@precisa-saude/fhir 0.5.0 → 0.6.0

package/dist/{chunk-VPMT4MRS.js → chunk-R25V2E6S.js}

@@ -189,10 +189,10 @@ var BIOMARKER_UNITS = {
   },
   Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
   Estradiol: {
-    // TODO: ng/dL ≠ pg/mL (1 ng/dL = 10 pg/mL) — display-only alias for now
-    aliases: { "ng/dl": "pg/mL", "pg/ml": "pg/mL" },
+    aliases: { "ng/dl": "ng/dL", "pg/ml": "pg/mL" },
     canonicalUcum: "pg/mL",
     canonicalUnit: "pg/mL",
+    molecularWeight: 272.38,
     siUcum: "pmol/L",
     siUnit: "pmol/L"
   },
@@ -343,8 +343,7 @@ var BIOMARKER_UNITS = {
   },
   RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
   TestosteroneFree: {
-    // TODO: pmol/L ≠ pg/mL (needs MW conversion) — display-only alias for now
-    aliases: { "pg/ml": "pg/mL", "pmol/l": "pg/mL" },
+    aliases: { "pg/ml": "pg/mL", "pmol/l": "pmol/L" },
     canonicalUcum: "pg/mL",
     canonicalUnit: "pg/mL",
     molecularWeight: 288.42,
@@ -423,6 +422,49 @@ function getCanonicalUnit(code) {
 function getSIUnit(code) {
   return BIOMARKER_UNITS[code]?.siUnit ?? null;
 }
+function normalizeUnit(unit, config) {
+  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;
+}
+var FIXED_FACTORS = {
+  "g/dL -> g/L": 10,
+  "g/L -> g/dL": 0.1,
+  "ng/dL -> pg/mL": 10,
+  "ng/mL -> \xB5g/L": 1,
+  "pg/mL -> ng/dL": 0.1,
+  "\xB5g/L -> ng/mL": 1
+};
+var MW_CONVERSIONS = {
+  "mg/dL -> mmol/L": { divideByMW: true, scale: 10 },
+  "mg/dL -> \xB5mol/L": { divideByMW: true, scale: 1e4 },
+  "mmol/L -> mg/dL": { divideByMW: false, scale: 10 },
+  "ng/dL -> nmol/L": { divideByMW: true, scale: 10 },
+  "ng/mL -> nmol/L": { divideByMW: true, scale: 1e3 },
+  "nmol/L -> ng/dL": { divideByMW: false, scale: 10 },
+  "nmol/L -> ng/mL": { divideByMW: false, scale: 1e3 },
+  "pg/mL -> pmol/L": { divideByMW: true, scale: 1e3 },
+  "pmol/L -> pg/mL": { divideByMW: false, scale: 1e3 },
+  "\xB5mol/L -> mg/dL": { divideByMW: false, scale: 1e4 }
+};
+function convertUnit(value, fromUnit, toUnit, biomarkerCode) {
+  const config = BIOMARKER_UNITS[biomarkerCode];
+  if (!config) return null;
+  const normFrom = normalizeUnit(fromUnit, config);
+  const normTo = normalizeUnit(toUnit, config);
+  if (normFrom === normTo) {
+    return { unit: normTo, value };
+  }
+  const key = `${normFrom} -> ${normTo}`;
+  const fixedFactor = FIXED_FACTORS[key];
+  if (fixedFactor !== void 0) {
+    return { unit: normTo, value: value * fixedFactor };
+  }
+  const mwConv = MW_CONVERSIONS[key];
+  if (mwConv && config.molecularWeight) {
+    const result = mwConv.divideByMW ? value * mwConv.scale / config.molecularWeight : value * config.molecularWeight / mwConv.scale;
+    return { unit: normTo, value: result };
+  }
+  return null;
+}
 
 export {
   UNIT_TO_UCUM,
@@ -431,6 +473,7 @@ export {
   getDefaultUnit,
   BIOMARKER_UNITS,
   getCanonicalUnit,
-  getSIUnit
+  getSIUnit,
+  convertUnit
 };
-//# sourceMappingURL=chunk-VPMT4MRS.js.map
+//# sourceMappingURL=chunk-R25V2E6S.js.map

package/dist/chunk-R25V2E6S.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/units.ts"],"sourcesContent":["/**\n * Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Map units to UCUM (Unified Code for Units of Measure)\n * See: https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{ratio}': '{ratio}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  L: 'L',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  mL: 'mL',\n  'mmol/L': 'mmol/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  // Enzyme activity\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n};\n\n/**\n * Default units for biomarkers when source data doesn't provide one\n * These are the most common units used in Brazilian labs\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  // Proteins\n  Albumin: 'g/dL',\n  AlkalinePhosphatase: 'U/L',\n  // Liver\n  ALT: 'U/L',\n  AST: 'U/L',\n\n  Calcium: 'mg/dL',\n  Chloride: 'mEq/L',\n  // Lipids\n  Cholesterol: 'mg/dL',\n  // Kidney\n  Creatinine: 'mg/dL',\n  eAG: 'mg/dL',\n  Ferritin: 'ng/mL',\n\n  FolicAcid: 'ng/mL',\n  GGT: 'U/L',\n  // Glucose/Diabetes\n  Glucose: 'mg/dL',\n\n  HbA1c: '%',\n  Hct: '%',\n\n  HDL: 'mg/dL',\n  // Hematology\n  Hgb: 'g/dL',\n  Insulin: 'µUI/mL',\n\n  // Iron studies\n  Iron: 'µg/dL',\n  LDL: 'mg/dL',\n  Magnesium: 'mg/dL',\n  NonHDL_Cholesterol: 'mg/dL',\n\n  // Urinalysis - dimensionless\n  pH_Urine: '[pH]',\n  Potassium: 'mEq/L',\n  RDW: '%',\n  // Electrolytes\n  Sodium: 'mEq/L',\n  SpecificGravity_Urine: '{specific gravity}',\n\n  T3Free: 'pg/mL',\n  T4Free: 'ng/dL',\n  TIBC: 'µg/dL',\n  TotalProtein: 'g/dL',\n\n  TransferrinSaturation: '%',\n  Triglycerides: 'mg/dL',\n  // Thyroid\n  TSH: 'µUI/mL',\n\n  Urea: 'mg/dL',\n  UricAcid: 'mg/dL',\n\n  // Vitamins\n  VitaminB12: 'pg/mL',\n  VitaminD: 'ng/mL',\n  VLDL: 'mg/dL',\n};\n\n/**\n * Convert unit to UCUM format\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'mIU/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'ng/dL -> pg/mL': 10,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return 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package/dist/{chunk-35S3GSRK.js → chunk-YXYGKTVB.js}

@@ -1,6 +1,6 @@
 import {
   getCanonicalUnit
-} from "./chunk-VPMT4MRS.js";
+} from "./chunk-R25V2E6S.js";
 
 // src/reference-ranges.ts
 var biomarkerRangeDefinitions = {
@@ -1661,4 +1661,4 @@ export {
   getFallbackReferenceRange,
   applyFallbackReferenceRanges
 };
-//# sourceMappingURL=chunk-35S3GSRK.js.map
+//# sourceMappingURL=chunk-YXYGKTVB.js.map

package/dist/{chunk-GFXKYXHW.cjs → chunk-ZYSD6A2K.cjs}

@@ -189,10 +189,10 @@ var BIOMARKER_UNITS = {
   },
   Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
   Estradiol: {
-    // TODO: ng/dL ≠ pg/mL (1 ng/dL = 10 pg/mL) — display-only alias for now
-    aliases: { "ng/dl": "pg/mL", "pg/ml": "pg/mL" },
+    aliases: { "ng/dl": "ng/dL", "pg/ml": "pg/mL" },
     canonicalUcum: "pg/mL",
     canonicalUnit: "pg/mL",
+    molecularWeight: 272.38,
     siUcum: "pmol/L",
     siUnit: "pmol/L"
   },
@@ -343,8 +343,7 @@ var BIOMARKER_UNITS = {
   },
   RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
   TestosteroneFree: {
-    // TODO: pmol/L ≠ pg/mL (needs MW conversion) — display-only alias for now
-    aliases: { "pg/ml": "pg/mL", "pmol/l": "pg/mL" },
+    aliases: { "pg/ml": "pg/mL", "pmol/l": "pmol/L" },
     canonicalUcum: "pg/mL",
     canonicalUnit: "pg/mL",
     molecularWeight: 288.42,
@@ -423,6 +422,50 @@ function getCanonicalUnit(code) {
 function getSIUnit(code) {
   return _nullishCoalesce(_optionalChain([BIOMARKER_UNITS, 'access', _3 => _3[code], 'optionalAccess', _4 => _4.siUnit]), () => ( null));
 }
+function normalizeUnit(unit, config) {
+  return _nullishCoalesce(_nullishCoalesce(config.aliases[unit.toLowerCase()], () => ( config.aliases[unit])), () => ( unit));
+}
+var FIXED_FACTORS = {
+  "g/dL -> g/L": 10,
+  "g/L -> g/dL": 0.1,
+  "ng/dL -> pg/mL": 10,
+  "ng/mL -> \xB5g/L": 1,
+  "pg/mL -> ng/dL": 0.1,
+  "\xB5g/L -> ng/mL": 1
+};
+var MW_CONVERSIONS = {
+  "mg/dL -> mmol/L": { divideByMW: true, scale: 10 },
+  "mg/dL -> \xB5mol/L": { divideByMW: true, scale: 1e4 },
+  "mmol/L -> mg/dL": { divideByMW: false, scale: 10 },
+  "ng/dL -> nmol/L": { divideByMW: true, scale: 10 },
+  "ng/mL -> nmol/L": { divideByMW: true, scale: 1e3 },
+  "nmol/L -> ng/dL": { divideByMW: false, scale: 10 },
+  "nmol/L -> ng/mL": { divideByMW: false, scale: 1e3 },
+  "pg/mL -> pmol/L": { divideByMW: true, scale: 1e3 },
+  "pmol/L -> pg/mL": { divideByMW: false, scale: 1e3 },
+  "\xB5mol/L -> mg/dL": { divideByMW: false, scale: 1e4 }
+};
+function convertUnit(value, fromUnit, toUnit, biomarkerCode) {
+  const config = BIOMARKER_UNITS[biomarkerCode];
+  if (!config) return null;
+  const normFrom = normalizeUnit(fromUnit, config);
+  const normTo = normalizeUnit(toUnit, config);
+  if (normFrom === normTo) {
+    return { unit: normTo, value };
+  }
+  const key = `${normFrom} -> ${normTo}`;
+  const fixedFactor = FIXED_FACTORS[key];
+  if (fixedFactor !== void 0) {
+    return { unit: normTo, value: value * fixedFactor };
+  }
+  const mwConv = MW_CONVERSIONS[key];
+  if (mwConv && config.molecularWeight) {
+    const result = mwConv.divideByMW ? value * mwConv.scale / config.molecularWeight : value * config.molecularWeight / mwConv.scale;
+    return { unit: normTo, value: result };
+  }
+  return null;
+}
+
 
 
 
@@ -432,5 +475,5 @@ function getSIUnit(code) {
 
 
 
-exports.UNIT_TO_UCUM = UNIT_TO_UCUM; exports.BIOMARKER_DEFAULT_UNIT = BIOMARKER_DEFAULT_UNIT; exports.unitToUCUM = unitToUCUM; exports.getDefaultUnit = getDefaultUnit; exports.BIOMARKER_UNITS = BIOMARKER_UNITS; exports.getCanonicalUnit = getCanonicalUnit; exports.getSIUnit = getSIUnit;
-//# sourceMappingURL=chunk-GFXKYXHW.cjs.map
+exports.UNIT_TO_UCUM = UNIT_TO_UCUM; exports.BIOMARKER_DEFAULT_UNIT = BIOMARKER_DEFAULT_UNIT; exports.unitToUCUM = unitToUCUM; exports.getDefaultUnit = getDefaultUnit; exports.BIOMARKER_UNITS = BIOMARKER_UNITS; exports.getCanonicalUnit = getCanonicalUnit; exports.getSIUnit = getSIUnit; exports.convertUnit = convertUnit;
+//# sourceMappingURL=chunk-ZYSD6A2K.cjs.map

package/dist/chunk-ZYSD6A2K.cjs.map

@@ -0,0 +1 @@
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Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — 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siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'mIU/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'ng/dL -> pg/mL': 10,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return null;\n}\n"]}

package/dist/cli.js

@@ -2727,10 +2727,10 @@ var BIOMARKER_UNITS = {
   },
   Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
   Estradiol: {
-    // TODO: ng/dL ≠ pg/mL (1 ng/dL = 10 pg/mL) — display-only alias for now
-    aliases: { "ng/dl": "pg/mL", "pg/ml": "pg/mL" },
+    aliases: { "ng/dl": "ng/dL", "pg/ml": "pg/mL" },
     canonicalUcum: "pg/mL",
     canonicalUnit: "pg/mL",
+    molecularWeight: 272.38,
     siUcum: "pmol/L",
     siUnit: "pmol/L"
   },
@@ -2881,8 +2881,7 @@ var BIOMARKER_UNITS = {
   },
   RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
   TestosteroneFree: {
-    // TODO: pmol/L ≠ pg/mL (needs MW conversion) — display-only alias for now
-    aliases: { "pg/ml": "pg/mL", "pmol/l": "pg/mL" },
+    aliases: { "pg/ml": "pg/mL", "pmol/l": "pmol/L" },
     canonicalUcum: "pg/mL",
     canonicalUnit: "pg/mL",
     molecularWeight: 288.42,
@@ -5142,7 +5141,7 @@ async function range(args, json) {
   if (!ref) exitWithError(`Faixa de refer\xEAncia n\xE3o encontrada para: ${code}`);
   const direction = getRangeDirection(code);
   if (json) {
-    outputJson({ code, context: ctx, direction, range: ref });
+    outputJson({ ...def, context: ctx, direction, referenceRange: ref });
     return;
   }
   const sexLabel = ctx.biologicalSex === "M" ? "Homem" : ctx.biologicalSex === "F" ? "Mulher" : "Geral";
@@ -5170,22 +5169,21 @@ async function units(args, json) {
   const defaultUnit = getDefaultUnit(code) || def.unit || "";
   const canonical = getCanonicalUnit(code);
   const ucum = defaultUnit ? unitToUCUM(defaultUnit) : "";
-  const data = {
+  const unitDetails = {
     canonicalUnit: canonical ?? "\u2014",
-    code,
     defaultUnit,
     ucum: ucum || "\u2014"
   };
   if (json) {
-    outputJson(data);
+    outputJson({ ...def, ...unitDetails });
     return;
   }
   outputText(
     [
       `Unidades: ${code}`,
-      `  Padr\xE3o:    ${data.defaultUnit || "\u2014"}`,
-      `  Can\xF4nica:  ${data.canonicalUnit}`,
-      `  UCUM:      ${data.ucum}`
+      `  Padr\xE3o:    ${unitDetails.defaultUnit || "\u2014"}`,
+      `  Can\xF4nica:  ${unitDetails.canonicalUnit}`,
+      `  UCUM:      ${unitDetails.ucum}`
     ].join("\n")
   );
 }
@@ -5255,7 +5253,7 @@ async function main() {
     strict: false
   });
   if (values.version) {
-    process.stdout.write(`${"0.5.0"}
+    process.stdout.write(`${"0.6.0"}
 `);
     return;
   }

package/dist/converter.cjs

@@ -3,13 +3,13 @@
 
 
 
-var _chunk4EB4LIITcjs = require('./chunk-4EB4LIIT.cjs');
+var _chunkCPZ7YNONcjs = require('./chunk-CPZ7YNON.cjs');
 require('./chunk-2EVQ2ESB.cjs');
-require('./chunk-GFXKYXHW.cjs');
+require('./chunk-ZYSD6A2K.cjs');
 
 
 
 
 
-exports.labObservationToFHIR = _chunk4EB4LIITcjs.labObservationToFHIR; exports.labReportToFHIR = _chunk4EB4LIITcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunk4EB4LIITcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunk4EB4LIITcjs.userProfileToFHIR;
+exports.labObservationToFHIR = _chunkCPZ7YNONcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkCPZ7YNONcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkCPZ7YNONcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkCPZ7YNONcjs.userProfileToFHIR;
 //# sourceMappingURL=converter.cjs.map

package/dist/converter.js

@@ -3,9 +3,9 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-RGHKKL3W.js";
+} from "./chunk-4KGWSF55.js";
 import "./chunk-I6H35QXI.js";
-import "./chunk-VPMT4MRS.js";
+import "./chunk-R25V2E6S.js";
 export {
   labObservationToFHIR,
   labReportToFHIR,

package/dist/index.cjs

@@ -3,7 +3,7 @@
 
 
 
-var _chunk4EB4LIITcjs = require('./chunk-4EB4LIIT.cjs');
+var _chunkCPZ7YNONcjs = require('./chunk-CPZ7YNON.cjs');
 
 
 
@@ -51,7 +51,7 @@ var _chunk2EVQ2ESBcjs = require('./chunk-2EVQ2ESB.cjs');
 
 
 
-var _chunkZUBHCXUVcjs = require('./chunk-ZUBHCXUV.cjs');
+var _chunkLYDCZW4Ccjs = require('./chunk-LYDCZW4C.cjs');
 
 
 
@@ -60,7 +60,8 @@ var _chunkZUBHCXUVcjs = require('./chunk-ZUBHCXUV.cjs');
 
 
 
-var _chunkGFXKYXHWcjs = require('./chunk-GFXKYXHW.cjs');
+
+var _chunkZYSD6A2Kcjs = require('./chunk-ZYSD6A2K.cjs');
 
 
 
@@ -73,7 +74,7 @@ function interventionStatus(endDate) {
   return new Date(endDate) < /* @__PURE__ */ new Date() ? "completed" : "active";
 }
 var LIFESTYLE_CODES = {
-  diet: { code: "81259-4", display: "Associated precondition - Loss of appetite" },
+  diet: { code: "81259-4", display: "Diet" },
   exercise: { code: "73985-4", display: "Exercise activity" },
   sleep: { code: "93832-4", display: "Sleep duration" }
 };
@@ -151,7 +152,7 @@ function interventionToFHIRObservation(intervention, patientId) {
 }
 function interventionsToFHIRBundle(interventions, userProfile) {
   const patientId = userProfile.userId;
-  const fhirPatient = _chunk4EB4LIITcjs.userProfileToFHIR.call(void 0, userProfile);
+  const fhirPatient = _chunkCPZ7YNONcjs.userProfileToFHIR.call(void 0, userProfile);
   const entries = interventions.map((intervention) => {
     const isMedication = intervention.type === "medication" || intervention.type === "supplement";
     const resource = isMedication ? interventionToFHIRMedicationStatement(intervention, patientId) : interventionToFHIRObservation(intervention, patientId);
@@ -536,5 +537,6 @@ var pluralPhraseCount = (count, noun, adjective) => {
 
 
 
-exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_DEFAULT_UNIT = _chunkGFXKYXHWcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunk2EVQ2ESBcjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkGFXKYXHWcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.CAC_INDICATOR_CODES = _chunk2EVQ2ESBcjs.CAC_INDICATOR_CODES; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunk2EVQ2ESBcjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunk2EVQ2ESBcjs.DEXA_INDICATOR_CODES; exports.MAX_FILE_SIZE = _chunkO25F6G3Kcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkO25F6G3Kcjs.MAX_OBSERVATIONS; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkGFXKYXHWcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkZUBHCXUVcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkZUBHCXUVcjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.codeToLoinc = _chunk2EVQ2ESBcjs.codeToLoinc; exports.defaultReferenceRanges = _chunkZUBHCXUVcjs.defaultReferenceRanges; exports.extractObservationsFromBundle = _chunkO25F6G3Kcjs.extractObservationsFromBundle; exports.filterVisibleBiomarkers = _chunk2EVQ2ESBcjs.filterVisibleBiomarkers; exports.findCodeByName = _chunk2EVQ2ESBcjs.findCodeByName; exports.generateCacFullReference = _chunk2EVQ2ESBcjs.generateCacFullReference; exports.generateDexaFullReference = _chunk2EVQ2ESBcjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunk2EVQ2ESBcjs.generateFilteredLLMReference; exports.generateLLMReference = _chunk2EVQ2ESBcjs.generateLLMReference; exports.getAllCodes = _chunk2EVQ2ESBcjs.getAllCodes; exports.getAllDefinitions = _chunk2EVQ2ESBcjs.getAllDefinitions; exports.getAllLoincCodes = _chunk2EVQ2ESBcjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunk2EVQ2ESBcjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunk2EVQ2ESBcjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunk2EVQ2ESBcjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkGFXKYXHWcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkGFXKYXHWcjs.getDefaultUnit; exports.getDefinitionByCode = _chunk2EVQ2ESBcjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunk2EVQ2ESBcjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunk2EVQ2ESBcjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkZUBHCXUVcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkZUBHCXUVcjs.getRangeDirection; exports.getReferenceRange = _chunkZUBHCXUVcjs.getReferenceRange; exports.getSIUnit = _chunkGFXKYXHWcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunk2EVQ2ESBcjs.getSexForCode; exports.getVisibleDefinitions = _chunk2EVQ2ESBcjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunk2EVQ2ESBcjs.isBiomarkerVisible; exports.isCacDocument = _chunk2EVQ2ESBcjs.isCacDocument; exports.isDexaDocument = _chunk2EVQ2ESBcjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isValidCode = _chunk2EVQ2ESBcjs.isValidCode; exports.isValidLoinc = _chunk2EVQ2ESBcjs.isValidLoinc; exports.labObservationToFHIR = _chunk4EB4LIITcjs.labObservationToFHIR; exports.labReportToFHIR = _chunk4EB4LIITcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunk4EB4LIITcjs.labResultToFHIRBundle; exports.loincToCode = _chunk2EVQ2ESBcjs.loincToCode; exports.mapFHIRObservationToInternal = _chunkO25F6G3Kcjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunk2EVQ2ESBcjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunkO25F6G3Kcjs.processImportBundle; exports.toBiomarkerTests = _chunk2EVQ2ESBcjs.toBiomarkerTests; exports.unitToUCUM = _chunkGFXKYXHWcjs.unitToUCUM; exports.userProfileToFHIR = _chunk4EB4LIITcjs.userProfileToFHIR; exports.validateFHIRDiagnosticReport = _chunk3ILBFLVQcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunk3ILBFLVQcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunk3ILBFLVQcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunk2EVQ2ESBcjs.validateLoincNameMatch;
+
+exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_DEFAULT_UNIT = _chunkZYSD6A2Kcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunk2EVQ2ESBcjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkZYSD6A2Kcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.CAC_INDICATOR_CODES = _chunk2EVQ2ESBcjs.CAC_INDICATOR_CODES; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunk2EVQ2ESBcjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunk2EVQ2ESBcjs.DEXA_INDICATOR_CODES; exports.MAX_FILE_SIZE = _chunkO25F6G3Kcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkO25F6G3Kcjs.MAX_OBSERVATIONS; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkZYSD6A2Kcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkLYDCZW4Ccjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkLYDCZW4Ccjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.codeToLoinc = _chunk2EVQ2ESBcjs.codeToLoinc; exports.convertUnit = _chunkZYSD6A2Kcjs.convertUnit; exports.defaultReferenceRanges = _chunkLYDCZW4Ccjs.defaultReferenceRanges; exports.extractObservationsFromBundle = _chunkO25F6G3Kcjs.extractObservationsFromBundle; exports.filterVisibleBiomarkers = _chunk2EVQ2ESBcjs.filterVisibleBiomarkers; exports.findCodeByName = _chunk2EVQ2ESBcjs.findCodeByName; exports.generateCacFullReference = _chunk2EVQ2ESBcjs.generateCacFullReference; exports.generateDexaFullReference = _chunk2EVQ2ESBcjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunk2EVQ2ESBcjs.generateFilteredLLMReference; exports.generateLLMReference = _chunk2EVQ2ESBcjs.generateLLMReference; exports.getAllCodes = _chunk2EVQ2ESBcjs.getAllCodes; exports.getAllDefinitions = _chunk2EVQ2ESBcjs.getAllDefinitions; exports.getAllLoincCodes = _chunk2EVQ2ESBcjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunk2EVQ2ESBcjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunk2EVQ2ESBcjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunk2EVQ2ESBcjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkZYSD6A2Kcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkZYSD6A2Kcjs.getDefaultUnit; exports.getDefinitionByCode = _chunk2EVQ2ESBcjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunk2EVQ2ESBcjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunk2EVQ2ESBcjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkLYDCZW4Ccjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkLYDCZW4Ccjs.getRangeDirection; exports.getReferenceRange = _chunkLYDCZW4Ccjs.getReferenceRange; exports.getSIUnit = _chunkZYSD6A2Kcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunk2EVQ2ESBcjs.getSexForCode; exports.getVisibleDefinitions = _chunk2EVQ2ESBcjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunk2EVQ2ESBcjs.isBiomarkerVisible; exports.isCacDocument = _chunk2EVQ2ESBcjs.isCacDocument; exports.isDexaDocument = _chunk2EVQ2ESBcjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isValidCode = _chunk2EVQ2ESBcjs.isValidCode; exports.isValidLoinc = _chunk2EVQ2ESBcjs.isValidLoinc; exports.labObservationToFHIR = _chunkCPZ7YNONcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkCPZ7YNONcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkCPZ7YNONcjs.labResultToFHIRBundle; exports.loincToCode = _chunk2EVQ2ESBcjs.loincToCode; exports.mapFHIRObservationToInternal = _chunkO25F6G3Kcjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunk2EVQ2ESBcjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunkO25F6G3Kcjs.processImportBundle; exports.toBiomarkerTests = _chunk2EVQ2ESBcjs.toBiomarkerTests; exports.unitToUCUM = _chunkZYSD6A2Kcjs.unitToUCUM; exports.userProfileToFHIR = _chunkCPZ7YNONcjs.userProfileToFHIR; exports.validateFHIRDiagnosticReport = _chunk3ILBFLVQcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunk3ILBFLVQcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunk3ILBFLVQcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunk2EVQ2ESBcjs.validateLoincNameMatch;
 //# sourceMappingURL=index.cjs.map

package/dist/index.cjs.map

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* FHIR Intervention Converter\n *\n * Converts interventions (medication, supplement, diet, exercise, sleep)\n * to FHIR R4 MedicationStatement and Observation resources.\n */\n\nimport { userProfileToFHIR } from './converter';\nimport type { FHIRBundle, FHIRMedicationStatement, FHIRObservation } from './fhir-types';\nimport type { InterventionData, UserProfileData } from './types';\n\n/**\n * Determine MedicationStatement/Observation status based on end date\n */\nfunction interventionStatus(endDate?: string): 'active' | 'completed' {\n  if (!endDate) return 'active';\n  return new Date(endDate) < new Date() ? 'completed' : 'active';\n}\n\n/**\n * LOINC-like codes for lifestyle observation types\n */\nconst LIFESTYLE_CODES: Record<string, { code: string; display: string }> = {\n  diet: { code: '81259-4', display: 'Associated precondition - Loss of appetite' },\n  exercise: { code: '73985-4', display: 'Exercise activity' },\n  sleep: { code: '93832-4', display: 'Sleep duration' },\n};\n\n/**\n * Convert medication/supplement intervention to FHIR MedicationStatement\n */\nexport function interventionToFHIRMedicationStatement(\n  intervention: InterventionData,\n  patientId: string,\n): FHIRMedicationStatement {\n  const statement: FHIRMedicationStatement = {\n    category: {\n      coding: [\n        {\n          code: 'patientspecified',\n          display: 'Patient Specified',\n          system: 'http://terminology.hl7.org/CodeSystem/medication-statement-category',\n        },\n      ],\n    },\n    dateAsserted: intervention.startDate,\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    medicationCodeableConcept: {\n      text: intervention.name,\n    },\n    resourceType: 'MedicationStatement',\n    status: interventionStatus(intervention.endDate),\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n\n  if (intervention.notes) {\n    statement.note = [{ text: intervention.notes }];\n  }\n\n  return statement;\n}\n\n/**\n * Convert diet/exercise/sleep intervention to FHIR Observation (social-history)\n */\nexport function interventionToFHIRObservation(\n  intervention: InterventionData,\n  patientId: string,\n): FHIRObservation {\n  const lifestyleCode = LIFESTYLE_CODES[intervention.type];\n\n  const observation: FHIRObservation = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'social-history',\n            display: 'Social History',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      coding: lifestyleCode\n        ? [\n            {\n              code: lifestyleCode.code,\n              display: lifestyleCode.display,\n              system: 'http://loinc.org',\n            },\n          ]\n        : [],\n      text: intervention.name,\n    },\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    resourceType: 'Observation',\n    status: 'final',\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n    valueString: intervention.name,\n  };\n\n  if (intervention.notes) {\n    observation.note = [{ text: intervention.notes }];\n  }\n\n  return observation;\n}\n\n/**\n * Convert all interventions to a FHIR Bundle\n */\nexport function interventionsToFHIRBundle(\n  interventions: InterventionData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  const entries = interventions.map((intervention) => {\n    const isMedication = intervention.type === 'medication' || intervention.type === 'supplement';\n    const resource = isMedication\n      ? interventionToFHIRMedicationStatement(intervention, patientId)\n      : interventionToFHIRObservation(intervention, patientId);\n\n    return {\n      fullUrl: `urn:uuid:intervention-${intervention.interventionId}`,\n      resource,\n    };\n  });\n\n  return {\n    entry: [\n      {\n        fullUrl: `urn:uuid:${patientId}`,\n        resource: fhirPatient,\n      },\n      ...entries,\n    ],\n    resourceType: 'Bundle',\n    type: 'collection',\n  };\n}\n","/**\n * Structured zone data for DEXA body composition and bone density charts.\n *\n * Body fat zones derived from Gallagher et al. Am J Clin Nutr 2000;72:694-701 (PMID: 10966886)\n * and ACSM Guidelines for Exercise Testing, 11th Ed (2021).\n *\n * T-Score zones from WHO criteria (Kanis JA, Osteoporos Int, PMID: 7696835).\n */\n\nexport interface BodyFatZone {\n  ageMax: number;\n  ageMin: number;\n  color: string;\n  fatPctMax: number;\n  fatPctMin: number;\n  label: string;\n  sex: 'F' | 'M';\n}\n\ninterface AgeBracket {\n  ageMax: number;\n  ageMin: number;\n  label: string;\n}\n\nconst AGE_BRACKETS: AgeBracket[] = [\n  { ageMax: 25, ageMin: 18, label: '18-25' },\n  { ageMax: 35, ageMin: 26, label: '26-35' },\n  { ageMax: 45, ageMin: 36, label: '36-45' },\n  { ageMax: 55, ageMin: 46, label: '46-55' },\n  { ageMax: 99, ageMin: 56, label: '56+' },\n];\n\n// Zone boundaries per age bracket for men: [essential, athletic, fitness, average, obese]\n// Each value is the upper bound of the zone\nconst MALE_ZONES: number[][] = [\n  [5, 10, 20, 25, 40],\n  [5, 11, 21, 26, 40],\n  [5, 12, 22, 27, 40],\n  [5, 13, 23, 28, 40],\n  [5, 14, 24, 29, 40],\n];\n\nconst FEMALE_ZONES: number[][] = [\n  [13, 18, 28, 32, 45],\n  [13, 18, 29, 33, 45],\n  [13, 19, 30, 34, 45],\n  [13, 20, 31, 35, 45],\n  [13, 20, 32, 36, 45],\n];\n\ninterface ZoneDefinition {\n  color: string;\n  label: string;\n}\n\nconst ZONE_DEFS: ZoneDefinition[] = [\n  { color: '#3b82f6', label: 'Essencial' },\n  { color: '#06b6d4', label: 'Atlético' },\n  { color: '#22c55e', label: 'Fitness' },\n  { color: '#eab308', label: 'Média' },\n  { color: '#ef4444', label: 'Obeso' },\n];\n\nfunction buildZones(sex: 'F' | 'M', zoneData: number[][]): BodyFatZone[] {\n  const zones: BodyFatZone[] = [];\n  for (let i = 0; i < AGE_BRACKETS.length; i++) {\n    const bracket = AGE_BRACKETS[i]!;\n    const b = zoneData[i]!;\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[0]!.color,\n      fatPctMax: b[0]!,\n      fatPctMin: 0,\n      label: ZONE_DEFS[0]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[1]!.color,\n      fatPctMax: b[1]!,\n      fatPctMin: b[0]!,\n      label: ZONE_DEFS[1]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[2]!.color,\n      fatPctMax: b[2]!,\n      fatPctMin: b[1]!,\n      label: ZONE_DEFS[2]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[3]!.color,\n      fatPctMax: b[3]!,\n      fatPctMin: b[2]!,\n      label: ZONE_DEFS[3]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[4]!.color,\n      fatPctMax: b[4]!,\n      fatPctMin: b[3]!,\n      label: ZONE_DEFS[4]!.label,\n      sex,\n    });\n  }\n  return zones;\n}\n\nexport const BODY_FAT_ZONES: BodyFatZone[] = [\n  ...buildZones('M', MALE_ZONES),\n  ...buildZones('F', FEMALE_ZONES),\n];\n\nexport { AGE_BRACKETS, ZONE_DEFS };\n\nexport interface TScoreZone {\n  color: string;\n  label: string;\n  max: number;\n  min: number;\n}\n\nexport const T_SCORE_ZONES: TScoreZone[] = [\n  { color: '#22c55e', label: 'Normal', max: 4, min: -1.0 },\n  { color: '#eab308', label: 'Osteopenia', max: -1.0, min: -2.5 },\n  { color: '#ef4444', label: 'Osteoporose', max: -2.5, min: -5 },\n];\n","/**\n * Screening Intervals Configuration\n *\n * Defines recommended screening intervals for different biomarker categories\n * based on clinical guidelines and best practices.\n */\n\n/**\n * Screening interval in months\n */\nexport type ScreeningIntervalMonths = 3 | 6 | 12;\n\n/**\n * Biomarker category with its recommended screening interval\n */\nexport interface CategoryScreeningInterval {\n  category: string;\n  intervalMonths: ScreeningIntervalMonths;\n  nameEn: string;\n  namePt: string;\n}\n\n/**\n * Screening interval configuration for each category\n *\n * Categories are grouped by their recommended screening intervals:\n * - 3 months: Body composition and bone density (frequently changing metrics)\n * - 6 months: Metabolic panel and nutrients (moderate change rate)\n * - 12 months: Standard blood panels (stable long-term markers)\n */\nexport const CATEGORY_SCREENING_INTERVALS: CategoryScreeningInterval[] = [\n  // 3-month intervals - Body composition (frequently changing)\n  {\n    category: 'composicao-corporal',\n    intervalMonths: 3,\n    nameEn: 'Body Composition',\n    namePt: 'Composição Corporal',\n  },\n  {\n    category: 'densidade-ossea',\n    intervalMonths: 3,\n    nameEn: 'Bone Density',\n    namePt: 'Densidade Óssea',\n  },\n\n  // 6-month intervals - Metabolic and nutrients\n  {\n    category: 'metabolico',\n    intervalMonths: 6,\n    nameEn: 'Metabolic Panel',\n    namePt: 'Painel Metabólico',\n  },\n  {\n    category: 'nutrientes',\n    intervalMonths: 6,\n    nameEn: 'Nutrients',\n    namePt: 'Nutrientes',\n  },\n  {\n    category: 'pancreas',\n    intervalMonths: 6,\n    nameEn: 'Pancreas',\n    namePt: 'Pâncreas',\n  },\n\n  // 12-month intervals - Standard blood panels\n  {\n    category: 'coracao',\n    intervalMonths: 12,\n    nameEn: 'Heart Health',\n    namePt: 'Saúde Cardiovascular',\n  },\n  {\n    category: 'tireoide',\n    intervalMonths: 12,\n    nameEn: 'Thyroid',\n    namePt: 'Tireoide',\n  },\n  {\n    category: 'sangue',\n    intervalMonths: 12,\n    nameEn: 'Blood Count',\n    namePt: 'Hemograma',\n  },\n  {\n    category: 'figado',\n    intervalMonths: 12,\n    nameEn: 'Liver Function',\n    namePt: 'Função Hepática',\n  },\n  {\n    category: 'rins',\n    intervalMonths: 12,\n    nameEn: 'Kidney Function',\n    namePt: 'Função Renal',\n  },\n  {\n    category: 'saude-feminina',\n    intervalMonths: 12,\n    nameEn: \"Women's Health\",\n    namePt: 'Saúde Feminina',\n  },\n  {\n    category: 'saude-masculina',\n    intervalMonths: 12,\n    nameEn: \"Men's Health\",\n    namePt: 'Saúde Masculina',\n  },\n  {\n    category: 'eletrolitos',\n    intervalMonths: 12,\n    nameEn: 'Electrolytes',\n    namePt: 'Eletrólitos',\n  },\n  {\n    category: 'estresse-envelhecimento',\n    intervalMonths: 12,\n    nameEn: 'Stress & Aging',\n    namePt: 'Estresse e Envelhecimento',\n  },\n  {\n    category: 'autoimunidade',\n    intervalMonths: 12,\n    nameEn: 'Autoimmunity',\n    namePt: 'Autoimunidade',\n  },\n  {\n    category: 'regulacao-imunologica',\n    intervalMonths: 12,\n    nameEn: 'Immune Regulation',\n    namePt: 'Regulação Imunológica',\n  },\n  {\n    category: 'toxinas-ambientais',\n    intervalMonths: 12,\n    nameEn: 'Environmental Toxins',\n    namePt: 'Toxinas Ambientais',\n  },\n  {\n    category: 'urina',\n    intervalMonths: 12,\n    nameEn: 'Urinalysis',\n    namePt: 'Urina',\n  },\n];\n\n/**\n * Get screening interval for a category\n */\nexport const getScreeningInterval = (category: string): CategoryScreeningInterval | undefined => {\n  return CATEGORY_SCREENING_INTERVALS.find((c) => c.category === category);\n};\n\n/**\n * Get all categories with a specific interval\n */\nexport const getCategoriesByInterval = (\n  intervalMonths: ScreeningIntervalMonths,\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((c) => c.intervalMonths === intervalMonths);\n};\n\n/**\n * Calculate next screening date based on last test date and category\n */\nexport const calculateNextScreeningDate = (lastTestDate: Date, category: string): Date | null => {\n  const interval = getScreeningInterval(category);\n  if (!interval) return null;\n\n  const nextDate = new Date(lastTestDate);\n  nextDate.setMonth(nextDate.getMonth() + interval.intervalMonths);\n  return nextDate;\n};\n\n/**\n * Check if a category is due for screening\n */\nexport const isScreeningDue = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): boolean => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return false;\n  return referenceDate >= nextDate;\n};\n\n/**\n * Get categories that are due for screening based on last test dates\n */\nexport const getDueCategories = (\n  lastTestDates: Record<string, Date>,\n  referenceDate: Date = new Date(),\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((interval) => {\n    const lastDate = lastTestDates[interval.category];\n    if (!lastDate) return true; // Never tested = due\n    return isScreeningDue(lastDate, interval.category, referenceDate);\n  });\n};\n\n/**\n * Get days until next screening for a category\n */\nexport const getDaysUntilScreening = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): number | null => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return null;\n\n  const diffTime = nextDate.getTime() - referenceDate.getTime();\n  return Math.ceil(diffTime / (1000 * 60 * 60 * 24));\n};\n","/**\n * Portuguese pluralization utility using native Intl.PluralRules\n * Provides automatic pluralization for common words used in the app\n */\n\nconst pluralRules = new Intl.PluralRules('pt-BR');\n\n/**\n * Dictionary of Portuguese words with their plural forms\n * Key is the singular form, value is the plural form\n */\nconst dictionary: Record<string, string> = {\n  // Common nouns\n  arquivo: 'arquivos',\n  biomarcador: 'biomarcadores',\n  // Past participles (masculine)\n  cadastrado: 'cadastrados',\n  // Past participles (feminine)\n  concluída: 'concluídas',\n  confirmado: 'confirmados',\n  convertido: 'convertidos',\n  convidado: 'convidados',\n  convite: 'convites',\n  disponível: 'disponíveis',\n  documento: 'documentos',\n  enviado: 'enviados',\n  exame: 'exames',\n  excluída: 'excluídas',\n\n  excluído: 'excluídos',\n  // Verbs (3rd person)\n  falhou: 'falharam',\n  falta: 'faltam',\n  ignorado: 'ignorados',\n  item: 'itens',\n  outro: 'outros',\n  página: 'páginas',\n  pendente: 'pendentes',\n  registro: 'registros',\n  removido: 'removidos',\n\n  resultado: 'resultados',\n  revisão: 'revisões',\n\n  revogado: 'revogados',\n  usuário: 'usuários',\n};\n\n/**\n * Get the plural form of a word from the dictionary\n * Falls back to adding 's' if word is not in dictionary\n */\nconst getPluralForm = (singular: string): string => {\n  return dictionary[singular] ?? `${singular}s`;\n};\n\n/**\n * Returns the correct singular or plural form based on count\n * Uses Intl.PluralRules for proper locale-aware pluralization\n *\n * @example\n * plural(1, 'usuário') // 'usuário'\n * plural(3, 'usuário') // 'usuários'\n * plural(0, 'registro') // 'registros'\n */\nexport const plural = (count: number, word: string): string => {\n  const rule = pluralRules.select(count);\n  return rule === 'one' ? word : getPluralForm(word);\n};\n\n/**\n * Returns count with the correct singular or plural form\n *\n * @example\n * pluralCount(1, 'usuário') // '1 usuário'\n * pluralCount(3, 'usuário') // '3 usuários'\n */\nexport const pluralCount = (count: number, word: string): string => {\n  return `${count} ${plural(count, word)}`;\n};\n\n/**\n * Returns the correct form for compound phrases (noun + adjective)\n * Both words are pluralized together\n *\n * @example\n * pluralPhrase(1, 'usuário', 'cadastrado') // 'usuário cadastrado'\n * pluralPhrase(3, 'usuário', 'cadastrado') // 'usuários cadastrados'\n * pluralPhrase(2, 'revisão', 'excluída') // 'revisões excluídas'\n */\nexport const pluralPhrase = (count: number, noun: string, adjective: string): string => {\n  const rule = pluralRules.select(count);\n  if (rule === 'one') {\n    return `${noun} ${adjective}`;\n  }\n  return `${getPluralForm(noun)} ${getPluralForm(adjective)}`;\n};\n\n/**\n * Returns count with the correct compound phrase form\n *\n * @example\n * pluralPhraseCount(1, 'usuário', 'cadastrado') // '1 usuário cadastrado'\n * pluralPhraseCount(3, 'convite', 'enviado') // '3 convites enviados'\n */\nexport const pluralPhraseCount = (count: number, noun: string, adjective: string): string => {\n  return `${count} ${pluralPhrase(count, noun, adjective)}`;\n};\n"]}
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'completed' : 'active';\n}\n\n/**\n * LOINC-like codes for lifestyle observation types\n */\nconst LIFESTYLE_CODES: Record<string, { code: string; display: string }> = {\n  diet: { code: '81259-4', display: 'Diet' },\n  exercise: { code: '73985-4', display: 'Exercise activity' },\n  sleep: { code: '93832-4', display: 'Sleep duration' },\n};\n\n/**\n * Convert medication/supplement intervention to FHIR MedicationStatement\n */\nexport function interventionToFHIRMedicationStatement(\n  intervention: InterventionData,\n  patientId: string,\n): FHIRMedicationStatement {\n  const statement: FHIRMedicationStatement = {\n    category: {\n      coding: [\n        {\n          code: 'patientspecified',\n          display: 'Patient Specified',\n          system: 'http://terminology.hl7.org/CodeSystem/medication-statement-category',\n        },\n      ],\n    },\n    dateAsserted: intervention.startDate,\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    medicationCodeableConcept: {\n      text: intervention.name,\n    },\n    resourceType: 'MedicationStatement',\n    status: interventionStatus(intervention.endDate),\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n\n  if (intervention.notes) {\n    statement.note = [{ text: intervention.notes }];\n  }\n\n  return statement;\n}\n\n/**\n * Convert diet/exercise/sleep intervention to FHIR Observation (social-history)\n */\nexport function interventionToFHIRObservation(\n  intervention: InterventionData,\n  patientId: string,\n): FHIRObservation {\n  const lifestyleCode = LIFESTYLE_CODES[intervention.type];\n\n  const observation: FHIRObservation = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'social-history',\n            display: 'Social History',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      coding: lifestyleCode\n        ? [\n            {\n              code: lifestyleCode.code,\n              display: lifestyleCode.display,\n              system: 'http://loinc.org',\n            },\n          ]\n        : [],\n      text: intervention.name,\n    },\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    resourceType: 'Observation',\n    status: 'final',\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n    valueString: intervention.name,\n  };\n\n  if (intervention.notes) {\n    observation.note = [{ text: intervention.notes }];\n  }\n\n  return observation;\n}\n\n/**\n * Convert all interventions to a FHIR Bundle\n */\nexport function interventionsToFHIRBundle(\n  interventions: InterventionData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  const entries = interventions.map((intervention) => {\n    const isMedication = intervention.type === 'medication' || intervention.type === 'supplement';\n    const resource = isMedication\n      ? interventionToFHIRMedicationStatement(intervention, patientId)\n      : interventionToFHIRObservation(intervention, patientId);\n\n    return {\n      fullUrl: `urn:uuid:intervention-${intervention.interventionId}`,\n      resource,\n    };\n  });\n\n  return {\n    entry: [\n      {\n        fullUrl: `urn:uuid:${patientId}`,\n        resource: fhirPatient,\n      },\n      ...entries,\n    ],\n    resourceType: 'Bundle',\n    type: 'collection',\n  };\n}\n","/**\n * Structured zone data for DEXA body composition and bone density charts.\n *\n * Body fat zones derived from Gallagher et al. Am J Clin Nutr 2000;72:694-701 (PMID: 10966886)\n * and ACSM Guidelines for Exercise Testing, 11th Ed (2021).\n *\n * T-Score zones from WHO criteria (Kanis JA, Osteoporos Int, PMID: 7696835).\n */\n\nexport interface BodyFatZone {\n  ageMax: number;\n  ageMin: number;\n  color: string;\n  fatPctMax: number;\n  fatPctMin: number;\n  label: string;\n  sex: 'F' | 'M';\n}\n\ninterface AgeBracket {\n  ageMax: number;\n  ageMin: number;\n  label: string;\n}\n\nconst AGE_BRACKETS: AgeBracket[] = [\n  { ageMax: 25, ageMin: 18, label: '18-25' },\n  { ageMax: 35, ageMin: 26, label: '26-35' },\n  { ageMax: 45, ageMin: 36, label: '36-45' },\n  { ageMax: 55, ageMin: 46, label: '46-55' },\n  { ageMax: 99, ageMin: 56, label: '56+' },\n];\n\n// Zone boundaries per age bracket for men: [essential, athletic, fitness, average, obese]\n// Each value is the upper bound of the zone\nconst MALE_ZONES: number[][] = [\n  [5, 10, 20, 25, 40],\n  [5, 11, 21, 26, 40],\n  [5, 12, 22, 27, 40],\n  [5, 13, 23, 28, 40],\n  [5, 14, 24, 29, 40],\n];\n\nconst FEMALE_ZONES: number[][] = [\n  [13, 18, 28, 32, 45],\n  [13, 18, 29, 33, 45],\n  [13, 19, 30, 34, 45],\n  [13, 20, 31, 35, 45],\n  [13, 20, 32, 36, 45],\n];\n\ninterface ZoneDefinition {\n  color: string;\n  label: string;\n}\n\nconst ZONE_DEFS: ZoneDefinition[] = [\n  { color: '#3b82f6', label: 'Essencial' },\n  { color: '#06b6d4', label: 'Atlético' },\n  { color: '#22c55e', label: 'Fitness' },\n  { color: '#eab308', label: 'Média' },\n  { color: '#ef4444', label: 'Obeso' },\n];\n\nfunction buildZones(sex: 'F' | 'M', zoneData: number[][]): BodyFatZone[] {\n  const zones: BodyFatZone[] = [];\n  for (let i = 0; i < AGE_BRACKETS.length; i++) {\n    const bracket = AGE_BRACKETS[i]!;\n    const b = zoneData[i]!;\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[0]!.color,\n      fatPctMax: b[0]!,\n      fatPctMin: 0,\n      label: ZONE_DEFS[0]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[1]!.color,\n      fatPctMax: b[1]!,\n      fatPctMin: b[0]!,\n      label: ZONE_DEFS[1]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[2]!.color,\n      fatPctMax: b[2]!,\n      fatPctMin: b[1]!,\n      label: ZONE_DEFS[2]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[3]!.color,\n      fatPctMax: b[3]!,\n      fatPctMin: b[2]!,\n      label: ZONE_DEFS[3]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[4]!.color,\n      fatPctMax: b[4]!,\n      fatPctMin: b[3]!,\n      label: ZONE_DEFS[4]!.label,\n      sex,\n    });\n  }\n  return zones;\n}\n\nexport const BODY_FAT_ZONES: BodyFatZone[] = [\n  ...buildZones('M', MALE_ZONES),\n  ...buildZones('F', FEMALE_ZONES),\n];\n\nexport { AGE_BRACKETS, ZONE_DEFS };\n\nexport interface TScoreZone {\n  color: string;\n  label: string;\n  max: number;\n  min: number;\n}\n\nexport const T_SCORE_ZONES: TScoreZone[] = [\n  { color: '#22c55e', label: 'Normal', max: 4, min: -1.0 },\n  { color: '#eab308', label: 'Osteopenia', max: -1.0, min: -2.5 },\n  { color: '#ef4444', label: 'Osteoporose', max: -2.5, min: -5 },\n];\n","/**\n * Screening Intervals Configuration\n *\n * Defines recommended screening intervals for different biomarker categories\n * based on clinical guidelines and best practices.\n */\n\n/**\n * Screening interval in months\n */\nexport type ScreeningIntervalMonths = 3 | 6 | 12;\n\n/**\n * Biomarker category with its recommended screening interval\n */\nexport interface CategoryScreeningInterval {\n  category: string;\n  intervalMonths: ScreeningIntervalMonths;\n  nameEn: string;\n  namePt: string;\n}\n\n/**\n * Screening interval configuration for each category\n *\n * Categories are grouped by their recommended screening intervals:\n * - 3 months: Body composition and bone density (frequently changing metrics)\n * - 6 months: Metabolic panel and nutrients (moderate change rate)\n * - 12 months: Standard blood panels (stable long-term markers)\n */\nexport const CATEGORY_SCREENING_INTERVALS: CategoryScreeningInterval[] = [\n  // 3-month intervals - Body composition (frequently changing)\n  {\n    category: 'composicao-corporal',\n    intervalMonths: 3,\n    nameEn: 'Body Composition',\n    namePt: 'Composição Corporal',\n  },\n  {\n    category: 'densidade-ossea',\n    intervalMonths: 3,\n    nameEn: 'Bone Density',\n    namePt: 'Densidade Óssea',\n  },\n\n  // 6-month intervals - Metabolic and nutrients\n  {\n    category: 'metabolico',\n    intervalMonths: 6,\n    nameEn: 'Metabolic Panel',\n    namePt: 'Painel Metabólico',\n  },\n  {\n    category: 'nutrientes',\n    intervalMonths: 6,\n    nameEn: 'Nutrients',\n    namePt: 'Nutrientes',\n  },\n  {\n    category: 'pancreas',\n    intervalMonths: 6,\n    nameEn: 'Pancreas',\n    namePt: 'Pâncreas',\n  },\n\n  // 12-month intervals - Standard blood panels\n  {\n    category: 'coracao',\n    intervalMonths: 12,\n    nameEn: 'Heart Health',\n    namePt: 'Saúde Cardiovascular',\n  },\n  {\n    category: 'tireoide',\n    intervalMonths: 12,\n    nameEn: 'Thyroid',\n    namePt: 'Tireoide',\n  },\n  {\n    category: 'sangue',\n    intervalMonths: 12,\n    nameEn: 'Blood Count',\n    namePt: 'Hemograma',\n  },\n  {\n    category: 'figado',\n    intervalMonths: 12,\n    nameEn: 'Liver Function',\n    namePt: 'Função Hepática',\n  },\n  {\n    category: 'rins',\n    intervalMonths: 12,\n    nameEn: 'Kidney Function',\n    namePt: 'Função Renal',\n  },\n  {\n    category: 'saude-feminina',\n    intervalMonths: 12,\n    nameEn: \"Women's Health\",\n    namePt: 'Saúde Feminina',\n  },\n  {\n    category: 'saude-masculina',\n    intervalMonths: 12,\n    nameEn: \"Men's Health\",\n    namePt: 'Saúde Masculina',\n  },\n  {\n    category: 'eletrolitos',\n    intervalMonths: 12,\n    nameEn: 'Electrolytes',\n    namePt: 'Eletrólitos',\n  },\n  {\n    category: 'estresse-envelhecimento',\n    intervalMonths: 12,\n    nameEn: 'Stress & Aging',\n    namePt: 'Estresse e Envelhecimento',\n  },\n  {\n    category: 'autoimunidade',\n    intervalMonths: 12,\n    nameEn: 'Autoimmunity',\n    namePt: 'Autoimunidade',\n  },\n  {\n    category: 'regulacao-imunologica',\n    intervalMonths: 12,\n    nameEn: 'Immune Regulation',\n    namePt: 'Regulação Imunológica',\n  },\n  {\n    category: 'toxinas-ambientais',\n    intervalMonths: 12,\n    nameEn: 'Environmental Toxins',\n    namePt: 'Toxinas Ambientais',\n  },\n  {\n    category: 'urina',\n    intervalMonths: 12,\n    nameEn: 'Urinalysis',\n    namePt: 'Urina',\n  },\n];\n\n/**\n * Get screening interval for a category\n */\nexport const getScreeningInterval = (category: string): CategoryScreeningInterval | undefined => {\n  return CATEGORY_SCREENING_INTERVALS.find((c) => c.category === category);\n};\n\n/**\n * Get all categories with a specific interval\n */\nexport const getCategoriesByInterval = (\n  intervalMonths: ScreeningIntervalMonths,\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((c) => c.intervalMonths === intervalMonths);\n};\n\n/**\n * Calculate next screening date based on last test date and category\n */\nexport const calculateNextScreeningDate = (lastTestDate: Date, category: string): Date | null => {\n  const interval = getScreeningInterval(category);\n  if (!interval) return null;\n\n  const nextDate = new Date(lastTestDate);\n  nextDate.setMonth(nextDate.getMonth() + interval.intervalMonths);\n  return nextDate;\n};\n\n/**\n * Check if a category is due for screening\n */\nexport const isScreeningDue = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): boolean => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return false;\n  return referenceDate >= nextDate;\n};\n\n/**\n * Get categories that are due for screening based on last test dates\n */\nexport const getDueCategories = (\n  lastTestDates: Record<string, Date>,\n  referenceDate: Date = new Date(),\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((interval) => {\n    const lastDate = lastTestDates[interval.category];\n    if (!lastDate) return true; // Never tested = due\n    return isScreeningDue(lastDate, interval.category, referenceDate);\n  });\n};\n\n/**\n * Get days until next screening for a category\n */\nexport const getDaysUntilScreening = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): number | null => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return null;\n\n  const diffTime = nextDate.getTime() - referenceDate.getTime();\n  return Math.ceil(diffTime / (1000 * 60 * 60 * 24));\n};\n","/**\n * Portuguese pluralization utility using native Intl.PluralRules\n * Provides automatic pluralization for common words used in the app\n */\n\nconst pluralRules = new Intl.PluralRules('pt-BR');\n\n/**\n * Dictionary of Portuguese words with their plural forms\n * Key is the singular form, value is the plural form\n */\nconst dictionary: Record<string, string> = {\n  // Common nouns\n  arquivo: 'arquivos',\n  biomarcador: 'biomarcadores',\n  // Past participles (masculine)\n  cadastrado: 'cadastrados',\n  // Past participles (feminine)\n  concluída: 'concluídas',\n  confirmado: 'confirmados',\n  convertido: 'convertidos',\n  convidado: 'convidados',\n  convite: 'convites',\n  disponível: 'disponíveis',\n  documento: 'documentos',\n  enviado: 'enviados',\n  exame: 'exames',\n  excluída: 'excluídas',\n\n  excluído: 'excluídos',\n  // Verbs (3rd person)\n  falhou: 'falharam',\n  falta: 'faltam',\n  ignorado: 'ignorados',\n  item: 'itens',\n  outro: 'outros',\n  página: 'páginas',\n  pendente: 'pendentes',\n  registro: 'registros',\n  removido: 'removidos',\n\n  resultado: 'resultados',\n  revisão: 'revisões',\n\n  revogado: 'revogados',\n  usuário: 'usuários',\n};\n\n/**\n * Get the plural form of a word from the dictionary\n * Falls back to adding 's' if word is not in dictionary\n */\nconst getPluralForm = (singular: string): string => {\n  return dictionary[singular] ?? `${singular}s`;\n};\n\n/**\n * Returns the correct singular or plural form based on count\n * Uses Intl.PluralRules for proper locale-aware pluralization\n *\n * @example\n * plural(1, 'usuário') // 'usuário'\n * plural(3, 'usuário') // 'usuários'\n * plural(0, 'registro') // 'registros'\n */\nexport const plural = (count: number, word: string): string => {\n  const rule = pluralRules.select(count);\n  return rule === 'one' ? word : getPluralForm(word);\n};\n\n/**\n * Returns count with the correct singular or plural form\n *\n * @example\n * pluralCount(1, 'usuário') // '1 usuário'\n * pluralCount(3, 'usuário') // '3 usuários'\n */\nexport const pluralCount = (count: number, word: string): string => {\n  return `${count} ${plural(count, word)}`;\n};\n\n/**\n * Returns the correct form for compound phrases (noun + adjective)\n * Both words are pluralized together\n *\n * @example\n * pluralPhrase(1, 'usuário', 'cadastrado') // 'usuário cadastrado'\n * pluralPhrase(3, 'usuário', 'cadastrado') // 'usuários cadastrados'\n * pluralPhrase(2, 'revisão', 'excluída') // 'revisões excluídas'\n */\nexport const pluralPhrase = (count: number, noun: string, adjective: string): string => {\n  const rule = pluralRules.select(count);\n  if (rule === 'one') {\n    return `${noun} ${adjective}`;\n  }\n  return `${getPluralForm(noun)} ${getPluralForm(adjective)}`;\n};\n\n/**\n * Returns count with the correct compound phrase form\n *\n * @example\n * pluralPhraseCount(1, 'usuário', 'cadastrado') // '1 usuário cadastrado'\n * pluralPhraseCount(3, 'convite', 'enviado') // '3 convites enviados'\n */\nexport const pluralPhraseCount = (count: number, noun: string, adjective: string): string => {\n  return `${count} ${pluralPhrase(count, noun, adjective)}`;\n};\n"]}