@precisa-saude/fhir 0.38.0 → 0.38.1

package/dist/chunk-4WY5YFWA.cjs.map

@@ -1 +0,0 @@
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* Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\nimport { BIOMARKER_DEFINITIONS } from './biomarkers';\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Grafia impressa → código UCUM (Unified Code for Units of Measure).\n *\n * É a segunda fonte de `resolveUcum`, atrás de `BIOMARKER_UNITS`, e a única\n * para unidade que nenhum biomarcador configura. Cobre toda unidade declarada\n * em `biomarkers.ts`: o teste `loinc-axes.test.ts` confere isso, porque uma\n * unidade sem entrada aqui saía no FHIR como `code` sob o system do UCUM sem\n * ser UCUM (`uIU/mL`, `K/uL`, `razão`).\n *\n * `[IU]` e `[iU]` são o mesmo átomo no UCUM, nas grafias sensível e\n * insensível a caixa; esta tabela usa `[IU]` e `BIOMARKER_UNITS` usa `[iU]`.\n *\n * @see https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{index}': '{index}',\n  '{ratio}': '{ratio}',\n  '{score}': '{score}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/HPF': '/[HPF]',\n  '/LPF': '/[LPF]',\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  Angstrom: 'Ao',\n  AU: '{score}',\n  cm: 'cm',\n  'cm³': 'cm3',\n  deg: 'deg',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n  'g/cm²': 'g/cm2',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  'g/L': 'g/L',\n  'IU/L': '[IU]/L',\n  'IU/mL': '[IU]/mL',\n  'K/uL': '10*3/uL',\n  'kcal/d': 'kcal/d',\n  kg: 'kg',\n  'kg/m2': 'kg/m2',\n  'kg/m²': 'kg/m2',\n  'kU/L': 'k[IU]/L',\n  L: 'L',\n  'M/uL': '10*6/uL',\n  'mcg/dL': 'ug/dL',\n  'mcg/L': 'ug/L',\n  'mcg/mL': 'ug/mL',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  'mg/g': 'mg/g',\n  'mg/L': 'mg/L',\n  'mIU/L': 'm[IU]/L',\n  'mIU/mL': 'm[IU]/mL',\n  mL: 'mL',\n  'mL/min/1.73m²': 'mL/min/{1.73_m2}',\n  mm: 'mm',\n  'mm/h': 'mm/h',\n  'mm/hr': 'mm/h',\n  'mmol/L': 'mmol/L',\n  'mUI/L': 'm[IU]/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/L': 'ng/L',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  'pmol/L': 'pmol/L',\n  razão: '{ratio}',\n  score: '{score}',\n  segundos: 's',\n  // Enzyme activity\n  U: 'U',\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'ug/dL': 'ug/dL',\n  'ug/L': 'ug/L',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n  'uIU/mL': 'u[IU]/mL',\n  'umol/L': 'umol/L',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µg/L': 'ug/L',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n  índice: '{index}',\n};\n\n/**\n * Unidades adimensionais de urina, que a definição não declara porque o laudo\n * não as imprime: a densidade sai como `1.020` e o pH como `6.0`, sem unidade.\n * Quando o laudo não traz unidade, o FHIR ainda precisa de uma, e estas são\n * as do UCUM.\n */\nconst DIMENSIONLESS_DEFAULTS: Record<string, string> = {\n  pH_Urine: '[pH]',\n  SpecificGravity_Urine: '{specific gravity}',\n};\n\n/**\n * Unidade padrão de cada biomarcador, usada quando o laudo não imprime uma.\n *\n * Derivada de `unit` em `biomarkers.ts`, que é a fonte única. Até out/2026\n * era uma segunda tabela escrita à mão, e as duas divergiam: TSH era\n * `µUI/mL` aqui e `uIU/mL` lá, ferro era `µg/dL` aqui e `mcg/dL` lá. Duas\n * fontes para a mesma unidade é o que faz o `fhir-bio units` e o `fhir-bio\n * range` responderem coisas diferentes para o mesmo código.\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  ...Object.fromEntries(\n    BIOMARKER_DEFINITIONS.filter((b) => b.unit).map((b) => [b.code, b.unit as string]),\n  ),\n  ...DIMENSIONLESS_DEFAULTS,\n};\n\n/**\n * Convert unit to UCUM format\n *\n * Devolve a entrada intacta quando não conhece a unidade. Para montar um\n * `Quantity` FHIR use `resolveUcum`, que diz \"não sei\" em vez de devolver\n * uma grafia qualquer como se fosse UCUM.\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── UCUM syntax ─────────────────────────────────────────────────────────────\n\n/**\n * Átomos do UCUM que aparecem em laudo clínico, mais as bases do SI.\n *\n * Não é a tabela inteira do UCUM, que tem centenas de átomos. É a lista que\n * basta para dizer que `uIU/mL` não é UCUM (`IU` não é átomo; `[IU]` é) e que\n * `10*3/uL` é. Átomo fora desta lista cai em \"não é UCUM\", e o jeito certo de\n * aceitá-lo é acrescentá-lo aqui, com o laudo que o imprimiu.\n */\nconst UCUM_ATOMS = new Set([\n  'm',\n  'g',\n  's',\n  'L',\n  'l',\n  'mol',\n  'eq',\n  'U',\n  'cal',\n  'h',\n  'd',\n  'min',\n  'wk',\n  'mo',\n  'a',\n  'Ao',\n  'deg',\n  'K',\n  'A',\n  'N',\n  'Pa',\n  'J',\n  'W',\n  'Hz',\n  'V',\n  'C',\n  'osm',\n  't',\n  'u',\n  'bar',\n  'atm',\n  'rad',\n  'sr',\n  'cd',\n  'Bq',\n  'Gy',\n  'Sv',\n  'lm',\n  'lx',\n  'Cel',\n  'B',\n  'Np',\n]);\n\n/** Prefixos do UCUM, do yotta ao yocto. `da` (deca) é o único com duas letras. */\nconst UCUM_PREFIXES = new Set([\n  'Y',\n  'Z',\n  'E',\n  'P',\n  'T',\n  'G',\n  'M',\n  'k',\n  'h',\n  'da',\n  'd',\n  'c',\n  'm',\n  'u',\n  'n',\n  'p',\n  'f',\n  'a',\n  'z',\n  'y',\n]);\n\n/**\n * Um átomo com prefixo opcional: `g`, `mg`, `[IU]`, `u[IU]`, `10*3`, `%`.\n *\n * O prefixo só vale na frente de átomo métrico, e o UCUM marca essa\n * propriedade átomo a átomo. Aqui a regra é mais frouxa, prefixo na frente de\n * qualquer átomo, porque o que se quer pegar é grafia que não é UCUM de jeito\n * nenhum, e não o caso de borda `kdeg`.\n */\nfunction isUcumAtom(token: string): boolean {\n  if (token === '%' || /^10\\*-?\\d+$/.test(token) || /^\\d+$/.test(token)) return true;\n  // Átomo entre colchetes: `[IU]`, `[HPF]`, `[lb_av]`, `[pH]`. Com prefixo:\n  // `u[IU]`, `m[IU]`, `k[IU]`.\n  const bracket = /^([A-Za-z]{0,2})\\[[^[\\]{}\\s]+\\]$/.exec(token);\n  if (bracket) return bracket[1] === '' || UCUM_PREFIXES.has(bracket[1] as string);\n  if (UCUM_ATOMS.has(token)) return true;\n  for (const prefix of UCUM_PREFIXES) {\n    if (token.startsWith(prefix) && UCUM_ATOMS.has(token.slice(prefix.length))) return true;\n  }\n  return false;\n}\n\n/**\n * Um componente: átomo com expoente opcional e anotação opcional, ou anotação\n * sozinha. `m2`, `cm3`, `[in_i]3`, `mL{total}`, `{ratio}`.\n *\n * A anotação aceita qualquer caractere que não seja chave, que é o que a\n * especificação diz dela: texto sem interpretação. `{specific gravity}` passa\n * por isso, mesmo com espaço.\n */\nfunction isUcumComponent(token: string): boolean {\n  const m = /^(.*?)(\\{[^{}]*\\})?$/.exec(token);\n  if (!m) return false;\n  const [, body, annotation] = m;\n  if (!body) return annotation !== undefined;\n  const exp = /^(.+?)([+-]?\\d+)?$/.exec(body as string);\n  if (!exp) return false;\n  const [, atom, exponent] = exp;\n  // `10*3` termina em dígito e não tem expoente; o regex ganancioso já\n  // separou errado, então tenta o token inteiro como átomo primeiro.\n  if (isUcumAtom(body as string)) return true;\n  if (exponent === undefined) return false;\n  return isUcumAtom(atom as string);\n}\n\n/**\n * Diz se a string é sintaticamente UCUM: componentes ligados por `.` e `/`,\n * com `/` inicial permitido (`/[HPF]`).\n *\n * É sintaxe, não semântica: `K/uL` passa porque `K` é kelvin, e nada aqui sabe\n * que o laudo quis dizer milhares. É o que `resolveUcum` e `BIOMARKER_UNITS`\n * resolvem antes de a string chegar aqui. O que este check pega é o resto:\n * grafia em português, `µ` fora do ASCII, `IU` sem colchetes, `hr`.\n *\n * O `.` e o `/` só separam fora de chaves e colchetes: `mL/min/{1.73_m2}` tem\n * um ponto dentro da anotação, e `[in_i]` poderia ter um operador dentro do\n * átomo.\n */\nexport function isUcumCode(code: string): boolean {\n  if (!code || /[^\\x21-\\x7E ]/.test(code)) return false;\n  const terms: string[] = [];\n  let current = '';\n  let braces = 0;\n  let inBracket = false;\n  for (const ch of code) {\n    if (ch === '{') braces++;\n    else if (ch === '}') {\n      if (braces === 0) return false;\n      braces--;\n    } else if (ch === '[') inBracket = true;\n    else if (ch === ']') inBracket = false;\n    if ((ch === '.' || ch === '/') && braces === 0 && !inBracket) {\n      terms.push(current, ch);\n      current = '';\n      continue;\n    }\n    current += ch;\n  }\n  if (braces !== 0 || inBracket) return false;\n  terms.push(current);\n  // `/[HPF]` é `1/[HPF]` com o numerador implícito.\n  if (terms[0] === '' && terms[1] === '/') terms[0] = '1';\n\n  let expectOperand = true;\n  for (const t of terms) {\n    if (expectOperand) {\n      if (!isUcumComponent(t)) return false;\n    } else if (t !== '.' && t !== '/') {\n      return false;\n    }\n    expectOperand = !expectOperand;\n  }\n  return !expectOperand;\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\n/** Percentage biomarkers — canonical and SI both use %. */\nconst PERCENTAGE_ALIASES: Record<string, string> = { '%': '%', pct: '%', percent: '%' };\nconst PERCENTAGE: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '%',\n  canonicalUnit: '%',\n  siUcum: '%',\n  siUnit: '%',\n};\n\n/** Enzyme activity — canonical and SI both use U/L. */\nconst ENZYME_ALIASES: Record<string, string> = { 'iu/l': 'U/L', 'u/l': 'U/L' };\nconst ENZYME: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'U/L',\n  canonicalUnit: 'U/L',\n  siUcum: 'U/L',\n  siUnit: 'U/L',\n};\n\n/** Monovalent electrolytes — mEq/L ↔ mmol/L (1:1). */\nconst ELECTROLYTE_MONO_ALIASES: Record<string, string> = { 'meq/l': 'mEq/L', 'mmol/l': 'mmol/L' };\nconst ELECTROLYTE_MONO: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'meq/L',\n  canonicalUnit: 'mEq/L',\n  siUcum: 'mmol/L',\n  siUnit: 'mmol/L',\n};\n\n/** CAC scores — Agatston Units (AU), dimensionless. */\nconst CAC_ALIASES: Record<string, string> = { au: 'AU' };\nconst CAC: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '{score}',\n  canonicalUnit: 'AU',\n  siUcum: '{score}',\n  siUnit: 'AU',\n};\n\n/** nmol/L biomarkers — same unit for canonical and SI. */\nconst NMOL_L_ALIASES: Record<string, string> = { 'nmol/l': 'nmol/L' };\nconst NMOL_L: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'nmol/L',\n  canonicalUnit: 'nmol/L',\n  siUcum: 'nmol/L',\n  siUnit: 'nmol/L',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  AFP: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  ALT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AMH: {\n    aliases: { 'ng/ml': 'ng/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 12_500,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AntiTPO: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AoA1: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },\n  ApoB: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AST: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BilirubinDirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinIndirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinTotal: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  BMI: {\n    aliases: { 'kg/m2': 'kg/m²', 'kg/m²': 'kg/m²' },\n    canonicalUcum: 'kg/m2',\n    canonicalUnit: 'kg/m²',\n    siUcum: 'kg/m2',\n    siUnit: 'kg/m²',\n  },\n  BNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  // O BUN em mmol/L é expresso como ureia: cada molécula de ureia tem dois\n  // nitrogênios, então a massa que entra na conversão é a de N2 (2 × 14,007),\n  // e não a da ureia (60,06) usada em `Urea`. 14 mg/dL de BUN ≈ 5 mmol/L.\n  BUN: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 28.0134,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CA125: {\n    aliases: { 'u/ml': 'U/mL' },\n    canonicalUcum: 'U/mL',\n    canonicalUnit: 'U/mL',\n    siUcum: 'U/mL',\n    siUnit: 'U/mL',\n  },\n  CAC_LAD: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LCX: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LMA: { aliases: CAC_ALIASES, ...CAC },\n  CAC_RCA: { aliases: CAC_ALIASES, ...CAC },\n  Calcium: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 40.08,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CEA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CK: { aliases: ENZYME_ALIASES, ...ENZYME },\n  CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cortisol: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 362.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  DHEAS: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 368.49,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  DHT: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 290.44,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  ESR: {\n    aliases: { 'mm/h': 'mm/h', 'mm/hr': 'mm/h' },\n    canonicalUcum: 'mm/h',\n    canonicalUnit: 'mm/h',\n    siUcum: 'mm/h',\n    siUnit: 'mm/h',\n  },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  Folate: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 441.4,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  GGT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Globulin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Homocysteine: {\n    aliases: { 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'umol/L',\n    canonicalUnit: 'µmol/L',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  // Imunoglobulinas: canônica em mg/dL, a unidade da faixa de referência\n  // (Tietz) e a que laboratórios brasileiros e americanos imprimem. g/L fica\n  // como unidade SI; a conversão é exata (g/L × 100 = mg/dL, em FIXED_FACTORS).\n  IgA: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  IgG: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  INR: {\n    aliases: { '{ratio}': '{ratio}' },\n    canonicalUcum: '{ratio}',\n    canonicalUnit: '{ratio}',\n    siUcum: '{ratio}',\n    siUnit: '{ratio}',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Lead: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 207.2,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leptin: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCH: {\n    aliases: { pg: 'pg' },\n    canonicalUcum: 'pg',\n    canonicalUnit: 'pg',\n    siUcum: 'pg',\n    siUnit: 'pg',\n  },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  MCV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Mercury: {\n    aliases: { 'mcg/l': 'µg/L', 'nmol/l': 'nmol/L', 'ug/l': 'µg/L', 'µg/l': 'µg/L' },\n    canonicalUcum: 'ug/L',\n    canonicalUnit: 'µg/L',\n    molecularWeight: 200.59,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Microalbumin_Urine: {\n    aliases: { 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MPV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Myeloperoxidase: {\n    aliases: { 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pmol/L',\n    canonicalUnit: 'pmol/L',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,\n  // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.\n  NonHDL_Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  NTproBNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Progesterone: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 314.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  ProthrombinTime: {\n    aliases: { s: 's', sec: 's' },\n    canonicalUcum: 's',\n    canonicalUnit: 's',\n    siUcum: 's',\n    siUnit: 's',\n  },\n  PSA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  PSA_Free: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  RheumatoidFactor: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  T3Free: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 650.98,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Free: {\n    aliases: { 'ng/dl': 'ng/dL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 776.87,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Total: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 776.87,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Testosterone: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 288.42,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  TotalProtein: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TroponinI: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  // Troponina T: canônica em ng/L (hs-cTnT). O ensaio convencional imprime em\n  // ng/mL, que é a mesma grandeza que µg/L; converte por fator exato\n  // (ng/mL × 1000 = ng/L, em FIXED_FACTORS). pg/mL é a mesma unidade que ng/L\n  // e entra como alias, como em VitaminB12.\n  TroponinT: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/l': 'ng/L',\n      'ng/ml': 'ng/mL',\n      'pg/ml': 'ng/L',\n      'ug/l': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/L',\n    canonicalUnit: 'ng/L',\n    siUcum: 'ng/L',\n    siUnit: 'ng/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'm[iU]/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  UricAcid: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 168.11,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  VLDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'g/L -> mg/dL': 100,\n  'mEq/L -> mmol/L': 1,\n  'mg/dL -> g/L': 0.01,\n  'mmol/L -> mEq/L': 1,\n  'ng/dL -> pg/mL': 10,\n  'ng/L -> ng/mL': 0.001,\n  'ng/mL -> ng/L': 1000,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/dL -> pmol/L': { divideByMW: true, scale: 10_000 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'ng/mL -> pmol/L': { divideByMW: true, scale: 1_000_000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'nmol/L -> µg/dL': { divideByMW: false, scale: 10_000 },\n  'nmol/L -> µg/L': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> ng/dL': { divideByMW: false, scale: 10_000 },\n  'pmol/L -> ng/mL': { divideByMW: false, scale: 1_000_000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µg/dL -> nmol/L': { divideByMW: true, scale: 10_000 },\n  'µg/dL -> µmol/L': { divideByMW: true, scale: 10 },\n  'µg/L -> nmol/L': { divideByMW: true, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n  'µmol/L -> µg/dL': { divideByMW: false, scale: 10 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return null;\n}\n\n/**\n * Código UCUM para a unidade que o laudo imprimiu, ou `undefined`.\n *\n * Ordem: a configuração do biomarcador em `BIOMARKER_UNITS` (que já sabe que\n * `K/uL` de leucócito é `10*3/uL`), depois a tabela `UNIT_TO_UCUM`, e por\n * último a própria string, se for UCUM sintaticamente válido. Fora disso é\n * `undefined`, e o conversor deixa o `Quantity` só com `unit`: unidade que\n * não se sabe traduzir não sai sob `http://unitsofmeasure.org`.\n *\n * Até out/2026 o conversor só consultava a tabela e devolvia a entrada\n * intacta quando não achava, então `uIU/mL`, `K/uL` e `razão` saíam como\n * código UCUM, e os 85 `canonicalUcum` de `BIOMARKER_UNITS` não eram lidos\n * por ninguém fora de `units.ts`.\n */\nexport function resolveUcum(unit: string, biomarkerCode?: string): string | undefined {\n  if (!unit) return undefined;\n  const config = biomarkerCode ? BIOMARKER_UNITS[biomarkerCode] : undefined;\n  if (config) {\n    const normalized = normalizeUnit(unit, config);\n    if (normalized === config.canonicalUnit) return config.canonicalUcum;\n    if (normalized === config.siUnit) return config.siUcum;\n  }\n  const mapped = UNIT_TO_UCUM[unit];\n  if (mapped) return mapped;\n  return isUcumCode(unit) ? unit : undefined;\n}\n"]}

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* Registro de fontes bibliográficas para faixas de referência de biomarcadores.\n *\n * Exportado na API pública desde a 0.32: o campo `source` de cada faixa é uma\n * chave, e sem o registro ao lado ela não resolve para lugar nenhum. Quem\n * consome via `@precisa-saude/fhir/sources` ou pelo `fhir-bio source`.\n *\n * Todas as citações seguem o formato ABNT (NBR 6023).\n */\n\n/**\n * Referência bibliográfica completa para uma fonte de faixas de referência.\n */\nexport interface SourceReference {\n  /** Citação completa em formato ABNT (NBR 6023) */\n  abnt: string;\n  /** DOI, quando disponível */\n  doi?: string;\n  /** ISBN, quando aplicável */\n  isbn?: string;\n  /** Chave curta usada no campo `source` de BiomarkerRangeDefinition */\n  key: string;\n  /** URL de acesso */\n  url?: string;\n}\n\n/**\n * Registro central de todas as fontes bibliográficas utilizadas nas faixas de referência.\n *\n * Cada chave corresponde ao valor usado no campo `source` de `BiomarkerRangeDefinition`\n * (sem o sufixo de localização, ex: `'sbc-lipids-2017'` sem `':p15'`).\n */\nexport const SOURCE_REGISTRY: Record<string, SourceReference> = {\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Cardiovascular\n  // ---------------------------------------------------------------------------\n  'agatston-1990': {\n    abnt: 'AGATSTON, A. S. et al. Quantification of coronary artery calcium using ultrafast computed tomography. Journal of the American College of Cardiology, v. 15, n. 4, p. 827-832, 1990.',\n    doi: '10.1016/0735-1097(90)90282-T',\n    key: 'agatston-1990',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/2407762/',\n  },\n\n  'browning-ashwell-2010': {\n    abnt: 'BROWNING, L. M.; HSIEH, S. D.; ASHWELL, M. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0,5 could be a suitable global boundary value. Nutrition Research Reviews, v. 23, n. 2, p. 247-269, 2010.',\n    doi: '10.1017/S0954422410000144',\n    key: 'browning-ashwell-2010',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/20819243/',\n  },\n\n  'castelli-ratio-1992': {\n    abnt: 'CASTELLI, W. P. et al. Lipids and risk of coronary heart disease: the Framingham Study. Annals of Epidemiology, v. 2, n. 1-2, p. 23-28, 1992.',\n    doi: '10.1016/1047-2797(92)90033-M',\n    key: 'castelli-ratio-1992',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/1342260/',\n  },\n\n  'caulfield-ionmobility-2008': {\n    abnt: 'CAULFIELD, M. P. et al. Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clinical Chemistry, v. 54, n. 8, p. 1307-1316, 2008.',\n    doi: '10.1373/clinchem.2007.100586',\n    key: 'caulfield-ionmobility-2008',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/18515257/',\n  },\n\n  'contois-apoa1-1996': {\n    abnt: 'CONTOIS, J. H. et al. Reference intervals for plasma apolipoprotein A-1 determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study. Clinical Chemistry, v. 42, n. 4, p. 507-514, 1996.',\n    doi: '10.1093/clinchem/42.4.507',\n    key: 'contois-apoa1-1996',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/8605666/',\n  },\n\n  'ewgsop2-2019': {\n    abnt: 'CRUZ-JENTOFT, A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, v. 48, n. 1, p. 16-31, 2019.',\n    doi: '10.1093/ageing/afy169',\n    key: 'ewgsop2-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/30312372/',\n  },\n\n  'ferreira-vitd-2017': {\n    abnt: 'FERREIRA, C. E. S. et al. Posicionamento oficial da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial e da Sociedade Brasileira de Endocrinologia e Metabologia sobre intervalos de referência da vitamina D [25(OH)D]. Archives of Endocrinology and Metabolism, v. 61, n. 6, p. 527-542, 2017.',\n    doi: '10.1590/2359-3997000000310',\n    key: 'ferreira-vitd-2017',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/29412389/',\n  },\n\n  'friedewald-1972': {\n    abnt: 'FRIEDEWALD, W. T.; LEVY, R. I.; FREDRICKSON, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, v. 18, n. 6, p. 499-502, 1972.',\n    doi: '10.1093/clinchem/18.6.499',\n    key: 'friedewald-1972',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/4337382/',\n  },\n\n  'gallagher-bodyfat-2000': {\n    abnt: 'GALLAGHER, D. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. American Journal of Clinical Nutrition, v. 72, n. 3, p. 694-701, 2000.',\n    key: 'gallagher-bodyfat-2000',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10966886/',\n  },\n\n  'ge-corescan': {\n    abnt: 'GE HEALTHCARE. enCORE Software CoreScan: Visceral Adipose Tissue (VAT) assessment. Madison: GE Medical Systems Lunar, [s. d.]. (Documentação do fabricante do DEXA Lunar Prodigy; classificação Healthy 0–52 in³, Increased Risk 52,15–112,10 in³, At Risk 112,10+ in³, equivalente a 0–852 cm³, 854–1.837 cm³, 1.837+ cm³.)',\n    key: 'ge-corescan',\n    url: 'https://www.gehealthcare.com/products/bone-and-metabolic-health/encore',\n  },\n\n  'geloneze-brams-2009': {\n    abnt: 'GELONEZE, B. et al. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome — Brazilian Metabolic Syndrome Study (BRAMS). Arquivos Brasileiros de Endocrinologia & Metabologia, v. 53, n. 2, p. 281-287, 2009.',\n    doi: '10.1590/S0004-27302009000200020',\n    key: 'geloneze-brams-2009',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19466221/',\n  },\n\n  'george-ck-2016': {\n    abnt: 'GEORGE, M. D.; MCGILL, N. K.; BAKER, J. F. Creatine kinase in the U.S. population: impact of demographics, comorbidities, and body composition on the normal range. Medicine, v. 95, n. 33, e4344, 2016.',\n    doi: '10.1097/MD.0000000000004344',\n    key: 'george-ck-2016',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/27537560/',\n  },\n\n  'giannitsis-hstnt-2010': {\n    abnt: 'GIANNITSIS, E. et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clinical Chemistry, v. 56, n. 2, p. 254-261, 2010.',\n    doi: '10.1373/clinchem.2009.132654',\n    key: 'giannitsis-hstnt-2010',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19959623/',\n  },\n\n  'glis-2024': {\n    abnt: 'KIRK, B. et al. The conceptual definition of sarcopenia: Delphi consensus from the Global Leadership Initiative in Sarcopenia (GLIS). Age and Ageing, v. 53, n. 3, afae052, 2024.',\n    doi: '10.1093/ageing/afae052',\n    key: 'glis-2024',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/38520141/',\n  },\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Ácidos graxos ômega\n  // ---------------------------------------------------------------------------\n  'harris-omega3-2004': {\n    abnt: 'HARRIS, W. S.; VON SCHACKY, C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine, v. 39, n. 1, p. 212-220, 2004.',\n    doi: '10.1016/j.ypmed.2004.02.030',\n    key: 'harris-omega3-2004',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/15208005/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Referência laboratorial geral\n  // ---------------------------------------------------------------------------\n  'kalaria-ck-ri-2026': {\n    abnt: 'KALARIA, T. et al. Age, sex and ethnicity changes in creatine kinase and sex- and ethnicity-specific reference intervals of creatine kinase. Clinical Medicine, v. 26, n. 4, p. 100596, 2026.',\n    doi: '10.1016/j.clinme.2026.100596',\n    key: 'kalaria-ck-ri-2026',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/42142664/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Nefrologia\n  // ---------------------------------------------------------------------------\n  'kdigo-ckd-2024': {\n    abnt: 'KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International, v. 105, n. 4S, p. S117-S314, 2024.',\n    doi: '10.1016/j.kint.2023.10.018',\n    key: 'kdigo-ckd-2024',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/38490803/',\n  },\n\n  'keller-tni-2013': {\n    abnt: 'KELLER, T. et al. Defining a reference population to determine the 99th percentile of a contemporary sensitive cardiac troponin I assay. International Journal of Cardiology, v. 167, n. 4, p. 1423-1429, 2013.',\n    doi: '10.1016/j.ijcard.2012.04.063',\n    key: 'keller-tni-2013',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/22560907/',\n  },\n\n  'kelly-dxa-2009': {\n    abnt: 'KELLY, T. L. et al. Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS One, v. 4, n. 9, e7038, 2009.',\n    doi: '10.1371/journal.pone.0007038',\n    key: 'kelly-dxa-2009',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19753111/',\n  },\n\n  'khetarpal-apociii-2016': {\n    abnt: 'KHETARPAL, S. A. et al. Why is apolipoprotein CIII emerging as a novel therapeutic target to reduce the burden of cardiovascular disease? Current Atherosclerosis Reports, v. 18, n. 10, p. 59, 2016.',\n    key: 'khetarpal-apociii-2016',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC5018018/',\n  },\n\n  'klee-bhb-2020': {\n    abnt: 'KLEE, P. et al. Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples. Practical Laboratory Medicine, v. 18, e00146, 2020.',\n    doi: '10.1016/j.plabm.2019.e00146',\n    key: 'klee-bhb-2020',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC6999181/',\n  },\n\n  'maisel-bnp-2002': {\n    abnt: 'MAISEL, A. S. et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. New England Journal of Medicine, v. 347, n. 3, p. 161-167, 2002.',\n    doi: '10.1056/NEJMoa020233',\n    key: 'maisel-bnp-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12124404/',\n  },\n\n  'meuwese-mpo-2007': {\n    abnt: 'MEUWESE, M. C. et al. Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study. Journal of the American College of Cardiology, v. 50, n. 2, p. 159-165, 2007.',\n    doi: '10.1016/j.jacc.2007.03.033',\n    key: 'meuwese-mpo-2007',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/17616301/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Marcadores metabólicos e inflamatórios\n  // ---------------------------------------------------------------------------\n  'nemeth-adma-2017': {\n    abnt: 'NEMETH, B. et al. The issue of plasma asymmetric dimethylarginine reference range: a systematic review and meta-analysis. PLoS One, v. 12, n. 5, e0177493, 2017.',\n    doi: '10.1371/journal.pone.0177493',\n    key: 'nemeth-adma-2017',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/28494019/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes brasileiras — Metais pesados (NR-7)\n  // ---------------------------------------------------------------------------\n  'nr7-pcmso-2020': {\n    abnt: 'BRASIL. Ministério do Trabalho e Emprego. NR-7 — PCMSO, Quadro 1: Indicadores biológicos. Portaria n. 6.734, de 9 de março de 2020. Diário Oficial da União, Brasília, 13 mar. 2020.',\n    key: 'nr7-pcmso-2020',\n    url: 'https://www.gov.br/trabalho-e-emprego/pt-br/assuntos/inspecao-do-trabalho/seguranca-e-saude-no-trabalho/sst-portarias/2022/portaria-no-567-de-10-de-marco-de-2022-alteracoes-na-nr-7.pdf',\n  },\n\n  'ofenheimer-vat-2020': {\n    abnt: 'OFENHEIMER, A. et al. Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18-81 years: results from the LEAD cohort. European Journal of Clinical Nutrition, v. 74, p. 1181-1191, 2020.',\n    doi: '10.1038/s41430-020-0596-5',\n    key: 'ofenheimer-vat-2020',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/32123345/',\n  },\n\n  'pns-bioquimica-2019': {\n    abnt: 'SZWARCWALD, C. L. et al. Valores de referência para exames laboratoriais de colesterol, hemoglobina glicosilada e creatinina da população adulta brasileira. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190002.supl.2, 2019.',\n    doi: '10.1590/1980-549720190002.supl.2',\n    key: 'pns-bioquimica-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596373/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Pesquisa Nacional de Saúde (PNS) — Intervalos de referência brasileiros\n  // ---------------------------------------------------------------------------\n  'pns-hemograma-2019': {\n    abnt: 'ROSENFELD, L. G. et al. Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190003.supl.2, 2019.',\n    doi: '10.1590/1980-549720190003.supl.2',\n    key: 'pns-hemograma-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596374/',\n  },\n\n  'pns-renal-2019': {\n    abnt: 'MALTA, D. C. et al. Evaluation of renal function in the Brazilian adult population, according to laboratory criteria from the National Health Survey. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190010.supl.2, 2019.',\n    doi: '10.1590/1980-549720190010.supl.2',\n    key: 'pns-renal-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596381/',\n  },\n\n  'rumberger-cac-1999': {\n    abnt: 'RUMBERGER, J. A. et al. Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clinic Proceedings, v. 74, n. 3, p. 243-252, 1999.',\n    doi: '10.4065/74.3.243',\n    key: 'rumberger-cac-1999',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10089993/',\n  },\n\n  'sbc-ic-2018': {\n    abnt: 'ROHDE, L. E. P. et al. Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda. Arquivos Brasileiros de Cardiologia, São Paulo, v. 111, n. 3, p. 436-539, set. 2018.',\n    doi: '10.5935/abc.20180190',\n    key: 'sbc-ic-2018',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/30379264/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Cardiologia\n  // ---------------------------------------------------------------------------\n  'sbc-lipids-2017': {\n    abnt: 'FALUDI, A. A. et al. Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2017. Arquivos Brasileiros de Cardiologia, São Paulo, v. 109, n. 2, supl. 1, p. 1-76, ago. 2017.',\n    doi: '10.5935/abc.20170121',\n    key: 'sbc-lipids-2017',\n    url: 'https://www.scielo.br/j/abc/a/whBsCyzTDzGYJcsBY7YVkWn/?lang=pt',\n  },\n\n  'sbc-lipids-2025': {\n    abnt: 'RACHED, F. H. et al. Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2025. Arquivos Brasileiros de Cardiologia, São Paulo, v. 122, n. 9, e20250640, out. 2025.',\n    doi: '10.36660/abc.20250640',\n    key: 'sbc-lipids-2025',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC12674852/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Diabetes\n  // ---------------------------------------------------------------------------\n  'sbd-diabetes-2024': {\n    // Chave mantida como 'sbd-diabetes-2024' para compatibilidade com\n    // consumidores publicados; a diretriz correspondente é o documento vivo\n    // de diretriz.diabetes.org.br, cuja edição citada quando este registro foi\n    // atualizado é \"Edição 2025\". Semelhante ao caso de sbpc-ml-2021 abaixo.\n    abnt: 'SOCIEDADE BRASILEIRA DE DIABETES (SBD). Diretriz da Sociedade Brasileira de Diabetes — Edição 2025. São Paulo: SBD, 2025.',\n    doi: '10.29327/5660187',\n    isbn: '978-65-272-1932-3',\n    key: 'sbd-diabetes-2024',\n    url: 'https://diretriz.diabetes.org.br',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Endocrinologia e Metabologia\n  // ---------------------------------------------------------------------------\n  'sbem-thyroid-2013': {\n    abnt: 'SGARBI, J. A. et al. Consenso brasileiro para a abordagem clínica e tratamento do hipotireoidismo subclínico em adultos. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 57, n. 3, p. 166-183, 2013.',\n    doi: '10.1590/S0004-27302013000300003',\n    key: 'sbem-thyroid-2013',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/23681263/',\n  },\n  'sbem-vitamind-2014': {\n    abnt: 'MAEDA, S. S. et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 58, n. 5, p. 411-433, 2014.',\n    doi: '10.1590/0004-2730000003388',\n    key: 'sbem-vitamind-2014',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/25166032/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Patologia Clínica / Medicina Laboratorial\n  // ---------------------------------------------------------------------------\n  'sbpc-ml-2021': {\n    // Chave mantida como 'sbpc-ml-2021' para compatibilidade com consumidores;\n    // a edição autoritativa é de 2020 (verificada na Biblioteca Digital SBPC/ML\n    // em 2026-04-18). Ano na citação ABNT reflete a edição real.\n    abnt: 'SOCIEDADE BRASILEIRA DE PATOLOGIA CLÍNICA/MEDICINA LABORATORIAL (SBPC/ML). Recomendações da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML): Boas Práticas em Laboratório Clínico. São Paulo: SBPC/ML, 2020.',\n    key: 'sbpc-ml-2021',\n    url: 'https://bibliotecasbpc.org.br/index.php?P=4&C=0.2.443',\n  },\n\n  'schumann-ifcc-ldh-2002': {\n    abnt: 'SCHUMANN, G.; KLAUKE, R. New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects. Clinica Chimica Acta, v. 327, n. 1-2, p. 69-79, 2003.',\n    doi: '10.1016/S0009-8981(02)00341-8',\n    key: 'schumann-ifcc-ldh-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12482620/',\n  },\n\n  'schwedhelm-sdma-2011': {\n    abnt: 'SCHWEDHELM, E. et al. Plasma symmetric dimethylarginine reference limits from the Framingham Offspring Cohort. Clinical Chemistry and Laboratory Medicine, v. 49, n. 11, p. 1907-1910, 2011.',\n    doi: '10.1515/CCLM.2011.679',\n    key: 'schwedhelm-sdma-2011',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/21864208/',\n  },\n\n  'selhub-homocysteine-1999': {\n    abnt: 'SELHUB, J. et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Annals of Internal Medicine, v. 131, n. 5, p. 331-339, 1999.',\n    doi: '10.7326/0003-4819-131-5-199909070-00003',\n    key: 'selhub-homocysteine-1999',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10475885/',\n  },\n\n  'simopoulos-omega-ratio-2002': {\n    abnt: 'SIMOPOULOS, A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, v. 56, n. 8, p. 365-379, 2002.',\n    doi: '10.1016/S0753-3322(02)00253-6',\n    key: 'simopoulos-omega-ratio-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12442909/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Marcadores tumorais\n  // ---------------------------------------------------------------------------\n  'sturgeon-nacb-2008': {\n    abnt: 'STURGEON, C. M. et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clinical Chemistry, v. 54, n. 12, p. e11-e79, 2008.',\n    doi: '10.1373/clinchem.2008.105601',\n    key: 'sturgeon-nacb-2008',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19042984/',\n  },\n\n  'tietz-7ed-2015': {\n    abnt: 'BURTIS, C. A.; BRUNS, D. E. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. 7. ed. St. Louis: Elsevier Saunders, 2015.',\n    isbn: '978-1-4557-4165-6',\n    key: 'tietz-7ed-2015',\n  },\n\n  'torrissen-omega3-dbs-2025': {\n    abnt: 'TORRISSEN, M. et al. Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples. Lipids in Health and Disease, v. 24, n. 1, p. 260, 2025.',\n    doi: '10.1186/s12944-025-02676-6',\n    key: 'torrissen-omega3-dbs-2025',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/40783537/',\n  },\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Coagulação\n  // ---------------------------------------------------------------------------\n  'wells-ddimer-2003': {\n    abnt: 'WELLS, P. S. et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. New England Journal of Medicine, v. 349, p. 1227-1235, 2003.',\n    doi: '10.1056/NEJMoa023153',\n    key: 'wells-ddimer-2003',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/14507948/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — OMS\n  // ---------------------------------------------------------------------------\n  'who-iron-2020': {\n    abnt: 'WORLD HEALTH ORGANIZATION. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: WHO, 2020.',\n    isbn: '978-92-4-000012-4',\n    key: 'who-iron-2020',\n    url: 'https://www.who.int/publications/i/item/9789240000124',\n  },\n\n  'who-obesity-2000': {\n    abnt: 'WORLD HEALTH ORGANIZATION. Obesity: preventing and managing the global epidemic. WHO Technical Report Series, n. 894. Geneva: WHO, 2000.',\n    isbn: '92-4-120894-5',\n    key: 'who-obesity-2000',\n  },\n\n  'who-osteoporosis-1994': {\n    abnt: 'WHO STUDY GROUP. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series, n. 843. Geneva: WHO, 1994.',\n    key: 'who-osteoporosis-1994',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/7941614/',\n  },\n};\n\n/**\n * Extrai a chave de fonte de um valor `source` que pode conter localizador.\n *\n * @example\n * extractSourceKey('sbc-lipids-2017:p15') // 'sbc-lipids-2017'\n * extractSourceKey('sbpc-ml-2021')        // 'sbpc-ml-2021'\n */\nexport function extractSourceKey(source: string): string {\n  return source.split(':')[0] ?? source;\n}\n"]}