@precisa-saude/fhir 0.31.2 → 0.31.3

package/dist/{chunk-XX7KTBUX.js → chunk-TV4NPK5N.js}

@@ -8,7 +8,7 @@ import {
   isValidCode,
   loincToCode,
   normalizeCode
-} from "./chunk-FSAQ3USO.js";
+} from "./chunk-L4KJ3QWU.js";
 import {
   validateFHIRImportBundle
 } from "./chunk-N3ZCOLG2.js";
@@ -162,4 +162,4 @@ export {
   mapFHIRObservationToInternal,
   processImportBundle
 };
-//# sourceMappingURL=chunk-XX7KTBUX.js.map
+//# sourceMappingURL=chunk-TV4NPK5N.js.map

package/dist/cli.js

@@ -2975,7 +2975,7 @@ var BIOMARKER_DEFINITIONS = [
       en: ["Troponin T", "cTnT", "Cardiac Troponin T", "hs-TnT", "High-Sensitivity Troponin T"],
       pt: ["Troponina T", "cTnT", "Troponina T Card\xEDaca", "Troponina T Ultrassens\xEDvel"]
     },
-    unit: "ng/mL"
+    unit: "ng/L"
   },
   // ============================================================================
   // COAGULATION — Coagulação
@@ -3705,17 +3705,20 @@ var BIOMARKER_UNITS = {
     siUcum: "umol/L",
     siUnit: "\xB5mol/L"
   },
+  // Imunoglobulinas: canônica em mg/dL, a unidade da faixa de referência
+  // (Tietz) e a que laboratórios brasileiros e americanos imprimem. g/L fica
+  // como unidade SI; a conversão é exata (g/L × 100 = mg/dL, em FIXED_FACTORS).
   IgA: {
     aliases: { "g/l": "g/L", "mg/dl": "mg/dL" },
-    canonicalUcum: "g/L",
-    canonicalUnit: "g/L",
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
     siUcum: "g/L",
     siUnit: "g/L"
   },
   IgG: {
     aliases: { "g/l": "g/L", "mg/dl": "mg/dL" },
-    canonicalUcum: "g/L",
-    canonicalUnit: "g/L",
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
     siUcum: "g/L",
     siUnit: "g/L"
   },
@@ -4030,8 +4033,20 @@ var BIOMARKER_UNITS = {
     siUcum: "ng/mL",
     siUnit: "ng/mL"
   },
+  // Troponina T: canônica em ng/L (hs-cTnT). O ensaio convencional imprime em
+  // ng/mL, que é a mesma grandeza que µg/L; converte por fator exato
+  // (ng/mL × 1000 = ng/L, em FIXED_FACTORS). pg/mL é a mesma unidade que ng/L
+  // e entra como alias, como em VitaminB12.
   TroponinT: {
-    aliases: { "ng/l": "ng/L" },
+    aliases: {
+      "mcg/l": "ng/mL",
+      "microg/l": "ng/mL",
+      "ng/l": "ng/L",
+      "ng/ml": "ng/mL",
+      "pg/ml": "ng/L",
+      "ug/l": "ng/mL",
+      "\xB5g/l": "ng/mL"
+    },
     canonicalUcum: "ng/L",
     canonicalUnit: "ng/L",
     siUcum: "ng/L",
@@ -5844,7 +5859,7 @@ var biomarkerRangeDefinitions = {
     source: "schwedhelm-sdma-2011"
   },
   Selenium: {
-    default: { max: 150, min: 70, optimalMax: 125, optimalMin: 85, unit: "mcg/L" },
+    default: { max: 150, min: 70, optimalMax: 125, optimalMin: 85, unit: "\xB5g/L" },
     source: "tietz-7ed-2015"
   },
   SHBG: {
@@ -6792,7 +6807,7 @@ async function main() {
     strict: false
   });
   if (values.version) {
-    process.stdout.write(`${"0.31.2"}
+    process.stdout.write(`${"0.31.3"}
 `);
     return;
   }

package/dist/converter.cjs

@@ -3,14 +3,14 @@
 
 
 
-var _chunkYX6B5YFJcjs = require('./chunk-YX6B5YFJ.cjs');
+var _chunkPS4LXHHOcjs = require('./chunk-PS4LXHHO.cjs');
 require('./chunk-OR67NJDZ.cjs');
-require('./chunk-3GN33H37.cjs');
-require('./chunk-MJ254F5K.cjs');
+require('./chunk-R5S7URXW.cjs');
+require('./chunk-AZTZYOAV.cjs');
 
 
 
 
 
-exports.labObservationToFHIR = _chunkYX6B5YFJcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkYX6B5YFJcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkYX6B5YFJcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkYX6B5YFJcjs.userProfileToFHIR;
+exports.labObservationToFHIR = _chunkPS4LXHHOcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkPS4LXHHOcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkPS4LXHHOcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkPS4LXHHOcjs.userProfileToFHIR;
 //# sourceMappingURL=converter.cjs.map

package/dist/converter.js

@@ -3,10 +3,10 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-WRDWLWU2.js";
+} from "./chunk-BXHJ3JAC.js";
 import "./chunk-A6HR4XDK.js";
-import "./chunk-FSAQ3USO.js";
-import "./chunk-R4MUCMO3.js";
+import "./chunk-L4KJ3QWU.js";
+import "./chunk-3XIMPALK.js";
 export {
   labObservationToFHIR,
   labReportToFHIR,

package/dist/importer.cjs

@@ -4,9 +4,9 @@
 
 
 
-var _chunkKL5SYSYZcjs = require('./chunk-KL5SYSYZ.cjs');
+var _chunkL7WLJNU5cjs = require('./chunk-L7WLJNU5.cjs');
 require('./chunk-OR67NJDZ.cjs');
-require('./chunk-3GN33H37.cjs');
+require('./chunk-R5S7URXW.cjs');
 require('./chunk-3ILBFLVQ.cjs');
 
 
@@ -14,5 +14,5 @@ require('./chunk-3ILBFLVQ.cjs');
 
 
 
-exports.MAX_FILE_SIZE = _chunkKL5SYSYZcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkKL5SYSYZcjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunkKL5SYSYZcjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunkKL5SYSYZcjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunkKL5SYSYZcjs.processImportBundle;
+exports.MAX_FILE_SIZE = _chunkL7WLJNU5cjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkL7WLJNU5cjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunkL7WLJNU5cjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunkL7WLJNU5cjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunkL7WLJNU5cjs.processImportBundle;
 //# sourceMappingURL=importer.cjs.map

package/dist/importer.js

@@ -4,9 +4,9 @@ import {
   extractObservationsFromBundle,
   mapFHIRObservationToInternal,
   processImportBundle
-} from "./chunk-XX7KTBUX.js";
+} from "./chunk-TV4NPK5N.js";
 import "./chunk-A6HR4XDK.js";
-import "./chunk-FSAQ3USO.js";
+import "./chunk-L4KJ3QWU.js";
 import "./chunk-N3ZCOLG2.js";
 export {
   MAX_FILE_SIZE,

package/dist/index.cjs

@@ -5,14 +5,14 @@
 
 
 
-var _chunkYX6B5YFJcjs = require('./chunk-YX6B5YFJ.cjs');
+var _chunkPS4LXHHOcjs = require('./chunk-PS4LXHHO.cjs');
 
 
 
 
 
 
-var _chunkKL5SYSYZcjs = require('./chunk-KL5SYSYZ.cjs');
+var _chunkL7WLJNU5cjs = require('./chunk-L7WLJNU5.cjs');
 
 
 
@@ -49,7 +49,7 @@ var _chunkOR67NJDZcjs = require('./chunk-OR67NJDZ.cjs');
 
 
 
-var _chunk3GN33H37cjs = require('./chunk-3GN33H37.cjs');
+var _chunkR5S7URXWcjs = require('./chunk-R5S7URXW.cjs');
 
 
 
@@ -57,7 +57,7 @@ var _chunk3GN33H37cjs = require('./chunk-3GN33H37.cjs');
 
 
 
-var _chunkEWX7VXN3cjs = require('./chunk-EWX7VXN3.cjs');
+var _chunk555WKD6Jcjs = require('./chunk-555WKD6J.cjs');
 
 
 
@@ -67,7 +67,7 @@ var _chunkEWX7VXN3cjs = require('./chunk-EWX7VXN3.cjs');
 
 
 
-var _chunkMJ254F5Kcjs = require('./chunk-MJ254F5K.cjs');
+var _chunkAZTZYOAVcjs = require('./chunk-AZTZYOAV.cjs');
 
 
 
@@ -234,14 +234,14 @@ function interventionToFHIRObservation(intervention, patientId) {
 }
 function interventionsToFHIRBundle(interventions, userProfile) {
   const patientId = userProfile.userId;
-  const fhirPatient = _chunkYX6B5YFJcjs.userProfileToFHIR.call(void 0, userProfile);
+  const fhirPatient = _chunkPS4LXHHOcjs.userProfileToFHIR.call(void 0, userProfile);
   const entries = interventions.map((intervention) => {
     const isMedication = intervention.type === "medication" || intervention.type === "supplement";
     const resource = isMedication ? interventionToFHIRMedicationStatement(intervention, patientId) : interventionToFHIRObservation(intervention, patientId);
-    return { fullUrl: _chunkYX6B5YFJcjs.entryFullUrl.call(void 0, resource), resource };
+    return { fullUrl: _chunkPS4LXHHOcjs.entryFullUrl.call(void 0, resource), resource };
   });
   return {
-    entry: [{ fullUrl: _chunkYX6B5YFJcjs.entryFullUrl.call(void 0, fhirPatient), resource: fhirPatient }, ...entries],
+    entry: [{ fullUrl: _chunkPS4LXHHOcjs.entryFullUrl.call(void 0, fhirPatient), resource: fhirPatient }, ...entries],
     resourceType: "Bundle",
     type: "collection"
   };
@@ -738,5 +738,5 @@ var specimenTypeCoding = (text) => BY_NORMALIZED_TEXT.get(normalize(text));
 
 
 
-exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_CODE_SYSTEM = _chunkOR67NJDZcjs.BIOMARKER_CODE_SYSTEM; exports.BIOMARKER_DEFAULT_UNIT = _chunkMJ254F5Kcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunk3GN33H37cjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkMJ254F5Kcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.BR_TIPO_AMOSTRA_VALUESET = BR_TIPO_AMOSTRA_VALUESET; exports.BUNDLE_BASE_URL = _chunkYX6B5YFJcjs.BUNDLE_BASE_URL; exports.CAC_INDICATOR_CODES = _chunk3GN33H37cjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunk3GN33H37cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunk3GN33H37cjs.DEXA_INDICATOR_CODES; exports.FHIR_BRASIL_EXTENSIONS = FHIR_BRASIL_EXTENSIONS; exports.HL7_SPECIMEN_TYPE_SYSTEM = HL7_SPECIMEN_TYPE_SYSTEM; exports.IG_CANONICAL = IG_CANONICAL; exports.LOINC_SYSTEM = _chunkOR67NJDZcjs.LOINC_SYSTEM; exports.MAX_FILE_SIZE = _chunkKL5SYSYZcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkKL5SYSYZcjs.MAX_OBSERVATIONS; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkMJ254F5Kcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkEWX7VXN3cjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkEWX7VXN3cjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunk3GN33H37cjs.codeToLoinc; exports.convertUnit = _chunkMJ254F5Kcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunkEWX7VXN3cjs.defaultReferenceRanges; exports.entryFullUrl = _chunkYX6B5YFJcjs.entryFullUrl; exports.extractObservationsFromBundle = _chunkKL5SYSYZcjs.extractObservationsFromBundle; exports.filterVisibleBiomarkers = _chunk3GN33H37cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunk3GN33H37cjs.findCodeByName; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunk3GN33H37cjs.generateCacFullReference; exports.generateDexaFullReference = _chunk3GN33H37cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunk3GN33H37cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunk3GN33H37cjs.generateLLMReference; exports.getAllCodes = _chunk3GN33H37cjs.getAllCodes; exports.getAllDefinitions = _chunk3GN33H37cjs.getAllDefinitions; exports.getAllLoincCodes = _chunk3GN33H37cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunk3GN33H37cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunk3GN33H37cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunk3GN33H37cjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkMJ254F5Kcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkMJ254F5Kcjs.getDefaultUnit; exports.getDefinitionByCode = _chunk3GN33H37cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunk3GN33H37cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunk3GN33H37cjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkEWX7VXN3cjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkEWX7VXN3cjs.getRangeDirection; exports.getReferenceRange = _chunkEWX7VXN3cjs.getReferenceRange; exports.getSIUnit = _chunkMJ254F5Kcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunk3GN33H37cjs.getSexForCode; exports.getVisibleDefinitions = _chunk3GN33H37cjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunk3GN33H37cjs.isBiomarkerVisible; exports.isCacDocument = _chunk3GN33H37cjs.isCacDocument; exports.isDexaDocument = _chunk3GN33H37cjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isValidCode = _chunk3GN33H37cjs.isValidCode; exports.isValidLoinc = _chunk3GN33H37cjs.isValidLoinc; exports.labObservationToFHIR = _chunkYX6B5YFJcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkYX6B5YFJcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkYX6B5YFJcjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunk3GN33H37cjs.loincToCode; exports.mapFHIRObservationToInternal = _chunkKL5SYSYZcjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunk3GN33H37cjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunkKL5SYSYZcjs.processImportBundle; exports.specimenTypeCoding = specimenTypeCoding; exports.toBiomarkerTests = _chunk3GN33H37cjs.toBiomarkerTests; exports.unitToUCUM = _chunkMJ254F5Kcjs.unitToUCUM; exports.userProfileToFHIR = _chunkYX6B5YFJcjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunk3ILBFLVQcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunk3ILBFLVQcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunk3ILBFLVQcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunk3GN33H37cjs.validateLoincNameMatch;
+exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_CODE_SYSTEM = _chunkOR67NJDZcjs.BIOMARKER_CODE_SYSTEM; exports.BIOMARKER_DEFAULT_UNIT = _chunkAZTZYOAVcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunkR5S7URXWcjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkAZTZYOAVcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.BR_TIPO_AMOSTRA_VALUESET = BR_TIPO_AMOSTRA_VALUESET; exports.BUNDLE_BASE_URL = _chunkPS4LXHHOcjs.BUNDLE_BASE_URL; exports.CAC_INDICATOR_CODES = _chunkR5S7URXWcjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunkR5S7URXWcjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkR5S7URXWcjs.DEXA_INDICATOR_CODES; exports.FHIR_BRASIL_EXTENSIONS = FHIR_BRASIL_EXTENSIONS; exports.HL7_SPECIMEN_TYPE_SYSTEM = HL7_SPECIMEN_TYPE_SYSTEM; exports.IG_CANONICAL = IG_CANONICAL; exports.LOINC_SYSTEM = _chunkOR67NJDZcjs.LOINC_SYSTEM; exports.MAX_FILE_SIZE = _chunkL7WLJNU5cjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkL7WLJNU5cjs.MAX_OBSERVATIONS; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkAZTZYOAVcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunk555WKD6Jcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunk555WKD6Jcjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunkR5S7URXWcjs.codeToLoinc; exports.convertUnit = _chunkAZTZYOAVcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunk555WKD6Jcjs.defaultReferenceRanges; exports.entryFullUrl = _chunkPS4LXHHOcjs.entryFullUrl; exports.extractObservationsFromBundle = _chunkL7WLJNU5cjs.extractObservationsFromBundle; exports.filterVisibleBiomarkers = _chunkR5S7URXWcjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkR5S7URXWcjs.findCodeByName; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunkR5S7URXWcjs.generateCacFullReference; exports.generateDexaFullReference = _chunkR5S7URXWcjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkR5S7URXWcjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkR5S7URXWcjs.generateLLMReference; exports.getAllCodes = _chunkR5S7URXWcjs.getAllCodes; exports.getAllDefinitions = _chunkR5S7URXWcjs.getAllDefinitions; exports.getAllLoincCodes = _chunkR5S7URXWcjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkR5S7URXWcjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkR5S7URXWcjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkR5S7URXWcjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkAZTZYOAVcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkAZTZYOAVcjs.getDefaultUnit; exports.getDefinitionByCode = _chunkR5S7URXWcjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkR5S7URXWcjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkR5S7URXWcjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunk555WKD6Jcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunk555WKD6Jcjs.getRangeDirection; exports.getReferenceRange = _chunk555WKD6Jcjs.getReferenceRange; exports.getSIUnit = _chunkAZTZYOAVcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunkR5S7URXWcjs.getSexForCode; exports.getVisibleDefinitions = _chunkR5S7URXWcjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunkR5S7URXWcjs.isBiomarkerVisible; exports.isCacDocument = _chunkR5S7URXWcjs.isCacDocument; exports.isDexaDocument = _chunkR5S7URXWcjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isValidCode = _chunkR5S7URXWcjs.isValidCode; exports.isValidLoinc = _chunkR5S7URXWcjs.isValidLoinc; exports.labObservationToFHIR = _chunkPS4LXHHOcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkPS4LXHHOcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkPS4LXHHOcjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunkR5S7URXWcjs.loincToCode; exports.mapFHIRObservationToInternal = _chunkL7WLJNU5cjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunkR5S7URXWcjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunkL7WLJNU5cjs.processImportBundle; exports.specimenTypeCoding = specimenTypeCoding; exports.toBiomarkerTests = _chunkR5S7URXWcjs.toBiomarkerTests; exports.unitToUCUM = _chunkAZTZYOAVcjs.unitToUCUM; exports.userProfileToFHIR = _chunkPS4LXHHOcjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunk3ILBFLVQcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunk3ILBFLVQcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunk3ILBFLVQcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunkR5S7URXWcjs.validateLoincNameMatch;
 //# sourceMappingURL=index.cjs.map

package/dist/index.js

@@ -5,14 +5,14 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-WRDWLWU2.js";
+} from "./chunk-BXHJ3JAC.js";
 import {
   MAX_FILE_SIZE,
   MAX_OBSERVATIONS,
   extractObservationsFromBundle,
   mapFHIRObservationToInternal,
   processImportBundle
-} from "./chunk-XX7KTBUX.js";
+} from "./chunk-TV4NPK5N.js";
 import {
   BIOMARKER_CODE_SYSTEM,
   LOINC_SYSTEM
@@ -49,7 +49,7 @@ import {
   normalizeCode,
   toBiomarkerTests,
   validateLoincNameMatch
-} from "./chunk-FSAQ3USO.js";
+} from "./chunk-L4KJ3QWU.js";
 import {
   applyFallbackReferenceRanges,
   biomarkerRangeDefinitions,
@@ -57,7 +57,7 @@ import {
   getFallbackReferenceRange,
   getRangeDirection,
   getReferenceRange
-} from "./chunk-CL2HNUGG.js";
+} from "./chunk-PLR54334.js";
 import {
   BIOMARKER_DEFAULT_UNIT,
   BIOMARKER_UNITS,
@@ -67,7 +67,7 @@ import {
   getDefaultUnit,
   getSIUnit,
   unitToUCUM
-} from "./chunk-R4MUCMO3.js";
+} from "./chunk-3XIMPALK.js";
 import {
   validateFHIRDiagnosticReport,
   validateFHIRImportBundle,

package/dist/reference-ranges.cjs

@@ -5,8 +5,8 @@
 
 
 
-var _chunkEWX7VXN3cjs = require('./chunk-EWX7VXN3.cjs');
-require('./chunk-MJ254F5K.cjs');
+var _chunk555WKD6Jcjs = require('./chunk-555WKD6J.cjs');
+require('./chunk-AZTZYOAV.cjs');
 
 
 
@@ -14,5 +14,5 @@ require('./chunk-MJ254F5K.cjs');
 
 
 
-exports.applyFallbackReferenceRanges = _chunkEWX7VXN3cjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkEWX7VXN3cjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunkEWX7VXN3cjs.defaultReferenceRanges; exports.getFallbackReferenceRange = _chunkEWX7VXN3cjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkEWX7VXN3cjs.getRangeDirection; exports.getReferenceRange = _chunkEWX7VXN3cjs.getReferenceRange;
+exports.applyFallbackReferenceRanges = _chunk555WKD6Jcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunk555WKD6Jcjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunk555WKD6Jcjs.defaultReferenceRanges; exports.getFallbackReferenceRange = _chunk555WKD6Jcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunk555WKD6Jcjs.getRangeDirection; exports.getReferenceRange = _chunk555WKD6Jcjs.getReferenceRange;
 //# sourceMappingURL=reference-ranges.cjs.map

package/dist/reference-ranges.js

@@ -5,8 +5,8 @@ import {
   getFallbackReferenceRange,
   getRangeDirection,
   getReferenceRange
-} from "./chunk-CL2HNUGG.js";
-import "./chunk-R4MUCMO3.js";
+} from "./chunk-PLR54334.js";
+import "./chunk-3XIMPALK.js";
 export {
   applyFallbackReferenceRanges,
   biomarkerRangeDefinitions,

package/dist/units.cjs

@@ -7,7 +7,7 @@
 
 
 
-var _chunkMJ254F5Kcjs = require('./chunk-MJ254F5K.cjs');
+var _chunkAZTZYOAVcjs = require('./chunk-AZTZYOAV.cjs');
 
 
 
@@ -17,5 +17,5 @@ var _chunkMJ254F5Kcjs = require('./chunk-MJ254F5K.cjs');
 
 
 
-exports.BIOMARKER_DEFAULT_UNIT = _chunkMJ254F5Kcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_UNITS = _chunkMJ254F5Kcjs.BIOMARKER_UNITS; exports.UNIT_TO_UCUM = _chunkMJ254F5Kcjs.UNIT_TO_UCUM; exports.convertUnit = _chunkMJ254F5Kcjs.convertUnit; exports.getCanonicalUnit = _chunkMJ254F5Kcjs.getCanonicalUnit; exports.getDefaultUnit = _chunkMJ254F5Kcjs.getDefaultUnit; exports.getSIUnit = _chunkMJ254F5Kcjs.getSIUnit; exports.unitToUCUM = _chunkMJ254F5Kcjs.unitToUCUM;
+exports.BIOMARKER_DEFAULT_UNIT = _chunkAZTZYOAVcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_UNITS = _chunkAZTZYOAVcjs.BIOMARKER_UNITS; exports.UNIT_TO_UCUM = _chunkAZTZYOAVcjs.UNIT_TO_UCUM; exports.convertUnit = _chunkAZTZYOAVcjs.convertUnit; exports.getCanonicalUnit = _chunkAZTZYOAVcjs.getCanonicalUnit; exports.getDefaultUnit = _chunkAZTZYOAVcjs.getDefaultUnit; exports.getSIUnit = _chunkAZTZYOAVcjs.getSIUnit; exports.unitToUCUM = _chunkAZTZYOAVcjs.unitToUCUM;
 //# sourceMappingURL=units.cjs.map

package/dist/units.js

@@ -7,7 +7,7 @@ import {
   getDefaultUnit,
   getSIUnit,
   unitToUCUM
-} from "./chunk-R4MUCMO3.js";
+} from "./chunk-3XIMPALK.js";
 export {
   BIOMARKER_DEFAULT_UNIT,
   BIOMARKER_UNITS,

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@precisa-saude/fhir",
-  "version": "0.31.2",
+  "version": "0.31.3",
   "description": "Tipos FHIR R4, definições de biomarcadores, faixas de referência e conversores para o ecossistema de saúde brasileiro",
   "keywords": [
     "fhir",

package/dist/chunk-MJ254F5K.cjs.map

@@ -1 +0,0 @@
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* Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Map units to UCUM (Unified Code for Units of Measure)\n * See: https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{ratio}': '{ratio}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  L: 'L',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  mL: 'mL',\n  'mmol/L': 'mmol/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  // Enzyme activity\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n};\n\n/**\n * Default units for biomarkers when source data doesn't provide one\n * These are the most common units used in Brazilian labs\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  // Proteins\n  Albumin: 'g/dL',\n  AlkalinePhosphatase: 'U/L',\n  // Liver\n  ALT: 'U/L',\n  AST: 'U/L',\n\n  Calcium: 'mg/dL',\n  Chloride: 'mEq/L',\n  // Lipids\n  Cholesterol: 'mg/dL',\n  // Kidney\n  Creatinine: 'mg/dL',\n  eAG: 'mg/dL',\n  Ferritin: 'ng/mL',\n\n  FolicAcid: 'ng/mL',\n  GGT: 'U/L',\n  // Glucose/Diabetes\n  Glucose: 'mg/dL',\n\n  HbA1c: '%',\n  Hct: '%',\n\n  HDL: 'mg/dL',\n  // Hematology\n  Hgb: 'g/dL',\n  Insulin: 'µUI/mL',\n\n  // Iron studies\n  Iron: 'µg/dL',\n  LDL: 'mg/dL',\n  Magnesium: 'mg/dL',\n  NonHDL_Cholesterol: 'mg/dL',\n\n  // Urinalysis - dimensionless\n  pH_Urine: '[pH]',\n  Potassium: 'mEq/L',\n  RDW: '%',\n  // Electrolytes\n  Sodium: 'mEq/L',\n  SpecificGravity_Urine: '{specific gravity}',\n\n  T3Free: 'pg/mL',\n  T4Free: 'ng/dL',\n  TIBC: 'µg/dL',\n  TotalProtein: 'g/dL',\n\n  TransferrinSaturation: '%',\n  Triglycerides: 'mg/dL',\n  // Thyroid\n  TSH: 'µUI/mL',\n\n  Urea: 'mg/dL',\n  UricAcid: 'mg/dL',\n\n  // Vitamins\n  VitaminB12: 'pg/mL',\n  VitaminD: 'ng/mL',\n  VLDL: 'mg/dL',\n};\n\n/**\n * Convert unit to UCUM format\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\n/** Percentage biomarkers — canonical and SI both use %. */\nconst PERCENTAGE_ALIASES: Record<string, string> = { '%': '%', pct: '%', percent: '%' };\nconst PERCENTAGE: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '%',\n  canonicalUnit: '%',\n  siUcum: '%',\n  siUnit: '%',\n};\n\n/** Enzyme activity — canonical and SI both use U/L. */\nconst ENZYME_ALIASES: Record<string, string> = { 'iu/l': 'U/L', 'u/l': 'U/L' };\nconst ENZYME: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'U/L',\n  canonicalUnit: 'U/L',\n  siUcum: 'U/L',\n  siUnit: 'U/L',\n};\n\n/** Monovalent electrolytes — mEq/L ↔ mmol/L (1:1). */\nconst ELECTROLYTE_MONO_ALIASES: Record<string, string> = { 'meq/l': 'mEq/L', 'mmol/l': 'mmol/L' };\nconst ELECTROLYTE_MONO: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'meq/L',\n  canonicalUnit: 'mEq/L',\n  siUcum: 'mmol/L',\n  siUnit: 'mmol/L',\n};\n\n/** CAC scores — Agatston Units (AU), dimensionless. */\nconst CAC_ALIASES: Record<string, string> = { au: 'AU' };\nconst CAC: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '{score}',\n  canonicalUnit: 'AU',\n  siUcum: '{score}',\n  siUnit: 'AU',\n};\n\n/** nmol/L biomarkers — same unit for canonical and SI. */\nconst NMOL_L_ALIASES: Record<string, string> = { 'nmol/l': 'nmol/L' };\nconst NMOL_L: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'nmol/L',\n  canonicalUnit: 'nmol/L',\n  siUcum: 'nmol/L',\n  siUnit: 'nmol/L',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  AFP: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  ALT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AMH: {\n    aliases: { 'ng/ml': 'ng/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 12_500,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AntiTPO: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AoA1: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },\n  ApoB: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AST: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BilirubinDirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinIndirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinTotal: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  BMI: {\n    aliases: { 'kg/m2': 'kg/m²', 'kg/m²': 'kg/m²' },\n    canonicalUcum: 'kg/m2',\n    canonicalUnit: 'kg/m²',\n    siUcum: 'kg/m2',\n    siUnit: 'kg/m²',\n  },\n  BNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  CA125: {\n    aliases: { 'u/ml': 'U/mL' },\n    canonicalUcum: 'U/mL',\n    canonicalUnit: 'U/mL',\n    siUcum: 'U/mL',\n    siUnit: 'U/mL',\n  },\n  CAC_LAD: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LCX: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LMA: { aliases: CAC_ALIASES, ...CAC },\n  CAC_RCA: { aliases: CAC_ALIASES, ...CAC },\n  Calcium: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 40.08,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CEA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CK: { aliases: ENZYME_ALIASES, ...ENZYME },\n  CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cortisol: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 362.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  DHEAS: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 368.49,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  DHT: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 290.44,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  ESR: {\n    aliases: { 'mm/h': 'mm/h', 'mm/hr': 'mm/h' },\n    canonicalUcum: 'mm/h',\n    canonicalUnit: 'mm/h',\n    siUcum: 'mm/h',\n    siUnit: 'mm/h',\n  },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  Folate: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 441.4,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  GGT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Globulin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Homocysteine: {\n    aliases: { 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'umol/L',\n    canonicalUnit: 'µmol/L',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  IgA: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'g/L',\n    canonicalUnit: 'g/L',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  IgG: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'g/L',\n    canonicalUnit: 'g/L',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  INR: {\n    aliases: { '{ratio}': '{ratio}' },\n    canonicalUcum: '{ratio}',\n    canonicalUnit: '{ratio}',\n    siUcum: '{ratio}',\n    siUnit: '{ratio}',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Lead: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 207.2,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leptin: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCH: {\n    aliases: { pg: 'pg' },\n    canonicalUcum: 'pg',\n    canonicalUnit: 'pg',\n    siUcum: 'pg',\n    siUnit: 'pg',\n  },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  MCV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Mercury: {\n    aliases: { 'mcg/l': 'µg/L', 'nmol/l': 'nmol/L', 'ug/l': 'µg/L', 'µg/l': 'µg/L' },\n    canonicalUcum: 'ug/L',\n    canonicalUnit: 'µg/L',\n    molecularWeight: 200.59,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Microalbumin_Urine: {\n    aliases: { 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MPV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Myeloperoxidase: {\n    aliases: { 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pmol/L',\n    canonicalUnit: 'pmol/L',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,\n  // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.\n  NonHDL_Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  NTproBNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Progesterone: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 314.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  ProthrombinTime: {\n    aliases: { s: 's', sec: 's' },\n    canonicalUcum: 's',\n    canonicalUnit: 's',\n    siUcum: 's',\n    siUnit: 's',\n  },\n  PSA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  PSA_Free: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  RheumatoidFactor: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  T3Free: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 650.98,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Free: {\n    aliases: { 'ng/dl': 'ng/dL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 776.87,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Total: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 776.87,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Testosterone: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 288.42,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  TotalProtein: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TroponinI: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  TroponinT: {\n    aliases: { 'ng/l': 'ng/L' },\n    canonicalUcum: 'ng/L',\n    canonicalUnit: 'ng/L',\n    siUcum: 'ng/L',\n    siUnit: 'ng/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'mIU/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  UricAcid: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 168.11,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  VLDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'g/L -> mg/dL': 100,\n  'mEq/L -> mmol/L': 1,\n  'mg/dL -> g/L': 0.01,\n  'mmol/L -> mEq/L': 1,\n  'ng/dL -> pg/mL': 10,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/dL -> pmol/L': { divideByMW: true, scale: 10_000 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'ng/mL -> pmol/L': { divideByMW: true, scale: 1_000_000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'nmol/L -> µg/dL': { divideByMW: false, scale: 10_000 },\n  'nmol/L -> µg/L': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> ng/dL': { divideByMW: false, scale: 10_000 },\n  'pmol/L -> ng/mL': { divideByMW: false, scale: 1_000_000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µg/dL -> nmol/L': { divideByMW: true, scale: 10_000 },\n  'µg/dL -> µmol/L': { divideByMW: true, scale: 10 },\n  'µg/L -> nmol/L': { divideByMW: true, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n  'µmol/L -> µg/dL': { divideByMW: false, scale: 10 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return null;\n}\n"]}