@precisa-saude/fhir 0.33.0 → 0.34.0

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- {"version":3,"sources":["../src/category-groups.ts","../src/intervention-converter.ts","../src/dexa-zone-data.ts","../src/screening-intervals.ts","../src/i18n.ts","../src/identifiers.ts","../src/extension-urls.ts","../src/specimen-types.ts"],"sourcesContent":["/**\n * Agrupamento de categorias clínicas em 10 grupos de alto nível.\n *\n * `BiomarkerDefinition.category` armazena 20 sub-categorias (granularidade\n * fina, ex: `tireoide`, `pancreas`). Este módulo agrupa essas\n * sub-categorias em 10 buckets clínicos amplos para apresentação no\n * site, na API pública e em material de divulgação.\n *\n * As sub-categorias permanecem como fonte da verdade nos dados; este\n * agrupamento é uma camada derivada.\n */\n\nexport type CategoryGroup =\n | 'cardiovascular'\n | 'metabolico-endocrino'\n | 'renal-eletrolitico'\n | 'hepatico-biliar'\n | 'hematologico'\n | 'imunologico'\n | 'oncologico'\n | 'nutricional-ambiental'\n | 'saude-reprodutiva'\n | 'composicao-envelhecimento';\n\nexport interface CategoryGroupInfo {\n /** Rótulo em inglês */\n en: string;\n /** Rótulo em português */\n pt: string;\n /** Slug (kebab-case, sem acento) */\n slug: CategoryGroup;\n /** Sub-categorias da fonte agrupadas neste bucket */\n subcategories: readonly string[];\n}\n\nexport const CATEGORY_GROUPS: Record<CategoryGroup, CategoryGroupInfo> = {\n cardiovascular: {\n en: 'Cardiovascular',\n pt: 'Cardiovascular',\n slug: 'cardiovascular',\n subcategories: ['coracao'],\n },\n 'composicao-envelhecimento': {\n en: 'Body Composition & Aging',\n pt: 'Composição Corporal e Envelhecimento',\n slug: 'composicao-envelhecimento',\n subcategories: ['composicao-corporal', 'densidade-ossea', 'estresse-envelhecimento'],\n },\n hematologico: {\n en: 'Hematology',\n pt: 'Hematológico',\n slug: 'hematologico',\n subcategories: ['sangue'],\n },\n 'hepatico-biliar': {\n en: 'Hepatic & Biliary',\n pt: 'Hepático e Biliar',\n slug: 'hepatico-biliar',\n subcategories: ['figado'],\n },\n imunologico: {\n en: 'Immunology',\n pt: 'Imunológico',\n slug: 'imunologico',\n subcategories: ['autoimunidade', 'regulacao-imunologica'],\n },\n 'metabolico-endocrino': {\n en: 'Metabolic & Endocrine',\n pt: 'Metabólico e Endócrino',\n slug: 'metabolico-endocrino',\n subcategories: ['metabolico', 'pancreas', 'hormonios', 'tireoide'],\n },\n 'nutricional-ambiental': {\n en: 'Nutrition & Environmental Exposure',\n pt: 'Nutricional e Exposição Ambiental',\n slug: 'nutricional-ambiental',\n subcategories: ['nutrientes', 'toxinas-ambientais'],\n },\n oncologico: {\n en: 'Oncology',\n pt: 'Oncológico',\n slug: 'oncologico',\n subcategories: ['marcadores-tumorais'],\n },\n 'renal-eletrolitico': {\n en: 'Renal & Electrolytes',\n pt: 'Renal e Eletrolítico',\n slug: 'renal-eletrolitico',\n subcategories: ['rins', 'urina', 'eletrolitos'],\n },\n 'saude-reprodutiva': {\n en: 'Reproductive Health',\n pt: 'Saúde Reprodutiva',\n slug: 'saude-reprodutiva',\n subcategories: ['saude-feminina', 'saude-masculina'],\n },\n};\n\nconst SUBCATEGORY_TO_GROUP = new Map<string, CategoryGroup>();\nfor (const group of Object.values(CATEGORY_GROUPS)) {\n for (const sub of group.subcategories) {\n SUBCATEGORY_TO_GROUP.set(sub, group.slug);\n }\n}\n\n/**\n * Resolve a sub-categoria (granular) para o grupo de alto nível (10 buckets).\n */\nexport function getCategoryGroup(subcategory: string): CategoryGroup | undefined {\n return SUBCATEGORY_TO_GROUP.get(subcategory);\n}\n\n/**\n * Lista todas as sub-categorias mapeadas em algum grupo.\n */\nexport function listMappedSubcategories(): readonly string[] {\n return [...SUBCATEGORY_TO_GROUP.keys()];\n}\n","/**\n * FHIR Intervention Converter\n *\n * Converts interventions (medication, supplement, diet, exercise, sleep)\n * to FHIR R4 MedicationStatement and Observation resources.\n */\n\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { userProfileToFHIR } from './converter';\nimport type { FHIRBundle, FHIRMedicationStatement, FHIRObservation } from './fhir-types';\nimport type { InterventionData, UserProfileData } from './types';\n\n/**\n * Determine MedicationStatement/Observation status based on end date\n */\nfunction interventionStatus(endDate?: string): 'active' | 'completed' {\n if (!endDate) return 'active';\n return new Date(endDate) < new Date() ? 'completed' : 'active';\n}\n\n/**\n * LOINC-like codes for lifestyle observation types\n */\nconst LIFESTYLE_CODES: Record<string, { code: string; display: string }> = {\n diet: { code: '81259-4', display: 'Diet' },\n exercise: { code: '73985-4', display: 'Exercise activity' },\n sleep: { code: '93832-4', display: 'Sleep duration' },\n};\n\n/**\n * Convert medication/supplement intervention to FHIR MedicationStatement\n */\nexport function interventionToFHIRMedicationStatement(\n intervention: InterventionData,\n patientId: string,\n): Addressable<FHIRMedicationStatement> {\n const statement: Addressable<FHIRMedicationStatement> = {\n category: {\n coding: [\n {\n code: 'patientspecified',\n display: 'Patient Specified',\n system: 'http://terminology.hl7.org/CodeSystem/medication-statement-category',\n },\n ],\n },\n dateAsserted: intervention.startDate,\n effectivePeriod: {\n end: intervention.endDate,\n start: intervention.startDate,\n },\n id: `intervention-${intervention.interventionId}`,\n medicationCodeableConcept: {\n text: intervention.name,\n },\n resourceType: 'MedicationStatement',\n status: interventionStatus(intervention.endDate),\n subject: {\n reference: `Patient/${patientId}`,\n },\n };\n\n if (intervention.notes) {\n statement.note = [{ text: intervention.notes }];\n }\n\n return statement;\n}\n\n/**\n * Convert diet/exercise/sleep intervention to FHIR Observation (social-history)\n */\nexport function interventionToFHIRObservation(\n intervention: InterventionData,\n patientId: string,\n): Addressable<FHIRObservation> {\n const lifestyleCode = LIFESTYLE_CODES[intervention.type];\n\n const observation: Addressable<FHIRObservation> = {\n category: [\n {\n coding: [\n {\n code: 'social-history',\n display: 'Social History',\n system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n },\n ],\n },\n ],\n code: {\n coding: lifestyleCode\n ? [\n {\n code: lifestyleCode.code,\n display: lifestyleCode.display,\n system: 'http://loinc.org',\n },\n ]\n : [],\n text: intervention.name,\n },\n effectivePeriod: {\n end: intervention.endDate,\n start: intervention.startDate,\n },\n id: `intervention-${intervention.interventionId}`,\n resourceType: 'Observation',\n status: 'final',\n subject: {\n reference: `Patient/${patientId}`,\n },\n valueString: intervention.name,\n };\n\n if (intervention.notes) {\n observation.note = [{ text: intervention.notes }];\n }\n\n return observation;\n}\n\n/**\n * Convert all interventions to a FHIR Bundle\n */\nexport function interventionsToFHIRBundle(\n interventions: InterventionData[],\n userProfile: UserProfileData,\n): FHIRBundle {\n const patientId = userProfile.userId;\n const fhirPatient = userProfileToFHIR(userProfile);\n\n const entries = interventions.map((intervention) => {\n const isMedication = intervention.type === 'medication' || intervention.type === 'supplement';\n const resource = isMedication\n ? interventionToFHIRMedicationStatement(intervention, patientId)\n : interventionToFHIRObservation(intervention, patientId);\n\n return { fullUrl: entryFullUrl(resource), resource };\n });\n\n return {\n entry: [{ fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient }, ...entries],\n resourceType: 'Bundle',\n type: 'collection',\n };\n}\n","/**\n * Structured zone data for DEXA body composition and bone density charts.\n *\n * Body fat zones derived from Gallagher et al. Am J Clin Nutr 2000;72:694-701 (PMID: 10966886)\n * and ACSM Guidelines for Exercise Testing, 11th Ed (2021).\n *\n * T-Score zones from WHO criteria (Kanis JA, Osteoporos Int, PMID: 7696835).\n */\n\nexport interface BodyFatZone {\n ageMax: number;\n ageMin: number;\n color: string;\n fatPctMax: number;\n fatPctMin: number;\n label: string;\n sex: 'F' | 'M';\n}\n\ninterface AgeBracket {\n ageMax: number;\n ageMin: number;\n label: string;\n}\n\nconst AGE_BRACKETS: AgeBracket[] = [\n { ageMax: 25, ageMin: 18, label: '18-25' },\n { ageMax: 35, ageMin: 26, label: '26-35' },\n { ageMax: 45, ageMin: 36, label: '36-45' },\n { ageMax: 55, ageMin: 46, label: '46-55' },\n { ageMax: 99, ageMin: 56, label: '56+' },\n];\n\n// Zone boundaries per age bracket for men: [essential, athletic, fitness, average, obese]\n// Each value is the upper bound of the zone\nconst MALE_ZONES: number[][] = [\n [5, 10, 20, 25, 40],\n [5, 11, 21, 26, 40],\n [5, 12, 22, 27, 40],\n [5, 13, 23, 28, 40],\n [5, 14, 24, 29, 40],\n];\n\nconst FEMALE_ZONES: number[][] = [\n [13, 18, 28, 32, 45],\n [13, 18, 29, 33, 45],\n [13, 19, 30, 34, 45],\n [13, 20, 31, 35, 45],\n [13, 20, 32, 36, 45],\n];\n\ninterface ZoneDefinition {\n color: string;\n label: string;\n}\n\nconst ZONE_DEFS: ZoneDefinition[] = [\n { color: '#3b82f6', label: 'Essencial' },\n { color: '#06b6d4', label: 'Atlético' },\n { color: '#22c55e', label: 'Fitness' },\n { color: '#eab308', label: 'Média' },\n { color: '#ef4444', label: 'Obeso' },\n];\n\nfunction buildZones(sex: 'F' | 'M', zoneData: number[][]): BodyFatZone[] {\n const zones: BodyFatZone[] = [];\n for (let i = 0; i < AGE_BRACKETS.length; i++) {\n const bracket = AGE_BRACKETS[i]!;\n const b = zoneData[i]!;\n zones.push({\n ...bracket,\n color: ZONE_DEFS[0]!.color,\n fatPctMax: b[0]!,\n fatPctMin: 0,\n label: ZONE_DEFS[0]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[1]!.color,\n fatPctMax: b[1]!,\n fatPctMin: b[0]!,\n label: ZONE_DEFS[1]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[2]!.color,\n fatPctMax: b[2]!,\n fatPctMin: b[1]!,\n label: ZONE_DEFS[2]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[3]!.color,\n fatPctMax: b[3]!,\n fatPctMin: b[2]!,\n label: ZONE_DEFS[3]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[4]!.color,\n fatPctMax: b[4]!,\n fatPctMin: b[3]!,\n label: ZONE_DEFS[4]!.label,\n sex,\n });\n }\n return zones;\n}\n\nexport const BODY_FAT_ZONES: BodyFatZone[] = [\n ...buildZones('M', MALE_ZONES),\n ...buildZones('F', FEMALE_ZONES),\n];\n\nexport { AGE_BRACKETS, ZONE_DEFS };\n\nexport interface TScoreZone {\n color: string;\n label: string;\n max: number;\n min: number;\n}\n\nexport const T_SCORE_ZONES: TScoreZone[] = [\n { color: '#22c55e', label: 'Normal', max: 4, min: -1.0 },\n { color: '#eab308', label: 'Osteopenia', max: -1.0, min: -2.5 },\n { color: '#ef4444', label: 'Osteoporose', max: -2.5, min: -5 },\n];\n","/**\n * Screening Intervals Configuration\n *\n * Defines recommended screening intervals for different biomarker categories\n * based on clinical guidelines and best practices.\n */\n\n/**\n * Screening interval in months\n */\nexport type ScreeningIntervalMonths = 3 | 6 | 12;\n\n/**\n * Biomarker category with its recommended screening interval\n */\nexport interface CategoryScreeningInterval {\n category: string;\n intervalMonths: ScreeningIntervalMonths;\n nameEn: string;\n namePt: string;\n}\n\n/**\n * Screening interval configuration for each category\n *\n * Categories are grouped by their recommended screening intervals:\n * - 3 months: Body composition and bone density (frequently changing metrics)\n * - 6 months: Metabolic panel and nutrients (moderate change rate)\n * - 12 months: Standard blood panels (stable long-term markers)\n */\nexport const CATEGORY_SCREENING_INTERVALS: CategoryScreeningInterval[] = [\n // 3-month intervals - Body composition (frequently changing)\n {\n category: 'composicao-corporal',\n intervalMonths: 3,\n nameEn: 'Body Composition',\n namePt: 'Composição Corporal',\n },\n {\n category: 'densidade-ossea',\n intervalMonths: 3,\n nameEn: 'Bone Density',\n namePt: 'Densidade Óssea',\n },\n\n // 6-month intervals - Metabolic and nutrients\n {\n category: 'metabolico',\n intervalMonths: 6,\n nameEn: 'Metabolic Panel',\n namePt: 'Painel Metabólico',\n },\n {\n category: 'nutrientes',\n intervalMonths: 6,\n nameEn: 'Nutrients',\n namePt: 'Nutrientes',\n },\n {\n category: 'pancreas',\n intervalMonths: 6,\n nameEn: 'Pancreas',\n namePt: 'Pâncreas',\n },\n\n // 12-month intervals - Standard blood panels\n {\n category: 'coracao',\n intervalMonths: 12,\n nameEn: 'Heart Health',\n namePt: 'Saúde Cardiovascular',\n },\n {\n category: 'tireoide',\n intervalMonths: 12,\n nameEn: 'Thyroid',\n namePt: 'Tireoide',\n },\n {\n category: 'sangue',\n intervalMonths: 12,\n nameEn: 'Blood Count',\n namePt: 'Hemograma',\n },\n {\n category: 'figado',\n intervalMonths: 12,\n nameEn: 'Liver Function',\n namePt: 'Função Hepática',\n },\n {\n category: 'rins',\n intervalMonths: 12,\n nameEn: 'Kidney Function',\n namePt: 'Função Renal',\n },\n {\n category: 'saude-feminina',\n intervalMonths: 12,\n nameEn: \"Women's Health\",\n namePt: 'Saúde Feminina',\n },\n {\n category: 'saude-masculina',\n intervalMonths: 12,\n nameEn: \"Men's Health\",\n namePt: 'Saúde Masculina',\n },\n {\n category: 'eletrolitos',\n intervalMonths: 12,\n nameEn: 'Electrolytes',\n namePt: 'Eletrólitos',\n },\n {\n category: 'estresse-envelhecimento',\n intervalMonths: 12,\n nameEn: 'Stress & Aging',\n namePt: 'Estresse e Envelhecimento',\n },\n {\n category: 'autoimunidade',\n intervalMonths: 12,\n nameEn: 'Autoimmunity',\n namePt: 'Autoimunidade',\n },\n {\n category: 'regulacao-imunologica',\n intervalMonths: 12,\n nameEn: 'Immune Regulation',\n namePt: 'Regulação Imunológica',\n },\n {\n category: 'toxinas-ambientais',\n intervalMonths: 12,\n nameEn: 'Environmental Toxins',\n namePt: 'Toxinas Ambientais',\n },\n {\n category: 'urina',\n intervalMonths: 12,\n nameEn: 'Urinalysis',\n namePt: 'Urina',\n },\n];\n\n/**\n * Get screening interval for a category\n */\nexport const getScreeningInterval = (category: string): CategoryScreeningInterval | undefined => {\n return CATEGORY_SCREENING_INTERVALS.find((c) => c.category === category);\n};\n\n/**\n * Get all categories with a specific interval\n */\nexport const getCategoriesByInterval = (\n intervalMonths: ScreeningIntervalMonths,\n): CategoryScreeningInterval[] => {\n return CATEGORY_SCREENING_INTERVALS.filter((c) => c.intervalMonths === intervalMonths);\n};\n\n/**\n * Calculate next screening date based on last test date and category\n */\nexport const calculateNextScreeningDate = (lastTestDate: Date, category: string): Date | null => {\n const interval = getScreeningInterval(category);\n if (!interval) return null;\n\n const nextDate = new Date(lastTestDate);\n nextDate.setMonth(nextDate.getMonth() + interval.intervalMonths);\n return nextDate;\n};\n\n/**\n * Check if a category is due for screening\n */\nexport const isScreeningDue = (\n lastTestDate: Date,\n category: string,\n referenceDate: Date = new Date(),\n): boolean => {\n const nextDate = calculateNextScreeningDate(lastTestDate, category);\n if (!nextDate) return false;\n return referenceDate >= nextDate;\n};\n\n/**\n * Get categories that are due for screening based on last test dates\n */\nexport const getDueCategories = (\n lastTestDates: Record<string, Date>,\n referenceDate: Date = new Date(),\n): CategoryScreeningInterval[] => {\n return CATEGORY_SCREENING_INTERVALS.filter((interval) => {\n const lastDate = lastTestDates[interval.category];\n if (!lastDate) return true; // Never tested = due\n return isScreeningDue(lastDate, interval.category, referenceDate);\n });\n};\n\n/**\n * Get days until next screening for a category\n */\nexport const getDaysUntilScreening = (\n lastTestDate: Date,\n category: string,\n referenceDate: Date = new Date(),\n): number | null => {\n const nextDate = calculateNextScreeningDate(lastTestDate, category);\n if (!nextDate) return null;\n\n const diffTime = nextDate.getTime() - referenceDate.getTime();\n return Math.ceil(diffTime / (1000 * 60 * 60 * 24));\n};\n","/**\n * Portuguese pluralization utility using native Intl.PluralRules\n * Provides automatic pluralization for common words used in the app\n */\n\nconst pluralRules = new Intl.PluralRules('pt-BR');\n\n/**\n * Dictionary of Portuguese words with their plural forms\n * Key is the singular form, value is the plural form\n */\nconst dictionary: Record<string, string> = {\n // Common nouns\n arquivo: 'arquivos',\n biomarcador: 'biomarcadores',\n // Past participles (masculine)\n cadastrado: 'cadastrados',\n // Past participles (feminine)\n concluída: 'concluídas',\n confirmado: 'confirmados',\n convertido: 'convertidos',\n convidado: 'convidados',\n convite: 'convites',\n disponível: 'disponíveis',\n documento: 'documentos',\n enviado: 'enviados',\n exame: 'exames',\n excluída: 'excluídas',\n\n excluído: 'excluídos',\n // Verbs (3rd person)\n falhou: 'falharam',\n falta: 'faltam',\n ignorado: 'ignorados',\n item: 'itens',\n outro: 'outros',\n página: 'páginas',\n pendente: 'pendentes',\n registro: 'registros',\n removido: 'removidos',\n\n resultado: 'resultados',\n revisão: 'revisões',\n\n revogado: 'revogados',\n usuário: 'usuários',\n};\n\n/**\n * Get the plural form of a word from the dictionary\n * Falls back to adding 's' if word is not in dictionary\n */\nconst getPluralForm = (singular: string): string => {\n return dictionary[singular] ?? `${singular}s`;\n};\n\n/**\n * Returns the correct singular or plural form based on count\n * Uses Intl.PluralRules for proper locale-aware pluralization\n *\n * @example\n * plural(1, 'usuário') // 'usuário'\n * plural(3, 'usuário') // 'usuários'\n * plural(0, 'registro') // 'registros'\n */\nexport const plural = (count: number, word: string): string => {\n const rule = pluralRules.select(count);\n return rule === 'one' ? word : getPluralForm(word);\n};\n\n/**\n * Returns count with the correct singular or plural form\n *\n * @example\n * pluralCount(1, 'usuário') // '1 usuário'\n * pluralCount(3, 'usuário') // '3 usuários'\n */\nexport const pluralCount = (count: number, word: string): string => {\n return `${count} ${plural(count, word)}`;\n};\n\n/**\n * Returns the correct form for compound phrases (noun + adjective)\n * Both words are pluralized together\n *\n * @example\n * pluralPhrase(1, 'usuário', 'cadastrado') // 'usuário cadastrado'\n * pluralPhrase(3, 'usuário', 'cadastrado') // 'usuários cadastrados'\n * pluralPhrase(2, 'revisão', 'excluída') // 'revisões excluídas'\n */\nexport const pluralPhrase = (count: number, noun: string, adjective: string): string => {\n const rule = pluralRules.select(count);\n if (rule === 'one') {\n return `${noun} ${adjective}`;\n }\n return `${getPluralForm(noun)} ${getPluralForm(adjective)}`;\n};\n\n/**\n * Returns count with the correct compound phrase form\n *\n * @example\n * pluralPhraseCount(1, 'usuário', 'cadastrado') // '1 usuário cadastrado'\n * pluralPhraseCount(3, 'convite', 'enviado') // '3 convites enviados'\n */\nexport const pluralPhraseCount = (count: number, noun: string, adjective: string): string => {\n return `${count} ${pluralPhrase(count, noun, adjective)}`;\n};\n","/**\n * Helpers para identificadores brasileiros — CPF e CNS\n *\n * Validação, formatação e conversão para FHIR Identifier.\n * Algoritmos de validação baseados nas especificações oficiais:\n * - CPF: Receita Federal (mod-11, dois dígitos verificadores)\n * - CNS: Ministério da Saúde (mod-11 para definitivos, soma ponderada para provisórios)\n */\n\nimport type { FHIRIdentifier } from './fhir-types';\n\nconst CPF_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cpf';\nconst CNS_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cns';\n\n/**\n * Remove caracteres não-numéricos de uma string.\n */\nfunction digitsOnly(value: string): string {\n return value.replace(/\\D/g, '');\n}\n\n/**\n * Valida um CPF brasileiro usando algoritmo mod-11.\n *\n * @param cpf — CPF com ou sem formatação (ex: \"123.456.789-09\" ou \"12345678909\")\n * @returns true se o CPF é estruturalmente válido\n */\nexport function validateCPF(cpf: string): boolean {\n const digits = digitsOnly(cpf);\n\n if (digits.length !== 11) return false;\n\n // Rejeitar sequências de dígitos iguais (ex: 111.111.111-11)\n if (/^(\\d)\\1{10}$/.test(digits)) return false;\n\n // Primeiro dígito verificador\n let sum = 0;\n for (let i = 0; i < 9; i++) {\n sum += Number(digits[i]) * (10 - i);\n }\n let remainder = (sum * 10) % 11;\n if (remainder === 10) remainder = 0;\n if (remainder !== Number(digits[9])) return false;\n\n // Segundo dígito verificador\n sum = 0;\n for (let i = 0; i < 10; i++) {\n sum += Number(digits[i]) * (11 - i);\n }\n remainder = (sum * 10) % 11;\n if (remainder === 10) remainder = 0;\n if (remainder !== Number(digits[10])) return false;\n\n return true;\n}\n\n/**\n * Valida um CNS (Cartão Nacional de Saúde) brasileiro.\n *\n * CNS definitivos começam com 1 ou 2 (mod-11).\n * CNS provisórios começam com 7, 8 ou 9 (soma ponderada mod-11 = 0).\n *\n * @param cns — CNS com 15 dígitos\n * @returns true se o CNS é estruturalmente válido\n */\nexport function validateCNS(cns: string): boolean {\n const digits = digitsOnly(cns);\n\n if (digits.length !== 15) return false;\n\n const firstDigit = digits[0]!;\n\n // CNS deve começar com 1, 2 (definitivo) ou 7, 8, 9 (provisório)\n if (!['1', '2', '7', '8', '9'].includes(firstDigit)) return false;\n\n // Ambos os tipos usam soma ponderada mod-11 = 0\n let sum = 0;\n for (let i = 0; i < 15; i++) {\n sum += Number(digits[i]) * (15 - i);\n }\n return sum % 11 === 0;\n}\n\n/**\n * Formata um CPF como XXX.XXX.XXX-XX.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns CPF formatado ou a string original se inválido\n */\nexport function formatCPF(cpf: string): string {\n const digits = digitsOnly(cpf);\n if (digits.length !== 11) return cpf;\n return `${digits.slice(0, 3)}.${digits.slice(3, 6)}.${digits.slice(6, 9)}-${digits.slice(9)}`;\n}\n\n/**\n * Formata um CNS como XXX XXXX XXXX XXXX.\n *\n * @param cns — CNS com 15 dígitos\n * @returns CNS formatado ou a string original se inválido\n */\nexport function formatCNS(cns: string): string {\n const digits = digitsOnly(cns);\n if (digits.length !== 15) return cns;\n return `${digits.slice(0, 3)} ${digits.slice(3, 7)} ${digits.slice(7, 11)} ${digits.slice(11)}`;\n}\n\n/**\n * Converte um CPF para um FHIR Identifier.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns FHIR Identifier com sistema RNDS para CPF\n * @throws Error se o CPF for inválido\n */\nexport function cpfToFHIRIdentifier(cpf: string): FHIRIdentifier {\n if (!validateCPF(cpf)) {\n throw new Error('CPF inválido');\n }\n return {\n system: CPF_SYSTEM,\n use: 'official',\n value: digitsOnly(cpf),\n };\n}\n\n/**\n * Converte um CNS para um FHIR Identifier.\n *\n * @param cns — CNS com 15 dígitos\n * @returns FHIR Identifier com sistema RNDS para CNS\n * @throws Error se o CNS for inválido\n */\nexport function cnsToFHIRIdentifier(cns: string): FHIRIdentifier {\n if (!validateCNS(cns)) {\n throw new Error('CNS inválido');\n }\n return {\n system: CNS_SYSTEM,\n use: 'official',\n value: digitsOnly(cns),\n };\n}\n","/**\n * URLs das extensões do IG do fhir-brasil.\n *\n * Quem emite a extensão e quem a lê precisam concordar literalmente na URL: um\n * consumidor procura a extensão pelo `url`, e uma grafia divergente faz o dado\n * sumir sem erro. O teste confere cada uma contra o `Id:` do FSH em\n * `ig/input/fsh/extensions/`, então extensão nova no IG sem constante aqui, ou\n * o inverso, reprova.\n */\n\n/** Canonical do IG, como está no `sushi-config.yaml`. */\nexport const IG_CANONICAL = 'https://fhir-brasil.dev.br/ig';\n\nconst structureDefinition = (id: string): string => `${IG_CANONICAL}/StructureDefinition/${id}`;\n\n/**\n * Extensões do IG, pela URL.\n *\n * As que têm partes (`extractionSource`, `extractionConfidence`, `asPrinted`)\n * levam as partes em `extension[]` aninhado, cada uma com `url` relativo: o\n * nome da parte, como `page` ou `reading`. Ver o FSH de cada uma.\n */\nexport const FHIR_BRASIL_EXTENSIONS = {\n /** `Observation`: valor e faixa como impressos, quando a Observation traz outros. */\n asPrinted: structureDefinition('as-printed'),\n /** `Observation`: extraída de PDF via OCR. */\n derivedFromOCR: structureDefinition('derived-from-ocr'),\n /** `Observation`: confiança na leitura e na interpretação, de 0 a 1. */\n extractionConfidence: structureDefinition('extraction-confidence'),\n /** `Observation`: páginas, trecho citado e caixa do trecho no documento. */\n extractionSource: structureDefinition('extraction-source'),\n /** `DiagnosticReport`: lido da tabela de histórico de outro laudo. */\n reprintedIn: structureDefinition('reprinted-in'),\n /** `Observation`: lido do documento, mas substituído por outro valor do mesmo laudo. */\n superseded: structureDefinition('superseded'),\n /** `Observation`: unidade impressa ao lado de um resultado em texto. */\n textValueUnit: structureDefinition('text-value-unit'),\n} as const;\n","/**\n * Código do tipo de amostra a partir do material impresso no laudo.\n *\n * O perfil `BRAmostraBiologica-1.0` da RNDS vincula `Specimen.type` ao ValueSet\n * `BRTipoAmostra-1.0` com força `required`, exige `type.coding` (1..1) e proíbe\n * `type.text` (0..0). Um `Specimen` só com o texto do laudo não passa, e é o que\n * a extração produzia.\n *\n * O ValueSet tem 63 códigos, e quase todos são de vigilância respiratória vindos\n * do GAL: swab nasofaríngeo, lavado brônquico, fragmento de órgão. Para laudo de\n * rotina sobram seis, e esses seis cobrem o que um painel de sangue e urina\n * imprime.\n *\n * Não há código para fezes no ValueSet. Isso não afeta a extração, cujo catálogo\n * não tem nenhum biomarcador de origem fecal: um parasitológico não vira\n * `Observation`, então não chega a pedir `Specimen`.\n *\n * @see https://rnds-fhir.saude.gov.br/StructureDefinition-BRAmostraBiologica-1.0.html\n * @see https://rnds-fhir.saude.gov.br/ValueSet-BRTipoAmostra-1.0.html\n */\nimport type { FHIRCoding } from './fhir-types';\n\n/** ValueSet ao qual `Specimen.type` está vinculado no `BRAmostraBiologica`. */\nexport const BR_TIPO_AMOSTRA_VALUESET = 'https://rnds-fhir.saude.gov.br/ValueSet/BRTipoAmostra-1.0';\n\n/**\n * CodeSystem dos códigos que este módulo emite.\n *\n * O ValueSet também inclui o `BRTipoAmostraGAL`, que traz \"Sangue\" e \"Sangue com\n * EDTA\" soltos. Ficaram de fora porque a URL canônica daquele CodeSystem não foi\n * confirmada na fonte, e código de terminologia não se deduz de slug. Material\n * assim cai no caminho de não mapeado até alguém abrir o IG e confirmar.\n */\nexport const HL7_SPECIMEN_TYPE_SYSTEM = 'http://terminology.hl7.org/CodeSystem/v2-0487';\n\n/**\n * Os `display` são cópia literal do ValueSet, com a caixa dele.\n *\n * A chave é o texto já normalizado, e por enquanto é só o próprio display. Não\n * há sinônimo inventado aqui: a extração copia o material verbatim do laudo, e a\n * lista de variações que os laboratórios de fato imprimem ainda não foi medida\n * (a captura de material entrou em produção em 05/09/2026). Variação real\n * observada entra depois, com o laudo que a produziu.\n */\nconst CODINGS: ReadonlyArray<{ code: string; display: string }> = [\n { code: 'SER', display: 'Soro' },\n { code: 'PLAS', display: 'Plasma' },\n { code: 'WB', display: 'Sangue Total' },\n { code: 'UR', display: 'Urina' },\n { code: 'CSF', display: 'Líquor' },\n { code: 'SAL', display: 'Saliva' },\n];\n\n/**\n * Caixa, acento e espaço sobrando não distinguem material.\n *\n * Só isso. Não separa `camelCase` nem troca barra por espaço, ao contrário do\n * normalizador de nomes de biomarcador: \"Soro/Plasma\" impresso numa linha só é\n * ambíguo de verdade, e escolher um dos dois seria inferência. Sem casar, ele\n * segue o caminho do não mapeado.\n *\n * Os caracteres invisíveis saem antes, e a divisão entre as duas regras é a do\n * próprio Unicode: `\\p{Cf}` são os de formatação, que não ocupam espaço e por\n * isso são apagados, e `\\s` são os de espaço, que são colapsados. A camada de\n * texto de PDF emite os dois tipos, e um U+200B no meio de \"Soro\" derruba o\n * casamento sem deixar rastro na tela.\n *\n * Vale a categoria em vez da lista porque a lista nunca fecha. Enumerando, o\n * hífen opcional (U+00AD) tinha ficado de fora, e ele aparece justamente onde\n * um nome composto como \"Sangue Total\" quebra de linha.\n */\nconst INVISIBLE = /\\p{Cf}/gu;\n\nconst normalize = (text: string): string =>\n text\n .replace(INVISIBLE, '')\n .normalize('NFD')\n .replace(/[\\u0300-\\u036f]/g, '')\n .toLowerCase()\n .replace(/\\s+/g, ' ')\n .trim();\n\nconst BY_NORMALIZED_TEXT = new Map(\n CODINGS.map(({ code, display }) => [\n normalize(display),\n { code, display, system: HL7_SPECIMEN_TYPE_SYSTEM } satisfies FHIRCoding,\n ]),\n);\n\n/**\n * Coding do ValueSet para o material impresso, ou `undefined` sem casar.\n *\n * `undefined` é resposta legítima e não erro: o laudo pode trazer um material\n * fora do ValueSet, ou uma grafia que ninguém viu ainda. Quem chama decide o que\n * fazer, e a decisão que não existe é preencher com um código aproximado.\n */\nexport const specimenTypeCoding = (text: string): FHIRCoding | undefined =>\n 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1
+ {"version":3,"sources":["../src/category-groups.ts","../src/intervention-converter.ts","../src/dexa-zone-data.ts","../src/screening-intervals.ts","../src/i18n.ts","../src/identifiers.ts","../src/extension-urls.ts","../src/specimen-types.ts"],"sourcesContent":["/**\n * Agrupamento de categorias clínicas em 10 grupos de alto nível.\n *\n * `BiomarkerDefinition.category` armazena 20 sub-categorias (granularidade\n * fina, ex: `tireoide`, `pancreas`). Este módulo agrupa essas\n * sub-categorias em 10 buckets clínicos amplos para apresentação no\n * site, na API pública e em material de divulgação.\n *\n * As sub-categorias permanecem como fonte da verdade nos dados; este\n * agrupamento é uma camada derivada.\n */\n\nexport type CategoryGroup =\n | 'cardiovascular'\n | 'metabolico-endocrino'\n | 'renal-eletrolitico'\n | 'hepatico-biliar'\n | 'hematologico'\n | 'imunologico'\n | 'oncologico'\n | 'nutricional-ambiental'\n | 'saude-reprodutiva'\n | 'composicao-envelhecimento';\n\nexport interface CategoryGroupInfo {\n /** Rótulo em inglês */\n en: string;\n /** Rótulo em português */\n pt: string;\n /** Slug (kebab-case, sem acento) */\n slug: CategoryGroup;\n /** Sub-categorias da fonte agrupadas neste bucket */\n subcategories: readonly string[];\n}\n\nexport const CATEGORY_GROUPS: Record<CategoryGroup, CategoryGroupInfo> = {\n cardiovascular: {\n en: 'Cardiovascular',\n pt: 'Cardiovascular',\n slug: 'cardiovascular',\n subcategories: ['coracao'],\n },\n 'composicao-envelhecimento': {\n en: 'Body Composition & Aging',\n pt: 'Composição Corporal e Envelhecimento',\n slug: 'composicao-envelhecimento',\n subcategories: ['composicao-corporal', 'densidade-ossea', 'estresse-envelhecimento'],\n },\n hematologico: {\n en: 'Hematology',\n pt: 'Hematológico',\n slug: 'hematologico',\n subcategories: ['sangue'],\n },\n 'hepatico-biliar': {\n en: 'Hepatic & Biliary',\n pt: 'Hepático e Biliar',\n slug: 'hepatico-biliar',\n subcategories: ['figado'],\n },\n imunologico: {\n en: 'Immunology',\n pt: 'Imunológico',\n slug: 'imunologico',\n subcategories: ['autoimunidade', 'regulacao-imunologica'],\n },\n 'metabolico-endocrino': {\n en: 'Metabolic & Endocrine',\n pt: 'Metabólico e Endócrino',\n slug: 'metabolico-endocrino',\n subcategories: ['metabolico', 'pancreas', 'hormonios', 'tireoide'],\n },\n 'nutricional-ambiental': {\n en: 'Nutrition & Environmental Exposure',\n pt: 'Nutricional e Exposição Ambiental',\n slug: 'nutricional-ambiental',\n subcategories: ['nutrientes', 'toxinas-ambientais'],\n },\n oncologico: {\n en: 'Oncology',\n pt: 'Oncológico',\n slug: 'oncologico',\n subcategories: ['marcadores-tumorais'],\n },\n 'renal-eletrolitico': {\n en: 'Renal & Electrolytes',\n pt: 'Renal e Eletrolítico',\n slug: 'renal-eletrolitico',\n subcategories: ['rins', 'urina', 'eletrolitos'],\n },\n 'saude-reprodutiva': {\n en: 'Reproductive Health',\n pt: 'Saúde Reprodutiva',\n slug: 'saude-reprodutiva',\n subcategories: ['saude-feminina', 'saude-masculina'],\n },\n};\n\nconst SUBCATEGORY_TO_GROUP = new Map<string, CategoryGroup>();\nfor (const group of Object.values(CATEGORY_GROUPS)) {\n for (const sub of group.subcategories) {\n SUBCATEGORY_TO_GROUP.set(sub, group.slug);\n }\n}\n\n/**\n * Resolve a sub-categoria (granular) para o grupo de alto nível (10 buckets).\n */\nexport function getCategoryGroup(subcategory: string): CategoryGroup | undefined {\n return SUBCATEGORY_TO_GROUP.get(subcategory);\n}\n\n/**\n * Lista todas as sub-categorias mapeadas em algum grupo.\n */\nexport function listMappedSubcategories(): readonly string[] {\n return [...SUBCATEGORY_TO_GROUP.keys()];\n}\n","/**\n * FHIR Intervention Converter\n *\n * Converts interventions (medication, supplement, diet, exercise, sleep)\n * to FHIR R4 MedicationStatement and Observation resources.\n */\n\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { userProfileToFHIR } from './converter';\nimport type { FHIRBundle, FHIRMedicationStatement, FHIRObservation } from './fhir-types';\nimport type { InterventionData, UserProfileData } from './types';\n\n/**\n * Determine MedicationStatement/Observation status based on end date\n */\nfunction interventionStatus(endDate?: string): 'active' | 'completed' {\n if (!endDate) return 'active';\n return new Date(endDate) < new Date() ? 'completed' : 'active';\n}\n\n/**\n * LOINC-like codes for lifestyle observation types\n */\nconst LIFESTYLE_CODES: Record<string, { code: string; display: string }> = {\n diet: { code: '81259-4', display: 'Diet' },\n exercise: { code: '73985-4', display: 'Exercise activity' },\n sleep: { code: '93832-4', display: 'Sleep duration' },\n};\n\n/**\n * Convert medication/supplement intervention to FHIR MedicationStatement\n */\nexport function interventionToFHIRMedicationStatement(\n intervention: InterventionData,\n patientId: string,\n): Addressable<FHIRMedicationStatement> {\n const statement: Addressable<FHIRMedicationStatement> = {\n category: {\n coding: [\n {\n code: 'patientspecified',\n display: 'Patient Specified',\n system: 'http://terminology.hl7.org/CodeSystem/medication-statement-category',\n },\n ],\n },\n dateAsserted: intervention.startDate,\n effectivePeriod: {\n end: intervention.endDate,\n start: intervention.startDate,\n },\n id: `intervention-${intervention.interventionId}`,\n medicationCodeableConcept: {\n text: intervention.name,\n },\n resourceType: 'MedicationStatement',\n status: interventionStatus(intervention.endDate),\n subject: {\n reference: `Patient/${patientId}`,\n },\n };\n\n if (intervention.notes) {\n statement.note = [{ text: intervention.notes }];\n }\n\n return statement;\n}\n\n/**\n * Convert diet/exercise/sleep intervention to FHIR Observation (social-history)\n */\nexport function interventionToFHIRObservation(\n intervention: InterventionData,\n patientId: string,\n): Addressable<FHIRObservation> {\n const lifestyleCode = LIFESTYLE_CODES[intervention.type];\n\n const observation: Addressable<FHIRObservation> = {\n category: [\n {\n coding: [\n {\n code: 'social-history',\n display: 'Social History',\n system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n },\n ],\n },\n ],\n code: {\n coding: lifestyleCode\n ? [\n {\n code: lifestyleCode.code,\n display: lifestyleCode.display,\n system: 'http://loinc.org',\n },\n ]\n : [],\n text: intervention.name,\n },\n effectivePeriod: {\n end: intervention.endDate,\n start: intervention.startDate,\n },\n id: `intervention-${intervention.interventionId}`,\n resourceType: 'Observation',\n status: 'final',\n subject: {\n reference: `Patient/${patientId}`,\n },\n valueString: intervention.name,\n };\n\n if (intervention.notes) {\n observation.note = [{ text: intervention.notes }];\n }\n\n return observation;\n}\n\n/**\n * Convert all interventions to a FHIR Bundle\n */\nexport function interventionsToFHIRBundle(\n interventions: InterventionData[],\n userProfile: UserProfileData,\n): FHIRBundle {\n const patientId = userProfile.userId;\n const fhirPatient = userProfileToFHIR(userProfile);\n\n const entries = interventions.map((intervention) => {\n const isMedication = intervention.type === 'medication' || intervention.type === 'supplement';\n const resource = isMedication\n ? interventionToFHIRMedicationStatement(intervention, patientId)\n : interventionToFHIRObservation(intervention, patientId);\n\n return { fullUrl: entryFullUrl(resource), resource };\n });\n\n return {\n entry: [{ fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient }, ...entries],\n resourceType: 'Bundle',\n type: 'collection',\n };\n}\n","/**\n * Structured zone data for DEXA body composition and bone density charts.\n *\n * Body fat zones derived from Gallagher et al. Am J Clin Nutr 2000;72:694-701 (PMID: 10966886)\n * and ACSM Guidelines for Exercise Testing, 11th Ed (2021).\n *\n * T-Score zones from WHO criteria (Kanis JA, Osteoporos Int, PMID: 7696835).\n */\n\nexport interface BodyFatZone {\n ageMax: number;\n ageMin: number;\n color: string;\n fatPctMax: number;\n fatPctMin: number;\n label: string;\n sex: 'F' | 'M';\n}\n\ninterface AgeBracket {\n ageMax: number;\n ageMin: number;\n label: string;\n}\n\nconst AGE_BRACKETS: AgeBracket[] = [\n { ageMax: 25, ageMin: 18, label: '18-25' },\n { ageMax: 35, ageMin: 26, label: '26-35' },\n { ageMax: 45, ageMin: 36, label: '36-45' },\n { ageMax: 55, ageMin: 46, label: '46-55' },\n { ageMax: 99, ageMin: 56, label: '56+' },\n];\n\n// Zone boundaries per age bracket for men: [essential, athletic, fitness, average, obese]\n// Each value is the upper bound of the zone\nconst MALE_ZONES: number[][] = [\n [5, 10, 20, 25, 40],\n [5, 11, 21, 26, 40],\n [5, 12, 22, 27, 40],\n [5, 13, 23, 28, 40],\n [5, 14, 24, 29, 40],\n];\n\nconst FEMALE_ZONES: number[][] = [\n [13, 18, 28, 32, 45],\n [13, 18, 29, 33, 45],\n [13, 19, 30, 34, 45],\n [13, 20, 31, 35, 45],\n [13, 20, 32, 36, 45],\n];\n\ninterface ZoneDefinition {\n color: string;\n label: string;\n}\n\nconst ZONE_DEFS: ZoneDefinition[] = [\n { color: '#3b82f6', label: 'Essencial' },\n { color: '#06b6d4', label: 'Atlético' },\n { color: '#22c55e', label: 'Fitness' },\n { color: '#eab308', label: 'Média' },\n { color: '#ef4444', label: 'Obeso' },\n];\n\nfunction buildZones(sex: 'F' | 'M', zoneData: number[][]): BodyFatZone[] {\n const zones: BodyFatZone[] = [];\n for (let i = 0; i < AGE_BRACKETS.length; i++) {\n const bracket = AGE_BRACKETS[i]!;\n const b = zoneData[i]!;\n zones.push({\n ...bracket,\n color: ZONE_DEFS[0]!.color,\n fatPctMax: b[0]!,\n fatPctMin: 0,\n label: ZONE_DEFS[0]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[1]!.color,\n fatPctMax: b[1]!,\n fatPctMin: b[0]!,\n label: ZONE_DEFS[1]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[2]!.color,\n fatPctMax: b[2]!,\n fatPctMin: b[1]!,\n label: ZONE_DEFS[2]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[3]!.color,\n fatPctMax: b[3]!,\n fatPctMin: b[2]!,\n label: ZONE_DEFS[3]!.label,\n sex,\n });\n zones.push({\n ...bracket,\n color: ZONE_DEFS[4]!.color,\n fatPctMax: b[4]!,\n fatPctMin: b[3]!,\n label: ZONE_DEFS[4]!.label,\n sex,\n });\n }\n return zones;\n}\n\nexport const BODY_FAT_ZONES: BodyFatZone[] = [\n ...buildZones('M', MALE_ZONES),\n ...buildZones('F', FEMALE_ZONES),\n];\n\nexport { AGE_BRACKETS, ZONE_DEFS };\n\nexport interface TScoreZone {\n color: string;\n label: string;\n max: number;\n min: number;\n}\n\nexport const T_SCORE_ZONES: TScoreZone[] = [\n { color: '#22c55e', label: 'Normal', max: 4, min: -1.0 },\n { color: '#eab308', label: 'Osteopenia', max: -1.0, min: -2.5 },\n { color: '#ef4444', label: 'Osteoporose', max: -2.5, min: -5 },\n];\n","/**\n * Screening Intervals Configuration\n *\n * Defines recommended screening intervals for different biomarker categories\n * based on clinical guidelines and best practices.\n */\n\n/**\n * Screening interval in months\n */\nexport type ScreeningIntervalMonths = 3 | 6 | 12;\n\n/**\n * Biomarker category with its recommended screening interval\n */\nexport interface CategoryScreeningInterval {\n category: string;\n intervalMonths: ScreeningIntervalMonths;\n nameEn: string;\n namePt: string;\n}\n\n/**\n * Screening interval configuration for each category\n *\n * Categories are grouped by their recommended screening intervals:\n * - 3 months: Body composition and bone density (frequently changing metrics)\n * - 6 months: Metabolic panel and nutrients (moderate change rate)\n * - 12 months: Standard blood panels (stable long-term markers)\n */\nexport const CATEGORY_SCREENING_INTERVALS: CategoryScreeningInterval[] = [\n // 3-month intervals - Body composition (frequently changing)\n {\n category: 'composicao-corporal',\n intervalMonths: 3,\n nameEn: 'Body Composition',\n namePt: 'Composição Corporal',\n },\n {\n category: 'densidade-ossea',\n intervalMonths: 3,\n nameEn: 'Bone Density',\n namePt: 'Densidade Óssea',\n },\n\n // 6-month intervals - Metabolic and nutrients\n {\n category: 'metabolico',\n intervalMonths: 6,\n nameEn: 'Metabolic Panel',\n namePt: 'Painel Metabólico',\n },\n {\n category: 'nutrientes',\n intervalMonths: 6,\n nameEn: 'Nutrients',\n namePt: 'Nutrientes',\n },\n {\n category: 'pancreas',\n intervalMonths: 6,\n nameEn: 'Pancreas',\n namePt: 'Pâncreas',\n },\n\n // 12-month intervals - Standard blood panels\n {\n category: 'coracao',\n intervalMonths: 12,\n nameEn: 'Heart Health',\n namePt: 'Saúde Cardiovascular',\n },\n {\n category: 'tireoide',\n intervalMonths: 12,\n nameEn: 'Thyroid',\n namePt: 'Tireoide',\n },\n {\n category: 'sangue',\n intervalMonths: 12,\n nameEn: 'Blood Count',\n namePt: 'Hemograma',\n },\n {\n category: 'figado',\n intervalMonths: 12,\n nameEn: 'Liver Function',\n namePt: 'Função Hepática',\n },\n {\n category: 'rins',\n intervalMonths: 12,\n nameEn: 'Kidney Function',\n namePt: 'Função Renal',\n },\n {\n category: 'saude-feminina',\n intervalMonths: 12,\n nameEn: \"Women's Health\",\n namePt: 'Saúde Feminina',\n },\n {\n category: 'saude-masculina',\n intervalMonths: 12,\n nameEn: \"Men's Health\",\n namePt: 'Saúde Masculina',\n },\n {\n category: 'eletrolitos',\n intervalMonths: 12,\n nameEn: 'Electrolytes',\n namePt: 'Eletrólitos',\n },\n {\n category: 'estresse-envelhecimento',\n intervalMonths: 12,\n nameEn: 'Stress & Aging',\n namePt: 'Estresse e Envelhecimento',\n },\n {\n category: 'autoimunidade',\n intervalMonths: 12,\n nameEn: 'Autoimmunity',\n namePt: 'Autoimunidade',\n },\n {\n category: 'regulacao-imunologica',\n intervalMonths: 12,\n nameEn: 'Immune Regulation',\n namePt: 'Regulação Imunológica',\n },\n {\n category: 'toxinas-ambientais',\n intervalMonths: 12,\n nameEn: 'Environmental Toxins',\n namePt: 'Toxinas Ambientais',\n },\n {\n category: 'urina',\n intervalMonths: 12,\n nameEn: 'Urinalysis',\n namePt: 'Urina',\n },\n];\n\n/**\n * Get screening interval for a category\n */\nexport const getScreeningInterval = (category: string): CategoryScreeningInterval | undefined => {\n return CATEGORY_SCREENING_INTERVALS.find((c) => c.category === category);\n};\n\n/**\n * Get all categories with a specific interval\n */\nexport const getCategoriesByInterval = (\n intervalMonths: ScreeningIntervalMonths,\n): CategoryScreeningInterval[] => {\n return CATEGORY_SCREENING_INTERVALS.filter((c) => c.intervalMonths === intervalMonths);\n};\n\n/**\n * Calculate next screening date based on last test date and category\n */\nexport const calculateNextScreeningDate = (lastTestDate: Date, category: string): Date | null => {\n const interval = getScreeningInterval(category);\n if (!interval) return null;\n\n const nextDate = new Date(lastTestDate);\n nextDate.setMonth(nextDate.getMonth() + interval.intervalMonths);\n return nextDate;\n};\n\n/**\n * Check if a category is due for screening\n */\nexport const isScreeningDue = (\n lastTestDate: Date,\n category: string,\n referenceDate: Date = new Date(),\n): boolean => {\n const nextDate = calculateNextScreeningDate(lastTestDate, category);\n if (!nextDate) return false;\n return referenceDate >= nextDate;\n};\n\n/**\n * Get categories that are due for screening based on last test dates\n */\nexport const getDueCategories = (\n lastTestDates: Record<string, Date>,\n referenceDate: Date = new Date(),\n): CategoryScreeningInterval[] => {\n return CATEGORY_SCREENING_INTERVALS.filter((interval) => {\n const lastDate = lastTestDates[interval.category];\n if (!lastDate) return true; // Never tested = due\n return isScreeningDue(lastDate, interval.category, referenceDate);\n });\n};\n\n/**\n * Get days until next screening for a category\n */\nexport const getDaysUntilScreening = (\n lastTestDate: Date,\n category: string,\n referenceDate: Date = new Date(),\n): number | null => {\n const nextDate = calculateNextScreeningDate(lastTestDate, category);\n if (!nextDate) return null;\n\n const diffTime = nextDate.getTime() - referenceDate.getTime();\n return Math.ceil(diffTime / (1000 * 60 * 60 * 24));\n};\n","/**\n * Portuguese pluralization utility using native Intl.PluralRules\n * Provides automatic pluralization for common words used in the app\n */\n\nconst pluralRules = new Intl.PluralRules('pt-BR');\n\n/**\n * Dictionary of Portuguese words with their plural forms\n * Key is the singular form, value is the plural form\n */\nconst dictionary: Record<string, string> = {\n // Common nouns\n arquivo: 'arquivos',\n biomarcador: 'biomarcadores',\n // Past participles (masculine)\n cadastrado: 'cadastrados',\n // Past participles (feminine)\n concluída: 'concluídas',\n confirmado: 'confirmados',\n convertido: 'convertidos',\n convidado: 'convidados',\n convite: 'convites',\n disponível: 'disponíveis',\n documento: 'documentos',\n enviado: 'enviados',\n exame: 'exames',\n excluída: 'excluídas',\n\n excluído: 'excluídos',\n // Verbs (3rd person)\n falhou: 'falharam',\n falta: 'faltam',\n ignorado: 'ignorados',\n item: 'itens',\n outro: 'outros',\n página: 'páginas',\n pendente: 'pendentes',\n registro: 'registros',\n removido: 'removidos',\n\n resultado: 'resultados',\n revisão: 'revisões',\n\n revogado: 'revogados',\n usuário: 'usuários',\n};\n\n/**\n * Get the plural form of a word from the dictionary\n * Falls back to adding 's' if word is not in dictionary\n */\nconst getPluralForm = (singular: string): string => {\n return dictionary[singular] ?? `${singular}s`;\n};\n\n/**\n * Returns the correct singular or plural form based on count\n * Uses Intl.PluralRules for proper locale-aware pluralization\n *\n * @example\n * plural(1, 'usuário') // 'usuário'\n * plural(3, 'usuário') // 'usuários'\n * plural(0, 'registro') // 'registros'\n */\nexport const plural = (count: number, word: string): string => {\n const rule = pluralRules.select(count);\n return rule === 'one' ? word : getPluralForm(word);\n};\n\n/**\n * Returns count with the correct singular or plural form\n *\n * @example\n * pluralCount(1, 'usuário') // '1 usuário'\n * pluralCount(3, 'usuário') // '3 usuários'\n */\nexport const pluralCount = (count: number, word: string): string => {\n return `${count} ${plural(count, word)}`;\n};\n\n/**\n * Returns the correct form for compound phrases (noun + adjective)\n * Both words are pluralized together\n *\n * @example\n * pluralPhrase(1, 'usuário', 'cadastrado') // 'usuário cadastrado'\n * pluralPhrase(3, 'usuário', 'cadastrado') // 'usuários cadastrados'\n * pluralPhrase(2, 'revisão', 'excluída') // 'revisões excluídas'\n */\nexport const pluralPhrase = (count: number, noun: string, adjective: string): string => {\n const rule = pluralRules.select(count);\n if (rule === 'one') {\n return `${noun} ${adjective}`;\n }\n return `${getPluralForm(noun)} ${getPluralForm(adjective)}`;\n};\n\n/**\n * Returns count with the correct compound phrase form\n *\n * @example\n * pluralPhraseCount(1, 'usuário', 'cadastrado') // '1 usuário cadastrado'\n * pluralPhraseCount(3, 'convite', 'enviado') // '3 convites enviados'\n */\nexport const pluralPhraseCount = (count: number, noun: string, adjective: string): string => {\n return `${count} ${pluralPhrase(count, noun, adjective)}`;\n};\n","/**\n * Helpers para identificadores brasileiros — CPF e CNS\n *\n * Validação, formatação e conversão para FHIR Identifier.\n * Algoritmos de validação baseados nas especificações oficiais:\n * - CPF: Receita Federal (mod-11, dois dígitos verificadores)\n * - CNS: Ministério da Saúde (mod-11 para definitivos, soma ponderada para provisórios)\n */\n\nimport type { FHIRIdentifier } from './fhir-types';\n\nconst CPF_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cpf';\nconst CNS_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cns';\n\n/**\n * Remove caracteres não-numéricos de uma string.\n */\nfunction digitsOnly(value: string): string {\n return value.replace(/\\D/g, '');\n}\n\n/**\n * Valida um CPF brasileiro usando algoritmo mod-11.\n *\n * @param cpf — CPF com ou sem formatação (ex: \"123.456.789-09\" ou \"12345678909\")\n * @returns true se o CPF é estruturalmente válido\n */\nexport function validateCPF(cpf: string): boolean {\n const digits = digitsOnly(cpf);\n\n if (digits.length !== 11) return false;\n\n // Rejeitar sequências de dígitos iguais (ex: 111.111.111-11)\n if (/^(\\d)\\1{10}$/.test(digits)) return false;\n\n // Primeiro dígito verificador\n let sum = 0;\n for (let i = 0; i < 9; i++) {\n sum += Number(digits[i]) * (10 - i);\n }\n let remainder = (sum * 10) % 11;\n if (remainder === 10) remainder = 0;\n if (remainder !== Number(digits[9])) return false;\n\n // Segundo dígito verificador\n sum = 0;\n for (let i = 0; i < 10; i++) {\n sum += Number(digits[i]) * (11 - i);\n }\n remainder = (sum * 10) % 11;\n if (remainder === 10) remainder = 0;\n if (remainder !== Number(digits[10])) return false;\n\n return true;\n}\n\n/**\n * Valida um CNS (Cartão Nacional de Saúde) brasileiro.\n *\n * CNS definitivos começam com 1 ou 2 (mod-11).\n * CNS provisórios começam com 7, 8 ou 9 (soma ponderada mod-11 = 0).\n *\n * @param cns — CNS com 15 dígitos\n * @returns true se o CNS é estruturalmente válido\n */\nexport function validateCNS(cns: string): boolean {\n const digits = digitsOnly(cns);\n\n if (digits.length !== 15) return false;\n\n const firstDigit = digits[0]!;\n\n // CNS deve começar com 1, 2 (definitivo) ou 7, 8, 9 (provisório)\n if (!['1', '2', '7', '8', '9'].includes(firstDigit)) return false;\n\n // Ambos os tipos usam soma ponderada mod-11 = 0\n let sum = 0;\n for (let i = 0; i < 15; i++) {\n sum += Number(digits[i]) * (15 - i);\n }\n return sum % 11 === 0;\n}\n\n/**\n * Formata um CPF como XXX.XXX.XXX-XX.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns CPF formatado ou a string original se inválido\n */\nexport function formatCPF(cpf: string): string {\n const digits = digitsOnly(cpf);\n if (digits.length !== 11) return cpf;\n return `${digits.slice(0, 3)}.${digits.slice(3, 6)}.${digits.slice(6, 9)}-${digits.slice(9)}`;\n}\n\n/**\n * Formata um CNS como XXX XXXX XXXX XXXX.\n *\n * @param cns — CNS com 15 dígitos\n * @returns CNS formatado ou a string original se inválido\n */\nexport function formatCNS(cns: string): string {\n const digits = digitsOnly(cns);\n if (digits.length !== 15) return cns;\n return `${digits.slice(0, 3)} ${digits.slice(3, 7)} ${digits.slice(7, 11)} ${digits.slice(11)}`;\n}\n\n/**\n * Converte um CPF para um FHIR Identifier.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns FHIR Identifier com sistema RNDS para CPF\n * @throws Error se o CPF for inválido\n */\nexport function cpfToFHIRIdentifier(cpf: string): FHIRIdentifier {\n if (!validateCPF(cpf)) {\n throw new Error('CPF inválido');\n }\n return {\n system: CPF_SYSTEM,\n use: 'official',\n value: digitsOnly(cpf),\n };\n}\n\n/**\n * Converte um CNS para um FHIR Identifier.\n *\n * @param cns — CNS com 15 dígitos\n * @returns FHIR Identifier com sistema RNDS para CNS\n * @throws Error se o CNS for inválido\n */\nexport function cnsToFHIRIdentifier(cns: string): FHIRIdentifier {\n if (!validateCNS(cns)) {\n throw new Error('CNS inválido');\n }\n return {\n system: CNS_SYSTEM,\n use: 'official',\n value: digitsOnly(cns),\n };\n}\n","/**\n * URLs das extensões do IG do fhir-brasil.\n *\n * Quem emite a extensão e quem a lê precisam concordar literalmente na URL: um\n * consumidor procura a extensão pelo `url`, e uma grafia divergente faz o dado\n * sumir sem erro. O teste confere cada uma contra o `Id:` do FSH em\n * `ig/input/fsh/extensions/`, então extensão nova no IG sem constante aqui, ou\n * o inverso, reprova.\n */\n\n/** Canonical do IG, como está no `sushi-config.yaml`. */\nexport const IG_CANONICAL = 'https://fhir-brasil.dev.br/ig';\n\nconst structureDefinition = (id: string): string => `${IG_CANONICAL}/StructureDefinition/${id}`;\n\n/**\n * Extensões do IG, pela URL.\n *\n * As que têm partes (`extractionSource`, `extractionConfidence`, `asPrinted`)\n * levam as partes em `extension[]` aninhado, cada uma com `url` relativo: o\n * nome da parte, como `page` ou `reading`. Ver o FSH de cada uma.\n */\nexport const FHIR_BRASIL_EXTENSIONS = {\n /** `Observation`: valor e faixa como impressos, quando a Observation traz outros. */\n asPrinted: structureDefinition('as-printed'),\n /** `Observation`: extraída de PDF via OCR. */\n derivedFromOCR: structureDefinition('derived-from-ocr'),\n /** `Observation`: confiança na leitura e na interpretação, de 0 a 1. */\n extractionConfidence: structureDefinition('extraction-confidence'),\n /** `Observation`: páginas, trecho citado e caixa do trecho no documento. */\n extractionSource: structureDefinition('extraction-source'),\n /** `DiagnosticReport`: lido da tabela de histórico de outro laudo. */\n reprintedIn: structureDefinition('reprinted-in'),\n /** `Observation`: lido do documento, mas substituído por outro valor do mesmo laudo. */\n superseded: structureDefinition('superseded'),\n /** `Observation`: unidade impressa ao lado de um resultado em texto. */\n textValueUnit: structureDefinition('text-value-unit'),\n} as const;\n","/**\n * Código do tipo de amostra a partir do material impresso no laudo.\n *\n * O perfil `BRAmostraBiologica-1.0` da RNDS vincula `Specimen.type` ao ValueSet\n * `BRTipoAmostra-1.0` com força `required`, exige `type.coding` (1..1) e proíbe\n * `type.text` (0..0). Um `Specimen` só com o texto do laudo não passa, e é o que\n * a extração produzia.\n *\n * O ValueSet tem 63 códigos, e quase todos são de vigilância respiratória vindos\n * do GAL: swab nasofaríngeo, lavado brônquico, fragmento de órgão. Para laudo de\n * rotina sobram seis, e esses seis cobrem o que um painel de sangue e urina\n * imprime.\n *\n * Não há código para fezes no ValueSet. Isso não afeta a extração, cujo catálogo\n * não tem nenhum biomarcador de origem fecal: um parasitológico não vira\n * `Observation`, então não chega a pedir `Specimen`.\n *\n * @see https://rnds-fhir.saude.gov.br/StructureDefinition-BRAmostraBiologica-1.0.html\n * @see https://rnds-fhir.saude.gov.br/ValueSet-BRTipoAmostra-1.0.html\n */\nimport type { FHIRCoding } from './fhir-types';\n\n/** ValueSet ao qual `Specimen.type` está vinculado no `BRAmostraBiologica`. */\nexport const BR_TIPO_AMOSTRA_VALUESET = 'https://rnds-fhir.saude.gov.br/ValueSet/BRTipoAmostra-1.0';\n\n/**\n * CodeSystem dos códigos que este módulo emite.\n *\n * O ValueSet também inclui o `BRTipoAmostraGAL`, que traz \"Sangue\" e \"Sangue com\n * EDTA\" soltos. Ficaram de fora porque a URL canônica daquele CodeSystem não foi\n * confirmada na fonte, e código de terminologia não se deduz de slug. Material\n * assim cai no caminho de não mapeado até alguém abrir o IG e confirmar.\n */\nexport const HL7_SPECIMEN_TYPE_SYSTEM = 'http://terminology.hl7.org/CodeSystem/v2-0487';\n\n/**\n * Os `display` são cópia literal do ValueSet, com a caixa dele.\n *\n * A chave é o texto já normalizado, e por enquanto é só o próprio display. Não\n * há sinônimo inventado aqui: a extração copia o material verbatim do laudo, e a\n * lista de variações que os laboratórios de fato imprimem ainda não foi medida\n * (a captura de material entrou em produção em 05/09/2026). Variação real\n * observada entra depois, com o laudo que a produziu.\n */\nconst CODINGS: ReadonlyArray<{ code: string; display: string }> = [\n { code: 'SER', display: 'Soro' },\n { code: 'PLAS', display: 'Plasma' },\n { code: 'WB', display: 'Sangue Total' },\n { code: 'UR', display: 'Urina' },\n { code: 'CSF', display: 'Líquor' },\n { code: 'SAL', display: 'Saliva' },\n];\n\n/**\n * Caixa, acento e espaço sobrando não distinguem material.\n *\n * Só isso. Não separa `camelCase` nem troca barra por espaço, ao contrário do\n * normalizador de nomes de biomarcador: \"Soro/Plasma\" impresso numa linha só é\n * ambíguo de verdade, e escolher um dos dois seria inferência. Sem casar, ele\n * segue o caminho do não mapeado.\n *\n * Os caracteres invisíveis saem antes, e a divisão entre as duas regras é a do\n * próprio Unicode: `\\p{Cf}` são os de formatação, que não ocupam espaço e por\n * isso são apagados, e `\\s` são os de espaço, que são colapsados. A camada de\n * texto de PDF emite os dois tipos, e um U+200B no meio de \"Soro\" derruba o\n * casamento sem deixar rastro na tela.\n *\n * Vale a categoria em vez da lista porque a lista nunca fecha. Enumerando, o\n * hífen opcional (U+00AD) tinha ficado de fora, e ele aparece justamente onde\n * um nome composto como \"Sangue Total\" quebra de linha.\n */\nconst INVISIBLE = /\\p{Cf}/gu;\n\nconst normalize = (text: string): string =>\n text\n .replace(INVISIBLE, '')\n .normalize('NFD')\n .replace(/[\\u0300-\\u036f]/g, '')\n .toLowerCase()\n .replace(/\\s+/g, ' ')\n .trim();\n\nconst BY_NORMALIZED_TEXT = new Map(\n CODINGS.map(({ code, display }) => [\n normalize(display),\n { code, display, system: HL7_SPECIMEN_TYPE_SYSTEM } satisfies FHIRCoding,\n ]),\n);\n\n/**\n * Coding do ValueSet para o material impresso, ou `undefined` sem casar.\n *\n * `undefined` é resposta legítima e não erro: o laudo pode trazer um material\n * fora do ValueSet, ou uma grafia que ninguém viu ainda. Quem chama decide o que\n * fazer, e a decisão que não existe é preencher com um código aproximado.\n */\nexport const specimenTypeCoding = (text: string): FHIRCoding | undefined =>\n 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package/dist/reference-ranges.cjs CHANGED
@@ -5,7 +5,9 @@
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- var _chunkLXKFVJF4cjs = require('./chunk-LXKFVJF4.cjs');
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+ var _chunkVKLWTTUOcjs = require('./chunk-VKLWTTUO.cjs');
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  require('./chunk-5RC7C7HJ.cjs');
10
12
  require('./chunk-T75NZM56.cjs');
11
13
 
@@ -15,5 +17,7 @@ require('./chunk-T75NZM56.cjs');
15
17
 
16
18
 
17
19
 
18
- exports.applyFallbackReferenceRanges = _chunkLXKFVJF4cjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkLXKFVJF4cjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunkLXKFVJF4cjs.defaultReferenceRanges; exports.getFallbackReferenceRange = _chunkLXKFVJF4cjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkLXKFVJF4cjs.getRangeDirection; exports.getReferenceRange = _chunkLXKFVJF4cjs.getReferenceRange;
20
+
21
+
22
+ exports.applyFallbackReferenceRanges = _chunkVKLWTTUOcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkVKLWTTUOcjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunkVKLWTTUOcjs.defaultReferenceRanges; exports.flagAgainstCatalogRange = _chunkVKLWTTUOcjs.flagAgainstCatalogRange; exports.getFallbackReferenceRange = _chunkVKLWTTUOcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkVKLWTTUOcjs.getRangeDirection; exports.getReferenceRange = _chunkVKLWTTUOcjs.getReferenceRange; exports.referenceRangeMeaning = _chunkVKLWTTUOcjs.referenceRangeMeaning;
19
23
  //# sourceMappingURL=reference-ranges.cjs.map
package/dist/reference-ranges.cjs.map CHANGED
@@ -1 +1 @@
1
- {"version":3,"sources":["/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/reference-ranges.cjs"],"names":[],"mappings":"AAAA;AACE;AACA;AACA;AACA;AACA;AACA;AACF,wDAA6B;AAC7B,gCAA6B;AAC7B,gCAA6B;AAC7B;AACE;AACA;AACA;AACA;AACA;AACA;AACF,qcAAC","file":"/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/reference-ranges.cjs"}
1
+ {"version":3,"sources":["/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/reference-ranges.cjs"],"names":[],"mappings":"AAAA;AACE;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACF,wDAA6B;AAC7B,gCAA6B;AAC7B,gCAA6B;AAC7B;AACE;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACF,2lBAAC","file":"/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/reference-ranges.cjs"}
package/dist/reference-ranges.d.cts CHANGED
@@ -22,6 +22,35 @@ type SexKey = 'M' | 'F' | 'all';
22
22
  * - `not-required`: valor independe do estado prandial (ex.: HbA1c, TSH).
23
23
  */
24
24
  type FastingRequirement = 'strict' | 'preferred' | 'not-required';
25
+ /**
26
+ * Que tipo de afirmação a faixa faz. As três respondem perguntas diferentes, e
27
+ * uma banda de "faixa normal" que as misture diz coisas diferentes conforme o
28
+ * marcador.
29
+ *
30
+ * - `reference-interval`: o intervalo de referência do ensaio, tirado de uma
31
+ * população de referência saudável (percentis centrais, ou o percentil 99
32
+ * no caso das troponinas). Estar fora dele é estar fora do esperado para
33
+ * quem não tem a doença.
34
+ * - `decision-threshold`: limiar de decisão de diretriz ou de estudo de risco
35
+ * (meta de LDL, corte de pré-diabetes, estágio de DRC). Diz o que fazer, e
36
+ * não como o valor se distribui em gente saudável.
37
+ * - `population`: como o valor se distribui numa população, sem filtrar por
38
+ * saúde (NHANES, coortes de base populacional). Descreve, não julga.
39
+ *
40
+ * Em FHIR, o primeiro vira `normal` e o segundo `recommended` no
41
+ * `referenceRange.type`; o terceiro não tem código próprio no
42
+ * `referencerange-meaning`. Ver `referenceRangeMeaning`.
43
+ */
44
+ type RangeKind = 'reference-interval' | 'decision-threshold' | 'population';
45
+ /**
46
+ * Se um limite da faixa é corte clínico ou está ali para o desenho.
47
+ *
48
+ * `display` é o limite que existe para a faixa ter dois lados no gauge ou na
49
+ * banda, e que não deve virar flag: o teto de 100 mg/dL do HDL, o piso 2 da
50
+ * HbA1c. Ausente quer dizer `clinical`, que é o caso comum e o comportamento
51
+ * de sempre da comparação crua.
52
+ */
53
+ type BoundKind = 'clinical' | 'display';
25
54
  /**
26
55
  * Reference range configuration for a biomarker
27
56
  */
@@ -31,8 +60,17 @@ interface BiomarkerReferenceRange {
31
60
  * consumidores devem aplicar sinalização adequada quando `strict`.
32
61
  */
33
62
  fastingRequired?: FastingRequirement;
63
+ /**
64
+ * Tipo da faixa. Propagado do `BiomarkerRangeDefinition` (ou da variante que
65
+ * casou) no momento da consulta, como o `source`.
66
+ */
67
+ kind?: RangeKind;
34
68
  max?: number;
69
+ /** Ver `BoundKind`. Ausente vale `clinical`. */
70
+ maxKind?: BoundKind;
35
71
  min?: number;
72
+ /** Ver `BoundKind`. Ausente vale `clinical`. */
73
+ minKind?: BoundKind;
36
74
  optimalMax?: number;
37
75
  optimalMin?: number;
38
76
  /**
@@ -67,6 +105,11 @@ type PregnancyTrimester = 1 | 2 | 3;
67
105
  interface RangeVariant {
68
106
  ageMax?: number;
69
107
  ageMin?: number;
108
+ /**
109
+ * Tipo da faixa desta variante, quando ela vem de outra fonte que a da
110
+ * definição. Ausente herda o `kind` da definição.
111
+ */
112
+ kind?: RangeKind;
70
113
  pregnancyTrimester?: PregnancyTrimester;
71
114
  /**
72
115
  * Quando `true`, a variante só se aplica a contextos de gestação.
@@ -88,7 +131,21 @@ interface RangeVariant {
88
131
  type RangeDirection = 'range' | 'higher-better' | 'lower-better';
89
132
  interface BiomarkerRangeDefinition {
90
133
  default: BiomarkerReferenceRange;
134
+ /**
135
+ * Para que lado o marcador melhora. Serve à cor e ao gauge.
136
+ *
137
+ * Não decide flag: se um limite é corte clínico é o `minKind`/`maxKind` da
138
+ * faixa que diz, e quem compara valor com faixa usa `flagAgainstCatalogRange`.
139
+ * Até a 0.33 o `direction` fazia os dois trabalhos, e eles se separam na
140
+ * composição corporal: o `BodyFatPct` é `lower-better` e o piso dele é
141
+ * clínico.
142
+ */
91
143
  direction?: RangeDirection;
144
+ /**
145
+ * Tipo da faixa. Opcional no tipo para não quebrar quem monta definições
146
+ * próprias; todo o catálogo declara, e um teste garante.
147
+ */
148
+ kind?: RangeKind;
92
149
  /**
93
150
  * Chave de fonte bibliográfica, opcionalmente com localizador.
94
151
  *
@@ -141,6 +198,31 @@ declare function getReferenceRange(testCode: string, context?: ReferenceRangeCon
141
198
  * Returns 'range' (default) if not specified.
142
199
  */
143
200
  declare function getRangeDirection(testCode: string): RangeDirection;
201
+ /**
202
+ * A flag de um valor contra a faixa do catálogo, só pelos limites clínicos.
203
+ *
204
+ * Compara contra a faixa que o `getReferenceRange` devolve para o contexto, e
205
+ * ignora o limite marcado como `display`. Não olha o `direction`: o HDL de 105
206
+ * sai sem flag porque o teto de 100 é `display`, e o `BodyFatPct` de 8% sai
207
+ * `L` porque o piso é clínico, embora o marcador seja `lower-better`.
208
+ *
209
+ * **Só serve para a faixa do catálogo.** Faixa que o laboratório imprimiu é
210
+ * afirmação dele sobre aquela amostra, e a comparação contra ela é crua.
211
+ *
212
+ * Devolve `''` quando o código não tem faixa ou o valor está dentro dela.
213
+ */
214
+ declare function flagAgainstCatalogRange(testCode: string, value: number, context?: ReferenceRangeContext): 'H' | 'L' | '';
215
+ /**
216
+ * O `referenceRange.type` do FHIR para um tipo de faixa.
217
+ *
218
+ * `population` não tem código no `referencerange-meaning`, e a função devolve
219
+ * `undefined` em vez de escolher um parecido.
220
+ */
221
+ declare function referenceRangeMeaning(kind: RangeKind): {
222
+ code: 'normal' | 'recommended';
223
+ display: string;
224
+ system: string;
225
+ } | undefined;
144
226
  /**
145
227
  * Get fallback reference range for a biomarker code (default only, no personalization)
146
228
  * Used by API when LLM doesn't extract reference values
@@ -164,4 +246,4 @@ declare function applyFallbackReferenceRanges<T extends {
164
246
  unit?: string;
165
247
  }>(biomarkers: T[]): number;
166
248
 
167
- export { type BiomarkerRangeDefinition, type BiomarkerReferenceRange, type FastingRequirement, type PregnancyTrimester, type RangeDirection, type RangeVariant, type ReferenceRangeContext, type SexKey, applyFallbackReferenceRanges, biomarkerRangeDefinitions, defaultReferenceRanges, getFallbackReferenceRange, getRangeDirection, getReferenceRange };
249
+ export { type BiomarkerRangeDefinition, type BiomarkerReferenceRange, type BoundKind, type FastingRequirement, type PregnancyTrimester, type RangeDirection, type RangeKind, type RangeVariant, type ReferenceRangeContext, type SexKey, applyFallbackReferenceRanges, biomarkerRangeDefinitions, defaultReferenceRanges, flagAgainstCatalogRange, getFallbackReferenceRange, getRangeDirection, getReferenceRange, referenceRangeMeaning };
package/dist/reference-ranges.d.ts CHANGED
@@ -22,6 +22,35 @@ type SexKey = 'M' | 'F' | 'all';
22
22
  * - `not-required`: valor independe do estado prandial (ex.: HbA1c, TSH).
23
23
  */
24
24
  type FastingRequirement = 'strict' | 'preferred' | 'not-required';
25
+ /**
26
+ * Que tipo de afirmação a faixa faz. As três respondem perguntas diferentes, e
27
+ * uma banda de "faixa normal" que as misture diz coisas diferentes conforme o
28
+ * marcador.
29
+ *
30
+ * - `reference-interval`: o intervalo de referência do ensaio, tirado de uma
31
+ * população de referência saudável (percentis centrais, ou o percentil 99
32
+ * no caso das troponinas). Estar fora dele é estar fora do esperado para
33
+ * quem não tem a doença.
34
+ * - `decision-threshold`: limiar de decisão de diretriz ou de estudo de risco
35
+ * (meta de LDL, corte de pré-diabetes, estágio de DRC). Diz o que fazer, e
36
+ * não como o valor se distribui em gente saudável.
37
+ * - `population`: como o valor se distribui numa população, sem filtrar por
38
+ * saúde (NHANES, coortes de base populacional). Descreve, não julga.
39
+ *
40
+ * Em FHIR, o primeiro vira `normal` e o segundo `recommended` no
41
+ * `referenceRange.type`; o terceiro não tem código próprio no
42
+ * `referencerange-meaning`. Ver `referenceRangeMeaning`.
43
+ */
44
+ type RangeKind = 'reference-interval' | 'decision-threshold' | 'population';
45
+ /**
46
+ * Se um limite da faixa é corte clínico ou está ali para o desenho.
47
+ *
48
+ * `display` é o limite que existe para a faixa ter dois lados no gauge ou na
49
+ * banda, e que não deve virar flag: o teto de 100 mg/dL do HDL, o piso 2 da
50
+ * HbA1c. Ausente quer dizer `clinical`, que é o caso comum e o comportamento
51
+ * de sempre da comparação crua.
52
+ */
53
+ type BoundKind = 'clinical' | 'display';
25
54
  /**
26
55
  * Reference range configuration for a biomarker
27
56
  */
@@ -31,8 +60,17 @@ interface BiomarkerReferenceRange {
31
60
  * consumidores devem aplicar sinalização adequada quando `strict`.
32
61
  */
33
62
  fastingRequired?: FastingRequirement;
63
+ /**
64
+ * Tipo da faixa. Propagado do `BiomarkerRangeDefinition` (ou da variante que
65
+ * casou) no momento da consulta, como o `source`.
66
+ */
67
+ kind?: RangeKind;
34
68
  max?: number;
69
+ /** Ver `BoundKind`. Ausente vale `clinical`. */
70
+ maxKind?: BoundKind;
35
71
  min?: number;
72
+ /** Ver `BoundKind`. Ausente vale `clinical`. */
73
+ minKind?: BoundKind;
36
74
  optimalMax?: number;
37
75
  optimalMin?: number;
38
76
  /**
@@ -67,6 +105,11 @@ type PregnancyTrimester = 1 | 2 | 3;
67
105
  interface RangeVariant {
68
106
  ageMax?: number;
69
107
  ageMin?: number;
108
+ /**
109
+ * Tipo da faixa desta variante, quando ela vem de outra fonte que a da
110
+ * definição. Ausente herda o `kind` da definição.
111
+ */
112
+ kind?: RangeKind;
70
113
  pregnancyTrimester?: PregnancyTrimester;
71
114
  /**
72
115
  * Quando `true`, a variante só se aplica a contextos de gestação.
@@ -88,7 +131,21 @@ interface RangeVariant {
88
131
  type RangeDirection = 'range' | 'higher-better' | 'lower-better';
89
132
  interface BiomarkerRangeDefinition {
90
133
  default: BiomarkerReferenceRange;
134
+ /**
135
+ * Para que lado o marcador melhora. Serve à cor e ao gauge.
136
+ *
137
+ * Não decide flag: se um limite é corte clínico é o `minKind`/`maxKind` da
138
+ * faixa que diz, e quem compara valor com faixa usa `flagAgainstCatalogRange`.
139
+ * Até a 0.33 o `direction` fazia os dois trabalhos, e eles se separam na
140
+ * composição corporal: o `BodyFatPct` é `lower-better` e o piso dele é
141
+ * clínico.
142
+ */
91
143
  direction?: RangeDirection;
144
+ /**
145
+ * Tipo da faixa. Opcional no tipo para não quebrar quem monta definições
146
+ * próprias; todo o catálogo declara, e um teste garante.
147
+ */
148
+ kind?: RangeKind;
92
149
  /**
93
150
  * Chave de fonte bibliográfica, opcionalmente com localizador.
94
151
  *
@@ -141,6 +198,31 @@ declare function getReferenceRange(testCode: string, context?: ReferenceRangeCon
141
198
  * Returns 'range' (default) if not specified.
142
199
  */
143
200
  declare function getRangeDirection(testCode: string): RangeDirection;
201
+ /**
202
+ * A flag de um valor contra a faixa do catálogo, só pelos limites clínicos.
203
+ *
204
+ * Compara contra a faixa que o `getReferenceRange` devolve para o contexto, e
205
+ * ignora o limite marcado como `display`. Não olha o `direction`: o HDL de 105
206
+ * sai sem flag porque o teto de 100 é `display`, e o `BodyFatPct` de 8% sai
207
+ * `L` porque o piso é clínico, embora o marcador seja `lower-better`.
208
+ *
209
+ * **Só serve para a faixa do catálogo.** Faixa que o laboratório imprimiu é
210
+ * afirmação dele sobre aquela amostra, e a comparação contra ela é crua.
211
+ *
212
+ * Devolve `''` quando o código não tem faixa ou o valor está dentro dela.
213
+ */
214
+ declare function flagAgainstCatalogRange(testCode: string, value: number, context?: ReferenceRangeContext): 'H' | 'L' | '';
215
+ /**
216
+ * O `referenceRange.type` do FHIR para um tipo de faixa.
217
+ *
218
+ * `population` não tem código no `referencerange-meaning`, e a função devolve
219
+ * `undefined` em vez de escolher um parecido.
220
+ */
221
+ declare function referenceRangeMeaning(kind: RangeKind): {
222
+ code: 'normal' | 'recommended';
223
+ display: string;
224
+ system: string;
225
+ } | undefined;
144
226
  /**
145
227
  * Get fallback reference range for a biomarker code (default only, no personalization)
146
228
  * Used by API when LLM doesn't extract reference values
@@ -164,4 +246,4 @@ declare function applyFallbackReferenceRanges<T extends {
164
246
  unit?: string;
165
247
  }>(biomarkers: T[]): number;
166
248
 
167
- export { type BiomarkerRangeDefinition, type BiomarkerReferenceRange, type FastingRequirement, type PregnancyTrimester, type RangeDirection, type RangeVariant, type ReferenceRangeContext, type SexKey, applyFallbackReferenceRanges, biomarkerRangeDefinitions, defaultReferenceRanges, getFallbackReferenceRange, getRangeDirection, getReferenceRange };
249
+ export { type BiomarkerRangeDefinition, type BiomarkerReferenceRange, type BoundKind, type FastingRequirement, type PregnancyTrimester, type RangeDirection, type RangeKind, type RangeVariant, type ReferenceRangeContext, type SexKey, applyFallbackReferenceRanges, biomarkerRangeDefinitions, defaultReferenceRanges, flagAgainstCatalogRange, getFallbackReferenceRange, getRangeDirection, getReferenceRange, referenceRangeMeaning };
package/dist/reference-ranges.js CHANGED
@@ -2,18 +2,22 @@ import {
2
2
  applyFallbackReferenceRanges,
3
3
  biomarkerRangeDefinitions,
4
4
  defaultReferenceRanges,
5
+ flagAgainstCatalogRange,
5
6
  getFallbackReferenceRange,
6
7
  getRangeDirection,
7
- getReferenceRange
8
- } from "./chunk-WXCX5TJJ.js";
8
+ getReferenceRange,
9
+ referenceRangeMeaning
10
+ } from "./chunk-P4G534AQ.js";
9
11
  import "./chunk-Q3H5C6UR.js";
10
12
  import "./chunk-4FKZG5GZ.js";
11
13
  export {
12
14
  applyFallbackReferenceRanges,
13
15
  biomarkerRangeDefinitions,
14
16
  defaultReferenceRanges,
17
+ flagAgainstCatalogRange,
15
18
  getFallbackReferenceRange,
16
19
  getRangeDirection,
17
- getReferenceRange
20
+ getReferenceRange,
21
+ referenceRangeMeaning
18
22
  };
19
23
  //# sourceMappingURL=reference-ranges.js.map
package/dist/validators.d.cts CHANGED
@@ -1,4 +1,4 @@
1
- import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-B1KQmlRb.cjs';
1
+ import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-Cn5WFbOI.cjs';
2
2
  import { ImportError } from './importer.cjs';
3
3
 
4
4
  /**
package/dist/validators.d.ts CHANGED
@@ -1,4 +1,4 @@
1
- import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-B1KQmlRb.js';
1
+ import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-Cn5WFbOI.js';
2
2
  import { ImportError } from './importer.js';
3
3
 
4
4
  /**
package/package.json CHANGED
@@ -1,6 +1,6 @@
1
1
  {
2
2
  "name": "@precisa-saude/fhir",
3
- "version": "0.33.0",
3
+ "version": "0.34.0",
4
4
  "description": "Tipos FHIR R4, definições de biomarcadores, faixas de referência e conversores para o ecossistema de saúde brasileiro",
5
5
  "keywords": [
6
6
  "fhir",
package/dist/chunk-FGZXQWSR.cjs.map DELETED
@@ -1 +0,0 @@
1
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Um Bundle com `subject.reference` valendo\n * `Patient/abc` só resolve se alguma entrada tiver `fullUrl` terminando em\n * `/Patient/abc`: a referência relativa é lida contra a base do `fullUrl` da\n * entrada, que é como os exemplos da própria HL7 montam Bundle de coleção.\n *\n * Antes o `fullUrl` era `urn:uuid:observation-<laudo>-<código>`, que erra duas\n * vezes. `urn:uuid:` exige a sintaxe de UUID e aquilo não era um UUID, e num\n * Bundle de entradas `urn:uuid:` a referência precisa repetir a URN inteira,\n * então nenhuma das relativas resolvia. Um laudo de 22 marcadores saía com 24\n * erros de URN e 22 referências perdidas.\n */\n/**\n * Recurso que já tem id, e por isso pode ser endereçado numa entrada.\n *\n * No FHIR o `id` é opcional, porque um recurso pode viajar sem identidade\n * própria. Numa entrada de Bundle ele não pode: sem id não há `fullUrl`, e sem\n * `fullUrl` nenhuma referência chega ao recurso. Os conversores daqui sempre\n * atribuem um, e o tipo passa a dizer isso em vez de deixar `undefined` chegar\n * até a montagem da URL.\n */\nexport type Addressable<T> = T & { id: string };\n\n/**\n * Base dos `fullUrl`.\n *\n * Não precisa responder a uma requisição: no FHIR o `fullUrl` é identidade, não\n * endereço de download. Fica sob um domínio nosso para não colidir com a\n * identidade de recurso de outra instituição, que é o risco real de usar\n * `example.org` em dado que sai da máquina.\n */\nexport const BUNDLE_BASE_URL = 'https://precisa-saude.com.br/fhir';\n\n/**\n * Monta o `fullUrl` a partir do próprio recurso.\n *\n * Recebe o recurso em vez do tipo e do id soltos de propósito. O defeito que\n * isto substitui nasceu de montar os dois lados em separado: o `fullUrl` dizia\n * `observation-demo-Hgb` enquanto o recurso tinha id `demo-Hgb`, e ninguém\n * percebeu porque nada obrigava os dois a concordarem.\n *\n * O parâmetro pede o mínimo que a URL consome, e não a união de recursos que\n * este pacote converte. Um Bundle pode carregar qualquer recurso do R4, e quem\n * acrescenta uma entrada de um tipo que não está nessa união (um `Specimen`,\n * por exemplo) precisa do mesmo endereço, senão monta o dele e as duas formas\n * divergem outra vez.\n */\nexport const entryFullUrl = (resource: Addressable<{ resourceType: string }>): string =>\n `${BUNDLE_BASE_URL}/${resource.resourceType}/${resource.id}`;\n","/**\n * FHIR Converter\n *\n * Converts lab results to FHIR R4 DiagnosticReport and Observation resources.\n * See: https://hl7.org/fhir/diagnosticreport.html\n */\n\nimport { codeToLoinc } from './biomarkers';\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type {\n FHIRBundle,\n FHIRDiagnosticReport,\n FHIRObservation,\n FHIRPatient,\n FHIRQuantity,\n FHIRReferenceRange,\n} from './fhir-types';\nimport type { Flag, LabObservationData, LabReportData, UserProfileData } from './types';\nimport { getDefaultUnit, resolveUcum } from './units';\n\n// Re-export all types and functions\nexport * from './fhir-types';\n\n/**\n * Convert Flag to FHIR interpretation code\n */\nfunction interpretationCode(flag: Flag): string {\n switch (flag) {\n case 'H':\n return 'H'; // High\n case 'L':\n return 'L'; // Low\n default:\n return 'N'; // Normal\n }\n}\n\n/**\n * Convert Flag to FHIR interpretation display\n */\nfunction interpretationDisplay(flag: Flag): string {\n switch (flag) {\n case 'H':\n return 'High';\n case 'L':\n return 'Low';\n default:\n return 'Normal';\n }\n}\n\n/**\n * O `coding` do sexo, que vai **dentro** do CodeableConcept do `appliesTo`.\n *\n * O nome diz `CODING` e não `APPLIES_TO` de propósito: isto não é o valor do\n * campo, é uma entrada da lista de codificações dele. O embrulho acontece no\n * uso, em `{ coding: [SEX_CODING[sex]] }`.\n *\n * É o `AdministrativeGender`, e não o v3-ObservationInterpretation nem um\n * sistema nosso: um consumidor que já lê `Patient.gender` compara os dois sem\n * tabela de tradução no meio.\n */\nconst SEX_CODING = {\n female: {\n code: 'female',\n display: 'Female',\n system: 'http://hl7.org/fhir/administrative-gender',\n },\n male: { code: 'male', display: 'Male', system: 'http://hl7.org/fhir/administrative-gender' },\n} as const;\n\n/**\n * Monta as faixas de referência do `Observation`.\n *\n * Duas mudanças em relação ao que existia, e as duas são sobre não perder o que\n * o laudo imprimiu.\n *\n * **Um limite só já basta.** Antes a faixa só saía com os dois, e um laudo que\n * publica \"inferior a 190 mg/dL\" ou \"superior a 60 mL/min/1,73m²\" perdia o\n * campo inteiro. O R4 trata `low` e `high` como opcionais independentes e\n * documenta o caso de um lado só, e o importador deste mesmo pacote já lia\n * `low?.value` e `high?.value` com acesso opcional: a assimetria era só do\n * escritor. Ver PRE-430.\n *\n * **Mais de uma faixa, anotada.** Laudo com uma coluna de referência por sexo\n * passa a sair com as duas, cada uma com o seu `appliesTo`, em vez de o\n * pipeline escolher uma sem saber de quem é o exame. Ver PRE-424 e PRE-425.\n */\nconst buildReferenceRanges = (\n observation: LabObservationData,\n quantity: (value: number) => FHIRQuantity,\n): FHIRReferenceRange[] => {\n // Devolve lista, e não uma faixa: o caso sem limite nenhum vira lista vazia\n // em vez de `undefined`, e aí os dois caminhos abaixo se compõem com\n // `flatMap` sem ninguém precisar filtrar nada depois.\n const toRanges = (low?: number, high?: number, sex?: 'female' | 'male'): FHIRReferenceRange[] => {\n if (low === undefined && high === undefined) return [];\n\n return [\n {\n ...(sex === undefined ? {} : { appliesTo: [{ coding: [SEX_CODING[sex]] }] }),\n ...(high === undefined ? {} : { high: quantity(high) }),\n ...(low === undefined ? {} : { low: quantity(low) }),\n },\n ];\n };\n\n // A lista anotada tem precedência: quando ela existe, o par simples é o\n // resumo de uma das colunas e repeti-lo publicaria a mesma faixa duas vezes,\n // uma delas sem dizer a quem se aplica.\n //\n // Lista vazia cai no par simples, igual a ausente, e isso é escolha: as duas\n // dizem \"não tenho faixa anotada\", e tratá-las diferente faria um `[]` vindo\n // de um `.filter()` apagar em silêncio a faixa que o chamador também mandou\n // em `referenceMin` e `referenceMax`.\n if (observation.referenceRanges && observation.referenceRanges.length > 0) {\n return observation.referenceRanges.flatMap((r) => toRanges(r.low, r.high, r.appliesTo));\n }\n\n return toRanges(observation.referenceMin, observation.referenceMax);\n};\n\n/**\n * Convert generic lab observation to FHIR Observation\n */\nexport function labObservationToFHIR(\n observation: LabObservationData,\n patientId: string,\n laboratoryName?: string,\n): Addressable<FHIRObservation> {\n const loincCode = codeToLoinc(observation.biomarkerCode);\n // Use default unit if source unit is empty\n const sourceUnit =\n observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;\n // `system` + `code` só saem quando a unidade resolve em UCUM. Unidade que o\n // pacote não sabe traduzir fica só em `unit`, como texto: afirmar\n // `http://unitsofmeasure.org` sobre `x10^3/mm3` era publicar um código\n // falso, e quem consome o Bundle confiando no system trataria aquilo como\n // UCUM de verdade.\n const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);\n const quantity = (value: number): FHIRQuantity => ({\n ...(ucumUnit ? { code: ucumUnit, system: 'http://unitsofmeasure.org' } : {}),\n ...(sourceUnit ? { unit: sourceUnit } : {}),\n value,\n });\n const isQualitative = observation.isQualitative || typeof observation.value === 'string';\n\n // Base observation structure\n const fhirObs: Addressable<FHIRObservation> = {\n category: [\n {\n coding: [\n {\n code: 'laboratory',\n display: 'Laboratory',\n system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n },\n ],\n },\n ],\n code: {\n // Sem LOINC, o coding LOINC simplesmente não sai. Antes ia `99999-9`,\n // que não é código LOINC nenhum: publicava sob `http://loinc.org` uma\n // afirmação falsa, e quem consumisse o bundle confiando no system\n // trataria aquilo como código de verdade. Composição corporal, densidade\n // óssea e escore de cálcio não têm LOINC, e o certo é a lacuna explícita.\n coding: [\n ...(loincCode\n ? [\n {\n code: loincCode,\n display: observation.biomarkerName,\n system: LOINC_SYSTEM,\n },\n ]\n : []),\n {\n code: observation.biomarkerCode,\n display: observation.biomarkerName,\n system: BIOMARKER_CODE_SYSTEM,\n },\n ],\n text: observation.biomarkerName,\n },\n effectiveDateTime: observation.collectionDate,\n id: `${observation.reportId}-${observation.biomarkerCode}`,\n interpretation: [\n {\n coding: [\n {\n code: interpretationCode(observation.flag),\n display: interpretationDisplay(observation.flag),\n system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n },\n ],\n },\n ],\n performer: laboratoryName ? [{ display: laboratoryName }] : undefined,\n resourceType: 'Observation',\n status: 'final',\n subject: {\n reference: `Patient/${patientId}`,\n },\n };\n\n // Add value based on type (qualitative = string, quantitative = number)\n if (isQualitative) {\n fhirObs.valueString = String(observation.value);\n } else {\n fhirObs.valueQuantity = quantity(observation.value as number);\n\n // Reference range only applies to quantitative values\n const referenceRange = buildReferenceRanges(observation, quantity);\n if (referenceRange.length > 0) fhirObs.referenceRange = referenceRange;\n }\n\n return fhirObs;\n}\n\n/**\n * Convert generic lab report to FHIR DiagnosticReport\n */\nexport function labReportToFHIR(\n report: LabReportData,\n patientId: string,\n observationIds: string[],\n): Addressable<FHIRDiagnosticReport> {\n // Map processing status to FHIR status\n let status: FHIRDiagnosticReport['status'];\n switch (report.processingStatus) {\n case 'complete':\n status = 'final';\n break;\n case 'partial':\n status = 'partial';\n break;\n case 'pending_review':\n status = 'preliminary';\n break;\n default:\n status = 'final';\n }\n\n return {\n category: [\n {\n coding: [\n {\n code: 'LAB',\n display: 'Laboratory',\n system: 'http://terminology.hl7.org/CodeSystem/v2-0074',\n },\n ],\n },\n ],\n code: {\n coding: [\n {\n code: '11502-2', // Laboratory report\n display: 'Laboratory report',\n system: 'http://loinc.org',\n },\n ],\n text: 'Laboratory Results',\n },\n conclusion:\n report.overallStatus === 'NORMAL'\n ? 'All results within normal limits'\n : 'One or more abnormal results detected',\n conclusionCode:\n report.overallStatus === 'ANORMAL'\n ? [\n {\n coding: [\n {\n code: 'A',\n display: 'Abnormal',\n system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n },\n ],\n },\n ]\n : undefined,\n effectiveDateTime: report.collectionDate,\n id: report.reportId,\n issued: report.createdAt,\n performer: report.laboratoryName ? [{ display: report.laboratoryName }] : undefined,\n resourceType: 'DiagnosticReport',\n result: observationIds.map((id) => ({ reference: `Observation/${id}` })),\n status,\n subject: {\n reference: `Patient/${patientId}`,\n },\n };\n}\n\n/**\n * Convert user profile to FHIR Patient\n * NOTE: CPF is intentionally excluded for privacy (LGPD compliance)\n */\nexport function userProfileToFHIR(profile: UserProfileData): Addressable<FHIRPatient> {\n const nameParts = profile.name.split(' ');\n const given = nameParts.slice(0, -1);\n const family = nameParts[nameParts.length - 1] || '';\n\n return {\n address: profile.address\n ? [\n {\n city: profile.address.city,\n country: profile.address.country || 'BR',\n line: [\n profile.address.street && profile.address.number\n ? `${profile.address.street}, ${profile.address.number}`\n : profile.address.street,\n profile.address.complement,\n ].filter(Boolean) as string[],\n postalCode: profile.address.postalCode,\n state: profile.address.state,\n },\n ]\n : undefined,\n birthDate: profile.birthDate,\n gender: profile.gender,\n id: profile.userId,\n name: [\n {\n family,\n given: given.length > 0 ? given : undefined,\n text: profile.name,\n },\n ],\n resourceType: 'Patient',\n telecom:\n [\n ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n ].length > 0\n ? [\n ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n ]\n : undefined,\n };\n}\n\n/**\n * Convert complete lab result to FHIR Bundle\n * This is the main function for exporting lab results to FHIR R4 format\n */\nexport function labResultToFHIRBundle(\n report: LabReportData,\n observations: LabObservationData[],\n userProfile: UserProfileData,\n): FHIRBundle {\n const patientId = userProfile.userId;\n\n // Convert observations\n const fhirObservations = observations.map((obs) => {\n const resource = labObservationToFHIR(\n { ...obs, collectionDate: report.collectionDate },\n patientId,\n report.laboratoryName,\n );\n\n return { fullUrl: entryFullUrl(resource), resource };\n });\n\n // Os ids vêm dos recursos já montados, e não de uma segunda montagem da mesma\n // regra. O `DiagnosticReport.result` aponta para eles, e era aqui que a\n // referência se separava do recurso.\n const observationIds = fhirObservations.map((entry) => entry.resource.id);\n\n // Convert report\n const diagnosticReport = labReportToFHIR(report, patientId, observationIds);\n\n // Convert patient\n const fhirPatient = userProfileToFHIR(userProfile);\n\n return {\n entry: [\n { fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient },\n { fullUrl: entryFullUrl(diagnosticReport), resource: diagnosticReport },\n ...fhirObservations,\n ],\n resourceType: 'Bundle',\n type: 'collection',\n };\n}\n"]}