@precisa-saude/fhir 0.17.4 → 0.19.0

package/dist/biomarkers.cjs

@@ -30,7 +30,7 @@
 
 
 
-var _chunkONRVND6Ucjs = require('./chunk-ONRVND6U.cjs');
+var _chunkZ5VH5QGCcjs = require('./chunk-Z5VH5QGC.cjs');
 
 
 
@@ -63,5 +63,5 @@ var _chunkONRVND6Ucjs = require('./chunk-ONRVND6U.cjs');
 
 
 
-exports.BIOMARKER_DEFINITIONS = _chunkONRVND6Ucjs.BIOMARKER_DEFINITIONS; exports.CAC_INDICATOR_CODES = _chunkONRVND6Ucjs.CAC_INDICATOR_CODES; exports.DEXA_CATEGORIES = _chunkONRVND6Ucjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkONRVND6Ucjs.DEXA_INDICATOR_CODES; exports.codeToLoinc = _chunkONRVND6Ucjs.codeToLoinc; exports.filterVisibleBiomarkers = _chunkONRVND6Ucjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkONRVND6Ucjs.findCodeByName; exports.generateCacFullReference = _chunkONRVND6Ucjs.generateCacFullReference; exports.generateDexaFullReference = _chunkONRVND6Ucjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkONRVND6Ucjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkONRVND6Ucjs.generateLLMReference; exports.getAllCodes = _chunkONRVND6Ucjs.getAllCodes; exports.getAllDefinitions = _chunkONRVND6Ucjs.getAllDefinitions; exports.getAllLoincCodes = _chunkONRVND6Ucjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkONRVND6Ucjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkONRVND6Ucjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkONRVND6Ucjs.getBiomarkersForCategories; exports.getDefinitionByCode = _chunkONRVND6Ucjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkONRVND6Ucjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkONRVND6Ucjs.getDefinitionsBySex; exports.getSexForCode = _chunkONRVND6Ucjs.getSexForCode; exports.getVisibleDefinitions = _chunkONRVND6Ucjs.getVisibleDefinitions; exports.isBiomarkerVisible = _chunkONRVND6Ucjs.isBiomarkerVisible; exports.isCacDocument = _chunkONRVND6Ucjs.isCacDocument; exports.isDexaDocument = _chunkONRVND6Ucjs.isDexaDocument; exports.isValidCode = _chunkONRVND6Ucjs.isValidCode; exports.isValidLoinc = _chunkONRVND6Ucjs.isValidLoinc; exports.loincToCode = _chunkONRVND6Ucjs.loincToCode; exports.normalizeCode = _chunkONRVND6Ucjs.normalizeCode; exports.toBiomarkerTests = _chunkONRVND6Ucjs.toBiomarkerTests; exports.validateLoincNameMatch = _chunkONRVND6Ucjs.validateLoincNameMatch;
+exports.BIOMARKER_DEFINITIONS = _chunkZ5VH5QGCcjs.BIOMARKER_DEFINITIONS; exports.CAC_INDICATOR_CODES = _chunkZ5VH5QGCcjs.CAC_INDICATOR_CODES; exports.DEXA_CATEGORIES = _chunkZ5VH5QGCcjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkZ5VH5QGCcjs.DEXA_INDICATOR_CODES; exports.codeToLoinc = _chunkZ5VH5QGCcjs.codeToLoinc; exports.filterVisibleBiomarkers = _chunkZ5VH5QGCcjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkZ5VH5QGCcjs.findCodeByName; exports.generateCacFullReference = _chunkZ5VH5QGCcjs.generateCacFullReference; exports.generateDexaFullReference = _chunkZ5VH5QGCcjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkZ5VH5QGCcjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkZ5VH5QGCcjs.generateLLMReference; exports.getAllCodes = _chunkZ5VH5QGCcjs.getAllCodes; exports.getAllDefinitions = _chunkZ5VH5QGCcjs.getAllDefinitions; exports.getAllLoincCodes = _chunkZ5VH5QGCcjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkZ5VH5QGCcjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkZ5VH5QGCcjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkZ5VH5QGCcjs.getBiomarkersForCategories; exports.getDefinitionByCode = _chunkZ5VH5QGCcjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkZ5VH5QGCcjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkZ5VH5QGCcjs.getDefinitionsBySex; exports.getSexForCode = _chunkZ5VH5QGCcjs.getSexForCode; exports.getVisibleDefinitions = _chunkZ5VH5QGCcjs.getVisibleDefinitions; exports.isBiomarkerVisible = _chunkZ5VH5QGCcjs.isBiomarkerVisible; exports.isCacDocument = _chunkZ5VH5QGCcjs.isCacDocument; exports.isDexaDocument = _chunkZ5VH5QGCcjs.isDexaDocument; exports.isValidCode = _chunkZ5VH5QGCcjs.isValidCode; exports.isValidLoinc = _chunkZ5VH5QGCcjs.isValidLoinc; exports.loincToCode = _chunkZ5VH5QGCcjs.loincToCode; exports.normalizeCode = _chunkZ5VH5QGCcjs.normalizeCode; exports.toBiomarkerTests = _chunkZ5VH5QGCcjs.toBiomarkerTests; exports.validateLoincNameMatch = _chunkZ5VH5QGCcjs.validateLoincNameMatch;
 //# sourceMappingURL=biomarkers.cjs.map

package/dist/biomarkers.js

@@ -30,7 +30,7 @@ import {
   normalizeCode,
   toBiomarkerTests,
   validateLoincNameMatch
-} from "./chunk-7O6VUA2B.js";
+} from "./chunk-MTWOF55H.js";
 export {
   BIOMARKER_DEFINITIONS,
   CAC_INDICATOR_CODES,

package/dist/{chunk-R6FI2RNB.cjs → chunk-6HKQY6VO.cjs}

@@ -1,14 +1,14 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _optionalChain(ops) { let lastAccessLHS = undefined; let value = ops[0]; let i = 1; while (i < ops.length) { const op = ops[i]; const fn = ops[i + 1]; i += 2; if ((op === 'optionalAccess' || op === 'optionalCall') && value == null) { return undefined; } if (op === 'access' || op === 'optionalAccess') { lastAccessLHS = value; value = fn(value); } else if (op === 'call' || op === 'optionalCall') { value = fn((...args) => value.call(lastAccessLHS, ...args)); lastAccessLHS = undefined; } } return value; }
 
 
-var _chunkONRVND6Ucjs = require('./chunk-ONRVND6U.cjs');
+var _chunkZ5VH5QGCcjs = require('./chunk-Z5VH5QGC.cjs');
 
 
 var _chunk3ILBFLVQcjs = require('./chunk-3ILBFLVQ.cjs');
 
 // src/importer.ts
-var MAX_OBSERVATIONS = 1e3;
-var MAX_FILE_SIZE = 5 * 1024 * 1024;
+var MAX_OBSERVATIONS = 5e3;
+var MAX_FILE_SIZE = 15 * 1024 * 1024;
 function extractLoincCode(observation) {
   if (!_optionalChain([observation, 'access', _ => _.code, 'optionalAccess', _2 => _2.coding])) return void 0;
   const loincCoding = observation.code.coding.find((c) => c.system === "http://loinc.org");
@@ -51,7 +51,7 @@ function mapFHIRObservationToInternal(observation, index) {
       }
     };
   }
-  const internalCode = _chunkONRVND6Ucjs.loincToCode.call(void 0, loincCode);
+  const internalCode = _chunkZ5VH5QGCcjs.loincToCode.call(void 0, loincCode);
   if (!internalCode) {
     return {
       skipped: {
@@ -62,7 +62,7 @@ function mapFHIRObservationToInternal(observation, index) {
       }
     };
   }
-  const definition = _chunkONRVND6Ucjs.getDefinitionByLoinc.call(void 0, loincCode);
+  const definition = _chunkZ5VH5QGCcjs.getDefinitionByLoinc.call(void 0, loincCode);
   let value;
   let unit = "";
   let isQualitative = false;
@@ -150,4 +150,4 @@ function processImportBundle(data) {
 
 
 exports.MAX_OBSERVATIONS = MAX_OBSERVATIONS; exports.MAX_FILE_SIZE = MAX_FILE_SIZE; exports.extractObservationsFromBundle = extractObservationsFromBundle; exports.mapFHIRObservationToInternal = mapFHIRObservationToInternal; exports.processImportBundle = processImportBundle;
-//# sourceMappingURL=chunk-R6FI2RNB.cjs.map
+//# sourceMappingURL=chunk-6HKQY6VO.cjs.map

package/dist/chunk-6HKQY6VO.cjs.map

@@ -0,0 +1 @@
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Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Extract LOINC code from an Observation's code.coding array\n */\nfunction extractLoincCode(observation: FHIRObservation): string | undefined {\n  if (!observation.code?.coding) return undefined;\n  const loincCoding = observation.code.coding.find((c) => c.system === 'http://loinc.org');\n  return loincCoding?.code;\n}\n\n/**\n * Extract interpretation flag from Observation\n */\nfunction extractFlag(observation: FHIRObservation): 'H' | 'L' | '' {\n  const code = observation.interpretation?.[0]?.coding?.[0]?.code;\n  if (code === 'H' || code === 'HH') return 'H';\n  if (code === 'L' || code === 'LL') return 'L';\n  return '';\n}\n\n/**\n * Extract Observation resources from a FHIR Bundle\n */\nexport function extractObservationsFromBundle(bundle: FHIRBundle): {\n  observations: FHIRObservation[];\n  skipped: SkippedEntry[];\n} {\n  const observations: FHIRObservation[] = [];\n  const skipped: SkippedEntry[] = [];\n\n  for (let i = 0; i < bundle.entry.length; i++) {\n    const entry = bundle.entry[i]!;\n    if (!entry.resource) {\n      skipped.push({ index: i, reason: 'Entry has no resource' });\n      continue;\n    }\n\n    if (entry.resource.resourceType !== 'Observation') {\n      // Non-observation resources are silently skipped (Patient, DiagnosticReport, etc.)\n      continue;\n    }\n\n    if (observations.length >= MAX_OBSERVATIONS) {\n      skipped.push({ index: i, reason: `Maximum of ${MAX_OBSERVATIONS} observations exceeded` });\n      continue;\n    }\n\n    observations.push(entry.resource as FHIRObservation);\n  }\n\n  return { observations, skipped };\n}\n\n/**\n * Map a FHIR Observation to internal format using LOINC→biomarker code lookup\n */\nexport function mapFHIRObservationToInternal(\n  observation: FHIRObservation,\n  index: number,\n): { observation: ImportedObservation } | { skipped: SkippedEntry } {\n  const loincCode = extractLoincCode(observation);\n\n  if (!loincCode) {\n    return {\n      skipped: {\n        index,\n        reason: 'No LOINC code found in observation coding',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  const internalCode = loincToCode(loincCode);\n  if (!internalCode) {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: `Unknown LOINC code: ${loincCode}`,\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  const definition = getDefinitionByLoinc(loincCode);\n\n  // Extract value\n  let value: number | string;\n  let unit = '';\n  let isQualitative = false;\n\n  if (observation.valueQuantity?.value !== undefined) {\n    value = observation.valueQuantity.value;\n    unit = observation.valueQuantity.unit || observation.valueQuantity.code || '';\n  } else if (observation.valueString) {\n    value = observation.valueString;\n    isQualitative = true;\n  } else {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no value (valueQuantity or valueString)',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract collection date (effectiveDateTime or effectivePeriod.start)\n  const collectionDate = observation.effectiveDateTime || observation.effectivePeriod?.start || '';\n  if (!collectionDate) {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no effectiveDateTime or effectivePeriod.start',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract reference ranges\n  let referenceMin: number | undefined;\n  let referenceMax: number | undefined;\n  if (observation.referenceRange?.[0]) {\n    referenceMin = observation.referenceRange[0].low?.value;\n    referenceMax = observation.referenceRange[0].high?.value;\n  }\n\n  const imported: ImportedObservation = {\n    biomarkerCode: internalCode,\n    biomarkerName:\n      definition?.names.pt[0] || definition?.names.en[0] || observation.code.text || internalCode,\n    collectionDate,\n    flag: extractFlag(observation),\n    isQualitative,\n    loincCode,\n    referenceMax,\n    referenceMin,\n    unit: unit || definition?.unit || '',\n    value,\n  };\n\n  return { observation: imported };\n}\n\n/**\n * Process a complete FHIR Bundle for import\n */\nexport function processImportBundle(data: unknown): FHIRImportResult {\n  // Structural validation\n  const validationErrors = validateFHIRImportBundle(data);\n  if (validationErrors.length > 0) {\n    return {\n      errors: validationErrors,\n      imported: [],\n      skipped: [],\n      totalProcessed: 0,\n    };\n  }\n\n  const bundle = data as FHIRBundle;\n\n  // Extract observations\n  const { observations, skipped } = extractObservationsFromBundle(bundle);\n\n  // Map each observation to internal format\n  const imported: ImportedObservation[] = [];\n  const allSkipped: SkippedEntry[] = [...skipped];\n\n  for (let i = 0; i < observations.length; i++) {\n    const result = mapFHIRObservationToInternal(observations[i]!, i);\n\n    if ('observation' in result) {\n      imported.push(result.observation);\n    } else {\n      allSkipped.push(result.skipped);\n    }\n  }\n\n  return {\n    errors: [],\n    imported,\n    skipped: allSkipped,\n    totalProcessed: observations.length,\n  };\n}\n\nexport { MAX_FILE_SIZE, MAX_OBSERVATIONS };\n"]}

package/dist/{chunk-NAUVJPLC.js → chunk-EXG2IU2O.js}

@@ -1,14 +1,14 @@
 import {
   getDefinitionByLoinc,
   loincToCode
-} from "./chunk-7O6VUA2B.js";
+} from "./chunk-MTWOF55H.js";
 import {
   validateFHIRImportBundle
 } from "./chunk-N3ZCOLG2.js";
 
 // src/importer.ts
-var MAX_OBSERVATIONS = 1e3;
-var MAX_FILE_SIZE = 5 * 1024 * 1024;
+var MAX_OBSERVATIONS = 5e3;
+var MAX_FILE_SIZE = 15 * 1024 * 1024;
 function extractLoincCode(observation) {
   if (!observation.code?.coding) return void 0;
   const loincCoding = observation.code.coding.find((c) => c.system === "http://loinc.org");
@@ -150,4 +150,4 @@ export {
   mapFHIRObservationToInternal,
   processImportBundle
 };
-//# sourceMappingURL=chunk-NAUVJPLC.js.map
+//# sourceMappingURL=chunk-EXG2IU2O.js.map

package/dist/chunk-EXG2IU2O.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/importer.ts"],"sourcesContent":["/**\n * FHIR Importer\n *\n * Parses FHIR R4 Bundles and extracts Observation resources with known LOINC codes,\n * mapping them to internal biomarker codes for storage as lab results.\n */\n\nimport { getDefinitionByLoinc, loincToCode } from './biomarkers';\nimport type { FHIRBundle, FHIRObservation } from './fhir-types';\nimport { validateFHIRImportBundle } from './validators';\n\nexport interface ImportedObservation {\n  biomarkerCode: string;\n  biomarkerName: string;\n  collectionDate: string;\n  flag: 'H' | 'L' | '';\n  isQualitative: boolean;\n  loincCode: string;\n  referenceMax?: number;\n  referenceMin?: number;\n  unit: string;\n  value: number | string;\n}\n\nexport interface SkippedEntry {\n  index: number;\n  loincCode?: string;\n  reason: string;\n  resourceType?: string;\n}\n\nexport interface ImportError {\n  details: string;\n  field: string;\n}\n\nexport interface FHIRImportResult {\n  errors: ImportError[];\n  imported: ImportedObservation[];\n  skipped: SkippedEntry[];\n  totalProcessed: number;\n}\n\n/**\n * Limites de importação.\n *\n * Uma Observation exportada ocupa cerca de 1,25KB em JSON compacto e 2,75KB\n * quando o arquivo vem indentado, medido sobre um histórico real de 998\n * Observations em 61 laudos. Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Extract LOINC code from an Observation's code.coding array\n */\nfunction extractLoincCode(observation: FHIRObservation): string | undefined {\n  if (!observation.code?.coding) return undefined;\n  const loincCoding = observation.code.coding.find((c) => c.system === 'http://loinc.org');\n  return loincCoding?.code;\n}\n\n/**\n * Extract interpretation flag from Observation\n */\nfunction extractFlag(observation: FHIRObservation): 'H' | 'L' | '' {\n  const code = observation.interpretation?.[0]?.coding?.[0]?.code;\n  if (code === 'H' || code === 'HH') return 'H';\n  if (code === 'L' || code === 'LL') return 'L';\n  return '';\n}\n\n/**\n * Extract Observation resources from a FHIR Bundle\n */\nexport function extractObservationsFromBundle(bundle: FHIRBundle): {\n  observations: FHIRObservation[];\n  skipped: SkippedEntry[];\n} {\n  const observations: FHIRObservation[] = [];\n  const skipped: SkippedEntry[] = [];\n\n  for (let i = 0; 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package/dist/{chunk-NP4YZFUI.cjs → chunk-J3QVVVVH.cjs}

@@ -1,6 +1,6 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true});
 
-var _chunkONRVND6Ucjs = require('./chunk-ONRVND6U.cjs');
+var _chunkZ5VH5QGCcjs = require('./chunk-Z5VH5QGC.cjs');
 
 
 
@@ -30,7 +30,7 @@ function interpretationDisplay(flag) {
   }
 }
 function labObservationToFHIR(observation, patientId, laboratoryName) {
-  const loincCode = _chunkONRVND6Ucjs.codeToLoinc.call(void 0, observation.biomarkerCode) || "99999-9";
+  const loincCode = _chunkZ5VH5QGCcjs.codeToLoinc.call(void 0, observation.biomarkerCode) || "99999-9";
   const sourceUnit = observation.unit || _chunkMJ254F5Kcjs.getDefaultUnit.call(void 0, observation.biomarkerCode) || observation.unit;
   const ucumUnit = _chunkMJ254F5Kcjs.unitToUCUM.call(void 0, sourceUnit);
   const isQualitative = observation.isQualitative || typeof observation.value === "string";
@@ -248,4 +248,4 @@ function labResultToFHIRBundle(report, observations, userProfile) {
 
 
 exports.labObservationToFHIR = labObservationToFHIR; exports.labReportToFHIR = labReportToFHIR; exports.userProfileToFHIR = userProfileToFHIR; exports.labResultToFHIRBundle = labResultToFHIRBundle;
-//# sourceMappingURL=chunk-NP4YZFUI.cjs.map
+//# sourceMappingURL=chunk-J3QVVVVH.cjs.map

package/dist/{chunk-NP4YZFUI.cjs.map → chunk-J3QVVVVH.cjs.map}

@@ -1 +1 @@
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[{ system: 'phone' as const, value: profile.phone }] : []),\n      ].length > 0\n        ? [\n            ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n            ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n          ]\n        : undefined,\n  };\n}\n\n/**\n * Convert complete lab result to FHIR Bundle\n * This is the main function for exporting lab results to FHIR R4 format\n */\nexport function labResultToFHIRBundle(\n  report: LabReportData,\n  observations: LabObservationData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n\n  // Convert observations\n  const fhirObservations = observations.map((obs) => ({\n    fullUrl: `urn:uuid:observation-${obs.reportId}-${obs.biomarkerCode}`,\n    resource: labObservationToFHIR(\n      { ...obs, collectionDate: report.collectionDate },\n      patientId,\n      report.laboratoryName,\n    ),\n  }));\n\n  const observationIds = observations.map(\n    (obs) => `observation-${obs.reportId}-${obs.biomarkerCode}`,\n  );\n\n  // Convert report\n  const diagnosticReport = labReportToFHIR(report, patientId, observationIds);\n\n  // Convert patient\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  return {\n    entry: [\n      {\n        fullUrl: `urn:uuid:${patientId}`,\n        resource: fhirPatient,\n      },\n      {\n        fullUrl: `urn:uuid:diagnostic-report-${report.reportId}`,\n        resource: diagnosticReport,\n      },\n      ...fhirObservations,\n    ],\n    resourceType: 'Bundle',\n    type: 'collection',\n  };\n}\n"]}

package/dist/{chunk-LPYXISLF.js → chunk-LCXTQE2B.js}

@@ -1,6 +1,6 @@
 import {
   codeToLoinc
-} from "./chunk-7O6VUA2B.js";
+} from "./chunk-MTWOF55H.js";
 import {
   getDefaultUnit,
   unitToUCUM
@@ -248,4 +248,4 @@ export {
   userProfileToFHIR,
   labResultToFHIRBundle
 };
-//# sourceMappingURL=chunk-LPYXISLF.js.map
+//# sourceMappingURL=chunk-LCXTQE2B.js.map

package/dist/{chunk-CBGEU6SG.cjs → chunk-MMO356YH.cjs}

@@ -1500,6 +1500,18 @@ var biomarkerRangeDefinitions = {
       }
     ]
   },
+  // Revisão sistemática de 78 estudos, catorze países, incluindo população
+  // centro-americana: o limite médio ficou em 0,50 para homens e para
+  // mulheres, e é o mesmo para os dois sexos, daí não haver variantes.
+  //
+  // Só `max`. O limite inferior não entra porque a revisão não estabelece
+  // piso, e inventar um transformaria em alteração um valor que a fonte não
+  // classifica.
+  WaistToHeightRatio: {
+    default: { max: 0.5, unit: "" },
+    direction: "lower-better",
+    source: "browning-ashwell-2010"
+  },
   AndroidGynoidRatio: {
     default: { max: 1.2, min: 0.5, optimalMax: 1, optimalMin: 0.6, unit: "" },
     direction: "lower-better",
@@ -1949,4 +1961,4 @@ function applyFallbackReferenceRanges(biomarkers) {
 
 
 exports.biomarkerRangeDefinitions = biomarkerRangeDefinitions; exports.defaultReferenceRanges = defaultReferenceRanges; exports.getReferenceRange = getReferenceRange; exports.getRangeDirection = getRangeDirection; exports.getFallbackReferenceRange = getFallbackReferenceRange; exports.applyFallbackReferenceRanges = applyFallbackReferenceRanges;
-//# sourceMappingURL=chunk-CBGEU6SG.cjs.map
+//# sourceMappingURL=chunk-MMO356YH.cjs.map