@precisa-saude/fhir 0.31.6 → 0.33.0

package/dist/chunk-FGZXQWSR.cjs.map

@@ -0,0 +1 @@
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Um Bundle com `subject.reference` valendo\n * `Patient/abc` só resolve se alguma entrada tiver `fullUrl` terminando em\n * `/Patient/abc`: a referência relativa é lida contra a base do `fullUrl` da\n * entrada, que é como os exemplos da própria HL7 montam Bundle de coleção.\n *\n * Antes o `fullUrl` era `urn:uuid:observation-<laudo>-<código>`, que erra duas\n * vezes. `urn:uuid:` exige a sintaxe de UUID e aquilo não era um UUID, e num\n * Bundle de entradas `urn:uuid:` a referência precisa repetir a URN inteira,\n * então nenhuma das relativas resolvia. Um laudo de 22 marcadores saía com 24\n * erros de URN e 22 referências perdidas.\n */\n/**\n * Recurso que já tem id, e por isso pode ser endereçado numa entrada.\n *\n * No FHIR o `id` é opcional, porque um recurso pode viajar sem identidade\n * própria. Numa entrada de Bundle ele não pode: sem id não há `fullUrl`, e sem\n * `fullUrl` nenhuma referência chega ao recurso. Os conversores daqui sempre\n * atribuem um, e o tipo passa a dizer isso em vez de deixar `undefined` chegar\n * até a montagem da URL.\n */\nexport type Addressable<T> = T & { id: string };\n\n/**\n * Base dos `fullUrl`.\n *\n * Não precisa responder a uma requisição: no FHIR o `fullUrl` é identidade, não\n * endereço de download. Fica sob um domínio nosso para não colidir com a\n * identidade de recurso de outra instituição, que é o risco real de usar\n * `example.org` em dado que sai da máquina.\n */\nexport const BUNDLE_BASE_URL = 'https://precisa-saude.com.br/fhir';\n\n/**\n * Monta o `fullUrl` a partir do próprio recurso.\n *\n * Recebe o recurso em vez do tipo e do id soltos de propósito. O defeito que\n * isto substitui nasceu de montar os dois lados em separado: o `fullUrl` dizia\n * `observation-demo-Hgb` enquanto o recurso tinha id `demo-Hgb`, e ninguém\n * percebeu porque nada obrigava os dois a concordarem.\n *\n * O parâmetro pede o mínimo que a URL consome, e não a união de recursos que\n * este pacote converte. Um Bundle pode carregar qualquer recurso do R4, e quem\n * acrescenta uma entrada de um tipo que não está nessa união (um `Specimen`,\n * por exemplo) precisa do mesmo endereço, senão monta o dele e as duas formas\n * divergem outra vez.\n */\nexport const entryFullUrl = (resource: Addressable<{ resourceType: string }>): string =>\n  `${BUNDLE_BASE_URL}/${resource.resourceType}/${resource.id}`;\n","/**\n * FHIR Converter\n *\n * Converts lab results to FHIR R4 DiagnosticReport and Observation resources.\n * See: https://hl7.org/fhir/diagnosticreport.html\n */\n\nimport { codeToLoinc } from './biomarkers';\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type {\n  FHIRBundle,\n  FHIRDiagnosticReport,\n  FHIRObservation,\n  FHIRPatient,\n  FHIRQuantity,\n  FHIRReferenceRange,\n} from './fhir-types';\nimport type { Flag, LabObservationData, LabReportData, UserProfileData } from './types';\nimport { getDefaultUnit, resolveUcum } from './units';\n\n// Re-export all types and functions\nexport * from './fhir-types';\n\n/**\n * Convert Flag to FHIR interpretation code\n */\nfunction interpretationCode(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'H'; // High\n    case 'L':\n      return 'L'; // Low\n    default:\n      return 'N'; // Normal\n  }\n}\n\n/**\n * Convert Flag to FHIR interpretation display\n */\nfunction interpretationDisplay(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'High';\n    case 'L':\n      return 'Low';\n    default:\n      return 'Normal';\n  }\n}\n\n/**\n * O `coding` do sexo, que vai **dentro** do CodeableConcept do `appliesTo`.\n *\n * O nome diz `CODING` e não `APPLIES_TO` de propósito: isto não é o valor do\n * campo, é uma entrada da lista de codificações dele. O embrulho acontece no\n * uso, em `{ coding: [SEX_CODING[sex]] }`.\n *\n * É o `AdministrativeGender`, e não o v3-ObservationInterpretation nem um\n * sistema nosso: um consumidor que já lê `Patient.gender` compara os dois sem\n * tabela de tradução no meio.\n */\nconst SEX_CODING = {\n  female: {\n    code: 'female',\n    display: 'Female',\n    system: 'http://hl7.org/fhir/administrative-gender',\n  },\n  male: { code: 'male', display: 'Male', system: 'http://hl7.org/fhir/administrative-gender' },\n} as const;\n\n/**\n * Monta as faixas de referência do `Observation`.\n *\n * Duas mudanças em relação ao que existia, e as duas são sobre não perder o que\n * o laudo imprimiu.\n *\n * **Um limite só já basta.** Antes a faixa só saía com os dois, e um laudo que\n * publica \"inferior a 190 mg/dL\" ou \"superior a 60 mL/min/1,73m²\" perdia o\n * campo inteiro. O R4 trata `low` e `high` como opcionais independentes e\n * documenta o caso de um lado só, e o importador deste mesmo pacote já lia\n * `low?.value` e `high?.value` com acesso opcional: a assimetria era só do\n * escritor. Ver PRE-430.\n *\n * **Mais de uma faixa, anotada.** Laudo com uma coluna de referência por sexo\n * passa a sair com as duas, cada uma com o seu `appliesTo`, em vez de o\n * pipeline escolher uma sem saber de quem é o exame. Ver PRE-424 e PRE-425.\n */\nconst buildReferenceRanges = (\n  observation: LabObservationData,\n  quantity: (value: number) => FHIRQuantity,\n): FHIRReferenceRange[] => {\n  // Devolve lista, e não uma faixa: o caso sem limite nenhum vira lista vazia\n  // em vez de `undefined`, e aí os dois caminhos abaixo se compõem com\n  // `flatMap` sem ninguém precisar filtrar nada depois.\n  const toRanges = (low?: number, high?: number, sex?: 'female' | 'male'): FHIRReferenceRange[] => {\n    if (low === undefined && high === undefined) return [];\n\n    return [\n      {\n        ...(sex === undefined ? {} : { appliesTo: [{ coding: [SEX_CODING[sex]] }] }),\n        ...(high === undefined ? {} : { high: quantity(high) }),\n        ...(low === undefined ? {} : { low: quantity(low) }),\n      },\n    ];\n  };\n\n  // A lista anotada tem precedência: quando ela existe, o par simples é o\n  // resumo de uma das colunas e repeti-lo publicaria a mesma faixa duas vezes,\n  // uma delas sem dizer a quem se aplica.\n  //\n  // Lista vazia cai no par simples, igual a ausente, e isso é escolha: as duas\n  // dizem \"não tenho faixa anotada\", e tratá-las diferente faria um `[]` vindo\n  // de um `.filter()` apagar em silêncio a faixa que o chamador também mandou\n  // em `referenceMin` e `referenceMax`.\n  if (observation.referenceRanges && observation.referenceRanges.length > 0) {\n    return observation.referenceRanges.flatMap((r) => toRanges(r.low, r.high, r.appliesTo));\n  }\n\n  return toRanges(observation.referenceMin, observation.referenceMax);\n};\n\n/**\n * Convert generic lab observation to FHIR Observation\n */\nexport function labObservationToFHIR(\n  observation: LabObservationData,\n  patientId: string,\n  laboratoryName?: string,\n): Addressable<FHIRObservation> {\n  const loincCode = codeToLoinc(observation.biomarkerCode);\n  // Use default unit if source unit is empty\n  const sourceUnit =\n    observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;\n  // `system` + `code` só saem quando a unidade resolve em UCUM. Unidade que o\n  // pacote não sabe traduzir fica só em `unit`, como texto: afirmar\n  // `http://unitsofmeasure.org` sobre `x10^3/mm3` era publicar um código\n  // falso, e quem consome o Bundle confiando no system trataria aquilo como\n  // UCUM de verdade.\n  const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);\n  const quantity = (value: number): FHIRQuantity => ({\n    ...(ucumUnit ? { code: ucumUnit, system: 'http://unitsofmeasure.org' } : {}),\n    ...(sourceUnit ? { unit: sourceUnit } : {}),\n    value,\n  });\n  const isQualitative = observation.isQualitative || typeof observation.value === 'string';\n\n  // Base observation structure\n  const fhirObs: Addressable<FHIRObservation> = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'laboratory',\n            display: 'Laboratory',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      // Sem LOINC, o coding LOINC simplesmente não sai. Antes ia `99999-9`,\n      // que não é código LOINC nenhum: publicava sob `http://loinc.org` uma\n      // afirmação falsa, e quem consumisse o bundle confiando no system\n      // trataria aquilo como código de verdade. Composição corporal, densidade\n      // óssea e escore de cálcio não têm LOINC, e o certo é a lacuna explícita.\n      coding: [\n        ...(loincCode\n          ? [\n              {\n                code: loincCode,\n                display: observation.biomarkerName,\n                system: LOINC_SYSTEM,\n              },\n            ]\n          : []),\n        {\n          code: observation.biomarkerCode,\n          display: observation.biomarkerName,\n          system: BIOMARKER_CODE_SYSTEM,\n        },\n      ],\n      text: observation.biomarkerName,\n    },\n    effectiveDateTime: observation.collectionDate,\n    id: `${observation.reportId}-${observation.biomarkerCode}`,\n    interpretation: [\n      {\n        coding: [\n          {\n            code: interpretationCode(observation.flag),\n            display: interpretationDisplay(observation.flag),\n            system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n          },\n        ],\n      },\n    ],\n    performer: laboratoryName ? [{ display: laboratoryName }] : undefined,\n    resourceType: 'Observation',\n    status: 'final',\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n\n  // Add value based on type (qualitative = string, quantitative = number)\n  if (isQualitative) {\n    fhirObs.valueString = String(observation.value);\n  } else {\n    fhirObs.valueQuantity = quantity(observation.value as number);\n\n    // Reference range only applies to quantitative values\n    const referenceRange = buildReferenceRanges(observation, quantity);\n    if (referenceRange.length > 0) fhirObs.referenceRange = referenceRange;\n  }\n\n  return fhirObs;\n}\n\n/**\n * Convert generic lab report to FHIR DiagnosticReport\n */\nexport function labReportToFHIR(\n  report: LabReportData,\n  patientId: string,\n  observationIds: string[],\n): Addressable<FHIRDiagnosticReport> {\n  // Map processing status to FHIR status\n  let status: FHIRDiagnosticReport['status'];\n  switch (report.processingStatus) {\n    case 'complete':\n      status = 'final';\n      break;\n    case 'partial':\n      status = 'partial';\n      break;\n    case 'pending_review':\n      status = 'preliminary';\n      break;\n    default:\n      status = 'final';\n  }\n\n  return {\n    category: [\n      {\n        coding: [\n          {\n            code: 'LAB',\n            display: 'Laboratory',\n            system: 'http://terminology.hl7.org/CodeSystem/v2-0074',\n          },\n        ],\n      },\n    ],\n    code: {\n      coding: [\n        {\n          code: '11502-2', // Laboratory report\n          display: 'Laboratory report',\n          system: 'http://loinc.org',\n        },\n      ],\n      text: 'Laboratory Results',\n    },\n    conclusion:\n      report.overallStatus === 'NORMAL'\n        ? 'All results within normal limits'\n        : 'One or more abnormal results detected',\n    conclusionCode:\n      report.overallStatus === 'ANORMAL'\n        ? [\n            {\n              coding: [\n                {\n                  code: 'A',\n                  display: 'Abnormal',\n                  system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n                },\n              ],\n            },\n          ]\n        : undefined,\n    effectiveDateTime: report.collectionDate,\n    id: report.reportId,\n    issued: report.createdAt,\n    performer: report.laboratoryName ? [{ display: report.laboratoryName }] : undefined,\n    resourceType: 'DiagnosticReport',\n    result: observationIds.map((id) => ({ reference: `Observation/${id}` })),\n    status,\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n}\n\n/**\n * Convert user profile to FHIR Patient\n * NOTE: CPF is intentionally excluded for privacy (LGPD compliance)\n */\nexport function userProfileToFHIR(profile: UserProfileData): Addressable<FHIRPatient> {\n  const nameParts = profile.name.split(' ');\n  const given = nameParts.slice(0, -1);\n  const family = nameParts[nameParts.length - 1] || '';\n\n  return {\n    address: profile.address\n      ? [\n          {\n            city: profile.address.city,\n            country: profile.address.country || 'BR',\n            line: [\n              profile.address.street && profile.address.number\n                ? `${profile.address.street}, ${profile.address.number}`\n                : profile.address.street,\n              profile.address.complement,\n            ].filter(Boolean) as string[],\n            postalCode: profile.address.postalCode,\n            state: profile.address.state,\n          },\n        ]\n      : undefined,\n    birthDate: profile.birthDate,\n    gender: profile.gender,\n    id: profile.userId,\n    name: [\n      {\n        family,\n        given: given.length > 0 ? given : undefined,\n        text: profile.name,\n      },\n    ],\n    resourceType: 'Patient',\n    telecom:\n      [\n        ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n        ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n      ].length > 0\n        ? [\n            ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n            ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n          ]\n        : undefined,\n  };\n}\n\n/**\n * Convert complete lab result to FHIR Bundle\n * This is the main function for exporting lab results to FHIR R4 format\n */\nexport function labResultToFHIRBundle(\n  report: LabReportData,\n  observations: LabObservationData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n\n  // Convert observations\n  const fhirObservations = observations.map((obs) => {\n    const resource = labObservationToFHIR(\n      { ...obs, collectionDate: report.collectionDate },\n      patientId,\n      report.laboratoryName,\n    );\n\n    return { fullUrl: entryFullUrl(resource), resource };\n  });\n\n  // Os ids vêm dos recursos já montados, e não de uma segunda montagem da mesma\n  // regra. O `DiagnosticReport.result` aponta para eles, e era aqui que a\n  // referência se separava do recurso.\n  const observationIds = fhirObservations.map((entry) => entry.resource.id);\n\n  // Convert report\n  const diagnosticReport = labReportToFHIR(report, patientId, observationIds);\n\n  // Convert patient\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  return {\n    entry: [\n      { fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient },\n      { fullUrl: entryFullUrl(diagnosticReport), resource: diagnosticReport },\n      ...fhirObservations,\n    ],\n    resourceType: 'Bundle',\n    type: 'collection',\n  };\n}\n"]}

package/dist/chunk-HQ26GOLI.js

@@ -0,0 +1,342 @@
+// src/sources.ts
+var SOURCE_REGISTRY = {
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Cardiovascular
+  // ---------------------------------------------------------------------------
+  "agatston-1990": {
+    abnt: "AGATSTON, A. S. et al. Quantification of coronary artery calcium using ultrafast computed tomography. Journal of the American College of Cardiology, v. 15, n. 4, p. 827-832, 1990.",
+    doi: "10.1016/0735-1097(90)90282-T",
+    key: "agatston-1990",
+    url: "https://pubmed.ncbi.nlm.nih.gov/2407762/"
+  },
+  "browning-ashwell-2010": {
+    abnt: "BROWNING, L. M.; HSIEH, S. D.; ASHWELL, M. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0,5 could be a suitable global boundary value. Nutrition Research Reviews, v. 23, n. 2, p. 247-269, 2010.",
+    doi: "10.1017/S0954422410000144",
+    key: "browning-ashwell-2010",
+    url: "https://pubmed.ncbi.nlm.nih.gov/20819243/"
+  },
+  "castelli-ratio-1992": {
+    abnt: "CASTELLI, W. P. et al. Lipids and risk of coronary heart disease: the Framingham Study. Annals of Epidemiology, v. 2, n. 1-2, p. 23-28, 1992.",
+    doi: "10.1016/1047-2797(92)90033-M",
+    key: "castelli-ratio-1992",
+    url: "https://pubmed.ncbi.nlm.nih.gov/1342260/"
+  },
+  "caulfield-ionmobility-2008": {
+    abnt: "CAULFIELD, M. P. et al. Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clinical Chemistry, v. 54, n. 8, p. 1307-1316, 2008.",
+    doi: "10.1373/clinchem.2007.100586",
+    key: "caulfield-ionmobility-2008",
+    url: "https://pubmed.ncbi.nlm.nih.gov/18515257/"
+  },
+  "contois-apoa1-1996": {
+    abnt: "CONTOIS, J. H. et al. Reference intervals for plasma apolipoprotein A-1 determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study. Clinical Chemistry, v. 42, n. 4, p. 507-514, 1996.",
+    doi: "10.1093/clinchem/42.4.507",
+    key: "contois-apoa1-1996",
+    url: "https://pubmed.ncbi.nlm.nih.gov/8605666/"
+  },
+  "ewgsop2-2019": {
+    abnt: "CRUZ-JENTOFT, A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, v. 48, n. 1, p. 16-31, 2019.",
+    doi: "10.1093/ageing/afy169",
+    key: "ewgsop2-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/30312372/"
+  },
+  "ferreira-vitd-2017": {
+    abnt: "FERREIRA, C. E. S. et al. Posicionamento oficial da Sociedade Brasileira de Patologia Cl\xEDnica/Medicina Laboratorial e da Sociedade Brasileira de Endocrinologia e Metabologia sobre intervalos de refer\xEAncia da vitamina D [25(OH)D]. Archives of Endocrinology and Metabolism, v. 61, n. 6, p. 527-542, 2017.",
+    doi: "10.1590/2359-3997000000310",
+    key: "ferreira-vitd-2017",
+    url: "https://pubmed.ncbi.nlm.nih.gov/29412389/"
+  },
+  "friedewald-1972": {
+    abnt: "FRIEDEWALD, W. T.; LEVY, R. I.; FREDRICKSON, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, v. 18, n. 6, p. 499-502, 1972.",
+    doi: "10.1093/clinchem/18.6.499",
+    key: "friedewald-1972",
+    url: "https://pubmed.ncbi.nlm.nih.gov/4337382/"
+  },
+  "gallagher-bodyfat-2000": {
+    abnt: "GALLAGHER, D. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. American Journal of Clinical Nutrition, v. 72, n. 3, p. 694-701, 2000.",
+    key: "gallagher-bodyfat-2000",
+    url: "https://pubmed.ncbi.nlm.nih.gov/10966886/"
+  },
+  "ge-corescan": {
+    abnt: "GE HEALTHCARE. enCORE Software CoreScan: Visceral Adipose Tissue (VAT) assessment. Madison: GE Medical Systems Lunar, [s. d.]. (Documenta\xE7\xE3o do fabricante do DEXA Lunar Prodigy; classifica\xE7\xE3o Healthy 0\u201352 in\xB3, Increased Risk 52,15\u2013112,10 in\xB3, At Risk 112,10+ in\xB3, equivalente a 0\u2013852 cm\xB3, 854\u20131.837 cm\xB3, 1.837+ cm\xB3.)",
+    key: "ge-corescan",
+    url: "https://www.gehealthcare.com/products/bone-and-metabolic-health/encore"
+  },
+  "geloneze-brams-2009": {
+    abnt: "GELONEZE, B. et al. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome \u2014 Brazilian Metabolic Syndrome Study (BRAMS). Arquivos Brasileiros de Endocrinologia & Metabologia, v. 53, n. 2, p. 281-287, 2009.",
+    doi: "10.1590/S0004-27302009000200020",
+    key: "geloneze-brams-2009",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19466221/"
+  },
+  "george-ck-2016": {
+    abnt: "GEORGE, M. D.; MCGILL, N. K.; BAKER, J. F. Creatine kinase in the U.S. population: impact of demographics, comorbidities, and body composition on the normal range. Medicine, v. 95, n. 33, e4344, 2016.",
+    doi: "10.1097/MD.0000000000004344",
+    key: "george-ck-2016",
+    url: "https://pubmed.ncbi.nlm.nih.gov/27537560/"
+  },
+  "giannitsis-hstnt-2010": {
+    abnt: "GIANNITSIS, E. et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clinical Chemistry, v. 56, n. 2, p. 254-261, 2010.",
+    doi: "10.1373/clinchem.2009.132654",
+    key: "giannitsis-hstnt-2010",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19959623/"
+  },
+  "glis-2024": {
+    abnt: "KIRK, B. et al. The conceptual definition of sarcopenia: Delphi consensus from the Global Leadership Initiative in Sarcopenia (GLIS). Age and Ageing, v. 53, n. 3, afae052, 2024.",
+    doi: "10.1093/ageing/afae052",
+    key: "glis-2024",
+    url: "https://pubmed.ncbi.nlm.nih.gov/38520141/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Ácidos graxos ômega
+  // ---------------------------------------------------------------------------
+  "harris-omega3-2004": {
+    abnt: "HARRIS, W. S.; VON SCHACKY, C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine, v. 39, n. 1, p. 212-220, 2004.",
+    doi: "10.1016/j.ypmed.2004.02.030",
+    key: "harris-omega3-2004",
+    url: "https://pubmed.ncbi.nlm.nih.gov/15208005/"
+  },
+  // ---------------------------------------------------------------------------
+  // Referência laboratorial geral
+  // ---------------------------------------------------------------------------
+  "kalaria-ck-ri-2026": {
+    abnt: "KALARIA, T. et al. Age, sex and ethnicity changes in creatine kinase and sex- and ethnicity-specific reference intervals of creatine kinase. Clinical Medicine, v. 26, n. 4, p. 100596, 2026.",
+    doi: "10.1016/j.clinme.2026.100596",
+    key: "kalaria-ck-ri-2026",
+    url: "https://pubmed.ncbi.nlm.nih.gov/42142664/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Nefrologia
+  // ---------------------------------------------------------------------------
+  "kdigo-ckd-2024": {
+    abnt: "KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International, v. 105, n. 4S, p. S117-S314, 2024.",
+    doi: "10.1016/j.kint.2023.10.018",
+    key: "kdigo-ckd-2024",
+    url: "https://pubmed.ncbi.nlm.nih.gov/38490803/"
+  },
+  "keller-tni-2013": {
+    abnt: "KELLER, T. et al. Defining a reference population to determine the 99th percentile of a contemporary sensitive cardiac troponin I assay. International Journal of Cardiology, v. 167, n. 4, p. 1423-1429, 2013.",
+    doi: "10.1016/j.ijcard.2012.04.063",
+    key: "keller-tni-2013",
+    url: "https://pubmed.ncbi.nlm.nih.gov/22560907/"
+  },
+  "kelly-dxa-2009": {
+    abnt: "KELLY, T. L. et al. Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS One, v. 4, n. 9, e7038, 2009.",
+    doi: "10.1371/journal.pone.0007038",
+    key: "kelly-dxa-2009",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19753111/"
+  },
+  "khetarpal-apociii-2016": {
+    abnt: "KHETARPAL, S. A. et al. Why is apolipoprotein CIII emerging as a novel therapeutic target to reduce the burden of cardiovascular disease? Current Atherosclerosis Reports, v. 18, n. 10, p. 59, 2016.",
+    key: "khetarpal-apociii-2016",
+    url: "https://pmc.ncbi.nlm.nih.gov/articles/PMC5018018/"
+  },
+  "klee-bhb-2020": {
+    abnt: "KLEE, P. et al. Test validation, method comparison and reference range for the measurement of \u03B2-hydroxybutyrate in peripheral blood samples. Practical Laboratory Medicine, v. 18, e00146, 2020.",
+    doi: "10.1016/j.plabm.2019.e00146",
+    key: "klee-bhb-2020",
+    url: "https://pmc.ncbi.nlm.nih.gov/articles/PMC6999181/"
+  },
+  "maisel-bnp-2002": {
+    abnt: "MAISEL, A. S. et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. New England Journal of Medicine, v. 347, n. 3, p. 161-167, 2002.",
+    doi: "10.1056/NEJMoa020233",
+    key: "maisel-bnp-2002",
+    url: "https://pubmed.ncbi.nlm.nih.gov/12124404/"
+  },
+  "meuwese-mpo-2007": {
+    abnt: "MEUWESE, M. C. et al. Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study. Journal of the American College of Cardiology, v. 50, n. 2, p. 159-165, 2007.",
+    doi: "10.1016/j.jacc.2007.03.033",
+    key: "meuwese-mpo-2007",
+    url: "https://pubmed.ncbi.nlm.nih.gov/17616301/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Marcadores metabólicos e inflamatórios
+  // ---------------------------------------------------------------------------
+  "nemeth-adma-2017": {
+    abnt: "NEMETH, B. et al. The issue of plasma asymmetric dimethylarginine reference range: a systematic review and meta-analysis. PLoS One, v. 12, n. 5, e0177493, 2017.",
+    doi: "10.1371/journal.pone.0177493",
+    key: "nemeth-adma-2017",
+    url: "https://pubmed.ncbi.nlm.nih.gov/28494019/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes brasileiras — Metais pesados (NR-7)
+  // ---------------------------------------------------------------------------
+  "nr7-pcmso-2020": {
+    abnt: "BRASIL. Minist\xE9rio do Trabalho e Emprego. NR-7 \u2014 PCMSO, Quadro 1: Indicadores biol\xF3gicos. Portaria n. 6.734, de 9 de mar\xE7o de 2020. Di\xE1rio Oficial da Uni\xE3o, Bras\xEDlia, 13 mar. 2020.",
+    key: "nr7-pcmso-2020",
+    url: "https://www.gov.br/trabalho-e-emprego/pt-br/assuntos/inspecao-do-trabalho/seguranca-e-saude-no-trabalho/sst-portarias/2022/portaria-no-567-de-10-de-marco-de-2022-alteracoes-na-nr-7.pdf"
+  },
+  "ofenheimer-vat-2020": {
+    abnt: "OFENHEIMER, A. et al. Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18-81 years: results from the LEAD cohort. European Journal of Clinical Nutrition, v. 74, p. 1181-1191, 2020.",
+    doi: "10.1038/s41430-020-0596-5",
+    key: "ofenheimer-vat-2020",
+    url: "https://pubmed.ncbi.nlm.nih.gov/32123345/"
+  },
+  "pns-bioquimica-2019": {
+    abnt: "SZWARCWALD, C. L. et al. Valores de refer\xEAncia para exames laboratoriais de colesterol, hemoglobina glicosilada e creatinina da popula\xE7\xE3o adulta brasileira. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190002.supl.2, 2019.",
+    doi: "10.1590/1980-549720190002.supl.2",
+    key: "pns-bioquimica-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/31596373/"
+  },
+  // ---------------------------------------------------------------------------
+  // Pesquisa Nacional de Saúde (PNS) — Intervalos de referência brasileiros
+  // ---------------------------------------------------------------------------
+  "pns-hemograma-2019": {
+    abnt: "ROSENFELD, L. G. et al. Valores de refer\xEAncia para exames laboratoriais de hemograma da popula\xE7\xE3o adulta brasileira: Pesquisa Nacional de Sa\xFAde. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190003.supl.2, 2019.",
+    doi: "10.1590/1980-549720190003.supl.2",
+    key: "pns-hemograma-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/31596374/"
+  },
+  "pns-renal-2019": {
+    abnt: "MALTA, D. C. et al. Evaluation of renal function in the Brazilian adult population, according to laboratory criteria from the National Health Survey. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190010.supl.2, 2019.",
+    doi: "10.1590/1980-549720190010.supl.2",
+    key: "pns-renal-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/31596381/"
+  },
+  "rumberger-cac-1999": {
+    abnt: "RUMBERGER, J. A. et al. Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clinic Proceedings, v. 74, n. 3, p. 243-252, 1999.",
+    doi: "10.4065/74.3.243",
+    key: "rumberger-cac-1999",
+    url: "https://pubmed.ncbi.nlm.nih.gov/10089993/"
+  },
+  "sbc-ic-2018": {
+    abnt: "ROHDE, L. E. P. et al. Diretriz Brasileira de Insufici\xEAncia Card\xEDaca Cr\xF4nica e Aguda. Arquivos Brasileiros de Cardiologia, S\xE3o Paulo, v. 111, n. 3, p. 436-539, set. 2018.",
+    doi: "10.5935/abc.20180190",
+    key: "sbc-ic-2018",
+    url: "https://pubmed.ncbi.nlm.nih.gov/30379264/"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Cardiologia
+  // ---------------------------------------------------------------------------
+  "sbc-lipids-2017": {
+    abnt: "FALUDI, A. A. et al. Atualiza\xE7\xE3o da Diretriz Brasileira de Dislipidemias e Preven\xE7\xE3o da Aterosclerose \u2013 2017. Arquivos Brasileiros de Cardiologia, S\xE3o Paulo, v. 109, n. 2, supl. 1, p. 1-76, ago. 2017.",
+    doi: "10.5935/abc.20170121",
+    key: "sbc-lipids-2017",
+    url: "https://www.scielo.br/j/abc/a/whBsCyzTDzGYJcsBY7YVkWn/?lang=pt"
+  },
+  "sbc-lipids-2025": {
+    abnt: "RACHED, F. H. et al. Diretriz Brasileira de Dislipidemias e Preven\xE7\xE3o da Aterosclerose \u2013 2025. Arquivos Brasileiros de Cardiologia, S\xE3o Paulo, v. 122, n. 9, e20250640, out. 2025.",
+    doi: "10.36660/abc.20250640",
+    key: "sbc-lipids-2025",
+    url: "https://pmc.ncbi.nlm.nih.gov/articles/PMC12674852/"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Diabetes
+  // ---------------------------------------------------------------------------
+  "sbd-diabetes-2024": {
+    // Chave mantida como 'sbd-diabetes-2024' para compatibilidade com
+    // consumidores publicados; a diretriz correspondente é o documento vivo
+    // de diretriz.diabetes.org.br, cuja edição citada quando este registro foi
+    // atualizado é "Edição 2025". Semelhante ao caso de sbpc-ml-2021 abaixo.
+    abnt: "SOCIEDADE BRASILEIRA DE DIABETES (SBD). Diretriz da Sociedade Brasileira de Diabetes \u2014 Edi\xE7\xE3o 2025. S\xE3o Paulo: SBD, 2025.",
+    doi: "10.29327/5660187",
+    isbn: "978-65-272-1932-3",
+    key: "sbd-diabetes-2024",
+    url: "https://diretriz.diabetes.org.br"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Endocrinologia e Metabologia
+  // ---------------------------------------------------------------------------
+  "sbem-thyroid-2013": {
+    abnt: "SGARBI, J. A. et al. Consenso brasileiro para a abordagem cl\xEDnica e tratamento do hipotireoidismo subcl\xEDnico em adultos. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 57, n. 3, p. 166-183, 2013.",
+    doi: "10.1590/S0004-27302013000300003",
+    key: "sbem-thyroid-2013",
+    url: "https://pubmed.ncbi.nlm.nih.gov/23681263/"
+  },
+  "sbem-vitamind-2014": {
+    abnt: "MAEDA, S. S. et al. Recomenda\xE7\xF5es da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagn\xF3stico e tratamento da hipovitaminose D. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 58, n. 5, p. 411-433, 2014.",
+    doi: "10.1590/0004-2730000003388",
+    key: "sbem-vitamind-2014",
+    url: "https://pubmed.ncbi.nlm.nih.gov/25166032/"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Patologia Clínica / Medicina Laboratorial
+  // ---------------------------------------------------------------------------
+  "sbpc-ml-2021": {
+    // Chave mantida como 'sbpc-ml-2021' para compatibilidade com consumidores;
+    // a edição autoritativa é de 2020 (verificada na Biblioteca Digital SBPC/ML
+    // em 2026-04-18). Ano na citação ABNT reflete a edição real.
+    abnt: "SOCIEDADE BRASILEIRA DE PATOLOGIA CL\xCDNICA/MEDICINA LABORATORIAL (SBPC/ML). Recomenda\xE7\xF5es da Sociedade Brasileira de Patologia Cl\xEDnica/Medicina Laboratorial (SBPC/ML): Boas Pr\xE1ticas em Laborat\xF3rio Cl\xEDnico. S\xE3o Paulo: SBPC/ML, 2020.",
+    key: "sbpc-ml-2021",
+    url: "https://bibliotecasbpc.org.br/index.php?P=4&C=0.2.443"
+  },
+  "schumann-ifcc-ldh-2002": {
+    abnt: "SCHUMANN, G.; KLAUKE, R. New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects. Clinica Chimica Acta, v. 327, n. 1-2, p. 69-79, 2003.",
+    doi: "10.1016/S0009-8981(02)00341-8",
+    key: "schumann-ifcc-ldh-2002",
+    url: "https://pubmed.ncbi.nlm.nih.gov/12482620/"
+  },
+  "schwedhelm-sdma-2011": {
+    abnt: "SCHWEDHELM, E. et al. Plasma symmetric dimethylarginine reference limits from the Framingham Offspring Cohort. Clinical Chemistry and Laboratory Medicine, v. 49, n. 11, p. 1907-1910, 2011.",
+    doi: "10.1515/CCLM.2011.679",
+    key: "schwedhelm-sdma-2011",
+    url: "https://pubmed.ncbi.nlm.nih.gov/21864208/"
+  },
+  "selhub-homocysteine-1999": {
+    abnt: "SELHUB, J. et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Annals of Internal Medicine, v. 131, n. 5, p. 331-339, 1999.",
+    doi: "10.7326/0003-4819-131-5-199909070-00003",
+    key: "selhub-homocysteine-1999",
+    url: "https://pubmed.ncbi.nlm.nih.gov/10475885/"
+  },
+  "simopoulos-omega-ratio-2002": {
+    abnt: "SIMOPOULOS, A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, v. 56, n. 8, p. 365-379, 2002.",
+    doi: "10.1016/S0753-3322(02)00253-6",
+    key: "simopoulos-omega-ratio-2002",
+    url: "https://pubmed.ncbi.nlm.nih.gov/12442909/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Marcadores tumorais
+  // ---------------------------------------------------------------------------
+  "sturgeon-nacb-2008": {
+    abnt: "STURGEON, C. M. et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clinical Chemistry, v. 54, n. 12, p. e11-e79, 2008.",
+    doi: "10.1373/clinchem.2008.105601",
+    key: "sturgeon-nacb-2008",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19042984/"
+  },
+  "tietz-7ed-2015": {
+    abnt: "BURTIS, C. A.; BRUNS, D. E. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. 7. ed. St. Louis: Elsevier Saunders, 2015.",
+    isbn: "978-1-4557-4165-6",
+    key: "tietz-7ed-2015"
+  },
+  "torrissen-omega3-dbs-2025": {
+    abnt: "TORRISSEN, M. et al. Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples. Lipids in Health and Disease, v. 24, n. 1, p. 260, 2025.",
+    doi: "10.1186/s12944-025-02676-6",
+    key: "torrissen-omega3-dbs-2025",
+    url: "https://pubmed.ncbi.nlm.nih.gov/40783537/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Coagulação
+  // ---------------------------------------------------------------------------
+  "wells-ddimer-2003": {
+    abnt: "WELLS, P. S. et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. New England Journal of Medicine, v. 349, p. 1227-1235, 2003.",
+    doi: "10.1056/NEJMoa023153",
+    key: "wells-ddimer-2003",
+    url: "https://pubmed.ncbi.nlm.nih.gov/14507948/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — OMS
+  // ---------------------------------------------------------------------------
+  "who-iron-2020": {
+    abnt: "WORLD HEALTH ORGANIZATION. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: WHO, 2020.",
+    isbn: "978-92-4-000012-4",
+    key: "who-iron-2020",
+    url: "https://www.who.int/publications/i/item/9789240000124"
+  },
+  "who-obesity-2000": {
+    abnt: "WORLD HEALTH ORGANIZATION. Obesity: preventing and managing the global epidemic. WHO Technical Report Series, n. 894. Geneva: WHO, 2000.",
+    isbn: "92-4-120894-5",
+    key: "who-obesity-2000"
+  },
+  "who-osteoporosis-1994": {
+    abnt: "WHO STUDY GROUP. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series, n. 843. Geneva: WHO, 1994.",
+    key: "who-osteoporosis-1994",
+    url: "https://pubmed.ncbi.nlm.nih.gov/7941614/"
+  }
+};
+function extractSourceKey(source) {
+  return source.split(":")[0] ?? source;
+}
+
+export {
+  SOURCE_REGISTRY,
+  extractSourceKey
+};
+//# sourceMappingURL=chunk-HQ26GOLI.js.map

package/dist/chunk-HQ26GOLI.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/sources.ts"],"sourcesContent":["/**\n * Registro de fontes bibliográficas para faixas de referência de biomarcadores.\n *\n * Exportado na API pública desde a 0.32: o campo `source` de cada faixa é uma\n * chave, e sem o registro ao lado ela não resolve para lugar nenhum. Quem\n * consome via `@precisa-saude/fhir/sources` ou pelo `fhir-bio source`.\n *\n * Todas as citações seguem o formato ABNT (NBR 6023).\n */\n\n/**\n * Referência bibliográfica completa para uma fonte de faixas de referência.\n */\nexport interface SourceReference {\n  /** Citação completa em formato ABNT (NBR 6023) */\n  abnt: string;\n  /** DOI, quando disponível */\n  doi?: string;\n  /** ISBN, quando aplicável */\n  isbn?: string;\n  /** Chave curta usada no campo `source` de BiomarkerRangeDefinition */\n  key: string;\n  /** URL de acesso */\n  url?: string;\n}\n\n/**\n * Registro central de todas as fontes bibliográficas utilizadas nas faixas de referência.\n *\n * Cada chave corresponde ao valor usado no campo `source` de `BiomarkerRangeDefinition`\n * (sem o sufixo de localização, ex: `'sbc-lipids-2017'` sem `':p15'`).\n */\nexport const SOURCE_REGISTRY: Record<string, SourceReference> = {\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Cardiovascular\n  // ---------------------------------------------------------------------------\n  'agatston-1990': {\n    abnt: 'AGATSTON, A. S. et al. Quantification of coronary artery calcium using ultrafast computed tomography. Journal of the American College of Cardiology, v. 15, n. 4, p. 827-832, 1990.',\n    doi: '10.1016/0735-1097(90)90282-T',\n    key: 'agatston-1990',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/2407762/',\n  },\n\n  'browning-ashwell-2010': {\n    abnt: 'BROWNING, L. M.; HSIEH, S. D.; ASHWELL, M. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0,5 could be a suitable global boundary value. Nutrition Research Reviews, v. 23, n. 2, p. 247-269, 2010.',\n    doi: '10.1017/S0954422410000144',\n    key: 'browning-ashwell-2010',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/20819243/',\n  },\n\n  'castelli-ratio-1992': {\n    abnt: 'CASTELLI, W. P. et al. Lipids and risk of coronary heart disease: the Framingham Study. Annals of Epidemiology, v. 2, n. 1-2, p. 23-28, 1992.',\n    doi: '10.1016/1047-2797(92)90033-M',\n    key: 'castelli-ratio-1992',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/1342260/',\n  },\n\n  'caulfield-ionmobility-2008': {\n    abnt: 'CAULFIELD, M. P. et al. Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clinical Chemistry, v. 54, n. 8, p. 1307-1316, 2008.',\n    doi: '10.1373/clinchem.2007.100586',\n    key: 'caulfield-ionmobility-2008',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/18515257/',\n  },\n\n  'contois-apoa1-1996': {\n    abnt: 'CONTOIS, J. H. et al. Reference intervals for plasma apolipoprotein A-1 determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study. Clinical Chemistry, v. 42, n. 4, p. 507-514, 1996.',\n    doi: '10.1093/clinchem/42.4.507',\n    key: 'contois-apoa1-1996',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/8605666/',\n  },\n\n  'ewgsop2-2019': {\n    abnt: 'CRUZ-JENTOFT, A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, v. 48, n. 1, p. 16-31, 2019.',\n    doi: '10.1093/ageing/afy169',\n    key: 'ewgsop2-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/30312372/',\n  },\n\n  'ferreira-vitd-2017': {\n    abnt: 'FERREIRA, C. E. S. et al. Posicionamento oficial da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial e da Sociedade Brasileira de Endocrinologia e Metabologia sobre intervalos de referência da vitamina D [25(OH)D]. Archives of Endocrinology and Metabolism, v. 61, n. 6, p. 527-542, 2017.',\n    doi: '10.1590/2359-3997000000310',\n    key: 'ferreira-vitd-2017',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/29412389/',\n  },\n\n  'friedewald-1972': {\n    abnt: 'FRIEDEWALD, W. T.; LEVY, R. I.; FREDRICKSON, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, v. 18, n. 6, p. 499-502, 1972.',\n    doi: '10.1093/clinchem/18.6.499',\n    key: 'friedewald-1972',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/4337382/',\n  },\n\n  'gallagher-bodyfat-2000': {\n    abnt: 'GALLAGHER, D. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. American Journal of Clinical Nutrition, v. 72, n. 3, p. 694-701, 2000.',\n    key: 'gallagher-bodyfat-2000',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10966886/',\n  },\n\n  'ge-corescan': {\n    abnt: 'GE HEALTHCARE. enCORE Software CoreScan: Visceral Adipose Tissue (VAT) assessment. Madison: GE Medical Systems Lunar, [s. d.]. (Documentação do fabricante do DEXA Lunar Prodigy; classificação Healthy 0–52 in³, Increased Risk 52,15–112,10 in³, At Risk 112,10+ in³, equivalente a 0–852 cm³, 854–1.837 cm³, 1.837+ cm³.)',\n    key: 'ge-corescan',\n    url: 'https://www.gehealthcare.com/products/bone-and-metabolic-health/encore',\n  },\n\n  'geloneze-brams-2009': {\n    abnt: 'GELONEZE, B. et al. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome — Brazilian Metabolic Syndrome Study (BRAMS). Arquivos Brasileiros de Endocrinologia & Metabologia, v. 53, n. 2, p. 281-287, 2009.',\n    doi: '10.1590/S0004-27302009000200020',\n    key: 'geloneze-brams-2009',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19466221/',\n  },\n\n  'george-ck-2016': {\n    abnt: 'GEORGE, M. D.; MCGILL, N. K.; BAKER, J. F. Creatine kinase in the U.S. population: impact of demographics, comorbidities, and body composition on the normal range. Medicine, v. 95, n. 33, e4344, 2016.',\n    doi: '10.1097/MD.0000000000004344',\n    key: 'george-ck-2016',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/27537560/',\n  },\n\n  'giannitsis-hstnt-2010': {\n    abnt: 'GIANNITSIS, E. et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clinical Chemistry, v. 56, n. 2, p. 254-261, 2010.',\n    doi: '10.1373/clinchem.2009.132654',\n    key: 'giannitsis-hstnt-2010',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19959623/',\n  },\n\n  'glis-2024': {\n    abnt: 'KIRK, B. et al. The conceptual definition of sarcopenia: Delphi consensus from the Global Leadership Initiative in Sarcopenia (GLIS). Age and Ageing, v. 53, n. 3, afae052, 2024.',\n    doi: '10.1093/ageing/afae052',\n    key: 'glis-2024',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/38520141/',\n  },\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Ácidos graxos ômega\n  // ---------------------------------------------------------------------------\n  'harris-omega3-2004': {\n    abnt: 'HARRIS, W. S.; VON SCHACKY, C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine, v. 39, n. 1, p. 212-220, 2004.',\n    doi: '10.1016/j.ypmed.2004.02.030',\n    key: 'harris-omega3-2004',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/15208005/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Referência laboratorial geral\n  // ---------------------------------------------------------------------------\n  'kalaria-ck-ri-2026': {\n    abnt: 'KALARIA, T. et al. Age, sex and ethnicity changes in creatine kinase and sex- and ethnicity-specific reference intervals of creatine kinase. Clinical Medicine, v. 26, n. 4, p. 100596, 2026.',\n    doi: '10.1016/j.clinme.2026.100596',\n    key: 'kalaria-ck-ri-2026',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/42142664/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Nefrologia\n  // ---------------------------------------------------------------------------\n  'kdigo-ckd-2024': {\n    abnt: 'KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International, v. 105, n. 4S, p. S117-S314, 2024.',\n    doi: '10.1016/j.kint.2023.10.018',\n    key: 'kdigo-ckd-2024',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/38490803/',\n  },\n\n  'keller-tni-2013': {\n    abnt: 'KELLER, T. et al. Defining a reference population to determine the 99th percentile of a contemporary sensitive cardiac troponin I assay. International Journal of Cardiology, v. 167, n. 4, p. 1423-1429, 2013.',\n    doi: '10.1016/j.ijcard.2012.04.063',\n    key: 'keller-tni-2013',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/22560907/',\n  },\n\n  'kelly-dxa-2009': {\n    abnt: 'KELLY, T. L. et al. Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS One, v. 4, n. 9, e7038, 2009.',\n    doi: '10.1371/journal.pone.0007038',\n    key: 'kelly-dxa-2009',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19753111/',\n  },\n\n  'khetarpal-apociii-2016': {\n    abnt: 'KHETARPAL, S. A. et al. Why is apolipoprotein CIII emerging as a novel therapeutic target to reduce the burden of cardiovascular disease? Current Atherosclerosis Reports, v. 18, n. 10, p. 59, 2016.',\n    key: 'khetarpal-apociii-2016',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC5018018/',\n  },\n\n  'klee-bhb-2020': {\n    abnt: 'KLEE, P. et al. Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples. Practical Laboratory Medicine, v. 18, e00146, 2020.',\n    doi: '10.1016/j.plabm.2019.e00146',\n    key: 'klee-bhb-2020',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC6999181/',\n  },\n\n  'maisel-bnp-2002': {\n    abnt: 'MAISEL, A. S. et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. New England Journal of Medicine, v. 347, n. 3, p. 161-167, 2002.',\n    doi: '10.1056/NEJMoa020233',\n    key: 'maisel-bnp-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12124404/',\n  },\n\n  'meuwese-mpo-2007': {\n    abnt: 'MEUWESE, M. C. et al. Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study. Journal of the American College of Cardiology, v. 50, n. 2, p. 159-165, 2007.',\n    doi: '10.1016/j.jacc.2007.03.033',\n    key: 'meuwese-mpo-2007',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/17616301/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Marcadores metabólicos e inflamatórios\n  // ---------------------------------------------------------------------------\n  'nemeth-adma-2017': {\n    abnt: 'NEMETH, B. et al. The issue of plasma asymmetric dimethylarginine reference range: a systematic review and meta-analysis. PLoS One, v. 12, n. 5, e0177493, 2017.',\n    doi: '10.1371/journal.pone.0177493',\n    key: 'nemeth-adma-2017',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/28494019/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes brasileiras — Metais pesados (NR-7)\n  // ---------------------------------------------------------------------------\n  'nr7-pcmso-2020': {\n    abnt: 'BRASIL. Ministério do Trabalho e Emprego. NR-7 — PCMSO, Quadro 1: Indicadores biológicos. Portaria n. 6.734, de 9 de março de 2020. Diário Oficial da União, Brasília, 13 mar. 2020.',\n    key: 'nr7-pcmso-2020',\n    url: 'https://www.gov.br/trabalho-e-emprego/pt-br/assuntos/inspecao-do-trabalho/seguranca-e-saude-no-trabalho/sst-portarias/2022/portaria-no-567-de-10-de-marco-de-2022-alteracoes-na-nr-7.pdf',\n  },\n\n  'ofenheimer-vat-2020': {\n    abnt: 'OFENHEIMER, A. et al. Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18-81 years: results from the LEAD cohort. European Journal of Clinical Nutrition, v. 74, p. 1181-1191, 2020.',\n    doi: '10.1038/s41430-020-0596-5',\n    key: 'ofenheimer-vat-2020',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/32123345/',\n  },\n\n  'pns-bioquimica-2019': {\n    abnt: 'SZWARCWALD, C. L. et al. Valores de referência para exames laboratoriais de colesterol, hemoglobina glicosilada e creatinina da população adulta brasileira. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190002.supl.2, 2019.',\n    doi: '10.1590/1980-549720190002.supl.2',\n    key: 'pns-bioquimica-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596373/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Pesquisa Nacional de Saúde (PNS) — Intervalos de referência brasileiros\n  // ---------------------------------------------------------------------------\n  'pns-hemograma-2019': {\n    abnt: 'ROSENFELD, L. G. et al. Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190003.supl.2, 2019.',\n    doi: '10.1590/1980-549720190003.supl.2',\n    key: 'pns-hemograma-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596374/',\n  },\n\n  'pns-renal-2019': {\n    abnt: 'MALTA, D. C. et al. Evaluation of renal function in the Brazilian adult population, according to laboratory criteria from the National Health Survey. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190010.supl.2, 2019.',\n    doi: '10.1590/1980-549720190010.supl.2',\n    key: 'pns-renal-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596381/',\n  },\n\n  'rumberger-cac-1999': {\n    abnt: 'RUMBERGER, J. A. et al. Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clinic Proceedings, v. 74, n. 3, p. 243-252, 1999.',\n    doi: '10.4065/74.3.243',\n    key: 'rumberger-cac-1999',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10089993/',\n  },\n\n  'sbc-ic-2018': {\n    abnt: 'ROHDE, L. E. P. et al. Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda. Arquivos Brasileiros de Cardiologia, São Paulo, v. 111, n. 3, p. 436-539, set. 2018.',\n    doi: '10.5935/abc.20180190',\n    key: 'sbc-ic-2018',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/30379264/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Cardiologia\n  // ---------------------------------------------------------------------------\n  'sbc-lipids-2017': {\n    abnt: 'FALUDI, A. A. et al. Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2017. Arquivos Brasileiros de Cardiologia, São Paulo, v. 109, n. 2, supl. 1, p. 1-76, ago. 2017.',\n    doi: '10.5935/abc.20170121',\n    key: 'sbc-lipids-2017',\n    url: 'https://www.scielo.br/j/abc/a/whBsCyzTDzGYJcsBY7YVkWn/?lang=pt',\n  },\n\n  'sbc-lipids-2025': {\n    abnt: 'RACHED, F. H. et al. Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2025. Arquivos Brasileiros de Cardiologia, São Paulo, v. 122, n. 9, e20250640, out. 2025.',\n    doi: '10.36660/abc.20250640',\n    key: 'sbc-lipids-2025',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC12674852/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Diabetes\n  // ---------------------------------------------------------------------------\n  'sbd-diabetes-2024': {\n    // Chave mantida como 'sbd-diabetes-2024' para compatibilidade com\n    // consumidores publicados; a diretriz correspondente é o documento vivo\n    // de diretriz.diabetes.org.br, cuja edição citada quando este registro foi\n    // atualizado é \"Edição 2025\". Semelhante ao caso de sbpc-ml-2021 abaixo.\n    abnt: 'SOCIEDADE BRASILEIRA DE DIABETES (SBD). Diretriz da Sociedade Brasileira de Diabetes — Edição 2025. São Paulo: SBD, 2025.',\n    doi: '10.29327/5660187',\n    isbn: '978-65-272-1932-3',\n    key: 'sbd-diabetes-2024',\n    url: 'https://diretriz.diabetes.org.br',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Endocrinologia e Metabologia\n  // ---------------------------------------------------------------------------\n  'sbem-thyroid-2013': {\n    abnt: 'SGARBI, J. A. et al. Consenso brasileiro para a abordagem clínica e tratamento do hipotireoidismo subclínico em adultos. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 57, n. 3, p. 166-183, 2013.',\n    doi: '10.1590/S0004-27302013000300003',\n    key: 'sbem-thyroid-2013',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/23681263/',\n  },\n  'sbem-vitamind-2014': {\n    abnt: 'MAEDA, S. S. et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 58, n. 5, p. 411-433, 2014.',\n    doi: '10.1590/0004-2730000003388',\n    key: 'sbem-vitamind-2014',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/25166032/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Patologia Clínica / Medicina Laboratorial\n  // ---------------------------------------------------------------------------\n  'sbpc-ml-2021': {\n    // Chave mantida como 'sbpc-ml-2021' para compatibilidade com consumidores;\n    // a edição autoritativa é de 2020 (verificada na Biblioteca Digital SBPC/ML\n    // em 2026-04-18). Ano na citação ABNT reflete a edição real.\n    abnt: 'SOCIEDADE BRASILEIRA DE PATOLOGIA CLÍNICA/MEDICINA LABORATORIAL (SBPC/ML). Recomendações da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML): Boas Práticas em Laboratório Clínico. São Paulo: SBPC/ML, 2020.',\n    key: 'sbpc-ml-2021',\n    url: 'https://bibliotecasbpc.org.br/index.php?P=4&C=0.2.443',\n  },\n\n  'schumann-ifcc-ldh-2002': {\n    abnt: 'SCHUMANN, G.; KLAUKE, R. New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects. Clinica Chimica Acta, v. 327, n. 1-2, p. 69-79, 2003.',\n    doi: '10.1016/S0009-8981(02)00341-8',\n    key: 'schumann-ifcc-ldh-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12482620/',\n  },\n\n  'schwedhelm-sdma-2011': {\n    abnt: 'SCHWEDHELM, E. et al. Plasma symmetric dimethylarginine reference limits from the Framingham Offspring Cohort. Clinical Chemistry and Laboratory Medicine, v. 49, n. 11, p. 1907-1910, 2011.',\n    doi: '10.1515/CCLM.2011.679',\n    key: 'schwedhelm-sdma-2011',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/21864208/',\n  },\n\n  'selhub-homocysteine-1999': {\n    abnt: 'SELHUB, J. et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Annals of Internal Medicine, v. 131, n. 5, p. 331-339, 1999.',\n    doi: '10.7326/0003-4819-131-5-199909070-00003',\n    key: 'selhub-homocysteine-1999',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10475885/',\n  },\n\n  'simopoulos-omega-ratio-2002': {\n    abnt: 'SIMOPOULOS, A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, v. 56, n. 8, p. 365-379, 2002.',\n    doi: '10.1016/S0753-3322(02)00253-6',\n    key: 'simopoulos-omega-ratio-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12442909/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Marcadores tumorais\n  // ---------------------------------------------------------------------------\n  'sturgeon-nacb-2008': {\n    abnt: 'STURGEON, C. M. et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clinical Chemistry, v. 54, n. 12, p. e11-e79, 2008.',\n    doi: '10.1373/clinchem.2008.105601',\n    key: 'sturgeon-nacb-2008',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19042984/',\n  },\n\n  'tietz-7ed-2015': {\n    abnt: 'BURTIS, C. A.; BRUNS, D. E. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. 7. ed. St. Louis: Elsevier Saunders, 2015.',\n    isbn: '978-1-4557-4165-6',\n    key: 'tietz-7ed-2015',\n  },\n\n  'torrissen-omega3-dbs-2025': {\n    abnt: 'TORRISSEN, M. et al. Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples. Lipids in Health and Disease, v. 24, n. 1, p. 260, 2025.',\n    doi: '10.1186/s12944-025-02676-6',\n    key: 'torrissen-omega3-dbs-2025',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/40783537/',\n  },\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Coagulação\n  // ---------------------------------------------------------------------------\n  'wells-ddimer-2003': {\n    abnt: 'WELLS, P. S. et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. New England Journal of Medicine, v. 349, p. 1227-1235, 2003.',\n    doi: '10.1056/NEJMoa023153',\n    key: 'wells-ddimer-2003',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/14507948/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — OMS\n  // ---------------------------------------------------------------------------\n  'who-iron-2020': {\n    abnt: 'WORLD HEALTH ORGANIZATION. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: WHO, 2020.',\n    isbn: '978-92-4-000012-4',\n    key: 'who-iron-2020',\n    url: 'https://www.who.int/publications/i/item/9789240000124',\n  },\n\n  'who-obesity-2000': {\n    abnt: 'WORLD HEALTH ORGANIZATION. Obesity: preventing and managing the global epidemic. WHO Technical Report Series, n. 894. Geneva: WHO, 2000.',\n    isbn: '92-4-120894-5',\n    key: 'who-obesity-2000',\n  },\n\n  'who-osteoporosis-1994': {\n    abnt: 'WHO STUDY GROUP. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series, n. 843. Geneva: WHO, 1994.',\n    key: 'who-osteoporosis-1994',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/7941614/',\n  },\n};\n\n/**\n * Extrai a chave de fonte de um valor `source` que pode conter localizador.\n *\n * @example\n * extractSourceKey('sbc-lipids-2017:p15') // 'sbc-lipids-2017'\n * extractSourceKey('sbpc-ml-2021')        // 'sbpc-ml-2021'\n */\nexport function extractSourceKey(source: string): string {\n  return source.split(':')[0] ?? source;\n}\n"],"mappings":";AAgCO,IAAM,kBAAmD;AAAA;AAAA;AAAA;AAAA,EAI9D,iBAAiB;AAAA,IACf,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,yBAAyB;AAAA,IACvB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,uBAAuB;AAAA,IACrB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,8BAA8B;AAAA,IAC5B,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,gBAAgB;AAAA,IACd,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,mBAAmB;AAAA,IACjB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,0BAA0B;AAAA,IACxB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,eAAe;AAAA,IACb,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,uBAAuB;AAAA,IACrB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,kBAAkB;AAAA,IAChB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,yBAAyB;AAAA,IACvB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,aAAa;AAAA,IACX,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAIA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,kBAAkB;AAAA,IAChB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,mBAAmB;AAAA,IACjB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,kBAAkB;AAAA,IAChB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,0BAA0B;AAAA,IACxB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,iBAAiB;AAAA,IACf,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,mBAAmB;AAAA,IACjB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,oBAAoB;AAAA,IAClB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,oBAAoB;AAAA,IAClB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,kBAAkB;AAAA,IAChB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,uBAAuB;AAAA,IACrB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,uBAAuB;AAAA,IACrB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,kBAAkB;AAAA,IAChB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,eAAe;AAAA,IACb,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,mBAAmB;AAAA,IACjB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,mBAAmB;AAAA,IACjB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,qBAAqB;AAAA;AAAA;AAAA;AAAA;AAAA,IAKnB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,qBAAqB;AAAA,IACnB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EACA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,gBAAgB;AAAA;AAAA;AAAA;AAAA,IAId,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,0BAA0B;AAAA,IACxB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,wBAAwB;AAAA,IACtB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,4BAA4B;AAAA,IAC1B,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,+BAA+B;AAAA,IAC7B,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,sBAAsB;AAAA,IACpB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,kBAAkB;AAAA,IAChB,MAAM;AAAA,IACN,MAAM;AAAA,IACN,KAAK;AAAA,EACP;AAAA,EAEA,6BAA6B;AAAA,IAC3B,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAIA,qBAAqB;AAAA,IACnB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA;AAAA;AAAA;AAAA,EAKA,iBAAiB;AAAA,IACf,MAAM;AAAA,IACN,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AAAA,EAEA,oBAAoB;AAAA,IAClB,MAAM;AAAA,IACN,MAAM;AAAA,IACN,KAAK;AAAA,EACP;AAAA,EAEA,yBAAyB;AAAA,IACvB,MAAM;AAAA,IACN,KAAK;AAAA,IACL,KAAK;AAAA,EACP;AACF;AASO,SAAS,iBAAiB,QAAwB;AACvD,SAAO,OAAO,MAAM,GAAG,EAAE,CAAC,KAAK;AACjC;","names":[]}

package/dist/{chunk-MNUQ57JR.js → chunk-KS2YZBAS.js}

@@ -2,13 +2,13 @@ import {
   BIOMARKER_CODE_SYSTEM,
   LOINC_SYSTEM
 } from "./chunk-A6HR4XDK.js";
-import {
-  codeToLoinc
-} from "./chunk-WDDW2WCY.js";
 import {
   getDefaultUnit,
-  unitToUCUM
-} from "./chunk-3XIMPALK.js";
+  resolveUcum
+} from "./chunk-Q3H5C6UR.js";
+import {
+  codeToLoinc
+} from "./chunk-4FKZG5GZ.js";
 
 // src/bundle-urls.ts
 var BUNDLE_BASE_URL = "https://precisa-saude.com.br/fhir";
@@ -45,13 +45,7 @@ var SEX_CODING = {
   },
   male: { code: "male", display: "Male", system: "http://hl7.org/fhir/administrative-gender" }
 };
-var buildReferenceRanges = (observation, sourceUnit, ucumUnit) => {
-  const quantity = (value) => ({
-    code: ucumUnit,
-    system: "http://unitsofmeasure.org",
-    unit: sourceUnit,
-    value
-  });
+var buildReferenceRanges = (observation, quantity) => {
   const toRanges = (low, high, sex) => {
     if (low === void 0 && high === void 0) return [];
     return [
@@ -70,7 +64,12 @@ var buildReferenceRanges = (observation, sourceUnit, ucumUnit) => {
 function labObservationToFHIR(observation, patientId, laboratoryName) {
   const loincCode = codeToLoinc(observation.biomarkerCode);
   const sourceUnit = observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;
-  const ucumUnit = unitToUCUM(sourceUnit);
+  const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);
+  const quantity = (value) => ({
+    ...ucumUnit ? { code: ucumUnit, system: "http://unitsofmeasure.org" } : {},
+    ...sourceUnit ? { unit: sourceUnit } : {},
+    value
+  });
   const isQualitative = observation.isQualitative || typeof observation.value === "string";
   const fhirObs = {
     category: [
@@ -129,13 +128,8 @@ function labObservationToFHIR(observation, patientId, laboratoryName) {
   if (isQualitative) {
     fhirObs.valueString = String(observation.value);
   } else {
-    fhirObs.valueQuantity = {
-      code: ucumUnit,
-      system: "http://unitsofmeasure.org",
-      unit: sourceUnit,
-      value: observation.value
-    };
-    const referenceRange = buildReferenceRanges(observation, sourceUnit, ucumUnit);
+    fhirObs.valueQuantity = quantity(observation.value);
+    const referenceRange = buildReferenceRanges(observation, quantity);
     if (referenceRange.length > 0) fhirObs.referenceRange = referenceRange;
   }
   return fhirObs;
@@ -271,4 +265,4 @@ export {
   userProfileToFHIR,
   labResultToFHIRBundle
 };
-//# sourceMappingURL=chunk-MNUQ57JR.js.map
+//# sourceMappingURL=chunk-KS2YZBAS.js.map

package/dist/chunk-KS2YZBAS.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/bundle-urls.ts","../src/converter.ts"],"sourcesContent":["/**\n * Endereço das entradas de um Bundle.\n *\n * O `fullUrl` identifica a entrada, e é contra ele que o validador resolve as\n * referências entre os recursos. Um Bundle com `subject.reference` valendo\n * `Patient/abc` só resolve se alguma entrada tiver `fullUrl` terminando em\n * `/Patient/abc`: a referência relativa é lida contra a base do `fullUrl` da\n * entrada, que é como os exemplos da própria HL7 montam Bundle de coleção.\n *\n * Antes o `fullUrl` era `urn:uuid:observation-<laudo>-<código>`, que erra duas\n * vezes. `urn:uuid:` exige a sintaxe de UUID e aquilo não era um UUID, e num\n * Bundle de entradas `urn:uuid:` a referência precisa repetir a URN inteira,\n * então nenhuma das relativas resolvia. Um laudo de 22 marcadores saía com 24\n * erros de URN e 22 referências perdidas.\n */\n/**\n * Recurso que já tem id, e por isso pode ser endereçado numa entrada.\n *\n * No FHIR o `id` é opcional, porque um recurso pode viajar sem identidade\n * própria. Numa entrada de Bundle ele não pode: sem id não há `fullUrl`, e sem\n * `fullUrl` nenhuma referência chega ao recurso. Os conversores daqui sempre\n * atribuem um, e o tipo passa a dizer isso em vez de deixar `undefined` chegar\n * até a montagem da URL.\n */\nexport type Addressable<T> = T & { id: string };\n\n/**\n * Base dos `fullUrl`.\n *\n * Não precisa responder a uma requisição: no FHIR o `fullUrl` é identidade, não\n * endereço de download. Fica sob um domínio nosso para não colidir com a\n * identidade de recurso de outra instituição, que é o risco real de usar\n * `example.org` em dado que sai da máquina.\n */\nexport const BUNDLE_BASE_URL = 'https://precisa-saude.com.br/fhir';\n\n/**\n * Monta o `fullUrl` a partir do próprio recurso.\n *\n * Recebe o recurso em vez do tipo e do id soltos de propósito. O defeito que\n * isto substitui nasceu de montar os dois lados em separado: o `fullUrl` dizia\n * `observation-demo-Hgb` enquanto o recurso tinha id `demo-Hgb`, e ninguém\n * percebeu porque nada obrigava os dois a concordarem.\n *\n * O parâmetro pede o mínimo que a URL consome, e não a união de recursos que\n * este pacote converte. Um Bundle pode carregar qualquer recurso do R4, e quem\n * acrescenta uma entrada de um tipo que não está nessa união (um `Specimen`,\n * por exemplo) precisa do mesmo endereço, senão monta o dele e as duas formas\n * divergem outra vez.\n */\nexport const entryFullUrl = (resource: Addressable<{ resourceType: string }>): string =>\n  `${BUNDLE_BASE_URL}/${resource.resourceType}/${resource.id}`;\n","/**\n * FHIR Converter\n *\n * Converts lab results to FHIR R4 DiagnosticReport and Observation resources.\n * See: https://hl7.org/fhir/diagnosticreport.html\n */\n\nimport { codeToLoinc } from './biomarkers';\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type {\n  FHIRBundle,\n  FHIRDiagnosticReport,\n  FHIRObservation,\n  FHIRPatient,\n  FHIRQuantity,\n  FHIRReferenceRange,\n} from './fhir-types';\nimport type { Flag, LabObservationData, LabReportData, UserProfileData } from './types';\nimport { getDefaultUnit, resolveUcum } from './units';\n\n// Re-export all types and functions\nexport * from './fhir-types';\n\n/**\n * Convert Flag to FHIR interpretation code\n */\nfunction interpretationCode(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'H'; // High\n    case 'L':\n      return 'L'; // Low\n    default:\n      return 'N'; // Normal\n  }\n}\n\n/**\n * Convert Flag to FHIR interpretation display\n */\nfunction interpretationDisplay(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'High';\n    case 'L':\n      return 'Low';\n    default:\n      return 'Normal';\n  }\n}\n\n/**\n * O `coding` do sexo, que vai **dentro** do CodeableConcept do `appliesTo`.\n *\n * O nome diz `CODING` e não `APPLIES_TO` de propósito: isto não é o valor do\n * campo, é uma entrada da lista de codificações dele. O embrulho acontece no\n * uso, em `{ coding: [SEX_CODING[sex]] }`.\n *\n * É o `AdministrativeGender`, e não o v3-ObservationInterpretation nem um\n * sistema nosso: um consumidor que já lê `Patient.gender` compara os dois sem\n * tabela de tradução no meio.\n */\nconst SEX_CODING = {\n  female: {\n    code: 'female',\n    display: 'Female',\n    system: 'http://hl7.org/fhir/administrative-gender',\n  },\n  male: { code: 'male', display: 'Male', system: 'http://hl7.org/fhir/administrative-gender' },\n} as const;\n\n/**\n * Monta as faixas de referência do `Observation`.\n *\n * Duas mudanças em relação ao que existia, e as duas são sobre não perder o que\n * o laudo imprimiu.\n *\n * **Um limite só já basta.** Antes a faixa só saía com os dois, e um laudo que\n * publica \"inferior a 190 mg/dL\" ou \"superior a 60 mL/min/1,73m²\" perdia o\n * campo inteiro. O R4 trata `low` e `high` como opcionais independentes e\n * documenta o caso de um lado só, e o importador deste mesmo pacote já lia\n * `low?.value` e `high?.value` com acesso opcional: a assimetria era só do\n * escritor. Ver PRE-430.\n *\n * **Mais de uma faixa, anotada.** Laudo com uma coluna de referência por sexo\n * passa a sair com as duas, cada uma com o seu `appliesTo`, em vez de o\n * pipeline escolher uma sem saber de quem é o exame. Ver PRE-424 e PRE-425.\n */\nconst buildReferenceRanges = (\n  observation: LabObservationData,\n  quantity: (value: number) => FHIRQuantity,\n): FHIRReferenceRange[] => {\n  // Devolve lista, e não uma faixa: o caso sem limite nenhum vira lista vazia\n  // em vez de `undefined`, e aí os dois caminhos abaixo se compõem com\n  // `flatMap` sem ninguém precisar filtrar nada depois.\n  const toRanges = (low?: number, high?: number, sex?: 'female' | 'male'): FHIRReferenceRange[] => {\n    if (low === undefined && high === undefined) return [];\n\n    return [\n      {\n        ...(sex === undefined ? {} : { appliesTo: [{ coding: [SEX_CODING[sex]] }] }),\n        ...(high === undefined ? {} : { high: quantity(high) }),\n        ...(low === undefined ? {} : { low: quantity(low) }),\n      },\n    ];\n  };\n\n  // A lista anotada tem precedência: quando ela existe, o par simples é o\n  // resumo de uma das colunas e repeti-lo publicaria a mesma faixa duas vezes,\n  // uma delas sem dizer a quem se aplica.\n  //\n  // Lista vazia cai no par simples, igual a ausente, e isso é escolha: as duas\n  // dizem \"não tenho faixa anotada\", e tratá-las diferente faria um `[]` vindo\n  // de um `.filter()` apagar em silêncio a faixa que o chamador também mandou\n  // em `referenceMin` e `referenceMax`.\n  if (observation.referenceRanges && observation.referenceRanges.length > 0) {\n    return observation.referenceRanges.flatMap((r) => toRanges(r.low, r.high, r.appliesTo));\n  }\n\n  return toRanges(observation.referenceMin, observation.referenceMax);\n};\n\n/**\n * Convert generic lab observation to FHIR Observation\n */\nexport function labObservationToFHIR(\n  observation: LabObservationData,\n  patientId: string,\n  laboratoryName?: string,\n): Addressable<FHIRObservation> {\n  const loincCode = codeToLoinc(observation.biomarkerCode);\n  // Use default unit if source unit is empty\n  const sourceUnit =\n    observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;\n  // `system` + `code` só saem quando a unidade resolve em UCUM. Unidade que o\n  // pacote não sabe traduzir fica só em `unit`, como texto: afirmar\n  // `http://unitsofmeasure.org` sobre `x10^3/mm3` era publicar um código\n  // falso, e quem consome o Bundle confiando no system trataria aquilo como\n  // UCUM de verdade.\n  const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);\n  const quantity = (value: number): FHIRQuantity => ({\n    ...(ucumUnit ? { code: ucumUnit, system: 'http://unitsofmeasure.org' } : {}),\n    ...(sourceUnit ? { unit: sourceUnit } : {}),\n    value,\n  });\n  const isQualitative = observation.isQualitative || typeof observation.value === 'string';\n\n  // Base observation structure\n  const fhirObs: Addressable<FHIRObservation> = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'laboratory',\n            display: 'Laboratory',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      // Sem LOINC, o coding LOINC simplesmente não sai. Antes ia `99999-9`,\n      // que não é código LOINC nenhum: publicava sob `http://loinc.org` uma\n      // afirmação falsa, e quem consumisse o bundle confiando no system\n      // trataria aquilo como código de verdade. Composição corporal, densidade\n      // óssea e escore de cálcio não têm LOINC, e o certo é a lacuna explícita.\n      coding: [\n        ...(loincCode\n          ? 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[{ system: 'phone' as const, value: profile.phone }] : []),\n      ].length > 0\n        ? [\n            ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n            ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n          ]\n        : undefined,\n  };\n}\n\n/**\n * Convert complete lab result to FHIR Bundle\n * This is the main function for exporting lab results to FHIR R4 format\n */\nexport function labResultToFHIRBundle(\n  report: LabReportData,\n  observations: LabObservationData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n\n  // Convert observations\n  const fhirObservations = observations.map((obs) => {\n    const resource = labObservationToFHIR(\n      { ...obs, collectionDate: report.collectionDate },\n      patientId,\n      report.laboratoryName,\n    );\n\n    return { fullUrl: entryFullUrl(resource), resource };\n  });\n\n  // Os ids vêm dos recursos já montados, e não de uma segunda montagem da mesma\n  // regra. 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package/dist/{chunk-555WKD6J.cjs → chunk-LXKFVJF4.cjs}

@@ -1,6 +1,6 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } } function _optionalChain(ops) { let lastAccessLHS = undefined; let value = ops[0]; let i = 1; while (i < ops.length) { const op = ops[i]; const fn = ops[i + 1]; i += 2; if ((op === 'optionalAccess' || op === 'optionalCall') && value == null) { return undefined; } if (op === 'access' || op === 'optionalAccess') { lastAccessLHS = value; value = fn(value); } else if (op === 'call' || op === 'optionalCall') { value = fn((...args) => value.call(lastAccessLHS, ...args)); lastAccessLHS = undefined; } } return value; }
 
-var _chunkAZTZYOAVcjs = require('./chunk-AZTZYOAV.cjs');
+var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
 
 // src/reference-ranges.ts
 var biomarkerRangeDefinitions = {
@@ -2013,7 +2013,7 @@ function applyFallbackReferenceRanges(biomarkers) {
     }
     const fallback = getFallbackReferenceRange(biomarker.code);
     if (fallback) {
-      const canonicalUnit = _chunkAZTZYOAVcjs.getCanonicalUnit.call(void 0, biomarker.code);
+      const canonicalUnit = _chunk5RC7C7HJcjs.getCanonicalUnit.call(void 0, biomarker.code);
       const unitsMatch = !biomarker.unit || biomarker.unit.toLowerCase() === fallback.unit.toLowerCase() || canonicalUnit && biomarker.unit.toLowerCase() === canonicalUnit.toLowerCase() || // Handle common unit variations
       biomarker.unit === "%" && fallback.unit === "%";
       if (unitsMatch) {
@@ -2038,4 +2038,4 @@ function applyFallbackReferenceRanges(biomarkers) {
 
 
 exports.biomarkerRangeDefinitions = biomarkerRangeDefinitions; exports.defaultReferenceRanges = defaultReferenceRanges; exports.getReferenceRange = getReferenceRange; exports.getRangeDirection = getRangeDirection; exports.getFallbackReferenceRange = getFallbackReferenceRange; exports.applyFallbackReferenceRanges = applyFallbackReferenceRanges;
-//# sourceMappingURL=chunk-555WKD6J.cjs.map
+//# sourceMappingURL=chunk-LXKFVJF4.cjs.map