Glucose: 'mg/dL',\n\n HbA1c: '%',\n Hct: '%',\n\n HDL: 'mg/dL',\n // Hematology\n Hgb: 'g/dL',\n Insulin: 'µUI/mL',\n\n // Iron studies\n Iron: 'µg/dL',\n LDL: 'mg/dL',\n Magnesium: 'mg/dL',\n NonHDL_Cholesterol: 'mg/dL',\n\n // Urinalysis - dimensionless\n pH_Urine: '[pH]',\n Potassium: 'mEq/L',\n RDW: '%',\n // Electrolytes\n Sodium: 'mEq/L',\n SpecificGravity_Urine: '{specific gravity}',\n\n T3Free: 'pg/mL',\n T4Free: 'ng/dL',\n TIBC: 'µg/dL',\n TotalProtein: 'g/dL',\n\n TransferrinSaturation: '%',\n Triglycerides: 'mg/dL',\n // Thyroid\n TSH: 'µUI/mL',\n\n Urea: 'mg/dL',\n UricAcid: 'mg/dL',\n\n // Vitamins\n VitaminB12: 'pg/mL',\n VitaminD: 'ng/mL',\n VLDL: 'mg/dL',\n};\n\n/**\n * Convert unit to UCUM format\n */\nexport function unitToUCUM(unit: string): string {\n return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n aliases: Record<string, string>;\n canonicalUcum: string;\n canonicalUnit: string;\n molecularWeight?: number;\n siUcum: string;\n siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n '/ul': '/uL',\n '/µl': '/uL',\n '10*3/ul': 'K/uL',\n 'cells/ul': '/uL',\n 'cells/µl': '/uL',\n 'k/ul': 'K/uL',\n 'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: '10*3/uL',\n canonicalUnit: 'K/uL',\n siUcum: '10*3/uL',\n siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n kg: 'kg',\n lb: '[lb_av]',\n lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: 'kg',\n canonicalUnit: 'kg',\n siUcum: 'kg',\n siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n '/hpf': '/HPF',\n '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: '/[HPF]',\n canonicalUnit: '/HPF',\n siUcum: '/[HPF]',\n siUnit: '/HPF',\n};\n\n/** Percentage biomarkers — canonical and SI both use %. */\nconst PERCENTAGE_ALIASES: Record<string, string> = { '%': '%', pct: '%', percent: '%' };\nconst PERCENTAGE: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: '%',\n canonicalUnit: '%',\n siUcum: '%',\n siUnit: '%',\n};\n\n/** Enzyme activity — canonical and SI both use U/L. */\nconst ENZYME_ALIASES: Record<string, string> = { 'iu/l': 'U/L', 'u/l': 'U/L' };\nconst ENZYME: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: 'U/L',\n canonicalUnit: 'U/L',\n siUcum: 'U/L',\n siUnit: 'U/L',\n};\n\n/** Monovalent electrolytes — mEq/L ↔ mmol/L (1:1). */\nconst ELECTROLYTE_MONO_ALIASES: Record<string, string> = { 'meq/l': 'mEq/L', 'mmol/l': 'mmol/L' };\nconst ELECTROLYTE_MONO: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: 'meq/L',\n canonicalUnit: 'mEq/L',\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n};\n\n/** CAC scores — Agatston Units (AU), dimensionless. */\nconst CAC_ALIASES: Record<string, string> = { au: 'AU' };\nconst CAC: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: '{score}',\n canonicalUnit: 'AU',\n siUcum: '{score}',\n siUnit: 'AU',\n};\n\n/** nmol/L biomarkers — same unit for canonical and SI. */\nconst NMOL_L_ALIASES: Record<string, string> = { 'nmol/l': 'nmol/L' };\nconst NMOL_L: Omit<BiomarkerUnitConfig, 'aliases'> = {\n canonicalUcum: 'nmol/L',\n canonicalUnit: 'nmol/L',\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n AFP: {\n aliases: { 'ng/ml': 'ng/mL' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ng/mL',\n siUnit: 'ng/mL',\n },\n Albumin: {\n aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n canonicalUcum: 'g/dL',\n canonicalUnit: 'g/dL',\n siUcum: 'g/L',\n siUnit: 'g/L',\n },\n AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },\n ALT: { aliases: ENZYME_ALIASES, ...ENZYME },\n AMH: {\n aliases: { 'ng/ml': 'ng/mL', 'pmol/l': 'pmol/L' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n molecularWeight: 12_500,\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },\n AntiThyroglobulin: {\n aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n canonicalUcum: '[iU]/mL',\n canonicalUnit: 'IU/mL',\n siUcum: '[iU]/mL',\n siUnit: 'IU/mL',\n },\n AntiTPO: {\n aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n canonicalUcum: '[iU]/mL',\n canonicalUnit: 'IU/mL',\n siUcum: '[iU]/mL',\n siUnit: 'IU/mL',\n },\n AoA1: {\n aliases: { 'mg/dl': 'mg/dL' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n siUcum: 'mg/dL',\n siUnit: 'mg/dL',\n },\n AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },\n ApoB: {\n aliases: { 'mg/dl': 'mg/dL' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n siUcum: 'mg/dL',\n siUnit: 'mg/dL',\n },\n AST: { aliases: ENZYME_ALIASES, ...ENZYME },\n Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n BilirubinDirect: {\n aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 584.66,\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n BilirubinIndirect: {\n aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 584.66,\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n BilirubinTotal: {\n aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 584.66,\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n BMI: {\n aliases: { 'kg/m2': 'kg/m²', 'kg/m²': 'kg/m²' },\n canonicalUcum: 'kg/m2',\n canonicalUnit: 'kg/m²',\n siUcum: 'kg/m2',\n siUnit: 'kg/m²',\n },\n BNP: {\n aliases: { 'pg/ml': 'pg/mL' },\n canonicalUcum: 'pg/mL',\n canonicalUnit: 'pg/mL',\n siUcum: 'pg/mL',\n siUnit: 'pg/mL',\n },\n CA125: {\n aliases: { 'u/ml': 'U/mL' },\n canonicalUcum: 'U/mL',\n canonicalUnit: 'U/mL',\n siUcum: 'U/mL',\n siUnit: 'U/mL',\n },\n CAC_LAD: { aliases: CAC_ALIASES, ...CAC },\n CAC_LCX: { aliases: CAC_ALIASES, ...CAC },\n CAC_LMA: { aliases: CAC_ALIASES, ...CAC },\n CAC_RCA: { aliases: CAC_ALIASES, ...CAC },\n Calcium: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 40.08,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n CEA: {\n aliases: { 'ng/ml': 'ng/mL' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ng/mL',\n siUnit: 'ng/mL',\n },\n Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n Cholesterol: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 386.65,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n CK: { aliases: ENZYME_ALIASES, ...ENZYME },\n CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n Cortisol: {\n aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n canonicalUcum: 'ug/dL',\n canonicalUnit: 'µg/dL',\n molecularWeight: 362.46,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n Creatinine: {\n aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 113.12,\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n CRP: {\n aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n canonicalUcum: 'mg/L',\n canonicalUnit: 'mg/L',\n siUcum: 'mg/L',\n siUnit: 'mg/L',\n },\n DHEAS: {\n aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'ug/dL',\n canonicalUnit: 'µg/dL',\n molecularWeight: 368.49,\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n DHT: {\n aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n canonicalUcum: 'ng/dL',\n canonicalUnit: 'ng/dL',\n molecularWeight: 290.44,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n eGFR: {\n aliases: {\n 'ml/min/1,73 m2': 'mL/min/1.73m²',\n 'ml/min/1.73m2': 'mL/min/1.73m²',\n 'ml/min/1.73m²': 'mL/min/1.73m²',\n },\n canonicalUcum: 'mL/min/{1.73_m2}',\n canonicalUnit: 'mL/min/1.73m²',\n siUcum: 'mL/min/{1.73_m2}',\n siUnit: 'mL/min/1.73m²',\n },\n Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n ESR: {\n aliases: { 'mm/h': 'mm/h', 'mm/hr': 'mm/h' },\n canonicalUcum: 'mm/h',\n canonicalUnit: 'mm/h',\n siUcum: 'mm/h',\n siUnit: 'mm/h',\n },\n Estradiol: {\n aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n canonicalUcum: 'pg/mL',\n canonicalUnit: 'pg/mL',\n molecularWeight: 272.38,\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n Ferritin: {\n aliases: {\n 'mcg/l': 'ng/mL',\n 'microg/l': 'ng/mL',\n 'ng/ml': 'ng/mL',\n 'µg/l': 'ng/mL',\n },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ug/L',\n siUnit: 'µg/L',\n },\n Folate: {\n aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n molecularWeight: 441.4,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n FSH: {\n aliases: {\n 'iu/l': 'mIU/mL',\n 'miu/ml': 'mIU/mL',\n 'ui/l': 'mIU/mL',\n },\n canonicalUcum: 'mIU/mL',\n canonicalUnit: 'mIU/mL',\n siUcum: '[iU]/L',\n siUnit: 'IU/L',\n },\n GGT: { aliases: ENZYME_ALIASES, ...ENZYME },\n Globulin: {\n aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n canonicalUcum: 'g/dL',\n canonicalUnit: 'g/dL',\n siUcum: 'g/L',\n siUnit: 'g/L',\n },\n Glucose: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 180.156,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n HDL: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 386.65,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n Hgb: {\n aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n canonicalUcum: 'g/dL',\n canonicalUnit: 'g/dL',\n siUcum: 'g/L',\n siUnit: 'g/L',\n },\n Homocysteine: {\n aliases: { 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'umol/L',\n canonicalUnit: 'µmol/L',\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n IgA: {\n aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n canonicalUcum: 'g/L',\n canonicalUnit: 'g/L',\n siUcum: 'g/L',\n siUnit: 'g/L',\n },\n IgG: {\n aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n canonicalUcum: 'g/L',\n canonicalUnit: 'g/L',\n siUcum: 'g/L',\n siUnit: 'g/L',\n },\n INR: {\n aliases: { '{ratio}': '{ratio}' },\n canonicalUcum: '{ratio}',\n canonicalUnit: '{ratio}',\n siUcum: '{ratio}',\n siUnit: '{ratio}',\n },\n Insulin: {\n aliases: {\n 'mu/l': 'uIU/mL',\n 'uiu/ml': 'uIU/mL',\n 'µu/ml': 'uIU/mL',\n 'µui/ml': 'uIU/mL',\n },\n canonicalUcum: 'u[iU]/mL',\n canonicalUnit: 'uIU/mL',\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n Iron: {\n aliases: {\n 'mcg/dl': 'mcg/dL',\n 'microg/dl': 'mcg/dL',\n 'ug/dl': 'mcg/dL',\n 'µg/dl': 'mcg/dL',\n },\n canonicalUcum: 'ug/dL',\n canonicalUnit: 'mcg/dL',\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n LDL: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 386.65,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n LDL_Peak_Size: {\n aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n canonicalUcum: 'Ao',\n canonicalUnit: 'Angstrom',\n siUcum: 'nm',\n siUnit: 'nm',\n },\n LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n Lead: {\n aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'ug/dL',\n canonicalUnit: 'µg/dL',\n molecularWeight: 207.2,\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n Leptin: {\n aliases: { 'ng/ml': 'ng/mL' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ng/mL',\n siUnit: 'ng/mL',\n },\n Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n LH: {\n aliases: {\n 'iu/l': 'mIU/mL',\n 'miu/ml': 'mIU/mL',\n 'ui/l': 'mIU/mL',\n },\n canonicalUcum: 'mIU/mL',\n canonicalUnit: 'mIU/mL',\n siUcum: '[iU]/L',\n siUnit: 'IU/L',\n },\n Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },\n Lipoprotein_a: {\n aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n canonicalUcum: 'nmol/L',\n canonicalUnit: 'nmol/L',\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n MCH: {\n aliases: { pg: 'pg' },\n canonicalUcum: 'pg',\n canonicalUnit: 'pg',\n siUcum: 'pg',\n siUnit: 'pg',\n },\n MCHC: {\n aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n canonicalUcum: 'g/dL',\n canonicalUnit: 'g/dL',\n siUcum: 'g/L',\n siUnit: 'g/L',\n },\n MCV: {\n aliases: { fl: 'fL' },\n canonicalUcum: 'fL',\n canonicalUnit: 'fL',\n siUcum: 'fL',\n siUnit: 'fL',\n },\n Mercury: {\n aliases: { 'mcg/l': 'µg/L', 'nmol/l': 'nmol/L', 'ug/l': 'µg/L', 'µg/l': 'µg/L' },\n canonicalUcum: 'ug/L',\n canonicalUnit: 'µg/L',\n molecularWeight: 200.59,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n Microalbumin_Urine: {\n aliases: { 'mg/l': 'mg/L' },\n canonicalUcum: 'mg/L',\n canonicalUnit: 'mg/L',\n siUcum: 'mg/L',\n siUnit: 'mg/L',\n },\n MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n MPV: {\n aliases: { fl: 'fL' },\n canonicalUcum: 'fL',\n canonicalUnit: 'fL',\n siUcum: 'fL',\n siUnit: 'fL',\n },\n Myeloperoxidase: {\n aliases: { 'pmol/l': 'pmol/L' },\n canonicalUcum: 'pmol/L',\n canonicalUnit: 'pmol/L',\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,\n // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.\n NonHDL_Cholesterol: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 386.65,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n NTproBNP: {\n aliases: { 'pg/ml': 'pg/mL' },\n canonicalUcum: 'pg/mL',\n canonicalUnit: 'pg/mL',\n siUcum: 'pg/mL',\n siUnit: 'pg/mL',\n },\n Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n Progesterone: {\n aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n molecularWeight: 314.46,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n Prolactin: {\n aliases: {\n 'microg/l': 'ng/mL',\n 'ng/ml': 'ng/mL',\n 'µg/l': 'ng/mL',\n },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ug/L',\n siUnit: 'µg/L',\n },\n ProthrombinTime: {\n aliases: { s: 's', sec: 's' },\n canonicalUcum: 's',\n canonicalUnit: 's',\n siUcum: 's',\n siUnit: 's',\n },\n PSA: {\n aliases: { 'ng/ml': 'ng/mL' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ng/mL',\n siUnit: 'ng/mL',\n },\n PSA_Free: {\n aliases: { 'ng/ml': 'ng/mL' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ng/mL',\n siUnit: 'ng/mL',\n },\n RBC: {\n aliases: {\n '/ul': '/uL',\n '/µl': '/uL',\n '10*6/ul': 'M/uL',\n 'cells/ul': '/uL',\n 'm/ul': 'M/uL',\n 'milhões/mm3': 'M/uL',\n 'milhões/mm³': 'M/uL',\n 'x10e6/ul': 'M/uL',\n },\n canonicalUcum: '10*6/uL',\n canonicalUnit: 'M/uL',\n siUcum: '10*6/uL',\n siUnit: 'M/uL',\n },\n RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n RheumatoidFactor: {\n aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n canonicalUcum: '[iU]/mL',\n canonicalUnit: 'IU/mL',\n siUcum: '[iU]/mL',\n siUnit: 'IU/mL',\n },\n SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n T3Free: {\n aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n canonicalUcum: 'pg/mL',\n canonicalUnit: 'pg/mL',\n molecularWeight: 650.98,\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n T4Free: {\n aliases: { 'ng/dl': 'ng/dL', 'pmol/l': 'pmol/L' },\n canonicalUcum: 'ng/dL',\n canonicalUnit: 'ng/dL',\n molecularWeight: 776.87,\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n T4Total: {\n aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n canonicalUcum: 'ug/dL',\n canonicalUnit: 'µg/dL',\n molecularWeight: 776.87,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n Testosterone: {\n aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n canonicalUcum: 'ng/dL',\n canonicalUnit: 'ng/dL',\n molecularWeight: 288.42,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n TestosteroneFree: {\n aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n canonicalUcum: 'pg/mL',\n canonicalUnit: 'pg/mL',\n molecularWeight: 288.42,\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n TIBC: {\n aliases: {\n 'mcg/dl': 'mcg/dL',\n 'microg/dl': 'mcg/dL',\n 'ug/dl': 'mcg/dL',\n 'µg/dl': 'mcg/dL',\n },\n canonicalUcum: 'ug/dL',\n canonicalUnit: 'mcg/dL',\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n TotalProtein: {\n aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n canonicalUcum: 'g/dL',\n canonicalUnit: 'g/dL',\n siUcum: 'g/L',\n siUnit: 'g/L',\n },\n Triglycerides: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 885.4,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n TroponinI: {\n aliases: { 'ng/ml': 'ng/mL' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n siUcum: 'ng/mL',\n siUnit: 'ng/mL',\n },\n TroponinT: {\n aliases: { 'ng/l': 'ng/L' },\n canonicalUcum: 'ng/L',\n canonicalUnit: 'ng/L',\n siUcum: 'ng/L',\n siUnit: 'ng/L',\n },\n TSH: {\n aliases: {\n 'miu/l': 'uIU/mL',\n 'mui/l': 'uIU/mL',\n 'uiu/ml': 'uIU/mL',\n 'µui/ml': 'uIU/mL',\n },\n canonicalUcum: 'u[iU]/mL',\n canonicalUnit: 'uIU/mL',\n siUcum: 'mIU/L',\n siUnit: 'mIU/L',\n },\n Urea: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 60.06,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n UricAcid: {\n aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 168.11,\n siUcum: 'umol/L',\n siUnit: 'µmol/L',\n },\n VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n VATVolume: {\n aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n canonicalUcum: 'cm3',\n canonicalUnit: 'cm³',\n siUcum: 'cm3',\n siUnit: 'cm³',\n },\n VitaminB12: {\n aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n canonicalUcum: 'pg/mL',\n canonicalUnit: 'pg/mL',\n siUcum: 'pmol/L',\n siUnit: 'pmol/L',\n },\n VitaminD: {\n aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n canonicalUcum: 'ng/mL',\n canonicalUnit: 'ng/mL',\n molecularWeight: 384.64,\n siUcum: 'nmol/L',\n siUnit: 'nmol/L',\n },\n VLDL: {\n aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n canonicalUcum: 'mg/dL',\n canonicalUnit: 'mg/dL',\n molecularWeight: 386.65,\n siUcum: 'mmol/L',\n siUnit: 'mmol/L',\n },\n WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n 'g/dL -> g/L': 10,\n 'g/L -> g/dL': 0.1,\n 'g/L -> mg/dL': 100,\n 'mEq/L -> mmol/L': 1,\n 'mg/dL -> g/L': 0.01,\n 'mmol/L -> mEq/L': 1,\n 'ng/dL -> pg/mL': 10,\n 'ng/mL -> µg/L': 1,\n 'pg/mL -> ng/dL': 0.1,\n 'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n * result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n * mg/dL → mmol/L: value × 10 / MW\n * mg/dL → µmol/L: value × 10000 / MW (or equivalently × 10 / MW × 1000)\n * ng/mL → nmol/L: value × 1000 / MW\n * pg/mL → pmol/L: value × 1000 / MW\n * ng/dL → nmol/L: value × 10 / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW (when divideByMW is true)\n * result = value × MW / scale (when divideByMW is false)\n */\ninterface MWConversion {\n divideByMW: boolean;\n scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n 'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n 'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n 'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n 'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n 'ng/dL -> pmol/L': { divideByMW: true, scale: 10_000 },\n 'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n 'ng/mL -> pmol/L': { divideByMW: true, scale: 1_000_000 },\n 'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n 'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n 'nmol/L -> µg/dL': { divideByMW: false, scale: 10_000 },\n 'nmol/L -> µg/L': { divideByMW: false, scale: 1000 },\n 'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n 'pmol/L -> ng/dL': { divideByMW: false, scale: 10_000 },\n 'pmol/L -> ng/mL': { divideByMW: false, scale: 1_000_000 },\n 'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n 'µg/dL -> nmol/L': { divideByMW: true, scale: 10_000 },\n 'µg/dL -> µmol/L': { divideByMW: true, scale: 10 },\n 'µg/L -> nmol/L': { divideByMW: true, scale: 1000 },\n 'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n 'µmol/L -> µg/dL': { divideByMW: false, scale: 10 },\n};\n\nexport interface ConversionResult {\n unit: string;\n value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n value: number,\n fromUnit: string,\n toUnit: string,\n biomarkerCode: string,\n): ConversionResult | null {\n const config = BIOMARKER_UNITS[biomarkerCode];\n if (!config) return null;\n\n const normFrom = normalizeUnit(fromUnit, config);\n const normTo = normalizeUnit(toUnit, config);\n\n if (normFrom === normTo) {\n return { unit: normTo, value };\n }\n\n const key = `${normFrom} -> ${normTo}`;\n\n const fixedFactor = FIXED_FACTORS[key];\n if (fixedFactor !== undefined) {\n return { unit: normTo, value: value * fixedFactor };\n }\n\n const mwConv = MW_CONVERSIONS[key];\n if (mwConv && config.molecularWeight) {\n const result = mwConv.divideByMW\n ? (value * mwConv.scale) / config.molecularWeight\n : (value * config.molecularWeight) / mwConv.scale;\n return { unit: normTo, value: result };\n }\n\n return 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